Two-way communication between SecY and SecA suggests a Brownian ratchet mechanism for protein translocation.

Science.gov (United States)

Allen, William John; Corey, Robin Adam; Oatley, Peter; Sessions, Richard Barry; Baldwin, Steve A; Radford, Sheena E; Tuma, Roman; Collinson, Ian

2016-05-16

The essential process of protein secretion is achieved by the ubiquitous Sec machinery. In prokaryotes, the drive for translocation comes from ATP hydrolysis by the cytosolic motor-protein SecA, in concert with the proton motive force (PMF). However, the mechanism through which ATP hydrolysis by SecA is coupled to directional movement through SecYEG is unclear. Here, we combine all-atom molecular dynamics (MD) simulations with single molecule FRET and biochemical assays. We show that ATP binding by SecA causes opening of the SecY-channel at long range, while substrates at the SecY-channel entrance feed back to regulate nucleotide exchange by SecA. This two-way communication suggests a new, unifying 'Brownian ratchet' mechanism, whereby ATP binding and hydrolysis bias the direction of polypeptide diffusion. The model represents a solution to the problem of transporting inherently variable substrates such as polypeptides, and may underlie mechanisms of other motors that translocate proteins and nucleic acids.

Kinetic Resolution of sec-Thiols by Enantioselective Oxidation with Rationally Engineered 5-(Hydroxymethyl)furfural Oxidase.

Science.gov (United States)

Pickl, Mathias; Swoboda, Alexander; Romero, Elvira; Winkler, Christoph K; Binda, Claudia; Mattevi, Andrea; Faber, Kurt; Fraaije, Marco W

2018-03-05

Various flavoprotein oxidases were recently shown to oxidize primary thiols. Herein, this reactivity is extended to sec-thiols by using structure-guided engineering of 5-(hydroxymethyl)furfural oxidase (HMFO). The variants obtained were employed for the oxidative kinetic resolution of racemic sec-thiols, thus yielding the corresponding thioketones and nonreacted R-configured thiols with excellent enantioselectivities (E≥200). The engineering strategy applied went beyond the classic approach of replacing bulky amino acid residues with smaller ones, as the active site was additionally enlarged by a newly introduced Thr residue. This residue established a hydrogen-bonding interaction with the substrates, as verified in the crystal structure of the variant. These strategies unlocked HMFO variants for the enantioselective oxidation of a range of sec-thiols. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Guide to Policies and Contracts on Job Sharing in the Schools.

Science.gov (United States)

Moorman, Barbara; And Others

Job Sharing--two persons sharing one full-time position--is becoming increasingly popular in the nation's schools. This guide provides information on policies and contracts and collective bargaining implications, based on practices in California, where the job sharing is allowed in 27 percent of the school districts. Provisions of policies and…

Midmarket Solar Policies in the United States: A Guide for Midsized Solar Customers

Energy Technology Data Exchange (ETDEWEB)

Tian, Tian [National Renewable Energy Lab. (NREL), Golden, CO (United States); Liu, Chang [National Renewable Energy Lab. (NREL), Golden, CO (United States); O' Shaughnessy, Eric [National Renewable Energy Lab. (NREL), Golden, CO (United States); Mathur, Shivani [National Renewable Energy Lab. (NREL), Golden, CO (United States); Holm, Alison [National Renewable Energy Lab. (NREL), Golden, CO (United States); Miller, John [National Renewable Energy Lab. (NREL), Golden, CO (United States)

2016-09-01

The midscale market for solar photovoltaics (PV) has not experienced the same high growth rate as residential- or utility-scale market segments in the past five years when solar PV deployment increased rapidly. Midscale solar can be defined as behind-the-meter solar PV between 50 kilowatts and 2 megawatts adopted by multi-housing residential, commercial, industrial, non-profit, and other entities. A number of challenges face the midscale segment, including difficulties in contracting, mismatch between tenant lease and PV financing terms, high transaction costs relative to project sizes, and inefficiencies in matching prospective projects with capital. The changing policy landscape across U.S. states provides both opportunities and challenges to midmarket solar. Some states, such as California, are expanding system capacity limits for policies such as net metering, thus enabling a wider range of customers to benefit from excess generation. A number of states and utilities are making changes to rate design to introduce new or higher user fees for solar customers or reduced tariffs for net metering, which decrease the value of solar generation. An understanding of these policies relative to project feasibility and economics is important for prospective customers to make informed decisions to adopt solar PV. This guide complements existing solar policy resources to help potential customers navigate through the policy landscape in order to make informed decisions for their solar investment. The first part of this guide introduces the key solar policies necessary for policy-based decision-making, which involves using knowledge of a solar policy to improve project economics and efficiency. Policies that could result in policy-based decisions include interconnection standards, net metering, user fees, incentives, and third-party ownership policies. The goal of this section is to equip prospective customers and project developers with the tools necessary to understand and

Epithelial organization and cyst lumen expansion require efficient Sec13-Sec31-driven secretion.

Science.gov (United States)

Townley, Anna K; Schmidt, Katy; Hodgson, Lorna; Stephens, David J

2012-02-01

Epithelial morphogenesis is directed by interactions with the underlying extracellular matrix. Secretion of collagen and other matrix components requires efficient coat complex II (COPII) vesicle formation at the endoplasmic reticulum. Here, we show that suppression of the outer layer COPII component, Sec13, in zebrafish embryos results in a disorganized gut epithelium. In human intestinal epithelial cells (Caco-2), Sec13 depletion causes defective epithelial polarity and organization on permeable supports. Defects are seen in the ability of cells to adhere to the substrate, form a monolayer and form intercellular junctions. When embedded in a three-dimensional matrix, Sec13-depleted Caco-2 cells form cysts but, unlike controls, are defective in lumen expansion. Incorporation of primary fibroblasts within the three-dimensional culture substantially restores normal morphogenesis. We conclude that efficient COPII-dependent secretion, notably assembly of Sec13-Sec31, is required to drive epithelial morphogenesis in both two- and three-dimensional cultures in vitro, as well as in vivo. Our results provide insight into the role of COPII in epithelial morphogenesis and have implications for the interpretation of epithelial polarity and organization assays in cell culture.

Chaperone-Mediated Sec61 Channel Gating during ER Import of Small Precursor Proteins Overcomes Sec61 Inhibitor-Reinforced Energy Barrier

Directory of Open Access Journals (Sweden)

Sarah Haßdenteufel

2018-05-01

Full Text Available Summary: Protein transport into the mammalian endoplasmic reticulum (ER is mediated by the heterotrimeric Sec61 channel. The signal recognition particle (SRP and TRC systems and Sec62 have all been characterized as membrane-targeting components for small presecretory proteins, whereas Sec63 and the lumenal chaperone BiP act as auxiliary translocation components. Here, we report the transport requirements of two natural, small presecretory proteins and engineered variants using semipermeabilized human cells after the depletion of specific ER components. Our results suggest that hSnd2, Sec62, and SRP and TRC receptor each provide alternative targeting pathways for short secretory proteins and define rules of engagement for the actions of Sec63 and BiP during their membrane translocation. We find that the Sec62/Sec63 complex plus BiP can facilitate Sec61 channel opening, thereby allowing precursors that have weak signal peptides or other inhibitory features to translocate. A Sec61 inhibitor can mimic the effect of BiP depletion on Sec61 gating, suggesting that they both act at the same essential membrane translocation step. : Protein transport into the human endoplasmic reticulum (ER is mediated by the heterotrimeric Sec61 channel. Haßdenteufel et al. map the determinants for requirement of different targeting pathways and different auxiliary components of the Sec61 channel in ER import of short presecretory proteins. Different characteristics of precursor polypeptides dictate the engagement of each component. Keywords: endoplasmic reticulum, protein targeting and translocation, Sec61 channel gating, Sec62, Sec63, BiP, CAM741, signal peptide, mature region, cluster of positive charges

Anti-Americanism and U.S. Foreign Policy

Science.gov (United States)

2003-04-07

interesting paradox – American culture is both loved and feared – and it is not uncommon to hear stories of popular international McDonald’s franchises also...Mark McDonald , “Egyptians Growing More Resentful of U.S. Foreign Policy,” Philadelphia Inquirer, 16 December 2002, sec. A, p. 1. 24 Michael J. Jordan...2002, sec. A, p. 1. McDonald , Mark. “Egyptians Growing More Resentful of U.S. Foreign Policy.” Philadelphia Inquirer, 16 December 2002, sec. A, p. 1

Epithelial organization and cyst lumen expansion require efficient Sec13–Sec31-driven secretion

Science.gov (United States)

Townley, Anna K.; Schmidt, Katy; Hodgson, Lorna; Stephens, David J.

2012-01-01

Epithelial morphogenesis is directed by interactions with the underlying extracellular matrix. Secretion of collagen and other matrix components requires efficient coat complex II (COPII) vesicle formation at the endoplasmic reticulum. Here, we show that suppression of the outer layer COPII component, Sec13, in zebrafish embryos results in a disorganized gut epithelium. In human intestinal epithelial cells (Caco-2), Sec13 depletion causes defective epithelial polarity and organization on permeable supports. Defects are seen in the ability of cells to adhere to the substrate, form a monolayer and form intercellular junctions. When embedded in a three-dimensional matrix, Sec13-depleted Caco-2 cells form cysts but, unlike controls, are defective in lumen expansion. Incorporation of primary fibroblasts within the three-dimensional culture substantially restores normal morphogenesis. We conclude that efficient COPII-dependent secretion, notably assembly of Sec13–Sec31, is required to drive epithelial morphogenesis in both two- and three-dimensional cultures in vitro, as well as in vivo. Our results provide insight into the role of COPII in epithelial morphogenesis and have implications for the interpretation of epithelial polarity and organization assays in cell culture. PMID:22331354

Teacher Pay and Career Paths in an Opportunity Culture: A Practical Policy Guide

Science.gov (United States)

Hassel, Emily Ayscue; Holly, Christen; Locke, Gillian

2014-01-01

To help all students reach their potential, district leaders must ensure that every student has consistent access to excellent teaching. Opportunity Culture compensation and career path structures help make that possible, and this guide shows how. "Teacher Pay and Career Paths in an Opportunity Culture: A Practical Policy Guide" shows…

Fit, Healthy, and Ready To Learn: A School Health Policy Guide. Part II: Policies To Promote Sun Safety and Prevent Skin Cancer.

Science.gov (United States)

Fraser, Katherine

This publication is a supplementary chapter to "Fit, Healthy, and Ready to Learn: A School Health Policy Guide; Part I: General School Health Policies, Physical Activity, Healthy Eating, and Tobacco-Use Prevention." It discusses various aspects of a complete school policy and plan to promote sun safety. The first section "Purpose…

46 CFR Sec. 13 - Insurance.

Science.gov (United States)

2010-10-01

... REPAIRS UNDER NATIONAL SHIPPING AUTHORITY MASTER LUMP SUM REPAIR CONTRACT-NSA-LUMPSUMREP Sec. 13 Insurance. Article 9 of the NSA-LUMPSUMREP Contract sets forth the Contractor's liabilities and obligations with... 46 Shipping 8 2010-10-01 2010-10-01 false Insurance. Sec. 13 Section 13 Shipping MARITIME...

46 CFR Sec. 15 - Subcontracts.

Science.gov (United States)

2010-10-01

... REPAIRS UNDER NATIONAL SHIPPING AUTHORITY MASTER LUMP SUM REPAIR CONTRACT-NSA-LUMPSUMREP Sec. 15 Subcontracts. Under Article 29 of the NSA-LUMPSUMREP Contract, the Contractor is authorized to subcontract... 46 Shipping 8 2010-10-01 2010-10-01 false Subcontracts. Sec. 15 Section 15 Shipping MARITIME...

46 CFR Sec. 5 - Accounting.

Science.gov (United States)

2010-10-01

... 46 Shipping 8 2010-10-01 2010-10-01 false Accounting. Sec. 5 Section 5 Shipping MARITIME... Sec. 5 Accounting. The General Agent shall record the amounts of compensation paid from the NSA... Accounting Office, at which time the Maritime Administration will take custody of the records. [16 FR 2885...

46 CFR Sec. 12 - Audit.

Science.gov (United States)

2010-10-01

... 46 Shipping 8 2010-10-01 2010-10-01 false Audit. Sec. 12 Section 12 Shipping MARITIME... TRANSACTIONS UNDER AGENCY AGREEMENTS Reports and Audit Sec. 12 Audit. (a) The owner will audit as currently as possible subsequent to audit by the agent, all documents relating to the activities, maintenance and...

Shear-wave elastography for breast masses: local shear wave speed (m/sec) versus Young modulus (kPa).

Science.gov (United States)

Youk, Ji Hyun; Son, Eun Ju; Park, Ah Young; Kim, Jeong-Ah

2014-01-01

To evaluate and compare the performance of shear-wave elastography (SWE) for breast masses using the local shear wave speed (m/sec) vs. Young modulus (kPa). A total of 130 breast lesions in 123 women who underwent SWE before ultrasound- guided core needle biopsy or surgical excision were included. With the region-of-interest placed over the stiffest areas of the lesion on SWE, the quantitative mean, maximum, and standard deviation (SD) of the elasticity values were measured in kPa and m/sec for each lesion. The SD was also measured with the region-of-interest including the whole breast lesion (wSD). The area under the receiver operating characteristic curve (AUC), sensitivity, and specificity of each elasticity value measured in kPa and m/sec were compared. Of the 130 lesions, 49 (37.7%) were malignant and 81 (62.3%) were benign. The AUCs for the mean, maximum, and SD of the elasticity values using kPa and m/sec did not differ significantly: mean, 0.974 vs. 0.974; maximum, 0.960 vs. 0.976; SD, 0.916 vs. 0.916. However, the AUC for wSD showed a significant difference: 0.964 (kPa) vs. 0.960 (m/sec) (P=0.036). There was no significant difference in the sensitivity and specificity of the mean, maximum, and wSD of the elasticity values. However, the specificity of the SD was significantly different between the two different measurements: 95.1% (kPa) vs. 87.7% (m/sec) (P=0.031). The quantitative elasticity values measured in kPa and m/sec on SWE showed good diagnostic performance. The specificity of the SD and AUC of the wSD measured in kPa were significantly higher than those measured in m/sec.

Shear-wave elastography for breast masses: local shear wave speed (m/sec) versus Young modulus (kPa)

Energy Technology Data Exchange (ETDEWEB)

Youk, Ji Hyun; Son, Eun Ju; Park, Ah Young; Kim, Jeong Ah [Dept. of Radiology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul (Korea, Republic of)

2014-03-15

To evaluate and compare the performance of shear-wave elastography (SWE) for breast masses using the local shear wave speed (m/sec) vs. Young modulus (kPa). A total of 130 breast lesions in 123 women who underwent SWE before ultrasound- guided core needle biopsy or surgical excision were included. With the region-of-interest placed over the stiffest areas of the lesion on SWE, the quantitative mean, maximum, and standard deviation (SD) of the elasticity values were measured in kPa and m/sec for each lesion. The SD was also measured with the region-of-interest including the whole breast lesion (wSD). The area under the receiver operating characteristic curve (AUC), sensitivity, and specificity of each elasticity value measured in kPa and m/sec were compared. Of the 130 lesions, 49 (37.7%) were malignant and 81 (62.3%) were benign. The AUCs for the mean, maximum, and SD of the elasticity values using kPa and m/sec did not differ significantly: mean, 0.974 vs. 0.974; maximum, 0.960 vs. 0.976; SD, 0.916 vs. 0.916. However, the AUC for wSD showed a significant difference: 0.964 (kPa) vs. 0.960 (m/sec) (P=0.036). There was no significant difference in the sensitivity and specificity of the mean, maximum, and wSD of the elasticity values. However, the specificity of the SD was significantly different between the two different measurements: 95.1% (kPa) vs. 87.7% (m/sec) (P=0.031). The quantitative elasticity values measured in kPa and m/sec on SWE showed good diagnostic performance. The specificity of the SD and AUC of the wSD measured in kPa were significantly higher than those measured in m/sec.

Shear-wave elastography for breast masses: local shear wave speed (m/sec) versus Young modulus (kPa)

International Nuclear Information System (INIS)

Youk, Ji Hyun; Son, Eun Ju; Park, Ah Young; Kim, Jeong Ah

2014-01-01

To evaluate and compare the performance of shear-wave elastography (SWE) for breast masses using the local shear wave speed (m/sec) vs. Young modulus (kPa). A total of 130 breast lesions in 123 women who underwent SWE before ultrasound- guided core needle biopsy or surgical excision were included. With the region-of-interest placed over the stiffest areas of the lesion on SWE, the quantitative mean, maximum, and standard deviation (SD) of the elasticity values were measured in kPa and m/sec for each lesion. The SD was also measured with the region-of-interest including the whole breast lesion (wSD). The area under the receiver operating characteristic curve (AUC), sensitivity, and specificity of each elasticity value measured in kPa and m/sec were compared. Of the 130 lesions, 49 (37.7%) were malignant and 81 (62.3%) were benign. The AUCs for the mean, maximum, and SD of the elasticity values using kPa and m/sec did not differ significantly: mean, 0.974 vs. 0.974; maximum, 0.960 vs. 0.976; SD, 0.916 vs. 0.916. However, the AUC for wSD showed a significant difference: 0.964 (kPa) vs. 0.960 (m/sec) (P=0.036). There was no significant difference in the sensitivity and specificity of the mean, maximum, and wSD of the elasticity values. However, the specificity of the SD was significantly different between the two different measurements: 95.1% (kPa) vs. 87.7% (m/sec) (P=0.031). The quantitative elasticity values measured in kPa and m/sec on SWE showed good diagnostic performance. The specificity of the SD and AUC of the wSD measured in kPa were significantly higher than those measured in m/sec.

Teacher Pay and Career Paths in an Opportunity Culture: A Practical Policy Guide--Summary

Science.gov (United States)

Hassel, Emily Ayscue; Holly, Christen; Locke, Gillian

2014-01-01

To help all students reach their potential, district leaders must ensure that every student has consistent access to excellent teaching. Opportunity Culture compensation and career path structures help make that possible, and this guide shows how. "Teacher Pay and Career Paths in an Opportunity Culture: A Practical Policy Guide" shows…

Employer Child Care Resources: A Guide to Developing Effective Child Care Programs and Policies.

Science.gov (United States)

Women's Bureau (DOL), Washington, DC.

Increasing numbers of employers are responding to employee child care needs by revising their benefit packages, work schedules, and recruitment plans to include child care options. This guide details ways to develop effective child care programs and policies. Section 1 of the guide describes employees' growing child care needs and employers'…

46 CFR Sec. 18 - Group classification.

Science.gov (United States)

2010-10-01

... 46 Shipping 8 2010-10-01 2010-10-01 false Group classification. Sec. 18 Section 18 Shipping... Sec. 18 Group classification. In the preparation of specifications, Job Orders, Supplemental Job... inserted thereon: Number Classification 41 Maintenance Repairs (deck, engine and stewards department...

Policymaker's Guide to Feed-in Tariff Policy Design

Energy Technology Data Exchange (ETDEWEB)

Couture, T. D.; Cory, K.; Kreycik, C.; Williams, E.

2010-07-01

Feed-in tariffs (FITs) are the most widely used renewable energy policy in the world for driving accelerating renewable energy (RE) deployment, accounting for a greater share of RE development than either tax incentives or renewable portfolio standard (RPS) policies. FITs have generated significant RE deployment, helping bring the countries that have implemented them successfully to the forefront of the global RE industry. In the European Union (EU), FIT policies have led to the deployment of more than 15,000 MW of solar photovoltaic (PV) power and more than 55,000 MW of wind power between 2000 and the end of 2009. In total, FITs are responsible for approximately 75% of global PV and 45% of global wind deployment. Countries such as Germany, in particular, have demonstrated that FITs can be used as a powerful policy tool to drive RE deployment and help meet combined energy security and emissions reductions objectives. This policymaker's guide provides a detailed analysis of FIT policy design and implementation and identifies a set of best practices that have been effective at quickly stimulating the deployment of large amounts of RE generation. Although the discussion is aimed primarily at decision makers who have decided that a FIT policy best suits their needs, exploration of FIT policies can also help inform a choice among alternative renewable energy policies.

Good practice guide to internal flexibility policies in companies

OpenAIRE

Goudswaard, A.; Oeij, P.; Brugman, T.

2009-01-01

This report sets out to contribute to the present debate on the need for European companies and their workers to become more flexible and adaptable in the face of ongoing economic change and business restructuring. The guide should therefore provide useful and practical tips for company-level actors concerning the potential benefits of developing more flexible internal workplace policies. Equally, it has been developed to assist practitioners and social partners wishing to review and/or learn...

Activation of Rab GTPase Sec4 by its GEF Sec2 is required for prospore membrane formation during sporulation in yeast Saccharomyces cerevisiae.

Science.gov (United States)

Suda, Yasuyuki; Tachikawa, Hiroyuki; Inoue, Ichiro; Kurita, Tomokazu; Saito, Chieko; Kurokawa, Kazuo; Nakano, Akihiko; Irie, Kenji

2018-02-01

Sec2 activates Sec4 Rab GTPase as a guanine nucleotide exchange factor for the recruitment of downstream effectors to facilitate tethering and fusion of post-Golgi vesicles at the plasma membrane. During the meiosis and sporulation of budding yeast, post-Golgi vesicles are transported to and fused at the spindle pole body (SPB) to form a de novo membrane, called the prospore membrane. Previous studies have revealed the role of the SPB outer surface called the meiotic outer plaque (MOP) in docking and fusion of post-Golgi vesicles. However, the upstream molecular machinery for post-Golgi vesicular fusion that facilitates prospore membrane formation remains enigmatic. Here, we demonstrate that the GTP exchange factor for Sec4, Sec2, participates in the formation of the prospore membrane. A conditional mutant in which the SEC2 expression is shut off during sporulation showed sporulation defects. Inactivation of Sec2 caused Sec4 targeting defects along the prospore membranes, thereby causing insufficient targeting of downstream effectors and cargo proteins to the prospore membrane. These results suggest that the activation of Sec4 by Sec2 is required for the efficient supply of post-Golgi vesicles to the prospore membrane and thus for prospore membrane formation/extension and subsequent deposition of spore wall materials. © FEMS 2017. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

46 CFR Sec. 3 - Accounting for revenues.

Science.gov (United States)

2010-10-01

... 46 Shipping 8 2010-10-01 2010-10-01 false Accounting for revenues. Sec. 3 Section 3 Shipping... FINANCIAL TRANSACTIONS UNDER AGENCY AGREEMENTS Accounting for Revenues Sec. 3 Accounting for revenues. (a... shipper, consignee, weight or measurement, freight rate and basis (whether the freight rate applies on...

What Should Guide Health Policy? A Perspective Beyond Politics.

Science.gov (United States)

Kirch, Darrell G; Ast, Cori

2017-09-01

As the U.S. electorate has become increasingly polarized, these divisions are poised to shape legislative and regulatory work in the years ahead. For those whose focus is on the public goods of health care for all, the advancement of science through rigorous research, and the contribution of higher education to the continual improvement of the nation's workforce, there is profound uncertainty about the future. There are several pressing questions facing the nation and academic medicine, including the future of affordable, accessible insurance; acceptance of scientific evidence; sustainable learning and teaching methodologies; and the well-being and preparation of the nation's health workforce to care for an increasingly diverse nation. For those in academic medicine and policy making alike, the authors propose a framework, grounded in scientific evidence and guided by clinical ethics, for designing and evaluating health policy solutions for these and other pressing questions.

Allergies And Asthma : Employing Principles Of Social Justice As A Guide In Public Health Policy Development

Directory of Open Access Journals (Sweden)

Jason Behrmann

2010-05-01

Full Text Available The growing epidemic of allergy and allergy-induced asthma poses a significant challenge to population health. This article, written for a target audience of policy-makers in public health, aims to contribute to the development of policies to counter allergy morbidities by demonstrat- ing how principles of social justice can guide public health initiatives in reducing allergy and asthma triggers. Following a discussion of why theories of social justice have utility in analyzing allergy, a step-wise policy assessment protocol formulated on Rawlsian principles of social jus- tice is presented. This protocol can serve as a tool to aid in prioritizing public health initiatives and identifying ethically problematic policies that necessitate reform. Criteria for policy assess- ment include: 1 whether a tentative public health intervention would provide equal health ben- efit to a range of allergy and asthma sufferers, 2 whether targeting initiatives towards particu- lar societal groups is merited based on the notion of ‘worst-off status’ of certain population seg- ments, and 3 whether targeted policies have the potential for stigmatization. The article con- cludes by analyzing three examples of policies used in reducing allergy and asthma triggers in order to convey the general thought process underlying the use of the assessment protocol, which public health officials could replicate as a guide in actual, region-specific policy development.

ASN guide project. Safety policy and management in INBs (base nuclear installations)

International Nuclear Information System (INIS)

2010-01-01

This guide presents the recommendations of the French Nuclear Safety Authority (ASN) in the field of safety policy and management (PMS) for base nuclear installations (INBs). It gives an overview and comments of some prescriptions of the so-called INB order and PMS decision. These regulatory texts define a framework for provisions any INB operator must implement to establish his safety policy, to define and implement a system which allows the safety to be maintained, the improvement of his INB safety to be permanently looked for. The following issues are addressed: operator's safety policy, identification of elements important for safety, of activities pertaining to safety, and of associated requirements, safety management organization and system, management of activities pertaining to safety, documentation and archiving

A Policymaker's Guide to Feed-in Tariff Policy Design

Energy Technology Data Exchange (ETDEWEB)

Couture, Toby D. [E3 Analytics, Berlin (Germany); Cory, Karlynn [National Renewable Energy Lab. (NREL), Golden, CO (United States); Kreycik, Claire [National Renewable Energy Lab. (NREL), Golden, CO (United States); Williams, Emily [U.S. Dept. of Energy, Washington, DC (United States)

2010-07-01

Feed-in tariffs (FITs) are the most widely used renewable energy policy in the world for driving accelerating renewable energy (RE) deployment, accounting for a greater share of RE development than either tax incentives or renewable portfolio standard (RPS) policies. FITs have generated significant RE deployment, helping bring the countries that have implemented them successfully to the forefront of the global RE industry. In the European Union (EU), FIT policies have led to the deployment of more than 15,000 MW of solar photovoltaic (PV) power and more than 55,000 MW of wind power between 2000 and the end of 2009. In total, FITs are responsible for approximately 75% of global PV and 45% of global wind deployment. Countries such as Germany, in particular, have demonstrated that FITs can be used as a powerful policy tool to drive RE deployment and help meet combined energy security and emissions reductions objectives. This policymaker’s guide provides a detailed analysis of FIT policy design and implementation and identifies a set of best practices that have been effective at quickly stimulating the deployment of large amounts of RE generation.

To Strengthen Policy Guiding Regionalization of Occupational Programs in New Jersey County Community Colleges. A Report.

Science.gov (United States)

Martorana, S. V.; And Others

In 1985 a project was developed to strengthen policy guiding regionalization of occupational programs in New Jersey county community colleges. The project had three major goals: to establish a policy for the regionalization of selected occupational programs offered by the colleges; to describe ways that programs could be identified for regional…

A health app developer's guide to law and policy: a multi-sector policy analysis.

Science.gov (United States)

Parker, Lisa; Karliychuk, Tanya; Gillies, Donna; Mintzes, Barbara; Raven, Melissa; Grundy, Quinn

2017-10-02

Apps targeted at health and wellbeing sit in a rapidly growing industry associated with widespread optimism about their potential to deliver accessible and cost-effective healthcare. App developers might not be aware of all the regulatory requirements and best practice principles are emergent. Health apps are regulated in order to minimise their potential for harm due to, for example, loss of personal health privacy, financial costs, and health harms from delayed or unnecessary diagnosis, monitoring and treatment. We aimed to produce a comprehensive guide to assist app developers in producing health apps that are legally compliant and in keeping with high professional standards of user protection. We conducted a case study analysis of the Australian and related international policy environment for mental health apps to identify relevant sectors, policy actors, and policy solutions. We identified 29 policies produced by governments and non-government organisations that provide oversight of health apps. In consultation with stakeholders, we developed an interactive tool targeted at app developers, summarising key features of the policy environment and highlighting legislative, industry and professional standards around seven relevant domains: privacy, security, content, promotion and advertising, consumer finances, medical device efficacy and safety, and professional ethics. We annotated this developer guidance tool with information about: the relevance of each domain; existing legislative and non-legislative guidance; critiques of existing policy; recommendations for developers; and suggestions for other key stakeholders. We anticipate that mental health apps developed in accordance with this tool will be more likely to conform to regulatory requirements, protect consumer privacy, protect consumer finances, and deliver health benefit; and less likely to attract regulatory penalties, offend consumers and communities, mislead consumers, or deliver health harms. We

Energy efficiency survey in Nigeria. A guide to developing policy and legislation

Energy Technology Data Exchange (ETDEWEB)

Uyigue, Etiosa; Agho, Matthew; Edevbaro, Agharese; Godfrey, Ogbemudia Osamuyi; Uyigue, Osazee Paul; Okungbowa, Ose Golden

2009-09-15

In Nigeria, experts have asserted that Nigeria can save up to half of the energy currently consumed in the country if energy is efficiently utilized. The major challenge has been that energy policy in Nigeria has undermined the importance and gains of energy efficiency to the environment and economic growth. In the midst of the prevailing energy crisis in Nigeria, energy efficiency will play a pivotal role in ensuring access to energy. Efficiency is not only cheaper than all other options; it also leads to growth in jobs and personal income. By reducing energy bills, it frees up money that can be spent elsewhere in the economy. It appears that the concept of energy efficiency seems to be poorly developed in Nigeria. Having discovered the policy gaps in the Nigerian system on energy efficiency, the Community Research and Development Centre designed and embarked on a research that will help to provide guideline for developing policy and legislation in the energy sector. We discovered that there is absence of research materials and data that will guide and strengthen regulatory measures to use energy efficiently in Nigeria. Hence the research was embarked upon to elicit information that will guide the development of energy efficiency policy which will in turn strengthen regulatory measures to use energy efficiently in Nigeria. In this study, we are focusing on the management of electricity; though energy efficiency is applicable to other forms of energy. Another objective of the study is to identify commercially and behaviorally low-cost ways of reducing energy consumption in the residential, public and private sectors in Nigeria. The information from this study, we believe will help to develop energy efficiency policy document applicable in Nigeria. The research will also help to identify renewable energy potential in the different regions of Nigeria. This document will also serve as a training manual for conferences and workshops.

14 CFR Sec. 1-6 - Accounting entities.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Accounting entities. Sec. 1-6 Section 1-6... REGULATIONS UNIFORM SYSTEM OF ACCOUNTS AND REPORTS FOR LARGE CERTIFICATED AIR CARRIERS General Accounting Provisions Sec. 1-6 Accounting entities. (a) Separate accounting records shall be maintained for each air...

14 CFR Sec. 2-4 - Accounting period.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Accounting period. Sec. 2-4 Section 2-4... REGULATIONS UNIFORM SYSTEM OF ACCOUNTS AND REPORTS FOR LARGE CERTIFICATED AIR CARRIERS General Accounting Provisions Sec. 2-4 Accounting period. (a) The accounting year of each air carrier subject to this Uniform...

The Dynamics of SecM-Induced Translational Stalling

Directory of Open Access Journals (Sweden)

Albert Tsai

2014-06-01

Full Text Available SecM is an E. coli secretion monitor capable of stalling translation on the prokaryotic ribosome without cofactors. Biochemical and structural studies have demonstrated that the SecM nascent chain interacts with the 50S subunit exit tunnel to inhibit peptide bond formation. However, the timescales and pathways of stalling on an mRNA remain undefined. To provide a dynamic mechanism for stalling, we directly tracked the dynamics of elongation on ribosomes translating the SecM stall sequence (FSTPVWISQAQGIRAGP using single-molecule fluorescence techniques. Within 1 min, three peptide-ribosome interactions work cooperatively over the last five codons of the SecM sequence, leading to severely impaired elongation rates beginning from the terminal proline and lasting four codons. Our results suggest that stalling is tightly linked to the dynamics of elongation and underscore the roles that the exit tunnel and nascent chain play in controlling fundamental steps in translation.

Secretome analysis defines the major role of SecDF in Staphylococcus aureus virulence.

