WorldWideScience

Sample records for policy institute ipi

  1. Preliminary Report IPI Institute. Summer 1966.

    Science.gov (United States)

    Research for Better Schools, Inc., Philadelphia, PA.

    Individually Prescribed Instruction (IPI), a project based on a carefully sequenced and detailed listing of behaviorally stated objectives, lesson materials geared to instructional objectives, provision for diagnosis of pupil skills and abilities, written prescriptions to guide the pupil's work, and pupil oriented instruction, is outlined first in…

  2. Individually Prescribed Instruction. A Manual for the IPI Institute.

    Science.gov (United States)

    Scanlon, Robert G.

    Offered primarily as a point of departure for educators who intend to apply IPI in American schools, this manual opens with a history of individualization which incorporates a rationale of IPI by Robert Glaser. Section II discusses educational diagnosis, diagnostic instruments and materials; section III is devoted to prescription writing, whilst…

  3. IPI tax relief policy and its impact on automotive and related sectors

    Directory of Open Access Journals (Sweden)

    Luiz Antônio Abrantes

    2017-09-01

    Full Text Available The policy of IPI tax relief in the automotive industry came from the need of answers to the Global Financial Crisis of 2008, which affected Brazil. This way, Brazilian Government set the reduction of the percentages of rates applied to automotive products and related sectors, according to several factors such as engine power, fuel type and production site, in order to restore the sector demand and stimulate the economy. In this context, this work aims to evaluate the implications of IPI tax relief policy, since 2009, on the turnover of joint-stock companies of the automotive and related sectors. The methodology was a multiple regression analysis model with Dynamic Panel data, in order to explain the variations of companies' turnover in the sector, regarding IPI tax relief. The data used were of 84 companies of this sector, for the period from 1998 to 2015, based on the software Economática. The results showed a decrease of IPI tax collection in the periods of relief, both in general and specific scope. In addition, we verified that the adoption of the policy had a negative influence on the turnover of the evaluated companies. Thus, we concluded that the tax policy under analysis did not contribute to an increase of automotive sector companies' turnover.

  4. Institutional analysis for energy policy

    Energy Technology Data Exchange (ETDEWEB)

    Morris, F.A.; Cole, R.J.

    1980-07-01

    This report summarizes principles, techniques, and other information for doing institutional analyses in the area of energy policy. The report was prepared to support DOE's Regional Issues Identification and Assessment (RIIA) program. RIIA identifies environmental, health, safety, socioeconomic, and institutional issues that could accompany hypothetical future scenarios for energy consumption and production on a regional basis. Chapter 1 provides some theoretical grounding in institutional analysis. Chapter 2 provides information on constructing institutional maps of the processes for bringing on line energy technologies and facilities contemplated in RIIA scenarios. Chapter 3 assesses the institutional constraints, opportunities, and impacts that affect whether these technologies and facilities would in fact be developed. Chapters 4 and 5 show how institutional analysis can support use of exercises such as RIIA in planning institutional change and making energy policy choices.

  5. Rationality, institutions and environmental policy

    Energy Technology Data Exchange (ETDEWEB)

    Vatn, Arild [Department of Economics and Resource Management, Norwegian University of Life Sciences, Aas (Norway)

    2005-11-01

    This paper is about how institutions determine choices and the importance of this for environmental policy. The model of individual rational choice from neoclassical economics is compared with the model of socially determined behavior. While in the first case, institutions are either exempted from or understood as mere economizing constraints on behavior, the latter perspective views institutions as basic structures necessary also to enable people to act. The paper develops a way to integrate the individualistic model into the wider perspective of social constructivism by viewing it as a special form of such construction. On the basis of this synthesis three issues with relevance for environmental economics are discussed. First, the role of institutional factors in the process of preference formation is emphasized. Next, the role of institutions for the choice of desired states of the environment is analyzed. Finally, the effect of various policy instruments to motivate people to produce these states is discussed. It is concluded that the core policy issue is to determine which institutional frameworks are most reasonable to apply to which kind of problem. Issues, which from the perspective of neoclassical economics are pure technical, become serious value questions if understood from an institutional perspective.

  6. Environmental Studies in the Boreal Forest Zone: Summer IPY Institute at Central Boreal Forest Reserve, Fedorovskoe, Tver area, Russia (14-28 August, 2007)

    Science.gov (United States)

    Sparrow, E. B.; Kurbatova, Y.; Groisman, P.; Alexeev, V.

    2007-12-01

    The Summer Institute was organized by the International Arctic Research Center (IARC) at the University of Alaska Fairbanks, in collaboration with the A.N. Severtsov Institute for Ecology and Evolution of the Russian Academy of Sciences in Moscow, Russia, and the Central Forest State Nature Biosphere Reserve in Fedorovskoe, Russia. The Institute was arranged as a part of the education/outreach activities of the International Polar Year (IPY) at the University of Alaska and the Northern Eurasia Earth Science Partnership Initiative (NEESPI) and was held in Russia. The Institute provided a unique opportunity for participants to learn about the climate and environment of Northern Eurasia from leading scientists and educators, in a wide spectrum of polar and Earth system science disciplines from meteorology, biology, chemistry, and earth system modeling. Additionally, the Institute attendees observed and participated in the biospheric research activities under the guidance of experienced scientists. During a two-week-interval, the School attendees heard 40 lectures, attended several field trips and participated in three brainstorming Round Table Workshop Sessions devoted to perspectives of the boreal forest zone research and major unresolved problems that it faces. Thirty professors and experts in different areas of climate and biosphere research from Russia, the United States, Germany, Finland, and Japan, shared their expertise in lectures and in round table discussions with the Institute participants. Among the Institute participants there were 31 graduate students/early career scientists from six countries (China, Russia, Estonia, Finland, UK, and the United States) and eight K-12 teachers from Russia. The two groups joined together for several workshop sessions and for the field work components of the Institute. The field work was focused on land-atmosphere interactions and wetland studies in the boreal forest zone. Several field trips in and outside the Forest

  7. The institutional framework of Industrial policies

    OpenAIRE

    Sandrine Labory; Patrizio Bianchi

    2014-01-01

    This paper argues that the institutional framework of industrial policies derives from the analysis of industries as systems. Industries are embedded in specific institutional frameworks with which they co-evolve. However, industrial systems are primarily organised at local level: industries may be global but in the sense that they constitute global networks of local systems. The institutional framework of industrial policy derives from this result: industrial policy acts at different levels,...

  8. Institutional Support : Kenya Institute for Public Policy Research and ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    In 2006 the Government of Kenya passed an Act of Parliament making the Kenya Institute for Public Policy Research and Analysis (KIPPRA) the government's lead socioeconomic research institute. The Act exerts enormous demands on KIPPRA at a time when it is trying to recover from the senior staff turnover suffered in ...

  9. Institutional Constraints, Legislative Activism, and Policy Change

    DEFF Research Database (Denmark)

    Citi, Manuele; Justesen, Mogens Kamp

    of regulatory reform in the EU. The rise in the number of legislative proposal, in turn, is affected by the extent of gridlock between the EU’s legislative bodies. These findings show that the Commission steps up its legislative activity when the institutional opportunity space allows for greater policy change.......This paper studies how institutional constraints affect legislative activism, and how legislative activism affects policy change, analyzing the case of the European Union’s legislative process. Our argument revolves around the key role of the Commission in advancing policy change, and emphasizes...... that the Commission can successfully push for increased policy change by increasing its legislative activity when the institutional opportunity space widens. Using a novel panel dataset covering eight policy sectors from 1984--‐2012, we find that the number of legislative proposals significantly affects the extent...

  10. Aiding IPI. A Manual for Teacher Aides in IPI Mathematics.

    Science.gov (United States)

    Fawcett, Temple

    The objectives of this manual are to provide general information about individualized instruction and the Individually Prescribed Instruction (IPI) mathematics program, to familiarize the user with the materials used in IPI Mathematics, to provide a chance to practice necessary skills, and to give suggestions for making the job of the IPI aide…

  11. International institutions and China's health policy.

    Science.gov (United States)

    Huang, Yanzhong

    2015-02-01

    This article examines the role of international institutional actors in China's health policy process. Particular attention is paid to three major international institutional actors: the World Bank, the World Health Organization, and the Global Fund to Fight AIDS, Tuberculosis and Malaria. Through process tracing and comparative case studies, the article looks at how international institutions contribute to policy change in China and seeks to explain different outcomes in the relationship between international institutions and China's health policies. It finds that despite the opaque and exclusive authoritarian structure in China, international institutions play a significant role in the country's domestic health governance. By investing their resources and capabilities selectively and strategically, international institutions can change the preferences of government policy makers, move latent public health issues to the government's agenda, and affect the timing of government action and the content of policy design. Furthermore, the study suggests that different outcomes in the relationship between China's health policies and global health governance can be explained through the seriousness of the externalities China faces. Copyright © 2015 by Duke University Press.

  12. Institutional Support : Economic Policy Research Centre (EPRC ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    The Economic Policy Research Centre (EPRC) was established in 1993 as an autonomous not-for-profit policy research institute with support from the Government of Uganda, donor agencies and ... Addressing Africa's unmet need for family planning by intensifying sexual and reproductive and adolescent health research.

  13. Institutional Constraints, Legislative Activism and Policy Change

    DEFF Research Database (Denmark)

    Citi, Manuele; Justesen, Mogens Kamp

    2016-01-01

    This article presents a study of how institutional constraints affect legislative activism and how legislative activism in turn affects policy change through an analysis of the European Union's legislative process. The argument revolves around the key role of the European Commission in advancing...... policy change, and emphasises that the Commission can successfully push for increased policy change by increasing its legislative activity when the institutional opportunity space widens. Using a novel panel dataset covering eight policy sectors from the period 1984–2012, the article shows...... that the number of legislative proposals significantly affects the extent of regulatory reform in the EU. The rise in the number of legislative proposals, in turn, is affected by the extent of gridlock between the EU's legislative bodies. These findings show that the Commission steps up its legislative activity...

  14. Scientific Data as the Core Legacy of IPY

    Science.gov (United States)

    Parsons, M. A.

    2008-12-01

    The interdisciplinary breadth of the International Polar Year is unprecedented. The IPY has explicit objectives to link researchers across different fields to address questions and issues lying beyond the scope of individual disciplines and to strengthen international coordination of research and enhance international collaboration and cooperation. The IPY Data Policy and Management Subcommittee have developed a policy to help meet these objectives and an international collaboration of investigators and data managers, the IPY Data and Information Service, are working to make IPY data widely available. I will present an overview of the primary data management considerations for IPY and how diverse organizations are making IPY and related data available. Centralized discovery mechanisms for widely distributed data plus targeted access mechanisms for specific disciplines will be presented. These range from near real time access to satellite remote sensing data and GCM output to fair and appropriate access to traditional knowledge of the Arctic. These mechanisms reflect significant advancement in polar data management, but they belie the major challenges that remain. These challenges include fostering a culture change in science that puts greater value on data publication and open data access as well as developing sustained systems and business models for the long-term preservation of IPY data. This will be crucial to ensuring the legacy of IPY, a major objective of IPY sponsors, ICSU and WMO. New efforts to ensure this legacy include the development of the WMO Information System, the Sustained Arctic Observing Network, and the Global Earth Observing System of Systems; the reform of ICSU's World Data Center System; and the results of the Electronic Geophysical Year.

  15. Sustainable Development Policy Institute Immersion Program on ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Moreover, university students in the public sector education system are not exposed to academic culture, research standards and methodologies that are ... Development Policy Institute (SDPI) to train a core pool of graduates and young professionals to undertake social science research in Pakistan and South Asia.

  16. Agents of Institutional Change in EU Policy

    DEFF Research Database (Denmark)

    de la Porte, Caroline; Natali, David

    2018-01-01

    The contribution addresses – through actor-centred historical institutionalism – why and how social investment (SI) emerged at the European Union (EU) level. SI policies built on the institutional basis of the policy co-ordination processes in employment and social inclusion, which originated...... in the late 1990s and early 2000s. The pre-existent processes represented the necessary but not sufficient condition for the EU SIP to materialise. The decisive factor was the activity of three types of entrepreneurs – intellectual, bureaucratic and political – that enabled the crystallization of the EU......, the Commission’s political priorities changed and the key entrepreneurs that had been active for the materialisation of the SIP were no longer centre stage. The continued presence of former influential entrepreneurs in the EU policy arena, although in different roles, may enable integration of EU SI into new EU...

  17. Introduction: Institutional corruption and the pharmaceutical policy.

    Science.gov (United States)

    Rodwin, Marc A

    2013-01-01

    Today, the goals of pharmaceutical policy and medical practice are often undermined due to institutional corruption - that is, widespread or systemic practices, usually legal, that undermine an institution's objectives or integrity. In this symposium, 16 articles investigate the corruption of pharmaceutical policy, each taking a different look at the sources of corruption, how it occurs, and what is corrupted. We will see that the pharmaceutical industry's own purposes are often undermined. Furthermore, pharmaceutical industry funding of election campaigns and lobbying skews the legislative process that sets pharmaceutical policy. Moreover, certain practices have corrupted medical research, the production of medical knowledge, the practice of medicine, drug safety, the Food and Drug Administration's oversight of the pharmaceutical market, and the trustworthiness of patient advocacy organizations. © 2013 American Society of Law, Medicine & Ethics, Inc.

  18. TTI Phase 2 Institutional Support: Sustainable Development Policy ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    TTI Phase 2 Institutional Support: Sustainable Development Policy Institute. This funding will strengthen the Sustainable Development Policy Institute's (SDPI) role as a credible public policy institution in Pakistan by enhancing its ability to provide high-quality, influential, and policy-relevant research. About the Sustainable ...

  19. Chinese climate policy - Institutions and intent

    International Nuclear Information System (INIS)

    Ramsay, William C.; Lesourne, Jacques

    2011-06-01

    Until the late 1990's, the balance of Chinese energy production and consumption was treated by the rest of the world as a net figure. No one knew what was going on inside the Chinese economy - it was a black box. As far as anyone was concerned, the Chinese would not soon be a major factor in world energy markets. Energy policy-makers realized how totally blind they were in 2004 when Chinese electricity production could not keep up with internal demand and the world experienced a surge in liquids demand as Chinese entrepreneurs fired up generator sets across the economy. No country has confronted the need to collect data and formulate coherent policy for nearly a billion and a half consumers. A number of institutional arrangements have succeeded each other until now, when stronger energy policy and administrative functions of the National Development and Reform Commission (NDRC) are gaining traction. NDRC vice-chairman Zhang Guobao has maintained a steady hand on Chinese energy-policy evolution for several years - overseeing the increasing coherence of Chinese domestic and international energy policy - but the tension with powerful state enterprises and other vested interests still effectively defies efforts to truly centralize Chinese national-level energy policy and program authority. This study identifies the nature of the forces that drive or constrain change within China's energy sector, and explores the Chinese approach to climate change. Contents: 1. The Institutions of Energy Governance in china. 2. China's Foreign Energy Policy. 3. China's position and policy on climate change

  20. Rural electrification policy and institutional linkages

    International Nuclear Information System (INIS)

    Haanyika, Charles Moonga

    2006-01-01

    Some of the problems that have besieged rural electrification in most developing countries include inadequate policies, weak institutional frameworks and limited financing. In the last two decades, governments in developing countries have been making various efforts both at the policy level and in financing to facilitate increased levels of rural electrification. However, the introduction of market-based reforms in the power sector in the last decade has affected the institutional and financing arrangements for rural electrification. The reforms have also affected the rate of electrification and affordability of electricity. There is need therefore to establish the extent to which the reforms have affected access and affordability of electricity in rural areas and to develop appropriate policy and the supporting institutional structures to align rural electrification with reformed power sectors. It is cardinal to establish how privatised and commercialised power companies in a reformed power sector could contribute to rural electrification and the role of governments and government agents in facilitating expanded access to electricity in rural areas

  1. IPI and the Affective Domain.

    Science.gov (United States)

    Rookey, T. Jerome

    Reported is a study of the effectiveness of the Individually Prescribed Instructional (IPI) system. The purpose was to assess the levels of self-initiation, direction, and evaluation for differently treated pupils. Samples were comprised of the pupils and teachers from eight IPI and eight control schools. Fourth- through sixth-grade students were…

  2. Institutional factors, government policies and appropriate technologies.

    Science.gov (United States)

    Watanabe, S

    1980-01-01

    Traditionally the use of inappropriate technologies in the developing countries has been explained by the existence of factor price distortions, e.g. the price of labor being artificially raised by labor legislation, and the price of capital being reduced by subsidies and unrealistic exchange rates. In reality the technological choice is often determined by economic conditions and the local sociocultural/political conditions. The institutional framework of the country may discourage the appropriate technology. The obstacles can be overcome when the following conditions are met: 1) a national consensus about the need for development efforts and importance of policy goals; 2) promising market prospects and/or an effective marketing system; and, 3) sufficient industrial competition in both home and international markets. Institutional problems come from the generation and diffusion of technologies from the supply side which are introduced to people who do not see the need for them. More emphasis on the marketing side ususally results in application of correct technology, especially where governments fund research and development projects and formulate their plans on the basis of a concrete investment or production plan and a clear idea about the target market. Land reforms and agricultural price policies are needed as well as the establishment of an efficient national administrative network.

  3. Chinese Climate Policy - Institutions and Intent

    International Nuclear Information System (INIS)

    Ramsay, William C.; Lesourne, Jacques; Andrews-Speed, Philip; Yishan, Xia; Dezhao, Chen

    2011-06-01

    Until the late 1990's, the balance of Chinese energy production and consumption was treated by the rest of the world as a net figure. No-one knew what was going on inside the Chinese economy - it was a black box. As far as anyone was concerned, the Chinese would not soon be a major factor in world energy markets. Energy policy makers realized how totally blind they were in 2004 when Chinese electricity production could not keep up with internal demand and the world experienced a surge in liquids demand as Chinese entrepreneurs fired up generator sets across the economy. The incremental Chinese demand was a factor in the price surge that year that had been building since the OPEC accord in 1999. It was probably the catalyst for the spike but we didn't have the data to know. Times are certainly changing, but it is still only twilight in that black box. No country has confronted the need to collect data and formulate coherent policy for nearly a billion and a half consumers. State enterprises were set up to manage key energy sector activities, but coordinating among them proved difficult. A number of institutional arrangements have succeeded each other until now, when stronger energy policy and administrative functions of the National Development and Reform Commission (NDRC) are gaining traction. NDRC vice-chairman Zhang Guobao has maintained a steady hand on Chinese energy-policy evolution for several years - overseeing the increasing coherence of Chinese domestic and international energy policy - but the tension with powerful state enterprises and other vested interests still effectively defies efforts to truly centralize and co-ordinate Chinese national-level energy policy and program authority. The first of the three studies looks back into the nature of Chinese institutions and governance for insights into how they function and to identify some of their limits, so as to pinpoint the nature of the forces that drive or constrain change within China's energy sector

  4. Institutional Support to Policy Research Organizations in India ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Institution. Center for Study of Science, Technology and Policy. Pays d' institution. India. Site internet. http://www.cstep.in ... Institution. (Chief, Administrative Services) for and on behalf of Centre for Policy Research Registered Society. Pays d' institution. India. Site internet. http://www.cprindia.org ...

  5. Institutional Support : Institute for Policy Analysis and Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Au départ la division tanzanienne du Réseau d'études sur la politique technologique en Afrique (African Technology Policy Studies Network), et ce, depuis 1984, ATPS-Tanzania est devenu... Voir davantageSoutien institutionnel à African Technology Policy Studies - Tanzania (ATPS-Tanzania). Nous finançons des ...

  6. TTI Phase 2 Institutional Support: Institute of Policy Studies of Sri ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    IPS is an autonomous institution that promotes policy-oriented economic research and strengthens the capacity for policy analysis in Sri Lanka. The institute's research agenda ... -make significant new inroads into research and policy networks, with new collaborations and global visibility -improve its research rigour, with ...

  7. Policy, Institutional and Programme Readiness for Solar Energy ...

    African Journals Online (AJOL)

    In response, policies and institutions have emerged to promote solar energy. This study investigates policy, institutional and programme readiness to embrace solar energy uptake in the country. The study reveals that South Africa has put in place numerous initiatives, like the Renewable Energy Independent Power ...

  8. [Evaluation of the enhanced International Prognostic Index (NCCN-IPI) for cases with diffuse large B-cell lymphoma].

    Science.gov (United States)

    Yamada, Akiko; Tamura, Hideto; Asayama, Toshio; Moriya, Keiichi; Okuyama, Namiko; Kondo-Onodera, Asaka; Hamada, Yasuko; Ishibashi, Mariko; Yokose, Norio; Tanosaki, Sakae; Inokuchi, Koiti

    2015-07-01

    The NCCN-International Prognostic Index (IPI) is reported to be more powerful than the former IPI for predicting survival in the rituximab era. To evaluate the NCCN-IPI in our institutions, we analyzed 188 patients with diffuse large B-cell lymphoma treated with rituximab plus CHOP or THP-COP chemotherapy. The 5-year overall survival rates of patients with low, low-intermediate, high-intermediate, and high risk were 90%, 76%, 64%, and 34%, respectively. Although there was no difference in overall survival between patients 61-75 and those >75 years of age, the NCCN-IPI is useful for classifying prognostically relevant subgroups of Japanese patients.

  9. Institutional Support : Institute of Policy Analysis and Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    This grant from IDRC's Think Tank Initiative (TTI) will help IPAR address its sustainability issues by offering competitive remuneration packages to reduce staff turnover, recruiting additional staff, training existing staff, improving organizational systems and infrastructure, expanding its policy advocacy work, enhancing the ...

  10. Institutional Support : Institute of Policy Analysis and Research (IPAR)

    International Development Research Centre (IDRC) Digital Library (Canada)

    This grant from IDRC's Think Tank Initiative (TTI) will help IPAR address its sustainability issues by offering competitive remuneration packages to reduce staff turnover, recruiting additional staff, training existing staff, improving organizational systems and infrastructure, expanding its policy advocacy work, enhancing the ...

  11. TTI Phase 2 Institutional Support: Social Policy and Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    This funding will enhance the Social Policy and Development Centre's (SPDC) role as a credible public policy institution in Pakistan by strengthening its ability to provide high-quality, influential, and policy-relevant research ... -strengthen its presence and visibility at the national level, particularly in the capital city, Islamabad

  12. Issues for Agricultural Extension Policy: Structures and Institutional ...

    African Journals Online (AJOL)

    This paper examined issues pertaining to structures and institutional arrangement for agricultural extension policy. It highlighted the broad objectives of the new policy thrust in agriculture in Nigeria, and identified sub-policies that were expected to facilitate growth of the agricultural sector of the economy. Agricultural ...

  13. TTI Phase 2 Institutional Support: Economic Policy Research Centre ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Sound research, policy influence. TTI is a multi-funder program dedicated to strengthening independent policy research institutions, or think tanks, in developing countries. The program aims to enhance their ability to provide sound research that informs and influences policy. This second TTI phase (2014?2019) will fund 43 ...

  14. TTI Phase 2 Institutional Support: Centre for Policy Research | IDRC ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    CPR is an independent, non-partisan research institute focused on improving policy-making and management, and promoting national development in India. CPR's research covers ... For CPR, this project will help enhance its research quality, organizational performance, and policy engagement. Policy influence in India

  15. TTI Phase 2 Institutional Support: Centre for Policy Research | CRDI ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    CPR is an independent, non-partisan research institute focused on improving policy-making and management, and promoting national development in India. CPR's research covers ... For CPR, this project will help enhance its research quality, organizational performance, and policy engagement. Policy influence in India

  16. Do Schools Need IPI? No!

    Science.gov (United States)

    Tillman, Rodney

    1972-01-01

    Discusses factors the author considers drawbacks of IPI: 1) The strong emphasis on sequence; 2) The validity placed on diagnostic tests; 3) The determination of 85 percent correct responses as a major criterion for determining success; 4) Discussion and interpersonal skills are not developed. (Author/AF)

  17. TTI Phase 2 Institutional Support: Institute of Policy Studies of Sri ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    IPS is an autonomous institution that promotes policy-oriented economic research and strengthens the capacity for policy analysis in Sri Lanka. The institute's research agenda includes poverty and social welfare, environmental economics, agricultural economics, and human resources development. IPS receives its funding ...

  18. Building on IPY Data, Collaborations and Infrastructure to Understand the Changing Poles (Invited)

    Science.gov (United States)

    Bell, R. E.; Krupnik, I.; Hik, D.; Alverson, K. D.; Drinkwater, M. R.

    2010-12-01

    In contrast to previous IPY programs that were driven by a central organizing group, the 2007-9 IPY emerged from more than 1000 ideas provided by the global science community. This global IPY planning process produced six major themes that framed the IPY programs. Three themes focused on change at the poles, one focused on probing the frontiers of the polar science, one targeted on using the polar regions as vantage points to look beyond into space and a sixth theme targeted integrated studies of polar cultural, historical and social processes. The results of the IPY 2007-9 are just beginning to emerge. Benchmark data sets were acquired such as coordinated imaging of the poles from space, systematic ocean measurements and a census of marine life. IPY programs have documented how ongoing polar change from permafrost to ecosystems varies regionally depending on local conditions. Analysis of past change in ecosystems, sediment cores and numeric models indicate that during periods with elevated temperatures and atmospheric CO2, the West Antarctic ice sheet can collapse repeatedly. Studies of the polar oceans have confirmed a strong connection between the mid-latitudes and polar processes. The efforts to explore the poles have revealed explosive volcanism beneath the Arctic Ocean, strong genetic similarities between microbes at the two poles and dynamic processes at the base of the East Antarctic ice sheet. IPY programs looking beyond the poles imaged new galaxies and identified new linkages between solar output and weather. The early insights from IPY 2007-9 are remarkable. Building on these will be a challenge for the science community and science agencies over the next decade. The IPY data must be archived and made available to the broad science community to ensure it is preserved as a vital benchmark. The collaborations between scientists, agencies, Arctic residents and institutions initiated by the IPY structure must be fostered and continued. Successful scientific

  19. Trade policies, institutions and the natural resource curse

    NARCIS (Netherlands)

    Arezki, R.; van der Ploeg, F.

    2010-01-01

    We offer new cross-country evidence on the natural resource curse. We investigate the impact of the interaction of natural resource abundance and policies on growth. We find that the resource curse is less severe in countries with less restrictive trade policies and good institutions. However, we

  20. Institutional Support to Policy Research Organizations in India ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    IDRC's Think Tank Initiative is a multi-donor program dedicated to strengthening independent policy research institutions, or "think tanks," in developing countries, thereby enabling them to produce sound research that both informs and influences policy. The Initiative selected the first cohort of 24 grantees in East and West ...

  1. On the influence of institutional design on monetary policy making

    NARCIS (Netherlands)

    Raes, L.B.D.

    2014-01-01

    This thesis consists of a collection of essays on monetary policy making. These essays focus on institutional aspects which impact monetary policy making. Two chapters focus on analyzing voting records of central banks. A method is proposed to use the observed votes to infer the preferences of

  2. Institutional Support to South Asian Policy Research Organizations ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    There are very few policy research organizations in South Asia outside India. Those that exist are fragile due to little demand for policy research, limited if no funding from local sources, and an often insecure political climate. This grant will strengthen the ability of the seven selected research institutions in Bangladesh, Nepal ...

  3. Institutional Support to South Asian Policy Research Organizations ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    IDRC's Think Tank Initiative is a multi-donor program dedicated to strengthening independent policy research institutions (think tanks) in developing countries, thereby enabling them to produce sound research that both informs and influences policy. The Initiative selected the first cohort of 24 grantees in East and West ...

  4. Aging in France: Population Trends, Policy Issues, and Research Institutions

    Science.gov (United States)

    Beland, Daniel; Durandal, Jean-Philippe Viriot

    2013-01-01

    Like in other advanced industrial countries, in France, demographic aging has become a widely debated research and policy topic. This article offers a brief overview of major aging-related trends in France. The article describes France's demographics of aging, explores key policy matters, maps the institutional field of French social gerontology…

  5. Market, policy and institutional failures in agriculture and their ...

    African Journals Online (AJOL)

    Unsustainable and inefficient resource use in developing countries has often been attributed to markets and government decisions or policies not fully reflecting environmental values. This paper discusses various examples of market, policy and institutional failures in agriculture and their environmental impacts. The paper ...

  6. Institutional and Policy Support for Tourism Social Entrepreneurship

    DEFF Research Database (Denmark)

    Dredge, Dianne

    2017-01-01

    and operation of social enterprises as part of an inclusive and sustainable tourism system, and they can assist in the creation of institutional conditions that encourage, legitimize and synergize social entrepreneurship. The chapter offers concrete considerations for policy makers in terms of making...... the characteristics of supportive institutional and policy environments for tourism social entrepreneurship. It argues that governments can contribute in two broad ways to creating the conditions for tourism social entrepreneurship to flourish: they can develop policies that support and encourage the development...

  7. RATIONAL CHOICE INSTITUTIONALISM AND THE EUROPEAN NEIGHBOURHOOD POLICY

    OpenAIRE

    Andrei Cristian Balasan; Andreea Maha

    2013-01-01

    The aim of this paper is to highlight the main aspects regarding the rational choice theory in neo-institutionalism, and the role the EU Neighbourhood Policy has nowadays. The protagonist of the rational choice theory in the new institutionalism remains homo-economicus. The theory of rational choice institutionalism challenges the perfect rationality of the individual, rather than the principle of rational choice itself. ENP is a framework for consolidating the Union's relations with neighbou...

  8. Policy research institutions and the health SDGs: Building ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Institution. Sustainable Development Policy Institute. Pays d' institution. Pakistan. Site internet. http://www.sdpi.org ... du secteur de la sécurité en Asie du Sud. En Asie du Sud, le discours sur la sécurité a généralement eu cours dans les milieux gouvernementaux sans que les voix de la société civile s'y fassent entendre.

  9. ROLE OF DEPOSIT POLICY FOR UKRAINIAN BANKING INSTITUTIONS

    Directory of Open Access Journals (Sweden)

    Nadezhda Bova

    2015-11-01

    Full Text Available The purpose of the paper is to define and demonstrate the role of deposit policy for banking institutions, summarize and highlight the problems and its solutions in deposit policy of Ukraine that provides economic downturn and recovery. Appropriate selection and implementation of the deposit policy objectives, its operational structure and tools determines the degree of development of financial inclusion, which generate developed financial market, ensures public confidence to the deposit services, and increases the level of savings that positively affects the banking system financial stability and economy in the country in whole. It is because of availability and security deposit services, commercial banks of Ukraine have the opportunity to increase its resource base due to savings of the population. Methodology. The paper is based on a synthesis of data to explore the bank deposit policy situation. The paper considers the scientific and theoretical approaches for the developing the deposit policy management. It contains the analysis of the dynamics and current situation and conditions of the resource potential of banking institutions in Ukraine. Results of the article shows direct dependency between savings, consumption and deposit policy, therefore every banking institution includes the mechanism of banking management of the development and implementation of deposit policy. Also, this management defines the deposit policy directions according to the conditions of bank resources mobilization and its applying in active operations. The obtained results confirm that the term “deposit policy” is too complex, but it is investigated in interaction with banking activity. It is explained how deposit policy influences banking system and has impact on economic growth in general. Practical implications. The research creates methodological approaches to the measurement of effectiveness of deposit policy. Also, it studies the existing ones. It provides

  10. SOCIAL POLICY AS FACTOR OF STATE INSTITUTIONAL STATUS

    Directory of Open Access Journals (Sweden)

    Larysa Zhukova

    2016-11-01

    Full Text Available The purpose of the article is the research of theoretical and methodological aspects of social policy as the factor of institutional state statuses. Methodology. The researching in institutional providing of state social policy which may be considered as the base for performance of correspond reforms which are directed to the life level increasing, is enough popular task in scientific, theoretical and practical aspects. The scientific search of social policy as the factor of institutional status of state is carried out at the base of classical, neoclassical and institutional methodology. At the base of classical methodology it were defined the general approaches with help of dialectical analysis tools and synthesis of social relations array as historical action. With the help of system, structurally-functional analysis of social policy tasks, it’s opened its internal nature and ways of institutional providing. Institutional and neoclassical approaches allowed the specials analysing tools in modelling of dynamics and institute of social policy institute results in the conditions of market transformations. Also in the research process it were used the economic articles about the question of analysis in state social policy and given the statistic data about the analytical report to the annual President’s of Ukraine message to Verkhovna Rada of Ukraine „About internal and external condition of Ukraine in year 2015”. Research results showed what in the conditions of socially-economic and political instability, the social sphere Ukraine became the hostage of common crisis in economic, catastrophic decreasing of life level, increasing of social confrontation and rough system mistakes in the process of social institution formation. All of this neutralizes the methods efficiency about improvement of socially-economic condition of population and prevents to the implementation of necessary reforms. Practical value lays in the clear definition of

  11. RATIONAL CHOICE INSTITUTIONALISM AND THE EUROPEAN NEIGHBOURHOOD POLICY

    Directory of Open Access Journals (Sweden)

    Andreea Maha

    2013-09-01

    Full Text Available The aim of this paper is to highlight the main aspects regarding the rational choice theory in neo-institutionalism, and the role the EU Neighbourhood Policy has nowadays. The protagonist of the rational choice theory in the new institutionalism remains homo-economicus. The theory of rational choice institutionalism challenges the perfect rationality of the individual, rather than the principle of rational choice itself. ENP is a framework for consolidating the Union's relations with neighbouring countries and aims therefore intensifying cooperation with them in order to establish a zone of prosperity, good neighbourliness, stability and security.

  12. Teaching in IPI. Volume I. A Program of Teacher Preparation.

    Science.gov (United States)

    Moshy, Claire A.

    'Teaching in IPI' is an introductory program designed to equip the teacher with the basic skills required to plan and conduct IPI in the classroom. It comprises five volumes, of which this--divided into two sections: An Overview of Individualized Instruction and IPI, and Behavioral Objectives and the IPI Mathematics Continuum--is the first.…

  13. Institutional Statements of Commitment and Widening Participation Policy in Australia

    Science.gov (United States)

    Chapman, Amy; Mangion, Antoine; Buchanan, Rachel

    2015-01-01

    This article describes ways in which the equity agenda, as outlined in the Bradley Review of Higher Education (Bradley et al., 2008), is translated into action in one Australian university. Drawing on the conceptual work of Ahmed (2012) to elaborate institutional life, we investigate the effects of the widening participation policy. Ahmed (2012)…

  14. Institutional Diversity in Ontario's University Sector: A Policy Debate Analysis

    Science.gov (United States)

    Piché, Pierre G.; Jones, Glen A.

    2016-01-01

    In order to meet the demands in a cost-effective manner of an emerging knowledge society that is global in scope, structural higher education policy changes have been introduced in many countries with a focus on systemic and programmatic diversity. There has been an ongoing debate about institutional diversity in Ontario higher education,…

  15. No Policy for Public Private Partnership? PPP, Collaboration and Institutions

    DEFF Research Database (Denmark)

    Tolstrup Christensen, Lene; Greve, Carsten

    infrastructure projects and public service provision contracts in the transport sector within roads and busses, bridges and tunnels, rail, airports and aviation and harbors. The projects will be categorized in relation to organizational and financial models and it leads to a. discussion of types of policy...... choices across the sector and the reasons behind whether or not PPP was chosen. The final part of the paper presents an institutional historical account of the Danish case, and focuses on the more general question of how PPP policy planning evolves. There is no direct step from privatization...... policy already, where the PPP policy option did not present itself as the next obvious step, and alternative options were available, the government approach towards PPP is likely to be more reluctant....

  16. NORPERM, the Norwegian Permafrost Database - a TSP NORWAY IPY legacy

    Science.gov (United States)

    Juliussen, H.; Christiansen, H. H.; Strand, G. S.; Iversen, S.; Midttømme, K.; Rønning, J. S.

    2010-10-01

    NORPERM, the Norwegian Permafrost Database, was developed at the Geological Survey of Norway during the International Polar Year (IPY) 2007-2009 as the main data legacy of the IPY research project Permafrost Observatory Project: A Contribution to the Thermal State of Permafrost in Norway and Svalbard (TSP NORWAY). Its structural and technical design is described in this paper along with the ground temperature data infrastructure in Norway and Svalbard, focussing on the TSP NORWAY permafrost observatory installations in the North Scandinavian Permafrost Observatory and Nordenskiöld Land Permafrost Observatory, being the primary data providers of NORPERM. Further developments of the database, possibly towards a regional database for the Nordic area, are also discussed. The purpose of NORPERM is to store ground temperature data safely and in a standard format for use in future research. The IPY data policy of open, free, full and timely release of IPY data is followed, and the borehole metadata description follows the Global Terrestrial Network for Permafrost (GTN-P) standard. NORPERM is purely a temperature database, and the data is stored in a relation database management system and made publically available online through a map-based graphical user interface. The datasets include temperature time series from various depths in boreholes and from the air, snow cover, ground-surface or upper ground layer recorded by miniature temperature data-loggers, and temperature profiles with depth in boreholes obtained by occasional manual logging. All the temperature data from the TSP NORWAY research project is included in the database, totalling 32 temperature time series from boreholes, 98 time series of micrometeorological temperature conditions, and 6 temperature depth profiles obtained by manual logging in boreholes. The database content will gradually increase as data from previous and future projects are added. Links to near real-time permafrost temperatures, obtained

  17. IPI-145 shows promise in CLL patients.

    Science.gov (United States)

    2014-02-01

    Results from a phase I study of Infinity Pharmaceuticals' IPI-145, which inhibits both δ and γ isoforms of phosphoinositide3-kinase, suggest the drug is safe and effective in patients with advanced chronic lymphocytic leukemia.

  18. Policy and institutional dimensions of the water-energy nexus

    International Nuclear Information System (INIS)

    Scott, Christopher A.; Pierce, Suzanne A.; Pasqualetti, Martin J.; Jones, Alice L.; Montz, Burrell E.; Hoover, Joseph H.

    2011-01-01

    Energy and water are interlinked. The development, use, and waste generated by demand for both resources drive global change. Managing them in tandem offers potential for global-change adaptation but presents institutional challenges. This paper advances understanding of the water-energy nexus by demonstrating how these resources are coupled at multiple scales, and by uncovering institutional opportunities and impediments to joint decision-making. Three water-energy nexus cases in the United States are examined: (1) water and energy development in the water-scarce Southwest; (2) conflicts between coal development, environmental quality, and social impacts in the East; and (3) tensions between environmental quality and economic development of shale natural gas in the Northeast and Central U.S. These cases are related to Eastern, Central, and Western regional stakeholder priorities collected in a national effort to assess energy-water scenarios. We find that localized challenges are diminished when considered from broader perspectives, while regionally important challenges are not prioritized locally. The transportability of electricity, and to some extent raw coal and gas, makes energy more suitable than water to regionalized global-change adaptation, because many of the impacts to water availability and quality remain localized. We conclude by highlighting the need for improved coordination between water and energy policy. - Highlights: →Water-energy nexus construct considers institutions not just resource inputs. → Energy policy offers more scope for global-change adaptation than does water policy. → U.S. scenarios highlight water impacts and policy choices of energy development. → Water-energy policy tradeoffs may be mitigated across scales of resource use.

  19. Institutional and Policy Assessment of Renewable Energy Sector in Afghanistan

    Directory of Open Access Journals (Sweden)

    Ahmad Murtaza Ershad

    2017-01-01

    Full Text Available Renewable energy resources could play a vital role in the sustainable economic, social, and environmental development of Afghanistan. Heavy reliance of rural households on firewood, rising costs of fossil fuels, outdoor and indoor air pollution, and climate change are some of the challenges that can be addressed by diversifying our power production fuel inputs and adopting renewable energy technologies. In order to deploy and scale up renewable energy technologies and improve access to sustainable energy, clear policies and targets and dedicated institutions are crucial. Fortunately, Afghan government with the support of international community is setting ambitious targets for the renewable energy sector and is encouraging national and international investors to take part in the generation, transmission, and distribution of renewable energy especially electricity through Power Purchase Agreements or very cheap land leases. Thus, the objectives of this report are (I to review the existing institutions in the field of renewable energy, (II to review renewable energy policies and targets in Afghanistan, and (III to identify institutional and policy gaps and recommend solutions.

  20. Internationalisation policies and international practises in higher education institutions. A case study of five Norwegian higher education institutions

    OpenAIRE

    Frølich, Nicoline

    2005-01-01

    This report examines internationalisation policies and international practises at higher education institutions. It investigates how the external environment of these institutions influences internationalisation policies and international practises. It also analyses how academic values in higher education impact internationalisation policies and international practises.

  1. Creating an institutional conflict-of-interest policy at Johns Hopkins: progress and lessons learned.

    Science.gov (United States)

    Miller, Edward D

    2007-03-01

    Unlike policies that address biomedical conflict of interest for individuals, conflict-of-interest policies for academic medical institutions are rare and lack consensus principles. Johns Hopkins Medicine is currently developing an institutional conflict-of-interest policy that emphasizes case-by-case review and disclosure of conflicts to research subjects and the public. Implementation of the policy will focus on transparency, consistent enforcement throughout the institution, thorough employee education about the policy, and ongoing policy review.

  2. Specific Subject Self Concept in IPI and Non-IPI Students.

    Science.gov (United States)

    Humphrey, Jan

    A questionnaire was given to seventh graders in Individually Prescribed Instruction (IPI) and non-IPI classrooms. It contained items concerning the student's self concept of ability in four subjects: mathematics, English, social studies, and science; and it contained items to determine which method of presentation the student preferred. In the…

  3. Self Concept of Ability in IPI and Non-IPI Students.

    Science.gov (United States)

    Humphrey, Jan

    Self concept of ability as a learner has been shown to be a significant factor in pupil achievement. The Individually Prescribed Instruction (IPI) system was expected to enhance pupils' self concepts of ability. A questionnaire was given to sixth, seventh, and eighth grade students from several schools, one of which used the IPI system. Analysis…

  4. Institutional and legislative issues of emergency management policy in Russia.

    Science.gov (United States)

    Porfiriev, B

    2001-12-14

    The emergency management policy as an organic component of the national development policy in contemporary Russia exists only for a slight more than a decade. However, its basic trends and directions could be revealed. In the legislative area covering technological accidents involving hazardous materials these include increasing differentiation of acts in terms of issue coverage, gradual integration of legislation via enforcement of the so-called systemic (umbrella) acts and increasing incorporation of specific acts, and keeping dominance of federal emergency acts. In addition, emergency legislation and policy programs on communities' protection against major hazards drift from alleviation-oriented towards more mitigation-focused. Meanwhile, the bulk of the existing acts are still specific laws and regulations, which consider most emergency response. In institutional realms the key direction of emergency policy development involved organization and progress of the Unified State System for Emergency Prevention and Elimination of the Russian Federation (USEPE) with EMERCOM as a key coordinator and actor in handling technological hazards and accidents. The detailed analysis of USEPE organizational pattern and operation modes including institutional structure, key functions, means and forces and operation routines is provided. It is argued that the system's logic and flexible organizational framework only to some extent contribute to effective mitigation of the major emergencies and/or disasters. In no less extent it depends on the existing socioeconomic conditions, which have been for a long time unfavorable in Russia and thus seriously constrain the USEPE effectiveness. This provides for ambiguous integral evaluation of the emergency management policy in the 1990s and early 2000s.

  5. Development of Policies, Institutions and Procedures for Water Reuse

    Science.gov (United States)

    Demouche, L.; Pfiefer, J.; Hanson, A.; Skaggs, R.

    2009-12-01

    In the arid, water scarce region of New Mexico and West Texas there is growing interest in the potential for water reuse to extend existing supplies and mitigate drought shortage impacts. There are no new sources of water in New Mexico, except reclaimed water. Communities and individuals are uncertain about and have many unanswered questions about polices, institutions involved (agencies), legal and regulatory requirements, and procedures governing water reuse. Issues to be addressed by this project include: the legal ability to reuse water, ownership of water rights, downstream or third party impacts, regulatory and procedural requirements, water quality concerns, state and local agency involvement, and cost effectiveness of water reuse compared to alternative sources. Presently, there is very little implementation or directives in New Mexico policy that addresses reuse, reclamation, or recycled water. The only regulations pertaining to reuse is New Mexico Environmental Department currently allows the use of reclaimed domestic wastewater for irrigation of golf courses and green spaces, which is listed in the Policy for the Above Ground Use of Reclaimed Domestic Wastewater (NMED, 2003). This document identifies the various reclaimed quality classifications that are required for specific applications and the permits required for application. This document does not identify or address policy applications on the distribution, ownership, or trading of reclaimed water. Even though reclaimed water reuse projects are currently being implemented in many cities in the U.S., mainly for commercial and municipal irrigation (golf courses and green space), its potential has not yet been exploited. A policy analysis matrix (PAM) is being designed to identify and examine the policy framework and consequences of non-policy implementation for decision makers and interest groups and assist them in understanding the consequences of policy actions and project outcomes if no laws or

  6. Phytophthora infestans Effectors IPI-O1 and IPI-O4 Each Contribute to Pathogen Virulence.

    Science.gov (United States)

    Chen, Yu; Halterman, Dennis A

    2017-05-01

    Potato late blight, caused by the oomycete pathogen Phytophthora infestans, is one of the most destructive plant diseases. Despite decades of intensive breeding efforts, it remains a threat to potato production worldwide, because newly evolved pathogen strains have overcome major resistance genes quickly. The RB protein, from the diploid wild potato species Solanum bulbocastanum, confers partial resistance to most P. infestans strains through its recognition of members of the corresponding pathogen effector protein family IPI-O. IPI-O comprises a multigene family and while some variants are recognized by RB to elicit host resistance (e.g., IPI-O1 and IPI-O2), others are able to elude detection (e.g., IPI-O4). IPI-O1 is almost ubiquitous in global P. infestans strains while IPI-O4 is more rare. No direct experimental evidence has been shown to demonstrate the effect of IPI-O on pathogen virulence in the P. infestans-potato pathosystem. Here, our work has demonstrated that in planta expression of both IPI-O1 and IPI-O4 increases P. infestans aggressiveness resulting in enlarged lesions in potato leaflets. We have previously shown that IPI-O4 has gained the ability to suppress the hypersensitive response induced by IPI-O1 in the presence of RB. In this study, our work has shown that this gain-of-function of IPI-O4 does not compromise its virulence effect, as IPI-O4 overexpression results in larger lesions than IPI-O1. We have also found that higher expression of IPI-O effectors correlates with enlarged lesions, indicating that IPI-O can contribute to virulence quantitatively. In summary, this study has provided accurate and valuable information on IPI-O's virulence effect on the potato host.

  7. The institutional economics of market-based climate policy

    International Nuclear Information System (INIS)

    Woerdman, E.

    2005-01-01

    The objective of this book is to analyze the institutional barriers to implementing market-based climate policy, as well as to provide some opportunities to overcome them. The approach is that of institutional economics, with special emphasis on political transaction costs and path dependence. Instead of rejecting the neoclassical approach, this book uses it where fruitful and shows when and why it is necessary to employ a new or neo-institutionalist approach. The result is that equity is considered next to efficiency, that the evolution and possible lock-in of both formal and informal climate institutions are studied, and that attention is paid to the politics and law of economic instruments for climate policy, including some new empirical analyses. The research topics of this book include the set-up costs of a permit trading system, the risk that credit trading becomes locked-in, the potential legal problem of grandfathering in terms of actional subsidies under WTO law or state aid under EC law, and the changing attitudes of various European officials towards restricting the use of the Kyoto Mechanisms

  8. FINANCIAL DEVELOPMENT, INSTITUTIONS AND ECONOMIC POLICY – PANEL DATA EVIDENCE

    Directory of Open Access Journals (Sweden)

    Filippidis Ioannis

    2013-07-01

    Full Text Available In recent years significant researches have been done to identify what are the determinants of financial development. With regard to this outline, the main objective is to investigate the effect of economic, political and social dimension of institutional quality, as well as the effect of political and macroeconomic factors on financial development. More specifically, the present work aims to contribute to the relevant literature in the following ways: i in the econometric front, we employ dynamic panel techniques, that allow for heterogeneity among variables, avoiding the known problems of traditional techniques. More specifically, we employ the “system GMM” estimator developed by Arellano and Bover (1995, and Blundell and Bond (1998, controlling for endogeneity among variables; ii we disentangle into economic, political and social institutional quality in order to quantify the effect of institutions on financial development and check the robustness of our results; iii in the same logic, we decompose our measure of financial openness into equity- and loan-related foreign assets and liabilities in order to assess whether the hoarding of risky vs. riskless assets or the accumulation of equity vs. debt liabilities affect the development of domestic financial institutions; and iv to control for a potential bias among variables, we include a large set of information, which covers all the spectrum of possible effects on finance, giving emphasis on political factors and government policies. Our main finding from the regression analyses is a robust empirical relationship from institutions to financial development, a result consistent with most empirical studies. Also, we find a stronger effect from economic institutions to banking sector development and from political institutions to stock market development. Regarding the trade and finance link, we find that openness has a much stronger association with bank-based finance than with stock market

  9. A Comparative Analysis of Education Policy and Practice: The Case of Institutions in Mumbai and Delhi

    Science.gov (United States)

    Iyengar, Radhika; Surianarain, Sharmi

    2010-01-01

    There exist many actors within the realm of education policy planning and implementation, namely: the policy makers; the national, local and regional institutions engaged in the dissemination and interpretation of these policies; and the educational institutions that implement these policies at the ground level (schools). While schools are largely…

  10. The IPY Education, Outreach and Communication Assessment: How IPY is shaping the future of science outreach

    Science.gov (United States)

    Provencher, J. F.; Baeseman, J. L.; Carlson, D. J.; Timm, K.

    2011-12-01

    The International Polar Year 2007-2008 (IPY) saw unprecedented polar collaboration between scientists, educators and communities, and prioritized science communication alongside a diverse science program. This global effort represents one of the largest investments in polar science outreach to date with IPY outreach occurring in more than 70 countries and involving millions of people, representing a microcosm of science outreach knowledge. In order to understand and learn from the many IPY education, outreach and communication (EOC) projects an ICSU sponsored IPY EOC assessment, managed by the Association of Polar Early Career Scientists (APECS), conducted a global inventory and assessment of IPY EOC programs at the end of the IPY. As a result the project has now gathered information on more than 530 outreach events including endorsed outreach programmes, science partnered outreach projects and simply IPY inspired science outreach events. By talking to communicators and scientists around the world many lessons can be learned on how to engage and actively involve the public, students and early career scientists in polar research in a meaningful way. Through the integration of science outreach from budget to results, dedication of outreach personnel and an inclusive approach to all aspects of science outreach, IPY has demonstrated that the public wants to be engaged in polar issues, and how science can incorporate both good science and effective outreach. This type of public engagement is not only critical for science literacy, it is this level of involvement in science that helps to keep science in the forefront of people's minds, and thus high on the agenda of governments and organizations funding research. At the conclusion of this latest IPY, polar science outreach programs not only supported science that expanded our knowledge of the Polar Regions, it integrated essential, and called for, science education, outreach and communication to a global community.

  11. The IPY 2007-2008 data legacy - creating open data from IPY publications

    Science.gov (United States)

    Driemel, A.; Grobe, H.; Diepenbroek, M.; Grüttemeier, H.; Schumacher, S.; Sieger, R.

    2015-09-01

    The International Polar Year (IPY) 2007-2008 was a synchronized effort to simultaneously collect data from polar regions. Being the fourth in a series of IPYs, the demand for interdisciplinarity and new data products was high. However, despite all the research done on land, people, ocean, ice and atmosphere and the large amount of data collected, no central archive or portal was created for IPY data. In order to improve the availability and visibility of IPY data, a concerted effort between PANGAEA - Data Publisher for Earth and Environmental Science, the International Council for Science (ICSU) World Data System (WDS), and the International Council for Scientific and Technical Information (ICSTI) was undertaken to extract data resulting from IPY publications for long-term preservation. Overall, 1380 IPY-related references were collected. Of these, only 450 contained accessible data. All data were extracted, quality checked, annotated with metadata and uploaded to PANGAEA. The 450 articles dealt with a multitude of IPY topics - plankton biomass, water chemistry, ice thickness, whale sightings, Inuit health, alien species introductions by travellers or tundra biomass change, to mention just a few. Both the Arctic and the Antarctic were investigated in the articles, and all realms (land, people, ocean, ice and atmosphere) and a wide range of countries were covered. The data compilation can now be found with the identifier http://dx.doi.org/10.1594/PANGAEA.150150, and individual parts can be searched using the PANGAEA search engine (http://www.pangaea.de) and adding "+project:ipy". With this effort, we hope to improve the visibility, accessibility and long-term storage of IPY data for future research and new data products.

  12. IPI Science: A Teaching Revolution in the Making, Reprint 51.

    Science.gov (United States)

    Klopfer, Leopold E.; Weber, Victor L., Jr.

    This is a report of the science program under development by the Individually Prescribed Instruction (IPI) project. IPI is developing several elementary curricula (e.g. reading, mathematics) as well as science, and all are characterized by six IPI individualization goals: (a) every student makes regular progress towards mastery of instructional…

  13. Electricity pricing policy: A neo-institutional, developmental and cross-national policy design map

    Science.gov (United States)

    Koundinya, Sridarshan Umesh

    This dissertation explores the role of ideas and ideology in the mental policy design maps of regulators in the US and in India. The research approach is to describe the regulatory design process in the history of the US electric industry from a neo-institutional and developmental perspective. And then to use the insights of such a study to suggest policy options to a sample of Indian experts. A regulatory process model explores the interactions among normative values, regulatory instruments and historical phases in policy design. A spectrum of seven regulatory instruments--subsidized rates, average cost pricing, marginal cost pricing, time-of-use pricing, ramsey pricing, incentive regulation and spot pricing is examined. A neo-institutional perspective characterizes the process of institutionalizing these regulatory instruments as a design process that infuses them with values beyond mere technical requirements. The process model includes normative values such as efficiency, fairness, free choice and political feasibility. These values arise from an analytical classification of various market metaphors debated in the history of economic thought. The theory of development and co-evolution applied to the history of electricity regulation yields a typology of evolutionary phases in the US. The typology describes hierarchically emergent relationships between supply and demand and among the normative values. The theory hypothesizes technologically contingent relationships between pricing policies and normative values in the historical phases of dependence (or rural), independence (or urban) and interdependence (or informational). The contents of this model are represented as related elements in a policy design map that simplifies the process of designing regulatory instruments in the US. This neo-institutional, developmental policy design map was used to design a survey instrument. The survey was conducted among electricity experts in India to test the hypothesized

  14. Loose Coupling and Inhabited Institutions: Inclusion Policy and Teacher Strategies

    Directory of Open Access Journals (Sweden)

    Christina Deroche

    2013-07-01

    Full Text Available This case study uses interviews and participant observation to study how teachers negotiate inclusion policy in their everyday classroom interactions and strategies. Interviews consisted of two teachers and an educational assistant from one Northern Ontario classroom while participant observation was conducted for a period of seven weeks. Drawing from the framework of loose coupling and inhabited institution, this study finds that teachers actively negotiate policy in the face of classroom reality by drawing upon personal and social resources. Drawing from their previous experiences and some of their educational training they create, and implement strategies in dealing with learning diversity. Teachers felt enthusiastic about inclusion but their ideas ranged as to what it looked like; on top of their creativity in strategy making they also expressed the need for more resources and support to ensure the success of inclusion within their classrooms.

  15. Rural electrification in Zambia: A policy and institutional analysis

    International Nuclear Information System (INIS)

    Haanyika, Charles M.

    2008-01-01

    Zambia is well endowed with hydropower and other energy resources, which could facilitate production of electricity for both urban and rural areas of the country. The country has an installed electricity generation capacity of 1786 MW and undeveloped hydropower potential of over 6000 MW. In the last few years, demand has been growing and it is anticipated to outstrip supply in 2008. The load growth is attributed to increased mining activities and development of the industrial base. The country is also endowed with abundant natural resources such as arable land, water, minerals and wildlife. With the available resource base, electricity along with other social and economic infrastructure such as roads and telecommunications could facilitate increased economic activities. In rural areas, electricity could be used for crop irrigation, agro-processing, small-scale mining and to facilitate tourism. However, rural electrification (RE) faces many challenges such as long distances from existing power stations to targeted rural areas, low population densities, high poverty levels and low skills availability. These and other factors have contributed to continued low levels of access to electricity in rural areas of the country. Measures so far undertaken to facilitate access to electricity in rural areas of Zambia include the adoption of a new National Energy Policy (NEP) in 1994. With regard to the electricity sector and RE in particular, the NEP was aimed at facilitating increased access by liberalising and restructuring the electricity market and promoting the use of low-cost technologies and decentralised renewable energies. To facilitate implementation of the new policy, the government established a legal and institutional framework by enacting new legislation, namely, the Electricity Act and the Energy Regulation Act in 1995. The Electricity Act provided for liberalisation and regulation of the electricity sector, while the Energy Regulation Act provided for the

  16. Strategies for Success: Open Access Policies at North American Educational Institutions

    Science.gov (United States)

    Fruin, Christine; Sutton, Shan

    2016-01-01

    Recognizing the paucity of quantitative and qualitative data from North American educational institutions that have pursued open access policies, the authors devised a survey to collect information on the characteristics of these institutions, as well as the elements of the open access policies, the methods of promoting these policies, faculty…

  17. Cluster Policy in the Light of Institutional Context—A Comparative Study of Transition Countries

    OpenAIRE

    Tine Lehmann; Maximilian Benner

    2015-01-01

    The business environment in transition countries is often extraordinarily challenging for companies. The transition process these countries find themselves in leads to constant changes in the institutional environment. Hence, institutional voids prevail. These institutional voids cause competitive disadvantages for small and medium enterprises. Cluster policy can address these competitive disadvantages. As cluster policy generally aims at supporting companies’ competitive advantage by spurrin...

  18. Institutional Culture and OER Policy: How Structure, Culture, and Agency Mediate OER Policy Potential in South African Universities

    Science.gov (United States)

    Cox, Glenda; Trotter, Henry

    2016-01-01

    Several scholars and organizations suggest that institutional policy is a key enabling factor for academics to contribute their teaching materials as open educational resources (OER). But given the diversity of institutions comprising the higher education sector--and the administrative and financial challenges facing many institutions in the…

  19. The effectiveness of sexual harassment policies and procedures at higher education institutions in South Africa

    OpenAIRE

    Pierre Joubert; Christo van Wyk; Sebastiaan Rothmann

    2011-01-01

    Orientation: Sexual harassment policies are generally in place in higher education institutions without any indication of its effectiveness as determined by the awareness of the policy. Research purpose: The aim of this study was to investigate the awareness levels of academic staff members at higher education institutions in South Africa of sexual harassment policies and procedures in their institutions. Motivation for the study: A number of high profile court cases emphasised the need for e...

  20. Prospects of liberalization for s&t policies in Russia: institutional analysis

    OpenAIRE

    Kirdina, Svetlana

    2010-01-01

    The objective of the paper is to defi ne the trajectory of economic institutional reforms in Russia as a framework of S&T policies. The methodology of this research is based upon the institutional matrices theory (Кирдина, 2001; Kirdina, 2003). The hypothesis claims that the institutional nature of Russia defi nes its prospects of liberalization and needs the active implementation of liberal market institutions policy only within a framework of modernization of redistributive state econom...

  1. China's policies on greening financial institutions: assessment and outlook

    NARCIS (Netherlands)

    Mol, A.P.J.

    2017-01-01

    Environmental protection and sustainability have a complex relationship with finances and financial institutions. Financial institutions such as banks, pension funds and insurance companies, are increasingly seen as of vital importance for reaching environmental and sustainability goals. Initially,

  2. Widening Participation in Higher Education: An Examination of the Factors Influencing Institutional Policy

    Science.gov (United States)

    Greenbank, Paul

    2006-01-01

    This article examines the factors influencing the development of widening participation policy in 16 higher education institutions (HEIs). It utilises documentary research, followed by interviews with key policy makers in three of the institutions: an "old" university, a "new" university and a college of higher education. The…

  3. Comparative Analysis of Institutional Policy Definitions of Plagiarism: A Pan-Canadian University Study

    Science.gov (United States)

    Eaton, Sarah Elaine

    2017-01-01

    This article shares the findings of a study investigating institutional policy definitions of plagiarism at twenty English-speaking Canadian universities. The types of primary sources consulted for this study included: (1) university academic calendars for 2016-2017, (2) institutional policies on academic misconduct, and (3) student academic codes…

  4. Extending IPY Data to a Wider Audience

    Science.gov (United States)

    Turrin, M.; Bell, R. E.; Pfirman, S. L.

    2010-12-01

    Perhaps the most significant IPY contribution to science education was the vast amount of data collected at the polar-regions on Earth systems and processes that was made immediately available to teachers and curriculum developers. Supplementing textbooks with the Internet as an education partner, allowed participating teachers to transform science education through: their use of current data as an integral component of their classroom teaching; their training of students to seek out data as evidence of Earth processes; and their instruction to students on how to validate sources and uses of data. Yet, for every teacher and student who has been part of this successful IPY outreach there are many more who have not been reached, don’t know how to include polar science into their coursework, or don’t comfortably work with data. Our experience with data education projects suggests that to reach the next round of students, teachers, educators and the wider adult population we need to translate this data so it is accessible through carefully constructed activities, simulations, and games. In addition we need to actively seek new partnership and outlet opportunities. The collected measurements tell us that our poles are warming on a human timescale. Using data to tell the story, the unambiguous signal of warming makes it accessible to a much broader audience. Our experience has shown that, for a novice population working with data, the educational effectiveness is significantly enhanced when the signal in the data is strong and the Earth processes are clear. Building upon IPY data and resources, focusing on the Earth’s changing climate, and working with partnerships developed over the last two years, Lamont has put together several new education and outreach collaborations. Our goal is to reach new audiences through: 1) Inventorying, Assessing and Planning - Through an NSF planning grant we are leveraging IPY connections and findings in a Polar Climate Education

  5. Approaches to developing the capacity of health policy analysis institutes: a comparative case study

    Directory of Open Access Journals (Sweden)

    Bennett Sara

    2012-03-01

    Full Text Available Abstract Objectives To review and assess (i the factors that facilitate the development of sustainable health policy analysis institutes in low and middle income countries and (ii the nature of external support for capacity development provided to such institutes. Methods Comparative case studies of six health policy analysis institutes (3 from Asia and 3 from Africa were conducted. In each region an NGO institute, an institute linked to government and a university based institute were included. Data collection comprised document review, semi-structured interviews with stakeholders and discussion of preliminary findings with institute staff. Findings The findings are organized around four key themes: (i Financial resources: three of the institutes had received substantial external grants at start-up, however two of these institutes subsequently collapsed. At all but one institute, reliance upon short term, donor funding, created high administrative costs and unpredictability. (ii Human resources: the retention of skilled human resources was perceived to be key to institute success but was problematic at all but one institute. In particular staff often moved to better paid positions elsewhere once having acquired necessary skills and experience, leaving remaining senior staff with heavy workloads. (iii Governance and management: board structures and roles varied according to the nature of institute ownership. Boards made important contributions to organizational capacity through promoting continuity, independence and fund raising. Routine management systems were typically perceived to be strong. (iv Networks: linkages to policy makers helped promote policy influences. External networks with other research organizations, particularly where these were longer term institutional collaborations helped promote capacity. Conclusions The development of strong in-country analytical and research capacity to guide health policy development is critical, yet

  6. Campus Sustainability Governance in Canada: A Content Analysis of Post-Secondary Institutions' Sustainability Policies

    Science.gov (United States)

    Vaughter, Philip; McKenzie, Marcia; Lidstone, Lauri; Wright, Tarah

    2016-01-01

    Purpose: This paper aims to provide an overview of a content analysis of sustainability policies from Canadian post-secondary education institutions. The paper reports findings on the orientations to sustainability evident in the policies; references to other policies within the documents; and other key themes on how sustainability is engaged in…

  7. Effect of delivery care user fee exemption policy on institutional ...

    African Journals Online (AJOL)

    Background: To improve access to skilled attendance at delivery and thereby reduce maternal mortality, the Government of Ghana introduced a policy exempting all women attending health facilities from paying delivery care fees. Objective: To examine the effect of the exemption policy on delivery-related maternal mortality.

  8. Economic instruments and clean water: Why institutions and policy design matter

    DEFF Research Database (Denmark)

    Andersen, Mikael Skou

    1994-01-01

    Since market-like policy instruments are usually applied within existing rules, institutions, and policy processes, the policy and administrative contexts in which they operate become important. These contexts are quite different from country to country, often more so than policymakers are aware of....... The national style of policymaking depends on the constitutional framework, the infrastructure of public authorities as well as the historical and cultural heritage, which are basic institutional premises that vary tremendously even between neighbouring western european countries....

  9. Economic instruments and clean water: Why institutions and policy design matter

    DEFF Research Database (Denmark)

    Andersen, Mikael Skou

    2001-01-01

    Since market-like policy instruments are usually applied within existing rules, institutions, and policy processes, the policy and administrative contexts in which they operate become important. These contexts are quite different from country to country, often more so than policymakers are aware of....... The national style of policymaking depends on the constitutional framework, the infrastructure of public authorities as well as the historical and cultural heritage, which are basic institutional premises that vary tremendously even between neighbouring western european countries....

  10. Cluster Policy in the Light of Institutional Context—A Comparative Study of Transition Countries

    Directory of Open Access Journals (Sweden)

    Tine Lehmann

    2015-10-01

    Full Text Available The business environment in transition countries is often extraordinarily challenging for companies. The transition process these countries find themselves in leads to constant changes in the institutional environment. Hence, institutional voids prevail. These institutional voids cause competitive disadvantages for small and medium enterprises. Cluster policy can address these competitive disadvantages. As cluster policy generally aims at supporting companies’ competitive advantage by spurring innovation and productivity, it can help to bridge institutional voids. This article’s research question aims at analyzing and comparing cluster policies in the institutional context of two transition countries (Serbia and Tunisia and analyzes to what extent cluster policies in these two countries are adapted to institutional voids prevailing there. The case studies offer insights into apparent difficulties of clusters in bridging formal institutional voids, as well as, notably, into the informal void of skill mismatches in the labor market. Still, for some specific voids, clusters do at least implicitly assume a bridging role. While the cluster policies examined do not explicitly target the institutional voids identified, cluster management can—in the course of time—align its service offering more closely with these voids. Bottom-up designed cluster policies can play an especially important role in such an evolution towards bridging institutional voids.

  11. Smoke-free policies in New Zealand public tertiary education institutions.

    Science.gov (United States)

    Robertson, Lindsay A; Marsh, L

    2015-04-01

    The Framework Convention on Tobacco Control mandates the creation of smoke-free environments to protect non-smokers from second-hand smoke and reduce demand for tobacco. We aimed to examine the extent and nature of smoke-free campus policies at tertiary education institutions throughout New Zealand, and examine the policy development process. Stage one comprised an audit and content analysis of smoke-free policies. In stage two, semi-structured telephone interviews were conducted to investigate the process of developing and implementing policies. Qualitative content analysis was undertaken on interview notes. Policies were identified for most institutions (n = 26/29), though varied widely in nature. Only nine mandated 100% smoke-free campuses without exceptions and few prohibited the sale of tobacco on campus, or connections with the tobacco industry. During interviews (n = 22/29), cited barriers to developing a 100% smoke-free policy included enforcement challenges and anticipated opposition from staff and students. However, participants from institutions with 100% smoke-free policies reported having encountered few challenges. Varying levels of compliance with 100% smoke-free policies were reported yet, overall, these policies were viewed as being effective. Smoke-free campus policies could be strengthened to better reflect a completely tobacco-free organization. Other institutions and workplaces could use these findings to develop 100% smoke-free policies. © The Author 2015. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  12. Developing a Policy on Institutional Research for Black Hawk College.

    Science.gov (United States)

    Quayle, Thomas; Stevens, Mary A.

    In order to study the general objectives, methods, and provisions for institutional research in the community college, this document surveys the pertinent literature and reviews institutional research practices at selected community colleges. In general, three basic governance structure models are identified which represent varying relationships…

  13. Research Productivity and Its Policy Implications in Higher Education Institutions

    Science.gov (United States)

    Quimbo, Maria Ana T.; Sulabo, Evangeline C.

    2014-01-01

    Responding to the Commission on Higher Education's development plan of enhancing research culture among higher education institutions, this study was conducted to analyze the research productivity of selected higher education institutions. It covered five state universities in the Philippines where a total of 377 randomly selected faculty members…

  14. The Development and Application of Policy-Based Tools for Institutional Green Buildings

    Science.gov (United States)

    Cupido, Anthony F.

    2010-01-01

    In 2008, APPA forwarded a Web-based survey on the author's behalf to all designated representatives of APPA member institutions. The purpose of the survey was to determine if institutional policies are an important criterion for an institution's sustainable building practices and the use of Leadership in Energy and Environmental Design (LEED[R]).…

  15. Teaching in IPI. Volume III. A Program of Teacher Preparation.

    Science.gov (United States)

    Moshy, Claire A.

    With information derived from IPI Placement Tests, Unit Pretests, Curriculum Embedded Tests (CET's) and Unit Posttests; student performance on prescribed IPI tests and skill sheets, and observation of students' behavior, the teacher should, after planning sessions, be able to initiate the building of a basis for instructional decision making in…

  16. IPI Science: A Teaching Revolution in the Making.

    Science.gov (United States)

    Klopfer, Leopold E.; Weber, Victor L., Jr.

    1969-01-01

    Individually Prescribed Instruction (IPI) represents a significant innovation in education because it is one of the first successful operations of individualized instruction on a systematic basis throughout an entire school from kindergarten through sixth grade. The aim of IPI is to have the student regularly experience successful learning so that…

  17. A Second Year Evaluation of Individualized Prescribed Instruction (IPI).

    Science.gov (United States)

    Bailek, Hilton M.; Castro, Barbra

    This evaluation report of IPI in its second year concentrates on three main points: student attitudes towards IPI, teacher and student classroom activity and interaction, and student achievement during the school year. An account of overall impressions concludes the report which does not attempt to formalize any conclusions. It stresses, however,…

  18. Policy and Prediction: The Case of Institutional Diversity in Romanian Higher Education

    Directory of Open Access Journals (Sweden)

    Lazăr Vlăsceanu

    2012-01-01

    Full Text Available Presenting key elements of post-1990 historical developments in the Romanian higher education system, the emphasis is put on recent (2011policies of increasing higher education institutional differentiation. The view is that, in policy design, due attention should be paid to both historical roots and predicted developments. Building on an institutional analysis approach, we put forward a theoretical model that aims to explore the predictive implications of some recently promoted higher education policies. These policies are expected to increase institutional differentiation at the systemic level and enhance quality in teaching and research at university level. The predictive capacity of a model of reference is tested against a concurrent model. The key assumption of the latter is that of considering higher education institutions (HEIs as “cooperative systems” that are unable to generate those outputs and outcomes that, by aggregation, would contribute to the construction of an institutionally diverse and heterogeneous higher education landscape.

  19. A Helping Hand: Individually Prescribed Instruction (IPI

    Directory of Open Access Journals (Sweden)

    Bernard W. Andrews

    2014-10-01

    Full Text Available Individually Prescribed Instruction (IPI is an approach to teaching that emphasizes the diagnosis of learning problems and the provision of prescriptive assignments to assist individual students overcome their difficulties.  When this strategy is employed effectively, the teaching environment is highly adaptive.  The teacher matches the students' abilities to alternate ways of learning, and also provides remedial assistance and positive reinforcement.  Individually Prescribed Instruction has been shown to be effective across the school curriculum.  This writer reviews the success of this strategy for assisting students overcome learning problems, and proposes a model for its implementation in music instruction.

  20. Reframing Rigor: Implications for Institutional Practice and Policy

    Science.gov (United States)

    Keller, Christine M.

    2018-01-01

    This chapter redefines rigor as academic challenge that supports student learning and growth can be a powerful lever to accelerate institutional efforts to increase educational attainment and close achievement gaps.

  1. Policy Reforms and Institutional Weakness : Closing The Gap.

    OpenAIRE

    Gilberto M. Llanto; Eduardo T. Gonzalez

    2007-01-01

    The promise and potential of the Philippine economy has remained unrealized notwithstanding the countrys talented labor force, skilled professionals and relatively abundant resources. What ails the Philippines? This paper argues that the incompetence and downright corruption of Philippine institutions have much to do with the countrys dismal performance in economic growth and poverty reduction. It draws attention to the significance of effective institutional and regulatory frameworks in orch...

  2. No Policy for Public Private Partnership? PPP, Collaboration and Institutions

    DEFF Research Database (Denmark)

    Tolstrup Christensen, Lene; Greve, Carsten

    The paper examines how the PPP‐policy has developed in a country with low PPP activity. The paper focuses on the following research questions: How does collaboration occur between the public and private sector in relation to the provision of transport infrastructure and public service? How does...... infrastructure projects and public service provision contracts in the transport sector within roads and busses, bridges and tunnels, rail, airports and aviation and harbors. The projects will be categorized in relation to organizational and financial models and it leads to a. discussion of types of policy...

  3. Interim18F-FDG PET/CT improves the prognostic value of S-IPI, R-IPI and NCCN-IPI in patients with diffuse large B-cell lymphoma.

    Science.gov (United States)

    Jiang, Maoqing; Chen, Ping; Ruan, Xinzhong; Ye, Xianwang; Pan, Yuning; Zhang, Jie; Huang, Qiuli; Zhou, Wenlan; Wu, Hubing; Wang, Quanshi

    2017-12-01

    The current study aimed to explore whether the efficiency of the standard International Prognostic Index (S-IPI), revised-IPI (R-IPI) and enhanced-IPI (NCCN-IPI) in evaluating the prognosis of patients with diffuse large B-cell lymphoma (DLBCL) may be improved by interim 18 F-FDG PET/CT. A total of 185 patients with newly diagnosed DLBCL were enrolled in the current study. All patients underwent interim PET/CT following the 4th cycle of chemotherapy. Patients were divided into different risk groups using S-IPI, R-IPI and NCCN-IPI and further subdivided into risk groups using interim PET/CT. Interpretations were evaluated for 2-year progression-free survival (PFS) and overall survival (OS). With a median follow-up time of 44 months, the 2-year PFS and OS were 60% [95% confidence interval (CI) 53-67%] and 81% (95% CI 74-86%), respectively. Analysis of S-IPI and NCCN-IPI identified no significant difference in PFS and OS between high intermediate and high risk groups. However, there were significant differences in the PFS and OS between the low and low intermediate risk groups (PIPI, interim PET/CT identified a significant difference between PFS and OS in the good and poor risk groups but not in the very good risk group. Therefore, the results of the current study indicate that S-IPI, R-IPI and NCCN-IPI are three clinically useful prognostic indexes for patients with DLBCL. Interim PET/CT may improve the prognostic value of S-IPI, R-IPI and NCCN-IPI in predicting 2-year PFS and OS, particularly in patients with a high IPI score.

  4. TTI Phase 2 Institutional Support: Centre for Policy Dialogue | CRDI ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    For CPD, this project will help enhance its research quality, organizational performance, and policy engagement. Centre of excellence. Through this support over the next 4.5 years, CPD is expected to -give a voice to the interests and concerns of low-income and least-developed countries in national, regional, and global ...

  5. Input-output theory and institutional aspects of environmental policy

    NARCIS (Netherlands)

    Steenge, A.E.

    1999-01-01

    National accounting over the years has developed in close interaction with input–output analysis. However, present developments involving core and satellite accounts seem to suggest that this relation will become less close, with possible negative consequences for analysis and policy. In this paper

  6. Analyzing the influence of institutions on health policy development ...

    African Journals Online (AJOL)

    Background: During the 2001 election campaign, President Yoweri Museveni announced he was abolishing user fees for health services in Uganda. No analysis has been carried out to explain how he was able to initiate such an important policy decision without encountering any immediate barriers. Objective: To explain ...

  7. Evolving institutional and policy frameworks to support adaptation strategies

    Science.gov (United States)

    Dave Cleaves

    2014-01-01

    Given the consequences and opportunities of the Anthropocene, what is our underlying theory or vision of successful adaptation? This essay discusses the building blocks of this theory, and how will we translate this theory into guiding principles for management and policy.

  8. An Eclectic Theory of Entrepreneurship: Policies, Institutions and Culture

    NARCIS (Netherlands)

    I. Verheul (Ingrid); A.R.M. Wennekers (Sander); D.B. Audretsch (David); A.R. Thurik (Roy)

    2001-01-01

    textabstractThe level of entrepreneurship differs considerably across countries and periods. Both the causes and consequences of entrepreneurship are a matter of extensive scientific debate as well as of great policy importance. A high level of entrepreneurial activity is assumed and shown to

  9. International trade and carbon emissions: The role of Chinese institutional and policy reforms.

    Science.gov (United States)

    Andersson, Fredrik N G

    2018-01-01

    The carbon dioxide embodied in Chinese exports to developed countries increased rapidly from 1995 to 2008. We test the extent to which institutional reforms in China can explain this increase. We focus on five areas of reforms: trade liberalization, environmental institutions, legal and property rights, institutional risk and exchange rate policy. Our results show that trade liberalization, weak environmental institutions, exchange rate policy, and legal and property rights affect emissions. Our results also indicate that the lack of reform in the utilities sector is an important factor in the rapid increase in embodied emissions. Copyright © 2017 Elsevier Ltd. All rights reserved.

  10. The Effectiveness of Private Forest Institutional and Policy in Banjarnegara and Banyumas Regency

    Directory of Open Access Journals (Sweden)

    Eva Fauziyah

    2017-12-01

    Full Text Available This research aimed to analyze the effectiveness of institusional and policy on private forest. The research was conducted in Banjarnegara and Banyumas Regency in August 2012 - May 2013. The methods used in this study are structured interview, open interview and Focus Group Discussion (FGD. Assessment of institutional effectiveness was done to government institutional, marketing institututional, and farmer institutional using recommended indicator namely: 1 user and resource boundaries, 2 appropriation and provision, 3 collective-choice arrangements, 4 monitoring, 5 graduated sanctions, 6 conflict-resolution mechanisms, and 7 recognition of appropriators’ rights to organize. The collected data were processed using likert scale and analyzed descriptively. The results showed that effectiveness of institutional in Kabupaten Banjarnegara and Banyumas Regency was moderate condition (quite effective. The effectiveness of private forest policy is seen from four policy viewpoints: policy accuracy, policy implementation, target accuracy, and environmental accuracy. Private forest policy in Kabupaten Banjarnegara is effective based on policy accuracy and environmental accuracy, while private forest policy in Banyumas Regency is effective based on target accuracy and environmental accuracy. This difference in assessment is due to the different of policy or program at the location according to the condition and the desire of community.

  11. Experiments with the Ignitor Pellet Injector (IPI)

    Science.gov (United States)

    Frattolillo, A.; Migliori, S.; Podda, S.; Bombarda, F.; Baylor, L. R.; Caughman, J. B. O.; Combs, S. K.; Foust, C.; Fehling, D.; McJill, J. M.; Meitner, S.; Roveta, G.

    2009-11-01

    The four barrel, two-stage pneumatic injector for the Ignitor experiment (IPI), built by ENEA and ORNL, has been tested in the course of three esperimental campaigns. The optimal shaping of the propellant pressure pulse to improve pellet acceleration is provided by specially designed Pulse Shaping Valves. These have been modified and tested on a new facility that allows operating pellet injector components in conditions close to those at which they will have to operate on the IPI. Fast closing (< 10 ms) valves drastically reduce the expansion volumes needed to remove the propellant gas at the end of the guiding tube. The four barrel (2.1, 2.2, 3.0 and 4.6 mm bores) pipe-gun cryostat is cooled down by a closed cycle refrigerator, and pellet diagnostics for measuring speed and mass of the pellets, as well as for capturing in-flight pictures of all four pellets were developed for this application. The final impact target is equipped with a shock accelerometer. The injector is designed to deliver pellets with velocities up to 4 km/s (2 km/s already achieved): the results of the latest experimental campaign will be reported.

  12. Hansen's disease in the state of Amazonas: policy and institutional treatment of a disease.

    Science.gov (United States)

    Schweickardt, Julio Cesar; Xerez, Luena Matheus de

    2015-12-01

    This article discusses the historical aspects of the policies for controlling Hansen's disease in the state of Amazonas from the second half of the nineteenth century until the dismantling of this model in 1978. We present the historical changes in the local institutions and policies, and their relationship with national policies. The history and policies related to Hansen's disease in the state of Amazonas are analyzed through the following institutions: Umirisal, the Oswaldo Cruz Dispensary, the Paricatuba Leprosarium, the Antônio Aleixo Colony, and the Gustavo Capanema Preventorium. We seek to show that these institutions cared for the people who suffered from Hansen's disease and those related to them, and were also responsible for carrying out the policies for fighting and controlling the disease.

  13. International Financial Institution Policies of Conditionality and Public Pedagogy

    Science.gov (United States)

    MacPhail, Scott; McGray, Robert

    2014-01-01

    Conditionalities are most broadly defined as the provisos that are to be met by a country when borrowing money from the International Financial Institutions (IFIs). Increasingly, they have proven to have far reaching consequences for countries entering into agreements with The World Bank, the International Monetary Fund, and the World Trade…

  14. Reviewing Institutional Policies for Electronic Management of Assessment

    Science.gov (United States)

    Voce, Julie

    2015-01-01

    Electronic assignment submission (e-submission) tools, such as those within course management systems (e.g. Blackboard), or systems such as Turnitin, which enable students to submit coursework online are now one of the main centrally supported institutional tools in Higher Education (HE) in the United Kingdom (UK), however the development of…

  15. The Policy Choices of Bureaucrats: an institutional analysis

    NARCIS (Netherlands)

    S. Naseer (Shaheen)

    2018-01-01

    textabstractThis dissertation analyzes the over-arching question of how the institutional and social context of public bureaucracy impact the choices of bureaucrats. These choices are introduced in the form of inertial-preferences and identity-driven preferences in the decision-making of

  16. Policy research institutions and the health SDGs: Open data ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Successful achievement of the 17 sustainable development goals (SDGs) and 169 targets will require the participation of citizens that use and rely on local public services. Citizens have ... CEGSS will also mentor institutions in India, Peru, and Mexico that are establishing similar web-based monitoring systems. This project ...

  17. Institutional Support to Latin American Policy Research Organizations

    International Development Research Centre (IDRC) Digital Library (Canada)

    This grant will strengthen the ability of the 12 selected research institutions to provide, disseminate and communicate high-quality research. This will be achieved through measures aimed at enhancing the ability of staff to conduct sound research, improving organizational governance, and communicating with policymakers.

  18. An Eclectic Theory of Entrepreneurship: Policies, Institutions and Culture

    OpenAIRE

    Ingrid Verheul; Sander Wennekers; David Audretsch; Roy Thurik

    2001-01-01

    textabstractThe level of entrepreneurship differs considerably across countries and periods. Both the causes and consequences of entrepreneurship are a matter of extensive scientific debate as well as of great policy importance. A high level of entrepreneurial activity is assumed and shown to contribute to innovative activities, competition, economic growth and job creation. The present paper deals with the determinants of entrepreneurship. An eclectic theory of entrepreneurship is introduced...

  19. Encouraging the Arts through Higher Education Institutions: Arts Policy Implementation in Virginia

    OpenAIRE

    Keeney, Katherine Preston

    2014-01-01

    This dissertation investigates the role of public higher education institutions in state-level arts policy in the state of Virginia. The strength of public support for the arts historically has been measured by per capita arts spending, as determined by appropriations to state arts agencies. However, this is a very thin measure that misses an increasingly important contributor to the arts policy landscape - higher education institutions. As direct sources of funding for the arts decline, univ...

  20. Institutional Role in Gunung Walat Educational Forest Policy: Discourse and Historical Approaches

    Directory of Open Access Journals (Sweden)

    Yulius Hero

    2012-08-01

    Full Text Available Institutional science with various approaches have been used in analysing forest policy at international level and in Indonesia. This research used institutional science with discourse and historical approach for the policy of Forest Territory with Special Purpose (Kawasan Hutan dengan Tujuan Khusus, KHDTK. This research study the KHDTK case of Gunung Walat Educational Forest (Hutan Pendidikan Gunung Walat, HPGW. The goal of this research is to understand discourse/narration of policy and describe the policy space for HPGW and KHDTK. Institutional analysis in this research used discourse and historical approach. Discourse analysis used IDS model supported with Wittmer-Birner model and Eden-Ackermann diagram. On the other hand,  historical approach used the historical relationship. The research outcome showed that the process of creating HPGW policy is not linear, but being affected by policy discourse/narration in the process of creating HPGW policy. Faculty of Forestry IPB has been successfully managing HPGW because of the success to build policy discourse/narration which is supported by the knowledge of HPGW managers, cooperation network, and interest and power.  Meanwhile, external party perceived and believed the importance of HPGW management for forestry education. The success key of HPGW policy is in structuring the institution that control the behavior of HPGW managers, so the managers obtained trust from third parties to create interest alliances which can boost HPGW management performance. HPGW policy can be used to fulfill KHDTK policy space according to Article 8, Forestry Law Number 41 Year 1999.Keywords: discourse, history, institution, Gunung Walat Educational Forest (HPGW, forest territory with special purpose (KHDTK

  1. From Clusters to Smart Specialization: Tourism in Institution-Sensitive Regional Development Policies

    Directory of Open Access Journals (Sweden)

    Maximilian Benner

    2017-07-01

    Full Text Available In the European Union and its neighborhood, regional development has increasingly come to focus on agglomerations during the last three decades. Notably, during the 1990s and early 2000s, clustering was the major policy focus in regional development. Currently, the concept of smart specialization is applied all over the European Union and is attracting interest in the EU’s neighborhood. The tourism sector particularly tends to agglomerate regionally and even locally. While there is a large body of literature describing tourism clusters and while tourism features as a priority sector in many regional development strategies such as smart specialization strategies, there is a research gap on policy approaches applying agglomeration-oriented policy concepts to tourism destinations in an institution-sensitive way. This article argues that both cluster policy and smart specialization can be of considerable value for institution-sensitive tourism development, either when adapted to the specificities of the tourism sector or when integrating tourism development into wider, cross-sectoral strategies of regional development. Such a policy can be a valuable tool for local and regional development, provided that policies are designed in an institution-sensitive manner and respond to the particular institutional context prevailing in a tourist destination. The article illustrates some preliminary thoughts for institution-sensitive tourism development through cluster policy and smart specialization in Cyprus, Israel, and Tunisia.

  2. Climate Change and the Canadian Higher Education System: An Institutional Policy Analysis

    Science.gov (United States)

    Henderson, Joseph; Bieler, Andrew; McKenzie, Marcia

    2017-01-01

    Climate change is a pressing concern. Higher education can address the challenge, but systematic analyses of climate change in education policy are sparse. This paper addresses this gap in the literature by reporting on how Canadian postsecondary educational institutions have engaged with climate change through policy actions. We used descriptive…

  3. “Soft Power” of Foreign Policy Activity of the USA: Institutions and Mechanisms of Formation

    Directory of Open Access Journals (Sweden)

    Ольга Александровна Фролова

    2013-12-01

    Full Text Available The main institutes and mechanism of soft power policy, its preconditions and formation are being considered in this article. In the end author comes to conclusion that nowadays it’s more appropriate to talk about smart power in context of US’ foreign policy.

  4. Advancing the climate agenda: Exploiting material and institutional linkages to develop a menu of policy options

    NARCIS (Netherlands)

    van Asselt, H.D.; Gupta, J.; Biermann, F.

    2005-01-01

    The utilization of interlinkages of existing material and the strengthening and promotion of new institutional interlinkages can widen the climate change agenda through new and innovative policy and legal measures. Material linkages are inherent structural connections between policy domains that are

  5. Adjusting policy to institutional, cultural and biophysical context conditions: The case of conservation banking in California

    Science.gov (United States)

    Carsten Mann; James D. Absher

    2013-01-01

    This paper examines the political construction of a policy instrument for matching particular institutional, biophysical and cultural context conditions in a social–ecological system, using the case of conservation banking in California as an example. The guiding research question is: How is policy design negotiated between various actors on its way from early...

  6. Image policy of Russia: institutional and technological measurements

    Directory of Open Access Journals (Sweden)

    T. V. Shirochenko

    2014-07-01

    Full Text Available The article examines the main state institutions, which are responsible for the formation of Russia’s image, estimation of their activity and the effectiveness of their activities. It analyses the main normative documents that regulating the activities of state institutions in the direction of forming the image of the country. Considered the most influential media institutions that have a direct influence on what will be the image of the Russian Federation in the perception of the international community. It analyses the activities of the most influential in Russia Internet-resources, TV channels, information agencies, radio. Learn the basic techniques and methods that are used to form a positive image of the Russian Federation. Analyzed the activities of international forums, created under the auspices of Russia, and their impact on the perception of Russia in the world. Provides a list and description of the most prominent Russian and foreign cultural projects implemented in many countries.Describes the activities of the most influential Russian funds, the purpose of which is to restore the interest to the Russian culture abroad. Considerable attention is paid to the methods of influence on public opinion and shaping the image of Russia in the context of recent developments, namely the Russian aggression in Ukraine.

  7. Market-oriented institutions and policies and economic growth : A critical survey

    NARCIS (Netherlands)

    De Haan, J; Lundstrom, S; Sturm, JE

    This paper surveys recent evidence suggesting that market-oriented institutions and policies are strongly related to economic growth, focusing on studies using the economic freedom (EF) indicator of the Fraser Institute. This index is critically discussed. Also various serious shortcomings of

  8. 34 CFR 668.46 - Institutional security policies and crime statistics.

    Science.gov (United States)

    2010-07-01

    ... Institutional and Financial Assistance Information for Students § 668.46 Institutional security policies and... security of and access to campus facilities, including campus residences, and security considerations used... concerning who should be contacted, the importance of preserving evidence for the proof of a criminal offense...

  9. Politics in India: A Research Bibliography on Indian Political Institutions, Behavior and Public Policy Issues.

    Science.gov (United States)

    Mohapatra, Urmila

    This bibliography is a classified list of published research material on the contemporary Indian political system. The research references assembled have been organized under three broad categories: Indian political institutions, Indian political behavior, and public policy issues. The political institutions section focuses on the presidency,…

  10. Small States and Big Institutions: USAID and Education Policy Formation in El Salvador

    Science.gov (United States)

    Edwards, D. Brent, Jr.

    2012-01-01

    This article analyses the institutional power of the United States Agency for International Development (USAID) in the process of education policy formation in El Salvador during 2003-2005. The results show how bi- and multi-lateral institutions are able to leverage financial and intellectual capital to guide the policymaking process and sway…

  11. Introducing Widening Participation Policies in Higher Education: The Influence of Institutional Culture

    Science.gov (United States)

    Greenbank, Paul

    2007-01-01

    This paper examines the role of culture in the development of higher education institution (HEI) policy on widening participation. The study involved documentary research and interviews with senior and middle managers. It suggests that a culture of widening participation is often not embedded throughout institutions. Therefore, widening…

  12. Grid-connected renewable energy in China: Policies and institutions under gradualism, developmentalism, and socialism

    International Nuclear Information System (INIS)

    García, Clara

    2011-01-01

    This communication displays some of our on-going research on the incompleteness of China's advances toward “best practice” in policy-making and institution-building for renewables. In particular, this paper: (1) summarizes how Chinese policies and institutions for the deployment of renewable electricity are only partially compliant with what is internationally recognized as “best practice”; and (2) contextualizes Chinese policies and institutions for renewables in the broader picture of China's political economy. Much as a political economy perspective has aided the understanding of why Chinese economic reforms were partial and unique, the said contextualization might help explain why China's policies and institutions for renewables diverge from “best practice”. Further, given that China proved successful in promoting its economic growth with partial and unique reforms, the partiality and uniqueness of its renewables policies and institutions need not impede the rapid development of renewable electricity. This on-going research has so far combined a review of specialized literature and the business press with semi-structured interviews held with relevant actors in policy, business, and research related to renewable energies.

  13. Does Federal Financial Aid Policy Influence the Institutional Aid Policies of Four-Year Colleges and Universities? An Exploratory Analysis

    Science.gov (United States)

    Hossler, Don; Kwon, Jihye

    2015-01-01

    There is a dearth of empirical work that examines the relationships between federal financial aid policy and institutional financial aid priorities and expenditures. This study uses Resource Dependency Theory to explore whether changes the amount of financial aid awarded by colleges and universities during the last fifty years are best explained…

  14. Can Historical Institutionalism Explain the Reforms of the Common Agricultural Policy?

    Directory of Open Access Journals (Sweden)

    Nicoleta Lăşan

    2012-03-01

    Full Text Available Historical institutionalism, one of the three variants of new institutionalism, has been largely employed by scholars to explain the development of one of the first policies developed at the European level, namely the Common Agricultural Policy (CAP. Due to historical institutionalism’s claim that policies tend to follow the path set at their creation, it is not surprising that it could easily account for the development of the CAP before 1990s since this was one of the most resistant policies set by the member states of the European Union. The main challenge for historical institutionalism is to explain the shifts that occurred in this policy due to the reforms agreed after 1990, reforms that are often mentioned in the literature as being crucial. The aim of this paper is to show that historical institutionalism can accommodate the 1992 and 2003 reforms of the Common Agricultural Policy, and from this we can infer that the changes needed to adapt this policy of the EU to the conditions of an ever enlarging Europe will take place slowly, if at all.

  15. The role of common pool resource institutions in the implementation of Swiss natural resource management policy

    Directory of Open Access Journals (Sweden)

    Jean-David Gerber

    2008-07-01

    Full Text Available By analysing Swiss common pool resource (CPR institutions, this paper aims to contribute to the debate on comanagement while demonstrating how important it is to take into account the structuring role played by public policies in the regulation of natural resource use in western countries characterized by significant state intervention. The comparative analysis of three detailed case studies dealing with hunting, flood protection and landscape management policies leads to three main conclusions: (1 CPR institutions strengthen the coherence of resource regimes to the extent that they constitute social institutions which can facilitate the "mediation process," i.e. the transformation of the collective identity, self-perception and, therefore, behaviour of policy target groups in the direction defined by the stated policy objectives; (2 one of the main conditions for the perpetuation of CPR institutions is their capacity to organize their activities around a collective problem defined as such by a policy; (3 the integration of CPR institutions into the political-administrative arrangement contributes to the reinforcement of the functional and territorial coordination between payers, decision makers and beneficiaries in regional and local institutional regimes.

  16. Structure and genomic organization of the ipiB and ipiO gene clusters of Phytophthora infestans

    OpenAIRE

    Pieterse, C.M.J.; West, P. van; Verbakel, H.M.; Brassé, P.W.H.M.; Berg-Velthuis, G.C.M. van den; Govers, F.

    1994-01-01

    Two in planta-induced (ipi) genes, designated ipiB and ipiO, of the potato late blight fungus, Phytophthora infestans (Mont.) de Bary, were isolated from a genomic library by a differential hybridization procedure [Pieterse et al., Physiol. Mol. Plant Pathol. (1993a) in press]. Both genes are expressed at high levels in the early phases of the pathogenic interaction of P. infestans with its host plant potato, suggesting that their gene products have a function in the early stages of the infec...

  17. The Institutional Component of the Efficient Economic Policy of the State

    Directory of Open Access Journals (Sweden)

    Mykytas Viktoriia V

    2016-01-01

    Full Text Available The article substantiates the necessity of institutional accompanying the economic policy of the State, establishing an efficient system of institutions. Challenges of the contemporary globalization require changes in the State influence on economy, redefining quality parameters and principles of an efficient economic policy. Complexity of the State policy in a global environment is determined not only by importance of the tasks of establishing an efficient market against the background of increasing influences of exogenous uncertainty, but also by seeking ways of entering the global space, thus implementing the best interests of national economic development. The article deduces parameters of the concept of «efficient institution». The author believes that institutions precisely should act as the link through which social and economic development would become unseparated in order to form a stable efficient socio-economic development

  18. Written institutional ethics policies on euthanasia: an empirical-based organizational-ethical framework.

    Science.gov (United States)

    Lemiengre, Joke; Dierckx de Casterlé, Bernadette; Schotsmans, Paul; Gastmans, Chris

    2014-05-01

    As euthanasia has become a widely debated issue in many Western countries, hospitals and nursing homes especially are increasingly being confronted with this ethically sensitive societal issue. The focus of this paper is how healthcare institutions can deal with euthanasia requests on an organizational level by means of a written institutional ethics policy. The general aim is to make a critical analysis whether these policies can be considered as organizational-ethical instruments that support healthcare institutions to take their institutional responsibility for dealing with euthanasia requests. By means of an interpretative analysis, we conducted a process of reinterpretation of results of former Belgian empirical studies on written institutional ethics policies on euthanasia in dialogue with the existing international literature. The study findings revealed that legal regulations, ethical and care-oriented aspects strongly affected the development, the content, and the impact of written institutional ethics policies on euthanasia. Hence, these three cornerstones-law, care and ethics-constituted the basis for the empirical-based organizational-ethical framework for written institutional ethics policies on euthanasia that is presented in this paper. However, having a euthanasia policy does not automatically lead to more legal transparency, or to a more professional and ethical care practice. The study findings suggest that the development and implementation of an ethics policy on euthanasia as an organizational-ethical instrument should be considered as a dynamic process. Administrators and ethics committees must take responsibility to actively create an ethical climate supporting care providers who have to deal with ethical dilemmas in their practice.

  19. Conceptual and Institutional Aspects of EU Energy Policy (1990-2014

    Directory of Open Access Journals (Sweden)

    Yury V. Borovskiy

    2015-01-01

    Full Text Available Ideological and institutional framework of the European energy policy, which is still work in progress, is crucial to the EU as it faces new political and economic challenges related to the recent Ukrainian crisis. Even if key energy policy issues are still decided by member states as the EU only seeks to speak with one voice in energy matters externally, much progress has been made over the last two decades in terms of the EU's energy policy formulation and institutional development. The Lisbon Treaty made the energy policy a sphere of "shared competence" of EU institutions and member states. The European Commission's numerous policy documents ("White" and "Green books" 1995, 2000 and 2006 provided a basis for the development of an integrated energy market. Substantial progress has been achieved in the area of energy policy harmonization between the EU and neighboring countries (Energy Charter Treaty, European Energy Community. The Union's key energy policy areas also included supply diversification (trans-European energy networks, development of unconventional energy production, climate change and energy efficiency. Over the last decade climate changes has become a cornerstone of EU energy policy and is regarded by the EU as key to moderating energy demand and reducing import dependency.

  20. Institutional and policy responses to uncertainty in environmental policy: A comparison of dutch and US styles

    NARCIS (Netherlands)

    Arentsen, Maarten J.; Bressers, Johannes T.A.; O'Toole, Laurence J.

    2000-01-01

    Uncertainties regarding problem definition and policy response are an endemic pan of environmental decisionmaking. Some standard responses to uncertainty in decisionmaking are analyzed and then used to suggest the importance of learning-oriented policy processes in open, flexible, and adaptive

  1. Interim 18F-FDG PET/CT improves the prognostic value of S-IPI, R-IPI and NCCN-IPI in patients with diffuse large B-cell lymphoma

    OpenAIRE

    Jiang, Maoqing; Chen, Ping; Ruan, Xinzhong; Ye, Xianwang; Pan, Yuning; Zhang, Jie; Huang, Qiuli; Zhou, Wenlan; Wu, Hubing; Wang, Quanshi

    2017-01-01

    The current study aimed to explore whether the efficiency of the standard International Prognostic Index (S-IPI), revised-IPI (R-IPI) and enhanced-IPI (NCCN-IPI) in evaluating the prognosis of patients with diffuse large B-cell lymphoma (DLBCL) may be improved by interim 18F-FDG PET/CT. A total of 185 patients with newly diagnosed DLBCL were enrolled in the current study. All patients underwent interim PET/CT following the 4th cycle of chemotherapy. Patients were divided into different risk g...

  2. Russia's natural gas policy toward Northeast Asia: Rationales, objectives and institutions

    International Nuclear Information System (INIS)

    Shadrina, Elena

    2014-01-01

    The article examines the institutional dimensions of Russia's gas policy toward Northeast Asia (NEA During the liberal economic reforms of the 1990s, development of natural gas deposits in the Russian Far East was made possible under the scheme of production sharing agreements (PSA). However, new PSAs were banned in Russia even before the advent of state capitalism in the early 2000s. This was, to a large extent, the result of strong anti-PSA lobbying led by the domestic energy business elite. Consequently, Russia's gas policy in the east began evolving from being project-specific toward being region-specific. Contemporary Russian gas policy toward NEA relies upon domestic (national and regional) and external institutions. In 2009, following the completion of a liquefied natural gas (LNG) plant in Sakhalin, Russia entered NEA gas markets. Transformations in the international gas markets facilitated the establishment of a two-pattern gas export policy in Russia in 2013. Under this policy, Russia's EU-oriented pipeline gas export remains monopolised by Gazprom, while Asia-oriented LNG export is partially liberalised. Russia has not been experiencing institutional discrepancy in NEA gas markets. However, as the markets evolve toward greater coordination, a rational option for Russia is to genuinely liberalise its gas policy. - Highlights: • Russia–EU institutional inconsistency has accelerated Russia's gas export diversification. • Institutions for regional development are an important component of Russia's gas policy in Asia. • Transformations in globalising gas markets induced Russia's limited gas export liberalisation. • Genuine gas policy liberalisation can facilitate the attainment of Russia's goals in Asia

  3. Dynamic mobility applications policy analysis : policy and institutional issues for intelligent network flow optimization (INFLO).

    Science.gov (United States)

    2014-12-01

    The report documents policy considerations for the Intelligent Network Flow Optimization (INFLO) connected vehicle applications : bundle. INFLO aims to optimize network flow on freeways and arterials by informing motorists of existing and impen...

  4. The effectiveness of sexual harassment policies and procedures at higher education institutions in South Africa

    Directory of Open Access Journals (Sweden)

    Pierre Joubert

    2011-02-01

    Research purpose: The aim of this study was to investigate the awareness levels of academic staff members at higher education institutions in South Africa of sexual harassment policies and procedures in their institutions. Motivation for the study: A number of high profile court cases emphasised the need for effective policies to reduce the incidence of sexual harassment complaints. Research design, approach and method: A cross-sectional survey design was conducted amongst 161 academic staff members, representing 10 higher education institutions in South Africa. The measuring instrument that was used is the Sexual Harassment Questionnaire (SHQ that was developed specifically for this study. Main findings: The results showed that despite indications that sexual harassment policies do exist and that they are regarded as effective tools in addressing sexual harassment, the implementation of such policies is not effective and few academic staff members received training and/or guidance on the utilisation of the policy. Significant correlation coefficients were found between the elements of an effective policy and between population group and some of the elements. Practical/managerial implications: Employers across the board should regularly conduct an audit to determine the level of awareness of sexual harassment policies and procedures and plan interventions. Contribution: No other study in South Africa attempted to measure the awareness levels of academics and its impact on the management of sexual harassment.

  5. Expression of the Phytophthora infestans ipiB and ipiO genes in planta and in vitro

    OpenAIRE

    Pieterse, C.M.J.; Derksen, A.-M.C.E.; Folders, J.; Govers, F.

    1994-01-01

    The ipiB and ipiO genes of the potato late blight fungus Phytophthora infestans (Mont.) de Bary were isolated from a genomic library in a screen for genes induced in planta. Expression of these genes was studied during pathogenesis on various host tissues and different host plants, some of which show specific resistance against P. infestans infection. During pathogenesis on leaves and tubers of the fully susceptible potato cultivar (cv.) Ajax and on leaves of the fully susceptible tomato cv. ...

  6. The Impact of Global Institutions on National Health HIV/AIDS Policy Making in Developing Countries

    Directory of Open Access Journals (Sweden)

    Zhanat Mokushev

    2013-09-01

    Full Text Available This article explores the relationship of global institutions such as the International Monetary Fund, World Trade Organization, World Bank, and individual developing countries in social health policy making in terms of HIV and AIDS. We examine the role of IGOs and NGOs in regarding to HIV/AIDS issues then analyse the TRIPs agreement as a tool for developing countries to negotiate with International organisations in global health policy decisions.

  7. Bulgaria’s Institutions and Policies : Integrating into Pan-European Markets

    OpenAIRE

    Kaminski, Bartlomiej

    2006-01-01

    This paper analyzes the process of institutional transformation in Bulgaria and assesses the extent to which it has established institutions and policies fostering domestic economic activity and integration into global markets. After a brief review of characteristics and achieved progress in first-generation reforms, that is, removal of central control over prices, liberalization of foreign trade and exchange rate regimes, the paper first assesses in the comparative perspective the progress m...

  8. The Political Economy of the European Union: Institutions, Policy and Economic Growth

    DEFF Research Database (Denmark)

    Svendsen, Gert Tinggaard

    . Focusing in detail on international climate negotiations and wind energy, the author explores the way in which the design of a policy proposal can be affected by the interactions between interest groups and the institutions and bureaucrats of the EU. The case of greenhouse gas emissions trading is a unique...... and decision makers. It will also interest and inform a wide readership in the social sciences, particularly those with an interest in the institutional structure of the EU....

  9. Policies and Institutional Supports for Women Entrepreneurship Development in Bangladesh: Achievements and Challenges

    Directory of Open Access Journals (Sweden)

    Golam Rabbani

    2016-01-01

    research researchers relied solely on the secondary sources. The study revealed that Government agencies provide policy, legal and financial support with active support from non-State actors. On the contrary, they do not get proper support from all relevant institutions because of corruption and lack of information. It is suggested that combined initiatives of Government and nongovernment institutions will be successful in meeting the needs of business women in Bangladesh.

  10. Family control, institutional environment and cash dividend policy: Evidence from China

    OpenAIRE

    Zhihua Wei; Shinong Wu; Changqing Li; Wei Chen

    2011-01-01

    Using a sample of 1486 Chinese A-share listed companies for the period 2004–2008, this study empirically tests the impact of family control, institutional environment and their interaction on the cash dividend policy of listed companies. Our results indicate that (1) family firms have a lower cash dividend payout ratio and propensity to pay dividends than non-family firms; (2) a favorable regional institutional environment has a significant positive impact on the cash dividend payout ratio an...

  11. Enabling sustainable urban road transport in China: A policy and institutional perspective

    International Nuclear Information System (INIS)

    Zhang, Xiliang; Hu, Xiaojun

    2003-01-01

    The paper is an effort to investigate the approach to sustainable urban road transport in Chinese mega cities with an emphasis on policy and institutional perspectives. The study links the major ''unsustainabilities'' of China's urban road transport with those deficiencies in urban road transport planning and management and China's auto industry policy and gives some suggestions and recommendations for policy change and adjustment. The paper also provides some examples of successful experiences from foreign cities in urban road transport development from which Chinese cities can learn. (Author)

  12. Enabling sustainable urban road transport in China: A policy and institutional perspective

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Xiliang; Hu, Xiaojun

    2003-07-01

    The paper is an effort to investigate the approach to sustainable urban road transport in Chinese mega cities with an emphasis on policy and institutional perspectives. The study links the major ''unsustainabilities'' of China's urban road transport with those deficiencies in urban road transport planning and management and China's auto industry policy and gives some suggestions and recommendations for policy change and adjustment. The paper also provides some examples of successful experiences from foreign cities in urban road transport development from which Chinese cities can learn. (Author)

  13. The National Institute of Public Health: Shaping Public Policy to Advance Population Health in Mexico

    Directory of Open Access Journals (Sweden)

    Laura Magaña-Valladares

    2011-01-01

    Full Text Available The Mexican School of Public Health was founded in 1922 by the Mexican government and was the first school of public health in Latin America. It has become one of the largest public health institutions in the developing world and is the leading institution for teaching, research and service to improve public health in Mexico and Latin America. The Institute is an important player in shaping public policy in Mexico through its mission-oriented research. Through its research initiatives, the Institute has influenced policies regarding tobacco, obesity, milk and flour fortification, malaria, cancer, environmental health, and other public health priority areas. The Institute responds to changing health workforce training needs. It currently offers 28 competency-based graduate degree programs and trains annually more than 10,000 in-service public health workers through continuing education courses. The Institute offers multiple educational formats to accomplish its mission, including face-to-face, virtual, and blended learning. It has been accredited by both national and international agencies and collaborates closely with international institutions. The Institute contributes to global health by promoting health equity, strengthening health systems, and generating evidence-based strategies to improve population health in Mexico, the Americas, and around the world.

  14. The Oregon Public Health Policy Institute: Building Competencies for Public Health Practice

    Science.gov (United States)

    Yoon, Jangho; Bernell, Stephanie; Tynan, Michael; Alvarado, Carla Sarai; Eversole, Tom; Mosbaek, Craig; Beathard, Candice

    2015-01-01

    The Oregon Public Health Policy Institute (PHPI) was designed to enhance public health policy competencies among state and local health department staff. The Oregon Health Authority funded the College of Public Health and Human Sciences at Oregon State University to develop the PHPI curriculum in 2012 and offer it to participants from 4 state public health programs and 5 local health departments in 2013. The curriculum interspersed short instructional sessions on policy development, implementation, and evaluation with longer hands-on team exercises in which participants applied these skills to policy topics their teams had selected. Panel discussions provided insights from legislators and senior Oregon health experts. Participants reported statistically significant increases in public health policy competencies and high satisfaction with PHPI overall. PMID:26066925

  15. 34 CFR 668.49 - Institutional fire safety policies and fire statistics.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false Institutional fire safety policies and fire statistics... fire statistics. (a) Additional definitions that apply to this section. Cause of fire: The factor or... statistics described in paragraph (c) of this section. (2) A description of each on-campus student housing...

  16. Institutions policies and soil degradation:theoretical examinations and case studies in Southeast China

    NARCIS (Netherlands)

    Tan, S.; Qu Futian,; Huang Xianjin,; Heerink, N.B.M.

    2004-01-01

    Southeast China is one of the severe soil degradation areas in China. Taking this area for example, this paper examines theoretically the impact of some important institutional arrangements and policies like land management pattern, the rural off-farm employment, land property change and changes in

  17. Enacting Effective Climate Policy Advice: Institutional Strategies to Foster Saliency, Credibility and Legitimacy

    Science.gov (United States)

    Bauer, Anja; Pregernig, Michael; Reinecke, Sabine

    2016-01-01

    This article asks how scientific advisory institutions (SAIs) in climate policy strive towards effectiveness. Our analysis is grounded on the assumption that effectiveness is not passively experienced but is deliberately enacted by SAIs. We draw on a widely used set of criteria, namely saliency, credibility and legitimacy (SCL). Based on an…

  18. Political and Institutional Drivers of Social Security Policy in South Africa

    DEFF Research Database (Denmark)

    S. Ulriksen, Marianne; Plagerson, Sophie

    This paper provides an analysis of political and institutional drivers that shape social policy in South Africa with a specific focus on social security. As elsewhere in the Global South, South Africa has a quite extensive social assistance framework, whereas social insurance is limited...

  19. Administrative Practices as Institutional Identity: Bureaucratic Impediments to HE "Internationalisation" Policy in Japan

    Science.gov (United States)

    Poole, Gregory S.

    2016-01-01

    This paper explores how bureaucracy impedes the implementation of higher education (HE) policy at Japanese universities. Administrative systems employ Weberian legal-rational bureaucratic practices that are central to the institutional identity of a university. Rather than the means to internationalisation and reform in general, these systems…

  20. The Structure of Promotion and Tenure Decisions in Institutions of Higher Education: A Policy Analysis.

    Science.gov (United States)

    Lincoln, Yvonna S.

    1983-01-01

    The rationale underlying the promotion-tenure process needs to be adequately analyzed since many institutions' policies appear undifferentiated on the principles of merit and worth. Sorting the decisions, devising appropriate and open criteria, and applying those criteria consistently are advocated. Guidelines are outlined. (MLW)

  1. Learning to listen. Institutional change and legitimation in UK radioactive waste policy

    Energy Technology Data Exchange (ETDEWEB)

    Mackerron, G. [SPRU Science and Technology Policy Research, University of Sussex, Brighton (United Kingdom); Berkhout, F. [Institute for Environmental Studies IVM, VU University, Amsterdam (Netherlands)

    2009-04-15

    Over the course of 50 years, UK radioactive waste policy change has been coupled with institutional change, without much progress towards the ultimate goal of safe, long-term stewardship of wastes. We explain this history as a search for legitimacy against a shifting context of legitimation needs and deficits. Following Habermas, we argue that legitimation is derived from a process of justificatory discourse. In principle, there must be a reasonable exchange of arguments between diverse parties in society, based on common norms, for legitimacy to be achieved. We show that the work of legitimation in UK radioactive waste policy has moved from a focus on factual validity claims towards an increasing emphasis on deliberative processes. This reframing of legitimation needs explains institutional and policy changes in UK radioactive waste policy. The most recent phase of policy and institutional change, which placed public deliberation about long-term management and disposal options centre-stage, represents a new step towards bridging legitimation deficits. Plans to build new nuclear reactors in the UK based on a more closed 'streamlined' decision process risk reversing the legitimacy gains that have been achieved through growing openness on radioactive waste management.

  2. Organ donation in the ICU: A document analysis of institutional policies, protocols, and order sets.

    Science.gov (United States)

    Oczkowski, Simon J W; Centofanti, John E; Durepos, Pamela; Arseneau, Erika; Kelecevic, Julija; Cook, Deborah J; Meade, Maureen O

    2018-04-01

    To better understand how local policies influence organ donation rates. We conducted a document analysis of our ICU organ donation policies, protocols and order sets. We used a systematic search of our institution's policy library to identify documents related to organ donation. We used Mindnode software to create a publication timeline, basic statistics to describe document characteristics, and qualitative content analysis to extract document themes. Documents were retrieved from Hamilton Health Sciences, an academic hospital system with a high volume of organ donation, from database inception to October 2015. We retrieved 12 active organ donation documents, including six protocols, two policies, two order sets, and two unclassified documents, a majority (75%) after the introduction of donation after circulatory death in 2006. Four major themes emerged: organ donation process, quality of care, patient and family-centred care, and the role of the institution. These themes indicate areas where documented institutional standards may be beneficial. Further research is necessary to determine the relationship of local policies, protocols, and order sets to actual organ donation practices, and to identify barriers and facilitators to improving donation rates. Copyright © 2017 Elsevier Ltd. All rights reserved.

  3. Simplicity at the cost of predictive accuracy in diffuse large B-cell lymphoma: a critical assessment of the R-IPI, IPI, and NCCN-IPI.

    Science.gov (United States)

    Biccler, Jorne; Eloranta, Sandra; de Nully Brown, Peter; Frederiksen, Henrik; Jerkeman, Mats; Smedby, Karin E; Bøgsted, Martin; El-Galaly, Tarec C

    2018-01-01

    The international prognostic index (IPI) and similar models form the cornerstone of clinical assessment in newly diagnosed diffuse large B-cell lymphoma (DLBCL). While being simple and convenient to use, their inadequate use of the available clinical data is a major weakness. In this study, we compared performance of the International Prognostic Index (IPI) and its variations (R-IPI and NCCN-IPI) to a Cox proportional hazards (CPH) model using the same covariates in nondichotomized form. All models were tested in 4863 newly diagnosed DLBCL patients from population-based Nordic registers. The CPH model led to a substantial increase in predictive accuracy as compared to conventional prognostic scores when evaluated by the area under the curve and other relevant tests. Furthermore, the generation of patient-specific survival curves rather than assigning patients to one of few predefined risk groups is a relevant step toward personalized management and treatment. A test-version is available on lymphomapredictor.org. © 2017 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

  4. A model rights and ownership of educational materials policy for institutions.

    Science.gov (United States)

    Audette, L G

    1980-03-01

    This paper reports a survey taken of 79 college and university medical schools seeking the status of policy formation regarding in-house created educational materials at each location. About 65% (51) of the institutions had no definitive policies, but over half of those were aware of the need. Twenty-six provided either written documents or a narrative describing how they approach the problem. Only two recognized the special area of media production. A model policy was synthesized from the aggregate. The model provides for support and recognition of creative service units and a philosophical framework upon which the entire group, including content experts, production staff, and parent institution, can share income and recognition equitably.

  5. Radioactive waste: institutional determinants of management and disposal policy in three European countries

    International Nuclear Information System (INIS)

    Berkhout, Frans.

    1989-01-01

    The objective of this thesis has been to write a detailed historical account of the policy and practice of radioactive waste management in Britain, Sweden and West Germany, and to draw out implications for theory and public policy. By comparing the evolution of the policy process in three countries it has been possible to develop a better understanding of the particular operational, regulatory and political factors determining policy in each case. The main conclusions are three-fold. First, the presence or absence of commitments to the reprocessing of spent fuel for a wide range of strategic, industrial and legal reasons have been critical to the success in finding an acceptable radwaste management and disposal policy (or strategy). Politically it is not possible to make a clear distinction between radwaste management and policy for the rest of the back-end of the nuclear fuel cycle. Second, because of this complex but intimate relationship to reprocessing policy, the dynamism and consistency of radwaste policies are highly dependent on the industrial and political contexts of the drive to reprocessing. Traditionally a view on reprocessing has been virtually synonymous with a faith or scepticism in the future of nuclear power. Third, the policy process, and indeed its goals was rather unique to national circumstances (the legal and institutional framework, industrial and political structures). This demonstrates one of the principle arguments of the thesis which is that the innovation process for radwaste management and disposal technologies cannot be seen merely as a technical process, but has to be seen as a process of political and institutional negotiations. (author)

  6. Policies and institutions for moderating deep recessions, debt crises and financial instabilities

    Directory of Open Access Journals (Sweden)

    O’Hara Phillip Anthony

    2013-01-01

    Full Text Available This paper outlines a long-term policy and institutional framework for reducing the intensity of recessions, debt crises and financial instabilities, especially for the Core nations and areas that bore the brunt of the anomalies during 2008-2013. We argue that institutional changes need to be systemic, amounting to the construction of a new social structure of accumulation (SSA or mode of regulation (MOR, which we call an SSA of embedded communitarian liberalism. Five institutional spheres are introduced which are in need of systemic change, due to the entrenched contradictions and problems which the current set of institutions generate. These involve firstly institutions within the world-system of finance and production; secondly relating to finance versus industry; thirdly capital versus labor; fourthly state systems of production; and fifthly the interlinking of state, community and ecology.

  7. Molecular determinants of resistance activation and suppression by Phytophthora infestans effector IPI-O.

    Science.gov (United States)

    Chen, Yu; Liu, Zhenyu; Halterman, Dennis A

    2012-01-01

    Despite intensive breeding efforts, potato late blight, caused by the oomycete pathogen Phytophthora infestans, remains a threat to potato production worldwide because newly evolved pathogen strains have consistently overcome major resistance genes. The potato RB gene, derived from the wild species Solanum bulbocastanum, confers resistance to most P. infestans strains through recognition of members of the pathogen effector family IPI-O. While the majority of IPI-O proteins are recognized by RB to elicit resistance (e.g. IPI-O1, IPI-O2), some family members are able to elude detection (e.g. IPI-O4). In addition, IPI-O4 blocks recognition of IPI-O1, leading to inactivation of RB-mediated programmed cell death. Here, we report results that elucidate molecular mechanisms governing resistance elicitation or suppression of RB by IPI-O. Our data indicate self-association of the RB coiled coil (CC) domain as well as a physical interaction between this domain and the effectors IPI-O4 and IPI-O1. We identified four amino acids within IPI-O that are critical for interaction with the RB CC domain and one of these amino acids, at position 129, determines hypersensitive response (HR) elicitation in planta. IPI-O1 mutant L129P fails to induce HR in presence of RB while IPI-O4 P129L gains the ability to induce an HR. Like IPI-O4, IPI-O1 L129P is also able to suppress the HR mediated by RB, indicating a critical step in the evolution of this gene family. Our results point to a model in which IPI-O effectors can affect RB function through interaction with the RB CC domain.

  8. Political and institutional influences on the use of evidence in public health policy. A systematic review.

    Directory of Open Access Journals (Sweden)

    Marco Liverani

    Full Text Available BACKGROUND: There is increasing recognition that the development of evidence-informed health policy is not only a technical problem of knowledge exchange or translation, but also a political challenge. Yet, while political scientists have long considered the nature of political systems, the role of institutional structures, and the political contestation of policy issues as central to understanding policy decisions, these issues remain largely unexplored by scholars of evidence-informed policy making. METHODS: We conducted a systematic review of empirical studies that examined the influence of key features of political systems and institutional mechanisms on evidence use, and contextual factors that may contribute to the politicisation of health evidence. Eligible studies were identified through searches of seven health and social sciences databases, websites of relevant organisations, the British Library database, and manual searches of academic journals. Relevant findings were extracted using a uniform data extraction tool and synthesised by narrative review. FINDINGS: 56 studies were selected for inclusion. Relevant political and institutional aspects affecting the use of health evidence included the level of state centralisation and democratisation, the influence of external donors and organisations, the organisation and function of bureaucracies, and the framing of evidence in relation to social norms and values. However, our understanding of such influences remains piecemeal given the limited number of empirical analyses on this subject, the paucity of comparative works, and the limited consideration of political and institutional theory in these studies. CONCLUSIONS: This review highlights the need for a more explicit engagement with the political and institutional factors affecting the use of health evidence in decision-making. A more nuanced understanding of evidence use in health policy making requires both additional empirical studies

  9. An appraisal of policies and institutional frameworks impacting on smallholder agricultural water management in Zimbabwe

    Science.gov (United States)

    Nyagumbo, I.; Rurinda, J.

    Policies and institutional frameworks associated with and / or impacting on agricultural water management (AWM) in smallholder farming systems in Zimbabwe were analyzed through literature reviews, feedback from stakeholder workshops, key informant interviews and evaluation of policy impacts on implemented case study projects/programmes. The study showed that Zimbabwe has gone a long way towards developing a water management policy addressing both equity and access, through the Water and ZINWA of 1998. However, lack of incentives for improving efficient management and utilization of water resources once water has reached the farm gate was apparent, apart from punitive economic instruments levied on usage of increased volumes of water. For example, the new water reforms of 1998 penalized water savers through loss of any unused water in their permits to other users. In addition, the ability of smallholder farmers to access water for irrigation or other purposes was influenced by macro and micro-economic policies such as Economic Structural and Adjustment Programme (ESAP), Zimbabwe Programme for Economic and Social Transformation (ZIMPREST), prevailing monetary and fiscal policies, as well as the Land and Agrarian Reform policies. For instance, the implementation of ESAP from 1991 to 95 resulted in a decline in government support to management of communal irrigation schemes, and as a result only gravity-fed schemes survived. Also AWM projects/programmes that were in progress were prematurely terminated. While considerable emphasis was placed on rehabilitation of irrigation infrastructure since the fast track land reform in 1998, the policies remained rather silent on strategies for water management in rainfed systems. The piecemeal nature and fragmentation of policies and institutional frameworks scattered across government ministries and sectors were complex and created difficulties for smallholder farmers to access water resources. Poor policy implementation

  10. The highest prognostic impact of LDH among International Prognostic Indices (IPIs): an explorative study of five IPI factors among patients with DLBCL in the era of rituximab.