Directory of Open Access Journals (Sweden)

Chantal Quiblier

Full Text Available The Sec pathway plays a prominent role in protein export and membrane insertion, including the secretion of major bacterial virulence determinants. The accessory Sec constituent SecDF has been proposed to contribute to protein export. Deletion of Staphylococcus aureus secDF has previously been shown to reduce resistance, to alter cell separation, and to change the expression of certain virulence factors. To analyse the impact of the secDF deletion in S. aureus on protein secretion, a quantitative secretome analysis was performed. Numerous Sec signal containing proteins involved in virulence were found to be decreased in the supernatant of the secDF mutant. However, two Sec-dependent hydrolases were increased in comparison to the wild type, suggesting additional indirect, regulatory effects to occur upon deletion of secDF. Adhesion, invasion, and cytotoxicity of the secDF mutant were reduced in human umbilical vein endothelial cells. Virulence was significantly reduced using a Galleria mellonella insect model. Altogether, SecDF is a promising therapeutic target for controlling S. aureus infections.

Analyzing personalized policies for online biometric verification.

Science.gov (United States)

Sadhwani, Apaar; Yang, Yan; Wein, Lawrence M

2014-01-01

Motivated by India's nationwide biometric program for social inclusion, we analyze verification (i.e., one-to-one matching) in the case where we possess similarity scores for 10 fingerprints and two irises between a resident's biometric images at enrollment and his biometric images during his first verification. At subsequent verifications, we allow individualized strategies based on these 12 scores: we acquire a subset of the 12 images, get new scores for this subset that quantify the similarity to the corresponding enrollment images, and use the likelihood ratio (i.e., the likelihood of observing these scores if the resident is genuine divided by the corresponding likelihood if the resident is an imposter) to decide whether a resident is genuine or an imposter. We also consider two-stage policies, where additional images are acquired in a second stage if the first-stage results are inconclusive. Using performance data from India's program, we develop a new probabilistic model for the joint distribution of the 12 similarity scores and find near-optimal individualized strategies that minimize the false reject rate (FRR) subject to constraints on the false accept rate (FAR) and mean verification delay for each resident. Our individualized policies achieve the same FRR as a policy that acquires (and optimally fuses) 12 biometrics for each resident, which represents a five (four, respectively) log reduction in FRR relative to fingerprint (iris, respectively) policies previously proposed for India's biometric program. The mean delay is [Formula: see text] sec for our proposed policy, compared to 30 sec for a policy that acquires one fingerprint and 107 sec for a policy that acquires all 12 biometrics. This policy acquires iris scans from 32-41% of residents (depending on the FAR) and acquires an average of 1.3 fingerprints per resident.

N-acetylation and phosphorylation of Sec complex subunits in the ER membrane

Directory of Open Access Journals (Sweden)

Soromani Christina

2012-12-01

Full Text Available Abstract Background Covalent modifications of proteins provide a mechanism to control protein function. Here, we have investigated modifications of the heptameric Sec complex which is responsible for post-translational protein import into the endoplasmic reticulum (ER. It consists of the Sec61 complex (Sec61p, Sbh1p, Sss1p which on its own mediates cotranslational protein import into the ER and the Sec63 complex (Sec63p, Sec62p, Sec71p, Sec72p. Little is known about the biogenesis and regulation of individual Sec complex subunits. Results We show that Sbh1p when it is part of the Sec61 complex is phosphorylated on T5 which is flanked by proline residues. The phosphorylation site is conserved in mammalian Sec61ß, but only partially in birds, and not in other vertebrates or unicellular eukaryotes, suggesting convergent evolution. Mutation of T5 to A did not affect the ability of mutant Sbh1p to complement the growth defect in a Δsbh1Δsbh2 strain, and did not result in a hypophosphorylated protein which shows that alternate sites can be used by the T5 kinase. A survey of yeast phosphoproteome data shows that Sbh1p can be phosphorylated on multiple sites which are organized in two patches, one at the N-terminus of its cytosolic domain, the other proximal to the transmembrane domain. Surprisingly, although N-acetylation has been shown to interfere with ER targeting, we found that both Sbh1p and Sec62p are cotranslationally N-acetylated by NatA, and N-acetyl-proteome data indicate that Sec61p is modified by the same enzyme. Mutation of the N-acetylation site, however, did not affect Sec62p function in posttranslational protein import into the ER. Disabling NatA resulted in growth retardation, but not in co- or posttranslational translocation defects or instability of Sec62p or Sbh1p. Conclusions We conclude that N-acetylation of transmembrane and tail-anchored proteins does not interfere with their ER-targeting, and that Sbh1p phosphorylation on T5

Tests of SEC stability in high flux proton beams

International Nuclear Information System (INIS)

Agoritsas, V.; Witkover, R.L.

1979-01-01

The Secondary Emission Chamber (SEC) is used to measure the beam intensity in slow extracted beam channels of proton synchrotrons around the world. With the improvements in machine intensity, these monitors have been exposed to higher flux conditions than in the past. A change in sensitivity of up to 25% has been observed in the region around the beam spot. Using SEC's of special construction, a series of tests was performed at FNAL, BNL-AGS and CERN-PS. The results of these tests and conclusions about the construction of more stable SEC's are presented

Disruption of the Sec24d gene results in early embryonic lethality in the mouse.

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Andrea C Baines

Full Text Available Transport of newly synthesized proteins from the endoplasmic reticulum (ER to the Golgi is mediated by the coat protein complex COPII. The inner coat of COPII is assembled from heterodimers of SEC23 and SEC24. Though mice with mutations in one of the four Sec24 paralogs, Sec24b, exhibit a neural tube closure defect, deficiency in humans or mice has not yet been described for any of the other Sec24 paralogs. We now report characterization of mice with targeted disruption of Sec24d. Early embryonic lethality is observed in mice completely deficient in SEC24D, while a hypomorphic Sec24d allele permits survival to mid-embryogenesis. Mice haploinsufficient for Sec24d exhibit no phenotypic abnormality. A BAC transgene containing Sec24d rescues the embryonic lethality observed in Sec24d-null mice. These results demonstrate an absolute requirement for SEC24D expression in early mammalian development that is not compensated by the other three Sec24 paralogs. The early embryonic lethality resulting from loss of SEC24D in mice contrasts with the previously reported mild skeletal phenotype of SEC24D deficiency in zebrafish and restricted neural tube phenotype of SEC24B deficiency in mice. Taken together, these observations suggest that the multiple Sec24 paralogs have developed distinct functions over the course of vertebrate evolution.

Cell death by SecTRAPs: thioredoxin reductase as a prooxidant killer of cells.

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Karin Anestål

Full Text Available BACKGROUND: SecTRAPs (selenium compromised thioredoxin reductase-derived apoptotic proteins can be formed from the selenoprotein thioredoxin reductase (TrxR by targeting of its selenocysteine (Sec residue with electrophiles, or by its removal through C-terminal truncation. SecTRAPs are devoid of thioredoxin reductase activity but can induce rapid cell death in cultured cancer cell lines by a gain of function. PRINCIPAL FINDINGS: Both human and rat SecTRAPs killed human A549 and HeLa cells. The cell death displayed both apoptotic and necrotic features. It did not require novel protein synthesis nor did it show extensive nuclear fragmentation, but it was attenuated by use of caspase inhibitors. The redox active disulfide/dithiol motif in the N-terminal domain of TrxR had to be maintained for manifestation of SecTRAP cytotoxicity. Stopped-flow kinetics showed that NADPH can reduce the FAD moiety in SecTRAPs at similar rates as in native TrxR and purified SecTRAPs could maintain NADPH oxidase activity, which was accelerated by low molecular weight substrates such as juglone. In a cellular context, SecTRAPs triggered extensive formation of reactive oxygen species (ROS and consequently antioxidants could protect against the cell killing by SecTRAPs. CONCLUSIONS: We conclude that formation of SecTRAPs could contribute to the cytotoxicity seen upon exposure of cells to electrophilic agents targeting TrxR. SecTRAPs are prooxidant killers of cells, triggering mechanisms beyond those of a mere loss of thioredoxin reductase activity.

14 CFR Sec. 2-5 - Revenue and accounting practices.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Revenue and accounting practices. Sec. 2-5... General Accounting Provisions Sec. 2-5 Revenue and accounting practices. (a) Revenue accounting practices... physically verify the reliability of its passenger revenue accounting practice at least once each accounting...

SEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion

Science.gov (United States)

Chen, Xiao-Wei; Wang, He; Bajaj, Kanika; Zhang, Pengcheng; Meng, Zhuo-Xian; Ma, Danjun; Bai, Yongsheng; Liu, Hui-Hui; Adams, Elizabeth; Baines, Andrea; Yu, Genggeng; Sartor, Maureen A; Zhang, Bin; Yi, Zhengping; Lin, Jiandie; Young, Stephen G; Schekman, Randy; Ginsburg, David

2013-01-01

The secretory pathway of eukaryotic cells packages cargo proteins into COPII-coated vesicles for transport from the endoplasmic reticulum (ER) to the Golgi. We now report that complete genetic deficiency for the COPII component SEC24A is compatible with normal survival and development in the mouse, despite the fundamental role of SEC24 in COPII vesicle formation and cargo recruitment. However, these animals exhibit markedly reduced plasma cholesterol, with mutations in Apoe and Ldlr epistatic to Sec24a, suggesting a receptor-mediated lipoprotein clearance mechanism. Consistent with these data, hepatic LDLR levels are up-regulated in SEC24A-deficient cells as a consequence of specific dependence of PCSK9, a negative regulator of LDLR, on SEC24A for efficient exit from the ER. Our findings also identify partial overlap in cargo selectivity between SEC24A and SEC24B, suggesting a previously unappreciated heterogeneity in the recruitment of secretory proteins to the COPII vesicles that extends to soluble as well as trans-membrane cargoes. DOI: http://dx.doi.org/10.7554/eLife.00444.001 PMID:23580231

Study of guided modes in three-dimensional composites

Science.gov (United States)

Baste, S.; Gerard, A.

The propagation of elastic waves in a three-dimensional carbon-carbon composite is modeled with a mixed variational method, using the Bloch or Floquet theories and the Hellinger-Reissner function for two independent fields. The model of the equivalent homogeneous material only exists below a cut-off frequency of about 600 kHz. The existence below the cut-off frequency of two guided waves can account for the presence of a slow guided wave on either side of the cut-off frequency. Optical modes are generated at low frequencies, and can attain high velocites (rapid guided modes of 15,000 m/sec).

Mechanisms of Rose Bengal inhibition on SecA ATPase and ion channel activities.

Science.gov (United States)

Hsieh, Ying-Hsin; Huang, Ying-Ju; Jin, Jin-Shan; Yu, Liyan; Yang, Hsiuchin; Jiang, Chun; Wang, Binghe; Tai, Phang C

2014-11-14

SecA is an essential protein possessing ATPase activity in bacterial protein translocation for which Rose Bengal (RB) is the first reported sub-micromolar inhibitor in ATPase activity and protein translocation. Here, we examined the mechanisms of inhibition on various forms of SecA ATPase by conventional enzymatic assays, and by monitoring the SecA-dependent channel activity in the semi-physiological system in cells. We build on the previous observation that SecA with liposomes form active protein-conducting channels in the oocytes. Such ion channel activity is enhanced by purified Escherichia coli SecYEG-SecDF·YajC liposome complexes. Inhibition by RB could be monitored, providing correlation of in vitro activity and intact cell functionality. In this work, we found the intrinsic SecA ATPase is inhibited by RB competitively at low ATP concentration, and non-competitively at high ATP concentrations while the translocation ATPase with precursors and SecYEG is inhibited non-competitively by RB. The Inhibition by RB on SecA channel activity in the oocytes with exogenous ATP-Mg(2+), mimicking translocation ATPase activity, is also non-competitive. The non-competitive inhibition on channel activity has also been observed with SecA from other bacteria which otherwise would be difficult to examine without the cognate precursors and membranes. Copyright © 2014 Elsevier Inc. All rights reserved.

14 CFR Sec. 1-4 - System of accounts coding.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false System of accounts coding. Sec. 1-4 Section... General Accounting Provisions Sec. 1-4 System of accounts coding. (a) A four digit control number is assigned for each balance sheet and profit and loss account. Each balance sheet account is numbered...

Financial Journalism under Fire: The SEC and Newsroom Ethics.

Science.gov (United States)

Spellman, Robert L.

Although noting that the Securities and Exchange Commission (SEC) has been a valuable ally of journalists, this paper suggests that recent efforts of the SEC in prosecuting the case of R. Foster Winans, Jr., a former writer for the "Wall Street Journal," may be unconstitutional. Following an introduction to the First Amendment issues…

46 CFR Sec. 2 - Description of NSA-WORKSMALREP Contract.

Science.gov (United States)

2010-10-01

... 46 Shipping 8 2010-10-01 2010-10-01 false Description of NSA-WORKSMALREP Contract. Sec. 2 Section... REPAIRS-NSA-WORKSMALREP Sec. 2 Description of NSA-WORKSMALREP Contract. This is an individual fixed price contract which may be awarded to any firm not holding an NSA-LUMPSUMREP Contract, as a result of formal...

46 CFR Sec. 5 - Measures to protect ship's payrolls.

Science.gov (United States)

2010-10-01

... 46 Shipping 8 2010-10-01 2010-10-01 false Measures to protect ship's payrolls. Sec. 5 Section 5... SHIP'S PERSONNEL Sec. 5 Measures to protect ship's payrolls. (a) General Agents are not required to consider the amount of the payroll delivered to the Master at the conclusion of a voyage in determining the...

Digital Citizenship Policy Development Guide

Science.gov (United States)

Alberta Education, 2012

2012-01-01

Education leaders are re-examining acceptable use policies in light of the increasing use of highly mobile information technologies. While acceptable use policies were developed to manage and control behaviour, a digital citizenship policy takes a more comprehensive approach by recognizing the important role of education in preparing digital…

46 CFR Sec. 10 - Bonds.

Science.gov (United States)

2010-10-01

... REPAIRS UNDER NATIONAL SHIPPING AUTHORITY MASTER LUMP SUM REPAIR CONTRACT-NSA-LUMPSUMREP Sec. 10 Bonds. (a... awarded work and the furnishing of the performance and payment bonds required by Article 14 of the NSA... of the NSA-LUMPSUMREP Contract, the standard form of individual performance bond (Standard Form 25...

Domain interactions of the peripheral preprotein translocase subunit SecA

NARCIS (Netherlands)

Blaauwen, T.den; Fekkes, P.; de Wit, J.G.; Kuiper, W.; Driessen, A.J.M.

1996-01-01

The homodimeric SecA protein is the peripheral subunit of the preprotein translocase in bacteria. It binds the preprotein and promotes its translocation across the bacterial cytoplasmic membrane by nucleotide modulated coinsertion and deinsertion into the membrane, SecA has two essential nucleotide

A Policy Guide on Integrated Care (PGIC: Lessons Learned from EU Project INTEGRATE and Beyond

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Liesbeth Borgermans

2017-09-01

Full Text Available Efforts are underway in many European countries to channel efforts into creating improved integrated health and social care services. But most countries lack a strategic plan that is sustainable over time, and that reflects a comprehensive systems perspective. The Policy Guide on Integrated Care (PGIC as presented in this paper resulted from experiences with the EU Project INTEGRATE and our own work with healthcare reform for patients with chronic conditions at the national and international level. This project is one of the largest EU funded projects on Integrated Care, conducted over a four-year period (2012–2016 and included partners from nine European countries. Project Integrate aimed to gain insights into the leadership, management and delivery of integrated care to support European care systems to respond to the challenges of ageing populations and the rise of people living with long-term conditions. The objective of this paper is to describe the PGIC as both a tool and a reasoning flow that aims at supporting policy makers at the national and international level with the development and implementation of integrated care. Any Policy Guide on Integrated should build upon three building blocks, being a mission, vision and a strategy that aim at capturing the large amount of factors that directly or indirectly influence the successful development of integrated care.

A Policy Guide on Integrated Care (PGIC): Lessons Learned from EU Project INTEGRATE and Beyond.

Science.gov (United States)

Borgermans, Liesbeth; Devroey, Dirk

2017-09-25

Efforts are underway in many European countries to channel efforts into creating improved integrated health and social care services. But most countries lack a strategic plan that is sustainable over time, and that reflects a comprehensive systems perspective. The Policy Guide on Integrated Care (PGIC) as presented in this paper resulted from experiences with the EU Project INTEGRATE and our own work with healthcare reform for patients with chronic conditions at the national and international level. This project is one of the largest EU funded projects on Integrated Care, conducted over a four-year period (2012-2016) and included partners from nine European countries. Project Integrate aimed to gain insights into the leadership, management and delivery of integrated care to support European care systems to respond to the challenges of ageing populations and the rise of people living with long-term conditions. The objective of this paper is to describe the PGIC as both a tool and a reasoning flow that aims at supporting policy makers at the national and international level with the development and implementation of integrated care. Any Policy Guide on Integrated should build upon three building blocks, being a mission, vision and a strategy that aim at capturing the large amount of factors that directly or indirectly influence the successful development of integrated care.

Protein Export by the Mycobacterial SecA2 System Is Determined by the Preprotein Mature Domain

Science.gov (United States)

Feltcher, Meghan E.; Gibbons, Henry S.; Ligon, Lauren S.

2013-01-01

At the core of the bacterial general secretion (Sec) pathway is the SecA ATPase, which powers translocation of unfolded preproteins containing Sec signal sequences through the SecYEG membrane channel. Mycobacteria have two nonredundant SecA homologs: SecA1 and SecA2. While the essential SecA1 handles “housekeeping” export, the nonessential SecA2 exports a subset of proteins and is required for Mycobacterium tuberculosis virulence. Currently, it is not understood how SecA2 contributes to Sec export in mycobacteria. In this study, we focused on identifying the features of two SecA2 substrates that target them to SecA2 for export, the Ms1704 and Ms1712 lipoproteins of the model organism Mycobacterium smegmatis. We found that the mature domains of Ms1704 and Ms1712, not the N-terminal signal sequences, confer SecA2-dependent export. We also demonstrated that the lipid modification and the extreme N terminus of the mature protein do not impart the requirement for SecA2 in export. We further showed that the Ms1704 mature domain can be efficiently exported by the twin-arginine translocation (Tat) pathway. Because the Tat system exports only folded proteins, this result implies that SecA2 substrates can fold in the cytoplasm and suggests a putative role of SecA2 in enabling export of such proteins. Thus, the mycobacterial SecA2 system may represent another way that bacteria solve the problem of exporting proteins that can fold in the cytoplasm. PMID:23204463

A study of SEC chromatograms on the basis of polymer structure properties

DEFF Research Database (Denmark)

Size Exclusion Chromatography (SEC), widely used in polymer laboratories, provides a convenient method for the determination of full molecular weight distribution (MWD) of polymers. For linear homogeneous polymer samples, the procedure to estimate the true MWD based on the elution curve of SEC has...... already been well established, while for nonlinear polymer samples and mixtures of linear and nonlinear polymers, the measured SEC data are often used just qualitatively. The SEC separation process is rather complicated, and a detailed study using finite element method and/or Brownian Dynamics simulation...... technique is rather difficult without oversimplifying the problem dramatically. However, it has been known for long that SEC separates polymer molecules according to their size in dilute solutions, and experimental studies with well-defined linear and nonlinear polymer samples have shown that a universal...

A Study of SEC Chromatograms on the basis of Polymer Structure Calculations

DEFF Research Database (Denmark)

Hassager, Ole; Wang, Yanwei

2007-01-01

Size Exclusion Chromatography (SEC), widely used in polymer laboratories, provides a convenient method for the determination of full molecular weight distribution (MWD) of polymers. For linear homogeneous polymer samples, the procedure to estimate the true MWD based on the elution curve of SEC has...... already been well established, while for nonlinear polymer samples and mixtures of linear and nonlinear polymers, the measured SEC data are often used just qualitatively. The SEC separation process is rather complicated, and a detailed study using finite element method and/or Brownian Dynamics simulation...... technique is rather difficult without oversimplifying the problem dramatically. However, it has been known for long that SEC separates polymer molecules according to their size in dilute solutions, and experimental studies with well-defined linear and nonlinear polymer samples have shown that a universal...

Acceptable Use Policies in a Web 2.0 & Mobile Era: A Guide for School Districts

Science.gov (United States)

Consortium for School Networking (NJ1), 2011

2011-01-01

Web 2.0 applications and mobile Internet devices have added new issues to the safety/access situation for schools. The purpose of this guide is to assist school districts in developing, rethinking, or revising Internet policies as a consequence of the emergence of Web 2.0, and the growing pervasiveness of smart phone use. The Consortium for School…

Predictive validity of examinations at the Secondary Education Certificate (SEC) level

OpenAIRE

Farrugia, Josette; Ventura, Frank

2007-01-01

This paper presents the predictive validity of results obtained by 16-year-old Maltese students in the May 2004 Secondary Education Certificate (SEC) examinations in Biology, Chemistry, Physics, Mathematics, Computing, English and Maltese for the Advanced level examinations in these subjects taken by the same students two years later. The study checks whether the SEC level is a good foundation for the higher level, the likelihood of obtaining a high grade at A-level from particular SEC result...

46 CFR Sec. 12 - Disposition of removed equipment and scrap.

Science.gov (United States)

2010-10-01

... 46 Shipping 8 2010-10-01 2010-10-01 false Disposition of removed equipment and scrap. Sec. 12... CONTRACT-NSA-LUMPSUMREP Sec. 12 Disposition of removed equipment and scrap. (a) Article 8 of the NSA-LUMPSUMREP Contract provides that any ship equipment, fuel, lube oil, supplies, stores, furniture, fixtures...

Moderate expression of SEC16 increases protein secretion by Saccharomyces cerevisiae

DEFF Research Database (Denmark)

Bao, Jichen; Huang, Mingtao; Petranovic, Dina

2017-01-01

in yeast, by moderately overexpressing SEC16, which is involved in protein translocation from the endoplasmic reticulum to the Golgi apparatus. The moderate overexpression of SEC16 increased α-amylase secretion by generating more endoplasmic reticulum exit sites. The production of reactive oxygen species...... were observed. Finally, the moderate overexpression of SEC16 was shown to improve the secretion of two other recombinant proteins, Trichoderma reesei endoglucanase I and Rhizopus oryzae glucan-1,4-α-glucosidase, indicating that this mechanism is of general relevance....

Characterization of Comb-Shaped Copolymers by Multidetection SEC, DLS and SANS

Directory of Open Access Journals (Sweden)

Giulia Gelardi

2017-02-01

Full Text Available PolyCarboxylate ether-based superplasticizers (PCEs are a type of comb-shaped copolymers used as polymeric dispersants in cementitious materials. PCEs have a high degree of dispersity, which limits the suitability of conventional characterization techniques, such as Size Exclusion Chromatography (SEC. Properties of PCEs strongly depend on their molecular structure and a comprehensive characterization is needed to fully understand the structure–property relationships. PCEs with well-defined molecular structures were synthesized to study their solution conformation by SEC and scattering techniques. The combined use of SEC, dynamic light scattering and small-angle neutron scattering allowed us to demonstrate the validity of a scaling law describing the radius of gyration of comb-shaped copolymers as a function of their molecular structure. Moreover, we show that the use of SEC with standard calibration, although widely spread, is not adequate for PCEs.

Contribution of SecDF to Staphylococcus aureus resistance and expression of virulence factors

Directory of Open Access Journals (Sweden)

Berger-Bächi Brigitte

2011-04-01

Full Text Available Abstract Background SecDF is an accessory factor of the conserved Sec protein translocation machinery and belongs to the resistance-nodulation-cell division (RND family of multidrug exporters. SecDF has been shown in Escherichia coli and Bacillus subtilis to be involved in the export of proteins. RND proteins can mediate resistance against various substances and might be of relevance in antimicrobial therapy. The role of RND proteins in Staphylococcus aureus has not yet been determined. Results Markerless deletion mutants were constructed to analyze the impact of the so far uncharacterized RND proteins in S. aureus. While the lack of Sa2056 and Sa2339 caused no phenotype regarding growth and resistance, the secDF mutant resulted in a pleiotropic phenotype. The secDF mutant was cold sensitive, but grew normally in rich medium at 37°C. Resistance to beta-lactams, glycopeptides and the RND substrates acriflavine, ethidium bromide and sodium dodecyl sulfate was reduced. The secDF mutant showed an aberrant cell separation and increased spontaneous and Triton X-100 induced autolysis, although the amounts of penicillin-binding proteins in the membrane were unchanged. The impact of secDF deletion on transcription and expression of specific virulence determinants varied: While coagulase transcription and activity were reduced, the opposite was observed for the autolysin Atl. A reduction of the transcription of the cell wall anchored protein A (spa was also found. The accumulation of SpA in the membrane and lowered amounts in the cell wall pointed to an impaired translocation. Conclusions The combination of different effects of secDF deletion on transcription, regulation and translocation lead to impaired cell division, reduced resistance and altered expression of virulence determinants suggesting SecDF to be of major relevance in S. aureus. Thus SecDF could be a potential target for the control and eradication of S. aureus in the future.

A Critical Analysis of the Role of SNARE Protein SEC22B in Antigen Cross-Presentation

Directory of Open Access Journals (Sweden)

S. Julia Wu

2017-06-01

Full Text Available Cross-presentation initiates immune responses against tumors and viral infections by presenting extracellular antigen on MHC I to activate CD8+ T cell-mediated cytotoxicity. In vitro studies in dendritic cells (DCs established SNARE protein SEC22B as a specific regulator of cross-presentation. However, the in vivo contribution of SEC22B to cross-presentation has not been tested. To address this, we generated DC-specific Sec22b knockout (CD11c-Cre Sec22bfl/fl mice. Contrary to the paradigm, SEC22B-deficient DCs efficiently cross-present both in vivo and in vitro. Although in vitro small hairpin RNA (shRNA-mediated Sec22b silencing in bone-marrow-derived dendritic cells (BMDCs reduced cross-presentation, treatment of SEC22B-deficient BMDCs with the same shRNA produced a similar defect, suggesting the Sec22b shRNA modulates cross-presentation through off-target effects. RNA sequencing of Sec22b shRNA-treated SEC22B-deficient BMDCs demonstrated several changes in the transcriptome. Our data demonstrate that contrary to the accepted model, SEC22B is not necessary for cross-presentation, cautioning against extrapolating phenotypes from knockdown studies alone.

SEC23B is required for pancreatic acinar cell function in adult mice

Science.gov (United States)

Khoriaty, Rami; Vogel, Nancy; Hoenerhoff, Mark J.; Sans, M. Dolors; Zhu, Guojing; Everett, Lesley; Nelson, Bradley; Durairaj, Haritha; McKnight, Brooke; Zhang, Bin; Ernst, Stephen A.; Ginsburg, David; Williams, John A.

2017-01-01

Mice with germline absence of SEC23B die perinatally, exhibiting massive pancreatic degeneration. We generated mice with tamoxifen-inducible, pancreatic acinar cell–specific Sec23b deletion. Inactivation of Sec23b exclusively in the pancreatic acinar cells of adult mice results in decreased overall pancreatic weights from pancreatic cell loss (decreased pancreatic DNA, RNA, and total protein content), as well as degeneration of exocrine cells, decreased zymogen granules, and alterations in the endoplasmic reticulum (ER), ranging from vesicular ER to markedly expanded cisternae with accumulation of moderate-density content or intracisternal granules. Acinar Sec23b deletion results in induction of ER stress and increased apoptosis in the pancreas, potentially explaining the loss of pancreatic cells and decreased pancreatic weight. These findings demonstrate that SEC23B is required for normal function of pancreatic acinar cells in adult mice. PMID:28539403

Competition between Sec- and TAT-dependent protein translocation in Escherichia coli

DEFF Research Database (Denmark)

Cristóbal, S.; de Gier, J.-W.; Nielsen, Henrik

1999-01-01

-routed into the TAT pathway, suggesting that Sec-targeting signals in Lep can override TAT-targeting information in the TorA signal peptide. We also show that the TorA signal peptide can be converted into a Sec-targeting signal peptide by increasing the hydrophobicity of its h-region. Thus, beyond the twin...... the TorA TAT-targeting signal peptide to the Sec-dependent inner membrane protein leader peptidase (Lep). We find that the soluble, periplasmic P2 domain from Lep is re-routed by the TorA signal peptide into the TAT pathway. In contrast, the full-length TorA–Lep fusion protein is not re...

SEC14 is a specific requirement for secretion of phospholipase B1 and pathogenicity of Cryptococcus neoformans

Science.gov (United States)

Chayakulkeeree, Methee; Johnston, Simon Andrew; Oei, Johanes Bijosono; Lev, Sophie; Williamson, Peter Richard; Wilson, Christabel Frewen; Zuo, Xiaoming; Leal, Ana Lusia; Vainstein, Marilene Henning; Meyer, Wieland; Sorrell, Tania Christine; May, Robin Charles; Djordjevic, Julianne Teresa

2011-01-01

Summary Secreted phospholipase B1 (CnPlb1) is essential for dissemination of Cryptococcus neoformans to the central nervous system (CNS) yet essential components of its secretion machinery remain to be elucidated. Using gene deletion analysis we demonstrate that CnPlb1 secretion is dependent on the CnSEC14 product, CnSec14-1p. CnSec14-1p is a homologue of the phosphatidylinositol transfer protein (PITP) ScSec14p, which is essential for secretion and viability in Saccharomyces cerevisiae. In contrast to CnPlb1, neither laccase 1 (Lac1)-induced melanization within the cell wall nor capsule induction were negatively impacted in CnSEC14-1 deletion mutants (CnΔsec14-1 and CnΔsec14-1CnΔsfh5). Similar to the CnPLB1 deletion mutant (CnΔplb1), CnΔsec14-1 was hypo-virulent in mice and did not disseminate to the CNS by day 14 post infection. Furthermore, macrophage expulsion of live CnΔsec14-1 and CnΔplb1 (vomocytosis) was reduced. Individual deletion of CnSEC14-2, a closely-related CnSEC14-1 homologue, and CnSFH5, a distantly-related SEC fourteen-like homologue, did not abrogate CnPlb1 secretion or virulence. However, reconstitution of CnΔsec14-1 with CnSEC14-1 or CnSEC14-2 restored both phenotypes, consistent with functional genetic redundancy. We conclude that CnPlb1 secretion is SEC14-dependent and that C. neoformans preferentially exports virulence determinants to the cell periphery via distinct pathways. We also demonstrate that CnPlb1 secretion is essential for vomocytosis. PMID:21453402

78 FR 53489 - SEC Advisory Committee on Small and Emerging Companies

Science.gov (United States)

2013-08-29

... Web site at www.sec.gov . Persons needing special accommodations to take part because of a disability... Commission will post all statements on the Advisory Committee's Web site ( http://www.sec.gov ./info/smallbus/acsec.shtml ). Statements also will be available for Web site viewing and printing in the Commission's...

78 FR 21432 - SEC Advisory Committee on Small and Emerging Companies

Science.gov (United States)

2013-04-10

... Web site at www.sec.gov . Persons needing special accommodations to take part because of a disability... all statements on the Advisory Committee's Web site ( http://www.sec.gov ./info/smallbus/acsec.shtml). Statements also will be available for Web site viewing and printing in the Commission's Public Reference Room...

Policy options evaluation tool for managed lanes (POET-ML) users guide and methodology description : Federal Highway Administration HOV lane performance

Science.gov (United States)

2008-12-01

Users guide for a sketch planning tool for exploring policy alternatives. It is intended for an audience of transportation professionals responsible for planning, designing, funding, operating, enforcing, monitoring, and managing HOV and HOT lanes...

Microprocessor-controlled tester for evaluation of the Self-Energized Credential System (SECS)

International Nuclear Information System (INIS)

Corlis, N.E.