    Science.gov (United States)

    Park, J H; Yoon, D H; Kim, D Y; Kim, S; Seo, S; Jeong, Y; Lee, S W; Park, C S; Huh, J; Suh, C

    2014-10-01

    Although the International Prognostic Index (IPI) is considered as the current standard prognostication system for diffuse large B-cell lymphoma (DLBCL), prognostic heterogeneity is suggested to exist among the patients within the same IPI risk group. Hence, we investigated the pattern of distribution and prognostic impact of five IPI factors within the same IPI score. We retrospectively reviewed the medical records of 387 patients newly diagnosed as pathologically proven DLBCL between February 2002 and February 2010. We classified patients to IPI risk scores and categorized them according to the combinations of IPI. Then, we explored the frequency of five IPI factors and analyzed the correlation between these subgroups and efficacy outcomes: complete response (CR), event-free survival (EFS), and overall survival (OS). Survival estimates by IPI score in this cohort corresponded to the classic IPI. Elevated serum level of lactate dehydrogenase (LDH) was the most prevalently distributed factor throughout the scores, and patients with elevated serum level of LDH tended to have lower CR, inferior EFS, and/or OS irrespective of IPI scores. Particularly, among the subgroups of IPI score of 2, elevated serum level of LDH was significantly associated with inferior CR (73.1 vs 95.2 %), 3-year EFS (57 vs 87 %), and 3-year OS (58 vs 82 %). In addition, the higher serum level of LDH, particularly above 2,000 IU/L, was significantly correlated with the inferior survival outcomes (3-year EFS 78.0 vs 58.5 vs 45.5 vs 20.0 %, 3-year OS 86.0 vs 66.2 vs 58.2 vs 40.0 %). In conclusion, among five factors of IPI, elevated serum level of LDH seems to be the most frequently distributed and, more importantly, the most relevant IPI factor with the highest prognostic impact. These findings still warrant further validation in larger cohorts.

  11. The value of Integrated Pulmonary Index (IPI) monitoring during endoscopies in children.

    Science.gov (United States)

    Garah, Jamal; Adiv, Orly Eshach; Rosen, Irit; Shaoul, Ron

    2015-12-01

    The Integrated Pulmonary Index (IPI) is an algorithm included in commercially available monitors that constitutes a representation of 4 parameters: EtCO2, RR, SpO2 and PR. The IPI index has been validated for adults and children older than 1 year of age. In this study we aimed to study the value of IPI monitoring during pediatric endoscopic procedures. Our data consisted of 124 measurements of 109 patients undergoing different procedures (upper endoscopy 84 patients, colonoscopy 6 patients, both 9 patients). The data was divided into 3 groups based on the drug type used: propofol only, 5 patients (group 1); propofol & midazolam, 89 patients (group 2); propofol, midazolam and Fentanyl, 15 patients (group 3). Patients in group 2 and 3 had significantly higher IPI levels than group 1. Significantly lower IPI values were found between ages 4-6 compared to 7-12 years old. High midazolam dose was associated with lower IPI levels during the procedure. No significant differences were found for propofol doses. Patients who had an anesthetist present had lower IPI levels during the procedure compared to those who did not. No differences were noted between the different procedures. IPI alerted all apnea episodes (58 events, IPI = 1) and hypoxia (26 events, IPI ≤ 3) episodes, whereas pulse oximetry captured only the hypoxia episodes (IPI sensitivity = 1, specificity 0.98, positive predictive value 0.95). Younger patient age, use of propofol alone, higher midazolam doses and presence of anesthetist are all associated with lower IPI levels.

  12. ASSESSMENT OF SOCIO-ORIENTED POLICY IN BANKING INSTITUTIONS OF UKRAINE

    Directory of Open Access Journals (Sweden)

    Lunkina Tatyana

    2018-01-01

    Full Text Available Introduction. In today’s globalized conditions, the question of socially responsible business and the formation of an appropriate concept and policies for managing it are more relevant. Scientists are investigating this issue in two aspects, namely, from a theoretical and practical point of view. The first aspect is the study of the essence of CSR, the conduct of entrepreneurial activity, the functioning mechanism of the market principles in this concept, the definition of the place of social orientation in modern conditions. The second aspect is the study of practical positions, the separation of this concept from the standpoint of warning and risk management, assessment of the level of social responsibility and summing up the rating, summarizing all the results, as well as the establishment of a standard that will regulate such relationships. But, in our opinion, the implementation of such socially-oriented moments is not possible without identifying a certain number of indicators, reflecting the real situation and the impact of social factors on the banking institutions. This explains the relevance of studying the assessment of socially-oriented policies of banking institutions. Purpose. The purpose of this article is to determine the approaches to the assessment of socially-oriented policies of banking institutions, as well as to determine the place of rating assessment in the current conditions of the functioning of institutions and organizations. Results. The article describes approaches of socially-oriented banking policy in Ukraine. A quantitative approach is drawn, which directly includes the assessment of the level of social investment through the conduct of socially responsible activities by banking institutions. The qualitative approach according to which social reports and social ratings are compiled is investigated. The social indicators that influence the formation of a socially oriented political management system by business

  13. Optimizing Communications Between Arctic Residents and IPY Scientific Researchers

    Science.gov (United States)

    Stapleton, M.; Carpenter, L.

    2007-12-01

    BACKGROUND International Polar Year, which was launched in March 2007, is an international program of coordinated, interdisciplinary scientific research on Earth's polar regions. The northern regions of the eight Arctic States (Canada, Alaska (USA), Russia, Sweden, Norway, Finland. Iceland and Greenland (Denmark) have significant indigenous populations. The circumpolar Arctic is one of the least technologically connected regions in the world, although Canada and others have been pioneers in developing and suing Information and Communication Technology (ICT) in remote areas. The people living in this vast geographic area have been moving toward taking their rightful place in the global information society, but are dependent on the outreach and cooperation of larger mainstream societies. The dominant medium of communication is radio, which is flexible in accommodating multiple cultures, languages, and factors of time and distance. The addition of newer technologies such as streaming on the Internet can increase access and content for all communities of interest, north and south. The Arctic Circle of Indigenous Communicators (ACIC) is an independent association of professional Northern indigenous media workers in the print, radio, television, film and Internet industries. ACIC advocates the development of all forms of communication in circumpolar North areas. It is international in scope. Members are literate in English, French, Russian and many indigenous languages. ACIC has proposed the establishment of a headquarters for monitoring IPY projects are in each area, and the use of community radio broadcasters to collect and disseminate information about IPY. The cooperation of Team IPY at the University of Colorado, Arctic Net at Laval University, and others, is being developed. ACIC is committed to making scientific knowledge gained in IPY accessible to those most affected - residents of the Arctic. ABSTRACT The meeting of the American Geophysical Union will be held

  14. Valuing energy policy attributes for environmental management: Choice experiment evidence from a research institution

    International Nuclear Information System (INIS)

    Komarek, Timothy M.; Lupi, Frank; Kaplowitz, Michael D.

    2011-01-01

    Many governments, firms, institutions and individuals have become increasingly cognizant of their impact on the environment, most notably with respect to global climate change. Coupled with the possibility of future regulations aimed at curbing greenhouse gas emissions, firms and institutions have begun to critically evaluate their own carbon footprint. This paper examines the preferences of stakeholders within a large academic institution for attributes of alternative greenhouse gas (GHG) reduction strategies. The attributes considered by constituents include: the fuel portfolio mix, effort for conserving energy use, carbon emissions reduction, timeframe for emissions reduction to be achieved and cost. We use a choice experiment technique that enables the examination of greenhouse gas reduction program attribute preferences across three constituent groups. The results show that each of the constituent groups have a positive WTP for carbon emissions reductions and prefer investments in reductions in the shorter- rather than longer-term. The results also suggest differences between the constituent groups in their WTP for types of fuels in the fuel portfolio. Finally, we use the results to examine the welfare implications of different combinations of the policy attributes that coincide with alternative GHG program strategies. - Highlights: → We explore preferences for carbon footprint reduction at an academic institution. → Include several pertinent energy policy attributes in a choice experiment. → Find preference heterogeneity between constituent groups for policy attributes. → Find highest willingness to pay for 'green' energy and emissions reduction amount.

  15. Conflict of interest policies among institutions and organizations offering chiropractic continuing education.

    Science.gov (United States)

    Funk, Matthew F; Lisi, Anthony J

    2009-05-01

    The purpose of this study is to document and describe the policies governing conflict of interest (COI) among select organizations and institutions offering chiropractic continuing education. Surveys were sent to the following: all North American chiropractic colleges; major national chiropractic organizations; and state chiropractic organizations in states with more than 3500 licensed Doctors of Chiropractic. Each organization or institution was surveyed regarding written and verbal COI policies. Half of the respondents in this survey indicated that they had written policies for management of COI, whereas half did not. None included most of the common elements typically outlined in continuing medical education COI policies. Content varied among the policies available for review. Relevant financial interest is the issue most often defined, and respondents generally prohibit presenters from selling products or services directly during presentations. Overall, these results suggest that processes for managing COI in chiropractic CE are less robust than those previously described for continuing medical education. This study provides preliminary insight into the status of COI management in chiropractic CE.

  16. The competences of European Union institutions in the trade policy (Lisbon Treaty

    Directory of Open Access Journals (Sweden)

    Margareta Timbur

    2010-12-01

    Full Text Available The European Union is the best known at the world’s leading trade power and the common trade policy is the core of EU external relations. The events of the last years and the extension of the EU to 27 member proved that the functioning system could no longer continue and was requiring a new institutional framework. The Lisbon Treaty was the right solution. It purposes are to bring changes for the citizens, institutions, external relations foe the consolidation of democracy in EU. This paper attempts to provide an overview of the major revisions introduced by the Treaty of Lisbon regarding the trade policy. Also, it analyses the extension and clarification of EU competence, the greater role of the European Parliament and the inclusion of investment policy in trade policy, the voting rules in trade area and the international negotiation of trade agreements. The study describes, as well, the impact of Lisbon Treaty implementation on the MS which are independent nations, but without power of decision in the common trade policy.

  17. Institutional Knots: A Comparative Analysis of Cord Blood Policy in Canada and the United States.

    Science.gov (United States)

    Denburg, Avram

    2016-02-01

    Umbilical cord blood is a rich source of blood stem cells, which are of critical clinical importance in the treatment of a variety of malignant and genetic conditions requiring stem cell transplantation. Many countries have established national public cord blood banks; such banks often coexist with a panoply of private options for cord blood banking. Until recently, Canada was the only G8 country without a national cord blood bank. This differs markedly from the United States, which years ago established a national cord blood bank policy and inventory. This article investigates potential reasons for this discrepancy through a comparative analysis of the evolution of programs and policies on national cord blood banking in Canada and the United States. My analysis suggests that cross-national discrepancies in policy on public cord blood banking were determined primarily by institutional factors, principal among them formal governmental structure and the legacy of past policies. Institutional entrepreneurialism in the health sector played a constitutive role in the earlier evolution of national cord blood policy in the United States as compared to Canada. Copyright © 2016 by Duke University Press.

  18. The institutional configuration of sport policy in Brazil: organization, evolution and dilemmas

    Directory of Open Access Journals (Sweden)

    Alessandra Mendes

    2015-06-01

    Full Text Available Brazil has become the center of the spotlight of the whole world recently, amongst many other reasons, one of them was because it was chosen to host a series of mega sporting events - Pan American Games in 2007, Confederations Football Cup in 2013, Fifa Football World Cup 2014 Games and 2016 Olympic and Paralympic Games in 2016. However, little is known about the country's administrative governmental structure focused on sport policy. The available studies focus their analysis on the sport policies content, but not on the arrangement of its structural decision-making. The main aim of this article is indeed to describe, based on official documentation, the evolution and the current arrangements of the government responsible for the administrative structure for the planning and implementation of sports policies in Brazil. Thus, we tried to list the main problems arising from the organization of the Brazilian sports' management. These problems are: (1 inappropriate institutional structure in terms of human resources and obstacles to participation by other social actors beyond the officials (parliament and members of the Ministry of Sports in the sports policy; (2 disarticulation between public institutions generating redundancies and conflicts of jurisdiction due to the poor division of labor between bureaucracy agencies; and (3 inadequate planning proved by the lack of organization of some institutions, and by the lack of assessment and continuity of public policies over time. Therefore, we must emphasize those problems from above, and due to these administrative arrangements, Brazilian sports' policy has big challenges in the sport development in this country, which includes the creation of a national "system" for sports and a priority investment in sport education.

  19. Outcome prediction by extranodal involvement, IPI, and R-IPI in the PET/CT and rituximab era

    DEFF Research Database (Denmark)

    El-Galaly, Tarec Christoffer; Villa, Diego; Alzahrani, Musa

    2015-01-01

    PURPOSE: 18F-fluorodeoxyglucose PET/CT (PET/CT) is the current state-of-the-art in the staging of diffuse large B-cell lymphoma (DLBCL) and has a high sensitivity for extranodal involvement. Therefore, reassessment of extranodal involvement and the current prognostic indices in the PET/CT era...... met the inclusion criteria. With a median follow-up of 2.4 years, the 3-year overall (OS) and progression-free survival (PFS) were 73% and 69%, respectively. The Ann Arbor classification had no prognostic impact in itself with the exception of stage IV disease (HR 2.14 for PFS, P... with a dismal outcome. The IPI, R-IPI, and NCCN-IPI predict outcome with high accuracy. This article is protected by copyright. All rights reserved....

  20. Climate policy studies by the Fridtjof Nansen Institute, ECON and Energy Data:10 Abstracts

    International Nuclear Information System (INIS)

    Andresen, S.; Eikeland, P.O.; Eleri, E.O.; Fermann, G.; Fredriksen, O.; Halseth, A.; Hansen, S.; Haugland, T.; Malnes, R.; Skjaerseth, J.B.; Ottosen, R.

    1993-01-01

    The overall focus is the relation between energy, environment and development on the national level and international co-operation concerning sustainable energy management and global environmental change. A series of country studies analyses the economic, political and institutional factors influencing energy, environment and climate policies. The role of non-state actors like NGOs and the energy industries in international environmental affairs is also closely examined. Strategies to enhance energy efficiency are studied with a particular focus on identifying and overcoming barriers to policy implementation. The ways in which developments in international energy markets affect the potential and scope of international environmental agreements are analysed, as are the impacts of different international environmental regimes on energy markets. Particular attention is paid on the opportunities and limitations of international institutions like the European Community, the United Nations, the multilateral development banks and GATT, in promoting international co-operation on energy and environmental issues. Strategies to overcome North/South conflicts over global environmental issues are examined, including issue linkages in international negotiations and North/South transfer of resources and technology. Another important area of sustainable production and consumption of energy in developing countries. Project titles are: 1) ''Leader'' and ''entrepreneur'' in international negotiations . A conceptual analysis. 2) Choosing climate policy. Decision theoretical premises. 3) Japan in the greenhouse responsibilities, policies and prospects for combating global warming. 4) Impacts on developing economies from changing trade regimes and growing international environmental concerns. 5) US energy policy in the greenhouse from the North slope forests to the Gulf Stream waters - this land was made for fossil fuels. 6) The climate policy of the EC - too hot to handle. 7) US climate

  1. Climate policy studies by the Fridtjof Nansen Institute, ECON and Energy Data:10 Abstracts

    Energy Technology Data Exchange (ETDEWEB)

    Andresen, S.; Eikeland, P.O.; Eleri, E.O.; Fermann, G.; Fredriksen, O.; Halseth, A.; Hansen, S.; Haugland, T.; Malnes, R.; Skjaerseth, J.B.; Ottosen, R

    1993-07-01

    The overall focus is the relation between energy, environment and development on the national level and international co-operation concerning sustainable energy management and global environmental change. A series of country studies analyses the economic, political and institutional factors influencing energy, environment and climate policies. The role of non-state actors like NGOs and the energy industries in international environmental affairs is also closely examined. Strategies to enhance energy efficiency are studied with a particular focus on identifying and overcoming barriers to policy implementation. The ways in which developments in international energy markets affect the potential and scope of international environmental agreements are analysed, as are the impacts of different international environmental regimes on energy markets. Particular attention is paid on the opportunities and limitations of international institutions like the European Community, the United Nations, the multilateral development banks and GATT, in promoting international co-operation on energy and environmental issues. Strategies to overcome North/South conflicts over global environmental issues are examined, including issue linkages in international negotiations and North/South transfer of resources and technology. Another important area of sustainable production and consumption of energy in developing countries. Project titles are: 1) ''Leader'' and ''entrepreneur'' in international negotiations . A conceptual analysis. 2) Choosing climate policy. Decision theoretical premises. 3) Japan in the greenhouse responsibilities, policies and prospects for combating global warming. 4) Impacts on developing economies from changing trade regimes and growing international environmental concerns. 5) US energy policy in the greenhouse from the North slope forests to the Gulf Stream waters - this land was made for fossil fuels. 6) The climate policy of

  2. Policy Design for Competitive Retail Electric Institutions: Artificial Intelligence Representations for a Common Property Resource Approach

    Science.gov (United States)

    Pandit, Nitin S.

    The U.S. electricity industry is being restructured to increase competition. Although existing policies may lead to efficient wholesale institutions, designing policies for the retail level is more complex because of intricate interactions between individuals and quasi-monopolistic institutions. It is argued that Hirshman's ideas of "exit" and "voice" (Hirshman, 1970) provide powerful abstractions for design of retail institutions. While competition is a known mechanism of "exit," a novel design of the "voice" mechanism is demonstrated through an artificial intelligence (AI) based software process model. The process model of "voice" in retail institutions is designed within the economic context of electricity distribution -- a common property resource (CPR), characterized by technological uncertainty and path-dependency. First, it is argued that participant feedback (voice) has to be used effectively to manage the CPR. Further, it is noted that the decision process, of using participant feedback (voice) to incrementally manage uncertainty and path-dependencies, is non-monotonic because it requires the decision makers to often retract previously made assumptions and decisions. An AI based process model of "voice" is developed using an assumption-based truth maintenance system. The model can emulate the non-monotonic decision making process and therefore assist in decision support. Such a systematic framework is flexible, consistent, and easily reorganized as assumptions change. It can provide an effective, formal "voice" mechanism to the retail customers and improve institutional performance.

  3. From Good Governance to Developmental Governance - How Policies, Institutions and Politics Matter

    DEFF Research Database (Denmark)

    Lauridsen, Laurids Sandager

    2012-01-01

    The present global financial and economic crisis offers an opportunity to rethink the relative roles of state and market as well as of globalisation and national development strategies in the political economy of development. It has become more difficult to argue that globalisation has rendered...... national development strategies and in particular industrial policies superfluous. The crisis also calls for a rethinking of the prevailing standard recipes for development and of the ‘institutional therapy’ that has been driven by the international development establishment. The article seeks to identify...... and outline a heterodox view on how policies, institutions and politics matter for latecomer development, and does that by juxtaposing it with the orthodox view. The central argument of the article is that the orthodox view has serious weaknesses, and that a heterodox approach – developmental governance...

  4. Sexual harassment, special relationships and consensual engagement policies within higher learning institutions : a labour law perspective

    OpenAIRE

    2015-01-01

    LL.M. (Labour Law) A university is a community of adults in which close personal relationships between adults can develop. These institutions of higher learning recognise the need for policies prohibiting sexual harassment but few have addressed the subtle issues surrounding consensual and special amorous relationships between academic staff members and students and whether they have the right to regulate private behaviour between adults. The aim of this minor dissertation is to explore th...

  5. Public science policy and administration. [cooperation of government industry, foundations, and educational institutions

    Science.gov (United States)

    Rosenthal, A. H. (Editor)

    1973-01-01

    Science, the overwhelming concern of our time, is no longer a matter of private research and development but one of public policy and administration, in which government, industry, foundations, and educational institutions must all work together as never before. Few other single tasks are of such decisive importance to the collective and individual welfare of American citizens as the formulation of public science policy and the administration of scientific programs. Eleven national authorities of varied background in science, education, and government administration contribute their experience and their judgment in an effort to deal with the major aspects of the subject. Their focus is on the meeting of actual problems; they consider the decision making process in both public and public-private organizations. Topics are grouped in three general categories: personnel needs and resources, organizational problems and techniques, and the administrative role in policy leadership.

  6. Integrated community case management in Malawi: an analysis of innovation and institutional characteristics for policy adoption.

    Science.gov (United States)

    Rodríguez, Daniela C; Banda, Hastings; Namakhoma, Ireen

    2015-12-01

    In 2007, Malawi became an early adopter of integrated community case management for childhood illnesses (iCCM), a policy aimed at community-level treatment for malaria, diarrhoea and pneumonia for children below 5 years. Through a retrospective case study, this article explores critical issues in implementation that arose during policy formulation through the lens of the innovation (i.e. iCCM) and of the institutions involved in the policy process. Data analysis is founded on a documentary review and 21 in-depth stakeholder interviews across institutions in Malawi. Findings indicate that the characteristics of iCCM made it a suitable policy to address persistent challenges in child mortality, namely that ill children were not interacting with health workers on a timely basis and consequently were dying in their communities. Further, iCCM was compatible with the Malawian health system due to the ability to build on an existing community health worker cadre of health surveillance assistants (HSAs) and previous experiences with treatment provision at the community level. In terms of institutions, the Ministry of Health (MoH) demonstrated leadership in the overall policy process despite early challenges of co-ordination within the MoH. WHO, United Nations Children's Fund (UNICEF) and implementing organizations played a supportive role in their position as knowledge brokers. Greater challenges were faced in the organizational capacity of the MoH. Regulatory issues around HSA training as well as concerns around supervision and overburdening of HSAs were discussed, though not fully addressed during policy development. Similarly, the financial sustainability of iCCM, including the mechanisms for channelling funding flows, also remains an unresolved issue. This analysis highlights the role of implementation questions during policy development. Despite several outstanding concerns, the compatibility between iCCM as a policy alternative and the local context laid the

  7. Developing the National Knowledge Platform in India: a policy and institutional analysis.

    Science.gov (United States)

    Sriram, Veena; Bennett, Sara; Raman, V R; Sheikh, Kabir

    2018-02-20

    The importance of strong engagement between researchers and decision-makers in the improvement of health systems is increasingly being recognised in low- and middle-income countries (LMICs). In 2013, in India, the Ministry of Health and Family Welfare began exploring the formation of a National Knowledge Platform (NKP) for guiding and supporting public health and health systems research in the country. The development of the NKP represents an important opportunity to enhance the linkage between policy-makers and researchers from the health policy and systems research field in India. However, the development process also reflects the highly complex reality of policy-making in the Indian health sector. Our objective is to provide insight into the policy-making process for establishing a health sector knowledge platform in India, and in doing so, to analyse the enabling contextual factors, the interests and actions of stakeholders, and the varying institutional arrangements explored in the development of the NKP. We used a qualitative case study methodology, conducting 16 in-depth interviews and reviewing 42 documents. We utilised General Thematic Analysis to analyse our data. Our research team combined perspectives from both outsiders (independent researchers with no prior or current involvement with the policy) and insiders (researchers involved in the policy-making process). We found that enabling contextual factors, and a combination of government and non-governmental stakeholders with core interests in public health and health systems, were able to gain considerable momentum in moving the idea for the NKP forward. However, complex evidence-to-policy processes in the Indian health sector resulted in complications in determining the right institutional arrangement for the platform. Establishing the appropriate balance between legitimacy and independence, as well as frequent changes in institutional leadership, were found to be additional issues that stakeholders

  8. Institutional policy changes aimed at addressing obesity among mental health clients.

    Science.gov (United States)

    Knol, Linda L; Pritchett, Kelly; Dunkin, Jeri

    2010-05-01

    People with mental illness often experience unique barriers to healthy eating and physical activity. For these clients, interventions should focus on changes in the immediate environment to change behaviors. The purpose of this project was to implement and evaluate policy changes that would limit calorie intake and increase calorie expenditure of clients receiving mental health services. This intervention was implemented in a rural mental health system in the southeastern United States. Clients live in small group homes, where they are served breakfast, dinner, and a snack, and attend outpatient day treatment programs, where they are served lunch and can purchase snacks from vending machines. This intervention included institutional policy changes that altered menus and vending machine options and implemented group walking programs. Primary outcome measures were changes in clients' weight at 3 and 6 months after policy implementation. At the 3-month follow-up, the median weight loss for overweight/obese clients (n = 45) was 1.4 kg. The 33 overweight/obese clients who were still in the group homes at the 6-month follow-up either maintained or continued to lose weight. Institutional policy changes aimed at improving dietary intake and physical activity levels among clients receiving mental health services can promote weight loss in overweight clients.

  9. Institutional stakeholder perceptions of barriers to addiction treatment under Mexico's drug policy reform.

    Science.gov (United States)

    Werb, Dan; Strathdee, Steffanie A; Meza, Emilo; Rangel Gomez, Maria Gudelia; Palinkas, Lawrence; Medina-Mora, Maria Elena; Beletsky, Leo

    2017-05-01

    Mexico has experienced disproportionate drug-related harms given its role as a production and transit zone for illegal drugs destined primarily for the USA. In response, in 2009, the Mexican federal government passed legislation mandating pre-arrest diversion of drug-dependent individuals towards addiction treatment. However, this federal law was not specific about how the scale-up of the addiction treatment sector was to be operationalised. We therefore conducted in-depth qualitative interviews with key 'interactors' in fields affected by the federal legislation, including participants from the law enforcement, public health, addiction treatment, and governmental administration sectors. Among 19 participants from the municipal, state and federal levels were interviewed and multiple barriers to policy reform were identified. First, there is a lack of institutional expertise to implement the reform. Second, the operationalisation of the reform was not accompanied by a coordinated action plan. Third, the law is an unfunded mandate. Institutional barriers are likely hampering the implementation of Mexico's policy reform. Addressing the concerns expressed by interactors through the scale-up of services, the provision of increased training and education programmes for stakeholders and a coordinated action plan to operationalise the policy reform are likely needed to improve the policy reform process.

  10. Application of the IPI Model to a Perceptual Development Curriculum.

    Science.gov (United States)

    Rosner, Jerome

    The Individually Prescribed Instruction (IPI) Model developed by Bolvin and Glaser (1968) is applied to a perceptual development curriculum for children manifesting learning disabilities. The Model utilizes criterion referenced tests for behavioral objectives in four areas: general motor, visual motor, auditory motor, and integrative. Eight units…

  11. A Plan for Evaluating the IPI Testing Program.

    Science.gov (United States)

    Unks, Nancy J.

    The testing sub-program is designed to provide the diagnostic instruments necessary to measure pupil progress through the Individually Prescribed Instruction (IPI) curricula. Its objectives are to provide information about pupils which teachers can use to direct each child's individual learning program, to provide the measurements necessary for…

  12. Topological px+ipy superfluid phase of fermionic polar molecules

    NARCIS (Netherlands)

    Levinsen, J.; Cooper, N.R.; Shlyapnikov, G.V.

    2011-01-01

    We discuss the topological px+ipy superfluid phase in a 2D gas of single-component fermionic polar molecules dressed by a circularly polarized microwave field. This phase emerges because the molecules may interact with each other via a potential Vo(r) that has an attractive dipole-dipole 1/r^3 tail,

  13. Transformation trend of the institution of family. Family as a value, expectations, family policy

    Directory of Open Access Journals (Sweden)

    Silinsh R.

    2016-01-01

    Full Text Available This paper is devoted to the transformation trend of the institution of family which has not been deeply studied yet, and no proper attention has been paid to modern changes that have such an essential influence on the future of the family and our future in general. That is why the main aim of the research is to find out, on the basis of statistics, what factors influenced the transformation trend of the institution of family, and led to a reassessment of family values, what role is played by the state in forming the family policy, what are the future prospects for the institution of family. The results of our survey showed that the demographic situation in both countries Ukraine and Latvia needs improvement and we made up our own plan how to do it; we found what influenced the transformation trend of the institution of family; what are the values of modern families and changes related to them; compared the family policies of both countries and found out that the traditional family is under threat of disappearance. Our research proves that family is one of the most important values, whose stability and success are a guarantee of social welfare.

  14. Publishing Activity of RAS Economic Institutes amid New Challenges of Science Policy

    Directory of Open Access Journals (Sweden)

    Tret’yakova Ol’ga Valentinovna

    2017-01-01

    Full Text Available New challenges of science policy in Russia have determined a number of objectives which require scientific institutions to implement specific solutions aimed at improving research quality and efficiency. Since the evaluation of research results requires the use of different metrics, including bibliometrics, the main issue lies in the choice of indicators which can be used to conduct multi-analysis. The aim of this study is to implement the holistic approach to bibliometric assessment of scientific institutions and to analyze the performance of academic activity of economic institutions on the basis of the proposed criteria. The article summarizes the results of scientometric indicators monitoring, conducted at the Institute of Socio-Economic Development of Territories of the Russian Academy of Sciences. The analysis is based on a large set of publications of academic economic institutions for the period 2011–2015. The informational basis of the research includes data of the Russian Science Citation Index (RSCI. The institutions were ranked by a number of criteria: total number of publications in the RSCI and journals from the VAK list of Publications, number of citations. The author analyses the h-index value dynamics and indicators characterizing the number of publications considered as most-cited for the reference group in question. Conclusions and data obtained during analysis may be useful for studying development trends of economic science in Russia and assessing the performance of scientific organizations based on researching the dynamics of individual publication indicators and their comparison by reference group

  15. Expansion planning of brazilian electric sector: institutional changes, new policies and new instruments for planning

    International Nuclear Information System (INIS)

    Bajay, S.V.; Silva, W.A. da; Ricciulli, D.L.S.

    1990-01-01

    The Brazilian power supply industry has been in crisis for many years, particularly due to financial and institutional problems. There are many reasons for that, several of them from outside the industry. In this paper a diagnosis of the main elements of this crisis is worked out, in the context of the industry's expansion planning. Following, institutional changes, new policies and new instruments are proposed for this planning. The institutional setting, the demand studies, the demand side management, the supply optimisation, the rural electrification, the decentralized generation of electricity, the tariff structure, the ways of financing the industry, the technological advances, the social and environmental impacts and the integrated planning of the industry are discussed, together with the planning of the power supply industry interactions with the other energy supply industries and the rest of the economy. (author)

  16. Challenges in Education Research in Taiwan: Research Institutes and Organizations, Research Policies, and Problems

    Directory of Open Access Journals (Sweden)

    Jia Li Huang

    2017-02-01

    Full Text Available Since the 1990s, many education researchers and policy makers worldwide have reviewed education research to attempt to provide strategies to improve the quality of such research in their countries. Taiwan’s government has launched policies and funded support to set the benchmark for Taiwan’s leading universities in international academic competition. The external environment of global competition based on research policy influences the ecosystem of social science research production. To assure the quality of education policy, peer review from within the education community is one approach to supplementing the government’s governance, including the establishment of research institutes, promotion, rewards, and research value. This study tracked the mode of academic research and provides an overview of the status of academic education research in Taiwan. Because education research is part of the humanities and social sciences fields, this study identified the challenges in educational research by examining the trend of social science research and by analyzing research organizations, policy, and the evaluation of research performance. Due to the environment of education research in Taiwan is not friendly to education researcher to accumulate papers in SSCI or international journal, additional concerns entail how education research communities can develop and agree on its quality.

  17. Recommendations for institutional policy and network regulatory frameworks towards distributed generation in EU Member States

    Energy Technology Data Exchange (ETDEWEB)

    Ten Donkelaar, M.; Van Oostvoorn, F. [ECN Policy Studies, Petten (Netherlands)

    2005-01-01

    Recommendations regarding the development of regulatory frameworks and institutional policies towards an optimal integration of distributed generation (DG) into electricity networks are presented. These recommendations are based on findings from a benchmarking study conducted in the framework of the ENIRDG-net project. The aim of the benchmarking exercise was to identify examples of well-defined pro-DG policies, with clear targets and adequate implementation mechanisms. In this study an adequate pro-DG policy is defined on the basis of a level playing field, a situation where distributed and centralised generation receive equal incentives and have equal access to the liberalised markets for electricity. The benchmark study includes the results of a similar study conducted in the framework of the SUSTELNET project. When comparing the results a certain discrepancy can be noticed between the actual regulation and policy in a number of countries, the medium to long-term targets and the ideal situation described by the level playing field objective. To overcome this discrepancy, a number of recommendations have been drafted for future policy and regulation towards distributed generation.

  18. Institutional Control Policies and Implementation for the Area 5 and Area 3 Radioactive Waste Management Sites

    Energy Technology Data Exchange (ETDEWEB)

    Vefa Yucel, Greg Shott, Denise Wieland, et al.

    2007-11-01

    The U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Site Office (NNSA/NSO) has implemented varying institutional control policies in performance assessment/composite analysis (PA/CA) calculations for the Area 5 and Area 3 Radioactive Waste Management Sites (RWMSs) (Shott et al., 1998; 2000; Bechtel Nevada [BN] and Neptune and Company Inc. [Neptune], 2006). The facilities are within the actively maintained boundaries of the Nevada Test Site (NTS) that are enforced by NNSA/NSO. Under current policies, access required for exposure of the member of public (MOP) or the inadvertent human intruder (IHI) is prohibited. Uncertainties affecting institutional control policies are the duration and effectiveness of the controls during the post-closure period. Implementing a uniform set of institutional control policies for the RWMSs that encompasses waste management and environmental restoration programs and is consistent with the end-state vision for the environmental management programs for the NTS (DOE, 2006) is a primary goal of the maintenance program. The NNSA/NSO Performance Management Plan (DOE, 2002) complies with DOE Policy P455.1, 'Use of Risk-Based End States' (DOE, 2003a). Expected future land uses are a driver in selecting acceptable end state conditions and clean-up goals for the NTS. NNSA/NSO Environmental Management's (EM's) land management assumptions and framework for Environmental Management activities are as follows: The NTS will remain under federal control in perpetuity as an NNSA test site, and the large buffer zone surrounding the NTS (the Nevada Test and Training Range) is assumed to remain under the control of the U.S. Air Force. There are no plans for transfer of any NTS lands to other agencies or public entities. Access will continue to be restricted to the NTS and the surrounding areas. For management purposes, NNSA/NV EM activities have been established based on the source of contamination and

  19. Institutional Control Policies and Implementation for the Area 5 and Area 3 Radioactive Waste Management Sites

    International Nuclear Information System (INIS)

    Vefa Yucel; Greg Shott; Denise Wieland

    2007-01-01

    The U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Site Office (NNSA/NSO) has implemented varying institutional control policies in performance assessment/composite analysis (PA/CA) calculations for the Area 5 and Area 3 Radioactive Waste Management Sites (RWMSs) (Shott et al., 1998; 2000; Bechtel Nevada [BN] and Neptune and Company Inc. [Neptune], 2006). The facilities are within the actively maintained boundaries of the Nevada Test Site (NTS) that are enforced by NNSA/NSO. Under current policies, access required for exposure of the member of public (MOP) or the inadvertent human intruder (IHI) is prohibited. Uncertainties affecting institutional control policies are the duration and effectiveness of the controls during the post-closure period. Implementing a uniform set of institutional control policies for the RWMSs that encompasses waste management and environmental restoration programs and is consistent with the end-state vision for the environmental management programs for the NTS (DOE, 2006) is a primary goal of the maintenance program. The NNSA/NSO Performance Management Plan (DOE, 2002) complies with DOE Policy P455.1, 'Use of Risk-Based End States' (DOE, 2003a). Expected future land uses are a driver in selecting acceptable end state conditions and clean-up goals for the NTS. NNSA/NSO Environmental Management's (EM's) land management assumptions and framework for Environmental Management activities are as follows: The NTS will remain under federal control in perpetuity as an NNSA test site, and the large buffer zone surrounding the NTS (the Nevada Test and Training Range) is assumed to remain under the control of the U.S. Air Force. There are no plans for transfer of any NTS lands to other agencies or public entities. Access will continue to be restricted to the NTS and the surrounding areas. For management purposes, NNSA/NV EM activities have been established based on the source of contamination and type of waste

  20. Patient-centred outcomes research: brave new world meets old institutional policies.

    Science.gov (United States)

    Chung, Jessica S; Young, Henry N; Moreno, Megan A; Kliems, Harald; Cox, Elizabeth D

    2017-06-01

    Engaging patients across the research trajectory supports research that is generalizable, high quality, timely and actionable. However, this approach comes with challenges and opportunities as investigators and engaged patient stakeholders encounter institutional policies around patient engagement, privacy and research participant protection. To describe the resolution and impact of quandaries arising when patient stakeholders' values and preferences conflicted with institutional policies. Case study from a Patient-Centered Outcomes Research Institute-funded trial. The first example focuses on the tension between the health care organization's requirements for background checks for all patient advisors and the funders' requirement to engage hard-to-reach populations. To create an environment of mutual trust and respect with patient stakeholders, the research team decided against imposing background checks. All 53 patient and parent advisors have served continuously for 2 years and meeting attendance exceeds 95%. The second example describes parent stakeholders' role in revising a letter informing patients about a privacy violation. Among 49 families affected by and informed about this violation, 35 (71%) agreed to participate. The third example focuses on how patient stakeholder preferences about study reminders conflict with the 1996 Health Insurance Portability and Accountability Act rules. While patient stakeholders strongly endorsed text message reminders, regulations and technology do not permit reminders with enough detail to ensure clarity. Although retention rates exceeded 90%, attendance at study appointments was below 75% and below 60% for minority and low socio-economic status families. Patient engagement positively impacts research. Resolving conflicts between patient-engaged research and existing institutional policies and regulations would allow this impact to become fully realized. © The Author 2017. Published by Oxford University Press. All rights

  1. Greenhouse policy studies by ECON and the Fridtjof Nansen Institute. 13 abstracts

    International Nuclear Information System (INIS)

    Roland, Kjell; Sydnes, Anne Kristin

    1991-01-01

    The main focus of the programme is the relationship between energy, environment and development in the Third World and international co-operation in relation to global climate change. A series of working papers and reports will primarily review and analyse energy strategies in developing countries and the political, institutional and economic factors which have an impact on current and future energy supply and demand. Energy market structures and energy policies of selected countries will be studies in light of global environmental problems and the recommendations from the World Commission on Environment and Development. Attention will be given to North/South conflicts in relation to the challenge of global climate change. Institutional and financial mechanisms to promote transfer of resources to developing countries will be discussed. EED is a professionally independent research programme, financially supported by the Norwegian Research Council for Applied Social Science (NORAS), the Ministry of Foreign Affairs, the Ministry of Environment and Statoil. The project titles are: 1) The North/South dimension in global greenhouse policies. Conflicts, dilemma, solutions. 2) Energy - a growth limiting factor. 3) Environment, security and politicians., Do they really mean (and know) what they are saying. 4) The Soviet Union and climatic changes: Heading for the eternal summer. 5) EC greenhouse policy. 6) Brazilian energy policy. Self-sufficiency and states intervention. 7) Mexico - a country in economic and ecological crisis. 8) Energy, environment and development in China. 9) Energy, environment and economic growth in a developing country perspective. 10) Stabilising CO 2 emissions by carbon taxes- a viable option. 11) Developing countries in global climate negotiations. 12) US greenhouse policy: Reactionary or realistic. 13) Effective verification of international greenhouse agreements: Technically feasible, but politically complicated. Report abstracts are included in

  2. Greenhouse policy studies by ECON and the Fridtjof Nansen Institute. 13 abstracts

    Energy Technology Data Exchange (ETDEWEB)

    Roland, Kjell; Sydnes, Anne Kristin

    1991-07-01

    The main focus of the programme is the relationship between energy, environment and development in the Third World and international co-operation in relation to global climate change. A series of working papers and reports will primarily review and analyse energy strategies in developing countries and the political, institutional and economic factors which have an impact on current and future energy supply and demand. Energy market structures and energy policies of selected countries will be studies in light of global environmental problems and the recommendations from the World Commission on Environment and Development. Attention will be given to North/South conflicts in relation to the challenge of global climate change. Institutional and financial mechanisms to promote transfer of resources to developing countries will be discussed. EED is a professionally independent research programme, financially supported by the Norwegian Research Council for Applied Social Science (NORAS), the Ministry of Foreign Affairs, the Ministry of Environment and Statoil. The project titles are: 1) The North/South dimension in global greenhouse policies. Conflicts, dilemma, solutions. 2) Energy - a growth limiting factor. 3) Environment, security and politicians., Do they really mean (and know) what they are saying. 4) The Soviet Union and climatic changes: Heading for the eternal summer. 5) EC greenhouse policy. 6) Brazilian energy policy. Self-sufficiency and states intervention. 7) Mexico - a country in economic and ecological crisis. 8) Energy, environment and development in China. 9) Energy, environment and economic growth in a developing country perspective. 10) Stabilising CO{sub 2} emissions by carbon taxes- a viable option. 11) Developing countries in global climate negotiations. 12) US greenhouse policy: Reactionary or realistic. 13) Effective verification of international greenhouse agreements: Technically feasible, but politically complicated. Report abstracts are

  3. South Africa's rapid electrification programme: Policy, institutional, planning, financing and technical innovations

    Energy Technology Data Exchange (ETDEWEB)

    Bekker, Bernard [Department of Electrical Engineering, Faculty of Engineering and The Built Environment, University of Cape Town, Private Bag X3, RONDEBOSCH 7700 (South Africa); Eberhard, Anton [Graduate School of Business, University of Cape Town, Cape Town (South Africa); Gaunt, Trevor [Electrical Engineering Department, University of Cape Town, Cape Town (South Africa); Marquard, Andrew [Energy Research Centre, University of Cape Town, Cape Town (South Africa)

    2008-08-15

    This paper documents South Africa's electrification programme from the late 1980s to the present. The primary aim of the paper is to present the reader with an overview of the policy, institutional, planning, financing and technological developments and innovations that resulted in more than 5 million households receiving access to electricity between 1990 and 2007. Key aspects include the way in which a period of political change and policy disruption were essential to the programme's initiation, and the critical role played by organisations and individuals outside of national government in helping shape new electrification policies and strategies. In addition, the paper identifies the contribution of technology development in cost reduction and achieving the social aims of the programme. Several lessons may be drawn from the institutional and planning arrangements that the South African programme has developed, the significance of the development of appropriate cost-driven technical innovations and standards, and the acknowledgement of the social function of electrification and its funding from the fiscus (rather than through cross-subsidies). (author)

  4. Does Integrated Water Resources Management Support Institutional Change? The Case of Water Policy Reform in Israel

    Directory of Open Access Journals (Sweden)

    Itay Fischhendler

    2010-03-01

    Full Text Available Many international efforts have been made to encourage integrated water resources management through recommendations from both the academic and the aid and development sectors. Recently, it has been argued that integrated water resources management can help foster better adaptation of management and policy responses to emerging water crises. Nevertheless, few empirical studies have assessed how this type of management works in practice and what an integrated water management system implies for institutional adaptation and change. Our assessment of the Israeli water sector provides one view of how they can be shaped by an integrated structure in the water sector. Our analysis of recent efforts to adapt Israel's water management system to new conditions and uncertainties reveals that the interconnectedness of the system and the consensus decision-making process, led by a dominant actor who coordinates and sets the policy agenda, tends to increase the complexity of negotiations. In addition, the physical integration of water management leads to sunk costs of large-scale physical infrastructure. Both these factors create a path dependency that empowers players who receive benefits from maintaining the existing system. This impedes institutional reform of the water management system and suggests that integrated water resources management creates policy and management continuity that may only be amenable to incremental changes. In contrast, real adaptation that requires reversibility and the ability to change management strategies in response to new information or monitoring of specific management outcomes.

  5. Statement at Lowy Institute for International Policy, 4 October 2012, Sydney, Australia

    International Nuclear Information System (INIS)

    Amano, Y.

    2012-01-01

    It is a great pleasure for me to address this distinguished audience. The Lowy Institute for International Policy has established itself in less than a decade as a major contributor to serious thinking on foreign policy. Coming, as I do, from Japan, I welcome your focus on issues that particularly affect the Asia-Pacific region. This region sometimes has a different perspective on global affairs from Europe and North America. The research programmes and events organized by the Institute help to focus fresh thinking on issues critical to this region, and indeed to the whole world. The International Atomic Energy Agency has been around quite a bit longer than the Lowy Institute - 55 years, in fact. I suppose that makes us middle-aged. But I can assure you that the Agency has lost none of its youthful vigour when it comes to tackling the challenging mandate entrusted to us by our 155 Member States. Our mission is manifold, but can be summarised very simply. We help to make nuclear science and technology available to all countries for peaceful purposes - especially to countries in the developing world. And we work to prevent the spread of nuclear weapons

  6. Political and Institutional Drivers of Social Security Policy in South Africa

    DEFF Research Database (Denmark)

    S. Ulriksen, Marianne; Plagerson, Sophie

    This paper provides an analysis of political and institutional drivers that shape social policy in South Africa with a specific focus on social security. As elsewhere in the Global South, South Africa has a quite extensive social assistance framework, whereas social insurance is limited and inade......This paper provides an analysis of political and institutional drivers that shape social policy in South Africa with a specific focus on social security. As elsewhere in the Global South, South Africa has a quite extensive social assistance framework, whereas social insurance is limited...... arrangements, positive research evidence and civil society advocacy and litigation. Moreover, the introduction of a health insurance scheme is relatively more complex (politically, institutionally and technically), compared to expanding an already existing social cash transfer programme. In our analysis, we...... of health insurance, ideological narratives are pitted against each other: the concept of health as a common good against health as a commodity, and market-oriented strategies for delivery against state-centric approaches....

  7. Sites of institutional racism in public health policy making in New Zealand.

    Science.gov (United States)

    Came, Heather

    2014-04-01

    Although New Zealanders have historically prided ourselves on being a country where everyone has a 'fair go', the systemic and longstanding existence of health inequities between Māori and non-Māori suggests something isn't working. This paper informed by critical race theory, asks the reader to consider the counter narrative viewpoints of Māori health leaders; that suggest institutional racism has permeated public health policy making in New Zealand and is a contributor to health inequities alongside colonisation and uneven access to the determinants of health. Using a mixed methods approach and critical anti-racism scholarship this paper identifies five specific sites of institutional racism. These sites are: majoritarian decision making, the misuse of evidence, deficiencies in both cultural competencies and consultation processes and the impact of Crown filters. These findings suggest the failure of quality assurance systems, existing anti-racism initiatives and health sector leadership to detect and eliminate racism. The author calls for institutional racism to be urgently addressed within New Zealand and this paper serves as a reminder to policy makers operating within other colonial contexts to be vigilant for such racism. Copyright © 2014 Elsevier Ltd. All rights reserved.

  8. U.S. International Agricultural Trade Policy: Interests, Institutions and Information in the Corn Supply Chain

    Directory of Open Access Journals (Sweden)

    Laís Forti Thomaz

    2016-04-01

    Full Text Available The purpose of this article is to analyze the U.S. international agricultural trade policy by focusing on instruments and institutional arrangements. Policy decision-making is analyzed by means of three variables: 1 how interests are mobilized; 2 how information is disseminated; and 3 how spaces are occupied in deliberation arenas. The study refers to the corn sector and observes how the National Corn Growers Association operated to ensure subsidies and incentives for this supply chain along the elaboration of the 2002 and 2008 Farm Bills, as well as from other laws pertaining to agricultural and energy incentives. This paper provides evidences in favor of four arguments: first, empirical studies on the formulation and implementation of foreign trade policy, especially when it comes to agricultural issues, would greatly benefit with a greater attention on understanding the role domestic actors play in the decision-making processes; second, interest groups play a key role in this decision-making process; third, they provide the rationale for the formulation and implementation of the U.S. international agricultural trade policy; and, fourth, when the economic sector coordinates complex and relevant supply chains in the U.S. economy, it is hardly possible to revert the U.S. protectionist position in the Legislative branch.

  9. Information security in academic libraries: the role of the librarian in planning and introducing institutional policies

    Directory of Open Access Journals (Sweden)

    Juliana Soares Lima

    2017-04-01

    Full Text Available This study presents a short discussion about the role of the librarian as a mediator at planning, developing and implementing an Information Security Policy in Academic Libraries, by working together with professionals in the field of Information Technology. It also discusses the main virtual threats and some risks that are prone to infect computers in libraries. Based on the current legislation and on some normative documents about information security, it is confirmed the importance of the librarian take part in the main decision-making related to information security, such as planning a consistent Information Security Policy which be able to see the specific needs of Academic Libraries as institutions prone to cyberattacks. The main topics and guidelines to carry out an Information Security Policy are presented based on the results that were obtained through an action research, by visiting libraries to fill in application forms and to compose reports whose content was analyzed. Finally, the study concludes that Information Security Policy must be validated by managers of sectors or departments which the Academic Library is hierarchically subordinate to.

  10. [Effectiveness of institutional policies to prevent adolescent alcohol use: The view of experts and adolescents].

    Science.gov (United States)

    Suárez, Cristian; del Moral, Gonzalo; Musitu, Gonzalo; Sánchez, Juan Carlos; John, Bev

    2014-01-01

    The objective of this study is to obtain the views of a sample of adolescents and experts on adolescence, family, school, local policies and media, regarding the effectiveness of institutional policies to prevent adolescent alcohol use. Four educational centers in the province of Seville. Head office of the Alcohol and Society Foundation in Madrid. Qualitative study using the method proposed by Grounded theory (Glaser and Strauss, 1967). Data were collected from 10 discussion groups guided by semistructured interviews. The data were analyzed using Atlas ti 5 software. A total of 32 national experts and 40 adolescents of both sexes aged 15 to 20 years living in the province of Seville, selected by theoretical intentional sampling. The experts believed that most of the evaluated preventive actions were effective, while adolescents disputed the preventive impact of most of them. Adolescents proposed actions focused on the reduction of supply of alcohol. Experts proposed a mixed model as the most effective strategy to prevent alcohol consumption in adolescents, combining supply and demand reduction policies, depending on specific short and long term objectives. We have obtained, not only an overview of what is working (or not) from the view of adolescents and experts, but also the key points that should be taken into account for designing effective prevention policies. Copyright © 2013 Elsevier España, S.L.U. All rights reserved.

  11. Providing affordable essential medicines to African households: the missing policies and institutions for price containment.

    Science.gov (United States)

    Tetteh, Ebenezer kwabena

    2008-02-01

    Medicines are integral of any healthcare system, and limited access to medicines undermines health systems' objectives of equity, efficiency and health development. In African countries, where it is estimated that 50-60% of the populace lack "access" to essential medicines, health problems associated with limited drug benefits are more damaging. However, there is no single solution to medicine access problem given its multiple dimensions: availability, acceptability, affordability and accessibility. This paper explores affordability dimension of medicine access and concentrates solely on price regulatory policies and institutional structures that national and international policy makers may consider in making prices of essential drugs compatible to the purchasing power of African households. The main theme is the application of the concept of bilateral dependence in creating price-sensitive purchasers to exert countervailing market power on drug price setting in African healthcare systems.

  12. Regulatory, institutional, and market-based approaches towards achieving comprehensive chemical policy reform.

    Science.gov (United States)

    Welker-Hood, Kristen; Condon, Marian; Wilburn, Susan

    2007-05-31

    The purpose of this article is to inform nurses and other health care professionals about the nexus between the environment and health and present approaches in which they can be involved so as to support comprehensive reform of chemicals management in the United States. It discusses the health impact of hazardous chemicals and the environmental regulatory failures within the U.S. to protect the public. It also reports on international chemical management initiatives and key elements of chemical policy reform that can guide the U.S. regulatory, market-based, and institutional-based approaches to a comprehensive, chemical policy reform. The role of nursing in advocating for these reforms will be presented.

  13. ANDRILL Education and Public Outreach: A Legacy of the IPY

    Science.gov (United States)

    Rack, F. R.; Huffman, L. T.; Reed, J.; Harwood, D. M.; Berg, M.; Diamond, J.; Fox, A.; Dahlman, L. E.; Levy, R. H.

    2009-12-01

    ANDRILL field projects during the IPY included the McMurdo Ice Shelf (MIS) and Southern McMurdo Sound (SMS) drilling projects, and the Mackay Sea Valley (MSV) and Offshore New Harbor (ONH) seismic surveys. ANDRILL's international network of scientists, engineers, students and educators work together to convey an understanding of geoscience research and the process of science to non-technical audiences. ANDRILL education and public outreach (EPO) program goals are to: (1) promote environmental and polar science literacy for all audiences; (2) develop and disseminate engaging resources for formal and informal education; (3) develop and nurture a network of polar science educators; (4) spark the curiosity of students and the general public; (5) encourage students to pursue careers in science; (6) challenge misconceptions about scientific research; (7) provide professional development opportunities for educators; and, (8) encourage inquiry teaching in science education. During the IPY, ANDRILL established partnerships with several IPY projects to enhance science literacy and promote the IPY in formal and informal education and outreach venues. ANDRILL-led initiatives include the ARISE (ANDRILL Research Immersion for Science Educators) Program, Project Iceberg, the FLEXHIBIT (FLEXible exHIBIT; in partnership with Antarctica’s Climate Secrets/IPY Engaging Antarctica), and the Project Circle. ANDRILL partnerships developed with several museums and school districts for teacher professional development workshops and a variety of public events. A polar learning community was created from the ARISE participants and their many contacts, the Project Circle participants, and interested educators who contacted ANDRILL. EPO activities are continuing in the post-IPY period with additional funding. The ARISE program has been successful in building a team of educators and a network of international collaborations across grade levels and cultures. The ANDRILL website has expanded to

  14. New institutional mechanisms to bridge the information gap between climate science and public policy decisions

    Science.gov (United States)

    Rogers, W.; Gulledge, J. M.

    2010-12-01

    Many decision makers lack actionable scientific information needed to prepare for future challenges associated with climate change. Although the scope and quality of available scientific information has increased dramatically in recent years, this information does not always reach - or is not presented in a form that is useful to - decision makers who need it. The producer (i.e. scientists) community tends to be stovepiped, even though consumers (i.e. decision makers) often need interdisciplinary science and analysis. Consumers, who may also be stovepiped in various agencies or subject areas, may lack familiarity with or access to these separate communities, as well as the tools or time to navigate scientific information and disciplines. Closing the communication gap between these communities could be facilitated by institutionalizing processes designed for this purpose. We recommend a variety of mainstreaming policies within the consumer community, as well as mechanisms to generate a strong demand signal that will resonate more strongly with the producer community. We also recommend institutional reforms and methods of incentivizing policy-oriented scientific analysis within the producer community. Our recommendations focus on improving information flow to national security and foreign policy decision makers, but many are relevant to public policy writ large. Recommendations for Producers 1. The scientific community should formally encourage collaborations between natural and social scientists and reward publications in interdisciplinary outlets Incentives could include research funding and honorary awards recognizing service to public policy. 2. Academic merit review should reward research grants and publications targeted at interdisciplinary and/or policy-oriented audiences. Reforms of merit review may require new policies and engaged institutional leadership. Recommendations for Consumers 1. Congress should amend Title VI of the National Defense Education Act

  15. Introduction of a New National Currency; Policy, Institutional, and Technical Issues

    OpenAIRE

    Hernán Cortés Douglas; Richard K. Abrams

    1993-01-01

    In the last few years, a number of countries in the Former Soviet Union and Eastern Europe have become independent or regained their independence. Many have chosen to issue their own currencies and more are likely to do so. This paper draws on these and earlier experiences in order to summarize the main policy and institutional arrangements necessary for the introduction of a new currency and to discuss the key features of, and procedures for, the conversion. The paper is designed as a workin...

  16. NATO Advanced Research Institute on the Application of Systems Science to Energy Policy Planning

    CERN Document Server

    Cherniavsky, E; Laughton, M; Ruff, L

    1981-01-01

    The Advanced Research Institute (ARI) on "The Application of Systems Science to Energy Policy Planning" was held under the auspices of the NATO Special Programme Panel on Systems Science in collaboration with the National Center for Analysis of Energy Sys­ tems, Brookhaven National Laboratory, USA, as a part of the NATO Science Committee's continuous effort to promote the advancement of science through international cooperation. Advanced Research Institutes are sponsored by the NATO Science Committee for the purposes of bringing together senior scientists to seek consensus on an assessment of the present state of knowl­ edge on a specific topic and to make recommendations for future research directions. Meetings are structured to encourage inten­ sive group discussion. Invitees are carefully selected so that the group as a whole will contain the experience and expertise neces­ sary to make the conclusions valid and significant. A final report is published presenting the various viewpoints and conclusions....

  17. Validation of the NCCN-IPI for diffuse large B-cell lymphoma (DLBCL): the addition of β2-microglobulin yields a more accurate GELTAMO-IPI.

    Science.gov (United States)

    Montalbán, Carlos; Díaz-López, Antonio; Dlouhy, Ivan; Rovira, Jordina; Lopez-Guillermo, Armando; Alonso, Sara; Martín, Alejandro; Sancho, Juan M; García, Olga; Sánchez, Jose M; Rodríguez, Mario; Novelli, Silvana; Salar, Antonio; Gutiérrez, Antonio; Rodríguez-Salazar, Maria J; Bastos, Mariana; Domínguez, Juan F; Fernández, Rubén; Gonzalez de Villambrosia, Sonia; Queizan, José A; Córdoba, Raul; de Oña, Raquel; López-Hernandez, Andrés; Freue, Julian M; Garrote, Heidys; López, Lourdes; Martin-Moreno, Ana M; Rodriguez, Jose; Abraira, Víctor; García, Juan F

    2017-03-01

    The study included 1848 diffuse large B-cell lymphoma (DLBCL)patients treated with chemotherapy/rituximab. The aims were to validate the National Comprehensive Cancer Network International Prognostic Index (NCCN-IPI) and explore the effect of adding high Beta-2 microglobulin (β2M), primary extranodal presentation and intense treatment to the NCCN-IPI variables in order to develop an improved index. Comparing survival curves, NCCN-IPI discriminated better than IPI, separating four risk groups with 5-year overall survival rates of 93%, 83%, 67% and 49%, but failing to identify a true high-risk population. For the second aim the series was split into training and validation cohorts: in the former the multivariate model identified age, lactate dehydrogenase, Eastern Cooperative Oncology Group performance status, Stage III-IV, and β2M as independently significant, whereas the NCCN-IPI-selected extranodal sites, primary extranodal presentation and intense treatments were not. These results were confirmed in the validation cohort. The Grupo Español de Linfomas/Trasplante de Médula ósea (GELTAMO)-IPI developed here, with 7 points, significantly separated four risk groups (0, 1-3, 4 or ≥5 points) with 11%, 58%, 17% and 14% of patients, and 5-year overall survival rates of 93%, 79%, 66% and 39%, respectively. In the comparison GELTAMO IPI discriminated better than the NCCN-IPI. In conclusion, GELTAMO-IPI is more accurate than the NCCN-IPI and has statistical and practical advantages in that the better discrimination identifies an authentic high-risk group and is not influenced by primary extranodal presentation or treatments of different intensity. © 2017 John Wiley & Sons Ltd.

  18. An introduction to the HighARCS Integrated Action Plans, with an institutions, policies and conflicts perspective

    DEFF Research Database (Denmark)

    Lund, Søren

    This report is an introduction focused on institutions, policies and conflicts aspects, for the Integrated Action Plans (IAPs) produced by the HighARCS project for the 5 sites in China, India and Vietnam......This report is an introduction focused on institutions, policies and conflicts aspects, for the Integrated Action Plans (IAPs) produced by the HighARCS project for the 5 sites in China, India and Vietnam...

  19. Seeing It through: Advanced Strategies "for" Influencing Education Policy. Education Grantmakers Institute (Cambridge, Massachusetts, May 19-21, 2009)

    Science.gov (United States)

    Mackinnon, Anne

    2009-01-01

    "No education grantmaker can afford to ignore public policy. Local, state and federal policies shape the context in which we work by establishing education standards, allocating resources and setting priorities for people working in education." So begins the report on Grantmakers for Educations' 2005 Grantmakers Institute, Foundation…

  20. 78 FR 54677 - Trade, Investment, and Industrial Policies in India: Effects on the U.S. Economy; Institution of...

    Science.gov (United States)

    2013-09-05

    ... measures on U.S. firms that export to or invest in India, or that have not done so because of the measures... Policies in India: Effects on the U.S. Economy; Institution of Investigation and Scheduling of Hearing... investigation No. 332-543, Trade, Investment, and Industrial Policies in India: Effects on the U.S. Economy...

  1. Targeting women or transforming institutions? Policy lessons from NGO anti-poverty efforts.

    Science.gov (United States)

    Kabeer, N

    1995-05-01

    Some research has found that the extent of gender-based discrimination in market-based institutions and unfair advantages within domestic and market institutions meant women were less successful in translating education and work into income and purchasing power. Anti-poverty programs functioned without specifically addressing the implications for women and children. Women-in-development efforts attempted to compensate for prior deficiencies by promotion of income generation schemes for women. In this article, the suggestion is made for policy makers to design projects with goals, objectives, and strategies that are clear, consistent, and well-informed about gender. Efforts should be made to avoid debates about women-only versus integrated projects. The experiences of nongovernmental organizations (NGOs) in the South Asian context offer lessons in good policy efforts to address all forms of marginalization. The definition of women's needs must be provided by women themselves; openness and flexibility are recommended. Participatory approaches serve the aims of needs identification, involvement in democratic processes, and awareness of constraints on women's use of resources. In credit lending, constraints were overcome by compensating for the absence of material collateral, guaranteeing physical access, simplifying procedures, and subsidizing access rather than interest rates. Underlying structural conditions that reinforce inequalities by gender are in need of change. Empowerment of women would assure that marginalization would not occur.

  2. [Inclusive education policy: perceptions of managers about the process of changes in Higher Education Institutions].

    Science.gov (United States)

    Pereira, Francilene Jane Rodrigues; dos Santos, Sérgio Ribeiro; da Silva, Cesar Cavalcanti

    2011-01-01

    This is a qualitative descriptive exploratory study, conducted in Higher Education Institutions (HEI) which offers Nursing course, in Joao Pessoa-PB. The study aimed to understand the concept of managers about the need for organizational changes to attend customers with special needs. Four managers participated in the study. A semi-structured interview with guiding questions was used to collect information and to interpret the data we used the method of discourse analysis based on Fiorin. It was noticed that the managers have a concern to meet the demands of inclusive policies, including the adequacy of physical spaces and the pedagogy adopted to meet the students' needs. However, some of them admitted to have little knowledge on how to deal with students with special needs and also mentioned that the institutions do not have an efficient and logistic work which can meet the current legislation of inclusion. We concluded that the process of structural and pedagogical changes is built in a slow and gradual way and it requires an involvement of qualified managers who are committed to execute the policies of inclusion of customers with special needs in a civil and legal way.

  3. National University Extension Policy: analysis of the experience of the Institute of Health Sciences of UFPA

    Directory of Open Access Journals (Sweden)

    Durbens Martins Nascimento

    2017-11-01

    Full Text Available The current study purpose refers to the university extension, addressing the concepts of university, organization, knowledge andextension. We sought to answer the following question: Does the outcome that has been generated through projects on extension practices developed by ICS/UFPA actually fulfill the guidelines of the National University Extension Policy? The pursued objective consisted in a general analysisof the extension practices of the Institute of Health Sciences (ICS at the Federal University of Pará (UFPA in the light of the National University Extension Policy (NUEP, comprehending dialogical interaction, interdisciplinary and interprofessionalism, teaching-research-extension inseparability, impact on student training, and impact and social transformation envisaged within the Policy Extension of UFPA. The research methodology comprehended a quantitative and qualitative approach supported by bibliographic and documentary supply. It was consulted the collection of various documents, given more evidence to those focused on the university extension in 2012, contained into several instances of UFPA. A number of 80 projects and 60 reports of extension of ICS were selected for analysis in the year 2012. The results revealed that the guidelines of PNEU fell far short of being reached by the ICS products, when it came to interdisciplinarity and interprofessionalism, teaching-research-extension inseparability, and impact and social transformation. Furthermore, there was little participation by teachers, students and administrative technicians of ICS in such activity. It was concluded that the extension model of ICS consists is a welfare model, developed through service provision.

  4. IPA-IPY Thermal State of Permafrost (TSP) Snapshot Borehole Inventory, Version 1

    Data.gov (United States)

    National Aeronautics and Space Administration — During the planning and implementation of the International Polar Year (IPY) 2007 - 2009, the International Permafrost Association (IPA) coordinated the acquisition...

  5. Effects of EU harmonization policies on national public supervision of clinical trials: A dynamic cycle of institutional change and institutional work.

    Science.gov (United States)

    van Oijen, Jacqueline C F; Grit, Kor J; van de Bovenkamp, Hester M; Bal, Roland A

    2017-09-01

    The EU Clinical Trials Directive (EUCTD) and the EU Clinical Trials Regulation aim to harmonize good clinical practice (GCP) of clinical trials across Member States. Using the Netherlands as a case study, this paper analyzes how endeavours to implement the EUCTD set in motion a dynamic process of institutional change and institutional work. This process lead to substantial differences between policy and actual practice; therefore, it is important to learn more about the implementation of harmonization policies. Relevant documents, such as legal texts and previous research, were analyzed. Interviews were conducted with stakeholders in clinical trials and inspectors from (inter)national supervisory bodies (n=33), and Dutch Health Care Inspectorate inspections were observed (n=4). Dutch legislators' efforts to implement the EUCTD created a new level of governance in an already multilevel legislative framework. Institutional layering caused a complex and fragmented organizational structure in public supervision, leading to difficulties in achieving GCP. This instigated institutional work by actors, which set in motion further incremental institutional change, principally drift and conversion. Harmonization processes can create dynamic cycles between institutional change and institutional work, leading to significant divergence from the intended effects of legislation. If legislation intended to strengthen harmonization is not carefully implemented, it can become counterproductive to its aims. Copyright © 2017 Elsevier B.V. All rights reserved.

  6. The Role of Policy Makers and Institutions in the Energy Sector: The Case of Energy Infrastructure Governance in Nigeria

    Directory of Open Access Journals (Sweden)

    Norbert Edomah

    2016-08-01

    Full Text Available This paper focuses on investigating the linkages and consequences of the policy decision process in the governance of energy infrastructure in Nigeria. It attempts to gain a better understanding of the role of policy makers and institutions in the provision of energy infrastructure in Nigeria. Using a combination of semi-structured interviews and documentary evidences from published literature, this study reveals three essential areas where the policy-making processes (and therefore policy makers intervene in the provision of energy infrastructure. These are: (1 granting access to historical data; (2 regulations; and (3 permitting/issuance of licenses. This study also reveals three major unintended consequences of the policy decision processes and institutions in the governance of energy infrastructure provisions in Nigeria, which are: (1 government financing corruption in the energy sector; (2 economic delusion; and (3 uncontrolled growth in energy demand driven more by export and not local internal demand.

  7. Why Public Comments Matter: The Case of the National Institutes of Health Policy on Single Institutional Review Board Review of Multicenter Studies.

    Science.gov (United States)

    Ervin, Ann-Margret; Taylor, Holly A; Ehrhardt, Stephan; Meinert, Curtis L

    2018-03-06

    In 2014, the National Institutes of Health (NIH) requested public comments on a draft policy requiring NIH-funded, U.S.-based investigators to use a single institutional review board (sIRB) for ethical review of multicenter studies. The authors conducted a directed content analysis and qualitative summary of the comments and discuss how they shaped the final policy. Two reviewers independently assessed support for the policy from a review of comments responding to the draft policy in 2016. A reviewer conducted an open text review to identify prespecified and additional comment themes. A second researcher reviewed 20% of the comments; discrepancies were resolved through discussion. The NIH received 167 comments: 65% (108/167) supportive of the policy, 23% (38/167) not supportive, and 12% (21/167) not indicating support. Clarifications or changes to the policy were suggested in 102/167 comments (61%). Criteria for selecting sIRBs were addressed in 32/102 comments (31%). Also addressed were IRB responsibilities (39/102; 38%), cost (27/102; 26%), the role of local IRBs (14/102; 14%), and allowable policy exceptions (19/102; 19%). The NIH further clarified or provided additional guidance for selection criteria, IRB responsibilities, and cost in the final policy (June 2016). Local IRB reviews and exemptions guidance were unchanged. In this case study, public comments were effective in shaping policy as the NIH modified provisions or planned supplemental guidance in response to comments. Yet critical knowledge gaps remain and empirical data are necessary. The NIH is considering mechanisms to support the establishment of best practices for sIRB implementation.

  8. Ensuring due process in the IACUC and animal welfare setting: considerations in developing noncompliance policies and procedures for institutional animal care and use committees and institutional officials.

    Science.gov (United States)

    Hansen, Barbara C; Gografe, Sylvia; Pritt, Stacy; Jen, Kai-Lin Catherine; McWhirter, Camille A; Barman, Susan M; Comuzzie, Anthony; Greene, Molly; McNulty, Justin A; Michele, Daniel Eugene; Moaddab, Naz; Nelson, Randall J; Norris, Karen; Uray, Karen D; Banks, Ron; Westlund, Karin N; Yates, Bill J; Silverman, Jerald; Hansen, Kenneth D; Redman, Barbara

    2017-10-01

    Every institution that is involved in research with animals is expected to have in place policies and procedures for the management of allegations of noncompliance with the Animal Welfare Act and the U.S. Public Health Service Policy on the Humane Care and Use of Laboratory Animals. We present here a model set of recommendations for institutional animal care and use committees and institutional officials to ensure appropriate consideration of allegations of noncompliance with federal Animal Welfare Act regulations that carry a significant risk or specific threat to animal welfare. This guidance has 3 overarching aims: 1 ) protecting the welfare of research animals; 2 ) according fair treatment and due process to an individual accused of noncompliance; and 3 ) ensuring compliance with federal regulations. Through this guidance, the present work seeks to advance the cause of scientific integrity, animal welfare, and the public trust while recognizing and supporting the critical importance of animal research for the betterment of the health of both humans and animals.-Hansen, B. C., Gografe, S., Pritt, S., Jen, K.-L. C., McWhirter, C. A., Barman, S. M., Comuzzie, A., Greene, M., McNulty, J. A., Michele, D. E., Moaddab, N., Nelson, R. J., Norris, K., Uray, K. D., Banks, R., Westlund, K. N., Yates, B. J., Silverman, J., Hansen, K. D., Redman, B. Ensuring due process in the IACUC and animal welfare setting: considerations in developing noncompliance policies and procedures for institutional animal care and use committees and institutional officials. © FASEB.

  9. Response to Environmental Policy Institute report on Savannah River Plant high-level waste management

    International Nuclear Information System (INIS)

    1986-01-01

    In a recently published report entitled ''Deadly Crop in the Tank Farm,'' the Environmental Policy Institute (EPI) presented its opinions on the hazards associated with waste management practices at SRP. The EPI's allegations were based on selected published Department of Energy and Du Pont reports and on raw data from the unpublished 200-Area Fault Tree Data Bank that it obtained in 1983. Professional staff at SRP have reviewed the report in detail and have provided responses in this document to all significant EPI statements and recommendations. The responses are grouped into five major categories: Waste Management Operations -- Past and Present, Accidents and Risks, Worker Exposure and Cancer Epidemiology, Groundwater Contamination, and Long-Term Waste Management. An overview of the responses is provided in the Summary, and the detailed responses are presented in the body of the report. 55 refs., 1 fig., 1 tab

  10. Implementation of Solid Waste Policies in Pernambuco: a study from the institutional theory and interorganizational networks

    Directory of Open Access Journals (Sweden)

    Maria Luciana de Almeida

    2015-09-01

    Full Text Available Solid waste is a problem in the Brazilian context, not only because it is growing in larger proportions than the population and leading to soil and water contamination, but also because it is a vector for diseases and causes economic losses, since much of what is discarded can be reused. After several years of intense debate, the Brazilian law applying to national solid waste policy was sanctioned; this law contains goals to be achieved and challenges to be overcome. Since this is a major issue, the purpose of this paper is to discuss the implementation of public policies on solid waste, emphasizing the initiatives carried out in the state of Pernambuco, from the perspectives of institutional theory and inter-organizational networks. By analysing the provisions of the law, we can observe a coercive tendency to bring the states and municipalities to establish networks in order to meet demands related to solid waste, since the pertinent legislation induces the involved entities to develop this kind of partnership in order to obtain resources

  11. 14. Policies and Institutions - Nongovernmental organizations: A growing force in the developing world

    International Nuclear Information System (INIS)

    Livernash, R.; Paden, M.

    1992-01-01

    An extraordinarily diverse and growing body of private organizations now dot the world's institutional landscape, working in a variety of areas such as small-scale local development, the conservation of tropical forests, and sustainable agriculture. Working at many levels, through example or advocacy these groups are influencing the direction of environment and development policy around the world. Non-governmental organizations (NGOs) are extraordinarily diverse. This chapter provides a few examples to capture some of that diversity, but focuses mainly on the strengths and weaknesses of NGOs, on the relationship between governments and NGOs, and on some emerging trends. The chapter primarily concerns the newly emerging grassroots and service NGOs in developing countries and those Northern NGOs that work extensively in developing countries. Topics discussed are: origins and regional differences (northern NGOs with a mission in the south, Asia, Latin America, Africa); strengths and weaknesses; key organizational factors (getting started, getting bigger, the impact of leadership, the role of women); government-NGO relations; emerging trends (evolving North-South relations, networks and associations - forging larger alliances, the information explosion global networking, new roles for policy research and legal defense)

  12. INSTITUTIONAL BARRIERS TO EFFICIENT POLICY INTERVENTION IN THE EUROPEAN PORT SECTOR

    Directory of Open Access Journals (Sweden)

    Barry UBBELS

    2005-01-01

    Full Text Available Despite the growing role of private involvement in recent port developments, most maritime trade is still largely handled in ports where investments, pricing and other managerial decisions are, to a varying extent, dependent, or at least influenced by public bodies. This paper shows that the extent and type of public intervention differs considerably between ports in the Hamburg-Le Havre range. The wide variety in ownership, financing and management of ports throughout Europe indicates that there is no level playing field at present. Because ports operate in an increasingly competitive environment (intensified by globalisation trends and the completion of the internal market, this may lead to situations of unfair competition. The European Union emphasises the importance of a more harmonised approach of port regulation by national governments (in terms of financing and pricing of infrastructure. Given the differences in (national port management styles and the low levels of transparency, the creation of a level playing field in the European port industry seems far away. This suggests the presence of a major institutional difference in European transport policy that hampers efficient policy intervention.

  13. Input–Output Matrix study: A theoretical frame to study the impact of Brazilian IPI reduction in final demand

    Directory of Open Access Journals (Sweden)

    Rodrigo Emmanuel Santana Borges

    2014-05-01

    Full Text Available The economic crisis of 2008–2009 will be known as the day when the creator knelt before its creation (Syll, 2010. Amid such economic mess created by economists (and so-called engineers themselves, there seems to be a single economic perspective: every man for himself and save yourself if you can. In the midst of this major disruption in the global economy, the Brazilian government decided, in a set of economic measures, to promote a partial and time-limited VAT reduction as its main countercyclical policy. This paper proposes to measure which were the direct and indirect effects of lowering the taxes for a limited time on production, employment generation and income. Additionally, it intends to check whether the reduction on IPI level, a tax that is one of the VATs in Brazil, was indeed the most efficient choice among the other value added taxes in Brazil. In order to accomplish such objectives, a simple final demand model for the GDP is adopted, and the latest national accounts input–output data is taken as a basis to infer the multipliers for the variables chosen and to estimate hypothetical impacts of reduction in other taxes instead of IPI reduction in the specific sector. Currently, the consensus is that the countercyclical economic policy adopted in Brazil had a positive result and fulfilled the expected goals.

  14. Individually Prescribed Instruction--Mathematics (IPI--Math). Product Development Report No. 17.

    Science.gov (United States)

    Jung, Steven M.

    This report summarizes the mathematics component of Individually Prescribed Instruction (IPI). The first section outlines the overall goals, specific objectives, and philosophy of IPI; the organization of the materials; and the procedures for their use, with emphasis on the altered role of both students and teachers. The next section describes the…

  15. Second Year Evaluation, IPI Mathematics Project; Hall School, 1970-71.

    Science.gov (United States)

    Johnson, Lary; Ostrum, Donald R.

    A pretest in mathematics determined the starting point for low-income elementary school students in a three year Individually Prescribed Instruction (IPI) project, in which each student progressed through the IPI continuum of skills at his own rate as he proved his mastery of successive skills. The results of the first two years of this project…

  16. Equity in Elementary Science Education: A Study of Institutional and Policy Factors

    Science.gov (United States)

    Hayes, Kathryn N.

    Despite recognition that the foundation for interest in science is laid down at the elementary level (Tai, et al., 2006), in the last ten years elementary science instruction time has declined in K-6 schooling (Center on Education Policy, 2007). A lack of access to excellent science education is exacerbated for low-income students, prompting significant questions regarding inequities within the science education pipeline (Maulucci, 2010). The critical factors needed to address these inequities include teacher preparation, access to resources, and instructional leadership, as well as a supportive policy and institutional milieu. However, although the former three have been studied extensively, the role of policy and institutions in creating the conditions for equity in science education are little understood despite their likely significant role (Lemke, 2001). This mixed methods study addressed this gap by examining the role the policy and institutional milieu play in constraining or supporting equitable elementary science education. Institutional theory provides the framework for understanding how various institutional logics and regulatory pressures permeate schools and districts across contexts, influencing science education implementation (Scott, 2014). Two distinct approaches were used to first quantitatively examine the predictors of differentiation in elementary science education instructional time and methods, and second qualitatively analyze the nature and process by which these mechanisms exert influence. Data for the first two papers was derived from a case study of a purposively sampled district, including surveys of 200 teachers and embedded case studies of four schools. Analysis consisted of multi-level models of teacher attributes and school and policy factors in predicting differential distribution of science education instructional time and methods (Raudenbush & Bryk, 2002). Data for the third paper arose out of a series of principal, administrator

  17. Reaching out to students across India under IPY

    Science.gov (United States)

    Tiwari, M.; Ravindra, R.

    2009-04-01

    India is actively involved in the scientific as well as the outreach activities related to IPY with National Centre for Antarctic & Ocean Research (NCAOR) as the national coordinating agency. The purpose of the Indian IPY outreach activities is to educate general public, especially school children, about Poles & specifically about Indian scientific activities that are being carried out there. It becomes an uphill task considering the vast population & area of India. To achieve this, NCAOR in collaboration with WWF-India (World Wide Fund for Nature) is organizing various activities that include competitions such as poster & model making, stamp designing, petition writing etc. for school children. NCAOR has also supplied audio-visual & printed material on polar science for organizing exhibitions that focus on geography, environment, flora, fauna, people & importance of poles along with issues related to poles such as ozone hole, global warming etc. Moreover, a popular book entitled "Story of Antarctica" is published by NCAOR & distributed to students in different states of India. To further give impetus to our outreach efforts & to engage more students, an innovative Soccer Tournament called Sub-Zero Soccer was arranged for College students, which received very enthusiastic response. The main objective is to generate awareness among the youth by engaging them in sports and culture as this is very close to their heart and appeals to them. NCAOR also has a specific student participation program in Indian Antarctic Expeditions & students on return share their experiences with other students through lectures etc. To mark the end of IPY, a whole lot of activities are being planned for the last week of February that would include street plays, lectures, question & answer sessions etc.

  18. The NSIDC DAAC's Role in Sustaining the IPY Data Legacy

    Science.gov (United States)

    Weaver, R. L.; Kaminski, M.

    2008-12-01

    NASA's Snow and Ice Distributed Active Archive Center at the National Snow and Ice Data Center (NSIDC DAAC) has been awarded a follow-on contract for the coming five years. The scope of this work is specific to NASA's Earth Observing Priorities but meshes well with International Polar Year needs. We will discuss the intended tasks for the NSIDC DAAC in relation to the needs for IPY data management, pointing out challenges to either the DAAC specifically or to the IPY community generally. The challenges to the NSIDC DAAC include better integration of our legacy data with our Earth Observing System (EOS) satellite mission data, and integration of our data and systems with the greater data management community and programs such as the IPY. We must continually improve the ways we describe and deliver our data to users, enhancing their ability to use it in innovative ways. Our approaches to meeting these objectives include: Adapting our data systems to the ever-changing user needs and technology landscape. Major thrusts include deriving gains in programmer and software engineer efficiency through greater standardization of software development processes; increasing use of subsetting to deliver larger quantities of data with available network bandwidth; standardizing metadata within the NSIDC DAAC and between our data center collaborators; harmonizing formats and spatial/temporal coverages for data and data types to enable more powerful visualization, online analysis and data integration. Implementing existing and new geophysical algorithms for cryospheric and polar processes including sea ice concentration and types, ice surface temperature, sea ice motion, ice sheet topography and ice volume change, surface albedo, snow extent, and snow water equivalent. Acquiring new data streams and developing new data products (including new data types and improved formats) to meet NASA and EOS science objectives for the cryosphere and polar regions.

  19. Development policy for non-grid-connected wind power in China: An analysis based on institutional change

    International Nuclear Information System (INIS)

    Fang Yong; Li Jing; Wang Mingming

    2012-01-01

    Government policy continues to play a crucial role in the development of wind power industry in China. The 2005 “Renewable Energy Law” and related policies have driven the rapid increase in wind power installed capacity in China over the past half-decade, with capacity doubling annually since 2005. However, a large number of wind farms generate electricity well below their installed capacity, resulting in considerable wastage of resources. Non-grid-connected wind power theory proposes that large-scale wind power output does not necessarily have to be fed into the grid, but can be used directly in industrial production. Thus, the use of the theory can promote the sustainable development of the wind power industry by obviating the need for power grid. In this paper we analyze the influence of government policy on wind power industry from the perspective of institutional change, by employing the basic theories of new institutional economics. A development model for non-grid-connected wind power is proposed in order to implement institutional change in accordance with the specific characteristics of wind power industry in China. This model requires the government to play an active role in institutional development by increasing economic efficiency in order to promote the sustainable development of wind power. - Highlights: ► New institutional economics-based analysis paradigm for wind power policy proposed. ► Policies for China's wind power industry analyzed according to the paradigm. ► Hybrid development mode of institutional change is the best pathway for wind power. ► Potential development policy for China's wind power industry recommended.

  20. An institutional approach to support the conduct and use of health policy and systems research: The Nodal Institute in the Eastern Mediterranean Region.

    Science.gov (United States)

    El-Jardali, Fadi; Saleh, Shadi; Khodor, Rawya; Abu Al Rub, Raeda; Arfa, Chokri; Ben Romdhane, Habiba; Hamadeh, Randah R

    2015-10-01

    The use of health policy and systems research (HPSR) to support decision making in health systems is limited in the Eastern Mediterranean Region (EMR). This is partly due to the lack of effective initiatives to strengthen regional HPSR capacities and promote its use in decision making. This paper offers a structured reflection on the establishment and core functioning of a HPSR Nodal Institute for the EMR with specific focus on the approach used to support the conduct and use of HPSR. It seeks to gain better understanding of the activities conducted by the Nodal Institute, the methods by which the Nodal Institute implemented these activities, and the outcomes of these activities. A multi-faceted approach was implemented by the Nodal Institute in collaboration with regional academic/research institutions, Sub-Nodes. The overall approach was a phased one that included the selection of Sub-Nodes, mapping of academic/research institutions in the EMR, stakeholders' meetings, and HPSR capacity building workshops, and culminated with a regional meeting. The mapping of academic/research institutions in the EMR resulted in the identification of 50 institutions, of which only 32 were engaged in HPSR. These institutions have the highest HPSR involvement in information/evidence (84%) and the lowest in human resources for health (34%). Their main HPSR focus areas included quality of healthcare services, patient safety, management of non-communicable diseases, and human resources for health. Regional HPSR challenges among these institutions were identified. The validation and ranking questionnaires resulted in the identification of country-specific HPSR priorities according to stakeholders in three countries. From these results, cross-cutting HPSR priorities among the countries related to primary healthcare, non-communicable diseases, human resources for health, as well as cross-cutting HPSR priorities among stakeholders and according to stakeholders of the countries, were

  1. World bank's role in the electric power sector: Policies for effective institutional, regulatory, and financial reform. World Bank policy paper

    International Nuclear Information System (INIS)

    1993-01-01

    The policy paper is based on the World Bank Industry and Energy Department's ongoing policy and research work, which (1) examines experiences of industrial countries and the Bank's borrowers in developing their power sectors, (2) analyzes issues facing these sectors, and (3) describes options for dealing with these issues in developing countries. The paper is supported by a large body of research

  2. A comparison of bioenergy policies and institutional frameworks in the rural areas of Emilia Romagna and Norway

    International Nuclear Information System (INIS)

    Cavicchi, Bianca; Bryden, John M.; Vittuari, Matteo

    2014-01-01

    This paper explores the relationship between bioenergy, rural development and related innovation processes in two case studies (Emilia Romagna in Italy—and Norway), for a better understanding of the impacts of different policy regimes on bioenergy innovation. Regional innovation systems theory is used to explain the results emerging from the case studies and to identify the presence of potential elements for innovation. We used policy and relevant literature analysis and a grounded approach based on semi- structured interviews of relevant actors involved in the local bioenergy system. The main findings show that the case studies present consistent differences in terms of policy instruments and socio-political dynamics. Emilia Romagna has major weaknesses and threats that hinder innovation, but some positive potential elements for the future. Norway presents stronger local elements for innovation within local bioenergy systems, such as the employment of local resources and knowledge, but critical market and policy features that threaten further innovation developments. The conclusion draws on the comparative analysis to discuss policy implications of the study. - Highlights: • We compare policies and institutional frameworks which regulate bioenergy systems. • We use the SWOT analysis to evaluate the results of the case studies. • Emilia Romagna has major systemic weaknesses. • Norway has local elements for innovation but policy weaknesses. • Policies and policy instruments should be decentralised

  3. Dynamic mobility applications policy analysis : policy and institutional issues for enabling advanced traveler information services (EnableATIS).

    Science.gov (United States)

    2014-10-01

    This report documents policy considerations for Enabling Advanced Traveler Information Services, or EnableATIS. : EnableATIS is the traveler information element of the Dynamic Mobility Applications program, and it provides a framework to : develop mu...

  4. Illegal drugs, anti-drug policy failure, and the need for institutional reforms in Colombia.

    Science.gov (United States)

    Thoumi, Francisco E

    2012-01-01

    This paper is inspired by two anomalies encountered in the study of the illegal drugs industry. First, despite the very high profits of coca/cocaine and poppy/opium/heroin production, most countries that can produce do not. Why, for example, does Colombia face much greater competition in the international coffee, banana, and other legal product markets than in cocaine? And second, though illegal drugs are clearly associated with violence, why is it that illegal drug trafficking organizations have been so much more violent in Colombia and Mexico than in the rest of the world? The answers to these questions cannot be found in factors external to Colombia (and Mexico). They require identifying the societal weaknesses of each country. To do so, the history of the illegal drugs industry is surveyed, a simple model of human behavior that stresses the conflict between formal (legal) and informal (socially accepted) norms as a source of the weaknesses that make societies vulnerable is formulated. The reasons why there is a wide gap between formal and informal norms in Colombia are explored and the effectiveness of anti-drug policies is considered to explain why they fail to achieve their posited goals. The essay ends with reflections and conclusion on the need for institutional change.

  5. Collection Development and Circulation Policies in Prison Libraries: An Exploratory Survey of Librarians in US Correctional Institutions

    Science.gov (United States)

    Conrad, Suzanna

    2012-01-01

    Prison libraries have traditionally fulfilled many purposes for their incarcerated patrons, and these libraries often carry a diverse collection to serve varied patron needs. However, during the trial of Steven Hayes for the Petit family murders, the prosecution questioned the collection development policies of the institutions where Hayes had…

  6. An International Orientation on Institutional Strategies and Governmental Policies for the Use of ICT in Higher Education

    NARCIS (Netherlands)

    van der Wende, Marijk; Beerkens, Eric

    1999-01-01

    This article provides an international comparative overview of institutional strategies, collaboration patterns and governmental policies related to the use of ICT in higher education. It has been produced as part of an international comparative study on the use of ICT in higher education. A study

  7. Participation Patterns in Adult Education: The Role of Institutions and Public Policy Frameworks in Resolving Coordination Problems

    Science.gov (United States)

    Desjardins, Richard; Rubenson, Kjell

    2013-01-01

    This article focuses on evidence regarding cross-national patterns of participation in adult education and an interpretation of these patterns from an institutional and public policy perspective. The interpretation follows from the perspective that sustaining high and widely distributed levels of investment in the development and maintenance of…

  8. Police, Design, Plan and Manage: Developing a Framework for Integrating Staff Roles and Institutional Policies into a Plagiarism Prevention Strategy

    Science.gov (United States)

    Walker, Christopher; White, Melanie

    2014-01-01

    When student plagiarism occurs, academic interest and institutional policy generally assume the fault rests with the student. This paper questions this assumption. We claim that plagiarism is a shared responsibility and a complex phenomenon that requires an ongoing calibration of the relative skills and experiences of students and staff in…

  9. Suicide Risk Response: Enhancing Patient Safety Through Development of Effective Institutional Policies

    National Research Council Canada - National Science Library

    Bonner, Laura; Felker, Bradford; Chaney, Edmund; Vollen, Karen; Berry, Karen; Revay, Barbara; Simon, Barbara; Kofoed, Lial; Ober, Scott; Worley, Linda

    2004-01-01

    A suicidal patient requires a prompt, coordinated intervention. In this paper, we describe a process for developing a suicidality policy, which may help clinics develop effective, locally adapted policies...

  10. Hispanic-Serving Institutions: Patterns, Predictions, and Implications for Informing Policy Discussions

    Science.gov (United States)

    Torres, Vasti; Zerquera, Desiree

    2012-01-01

    This article seeks to identify and assess the readiness of "Potential" Hispanic-Serving Institutions (HSIs)--institutions located within Latino communities projected to increase the number of Latino/a high school graduates. Institutions are described based on evaluation of institutional missions, planning documents, programs, and marketing…

  11. Food and sustainability: local and organic food in Finnish food policy and in institutional kitchens

    OpenAIRE

    Risku-Norja, Helmi; Muukka, Eija

    2013-01-01

    This article probes a number of recent national policy documents in order to capture how sustainability is perceived and expressed in the context of food and what role is given to the alternative food supplies. The goals of food policy and their realization are discussed by reflecting the results from the policy document analysis against the actual use of alternative food in the statutory municipal catering services in Finland. In the policy documents the concept of sustainable development ha...

  12. COLLABORATIVE POLICY-MAKING, LAW STUDENTS, AND ACCESS TO JUSTICE: THE REWARDS OF DESTABILIZING INSTITUTIONAL PATTERNS

    Directory of Open Access Journals (Sweden)

    Brea Lowenberger

    2017-12-01

    Full Text Available Heightened concerns and dialogue about access to justice have infused the law school setting in Saskatchewan and, to varying degrees, across the country. If there ever were a time to approach social justice reform differently – to upset traditional parameters around decision making and step around older hierarchies for input and design – it would be now. This article describes the Dean’s Forum on Dispute Resolution and Access to Justice (colloquially known as the Dean’s Forum as a platform for genuine student engagement in the development of public policy in this important area. We offer our combined reflections, gathered inside our “teaching team,” about the unique pedagogical features of our experiment and its challenges. As we continue to grow with the project, we offer this Saskatchewan story as one example of institutional collaboration in a quickly evolving educational and social policy landscape.   L’accès à la justice est une préoccupation croissante et un thème de plus en plus récurrent dans les facultés de droit de la Saskatchewan et, à différents degrés, de l’ensemble du pays. Le temps est venu, semble-t-il, d’aborder la réforme de la justice sociale différemment, de bouleverser les paramètres traditionnels gravitant autour de la prise de décisions et de contourner les hiérarchies plus anciennes en ce qui concerne les données et les concepts. Cet article porte sur le forum du doyen concernant le règlement des conflits et l’accès à la justice (familièrement appelé le Dean’s Forum (forum du doyen comme plateforme pour la participation des étudiants à l’élaboration des politiques publiques dans cet important domaine. Nous présentons l’ensemble des réflexions de notre équipe d’enseignants au sujet des éléments pédagogiques uniques de notre expérience et des difficultés connexes. Nous continuons à grandir avec notre projet, mais nous souhaitions décrire dès maintenant cette

  13. Introduction to Dossier: Lessons from Latin America on the rational choice, cognitive and institutional approaches to policy change

    Directory of Open Access Journals (Sweden)

    Fontaine, Guillaume

    2015-09-01

    Full Text Available A review of the pertinent academic literature identifies three analytical focuses in studies of policy change. Rational choice- with its theories of incrementalism, multiple currents and punctuated equilibrium- privilege the decision-making process and the rational nature of the individual actor. The cognitivists- with their framework of promoter coalitions, the theory of social/ global references and critical theory- emphasize the presentation of policy problems and the legitimating discourse behind the decision-making process. The neo-institutionalist- with their theories of the logic of the adequate, path dependence and the three-order process of policy change- emphasize the importance of formal and informal institutions in the development of public policies.

  14. Institutional factors of energy policy in the Federal Republic of Germany

    International Nuclear Information System (INIS)

    Rehfeld, D.

    1986-01-01

    Energy policy serves to demonstrate the interrelation of political field analysis and conceptional political discussion. A theoretical political field analysis results in the fact that energy policy must not be considered a clearly defined political field but rather a domain affected by economic policy. Based on this principle the publication is entering into an empirically founded discussion of topical aspects of political science (policy science, corporatism, governability, marxian theories). The respective problems at issue are applied to energy policy in order to work out the potential and topical problems of all aspects involved. (orig.) [de

  15. Survey of Policies and Guidelines on Antioxidant Use for Cancer Prevention, Treatment, and Survivorship in North American Cancer Centers: What Do Institutions Perceive as Evidence?

    Science.gov (United States)

    Hong, Gyeongyeon; White, Jennifer; Zhong, Lihong; Carlson, Linda E

    2015-07-01

    Health care policies and guidelines that are clear and consistent with research evidence are important for maximizing clinical outcomes. To determine whether cancer centers in Canada and the United States had policies and/or guidelines about antioxidant use, and whether policies were aligned with the evidence base, we reviewed current research evidence in the field, and we undertook a survey of the policies and guidelines on antioxidant use at cancer institutions across North America. A survey of policies and guidelines on antioxidant use and the development and communication of the policies and guidelines was conducted by contacting cancer institutions in North America. We also conducted a Website search for each institution to explore any online resources. Policies and guidelines on antioxidant use were collected from 78 cancer institutions. Few cancer institutions had policies (5%) but most provided guidelines (69%). Antioxidants from diet were generally encouraged at cancer institutions, consistent with the current research evidence. In contrast, specific antioxidant supplements were generally not recommended at cancer institutions. Policies and guidelines were developed using evidence-based methods (53%), by consulting another source (35%), or through discussions/conference (26%), and communicated mainly through online resources (65%) or written handouts (42%). For cancer institutions that had no policy or guideline on antioxidants, lack of information and lack of time were the most frequently cited reasons. Policies and guidelines on antioxidants from diet were largely consistent with the research evidence. Policies and guidelines on antioxidant supplements during treatment were generally more restrictive than the research evidence might suggest, perhaps due to the specificity of results and the inability to generalize findings across antioxidants, adding to the complexity of their optimal and safe use. Improved communication of comprehensive research

  16. Undocumented Immigrants and Institutional Admission Policy Transformation in a Community College: Exploring Policy-Making and Its Consequences

    Science.gov (United States)

    Kim, Eunyoung; Chambers, Jessica A.

    2015-01-01

    Much of the research on undocumented students has primarily addressed the effects of state policy on undocumented students' access to college and financial aid; it has also examined the educational experiences and challenges unique to undocumented students. However, current literature lacks a thorough investigation of how community colleges…

  17. A comparative institutional analysis of the Fukushima nuclear disaster: Lessons and policy implications

    International Nuclear Information System (INIS)

    Aoki, Masahiko; Rothwell, Geoffrey

    2013-01-01

    This paper analyzes the causes, responses, and consequences of the Fukushima nuclear power plant accident (March 2011) by comparing these with Three Mile Island (March 1979) and Chernobyl (April 1986). We identify three generic modes of organizational coordination: modular, vertical, and horizontal. By relying on comparative institutional analysis, we compare the modes' performance characteristics in terms of short-term and long-term coordination, preparedness for shocks, and responsiveness to shocks. We derive general lessons, including the identification of three shortcomings of integrated Japanese electric utilities: (1) decision instability that can lead to system failure after a large shock, (2) poor incentives to innovate, and (3) the lack of defense-in-depth strategies for accidents. Our suggested policy response is to introduce an independent Nuclear Safety Commission, and an Independent System Operator to coordinate buyers and sellers on publicly owned transmission grids. Without an independent safety regulator, or a very well established “safety culture,” profit-maximizing behavior by an entrenched electricity monopoly will not necessarily lead to a social optimum with regard to nuclear power plant safety. All countries considering continued operation or expansion of their nuclear power industries must strive to establish independent, competent, and respected safety regulators, or prepare for nuclear power plant accidents. - Highlights: ► We review damage to Fukushima Dai-Ichi on March 11, 2011, from the Tōhoku earthquake and tsunami. ► We find that delays in coordinated action led to a cascading series of accidents at Fukushima. ► We suggest unbundling of the publicly purchased Tokyo Electric Power to pay for accident damages. ► We suggest the creation of a Japanese Independent System Operator to manage unbundled transmission assets. ► We propose establishing an open-interface, rule-based independent nuclear regulator in Japan.

  18. Outcome prediction by extranodal involvement, IPI, R-IPI, and NCCN-IPI in the PET/CT and rituximab era: A Danish-Canadian study of 443 patients with diffuse-large B-cell lymphoma.

    Science.gov (United States)

    El-Galaly, Tarec Christoffer; Villa, Diego; Alzahrani, Musa; Hansen, Jakob Werner; Sehn, Laurie H; Wilson, Don; de Nully Brown, Peter; Loft, Annika; Iyer, Victor; Johnsen, Hans Erik; Savage, Kerry J; Connors, Joseph M; Hutchings, Martin

    2015-11-01

    18F-fluorodeoxyglucose PET/CT (PET/CT) is the current state-of-the-art in the staging of diffuse large B-cell lymphoma (DLBCL) and has a high sensitivity for extranodal involvement. Therefore, reassessment of extranodal involvement and the current prognostic indices in the PET/CT era is warranted. We screened patients with newly diagnosed DLBCL seen at the academic centers of Aalborg, Copenhagen, and British Columbia for eligibility. Patients that had been staged with PET/CT and treated with R-CHOP(-like) 1(st) line treatment were retrospectively included. In total 443 patients met the inclusion criteria. With a median follow-up of 2.4 years, the 3-year overall (OS) and progression-free survival (PFS) were 73% and 69%, respectively. The Ann Arbor classification had no prognostic impact in itself with the exception of stage IV disease (HR 2.14 for PFS, P2 extranodal sites, including HR 7.81 (P 3 sites. Bone/bone marrow involvement was the most commonly involved extranodal site identified by PET/CT (29%) and was associated with an inferior PFS and OS. The IPI, R-IPI, and NCCN-IPI were predictive of PFS and OS, and the two latter could identify a very good prognostic subgroup with 3-year PFS and OS of 100%. PET/CT-ascertained extranodal involvement in DLBCL is common and involvement of >2 extranodal sites is associated with a dismal outcome. The IPI, R-IPI, and NCCN-IPI predict outcome with high accuracy. © 2015 Wiley Periodicals, Inc.

  19. The revised International Prognostic Index (R-IPI) is a better predictor of outcome than the standard IPI for patients with diffuse large B-cell lymphoma treated with R-CHOP.

    Science.gov (United States)

    Sehn, Laurie H; Berry, Brian; Chhanabhai, Mukesh; Fitzgerald, Catherine; Gill, Karamjit; Hoskins, Paul; Klasa, Richard; Savage, Kerry J; Shenkier, Tamara; Sutherland, Judy; Gascoyne, Randy D; Connors, Joseph M

    2007-03-01

    Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous entity, with patients exhibiting a wide range of outcomes. The addition of rituximab to CHOP chemotherapy (R-CHOP)has led to a marked improvement in survival and has called into question the significance of previously recognized prognostic markers. Since randomized controlled trials of R-CHOP in DLBCL have included select subgroups of patients, the utility of the International Prognostic Index (IPI) has not been reassessed. We performed a retrospective analysis of patients with DLBCL treated with R-CHOP in the province of British Columbia to assess the value of the IPI in the era of immunochemotherapy. The IPI remains predictive, but it identifies only 2 risk groups. Redistribution of the IPI factors into a revised IPI (R-IPI) provides a more clinically useful prediction of outcome. The R-IPI identifies 3 distinct prognostic groups with a very good (4-year progression-free survival [PFS] 94%, overall survival [OS] 94%), good (4-year PFS 80%, OS 79%), and poor (4-year PFS 53%, OS 55%) outcome, respectively (P IPI (or R-IPI) no longer identifies a risk group with less than a 50% chance of survival. In the era of R-CHOP treatment, the R-IPI is a clinically useful prognostic index that may help guide treatment planning and interpretation of clinical trials.

  20. MYC and BCL-2 adjusted-International Prognostic Index (A-IPI) is a better predictor of outcome than the standard IPI for patients with diffuse large B-cell lymphoma treated with R-CHOP.

    Science.gov (United States)

    Wang, Jing; Zhou, Min; Xu, Jing-Yan; Yang, Yong-Gong; Zhang, Qi-Guo; Zhou, Rong-Fu; Chen, Bing; Ouyang, Jian; Li, Cuiping

    2016-03-01

    The International Prognostic Index (IPI) has been the basis for determining prognosis in patients with diffuse large B-cell lymphoma (DLBCL) for the past 20 years. The utility of the IPI must be reassessed in the era of immunochemotherapy. Seven risk factors at diagnosis were identified, and a maximum of 7 points were assigned to each patient. Four risk groups were created: low (0-1), low-intermediate (2-3), high-intermediate (4), and high (5-7). Using MYC and BCL-2 clinical data from the Drum Tower Hospital collected during the rituximab era, we performed a retrospective analysis of patients with DLBCL treated with R-CHOP and built an biological markers adjusted IPI with the goal of improving risk stratification.Clinical features from 60 adults with de novo DLBCL diagnosed from 2008-2013 were assessed for their prognostic significance. The IPI remains predictive, but it cannot identify the high-risk subgroup. Compared with the IPI, the MYC and BCL-2 adjusted-IPI (A-IPI) better discriminated patients in the high-risk subgroup (4-year overall survival [OS]: 33.3%) than did the IPI (4 year OS: 48.0%). In the era of R-CHOP treatment, MYC and BCL-2 adjusted-IPI is more powerful than the IPI for helping guide treatment planning and interpretation of clinical trials.

  1. Ideas, actors and institutions: lessons from South Australian Health in All Policies on what encourages other sectors' involvement.

    Science.gov (United States)

    Baum, Fran; Delany-Crowe, Toni; MacDougall, Colin; Lawless, Angela; van Eyk, Helen; Williams, Carmel

    2017-10-16

    This paper examines the extent to which actors from sectors other than health engaged with the South Australian Health in All Policies (HiAP) initiative, determines why they were prepared to do so and explains the mechanisms by which successful engagement happened. This examination applies theories of policy development and implementation. The paper draws on a five year study of the implementation of HiAP comprising document analysis, a log of key events, detailed interviews with 64 policy actors and two surveys of public servants. The findings are analysed within an institutional policy analysis framework and examine the extent to which ideas, institutional factors and actor agency influenced the willingness of actors from other sectors to work with Health sector staff under the HiAP initiative. In terms of ideas, there was wide acceptance of the role of social determinants in shaping health and the importance of action to promote health in all government agencies. The institutional environment was initially supportive, but support waned over the course of the study when the economy in South Australia became less buoyant and a health minister less supportive of health promotion took office. The existence of a HiAP Unit was very helpful for gaining support from other sectors. A new Public Health Act offered some promise of institutionalising the HiAP approach and ideas. The analysis concludes that a key factor was the operation of a supportive network of public servants who promoted HiAP, including some who were senior and influential. The South Australian case study demonstrates that despite institutional constraints and shifting political support within the health sector, HiAP gained traction in other sectors. The key factors that encouraged the commitment of others sectors to HiAP were the existence of a supportive, knowledgeable policy network, political support, institutionalisation of the ideas and approach, and balancing of the economic and social goals of

  2. Ideas, actors and institutions: lessons from South Australian Health in All Policies on what encourages other sectors’ involvement

    Directory of Open Access Journals (Sweden)

    Fran Baum

    2017-10-01

    Full Text Available Abstract Background This paper examines the extent to which actors from sectors other than health engaged with the South Australian Health in All Policies (HiAP initiative, determines why they were prepared to do so and explains the mechanisms by which successful engagement happened. This examination applies theories of policy development and implementation. Methods The paper draws on a five year study of the implementation of HiAP comprising document analysis, a log of key events, detailed interviews with 64 policy actors and two surveys of public servants. Results The findings are analysed within an institutional policy analysis framework and examine the extent to which ideas, institutional factors and actor agency influenced the willingness of actors from other sectors to work with Health sector staff under the HiAP initiative. In terms of ideas, there was wide acceptance of the role of social determinants in shaping health and the importance of action to promote health in all government agencies. The institutional environment was initially supportive, but support waned over the course of the study when the economy in South Australia became less buoyant and a health minister less supportive of health promotion took office. The existence of a HiAP Unit was very helpful for gaining support from other sectors. A new Public Health Act offered some promise of institutionalising the HiAP approach and ideas. The analysis concludes that a key factor was the operation of a supportive network of public servants who promoted HiAP, including some who were senior and influential. Conclusions The South Australian case study demonstrates that despite institutional constraints and shifting political support within the health sector, HiAP gained traction in other sectors. The key factors that encouraged the commitment of others sectors to HiAP were the existence of a supportive, knowledgeable policy network, political support, institutionalisation of the

  3. Local Irrigation Management Institutions Mediate Changes Driven by External Policy and Market Pressures in Nepal and Thailand

    Science.gov (United States)

    Bastakoti, Ram C.; Shivakoti, Ganesh P.; Lebel, Louis

    2010-09-01

    This article assesses the role of local institutions in managing irrigation water use. Fifty irrigation systems in each country were studied in Nepal and Thailand to compare the influence of local institutions on performance of irrigation systems amid changes in external policy and market pressures. Nepal’s new irrigation policy after the re-instatement of multiparty democracy in 1990 emphasized participatory irrigation management transferring the management responsibility from state authorities to water users. The water user associations of traditional farmer-managed irrigation systems were formally recognized by requiring registration with related state authorities. In Thailand also government policies encouraged people’s participation in irrigation management. Today water users are directly involved in management of even some large irrigation systems at the level of tertiary canals. Traditional communal irrigation systems in northern Thailand received support for system infrastructure improvement but have faced increased interference from government. In Thailand market development supported diversification in farming practices resulting in increased areas under high water-demanding commercial crops in the dry season. In contrast, the command areas of most irrigation systems in Nepal include cereal-based subsistence farming with only one-third having commercial farming. Cropping intensities are higher in Nepal than in Thailand reflecting, in part, differences in availability of land and management. In both countries local institutions play an important role in maintaining the performance of irrigation systems as external drivers and local contexts change. Local institutions have provided alternative options for irrigation water use by mediating external pressures.

  4. Groundwater socio-ecology and governance: a review of institutions and policies in selected countries

    Science.gov (United States)

    Mukherji, Aditi; Shah, Tushaar

    2005-03-01

    Groundwater is crucial for the livelihoods and food security of millions of people, and yet, knowledge formation in the field of groundwater has remained asymmetrical. While, scientific knowledge in the discipline (hydrology and hydrogeology) has advanced remarkably, relatively little is known about the socio-economic impacts and institutions that govern groundwater use. This paper therefore has two objectives. The first is to provide a balanced view of the plus and the down side of groundwater use, especially in agriculture. In doing so, examples are drawn from countries such as India, Pakistan, Bangladesh, China, Spain and Mexico—all of which make very intensive use of groundwater. Second, institutions and policies that influence groundwater use are analyzed in order to understand how groundwater is governed in these countries and whether successful models of governance could be replicated elsewhere. Finally, the authors argue that there is a need for a paradigm shift in the way groundwater is presently perceived and managed—from management to governance mode. In this attempt, a number of instruments such as direct regulation, indirect policy levers, livelihood adaptation and people's participation will have to be deployed simultaneously in a quest for better governance. L'eau souterraine est cruciale pour la survie et la sécurité alimentaire de plusieurs millions de personnes mais cependant la foramtion en matière d'eaux souterraines reste asymmétrique. Alors que la connaissance scientifique dans la discipline (hydrologie et hydrogéologie) a avancée de manière remarquable, on connaît peu de choses sur les impacts socio-économiques et les institutions qui gouvernent l'utilisation des eaux souterraines. Cet article a par conséquent deux objectifs. Le premier est d'assurer un point de vue balancé entre le côté positif et le côté négatif de l'utilisation de l'eau souterraine, spécialement en agriculture. De cette manière, des exemples d

  5. SOME QUESTIONS OF INSTITUTIONAL CHANGES IN THE STRUCTURAL POLICY IN THE TRANSITIONAL ECONOMY OF THE REPUBLIC OF TAJIKISTAN

    Directory of Open Access Journals (Sweden)

    Vakhobov A. A.

    2014-09-01

    Full Text Available The article examines patterns of structural change in the transformation to ensure the sustainability of economic growth as the base address socio-economic problems in the national economy. Author, classified and disclosed the concept of structural policies outlined in the article. And theoretically analyzed the problem of macroeconomic policies and institutional reforms in the current stage of market reforms in the Republic of Tajikistan. The main factors to reform laws and achieve economic independence of the state, through the creation of a favorable investment climate.

  6. Student Governance and Institutional Policy: Formation and Implementation. Educational Policy in the 21st Century: Opportunities, Challenges and Solutions

    Science.gov (United States)

    Miller, Michael T., Ed.; Nadler, Daniel P., Ed.

    2006-01-01

    Colleges and universities face a variety of challenges in meeting the needs of students, and one of the greatest is their ability to respond to student needs while protecting institutional and academic integrity. For those working with students, a primary example of this challenge is the involvement of students in shared decision-making, a process…

  7. Instituting a smoke-free policy for city recreation centers and playgrounds, Philadelphia, Pennsylvania, 2010.

    Science.gov (United States)

    Leung, Raymond; Mallya, Giridhar; Dean, Lorraine T; Rizvi, Amna; Dignam, Leo; Schwarz, Donald F

    2013-07-11

    In the United States, more than 600 municipalities have smoke-free parks, and more than 100 have smoke-free beaches. Nevertheless, adoption of outdoor smoke-free policies has been slow in certain regions. Critical to widespread adoption is the sharing of knowledge about the policy development and implementation process. In this article, we describe our experience in making City of Philadelphia recreation centers and playgrounds smoke-free. Of the 10 largest US cities, Philadelphia has among the highest rates of adult and youth smoking. Our objectives for an outdoor smoke-free policy included protecting against secondhand smoke, supporting a normative message that smoking is harmful, motivating smokers to quit, and mitigating tobacco-related sanitation costs. The Philadelphia Department of Public Health and the Department of Parks and Recreation engaged civic leaders, agency staff, and community stakeholders in the following steps: 1) making the policy case, 2) vetting policy options and engaging stakeholders, and 3) implementing policy. Near-term policy impacts were assessed through available data sources. More than 220 recreation centers, playgrounds, and outdoor pools became smoke-free through a combined mayoral executive order and agency regulation. Support for the policy was high. Estimates suggest a policy reach of 3.6 million annual visitors and almost 850 acres of new smoke-free municipal property. Localities can successfully implement outdoor smoke-free policies with careful planning and execution. Such policies hold great potential for reducing exposure to secondhand smoke, promoting nonsmoking norms, and providing additional motivation for residents to quit smoking.

  8. Using of direct imaging and IPI techniques for measurements in nozzle sprays

    Science.gov (United States)

    Andrei, Sukhanovskii; Vladimir, Batalov; Rodion, Stepanov

    2016-10-01

    Two different techniques for droplet sizing were applied for measurements in dense nozzle sprays. Measurements were carried out for different flow rates of water and intensity of air blowing in a purger. It was found that IPI and GPT distributions are essentially different. The change of air blowing substantially change droplets distribution for both IPI and GPT measurements. Important feature of developed GPT technique is application for helicity measurements.

  9. Phase I study of the Hedgehog pathway inhibitor IPI-926 in adult patients with solid tumors.

    Science.gov (United States)

    Jimeno, Antonio; Weiss, Glen J; Miller, Wilson H; Gettinger, Scott; Eigl, Bernard J C; Chang, Anne Lynne S; Dunbar, Joi; Devens, Shannon; Faia, Kerrie; Skliris, Georgios; Kutok, Jeff; Lewis, Karl D; Tibes, Raoul; Sharfman, William H; Ross, Robert W; Rudin, Charles M

    2013-05-15

    To conduct a first-in-human phase I study to determine the dose-limiting toxicities (DLT), characterize the pharmacokinetic profile, and document the antitumor activity of IPI-926, a new chemical entity that inhibits the Hedgehog pathway (HhP). Patients with solid tumors refractory to standard therapy were given IPI-926 once daily (QD) by mouth in 28-day cycles. The starting dose was 20 mg, and an accelerated titration schedule was used until standard 3 + 3 dose-escalation cohorts were implemented. Pharmacokinetics were evaluated on day -7 and day 22 of cycle 1. Ninety-four patients (32F, 62M; ages, 39-87) received doses ranging from 20 to 210 mg QD. Dose levels up to and including 160 mg administered QD were well tolerated. Toxicities consisted of reversible elevations in aspartate aminotransferase (AST), alanine aminotransferase (ALT) and bilirubin, fatigue, nausea, alopecia, and muscle spasms. IPI-926 was not associated with hematologic toxicity. IPI-926 pharmacokinetics were characterized by a slow absorption (T(max) = 2-8 hours) and a terminal half-life (t(1/2)) between 20 and 40 hours, supporting QD dosing. Of those HhP inhibitor-naïve patients with basal cell carcinoma (BCC) who received more than one dose of IPI-926 and had a follow-up clinical or Response Evaluation Criteria in Solid Tumors (RECIST) assessment, nearly a third (8 of 28 patients) showed a response to IPI-926 at doses ≥130 mg. IPI-926 was well tolerated up to 160 mg QD within 28-day cycles, which was established as the recommended phase II dose and schedule for this agent. Single-agent activity of IPI-926 was observed in HhP inhibitor-naïve patients with BCC. ©2013 AACR

  10. Environmental Policy Convergence in Europe : the impact of international institutions and trade

    NARCIS (Netherlands)

    Holzinger, K.; Knill, C.; Arts, B.

    2008-01-01

    Abstract Has globalisation led to a convergence in policy-making across nations and, if so, what are the causal mechanisms? This book analyses the extent to which the environmental policies of nation states have converged over the last thirty years and whether this convergence led to a strengthening

  11. Two Decades of E-Learning Policy Evolution at EU Level: Motivations, Institutions and Instruments

    Science.gov (United States)

    Salajan, Florin D.; Roumell, Elizabeth A.

    2016-01-01

    This article records and documents the historical development of e-learning policies at EU level by conducting a discourse and content analysis of four key e-learning policy documents drafted and implemented by the European Commission over the past 20 years: "Learning in the Information Society: Action Plan for a European Education…

  12. Crossing Science-Policy-Societal Boundaries to Reduce Scientific and Institutional Uncertainty in Small-Scale Fisheries

    Science.gov (United States)

    Sutton, Abigail M.; Rudd, Murray A.

    2016-10-01

    The governance of small-scale fisheries (SSF) is challenging due to the uncertainty, complexity, and interconnectedness of social, political, ecological, and economical processes. Conventional SSF management has focused on a centralized and top-down approach. A major criticism of conventional management is the over-reliance on `expert science' to guide decision-making and poor consideration of fishers' contextually rich knowledge. That is thought to exacerbate the already low governance potential of SSF. Integrating scientific knowledge with fishers' knowledge is increasingly popular and is often assumed to help reduce levels of biophysical and institutional uncertainties. Many projects aimed at encouraging knowledge integration have, however, been unsuccessful. Our objective in this research was to assess factors that influence knowledge integration and the uptake of integrated knowledge into policy-making. We report results from 54 semi-structured interviews with SSF researchers and practitioners from around the globe. Our analysis is framed in terms of scientific credibility, societal legitimacy, and policy saliency, and we discuss cases that have been partially or fully successful in reducing uncertainty via push-and-pull-oriented boundary crossing initiatives. Our findings suggest that two important factors affect the science-policy-societal boundary: a lack of consensus among stakeholders about what constitutes credible knowledge and institutional uncertainty resulting from shifting policies and leadership change. A lack of training for scientific leaders and an apparent `shelf-life' for community organizations highlight the importance of ongoing institutional support for knowledge integration projects. Institutional support may be enhanced through such investments, such as capacity building and specialized platforms for knowledge integration.

  13. Fostering the institutional repository through policies and interoperability with online services: the case of La Plata National University

    OpenAIRE

    Villarreal, Gonzalo Luján; Terruzzi, Franco Agustín; Lira, Ariel Jorge; Texier, José

    2015-01-01

    This article presents the work being done by La Plata National University (Universidad Nacional de La Plata, UNLP) to ensure both the preservation and dissemination of its academic and scientific output. To this end, the university has established a combination of institutional policies, workflows among departments, and services and sofware developments for its programs and projects. Developments focused on importing and exporting metadata between DSpace – the sofware used by the UNLP main re...

  14. The Influence Of Policy Implementation From The Change Of Institutional Status Toward Quality Of Patient Service In Hospital

    Directory of Open Access Journals (Sweden)

    Dadang Kusnadi

    2015-08-01

    Full Text Available Abstract Fenomenon and comunity problem in goverment hospital management not aware to wont and need public. Silent safety and consumen satisfaction is fenomenon lack quallity care. Goal this research goal for analysis about influence of policy implementation of hospital change institution status to the quality of patien service in Hospital. Kind of reserch is the quantity desain on approach the eksplanatory survey research analysis regresi linier multipel with analysis method validitas product moment pearson exam and reliability exam is alpha cronbach technique to hypotesis exam is path analysis and statistic exam t. Datum transformation is Skala Likert with measurement the method succesive interval. The population one thausand seventh two person with sample technique stratified random sampling the instrument research is quesioner and interview patien on caunter imforman. The result of assuming research that it is anticipated that implementation of change policy of institution status of hospital X there is significant influence to quality of service of patient Y is 66.31 and the other factor e is 33.69. In the implementation factor is significant to positif influence to quality service is communication X1 is 049 human resources X2 is 025 disposition X3 is 032 and structure birocratic X4 is 033. The conculsion from four factor independen variable X is the implementation of policy to quality service patient Y to influence and can receive in knowledge. To concept the development in implementation of policy need culture job factor because every product policy to contac direct with the community as to basic public policy.

  15. Observations of surface radiation and stratospheric processes at Thule Air Base, Greenland, during the IPY

    Directory of Open Access Journals (Sweden)

    Giovanni Muscari

    2014-06-01

    Full Text Available Ground-based measurements of atmospheric parameters have been carried out for more than 20 years at the Network for the Detection of Atmospheric Composition Change (NDACC station at Thule Air Base (76.5°N, 68.8°W, on the north-western coast of Greenland. Various instruments dedicated to the study of the lower and middle polar atmosphere are installed at Thule in the framework of a long standing collaboration among Danish, Italian, and US research institutes and universities. This effort aims at monitoring the composition, structure and dynamics of the polar stratosphere, and at studying the Arctic energy budget and the role played by different factors, such as aerosols, water vapour, and surface albedo. During the International Polar Year (IPY, in winter 2008-2009, an intensive measurement campaign was conducted at Thule within the framework of the IPY project “Ozone layer and UV radiation in a changing climate evaluated during IPY” (ORACLE-O3 which sought to improve our understanding of the complex mechanisms that lead to the Arctic stratospheric O3 depletion. The campaign involved a lidar system, measuring aerosol backscatter and depolarization ratios up to 35 km and atmospheric temperature profiles from 25 to 70 km altitude, a ground-based millimeter-wave spectrometer (GBMS used to derive stratospheric mixing ratio profiles of different chemical species involved in the stratospheric ozone depletion cycle, and then ground-based radiometers and a Cimel sunphotometer to study the Arctic radiative budget at the surface. The observations show that the surface radiation budget is mainly regulated by the longwave component throughout most of the year. Clouds have a significant impact contributing to enhance the role of longwave radiation. Besides clouds, water vapour seasonal changes produce the largest modification in the shortwave component at the surface, followed by changes in surface albedo and in aerosol amounts. For what concerns the

  16. The Novel HSP90 inhibitor, IPI-493, is highly effective in human gastrostrointestinal stromal tumor xenografts carrying heterogeneous KIT mutations.

    Science.gov (United States)

    Floris, Giuseppe; Sciot, Raf; Wozniak, Agnieszka; Van Looy, Thomas; Wellens, Jasmien; Faa, Gavino; Normant, Emmanuel; Debiec-Rychter, Maria; Schöffski, Patrick

    2011-09-01

    KIT activity is crucial for gastrointestinal stromal tumors (GIST). Imatinib (IMA) and sunitinib (SUN) are very effective KIT-inhibitors in patients with advanced GIST but have no curative potential. We evaluated the efficacy of the novel HSP90 inhibitor IPI-493 alone, or in combination with IMA or SUN in GIST xenografts with KIT mutations. Nude mice (n = 98) were grafted bilaterally with human GIST carrying KIT exon 11 (GIST-PSW), KIT exon 9 (GIST-BOE), or double, KIT imatinib-sensitive exon 11 and imatinib-resistant exon 17 mutations (GIST-48). Mice were divided into six treatment groups and dosed orally for 15 days as follows: (i) control group, sterile water; (ii) IMA alone; (iii) SUN alone; (iv) IPI-493 alone; (v) IPI-493+IMA; and (vi) IPI-493+SUN. Treatment with IPI-493 resulted in tumor growth stabilization, variable proliferation arrest, induction of apoptosis and necrosis, and downregulation of KIT and its signaling cascade, especially in the GIST-BOE model. Significant reduction of vessel density was observed with IPI-493 treatment, and was equal to SUN treatment in GIST-PSW and GIST-BOE xenografts. IPI-493 treatment effects were enhanced in combination with TKIs, especially with IPI-493+SUN. In our hands, IPI-493 showed dose-dependent liver damages. When administered as a single agent in a xenograft model, the HSP90 inhibitor IPI-493 has consistent antitumor activity and induces KIT downregulation in GISTs with heterogeneous KIT mutations. IPI-493 synergizes with TKIs that are commonly used for the treatment of advanced or IMA-resistant GIST. The antitumor response of IPI-493 is particularly enhanced in combination with SUN. ©2011 AACR.

  17. File Sharing, Napster, and Institutional Responses: Educative, Developmental, or Responsive Policy?

    Science.gov (United States)

    Lane, Jason E.; Healy, Margaret A.