1980-03-01

The Self-Energized Credential System (SECS) was developed for use in the Plutonium Protection System (PPS) installed at Hanford, Washington. Evaluation and development of the SECS system was enhanced by the use of a microprocessor-controlled portal tester. This tester used infrared (ir) beam sensors to provide information on the direction of travel of the credential wearer and to detect inoperative credentials. A printed record of the portal number, actual code read, time, and direction of the credential passage provided information essential to an assessment of the operability of the SECS

Assessment of health risks of policies

International Nuclear Information System (INIS)

Ádám, Balázs; Molnár, Ágnes; Ádány, Róza; Bianchi, Fabrizio; Bitenc, Katarina; Chereches, Razvan; Cori, Liliana; Fehr, Rainer; Kobza, Joanna; Kollarova, Jana

2014-01-01

The assessment of health risks of policies is an inevitable, although challenging prerequisite for the inclusion of health considerations in political decision making. The aim of our project was to develop a so far missing methodological guide for the assessment of the complex impact structure of policies. The guide was developed in a consensual way based on experiences gathered during the assessment of specific national policies selected by the partners of an EU project. Methodological considerations were discussed and summarized in workshops and pilot tested on the EU Health Strategy for finalization. The combined tool, which includes a textual guidance and a checklist, follows the top-down approach, that is, it guides the analysis of causal chains from the policy through related health determinants and risk factors to health outcomes. The tool discusses the most important practical issues of assessment by impact level. It emphasises the transparent identification and prioritisation of factors, the consideration of the feasibility of exposure and outcome assessment with special focus on quantification. The developed guide provides useful methodological instructions for the comprehensive assessment of health risks of policies that can be effectively used in the health impact assessment of policy proposals. - Highlights: • Methodological guide for the assessment of health risks of policies is introduced. • The tool is developed based on the experiences from several case studies. • The combined tool consists of a textual guidance and a checklist. • The top-down approach is followed through the levels of the full impact chain. • The guide provides assistance for the health impact assessment of policy proposals

Assessment of health risks of policies

Energy Technology Data Exchange (ETDEWEB)

Ádám, Balázs, E-mail: badam@cmss.sdu.dk [Unit for Health Promotion Research, Faculty of Health Sciences, University of Southern Denmark, Niels Bohrs Vej 9, DK-6700 Esbjerg (Denmark); Department of Preventive Medicine, Faculty of Public Health, University of Debrecen, P.O. Box 9, H-4012 Debrecen (Hungary); Molnár, Ágnes, E-mail: MolnarAg@smh.ca [Department of Preventive Medicine, Faculty of Public Health, University of Debrecen, P.O. Box 9, H-4012 Debrecen (Hungary); Centre for Research on Inner City Health, Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael' s Hospital, Victoria 209, Rm. 3-26.22, M5B 1C6 Toronto, Ontario (Canada); Ádány, Róza, E-mail: adany.roza@sph.unideb.hu [Department of Preventive Medicine, Faculty of Public Health, University of Debrecen, P.O. Box 9, H-4012 Debrecen (Hungary); Bianchi, Fabrizio, E-mail: Fabriepi@ifc.cnr.it [Unit of Environmental Epidemiology, Institute of Clinical Physiology, National Council of Research, Moruzzi 1, 56124 Pisa (Italy); Bitenc, Katarina, E-mail: katarina.bitenc@ivz-rs.si [National Institute of Public Health, Trubarjeva 2, SI-1000 Ljubljana (Slovenia); Chereches, Razvan, E-mail: razvan.m.chereches@gmail.com [Faculty of Political, Administrative and Communication Sciences, Babes-Bolyai University, Strada Mihail Kogalniceanu 1, 3400 Cluj (Romania); Cori, Liliana, E-mail: liliana.cori@ifc.cnr.it [Unit of Environmental Epidemiology, Institute of Clinical Physiology, National Council of Research, Moruzzi 1, 56124 Pisa (Italy); Fehr, Rainer, E-mail: rainer.fehr@uni-bielefeld.de [NRW Centre for Health, Westerfeldstr. 35-37, 33611 Bielefeld (Germany); Kobza, Joanna, E-mail: koga1@poczta.onet.pl [Public Health Department, Silesian Medical University, 18 Medykow Street, 40-752 Katowice (Poland); Kollarova, Jana, E-mail: janakollarova@yahoo.com [Department of Health Promotion, Regional Public Health Authority, Ipelska 1, 04011 Kosice (Slovakia); and others

2014-09-15

The assessment of health risks of policies is an inevitable, although challenging prerequisite for the inclusion of health considerations in political decision making. The aim of our project was to develop a so far missing methodological guide for the assessment of the complex impact structure of policies. The guide was developed in a consensual way based on experiences gathered during the assessment of specific national policies selected by the partners of an EU project. Methodological considerations were discussed and summarized in workshops and pilot tested on the EU Health Strategy for finalization. The combined tool, which includes a textual guidance and a checklist, follows the top-down approach, that is, it guides the analysis of causal chains from the policy through related health determinants and risk factors to health outcomes. The tool discusses the most important practical issues of assessment by impact level. It emphasises the transparent identification and prioritisation of factors, the consideration of the feasibility of exposure and outcome assessment with special focus on quantification. The developed guide provides useful methodological instructions for the comprehensive assessment of health risks of policies that can be effectively used in the health impact assessment of policy proposals. - Highlights: • Methodological guide for the assessment of health risks of policies is introduced. • The tool is developed based on the experiences from several case studies. • The combined tool consists of a textual guidance and a checklist. • The top-down approach is followed through the levels of the full impact chain. • The guide provides assistance for the health impact assessment of policy proposals.

75 FR 28667 - Joint CFTC-SEC Advisory Committee on Emerging Regulatory Issues

Science.gov (United States)

2010-05-21

... members, (iii) discussion of Committee agenda and organization; (iv) discussion of the Joint CFTC-SEC... make recommendations related to market structure issues that may have contributed to the volatility, as... ``Joint CFTC-SEC Advisory Committee'' to facilitate the organization and distribution of comments between...

Domain dynamics of the Bacillus subtilis peripheral preprotein translocase subunit SecA

NARCIS (Netherlands)

Driessen, A.J.M.; Ladbury, JE; Chowdhry, BZ

1998-01-01

The homodimeric SecA protein is the peripheral subunit of the preprotein translocase in bacteria. It promotes the preprotein translocation across the cytoplasmic membrane by nucleotide-modulated co-insertion and de-insertion into the integral domain of the translocase. SecA has two essential

46 CFR Sec. 5 - Responsibility for duplicating copies of NSA-WORKSMALREP Contract.

Science.gov (United States)

2010-10-01

... 46 Shipping 8 2010-10-01 2010-10-01 false Responsibility for duplicating copies of NSA-WORKSMALREP Contract. Sec. 5 Section 5 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL... INDIVIDUAL CONTRACT FOR MINOR REPAIRS-NSA-WORKSMALREP Sec. 5 Responsibility for duplicating copies of NSA...

The 12 item Social and Economic Conservatism Scale (SECS).

Science.gov (United States)

Everett, Jim A C

2013-01-01

Recent years have seen a surge in psychological research on the relationship between political ideology (particularly conservatism) and cognition, affect, behaviour, and even biology. Despite this flurry of investigation, however, there is as yet no accepted, validated, and widely used multi-item scale of conservatism that is concise, that is modern in its conceptualisation, and that includes both social and economic conservatism subscales. In this paper the 12-Item Social and Economic Conservatism Scale (SECS) is proposed and validated to help fill this gap. The SECS is suggested to be an important and useful tool for researchers working in political psychology.

Efficient secretion of small proteins in mammalian cells relies on Sec62-dependent posttranslational translocation

Science.gov (United States)

Lakkaraju, Asvin K. K.; Thankappan, Ratheeshkumar; Mary, Camille; Garrison, Jennifer L.; Taunton, Jack; Strub, Katharina

2012-01-01

Mammalian cells secrete a large number of small proteins, but their mode of translocation into the endoplasmic reticulum is not fully understood. Cotranslational translocation was expected to be inefficient due to the small time window for signal sequence recognition by the signal recognition particle (SRP). Impairing the SRP pathway and reducing cellular levels of the translocon component Sec62 by RNA interference, we found an alternate, Sec62-dependent translocation path in mammalian cells required for the efficient translocation of small proteins with N-terminal signal sequences. The Sec62-dependent translocation occurs posttranslationally via the Sec61 translocon and requires ATP. We classified preproteins into three groups: 1) those that comprise ≤100 amino acids are strongly dependent on Sec62 for efficient translocation; 2) those in the size range of 120–160 amino acids use the SRP pathway, albeit inefficiently, and therefore rely on Sec62 for efficient translocation; and 3) those larger than 160 amino acids depend on the SRP pathway to preserve a transient translocation competence independent of Sec62. Thus, unlike in yeast, the Sec62-dependent translocation pathway in mammalian cells serves mainly as a fail-safe mechanism to ensure efficient secretion of small proteins and provides cells with an opportunity to regulate secretion of small proteins independent of the SRP pathway. PMID:22648169

12,000 l/sec cryopump for hydrogen gas

International Nuclear Information System (INIS)

Shibata, Takemasa; Matsuda, Shinzaburo; Shirakata, Hirofumi; Saito, Masaki; Mizuno, Masayasu.

1978-08-01

In the neutral beam injector of JT-60, cryogenic pumps with pumping rate 10 6 l/sec for hydrogen will be installed in the beam lines. To develop the cryopumps a small-scale pump of 12,000 l/sec was made and its fundamental pumping characteristics were measured. The cryogenic pump consists of liquid helium cooled panel, liquid nitrogen cooled chevron and radiation shields. The cryopanel is cylindrical form and the chevron is arranged concentrically within it. The measured pumping rate agrees with the design one. The pumping rate is not lowered by 30 Torr.l/cm 2 on the cryopanel. Liquid helium consumption rate was also measured and the pressure rise in the vacuum chamber in reactivation of the cryopanel was observed. (auth.)

Affording Sustainability: Adopting a Theory of Affordances as a Guiding Heuristic for Environmental Policy

Directory of Open Access Journals (Sweden)

Roope O. Kaaronen

2017-11-01

Full Text Available Human behavior is an underlying cause for many of the ecological crises faced in the 21st century, and there is no escaping from the fact that widespread behavior change is necessary for socio-ecological systems to take a sustainable turn. Whilst making people and communities behave sustainably is a fundamental objective for environmental policy, behavior change interventions and policies are often implemented from a very limited non-systemic perspective. Environmental policy-makers and psychologists alike often reduce cognition ‘to the brain,’ focusing only to a minor extent on how everyday environments systemically afford pro-environmental behavior. Symptomatic of this are the widely prevalent attitude–action, value–action or knowledge–action gaps, understood in this paper as the gulfs lying between sustainable thinking and behavior due to lack of affordances. I suggest that by adopting a theory of affordances as a guiding heuristic, environmental policy-makers are better equipped to promote policies that translate sustainable thinking into sustainable behavior, often self-reinforcingly, and have better conceptual tools to nudge our socio–ecological system toward a sustainable turn. Affordance theory, which studies the relations between abilities to perceive and act and environmental features, is shown to provide a systemic framework for analyzing environmental policies and the ecology of human behavior. This facilitates the location and activation of leverage points for systemic policy interventions, which can help socio–ecological systems to learn to adapt to more sustainable habits. Affordance theory is presented to be applicable and pertinent to technically all nested levels of socio–ecological systems from the studies of sustainable objects and households to sustainable urban environments, making it an immensely versatile conceptual policy tool. Finally, affordance theory is also discussed from a participatory perspective

Affording Sustainability: Adopting a Theory of Affordances as a Guiding Heuristic for Environmental Policy.

Science.gov (United States)

Kaaronen, Roope O

2017-01-01

Human behavior is an underlying cause for many of the ecological crises faced in the 21st century, and there is no escaping from the fact that widespread behavior change is necessary for socio-ecological systems to take a sustainable turn. Whilst making people and communities behave sustainably is a fundamental objective for environmental policy, behavior change interventions and policies are often implemented from a very limited non-systemic perspective. Environmental policy-makers and psychologists alike often reduce cognition 'to the brain,' focusing only to a minor extent on how everyday environments systemically afford pro-environmental behavior. Symptomatic of this are the widely prevalent attitude-action, value-action or knowledge-action gaps, understood in this paper as the gulfs lying between sustainable thinking and behavior due to lack of affordances. I suggest that by adopting a theory of affordances as a guiding heuristic, environmental policy-makers are better equipped to promote policies that translate sustainable thinking into sustainable behavior, often self-reinforcingly, and have better conceptual tools to nudge our socio-ecological system toward a sustainable turn. Affordance theory, which studies the relations between abilities to perceive and act and environmental features, is shown to provide a systemic framework for analyzing environmental policies and the ecology of human behavior. This facilitates the location and activation of leverage points for systemic policy interventions, which can help socio-ecological systems to learn to adapt to more sustainable habits. Affordance theory is presented to be applicable and pertinent to technically all nested levels of socio-ecological systems from the studies of sustainable objects and households to sustainable urban environments, making it an immensely versatile conceptual policy tool. Finally, affordance theory is also discussed from a participatory perspective. Increasing the fit between local

Affording Sustainability: Adopting a Theory of Affordances as a Guiding Heuristic for Environmental Policy

Science.gov (United States)

Kaaronen, Roope O.

2017-01-01

Human behavior is an underlying cause for many of the ecological crises faced in the 21st century, and there is no escaping from the fact that widespread behavior change is necessary for socio-ecological systems to take a sustainable turn. Whilst making people and communities behave sustainably is a fundamental objective for environmental policy, behavior change interventions and policies are often implemented from a very limited non-systemic perspective. Environmental policy-makers and psychologists alike often reduce cognition ‘to the brain,’ focusing only to a minor extent on how everyday environments systemically afford pro-environmental behavior. Symptomatic of this are the widely prevalent attitude–action, value–action or knowledge–action gaps, understood in this paper as the gulfs lying between sustainable thinking and behavior due to lack of affordances. I suggest that by adopting a theory of affordances as a guiding heuristic, environmental policy-makers are better equipped to promote policies that translate sustainable thinking into sustainable behavior, often self-reinforcingly, and have better conceptual tools to nudge our socio–ecological system toward a sustainable turn. Affordance theory, which studies the relations between abilities to perceive and act and environmental features, is shown to provide a systemic framework for analyzing environmental policies and the ecology of human behavior. This facilitates the location and activation of leverage points for systemic policy interventions, which can help socio–ecological systems to learn to adapt to more sustainable habits. Affordance theory is presented to be applicable and pertinent to technically all nested levels of socio–ecological systems from the studies of sustainable objects and households to sustainable urban environments, making it an immensely versatile conceptual policy tool. Finally, affordance theory is also discussed from a participatory perspective. Increasing the fit

Science, Society, and America's Nuclear Waste: The Nuclear Waste Policy Act, Unit 3. Teacher Guide. Second Edition.

Science.gov (United States)

Department of Energy, Washington, DC. Office of Civilian Radioactive Waste Management, Washington, DC.

This guide is Unit 3 of the four-part series, Science, Society, and America's Nuclear Waste, produced by the U.S. Department of Energy's Office of Civilian Radioactive Waste Management. The goal of this unit is to identify the key elements of the United States' nuclear waste dilemma and introduce the Nuclear Waste Policy Act and the role of the…

Visa Security Policy: Roles of the Departments of State and Homeland Sec

Science.gov (United States)

2010-03-08

report pursuant to S. Res.137., committee print, 81st Cong., 2nd sess., April 20, 1950. 11 8 U.S.C. 1104 . 12 8 U.S.C. 1201. Visa Security Policy...Biometric 2-print fingerprint system (IDENT); and Advanced Passenger Information System ( APIS ). They also have access to selected legacy- INS

Shear-wave elastography for breast masses: local shear wave speed (m/sec versus Young modulus (kPa

Directory of Open Access Journals (Sweden)

Ji Hyun Youk

2014-01-01

<sec>

The quantitative elasticity values measured in kPa and m/sec on SWE showed good diagnostic performance. The specificity of the SD and AUC of the wSD measured in kPa were significantly higher than those measured in m/sec.

46 CFR Sec. 2 - Stand-by agreements.

Science.gov (United States)

2010-10-01

... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION B-CONTROL AND UTILIZATION OF PORTS OPERATING CONTRACT Sec. 2 Stand-by agreements. The Director NSA, Maritime Administration, in advance of an emergency, may negotiate... 1901) under the control of the Maritime Administration and allocated for long term exclusive use by the...

46 CFR Sec. 3 - When the NSA-WORKSMALREP Contract may be used.

Science.gov (United States)

2010-10-01

... 46 Shipping 8 2010-10-01 2010-10-01 false When the NSA-WORKSMALREP Contract may be used. Sec. 3 Section 3 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY... REPAIRS-NSA-WORKSMALREP Sec. 3 When the NSA-WORKSMALREP Contract may be used. This contract may be used...

The 12 item Social and Economic Conservatism Scale (SECS.

Directory of Open Access Journals (Sweden)

Jim A C Everett

Full Text Available Recent years have seen a surge in psychological research on the relationship between political ideology (particularly conservatism and cognition, affect, behaviour, and even biology. Despite this flurry of investigation, however, there is as yet no accepted, validated, and widely used multi-item scale of conservatism that is concise, that is modern in its conceptualisation, and that includes both social and economic conservatism subscales. In this paper the 12-Item Social and Economic Conservatism Scale (SECS is proposed and validated to help fill this gap. The SECS is suggested to be an important and useful tool for researchers working in political psychology.

The bacterial Sec system is required for the organization and function of the MreB cytoskeleton.

Science.gov (United States)

Govindarajan, Sutharsan; Amster-Choder, Orna

2017-09-01

The Sec system is responsible for protein insertion, translocation and secretion across membranes in all cells. The bacterial actin homolog MreB controls various processes, including cell wall synthesis, membrane organization and polarity establishment. Here we show that the two systems genetically interact and that components of the Sec system, especially the SecA motor protein, are essential for spatiotemporal organization of MreB in E. coli, as evidenced by the accumulation of MreB at irregular sites in Sec-impaired cells. MreB mislocalization in SecA-defective cells significantly affects MreB-coordinated processes, such as cell wall synthesis, and induce formation of membrane invaginations enriched in high fluidity domains. Additionally, MreB is not recruited to the FtsZ ring in secA mutant cells, contributing to division arrest and cell filamentation. Our results show that all these faults are due to improper targeting of MreB to the membrane in the absence of SecA. Thus, when we reroute RodZ, MreB membrane-anchor, by fusing it to a SecA-independent integral membrane protein and overproducing it, MreB localization is restored and the defect in cell division is corrected. Notably, the RodZ moiety is not properly inserted into the membrane, strongly suggesting that it only serves as a bait for placing MreB around the cell circumference. Finally, we show that MreB localization depends on SecA also in C. crescentus, suggesting that regulation of MreB by the Sec system is conserved in bacteria. Taken together, our data reveal that the secretion system plays an important role in determining the organization and functioning of the cytoskeletal system in bacteria.

Roles of the conserved cytoplasmic region and non-conserved carboxy-terminal region of SecE in Escherichia coli protein translocase.

Science.gov (United States)

Kontinen, V P; Yamanaka, M; Nishiyama, K; Tokuda, H

1996-06-01

SecE, an essential membrane component of the Escherichia coli protein translocase, consists of 127 amino acid residues. Only a part of the second putative cytoplasmic region comprising some 13 residues is essential for the SecE function as long as the proper topological arrangement is retained. The Trp84 and Pro85 residues of this region are conserved in all eubacterial SecE homologues. The conservation of positively charged residues corresponding to Arg80 and Lys81 is also substantial. We deleted or replaced these residues to assess their roles in the SecE function. Deletion of the Arg80-Lys81 dipeptide did not abolish the SecE function whereas that of Trp84 or Pro85 caused a loss of the function. Strikingly, however, replacement of Pro85 with either Gly, Ser, or Ala, and that of Trp84 with Lys did not abolish the SecE function. These results indicate that the strong conservation of these residues does not reflect their obligatory requirement for the SecE function. A chimeric SecE possessing the cytoplasmic region of the E. coli SecE and the following region of the Bacillus subtilis SecE was able to form the translocation machinery together with SecA, SecY, and SecG. Although a Leu to Arg mutation at position 108 has been thought to cause a loss of signal recognition fidelity and thereby suppress a signal sequence defect, the same mutation at position 111 caused a complete loss of the function. The levels of SecY and SecG in the secEcsE501 mutant, which expresses SecE at a decreased level and is sensitive to low temperature, increased upon the expression of functional SecE derivatives, irrespective of the site of mutation, suggesting that the levels of SecY and SecG are co-operatively determined by the level of functional, but not non-functional, SecE. Based on these results, the SecE function in the translocase is discussed.

SecMAS: Security Enhanced Monitoring and Analysis Systems for Wireless Sensor Networks

Directory of Open Access Journals (Sweden)

Ding Chao

2016-01-01

Full Text Available The monitoring, control, and security guarantee for the communication in the wireless sensor networks (WSNs are currently treated as three independent issues and addressed separately through specialized tools. However, most cases of WSNs applications requires the network administrator change the network configuration in a very short time to response to the change of observed phenomenon with security guarantee. To meet this requirement, we propose a security enhanced monitoring and control platform named SecMAS for WSNs, which provides the real-time visualization about network states and online reconfiguration of the network properties and behaviours in a resource-efficient way. Besides, basic cryptographic primitives and part of the anomaly detection functionalities are implemented in SecMAS to enabling the secure communication in WSNs. Furthermore, we conduct experiments to evaluate the performance of SecMAS in terms of the latency, throughput, communication overhead, and the security capacity. The experimental results demonstrate that the SecMAS system achieves stable, efficient and secure data collection with lightweight quick-response network control.

SecA is required for membrane targeting of the cell division protein DivIVA in vivo

Directory of Open Access Journals (Sweden)

Sven eHalbedel

2014-02-01

Full Text Available The conserved protein DivIVA is involved in different morphogenetic processes in Gram-positive bacteria. In Bacillus subtilis, the protein localises to the cell division site and cell poles, and functions as a scaffold for proteins that regulate division site selection, and for proteins that are required for sporulation. To identify other proteins that bind to DivIVA, we performed an in vivo cross-linking experiment. A possible candidate that emerged was the secretion motor ATPase SecA. SecA mutants have been described that inhibit sporulation, and since DivIVA is necessary for sporulation, we examined the localisation of DivIVA in these mutants. Surprisingly, DivIVA was delocalised, suggesting that SecA is required for DivIVA targeting. To further corroborate this, we performed SecA depletion and inhibition experiments, which provided further indications that DivIVA localisation depends on SecA. Cell fractionation experiments showed that SecA is important for binding of DivIVA to the cell membrane. This was unexpected since DivIVA does not contain a signal sequence, and is able to bind to artificial lipid membranes in vitro without support of other proteins. SecA is required for protein secretion and membrane insertion, and therefore its role in DivIVA localisation is likely indirect. Possible alternative roles of SecA in DivIVA folding and/or targeting are discussed.

46 CFR Sec. 3 - Preparation of invoices.

Science.gov (United States)

2010-10-01

... NSA ORDER NO. 47 Sec. 3 Preparation of invoices. (a) Pursuant to Article 4 of the Service Agreement... under the applicable provisions of NSA Order No. 47. (1) Invoices shall be prepared so as to show... provisions of NSA Order No. 47 due the undersigned General Agent for the month of _____ under Service...

32 CFR 2400.15 - Classification guides.

Science.gov (United States)

2010-07-01

... REGULATIONS TO IMPLEMENT E.O. 12356; OFFICE OF SCIENCE AND TECHNOLOGY POLICY INFORMATION SECURITY PROGRAM Derivative Classification § 2400.15 Classification guides. (a) OSTP shall issue and maintain classification guides to facilitate the proper and uniform derivative classification of information. These guides shall...

Medicare program; revisions to payment policies under the Physician Fee Schedule, and other part B payment policies for CY 2008; delay of the date of applicability of the revised anti-markup provisions for certain services furnished in certain locations (Sec. 414.50). Final rule.

Science.gov (United States)

2008-01-03

This final rule delays until January 1, 2009 the applicability of the anti-markup provisions in Sec. 414.50, as revised at 72 FR 66222, except with respect to the technical component of a purchased diagnostic test and with respect to any anatomic pathology diagnostic testing services furnished in space that: Is utilized by a physician group practice as a "centralized building" (as defined at Sec. 411.351 of this chapter) for purposes of complying with the physician self-referral rules; and does not qualify as a "same building" under Sec. 411.355(b)(2)(i) of this chapter.

Microscopy analysis of reconstituted COPII coat polymerization and Sec16 dynamics.

Science.gov (United States)

Iwasaki, Hirohiko; Yorimitsu, Tomohiro; Sato, Ken

2017-09-01

The COPII coat and the small GTPase Sar1 mediate protein export from the endoplasmic reticulum (ER) via specialized domains known as the ER exit sites. The peripheral ER protein Sec16 has been proposed to organize ER exit sites. However, it remains unclear how these molecules drive COPII coat polymerization. Here, we characterized the spatiotemporal relationships between the Saccharomyces cerevisiae COPII components during their polymerization by performing fluorescence microscopy of an artificial planar membrane. We demonstrated that Sar1 dissociates from the membrane shortly after the COPII coat recruitment, and Sar1 is then no longer required for the COPII coat to bind to the membrane. Furthermore, we found that Sec16 is incorporated within the COPII-cargo clusters, and that this is dependent on the Sar1 GTPase cycle. These data show how Sar1 drives the polymerization of COPII coat and how Sec16 is spatially distributed during COPII coat polymerization. © 2017. Published by The Company of Biologists Ltd.

ODI launches RAPID Outcome Mapping Approach online guide ...

International Development Research Centre (IDRC) Digital Library (Canada)

17 juin 2014 ... The UK-based Overseas Development Institute has released its online guide to understanding, engaging with, and influencing policy. ROMA: A guide to policy engagement and influence contains a suite of tools that can be used to unpack complex problems, analyze stakeholder influence, and understand ...

46 CFR Sec. 2 - Submission of repair entries.

Science.gov (United States)

2010-10-01

... MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY GENERAL AGENT'S RESPONSIBILITY IN CONNECTION WITH FOREIGN REPAIR CUSTOM'S ENTRIES Sec. 2 Submission of repair entries. At the... with the District Director of Customs as defined in 19 CFR 1.1(d) an affidavit on Custom's Form 3417...

NPAS Users Guide

International Nuclear Information System (INIS)

1984-01-01

This NPAS Users Guide is primarily intended as a source of information about policies, procedures, and facilities appropriate for users in the program of Nuclear Physics at SLAC (NPAS). General policies and practices are described, the preparation of proposals is discussed, and the services for users is outlined. SLAC experimental facilities are described, and contacts are listed

Amblyomma americanum salivary gland homolog of nSec1 is essential for saliva protein secretion

International Nuclear Information System (INIS)

Karim, Shahid; Ramakrishnan, Vijay G.; Tucker, James S.; Essenberg, Richard C.; Sauer, John R.

2004-01-01

Soluble N-ethylmaleimide-sensitive factor attachment protein receptor proteins assemble in tight core complexes which promote fusion of carrier vesicles with target compartments. Members of this class of proteins are expressed in all eukaryotic cells and distributed in distinct subcellular compartments. All vesicle transport mechanisms known to date have an essential requirement for a member of the Sec1 protein family, including the nSec1 in regulated exocytosis. A homolog of nSec1 was cloned and sequenced from the salivary glands of partially fed female ticks. Double-stranded RNA was used to specifically reduce the amount of nSec1 mRNA and protein in female adult tick salivary glands. This reduction was accompanied by a decrease in anticoagulant protein release by the glands and by abnormalities in feeding by dsRNA treated ticks. We report the efficacy of double-stranded RNA-mediated interference in 'knocking down' nSec1 both in vivo and in vitro in tick salivary glands and the applicability of this technique for studying the mechanism of exocytosis in tick salivary glands

78 FR 69286 - Electric System Construction Policies and Procedures

Science.gov (United States)

2013-11-19

... DEPARTMENT OF AGRICULTURE Rural Utilities Service 7 CFR Part 1726 Electric System Construction Policies and Procedures CFR Correction In Title 7 of the Code of Federal Regulations, Parts 1600 to 1759, revised as of January 1, 2013, on page 246, in Sec. 1726.14, the second definition of Minor modification...

O-acetylation of the serine-rich repeat glycoprotein GspB is coordinated with accessory Sec transport.

Directory of Open Access Journals (Sweden)

Ravin Seepersaud

2017-08-01

Full Text Available The serine-rich repeat (SRR glycoproteins are a family of adhesins found in many Gram-positive bacteria. Expression of the SRR adhesins has been linked to virulence for a variety of infections, including streptococcal endocarditis. The SRR preproteins undergo intracellular glycosylation, followed by export via the accessory Sec (aSec system. This specialized transporter is comprised of SecA2, SecY2 and three to five accessory Sec proteins (Asps that are required for export. Although the post-translational modification and transport of the SRR adhesins have been viewed as distinct processes, we found that Asp2 of Streptococcus gordonii also has an important role in modifying the SRR adhesin GspB. Biochemical analysis and mass spectrometry indicate that Asp2 is an acetyltransferase that modifies N-acetylglucosamine (GlcNAc moieties on the SRR domains of GspB. Targeted mutations of the predicted Asp2 catalytic domain had no effect on transport, but abolished acetylation. Acetylated forms of GspB were only detected when the protein was exported via the aSec system, but not when transport was abolished by secA2 deletion. In addition, GspB variants rerouted to export via the canonical Sec pathway also lacked O-acetylation, demonstrating that this modification is specific to export via the aSec system. Streptococci expressing GspB lacking O-acetylated GlcNAc were significantly reduced in their ability bind to human platelets in vitro, an interaction that has been strongly linked to virulence in the setting of endocarditis. These results demonstrate that Asp2 is a bifunctional protein involved in both the post-translational modification and transport of SRR glycoproteins. In addition, these findings indicate that these processes are coordinated during the biogenesis of SRR glycoproteins, such that the adhesin is optimally modified for binding. This requirement for the coupling of modification and export may explain the co-evolution of the SRR

The coat protein complex II, COPII, protein Sec13 directly interacts with presenilin-1

International Nuclear Information System (INIS)

Nielsen, Anders Lade

2009-01-01

Mutations in the human gene encoding presenilin-1, PS1, account for most cases of early-onset familial Alzheimer's disease. PS1 has nine transmembrane domains and a large loop orientated towards the cytoplasm. PS1 locates to cellular compartments as endoplasmic reticulum (ER), Golgi apparatus, vesicular structures, and plasma membrane, and is an integral member of γ-secretase, a protein protease complex with specificity for intra-membranous cleavage of substrates such as β-amyloid precursor protein. Here, an interaction between PS1 and the Sec13 protein is described. Sec13 takes part in coat protein complex II, COPII, vesicular trafficking, nuclear pore function, and ER directed protein sequestering and degradation control. The interaction maps to the N-terminal part of the large hydrophilic PS1 loop and the first of the six WD40-repeats present in Sec13. The identified Sec13 interaction to PS1 is a new candidate interaction for linking PS1 to secretory and protein degrading vesicular circuits.

The coat protein complex II, COPII, protein Sec13 directly interacts with presenilin-1

Energy Technology Data Exchange (ETDEWEB)

Nielsen, Anders Lade, E-mail: aln@humgen.au.dk [Department of Human Genetics, The Bartholin Building, University of Aarhus, DK-8000 Aarhus C (Denmark)

2009-10-23

Mutations in the human gene encoding presenilin-1, PS1, account for most cases of early-onset familial Alzheimer's disease. PS1 has nine transmembrane domains and a large loop orientated towards the cytoplasm. PS1 locates to cellular compartments as endoplasmic reticulum (ER), Golgi apparatus, vesicular structures, and plasma membrane, and is an integral member of {gamma}-secretase, a protein protease complex with specificity for intra-membranous cleavage of substrates such as {beta}-amyloid precursor protein. Here, an interaction between PS1 and the Sec13 protein is described. Sec13 takes part in coat protein complex II, COPII, vesicular trafficking, nuclear pore function, and ER directed protein sequestering and degradation control. The interaction maps to the N-terminal part of the large hydrophilic PS1 loop and the first of the six WD40-repeats present in Sec13. The identified Sec13 interaction to PS1 is a new candidate interaction for linking PS1 to secretory and protein degrading vesicular circuits.

Happiness surveys: exclusive guides for policy?

OpenAIRE

Gunther Tichy

2014-01-01

Happiness is increasingly named as a target of policy measures. Apart from the confusing fact that the attention-grabbing catchword ‘happiness’ refers to ‘life satisfaction’ in most cases, this approach appears preferable to alternatives as utility functions, magic polygons or to the opaque decisions of politicians. A life-satisfaction-oriented policy would prove welfare-improving, focusing on fair distribution of income and wealth, social goals and institutional goals such as health,...

46 CFR Sec. 7 - Disbursements at foreign ports.

Science.gov (United States)

2010-10-01

...-agent shall pay invoices from such advances and shall make proper accounting to the agent for all... RULES FOR FINANCIAL TRANSACTIONS UNDER AGENCY AGREEMENTS Disbursements Sec. 7 Disbursements at foreign... or by any other method outlined to and approved by the owner in advance of its use: (a) The agent may...

46 CFR Sec. 4 - Persons authorized to make awards under the NSA-WORKSMALREP Contract.

Science.gov (United States)

2010-10-01

... 46 Shipping 8 2010-10-01 2010-10-01 false Persons authorized to make awards under the NSA-WORKSMALREP Contract. Sec. 4 Section 4 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A... INDIVIDUAL CONTRACT FOR MINOR REPAIRS-NSA-WORKSMALREP Sec. 4 Persons authorized to make awards under the NSA...

Collegiate Drug Management Guide.

Science.gov (United States)

Janosik, Steven M.; Anderson, David S.

A checklist to help colleges and universities reevaluate their policies and procedures regarding drug use among college students is presented. It is designed to supplement the "Collegiate Alcohol Risk Assessment Guide." In this guide drugs other than alcohol are of concern, although alcohol is viewed by many as the "drug of choice" among college…

Functional Analysis of Developmentally Regulated Genes chs7 and sec22 in the Ascomycete Sordaria macrospora.