    2005-01-01

    Student use of the Internet for such purposes as sharing and downloading illegal copies of music and movies presents new and complex challenges in the relationship between the institution and student. This article reviews the development of the file sharing phenomena; and through analysis of existing institutional responses, legal advice, media…

  18. Higher Education Institutions and the Administration of International Student Rights: A Law and Policy Analysis

    Science.gov (United States)

    Ramia, Gaby

    2017-01-01

    The scholarly literature in higher education has not dealt extensively with the responsibilities of institutions for servicing the rights of international students. This paper is a comparative analysis of legal frameworks which guide institutions in their handling of international student rights. Two national approaches, those of Australia and New…

  19. Comparison of Conventional Prognostic Indices in Patients Older than 60 Years with Diffuse Large B-Cell Lymphoma Treated with R-CHOP in the US Intergroup Study (ECOG 4494, CALGB 9793): Consideration of Age Greater than 70 Years in an Elderly Prognostic Index (E-IPI)

    OpenAIRE

    Advani, R.H.; Chen, H.; Habermann, T.M; Morrison, V.A.; Weller, E.A.; Fisher, R.I.; Peterson, B. A.; Gascoyne, R.D.; Horning, S.J.

    2010-01-01

    To assess if immunochemotherapy influenced the prognostic value of IPI in elderly diffuse large B-cell lymphoma (DLBCL) patients, we evaluated the performance of the standard International Prognostic Index (IPI) and following modifications: age adjusted (AA)-IPI, revised (R)-IPI, and an elderly IPI with age cut-off 70 years (E-IPI) in patients >60 years treated with RCHOP (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone). In 267 patients, by IPI/AA-IPI 60% were high-inter...

  20. Institutional statism: an overview of the formulation of the taxi recapitalisation policy

    Directory of Open Access Journals (Sweden)

    D. van Schalkwyk

    2008-07-01

    Full Text Available This article provides an overview of the government’s formulation of the taxi recapitalisation policy which is aimed at regulating the minibus taxi industry. Coupled with a brief social and politico-historical context of the policy, the aim is to highlight the government’s statist conduct in the formulation of the recapitalisation policy. The minibus taxi industry started to fulfil a prominent role in the 1970s as a result of a loophole in the legislation of the former apartheid government. It is currently the most accessible mode of public transport and conveys 65 per cent of the country’s commuters daily. Consequently, the Industry is an imperative force to be considered by the government in its formulation of transport policies. However, the industry is characterised by numerous problems, including a high rate of minibus taxis involved in accidents, unroadworthy vehicles and violence. It is in this context that the government formulated both the original and revised versions of the recapitalisation policy. However, the formulation of the policy has been problematic. The government followed a statist approach during the formulation process when it directed the course of the process according to its interests and without adequate consultation with relevant role players.

  1. Institutional barriers to a ‘perfect’ policy: A case study of the Senegalese Rural Electrification Plan

    International Nuclear Information System (INIS)

    Mawhood, Rebecca; Gross, Robert

    2014-01-01

    This paper investigates the political and institutional factors that have influenced the success of the Senegalese Rural Electrification Action Plan (Plan d'Action Sénégalais d'Électrification Rurale, PASER). PASER is of interest because its innovative design attracted extensive offers of finance from donors and independent power providers, however it has had limited effect on electrification levels. This paper examines PASER's progress and problems in detail, with the aim of informing rural electrification policy internationally. An extensive literature review was combined with 26 semi-structured stakeholder interviews, to produce a snapshot of the Plan's status after its first decade of operation. PASER's experiences are compared with other reform-based rural electrification initiatives across Sub-Saharan Africa. PASER has faced significant institutional and political barriers, with delays arising from organisational opposition, inconsistent ministerial support, protracted consultations and the inherent challenges of implementing an innovative policy framework in a country with limited institutional capacity. The development of human and institutional capacity has been compromised by inconsistent political commitment. Such experiences mirror those of electrification initiatives across Sub-Saharan Africa. Whilst PASER's successes in garnering external support and fundraising are noteworthy and won praise from early reviews, in terms of delivery the Plan has failed to resolve common institutional barriers. - Highlights: • Factors influencing the Senegalese Rural Electrification Action Plan are investigated. • 26 Stakeholder interviews inform a review of the Plan after 10 years of operation. • The Plan has attracted extensive finance, but installations are severely delayed. • The delays are found to be largely the result of institutional and political barriers. • These barriers mirror the experiences of electrification

  2. Antitumor activity of the Hsp90 inhibitor IPI-504 in HER2-positive trastuzumab-resistant breast cancer.

    Science.gov (United States)

    Scaltriti, Maurizio; Serra, Violeta; Normant, Emmanuel; Guzman, Marta; Rodriguez, Olga; Lim, Alice R; Slocum, Kelly L; West, Kip A; Rodriguez, Varenka; Prudkin, Ludmila; Jimenez, José; Aura, Claudia; Baselga, José

    2011-05-01

    Hsp90 facilitates the maturation and stability of numerous oncoproteins, including HER2. The aim of this study was to assess the antitumor activity of the Hsp90 inhibitor IPI-504 in trastuzumab-resistant, HER2-overexpressing breast cancer cells. Therapy with trastuzumab, IPI-504, and the combination of trastuzumab and IPI-504 was evaluated in trastuzumab-sensitive and trastuzumab-resistant cells. Inhibition of protein targets, cell proliferation, and tumor growth was assessed in vitro and in xenograft models. IPI-504 inhibited proliferation of both trastuzumab-sensitive and trastuzumab-resistant cells. Administration of IPI-504 markedly reduced total levels of HER2 and Akt, as well as phosphorylated Akt and mitogen-activated protein kinase (MAPK), to an equal extent in trastuzumab-sensitive and trastuzumab-resistant cells. IPI-504, used as single agent or in combination with trastuzumab, also inhibited in vivo the growth of both trastuzumab-sensitive and -resistant tumor xenografts. As a mechanism for the observed antitumor activity, IPI-504 resulted in a marked decrease in the levels of HER2, Akt, p-Akt, and p-MAPK in trastuzumab-resistant xenografts as early as 12 hours after a single dose of IPI-504. IPI-504-mediated Hsp90 inhibition may represent a novel therapeutic approach in trastuzumab refractory HER2-positive breast cancer.

  3. Arthroscopic treatment of iliopsoas impingement (IPI) after total hip replacement.

    Science.gov (United States)

    Jerosch, Jorg; Neuhäuser, Christian; Sokkar, Sherif M

    2013-10-01

    The purpose of the study was to present our arthroscopic surgical technique and the results in patient with an iliopsoas impingement (IPI) syndrome after a hip replacement. Between 1999 and 2011, 35 patients with the clinical picture of an IPI after total hip replacement were diagnosed and treated arthroscopically. The age was ranged from 58 to 82 years. All patients underwent conservative treatment for at least 6 months without success. The indication for the arthroscopic procedure was the failure of the conservative therapy as well as typical clinical signs as painful hip flexion, a positive local anesthesia test and radiological evidence of the presence of a prominent anterior acetabular component. The arthroscopic treatment was performed in all patients with anterior capsulotomy and partial capsulectomy of the hip joint. After identification of the pathology an arthroscopic release of the iliopsoas tendon in the region of the proved lesion was performed. The average follow-up period was 3.6 years (6 months to 12 years). In all patients osseous integrated acetabular components were found. In six cases there was a surface replacement, in three cases it was a cementless screw-in cup and in the other three cases it was a cementless modular press-fit cup. 8 out of 12 patients suffered from a hip dysplasia with a secondary osteoarthritis. After establishing an anterior capsular window arthroscopically, the iliopsoas tendon could be visualized in all cases. In addition to multiple local tendinitis all patients already showed mechanical limitation with partial rupture of variable extent in the iliopsoas tendon. During the arthroscopy the lesion was detected at the level of the anterior prominent acetabular component as well as distal to it. 10 out of 12 patients reported immediately after postoperative mobilization that the typical preoperative complaints have disappeared. Two patients still had residual pain. In one of those patients this was relieved by the time

  4. Evaluation of clinical and biological prognostic factors in relapsed or refractory diffuse large B-cell lymphoma patients after previous treatment with rituximab and chemotherapy: results of the PRO-R-IPI study.

    Science.gov (United States)

    Panizo, Carlos; Rodríguez, Anny Jaramillo; Gutiérrez, Gonzalo; Díaz, Francisco Javier; González-Barca, Eva; de Oña, Raquel; Grande, Carlos; Sancho, Juan Manuel; García-Álvarez, María Flor; Sánchez-González, Blanca; Peñalver, Francisco Javier; Cannata, Jimena; Espeso, Manuel; Requena, María José; Gardella, Santiago; Durán, Soledad; González, Ana Pilar; Alfonso, Ana; Caballero, María Dolores

    2015-07-01

    Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous entity, showing a highly variable outcome. In patients with DLBCL relapsed/refractory to first-line treatment with rituximab the usefulness of the revised International Prognostic Index (R-IPI) as a prognostic tool remains unexplored. Some biological parameters (B-cell lymphoma 6 [Bcl-6], Bcl-2, p53, and multiple myeloma 1 [MUM1]) and blood populations (lymphocyte and monocyte counts) have been described as International Prognostic Index-independent prognostic factors. The objective was to evaluate the R-IPI to predict the outcome of DLBCL patients at the time of relapse after a front-line treatment with chemotherapy and rituximab and to establish in this population the relationship between biological parameters and outcome. We included patients with refractory/relapsed DLBCL after first-line treatment with rituximab-containing regimens; patients must have already finished a rescue treatment also including rituximab. Immunohistochemical assessment of Bcl-2, Bcl-6, p53, and MUM1 expression were undertaken in available biopsies. R-IPI factors were identified from the clinical data at diagnosis and at relapse. Response was assessed using National Cancer Institute-sponsored Working Group guidelines. R-IPI prognosis at relapse was not significantly associated with overall response rate (ORR) after Rituximab-chemotherapy rescue therapy. None of the immunohistochemical parameters analyzed correlated with rescue therapy results. In contrast, patients with absolute lymphocyte count (ALC) ≥ 1 × 10(9)/L at relapse were more likely to respond than patients with ALC IPI score calculated at relapse could not predict the ORR to second-line treatment. Lymphopenia is a simple and useful predictor for outcome in relapsed/refractory DLBCL and the only prognostic factor that in our hands could predict the overall response to a second-line treatment with rituximab and chemotherapy. Copyright © 2015 Elsevier Inc. All rights

  5. Crossing institutional boundaries: mapping the policy process for improved control of endemic and neglected zoonoses in sub-Saharan Africa.

    Science.gov (United States)

    Okello, Anna; Welburn, Susan; Smith, James

    2015-07-01

    The recent adoption of the World Health Assembly Resolution 66.12 for neglected tropical diseases (NTDs) in May 2013 is an important turning point for advocacy regarding a number of endemic zoonotic infections, defined by the World Health Organization as the neglected zoonotic diseases (NZDs). In addition to NTD-listed zoonoses such as rabies, echinococcosis (hydatid disease), leishmaniasis, Human African trypanosomiasis (sleeping sickness) and Taenia solium cysticercosis, the NZDs also include important bacterial zoonoses such as anthrax, bovine tuberculosis and brucellosis. To date, analysis of the processes that prioritize, develop and deliver zoonoses control programmes in many low- and middle-income countries is lacking, despite its potential to highlight significant evidence gaps and institutional constraints to the intersectoral approach required for their control. Policy process analysis was conducted via a series of semi-structured interviews with key policy actors within various ministries and institutes in Uganda and Nigeria. The study concluded that despite the rhetoric around 'linear' models of health policy development promoting consultation with a wide range of national stakeholders, the decision-making process for zoonotic disease control appears instead overtly influenced by the external political economy of trending pandemic threats, often overlooking national and regional zoonoses priorities. The inclusion of political systems remains a key factor in the zoonoses analysis matrix, enhancing our understanding of the intersectoral and transdisciplinary approaches required for their control. The authors consider policy process analysis to be a fundamental first step of any attempt to holistically strengthen human and animal health systems in a development context, particularly regarding the promotion of integrated control policies for regionally important zoonoses under the growing One Health movement. Published by Oxford University Press in

  6. Impact of the Smoothened inhibitor, IPI-926, on smoothened ciliary localization and Hedgehog pathway activity.

    Science.gov (United States)

    Peluso, Marisa O; Campbell, Veronica T; Harari, Joseph A; Tibbitts, Thomas T; Proctor, Jennifer L; Whitebread, Nigel; Conley, James M; White, Kerry F; Kutok, Jeffery L; Read, Margaret A; McGovern, Karen; Faia, Kerrie L

    2014-01-01

    A requisite step for canonical Hedgehog (Hh) pathway activation by Sonic Hedgehog (Shh) ligand is accumulation of Smoothened (Smo) to the primary cilium (PC). Activation of the Hh pathway has been implicated in a broad range of cancers, and several Smo antagonists are being assessed clinically, one of which is approved for the treatment of advanced basal cell carcinoma. Recent reports demonstrate that various Smo antagonists differentially impact Smo localization to the PC while still exerting inhibitory activity. In contrast to other synthetic small molecule Smo antagonists, the natural product cyclopamine binds to and promotes ciliary accumulation of Smo and "primes" cells for Hh pathway hyper-responsiveness after compound withdrawal. We compared the properties of IPI-926, a semi-synthetic cyclopamine analog, to cyclopamine with regard to potency, ciliary Smo accumulation, and Hh pathway activity after compound withdrawal. Like cyclopamine, IPI-926 promoted accumulation of Smo to the PC. However, in contrast to cyclopamine, IPI-926 treatment did not prime cells for hyper-responsiveness to Shh stimulation after compound withdrawal, but instead demonstrated continuous inhibition of signaling. By comparing the levels of drug-induced ciliary Smo accumulation with the degree of Hh pathway activity after compound withdrawal, we propose that a critical threshold of ciliary Smo is necessary for "priming" activity to occur. This "priming" appears achievable with cyclopamine, but not IPI-926, and is cell-line dependent. Additionally, IPI-926 activity was evaluated in a murine tumor xenograft model and a pharmacokinetic/pharmacodynamic relationship was examined to assess for in vivo evidence of Hh pathway hyper-responsiveness. Plasma concentrations of IPI-926 correlated with the degree and duration of Hh pathway suppression, and pathway activity did not exceed baseline levels out to 96 hours post dose. The overall findings suggest that IPI-926 possesses unique biophysical

  7. IPY 2007-2008 data legacy - a ong story cut short

    Science.gov (United States)

    Driemel, A.; Grobe, H.; Diepenbroek, M.; Grüttemeier, H.; Schumacher, S.; Sieger, R.

    2015-06-01

    The International Polar Year 2007-2008 was a synchronized effort to simultaneously collect data from polar regions. Being the fourth in a row of IPYs, the demand for interdisciplinarity and new data products was high. However, despite of all the research done on land, people, ocean, ice and atmosphere and the large amount of data collected, no central archive or portal was created for IPY data. In order to address these issues, a concerted effort between PANGAEA - Data Publisher for Earth and Environmental Science, the ICSU World Data System (WDS), and the International Council for Scientific and Technical Information (ICSTI) was undertaken to extract data resulting from IPY publications for long-term preservation. 1380 IPY-related references were collected. Out of these, only 450 contained accessible data. All data was extracted, quality checked, annotated with metadata and uploaded to PANGAEA. The 450 articles dealt with a multitude of IPY topics - plankton biomass, water chemistry, ice thickness, whale sightings, Inuit health, alien species introductions by travelers or tundra biomass change - to mention just a few. Both, the Arctic and the Antarctic were investigated in the articles, and all realms (land, people, ocean, ice and atmosphere) and a wide range of countries were covered. The data compilation can now be found with the identifier doi:10.1594/PANGAEA.150150 and individually searched for using the PANGAEA search engine (www.pangaea.de) and adding "+project:ipy". With this effort, we hope to improve the visibility, accessibility and long-term storage of IPY data for future research and new data products.

  8. Issues and considerations on the development of an institutional controls policy for uranium mines within Northern Saskatchewan

    International Nuclear Information System (INIS)

    Sigurdson, B.E.; Bilokury, M.R.; Snider, R.C.

    2002-01-01

    Institutional control of a mine site is required to ensure long-term public safety and environmental protection once responsibility for a decommissioned uranium mine site reverts back to the Crown. During the exploration, development, operation and decommissioning phases of a uranium mine's life cycle, public safety and environmental protection are ensured through the Federal and Provincial Environmental Assessment Review process, regulatory permitting and compliance monitoring by the province. However, at present, there is no clear provincial policy with respect to a proponent's application for release from a reclaimed and decommissioned site, and the resulting provincial responsibility for the long-term management and maintenance of the site once a release has been granted. Another policy issue has been identified with respect to the long-term institutional control of previously abandoned uranium mine sites. A number of issues are being considered by the Government of Saskatchewan in developing a policy which addresses the needs of the people of Saskatchewan and which is consistent with the intent of the commitments made by Canada through its ratification of the International Atomic Energy Agency's (IAEA) Joint Convention on the Safety of Spent Fuel Management and on the Safety of Radioactive Waste Management. (author)

  9. Institutional Transition from Welfare Enterprise to Social Enterprise: the Localization of Legislation and Policy in Chinese Context

    Directory of Open Access Journals (Sweden)

    Zhang Xiaomeng

    2016-03-01

    Full Text Available Welfare enterprises, which are intended to create jobs for disabled people, are the core component of China's welfare system. As the economic environment and regulations change, China's welfare enterprises, which cannot take effective measures from within and emerge strong in market competition, are stuck in a bottleneck where further development is difficult. Welfare enterprises have hit the ceiling in their development for lacking sustainable sources of capital and capabilities of capital operation, inefficient management model and uncompetitive products and services. To reverse the trend of decline and grow into strong market players, the transformation from welfare enterprise to social enterprise, embracing the features of enterprise and social objectives, as an alternative is of crucial importance. As a new hybrid economic form, social enterprise combines the efficiency of businesses and the public-good nature of welfare enterprises, representing win-win cooperation among the government, society, and business sector. Such development is an institutional transformation which boosts competitiveness and tackles tough issues welfare enterprises are facing. Shifting from welfare enterprises to social enterprises means an institutional transition, during the process of which international experience in legislation shall be learned and localized. This paper analyzes the development history of welfare enterprises by taking a comprehensive look at the salient points of existing laws, policies promulgated throughout history, implementation and performance, major problems etc. so as to explore the institutional transition from welfare enterprises to social enterprises, revealing possible legal and policy problems and making suggestions.

  10. The impacts of implementation of National Essential Medicines Policies on primary healthcare institutions: a cross-sectional study in China

    Directory of Open Access Journals (Sweden)

    Zhigang Guo

    2017-11-01

    Full Text Available Abstract Background In 2009, China implemented the National Essential Medicines Policies (NEMPs as part of a new round of medical system reforms. This study aims to evaluate the impacts of the NEMPs on primary healthcare institutions and discuss the roles of the policies in the new healthcare reforms of China. Methods The study selected a total of six representative provinces of China, generating a sample of 261 primary healthcare institutions from August to December in 2010. A questionnaire survey developed by the study team was distributed to all of the primary healthcare institutions. Nine indicators from three dimensions as the outcome variables were used and calculated to evaluate the impacts of implementation of policies. All of the outcome variables were tested using independent-samples T test between the treatment group (with the NEMPs implemented and the control group (without the NEMPs implemented. Results The ratio of drug sales and institution revenues at primary healthcare institutions was 42.99% in the treatment group, which was significantly lower than the control group (53.90%, p < 0.01, while the ratio of financial subsidies of the treatment group was shown to be higher (30.78% VS 20.82%, p < 0.01. The rate of healthcare workers income growth was greater in the treatment group (15.35% VS 5.79%, p = 0.006. The treatment group exhibited higher outpatient and emergency visits per month in urban areas (2720 VS 1763 visits per month and rural areas (3830 VS 3633, and higher prescriptions per month in urban areas (2048 VS 1025, p = 0.005 and rural areas (3806 VS 3251. The treatment group used more essential medicines and received greater income from essential medicines while the drug price markup rate was lower. Conclusions The NEMPs appear to affect the transformation of the operation mechanisms of primary healthcare institutions, the improvement of the mechanisms for government investment, and the healthcare pricing

  11. ICT Policies and Strategies in Higher Education in South Africa: National and Institutional Pathways

    Science.gov (United States)

    Cross, Michael; Adam, Fatima

    2007-01-01

    This paper focuses on policy initiatives and strategies used to promote the use of information and communication technologies (ICTs) in higher education in South Africa. It explores a wider international outlook and current debates in South Africa to map out an emerging South African perspective concerning the integration of ICT in higher…

  12. An institutional framework for designing and monitoring ecosystem-based fisheries management policy experiments

    NARCIS (Netherlands)

    Rudd, M.A.

    2004-01-01

    Indicator systems are seen as central tools for ecosystem-based fisheries management, helping to steer fisheries towards sustainability by providing timely and useful information to decision-makers. Without testing hypotheses about the links between policies and outcomes, however, indicator systems

  13. Preliminary Country Reports on Feasibility Survey: Policy Research and Education Institutions for Developing Countries.

    Science.gov (United States)

    Mitchell, James M.; Luikart, F. W.

    The feasibility of creating independent research and education centers that deal with public policy issues in developing countries is assessed. Countries that were surveyed include Brazil, Colombia, Bolivia, Costa Rica, Guatemala, South Korea, Philippines, Pakistan, and Nepal. For each country, a report describes the social and political climate…

  14. Ideational Leadership in German Welfare State Reform. How Politicians and Policy Ideas Transform Resilient Institutions

    NARCIS (Netherlands)

    Stiller, S.J.

    2010-01-01

    editors of the series Gøsta Esping-Andersen, University of Pompeu Fabra, Barcelona, Spain Anton Hemerijck, the Netherlands Scientific Council for Government Policy (Wetenschappelijke Raad voor het Regeringsbeleid - wrr) Kees van Kersbergen, Free University Amsterdam, the Netherlands Kimberly Morgan,

  15. Multi-Level Steering and Institution Building: The European Union's Approach to Research Policy

    Science.gov (United States)

    Young, Mitchell

    2012-01-01

    Adopting the conception of the university as a primary driver of innovation and economic growth has brought increased pressure for the European Union (EU) to actively steer university-based research policy, despite its being outside of the EU's direct jurisdiction. While the open method of coordination (OMC) was developed for such situations, the…

  16. Sermons, Carrots or Sticks? Explaining Successful Policy Implementation in a Low Performance Institution

    Science.gov (United States)

    Salazar-Morales, Diego Alonso

    2018-01-01

    This article explains how after 43 years of unsatisfactory outcomes, the Ministry of Education of Peru (MoE) suddenly ranked at the top of governmental performance tables. To do so, this study relies on implementation and major discussions of policy instrument theories to provide a comprehensive explanation of the reasons underlying the MoE's…

  17. Participatory technology, policy and institutional development to address soil fertility degradation in Africa

    NARCIS (Netherlands)

    Jager, de A.

    2005-01-01

    At global scale nutrient flows are unbalanced, resulting in huge surpluses in Western Europe versus negative balances in Africa. Existing policy and socio-economic environments in different parts of the world are the major cause of this situation. At lower spatial scales, a much more complex and

  18. Pension Fund Restoration Policy in General Equilibrium : Tinbergen Institute MPhil Thesis

    NARCIS (Netherlands)

    Kastelein, P.

    2016-01-01

    This paper quantifies the business cycle effects and distributional implications of pension fund restoration policy after the economy has been hit by a financial shock. We extend a canonical New-Keynesian dynamic general equilibrium model with a tractable demographic structure and a pension fund.

  19. The National Energy Policy Institute (NEPI) at The University of Tulsa (F INAL REPORT)

    Energy Technology Data Exchange (ETDEWEB)

    Blais, Roger [Univ. of Tulsa, OK (United States)

    2013-10-31

    NEPI, a non-profit organization located at The University of Tulsa (TU), was established to develop and disseminate national energy policy recommendations. Research under this grant covered a wide variety of projects, including research into the future of nuclear power, oil market pricing, and the feasibility of biofuels.

  20. Overview of National Policy Contexts for Entrepreneurialism in Higher Education Institutions

    Science.gov (United States)

    Williams, Gareth; Kitaev, Igor

    2005-01-01

    This paper is based on seven national reports on national policies concerned with entrepreneurialism in universities as the context for a more detailed study of entrepreneurial behaviour in universities in the seven countries. It claims that the entrepreneurial university is a useful generic epithet to describe the manifold changes in mission,…

  1. Policies, Socioeconomic, Institutional and Biophysical Factors Influencing the Change from Rice to Sugarcane in Nong Bua Lamphu Province, Thailand

    Science.gov (United States)

    Lakapunrat, Narinpat; Thapa, Gopal B.

    2017-06-01

    For the past decade, Thailand pursued a strategy of promoting biofuel crop production, including sugarcane, to meet the ever increasing energy demand and to increase the income of farmers. This study analyzed the influence of policy instruments implemented to promote the sugarcane cultivation, farm household socioeconomic levels, biophysical, and institutional factors driving the conversion of rice fields into sugarcane farms. Primary information was collected from 230 farm households through a structured questionnaire. Relevant policy documents published by the responsible government agencies were the main sources of secondary information collected for policy analysis. The analyses revealed that farmers in the study area converted 25-75% of their rice fields into sugarcane farms as a result of implementation of policy instruments that made sugarcane financially far more attractive than rice. The results of the regression analysis showed that eight variables were found significant and positively influenced the conversion of rice fields into sugarcane farms. These were access to extension services, information, sugarcane loading stations, and ground water for irrigation, and duration of experience in sugarcane farming as well as household head's age and education. Irrespective of landholding size, the majority of farmers were not concerned about food security. In view of the finding, if feasible, in the form of additional price supports and commercial cane sugar index-based pricing strategies to promote sugarcane production should benefit all concerned farmers. Likewise, attention should be paid to deliver essential extension and marketing services in an effective way, particularly to those farmers who are not receiving such services.

  2. 機構典藏相關政策之探討 A Study on Relevant Policies for Institutional Repositories

    Directory of Open Access Journals (Sweden)

    Ching-Chun Lo

    2005-12-01

    Full Text Available 本研究旨在探討制定機構典藏政策的相關議題,藉由文獻探討瞭解國際之研究與發展現況,並透過內容分析法分析國外54所大學所制定之機構典藏政策內容,據以製作問卷,於訪談國內12所大學圖書館同時進行調查,期能瞭解國內大學對典藏政策制定之相關意見,並根據調查與研究結果,對國內未來發展機構典藏及制定政策提出結論與建議。This research aims to investigate the relevant policies for Institutional Repositories (IRs. According to literature review, the international research and development are also investigated. In addition, by utilizing content analysis method, 54 foreign universities are studied for their policies of IRs. Simultaneous questionnaire survey and interview are conducted with 12 university libraries in Taiwan, to better understand the recent development of IRs, and to get some feedback on the policy issues. Finally, according to these results, conclusion and suggestion are made for the future development and relevant policies for IRs.

  3. The recent institutional history of cultural heritage policy in the city of Rio de Janeiro: protectionist versions, entrepreneurial versions.

    Directory of Open Access Journals (Sweden)

    João Luiz Domingues

    2016-09-01

    Full Text Available This article aims to present the relations between the new urban management and the cultural heritage. The recent history of the current heritage policies of the city of Rio de Janeiro will be objectively analyzed and such will be illustrated in two different phases. The first one shows the choices made by the institutions that protect the national memory, which emphasize concern with the urban and landscape ensemble sphere, including preliminary articulation with the environmental sphere. In a second, more recent phase, the heritage policies embody elements from urban marketing and creative economy, becoming notoriously close to urban entrepreneurship, and making the bureaucratic centralism scenario, which was already building up, its final effort. It is aimed to put that the current changes in the form of representation and action on the urban, which contribute to the radicalization of the city mercantilization process, find clear support in the cultural field, especially when it comes to its management.

  4. Institutional Framework for Economic Re-Industrialization in the Mechanism of Industrial Policy Realization

    Directory of Open Access Journals (Sweden)

    Alexandra S. Shitova

    2017-09-01

    Full Text Available An attempt has been made to substantiate the institutional structure aimed at the effective progressive development of the production sphere as the basis of the national economy oriented towards the qualitative development of social capital, which is the key goal of transforming the modern Russian economy. The achievement of that goal is possible through the implementation of reindustrialization strategy based on the conceptual platform of regional institutionalism, the determinant of which is also the possibility of implementing the potential of the regions as a priority source of development and reproduction as a result of building sustainable local relationships in the regional economy. Institutional design of reindustrialization and forcing the industrial development of the Russian economy are becoming particularly relevant in the context of the need to connect Russia to the concept of "Industry 4.0" and the fourth industrial revolution.

  5. Managing vulnerability to drought and enhancing livelihood resilience in sub-Saharan Africa: Technological, institutional and policy options

    Directory of Open Access Journals (Sweden)

    Bekele Shiferaw

    2014-06-01

    Full Text Available Agriculture and the economies of Sub-Saharan Africa (SSA are highly sensitive to climatic variability. Drought, in particular, represents one of the most important natural factors contributing to malnutrition and famine in many parts of the region. The overall impact of drought on a given country/region and its ability to recover from the resulting social, economic and environmental impacts depends on several factors. The economic, social and environmental impacts of drought are huge in SSA and the national costs and losses incurred threaten to undermine the wider economic and development gains made in the last few decades in the region. There is an urgent need to reduce the vulnerability of countries to climate variability and to the threats posed by climate change. This paper attempts to highlight the challenges of drought in SSA and reviews the current drought risk management strategies, especially the promising technological and policy options for managing drought risks to protect livelihoods and reduce vulnerability. The review suggests the possibilities of several ex ante and ex post drought management strategies in SSA although their effectiveness depends on agro-climatic and socio-economic conditions. Existing technological, policy and institutional risk management measures need to be strengthened and integrated to manage drought ex ante and to minimize the ex post negative effects for vulnerable households and regions. A proactive approach that combines promising technological, institutional and policy solutions to manage the risks within vulnerable communities implemented by institutions operating at different levels (community, sub-national, and national is considered to be the way forward for managing drought and climate variability.

  6. Commentary: More implications of the 2008 amendments to the Americans with Disabilities Act: influencing institutional policies, practices, and procedures.

    Science.gov (United States)

    DeLisa, Joel; Silverstein, Robert; Thomas, Peter

    2011-06-01

    The Americans with Disabilities Act (ADA) is a civil rights law designed to ensure that qualified individuals with disabilities are not discriminated against by covered entities. Under the ADA, colleges of medicine were expected to focus their attention on implementing policies that facilitated equal educational opportunity, not on the threshold question of whether an individual was considered "disabled enough" to be protected by the law. In this issue, Allen and Smith examine the implications of the 2008 ADA Amendments Act (ADAAA) for medical education, focusing on the potential for the ADAAA to eliminate the threshold question and allow individuals seeking protection to bring their cases to trial.The authors of this commentary argue that the ADAAA also has important implications for institutions like colleges of medicine and the National Board of Medical Examiners that must not be overlooked. The impact of the ADAAA on colleges of medicine will depend in large part on how they historically viewed their obligations under the ADA. Those institutions that focused on eliminating all vestiges of disability discrimination by implementing comprehensive, system-wide, evidence-based policies, practices, and procedures related to reasonable accommodations and academic modifications/adjustments will experience little or no impact under the ADAAA. Those colleges that attempted to avoid or minimize compliance with the ADA by focusing on whether an individual achieved sufficient disability status to be protected by the law will need to pay closer attention to the development and implementation of nondiscrimination policies, particularly policies relating to reasonable accommodations and academic modifications/adjustments.

  7. IPI-145 antagonizes intrinsic and extrinsic survival signals in chronic lymphocytic leukemia cells.

    Science.gov (United States)

    Dong, Shuai; Guinn, Daphne; Dubovsky, Jason A; Zhong, Yiming; Lehman, Amy; Kutok, Jeffery; Woyach, Jennifer A; Byrd, John C; Johnson, Amy J

    2014-12-04

    Chronic lymphocytic leukemia (CLL) displays constitutive phosphatidylinositol 3-kinase (PI3K) activation resulting from aberrant regulation of B-cell receptor (BCR) signaling. Previous studies have shown that an oral PI3K p110δ inhibitor idelalisib exhibits promising activity in CLL. Here, we demonstrate that a dual PI3K p110δ and p110γ inhibitor, IPI-145, antagonizes BCR crosslinking activated prosurvival signals in primary CLL cells. IPI-145 causes direct killing in primary CLL cells in a dose- and time-dependent fashion, but does not generate direct cytotoxicity to normal B cells. However, IPI-145 does reduce the viability of normal T and natural killer cells and decrease activated T-cell production of various inflammatory and antiapoptotic cytokines. Furthermore, IPI-145 overcomes the ibrutinib resistance resulting from treatment-induced BTK C481S mutation. Collectively, these studies provide rationale for ongoing clinical evaluation of IPI-145 as a targeted therapy for CLL and related B-cell lymphoproliferative disorders. © 2014 by The American Society of Hematology.

  8. Education for Public Policy and Management: Views from the Institute of Social Studies, The Hague

    NARCIS (Netherlands)

    D.R. Gasper (Des); J.W. Björkman (James Warner); V. Moharir (Vasant); M.E. Wuyts (Marc)

    2000-01-01

    markdownabstractIntroduction When the Institute of Social Studies, ISS, was founded in 1952 in The Hague as a postgraduate centre for teaching and research on social and economic development, it established the first Masters programme in public administration and the first professorial chair in

  9. 77 FR 37399 - Policy Statement Concerning Assistance to Troubled Farm Credit System Institutions

    Science.gov (United States)

    2012-06-21

    ... present-value analysis of the troubled System institution's assets, using a reasonable discount rate. As... information, the Corporation must: (1) Evaluate alternatives on a present-value basis, using a reasonable...) Evaluate alternatives on a present-value basis, using a reasonable discount rate, (2) document the...

  10. Economic and policy factors driving adoption of institutional woody biomass heating systems in the United States

    Science.gov (United States)

    Jesse D. Young; Nathaniel M. Anderson; Helen T. Naughton; Katrina Mullan

    2018-01-01

    Abundant stocks of woody biomass that are associated with active forest management can be used as fuel for bioenergy in many applications. Though factors driving large-scale biomass use in industrial settings have been studied extensively, small-scale biomass combustion systems commonly used by institutions for heating have received less attention. A zero inflated...

  11. Practical steps toward integrating economic, social and institutional elements in fisheries policy and management

    NARCIS (Netherlands)

    Stephenson, Robert L.; Benson, Ashleen J.; Brooks, Kate; Charles, Anthony; Degnbol, Poul; Dichmont, Catherine M.; Kraan, Marloes; Pascoe, Sean; Paul, Stacey D.; Rindorf, Anna; Wiber, Melanie

    2017-01-01

    While international agreements and legislation call for incorporation of four pillars of sustainability, the social (including cultural), economic and institutional aspects (the ‘human dimension’) have been relatively neglected to date. Three key impediments have been identified: a relative lack of

  12. Cyber-Harassment in Higher Education: A Study of Institutional Policies and Procedures

    Science.gov (United States)

    Schaefer-Ramirez, Victoria Ann

    2017-01-01

    Cyberbullying is a growing phenomenon, causing concern among students, parents, and professionals in the educational community. Although no federal law specifically addresses cyber-harassment in higher education, institutions have a legal obligation to address all claims of harassment, regardless of the location or platform in which the harassing…

  13. Cost Containment for Higher Education: Strategies for Public Policy and Institutional Administration.

    Science.gov (United States)

    Simpson, William Brand

    This book discusses long term strategies for cost containment for higher education that are currently in use or could be employed. Some of the strategies discussed are applicable at various levels of government, some relate to interinstitutional arrangements and some are options of the individual institutions. The chapters are as follows: (1)…

  14. Energy policy in the Caribbean green economy context and the Institutional Analysis and Design (IAD) framework as a proposed tool for its development

    International Nuclear Information System (INIS)

    Shah, Kalim U.; Niles, Keron

    2016-01-01

    Market integration efforts of Caribbean small island developing states have become transposed on the growing paradigm shift towards green economy pathways. Central to this is the challenge of implementing Caribbean energy policy in a manner that is aligned with green economy ideals and face the realities of regional indebtedness and environmental impacts. Here we analyze the current state of the Caribbean energy policy development arena and propose that the currently weak policy and institutional design regime might potentially benefit from the application of the Institutional Analysis and Design (IAD) model especially within the operational context of the green economy. It allows us to identify current policy dilemmas, bottlenecks and discrepancies and to disentangle some of them while offering up a way forward with others. We do not so much offer distinct recommendations but focus more on delineating how to clear the pathway for sound policy intervention and outcomes. By doing so we set forth a challenging agenda for future policy analysis research that will advance Caribbean energy policy in more robust ways. - Highlights: • Un-coordinated Caricom energy policy can benefit from an institutional analysis and design approach. • Policy reform hinges on the patterns of interaction among key actors in the regional context. • Regional policy remains weak across efficiency, equity, accountability and adaptability parameters.

  15. The impact of political institution and structure on health policy making and implementation: Nigeria as a case study.

    Science.gov (United States)

    Adewole, D A

    2015-03-01

    Typical of the political structure of the United States of America, Nigeria operates a federal presidential system of government. Political power is shared between the three levels of Federal, State and the Local Governments. The political affairs of the country at these levels are determined by elected politicians from different political parties, with different political and developmental ideologies. This scenario has implications on policy making and implementation especially in the health sector. This paper sought to discuss the type of political structures and institutions and, the effect of these on health policy implementation in selected countries, with emphasis on Nigeria. CURRENT STATUS OF FINANCING HEALTH CARE: The National Health Insurance Scheme (NHIS) was launched almost a decade ago but currently covers an estimated four percent of the population, majority of which are in the formal sector. The poor coverage of the scheme in Nigeria has been attributed to the type of political institution and structure it operates. This is evident with examples of some countries in the world; whereas, the scheme in Nigeria was implemented almost at the same time like in neighbouring Ghana, the scheme in Ghana has made a considerable progress. Likewise, prepayment scheme for health in Britain has been in practice for decades, the U.S.A. is just currently making progress in the implementation of a nationwide prepayment scheme despite several years of efforts. It is important to note that Nigeria and the U.S.A. has similar political institution and structure different from what Ghana and Britain have in common. The current low level of coverage of the NHIS in Nigeria is largely due to the type of adopted political institution and structure. The implications of this on the health status of the people and national development cannot be overemphasized.

  16. THE TAX POLICY WITHIN THE EUROPEAN UNION: CONCEPTS, INSTITUTIONS, TRENDS AND CHALLENGES

    Directory of Open Access Journals (Sweden)

    CRISTINA COJOCARU (BOROVINA

    2016-06-01

    Full Text Available At the basis of conceiving the tax policy of an European Union member state, one must consider, on the one hand, fulfilling the government's own requirements, and on the other hand, achieving the objectives set by the EC Treaty. At present, the European Union has a quite harmonized and coordinated tax policy in the indirect taxes field, and partially in the direct taxes field, based on the free movement principle of goods, services, capital and labour; thus, although the member states have the freedom to set operation rules of their own national tax systems, this freedom is conditioned by the compliance with the priority objectives of the founding treaties of the European Union. The member states should avoid adopting discriminating tax measures (which could lead to a disadvantageous treatment for the persons, goods and services or capitals coming from other member states. Sometimes, the restrictions regarding free movement on the internal market are generated by the differences between the national tax systems, so that a certain degree of tax harmonization at the European Union level is necessary. The tax harmonization can be achieved either spontaneously (by means of the forces of the market, by means of active actions at the level of the European Union (the implementation of common policies, the coordination of the policies, the harmonization of the legislation, etc. or by means of the passive actions of the European Court of Justice (the interdiction of certain types of conduct of the member states that do not comply with the norms of the European Union. In the absence of the tax harmonization, negative effects can occur, such as: the erosion of the national tax bases, provision of public services and goods at a sub-optimal level, unwanted changes in the structure of the taxes which are levied in the member states, and distortions in assigning resources at the level of the single market.

  17. Institutional Policy Changes Aimed at Addressing Obesity Among Mental Health Clients

    OpenAIRE

    Knol, Linda L.; Pritchett, Kelly; Dunkin, Jeri

    2010-01-01

    Background People with mental illness often experience unique barriers to healthy eating and physical activity. For these clients, interventions should focus on changes in the immediate environment to change behaviors. The purpose of this project was to implement and evaluate policy changes that would limit calorie intake and increase calorie expenditure of clients receiving mental health services. Context This intervention was implemented in a rural mental health system in the southeastern U...

  18. Public Procurement as One of the Institutions of New Industrial Policy

    Directory of Open Access Journals (Sweden)

    Elena F. Gutselyuk

    2018-02-01

    Full Text Available The article shows the role of public procurement in the formation of the new economic policy. It is proved that the public procurement market is a source of in-vestment in the economy. Analyzed the role of certain prohibitions and restrictions on a policy of import substitution. The application of national treatment to limit the turnover of foreign products was used in the 19th century and is widely used in modern industrial policy, especially in the procurement of goods through the state and municipal budgets. In this regard, the article highlights some issues and ques-tions that arise in state and municipal customers in the provider definition, if a ban or restriction on the purchase of foreign products. Namely, denotes the problem of determining the country of origin of goods, especially when a normative act does not contain reference to any document. For example, procurement of certain medi-cal devices expressed concerns that certain restrictions on the purchase of foreign products can lead to the creation of artificial monopoly in the market, which in turn can lead to lower quality of goods. This article uses the normative legal acts adopted within the framework of national treatment as of December 2017.

  19. Financing institutional long-term care for the elderly in China: a policy evaluation of new models.

    Science.gov (United States)

    Yang, Wei; Jingwei He, Alex; Fang, Lijie; Mossialos, Elias

    2016-12-01

    A rapid ageing population coupled with changes in family structure has brought about profound implications to social policy in China. Although the past decade has seen a steady increase in public funding to long-term care (LTC), the narrow financing base and vast population have created significant unmet demand, calling for reforms in financing. This paper focuses on the financing of institutional LTC care by examining new models that have emerged from local policy experiments against two policy goals: equity and efficiency. Three emerging models are explored: Social Health Insurance (SHI) in Shanghai, LTC Nursing Insurance (LTCNI) in Qingdao and a means-tested model in Nanjing. A focused systematic narrative review of academic and grey literature is conducted to identify and assess these models, supplemented with qualitative interviews with government officials from relevant departments, care home staff and service users. This paper argues that, although SHI appears to be a convenient solution to fund LTC, this model has led to systematic bias in affordable access among participants of different insurance schemes, and has created a powerful incentive for the over-provision of unnecessary services. The means-tested method has been remarkably constrained by narrow eligibility and insufficiency of funding resources. The LTCNI model is by far the most desirable policy option among the three studied here, but the narrow definition of eligibility has substantively excluded a large proportion of elders in need from access to care, which needs to be addressed in future reforms. This paper proposes three lines of LTC financing reforms for policy-makers: (1) the establishment of a prepaid financing mechanism pooled specifically for LTC costs; (2) the incorporation of more stringent eligibility rules and needs assessment; and (3) reforming the dominant fee-for-service methods in paying LTC service providers. © The Author 2016. Published by Oxford University Press in

  20. The heat shock protein 90 inhibitor IPI-504 induces apoptosis of AKT-dependent diffuse large B-cell lymphomas.

    Science.gov (United States)

    Abramson, Jeremy S; Chen, Wen; Juszczynski, Przemyslaw; Takahashi, Hidenobu; Neuberg, Donna; Kutok, Jeffery L; Takeyama, Kunihiko; Shipp, Margaret A

    2009-02-01

    Heat shock protein 90 (HSP90) is a molecular chaperone that stabilizes critical client proteins in multiple cancers. Gene expression profiling was utilized to characterize HSP90 isoform expression in primary human diffuse large B-cell lymphomas (DLBCLs). HSP90 alpha and beta isoforms were differentially expressed in subsets of tumours defined by their transcriptional profiles. Thereafter, we assessed the activity of the HSP90 inhibitor, IPI-504, in an extensive panel of DLBCL cell lines. IPI-504, which interacts with the conserved ATP-binding site in both HSP90 isoforms, inhibited proliferation and induced apoptosis in the majority of DLBCL cell lines at low micromolar concentrations. IPI-504-sensitive cell lines expressed high levels of the HSP90 client protein, pAKT, and exhibited dose-dependent decreases in pAKT levels following IPI-504 treatment and significantly reduced proliferation following AKT RNAi. Furthermore, the combination of low-dose (IPI-504 and the AKT/Pi3K pathway inhibitor, LY24009, was synergistic in IPI-504-sensitive DLBCL cell lines. Low-dose IPI-504 was also synergistic with the chemotherapeutic agent, doxorubicin. The HSP90 inhibitor IPI-504 warrants further investigation in DLBCL alone and in combination with identified client protein inhibitors and active chemotherapeutic agents.

  1. Comparative Review of Selected Educational Policies of 1st and 2nd Cycle Institutions in Ghana and Burkina Faso, and That of United Kingdom and United States

    Science.gov (United States)

    Kumi, Asamoah Moses; Seidu, Abarichie Adamu

    2017-01-01

    This article examines some selected Educational Policies of First and Second Cycle Institutions in Ghana and Burkina Faso, in comparison with that of the UK and US. The purpose of the study is to itemise the commonalities and differences in Educational Policies of both developed (UK and US) and developing countries (Ghana and Burkina Faso) in…

  2. Features of state industrial policy under imperfect technological and institutional environment

    Directory of Open Access Journals (Sweden)

    Denisov Igor Vladimirovich

    2011-07-01

    Full Text Available For all countries with imperfect technology and the institutional environment (low culture and organization of production, high levels of corruption, the small middle class, not necessarily the execution of laws, etc., even such strong measures to support the economy like a direct financing of firms and territories, protectionism, stimulation of demand, etc. does not give significant effect. For Russia, which objectively have to be attributed to such countries, extremely relevant management system development, capable of overcoming difficulties, starting with the knees and the resistance of the imperfect (bad technological and institutional environment. Several theoretical solutions recently obtained through the development of the theory of economic-technological development of civilization, can create the mechanism and conditions of such a system.

  3. The significance of pretreatment anemia in the era of R-IPI and NCCN-IPI prognostic risk assessment tools: a dual-center study in diffuse large B-cell lymphoma patients.

    Science.gov (United States)

    Troppan, Katharina T; Melchardt, Thomas; Deutsch, Alexander; Schlick, Konstantin; Stojakovic, Tatjana; Bullock, Marc D; Reitz, Daniel; Beham-Schmid, Christine; Weiss, Lukas; Neureiter, Daniel; Wenzl, Kerstin; Greil, Richard; Neumeister, Peter; Egle, Alexander; Pichler, Martin

    2015-12-01

    Anemia is frequently identified at the time of diagnosis in patients with diffuse large B-cell lymphoma (DLBCL); however, studies addressing the prognostic significance of this important clinical parameter are lacking. In this dual-center study of patients with DLBCL (n = 556) treated with rituximab-containing regimens, we evaluated the prognostic relevance of anemia at diagnosis in a training set (n = 211) and validated our findings in a second independent patient cohort (n = 345). Using Kaplan-Meier curves as well as univariate and multivariate Cox regression models, we analyzed the impact of anemia on 5-year overall survival (OS) and 5-year disease-free survival (DFS) alongside established prognostic indicators including age, tumor stage, the revised International Prognostic Index (R-IPI), and the recently published NCCN-IPI. The influence of anemia on the predictive accuracy of IPI, R-IPI, and NCCN-IPI prognosis scores was subsequently determined using the Harrell's concordance index. Anemia was an independent predictor of impaired OS and DFS at 5 years in both DLBCL patient cohorts (P IPI or NCCN-IPI score. In survival analysis, the estimated concordance index, using IPI, R-IPI, and NCCN-IPI stratification measures (0.69, 0.64, and 0.70, respectively), improved to 0.70, 0.68, and 0.73, respectively, when anemia was also considered. In this study, we have demonstrated that anemia at the time of diagnosis is an independent predictor of impaired clinical outcome in DLBCL. Furthermore, consideration of hemoglobin levels may improve the accuracy of recently established prognostic tools in lymphoma. Our data encourage further evaluation of the prognostic utility of this readily accessible biological parameter in prospective clinical trials. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  4. Practical steps toward integrating economic, social and institutional elements in fisheries policy and management

    DEFF Research Database (Denmark)

    Stephenson, Robert L.; Benson, Ashleen J.; Brooks, Kate

    2017-01-01

    of explicit social, economic and institutional objectives; a general lack of process (frameworks, governance) for routine integration of all four pillars of sustainability; and a bias towards biological considerations. Practical integration requires a ‘systems’ approach with explicit consideration...... of strategic and operational aspects of management; multidisciplinary or transdisciplinary evaluations; practical objectives for the four pillars of sustainability; appropriate participation; and a governance system that is able to integrate these diverse considerations in management. We challenge all involved...... governance....

  5. The Impact of Institutions on Foreign Policy Think Tanks in France and Denmark

    DEFF Research Database (Denmark)

    Rahbek-Clemmensen, Jon; Schmitt, Olivier

    2017-01-01

    Even though France is an active player on the world stage, its foreign and security think tank milieu is smaller than that of similar powers, most notably the United Kingdom. Comparing French think tanks with those in Denmark illustrates how French institutional structures constrain think tank...... think tanks perform well in spite of these structures, which indicates that they could flourish and compete at the highest international level if given better structural conditions....

  6. Openness, Institutions, and Policies: Determinants of Globalisation and Economic Growth in Developing Countries

    OpenAIRE

    Rolf Kappel

    2003-01-01

    Globalisation describes the increasing integration of national economies through international trade, capital transfers, and the exchange of information or knowledge. This paper focuses exclusively on trade integration. Most economists hold that reducing trade barriers has a decisive positive effect on economic growth and poverty reduction (“openness hypothesis”). However, some economists diagnose deficient or weakly enforced non-market institutions as the major cause of slow growth. The main...

  7. Using International Polar Days to Engage and Experiment with Science - Outreach Partnerships in IPY

    Science.gov (United States)

    Salmon, R. A.; Munro, N.; Carlson, D.; Pauls, M.; Zicus, S.

    2008-12-01

    The International IPY Education, Outreach, and Communication Committee developed quarterly International Polar Days in response to pressure from educators and media wishing to remain involved in IPY, throughout IPY. Between September 2007 and March 2009 these events focus on aspects of polar research that are both specific enough to allow depth of understanding, but also broad enough to highlight the interconnectivity of polar science. Each day has experimented with different communication tools including multilingual activity and summary sheets, live radio and web events, press releases, local lectures and engagement at conferences. A virtual balloon launch helps us to assess our reach and develop plans for the next event. The talk will present an evaluation from the balloon launch as well as lessons learnt from activities that had varying degrees of success.

  8. Policies, Programmes and Institutions of Water Sector in Sub-Saharan Africa

    International Nuclear Information System (INIS)

    Krhoda, G.O

    2001-01-01

    Meaningful investment in the water sector can easily increase food production and productivity of human resources and thus stimulate economic growth, human and environmental health. The author indicates that, the Mar del Plata Action Plan (1977), the New Delhi Statement (1990), Dublin Statement (1991)and the Agenda 21 Chapter 18 of UNCED (1992) emphasise the urgent need for integrated, sustainable water resources management. The publication looks at the policy development in the water sector, the disparities in the allocation of water supplies in the urban and the rural areas, the importance of water in the development of the industrial sector and how to manage the demand for water in sub-Saharan Africa

  9. Equity policies in higher education : a legal evaluation of institutional responses

    OpenAIRE

    Faakye, Solomon

    2007-01-01

    ABSTRACT Higher education equity policies have for as long as they have existed provoked serious legal controversy, especially in the largest system of higher education, i.e. the USA. In as much as these legal troubles have not arisen (yet) in Ghana, it can’t be taken for granted that such problems are far-fetched. In that sense this study is a work ahead of its time; in drawing analogies from American case Law, the work attempts to predict the possible legal issues that may arise in th...

  10. Perspectives on European Governance in Comparative Perspective: Interests, Institutions and Policy-Making

    DEFF Research Database (Denmark)

    -making’, at Freie Universität in Berlin on July 4 and 5, 2014. The papers aim at encapsulating the versatility of Adrienne’s scholarship by addressing core themes regarding ‘EU Governance’, ‘Policy Analysis’, and ‘Regulation and Governance’. A number of acknowledgements are appropriate regarding the birthday...... conference and this collection. First, we wish to recognize the team assisting Tanja Börzel who organized the conference and edited the Festschrift. Special thanks go to Luisa Linke and Katja Pomianowicz. Second, we would like to extend our gratitude to the funding bodies which made the event and collection...

  11. "Got Snow?" Education and Outreach for the IPY

    Science.gov (United States)

    Turrin, M.; Bell, R. E.; Pfirman, S.; Maru, P.

    2004-12-01

    The "Bridging the Poles: Education Linked with Research" workshop of June 23-25, brought together an international group of 65 scientists, educators and media specialists to define strategies to engage the next generation of polar scientists, engineers and leaders, and inspire the general public. The workshop results emphasized the need to leverage emerging science programs with meaningful education and outreach programming that is rolled out to the public as major media events. Participants advocated a broad interdisciplinary approach, recognizing that the poles have a rich cultural heritage and fascinating history. Linking research events with student fascination about polar environments, peoples and histories of exploration, can help improve science, math, reading, and other skills. Distance learning with web course delivery is a powerful tool to reach advanced students and to help develop a new generation of researchers among Arctic indigenous peoples. Successful examples of this approach include the University of the Arctic's PhD network, and collaborative field courses. Field experiences build life-long advocates of the poles for students, teachers, and the media alike. Establishing connections among scientists, educators and informal outreach venues in their own community, can have long-lasting impact. "Think Globally/Act Locally" and the complementary "Think Locally/Act Globally" will be important themes for local, national and international IPY programming. Imagine a semi-trailer truck labeled "Got Snow?" traversing the country loaded with polar gear, interactive activities and a snowmaker; polar exhibitions opening at natural history and art museums and zoos; polar-themed postage stamps; national polar book-of-the-month recommendations; made-for-TV polar documentaries; and a rich, multidisciplinary and multilingual web portal. To meet these opportunities requires coordination, linking communities, and high-bandwidth access to high quality content from the

  12. Arctic air pollution: New insights from POLARCAT-IPY

    International Nuclear Information System (INIS)

    Law, Katharine S.; Ancellet, Gerard; Pelon, Jacques; Thomas, Jennie L.; Stohl, Andreas; Quinn, Patricia K.; Brock, Charles A.; Burkhart, John F.

    2014-01-01

    Given the rapid nature of climate change occurring in the Arctic and the difficulty climate models have in quantitatively reproducing observed changes such as sea ice loss, it is important to improve understanding of the processes leading to climate change in this region, including the role of short-lived climate pollutants such as aerosols and ozone. It has long been known that pollution produced from emissions at mid latitudes can be transported to the Arctic, resulting in a winter/spring aerosol maximum known as Arctic haze. However, many uncertainties remain about the composition and origin of Arctic pollution throughout the troposphere; for example, many climate-chemistry models fail to reproduce the strong seasonality of aerosol abundance observed at Arctic surface sites, the origin and deposition mechanisms of black carbon (soot) particles that darken the snow and ice surface in the Arctic is poorly understood, and chemical processes controlling the abundance of tropospheric ozone are not well quantified. The International Polar Year (IPY) Polar Study using Aircraft, Remote Sensing, Surface Measurements and Models, Climate, Chemistry, Aerosols and Transport (POLARCAT) core project had the goal to improve understanding about the origins of pollutants transported to the Arctic; to detail the chemical composition, optical properties, and climate forcing potential of Arctic aerosols; to evaluate the processes governing tropospheric ozone; and to quantify the role of boreal forest fires. This article provides a review of the many results now available based on analysis of data collected during the POLARCAT aircraft-, ship-, and ground-based field campaigns in spring and summer 2008. Major findings are highlighted and areas requiring further investigation are discussed. (authors)

  13. Community Needs Assessment and Portal Prototype Development for an Arctic Spatial Data Infrastructure (ASDI): A Contribution to an IPY Data Cyberinfrastructure

    Science.gov (United States)

    Wiggins, H. V.; Warnick, W. K.; Hempel, L. C.; Henk, J.; Sorensen, M.; Tweedie, C. E.; Gaylord, A.; Behr, S.

    2006-12-01

    As the creation and use of geospatial data in research, management, logistics, and education applications has proliferated, there is now a tremendous potential for advancing the IPY initiative through a variety of cyberinfrastructure applications, including Spatial Data Infrastructure (SDI) and related technologies. SDIs provide a necessary and common framework of standards, securities, policies, procedures, and technology to support the effective acquisition, coordination, dissemination and use of geospatial data by multiple and distributed stakeholder and user groups. Despite the numerous research activities in the Arctic, there is no established SDI and, because of this lack of a coordinated infrastructure, there is inefficiency, duplication of effort, and reduced data quality and search ability of arctic geospatial data. The urgency for establishing this framework is significant considering the myriad of data that is likely to be collected in celebration of the International Polar Year (IPY) in 2007-2008 and the current international momentum for an improved and integrated circumarctic terrestrial-marine-atmospheric environmental observatories network. The key objective of this project is to lay the foundation for full implementation of an Arctic Spatial Data Infrastructure (ASDI) through two related activities: (1) an assessment - via interviews, questionnaires, a workshop, and other means - of community needs, readiness, and resources, and (2) the development of a prototype web mapping portal to demonstrate the purpose and function on an arctic geospatial one-stop portal technology and to solicit community input on design and function. The results of this project will be compiled into a comprehensive report guiding the research community and funding agencies in the design and implementation of an ASDI to contribute to a robust IPY data cyberinfrastructure.

  14. Hedgehog pathway inhibition in chondrosarcoma using the smoothened inhibitor IPI-926 directly inhibits sarcoma cell growth.

    Science.gov (United States)

    Campbell, Veronica T; Nadesan, Puviindran; Ali, S Amanda; Wang, Chang Ye Yale; Whetstone, Heather; Poon, Raymond; Wei, Qingxia; Keilty, John; Proctor, Jennifer; Wang, Lauren W; Apte, Suneel S; McGovern, Karen; Alman, Benjamin A; Wunder, Jay S

    2014-05-01

    Hedgehog (Hh) pathway inhibition in cancer has been evaluated in both the ligand-independent and ligand-dependent settings, where Hh signaling occurs either directly within the cancer cells or within the nonmalignant cells of the tumor microenvironment. Chondrosarcoma is a malignant tumor of cartilage in which there is ligand-dependent activation of Hh signaling. IPI-926 is a potent, orally delivered small molecule that inhibits Hh pathway signaling by binding to Smoothened (SMO). Here, the impact of Hh pathway inhibition on primary chondrosarcoma xenografts was assessed. Mice bearing primary human chondrosarcoma xenografts were treated with IPI-926. The expression levels of known Hh pathway genes, in both the tumor and stroma, and endpoint tumor volumes were measured. Gene expression profiling of tumors from IPI-926-treated mice was conducted to identify potential novel Hh target genes. Hh target genes were studied to determine their contribution to the chondrosarcoma neoplastic phenotype. IPI-926 administration results in downmodulation of the Hh pathway in primary chondrosarcoma xenografts, as demonstrated by evaluation of the Hh target genes GLI1 and PTCH1, as well as inhibition of tumor growth. Chondrosarcomas exhibited autocrine and paracrine Hh signaling, and both were affected by IPI-926. Decreased tumor growth is accompanied by histopathologic changes, including calcification and loss of tumor cells. Gene profiling studies identified genes differentially expressed in chondrosarcomas following IPI-926 treatment, one of which, ADAMTSL1, regulates chondrosarcoma cell proliferation. These studies provide further insight into the role of the Hh pathway in chondrosarcoma and provide a scientific rationale for targeting the Hh pathway in chondrosarcoma.

  15. Towards an effective partnership policy for improving urban low-income housing provision in Nigeria: New institutional economics perspective.

    Directory of Open Access Journals (Sweden)

    Job Taiwo Gbadegesin

    2017-07-01

    Full Text Available Recent critique against the past urban housing provision strategies in Nigeria was that the low-income groups are marginalised. It then led to the adoption of public private partnership (PPP initiative with a view to pursuing the broad goal of housing-for-all in Nigeria. Most recent studies have however criticised the effectiveness of the existing PPP practice in the housing provision structure without providing a pragmatic suggestion towards an effective framework for improvement. It thus raised the question; what are the main causes of ineffectiveness of existing PPP in housing provision and how can an effective PPP policy framework for urban low-income housing be achieved in Nigeria? This study utilised the concepts of new institutional economics (NIE - a theoretical and methodological underpinning for multi-actors’ policy matters. Using qualitative data from structured interview and credible literature sources, findings indicate that uncertainties in land accessibility, high transaction costs and the developers’ high profit agenda, are the major causes of PPP ineffectiveness for housing provision, which are also attributed to lack of a specific PPP policy that recognises all income groups and their roles on housing provision. End-users suggested that government could have a negotiation with land owners and building materials dealers to address the housing problem. In conclusion, it is established in this study that adoption of all-inclusive conceptual approach described within the context of NIE thought can facilitate an effective planning for urban low-income housing in Nigeria.

  16. Power of the policy: how the announcement of high-stakes clinical examination altered OSCE implementation at institutional level

    Directory of Open Access Journals (Sweden)

    Lin Chi-Wei

    2013-01-01

    Full Text Available Abstract Background The Objective Structured Clinical Examination (OSCE has been widely applied as a high-stakes examination for assessing physicians’ clinical competency. In 1992, OSCE was first introduced in Taiwan, and the authorities announced that passing the OSCE would be a prerequisite for step-2 medical licensure examination in 2013. This study aimed to investigate the impacts of the announced national OSCE policy on implementation of OSCE at the institutional level. Further, the readiness and the recognition of barriers toward a high-stakes examination were explored. Methods In 2007 and 2010, the year before and after the announcement of high-stakes OSCE policy in 2008, respectively, questionnaires on the status of OSCE implementation were distributed to all hospitals with active OSCE programs in Taiwan. Information on OSCE facilities, equipment, station length, number of administrations per year, and the recognition of barriers to the success of implementing an OSCE were collected. The missing data were completed by telephone interviews. The OSCE format, administration, and facilities before and after the announcement of the nationwide OSCE policy were compared. Results The data were collected from 17 hospitals in 2007 and 21 in 2010. Comparing the OSCE formats between 2007 and 2010, the number of stations increased and the station length decreased. The designated space and the equipment for OSCE were also found to have been improved. As for the awareness of OSCE implementation barriers, the hospital representatives concerned mostly about the availability and quality of standardized patients in 2007, as well as space and facilities in 2010. Conclusions The results of this study underscored an overall increase in the number of OSCE hospitals and changes in facilities and formats. While recruitment and training of standardized patients were the major concerns before the official disclosure of the policy, space and facilities became the

  17. Power of the policy: how the announcement of high-stakes clinical examination altered OSCE implementation at institutional level.

    Science.gov (United States)

    Lin, Chi-Wei; Tsai, Tsuen-Chiuan; Sun, Cheuk-Kwan; Chen, Der-Fang; Liu, Keh-Min

    2013-01-24

    The Objective Structured Clinical Examination (OSCE) has been widely applied as a high-stakes examination for assessing physicians' clinical competency. In 1992, OSCE was first introduced in Taiwan, and the authorities announced that passing the OSCE would be a prerequisite for step-2 medical licensure examination in 2013. This study aimed to investigate the impacts of the announced national OSCE policy on implementation of OSCE at the institutional level. Further, the readiness and the recognition of barriers toward a high-stakes examination were explored. In 2007 and 2010, the year before and after the announcement of high-stakes OSCE policy in 2008, respectively, questionnaires on the status of OSCE implementation were distributed to all hospitals with active OSCE programs in Taiwan. Information on OSCE facilities, equipment, station length, number of administrations per year, and the recognition of barriers to the success of implementing an OSCE were collected. The missing data were completed by telephone interviews. The OSCE format, administration, and facilities before and after the announcement of the nationwide OSCE policy were compared. The data were collected from 17 hospitals in 2007 and 21 in 2010. Comparing the OSCE formats between 2007 and 2010, the number of stations increased and the station length decreased. The designated space and the equipment for OSCE were also found to have been improved. As for the awareness of OSCE implementation barriers, the hospital representatives concerned mostly about the availability and quality of standardized patients in 2007, as well as space and facilities in 2010. The results of this study underscored an overall increase in the number of OSCE hospitals and changes in facilities and formats. While recruitment and training of standardized patients were the major concerns before the official disclosure of the policy, space and facilities became the focus of attention after the announcement. The study results

  18. A Comparative Analysis of Institutional Capacities for Implementing Disability Policies in East African Countries: Functions of National Councils for Disability

    Directory of Open Access Journals (Sweden)

    Akiko Yokoyama

    2012-08-01

    Full Text Available During the “African Decade of Persons with Disabilities (2000-2009”, East African countries witnessed significant achievements, especially in the development of law, collection of statistics and in funding. However, many persons with disability are still marginalised from opportunities in education, healthcare and employment.Purpose: With the pre-supposition that the lack of institutional capacities for implementing disability policies is the one major stumbling-block which hinders widespread delivery of social services to persons with disabilities in low-income countries, this study makes a comparative analysis of institutional capacities in the disability sectors of Uganda, Kenya and Tanzania.Method: The research methods adopted were a literature survey and a field survey. The framework for analysis consists of: 1 capacities and functions of disability units in central governments, 2 relationships between central and local governments in the disability sector, and 3 relationships between governments and organisations of persons with disability (DPOs. Special attention is paid to the status, roles and functions of national councils for disability (NCDs, the independent statutory bodies recently established in each of the three countries, with clear authority and duties for the implementation of disability policies. The NCDs enable multi-sectoral stakeholders to be involved in the implementation of disability policies; therefore, positive relationships between the governments and DPOs are essential for the smooth functioning of the NCDs.Results: While the result of the field survey in Tanzania reveals several effective approaches for the smooth operation of the NCD, further study is needed to verify whether these approaches would be applicable to other East African countries such as Kenya and Uganda.doi 10.5463/DCID.v23i2.106

  19. African liberation and unity in Nkrumah's Ghana : a study of the role of "Pan-African Institutions" in the making of Ghana's foreign policy, 1957 - 1966

    NARCIS (Netherlands)

    Grilli, Matteo

    2015-01-01

    This dissertation contributes to the study of Nkrumah’s Pan-African policy by examining the role played by three Ghanaian institutions specifically created to support African liberation and unity: the Bureau of African Affairs, the African Affairs Centre, and the Kwame Nkrumah Ideological Institute

  20. The Revenge of History – The Institutional Roots of Post-Communist Family Policy in the Czech Republic, Hungary and Poland

    Czech Academy of Sciences Publication Activity Database

    Hašková, Hana; Saxonberg, S.

    2016-01-01

    Roč. 50, č. 5 (2016), s. 559-579 ISSN 0144-5596 R&D Projects: GA ČR GAP404/10/0021; GA ČR(CZ) GA15-13766S Institutional support: RVO:68378025 Keywords : Historical institutionalism * Family policy * Central Europe Subject RIV: AO - Sociology, Demography Impact factor: 1.239, year: 2016

  1. Routine use of ancillary investigations in staging diffuse large B-cell lymphoma improves the International Prognostic Index (IPI).

    Science.gov (United States)

    Talaulikar, Dipti; Shadbolt, Bruce; Dahlstrom, Jane E; McDonald, Anne

    2009-11-22

    The International Prognostic Index (IPI) is used to determine prognosis in diffuse large B-cell lymphoma (DLBCL). One of the determinants of IPI is the stage of disease with bone marrow involvement being classified as stage IV. For the IPI, involvement on bone marrow is traditionally defined on the basis of histology with ancillary investigations used only in difficult cases to aid histological diagnosis. This study aimed to determine the effect of the routine use of flow cytometry, immunohistochemistry and molecular studies in bone marrow staging upon the IPI. Bone marrow trephines of 156 histologically proven DLBCL cases at initial diagnosis were assessed on routine histology, and immunohistochemistry using two T-cell markers (CD45RO and CD3), two B-cell markers (CD20 and CD79a) and kappa and lambda light chains. Raw flow cytometry data on all samples were reanalysed and reinterpreted blindly. DNA extracted from archived paraffin-embedded trephine biopsy samples was used for immunoglobulin heavy chain and light chain gene rearrangement analysis. Using immunophenotyping (flow cytometry and immunohistochemistry), 30 (19.2%) cases were upstaged to stage IV. A further 8 (5.1%) cases were upstaged using molecular studies. A change in IPI was noted in 18 cases (11.5%) on immunophenotyping alone, and 22 (14.1%) cases on immunophenotyping and molecular testing. Comparison of two revised IPI models, 1) using immunophenotyping alone, and 2) using immunophenotyping with molecular studies, was performed with baseline IPI using a Cox regression model. It showed that the revised IPI model using immunophenotyping provides the best differentiation between the IPI categories. Improved bone marrow staging using flow cytometry and immunohistochemistry improves the predictive value of the IPI in patients with DLBCL and should be performed routinely in all cases.

  2. Design, synthesis and DNA binding properties of orthogonally positioned diamino containing polyamide f-IPI.

    Science.gov (United States)

    Babu, Balaji; Liu, Yang; Plaunt, Adam; Riddering, Camille; Ogilvie, Ross; Westrate, Laura; Davis, Ryan; Ferguson, Amanda; Mackay, Hilary; Rice, Toni; Chavda, Sameer; Wilson, David; Lin, Shicai; Kiakos, Konstantinos; Hartley, John A; Lee, Moses

    2011-01-21

    An orthogonally positioned diamino/dicationic polyamide f-IPI 2 was synthesized. It has enhanced binding affinity, and it showed comparable sequence specificity to its monoamino/monocationic counterpart f-IPI 1. Results from CD and DNase I footprinting studies confirmed the minor groove binding and selectivity of polyamides 1 and 2 for the cognate sequence 5'-ACGCGT-3'. SPR studies provided their binding constants: 2.4 × 10(8)M(-1) for diamino 2, which is ∼4 times higher than 5.4 × 10(7)M(-1) for its monoamino analogue 1. Copyright © 2010 Elsevier Inc. All rights reserved.

  3. International environmental agreements: institutional innovation in European transboundary air pollution policies

    Energy Technology Data Exchange (ETDEWEB)

    Castells, N. [Vrije Universiteit, Amsterdam (Netherlands)

    1999-07-01

    The analysis of International Environmental Agreements (IEAs) is addressed in this study by means of a cross-disciplinary approach with the purpose of building an explanatory framework that includes the various dimensions of the process leading to the definition of an IEA. It concentrates on analysing the factors underlying the emergence of international concern, which builds up to eventually overcome the necessary threshold that enables it to be ultimately transformed into an IEA. The critical factors to explain this dynamic process are analysed from the different disciplinary fields of the social sciences, so as to take advantage of the multiplicity of analytical tools that they contribute twofold. At the theoretical level, the study combines pre-existing analytical tools in an innovative way, as a meta-analytical exercise; at the empirical level, it analyses the most recent developments of a well-known case-study: the agreements on long-range transboundary air pollution in Europe. This is done by analysing in-depth the forthcoming legislation in the field, from the UN-ECE/LATAP Convention and the European Community, which are the two most relevant sources of legislation in this field for Europe. It addresses in particular the forthcoming LRTAP Protocol to abate acidification, eutrophication and ground-level ozone and the recent European Commission's proposals for two Directives on National Emission Ceilings and Ozone in Ambient Air. The policy lessons of this study are that IEAs result from complex processes that depend on the interplay of multiple actors which represent different realities and interests. In order to achieve successful IEAs, these actors have found themselves involved in creating new networks for defining international policies that acknowledge uncertainty in scientific knowledge but do not use it for postponing political decisions. 322 refs.

  4. Report of the Energy Field Institute V on western energy opportunities, problems, and policy issues

    Energy Technology Data Exchange (ETDEWEB)

    Hepworth, J.C.; Foss, M.M.

    1982-12-01

    The fifth Energy and Minerals Field Institute program for Washington, D.C. Congressional and Executive Aides was held during August 15-21, 1982. The five-and-one-half day program was conducted through Wyoming, Colorado and Utah and consisted of visits to: an R and D tertiary petroleum production facility; an historic oil field entering secondary production; a surface uranium mine; a petroleum exploration drilling rig; a surface coal mine; an air cooled, coal-fired power plant; an oil shale site; a geothermal-electrical generating facility; and open pit copper mine and associated smelter and refinery; a petroleum refinery and an oil shale semi-works retort. During the field program, participants had opportunities to view communities affected by these activities, such as Wright City and Gillette, Wyoming, Parachute, Colorado and Milford and Cedar City, Utah. Throughout the program, aides met with local, state and industry officials and citizen leaders during bus rides, meals and site visits.

  5. How corporatist institutions shape the access of citizen groups to policy makers

    DEFF Research Database (Denmark)

    Christiansen, Peter Munk; Mach, André; Varone, Frédéric

    2018-01-01

    Traditional corporatist groups such as business groups and unions still play an important role in many countries, and the rumors exaggerate the decline of corporatist structures. Nevertheless citizen groups have grown in number and political importance. The authors show that Danish and Swiss...... citizen groups have gained better access to the administrative and parliamentary venues in the period 1975–1985 through 2010, but with Swiss citizen groups more successful than their Danish counterparts, particularly with regard to the parliamentary venue. Danish and Swiss neo-corporatism has confronted...... similar socio-economic and political challenges during this period, but the political opportunity structure is more favorable towards citizen groups in Switzerland than in Denmark. The Swiss referendum institution makes parliamentarians more open to popular demands while in Denmark strong unions, a strong...

  6. Report of the Energy Field Institute V on western energy opportunities, problems, and policy issues

    International Nuclear Information System (INIS)

    Hepworth, J.C.; Foss, M.M.

    1982-12-01

    The fifth Energy and Minerals Field Institute program for Washington, D.C. Congressional and Executive Aides was held during August 15-21, 1982. The five-and-one-half day program was conducted through Wyoming, Colorado and Utah and consisted of visits to: an R and D tertiary petroleum production facility; an historic oil field entering secondary production; a surface uranium mine; a petroleum exploration drilling rig; a surface coal mine; an air cooled, coal-fired power plant; an oil shale site; a geothermal-electrical generating facility; and open pit copper mine and associated smelter and refinery; a petroleum refinery and an oil shale semi-works retort. During the field program, participants had opportunities to view communities affected by these activities, such as Wright City and Gillette, Wyoming, Parachute, Colorado and Milford and Cedar City, Utah. Throughout the program, aides met with local, state and industry officials and citizen leaders during bus rides, meals and site visits

  7. Internet Access Practices and Employee Attitudes toward Internet Usage Policy Implementation in Selected Philippines Financial Institutions

    Directory of Open Access Journals (Sweden)

    Maria Sagrario R. Simbulan

    2004-06-01

    Full Text Available This study explores the employees’ concept of appropriate use of Internet facilities as well as their perception of the rights and liabilities, both of the individual and of the organization, associated with the grant of Internet access privileges in the workplace. It further examines how employees perceive their organization’s monitoring of employees online activities and the use of an Internet Usage Policy, whether these are seen as monitoring and control mechanisms or as ways to ensure that Internet access facilities are shared equitably and used responsibly. While the issue of the impact of Internet access on employee productivity will not directly be tackled, the study will provide insights into the frequency and type of usage of Internet facilities in the workplace. Considering the sizeable investment that an organization makes to provide Internet facilities, determining how employees use these facilities to achieve the goals of the organization is, in the very least, interesting and for most organizations concerned with their survival in difficult times, critically important.

  8. Economic and institutional dynamics of electricity markets deregulation: the interaction between sectoral regulation and antitrust policy

    International Nuclear Information System (INIS)

    Fontanel, B.

    2009-01-01

    The purpose of this study is to define regulatory intervention as a part of a global monitoring procedure allowing the definition and adaptation of market structures and rules, given the observed behavior of market participants. Nevertheless, the possible inefficiency in its (decisional) coordination with competition authorities implies further analysis. We thus adopt a comparative methodology based on the studying PJM and NETA wholesale markets. This analysis enables us to stress two possible 'models' in the distribution and coordination of monitoring powers. The first one privileges a strong 'informational coordination' between the sectoral regulator and the Transmission System Operator. By contrast, the second model is characterized by a constrained informational coordination, leading to a greater 'decisional convergence' between regulatory intervention and antitrust policy. Lastly, we put these conclusions into perspective with the specific issue of the achievement of an efficient and integrated European market for electricity. In particular, we stress the need for a single regulatory agency, which should be given autonomous decisional powers in the adoption of regional markets reform initiatives (author)

  9. Service quality in healthcare institutions: establishing the gaps for policy action.

    Science.gov (United States)

    Abuosi, Aaron A; Atinga, Roger A

    2013-01-01

    The authors seek to examine two key issues: to assess patients' hospital service quality perceptions and expectation using SERVQUAL; and to outline the distinct concepts used to assess patient perceptions. Questionnaires were administered to 250 patients on admission and follow-up visits. The 22 paired SERVQUAL expectation and perception items were adopted. Repeated t-measures and factor analysis with Varimax rotation were used to analyse data. Results showed that patient expectations were not being met during medical treatment. Perceived service quality was rated lower than expectations for all variables. The mean difference between perceptions and expectations was statistically significant. Contrary to the SERVQUAL five-factor model, four service-quality factors were identified in the study. Findings have practical implications for hospital managers who should consider stepping up staffing levels backed by client-centred training programmes to help clinicians deliver care to patients' expectations. Limited studies are tailored towards patients' service-quality perception and expectation in Ghanaian hospitals. The findings therefore provide valuable information for policy and practice.

  10. Establishment of the International Power Institute. Final technical report

    Energy Technology Data Exchange (ETDEWEB)

    Julius E. Coles

    2000-08-04

    The International Power Institute, in collaboration with American industries, seeks to address technical, political, economic and cultural issues of developing countries in the interest of facilitating profitable transactions in power related infrastructure projects. IPI works with universities, governments and commercial organizations to render project-specific recommendations for private-sector investment considerations. IPI also established the following goals: Facilitate electric power infrastructure transactions between developing countries and the US power industry; Collaborate with developing countries to identify development strategies to achieve energy stability; and Encourage market driven solutions and work collaboratively with other international trade energy, technology and banking organizations.

  11. Who's counting? Institutional Autonomy and the Production of Activity Data for Disability Policy in France (2006-2014

    Directory of Open Access Journals (Sweden)

    Pierre-Yves Baudot

    2014-07-01

    Full Text Available This article deals with the use of figures for public action piloting in disability policy. This particular public action sector seems to lack piloting figures and comparable data for the monitoring of action in institutions in charge of granting social services for disabled persons, the Maisons départementales des personnes handicapées (MDPH. Based on fieldwork carried out since 2011 in this sector, this article reveals that the production of specific activity figures requires resource mobilisation and precise tasks on the part of organisations. The production of activity data therefore can reflect the autonomy of these administrative organisations. In limiting the capacity of these organisations specifically tasked with benefits attribution decisions, political authorities have also limited the autonomy they could in theory have claimed, and, in so doing, have limited their capacity to make these decisions independently of the political configurations and economic situations within which these benefits are recognised

  12. Movements and institutionally of international environmental policy: Genesis and conceptual bases

    International Nuclear Information System (INIS)

    Gomez G, Luis Jair

    2001-01-01

    Environmental problems have gone, when it comes to their discussion, beyond the purely scientific arena, to being also discussed at a political stage, giving birth to what has been called political ecology. The dimensions of the problem, as well as its global nature, have created some sort of political institutionalism, which ranges from international organisms, UNO, World Bank; etc, to very local organizations. This approach has two conceptual positions al its base: environmentalism, which gives preeminence to man over nature, with its trends of Eco-development which leans on local ecology and culture; and sustainable development which leans on economic growth which should generate resources to alleviate environmental damage and social inequities. On the other hand all the unbreakable links with the other living beings and the physical surroundings. It also has two trends: Deep Ecology which advocates respect for nature as a systemic unit within which man is immerse; and Global Eco-ethics which stand for political action that departs from accepting current man's responsibility towards the forthcoming human societies, whose well-being will depend on our respect for natural dynamics

  13. Land Rights of Community Forest Plantation Policy: Analysis from an Institutional Perspective

    Directory of Open Access Journals (Sweden)

    Bramasto Nugroho

    2012-01-01

    Full Text Available This study aimed to describe the land rights of bussiness permit for timber utilization from community forestplantation (IUPHHK-HTR in Indonesia and to predict its effectiveness based on property rights theory relatedto target group characteristics. Field survey was conducted in November 2008 to April 2009 in Riau and SouthKalimantan Provinces. The results showed that from the property rights theory perspective, the land rights forHTR could be categorized as lease or management rights consisted of rights to exclude, to manage, to use, andto access, without rights to transfer and to bequeath. This suggests that the mechanism of transfer of rights fromthe government to the holder of IUPHHK-HTR as a temporary transfer of rights. As a result, the government needsto regulate a rigid and detailed obligation for IUPHHK-HTR holders that may not be fulfilled by the farmers. Thegranting of permits for a long period (up to 95 years is predicted to lose the meanings, caused of the prohibitionon inheritance of the permits. From these findings it is predicted to reduce the interest of farmers to invest in theHTR.Keywords: land rights, community forest plantation, institutions, property rights, lease/management rights

  14. Beyond interests and institutions: US health policy reform and the surprising silence of big business.

    Science.gov (United States)

    Smyrl, Marc E

    2014-02-01

    Interest-based arguments do not provide satisfying explanations for the surprising reticence of major US employers to take a more active role in the debate surrounding the 2010 Patient Protection and Affordable Care Act (ACA). Through focused comparison with the Bismarckian systems of France and Germany, on the one hand, and with the 1950s and 1960s in the United States, on the other, this article concludes that while institutional elements do account for some of the observed behavior of big business, a necessary complement to this is a fuller understanding of the historically determined legitimating ideology of US firms. From the era of the "corporate commonwealth," US business inherited the principles of private welfare provision and of resistance to any expansion of government control. Once complementary, these principles are now mutually exclusive: employer-provided health insurance increasingly is possible only at the cost of ever-increasing government subsidy and regulation. Paralyzed by the uncertainty that followed from this clash of legitimate ideas, major employers found themselves unable to take a coherent and unified stand for or against the law. As a consequence, they failed either to oppose it successfully or to secure modifications to it that would have been useful to them.

  15. A Cross-Validation Study of Police Recruit Performance as Predicted by the IPI and MMPI.

    Science.gov (United States)

    Shusman, Elizabeth J.; And Others

    Validation and cross-validation studies were conducted using the Minnesota Multiphasic Personality Inventory (MMPI) and Inwald Personality Inventory (IPI) to predict job performance for 698 urban male police officers who completed a six-month training academy. Job performance criteria evaluated included absence, lateness, derelictions, negative…

  16. Inwald Personality Inventory (IPI) and Inwald Survey 3 (IS3): Hilson Research Abstracts.

    Science.gov (United States)

    Hilson Research Inc., Kew Gardens, NY.

    Abstracts, titles, and sources are given for documents concerning the Inwald Personality Inventory (IPI) and Inwald Survey 3 (IS3). The following titles are included: (1) "Five-Year Follow-Up Study of Departmental Terminations as Predicted by 16 Preemployment Psychological Indicators"; (2) "The Predictive Validity of Psychological…

  17. IPI and Behavior: An Evaluation of Cognitive and Affective Change. Research Monograph 2.

    Science.gov (United States)

    Spinks, Nellie J.

    The Individually Prescribed Instruction (IPI) program provides instruction based on specific objectives correlated with placement instruments, teaching methods, and individualized materials for wide ranges of differences in the classroom. The program was implemented in the five elementary schools of Lowndes County, Georgia, in 1970-72. This study…

  18. Minneapolis IPI Mathematics Project 1971-72: Third Year Evaluation. A Title I, ESEA Project.

    Science.gov (United States)

    Johnson, Lary

    The evaluation of the third year of the Individually Prescribed Instruction (IPI) mathematics project at the Hall School in Minneapolis (grades 1-6) is discussed, and results for the three years are summarized. The process evaluation during the third year concentrated on three areas: group instructional methods, instructional materials other than…

  19. Inter-Pregnancy Interval (IPI): What Is The Ideal? | Eleje | Afrimedic ...

    African Journals Online (AJOL)

    Inter-Pregnancy Interval (IPI): What Is The Ideal? GU Eleje, IU Ezebialu, NO Eke. Abstract. No Abstract Available Afrimedic Journal 2011;2(1):36-38. Full Text: EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT · AJOL African Journals Online. HOW TO USE AJOL.

  20. Changes in Scholastic Achievement of Disadvantaged Children Enrolled in Follow Through PEP-IPI Project.

    Science.gov (United States)

    Fesler, Elizabeth; And Others

    This paper briefly summarizes the findings of a study of the effects of the Follow Through Primary Education Project-Individually Prescribed Instruction (PEP-IPI) model. The project was designed to provide individualized instruction (with emphasis on perceptual and motor abilities, language concepts, classifying skills and reasoning abilities) to…

  1. [Application for Individual School Participation; Individually Prescribed Instruction Mathematics (IPI), Part I, Part II, Part III.

    Science.gov (United States)

    Research for Better Schools, Inc., Philadelphia, PA.

    The questionnaire reproduced here reflects the criteria used in the selection of a school for participation in the Individually Prescribed Instruction (IPI) Math program. Administrative commitment, teacher commitment, willingness to retrain, and willingness to participate in research are surveyed, as well as the past history of the school in terms…

  2. First Year Evaluation IPI Mathematics Project, Hall School 1969-1970.

    Science.gov (United States)

    Hestwood, Diana

    A three-year Individually Prescribed Instruction (IPI) project in mathematics was initiated at Hall Elementary School in Minneapolis, September 1969, under ESEA Title I funding. Hall School is in a low income area of the city and nearly all children in the project were considered educationally disadvantaged. First year evaluation results show that…

  3. ANALYSIS OF THE IMPACT OF INSTITUTIONAL ENVIRONMENT ON THE POLICY OF OIL COMPANIES IN THE SPHERE OF SUBSOIL USE

    Directory of Open Access Journals (Sweden)

    Tokarev A. N.

    2016-06-01

    Full Text Available Oil and gas sector is key sector for the Russian economy. General socio-economic benefits from the development of oil and gas resources are largely dependent on the policies implemented by oil companies. Therefore, the most important task of the state is to create conditions that would ensure socially-oriented behavior of the oil companies. The main purpose of research is to develop recommendations for the establishment of these conditions with regard to oil production. The paper analyzes the current situation with the development of oil resources in Russia, the behavior of the oil companies in the sphere of subsoil use. The methodical approach to analyzing the behavior of companies with respect to the issues of development of oil fields in various conditions (rigidity of the state policy in the sphere of subsoil use is provided. It has been shown that it is necessary a balanced combination of restrictive measures and mechanisms for financial and economic incentives. The findings may be used in the formation of the institutional environment in the sphere of subsoil use.

  4. Civic And Ethical Education In Institutions Of Higher Learning In Ethiopia Challenges Opportunities And Policy Implications

    Directory of Open Access Journals (Sweden)

    Mohammed Yimer

    2017-10-01

    society cannot succeed. It is imperative therefore that educators policymakers and members of civil society make the case and ask for the support of civic education from all segments of society and from the widest range of institutions and government.

  5. Fragmentation in the Public Administration for Climate Change Mitigation: A Major Institutional Constraint for Energy Policy in the Transportation Sector of Thailand

    Directory of Open Access Journals (Sweden)

    Ratchaphong Klinsrisuk

    2013-07-01

    Full Text Available This paper focuses on how fragmentation in public administration has become a major institutional constraint on CO2 emission mitigation policies in Thailand, particularly for energy policy in the transportation sector. Most of our data are narratives and descriptions derived from in-depth interviews with various governmental agencies and academics. It was found that in practice, the environmental policy link between separated sectors continues to be weak because of the lack of appropriate institutional structure for integration. We conclude that the institutions tend to be independent, fragmented, and working on relatively narrow mandates. The closed decision-making processes and the organizational structures strongly bias the different administrative units towards their respective interests.

  6. Barriers and challenges of implementing tobacco control policies in hospitals: applying the institutional analysis and development framework to the Catalan Network of Smoke-Free Hospitals.

    Science.gov (United States)

    Martinez, Cristina

    2009-08-01

    This article analyzes tobacco control policies in hospitals based on the experience of the Catalan Network of Smoke-Free Hospitals, Spain. The objective is to understand through this case study how tobacco policies are designed and implemented in health care organizations. Because tobacco control is a public health issue, governmental, institutional, and professional involvement is necessary. This article identifies and examines the structure and relationships among the different actors involved in the tobacco control policies in health care organizations using Ostrom's Institutional Analysis and Development framework.This theory helps one understand the policy failures and rethink the future challenges. Critical issues should be reviewed to enhance implementation of smoke-free hospitals-such as assuring the compliance of nonsmoking areas and introducing compulsory tobacco cessation activities that are promoted and monitored by the public administration. The author suggests that relying primarily on an organization's interpretation of rules leads to irregular implementation.

  7. Social Sciences and Humanities in the IPY 2007/08: An Integrating Mission

    Science.gov (United States)

    Krupnik, I.

    2004-12-01

    Our understanding of the human dimension of polar regions is immensely greater today than at the beginning of polar science. In the IPY 2007/2008, social sciences and humanities aspire to become fully engaged members of a new multidisciplinary effort. They are eager to address issues of partnership and public involvement, socio-economic development, governance, cultural viability and human rights of polar residents. These societal issues are among the top priorities of the IPY 2007/2008 mission to enhance the understanding of human-environmental interactions in the polar systems and to promote the value of polar science and global monitoring among the public at large. Other social issues-security, diplomacy, demography, health, education, communications-are also critical to polar research and to the scientific advance into the Arctic and Antarctica. The success of IPY 2007/08 requires the articulation of the common interest among scientists, polar peoples, economic actors, and sovereign nations, facing current global change. Experience from various regions present convincing evidence that lasting progress in the understanding and preservation of the environment can only be achieved if local populations are respected and involved. Research made at the "poles" is, thus, crucial for establishing models of equity and involvement, partnership and outreach. In this mission of the IPY 2007/2008 program social scientists and humanists are to make credible contributions. One of the key missions for social scientists under the IPY 2007/2008 program is to develop cooperative observation programs involving interested indigenous experts, subsistence users, and other polar residents. Through generations of life in the polar environment, polar people have developed long-standing knowledge and observation techniques in recording and interpreting a broad range of signals and phenomena in the polar systems. Efforts to integrate local experts into year-round circumpolar observing

  8. Is it possible to improve prognostic value of NCCN-IPI in patients with diffuse large B cell lymphoma? The prognostic significance of comorbidities.

    Science.gov (United States)

    Antic, Darko; Jelicic, Jelena; Trajkovic, Goran; Balint, Milena Todorovic; Bila, Jelena; Markovic, Olivera; Petkovic, Ivan; Nikolic, Vesna; Andjelic, Bosko; Djurasinovic, Vladislava; Sretenovic, Aleksandra; Smiljanic, Mihailo; Vukovic, Vojin; Mihaljevic, Biljana

    2018-02-01

    The prognostic value of the International Prognostic Index (IPI) has been re-evaluated in the rituximab-treated diffuse large B cell lymphoma (DLBCL) patients. Accordingly, National Comprehensive Cancer Network-IPI (NCCN-IPI) has been introduced to estimate prognosis of DLBCL patients. However, comorbidities that frequently affect elderly DLBCL patients were not analyzed. The aim of this study was to evaluate the prognostic significance of comorbidities using Charlson Comorbidity Index (CCI) in 962 DLBCL patients. According to CCI, majority of patients (73.6%) did not have any comorbidity, while high CCI (≥ 2) was observed in 71/962 (7.4%) patients, and in 55/426 (12.9%) of the elderly patients aged ≥ 60 years. When the CCI was analyzed in a multivariate model along with the NCCN-IPI parameters, it stood out as a threefold independent risk factor of a lethal outcome. Also, we have developed a novel comorbidity-NCCN-IPI (cNCCN-IPI) by adding additional 3 points if the patient had a CCI ≥ 2. Four risk groups emerged with the following patient distribution in low, low-intermediate, high-intermediate, and high group: 3.4, 34.3, 49.4, and 12.5%, respectively. The prognostic value of the new cNCCN-IPI was 2.1% improved compared to that of the IPI, and 1.3% improved compared to that of the NCCN-IPI (p IPI showed a 5.1% better discriminative power compared to that of the IPI, and 3.6% better compared to the NCCN-IPI. The NCCN-IPI enhanced by the CCI and combined with redistributed risk groups is better for differentiating risk categories in unselected DLBCL patients, especially in the elderly.

  9. Examining the Impact of the National Institutes of Health Public Access Policy on the Citation Rates of Journal Articles.

    Science.gov (United States)

    De Groote, Sandra L; Shultz, Mary; Smalheiser, Neil R

    2015-01-01

    To examine whether National Institutes of Health (NIH) funded articles that were archived in PubMed Central (PMC) after the release of the 2008 NIH Public Access Policy show greater scholarly impact than comparable articles not archived in PMC. A list of journals across several subject areas was developed from which to collect article citation data. Citation information and cited reference counts of the articles published in 2006 and 2009 from 122 journals were obtained from the Scopus database. The articles were separated into categories of NIH funded, non-NIH funded and whether they were deposited in PubMed Central. An analysis of citation data across a five-year timespan was performed on this set of articles. A total of 45,716 articles were examined, including 7,960 with NIH-funding. An analysis of the number of times these articles were cited found that NIH-funded 2006 articles in PMC were not cited significantly more than NIH-funded non-PMC articles. However, 2009 NIH funded articles in PMC were cited 26% more than 2009 NIH funded articles not in PMC, 5 years after publication. This result is highly significant even after controlling for journal (as a proxy of article quality and topic). Our analysis suggests that factors occurring between 2006 and 2009 produced a subsequent boost in scholarly impact of PubMed Central. The 2008 Public Access Policy is likely to be one such factor, but others may have contributed as well (e.g., growing size and visibility of PMC, increasing availability of full-text linkouts from PubMed, and indexing of PMC articles by Google Scholar).

  10. De-risking concentrated solar power in emerging markets: The role of policies and international finance institutions

    International Nuclear Information System (INIS)

    Frisari, Gianleo; Stadelmann, Martin

    2015-01-01

    Concentrated solar power (CSP) is a promising technology for low-carbon energy systems, as combined with thermal storage it can store solar energy as heat, and deliver power more flexibly and when most needed by the grid. However, its high cost prevents its rapid deployment and affects its affordability in emerging economies. International financial institutions (IFIs) have emerged as key players to enable CSP in emerging economies, especially when cooperating with national policymakers. Through the analysis of two CSP plants in India and Morocco where IFIs provided the lion's share of finance, this paper aims to assess the effectiveness of their support and estimate the impact of IFIs financing on electricity production costs and mobilization of private investments. The two case studies show that public financial institutions can play a leading role in reducing the cost of CSP support on public budgets by providing concessional loans in countries where public and/or private finance would be too expensive, or extending maturities where commercial investors are present but poorly suited for project finance. Finally, we show that, combined with competitive tariff setting mechanism (tenders and auctions), public financial support can also be a cost-effective tool to engage private investors in CSP. -- Highlights: •We analyze the financial model of two large-scale concentrated solar power (CSP) plants in two emerging markets (India and Morocco). •We focus on the role of policies and public finance in reducing investment risks and generation costs. •Development banks' concessional loans can reduce the weight of CSP support on public budgets. •Even when non-concessional, development banks' loans can reduce investment costs by extending debt maturities. •Competitive tariff setting mechanisms can ensure cost-effectiveness of public financial support

  11. Regional Targeting of the Economic Policy of the Russian Federation as an Institution of Regional Spatial Development

    Directory of Open Access Journals (Sweden)

    Alexander Ivanovich Tatarkin

    2016-03-01

    Full Text Available In the article, the task to evaluate the condition of the Russian economy amid slumping energy prices and «exchange of sanctions» is addressed. It also aimes to define the priority directions of the economic policy of the Russian Federation as the full-service institutions capable to maintain the stability and consistency of development. The process of ensuring the spatial structure development of the Russian territories by means of involvement in the development processes the regional and municipal opportunities is offered to initiate with the optimization of the inter-budgetary relations of «municipality — region — federal centre.» All Russian citizens are recommended to treat more strictly and more responsibly the Constitution as the Basic Law supported by the populace and defining the strategic development priorities of the country on a long-term outlook. The methodology of the optimization of the inter-budgetary relations between the Federation, its subjects and municipalities is proved by the evidence-based delineation of powers and responsibility of each level for socio-economic results of work. It is offered to develop the national plan of socio-economic and social development engaging in work the experts and public; its main priorities have to be the improvement of the quality and productivity of the public administration and the spatial structure of the Russian territories. The mechanisms and institutions that help to involve the regions and territories to the implementation of the national plan are proved. The findings and recommendations offered in the paper may be used by the federal authorities in the development and adoption of laws and other regulations on the distribution of authority and optimization of the budgetary process. They are also may be useful for the regional and municipal authorities for the planning and development of the regional spatial structure.

  12. Leveraging the International Polar Year Legacy: Providing Historical Perspective for IPY Education, Outreach and Communication Efforts

    Science.gov (United States)

    Tsukernik, M.; McCaffrey, M. S.

    2006-12-01

    As the International Polar Year 2007-2008 (IPY) is fast approaching, it is important to look back and learn from the previous experience. Over 125 years ago, when an Austrian explorer and naval officer Lt. Karl Weyprecht called for an international yearlong intensive effort to study the Polar Regions, he probably never imagined that his model for international collaboration would become so widely popular. Frustrated by the lack of coordinated, international collaboration in research activities, Weyprecht proposed an intensive burst of research activity over the course of at least a year. The first IPY began in 1882 with 12 nations establishing 13 stations in the Arctic and 2 in the Southern Hemisphere. The initial yearlong plan did not go beyond data collection. However, the idea lived in the minds of scientists worldwide and the second IPY followed the first one 50 years later. By 1932, technology evolved significantly, and on top of ground-based meteorological and geophysical measurements, data collection also included radiosonde and acoustic atmospheric measurements. Occurring during a global economic depression, and between world wars, the second IPY faced many challenges. However, 40 permanent stations were established, some of which are still active. Scientific exploration also reached remote frontiers from Antarctica to the Earth's ionosphere. Less than a decade after the WWII, the idea of the next IPY started to circulate in scientific circles. The world was focused on space exploration and the word "polar" seemed too narrow for the gigantic projects planned for the 1957. That is why the initial idea of the third IPY evolved into the International Geophysical Year (IGY), although polar regions were still a major focus. The success of the IGY is almost overwhelming the first Earth orbiting satellites, a traverse of Antarctica, a discovery of the Radiation Belt, a series of science education films about IGY activities and research themes are just a few

  13. PolarTREC-Celebrating the Legacy of the IPY Through Researcher-Educator Partnerships

    Science.gov (United States)

    Timm, K.; Warburton, J.; Larson, A. M.

    2009-12-01

    Polar TREC-Teachers and Researchers Exploring and Collaborating, a three-year (2007-2009) NSF-funded program, has matched over 40 teachers with polar researchers working in multiple scientific disciplines for 2-8 week Teacher Research Experiences (TRE) in the Arctic and Antarctica during the IPY. PolarTREC contributes to the legacy of the IPY through the creation and dissemination of polar education resources, prolonged teacher-researcher relationships, and contributions to scholarly knowledge on the impacts of TRE's. Products developed during PolarTREC are helping to sustain the widespread interest and enthusiasm in the polar regions generated during the IPY. During their expeditions, participating teachers brought science and information about profound changes at the poles to school, community, and professional audiences through web-based communications, journals, discussion forums, multimedia, and live events. PolarTREC teachers constructed nearly 100 classroom lesson plans and activities as products of their experiences. Live events from the field attracted over 11,000 participants, primarily K-12 students. Although the field experience is central to the PolarTREC TRE Model, many participants cite the relationship they built with their teacher/researcher as one of the best outcomes. Through personal communications, presentations at professional conferences, and continued support of each other’s work through classroom visits or joint proposal development, teachers and researchers have maintained the mutually beneficial relationships established during the IPY. Participating scientists gained access to professional educators with expertise in translating research approaches and results into programs. The need for researchers to explain their research and “boil it down to the raw essence” helped many see how their work fits into a bigger picture, often helping them communicate outside their scientific discipline and to diverse public audiences. Teachers, on

  14. An evaluation of the Integrated Pulmonary Index (IPI) for the detection of respiratory events in sedated patients undergoing colonoscopy.

    Science.gov (United States)

    Berkenstadt, Haim; Ben-Menachem, Erez; Herman, Amir; Dach, Rina

    2012-06-01

    The Integrated Pulmonary Index (IPI™) is a new decision making tool calculated from measured end tidal carbon dioxide (etCO(2)), respiratory rate (RR), oxygen saturation (SpO(2)) and pulse rate (PR) using a fuzzy logic model. The aim of this study was to compare prospectively IPI to respiratory adverse events in patients undergoing moderate sedation for colonoscopy. Following ethics committee approval and personal informed consent 51 adult patients undergoing elective colonoscopy were enrolled. Patients received routine care by the endoscopy staff that were blinded to IPI, etCO(2), and RR; whilst a trained senior anesthesiologist observer, not involved in the procedure, collected this data. 'Requires attention' respiratory adverse events (at least 1 min of SpO(2) ≤ 92 % and/or RR ≤ 8 and or 20 % decrease in etCO(2)) and 'requires intervention' respiratory adverse events (at least 1 min of SpO(2) ≤ 85 % and/or RR = 0) were documented by the observer. There were no differences in etCO(2), RR, SpO(2) and PR between 5778 IPI readings ranging from 1 to 10. Low (1-3), medium (4-6) and high (7-10) IPI groups did not differ in RR, SpO(2) and PR, but etCO(2) was higher in the high IPI group (p = 0.0185). Among requires attention events (n = 113) the IPI was high (7-10) in 53.1 %, intermediate (4-6) in 32.7 %, or low (1-3) in 14.2 %. The presented data demonstrate limited agreement between respiratory physiological parameters and the IPI. Further IPI evaluation and validation is indicated mainly for events requiring immediate intervention and in different patient populations including obese patients.

  15. IPI-504, a novel and soluble HSP-90 inhibitor, blocks the unfolded protein response in multiple myeloma cells.

    Science.gov (United States)

    Patterson, Jon; Palombella, Vito J; Fritz, Christian; Normant, Emmanuel

    2008-05-01

    Inhibitors of heat shock protein (Hsp) 90 induce apoptosis in multiple myeloma (MM) cells, but the molecular mechanisms underlying this cytotoxic outcome are not clear. Here, we investigate the effect of IPI-504, a novel and highly soluble inhibitor of the Hsp90 ATPase activity, on the unfolded protein response (UPR) in MM cells. The UPR is a stress response pathway triggered by sensors located at the endoplasmic reticulum (ER) membrane whose function is to reduce an excessive accumulation of misfolded protein in the ER. During normal development of B-lymphocytes to antibody-producing plasma cells, a partial UPR has been described, where IREalpha and ATF-6 are stimulated, whereas the third sensor, PERK, is not induced. Levels of the activated forms of the three main UPR sensors ATF-6, XBP-1 and PERK/eIF-2 were monitored in two different MM cells lines and one non-MM cell lines under various experimental conditions including incubation with increasing concentration of IPI-504. Also, MM cells were incubated with IPI-504 and several apoptosis markers were monitored. We show here that a partial UPR is constitutively activated in plasma cell-derived MM cells and that IPI-504 can potently inhibit this pathway. IPI-504 achieves this by inactivating the transcription factors XBP1 and ATF6. In addition, IPI-504 also blocks the tunicamycin-induced phosphorylation of eIF2 by PERK. Dose-response and time course experiments reveal that IPI-504's inhibitory effect on the UPR parallels its cytotoxic and pro-apoptotic effects on MM cells. The results presented here suggest that the IPI-504-induced apoptosis might be, in part, mediated by the inhibition of the partial UPR. Other malignancies that rely on intact and efficient UPR to survive could be considered as new indications for Hsp90 inhibitors.

  16. A Phase I Study of FOLFIRINOX Plus IPI-926, a Hedgehog Pathway Inhibitor, for Advanced Pancreatic Adenocarcinoma.

    Science.gov (United States)

    Ko, Andrew H; LoConte, Noelle; Tempero, Margaret A; Walker, Evan J; Kate Kelley, R; Lewis, Stephanie; Chang, Wei-Chou; Kantoff, Emily; Vannier, Michael W; Catenacci, Daniel V; Venook, Alan P; Kindler, Hedy L

    2016-03-01

    In mouse models of pancreatic cancer, IPI-926, an oral Hedgehog inhibitor, increases chemotherapy delivery by depleting tumor-associated stroma. This multicenter phase Ib study evaluated IPI-926 in combination with FOLFIRINOX (5-fluorouracil, leucovorin, irinotecan, oxaliplatin) in patients with advanced pancreatic cancer. Patients were treated with once-daily IPI-926 plus FOLFIRINOX. A 3 + 3 dose escalation design was used, with cohort expansion at the maximum tolerated dose. A subset of patients underwent perfusion computed tomography to assess changes in tumor perfusion. The maximum tolerated dose was identified 1 dose level below standard FOLFIRINOX. Common treatment-related adverse events included liver function test abnormalities, neuropathy, nausea/vomiting, and diarrhea. Objective response rate was high (67%), and patients receiving IPI-926 maintenance showed further declines in CA19-9 levels even after FOLFIRINOX discontinuation. Treatment did not result in consistent increases in tumor perfusion. The study closed early when a separate phase II trial of IPI-926 plus gemcitabine indicated detrimental effects of this combination. This is the first study to demonstrate the feasibility of using FOLFIRINOX as the chemotherapeutic backbone in a clinical trial design. Although robust antitumor activity and acceptable safety were observed with the addition of IPI-926 to this regimen, future development of Hedgehog inhibitors in pancreatic cancer seems unlikely.

  17. The Costs of Online Learning. Creating Sound Policy for Digital Learning: A Working Paper Series from the Thomas B. Fordham Institute

    Science.gov (United States)

    Battaglino, Tamara Butler; Haldeman, Matt; Laurans, Eleanor

    2012-01-01

    The latest installment of the Fordham Institute's "Creating Sound Policy for Digital Learning" series investigates one of the more controversial aspects of digital learning: How much does it cost? In this paper, the Parthenon Group uses interviews with more than fifty vendors and online-schooling experts to estimate today's average…

  18. Granting Credit for College Proficiency and Regents External Degree Examinations in New York State: A Summary of Institutional Policies, 1981-82.

    Science.gov (United States)

    New York State Education Dept., Albany. Bureau of Independent Study and Programs Development.

    A guide is presented for students on the policies and practices of public and private New York colleges and universities in regard to granting credit, course waiver, or advanced standing to those who pass the College Proficiency Examinations (CPEs) and the Regents External Degree Examinations (REDEs). A chart indicates, for each institution and…

  19. Bring the Poles to Your Classroom & Community Through Linked Hands-on Learning & IPY Data

    Science.gov (United States)

    Turrin, M.; Bell, R. E.; Kastens, K. A.; Pfirman, S. L.

    2009-12-01

    Two major legacies of the 4th International Polar Year (IPY 2007-9) are a newly galvanized educational community and an immense volume of polar data collected by the global science community. The tremendous new polar datasets represent a unique opportunity to communicate the nature of the changing poles to student and public audiences through this polar savvy educational community if effective approaches to link data and understanding are employed. We have developed a strategy for polar education that leverages the IPY data resources, linked with the polar education hands-on ‘manipulatives’ (materials that students can manipulate in a dynamic manner). This linked approach leverages the fundamental inquiry based learning but recognizes that particularly in the polar sciences the size of the earth, the remoteness of the poles and the scale of its processes make it difficult for students to explore in a hands-on manner. The linking of polar hands-on ‘manipulatives’ with IPY data provides a bridge between the tangible and the global. Alone manipulative activities can be beneficial in their ability to help students visualize a process or behavior, but without a strong link back to the Earth through data or evidence the understanding of the process is not transferred from the classroom model to the full scale Earth. The use of activities or models is beneficial in connecting the learner to the polar process(es), while the IPY data provides a unique opportunity to ground the polar manipulative experiments in real data. This linked strategy emerged from a series of NSF sponsored IPY Polar Fairs at major science museums that reached in excess of 12,000 people. The design of the fairs was that polar scientists developed activities linking low cost hands-on manipulatives to scientific evidence/data that was displayed in posters, images, and video clips. The participating scientists walked the ‘audience’ through the hands-on manipulative, then discussed their

  20. An improved scheme of IPI-based entity identifier generation for securing body sensor networks.

    Science.gov (United States)

    Hong, Tian; Bao, Shu-Di; Zhang, Yuan-Ting; Li, Ye; Yang, Ping

    2011-01-01

    Securing body sensor network (BSN) in an efficient manner is very important for preserving the privacy of medical data. Protecting data confidentiality, integrity and to authenticate the communicating nodes are basic requirements to secure BSN. The existing method to generate entity identifier (EI) from inter-pulse intervals (IPIs) of heartbeats has its advantages in authenticating and identifying nodes, which however was found in this study that such generated EIs are not so resistant to attacks because of potential error patterns. This paper presents an improved scheme of IPI-based EI generation to eliminate the error patterns. The performance of randomness and node identification, i.e. false acceptance rate and false rejection rate, is experimentally evaluated. The results indicate that compared with the existing one, the new scheme is effective to eliminate the error patterns and thus more tolerant to attacks, while there is no compromise on the randomness level and identification performance.

  1. Predicting compact yarn’s IPI faults by using HVI fiber properties

    Science.gov (United States)

    Üzümcü, M. B.; Kadoğlu, H.

    2017-10-01

    Compact yarns have great value for producers and its importance grow day by day. Its higher tenacity, lower unevenness and lower hairiness –if required- are some of the reasons this yarn type gains importance. Estimation using previous data has a great value in engineering. It helps to understand the product before producing it. This study deals with the effects of HVI fiber properties on compact-spun yarns’ IPI fault results.

  2. The antiproliferative activity of the heat shock protein 90 inhibitor IPI-504 is not dependent on NAD(P)H:quinone oxidoreductase 1 activity in vivo.

    Science.gov (United States)

    Douglas, Mark; Lim, Alice R; Porter, James R; West, Kip; Pink, Melissa M; Ge, Jie; Wylie, Andrew A; Tibbits, Thomas T; Biggs, Kurtis; Curtis, Michael; Palombella, Vito J; Adams, Julian; Fritz, Christian C; Normant, Emmanuel

    2009-12-01

    IPI-504, a water-soluble ansamycin analogue currently being investigated in clinical trials, is a potent inhibitor of the protein chaperone heat shock protein 90 (Hsp90). Inhibition of Hsp90 by IPI-504 triggers the degradation of important oncogenic client proteins. In cells, the free base of IPI-504 hydroquinone exists in a dynamic redox equilibrium with its corresponding quinone (17-AAG); the hydroquinone form binding 50 times more tightly to Hsp90. It has been proposed recently that the NAD(P)H:quinone oxidoreductase NQO1 can produce the active hydroquinone and could be essential for the activity of IPI-504. Here, we have devised a method to directly measure the intracellular ratio of hydroquinone to quinone (HQ/Q) and have applied this measurement to correlate NQO1 enzyme abundance with HQ/Q ratio and cellular activity of IPI-504 in 30 cancer cell lines. Interestingly, the intracellular HQ/Q ratio was correlated with NQO1 levels only in a subset of cell lines and overall was poorly correlated with the growth inhibitory activity of IPI-504. Although artificial overexpression of NQO1 is able to increase the level of hydroquinone and cell sensitivity to IPI-504, it has little effect on the activity of 17-amino-17-demethoxy-geldanamycin, the major active metabolite of IPI-504. This finding could provide an explanation for the biological activity of IPI-504 in xenograft models of cell lines that are not sensitive to IPI-504 in vitro. Our results suggest that NQO1 activity is not a determinant of IPI-504 activity in vivo and, therefore, unlikely to become an important resistance mechanism to IPI-504 in the clinic.

  3. Malaysia's National Higher Education Research Institute ("IPPTN"): Narrowing the Research-Policy Gap in a Dynamic Higher Education System

    Science.gov (United States)

    Sirat, Morshidi; Azman, Norzaini

    2014-01-01

    Policy decision-making in Malaysia has long used an approach based on intuition, ideology, or conventional wisdom. But as Malaysian society matures within an increasingly complex policy environment, a move toward an evidence-based approach to public policy-making is called for. This paper discusses the experience of the National Higher Education…

  4. Phase II evaluation of IPI-926, an oral Hedgehog inhibitor, in patients with myelofibrosis.

    Science.gov (United States)

    Sasaki, Koji; Gotlib, Jason R; Mesa, Ruben A; Newberry, Kate J; Ravandi, Farhad; Cortes, Jorge E; Kelly, Patrick; Kutok, Jeffery L; Kantarjian, Hagop M; Verstovsek, Srdan

    2015-07-01

    The clinical safety and efficacy of IPI-926 was evaluated in 14 patients with myelofibrosis in a phase II study. Patients received 160 mg IPI-926 orally in continuous 28-day cycles. The median treatment duration was 5.1 months, and all patients had discontinued treatment by 7.5 months. Nine patients discontinued due to lack of response as determined by the treating physician, two after developing acute leukemia and one due to disease progression/loss of response. Twelve patients had slight reductions in spleen size (less than 50% from baseline), but symptoms did not improve consistently. One patient achieved transfusion independence lasting 5 months. Reductions in GLI1 mRNA and protein levels, JAK2V617F allele burden, degree of fibrosis or cytokine levels were observed in some patients, but were not significant when evaluated for the cohort. Low-grade gastrointestinal/liver abnormalities were the most common toxicities. The results did not support continued evaluation of IPI-926 as a monotherapy in myelofibrosis.

  5. Retaspimycin hydrochloride (IPI-504): a novel heat shock protein inhibitor as an anticancer agent.

    Science.gov (United States)

    Hanson, Britt Erika; Vesole, David H

    2009-09-01

    Heat shock proteins are vital to cell survival under conditions of stress. They bind client proteins to assist in protein stabilization, translocation of polypeptides across cell membranes and recovery of proteins from aggregates. Heat shock protein inhibitors are a diverse group of novel agents that have been demonstrated to have pro-apoptotic effects on malignant cells through inhibition of ATP binding on the ATP/ADP-binding pocket of the heat shock protein. Initial development of heat shock protein 90 inhibitors, geldanamycin and 17-AAG, were limited by hepatotoxicity and the need for solvent carrying agents. In contrast, retaspimycin, or IPI-504, a derivative of geldanamycin and 17-AAG, is highly soluble in water and generally well tolerated. In Phase I/II trials, retaspimycin has shown activity in NSCLC and gastrointestinal stromal tumor. The most promising activity was observed in gastrointestinal stromal tumors. Phase I/II trials are currently underway to evaluate the dosing schedules and activity of IPI-504 in breast cancer. Given the in vitro activity in diffuse large B-cell lymphoma, mantle cell lymphoma, melanoma, leukemia and pancreatic cancer, current and future trials are of clinical interest. This article reviews IPI-504 and its utility in a wide variety of cancer phenotypes.

  6. How do Policy and Institutional Settings Shape Opportunities for Community-Based Primary Health Care? A Comparison of Ontario, Québec and New Zealand

    Directory of Open Access Journals (Sweden)

    Tim Tenbensel

    2017-06-01

    Full Text Available Community-based primary health care describes a model of service provision that is oriented to the population health needs and wants of service users and communities, and has particular relevance to supporting the growing proportion of the population with multiple chronic conditions. Internationally, aspirations for community-based primary health care have stimulated local initiatives and influenced the design of policy solutions. However, the ways in which these ideas and influences find their way into policy and practice is strongly mediated by policy settings and institutional legacies of particular jurisdictions. This paper seeks to compare the key institutional and policy features of Ontario, Québec and New Zealand that shape the ‘space available’ for models of community-based primary health care to take root and develop. Our analysis suggests that two key conditions are the integration of relevant health and social sector organisations, and the range of policy levers that are available and used by governments. New Zealand has the most favourable conditions, and Ontario the least favourable. All jurisdictions, however, share a crucial barrier, namely the ‘barbed-wire fence’ that separates funding of medical and ‘non-medical’ primary care services, and the clear interests primary care doctors have in maintaining this fence. Moves in the direction of system-wide community-based primary health care require a gradual dismantling of this fence.

  7. Water, food and markets : household-level impact of irrigation water policies and institutions in northern China

    NARCIS (Netherlands)

    Zhang, L.

    2013-01-01

      Water is increasingly becoming a limiting factor for sustainable economic growth and development, particularly in developing countries. Besides technical innovations, water institution reforms may contribute to improving water allocation decisions. Appropriately designed water institutions

  8. Cornerstones of Student Success: Institutions Yielding High Return on Investment for Underserved Students. Policy Research 2017-5

    Science.gov (United States)

    Holt, Janet K.; Duffy, Daniel Q.

    2017-01-01

    The Illinois Board of Higher Education (IBHE) sought to identify those institutions helping students overcome barriers to college completion and achieve a livable wage. This analysis of Illinois 4-year postsecondary institutions highlights those institutions which fostered degree completion and job success with less debt for underrepresented…

  9. Cornerstones of Student Success: Institutions Yielding High Return on Investment for Underserved Students. Executive Summary. Policy Research 2017-5

    Science.gov (United States)

    Holt, Janet K.; Duffy, Daniel Q.

    2017-01-01

    The Illinois Board of Higher Education (IBHE) sought to identify those institutions helping students overcome barriers to college completion and achieve a livable wage. This analysis of Illinois 4-year postsecondary institutions highlights those institutions which fostered degree completion and job success with less debt for underrepresented…

  10. World bank's role in the electric power sector: Policies for effective institutional, regulatory, and financial reform. World Bank policy paper

    Energy Technology Data Exchange (ETDEWEB)

    1993-01-01

    The policy paper is based on the World Bank Industry and Energy Department's ongoing policy and research work, which (1) examines experiences of industrial countries and the Bank's borrowers in developing their power sectors, (2) analyzes issues facing these sectors, and (3) describes options for dealing with these issues in developing countries. The paper is supported by a large body of research.

  11. [Evaluation of policies in the procedures for food handling to prevent nosocomial infections in general hospitals and public institutions of health in Mexico].

    Science.gov (United States)

    Villanueva Martínez, Sebastián; Macías-Hernández, Alejandro Ernesto; de la Torre-Rosas, Alethse; Polanco González, Carlos

    2014-01-01

    To evaluate the implementation and proper use of policies and procedures for food handling to prevent nosocomial gastrointestinal infections in major General Hospitals and Public Institutions of Health in Mexico. We performed a cross-sectional study of food services in 54 second-level general hospitals from these institutions: Mexican Institute of Social Security (IMSS), Institute of Security and Social Services for State Workers (ISSSTE), and the Ministry of Health (SESA). A questionnaire was made to identify risk factors for food contamination. In the statistical analysis, we determined the relative frequency of food handling complying with the norm; a qualitative analysis was performed using an intentional non-probabilistic sampling, targeting department heads, managers, and operational staff. The qualitative variables were verified through non-parametric tests. From 54 hospitals evaluated, 81% had procedure and operation manuals, 35% prepared and stored food according to NOM-251-SSA1-2009, 52% performed ongoing training, 62% had a record of microbiological analysis done to staff and 81% done to foods, and 31% had first in first out (FIFO) temperature control systems. Second-level health institutions in Mexico have deficiencies in the implementation of norms and procedures to handle, store, and prepare food that can lead to gastrointestinal outbreaks of nosocomial infections in patients, health staff, and visitors. In order to ensure the quality of food preparation for distribution and consumption in hospitals, it is necessary that food services comply with current norms and regulations, updating policies and procedures, and training their staff continuously.

  12. Home-based Palliative Services under Two Local Self-government Institutions of Kerala, India: An Assessment of Compliance with Policy and Guidelines to Local Self-government Institutions.

    Science.gov (United States)

    Jayalakshmi, Rajeev; Suhita, Chatterjee Chopra

    2017-01-01

    In contrast to India's poor performance in palliative and end-of-life care, the state of Kerala has gained considerable attention for its palliative care (PC) policy. This study tried to understand the structure, organization, and delivery of the program currently offered to the rural population, and its conformity to the state's PC policy and guidelines for Local Self-government Institutions (LSGIs). A descriptive research design involving a review of Kerala palliative policy and guidelines for LSGIs was followed by direct field observation and interviews of stakeholders. Two LSGIs in rural Kerala served also by a nongovernmental organization (NGO), were selected. Data were collected from health workers (doctors, nurses, and PC nurses), government stakeholders (LSGI members and representatives of the National Health Mission), and the health workers and officials of NGO. The program in two LSGIs varies considerably in terms of composition of the palliative team, infrastructure and human resource, cost, and type of service provided to the community. A comparative assessment with a nongovernmental service provider shows that the services offered by the LSGIs seemed to be restricted in scope to meet the needs of the resource-stricken community. Compliance with policy guidelines seems to be poor for both the LSGIs. Despite a robust policy, the palliative program lacks a public health approach to end-of-life care. A structural reconfiguration of the delivery system is needed, involving greater state responsibility and political will in integrating PC within a broader social organization of care.

  13. Policy space and the governance of education: transnational influences on institutions and identities in the Netherlands and the UK

    NARCIS (Netherlands)

    Alexiadou, N.; van de Bunt-Kokhuis, S.G.M.

    2013-01-01

    This article presents a comparative analysis of two country-specific cases. The comparative analysis is situated within the broad domain of the changing knowledge economy landscape for educational policy. The two cases examine the transfer, embedding and enactment of policies during the interactions

  14. Assessment of the prognostic indices IPI and FLIPI in patients with mucosa-associated lymphoid tissue lymphoma.

    Science.gov (United States)

    Troch, Marlene; Wöhrer, Stefan; Raderer, Markus

    2010-02-01

    The prognostic values of the International Prognostic Index (IPI) and the Follicular Lymphoma International Prognostic Index (FLIPI) have widely been demonstrated in diffuse large B-cell lymphoma and follicular lymphoma. No attempts to assess their applicability in MALT lymphoma have been made so far. A total of 143 patients with MALT-lymphoma were analysed. Parameters of both IPI and FLIPI were retrospectively assessed and correlated with relapse and time to relapse as markers of clinical course. According to IPI, 96 patients (67%) were classified as low, 22 (15%) low-intermediate, 17 (12%) high-intermediate and 8 (6%) as high risk. FLIPI identified 99 patients (70%) at low risk, 35 (24%) at intermediate and 9 (6%) at high risk. After a median follow-up time of 39.5 months, 123 patients were alive and 46 patients had relapsed (median time to relapse 27 months). IPI significantly correlated with time to relapse, with the typical differentiation into low, low-intermediate and high risk groups. FLIPI divided patients into three groups, but the low and intermediate risk groups showed a similar clinical course. In terms of additional progonostic factors, univariate analysis suggested autoimmune disease and multifocal disease as correlated with relapse. Multiple regression analysis, however, identified only extragastric disease as predictive of relapse (p=0.001). Our data demonstrate that both IPI and FLIPI are able to discriminate prognostic subgroups in patients with MALT-lymphoma. However, the low and intermediate group of the FLIPI did not appear to prognostically differ.