Science.gov (United States)

Traeger, Stefanie; Nowrousian, Minou

2015-04-14

During sexual development, filamentous ascomycetes form complex, three-dimensional fruiting bodies for the generation and dispersal of spores. In previous studies, we identified genes with evolutionary conserved expression patterns during fruiting body formation in several fungal species. Here, we present the functional analysis of two developmentally up-regulated genes, chs7 and sec22, in the ascomycete Sordaria macrospora. The genes encode a class VII (division III) chitin synthase and a soluble N-ethylmaleimide-sensitive-factor attachment protein receptor (SNARE) protein, respectively. Deletion mutants of chs7 had normal vegetative growth and were fully fertile but showed sensitivity toward cell wall stress. Deletion of sec22 resulted in a reduced number of ascospores and in defects in ascospore pigmentation and germination, whereas vegetative growth was normal in the mutant. A SEC22-EGFP fusion construct under control of the native sec22 promoter and terminator regions was expressed during different stages of sexual development. Expression of several development-related genes was deregulated in the sec22 mutant, including three genes involved in melanin biosynthesis. Our data indicate that chs7 is dispensable for fruiting body formation in S. macrospora, whereas sec22 is required for ascospore maturation and germination and thus involved in late stages of sexual development. Copyright © 2015 Traeger and Nowrousian.

46 CFR Sec. 8 - Extra work and changes.

Science.gov (United States)

2010-10-01

... Contractor may appeal such contract price or revised completion date as provided in Article 27 of the NSA... 46 Shipping 8 2010-10-01 2010-10-01 false Extra work and changes. Sec. 8 Section 8 Shipping... ACCOMPLISHMENT OF VESSEL REPAIRS UNDER NATIONAL SHIPPING AUTHORITY MASTER LUMP SUM REPAIR CONTRACT-NSA-LUMPSUMREP...

Sec16 in conventional and unconventional exocytosis: Working at the interface of membrane traffic and secretory autophagy?

Science.gov (United States)

Tang, Bor Luen

2017-12-01

Sec16 is classically perceived to be a scaffolding protein localized to the transitional endoplasmic reticulum (tER) or the ER exit sites (ERES), and has a conserved function in facilitating coat protein II (COPII) complex-mediated ER exit. Recent findings have, however, pointed toward a role for Sec16 in unconventional exocytosis of certain membrane proteins, such as the Cystic fibrosis transmembrane conductance regulator (CFTR) in mammalian cells, and possibly also α-integrin in certain contexts of Drosophila development. In this regard, Sec16 interacts with components of a recently deciphered pathway of stress-induced unconventional exocytosis, which is dependent on the tether protein Golgi reassembly stacking proteins (GRASPs) and the autophagy pathway. Intriguingly, Sec16 also appears to be post-translationally modified by autophagy-related signaling processes. Sec16 is known to be phosphorylated by the atypical extracellular signal regulated kinase 7 (Erk7) upon serum and amino acid starvation, both represent conditions that trigger autophagy. Recent work has also shown that Sec16 is phosphorylated, and thus regulated by the prominent autophagy-initiating Unc-51-like autophagy activating kinase 1 (Ulk1), as well as another autophagy modulator Leucine-rich repeat kinase 2 (Lrrk2). The picture emerging from Sec16's network of physical and functional interactors allows the speculation that Sec16 is situated (and may in yet undefined ways function) at the interface between COPII-mediated exocytosis of conventional vesicular traffic and the GRASP/autophagy-dependent mode of unconventional exocytosis. © 2017 Wiley Periodicals, Inc.

Institutional investors' reaction to SEC concerns about IFRS and US GAAP reporting

OpenAIRE

Miles, Gietzmann; Helena, Isidro

2013-01-01

For the period of 2006 to 2008, we collect Comment Letters issued by the SEC that question the application of US GAAP by US firms or the application of IFRS by European firms registered with the SEC. We investigate whether institutional investors react to the letters by changing their holdings and whether their responses vary for US registrants and European registrants. We do this via a treatment-effects model in which we test the hypothesis that institutional investors rebalance their portfo...

Apoptosis-linked Gene-2 (ALG-2)/Sec31 Interactions Regulate Endoplasmic Reticulum (ER)-to-Golgi Transport

Science.gov (United States)

Helm, Jared R.; Bentley, Marvin; Thorsen, Kevin D.; Wang, Ting; Foltz, Lauren; Oorschot, Viola; Klumperman, Judith; Hay, Jesse C.

2014-01-01

Luminal calcium released from secretory organelles has been suggested to play a regulatory role in vesicle transport at several steps in the secretory pathway; however, its functional roles and effector pathways have not been elucidated. Here we demonstrate for the first time that specific luminal calcium depletion leads to a significant decrease in endoplasmic reticulum (ER)-to-Golgi transport rates in intact cells. Ultrastructural analysis revealed that luminal calcium depletion is accompanied by increased accumulation of intermediate compartment proteins in COPII buds and clusters of unfused COPII vesicles at ER exit sites. Furthermore, we present several lines of evidence suggesting that luminal calcium affected transport at least in part through calcium-dependent interactions between apoptosis-linked gene-2 (ALG-2) and the Sec31A proline-rich region: 1) targeted disruption of ALG-2/Sec31A interactions caused severe defects in ER-to-Golgi transport in intact cells; 2) effects of luminal calcium and ALG-2/Sec31A interactions on transport mutually required each other; and 3) Sec31A function in transport required luminal calcium. Morphological phenotypes of disrupted ALG-2/Sec31A interactions were characterized. We found that ALG-2/Sec31A interactions were not required for the localization of Sec31A to ER exit sites per se but appeared to acutely regulate the stability and trafficking of the cargo receptor p24 and the distribution of the vesicle tether protein p115. These results represent the first outline of a mechanism that connects luminal calcium to specific protein interactions regulating vesicle trafficking machinery. PMID:25006245

A Good Practice Guide on Critical Infor-mation Infrastructure Protection

NARCIS (Netherlands)

Luiijf, H.A.M.; Schie, T.C.C. van

2017-01-01

Early 2016, the Meridian Process and the GFCE tasked the Netherlands Organisation for Applied Scientific Research TNO to develop a Good Practice Guide on Critical Information Infrastructure Protection (CIIP) for governmental policy-makers [1]. The guide primarily aims at governmental policy-makers,

The Policy Delphi: A Method for Identifying Intended and Unintended Consequences of Educational Policy

Science.gov (United States)

Manley, R. Adam

2013-01-01

This article highlights a rarely utilized but effective technique for identifying intended and unintended consequences of past or current policy or policy change. The author guides the reader through the process of identifying potential participants, contacting participants, developing the policy Delphi instrument, and analyzing the findings by…

Guide Actor-Critic for Continuous Control

OpenAIRE

Tangkaratt, Voot; Abdolmaleki, Abbas; Sugiyama, Masashi

2017-01-01

Actor-critic methods solve reinforcement learning problems by updating a parameterized policy known as an actor in a direction that increases an estimate of the expected return known as a critic. However, existing actor-critic methods only use values or gradients of the critic to update the policy parameter. In this paper, we propose a novel actor-critic method called the guide actor-critic (GAC). GAC firstly learns a guide actor that locally maximizes the critic and then it updates the polic...

Inactivation of protein translocation by cold-sensitive mutations in the yajC-secDF operon

NARCIS (Netherlands)

Nouwen, N; Driessen, AJM

2005-01-01

Most mutations in the yajC-secDF operon identified via genetic screens confer a cold-sensitive growth phenotype. Here we report that two of these mutations confer this cold-sensitive phenotype by inactivating the SecDF-YajC complex in protein translocation.

Phospho-Rasputin Stabilization by Sec16 Is Required for Stress Granule Formation upon Amino Acid Starvation

Directory of Open Access Journals (Sweden)

Angelica Aguilera-Gomez

2017-07-01

Full Text Available Most cellular stresses induce protein translation inhibition and stress granule formation. Here, using Drosophila S2 cells, we investigate the role of G3BP/Rasputin in this process. In contrast to arsenite treatment, where dephosphorylated Ser142 Rasputin is recruited to stress granules, we find that, upon amino acid starvation, only the phosphorylated Ser142 form is recruited. Furthermore, we identify Sec16, a component of the endoplasmic reticulum exit site, as a Rasputin interactor and stabilizer. Sec16 depletion results in Rasputin degradation and inhibition of stress granule formation. However, in the absence of Sec16, pharmacological stabilization of Rasputin is not enough to rescue the assembly of stress granules. This is because Sec16 specifically interacts with phosphorylated Ser142 Rasputin, the form required for stress granule formation upon amino acid starvation. Taken together, these results demonstrate that stress granule formation is fine-tuned by specific signaling cues that are unique to each stress. These results also expand the role of Sec16 as a stress response protein.

High-Resolution Genetics Identifies the Lipid Transfer Protein Sec14p as Target for Antifungal Ergolines.

Directory of Open Access Journals (Sweden)

Ireos Filipuzzi

2016-11-01

Full Text Available Invasive infections by fungal pathogens cause more deaths than malaria worldwide. We found the ergoline compound NGx04 in an antifungal screen, with selectivity over mammalian cells. High-resolution chemogenomics identified the lipid transfer protein Sec14p as the target of NGx04 and compound-resistant mutations in Sec14p define compound-target interactions in the substrate binding pocket of the protein. Beyond its essential lipid transfer function in a variety of pathogenic fungi, Sec14p is also involved in secretion of virulence determinants essential for the pathogenicity of fungi such as Cryptococcus neoformans, making Sec14p an attractive antifungal target. Consistent with this dual function, we demonstrate that NGx04 inhibits the growth of two clinical isolates of C. neoformans and that NGx04-related compounds have equal and even higher potency against C. neoformans. Furthermore NGx04 analogues showed fungicidal activity against a fluconazole resistant C. neoformans strain. In summary, we present genetic evidence that NGx04 inhibits fungal Sec14p and initial data supporting NGx04 as a novel antifungal starting point.

Mechanism of conformational coupling in SecA: Key role of hydrogen-bonding networks and water interactions.

Science.gov (United States)

Milenkovic, Stefan; Bondar, Ana-Nicoleta

2016-02-01

SecA uses the energy yielded by the binding and hydrolysis of adenosine triphosphate (ATP) to push secretory pre-proteins across the plasma membrane in bacteria. Hydrolysis of ATP occurs at the nucleotide-binding site, which contains the conserved carboxylate groups of the DEAD-box helicases. Although crystal structures provide valuable snapshots of SecA along its reaction cycle, the mechanism that ensures conformational coupling between the nucleotide-binding site and the other domains of SecA remains unclear. The observation that SecA contains numerous hydrogen-bonding groups raises important questions about the role of hydrogen-bonding networks and hydrogen-bond dynamics in long-distance conformational couplings. To address these questions, we explored the molecular dynamics of SecA from three different organisms, with and without bound nucleotide, in water. By computing two-dimensional hydrogen-bonding maps we identify networks of hydrogen bonds that connect the nucleotide-binding site to remote regions of the protein, and sites in the protein that respond to specific perturbations. We find that the nucleotide-binding site of ADP-bound SecA has a preferred geometry whereby the first two carboxylates of the DEAD motif bridge via hydrogen-bonding water. Simulations of a mutant with perturbed ATP hydrolysis highlight the water-bridged geometry as a key structural element of the reaction path. Copyright © 2015. Published by Elsevier B.V.

Evolutionary conservation of dual Sec translocases in the cyanelles of Cyanophora paradoxa

Directory of Open Access Journals (Sweden)

Löffelhardt Wolfgang

2008-11-01

Full Text Available Abstract Background Cyanelles, the peptidoglycan-armored plastids of glaucocystophytes, occupy a unique bridge position in between free-living cyanobacteria and chloroplasts. In some respects they side with cyanobacteria whereas other features are clearly shared with chloroplasts. The Sec translocase, an example for "conservative sorting" in the course of evolution, is found in the plasma membrane of all prokaryotes, in the thylakoid membrane of chloroplasts and in both these membrane types of cyanobacteria. Results In this paper we present evidence for a dual location of the Sec translocon in the thylakoid as well as inner envelope membranes of the cyanelles from Cyanophora paradoxa, i. e. conservative sorting sensu stricto. The prerequisite was the generation of specific antisera directed against cyanelle SecY that allowed immunodetection of the protein on SDS gels from both membrane types separated by sucrose density gradient floatation centrifugation. Immunoblotting of blue-native gels yielded positive but differential results for both the thylakoid and envelope Sec complexes, respectively. In addition, heterologous antisera directed against components of the Toc/Tic translocons and binding of a labeled precursor protein were used to discriminate between inner and outer envelope membranes. Conclusion The envelope translocase can be envisaged as a prokaryotic feature missing in higher plant chloroplasts but retained in cyanelles, likely for protein transport to the periplasm. Candidate passengers are cytochrome c6 and enzymes of peptidoglycan metabolism. The minimal set of subunits of the Toc/Tic translocase of a primitive plastid is proposed.

14 CFR Sec. 2-1 - Generally accepted accounting principles.

Science.gov (United States)

2010-01-01

...). Persons subject to this part are authorized to implement, as prescribed by the Financial Accounting... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Generally accepted accounting principles... AIR CARRIERS General Accounting Provisions Sec. 2-1 Generally accepted accounting principles. (a) The...

46 CFR Sec. 3 - Application for remission of duties.

Science.gov (United States)

2010-10-01

... Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY GENERAL AGENT'S RESPONSIBILITY IN CONNECTION WITH FOREIGN REPAIR CUSTOM'S ENTRIES Sec. 3 Application for remission... District Director of Customs as defined in 19 CFR 1.1(d) if the following circumstances prevail: (a) When...

46 CFR Sec. 5 - Procedure for negotiated price awards.

Science.gov (United States)

2010-10-01

... shall be furnished with the information provided for in Article 1(a) of the NSA-LUMPSUMREP Contract. (b... Article 27 of the NSA-LUMPSUMREP Contract. ... 46 Shipping 8 2010-10-01 2010-10-01 false Procedure for negotiated price awards. Sec. 5 Section 5...

Identification and characterization of a novel protective antigen, Sec_205 of Streptococcus equi ssp. Zooepidemicus.

Science.gov (United States)

Liang, Huihuang; Tang, Bin; Zhao, Pengpeng; Deng, Mingyong; Yan, Lili; Zhai, Pan; Wei, Zigong

2018-02-01

Streptococcus equi ssp. zooepidemicus (SEZ) is an important pathogen of swine streptococcal diseases and can infect a wide range of animals as well as human beings. The absence of effective vaccine confounds the control of SEZ infection. Sec_205, a novel protein identified in the previous study, was inducibly over-expressed in Escherichia coli in the present study. The purified recombinant protein could elicit a significant humoral antibody response and provide efficient protection against lethal challenge of SEZ C55138 in mouse model. The protection against SEZ infection was mediated by specific antibodies to Sec_205 to some extent and was identified by the passive protection assay. The Sec_205 was an in vivo-induced antigen confirmed by the real-time PCR and could adhere to the Hep-2 cells by the inhibition assay. These suggest that Sec_205 may play a vital role in pathogenicity and serve as a new vaccine candidate against SEZ infection. Copyright © 2018 Elsevier Ltd. All rights reserved.

Identification of SEC62 as a potential marker for 3q amplification and cellular migration in dysplastic cervical lesions

International Nuclear Information System (INIS)

Linxweiler, Maximilian; Bochen, Florian; Schick, Bernhard; Wemmert, Silke; Al Kadah, Basel; Greiner, Markus; Hasenfus, Andrea; Bohle, Rainer-Maria; Juhasz-Böss, Ingolf; Solomayer, Erich-Franz; Takacs, Zoltan Ferenc

2016-01-01

Chromosome 3 amplification affecting the 3q26 region is a common genomic alteration in cervical cancer, typically marking the transition of precancerous intraepithelial lesions to an invasive phenotype. Though potential 3q encoded target genes of this amplification have been identified, a functional correlation of potential oncogenic function is still missing. In this study, we investigated copy number changes and the expression level of SEC62 encoded at 3q26.2 as a new potential 3q oncogene in dysplastic cervical lesions and analyzed its role in cervical cancer cell biology. Expression levels of Sec62 and vimentin were analyzed in liquid based cytology specimens from 107 women with varying grades of cervical dysplasia ranging from normal cases to cancer by immunofluorescence cytology. Additionally, a subset of 20 representative cases was used for FISH analyses targeting SEC62. To further explore the functional role of Sec62 in cervical cancer, HeLa cells were transfected with a SEC62 plasmid or SEC62 siRNA and analyzed for their proliferation and migration potential using real-time monitoring and trans-well systems as well as changes in the expression of EMT markers. FISH analyses of the swabbed cells showed a rising number of SEC62 gains and amplifications correlating to the grade of dysplasia with the highest incidence in high grade squamous intraepithelial lesions and squamous cell carcinomas. When analyzing the expression level of Sec62 and vimentin, we found a gradually increasing expression level of both proteins according to the severity of the dysplasia. In functional analyses, SEC62 silencing inhibited and SEC62 overexpression stimulated the migration of HeLa cells with only marginal effects on cell proliferation, the expression level of EMT markers and the cytoskeleton structure. Our study suggests SEC62 as a target gene of 3q26 amplification and a stimulator of cellular migration in dysplastic cervical lesions. Hence, SEC62 could serve as a potential

Charter School Replication. Policy Guide

Science.gov (United States)

Rhim, Lauren Morando

2009-01-01

"Replication" is the practice of a single charter school board or management organization opening several more schools that are each based on the same school model. The most rapid strategy to increase the number of new high-quality charter schools available to children is to encourage the replication of existing quality schools. This policy guide…

Policy Innovation in Innovation Policy

DEFF Research Database (Denmark)

Borras, Susana

During the past two decades Europe has experienced important changes and transformations in the way in which governments approach the issue of science, technology and innovation, and their relation to economic growth and competitiveness. This has to do with the European Union level as well...... as with national and sub-national governments in Europe, all of them introducing interesting novelties in their innovation policy. These changes refer to different aspects of policy, mainly the content of policy initiatives towards science, technology and innovation; the instruments governments are using...... at the EU level, and mentions similar trends taking place at national and sub-national levels. The questions that guide the contents here are essentially three, namely, what are the main traits of innovation policies in Europe since the 1990s and how have the EU and different national governments approached...

Fission yeast Sec3 and Exo70 are transported on actin cables and localize the exocyst complex to cell poles.

Directory of Open Access Journals (Sweden)

Felipe O Bendezú

Full Text Available The exocyst complex is essential for many exocytic events, by tethering vesicles at the plasma membrane for fusion. In fission yeast, polarized exocytosis for growth relies on the combined action of the exocyst at cell poles and myosin-driven transport along actin cables. We report here the identification of fission yeast Schizosaccharomyces pombe Sec3 protein, which we identified through sequence homology of its PH-like domain. Like other exocyst subunits, sec3 is required for secretion and cell division. Cells deleted for sec3 are only conditionally lethal and can proliferate when osmotically stabilized. Sec3 is redundant with Exo70 for viability and for the localization of other exocyst subunits, suggesting these components act as exocyst tethers at the plasma membrane. Consistently, Sec3 localizes to zones of growth independently of other exocyst subunits but depends on PIP(2 and functional Cdc42. FRAP analysis shows that Sec3, like all other exocyst subunits, localizes to cell poles largely independently of the actin cytoskeleton. However, we show that Sec3, Exo70 and Sec5 are transported by the myosin V Myo52 along actin cables. These data suggest that the exocyst holocomplex, including Sec3 and Exo70, is present on exocytic vesicles, which can reach cell poles by either myosin-driven transport or random walk.

Phospho-Rasputin Stabilization by Sec16 Is Required for Stress Granule Formation upon Amino Acid Starvation.

Science.gov (United States)

Aguilera-Gomez, Angelica; Zacharogianni, Margarita; van Oorschot, Marinke M; Genau, Heide; Grond, Rianne; Veenendaal, Tineke; Sinsimer, Kristina S; Gavis, Elizabeth R; Behrends, Christian; Rabouille, Catherine

2017-07-25

Most cellular stresses induce protein translation inhibition and stress granule formation. Here, using Drosophila S2 cells, we investigate the role of G3BP/Rasputin in this process. In contrast to arsenite treatment, where dephosphorylated Ser142 Rasputin is recruited to stress granules, we find that, upon amino acid starvation, only the phosphorylated Ser142 form is recruited. Furthermore, we identify Sec16, a component of the endoplasmic reticulum exit site, as a Rasputin interactor and stabilizer. Sec16 depletion results in Rasputin degradation and inhibition of stress granule formation. However, in the absence of Sec16, pharmacological stabilization of Rasputin is not enough to rescue the assembly of stress granules. This is because Sec16 specifically interacts with phosphorylated Ser142 Rasputin, the form required for stress granule formation upon amino acid starvation. Taken together, these results demonstrate that stress granule formation is fine-tuned by specific signaling cues that are unique to each stress. These results also expand the role of Sec16 as a stress response protein. Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved.

Group Policy Fundamentals, Security, and the Managed Desktop

CERN Document Server

Moskowitz, Jeremy

2010-01-01

The ultimate Group Policy guide-now updated for Windows 7 and Server 2008 R2!. IT and network administrators can streamline their Windows Server management tasks by using Group Policy tools to automate or implement rules, processes, or new security across the enterprise. In this comprehensive guide, Microsoft Group Policy MVP Jeremy Moskowitz thoroughly explores Group Policy across all Windows platforms, including the latest on Windows 7 and Server 2008 R2. If you're a Windows network administrator managing scores of users and computers, you need this essential reference on your desk.: Covers

46 CFR Sec. 6 - Disbursements at other domestic ports.

Science.gov (United States)

2010-10-01

... invoices from such advances and make proper accounting to the agent for each advance supported by invoices... RULES FOR FINANCIAL TRANSACTIONS UNDER AGENCY AGREEMENTS Disbursements Sec. 6 Disbursements at other... agent may advance from time to time from the joint bank account the funds necessary to meet the...

Users guide for the ANL IBM SPx

Energy Technology Data Exchange (ETDEWEB)

Gropp, W.; Lusk, E.

1994-12-01

This guide presents the features of the IBM SPx installed in the Mathematics and Computer Science Division at Argonne National Laboratory. The guide describes the available hardware and software, access policies, and hints for using the system productively.

The Impact of Visual Guided Order Picking on Ocular Comfort, Ocular Surface and Tear Function.

Directory of Open Access Journals (Sweden)

Angelika Klein-Theyer

Full Text Available We investigated the effects of a visual picking system on ocular comfort, the ocular surface and tear function compared to those of a voice guided picking solution.Prospective, observational, cohort study.Institutional.A total of 25 young asymptomatic volunteers performed commissioning over 10 hours on two consecutive days.The operators were guided in the picking process by two different picking solutions, either visually or by voice while their subjective symptoms and ocular surface and tear function parameters were recorded.The visual analogue scale (VAS values, according to subjective dry eye symptoms, in the visual condition were significantly higher at the end of the commissioning than the baseline measurements. In the voice condition, the VAS values remained stable during the commissioning. The tear break-up time (BUT values declined significantly in the visual condition (pre-task: 16.6 sec and post-task: 9.6 sec in the right eyes, that were exposed to the displays, the left eyes in the visual condition showed only a minor decline, whereas the BUT values in the voice condition remained constant (right eyes or even increased (left eyes over the time. No significant differences in the tear meniscus height values before and after the commissioning were observed in either condition.In our study, the use of visually guided picking solutions was correlated with post-task subjective symptoms and tear film instability.

National Environmental Policy Act source guide for the Hanford Site

International Nuclear Information System (INIS)

Jansky, M.T.

1998-01-01

This Source Guide will assist those working with the National Environmental Policy Act (NEPA) of 1969 to become more familiar with the environmental assessments (EA) and environmental impact statements (EIS) that apply to specific activities and facilities on the Hanford Site. This document should help answer questions concerning NEPA coverage, history, processes, and the status of many of the buildings and units on and related to the Hanford Site. This document summarizes relevant EAs and EISs by briefly outlining the proposed action of each document and the decision made by the US Department of Energy (DOE) or its predecessor agencies, the US Atomic Energy Commission (AEC) and the US Energy Research and Development Administration (ERDA). The summary includes the proposed action alternatives and current status of the proposed action. If a decision officially was stated by the DOE, as in a finding of no significant impact (FONSI) or a record of decision (ROD), and the decision was located, a summary is provided. Not all federal decisions, such as FONSIs and RODS, can be found in the Federal Register (FR). For example, although significant large-action FONSIs can be found in the FR, some low-interest FONSIs might have been published elsewhere (i.e., local newspapers)

Hydrophilic polymer-coated microcatheter-guide wire system for superselective angiographic procedures

International Nuclear Information System (INIS)

Kobayashi, Hisashi; Hiraki, Yoshiyuki; Nishimoto, Hidetou; Miyazono, Nobuaki; Satake, Mitsuo; Shinohara, Shinji

1988-01-01

A hydrophilic polymer-coated microcatheter-guide wire device has been newly developed for superselective angiography and interventional procedures. The injection rate of this microcatheter was estimated at 2.0 ml/sec. on the maximum pressure of 300 psi when used a non-ionic low osmolar contrast medium, Iopamidol 300. In two of three cases this catheter could make easy insertion into the peripheral branches of the right hepatic artery which were approximately 1 mm in vascular diameter. (author)

78 FR 53774 - Guide for the Evaluation of Alert and Notification Systems for Nuclear Power Plants, FEMA-REP-10...

Science.gov (United States)

2013-08-30

... available when FEMA REP-10 was first developed, such as smartphones and social media. Removes technical... proposed policy does not have the force or effect of law. FEMA seeks comment on the proposed policy, which... the force or effect of law. Authority: 6 U.S.C. 313-314a; Sec. 109, Pub. L. 96-295; E.O. 12148; 44 CFR...

75 FR 80826 - Compliance Policy Guide Sec. 527.300 Dairy Products-Microbial Contaminants and Alkaline...

Science.gov (United States)

2010-12-23

... Lane, Rockville, MD 20857. Send two self-addressed adhesive labels to assist that office in processing... Fishers Lane, Rm. 1061, Rockville, MD 20852. FOR FURTHER INFORMATION CONTACT: Monica Metz, Center for Food...

Guiding Warfare to Reach Sustainable Peace

DEFF Research Database (Denmark)

Vestenskov, David; Drewes, Line

The conference report Guiding Warfare to Reach Sustainable Peace constitutes the primary outcome of the conference It is based on excerpts from the conference presenters and workshop discussions. Furthermore, the report contains policy recommendations and key findings, with the ambition of develo......The conference report Guiding Warfare to Reach Sustainable Peace constitutes the primary outcome of the conference It is based on excerpts from the conference presenters and workshop discussions. Furthermore, the report contains policy recommendations and key findings, with the ambition...... of developing best practices in the education and implementation of IHL in capacity building of security forces....

17 CFR 200.80b - Appendix B-SEC releases.

Science.gov (United States)

2010-04-01

...; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Information and Requests § 200.80b Appendix B—SEC... purchased through the Superintendent of Documents as described in § 200.80c of this part. The Statistical... purchase through the Superintendent of Documents. [40 FR 1009, Jan. 6, 1975, as amended at 49 FR 12686, Mar...

SELinux policy administration

CERN Document Server

Vermeulen, Sven

2013-01-01

A step-by-step guide to learn how to set up security on Linux servers by taking SELinux policies into your own hands.Linux administrators will enjoy the various SELinux features that this book covers and the approach used to guide the admin into understanding how SELinux works. The book assumes that you have basic knowledge in Linux administration, especially Linux permission and user management.

Education Policy Influence Efficacy: Teacher Beliefs in Their Ability to Change Education Policy

Science.gov (United States)

Hinnant-Crawford, Brandi

2016-01-01

Guided by Social Cognitive Theory (SCT) this study sought to understand how teachers view themselves as educational policy actors and to construct an instrument that measures teacher beliefs about their aptitude to advocate for changes in educational policy. This study employed a sequential explanatory design, characterized by quantitative data…

Geology of Crownpoint Sec. 29 uranium deposit, McKinley County

International Nuclear Information System (INIS)

Wentworth, D.W.; Porter, D.A.; Jensen, H.N.

1980-01-01

The Crownpoint Sec. 29 deposit, located in the west-central part of the Grants mineral belt, represents a relatively recent uranium discovery in the Westwater Canyon Member (Jurassic) of the Morrison Formation. This deposit, estimated as containing up to 10 million pounds of uranium oxide, occurs in four vertically separate sandstone units. The average depth of the ore mineralization is approximately 2,000 ft (610 m) below the ground surface. Present-day structure of the Crownpoint Sec. 29 area is relatively simple and consists of gentle north-northeast-dipping strata with no known faulting. This deposit is located in an east-southeast-trending Westwater Canyon depocenter, whose course is believed to have been influenced by subtle Jurassic structure, which was penecontemporaneous with sedimentation. The deposit has been delineated by drilling on 200-ft (60-m) centers, involving approximately 348 holes and is awaiting shaft sinking and mine development

Creating Adaptive Policies: A Guide for Policy-making in an ...

International Development Research Centre (IDRC) Digital Library (Canada)

2009-01-01

Jan 1, 2009 ... This is an essential toolkit for those in the business of making, recommending, ... Policies that cannot perform effectively under today's complex, dynamic, and ... Suruchi Bhadwal is an Area Convener of the Centre for Global ...

Experiments of 10 Gbit/sec quantum stream cipher applicable to optical Ethernet and optical satellite link

Science.gov (United States)

Hirota, Osamu; Ohhata, Kenichi; Honda, Makoto; Akutsu, Shigeto; Doi, Yoshifumi; Harasawa, Katsuyoshi; Yamashita, Kiichi

2009-08-01

The security issue for the next generation optical network which realizes Cloud Computing System Service with data center" is urgent problem. In such a network, the encryption by physical layer which provide super security and small delay should be employed. It must provide, however, very high speed encryption because the basic link is operated at 2.5 Gbit/sec or 10 Gbit/sec. The quantum stream cipher by Yuen-2000 protocol (Y-00) is a completely new type random cipher so called Gauss-Yuen random cipher, which can break the Shannon limit for the symmetric key cipher. We develop such a cipher which has good balance of the security, speed and cost performance. In SPIE conference on quantum communication and quantum imaging V, we reported a demonstration of 2.5 Gbit/sec system for the commercial link and proposed how to improve it to 10 Gbit/sec. This paper reports a demonstration of the Y-00 cipher system which works at 10 Gbit/sec. A transmission test in a laboratory is tried to get the basic data on what parameters are important to operate in the real commercial networks. In addition, we give some theoretical results on the security. It is clarified that the necessary condition to break the Shannon limit requires indeed the quantum phenomenon, and that the full information theoretically secure system is available in the satellite link application.

Boolean and advanced searching for EDGAR data on www.sec.gov

Data.gov (United States)

Securities and Exchange Commission — This search allows users to enter complex boolean queries to access all but the most recent day's EDGAR filings on www.sec.gov. Filings are from 1994 to present.

Environmental Education Policy Development in Zimbabwe: An ...

African Journals Online (AJOL)

National environmental education policy is essential for guiding and coordinating environmental education activities within a country. The Zimbabwean Environmental Education Policy development process took place between 2000 and 2001.This paper looks at stages in the policy development process, the factors that ...

SEC16 in COPII coat dynamics at ER exit sites

NARCIS (Netherlands)

Sprangers, Joep; Rabouille, Catherine

Protein export from the endoplasmic reticulum (ER), the first step in protein transport through the secretory pathway, is mediated by coatomer protein II (COPII)-coated vesicles at ER exit sites. COPII coat assembly on the ER is well understood and the conserved large hydrophilic protein Sec16

The thermal degradation of poly(iso-butyl methacrylate and poly(sec-butyl methacrylate

Directory of Open Access Journals (Sweden)

IVANKA G. POPOVIC

2000-12-01

Full Text Available The non-oxidative thermal degradation of poly(iso-butyl methacrylate and poly(sec-butyl methacrylate was investigated by studying changes in the polymer residue. Due to the different number of b-hydrogens in their ester substituents, these two polymeric isomers behave differently when subjected to elevated temperatures. Poly(iso-butyl methacrylate degrades quantitatively by depolymerisation with zip lengths of the same order of magnitude as those of poly(methyl methacrylate. Poly(sec-butyl methacrylate degrades by a combined degradation mechanism of depolymerisation and de-esterification. De-esterification becomes a significant thermolysis route at temperatures higher than 240°C.

A User Guide for Smoothing Air Traffic Radar Data

Science.gov (United States)

Bach, Ralph E.; Paielli, Russell A.

2014-01-01

Matlab software was written to provide smoothing of radar tracking data to simulate ADS-B (Automatic Dependent Surveillance-Broadcast) data in order to test a tactical conflict probe. The probe, called TSAFE (Tactical Separation-Assured Flight Environment), is designed to handle air-traffic conflicts left undetected or unresolved when loss-of-separation is predicted to occur within approximately two minutes. The data stream that is down-linked from an aircraft equipped with an ADS-B system would include accurate GPS-derived position and velocity information at sample rates of 1 Hz. Nation-wide ADS-B equipage (mandated by 2020) should improve surveillance accuracy and TSAFE performance. Currently, position data are provided by Center radar (nominal 12-sec samples) and Terminal radar (nominal 4.8-sec samples). Aircraft ground speed and ground track are estimated using real-time filtering, causing lags up to 60 sec, compromising performance of a tactical resolution tool. Offline smoothing of radar data reduces wild-point errors, provides a sample rate as high as 1 Hz, and yields more accurate and lag-free estimates of ground speed, ground track, and climb rate. Until full ADS-B implementation is available, smoothed radar data should provide reasonable track estimates for testing TSAFE in an ADS-B-like environment. An example illustrates the smoothing of radar data and shows a comparison of smoothed-radar and ADS-B tracking. This document is intended to serve as a guide for using the smoothing software.

Evidence for informing health policy development in Low-income Countries (LICs): perspectives of policy actors in Uganda.

Science.gov (United States)

Nabyonga-Orem, Juliet; Mijumbi, Rhona

2015-03-08

Although there is a general agreement on the benefits of evidence informed health policy development given resource constraints especially in Low-Income Countries (LICs), the definition of what evidence is, and what evidence is suitable to guide decision-making is still unclear. Our study is contributing to filling this knowledge gap. We aimed to explore health policy actors' views regarding what evidence they deemed appropriate to guide health policy development. Using exploratory qualitative methods, we conducted interviews with 51 key informants using an in-depth interview guide. We interviewed a diverse group of stakeholders in health policy development and knowledge translation in the Uganda health sector. Data were analyzed using inductive content analysis techniques. Different stakeholders lay emphasis on different kinds of evidence. While donors preferred international evidence and Ministry of Health (MoH) officials looked to local evidence, district health managers preferred local evidence, evidence from routine monitoring and evaluation, and reports from service providers. Service providers on the other hand preferred local evidence and routine monitoring and evaluation reports whilst researchers preferred systematic reviews and clinical trials. Stakeholders preferred evidence covering several aspects impacting on decision-making highlighting the fact that although policy actors look for factual information, they also require evidence on context and implementation feasibility of a policy decision. What LICs like Uganda categorize as evidence suitable for informing policy encompasses several types with no consensus on what is deemed as most appropriate. Evidence must be of high quality, applicable, acceptable to the users, and informing different aspects of decision-making. © 2015 by Kerman University of Medical Sciences.

Evidence for Informing Health Policy Development in Low- Income Countries (LICS: Perspectives of Policy Actors in Uganda

Directory of Open Access Journals (Sweden)

Juliet Nabyonga-Orem

2015-05-01

Full Text Available Background Although there is a general agreement on the benefits of evidence informed health policy development given resource constraints especially in Low-Income Countries (LICs, the definition of what evidence is, and what evidence is suitable to guide decision-making is still unclear. Our study is contributing to filling this knowledge gap. We aimed to explore health policy actors’ views regarding what evidence they deemed appropriate to guide health policy development. Methods Using exploratory qualitative methods, we conducted interviews with 51 key informants using an indepth interview guide. We interviewed a diverse group of stakeholders in health policy development and knowledge translation in the Uganda health sector. Data were analyzed using inductive content analysis techniques. Results Different stakeholders lay emphasis on different kinds of evidence. While donors preferred international evidence and Ministry of Health (MoH officials looked to local evidence, district health managers preferred local evidence, evidence from routine monitoring and evaluation, and reports from service providers. Service providers on the other hand preferred local evidence and routine monitoring and evaluation reports whilst researchers preferred systematic reviews and clinical trials. Stakeholders preferred evidence covering several aspects impacting on decision-making highlighting the fact that although policy actors look for factual information, they also require evidence on context and implementation feasibility of a policy decision. Conclusion What LICslike Uganda categorize as evidence suitable for informing policy encompasses several types with no consensus on what is deemed as most appropriate. Evidence must be of high quality, applicable, acceptable to the users, and informing different aspects of decision-making.

Pension Fund Investment Policy

OpenAIRE

Zvi Bodie

1988-01-01

The purpose of this paper is to survey what is known about the investment policy of pension funds. Pension fund investment policy depends critically on the type of plan: defined contribution versus defined benefit. For defined contribution plans investment policy is not much different than it is for an individual deciding how to invest the money in an Individual Retirement Account (IRA). The guiding principle is efficient diversification, that is, achieving the maximum expected return for any...

Direct demonstration of ATP-dependent release of SecA from a translocating preprotein by surface plasmon resonance

NARCIS (Netherlands)

de Keyzer, J; van der Does, C; Kloosterman, TG; Driessen, AJM

2003-01-01

Translocase mediates the transport of preproteins across the inner membrane of Escherichia coli. SecA binds with high affinity to the membrane-embedded protein-conducting SecYEG complex and serves as both a receptor for secretory proteins and as an ATP-driven molecular motor. Cycles of ATP binding

National Environmental Policy Act (NEPA) Source Guide for the Hanford Site

Energy Technology Data Exchange (ETDEWEB)

JANSKY, M.T.

2000-09-01

This Source Guide will assist those working with the National Environmental Policy Act (NEPA) of 1969 to become more familiar with the environmental assessments (EA) and environmental impact statements (EIS) that apply to specific activities and facilities on the Hanford Site. This document should help answer questions concerning NEPA coverage, history, processes, and the status of many of the buildings and units on and related to the Hanford Site. This document summarizes relevant EAs and EISs by briefly outlining the proposed action of each document and the decision made by the U.S. Department of Energy (DOE) or its predecessor agencies, the U.S. Atomic Energy Commission (AEC) and the U.S. Energy Research and Development Administration (ERDA). The summary includes the proposed action alternatives and current status of the proposed action. If a decision officially was stated by the DOE, as in a finding of no significant impact (FONSI) or a record of decision (ROD), and the decision was located, a summary is provided. Not all federal decisions, such as FONSIs and RODs, can be found in the Federal Register (FR). For example, although significant large-action FONSIs can be found in the FR, some low-interest FONSIs might have been published elsewhere (i.e., local newspapers).

77 FR 75362 - Funding and Fiscal Affairs, Loan Policies and Operations, and Funding Operations

Science.gov (United States)

2012-12-20

... FARM CREDIT ADMINISTRATION 12 CFR Part 615 Funding and Fiscal Affairs, Loan Policies and Operations, and Funding Operations CFR Correction 0 In Title 12 of the Code of Federal Regulations, Parts 600 to 899, revised as of January 1, 2012, on page 209, Subpart S, consisting of Sec. 615.5570, is...

Modulation of biosynthesis and regulatory action of 24(S),25-epoxycholesterol (S-EC) in cultured cells by progesterone (PG)

International Nuclear Information System (INIS)

Panini, S.R.; Gupta, A.K.; Sexton, R.C.; Parish, E.J.; Rudney, H.

1987-01-01

Treatment of IEC-6 cells with PG caused a strong inhibition of cholesterol biosynthesis at the level of desmosterol reductase. In addition, two new products were observed in PG-treated cells. The first compound was designated as cholesta-5,7,24-trien-3β-ol based on its HPLC chromatographic properties. The second compound was identified as S-EC based on (1) a comparison of its chromatographic properties with those of authentic EC and (2) by its conversion to 25-hydroxycholesterol (HC) upon reduction with LiAlH 4 . In spite of cellular accumulation of S-EC in the presence of PG, the activity of HMG-CoA reductase (HMGR) which is known to be sensitive to oxysterols, was elevated rather than suppressed. On the other hand, when PG-treated cells were refed fresh medium without PG, HMGR activity was suppressed. Exogenous S-EC was a potent suppressor of HMGR in untreated IEC-6 cells. Suppression of HMGR by S-EC but not by HC could be prevented by progesterone. Exogenous [ 3 H]S-EC was not metabolized by IEC-6 cells. These results support the hypothesis that S-EC plays a normal regulatory role in sterol biosynthesis and indicate that enhanced S-EC synthesis observed in the presence of PG may be due to interference with this regulatory action

Experimental determination of the high-temperature rate constant for the reaction of OH with sec-butanol.

Science.gov (United States)

Pang, Genny A; Hanson, Ronald K; Golden, David M; Bowman, Craig T

2012-10-04

The overall rate constant for the reaction of OH with sec-butanol [CH(3)CH(OH)CH(2)CH(3)] was determined from measurements of the near-first-order OH decay in shock-heated mixtures of tert-butylhydroperoxide (as a fast source of OH) with sec-butanol in excess. Three kinetic mechanisms from the literature describing sec-butanol combustion were used to examine the sensitivity of the rate constant determination to secondary kinetics. The overall rate constant determined can be described by the Arrhenius expression 6.97 × 10(-11) exp(-1550/T[K]) cm(3) molecule(-1) s(-1), valid over the temperature range of 888-1178 K. Uncertainty bounds of ±30% were found to adequately account for the uncertainty in secondary kinetics. To our knowledge, the current data represent the first efforts toward an experimentally determined rate constant for the overall reaction of OH with sec-butanol at combustion-relevant temperatures. A rate constant predicted using a structure-activity relationship from the literature was compared to the current data and previous rate constant measurements for the title reaction at atmospheric-relevant temperatures. The structure-activity relationship was found to be unable to correctly predict the measured rate constant at all temperatures where experimental data exist. We found that the three-parameter fit of 4.95 × 10(-20)T(2.66) exp(+1123/T[K]) cm(3) molecule(-1) s(-1) better describes the overall rate constant for the reaction of OH with sec-butanol from 263 to 1178 K.

The translocon protein Sec61 mediates antigen transport from endosomes in the cytosol for cross-presentation to CD8(+) T cells.

Science.gov (United States)

Zehner, Matthias; Marschall, Andrea L; Bos, Erik; Schloetel, Jan-Gero; Kreer, Christoph; Fehrenschild, Dagmar; Limmer, Andreas; Ossendorp, Ferry; Lang, Thorsten; Koster, Abraham J; Dübel, Stefan; Burgdorf, Sven

2015-05-19

The molecular mechanisms regulating antigen translocation into the cytosol for cross-presentation are under controversial debate, mainly because direct data is lacking. Here, we have provided direct evidence that the activity of the endoplasmic reticulum (ER) translocon protein Sec61 is essential for endosome-to-cytosol translocation. We generated a Sec61-specific intrabody, a crucial tool that trapped Sec61 in the ER and prevented its recruitment into endosomes without influencing Sec61 activity and antigen presentation in the ER. Expression of this ER intrabody inhibited antigen translocation and cross-presentation, demonstrating that endosomal Sec61 indeed mediates antigen transport across endosomal membranes. Moreover, we showed that the recruitment of Sec61 toward endosomes, and hence antigen translocation and cross-presentation, is dependent on dendritic cell activation by Toll-like receptor (TLR) ligands. These data shed light on a long-lasting question regarding antigen cross-presentation and point out a role of the ER-associated degradation machinery in compartments distinct from the ER. Copyright © 2015 Elsevier Inc. All rights reserved.

Describing management attitudes to guide forest policy implementation

DEFF Research Database (Denmark)

Boon, Tove Ragnhild Enggrob; Meilby, Henrik

2007-01-01

management attitudes and practices: (1) the production-oriented owner, (2) the classic forest owner, (3) the environmental/recreational owner, and (4) the indifferent forest owner. Owners in Clusters 1 and 2 are mainly motivated by financial and wood production aspects, whereas owners in Cluster 3......Forest policy in Denmark aims to increase the environmental values of forests. For policy implementation it is essential to know how to motivate private owners. Based on a survey among private forest owners in Denmark, four types of owners have been identified, clustered according to their forest...... are to a greater extent motivated by environmental and recreational aspects. Cluster 4 is the least motivated cluster. For effective policy intervention, the clusters should be addressed by different means. Owners in Clusters 1 and 2 should be met on their agricultural-production logic, Cluster 3 on their interest...

Energy and environment design guide

Energy Technology Data Exchange (ETDEWEB)

Harman, K. [Royal Australian Institute of Architects, Canberra, ACT (Australia)

1996-04-01

The Royal Australian Institute of Architects (RAIA) released an Environment Policy for architects in September 1994 which forms part of the RAIA Code of Professional Conduct. Prior to releasing the policy, it was recognised that members needed information and education in the area of energy and environment in order to adopt and implement the guide. This document is a report on the scope, work programme and achievements of a project to provide an easy reference resource for architects and other building designers, and bring together a wide range of information and research. It includes the Environment Policy as an appendix. The project produced 24 notes entitled the `Environment Design Guide - energy/environment notes` covering a wide range of topics, and four newsletters. Feedback received from architects to date indicates that the development of the notes has had a positive effect on their knowledge of these issues, resulting in the making of informed design decisions. The topics covered by the notes are expected to expand in 1996 with the preparation of additional notes which provide information on products and sustainable construction.

Manual on service business for policy research

International Nuclear Information System (INIS)

1999-01-01

The contents of this book are summary of service business for policy research : conception classification and ways of service business for policy research, propel procedure of service business for policy research on system of committee, management, choice, contract, evaluation and post management, related regulation on service business for policy research : management regulation on service business for policy research, guide of evaluation for service business for policy research, estimation standard of policy research cost, law arrangement of national contract, required document on service business for policy research, and application manual for PRISM.

Respiratory syncytial virus (RSV disease – new data needed to guide future policy

Directory of Open Access Journals (Sweden)

Louis Bont

2015-12-01

Full Text Available RSV is the main cause of childhood lower respiratory infections, globally, an important cause of childhood wheeze and may be responsible for a substantial burden of disease in the very elderly and in adults with chronic medical problems, such as COPD. It is thus responsible for substantial healthcare and social costs. There are currently many companies and academic groups developing and testing candidate vaccines and there is an expectation that these will lead to effective and safe vaccines which will be available to health systems globally in the short- medium term. Despite this, there is an incomplete understanding of RSV disease, especially in adult groups, and large scale data are only available from a few countries and settings leading to low levels of awareness of the importance of this pathogen. We discuss the need for widespread national sentinel systems of RSV surveillance and some means by which this could be achieved. These data will be needed by national policy makers and immunisation advisory groups to guide future priority setting and decision making.

14 CFR Sec. 19-5 - Air transport traffic and capacity elements.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Air transport traffic and capacity elements... AIR CARRIERS Operating Statistics Classifications Sec. 19-5 Air transport traffic and capacity... reported as applicable to specified air transport traffic and capacity elements. (b) These reported items...

76 FR 9210 - Draft DOC National Aquaculture Policy

Science.gov (United States)

2011-02-16

... DEPARTMENT OF COMMERCE Draft DOC National Aquaculture Policy AGENCY: Commerce. ACTION: Notice of availability of draft aquaculture policy; request for comments. SUMMARY: The Department of Commerce (DOC) is... United States. The intent of the policy is to guide DOC's actions and decisions on aquaculture and to...

Targeting cell migration and the endoplasmic reticulum stress response with calmodulin antagonists: a clinically tested small molecule phenocopy of SEC62 gene silencing in human tumor cells

International Nuclear Information System (INIS)

Linxweiler, Maximilian; Greiner, Markus; Schorr, Stefan; Schäuble, Nico; Jung, Martin; Linxweiler, Johannes; Langer, Frank; Schäfers, Hans-Joachim; Cavalié, Adolfo; Zimmermann, Richard

2013-01-01

Tumor cells benefit from their ability to avoid apoptosis and invade other tissues. The endoplasmic reticulum (ER) membrane protein Sec62 is a key player in these processes. Sec62 is essential for cell migration and protects tumor cells against thapsigargin-induced ER stress, which are both linked to cytosolic Ca 2+ . SEC62 silencing leads to elevated cytosolic Ca 2+ and increased ER Ca 2+ leakage after thapsigargin treatment. Sec62 protein levels are significantly increased in different tumors, including prostate, lung and thyroid cancer. In lung cancer, the influence of Sec62 protein levels on patient survival was analyzed using the Kaplan-Meier method and log-rank test. To elucidate the underlying pathophysiological functions of Sec62, Ca 2+ imaging techniques, real-time cell analysis and cell migration assays were performed. The effects of treatment with the calmodulin antagonists, trifluoperazine (TFP) and ophiobolin A, on cellular Ca 2+ homeostasis, cell growth and cell migration were compared with the effects of siRNA-mediated Sec62 depletion or the expression of a mutated SEC62 variant in vitro. Using Biacore analysis we examined the Ca 2+ -sensitive interaction of Sec62 with the Sec61 complex. Sec62 overproduction significantly correlated with reduced patient survival. Therefore, Sec62 is not only a predictive marker for this type of tumor, but also an interesting therapeutic target. The present study suggests a regulatory function for Sec62 in the major Ca 2+ leakage channel in the ER, Sec61, by a direct and Ca 2+ -sensitive interaction. A Ca 2+ -binding motif in Sec62 is essential for its molecular function. Treatment of cells with calmodulin antagonists mimicked Sec62 depletion by inhibiting cell migration and rendering the cells sensitive to thapsigargin treatment. Targeting tumors that overproduce Sec62 with calmodulin antagonists in combination with targeted thapsigargin analogues may offer novel personalized therapeutic options

Guide to National Security Policy and Strategy

National Research Council Canada - National Science Library

Bartholomees, Jr, J. B

2006-01-01

...: Theory of War and Strategy and National Security Policy and Strategy. The result for this book is the expansion of the block on strategic theory and the introduction of a block on specific strategic issues...

Medical and biohazardous waste generator's guide: Revision 1

International Nuclear Information System (INIS)

1994-09-01

This Guide describes the procedures required to comply with all federal and state laws and regulations and Lawrence Berkeley Laboratory (LBL) policy applicable to medical and biohazardous waste. The members of the LBL Biological Safety Subcommittee participated in writing these policies and procedures. The procedures and policies in this Guide apply to LBL personnel who work with infectious agents or potentially infectious agents, publicly perceived infectious items or materials (e.g., medical gloves, culture dishes), and sharps (e.g., needles, syringes, razor blades). If medical or biohazardous waste is contaminated or mixed with a hazardous chemical or material, with a radioactive material, or with both, the waste will be handled in accordance with the applicable federal and State of California laws and regulations for hazardous, radioactive, or mixed waste

Policy Route Map for Academic Libraries' Digital Content

Science.gov (United States)

Koulouris, Alexandros; Kapidakis, Sarantos

2012-01-01

This paper presents a policy decision tree for digital information management in academic libraries. The decision tree is a policy guide, which offers alternative access and reproduction policy solutions according to the prevailing circumstances (for example acquisition method, copyright ownership). It refers to the digital information life cycle,…

Guide to preparing SAND reports. Revised

Energy Technology Data Exchange (ETDEWEB)

Locke, T.K. [ed.

1996-04-01

This guide contains basic information needed to produce a SAND report. Its guidelines reflect DOE regulation and Sandia policy. The guide includes basic writing instructions in an annotated sample report; guidance for organization, format, and layout of reports produced by line organizations; and information about conference papers, journal articles, and brochures. The appendixes contain sections on Sandia`s preferred usage, equations, references, copyrights and permissions, and publishing terms.

National Center for Electron Microscopy users' guide

International Nuclear Information System (INIS)

1987-01-01

The National Center for Electron Microscopy (NCEM) in the Materials and Molecular Research Division of the Lawrence Berkeley Laboratory is a high voltage electron microscope facility for ultra-high resolution or dynamic in-situ studies. This guide describes the instruments and their specifications, support instrumentation, and user policies. Advice as to travel and accommodations is provided in the guide. (FI)

The Solar Neighborhood. XXV. Discovery of New Proper Motion Stars with 0.40 sec/yr > mu > or = 0.18 sec/yr Between Declinations -47 deg and 00 deg

Science.gov (United States)

Boyd, Mark R.; Winters, Jennifer G.; Henry, Todd J.; Jao, Wei-Chun; Finch, Charlie T.; Subasavage, John P.; Hambly, Nigel C.

2011-01-01

We present 2817 new southern proper motion systems with 0.40 sec/yr > mu > or = 0.18 sec/yr and declination between 47 deg and 00 deg. This is a continuation of the SuperCOSMOS-RECONS (SCR) proper motion searches of the southern sky. We use the same photometric relations as previous searches to provide distance estimates based on the assumption that the objects are single main-sequence stars. We find 79 new red dwarf systems predicted to be within 25 pc, including a few new components of previously known systems. Two systems--SCR 1731-2452 at 9.5 pc and SCR 1746-3214 at 9.9 pc--are anticipated to be within 10 pc. We also find 23 new white dwarf (WD) candidates with distance estimates of 15-66 pc, as well as 360 new red subdwarf candidates. With this search, we complete the SCR sweep of the southern sky for stars with mu > or = 0.18 sec/yr and R(sub 59F) < or = 16.5, resulting in a total of 5042 objects in 4724 previously unreported proper motion systems. Here we provide selected comprehensive lists from our SCR proper motion search to date, including 152 red dwarf systems estimated to be within 25 pc (9 within 10 pc), 46 WDs (10 within 25 pc), and 598 subdwarf candidates. The results of this search suggest that there are more nearby systems to be found at fainter magnitudes and lower proper motion limits than those probed so far.

Health care models guiding mental health policy in Kenya 1965 - 1997

Directory of Open Access Journals (Sweden)

Jenkins Rachel

2010-04-01

Full Text Available Abstract Background Mental health policy is needed to set the strategy and direction for the provision of mental health services in a country. Policy formulation does not occur in a vacuum, however, but is influenced by local and international factors in the health sector and other sectors. Methods This study was carried out in 1997 to examine the evolution of mental health policy in Kenya between 1965 and 1997 in the context of changing international concepts of health and development. Qualitative content analysis of policy documents was combined with interviews of key policy makers. Results The study showed that during the period 1965-1997 the generic health policy in Kenya changed from one based on the Medical Model in the 1960s and 1970s to one based on the Primary Health Care Model in the late 1970s and the 1980s and finally to one based on the Market Model of health care in the 1990s. The mental health policy, on the other hand, evolved from one based on the Medical Model in the 1960s to one based on the Primary Health Care Model in the 1990s, but did not embrace the Market Model of health care. This resulted in a situation in the 1990s where the mental health policy was rooted in a different conceptual model from that of the generic health policy under which it was supposed to be implemented. This "Model Muddlement" may have impeded the implementation of the mental health policy in Kenya. Conclusions Integration of the national mental health policy with the general health policy and other sector policies would be appropriate and is now underway.

Generating randomised virtualised scenarios for ethical hacking and computer security education: SecGen implementation and deployment

OpenAIRE

Schreuders, ZC; Ardern, L

2015-01-01

Computer security students benefit from having hands-on experience with hacking tools and with access to vulnerable systems that they can attack and defend. However, vulnerable VMs are static; once they have been exploited by a student there is no repeatable challenge as the vulnerable boxes never change. A new novel solution, SecGen, has been created and deployed. SecGen solves the issue by creating vulnerable machines with randomised vulnerabilities and services, with constraints that ensur...

The World Health Organization (WHO) dataset for guiding suicide prevention policies: A 3-decade French national survey.

Science.gov (United States)

Fond, Guillaume; Zendjidjian, Xavier; Boucekine, Mohamed; Brunel, Lore; Llorca, Pierre-Michel; Boyer, Laurent

2015-12-01

Public health policies aim to prevent suicide in the general population. Assessing their effectiveness is required to further guide public health policies. The present article focuses on the French paradox. The French health care system was classified as the best in the world according the World Health Organization (WHO). However, suicide rates in France remain high compared to other European countries. The aim of the present article was to analyze (i) the evolution of suicide Age-Standardized Death (ASDRs) in France during the last three decades and the associations with socio-economic parameters and (ii) to understand which populations may specifically benefit from further targeted suicide prevention policies. The database of the World Health Organization (WHO), freely available, was explored in April 2015. ASDRs were calculated each year by ratio between the number of deaths by suicide and the total population (per 100,000 inhabitants). Number of deaths by gender and age were also analyzed. Overall, ASDR suicide has decreased since 1987 in France (-32.8% between 1987 and 2010). However, France kept the same rank (10/26) when compared to other European countries between 1987 and 2010. The relative burden of suicide in all-causes mortality increased during the same period (+28.2%) while the total number of deaths by suicide increased only slightly (+3.9%). More specifically, the number of deaths by suicide increased substantially in [35-54] years old (+40%) and 75+ years old (+27%) males, and in [35-54] (+41%) years old females. Between 2000 and 2010, suicide rates significantly decreased when yearly mean income increased, and when general and psychiatric care beds decreased. Although ASDR suicide has decreased in France since 1987, this decline is quite modest when considering its universal access to care, the prevention of depression and suicide public policies. Suicide prevention public policies should focus on evaluation and improvement of prevention and care

Newborn bloodspot screening policy framework for Australia

Directory of Open Access Journals (Sweden)

Peter O'Leary

2015-09-01

Full Text Available Background The aim of newborn bloodspot screening (NBS is to identify rare genetic and non-genetic conditions in children soon after birth in order to commence therapies that prevent the development of progressive, serious, and irreversible disabilities. Universal NBS programmes have been implemented in most countries, with minor adaptations to target conditions most relevant to the local healthcare environment. Aims In this article, we describe the initiatives of international and Australian governments to develop policies to address the expansion of NBS in their healthcare systems. Methods We have reviewed published public policies and literature to formulate recommendations based on clinical, social, legal, and ethical principles to inform a national governance and policy framework for Australia. Results Australian policy makers have been slow to develop a coordinated plan. While the experience from other governments can guide our national policy, there are specific areas that require further consideration by Australian health experts. Key reforms involve the separation of policy and operational activities, multidisciplinary decision-making and oversight by the Australian Health Ministers’ Advisory Council for policy direction. Conclusion A formal national policy framework will guide the coordination of NBS services that can adapt to the needs of Australian children and families.

Macro-environmental policy: Principles and design

International Nuclear Information System (INIS)

Huppes, G.

1993-01-01

The central theme of this book is how macro-environmental policy can be developed, which does not prescribe or suggest specific technologies and products bu realizes the environmental quality desired by changing the general context. The publication is composed of four main parts. The framework for analysis and the normative principles for policy design and evaluation, the first two parts, form the analytic core. The framework for analysis gives a classification of instruments in terms of permutations of a limited number of defining elements. The normative principles guide choices in instrument design and, as the flexible response strategy, guide their application in specific policies. Detailing two main new instruments (the standard method for life cycle analysis and the substance deposit, and applying the instrument strategy as developed to the cases make up the next two parts

Data Speak: Influencing School Health Policy through Research

Science.gov (United States)

Ryberg, Jacalyn Wickline; Keller, Teresa; Hine, Beverly; Christeson, Elisabeth

2003-01-01

School nurses occupy a unique position in relation to school health policy. In addition to facing the demands of promoting and maintaining the health of students, they collect the information that is used to document the implementation of school health policy. Effective school health policy is guided by reliable, credible data regarding what…

The SecA2 pathway of Mycobacterium tuberculosis exports effectors that work in concert to arrest phagosome and autophagosome maturation.

Science.gov (United States)

Zulauf, Katelyn E; Sullivan, Jonathan Tabb; Braunstein, Miriam

2018-04-30

To subvert host defenses, Mycobacterium tuberculosis (Mtb) avoids being delivered to degradative phagolysosomes in macrophages by arresting the normal host process of phagosome maturation. Phagosome maturation arrest by Mtb involves multiple effectors and much remains unknown about this important aspect of Mtb pathogenesis. The SecA2 dependent protein export system is required for phagosome maturation arrest and consequently growth of Mtb in macrophages. To better understand the role of the SecA2 pathway in phagosome maturation arrest, we identified two effectors exported by SecA2 that contribute to this process: the phosphatase SapM and the kinase PknG. Then, utilizing the secA2 mutant of Mtb as a platform to study effector functions, we identified specific steps in phagosome maturation inhibited by SapM and/or PknG. By identifying a histidine residue that is essential for SapM phosphatase activity, we confirmed for the first time that the phosphatase activity of SapM is required for its effects on phagosome maturation in macrophages. We further demonstrated that SecA2 export of SapM and PknG contributes to the ability of Mtb to replicate in macrophages. Finally, we extended our understanding of the SecA2 pathway, SapM, and PknG by revealing that their contribution goes beyond preventing Mtb delivery to mature phagolysosomes and includes inhibiting Mtb delivery to autophagolysosomes. Together, our results revealed SapM and PknG to be two effectors exported by the SecA2 pathway of Mtb with distinct as well as cumulative effects on phagosome and autophagosome maturation. Our results further reveal that Mtb must have additional mechanisms of limiting acidification of the phagosome, beyond inhibiting recruitment of the V-ATPase proton pump to the phagosome, and they indicate differences between effects of Mtb on phagosome and autophagosome maturation.

Systematically reviewing and synthesizing evidence from conversation analytic and related discursive research to inform healthcare communication practice and policy: an illustrated guide.

Science.gov (United States)

Parry, Ruth H; Land, Victoria

2013-05-30

Healthcare delivery is largely accomplished in and through conversations between people, and healthcare quality and effectiveness depend enormously upon the communication practices employed within these conversations. An important body of evidence about these practices has been generated by conversation analysis and related discourse analytic approaches, but there has been very little systematic reviewing of this evidence. We developed an approach to reviewing evidence from conversation analytic and related discursive research through the following procedures: • reviewing existing systematic review methods and our own prior experience of applying these • clarifying distinctive features of conversation analytic and related discursive work which must be taken into account when reviewing • holding discussions within a review advisory team that included members with expertise in healthcare research, conversation analytic research, and systematic reviewing • attempting and then refining procedures through conducting an actual review which examined evidence about how people talk about difficult future issues including illness progression and dying We produced a step-by-step guide which we describe here in terms of eight stages, and which we illustrate from our 'Review of Future Talk'. The guide incorporates both established procedures for systematic reviewing, and new techniques designed for working with conversation analytic evidence. The guide is designed to inform systematic reviews of conversation analytic and related discursive evidence on specific domains and topics. Whilst we designed it for reviews that aim at informing healthcare practice and policy, it is flexible and could be used for reviews with other aims, for instance those aiming to underpin research programmes and projects. We advocate systematically reviewing conversation analytic and related discursive findings using this approach in order to translate them into a form that is credible and

Rural Development Policy: Promises Made and Promises Denied.

Science.gov (United States)

Hyman, Drew

1991-01-01

Presents historical trends toward rural development policy. Describes the agrarian perspective and the industrial and urbanization perspective as current visions which guide policy. Recommends a new vision focusing on "livability for people" and "viability of community systems." (KS)

Recent Changes in UC Admissions Policies. Parent/Student Guide = Unos cambios recientes en los reglamentos de ingreso de la universidad de California. Guia de padres/estudiantes.

Science.gov (United States)

EdSource, Inc., Palo Alto, CA.

This parent/student guide describes recent changes in admissions policies at the University of California (UC). Traditionally, UC admitted the top 12.5% of high school graduating seniors, but beginning in 2001, the top 4% of students in the graduating class of every high school are eligible if they have completed 11 specific "a-f"…

Cloning, purification, crystallization and preliminary crystallographic analysis of SecA from Enterococcus faecalis

International Nuclear Information System (INIS)

Meining, Winfried; Scheuring, Johannes; Fischer, Markus; Weinkauf, Sevil

2006-01-01

SecA ATPase from E. faecalis has been cloned, overexpressed, purified and crystallized. Crystals belong to space group C2 and diffract to 2.4 Å resolution. The gene coding for SecA from Enterococcus faecalis was cloned and overexpressed in Escherichia coli. In this protein, the lysine at position 6 was replaced by an asparagine in order to reduce sensitivity towards proteases. The modified protein was purified and crystallized. Crystals diffracting to 2.4 Å resolution were obtained using the vapour-diffusion technique. The crystals belong to the monoclinic space group C2, with unit-cell parameters a = 203.4, b = 49.8, c = 100.8 Å, α = γ = 90.0, β = 119.1°. A selenomethionine derivative was prepared and is currently being tested in crystallization trials

75 FR 27028 - Joint CFTC-SEC Advisory Committee on Emerging Regulatory Issues

Science.gov (United States)

2010-05-13

... regulatory issues and their potential impact on investors and the securities markets. The Committee will lend... SECURITIES AND EXCHANGE COMMISSION [Release No. 33-9123; File No. 265-26] COMMODITY FUTURES TRADING COMMISSION Joint CFTC-SEC Advisory Committee on Emerging Regulatory Issues AGENCY: Securities and...