  15. Effective Teaching and Student Engagement in the College Classroom: Using the Instructional Practices Inventory (IPI) as a Tool for Peer Observation and Self-Reflection

    Science.gov (United States)

    Hunzicker, J.; Lukowiak, T.

    2012-01-01

    The authors present initial findings from a collaborative self-study exploring student engagement as a measure of teaching effectiveness. Focused on their college classrooms during one semester, the study pilots a peer observation model of the Instructional Practices Inventory (IPI) (Valentine, 2005). Data collection included IPI codes, anecdotal…

  16. The heat shock protein 90 inhibitor IPI-504 induces KIT degradation, tumor shrinkage, and cell proliferation arrest in xenograft models of gastrointestinal stromal tumors.

    Science.gov (United States)

    Floris, Giuseppe; Debiec-Rychter, Maria; Wozniak, Agnieszka; Stefan, Cristiana; Normant, Emmanuel; Faa, Gavino; Machiels, Kathleen; Vanleeuw, Ulla; Sciot, Raf; Schöffski, Patrick

    2011-10-01

    The activity of the receptor tyrosine kinase KIT is crucial for gastrointestinal stromal tumor (GIST) growth and survival. Imatinib and sunitinib are very effective in advanced GIST, but have no curative potential. The observation that heat shock protein 90 (HSP90) inhibition results in KIT degradation prompted us to assess the efficacy of the HSP90 inhibitor retaspimycin hydrochloride (IPI-504) alone or in combination with imatinib or sunitinib in two GIST xenografts with distinctive KIT mutations. Nude mice were grafted with human GIST carrying KIT exon 13 (GIST-882; n = 59) or exon 11 (GIST-PSW; n = 44) mutations and dosed with imatinib (50 mg/kg twice daily), sunitinib (40 mg/kg once daily), IPI-504 (100 mg/kg 3 times per week), IPI-504 + imatinib, or IPI-504 + sunitinib. We evaluated tumor volume, proliferation and apoptosis, KIT expression and activation, as well as adverse events during treatment. Treatment with IPI-504 alone resulted in tumor regression, proliferation arrest, and induction of tumor necrosis. We documented downregulation of KIT and its signaling cascade in IPI-504-treated animals. Treatment effects were enhanced by combining IPI-504 with imatinib or sunitinib. On histologic examination, liver damage was frequently observed in animals exposed to combination treatments. In conclusion, IPI-504 shows consistent antitumor activity and induces KIT downregulation in GIST, as a single agent, and is more potent in combination with imatinib or sunitinib. The sequence of drug administration in the combination arms warrants further studies.

  17. CD4(+) tumor infiltrating lymphocytes are prognostic and independent of R-IPI in patients with DLBCL receiving R-CHOP chemo-immunotherapy.

    Science.gov (United States)

    Keane, Colm; Gill, Devinder; Vari, Frank; Cross, Donna; Griffiths, Lynn; Gandhi, Maher

    2013-04-01

    Despite the Revised International Prognostic Index's (R-IPI) undoubted utility in diffuse large B-cell lymphoma (DLBCL), significant clinical heterogeneity within R-IPI categories persists. Emerging evidence indicates that circulating host immunity is a robust and R-IPI independent prognosticator, most likely reflecting the immune status of the intratumoral microenvironment. We hypothesized that direct quantification of immunity within lymphomatous tissue would better permit stratification within R-IPI categories. We analyzed 122 newly diagnosed consecutive DLBCL patients treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) chemo-immunotherapy. Median follow-up was 4 years. As expected, the R-IPI was a significant predictor of outcome with 5-year overall survival (OS) 87% for very good, 87% for good, and 51% for poor-risk R-IPI scores (P IPI and LMR. Importantly, within very good/good R-IPI patients, CD4(+) T-cells still distinguished patients with different 5 year OS (high 96% versus low 63%, P = 0.02). These results illustrate the importance of circulating and local intratumoral immunity in DLBCL treated with R-CHOP. Copyright © 2013 Wiley Periodicals, Inc.

  18. [Prognostic significance of NCCN-International Prognostic Index (NCCN-IPI) for patients with peripheral T-cell lymphoma treated with CHOP-based chemotherapy].

    Science.gov (United States)

    Zhang, M C; Xu, P P; Zhong, H J; Zhao, X; Zhao, W L; Cheng, S

    2017-09-14

    Objective: To validate the prognostic value of NCCN-International Prognostic Index (NCCN-IPI) for patients with peripheral T-cell lymphoma (PTCL) treated with CHOP-based chemotherapy. Methods: A retrospective analysis in 162 PTCL patients who were initially diagnosed and treated in Rui Jin Hospital from January 2003 to May 2013 was conducted. Baseline characteristics were collected, and survival analysis was performed according to the IPI and NCCN-IPI model. Results: The estimated 5-year overall survival (OS) rate and progression free survival (PFS) rate were 33% and 20%, with median OS and PFS of 17.0 months and 9.2 months, respectively. Multivariate analysis indicated ECOG score (PFS: HR =2.418, 95% CI 1.535-3.809, P IPI were remarkably higher than the counterparts based on IPI (5-year OS 74% vs 54%, χ (2)=5.041, P =0.025, 5-year PFS 50% vs 38%, χ (2)= 5.295, P =0.021) . NCCN-IPI was outstanding to identify the subgroup of low risk patients with PTCL, who may benefit from conventional chemotherapy such as CHOP or CHOP-like regimen. Conclusion: NCCN-IPI is more powerful for low risk PTCL patients and a strong supplement for IPI.

  19. A modified scoring of the NCCN-IPI is more accurate in the elderly and is improved by albumin and β2 -microglobulin.

    Science.gov (United States)

    Melchardt, Thomas; Troppan, Katharina; Weiss, Lukas; Hufnagl, Clemens; Neureiter, Daniel; Tränkenschuh, Wolfgang; Hopfinger, Georg; Magnes, Teresa; Deutsch, Alexander; Neumeister, Peter; Hackl, Hubert; Greil, Richard; Pichler, Martin; Egle, Alexander

    2015-01-01

    The International Prognostic Index (IPI) has been used for decades in diffuse large B-cell lymphoma (DLBCL). A retrospective cancer registry analysis in North America showed significantly improved results when an enhanced IPI, the National Comprehensive Cancer Network (NCCN)-IPI was applied. This novel score puts more weight on age and high levels of lactate dehydrogenase (LDH). Nevertheless, it remains unclear if these results can be extrapolated to the general population. This retrospective bi-centre analysis included 499 unselected DLBCL patients who were treated with rituximab and anthracycline-based chemoimmunotherapy between 2004 and 2013. In our cohort, the NCCN-IPI was more accurate in identifying patients at low or high risk, despite older age, and more patients with increased LDH. Nevertheless, a modified scoring of the risk factors was required to more accurately identify elderly patients with a very favourable diagnosis, suggesting an impaired value of the original NCCN-IPI in the elderly. Serum β2 -microglobulin and albumin were retained as independent prognostic factors for survival in a multivariate analysis. Our data confirm, for the first time, the superior prognostic power of the NCCN-IPI in an unselected, middle-European cohort. We furthermore propose a modified NCCN-IPI for more accurate prognostication in the elderly. Albumin and β2 -microglobulin levels are likely to add significant information to the NCCN-IPI. © 2014 John Wiley & Sons Ltd.

  20. Formulating A Performance Measurement System using Balanced Score Card in Islamic Philanthropy Institutions

    Directory of Open Access Journals (Sweden)

    Sani A’ieshah Abdullah

    2017-01-01

    Full Text Available The introduction of Balanced Score Card (BSC as one of the management accounting tool to measure the performance of companies in both aspect of financial and non-financial position has been predominantly used since 1992 and had resulted positive energies for the profit making companies. Hence, the extension of the BSC is also required to help the social business organisation in delivering their multiple bottom lines in the most effective ways and provide organisations a mechanism to track their performance holistically through both quantitative and qualitative information. The growing of Islamic Philanthropy Institutions (IPI especially in Malaysia with the objective to promote social development based on the charitable activities has been acknowledged by the society. Therefore, in order to ensure the sustainability of these institutions, a proper measurement system is required to ensure the final goal of the institutions is achievable and successful. Thus, the objective of this paper is to formulate the main indicators and variables that are suitable to measure the IPIs based on BSC system in four main perspectives which are financial perspective, stakeholder’s perspective, internal process perspective and learning and growth perspective. The uniqueness of the establishment of IPIs would require different indicators and variables which are more appropriate as compared with the profit sector organisations. The outcome of this study could provide clear picture and guidelines in designing a proper performance measurement system to be implemented by current IPIs in Malaysia in order to maintain the sustainability and competitiveness of this institutions in future.

  1. Establishment of the International Power Institute

    Energy Technology Data Exchange (ETDEWEB)

    Coles, Julius E.

    2000-04-29

    Building on the two previous trips to Central America last year, International Power Institute (IPI) and its partner Tennessee Valley Infrastructure Group (TVIG) have focused their attention this quarter on project sites in Honduras. TVIG's unit--an Integrated Infrastructure Platform or IIP--combines water and electricity production in a single integrated unit, thereby providing both products at a lower cost than could be attained for each one separately. Because of the unmet demand for clean drinking water and electricity in remote towns throughout the developing world, the need for such units is widespread. Previous visits to Honduras have resulted in strong in-country commercial interest, support in the form of memorandums of understanding by key government agencies, and identification of four prospective project sites for IIP installations. From March 5 to March 15 and with IPI support and participation, representatives from the TVIG, Tennessee Valley Authority (TVA), IPI, and market research firm International Business Initiatives (IBI) conducted an intensive survey of project opportunities in the four communities, to establish how IIPs might help these four communities enhance their economic development, A key aspect of the projects examined is the need to make them economically self-supporting so that they will be viable in the private sector. Summary of specific project site studies follow here, and feasibility studies for the four sites are included as attachments.

  2. Hirschfeld to hooker to herek to high schools: a study of the history and development of GLBT empirical research, institutional policies, and the relationship between the two.

    Science.gov (United States)

    Maher, Michael J; Landini, Kimberly; Emano, Dennis M; Knight, Andrew M; Lantz, Geoffrey D; Parrie, Michael; Pichler, Shaun; Sever, Linda M

    2009-01-01

    Empirical gay, lesbian, bisexual, and transgender (GLBT) research has passed through three stages. Transitions between stages have been caused by an interaction of empirical research and institutional policies. The first period is from the late 1800s up to 1972, when research focused on categorizing homosexuality as a disease, treatments for homosexuality, and then research refuting the disease model. The second period ran from 1972 to approximately 1990, when researchers began to apply the disease model not to GLBT persons, but rather to those having negative attitudes toward homosexuality (homophobia), and researchers began to look at what it was like to be a GLBT person from GLBT persons' perspectives. The third period began in the early 1990s and continues today, when researchers focus on institutions, particularly action research aimed at changing institutions.

  3. Historical institutionalism and economic policymaking ??? determinants of the pattern of economic policy in Brazil, 1930???1960

    OpenAIRE

    Guimar??es, Alexandre Queiroz

    2005-01-01

    From 1930 to 1960, Brazil adopted a pattern of economic policy marked by strong state intervention, high levels of protectionism, disregard of exports and a permissive treatment of inflation. These policies distorted the model of industrialisation and had a negative impact on the prospects for economic development. This article employs a historical institutionalist approach to investigate how the international context, the ideology of the policymakers, the role of the techno...

  4. Springtime Observations of Black Carbon in Arctic Snow across Northern Russia During IPY 2007-2008

    Science.gov (United States)

    Grenfell, T. C.; Warren, S. G.; Radionov, V. F.; Kogan, S. E.

    2008-12-01

    Black carbon (BC) in snow at ppb levels can significantly reduce the visible and near IR albedo. The effect is important for climate in regions where large areas of snow-covered surfaces are exposed to significant sunlight. The initial study of Clarke and Noone (1985) across the western Arctic in 1983-84 indicated albedo reduction of about 0-4 percent due to BC; however, their survey did not include results from the Russian Arctic. During April and May of 2007 and 2008, as part of the International Polar Year Program, two cooperative U.S.-Russian expeditions obtained the first set of BC observations at selected sites near the communities of Naryan Mar, Vorkuta, Dikson, Khatanga, Tiksi, Chersky, Bilibino, and Pevek, spanning almost the entire northern coastal zone of Russia. Samples were also obtained near Yakutsk, a sub-Arctic region of boreal forest with a severe winter climate. This time period was chosen to provide access to the full winter snowpack just prior to the onset of spring melt. This project is a critical component of a repeat and extension of the original 1985 survey, which now includes sites spanning the entire Arctic. A discussion of this work is the topic of an invited presentation by S. G. Warren in session "Snow and Ice Impurities as Climate Forcing Agents and Records" (C04). This project required access to restricted border regions of Russia, which was facilitated by the political prominence of the IPY program in the Russian government. Generous logistical assistance and advice were provided by Dr. V. N. Makarov of the Permafrost Institute in Yakutsk, Dr. Sergei Zimov of the Northeast Scientific Station at Chersky, and the Hydrometeorological Service at Pevek. Commercial air travel to the above-mentioned communities, in conjunction with local transportation, provided access to the observation sites, which were located at distances of 15-100 km from local sources to sample background levels of BC. At each site, snow samples and density profiles

  5. Science Policy at the Wrong Scale and Without Adequate Political Institutions: Parallels between the U.S. 19th Century and the 21st Century Global Contexts

    Science.gov (United States)

    McCurdy, K. M.

    2012-12-01

    The Constitution of the United States is a document for economic development written by people wary of government failure at the extremes, whether too heavy handed a central government or too loose a confederation. The strong central government favored by Hamilton, Industrialists and later by forward thinking men of the 19th century created a discontinuity wherein government institutions designed to facilitate agriculture were incapable of regulating corporations operating on a national scale, which made mineral and other natural resource exploitation needed to support industrialization enormously profitable. At the same time, Agriculturalists and other conservative citizens sought to control the economy by protecting their rural interests and power. The political institutional power remained with states as agriculturalists and industrialists struggled for economic superiority in the 19th century. As Agriculture moved west, Science warned of the dangers of extending Homesteading regulations into arid regions to no avail. The west was settled in townships without concern for watersheds, carrying capacity, or climatic variability. Gold seekers ignored the consequences of massive hydraulic mining techniques. The tension resident in the Constitution between strong local control of government (states' rights) and a strong central government (nationalism) provided no institutional context to resolve mining problems or other 19th century policy problems linked to rapid population expansion and industrialization. Environmental protection in the late 20th century has been the last wave of nationalized policy solutions following the institution-building blueprint provided by electoral successes in the Progressive, New Deal, and Great Society eras. Suddenly in the 21st century, scientific warnings of dangers again go unheeded, this time as evidence of global warming mounts. Again, tension in policy making exists in all political arenas (executive, legislative and judicial at

  6. Imposto sobre Produtos Industrializados (IPI): seletividade e não - cumulatividade

    OpenAIRE

    Cella, João Nelson

    2006-01-01

    O presente estudo visa analisar as normas constitucionais da seletividade e da não-cumulatividade do Imposto sobre Produtos Industrializados (IPI), tributo de competência da União, que pelas suas características, procura alcançar os ideais de justiça fiscal nos impostos indiretos. Por essa razão, seguimos, inicialmente, uma rota que entendemos obrigatória, que é da interpretação no Direito Tributário. Percorreremos o Sistema Constitucional Tributário, apresentando um brev...

  7. Innovations for ISS Plug-In Plan (IPiP) Operations

    Science.gov (United States)

    Moore, Kevin D.

    2013-01-01

    Limited resources and increasing requirements will continue to influence decisions on ISS. The ISS Plug-In Plan (IPiP) supports power and data for utilization, systems, and daily operations through the Electrical Power System (EPS) Secondary Power/Data Subsystem. Given the fluid launch schedule, the focus of the Plug-In Plan has evolved to anticipate future requirements by judicious development and delivery of power supplies, power strips, Alternating Current (AC) power inverters, along with innovative deployment strategies. A partnership of ISS Program Office, Engineering Directorate, Mission Operations, and International Partners poses unique solutions with existing on-board equipment and resources.

  8. Ex-Post Critical Evaluations of Energy Policies in Malaysia from 1970 to 2010: A Historical Institutionalism Perspective

    Directory of Open Access Journals (Sweden)

    Amir F. N. Abdul-Manan

    2015-03-01

    Full Text Available Ex-post evaluations of energy policies in Malaysia between 1970 and 2010 were conducted. The developments of energy policies in Malaysia were traced from the early 1970s with the introduction of the country’s first energy-related policy all the way to 2010 with the country’s first endeavour towards a biobased energy system. Analyses revealed that many of the policies were either: (1 directly responding to changes in global/domestic socioeconomic and political events, or (2 provided visions to guide developments of the energy sector in alignment with the country’s growth agenda. Critical examinations of the country’s actual energy consumptions during these 40 years were also conducted to evaluate the efficacy of these energy-related policies. Three noteworthy successes in Malaysia’s energy landscape are: (1 the formation of PETRONAS as the national oil and gas company; (2 reduction of country’s over-reliance on oil as a single source of energy by significantly growing the production and use of natural gas in a short span of time; and (3 creation of a thriving oil and gas value chain and ecosystem in the country. However, the country is still critically dependent on scarce petroleum resources, despite having an abundance of renewable reserves. Progress towards renewable energy has been too little and too slow.

  9. Incomplete Markets and Imperfect Institutions: Some Challenges Posed by Trust for Contemporary Health Care and Health Policy.

    Science.gov (United States)

    Schlesinger, Mark; Gray, Bradford H

    2016-08-01

    As contemporary health policy promotes evidence-based practices using targeted incentives, policy makers may lose track of vital aspects of care that are difficult to measure. For more than a half century, scholars have recognized that these latter aspects play a crucial role in high-quality care and equitable health system performance but depend on the potentially frail reed of providers' trustworthiness: that is, their commitment to facets and outcomes of care not easily assessed by external parties. More recently, early experience with pay for performance in health settings suggests that enhancing financial rewards for the measurable undermines providers' commitment to the unmeasurable, degrading the trustworthiness of their practices. Reformers have looked to revised professional norms or reorganized practice arrangements to bolster the intrinsic motivations required for trustworthiness. We suggest here that these responses are likely to prove inadequate. We propose that they be complemented by a renewed policy-making commitment to nonprofit ownership among health care providers, insurers, and integrated delivery systems. We identify some of the concerns raised in the past with ownership-based policies and propose a set of responses. If these are pursued in combination, they hold the promise of a sustainable ownership-based policy reform for the United States. Copyright © 2016 by Duke University Press.

  10. Water, food and markets : household-level impact of irrigation water policies and institutions in northern China

    NARCIS (Netherlands)

    Zhang, L.

    2013-01-01

    Water is increasingly becoming a limiting factor for sustainable economic growth and development, particularly in developing countries. Besides technical innovations, water institution reforms may contribute to improving water allocation decisions. Appropriately designed water

  11. [Institutional support as a method of analysis-intervention in the context of public health policies: the experience in a general hospital].

    Science.gov (United States)

    Barros, Maria Elizabeth Barros de; Guedes, Carla Ribeiro; Roza, Monica Maria Raphael

    2011-12-01

    The article addresses the elaboration of a method for analysis/intervention in the sphere of public health policies. It describes the introduction of the National Humanization Policy of the Unified Health System (SUS) in a general hospital. It proposes institutional support expressed as a method for doing things that seeks the creation of group action, work process analysis and involves examining work management methods. It relies on promotion of health, which implies the production of subjects. The promotion of health is a networking process that involves individuals, work processes, knowledge and power. The challenge of supporting this network is to foster the exercise of the role of individuals and summon the inherent creative potential of life for the construction of new ways of work management that are not new forms of subjection. The study aims to show that by means of institutional support it is possible to bring to the fore the forces involved in the promotion of health and thereby summon the groups for an analysis of its implications. The effects produced indicate that this is a powerful strategy for the intervention of work processes within the scope of public health policies.

  12. Northwest Energy Policy Project. Institutional constraints and opportunities study module V, Report on tasks 4, 5, 6, and 7. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1977-01-01

    State governments, along with their counties, cities, public utility districts, and other local units have important responsibilities in the energy field. Their institutions and policy processes offer both constraints and opportunities in the exercise of these responsibilities. The purpose of this study is to explore them in four rather different aspects: Task 4, Public Participation; Task 5, State Rate-Making; Task 6, Siting Energy Facilities; Task 7, Unconventional Energy Sources. Public participation is basic to democratic systems, which strive to develop policies in accord with, or at least not adverse to, the wishes of the people; participation in decision making can be in the market place as well as in the voting booth or the halls of government. The state public utility commissions set rates for investor-owned utilities which supply some 23% of the electricity consumed in Washington, 72% in Oregon, and 92% in Idaho. Rates for electricity supplied by publicly-owned systems are established by their elected governing bodies. For these and other reasons there are many and widely varying rates charged in the Northwest. Siting of energy facilities presents a widely varying framework in the Northwest states also. Task 7 focuses on the institutional constraints and opportunities the states confront in seeking alternatives to the traditional pattern of looking to greater supplies of the conventional sources. Geothermal energy appears to have potential mainly as a heat source in this region. Energy conservation is considered as a policy alternative, although not an energy source. (MCW)

  13. Institutional entrepreneurship:

    DEFF Research Database (Denmark)

    Gretzinger, Susanne

    2018-01-01

    of agents or organisations in the policy arena. The present chapter understands institutional entrepreneurship as the process of changing institutionalised practices. Based on a literature review, it describes the triggers, activities and potential effects of institutional entrepreneurs. The chapter......Institutional entrepreneurship pays specific attention to the process and outcomes of agents who are willing and capable of changing institutions. It has some common ground with the political entrepreneur, a concept that proposes change in norms and institutions because of commitment and activities...... concludes by tentatively arguing that political entrepreneurs can be institutional entrepreneurs, but institutional entrepreneurship can be considered as the broader concept that incorporates strategies and visions as well as interpretative-discursive power into the conceptual framework....

  14. A European and Swedish perspective on ICT – policies and strategies in education. National and institutional pathways: crossings, blind alleys and uphill slopes

    Directory of Open Access Journals (Sweden)

    Henrik Hansson

    2004-04-01

    Full Text Available This paper aims at answering the following questions: 1. What general goals do politicians in Europe express in national policy documents for the integration of information and communication technology (ICT in their education systems? To develop that theme further we explored the situation in our own country Sweden as a case. 2. What policies and strategies for ICT in education do leaders of Swedish higher education institutions develop? 3. How do Swedish national priorities and academic institutional interests match? The globalisation of education forces different value systems to meet. There is on the national level highly different political values on what kind of education system to prefer – the Scandinavian model and the American model are two extremes. There are also very different values inherent in higher education institutions, the academia, - compared with the values and visions held by the political leaders. These value differences between and within countries are elaborated and discussed. A Swedish, Scandinavian and European perspective is adopted, but a wider international outlook is also given. It is suggested that the value conflicts, often not explicit, understood or recognised, are one of the major inhibitors for systemic change. The direction of change cannot be taken for granted – the driving forces pull in opposing directions. Different visions of the future struggle to be fulfilled.

  15. Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926).

    Science.gov (United States)

    Tremblay, Martin R; Lescarbeau, André; Grogan, Michael J; Tan, Eddy; Lin, Grace; Austad, Brian C; Yu, Lin-Chen; Behnke, Mark L; Nair, Somarajan J; Hagel, Margit; White, Kerry; Conley, James; Manna, Joseph D; Alvarez-Diez, Teresa M; Hoyt, Jennifer; Woodward, Caroline N; Sydor, Jens R; Pink, Melissa; MacDougall, John; Campbell, Matthew J; Cushing, Jill; Ferguson, Jeanne; Curtis, Michael S; McGovern, Karen; Read, Margaret A; Palombella, Vito J; Adams, Julian; Castro, Alfredo C

    2009-07-23

    Recent evidence suggests that blocking aberrant hedgehog pathway signaling may be a promising therapeutic strategy for the treatment of several types of cancer. Cyclopamine, a plant Veratrum alkaloid, is a natural product antagonist of the hedgehog pathway. In a previous report, a seven-membered D-ring semisynthetic analogue of cyclopamine, IPI-269609 (2), was shown to have greater acid stability and better aqueous solubility compared to cyclopamine. Further modifications of the A-ring system generated three series of analogues with improved potency and/or solubility. Lead compounds from each series were characterized in vitro and evaluated in vivo for biological activity and pharmacokinetic properties. These studies led to the discovery of IPI-926 (compound 28), a novel semisynthetic cyclopamine analogue with substantially improved pharmaceutical properties and potency and a favorable pharmacokinetic profile relative to cyclopamine and compound 2. As a result, complete tumor regression was observed in a Hh-dependent medulloblastoma allograft model after daily oral administration of 40 mg/kg of compound 28.

  16. Concordia, Antarctica, seismic experiment for the International Polar Year (CASE-IPY

    Directory of Open Access Journals (Sweden)

    Alessia Maggi

    2014-06-01

    Full Text Available The CASE-IPY project, part of the larger POLENET initiative of geophysical observations for the International Polar Year, was built on our extensive experience of running seismological stations in Antarctica, both on rock sites (Dumont d’Urville station, and directly on the ice plateau (Concordia station. For CASE-IPY, we deployed 8 temporary seismic stations on the Antarctic plateau: 3 situated near Concordia itself (starting 2008, and the other 5 regularly spaced between Concordia and Vostok (2010-2012, following the maximum in ice topography. The technical problems we have encountered in our field deployments were essentially due to a combination of extreme environmental conditions and isolation of deployment sites. The 3 stations near Concordia were used as test sites to experiment different solutions, and to converge on a design for the 5 main stations. Results from the nearest stations, which transmit data regularly to Concordia, are very promising. The data recorded by our stations will be distributed widely in the scientific community. We expect them to be exploited essentially for structural studies involving Antarctica itself (its ice-cap, crust and lithosphere via receiver functions, noise correlation, and surface-wave tomography, but also for studies of the Earth’s core.

  17. Polarjugend.de - an IPY Education and Outreach Project of the German Youth Steering Committee

    Science.gov (United States)

    Sachs, T.; Kaiser, B.; Richter, A.; Schofield, R.; Lantuit, H.; Salmon, R.; Haase, D.

    2007-12-01

    The online network polarjugend.de is a project being initiated by the German Youth Steering Committee for the International Polar Year (GYSC) in cooperation with the International Youth Steering Committe and the IPY Education and Outreach. Two goals integral to the YSC are firstly the networking of young polar researchers across all disciplines early in their careers to enable collaboration, and secondly for this network to be involved in outreach to other youth. To meet these two aims with a project coordinated by the youth for the youth, the German YSC has created an online platform in German to facilitate the collaboration among high-school students, teachers and young polar researchers in and outside the classroom. The GYSC coordinates presentations and discussions at high schools throughout Germany by networking teachers and researchers and providing educational material and resources. The GYSC makes available brief online presentations and articles for further use in the classroom. An event calendar provides teachers and students with subject-relevant information on the Polar Regions. An online discussion forum considers student questions dealing with polar issues. The project aims at reducing the language barrier of polar education and outreach activities for a German- speaking audience by providing polar-related information and further means of communication specifically in German. The project is designed to continue beyond the timeline of the IPY, and the GYSC is confident that it will exert a lasting effect on German high-school education and the integration and discussion of Polar issues into the curriculum.

  18. Political Incongruity between Students' Ideological Identity and Stance on Specific Public Policies in a Predominantly White Southeastern State Institution

    Science.gov (United States)

    Coles, Jeremy T.; Carstens, Brittany A.; Wright, Jennifer M.; Williams, Robert L.

    2015-01-01

    The study determined whether or not a predominantly Caucasian sample (N = 187) attending a southeastern state's major public university embraced political policies consistent with their self-identified political ideology. The findings showed that the highest percentage of students identified with a conservative ideology and that a much lower…

  19. The Effect of Monetary Policy on Exchange Rates during Currency Crises; The Role of Debt, Institutions and Financial Openness

    NARCIS (Netherlands)

    S.C.W. Eijffinger (Sylvester); B. Goderis

    2007-01-01

    textabstractThis paper examines the effect of monetary policy on the exchange rate during currency crises. Using data for a number of crisis episodes between 1986 and 2004, we find strong evidence that raising the interest rate: (i) has larger adverse balance sheet effects and is therefore less

  20. The Effect of Monetary Policy on Exchange Rates During Currency Crises : The Role of Debt, Institutions and Financial Openness

    NARCIS (Netherlands)

    Eijffinger, S.C.W.; Goderis, B.V.G.

    2007-01-01

    This paper examines the effect of monetary policy on the exchange rate during currency crises. Using data for a number of crisis episodes between 1986 and 2004, we find strong evidence that raising the interest rate: (i) has larger adverse balance sheet effects and is therefore less effective in

  1. A Study of the Effect of Information Security Policies on Information Security Breaches in Higher Education Institutions

    Science.gov (United States)

    Waddell, Stanie Adolphus

    2013-01-01

    Many articles within the literature point to the information security policy as one of the most important elements of an effective information security program. Even though this belief is continually referred to in many information security scholarly articles, very few research studies have been performed to corroborate this sentiment. Doherty and…

  2. A New Agenda for Teaching Public Administration and Public Policy in Brazil: Institutional Opportunities and Educational Reasons

    Science.gov (United States)

    Gomes, Sandra; Almeida, Lindijane S. B.; Lucio, Magda L.

    2016-01-01

    This article discusses the reasons and teaching objectives of an array of new undergraduate courses on public administration and public policy management which have emerged recently in Brazil. While in 2001 there were only two undergraduate courses teaching formal public administration in the country, by 2015, they had risen to 40, and also…

  3. Leveraging the water-energy-food nexus for a sustainability transition: Institutional and policy design choices in a fragmented world (Invited)

    Science.gov (United States)

    Aggarwal, R.

    2013-12-01

    Given the critical - but often subtle - feedbacks between water, energy, and food security, a nexus approach that integrates management and governance across sectors and scales is increasingly being advocated in research and policy circles. As a first step, such an approach calls for an integrated multi-disciplinary assessment of the externalities across sectors and tradeoffs involved in enhancing security in one sector on the other sectors. Recent research efforts have focused on understanding these tradeoffs, say, through estimating the energy costs of expanding irrigation for greater food security; or estimating the embodied land and water costs in increased energy production. While such efforts have increased awareness about the inter-connectedness of such issues, the fundamental question of how such an understanding influences decision-making and how it can lead to coordinated action towards a transition to more sustainable pathways still remains largely unanswered. The long legacy of sectoral organization of political and bureaucratic structures has led to a fragmentary policy and institutional landscape, on which cross-sectoral public action and coordination poses several challenges. Moreover, poorly defined property rights, imperfect or absent markets, and uncertainty about resource dynamics imply that economic signals about relative scarcity in one sector are not necessarily clear to decision makers in the other sectors. In this study, we examine these issues related to water-energy food nexus in the context of semi-arid groundwater irrigated regions of western and southern India. Using a social-ecological systems framework, we begin by characterizing some of the key inter-dependencies among food, water, and energy at the farm household, village and state level. We then examine the factors that influence decision-making at these levels, and the extent to which these decisions internalize the externalities. Specifically, we examine the role of energy

  4. An enhanced International Prognostic Index (NCCN-IPI) for patients with diffuse large B-cell lymphoma treated in the rituximab era.

    Science.gov (United States)

    Zhou, Zheng; Sehn, Laurie H; Rademaker, Alfred W; Gordon, Leo I; Lacasce, Ann S; Crosby-Thompson, Allison; Vanderplas, Ann; Zelenetz, Andrew D; Abel, Gregory A; Rodriguez, Maria A; Nademanee, Auayporn; Kaminski, Mark S; Czuczman, Myron S; Millenson, Michael; Niland, Joyce; Gascoyne, Randy D; Connors, Joseph M; Friedberg, Jonathan W; Winter, Jane N

    2014-02-06

    The International Prognostic Index (IPI) has been the basis for determining prognosis in patients with aggressive non-Hodgkin lymphoma (NHL) for the past 20 years. Using raw clinical data from the National Comprehensive Cancer Network (NCCN) database collected during the rituximab era, we built an enhanced IPI with the goal of improving risk stratification. Clinical features from 1650 adults with de novo diffuse large B-cell lymphoma (DLBCL) diagnosed from 2000-2010 at 7 NCCN cancer centers were assessed for their prognostic significance, with statistical efforts to further refine the categorization of age and normalized LDH. Five predictors (age, lactate dehydrogenase (LDH), sites of involvement, Ann Arbor stage, ECOG performance status) were identified and a maximum of 8 points assigned. Four risk groups were formed: low (0-1), low-intermediate (2-3), high-intermediate (4-5), and high (6-8). Compared with the IPI, the NCCN-IPI better discriminated low- and high-risk subgroups (5-year overall survival [OS]: 96% vs 33%) than the IPI (5 year OS: 90% vs 54%), respectively. When validated using an independent cohort from the British Columbia Cancer Agency (n = 1138), it also demonstrated enhanced discrimination for both low- and high-risk patients. The NCCN-IPI is easy to apply and more powerful than the IPI for predicting survival in the rituximab era.

  5. The pre-clinical absorption, distribution, metabolism and excretion properties of IPI-926, an orally bioavailable antagonist of the hedgehog signal transduction pathway.

    Science.gov (United States)

    Smith, Sherri; Hoyt, Jennifer; Whitebread, Nigel; Manna, Joseph; Peluso, Marisa; Faia, Kerrie; Campbell, Veronica; Tremblay, Martin; Nair, Somarajan; Grogan, Michael; Castro, Alfredo; Campbell, Matthew; Ferguson, Jeanne; Arsenault, Brendan; Nevejans, Jylle; Carter, Bennett; Lee, John; Dunbar, Joi; McGovern, Karen; Read, Margaret; Adams, Julian; Constan, Alexander; Loewen, Gordon; Sydor, Jens; Palombella, Vito; Soglia, John

    2013-10-01

    1. IPI-926 is a novel semisynthetic cyclopamine derivative that is a potent and selective Smoothened inhibitor that blocks the hedgehog signal transduction pathway. 2. The in vivo clearance of IPI-926 is low in mouse and dog and moderate in monkey. The volume of distribution is high across species. Oral bioavailability ranges from moderate in monkey to high in mouse and dog. Predicted human clearance using simple allometry is low (24 L h(-1)), predicted volume of distribution is high (469 L) and predicted half-life is long (20 h). 3. IPI-926 is highly bound to plasma proteins and has minimal interaction with human α-1-acid glycoprotein. 4. In vitro metabolic stability ranges from stable to moderately stable. Twelve oxidative metabolites were detected in mouse, rat, dog, monkey and human liver microsome incubations and none were unique to human. 5. IPI-926 is not a potent reversible inhibitor of CYP1A2, 2C8, 2C9 or 3A4 (testosterone). IPI-926 is a moderate inhibitor of CYP2C19, 2D6 and 3A4 (midazolam) with KI values of 19, 16 and 4.5 µM, respectively. IPI-926 is both a substrate and inhibitor (IC50 = 1.9 µM) of P-glycoprotein. 6. In summary, IPI-926 has desirable pre-clinical absorption, distribution, metabolism and excretion properties.

  6. A phase 1 study of IPI-504 (retaspimycin hydrochloride) in patients with relapsed or relapsed and refractory multiple myeloma.

    Science.gov (United States)

    Siegel, David; Jagannath, Sundar; Vesole, David H; Borello, Ivan; Mazumder, Amitabha; Mitsiades, Constantine; Goddard, Jill; Dunbar, Joi; Normant, Emmanuel; Adams, Julian; Grayzel, David; Anderson, Kenneth C; Richardson, Paul

    2011-12-01

    Abstract A phase 1 study of IPI-504 (retaspimycin hydrochloride) administered intravenously twice weekly for 2 weeks at 22.5, 45, 90, 150, 225, 300 or 400 mg/m(2) followed by 10 days off-treatment was conducted to determine the safety and maximum tolerated dose (MTD) of IPI-504 in patients with relapsed or relapsed/refractory multiple myeloma (MM). Anti-tumor activity and pharmacokinetics were also evaluated. Eighteen patients (mean age 60.5 years; median 9 prior therapies) were enrolled. No dose-limiting toxicities (DLTs) were reported for IPI-504 doses up to 400 mg/m(2). The most common treatment-related adverse event was grade 1 infusion site pain (four patients). All other treatment-related events were assessed as grade 1 or 2 in severity. The area under the curve (AUC) increased with increasing dose, and the mean half-life was approximately 2-4 h for IPI-504 and its metabolites. Four patients had stable disease, demonstrating modest single-agent activity in relapsed or relapsed/refractory MM.

  7. Evaluation of and Information Concerning Individually Prescribed Instruction in Mathematics (IPI); 1967-1968, Friends School, Wilmington, Delaware.

    Science.gov (United States)

    Research for Better Schools, Inc., Philadelphia, PA.

    A self-evaluation of Individually Prescribed Instruction (IPI) in mathematics made by Friends School (Wilmington, Delaware) is justified and presented in this report. First, the establishment of six objectives (student independence, mastery of basic skills and concepts, achievement rate and level; teacher diagnostic functions, prescriptive…

  8. An Inter-Projection Interpolation (IPI) Approach with Geometric Model Restriction to Reduce Image Dose in Cone Beam CT (CBCT).

    Science.gov (United States)

    Zhang, Hong; Kong, Fengchong; Ren, Lei; Jin, Jian-Yue

    2014-09-01

    Cone beam computed tomography (CBCT) imaging is a key step in image guided radiation therapy (IGRT) to improve tumor targeting. The quality and imaging dose of CBCT are two important factors. However, X-ray scatter in the large cone beam field usually induces image artifacts and degrades the image quality for CBCT. A synchronized moving grid (SMOG) approach has recently been proposed to resolve this issue and shows great promise. However, the SMOG technique requires two projections in the same gantry angle to obtain full information due to signal blockage by the grid. This study aims to develop an inter-projection interpolation (IPI) method to estimate the blocked image information. This approach will require only one projection in each gantry angle, thus reducing the scan time and patient dose. IPI is also potentially suitable for sparse-view CBCT reconstruction to reduce the imaging dose. To be compared with other state-of-the-art spatial interpolation (called inpainting) methods in terms of signal-to-noise ratio (SNR) on a Catphan and head phantoms, IPI increases SNR from 15.3dB and 12.7dB to 29.0dB and 28.1dB, respectively. The SNR of IPI on sparse-view CBCT reconstruction can achieve from 28dB to 17dB for undersample projection sets with gantry angle interval varying from 1 to 3 degrees for both phantoms.

  9. Report of Comparison between Iowa Test of Basic Skills-Form 4 and IPI Continuum 1967-68.

    Science.gov (United States)

    Weinberger, Jo Ann

    Due to the problems inherent in using a norm-reference test such as the Iowa Test of Basic Skills (ITBS) to determine pupil achievement, a comparison of ITBS with the Individually Prescribed Instruction (IPI) continuum and placement tests was undertaken. This yielded the following conclusions: Of the 136 items on test 1-A Arithmetic Concepts, 14…

  10. The Fourth Year of IPI Mathematics at Minneapolis Hall School: 1972-73. A Title I ESEA Project.

    Science.gov (United States)

    Johnson, Lary

    The Individually Prescribed Instruction (IPI) mathematics project at Hall Elementary School in Minneapolis completed its fourth year of operation in June 1973. The program is organized on a continuum of 415 math skills grouped into eight levels according to increased difficulty. Students progress through the continuum at their own rate as they…

  11. Base Input - Enrollment and Graduation Data for Naval Postgraduate School for the School of Business and Public Policy, Meyer Institute of Systems Engineering, and PhD Grads by curriculum by year.

    OpenAIRE

    2005-01-01

    Graphs of Base Input - Enrollment and Graduation Data for Naval Postgraduate School for the School of Business and Public Policy, Meyer Institute of Systems Engineering, and PhD Grads by curriculum by year.

  12. Actualizing panarchy within environmental policy: mechanisms for tweaking institutional hierarchies to mimic the social-ecological systems they manage

    Science.gov (United States)

    Environmental law plays a key role in shaping approaches to sustainability. In particular, the role of legal instruments, institutions, and the relationship of law to the inherent variability in social-ecological systems is critical. Sustainability likely must occur via the insti...

  13. Factors, Practices, and Policies Influencing Students' Upward Transfer to Baccalaureate-Degree Programs and Institutions: A Mixed Methods Analysis

    Science.gov (United States)

    LaSota, Robin Rae

    2013-01-01

    My dissertation utilizes an explanatory, sequential mixed-methods research design to assess factors influencing community college students' transfer probability to baccalaureate-granting institutions and to present promising practices in colleges and states directed at improving upward transfer, particularly for low-income and first-generation…

  14. Health Manpower Credentialing: Legal Implications of Institutional Licensure. Health Manpower Policy Discussion Paper Series No.: C3.

    Science.gov (United States)

    Crane, Stephen

    The objective of this analysis is to outline in broad fashion the current trends and issues in the licensure of health manpower and to contrast two proposed alternative systems of credentialing that focus on licensure of health care institutions instead of individual health care providers. The argument of the analysis is that the current system of…

  15. Students as Stakeholders in the Policy Context of the European Standards and Guidelines for Quality Assurance in Higher Education Institutions

    NARCIS (Netherlands)

    Logermann, Frauke; Leisyte, Liudvika; Curaj, Adrian; Matei, Liviu; Pricopie, Remus; Salmi, Jamil; Scott, Peter

    2015-01-01

    The European Standard and Guidelines for Quality Assurance (ESG) of 2005 can be defined as one of the major Bologna documents aimed at furthering the role of students as stakeholders in internal quality assurance processes at higher education institutions (HEIs). Still little is known about

  16. Institutional changes and industrial policy in the petroleum sector; Mudanca institucional e politica industrial no setor de petroleo

    Energy Technology Data Exchange (ETDEWEB)

    Furtado, Andre Tosi

    2007-07-01

    This article poses a position that the main responsibility for the institutional change in petroleum and gas sectors was due to the opportunity to rise the investment volumes to attend the final consumer and to give value to the country potential resources.

  17. A Critique of Institutional Inequalities in Higher Education: (Or an Alternative to Hypocrisy for Higher Educational Policy)

    Science.gov (United States)

    Leathwood, Carole

    2004-01-01

    This article seeks to apply Adam Swift's (2003) critique of private and selective schooling to higher education in the UK. The higher education sector in this country is highly differentiated, with high status, research-led elite institutions at the top of the university hierarchy, and newer universities, with far lower levels of funding and…

  18. A framework for an institutional high level security policy for the processing of medical data and their transmission through the Internet.

    Science.gov (United States)

    Ilioudis, C; Pangalos, G

    2001-01-01

    specific implementation environment. When implemented in specific environments, these principles and guidelines must also be complemented by measures, which are more specific. Even when a High Level Security Policy already exists in an institution, it is advisable that the management of the Health Care Establishment periodically revisits it to see whether it should be modified or augmented.

  19. Changes in Canadian Agricultural Marketing and Trade Policy: The Impacts of New Trade Rules and New Institutions

    OpenAIRE

    Veeman, Michele M.

    1996-01-01

    The Canada-United States Free Trade Agreement (CUSTA) and the subsequent North American Free Trade Agreement (NAFTA) have contributed to increasing concentration of agricultural trade between the United States and Canada. This has heightened bilateral trade tensions and trade conflicts for numbers of Canadian farm products. These conflicts, and the need to accommodate domestic marketing policies to the obligations of the General Agreement on Tariffs and Trade (GATT) and its successor, the Wor...

  20. Behavioral economics, neuroeconomics, and climate change policy: baseline review for the garrison institute initiative on climate change

    OpenAIRE

    John M. Gowdy

    2010-01-01

    In spite of the increasing scientific certainty that the earth's climate is warming and that human activity is partially responsible, public willingness to take steps to reduce greenhouse gas emissions seems to be decreasing. How can the scientific consensus as to the urgency of the climate change problem be conveyed to the general public in such a way as to support greenhouse gas abatement policies and to actually change behavior? This essay explores the standard economic approach to environ...

  1. Need for a comprehensive, consistently applied national hepatitis B vaccination policy for healthcare workers in higher educational institutions: a case study from South Africa.

    Science.gov (United States)

    Fernandes, L; Burnett, R J; François, G; Mphahlele, M J; Van Sprundel, M; De Schryver, A

    2013-03-01

    Hepatitis B virus (HBV) is transmitted by infected blood and other body fluids, placing healthcare workers (HCWs) and student HCWs at increased risk of HBV infection through occupational exposure. To establish the existence, content and implementation of hepatitis B (HB) vaccination policies for student HCWs being trained at higher educational institutions (HEIs) in South Africa. Self-administered structured questionnaires were sent to 23 nursing colleges and 11 universities in South Africa that train doctors, nurses or dentists. Twelve (35%) questionnaires were returned. Ten HEIs had a policy consisting mainly of recommendations given to students at registration. Nine HEIs made HB vaccinations available, with four HEIs covering the cost through student fees. Seven HEIs did not require a record of previous vaccination. Six HEIs did not accept non-responders (NRs), three HEIs would only accept an NR after receiving a second three-dose vaccination series and counselling, six HEIs regarded an HBV carrier as infectious, and 10 HEIs would accept HBV carriers as students. The low response rate makes it difficult to generalize the results, but may suggest a lack of an HB vaccination policy for student HCWs at non-responding HEIs. Policies of responding HEIs regarding HB vaccination, HBV carriage and response to HB vaccination were variable, sometimes inappropriate and not sufficiently comprehensive to protect student HCWs against occupationally acquired HBV. This emphasizes the need for a comprehensive, consistently applied, nationally coordinated vaccination policy to ensure that student HCWs receive proper protection against HBV infection. Copyright © 2012 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.

  2. Antitumor activity and molecular effects of the novel heat shock protein 90 inhibitor, IPI-504, in pancreatic cancer.

    Science.gov (United States)

    Song, Dongweon; Chaerkady, Raghothama; Tan, Aik Choon; García-García, Elena; Nalli, Anuradha; Suárez-Gauthier, Ana; López-Ríos, Fernando; Zhang, Xian Feng; Solomon, Anna; Tong, Jeffrey; Read, Margaret; Fritz, Christian; Jimeno, Antonio; Pandey, Akhilesh; Hidalgo, Manuel

    2008-10-01

    Targeting Hsp90 is an attractive strategy for anticancer therapy because the diversity and relevance of biological processes are regulated by these proteins in most cancers. However, the role and mode of action of Hsp90 inhibitors in pancreatic cancer has not been studied. This study aimed to assess the antitumor activity of the Hsp90 inhibitor, IPI-504, in pancreatic cancer and to determine the biological effects of the agent. In vitro, we show that pharmacologic inhibition of Hsp90 by IPI-504 exerts antiproliferative effects in a panel of pancreatic cancer cells in a dose- and time-dependent manner. In pancreatic cancer xenografts obtained directly from patients with pancreas cancer, the agent resulted in a marked suppression of tumor growth. Although known Hsp90 client proteins were significantly modulated in IPI-504-treated cell line, no consistent alteration of these proteins was observed in vivo other than induction of Hsp70 expression in the treated xenografted tumors. Using a proteomic profiling analysis with isotope tags for relative and absolute quantitation labeling technique, we have identified 20 down-regulated proteins and 42 up-regulated proteins on IPI-504 treatment.tumor growth Identical changes were observed in the expression of the genes coding for these proteins in a subset of proteins including HSPA1B, LGALS3, CALM1, FAM84B, FDPS, GOLPH2, HBA1, HIST1H1C, HLA-B, and MARCKS. The majority of these proteins belong to the functional class of intracellular signal transduction, immune response, cell growth and maintenance, transport, and metabolism. In summary, we show that IPI-504 has potent antitumor activity in pancreatic cancer and identify potential pharmacologic targets using a proteomics and gene expression profiling.

  3. Integrating gender medicine into the workplace health and safety policy in the scientific research institutions: a mandatory task.

    Science.gov (United States)

    Giammarioli, Anna Maria; Siracusano, Alessandra; Sorrentino, Eugenio; Bettoni, Monica; Malorni, Walter

    2012-01-01

    Gender medicine is a multi-faceted field of investigation integrating various aspects of psycho-social and biological sciences but it mainly deals with the impact of the gender on human physiology, pathophysiology, and clinical features of diseases. In Italy, the Decree Law 81/2008 recently introduced the gender issue in the risk assessment at the workplaces. This review briefly describes our current knowledge on gender medicine and on the Italian legislation in risk management. Public or private scientific institutions should be the first to pay attention to the safety of their workers, who are simultaneously subjected to biological, chemical and physical agents. Main tasks of risk management in scientific research institutions are here analyzed and discussed in a gender perspective.

  4. Integrating gender medicine into the workplace health and safety policy in the scientific research institutions: a mandatory task

    Directory of Open Access Journals (Sweden)

    Anna Maria Giammarioli

    2012-01-01

    Full Text Available BACKGROUND: Gender medicine is a multi-faceted field of investigation integrating various aspects of psycho-social and biological sciences but it mainly deals with the impact of the gender on human physiology, pathophysiology, and clinical features of diseases. In Italy, the Decree Law 81/2008 recently introduced the gender issue in the risk assessment at the workplaces. AIMS: This review briefly describes our current knowledge on gender medicine and on the Italian legislation in risk management. CONCLUSIONS: Public or private scientific institutions should be the first to pay attention to the safety of their workers, who are simultaneously subjected to biological, chemical and physical agents. Main tasks of risk management in scientific research institutions are here analyzed and discussed in a gender perspective.

  5. Preventing and controlling human noroviruses in South Carolina long-term care facilities: An analysis of institutional policies and procedures.

    Science.gov (United States)

    Jayasekara, Lalani; Leone, Cortney M; Sharp, Julia; Fraser, Angela

    2016-01-01

    Long-term care (LTC) facilities are the number one setting for human norovirus (HuNoV) outbreaks in the United States (60%). We aimed to determine alignment of policies and procedures in LTC facilities in South Carolina with Centers for Disease Control and Prevention (CDC) recommendations and to determine readability based on Federal Plain Language Guidelines and Microsoft Word readability statistics. Most facilities (n = 21) had procedures for hand hygiene, but recommendations for handwashing events and duration varied greatly. Less than half (n = 11) had separate procedures devoted to HuNoV outbreak control. Fifteen required disinfection of bodily fluids. Seven had procedures for exclusion of sick staff during an outbreak. Both hand hygiene and bodily fluid cleanup procedures had low mean scores for readability. Mean Flesch Reading Ease and Flesch-Kincaid Grade Level for both procedures were in the range of difficult to understand. Most LTC policies and procedures were not consistent with CDC recommendations for HuNoV. Moreover, readability of all procedures is needed so LTC workers can easily understand and implement prevention and control procedures. Published by Elsevier Inc.

  6. Public participation in the social policies and services of the community of Madrid: the institutional system / El sistema institucional de participación ciudadana en las políticas y los servicios sociales de la comunidad de Madrid

    Directory of Open Access Journals (Sweden)

    Gema Pastor Albaladejo

    2013-10-01

    Full Text Available This article analyzes the Community of Madrid’s institutional public participation system, to determine whether the different existing formal mechanisms (regulatory framework and permanent participation organisms have an appropriate institutional design to ensure that citizens have access to, and the ability to intervene in, those deliberative processes that may in some way influence the regional social policies and services.

  7. TTI Phase 2 Institutional Support: The Institute of Economic Affairs ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    TTI Phase 2 Institutional Support: The Institute of Economic Affairs, Ghana. This funding will help strengthen the Institute of Economic Affairs' (IEA-Ghana) role as a credible public policy institution by enhancing its ability to provide high-quality, influential, and policy-relevant research. About the Institute of Economic Affairs

  8. Comparison of conventional prognostic indices in patients older than 60 years with diffuse large B-cell lymphoma treated with R-CHOP in the US Intergroup Study (ECOG 4494, CALGB 9793): consideration of age greater than 70 years in an elderly prognostic index (E-IPI).

    Science.gov (United States)

    Advani, Ranjana H; Chen, Haiyan; Habermann, Thomas M; Morrison, Vicki A; Weller, Edie A; Fisher, Richard I; Peterson, Bruce A; Gascoyne, Randy D; Horning, Sandra J

    2010-10-01

    To assess if immunochemotherapy influenced the prognostic value of IPI in elderly diffuse large B-cell lymphoma (DLBCL) patients, we evaluated the performance of the standard International Prognostic Index (IPI) and following modifications: age adjusted (AA)-IPI, revised (R)-IPI, and an elderly IPI with age cut-off 70 years (E-IPI) in patients > 60 years treated with RCHOP (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone). In 267 patients, by IPI/AA-IPI 60% were high-intermediate, 53% high and 12% low risk. With R-IPI, 60% were poor risk and none very good risk. Using E-IPI, 45% were high-intermediate/high risk and 27% low risk. No differences in outcome were seen in the low/low-intermediate groups with IPI/AA-IPI. For E-IPI, failure-free survival (FFS) and overall survival (OS) were significantly different for low/low-intermediate groups. No differences were detected in the four indices with model fit/discrimination measures; however, E-IPI ranked highest. For elderly R-CHOP treated patients, distribution of IPI/AA-IPI skewed toward high/high-intermediate risk with no differences in FFS/OS between low/low-intermediate risk. In contrast, with E-IPI, more are classified as low risk with significant differences in FFS/OS for low-intermediate compared to low risk. The R-IPI does not identify a very good risk group, thus minimizing its utility in this population. The prognostic discrimination provided by the E-IPI for low and low-intermediate elderly DLBCL patients needs validation by other datasets. © 2010 Blackwell Publishing Ltd.

  9. Mind the gap in SEA: An institutional perspective on why assessment of synergies amongst climate change mitigation, adaptation and other policy areas are missing

    International Nuclear Information System (INIS)

    Vammen Larsen, Sanne; Kørnøv, Lone; Wejs, Anja

    2012-01-01

    This article takes its point of departure in two approaches to integrating climate change into Strategic Environmental Assessment (SEA): Mitigation and adaptation, and in the fact that these, as well as the synergies between them and other policy areas, are needed as part of an integrated assessment and policy response. First, the article makes a review of how positive and negative synergies between a) climate change mitigation and adaptation and b) climate change and other environmental concerns are integrated into Danish SEA practice. Then, the article discusses the implications of not addressing synergies. Finally, the article explores institutional explanations as to why synergies are not addressed in SEA practice. A document analysis of 149 Danish SEA reports shows that only one report comprises the assessment of synergies between mitigation and adaptation, whilst 9,4% of the reports assess the synergies between climate change and other environmental concerns. The consequences of separation are both the risk of trade-offs and missed opportunities for enhancing positive synergies. In order to propose explanations for the lacking integration, the institutional background is analysed and discussed, mainly based on Scott's theory of institutions. The institutional analysis highlights a regulatory element, since the assessment of climate change synergies is underpinned by legislation, but not by guidance. This means that great focus is on normative elements such as the local interpretation of legislation and of climate change mitigation and adaptation. The analysis also focuses on how the fragmentation of the organisation in which climate change and SEA are embedded has bearings on both normative and cultural–cognitive elements. This makes the assessment of synergies challenging. The evidence gathered and presented in the article points to a need for developing the SEA process and methodology in Denmark with the aim to include climate change in the assessments in

  10. Public access and use of health research: an exploratory study of the National Institutes of Health (NIH) Public Access Policy using interviews and surveys of health personnel.

    Science.gov (United States)

    O'Keeffe, Jamie; Willinsky, John; Maggio, Lauren

    2011-11-21

    In 2008, the National Institutes of Health (NIH) Public Access Policy mandated open access for publications resulting from NIH funding (following a 12-month embargo). The large increase in access to research that will take place in the years to come has potential implications for evidence-based practice (EBP) and lifelong learning for health personnel. This study assesses health personnel's current use of research to establish whether grounds exist for expecting, preparing for, and further measuring the impact of the NIH Public Access Policy on health care quality and outcomes in light of time constraints and existing information resources. In all, 14 interviews and 90 surveys of health personnel were conducted at a community-based clinic and an independent teaching hospital in 2010. Health personnel were asked about the research sources they consulted and the frequency with which they consulted these sources, as well as motivation and search strategies used to locate articles, perceived level of access to research, and knowledge of the NIH Public Access Policy. In terms of current access to health information, 65% (57/88) of the health personnel reported being satisfied, while 32% (28/88) reported feeling underserved. Among the sources health personnel reported that they relied upon and consulted weekly, 83% (73/88) reported turning to colleagues, 77% (67/87) reported using synthesized information resources (eg, UpToDate and Cochrane Systematic Reviews), while 32% (28/88) reported that they consulted primary research literature. The dominant resources health personnel consulted when actively searching for health information were Google and Wikipedia, while 27% (24/89) reported using PubMed weekly. The most prevalent reason given for accessing research on a weekly basis, reported by 35% (31/88) of survey respondents, was to help a specific patient, while 31% (26/84) were motivated by general interest in research. The results provide grounds for expecting the NIH

  11. Detection of antibodies specific for HLA-A,B,C,DR,DQ and DP by the erythrocyte antibody rosette inhibition (EAI) and immune phagocytosis inhibition (IPI) tests.

    Science.gov (United States)

    Faust, A; Neppert, J

    1987-08-24

    Two methods for the detection of murine monoclonal antibodies against determinants of the human major histocompatibility complex (MHC) were evaluated. These methods are based upon the function of Fc receptors; the erythrocyte antibody rosette inhibition test (EAI test) using B-lymphocytes and the immune phagocytosis inhibition test (IPI test) using monocytes. Compared to the EAI test the IPI test was technically easier and gave better discrimination between positive and negative results. The inhibition by antibodies of monomorphic class II MHC or polymorphic HLA-DR antigens was stronger in the IPI than in the EAI test. Antibodies against HLA-DQ and DP antigens evoked inhibition only using the EAI test. Using IgG derived from placenta in different dilutions the detection of its anti-HLA antibodies was more readily achieved in the IPI test than in the EAI test.

  12. Discovery of a Selective Phosphoinositide-3-Kinase (PI3K)-γ Inhibitor (IPI-549) as an Immuno-Oncology Clinical Candidate.

    Science.gov (United States)

    Evans, Catherine A; Liu, Tao; Lescarbeau, André; Nair, Somarajan J; Grenier, Louis; Pradeilles, Johan A; Glenadel, Quentin; Tibbitts, Thomas; Rowley, Ann M; DiNitto, Jonathan P; Brophy, Erin E; O'Hearn, Erin L; Ali, Janid A; Winkler, David G; Goldstein, Stanley I; O'Hearn, Patrick; Martin, Christian M; Hoyt, Jennifer G; Soglia, John R; Cheung, Culver; Pink, Melissa M; Proctor, Jennifer L; Palombella, Vito J; Tremblay, Martin R; Castro, Alfredo C

    2016-09-08

    Optimization of isoquinolinone PI3K inhibitors led to the discovery of a potent inhibitor of PI3K-γ (26 or IPI-549) with >100-fold selectivity over other lipid and protein kinases. IPI-549 demonstrates favorable pharmacokinetic properties and robust inhibition of PI3K-γ mediated neutrophil migration in vivo and is currently in Phase 1 clinical evaluation in subjects with advanced solid tumors.

  13. Do agricultural subsidies crowd out or stimulate rural credit market institutions? The case of EU Common Agricultural Policy

    Directory of Open Access Journals (Sweden)

    Jan and Katarina Szegenyova Pokrivcak

    2012-11-01

    Full Text Available In this paper we estimate the impact of agricultural subsidies granted under the European Union’s Common Agricultural Policy (CAP on bank loans extended to farms. According to our theoretical analysis, subsidies may either stimulate or crowd out bank loans depending on the timing of subsidies, severity of credit constraint, type of subsidies and bank loans, and the relative cost of internal and external financing. In empirical analysis we use the Farm Accountancy Data Network (FADN farm level panel data for the period 1995-2007. We employ the fixed effects and generalised method of moment (GMM models. The estimated results suggest that (i big farms tend to use subsidies to increase long-term loans, whereas small farms tend to use subsidies to obtain short-term loans; (ii subsidies tend to crowd out short-term loans for big farms and long-term loans for small farms; (iii when controlling for the endogeneity, the crowding out effect becomes smaller, but the positive causal effect of subsidies on bank loans remains significant.

  14. Characteristics and determinants of knowledge transfer policies at universities and public institutions in medical research--protocol for a systematic review of the qualitative research literature.

    Science.gov (United States)

    Jahn, Rosa; Müller, Olaf; Bozorgmehr, Kayvan

    2015-08-19

    Universities, public institutions, and the transfer of knowledge to the private sector play a major role in the development of medical technologies. The decisions of universities and public institutions regarding the transfer of knowledge impact the accessibility of the final product, making it easier or more difficult for consumers to access these products. In the case of medical research, these products are pharmaceuticals, diagnostics, or medical procedures. The ethical dimension of access to these potentially lifesaving products is apparent and distinguishes the transfer of medical knowledge from the transfer of knowledge in other areas. While the general field of technology transfer from academic and public to private actors is attracting an increasing amount of scholarly attention, the specifications of knowledge transfer in the medical field are not as well explored. This review seeks to provide a systematic overview and analysis of the qualitative literature on the characteristics and determinants of knowledge transfer in medical research and development. The review systematically searches the literature for qualitative studies that focus on knowledge transfer characteristics and determinants at medical academic and public research institutions. It aims at identifying and analyzing the literature on the content and context of knowledge transfer policies, decision-making processes, and actors at academic and public institutions. The search strategy includes the databases PubMed, Web of Science, ProQuest, and DiVa. These databases will be searched based on pre-specified search terms. The studies selected for inclusion in the review will be critically assessed for their quality utilizing the Qualitative Research Checklist developed by the Clinical Appraisal Skills Programme. Data extraction and synthesis will be based on the meta-ethnographic approach. This review seeks to further the understanding of the kinds of transfer pathways that exist in medical

  15. Profiling Hsp90 differential expression and the molecular effects of the Hsp90 inhibitor IPI-504 in high-grade glioma models.

    Science.gov (United States)

    Di, Kaijun; Keir, Stephen T; Alexandru-Abrams, Daniela; Gong, Xing; Nguyen, Howard; Friedman, Henry S; Bota, Daniela A

    2014-12-01

    Retaspimycin hydrochloride (IPI-504), an Hsp90 (heat shock protein 90) inhibitor, has shown activity in multiple preclinical cancer models, such as lung, breast and ovarian cancers. However, its biological effects in gliomas and normal brain derived cellular populations remain unknown. In this study, we profiled the expression pattern of Hsp90α/β mRNA in stable glioma cell lines, multiple glioma-derived primary cultures and human neural stem/progenitor cells. The effects of IPI-504 on cell proliferation, apoptosis, motility and expression of Hsp90 client proteins were evaluated in glioma cell lines. In vivo activity of IPI-504 was investigated in subcutaneous glioma xenografts. Our results showed Hsp90α and Hsp90β expression levels to be patient-specific, higher in high-grade glioma-derived primary cells than in low-grade glioma-derived primary cells, and strongly correlated with CD133 expression and differentiation status of cells. Hsp90 inhibition by IPI-504 induced apoptosis, blocked migration and invasion, and significantly decreased epidermal growth factor receptor levels, mitogen-activated protein kinase and/or Akt activities, and secretion of vascular endothelial growth factor in glioma cell lines. In vivo study showed that IPI-504 could mildly attenuate tumor growth in immunocompromised mice. These findings suggest that targeting Hsp90 by IPI-504 has the potential to become an active therapeutic strategy in gliomas in a selective group of patients, but further research into combination therapies is still needed.

  16. The chronic lymphocytic leukemia international prognostic index (CLL-IPI) predicts time to first treatment in early CLL: Independent Validation in a Prospective Cohort of Early Stage Patients

    Science.gov (United States)

    Molica, Stefano; Shanafelt, Tait D.; Giannarelli, Diana; Gentile, Massimo; Mirabelli, Rosanna; Cutrona, Giovanna; Levato, Luciano; Di Renzo, Nicola; Di Raimondo, Francesco; Musolino, Caterina; Angrilli, Francesco; Famà, Angelo; Recchia, Anna Grazia; Chaffee, Kari G.; Neri, Antonino; Kay, Neil E.; Ferrarini, Manlio; Morabito, Fortunato

    2016-01-01

    The chronic lymphocytic leukemia International Prognostic Index (CLL-IPI) combines 5 parameters (age, clinical stage, TP53 status [normal vs. del(17p) and/or TP53 mutation], IGHV mutational status, serum β2-microglobulin) to predict survival and time-to-first-treatment (TTFT) in CLL patients. We performed an observational study in 337 prospectively collected, Binet stage A patients to validate the ability of the CLL-IPI to predict TTFT in an independent cohort of early stage CLL patients. The CLL-IPI score stratified Binet stage A patients into three subgroups with different outcome. Since the CLL-IPI was originally developed to predict survival, we next investigated the optimal cut-off score to predict TTFT in Binet stage A patients. Recursive partitioning analysis identified three subsets with scores of 0 (n=139), 1 (n=90), and ≥ 2(n=108). The probability of remaining free from therapy 5 years after diagnosis was 85%, 67% and 46% in these three categories (PIPI scoring for TTFT was subsequently validated in an independent cohort of Binet A patients from the Mayo Clinic (n=525). The ability of either original or optimized CLL-IPI to predict TTFT was equivalent to other prognostic models specifically designed for this endpoint (2011 MDACC score and O-CLL1 score). Although originally developed to predict suvival, the CLL-IPI is useful for predicting TTFT in early stage CLL patients. PMID:27465919

  17. Consequences of the discontinuation of the International Protein Index (IPI) database and its substitution by the UniProtKB "complete proteome" sets.

    Science.gov (United States)

    Griss, Johannes; Martín, María; O'Donovan, Claire; Apweiler, Rolf; Hermjakob, Henning; Vizcaíno, Juan Antonio

    2011-11-01

    The International Protein Index (IPI) database has been one of the most widely used protein databases in MS proteomics approaches. Recently, the closure of IPI in September 2011 was announced. Its recommended replacement is the new UniProt Knowledgebase (UniProtKB) "complete proteome" sets, launched in May 2011. Here, we analyze the consequences of IPI's discontinuation for human and mouse data, and the effect of its substitution with UniProtKB on two levels: (i) data already produced and (ii) newly performed experiments. To estimate the effect on existing data, we investigated how well IPI identifiers map to UniProtKB accessions. We found that 21% of human and 10% of mouse identifiers do not map to UniProtKB and would thus be "lost." To investigate the impact on new experiments, we compared the theoretical search space (i.e. the tryptic peptides) of both resources and found that it is decreased by 14.0% for human and 8.9% for mouse data through IPI's closure. An analysis on the experimental evidence for these "lost" peptides showed that the vast majority has not been identified in experiments available in the major proteomics repositories. It thus seems likely that the search space provided by UniProtKB is of higher quality than the one currently provided by IPI. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  18. Monitoring of the Polar Stratospheric Clouds formation and evolution in Antarctica in August 2007 during IPY with the MATCH method applied to lidar data

    Science.gov (United States)

    Montoux, Nadege; David, Christine; Klekociuk, Andrew; Pitts, Michael; di Liberto, Luca; Snels, Marcel; Jumelet, Julien; Bekki, Slimane; Larsen, Niels

    2010-05-01

    The project ORACLE-O3 ("Ozone layer and UV RAdiation in a changing CLimate Evaluated during IPY") is one of the coordinated international proposals selected for the International Polar Year (IPY). As part of this global project, LOLITA-PSC ("Lagrangian Observations with Lidar Investigations and Trajectories in Antarctica and Arctic, of PSC") is devoted to Polar Stratospheric Clouds (PSC) studies. Indeed, understanding the formation and evolution of PSC is an important issue to quantify the impact of climate changes on their frequency of formation and, further, on chlorine activation and subsequent ozone depletion. In this framework, three lidar stations performed PSC observations in Antarctica during the 2006, 2007, and 2008 winters: Davis (68.58°S, 77.97°E), McMurdo (77.86°S, 166.48°E) and Dumont D'Urville (66.67°S, 140.01°E). The data are completed with the lidar data from CALIOP ("Cloud-Aerosol Lidar with Orthogonal Polarization") onboard the CALIPSO ("Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observation") satellite. Lagrangian trajectory calculations are used to identify air masses with PSCs sounded by several ground-based lidar stations with the same method, called MATCH, applied for the first time in Arctic to study the ozone depletion with radiosoundings. The evolution of the optical properties of the PSCs and thus the type of PSCs formed (supercooled ternary solution, nitric acid trihydrate particles or ice particles) could thus be linked to the thermodynamical evolution of the air mass deduced from the trajectories. A modeling with the microphysical model of the Danish Meteorological Institute allows assessing our ability to predict PSCs for various environmental conditions. Indeed, from pressure and temperature evolution, the model allows retrieving the types of particles formed as well as their mean radii, their concentrations and could also simulate the lidar signals. In a first step, a case in August 2007 around 17-18 km, involving

  19. Cancer multidisciplinary team meetings in practice: Results from a multi-institutional quantitative survey and implications for policy change.

    Science.gov (United States)

    Rankin, Nicole M; Lai, Michelle; Miller, Danielle; Beale, Philip; Spigelman, Allan; Prest, Gabrielle; Turley, Kim; Simes, John

    2018-02-01

    Multidisciplinary care is advocated as best practice in cancer care. Relatively little is documented about multidisciplinary team (MDT) meeting functioning, decision making and the use of evidence to support decision making in Australia. This descriptive study aimed to examine team functioning, the role of team meetings and evidence use in MDTs whose institutions are members of Sydney Catalyst Translational Cancer Research Centre. We designed a structured 40-item survey instrument about topics that included meeting purpose, organization, resources and documentation; caseload estimates; use of evidence and quality assurance; patient involvement and supportive care needs; and open-ended items about the MDTs strengths and weaknesses. Participants were invited to participate via email and the survey was administered online. Data were analyzed using descriptive and comparative statistics. Thirty-seven MDTs from seven hospitals participated (100% response) and represented common (70%) and rare tumor groups (30%). MDT meeting purpose was reported as treatment (100%) or diagnostic decision making (88%), or for education purposes (70%). Most MDTs based treatment decisions on group consensus (92%), adherence to clinical practice guidelines (57%) or other evidence-based medicine sources (33%). The majority of MDTs discussed only a proportion of new patients at each meeting emphasizing the importance of educational aspects for other cases. Barriers exist in the availability of data to enable audit and reflection on evidence-based practice. MDT strengths included collaboration and quality discussion about patients. MDT meetings focus on treatment decision making, with group consensus playing a significant role in translating research evidence from guidelines into clinical decision making. With a varying proportion of patients discussed in each MDT meeting, a wider audit of multidisciplinary care would enable more accurate assessments of whether treatment recommendations are in

  20. Role of Immune Microenvironmental Factors for Improving the IPI-related Risk Stratification of Aggressive B Cell Lymphoma.

    Science.gov (United States)

    Gong, Yi; Chen, Rui; Zhang, Xi; Zou, Zhong Min; Chen, Xing Hua

    2017-07-01

    To investigate the risk stratification of aggressive B cell lymphoma using the immune microenvironment and clinical factors. A total of 127 patients with aggressive B cell lymphoma between 2014 and 2015 were enrolled in this study. CD4, Foxp3, CD8, CD68, CD163, PD-1, and PD-L1 expression levels were evaluated in paraffin-embedded lymphoma tissues to identify their roles in the risk stratification. Eleven factors were identified for further evaluation using analysis of variance, chi-square, and multinomial logistic regression analysis. Significant differences in 11 factors (age, Ann Arbor stage, B symptom, ECOG performance status, infiltrating CD8+ T cells, PD-L1 expression, absolute blood monocyte count, serum lactate dehydrogenase, serum iron, serum albumin, and serum β2-microglobulin) were observed among patient groups stratified by at least two risk stratification methods [International Prognostic Index (IPI), revised IPI, and NCCN-IPI models] (P < 0.05). Concordance rates were high (81.4%-100.0%) when these factors were used for the risk stratification. No difference in the risk stratification results was observed with or without the Ann Arbor stage data. We developed a convenient and inexpensive tool for use in risk stratification of aggressive B cell lymphomas, although further studies on the role of immune microenvironmental factors are needed. Copyright © 2017 The Editorial Board of Biomedical and Environmental Sciences. Published by China CDC. All rights reserved.

  1. IMPACT ANALYSIS OF LEGISLATIVE AND INSTITUTIONAL FRAMEWORK ON THE POLICY FOR REGIONAL DEVELOPMENT IN THE LIGHT OF THE REGIONAL OPERATIONAL PROGRAMME

    Directory of Open Access Journals (Sweden)

    Popescu (Stîngaciu Ana-Maria

    2012-12-01

    Full Text Available The analysis of the administrative capacity of institutions in the regional development starts from the analysis of the existing framework for the implementation of regional politics in Romania and studies the extent to what the structures and competencies were regionally enlarged as to contribute in the regional development. The basic hypothesis considered for such analysis had in view the fact that the differences recorded with respect to the implementation capacity of the regional development policy are caused by the various levels of the administrative capacity of the national, regional and local institutions existent in Romania. Although the regional development activity is, both centrally and regionally, dominated by the Regional Operational Programmme 2007-2013 (ROP implementation, significant activity also exists outside the ROP, but only regionally. The regional strategies incorporate to a great extent the strategic objectives established nationally, being coordinated with the national financing instruments for economic, social and territorial development. The undertaking degree of responsibilities regarding the objectives fulfillment of the regional development policy is relatively low both regionally and locally, and the main indicator which contributes in sustaining this conclusion is the absence of an adequate level regarding the property holding on certain strategies and also the methodological lack of strategies. Nationally, the current activity of Ministry of Regional Development and Tourism in the field of regional development totally overlaps the management activity of ROP. The management of structural funds 2007-2013 granted through ROP deals with various situations in which, due to the fact that the Law of regional development remained behind the legislation for the structural instruments implementation in Romania, additional resources are necessary to be granted in order to be found solutions through other types of

  2. i-PI: A Python interface for ab initio path integral molecular dynamics simulations

    Science.gov (United States)

    Ceriotti, Michele; More, Joshua; Manolopoulos, David E.

    2014-03-01

    Recent developments in path integral methodology have significantly reduced the computational expense of including quantum mechanical effects in the nuclear motion in ab initio molecular dynamics simulations. However, the implementation of these developments requires a considerable programming effort, which has hindered their adoption. Here we describe i-PI, an interface written in Python that has been designed to minimise the effort required to bring state-of-the-art path integral techniques to an electronic structure program. While it is best suited to first principles calculations and path integral molecular dynamics, i-PI can also be used to perform classical molecular dynamics simulations, and can just as easily be interfaced with an empirical forcefield code. To give just one example of the many potential applications of the interface, we use it in conjunction with the CP2K electronic structure package to showcase the importance of nuclear quantum effects in high-pressure water. Catalogue identifier: AERN_v1_0 Program summary URL: http://cpc.cs.qub.ac.uk/summaries/AERN_v1_0.html Program obtainable from: CPC Program Library, Queen’s University, Belfast, N. Ireland Licensing provisions: GNU General Public License, version 3 No. of lines in distributed program, including test data, etc.: 138626 No. of bytes in distributed program, including test data, etc.: 3128618 Distribution format: tar.gz Programming language: Python. Computer: Multiple architectures. Operating system: Linux, Mac OSX, Windows. RAM: Less than 256 Mb Classification: 7.7. External routines: NumPy Nature of problem: Bringing the latest developments in the modelling of nuclear quantum effects with path integral molecular dynamics to ab initio electronic structure programs with minimal implementational effort. Solution method: State-of-the-art path integral molecular dynamics techniques are implemented in a Python interface. Any electronic structure code can be patched to receive the atomic

  3. The Selective Phosphoinoside-3-Kinase p110δ Inhibitor IPI-3063 Potently Suppresses B Cell Survival, Proliferation, and Differentiation.

    Science.gov (United States)

    Chiu, Honyin; Mallya, Sharmila; Nguyen, Phuongthao; Mai, Annie; Jackson, Leandra V; Winkler, David G; DiNitto, Jonathan P; Brophy, Erin E; McGovern, Karen; Kutok, Jeffery L; Fruman, David A

    2017-01-01

    The class I phosphoinoside-3-kinases (PI3Ks) are important enzymes that relay signals from cell surface receptors to downstream mediators driving cellular functions. Elevated PI3K signaling is found in B cell malignancies and lymphocytes of patients with autoimmune disease. The p110δ catalytic isoform of PI3K is a rational target since it is critical for B lymphocyte development, survival, activation, and differentiation. In addition, activating mutations in PIK3CD encoding p110δ cause a human immunodeficiency known as activated PI3K delta syndrome. Currently, idelalisib is the only selective p110δ inhibitor that has been FDA approved to treat certain B cell malignancies. p110δ inhibitors can suppress autoantibody production in mouse models, but limited clinical trials in human autoimmunity have been performed with PI3K inhibitors to date. Thus, there is a need for additional tools to understand the effect of pharmacological inhibition of PI3K isoforms in lymphocytes. In this study, we tested the effects of a potent and selective p110δ inhibitor, IPI-3063, in assays of B cell function. We found that IPI-3063 potently reduced mouse B cell proliferation, survival, and plasmablast differentiation while increasing antibody class switching to IgG1, almost to the same degree as a pan-PI3K inhibitor. Similarly, IPI-3063 potently inhibited human B cell proliferation in vitro . The p110γ isoform has partially overlapping roles with p110δ in B cell development, but little is known about its role in B cell function. We found that the p110γ inhibitor AS-252424 had no significant impact on B cell responses. A novel dual p110δ/γ inhibitor, IPI-443, had comparable effects to p110δ inhibition alone. These findings show that p110δ is the dominant isoform mediating B cell responses and establish that IPI-3063 is a highly potent molecule useful for studying p110δ function in immune cells.

  4. The International University Courses on Permafrost (IUCP): an IPY Education Initiative From the International Permafrost Association (IPA)

    Science.gov (United States)

    Prick, A.; Christiansen, H. H.

    2006-12-01

    Worldwide, only very few dedicated permafrost courses exist at university level today. This significantly limits the development of new permafrost researchers. Therefore, the International Permafrost Association (IPA) has developed an overview of International University Courses on Permafrost (IUCP), as part of its participation in the IPY. This polar-related educational program covers cross-cutting activities of the four core IPY-IPA endorsed cluster projects that constitute the IPY Permafrost Programme: Permafrost Observatory Project: A Contribution to the Thermal State of Permafrost (TSP; Project 50); Antarctic and sub-Antarctic Permafrost, Periglacial and Soil Environments (ANTPAS; Project 33); Arctic Circumpolar Coastal Observatory Network (ACCO-Net; Project 90); Carbon Pools in Permafrost Regions (CAPP; Project 373). The IUCP collects information about existing and new IPY permafrost courses worldwide, to encourage a broad international student participation in the existing courses. All courses dealing with permafrost and periglacial geomorphology within the science and engineering disciplines and organized in 2007 to 2009 in both hemispheres qualify for IUCP. Some courses are exclusively field-based and take place in various polar regions, offering students a unique opportunity to gather field experience. Other courses are theoretical and classroom-based or include only limited time in the field. All course levels are taken into account, from undergraduate to doctorate level; the IPA also encourages young professional participation in the IUCP. IPA- IPY education coordinators in each country are providing relevant information. IUCP course information is presented on the IPA webpage. The use of web resource and search tools allow easy access to course contents. The IUCP course numbers by countries as by August 2006 is: Argentina (1), Belgium (1), Canada (29), China (11), Denmark (1), France (2), Japan (7), Mongolia (1), Netherlands (4), New Zealand (1

  5. Prognostication of diffuse large B-cell lymphoma in the molecular era: moving beyond the IPI.

    Science.gov (United States)

    Wight, Joel C; Chong, Geoffrey; Grigg, Andrew P; Hawkes, Eliza A

    2018-03-26

    Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease with variable outcomes. Despite the majority of patients being cured with combination chemoimmunotherapy, up to 30% eventually succumb to the disease. Until recently, baseline prognostic assessment has centred on the International Prognostic Index (IPI), although this index is yet to impact strongly on treatment choice. Molecular features such as cell of origin, MYC and BCL-2 genetic alterations and protein overexpression were identified over a decade ago, yet their prognostic value is still not fully elucidated. Adding complexity are the plethora of new clinical, biological and molecular prognostic markers described in the recent literature, most of which lack independent validation, likely act as surrogate markers for those already in common use and have yet to substantially impact on therapeutic decision making. This review comprehensively assesses the value of individual prognostic markers in the clinical setting and their potential to predict response to novel agents, and ways to optimise their use in future research. Copyright © 2018 Elsevier Ltd. All rights reserved.

  6. Ice Stories: An Educational Collaboration between the Exploratorium and IPY Scientists.

    Science.gov (United States)

    Mary, M. K.

    2007-12-01

    The Exploratorium, a renowned interactive science museum in San Francisco, has launched a major NSF-funded public education project to highlight research in the Arctic and Antarctic during the International Polar Year. "Ice Stories" will partner museum media and web producers with polar scientists working in the field to bring their research to the Internet and museum audiences via live Webcasts, video clips, blogs, podcasts, and other media platforms. To prepare scientists for their role as field correspondents, the Exploratoirum will train a cohort of 20- 30 young investigators in media collection, production and narrative story telling during an intensive one-week workshop in San Francisco. The museum will curate the polar field reports, and other IPY news and education events, into a continuously updated Web portal on the Exploratorium's award-winning Website and highlight the ongoing research in museum programming, floor demonstrations, and exhibits. These unique collaborations between formal and informal science can serve as a model for other partnerships during major scientific endeavors beyond the International Polar Year.

  7. Effects of an IPyC Crack on the Mechanical Behavior of the TRISO Coating Layers

    International Nuclear Information System (INIS)

    Cho, Moon-Sung; Kim, Y. M.; Lee, Y. W.; Jeong, K. C.; Kim, Y. K.; Oh, S. C.

    2008-01-01

    The fundamental design of a gas-cooled reactor relies on an understanding of the behavior of a coated particle fuel. KAERI, which has been carrying out the Korean VHTR (Very High Temperature modular gas cooled Reactor) Project since 2004, is developing a fuel performance analysis code for a VHTR named COPA (COated Particle fuel Analysis). COPA predicts temperatures, stresses, a fission gas release and failure probabilities of a coated particle fuel in normal operating conditions. COPA code consists of nine sub-codes and every sub-code has its own functions and models. Each sub-code can be inserted into other sub-codes or can be used to generate input data for other sub-codes. COPA-ABAQ is one of the nine sub-codes to calculate cracks or de-bondings in the coating layers of TRISO-coated particle fuel. Cracks and de-bondings can cause stress concentrations in the coating layers and increase the failure probability of the coated particle fuel. The COPA-ABAQ, which is in the process of being developed, is written in ABAQUS. In this study, a mechanical stress analysis was carried out by using the finite element analysis program, ABAQUS to evaluate the effect of a crack at the IPyC inner surface on the mechanical behavior of the TRISO coating layers

  8. The institutional evolution of the Brazil’s Central Bank and changes in Brazil’s monetary policy, from 1864-1998

    OpenAIRE

    Morais, Lecio Antonio Mendonça de; Câmara dos Deputados,Brasília, Distrito Federal

    2005-01-01

    This paper reviews the changes of Brazilian monetary policy between 1964 and 1998, and relates them to the shifts of the international monetary policy paradigm during this period. The study focuses especially on the 1990s. The article uses the concepts of theoretical and economic policy paradigms (Peter Hall) and organisational field (March and Olsen) to investigate the diffusion of the neoliberal monetary policy framework in Brazil. The article also considers the relationsh...

  9. A phase I study of the HSP90 inhibitor retaspimycin hydrochloride (IPI-504) in patients with gastrointestinal stromal tumors or soft-tissue sarcomas.

    Science.gov (United States)

    Wagner, Andrew J; Chugh, Rashmi; Rosen, Lee S; Morgan, Jeffrey A; George, Suzanne; Gordon, Michael; Dunbar, Joi; Normant, Emmanuel; Grayzel, David; Demetri, George D

    2013-11-01

    Heat shock protein 90 (HSP90) is required for the proper folding, function, and stability of various client proteins, two of which (KIT and PDGFRα) are critical in the pathogenesis and progression of gastrointestinal stromal tumors (GIST). This phase I study investigated the safety and maximum tolerated dose (MTD) of retaspimycin hydrochloride (IPI-504), a novel potent and selective HSP90 inhibitor, in patients with metastatic and/or unresectable GIST or other soft-tissue sarcomas (STS). IPI-504 was administered intravenously at doses ranging from 90 to 500 mg/m(2) twice weekly for 2 weeks on/1 week off. Safety, pharmacokinetic, and pharmacodynamic profiles were determined. Response was assessed by Response Evaluation Criteria for Solid Tumors (RECIST) 1.0 and optionally via 18-fluorodeoxyglucose positron emission tomography (18-FDG-PET) imaging. Fifty-four patients received IPI-504; 37 with GIST and 17 with other STS. The MTD was 400 mg/m(2) twice weekly for 2 weeks on/1 week off. Common related adverse events were fatigue (59%), headache (44%), and nausea (43%). Exposure to IPI-504, 17-AAG, and 17-AG increased with IPI-504 dose. Stable disease (SD) was observed in 70% (26 of 37) of patients with GIST and 59% (10 of 17) of patients with STS. There was one confirmed partial response (PR) in a patient with GIST and one PR in a patient with liposarcoma. Metabolic partial responses occurred in 11 of 29 (38%) patients with GIST. In this study of advanced GIST or other STS, IPI-504 was generally well-tolerated with some evidence of antitumor activity, serving as a clinical proof-of-concept that HSP90 inhibition remains a promising strategy.

  10. A phase 1 study of the heat shock protein 90 inhibitor retaspimycin hydrochloride (IPI-504) in patients with gastrointestinal stromal tumors or soft tissue sarcomas

    Science.gov (United States)

    Wagner, Andrew J.; Chugh, Rashmi; Rosen, Lee S.; Morgan, Jeffrey A.; George, Suzanne; Gordon, Michael; Dunbar, Joi; Normant, Emmanuel; Grayzel, David; Demetri, George D.

    2015-01-01

    Purpose Heat shock protein 90 (Hsp90) is required for the proper folding, function, and stability of various client proteins, two of which (KIT and PDGFRα) are critical in the pathogenesis and progression of gastrointestinal stromal tumors (GIST). This phase 1 study investigated the safety and maximum tolerated dose (MTD) of retaspimycin hydrochloride (IPI-504), a novel potent and selective Hsp90 inhibitor, in patients with metastatic and/or unresectable GIST or other soft-tissue sarcomas (STS). Experimental Design IPI-504 was administered intravenously at doses ranging from 90 to 500 mg/m2 twice weekly for 2 weeks on/1 week off. Safety, pharmacokinetic, and pharmacodynamic profiles were determined. Response was assessed by Response Evaluation Criteria for Solid Tumors (RECIST) 1.0 and optionally via 18-fluorodeoxyglucose positron emission tomography (18-FDG-PET) imaging. Results Fifty-four patients received IPI-504; 37 with GIST and 17 with other STS. The MTD was 400 mg/m2 twice weekly for 2 weeks on/1 week off. Common related adverse events were fatigue (59%), headache (44%), and nausea (43%). Exposure to IPI-504, 17-AAG, and 17-AG increased with IPI-504 dose. Stable disease (SD) was observed in 70% (26/37) of patients with GIST and 59% (10/17) of patients with STS. There was one confirmed partial response (PR) in a patient with GIST and one PR in a patient with liposarcoma. Metabolic partial responses occurred in 11/29 (38%) of GIST patients. Conclusions In this study of advanced GIST or other STS, IPI-504 was generally well-tolerated with some evidence of anti-tumor activity, serving as a clinical proof-of-concept that HSP90 inhibition remains a promising strategy. PMID:24045182

  11. The Hsp90 inhibitor IPI-504 rapidly lowers EML4-ALK levels and induces tumor regression in ALK-driven NSCLC models.

    Science.gov (United States)

    Normant, E; Paez, G; West, K A; Lim, A R; Slocum, K L; Tunkey, C; McDougall, J; Wylie, A A; Robison, K; Caliri, K; Palombella, V J; Fritz, C C

    2011-06-02

    Heat shock protein 90 (Hsp90) is an emerging target for cancer therapy due to its important role in maintaining the activity and stability of key oncogenic signaling proteins. We show here that the echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) fusion protein, presumed to be the oncogenic driver in about 5% of patients with non-small cell lung cancer (NSCLC), is associated with Hsp90 in cells and is rapidly degraded upon exposure of cells to IPI-504. We find EML4-ALK to be more sensitive to Hsp90 inhibition than either HER2 or mutant epidermal growth factor receptor (EGFR) with an inhibitory concentration (IC)(50) for protein degradation in the low nanomolar range. This degradation leads to a potent inhibition of downstream signaling pathways and to the induction of growth arrest and apoptosis in cells carrying the EML4-ALK fusion. To generate a causative link between the expression of EML4-ALK and sensitivity to IPI-504, we introduced an EML4-ALK cDNA into HEK293 cells and show that the expression of the fusion protein sensitizes cells to IPI-504 both in vitro and in vivo. In a xenograft model of a human NSCLC cell line containing the ALK rearrangement, we observe tumor regression at clinically relevant doses of IPI-504. Finally, cells that have been selected for resistance to ALK kinase inhibitors retain their sensitivity to IPI-504. We have recently observed partial responses to administration of IPI-504 as a single agent in a phase 2 clinical trial in patients with NSCLC, specifically in patients that carry an ALK rearrangement. This study provides a molecular explanation for these clinical observations.

  12. Leaving School — learning at SEA: Regular high school education alongside polar research, not only during IPY

    Science.gov (United States)

    Gatti, S.

    2006-12-01

    Against the background of unsatisfactory results from the international OECD study PISA (Program for International Student Assessment), Germany is facing a period of intense school reforms. Looking back at a tradition of school culture with too few changes during the last century, quick and radical renewal of the school system is rather unlikely. Furthermore students are increasingly turning away from natural sciences. The AWI aims at providing impulses for major changes in the schooling system and is offering solid science education not only for university students but also for a much younger audience. All efforts towards this goal are interconnected within the project SEA (Science & Education @ the AWI). Fife years ago the AWI started HIGHSEA (High school of SEA). Each year 22 high school students (grade 11) are admitted to HIGHSEA spending their last three years of school not at school but at the institute. Four subjects (biology as a major, chemistry, math and English as accessory subjects) are combined and taught fully integrated. Students leave their schools for two days each week to study, work and explore all necessary topics at the AWI. All of the curricular necessities of the four subjects are being met. After rearrangement of the temporal sequencing conceptual formulation of four major questions around AWI-topics was possible. Students are taught by teachers of the cooperating schools as well as by scientists of the AWI. Close links and intense cooperation between all three groups are the basis of fundamental changes in teaching and learning climate. For each group of students we organize a short research expedition: in August 2005 we worked in the high Arctic, in January and February 2006 we performed measurements at two eastern Atlantic seamounts. Even if the amount of data coming from these expeditions is comparatively small they still contribute to ongoing research projects of the oceanographic department. The first two groups of students finished

  13. TTI Phase 2 Institutional Support: Indian Institute of Dalit Studies ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    This funding will enhance the Indian Institute of Dalit Studies' (IIDS) role as a credible public policy institution in India by strengthening its ability to provide high-quality, influential, and policy-relevant research. About the Indian Institute of Dalit Studies IIDS is a social sciences research centre with a focus on development ...

  14. Antitumor efficacy of IPI-504, a selective heat shock protein 90 inhibitor against human epidermal growth factor receptor 2-positive human xenograft models as a single agent and in combination with trastuzumab or lapatinib.

    Science.gov (United States)

    Leow, Ching Ching; Chesebrough, Jon; Coffman, Karen T; Fazenbaker, Christine A; Gooya, John; Weng, David; Coats, Steve; Jackson, Dowdy; Jallal, Bahija; Chang, Yong

    2009-08-01

    IPI-504 is a novel, highly soluble small-molecule inhibitor of heat shock protein 90 (Hsp90), a protein chaperone essential for regulating homeostasis of oncoproteins and cell signaling proteins. Human epidermal growth factor receptor 2 (HER2; ErbB2) oncoprotein, expressed in a subset of metastatic breast cancers, is a Hsp90 client protein. In this study, we investigated the antitumor activity and the mechanism of action of IPI-504 in HER2(+), trastuzumab-sensitive and trastuzumab-refractory cell lines in vitro and in vivo. IPI-504 exhibited potent antiproliferative activities (range of IC(50), 10-40 nmol/L) against several tumor cell lines examined, whereby mechanism of action was mediated through HER2 and Akt degradation. Both intravenous and oral administration of IPI-504 assessed in multiple schedules showed potent tumor growth inhibition in vivo with corresponding degradation of HER2. The tolerability and efficacy of IPI-504 combined with either trastuzumab or lapatinib were also investigated in HER2(+) tumor xenograft models. Combination of IPI-504 with trastuzumab significantly enhanced tumor growth delay and induced greater responses when compared with either agent alone. Although, as expected, trastuzumab alone did not exhibit any significant antitumor activity in the trastuzumab-resistant JIMT-1 model, IPI-504 administered in combination with trastuzumab yielded greater antitumor efficacy than either agent alone. Finally, combination of IPI-504 and lapatinib was well tolerated up to 50 mg/kg IPI-504 and 100 mg/kg lapatinib and resulted in significant delay in tumor growth, including partial and complete tumor responses. These lines of evidence support the development of IPI-504 in HER2-positive breast cancers as a single agent and in combination with either trastuzumab or lapatinib

  15. SU-D-12A-01: An Inter-Projection Interpolation (IPI) Approach for the Synchronized Moving Grid (SMOG) to Reduce Dose in Cone Beam CT

    International Nuclear Information System (INIS)

    Zhang, H; Kong, V; Jin, J; Ren, L

    2014-01-01

    Purpose: Synchronized moving grid is a promising technique to reduce scatter and ghost artifacts in cone beam computed tomography (CBCT). However, it requires 2 projections in the same gantry angle to obtain full information due to signal blockage by the grid. We proposed an inter-projection interpolation (IPI) method to estimate blocked signals, which may reduce the scan time and the dose. This study aims to provide a framework to achieve a balance between speed, dose and image quality. Methods: The IPI method is based on the hypothesis that an abrupt signal in a projection can be well predicted by the information in the two immediate neighboring projections if the gantry angle step is small. The study was performed on a Catphan and a head phantom. The SMOG was simulated by erasing the information (filling with “0”) of the areas in each projection corresponding to the grid. An IPI algorithm was applied on each projection to recover the erased information. FDK algorithm was used to reconstruct CBCT images for the IPI-processed projections, and compared with the original image in term of signal to noise ratio (SNR) measured in the whole reconstruction image range. The effect of gantry angle step was investigated by comparing the CBCT images from projection sets of various gantry intervals, with IPI-predicted projections to fill the missing projection in the interval. Results: The IPI procession time was 1.79s±0.53s for each projection. SNR after IPI was 29.0db and 28.1db for the Catphan and head phantom, respectively, comparing to 15.3db and 22.7db for an inpainting based interpolation technique. SNR was 28.3, 28.3, 21.8, 19.3 and 17.3 db for gantry angle intervals of 1, 1.5, 2, 2.5 and 3 degrees, respectively. Conclusion: IPI is feasible to estimate the missing information, and achieve an reasonable CBCT image quality with reduced dose and scan time. This study is supported by NIH/NCI grant 1R01CA166948-01

  16. ROTC Policy Regarding Homosexuals

    Directory of Open Access Journals (Sweden)

    Lee S. Duemer

    1997-03-01

    Full Text Available This is a policy analysis, in a historical context, of how Association of American University institutions responded to Reserve Officer Training Corps policy excluding homosexuals. The time period for this study is 1982 to 1992. Qualitative methods are used to analyze data and arrive at conclusions. Secondary data provide additional depth and background. This study reveals seven different positions institutions have taken in response to ROTC policy, these include: supporting ROTC policy, neutrality, collective action, barring military recruiters from campus, distancing the institution from ROTC, and changing the campus climate. This includes examples taken from AAU institutions and rationales behind making policy decisions.

  17. Institutional obligation

    International Nuclear Information System (INIS)

    Rowan, S.S.; Berwager, S.D.

    1988-01-01

    The institutional obligation is to act to meet primary responsibilities in the face of risks. There are risks involved in taking action, both of a quantifiable and unquantifiable nature. This paper explores weighing the risks, choosing approaches that balance primary obligations with broader ones, and presenting ethical philosophies upon which policies and strategies are based. Federal government organizations and utilities--and Bonneville Power Administration qualifies as both--have a variety of responsibilities to the public they serve. The common responsibility is that of service; for Bonneville the primary responsibility is to serve the energy related needs. It is this primary institutional obligation, as it relates to other responsibilities--and the resulting strategy for handling indoor air quality in Bonneville's new homes program--that this paper examines

  18. InSAR grounding line update for Antarctica based on Post IPY data acquisition

    Science.gov (United States)

    Scheuchl, B.; Mouginot, J.; Li, X.; Milillo, P.; Rignot, E. J.

    2016-12-01

    The grounding line of a glacier is a fundamental variable needed for accurate flux measurements into the ocean, for estimating ice shelf melt rates, and for detecting fine scale glacier retreat. Satellite synthetic aperture radar (SAR) remote sensing is the state of the art for providing grounding line information through double difference interferograms. The Sentinel-1 SAR mission represents a fundamental change in the way we are monitoring ice sheets going forward. The European Space Agency and the European Union show strong support for ice sheet acquisitions and the mission has a 20-year financial commitment. Through coordination by the Polar Space Task Group (PSTG), other international SAR missions augment the Sentinel-1 acquisitions to maximize the scientific value of the data. RADARSAT-2 is currently completing its second campaign to cover Central Antarctica following 2009. TerraSAR-X and COSMO SkyMed are collecting high-resolution data in key areas. Our Antarctica-wide InSAR based grounding line product generated in 2011 is in heavy use by the scientific community. Recently we have shown the potential of Sentinel-1 for grounding line measurements and provided an update for Pope, Smith, and Kohler glaciers [1]. Expanding on this work, we provide an continent-wide update on the post IPY grounding line which is based on Sentinel-1 acquisitions in coastal Antarctica, the RADARSAT-2 campaign for Ross and Ronne/Filchner ice shelves, and COSMO SkyMed in selected areas. We compare the results with the 1996, 2000, and 2011 grounding lines, and discuss the observed changes or lack thereof by region. The largest rates of retreat are found in the Amundsen Sea Embayment at about 1km/yr (Pine Island and Thwaites Glaciers) to 2 km/yr (Smith Glacier). [1] Scheuchl, B., J. Mouginot, E. Rignot, M. Morlighem, and A. Khazendar (2016), Grounding line retreat of Pope, Smith, and Kohler Glaciers, West Antarctica, measured with Sentinel-1a radar interferometry data, Geophys. Res

  19. International antitrust institutions

    OpenAIRE

    Budzinski, Oliver

    2012-01-01

    The paper discussed the economic theory of international antitrust institutions. Economic theory shows that non-coordinated competition policies of regimes that are territorially smaller than the international markets on which business companies compete violate cross-border allocative efficiency and are deficient with respect to global welfare. At the same time, some diversity of antitrust institutions and policies promotes dynamic and evolutionary efficiency so that globally binding, worldwi...

  20. Independent Prognostic Value of Serum Markers in Diffuse Large B-Cell Lymphoma in the Era of the NCCN-IPI.

    Science.gov (United States)

    Melchardt, Thomas; Troppan, Katharina; Weiss, Lukas; Hufnagl, Clemens; Neureiter, Daniel; Tränkenschuh, Wolfgang; Schlick, Konstantin; Huemer, Florian; Deutsch, Alexander; Neumeister, Peter; Greil, Richard; Pichler, Martin; Egle, Alexander

    2015-12-01

    Several serum parameters have been evaluated for adding prognostic value to clinical scoring systems in diffuse large B-cell lymphoma (DLBCL), but none of the reports used multivariate testing of more than one parameter at a time. The goal of this study was to validate widely available serum parameters for their independent prognostic impact in the era of the National Comprehensive Cancer Network-International Prognostic Index (NCCN-IPI) score to determine which were the most useful. This retrospective bicenter analysis includes 515 unselected patients with DLBCL who were treated with rituximab and anthracycline-based chemoimmunotherapy between 2004 and January 2014. Anemia, high C-reactive protein, and high bilirubin levels had an independent prognostic value for survival in multivariate analyses in addition to the NCCN-IPI, whereas neutrophil-to-lymphocyte ratio, high gamma-glutamyl transferase levels, and platelets-to-lymphocyte ratio did not. In our cohort, we describe the most promising markers to improve the NCCN-IPI. Anemia and high C-reactive protein levels retain their power in multivariate testing even in the era of the NCCN-IPI. The negative role of high bilirubin levels may be associated as a marker of liver function. Further studies are warranted to incorporate these markers into prognostic models and define their role opposite novel molecular markers. Copyright © 2015 by the National Comprehensive Cancer Network.

  1. Activity of IPI-504, a novel heat-shock protein 90 inhibitor, in patients with molecularly defined non-small-cell lung cancer.

    Science.gov (United States)

    Sequist, Lecia V; Gettinger, Scott; Senzer, Neil N; Martins, Renato G; Jänne, Pasi A; Lilenbaum, Rogerio; Gray, Jhanelle E; Iafrate, A John; Katayama, Ryohei; Hafeez, Nafeeza; Sweeney, Jennifer; Walker, John R; Fritz, Christian; Ross, Robert W; Grayzel, David; Engelman, Jeffrey A; Borger, Darrell R; Paez, Guillermo; Natale, Ronald

    2010-11-20

    IPI-504 is a novel, water-soluble, potent inhibitor of heat-shock protein 90 (Hsp90). Its potential anticancer activity has been validated in preclinical in vitro and in vivo models. We studied the activity of IPI-504 after epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) therapy in patients with advanced, molecularly defined non-small-cell lung cancer (NSCLC). Patients with advanced NSCLC, prior treatment with EGFR TKIs, and tumor tissue available for molecular genotyping were enrolled in this prospective, nonrandomized, multicenter, phase II study of IPI-504 monotherapy. The primary outcome was objective response rate (ORR). Secondary aims included safety, progression-free survival (PFS), and analysis of activity by molecular subtypes. Seventy-six patients were enrolled between December 2007 and May 2009 from 10 United States cancer centers. An ORR of 7% (five of 76) was observed in the overall study population, 10% (four of 40) in patients who were EGFR wild-type, and 4% (one of 28) in those with EGFR mutations. Although both EGFR groups were below the target ORR of 20%, among the three patients with an ALK gene rearrangement, two had partial responses and the third had prolonged stable disease (7.2 months, 24% reduction in tumor size). The most common adverse events included grades 1 and 2 fatigue, nausea, and diarrhea. Grade 3 or higher liver function abnormalities were observed in nine patients (11.8%). IPI-504 has clinical activity in patients with NSCLC, particularly among patients with ALK rearrangements.

  2. INHERENT VICE & INSUFFICIENT PACKING CLAUSES FOR ALL RISKS INSURANCE POLICIES UNDER BRITISH INSTITUTE CARGO CLAUSES : legal issues arising from claims of loss during sea transportation of large technical equipments

    OpenAIRE

    Cheng, Jia

    2010-01-01

    Analysis and presentation of this thesis is supported by studies of many relevant cases where the major arguments are set around the exclusion clauses concerning the ‘all risks cover’ policy as found in Institute Cargo Clauses. Two cases are especially emphasized, namely Mayban General Assurance BHD v. Alstom Power Plants Ltd. and Global Process Systems Inc v. Syarikat Takaful Malaysia Berhad , mainly because of the special nature of the subject matter insured in these cases. The legal i...

  3. Greek Educational Policy: From the Collaborative Model of the School Counselor Institution of the A. Papandreou's (1981) Educational Policy towards the Model of Superintendence and Supervision of the Period 2008-2013

    Science.gov (United States)

    Evaggelia, Kalerante

    2014-01-01

    The present paper is concerned about the Greek educational policy throughout 2008-2013, which is related to teachers' evaluation and their teaching work, in comparison to the one implemented in 1981. The investigation is focused on Primary and Secondary Education in which the policy of intentions as well as legislation are concentrated on a form…

  4. International prognostic index (IPI)--a critical comparison with five multiple myeloma staging systems in the group of 270 patients treated by conventional chemotherapy.

    Science.gov (United States)

    Scudla, V; Zemanova, M; Minarik, J; Bacovsky, J; Ordeltova, M; Indrak, K; Budikova, M; Dusek, L; Farbiakova, V

    2006-01-01

    In the group of 270 patients with multiple myeloma (MM) treated during 1991-2004 by conventional chemotherapy, the prognostic value and practical utility of IPI (International Prognostic Index) was assessed and compared with five other actual staging systems. Prognostic significance was assessed using the curves of overall survival (OS) according to Kaplan-Meier and log rank test (pIPI (pIPI (median OS 77, 76 and 77 months). To select a cohort of "high risk" patients, i.e. stage 3, with very unfavourable disease prognosis, the most advantageous was the system OSS and San Miguel (median OS was 5 and 6 months) and/or SWOG system selecting patients of stage 4, i.e. "worst prognosis", with median OS 8 months. It was found that IPI did not meet expectations for effective identification of "high risk" patients (median OS of stage 3 was 20 months) nor for the distinction of different prognosis of patients during initial 25 months of MM course at stage 2 vs. 3. The study indicates that under conditions of common clinical practice and conventional chemotherapy, the staging system according to D-S is still useful, while practical application of SWOG and IPI as simpler alternative to the assessment of clinical stage should be verified by further comparative studies. In harmony with the progress in cytogenetics and molecular biology as well as a prospective requirement of individual target therapy, a future suitable stratification system should be based on parameters of internal biological properties of myeloma tissue and microenvironment of bone marrow, allowing in addition a continuous evaluation of the disease course and the effect of therapy.

  5. A pilot study of cetuximab and the hedgehog inhibitor IPI-926 in recurrent/metastatic head and neck squamous cell carcinoma.

    Science.gov (United States)

    Bowles, Daniel W; Keysar, Stephen B; Eagles, Justin R; Wang, Guoliang; Glogowska, Magdalena J; McDermott, Jessica D; Le, Phuong N; Gao, Dexiang; Ray, Charles E; Rochon, Paul J; Roop, Dennis R; Tan, Aik-Choon; Serracino, Hilary S; Jimeno, Antonio

    2016-02-01

    This phase 1, dose-finding study determined the safety, maximum tolerated dose (MTD)/recommended phase 2 dose (RP2D), antitumor activity, and molecular correlates of IPI-926, a Hedgehog pathway (HhP) inhibitor, combined with cetuximab in patients with relapsed/metastatic squamous cell carcinoma of the head and neck. Cetuximab was given with a 400mg/m(2) loading dose followed by 250mg/m(2) weekly. IPI-926 was given daily starting two weeks after cetuximab initiation. A "3+3" study design was used. Prior therapy with cetuximab was allowed. Tumor biopsies occurred prior to cetuximab initiation, prior to IPI-926 initiation, and after treatment with both drugs. Nine patients were enrolled. The RP2D was 160mg, the same as the single-agent IPI-926 MTD. Among 9 treated, 8 evaluable patients, the best responses were 1 partial response (12.5%), 4 stable disease (50%), and 3 disease progressions (37.5%). The median progression free survival was 77days (95% confidence interval 39-156). Decreases in tumor size were seen in both cetuximab-naïve patients (one HPV-positive, one HPV-negative). The most frequent treatment-emergent adverse events were fatigue, muscle cramps, and rash. No DLTs were observed. Tumor shrinkage and progression free survival were associated with intra-tumoral ErbB and HhP gene expression down-regulation during therapy, supporting the preclinical hypothesis. Treatment with IPI-926 and cetuximab yielded expected toxicities with signs of anti-tumor activity. Serial tumor biopsies were feasible and revealed proof-of-concept biomarkers. Copyright © 2015 Elsevier Ltd. All rights reserved.

  6. Environmental policy performance revisited

    DEFF Research Database (Denmark)

    Daugbjerg, Carsten; Sønderskov, Kim Mannemar

    2012-01-01

    Studies of environmental policy performance tend to concentrate on the impact of particular policy institutions or of single policy instruments. However, environmental policies most often consist of a package of policy instruments. Further, these studies pay no or very little attention to policy......-country variation in organic food consumption is explained by differences in the packages of policy instruments applied, controlling for numerous systemic and individual-level alternative explanations. The analysis suggests that for environmental and political reasons, governments should apply more demand......-side instruments when introducing environmental policies....

  7. Self-renewal of acute lymphocytic leukemia cells is limited by the Hedgehog pathway inhibitors cyclopamine and IPI-926.

    Science.gov (United States)

    Lin, Tara L; Wang, Qiuju H; Brown, Patrick; Peacock, Craig; Merchant, Akil A; Brennan, Sarah; Jones, Evan; McGovern, Karen; Watkins, D Neil; Sakamoto, Kathleen M; Matsui, William

    2010-12-28

    Conserved embryonic signaling pathways such as Hedgehog (Hh), Wingless and Notch have been implicated in the pathogenesis of several malignancies. Recent data suggests that Hh signaling plays a role in normal B-cell development, and we hypothesized that Hh signaling may be important in precursor B-cell acute lymphocytic leukemia (B-ALL). We found that the expression of Hh pathway components was common in human B-ALL cell lines and clinical samples. Moreover, pathway activity could be modulated by Hh ligand or several pathway inhibitors including cyclopamine and the novel SMOOTHENED (SMO) inhibitor IPI-926. The inhibition of pathway activity primarily impacted highly clonogenic B-ALL cells expressing aldehyde dehydrogenase (ALDH) by limiting their self-renewal potential both in vitro and in vivo. These data demonstrate that Hh pathway activation is common in B-ALL and represents a novel therapeutic target regulating self-renewal and persistence of the malignant clone.

  8. Self-renewal of acute lymphocytic leukemia cells is limited by the Hedgehog pathway inhibitors cyclopamine and IPI-926.

    Directory of Open Access Journals (Sweden)

    Tara L Lin

    Full Text Available Conserved embryonic signaling pathways such as Hedgehog (Hh, Wingless and Notch have been implicated in the pathogenesis of several malignancies. Recent data suggests that Hh signaling plays a role in normal B-cell development, and we hypothesized that Hh signaling may be important in precursor B-cell acute lymphocytic leukemia (B-ALL. We found that the expression of Hh pathway components was common in human B-ALL cell lines and clinical samples. Moreover, pathway activity could be modulated by Hh ligand or several pathway inhibitors including cyclopamine and the novel SMOOTHENED (SMO inhibitor IPI-926. The inhibition of pathway activity primarily impacted highly clonogenic B-ALL cells expressing aldehyde dehydrogenase (ALDH by limiting their self-renewal potential both in vitro and in vivo. These data demonstrate that Hh pathway activation is common in B-ALL and represents a novel therapeutic target regulating self-renewal and persistence of the malignant clone.

  9. Barriers to Career Flexibility in Academic Medicine: A Qualitative Analysis of Reasons for the Underutilization of Family-Friendly Policies, and Implications for Institutional Change and Department Chair Leadership.

    Science.gov (United States)

    Shauman, Kimberlee; Howell, Lydia P; Paterniti, Debora A; Beckett, Laurel A; Villablanca, Amparo C

    2018-02-01

    Academic medical and biomedical professionals need workplace flexibility to manage the demands of work and family roles and meet their commitments to both, but often fail to use the very programs and benefits that provide flexibility. This study investigated the reasons for faculty underutilization of work-life programs. As part of a National Institutes of Health-funded study, in 2010 the authors investigated attitudes of clinical and/or research biomedical faculty at the University of California, Davis, toward work-life policies, and the rationale behind their individual decisions regarding use of flexibility policies. The analysis used verbatim responses from 213 of 472 faculty (448 unstructured comments) to a series of open-ended survey questions. Questions elicited faculty members' self-reports of policy use, attitudes, and evaluations of the policies, and their perceptions of barriers that limited full benefit utilization. Data were coded and analyzed using a grounded theory approach. Faculty described how their utilization of workplace flexibility benefits was inhibited by organizational influences: the absence of reliable information about program eligibility and benefits, workplace norms and cultures that stigmatized program participation, influence of uninformed/unsupportive department heads, and concerns about how participation might burden coworkers, damage collegial relationships, or adversely affect workflow and grant funding. Understanding underuse of work-life programs is essential to maximize employee productivity and satisfaction, minimize turnover, and provide equal opportunities for career advancement to all faculty. The findings are discussed in relation to specific policy recommendations, implications for institutional change, and department chair leadership.

  10. Report on a survey in fiscal 1999. The survey on structuring institutions for energy environment policies. Part 2. Collection of information about policies in major countries for prevention of global warming; 1999 nendo energy kankyo seisaku no seido kochiku ni kansuru chosa. 2. Kakkoku ondanka boshi seisaku johoshu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    The present survey is intended to collect and put in order the literatures and items of information related to: the current status and future directionality in the policies in advanced nations related to achieving the targets of the Kyoto Protocol, and trends of improving national institutions to respond to the Kyoto mechanisms, and the background of the conceptions thereof (including the conceptions on designing the international institutions). The survey gives considerations at the same time on possibilities of realization of the policies being implement and/or discussed. The report consists of two parts. Part 1 puts in order the trends until the most recent date in the summary of warming prevention policies in the major European and North American countries, placing the importance on the policies and measures that use economic methods (environment taxation system, national discharge quantity transaction, voluntary action plans and agreements). Part 2 (the present paper) introduces the contents of the major literatures and administrative materials in the policy trends in each nation, and puts in order the basic items of information that are considered useful for performing in the future the surveys related to the subject areas. (NEDO)

  11. HIPÓTESES DE MERCADO EFICIENTE: UM ESTUDO DE EVENTOS A PARTIR DA REDUÇÃO DO IPI

    Directory of Open Access Journals (Sweden)

    Fernanda Sousa Gabriel

    2013-04-01

    Full Text Available A Hipótese de Eficiência do Mercado (HME desenvolvida por Fama (1970, 1991 afirma em sua forma semiforte que os preços ajustam-se instantaneamente a qualquer informação relevante divulgada publicamente, restringindo as oportunidades de obtenção de retornos anormais de maneira contínua. O objetivo deste estudo é verificar qual o comportamento dos preços de ações de companhias que pertencem aos segmentos da linha branca (eletrodomésticos, móveis, papel e celulose, nos dias próximos ao comunicado do governo sobre a redução do Imposto sobre Produtos Industrializados (IPI, ocorrido no dia 26 de março de 2012, visando identificar se o mercado de capitais apresentou a eficiência informacional na forma semiforte. Utilizou-se a metodologia de estudo de evento, a qual avalia retornos anormais dos ativos em relação ao mercado. A coleta de dados deu-se por meio das séries históricas disponibilizadas no site da BM&FBovespa (Bolsa de Valores, Mercadorias e Futuros. A análise do retorno anormal na janela de evento (5 dias antes e após o anúncio sobre a redução do IPI mostrou retornos anormais significativos nos dias t-1 e t-2 a t+3. Os resultados mostraram que o mercado de capitais brasileiro não apresentou comportamento condizente com a HME, especificamente na forma de eficiência semiforte.

  12. A study of Traveling Ionospheric Disturbances and Atmospheric Gravity Waves using EISCAT Svalbard Radar IPY-data

    Directory of Open Access Journals (Sweden)

    A. Vlasov

    2011-11-01

    Full Text Available We present a statistical study of Traveling Ionospheric Disturbances (TIDs as observed by the EISCAT Svalbard Radar (ESR during the continuous IPY-run (March 2007–February 2008 with field-aligned measurements. We have developed a semi-automatic routine for searching and extracting Atmospheric Gravity Wave (AGW activity. The collected data shows that AGW-TID signatures are common in the high-latitude ionosphere especially in the field-aligned ion velocity data (244 cases of AGW-TID signatures in daily records, but they can be observed also in electron density (26 cases, electron temperature (12 cases and ion temperature (26 cases. During the IPY campaign (in solar minimum conditions AGW-TID events appear more frequently during summer months than during the winter months. It remains still as a topic for future studies whether the observed seasonal variation is natural or caused by seasonal variation in the performance of the observational method that we use (AGW-TID signature may be more pronounced in a dense ionosphere. In our AGW-TID dataset the distribution of the oscillation periods has two peaks, one around 0.5–0.7 h and the other around 1.1–1.3 h. The diurnal occurrence rate has a deep minimum in the region of magnetic midnight, which might be partly explained by irregular auroral activity obscuring the TID signatures from our detection routines. As both the period and horizontal phase speed estimates (as derived from the classical AGW dispersion relation show values typical both for large scale TIDs and mesoscale TIDs it is difficult to distinguish whether the generator for high-latitude AGW-TIDs resides typically in the troposphere or in the near-Earth space. The results of our statistical analysis give anyway some valuable reference information for the future efforts to learn more about the dominating TID source mechanisms in polar cap conditions, and to improve AGW simulations.

  13. HIPÓTESES DE MERCADO EFICIENTE: UM ESTUDO DE EVENTOS A PARTIR DA REDUÇÃO DO IPI

    Directory of Open Access Journals (Sweden)

    Kárem Cristina de Sousa Ribeiro

    2013-04-01

    Full Text Available A Hipótese de Eficiência do Mercado (HME desenvolvida por Fama (1970, 1991 afirma em sua forma semiforte que os preços ajustam-se instantaneamente a qualquer informação relevante divulgada publicamente, restringindo as oportunidades de obtenção de retornos anormais de maneira contínua. O objetivo deste estudo é verificar qual o comportamento dos preços de ações de companhias que pertencem aos segmentos da linha branca (eletrodomésticos, móveis, papel e celulose, nos dias próximos ao comunicado do governo sobre a redução do Imposto sobre Produtos Industrializados (IPI, ocorrido no dia 26 de março de 2012, visando identificar se o mercado de capitais apresentou a eficiência informacional na forma semiforte. Utilizou-se a metodologia de estudo de evento, a qual avalia retornos anormais dos ativos em relação ao mercado. A coleta de dados deu-se por meio das séries históricas disponibilizadas no site da BM&FBovespa (Bolsa de Valores, Mercadorias e Futuros. A análise do retorno anormal na janela de evento (5 dias antes e após o anúncio sobre a redução do IPI mostrou retornos anormais significativos nos dias t-1 e t-2 a t+3. Os resultados mostraram que o mercado de capitais brasileiro não apresentou comportamento condizente com a HME, especificamente na forma de eficiência semiforte

  14. TTI Phase 2 Institutional Support: African Heritage Institution | CRDI ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    This funding will help strengthen the African Heritage Institution's (AfriHeritage) role as a credible public policy institution in Nigeria by enhancing its ability to provide high-quality, influential, and policy-relevant research. About AfriHeritage AfriHeritage is a non-profit, non-partisan organization, incorporated in Nigeria in 2000 ...

  15. Furthering critical institutionalism

    Directory of Open Access Journals (Sweden)

    Frances Dalton Cleaver

    2015-03-01

    Full Text Available This special issue furthers the study of natural resource management from a critical institutional perspective. Critical institutionalism (CI is a contemporary body of thought that explores how institutions dynamically mediate relationships between people, natural resources and society. It focuses on the complexity of institutions entwined in everyday social life, their historical formation, the interplay between formal and informal, traditional and modern arrangements, and the power relations that animate them. In such perspectives a social justice lens is often used to scrutinise the outcomes of institutional processes. We argue here that critical institutional approaches have potentially much to offer commons scholarship, particularly through the explanatory power of the concept of bricolage for better understanding institutional change.  Critical institutional approaches, gathering momentum over the past 15 years or so, have excited considerable interest but the insights generated from different disciplinary perspectives remain insufficiently synthesised. Analyses emphasising complexity can be relatively illegible to policy-makers, a fact which lessens their reach. This special issue therefore aims to synthesise critical institutional ideas and so to lay the foundation for moving beyond the emergent stage to make meaningful academic and policy impact. In bringing together papers here we define and synthesise key themes of critical institutionalism, outline the concept of institutional bricolage and identity some key challenges facing this school of thought.

  16. TTI Phase 2 Institutional Support: Makerere Institute of Social ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    MISR) role as a credible public policy institution in Uganda by enhancing its ability to provide high-quality, influential, and policy-relevant research. About the ... Nutrition, health policy, and ethics in the age of public-private partnerships. How are ...

  17. Investigacion Educativa: Areas - Politicas - Estrategias y Proyectos del ICOLPE, 2 (Educational Research: Topics, Policies, Strategies, and Projects of the Colombian Institute of Pedagogy, 2),

    Science.gov (United States)

    Ministerio de Educacion Nacional, Bogota (Colombia). Instituto Colombiano de Pedagogia.

    This booklet defines and establishes guidelines for educational research in Colombia. Sections describe basic philosophy and objectives, types of research, policies for educational investigation, governmental role, and principle areas for educational research. A listing of current and proposed research projects is provided. The final section…

  18. 2013 Asia-Pacific Education Research Institutes Network (ERI-Net) Regional Study on Transversal Competencies in Education Policy & Practice (Phase I). Regional Synthesis Report

    Science.gov (United States)

    Yoko, Satoko

    2015-01-01

    This report provides an understanding of how transversal competencies are viewed, implemented, and adapted in education policy and curriculum across the Asia-Pacific region. The publication consolidates the results of ten country studies carried out in 2013-2014 in ten countries and economies of the Asia-Pacific region, including: Australia; China…

  19. Implementing an institution-wide quality improvement policy to ensure appropriate use of continuous cardiac monitoring: a mixed-methods retrospective data analysis and direct observation study.

    Science.gov (United States)

    Rayo, Michael F; Mansfield, Jerry; Eiferman, Daniel; Mignery, Traci; White, Susan; Moffatt-Bruce, Susan D

    2016-10-01

    Hospitals have been slow to adopt guidelines from the American Heart Association (AHA) limiting the use of continuous cardiac monitoring for fear of missing important patient cardiac events. A new continuous cardiac monitoring policy was implemented at a tertiary-care hospital seeking to monitor only those patients who were clinically indicated and decrease the number of false alarms in order to improve overall alarm response. Leadership support was secured, a cross-functional alarm management task force was created, and a system-wide policy was developed based on current AHA guidelines. Process measures, including cardiac monitoring rate, monitored transport rate, emergency department (ED) boarding rate and the percentage of false, unnecessary and true alarms, were measured to determine the policy's impact on patient care. Outcome measures, including length of stay and mortality rate, were measured to determine the impact on patient outcomes. Cardiac monitoring rate decreased 53.2% (0.535 to 0.251 per patient day, pimprovements in process measures coupled with no adverse effects to patient outcomes suggest that the overall system became more resilient to current and emerging demands. This study indicates that when collaboration across a diverse team is coupled with strong leadership support, policies and procedures such as this one can improve clinical practice and patient care. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  20. Historical overview of development policies and institutions in the Netherlands, in the context of private sector development and (productive) employment creation

    NARCIS (Netherlands)

    Kazimierczuk, A.H.

    2015-01-01

    This paper reviews the Dutch development cooperation policies for the years 1949-2015 with particular attention for private sector development (PSD). Over the years, poverty alleviation, private sector development and security have been dominant focus areas of Dutch development cooperation, with PSD