76 FR 80817 - Funding and Fiscal Affairs, Loan Policies and Operations, and Funding Operations; Liquidity and...

Science.gov (United States)

2011-12-27

... banks may pay more attention to the financial performance of the liquidity reserve rather than its role... policies. As with all other aspects of the bank's operations, an explicit delegation of authority within a..., proposed Sec. 615.5134(b) and (e) would divide the bank's liquidity reserve into two levels. The first...

Companies and Climate Risk: Opportunities to Engage the Business Community in Promoting Climate-conscious Policies (Invited)

Science.gov (United States)

Goldman, G. T.; Rogerson, P.

2013-12-01

Regardless of their policy orientation, the business community has an interest in how climate change impacts will affect their operations and ultimately change their bottom line. The reality that climate change presents material and financial risks to many companies in diverse sectors of the economy presents an opportunity to engage companies on climate-related issues. Company investors are exposed to such financial risks and can pressure public companies to change behavior through shareholder resolutions, voting, and election of new board members. The US Securities and Exchange Commission (SEC) obligates all publicly traded companies to discuss risks that might materially affect their business in their annual Form 10-K filings. In 2010, the guidance for the Form 10-K specifically suggested that companies consider and discuss any significant risks to their business from climate change--both from its physical effects and from impacts of climate regulations. Form 10-Ks for 28 US companies were analyzed for the years 2009 and 2010. Results indicate that some companies comprehensively considered climate-related risks. However, in spite of the SEC guidance, some fail to mention climate change at all. Additionally, many companies discuss only the impacts that regulation would have on their business--not the physical effects of climate change itself. The lack of consideration of climate-related risks in companies' risk assessments demonstrates a need for a more uniform understanding of SEC requirements and additionally, this state of affairs presents an opportunity to push companies to more deeply consider climate change impacts. Several avenues are available for engaging with companies themselves, their shareholders, the SEC, and the public. We will explore what strategies have been effective for engaging such actors and what further opportunities exist for working with the business community to promote more climate-conscious policies and practices.

Random maintenance policies

CERN Document Server

Nakagawa, Toshio

2014-01-01

Exploring random maintenance models, this book provides an introduction to the implementation of random maintenance, and it is one of the first books to be written on this subject.  It aims to help readers learn new techniques for applying random policies to actual reliability models, and it provides new theoretical analyses of various models including classical replacement, preventive maintenance and inspection policies. These policies are applied to scheduling problems, backup policies of database systems, maintenance policies of cumulative damage models, and reliability of random redundant systems. Reliability theory is a major concern for engineers and managers, and in light of Japan’s recent earthquake, the reliability of large-scale systems has increased in importance. This also highlights the need for a new notion of maintenance and reliability theory, and how this can practically be applied to systems. Providing an essential guide for engineers and managers specializing in reliability maintenance a...

Medical and biohazardous waste generator`s guide: Revision 1

Energy Technology Data Exchange (ETDEWEB)

1994-09-01

This Guide describes the procedures required to comply with all federal and state laws and regulations and Lawrence Berkeley Laboratory (LBL) policy applicable to medical and biohazardous waste. The members of the LBL Biological Safety Subcommittee participated in writing these policies and procedures. The procedures and policies in this Guide apply to LBL personnel who work with infectious agents or potentially infectious agents, publicly perceived infectious items or materials (e.g., medical gloves, culture dishes), and sharps (e.g., needles, syringes, razor blades). If medical or biohazardous waste is contaminated or mixed with a hazardous chemical or material, with a radioactive material, or with both, the waste will be handled in accordance with the applicable federal and State of California laws and regulations for hazardous, radioactive, or mixed waste.

Knowledge Management in Scientific and Technical Support Organizations for Regulatory Bodies: SEC NRS Experience

International Nuclear Information System (INIS)

Saulskaya, N.

2016-01-01

Full text: Nuclear industry, similar to other high-tech industries, is based on knowledge and to a great extent depends on personnel qualification, their skills and abilities. Knowledge management processes were recognized of the utmost importance for the IAEA. The IAEA GA adopted a number of resolutions on nuclear knowledge. In this context, knowledge management is considered as an integrated, systematic approach to the process of assessment, obtaining, development, distribution, use, transfer and maintenance of knowledge related to achievement of strategic targets of organization development. KM makes it possible to learn lessons from its own experience. The report presents a long-term experience of SEC NRS in knowledge management and capacity building, which is critically important for SEC NRS as scientific and technical support organization for Rostechnadzor. KM in SEC NRS is performed through the HRM, primarily through HRD, assessment, motivation of the labor activity, and regulation of social-psychological processes. The practice of implementation of NKM through the functions of human resources management is of particular interest for embarking countries. The best practices will be reflected in the IAEA Safety Report “Knowledge Management for Regulatory Bodies and TSO”, which is currently being developed by a team of the IAEA experts. (author

Information security policy development for compliance

CERN Document Server

Williams, Barry L

2013-01-01

Although compliance standards can be helpful guides to writing comprehensive security policies, many of the standards state the same requirements in slightly different ways. Information Security Policy Development for Compliance: ISO/IEC 27001, NIST SP 800-53, HIPAA Standard, PCI DSS V2.0, and AUP V5.0 provides a simplified way to write policies that meet the major regulatory requirements, without having to manually look up each and every control. Explaining how to write policy statements that address multiple compliance standards and regulatory requirements, the book will he

Experimental determination of the isothermal (vapour + liquid) equilibria of binary aqueous solutions of sec-butylamine and cyclohexylamine at several temperatures

Energy Technology Data Exchange (ETDEWEB)

Chiali-Baba Ahmed, Nouria [LATA2M, Laboratoire de Thermodynamique Appliquee et Modelisation Moleculaire, University AbouBekr Belkaid of Tlemcen, Post Office Box 119, Tlemcen 13000 (Algeria); Negadi, Latifa, E-mail: latifanegadi@yahoo.fr [LATA2M, Laboratoire de Thermodynamique Appliquee et Modelisation Moleculaire, University AbouBekr Belkaid of Tlemcen, Post Office Box 119, Tlemcen 13000 (Algeria); Mokbel, Ilham [LSA, Laboratoire des Sciences Analytiques, CNRS-UMR 5280, Universite Claude Bernard - Lyon I, 43, Bd du 11 Novembre 1918, Villeurbanne Cedex 69622 (France); Kaci, Ahmed Ait [Laboratoire de Thermodynamique et Modelisation Moleculaire, Universite des Sciences et de la Technologie Houari Boumediene, Post Office Box 32, El Alia 16111, Bab Ezzouar (Algeria); Jose, Jacques [LSA, Laboratoire des Sciences Analytiques, CNRS-UMR 5280, Universite Claude Bernard - Lyon I, 43, Bd du 11 Novembre 1918, Villeurbanne Cedex 69622 (France)

2012-01-15

Highlights: > Vapour pressures of sec-butylamine or cyclohexylamine and their aqueous solutions. > The investigated temperatures are 273 K and 363 K. > The (cyclohexylamine + water) mixture shows positive azeotropic behaviour. > The (sec-butylamine + water) or (cyclohexylamine + water) exhibit positive G{sup E}. - Abstract: The vapour pressures of (sec-butylamine + water), (cyclohexylamine + water) binary mixtures, and of pure sec-butylamine and cyclohexylamine components were measured by means of two static devices at temperatures between 293 (or 273) K and 363 K. The data were correlated with the Antoine equation. From these data, excess Gibbs functions (G{sup E}) were calculated for several constant temperatures and fitted to a fourth-order Redlich-Kister equation using the Barker's method. The (cyclohexylamine + water) system shows positive azeotropic behaviour for all investigated temperatures. The two binary mixtures exhibit positive deviations in G{sup E} for all investigated temperatures over the whole composition range.

Coastal and river flood risk analyses for guiding economically optimal flood adaptation policies: a country-scale study for Mexico

Science.gov (United States)

Haer, Toon; Botzen, W. J. Wouter; van Roomen, Vincent; Connor, Harry; Zavala-Hidalgo, Jorge; Eilander, Dirk M.; Ward, Philip J.

2018-06-01

Many countries around the world face increasing impacts from flooding due to socio-economic development in flood-prone areas, which may be enhanced in intensity and frequency as a result of climate change. With increasing flood risk, it is becoming more important to be able to assess the costs and benefits of adaptation strategies. To guide the design of such strategies, policy makers need tools to prioritize where adaptation is needed and how much adaptation funds are required. In this country-scale study, we show how flood risk analyses can be used in cost-benefit analyses to prioritize investments in flood adaptation strategies in Mexico under future climate scenarios. Moreover, given the often limited availability of detailed local data for such analyses, we show how state-of-the-art global data and flood risk assessment models can be applied for a detailed assessment of optimal flood-protection strategies. Our results show that especially states along the Gulf of Mexico have considerable economic benefits from investments in adaptation that limit risks from both river and coastal floods, and that increased flood-protection standards are economically beneficial for many Mexican states. We discuss the sensitivity of our results to modelling uncertainties, the transferability of our modelling approach and policy implications. This article is part of the theme issue `Advances in risk assessment for climate change adaptation policy'.

Classification guide: Paralympic Games London 2012

OpenAIRE

2013-01-01

The London 2012 Paralympic Games Classification Guide is designed to provide National Paralympic Committees (NPCs) and International Paralympic Sport Federations (IPSFs) with information about the classification policies and procedures that will apply to the London 2012 Paralympic Games.

14 CFR Sec. 2-3 - Distribution of revenues and expenses within entities.

Science.gov (United States)

2010-01-01

... CERTIFICATED AIR CARRIERS General Accounting Provisions Sec. 2-3 Distribution of revenues and expenses within.... (c) Expense items contributing to more than one function shall be charged to the general overhead functions to which applicable except that where only incidental contribution is made to more than a single...

Neofunctionalization of the Sec1 α1,2fucosyltransferase paralogue in leporids contributes to glycan polymorphism and resistance to rabbit hemorrhagic disease virus.

Directory of Open Access Journals (Sweden)

Kristina Nyström

2015-04-01

Full Text Available RHDV (rabbit hemorrhagic disease virus, a virulent calicivirus, causes high mortalities in European rabbit populations (Oryctolagus cuniculus. It uses α1,2fucosylated glycans, histo-blood group antigens (HBGAs, as attachment factors, with their absence or low expression generating resistance to the disease. Synthesis of these glycans requires an α1,2fucosyltransferase. In mammals, there are three closely located α1,2fucosyltransferase genes rSec1, rFut2 and rFut1 that arose through two rounds of duplications. In most mammalian species, Sec1 has clearly become a pseudogene. Yet, in leporids, it does not suffer gross alterations, although we previously observed that rabbit Sec1 variants present either low or no activity. Still, a low activity rSec1 allele correlated with survival to an RHDV outbreak. We now confirm the association between the α1,2fucosyltransferase loci and survival. In addition, we show that rabbits express homogenous rFut1 and rFut2 levels in the small intestine. Comparison of rFut1 and rFut2 activity showed that type 2 A, B and H antigens recognized by RHDV strains were mainly synthesized by rFut1, and all rFut1 variants detected in wild animals were equally active. Interestingly, rSec1 RNA levels were highly variable between individuals and high expression was associated with low binding of RHDV strains to the mucosa. Co-transfection of rFut1 and rSec1 caused a decrease in rFut1-generated RHDV binding sites, indicating that in rabbits, the catalytically inactive rSec1 protein acts as a dominant-negative of rFut1. Consistent with neofunctionalization of Sec1 in leporids, gene conversion analysis showed extensive homogenization between Sec1 and Fut2 in leporids, at variance with its limited degree in other mammals. Gene conversion additionally involving Fut1 was also observed at the C-terminus. Thus, in leporids, unlike in most other mammals where it became extinct, Sec1 evolved a new function with a dominant-negative effect

In vitro activity of SecA inhibitors in combination with carbapenems against carbapenem-hydrolysing class D β-lactamase-producing Acinetobacter baumannii.

Science.gov (United States)

Chiu, Chun-Hsiang; Liu, Yu-Han; Wang, Yung-Chih; Lee, Yi-Tzu; Kuo, Shu-Chen; Chen, Te-Li; Lin, Jung-Chung; Wang, Fu-Der

2016-12-01

According to our previous study, OXA-58 translocates to the periplasm via the Sec pathway in carbapenem-resistant Acinetobacter baumannii (CRAb). In the present study, carbapenem-hydrolysing class D β-lactamases (CHDLs) belonging to the OXA-23, OXA-40 and OXA-51 families were examined to determine whether they are also Sec-dependent. Additionally, the effects of SecA inhibitors combined with carbapenems against CHDL-producing CRAb were examined. Cell fractionation and western blot analyses were performed to detect periplasmic His-tagged CHDLs. A chequerboard analysis with pairwise combinations of carbapenems (imipenem or meropenem) and SecA inhibitors (rose bengal, sodium azide or erythrosin B) was performed using six clinical CRAb isolates harbouring different CHDL genes. The fractional inhibitory concentration (FIC) index was determined. The combination with the lowest FIC index was subjected to a time-kill analysis to examine synergistic effects. In an in silico analysis, the CHDLs OXA-23, OXA-40 and OXA-51 were preferentially translocated via the Sec system. The SecA inhibitor rose bengal decreased periplasmic translocation of His-tagged OXA-23 and OXA-83 (belonging to the OXA-51 family), but not OXA-72 (belonging to the OXA-40 family) from ATCC 15151 transformants. Imipenem or meropenem with rose bengal showed synergistic effects (FIC index, ≤0.5) for six and four clinical isolates, respectively. Imipenem or meropenem with sodium azide showed no interactions (FIC index, 0.5-4) against all clinical isolates. Imipenem and rose bengal had the lowest FIC index and showed synergy at 24 h in the time-kill assay. Combinations of SecA inhibitors and carbapenems have synergistic effects against CHDL-producing CRAb. © The Author 2016. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Botswana - Accrual Accounting Policy Note and Guide

OpenAIRE

World Bank

2011-01-01

This paper comprises two volumes: volume one, this concise policy and guidance note that deals with the request as outlined, and a volume two which provides more detailed technical guidance on the implementation of International Public Sector accounting Standards (IPSAS) accrual based standards. Recommended reforms directly relevant to this paper include: 1) fiscal reforms on both the reve...

The Power of Folk Linguistic Knowledge in Language Policy

Science.gov (United States)

Albury, Nathan John

2017-01-01

Just as an expanded view of language policy now affords agency to many more actors across society than authorities and linguists alone, it also accepts that the dispositions these agents bring to language affairs influence language policy processes and outcomes. However, this paper makes the case that language policy may also be guided, to some…

Proteins Related to the Type I Secretion System Are Associated with Secondary SecA_DEAD Domain Proteins in Some Species of Planctomycetes, Verrucomicrobia, Proteobacteria, Nitrospirae and Chlorobi.

Directory of Open Access Journals (Sweden)

Olga K Kamneva

Full Text Available A number of bacteria belonging to the PVC (Planctomycetes-Verrucomicrobia-Chlamydiae super-phylum contain unusual ribosome-bearing intracellular membranes. The evolutionary origins and functions of these membranes are unknown. Some proteins putatively associated with the presence of intracellular membranes in PVC bacteria contain signal peptides. Signal peptides mark proteins for translocation across the cytoplasmic membrane in prokaryotes, and the membrane of the endoplasmic reticulum in eukaryotes, by highly conserved Sec machinery. This suggests that proteins might be targeted to intracellular membranes in PVC bacteria via the Sec pathway. Here, we show that canonical signal peptides are significantly over-represented in proteins preferentially present in PVC bacteria possessing intracellular membranes, indicating involvement of Sec translocase in their cellular targeting. We also characterized Sec proteins using comparative genomics approaches, focusing on the PVC super-phylum. While we were unable to detect unique changes in Sec proteins conserved among membrane-bearing PVC species, we identified (1 SecA ATPase domain re-arrangements in some Planctomycetes, and (2 secondary SecA_DEAD domain proteins in the genomes of some Planctomycetes, Verrucomicrobia, Proteobacteria, Nitrospirae and Chlorobi. This is the first report of potentially duplicated SecA in Gram-negative bacteria. The phylogenetic distribution of secondary SecA_DEAD domain proteins suggests that the presence of these proteins is not related to the occurrence of PVC endomembranes. Further genomic analysis showed that secondary SecA_DEAD domain proteins are located within genomic neighborhoods that also encode three proteins possessing domains specific for the Type I secretion system.

A novel method for feasibility testing urban sustainable development policies

OpenAIRE

O’Doherty Travis; Fitzgerald Brian G.; Moles Richard; O’Regan Bernadette

2013-01-01

Policy making to promote more sustainable development is a complex task due in part to the large number of both stakeholders and potential policies. Policy feasibility testing provides a guide to the viability and practicality of policy implementation and forms an important part of an evidence based policy making process. An extensive literature review has identified no standardized approach to feasibility testing. This paper addresses this knowledge gap by...

Extreme Ultraviolet Solar Images Televised In-Flight with a Rocket-Borne SEC Vidicon System.

Science.gov (United States)

Tousey, R; Limansky, I

1972-05-01

A TV image of the entire sun while an importance 2N solar flare was in progress was recorded in the extreme ultraviolet (XUV) radiation band 171-630 A and transmitted to ground from an Aerobee-150 rocket on 4 November 1969 using S-band telemetry. The camera tube was a Westinghouse Electric Corporation SEC vidicon, with its fiber optic faceplate coated with an XUV to visible conversion layer of p-quaterphenyl. The XUV passband was produced by three 1000-A thick aluminum filters in series together with the platinized reflecting surface of the off-axis paraboloid that imaged the sun. A number of images were recorded with integration times between 1/30 see and 2 sec. Reconstruction of pictures was enhanced by combining several to reduce the noise.

Position-dependent Effects of Polylysine on Sec Protein Transport*

Science.gov (United States)

Liang, Fu-Cheng; Bageshwar, Umesh K.; Musser, Siegfried M.

2012-01-01

The bacterial Sec protein translocation system catalyzes the transport of unfolded precursor proteins across the cytoplasmic membrane. Using a recently developed real time fluorescence-based transport assay, the effects of the number and distribution of positive charges on the transport time and transport efficiency of proOmpA were examined. As expected, an increase in the number of lysine residues generally increased transport time and decreased transport efficiency. However, the observed effects were highly dependent on the polylysine position in the mature domain. In addition, a string of consecutive positive charges generally had a more significant effect on transport time and efficiency than separating the charges into two or more charged segments. Thirty positive charges distributed throughout the mature domain resulted in effects similar to 10 consecutive charges near the N terminus of the mature domain. These data support a model in which the local effects of positive charge on the translocation kinetics dominate over total thermodynamic constraints. The rapid translocation kinetics of some highly charged proOmpA mutants suggest that the charge is partially shielded from the electric field gradient during transport, possibly by the co-migration of counter ions. The transport times of precursors with multiple positively charged sequences, or “pause sites,” were fairly well predicted by a local effect model. However, the kinetic profile predicted by this local effect model was not observed. Instead, the transport kinetics observed for precursors with multiple polylysine segments support a model in which translocation through the SecYEG pore is not the rate-limiting step of transport. PMID:22367204

Position-dependent effects of polylysine on Sec protein transport.

Science.gov (United States)

Liang, Fu-Cheng; Bageshwar, Umesh K; Musser, Siegfried M

2012-04-13

The bacterial Sec protein translocation system catalyzes the transport of unfolded precursor proteins across the cytoplasmic membrane. Using a recently developed real time fluorescence-based transport assay, the effects of the number and distribution of positive charges on the transport time and transport efficiency of proOmpA were examined. As expected, an increase in the number of lysine residues generally increased transport time and decreased transport efficiency. However, the observed effects were highly dependent on the polylysine position in the mature domain. In addition, a string of consecutive positive charges generally had a more significant effect on transport time and efficiency than separating the charges into two or more charged segments. Thirty positive charges distributed throughout the mature domain resulted in effects similar to 10 consecutive charges near the N terminus of the mature domain. These data support a model in which the local effects of positive charge on the translocation kinetics dominate over total thermodynamic constraints. The rapid translocation kinetics of some highly charged proOmpA mutants suggest that the charge is partially shielded from the electric field gradient during transport, possibly by the co-migration of counter ions. The transport times of precursors with multiple positively charged sequences, or "pause sites," were fairly well predicted by a local effect model. However, the kinetic profile predicted by this local effect model was not observed. Instead, the transport kinetics observed for precursors with multiple polylysine segments support a model in which translocation through the SecYEG pore is not the rate-limiting step of transport.

Policy Pathways: Monitoring, Verification and Enforcement

Energy Technology Data Exchange (ETDEWEB)

NONE

2010-07-01

The IEA estimates that, if implemented globally without delay, the 25 IEA Energy Efficiency recommendations could save 8.2 Gt CO2 per year by 2030. Yet many governments struggle with their implementation and thus miss a great part of the energy efficiency potential. The new IEA series Policy Pathways: Showing the way to energy efficiency implementation now aims to assist countries with improving energy efficiency policies. It features practical 'how-to' guides for designing, implementing and evaluating energy efficiency policies and achieving greater improvement.

Policy Pathways: Monitoring, Verification and Enforcement

Energy Technology Data Exchange (ETDEWEB)

NONE

2010-07-01

The IEA estimates that, if implemented globally without delay, the 25 IEA Energy Efficiency recommendations could save 8.2 Gt CO2 per year by 2030. Yet many governments struggle with their implementation and thus miss a great part of the energy efficiency potential. The new IEA series Policy Pathways: Showing the way to energy efficiency implementation now aims to assist countries with improving energy efficiency policies. It features practical 'how-to' guides for designing, implementing and evaluating energy efficiency policies and achieving greater improvement.

Good practice guide to internal flexibility policies in companies

NARCIS (Netherlands)

Goudswaard, A.; Oeij, P.; Brugman, T.

2009-01-01

This report sets out to contribute to the present debate on the need for European companies and their workers to become more flexible and adaptable in the face of ongoing economic change and business restructuring. The guide should therefore provide useful and practical tips for company-level actors

76 FR 58398 - Revised Guidance on Marketed Unapproved Drugs; Compliance Policy Guide Sec. 440.100; Marketed New...

Science.gov (United States)

2011-09-21

... guidance the manufacture and marketing of newly introduced unapproved drugs. This guidance represents the... United States that do not have required FDA approval for marketing. CPG 440.100 has been revised to state..., 2011. All unapproved new drugs introduced onto the market after that date are subject to immediate...

78 FR 20326 - Draft Compliance Policy Guide Sec. 100.250 Food Facility Registration-Human and Animal Food...

Science.gov (United States)

2013-04-04

... before it begins work on the final version of the CPG, submit either electronic or written comments on... reasonable probability of causing serious adverse health consequences or death to humans or animals, FDA may... registration. The draft CPG also contains information that may be useful for the regulated industry and to the...

77 FR 55480 - Draft Compliance Policy Guide Sec. 690.150 on Labeling and Marketing of Nutritional Products...

Science.gov (United States)

2012-09-10

... purpose of this CPG is to communicate FDA's strategy with respect to dog and cat food products that are... for Use To Diagnose, Cure, Mitigate, Treat, or Prevent Disease in Dogs and Cats; Availability AGENCY..., Treat, or Prevent Disease in Dogs and Cats.'' This draft CPG is intended to provide guidance to FDA...

Building sustainable policy framework for transport development: A review of national transport policy initiatives in Nigeria

Directory of Open Access Journals (Sweden)

Sumaila A.F.

2013-06-01

Full Text Available This paper is concerned with building a sustainable policy framework for transport development in Nigeria. Its objective is to review the country’s transport policy initiatives in order to understand the extent to which it addresses Nigeria’s mobility and transportation problems. From published materials and official government documents and files, the study identifies four national policy initiatives which are reviewed and analysed with regard to their context, contents, and consequences. The study reveals that while the policy initiatives could be said to be adequate and comprehensive in terms of their context and contents, the major challenge is implementation of recommended solutions. The study therefore provides a general checklist to guide policy direction, while advocating for policy-based researches and empirical studies in order to provide the data base for formulation of a sustainable national transport policy for Nigeria.

Guide to the economic regulation of the energy industries in the European Union

Energy Technology Data Exchange (ETDEWEB)

NONE

1998-12-01

This new addition to the series of OXERA Guides to Regulation provides an analysis of the electricity and gas sectors of each of the 15 EU member states, against the backdrop of the liberalisation of the electricity market and the anticipated liberalisation of the gas market. For each country, the guide provides details of: the industry and institutional structure; privatisation status; government policy; level of competition; licensing regimes; price and non-price regulation and; environmental policies. (Author)

Investigating compliance with SME-friendly procurement policy

OpenAIRE

Flynn, Anthony

2016-01-01

This study investigates compliance with SME-friendly policy in public procurement. Two research questions guide the investigation. The first is the extent to which policy is being complied with. The results, which are based on 349 public buyer survey responses, reveal compliance to be moderate; indicated by a mean score of 14.54 out of 22 on the compliance index. The second question concerns the impact of institutional forces on policy compliance. A predictive model informed by institutional ...

Progress in Y-00 physical cipher for Giga bit/sec optical data communications (intensity modulation method)

Science.gov (United States)

Hirota, Osamu; Futami, Fumio

2014-10-01

To guarantee a security of Cloud Computing System is urgent problem. Although there are several threats in a security problem, the most serious problem is cyber attack against an optical fiber transmission among data centers. In such a network, an encryption scheme on Layer 1(physical layer) with an ultimately strong security, a small delay, and a very high speed should be employed, because a basic optical link is operated at 10 Gbit/sec/wavelength. We have developed a quantum noise randomied stream cipher so called Yuen- 2000 encryption scheme (Y-00) during a decade. This type of cipher is a completely new type random cipher in which ciphertext for a legitimate receiver and eavesdropper are different. This is a condition to break the Shannon limit in theory of cryptography. In addition, this scheme has a good balance on a security, a speed and a cost performance. To realize such an encryption, several modulation methods are candidates such as phase-modulation, intensity-modulation, quadrature amplitude modulation, and so on. Northwestern university group demonstrated a phase modulation system (α=η) in 2003. In 2005, we reported a demonstration of 1 Gbit/sec system based on intensity modulation scheme(ISK-Y00), and gave a design method for quadratic amplitude modulation (QAM-Y00) in 2005 and 2010. An intensity modulation scheme promises a real application to a secure fiber communication of current data centers. This paper presents a progress in quantum noise randomized stream cipher based on ISK-Y00, integrating our theoretical and experimental achievements in the past and recent 100 Gbit/sec(10Gbit/sec × 10 wavelengths) experiment.

Dynamic Systems Modeling in Educational System Design & Policy

Science.gov (United States)

Groff, Jennifer Sterling

2013-01-01

Over the last several hundred years, local and national educational systems have evolved from relatively simple systems to incredibly complex, interdependent, policy-laden structures, to which many question their value, effectiveness, and direction they are headed. System Dynamics is a field of analysis used to guide policy and system design in…

Classification guide: Sochi 2014 Paralympic Winter Games

OpenAIRE

2014-01-01

The Sochi 2014 Paralympic Winter Games classification guide is designed to provide National Paralympic Committees (NPCs) and International Federations (IFs) with information about the classification policies and procedures that will apply to the Sochi 2014 Paralympic Winter Games.

Rockets: Educator's Guide with Activities in Science, Technology, Engineering and Mathematics

Science.gov (United States)

Shearer, Deborah A.; Vogt, Gregory L.

2008-01-01

This guide provides teachers and students many opportunities. Chapters within the guide present the history of rocketry, National Aeronautics and Space Administration's (NASA's) 21st Century Space Exploration Policy, rocketry principles, and practical rocketry. These topics lay the foundation for what follows--a wealth of dynamic rocket science…

Health promotion interventions and policies addressing excessive alcohol use: a systematic review of national and global evidence as a guide to health-care reform in China.

Science.gov (United States)

Li, Qing; Babor, Thomas F; Zeigler, Donald; Xuan, Ziming; Morisky, Donald; Hovell, Melbourne F; Nelson, Toben F; Shen, Weixing; Li, Bing

2015-01-01

Steady increases in alcohol consumption and related problems are likely to accompany China's rapid epidemiological transition and profit-based marketing activities. We reviewed research on health promotion interventions and policies to address excessive drinking and to guide health-care reform. We searched Chinese- and English-language databases and included 21 studies in China published between 1980 and 2013 that covered each policy area from the World Health Organization (WHO) Global Strategy to Reduce the Harmful Use of Alcohol. We evaluated and compared preventive interventions to the global alcohol literature for cross-national applicability. In contrast with hundreds of studies in the global literature, 11 of 12 studies from mainland China were published in Chinese; six of 10 in English were on taxation from Taiwan or Hong Kong. Most studies demonstrated effectiveness in reducing excessive drinking, and some reported the reduction of health problems. Seven were randomized controlled trials. Studies targeted schools, drink-driving, work-places, the health sector and taxation. China is the world's largest alcohol market, yet there has been little growth in alcohol policy research related to health promotion interventions over the past decade. Guided by a public health approach, the WHO Global Strategy and health reform experience in Russia, Australia, Mexico and the United States, China could improve its public health response through better coordination and implementation of surveillance and evidence-based research, and through programmatic and legal responses such as public health law research, screening and early intervention within health systems and the implementation of effective alcohol control strategies. © 2014 Society for the Study of Addiction.

Collection Development for the School Library Media Program: A Beginner's Guide

Science.gov (United States)

Kerby, Mona

2006-01-01

A valuable resource for new or experienced school librarians, "Collection Development for the School Library Media Program: A Beginner's Guide" is an easy-to-use guide to collection development. It provides practical and relevant information about collection development issues such as: the school users, policies, selection criteria and sources,…

Editor's Choice The Role of Economic Policy in Climate Change Adaptation

OpenAIRE

Kai A. Konrad; Marcel Thum

2014-01-01

This article assesses the role of the public sector in adaptation to climate change. We first offer a definition and categorization of climate change adaptation. We then consider the primary economic principles that can guide the assignment of adaptation tasks to either the private or the public sector, as well as those guiding assignment within the public sector itself. We find that the role of the state in adaptation policy is limited. We identify information policy, the provision of a suit...

Policies and Procedures for Foreign Exchange Agencies. First Edition.

Science.gov (United States)

Hartman, Donald D.

The guide details the policy of the Jefferson County (Alabama) Board of Education policy concerning international exchange of students (travel both to and from United States) in elementary and secondary grades. The first section specifies the standards by which the county will evaluate all international exchange agencies concerning structure,…

The Guide to Community Preventive Services and Disability Inclusion.

Science.gov (United States)

Hinton, Cynthia F; Kraus, Lewis E; Richards, T Anne; Fox, Michael H; Campbell, Vincent A

2017-12-01

Approximately 40 million people in the U.S. identify as having a serious disability, and people with disabilities experience many health disparities compared with the general population. The Guide to Community Preventive Services (The Community Guide) identifies evidence-based programs and policies recommended by the Community Preventive Services Task Force (Task Force) to promote health and prevent disease. The Community Guide was assessed to answer the questions: are Community Guide public health intervention recommendations applicable to people with disabilities, and are adaptations required? An assessment of 91 recommendations from The Community Guide was conducted for 15 health topics by qualitative analysis involving three data approaches: an integrative literature review (years 1980-2011), key informant interviews, and focus group discussion during 2011. Twenty-six recommended interventions would not need any adaptation to be of benefit to people with disabilities. Forty-one recommended interventions could benefit from adaptations in communication and technology; 33 could benefit from training adaptations; 31 from physical accessibility adaptations; and 16 could benefit from other adaptations, such as written policy changes and creation of peer support networks. Thirty-eight recommended interventions could benefit from one or more adaptations to enhance disability inclusion. As public health and healthcare systems implement Task Force recommendations, identifying and addressing barriers to full participation for people with disabilities is important so that interventions reach the entire population. With appropriate adaptations, implementation of recommendations from The Community Guide could be successfully expanded to address the needs of people with disabilities. Published by Elsevier Inc.

IEEE P1596, a scalable coherent interface for GigaByte/sec multiprocessor applications

International Nuclear Information System (INIS)

Gustavson, D.B.

1988-11-01

IEEE P1596, the Scalable Coherent Interface (formerly known as SuperBus) is based on experience gained during the development of Fastbus (IEEE 960), Futurebus (IEEE 896.1) and other modern 32-bit buses. SCI goals include a minimum bandwidth of 1 GByte/sec per processor; efficient support of a coherent distributed-cache image of shared memory; and support for segmentation, bus repeaters and general switched interconnections like Banyan, Omega, or full crossbar networks. To achieve these ambitious goals, SCI must sacrifice the immediate handshake characteristic of the present generation of buses in favor of a packet-like split-cycle protocol. Wire-ORs, broadcasts, and even ordinary passive bus structures are to be avoided. However, a lower performance (1 GByte/sec per backplane instead of per processor) implementation using a register insertion ring architecture on a passive ''backplane'' appears to be possible using the same interface as for the more costly switch networks. This paper presents a summary of current directions, and reports the status of the work in progress

Overproduction of a Model Sec- and Tat-Dependent Secretory Protein Elicits Different Cellular Responses in Streptomyces lividans.

Directory of Open Access Journals (Sweden)

Sonia Gullón

Full Text Available Streptomyces lividans is considered an efficient host for the secretory production of homologous and heterologous proteins. To identify possible bottlenecks in the protein production process, a comparative transcriptomic approach was adopted to study cellular responses during the overproduction of a Sec-dependent model protein (alpha-amylase and a Tat-dependent model protein (agarase in Streptomyces lividans. The overproduction of the model secretory proteins via the Sec or the Tat route in S. lividans does elicit a different major cell response in the bacterium. The stringent response is a bacterial response to nutrients' depletion, which naturally occurs at late times of the bacterial cell growth. While the induction of the stringent response at the exponential phase of growth may limit overall productivity in the case of the Tat route, the induction of that response does not take place in the case of the Sec route, which comparatively is an advantage in secretory protein production processes. Hence, this study identifies a potential major drawback in the secretory protein production process depending on the secretory route, and provides clues to improving S. lividans as a protein production host.

Ultra high tip speed (670.6 m/sec) fan stage with composite rotor: Aerodynamic and mechanical design

Science.gov (United States)

Halle, J. E.; Burger, G. D.; Dundas, R. E.

1977-01-01

A highly loaded, single-stage compressor having a tip speed of 670.6 m/sec was designed for the purpose of investigating very high tip speeds and high aerodynamic loadings to obtain high stage pressure ratios at acceptable levels of efficiency. The design pressure ratio is 2.8 at an adiabatic efficiency of 84.4%. Corrected design flow is 83.4 kg/sec; corrected design speed is 15,200 rpm; and rotor inlet tip diameter is 0.853 m. The rotor uses multiple-circular-arc airfoils from 0 to 15% span, precompression airfoils assuming single, strong oblique shocks from 21 to 43% span, and precompression airfoils assuming multiple oblique shocks from 52% span to the tip. Because of the high tip speeds, the rotor blades are designed to be fabricated of composite materials. Two composite materials were investigated: Courtaulds HTS graphite fiber in a Kerimid 601 polyimide matrix and the same fibers in a PMR polyimide matrix. In addition to providing a description of the aerodynamic and mechanical design of the 670.0 m/sec fan, discussion is presented of the results of structural tests of blades fabricated with both types of matrices.

Youth policy and participation: An analysis of pedagogical ideals in municipal youth policy in the Netherlands

NARCIS (Netherlands)

Timmerman, Greetje

Over the past two decades, in several Northern and Western European Union countries responsibility for general youth policy has been transferred from the central government to the local level of municipalities. In this transformation process the local authorities. guided by central government's

How can global conventions for biodiversity and ecosystem services guide local conservation actions?

NARCIS (Netherlands)

Geijzendorffer, Ilse R.; van Teeffelen, Astrid; Allison, Hilary; Braun, Daniela; Horgan, K.; Iturrate-Garcia, Maitane; Santos, Maria João; Pellissier, Loïc; Prieur-Richard, Anne-Helene; Quatrini, Simone; Sakai, Shoko; Zuppinger-Dingley, Debra

2017-01-01

With global science-policy conventions for biodiversity and ecosystem services in place, much effort goes into monitoring and reporting on the progress toward policy targets. As conservation actions happen locally, can such global monitoring and reporting efforts effectively guide conservation

Policy Matters: De/Re/Territorialising Spaces of Learning in Victorian Government Schools

Science.gov (United States)

Mulcahy, Dianne

2016-01-01

This article seeks to augment an emerging interest in education policy research in enactment theorising, to explicitly consider the role and contribution of materiality in this theorising. Guided by the notion of policy "matters," the article takes as its empirical context a major policy initiative, the Building the Education Revolution…

Solar Powering Your Community: A Guide for Local Governments; Second Edition

Energy Technology Data Exchange (ETDEWEB)

2011-01-01

DOE designed this guide "Solar Powering Your Community: A Guide for Local Governments" to assist local government officials and stakeholders in designing and implementing strategic local solar plans. The 2011 edition contains the most recent lessons and successes from the 25 Solar America Cities and other communities promoting solar energy. Because DOE recognizes that there is no one path to solar market development, this guide introduces a range of policy and program options that can help a community build a local solar infrastructure.

Smart Grid: Smart Customer Policy Needs

Energy Technology Data Exchange (ETDEWEB)

NONE

2011-07-01

In September 2010, the International Energy Agency (IEA) held a workshop on the regulatory, market and consumer policies necessary to ensure that smart grids are deployed with adequate consideration of their risks and benefits to all stakeholders. This was one of several workshops that brought together energy providers, network operators, technology developers, regulators, customers and government policy makers to discuss smart grid technology and policy. The Smart Grid - Smart Customer Policies workshop allowed stakeholders to: gain a perspective on key issues and barriers facing early deployment of smart grids; hear expert opinion on regulatory, consumer and market challenges to smart grids; discuss smart grid-smart customer policy priorities; and build consensus on the technology and policy ingredients needed for customer-friendly smart grid deployments. Drawing on workshop discussions, the following paper lays out a logical framework to maximise the benefits and minimise the risks that smart grids pose for customers. The paper also describes key policy research questions that will guide future IEA research on this topic.

AGRICULTURAL POLICIES AND COMPETITION IN WORLD AGRICULTURE

Directory of Open Access Journals (Sweden)

Raluca Duma

2011-04-01

Full Text Available Agricultural policies have had a guiding role inagriculture development and implicitly in their marketing. Usually they belongto each state and government and are issued in accordance with their specificclimate, social-economic and cultural background which includes food andgastronomic traditions. Agricultural policies have in view home and foreignmarket demand, as well as the socio-demographic, political and military contextat a certain point in the socio-economic development

THE CONTRIBUTION OF PUBLIC INTEREST RESEARCH TO TRANSPORTATION POLICY

OpenAIRE

Makoto ITOH

2003-01-01

Established in 1995 with the basic philosophy of serving as a bridge between research and practice, the Institute for Transport Policy Studies conducts activities in support of transportation policy research in the public interest. This paper aims to describe the contribution of public interest research to transportation policy as seen in the Institute's activities. Touching first on the context and events leading to its establishment, the paper then describes the Institute's guiding principl...

PCR múltiple para la detección de los genes sea, seb, sec, sed y see de Staphylococcus aureus: Caracterización de aislamientos de origen alimentario Multiplex PCR for the detection of sea, seb, sec, sed and see genes of Staphylococcus aureus: Characterization of isolates from food

Directory of Open Access Journals (Sweden)

E. A. Manfredi

2010-09-01

Full Text Available La presencia de Staphylococcus aureus en los alimentos representa un riesgo potencial para la salud pública; sus enterotoxinas son el principal factor de virulencia. La detección de las enterotoxinas de S. aureus puede realizarse por ELISA, aunque sólo es posible detectar el pool de enterotoxinas SEA, SEB, SEC, SED y SEE. Los objetivos del presente trabajo fueron optimizar dos técnicas de PCR múltiple para la detección de los genes sea, seb, sec, sed y see de S. aureus y caracterizar un conjunto de 115 aislamientos de Staphylococcus spp. asociados a intoxicaciones alimentarias provenientes de diferentes provincias de Argentina. La caracterización se realizó por pruebas bioquímicas, ELISA y PCR. Sesenta y ocho aislamientos (59,1% fueron positivos por ELISA, mientras que 61 (53% fueron positivos por PCR. De los aislamientos positivos por PCR, 34 (55,7% portaron el gen sea, 9 (14,8% el gen seb, 5 (8,1% el gen see, 4 (6,5% el gen sec, 6 (9,9% los genes sea y seb, 2 (3,3% los genes sea y sec, y 1 (1,7% los genes sea y sed. Este es el primer estudio de caracterización genotípica de aislamientos de S. aureus asociados con brotes de intoxicación alimentaria registrados en distintas provincias argentinas.The presence of Staphylococcus aureus in food represents a potential risk to public health, being its enterotoxins the major virulence factor. Enterotoxin detection can be determined by ELISA, but only for the pool of enterotoxins SEA, SEB, SEC, SED and SEE. The main aims of this study were to optimize two PCR techniques for detection of S. aureus sea, seb, sec, sed and see, and to characterize Staphylococcus spp. isolates associated with food intoxication. Two PCR techniques were optimized and 115 Staphylococcus spp. isolates from Ciudad Autónoma de Buenos Aires, and Buenos Aires, Córdoba, and Neuquén provinces were characterized. The characterization was performed by biochemical tests, ELISA and PCR. Sixty-eight isolates (59.1% were

Analyzing Crime and Crime Control: A Resource Guide. Economics-Political Science Series.

Science.gov (United States)

Butterfield, Ruth I.; And Others

This document, the fourth in a series of resource guides emphasizing economic-political analysis of contemporary public policies and issues, focuses on crime control. Designed as a three-week unit for secondary school students, the guide is presented in three sections. The introduction presents an economic and a political science framework for…

Iron metabolism mutant hbd mice have a deletion in Sec15l1, which has homology to a yeast gene for vesicle docking.

Science.gov (United States)

White, Robert A; Boydston, Leigh A; Brookshier, Terri R; McNulty, Steven G; Nsumu, Ndona N; Brewer, Brandon P; Blackmore, Krista

2005-12-01

Defects in iron absorption and utilization lead to iron deficiency and anemia. While iron transport by transferrin receptor-mediated endocytosis is well understood, it is not completely clear how iron is transported from the endosome to the mitochondria where heme is synthesized. We undertook a positional cloning project to identify the causative mutation for the hemoglobin-deficit (hbd) mouse mutant, which suffers from a microcytic, hypochromic anemia apparently due to defective iron transport in the endocytosis cycle. As shown by previous studies, reticulocyte iron accumulation in homozygous hbd/hbd mice is deficient despite normal binding of transferrin to its receptor and normal transferrin uptake in the cell. We have identified a strong candidate gene for hbd, Sec15l1, a homologue to yeast SEC15, which encodes a key protein in vesicle docking. The hbd mice have an exon deletion in Sec15l1, which is the first known mutation of a SEC gene homologue in mammals.

Environmental Compliance Guide

International Nuclear Information System (INIS)

1981-02-01

The Guide is intended to assist Department of Energy personnel by providing information on the NEPA process, the processes of other environmental statutes that bear on the NEPA process, the timing relationships between the NEPA process and these other processes, as well as timing relationships between the NEPA process and the development process for policies, programs, and projects. This information should be helpful not only in formulating environmental compliance plans but also in achieving compliance with NEPA and various other environmental statutes. The Guide is divided into three parts with related appendices: Part I provides guidance for developing environmental compliance plans for DOE actions; Part II is devoted to NEPA with detailed flowcharts depicting the compliance procedures required by CEQ regulations and Department of Energy NEPA Guidelines; and Part III contains a series of flowcharts for other Federal environmental requirements that may apply to DOE projects

Environmental Compliance Guide

Energy Technology Data Exchange (ETDEWEB)

None

1981-02-01

The Guide is intended to assist Department of Energy personnel by providing information on the NEPA process, the processes of other environmental statutes that bear on the NEPA process, the timing relationships between the NEPA process and these other processes, as well as timing relationships between the NEPA process and the development process for policies, programs, and projects. This information should be helpful not only in formulating environmental compliance plans but also in achieving compliance with NEPA and various other environmental statutes. The Guide is divided into three parts with related appendices: Part I provides guidance for developing environmental compliance plans for DOE actions; Part II is devoted to NEPA with detailed flowcharts depicting the compliance procedures required by CEQ regulations and Department of Energy NEPA Guidelines; and Part III contains a series of flowcharts for other Federal environmental requirements that may apply to DOE projects.

Year 2000 (Y2K) computer compliance guide; guidance for FDA personnel. Food and Drug Administration. Notice.

Science.gov (United States)

1999-05-14

The Food and Drug Administration (FDA) is announcing the availability of a new compliance policy guide (CPG) entitled "Year 2000 (Y2K) Computer Compliance" (section 160-800). This guidance document represents the agency's current thinking on the manufacturing and distribution of domestic and imported products regulated by FDA using computer systems that may not perform properly before, or during, the transition to the year 2000 (Y2K). The text of the CPG is included in this notice. This compliance guidance document is an update to the Compliance Policy Guides Manual (August 1996 edition). It is a new CPG, and it will be included in the next printing of the Compliance Policy Guides Manual. This CPG is intended for FDA personnel, and it is available electronically to the public.

Challenges for decommissioning policies

International Nuclear Information System (INIS)

Riotte, H.

2007-01-01

In the coming years, OECD member countries will be increasingly faced with the need to make appropriate provisions, in terms of policy, finance and management, for all aspects of decommissioning. Decommissioning requires regulatory approval and oversight, the directions of which are guided by national policy. In several instances, governments have only recently begun to address their approaches to decommissioning policy and regulation in national legislation, and international overviews of such approaches, which may eventually lead to international harmonization, are only now beginning to emerge. In parallel, policy and regulation have been evolving and a broadened competence has developed in relevant regulatory authorities. The challenge lying ahead is to establish a framework that will allow for the growth of nuclear industrial activities in competitive, globalized markets, while maintaining and assuring the safety of decommissioning for the public and for workers. Within this context, institutional arrangements, stakeholder issues, costs and funding, waste management and policies for release from regulatory control, as well as the availability of technologies and skills, need to be reviewed. (author)

Beyond Sputnik U.S. science policy in the twenty-first century

CERN Document Server

Neal, Homer A; McCormick, Jennifer

2008-01-01

Science and technology are responsible for almost every advance in our modern quality of life. Yet science isn't just about laboratories, telescopes and particle accelerators. Public policy exerts a huge impact on how the scientific community conducts its work. Beyond Sputnik is a comprehensive survey of the field for use as an introductory textbook in courses and a reference guide for legislators, scientists, journalists, and advocates seeking to understand the science policy-making process. Detailed case studies---on topics from cloning and stem cell research to homeland security and science education---offer readers the opportunity to study real instances of policymaking at work. Authors and experts Homer A. Neal, Tobin L. Smith, and Jennifer B. McCormick propose practical ways to implement sound public policy in science and technology and highlight how these policies will guide the results of scientific discovery for years to come.

The role of organizational culture in policy mobilities – the case of South Korean climate change adaptation policies

Directory of Open Access Journals (Sweden)

S. Schäfer

2017-07-01

Full Text Available The conceptualization of policies as mobile and mutable knowledge is the key feature of the recent debate on policy mobilities. Policy mobility studies have focused on the movement and translation of policies as well as on the impact of mobile policies on policy-making processes and governed spaces. Given that policy mobilities have mainly been examined in comparable institutional contexts, the current debate has neglected the role of organizational culture in the translation of policies. Organizational culture is understood as a set of shared assumptions that guide what happens in organizations by defining appropriate practices of policy making. The case study, South Korean adaptation policy, illustrates that organizational culture has a significant impact on the translation of mobile adaptation policy. Besides the claim to consider organizational culture more prominently in the field of policy mobility studies, this paper illustrates the translation process of adaptation policy in the South Korean political system. The practices in South Korean political institutions dealing with climate change adaptation are highly characterized by the avoidance of risks. The propensity to avoid risks leads policy makers to focus on technical solutions to climate change adaptation and to neglect the participation of civil society.

77 FR 55183 - Effects of Foreign Policy-Based Export Controls

Science.gov (United States)

2012-09-07

...); Communication intercepting devices, software and technology (Sec. 742.13); Nuclear propulsion (Sec. 744.5... International Terrorism (Sec. Sec. 742.8, 742.9, 742.10, 742.19, 746.2, 746.4, 746.7, and 746.9); Certain...

78 FR 54623 - Effects of Foreign Policy-Based Export Controls

Science.gov (United States)

2013-09-05

...); Communication intercepting devices, software and technology (Sec. 742.13); Nuclear propulsion (Sec. 744.5... International Terrorism (Sec. Sec. 742.8, 742.9, 742.10, 742.19, 746.2, 746.4, 746.7, and 746.9); Certain...

American Evaluation Association: Guiding Principles for Evaluators

Science.gov (United States)

American Journal of Evaluation, 2009

2009-01-01

The American Evaluation Association (AEA) strives to promote ethical practice in the evaluation of programs, products, personnel, and policy. This article presents the list of principles which AEA developed to guide evaluators in their professional practice. These principles are: (1) Systematic Inquiry; (2) Competence; (3) Integrity/Honesty; (4)…

Policy for Promotion of Women's Mental Health: Insight from Analysis of Policy on Postnatal Depression in Mexico.

Science.gov (United States)

Place, Jean Marie S; Billings, Deborah L; Frongillo, Edward A; Blake, Christine E; Mann, Joshua R; deCastro, Filipa

2016-03-01

This article critically examines federal, state and facility-level policies, as well as clinical practice guidelines regarding postnatal depression in Mexico. Thirteen documents including national health plans, national action plans, federal and state laws and regulations, clinical practice guidelines, and public-sector healthcare facility policies were collected and evaluated according to whether they included a statement of intent and/or actions related to the care of women at risk for or experiencing postnatal depression. While postnatal depression is included in several policies in Mexico, it is not addressed in ways that guide actions to manage postnatal depression. Specific direction on postnatal depression in policies would bridge a gap in maternal mental healthcare given that medication, treatment, and timing of interventions is unique in the postpartum context.

Development of National Technology Audit Policy

Directory of Open Access Journals (Sweden)

Subiyanto Subiyanto

2017-07-01

Full Text Available The Laws have mandated implementation of technology audit, nevertheless such implementation needs an additional policy that is more technical. The concept of national audit technology policy shall make technology audit as a tool to ensure the benefit of technology application for society and technology advance for nation independency. This article discusses on technology audit policy concept especially infrastructure requirement, with emphasis on regulation, implementation tools, and related institution. The development of technology audit policy for national interest requires provision of mandatory audit implementation, accompanied by tools for developing technology auditor’s competence and technology audit institutional’s mechanism. To guide technology auditor’s competence, concept of national audit technology policy shall classify object of technology audit into product technology, production technology, and management of technology, accompanied by related parameters of technology performance evaluation.

The Design of NetSecLab: A Small Competition-Based Network Security Lab

Science.gov (United States)

Lee, C. P.; Uluagac, A. S.; Fairbanks, K. D.; Copeland, J. A.

2011-01-01

This paper describes a competition-style of exercise to teach system and network security and to reinforce themes taught in class. The exercise, called NetSecLab, is conducted on a closed network with student-formed teams, each with their own Linux system to defend and from which to launch attacks. Students are expected to learn how to: 1) install…

Using the Theory of Planned Behavior to Guide Focus Group Development of Messages Aimed at Increasing Compliance With a Tobacco-Free Policy.

Science.gov (United States)

Record, Rachael A; Harrington, Nancy G; Helme, Donald W; Savage, Matthew W

2018-01-01

This study details the persuasive message development for a theory-based campaign designed to increase compliance with a university's tobacco-free policy. The theory of planned behavior (TPB) guided message design and evaluation for focus group-tested messages that were adapted to the context of complying with a tobacco-free policy. The study was conducted at a university located in the tobacco belt. Undergraduate focus group participants (n = 65) were mostly male (69%), white (82%), and freshman (62%) who smoked at least 1 cigarette in the last 30 days; on-campus smoking percentages were never/rare (60%), occasionally (23%), and often/frequently (16%). Data analysis used a theoretical thematic approach to identify how the TPB constructs related to perceptions of message effectiveness. Participants responded favorably to attitudinal strategies about health, respect, and university figures; they rejected approaches they considered juvenile and offensive. They also discussed the impact of noncompliance and avoiding overgeneralized statements for addressing subjective norms, suggesting shortening text, adjusting picture location, and emphasizing the importance of compliance to increase perceptions of behavioral control. Applying theory to preexisting messages is challenging. The design approach in this study is an evidence-based strategy that can be used as a universal process for message adaptation. Results offer health promotion suggestions for designing messages aimed at improving undergraduate smokers' willingness to comply with tobacco-free campus policies.

Finding electronic information for health policy advocacy: a guide to improving search results.

Science.gov (United States)

Olsan, Tobie H; Bianchi, Carolanne; White, Pamela; Glessner, Theresa; Mapstone, Pamela L

2011-12-01

The success of advanced practice registered nurses' (APRNs') health policy advocacy depends on staying well informed about key issues. Searching for high-quality health policy information, however, can be frustrating and time consuming. Busy clinicians need strategies and tips to reduce information overload and to access synthesized research for evidence-based health policy. This article therefore offers APRNs practical guidelines and resources for searching electronic health policy information. Scholarly databases and Internet sites. Electronic health policy information is generated by a wide variety of public and private organizations and disseminated in hundreds of journals and Web pages. Specialty search tools are needed to retrieve the unindexed gray literature, which includes government documents, agency reports, fact sheets, standards, and statistics not produced by commercial publishers. Further, Internet users need to examine search results with a critical eye for information quality. Expertise in searching electronic health policy information is a prerequisite for developing APRNs' leadership in political arenas to influence health policy and the delivery of healthcare services. ©2011 The Author(s) Journal compilation ©2011 American Academy of Nurse Practitioners.

Crystallization and preliminary X-ray diffraction analysis of phospholipid-bound Sfh1p, a member of the Saccharomyces cerevisiae Sec14p-like phosphatidylinositol transfer protein family

International Nuclear Information System (INIS)

Schaaf, Gabriel; Betts, Laurie; Garrett, Teresa A.; Raetz, Christian R. H.; Bankaitis, Vytas A.

2006-01-01

Yeast Sfh1p, a close homolog of the Sec14p phosphatidylinositol transfer protein, was crystallized in the absence of detergent. X-ray data have been collected to 2.5 Å. Sec14p is the major phosphatidylinositol (PtdIns)/phosphatidylcholine (PtdCho) transfer protein in the budding yeast Saccharomyces cerevisiae and is the founding member of a large eukaryotic protein superfamily. This protein catalyzes the exchange of either PtdIns or PtdCho between membrane bilayers in vitro and this exchange reaction requires no external input of energy or of other protein cofactors. Despite the previous elucidation of the crystal structure of a detergent-bound form of Sec14p, the conformational changes that accompany the phospholipid-exchange reaction remain undefined. Moreover, a structural appreciation of how Sec14p or its homologs bind their various phospholipid substrates remains elusive. Here, the purification and crystallization of yeast Sfh1p, the protein most closely related to Sec14p, are reported. A combination of electrospray ionization mass-spectrometry and collision-induced decomposition mass-spectrometry methods indicate that recombinant Sfh1p loads predominantly with phosphatidylethanolamine. Unlike phospholipid-bound forms of Sec14p, this form of Sfh1p crystallizes readily in the absence of detergent. Sfh1p crystals diffract to 2.5 Å and belong to the orthorhombic primitive space group P2 1 2 1 2 1 , with unit-cell parameters a = 49.40, b = 71.55, c = 98.21 Å, α = β = γ = 90°. One Sfh1p molecule is present in the asymmetric unit (V M = 2.5 Å 3 Da −1 ; V s = 50%). Crystallization of a phospholipid-bound Sec14p-like protein is a critical first step in obtaining the first high-resolution picture of how proteins of the Sec14p superfamily bind their phospholipid ligands. This information will significantly extend our current understanding of how Sec14p-like proteins catalyze phospholipid exchange

Tracking and trailing. A travel guide for the energy transition

International Nuclear Information System (INIS)

Hekkenberg, M.; Londo, M.

2011-09-01

Our energy system, which is one of the pillars of the Dutch society, will probably be subjected to drastic changes in the coming decades. It will become a difficult and painful process at times. Policy makers have the task of directing these changes with a clear view on opportunities and threats. This guide aims to offer Dutch policy makers some strategic insights and tools. [nl

46 CFR Sec. 17 - Performance of work resulting from damage sustained while undergoing repairs.

Science.gov (United States)

2010-10-01

... made a part of and place on each job order issued for the performance of work discussed in this section... 46 Shipping 8 2010-10-01 2010-10-01 false Performance of work resulting from damage sustained... SHIPPING AUTHORITY MASTER LUMP SUM REPAIR CONTRACT-NSA-LUMPSUMREP Sec. 17 Performance of work resulting...

14 CFR 1232.102 - Policy.

Science.gov (United States)

2010-01-01

... Health (NIH) Publication No. 85-23 (Rev. 1985), “Guide for the Care and Use of Laboratory Animals” (the... Public Health Service (PHS) Policy on Humane Care and Use of Laboratory Animals (hereinafter referred to... Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION CARE AND USE OF ANIMALS IN THE CONDUCT OF...

Windows® Group Policy Administrators Pocket Consultant

CERN Document Server

Stanek, William

2009-01-01

Portable and precise, this pocket-sized guide delivers ready answers for the day-to-day administration of Group Policy. Zero in on core support and maintenance tasks using quick-reference tables, instructions, and lists. You'll get the focused information you need to solve problems and get the job done-whether at your desk or in the field! Get fast facts to: Configure Local GPOs and Active Directory®-based GPOsManage policy preferences and settingsModel policy changes through the consoleMigrate and maintain the SYSVOLDiagnose and troubleshoot replication issuesKnow when to enforce, block,

Accounting for the distributional impacts of policy in the green accounts

NARCIS (Netherlands)

Horan, R.D.; Hrubovcak, J.; Shortle, J.S.; Bulte, E.H.

2000-01-01

Green income accounting models are designed to appropriately value changes in a country's natural resource (natural capital) base. However, green NNP is useful as a guide for domestic and international policy only to the extent that it accurately reflects the economic goals and policy options of

Energy policy of France

International Nuclear Information System (INIS)

Revol, H.

2001-01-01

In November 1997, the French senate decided the creation of an inquiry commission in order to start up a study about the future of the French energy policy. The commission has interviewed the overall actors of the energy policy: ministers, heads of energy companies, higher officials, syndicates, consumer and environment protection associations, scientists and economists. The inquiry has been extended to other countries of the European community, and also to China, Japan, the USA and Canada. Despite various economical contexts and resources, all these countries have developed energy policies which aim at ensuring an energy independence and at supplying energy at the best price for a better economic competitiveness. This report presents first the French experience and the evolution of the French energy policy during the last 50 years with respect to the economical and political constraints encountered. The second part is a reflection about the principles that will guide the French energy policy in the context of deregulation of the European energy market and of the environmental constraints imposed by the Kyoto summit. Detailed proposals for the increase of the French energy independence are presented in conclusion of the report. (J.S.)

National environmental policy act disclosure of air quality impacts for prescribed fire projects in national forests in the Pacific Southwest Region

Science.gov (United States)

Suraj Ahuja; Laurie Perrot

2008-01-01

A key purpose of the National Environmental Policy Act (NEPA) is to “promote effortswhich will prevent or eliminate damage to the environment and biosphere and stimulate thehealth and welfare of man” (NEPA, Sec 2). The Council on Environmental Quality states “theNEPA process is intended to help public officials make decisions that...

Resource Guide for Crisis Management in Schools.

Science.gov (United States)

LaPointe, Richard T.; And Others

A crisis can occur at any time, whether or not a school's staff plans for it. This resource guide is a compilation of user-friendly examples of policies, procedures, guidelines, checklists, and forms to help Virginia schools develop and implement a systematic crisis-management plan. Chapter 1 provides an introductory overview of the essential…

In vitro expression of Sec-dependent pathway and type 4B secretion system in Piscirickettsia salmonis.

Science.gov (United States)

Cortés, Marcos; Sánchez, Patricio; Ruiz, Pamela; Haro, Ronie; Sáez, Jerson; Sánchez, Fabián; Hernández, Mauricio; Oliver, Cristian; Yáñez, Alejandro J

2017-09-01

Piscirickettsia salmonis is an intracellular bacterium and the causative agent of Piscirickettsiosis, a disease responsible for considerable mortalities in the Chilean salmon farming industry. Currently, P. salmonis protein translocation across the membrane and the mechanisms by which virulence factors are delivered to host cells are poorly understood. However, it is known that Gram-negative bacteria possess several mechanisms that transport proteins to the periplasmic and extracellular compartments. The aim of this study was to evaluate the expressional changes of several genes in the P. salmonis Sec-dependent pathway and type 4B secretion system during in vitro infection. Genes homologous and the main proteins belonging to Sec-dependent pathway and Type 4 Dot/Icm secretion system were found in the genome and proteome of P. salmonis AUSTRAL-005 strain. Additionally, several genes of these protein transport mechanisms were overexpressed during in vitro P. salmonis infection in SHK-1 cell line. The obtained data indicate that the Sec-dependent pathway and Type 4B secretion system are biologically active during P. salmonis infection. These mechanisms could contribute to the recycling of proteins into the inner and outer bacterial membrane and in translocate virulence factors to infected cell, which would favor the structural integrity and virulence of this bacterium. Copyright © 2017 Elsevier Ltd. All rights reserved.

Reassessing Occupational Licensing Of Tour Guides (Opinion Piece

Directory of Open Access Journals (Sweden)

Amir SHANI

2017-06-01

Full Text Available It is conventionally held that to protect tourists from incompetent and/or unscrupulous tour guides, governments should require guides to be licensed in order to legally practice their profession. Despite the implementation of such regulatory statutes in many countries, it is argued in this opinion paper that the severe drawbacks of licensing demands should be re-evaluated by both policy-makers and tourism scholars. The licensing of guides is not only an ineffective means of quality assurance, with negative consequences for many of those involved, but it also undermines the ethical foundations of a free society. Furthermore, licensing is an archaic practice for ensuring standardization among the members of a profession in a way that is no longer suitable for addressing the challenges of the tourism industry in the 21st century, in which a wide variety of specialized and innovative guided tours are offered to tourists. Although this commentary presents a firm stand against the compulsory licensing of tour guides, it should be seen as an invitation for open discussion among tourism researchers regarding the necessity of licensing tour guides in particular, and of government tourism regulation in general. Moreover, further research is needed to clarify key points on the issue of the professional licensing of tour guides.

GreyGuide Portal and Repositories "Sharing knowledge as early as possible"

OpenAIRE

Biagioni, Stefania; Carlesi, Carlo; Barsotti, Alessia; Pardini, Andrea

2017-01-01

The GreyGuide - Repository and Guide to Good Practices and Resources in Grey Literature was launched in 2013 as a collaborative effort between GreyNet International and ISTI-CNR. It aims at ?. Offering information professionals, practitioners, and students common ground for good practices and resources in grey literature; ?. Providing support for all stakeholders working on Grey Literature related research issues; ?. Being consistent with recommendations made in the Pisa Declaration on Policy...

Preparticipation Screening of Athletic Officials: SEC Football Referees at Risk.

Science.gov (United States)

Turner, John L; Walters, Rod; Leski, Mark J; Saywell, Robert M; Wooldridge, J Scott

2003-03-01

Although preparticipation screening for athletes is commonplace, few studies have addressed the issue for those officiating at games. To review current data on physiologic stress on sports officials, to obtain prevalence data on health parameters for football officials, and to determine the outcomes when screening criteria are applied in preseason exams. A protocol was established using health history questionnaires and physical exams with laboratory screening to assess the health of all football officials working in the Southeastern Conference (SEC) from 1997 to 2000. The main outcome measure was the prevalence of cardiac risk factors as determined by American College of Sports Medicine guidelines. Initial screening of 102 football officials revealed that 10.1% of SEC referees had elevated systolic blood pressure, 13.9% had elevated diastolic blood pressure, and 3.8% had resting tachycardia. Average body mass index (BMI) was 28.6 kg/m2, with 87.3% having a BMI that exceeded 25 (overweight). About one-third (31.6%) had a BMI greater than 30 (obese). Total fasting cholesterol exceeded 200 mg/dL in 44.2%, HDL levels were below 35 mg/dL in 34.3%, and LDL levels were above 120 mg/dL in 62.3%. Compared with age-adjusted national data, there were more overweight and more obese officials, but they had lower systolic and diastolic blood pressures and lower mean total cholesterol levels. Using the Framingham Study prediction model to estimate coronary heart disease (CHD) risk, analysis revealed that referees had a lower risk than the national 10-year CHD risk but a higher risk compared with that of the low-risk population. These data reveal a greater need for graded exercise testing. The higher rates of obesity among officials will promote further screening for CHD risk factors.

Computational Aerodynamic Simulations of an 840 ft/sec Tip Speed Advanced Ducted Propulsor Fan System Model for Acoustic Methods Assessment and Development

Science.gov (United States)

Tweedt, Daniel L.

2014-01-01

Computational Aerodynamic simulations of an 840 ft/sec tip speed, Advanced Ducted Propulsor fan system were performed at five different operating points on the fan operating line, in order to provide detailed internal flow field information for use with fan acoustic prediction methods presently being developed, assessed and validated. The fan system is a sub-scale, lownoise research fan/nacelle model that has undergone extensive experimental testing in the 9- by 15- foot Low Speed Wind Tunnel at the NASA Glenn Research Center, resulting in quality, detailed aerodynamic and acoustic measurement data. Details of the fan geometry, the computational fluid dynamics methods, the computational grids, and various computational parameters relevant to the numerical simulations are discussed. Flow field results for three of the five operating conditions simulated are presented in order to provide a representative look at the computed solutions. Each of the five fan aerodynamic simulations involved the entire fan system, excluding a long core duct section downstream of the core inlet guide vane. As a result, only fan rotational speed and system bypass ratio, set by specifying static pressure downstream of the core inlet guide vane row, were adjusted in order to set the fan operating point, leading to operating points that lie on a fan operating line and making mass flow rate a fully dependent parameter. The resulting mass flow rates are in good agreement with measurement values. The computed blade row flow fields for all five fan operating points are, in general, aerodynamically healthy. Rotor blade and fan exit guide vane flow characteristics are good, including incidence and deviation angles, chordwise static pressure distributions, blade surface boundary layers, secondary flow structures, and blade wakes. Examination of the computed flow fields reveals no excessive boundary layer separations or related secondary-flow problems. A few spanwise comparisons between

Menu Planning Guide for School Food Service. Revised.

Science.gov (United States)

VanEgmont-Pannell, Dorothy; And Others

This menu planning guide for school lunches and breakfasts contains: (1) lunch requirements, recommendations, and policies; (2) the basics of menu planning; (3) how to vary portions for various age/grade groups; (4) planning breakfasts; (5) merchandising school lunches and breakfasts; and (6) nutrition education and menu planning; Appendixes…

An energy policy for Europe

International Nuclear Information System (INIS)

2007-01-01

This document takes stock on the future energy policy of Europe. It discusses successively the challenges, the sustainability, the security of supply, the competitiveness, a strategic objective to guide europe energy policy, the action plan, the internal energy market, the solidarity between member states and security of supply for oil gas and electricity, a long term commitment to greenhouse gases reduction and the EU emissions trading System, the ambitious program of energy efficiency measures at Community national local and international level, a longer term target for renewable energy, a european strategic energy technology plan, a turn towards a low CO 2 fossil fuel future, the future of Nuclear, an international energy policy that actively pursues europe interests, the effective monitoring and reporting and how taking work forwards. (A.L.B.)

Policies of transnational Moroccan television station

Directory of Open Access Journals (Sweden)

Fathallah DAGHMI

2011-01-01

Full Text Available This work analyses the different televisions stations accessible to Moroccans living outside the country (Diaspora. It is particularly concerned with the discourse and representation of the managers of the stations. The objective is to understand the media available and the political and economic policies that guide them.

Connecting Children to the Future: A Telecommunications Policy Guide for Child Advocates.

Science.gov (United States)

Center for Media Education, Washington, DC.

New digital technologies and the rapid growth of the Internet are restructuring communications systems and transforming education and the economy. Noting that many of the resulting telecommunications policies will be made at the state level, this publication provides guidelines for child advocates to influence state policy regarding children's use…

Keggin type inorganic-organic hybrid material containing Mn(II) monosubstituted phosphotungstate and S-(+)-sec-butyl amine: Synthesis and characterization

Energy Technology Data Exchange (ETDEWEB)

Patel, Ketan [Chemistry Department, Faculty of Science, M.S. University of Baroda, Vadodara 390 002 (India); Patel, Anjali, E-mail: aupatel_chem@yahoo.com [Chemistry Department, Faculty of Science, M.S. University of Baroda, Vadodara 390 002 (India)

2012-02-15

Graphical abstract: A new organic-inorganic hybrid material containing Keggin type manganese substituted phosphotungstate and S-(+)-sec-butyl amine was synthesized and systematically characterized. Highlights: Black-Right-Pointing-Pointer New hybrid material comprising Mn substituted phosphotungstate (PW{sub 11}Mn) and S-(+)-sec-butyl amine (SBA) was synthesized. Black-Right-Pointing-Pointer The spectral studies reveal the attachment of SBA to the PW{sub 11}Mn without any distortion of structure. Black-Right-Pointing-Pointer The synthesized material comprises chirality. Black-Right-Pointing-Pointer The synthesized hybrid material can be used as a heterogeneous catalyst for carrying out asymmetric synthesis. -- Abstract: A new inorganic-organic POM-based hybrid material comprising Keggin type mono manganese substituted phosphotungstate and enantiopure S-(+)-sec-butyl amine was synthesized in an aqueous media by simple ligand substitution method. The synthesized hybrid material was systematically characterized in solid as well as solution by various physicochemical techniques such as elemental analysis, TGA, UV-vis, FT-IR, ESR and multinuclear solution NMR ({sup 31}P, {sup 1}H, {sup 13}C). The presence of chirality in the synthesized material was confirmed by CD spectroscopy and polarimeter. The above study reveals the attachment of S-(+)-sec-butyl amine to Keggin type mono manganese substituted phosphotungstate through N {yields} Mn bond. It also indicates the retainment of Keggin unit and presence of chirality in the synthesized material. An attempt was made to use the synthesized material as a heterogeneous catalyst for carrying out aerobic asymmetric oxidation of styrene using molecular oxygen. The catalyst shows the potential of being used as a stable recyclable catalytic material after simple regeneration without significant loss in conversion.

Working with Indian Tribal Nations. A guide for DOE employees

Energy Technology Data Exchange (ETDEWEB)

None

2000-12-31

U.S. Department of Energy (DOE) employees and contractors frequently work with Indian tribes or nations as part of their jobs. The purpose of this guide is to help DOE employees and contractors initiate contact with tribes and build effective relationships. DOE maintains a unique government-to government relationship with tribal nations. This guide presents an overview of the history of the relationship between the tribes and the Federal government, as well as the laws and Executive Orders that define that relationship. The guide discusses the Federal government’s trust responsibility to the tribes, tribal treaty rights, and the Department of Energy’s American Indian policy. The guide also discusses important cultural differences that could lead to communication problems if not understood and provides examples of potential cultural misunderstandings. In particular the guide discusses tribal environmental beliefs that shape tribal responses to DOE actions. The guide also provides pointers on tribal etiquette during meetings and cultural ceremonies and when visiting tribal reservations. Appendix 1 gives examples of the tribal nations with whom DOE currently has Memoranda of Understanding. While this guide provides an introduction and overview of tribal relations for DOE staff and contractors, DOE has also designated Tribal Issues Points of Contacts at each of its facilities. A list of these Points of Contact for all DOE facilities is provided in Appendix 2. DOE staff and contractors should consult with the appropriate tribal representatives at their site before initiating contact with a tribal nation, because many tribes have rules and procedures that must be complied with before DOE staff or contractors may go on tribal lands or conduct interviews with tribal members. Appendix 3 is the complete DOE American Indian Policy. Appendices 4-6 are Executive Orders that govern the relationship of all federal agencies with tribal nations. DOE employees and staff are

The Health Equity and Effectiveness of Policy Options to Reduce Dietary Salt Intake in England: Policy Forecast.

Directory of Open Access Journals (Sweden)

Duncan O S Gillespie

Full Text Available Public health action to reduce dietary salt intake has driven substantial reductions in coronary heart disease (CHD over the past decade, but avoidable socio-economic differentials remain. We therefore forecast how further intervention to reduce dietary salt intake might affect the overall level and inequality of CHD mortality.We considered English adults, with socio-economic circumstances (SEC stratified by quintiles of the Index of Multiple Deprivation. We used IMPACTSEC, a validated CHD policy model, to link policy implementation to salt intake, systolic blood pressure and CHD mortality. We forecast the effects of mandatory and voluntary product reformulation, nutrition labelling and social marketing (e.g., health promotion, education. To inform our forecasts, we elicited experts' predictions on further policy implementation up to 2020. We then modelled the effects on CHD mortality up to 2025 and simultaneously assessed the socio-economic differentials of effect.Mandatory reformulation might prevent or postpone 4,500 (2,900-6,100 CHD deaths in total, with the effect greater by 500 (300-700 deaths or 85% in the most deprived than in the most affluent. Further voluntary reformulation was predicted to be less effective and inequality-reducing, preventing or postponing 1,500 (200-5,000 CHD deaths in total, with the effect greater by 100 (-100-600 deaths or 49% in the most deprived than in the most affluent. Further social marketing and improvements to labelling might each prevent or postpone 400-500 CHD deaths, but minimally affect inequality.Mandatory engagement with industry to limit salt in processed-foods appears a promising and inequality-reducing option. For other policy options, our expert-driven forecast warns that future policy implementation might reach more deprived individuals less well, limiting inequality reduction. We therefore encourage planners to prioritise equity.

76 FR 54426 - Effects of Foreign Policy-Based Export Controls

Science.gov (United States)

2011-09-01

...); Communication intercepting devices, software and technology (Sec. 742.13); Embargoed countries (part 746); Countries designated as supporters of acts of international terrorism (Sec. Sec. 742.8, 742.9, 742.10, 742...

75 FR 54540 - Effects of Foreign Policy-Based Export Controls

Science.gov (United States)

2010-09-08

...); communication intercepting devices, software and technology (Sec. 742.13); embargoed countries (part 746); countries designated as supporters of acts of international terrorism (Sec. Sec. 742.8, 742.9, 742.10, 742...

Policy Pathways: Energy Performance Certification of Buildings

Energy Technology Data Exchange (ETDEWEB)

NONE

2010-07-01

Improving energy efficiency is one of the most effective measures to address energy security, climate change and economic objectives. The Policy Pathways series can help countries capture this potential by assisting with the implementation of the 25 energy efficiency policy recommendations that were published by the International Energy Agency (IEA) in 2008. This policy pathway on energy performance certification of buildings is the second in the series. It aims to provide a 'how-to' guide to policy makers and relevant stakeholders on the essential elements in implementing energy performance certification of buildings programmes. Energy performance certification of buildings is a way to rate the energy efficiency of individual buildings -- whether they be residential, commercial or public. It is a key policy instrument that can assist governments in reducing energy consumption in buildings. This policy pathway showcases experiences from countries around the world to show examples of good practice and delivers a pathway of ten critical steps to implement energy performance certification of buildings programmes.

Moving Forward with School Nutrition Policies: A Case Study of Policy Adherence in Nova Scotia.

Science.gov (United States)

McIsaac, Jessie-Lee D; Shearer, Cindy L; Veugelers, Paul J; Kirk, Sara F L

2015-12-01

Many Canadian school jurisdictions have developed nutrition policies to promote health and improve the nutritional status of children, but research is needed to clarify adherence, guide practice-related decisions, and move policy action forward. The purpose of this research was to evaluate policy adherence with a review of online lunch menus of elementary schools in Nova Scotia (NS) while also providing transferable evidence for other jurisdictions. School menus in NS were scanned and a list of commonly offered items were categorized, according to minimum, moderate, or maximum nutrition categories in the NS policy. The results of the menu review showed variability in policy adherence that depended on food preparation practices by schools. Although further research is needed to clarify preparation practices, the previously reported challenges of healthy food preparations (e.g., cost, social norms) suggest that many schools in NS are likely not able to use these healthy preparations, signifying potential noncompliance to the policy. Leadership and partnerships are needed among researchers, policy makers, and nutrition practitioners to address the complexity of issues related to food marketing and social norms that influence school food environments to inspire a culture where healthy and nutritious food is available and accessible to children.

Solar Powering Your Community: A Guide for Local Governments (Book)

Energy Technology Data Exchange (ETDEWEB)

None

2011-01-01

DOE designed this guide—Solar Powering Your Community: A Guide for Local Governments—to assist local government officials and stakeholders in designing and implementing strategic local solar plans. The 2011 edition contains the most recent lessons and successes from the 25 Solar America Cities and other communities promoting solar energy. Because DOE recognizes that there is no one path to solar market development, this guide introduces a range of policy and program options that can help a community build a local solar infrastructure.

Alcohol and drug policy model for the Canadian upstream petroleum industry

Energy Technology Data Exchange (ETDEWEB)

NONE

2007-09-15

This alcohol and drug policy model was developed to help employers manage and reduce the risks associated with drug and alcohol use in the workplace. The policy model outlined guidelines for establishing and implementing drug and alcohol policies, and discussed treatment programs and opportunities for re-employment. The model was developed by Enform, the upstream petroleum industry's safety and training arm, who used a previous guide developed by the Construction Owner's Association of Alberta (COAA) as a model. Enform's model provided a summary of key accountabilities across all levels of industry as well as the accepted minimum criteria for developing alcohol and drug policies. The model included guidelines and recommendations for employees, supervisors, and owners, employers, and contractors. The responsibilities of associations, organizations, and private companies were also outlined. An overview of recommended implementation plans was provided, as well as details of alcohol and drug use education programs and workplace rules. A supervisor's guide to implementation provided outlines of the causes of drug use among employees. tabs.

Guide of the bio-climatic architecture; Guide de l'architecture bioclimatique

Energy Technology Data Exchange (ETDEWEB)

Liebard, A [Observateur des Energies Renouvelables 75 - Paris (France); Herde, A de [Universite Catholique de Louvain (UCL), Louvain-la-Neuve (Belgium)

2004-07-01

This guide is the part six of a fundamental course on the bio-climatic architecture. This part is devoted to the urban development and the sustainable development in Europe. The context and the definitions of a sustainable town are proposed in the first part. The second part deals with the today tools, as the environmental policies, the urban development and economy, the HQE (high environmental quality) approach and the renewable energies use in urban areas. The third part proposes some applications of a sustainable urbanization, a climatic town planing and the energy conservation. (A.L.B.)

Policy Analysis, International Relations, and European Governance

DEFF Research Database (Denmark)

Jensen, Mads Christian Dagnis; Tatham, Michaël

2017-01-01

The article highlights the rationale of the special issue in terms of its objectives and guiding principles. It maps different evolutions and challenges within three analytical streams (1) regarding the field of policy analysis, (2) concerning the interaction between domestic and international...... affairs, and (3) with regards to the transformation of European Union governance in troubled times. These three research avenues highlight how not only European governance itself has evolved in a changing world, but also how the analysis of interests, institutions, and policy-making has morphed...

Consumer support for environmental policies. An application to purchases of green cars

Energy Technology Data Exchange (ETDEWEB)

Coad, Alex; Woersdorfer, Julia Sophie [Max Planck Institute of Economics, Evolutionary Economics Group, Kahlaische Strasse 10, 07745 Jena (Germany); De Haan, Peter [ETH Zurich, Institute for Environmental Decisions, CHN J73.2, Universitaetstr. 22, 8092 Zurich (Switzerland)

2009-05-15

This paper focuses on how consumer motivation can be tapped in order to encourage the adoption of cleaner technologies. Consumers are heterogeneous - they may be guided by intrinsic motivation or extrinsic motivation. While information provision policies (such as the energy label for cars) may be effective in encouraging certain consumers to adopt green cars, financial incentive schemes (such as subsidies or fines) may be more persuasive for extrinsically-motivated consumers. We develop a dynamic theory of adoption of environmental innovations, in which information-provision policies are followed by financial incentives (first 'carrot', then 'stick' incentives). Analysis of a survey dataset of Swiss households observes considerable heterogeneity in terms of support of information-provision or financial incentive policies, in line with our conjectures. Our results will be of particular interest to policymakers interested in guiding consumers towards cleaner technologies. (author)

Pumping system of 30,000 l/sec for CIME cyclotron

International Nuclear Information System (INIS)

Horbowa, A.; Buhler, S.; Blache, Ph.; Chevrollier, R.; Grolet, D.; Pilot, A.; Szott, Ph.; Languiller, J.; Gallardo, Ph.

1999-01-01

The cyclotron CIME (SPIRAL facilities) has to accelerate radioactive ions produced from primary heavy beams delivered by GANIL. To avoid beam losses by charge exchange on the residual gas, the ultimate pressure in the cyclotron is expected to be better than 5.10 -8 mbar. In order to reach such a low pressure, a system of 30.000 l/sec twin cryo-panels has been designed for being installed inside the cyclotron. Each cryo-panel will be individually cooled by a separate set of two cryo-generators. From cryo-generators to cryo-panels, the cooling power is transferred through heat-pipes over several meters. The complete system designed and constructed in the IPN and GANIL laboratories, is presently under testing at the GANIL location. (authors)

Single-mode 850-nm vertical-cavity surface-emitting lasers with Zn-diffusion and oxide-relief apertures for > 50 Gbit/sec OOK and 4-PAM transmission

Science.gov (United States)

Shi, Jin-Wei; Wei, Chia-Chien; Chen, Jyehong; Ledentsov, N. N.; Yang, Ying-Jay

2017-02-01

Vertical-cavity surface-emitting lasers (VCSELs) has become the most important light source in the booming market of short-reach (targeted at 56 Gbit/sec data rate per channel (CEI-56G) with the total data rate up to 400 Gbit/sec. However, the serious modal dispersion of multi-mode fiber (MMF), limited speed of VCSEL, and its high resistance (> 150 Ω) seriously limits the >50 Gbit/sec linking distance (50 Gbit/sec transmission due to that it can save one-half of the required bandwidth. Nevertheless, a 4.7 dB optical power penalty and the linearity of transmitter would become issues in the 4-PAM linking performance. Besides, in the modern OI system, the optics transreceiver module must be packaged as close as possible with the integrated circuits (ICs). The heat generated from ICs will become an issue in speed of VSCEL. Here, we review our recent work about 850 nm VCSEL, which has unique Zn-diffusion/oxide-relief apertures and special p- doping active layer with strong wavelength detuning to further enhance its modulation speed and high-temperature (85°C) performances. Single-mode (SM) devices with high-speed ( 26 GHz), reasonable resistance ( 70 Ω) and moderate output power ( 1.5 mW) can be achieved. Error-free 54 Gbit/sec OOK transmission through 1km MMF has been realized by using such SM device with signal processing techniques. Besides, the volterra nonlinear equalizer has been applied in our 4-PAM 64 Gbit/sec transmission through 2-km OM4 MMF, which significantly enhance the linearity of device and outperforms fed forward equalization (FFE) technique. Record high bit-rate distance product of 128.km is confirmed for optical-interconnect applications.

Policy for Research and Innovation in Latin America

Science.gov (United States)

Aguirre-Bastos, Carlos

2010-02-01

Latin America (LAC) is renewing efforts to build-up research and innovation (R&I) capacities, guided by policies that consider the need to transform the traditional science system into a more dynamic entity. Policies permitted the generation of new spaces to develop science, strengthen scientific communities, improve university-enterprise linkages, establish common agendas between public and private sectors, earmark special budgets, build new infrastructure, and improve the number and quality of scientific publications. In spite of much progress, LAC lags much behind developed countries, their universities rank lower than their international counterparts, the number of researchers is small and funding is below an appropriate threshold. Some countries have innovated in few economic sectors, while others remain technologically underdeveloped and much of the countries' innovative capacities remain untapped. It is believed that policies still have little influence on social and economic development and there exists dissatisfaction in the academic and entrepreneurial sectors with their quality and relevance or with the political will of governments to execute them. On the other hand, in the past decades, the complexity of innovation systems has increased considerably, and has yet to be taken fully into account in LAC policy definitions. The situation calls for decision makers to shape new framework conditions for R&I in a way that both processes co-evolve and are stimulated and guided on solutions to the major problems of society. Considering the main features of complex systems, self- organization, emergence and non-linearity, R&I policy measures need to be seen as interventions in such a system, as the use of traditional leverage effects used in the past for policy decisions are more and more obsolete. Policies must now use ``weak coordination mechanisms,'' foresight, mission statements, and visions. It is obvious that due to nonlinearities in the system, adaptive

Policy packages to achieve demand reduction

International Nuclear Information System (INIS)

Boardman, Brenda

2005-01-01

In many sectors and many countries, energy demand is still increasing, despite decades of policies to reduce demand. Controlling climate change is becoming more urgent, so there is a need to devise policies that will, virtually, guarantee demand reduction. This has to come from policy, at least in the UK, as the conditions do not exist, yet, when the consumers will 'pull' the market for energy efficiency or the manufacturers will use technological development to 'push' it. That virtuous circle has to be created by a mixture of consumer education and restrictions on manufacturers (for instance, permission to manufacture). The wider policy options include higher prices for energy and stronger product policies. An assessment of the effectiveness of different policy packages indicates some guiding principles, for instance that improved product policy must precede higher prices, otherwise consumers are unable to react effectively to price rises. The evidence will be assessed about the ways in which national and EU policies can either reinforce, duplicate or undermine each other. Another area of examination will be timescales: what is the time lag between the implementation of a policy (whether prices or product based) and the level of maximum reductions. In addition, the emphasis given to factors such as equity, raising investment funds and speed of delivery also influence policy design and the extent to which absolute carbon reductions can be expected

Aggregation factor analysis for protein formulation by a systematic approach using FTIR, SEC and design of experiments techniques.

Science.gov (United States)

Feng, Yan Wen; Ooishi, Ayako; Honda, Shinya

2012-01-05

A simple systematic approach using Fourier transform infrared (FTIR) spectroscopy, size exclusion chromatography (SEC) and design of experiments (DOE) techniques was applied to the analysis of aggregation factors for protein formulations in stress and accelerated testings. FTIR and SEC were used to evaluate protein conformational and storage stabilities, respectively. DOE was used to determine the suitable formulation and to analyze both the main effect of single factors and the interaction effect of combined factors on aggregation. Our results indicated that (i) analysis at a low protein concentration is not always applicable to high concentration formulations; (ii) an investigation of interaction effects of combined factors as well as main effects of single factors is effective for improving conformational stability of proteins; (iii) with the exception of pH, the results of stress testing with regard to aggregation factors would be available for suitable formulation instead of performing time-consuming accelerated testing; (iv) a suitable pH condition should not be determined in stress testing but in accelerated testing, because of inconsistent effects of pH on conformational and storage stabilities. In summary, we propose a three-step strategy, using FTIR, SEC and DOE techniques, to effectively analyze the aggregation factors and perform a rapid screening for suitable conditions of protein formulation. Copyright © 2011 Elsevier B.V. All rights reserved.

Econometric Methods for Causal Evaluation of Education Policies and Practices: A Non-Technical Guide

Science.gov (United States)

Schlotter, Martin; Schwerdt, Guido; Woessmann, Ludger

2011-01-01

Education policy-makers and practitioners want to know which policies and practices can best achieve their goals. But research that can inform evidence-based policy often requires complex methods to distinguish causation from accidental association. Avoiding econometric jargon and technical detail, this paper explains the main idea and intuition…

An index guiding temporal planting policies for wind erosion reduction

NARCIS (Netherlands)

Zhao, C.X.; Zheng, D.W.; Stigter, C.J.; He, W.Q.; Tuo, D.B.; Zhao, P.

2006-01-01

Vegetation cover has spatial as well as temporal characteristics, but the latter are often neglected. Temporal cover characteristics were explored to recommend planting policies for returning arable land into land better protected from serious wind erosion during late autumn, winter, and

Cloning, expression, purification, crystallization and initial crystallographic analysis of the preprotein translocation ATPase SecA from Thermus thermophilus

International Nuclear Information System (INIS)

Vassylyeva, Marina N.; Mori, Hiroyuki; Tsukazaki, Tomoya; Yokoyama, Shigeyuki; Tahirov, Tahir H.; Ito, Koreaki; Vassylyev, Dmitry G.

2006-01-01

The SecA ATPase from T. thermophilus was cloned, expressed, purified and crystallized. Complete diffraction data sets were collected for two crystal forms at 2.8 and 3.5 Å resolution, respectively. Determination of the structure is now in progress. The Thermus thermophilus gene encoding the preprotein translocation ATPase SecA was cloned and expressed and the purified protein was crystallized by the hanging-drop vapour-diffusion technique in two different space groups P3 1(2) 21 (a = b = 168.6, c = 149.8 Å) and P6 1(5) 22 (a = b = 130.9, c = 564.6 Å). The crystals, improved by macroseeding, diffracted to beyond 2.8 and 3.5 Å resolution for the trigonal and hexagonal crystal forms, respectively. Structure determination using the multiple isomorphous replacement method is in progress

Good Practice Guide Waste Minimization/Pollution Prevention

Energy Technology Data Exchange (ETDEWEB)

J Dorsey

1999-10-14

This Good Practice Guide provides tools, information, and examples for promoting the implementation of pollution prevention during the design phases of U.S. Department of Energy (DOE) projects. It is one of several Guides for implementing DOE Order 430.1, Life-cycle Asset Management. DOE Order 430.1 provides requirements for DOE, in partnership with its contractors, to plan, acquire, operate, maintain, and dispose of physical assets. The goals of designing for pollution prevention are to minimize raw material consumption, energy consumption, waste generation, health and safety impacts, and ecological degradation over the entire life of the facility (EPA 1993a). Users of this Guide will learn to translate national policy and regulatory requirements for pollution prevention into action at the project level. The Guide was written to be applicable to all DOE projects, regardless of project size or design phase. Users are expected to interpret the Guide for their individual project's circumstances, applying a graded approach so that the effort is consistent with the anticipated waste generation and resource consumption of the physical asset. This Guide employs a combination of pollution prevention opportunity assessment (PPOA) methods and design for environment (DfE) philosophies. The PPOA process was primarily developed for existing products, processes, and facilities. The PPOA process has been modified in this Guide to address the circumstances of the DOE design process as delineated in DOE Order 430.1 and its associated Good Practice Guides. This modified form of the PPOA is termed the Pollution Prevention Design Assessment (P2DA). Information on current nationwide methods and successes in designing for the environment also have been reviewed and are integrated into this guidance.

Contemporary intellectual property law and policy

CERN Document Server

MacQueen, Hector; Laurie, Graeme; Brown, Abbe

2011-01-01

Contemporary Intellectual Property: Law and Policy offers a unique perspective on intellectual property law, unrivalled amongst IP textbooks available today. Beyond providing an up-to-date account of intellectual property law, the text examines the complex policies that inform and guide modern IP law at the domestic (including Scottish), European and international levels, giving the reader a true insight into the discipline and the shape of things to come. The focus is on contemporary challenges to intellectual property law and policy and the reader is encouraged to engage critically both with the text and the subject matter. Carefully developed to ensure that the complexities of the subject are addressed in a clear and approachable manner, the extensive use of practical examples, exercises and visual aids throughout the text enliven the subject and stimulate the reader.

Contemporary intellectual property law and policy

CERN Document Server

Waelde, Charlotte; Kheria, Smita; Cornwell, Jane

2016-01-01

Contemporary Intellectual Property: Law and Policy offers a unique perspective on intellectual property law. It goes beyond an up-to-date account of the law and examines the complex policies that inform and guide modern intellectual property law at the domestic (including Scottish), European and international levels, giving the reader a true insight into the discipline and the shape of things to come. The focus is on contemporary challenges to intellectual property law and policy and the reader is encouraged to engage critically both with the text and the subject matter. Carefully developed to ensure that the complexities of the subject are addressed in a clear and approachable manner, the extensive use of practical examples, exercises and visual aids throughout the text enliven the subject and stimulate the reader.

Guide of the bio-climatic architecture; Guide de l'architecture bioclimatique

Energy Technology Data Exchange (ETDEWEB)

Liebard, A. [Observateur des Energies Renouvelables 75 - Paris (France); Herde, A. de [Universite Catholique de Louvain (UCL), Louvain-la-Neuve (Belgium)

2004-07-01

This guide is the part six of a fundamental course on the bio-climatic architecture. This part is devoted to the urban development and the sustainable development in Europe. The context and the definitions of a sustainable town are proposed in the first part. The second part deals with the today tools, as the environmental policies, the urban development and economy, the HQE (high environmental quality) approach and the renewable energies use in urban areas. The third part proposes some applications of a sustainable urbanization, a climatic town planing and the energy conservation. (A.L.B.)

Wastes in Aquitaine. A regional guide; Les dechets en Aquitaine. Guide regional

Energy Technology Data Exchange (ETDEWEB)

NONE

1995-04-01

In the framework of French environmental policy and municipal and industrial waste disposal programs, a guide is presented for the Aquitaine region, which gives a comprehensive information on waste disposal effects and waste processing. Waste types and associated regulations are presented, with emphasis on volumes and data for Aquitaine region, followed by information on the various environmental labels and waste collection procedures, processing and ultimate disposal systems, financial incentives and taxes, waste exchange systems... The various types of municipal, industrial, agricultural and food industry wastes are reviewed with information on their characteristics, volumes, legislation, collection, processing and upgrading, and disposal

Policies and Strategies for the Decommissioning of Nuclear and Radiological Facilities

International Nuclear Information System (INIS)

2011-01-01

This publication presents the main elements of policies and strategies for decommissioning activities of nuclear and radiological facilities. It is intended to help in facilitating proper and systematic planning, and safe, timely and cost effective implementation of all decommissioning activities. The policy establishes the principles for decommissioning and the strategy contains the approaches for the implementation of the policy. The publication will be a useful guide for strategic planners, waste managers, operators of facilities under decommissioning, regulators and other stakeholders.

Making the Most of Opportunities to Learn What Works: A School District's Guide. REL 2014-048

Science.gov (United States)

Akers, Lauren; Resch, Alexandra; Berk, Jillian

2014-01-01

This guide for district and school leaders shows how to recognize opportunities to embed randomized controlled trials (RCTs) into planned policies or programs. Opportunistic RCTs can generate strong evidence for informing education decisions--with minimal added cost and disruption. The guide also outlines the key steps to conduct RCTs and responds…

DOE program guide for universities and other research groups. Part I. DOE Research and Development Programs; Part II. DOE Procurement and Assistance Policies/Procedures

Energy Technology Data Exchange (ETDEWEB)

1980-03-01

This guide addresses the DOE responsibility for fostering advanced research and development of all energy resources, both current and potential. It is intended to provide, in a single publication, all the fundamental information needed by an institution to develop a potential working relationship with DOE. Part I describes DOE research and development programs and facilities, and identifies areas of additional research needs and potential areas for new research opportunities. It also summarizes budget data and identifies the DOE program information contacts for each program. Part II provides researchers and research administrators with an introduction to the DOE administrative policies and procedures for submission and evaluation of proposals and the administration of resulting grants, cooperative agreements, and research contracts. (RWR)

Environmental Policy and Technological Change

International Nuclear Information System (INIS)

Jaffe, Adam B.; Newell, Richard G.; Stavins, Robert N.

2002-01-01

The relationship between technological change and environmental policy has received increasing attention from scholars and policy makers alike over the past ten years. This is partly because the environmental impacts of social activity are significantly affected by technological change, and partly because environmental policy interventions themselves create new constraints and incentives that affect the process of technological developments. Our central purpose in this article is to provide environmental economists with a useful guide to research on technological change and the analytical tools that can be used to explore further the interaction between technology and the environment. In Part 1 of the article, we provide an overview of analytical frameworks for investigating the economics of technological change, highlighting key issues for the researcher. In Part 2, we turn our attention to theoretical analysis of the effects of environmental policy on technological change, and in Part 3, we focus on issues related to the empirical analysis of technology innovation and diffusion. Finally, we conclude in Part 4 with some additional suggestions for research

New Guiding Principles in Educational Policy: The Case of Germany.

Science.gov (United States)

Weiss, Manfred

1993-01-01

Whereas the shift toward pluralism, choice, deregulation, and parent empowerment reflects the market ideology's advance into education in other industrialized countries, the force driving the German movement is loss of political legitimization and the conflict-ridden state of educational policy. Past strategies for securing legitimization…

Generations in organizations. Ageing workforce and personnel policy as context for intergenerational conflict in local government

OpenAIRE

Platteau, Eva

2013-01-01

The topic of the dissertation is the collaboration between generations in the workplace. In the first chapter, this topic is situated in the context of the ‘ageing problem’. The question that is addressed is why the collaboration between generations has become a point of attention for the personnel policy, and more specifically for ‘age management’ that is targeted at keeping workers to ‘work longer’. Also, the context of the research, namely Flemish Local Government, is discussed. In the sec...

The industrial policy experience of the electronics industry in Malaysia

OpenAIRE

Rasiah, Rajah

2015-01-01

Despite the use of industrial policies to stimulate economic growth by several successful developers, latecomers have faced mixed experiences. Hence, this paper analyses the industrial policy experience of the electronics industry in Malaysia. A blend of institutions have guided technological upgrading in the industry, especially in the state of Penang. Smooth co-ordination between the state government, multinational corporations, national firms, and the federal government helped stimulate te...

Evolving institutional and policy frameworks to support adaptation strategies

Science.gov (United States)

Dave Cleaves

2014-01-01

Given the consequences and opportunities of the Anthropocene, what is our underlying theory or vision of successful adaptation? This essay discusses the building blocks of this theory, and how will we translate this theory into guiding principles for management and policy.

Phytoplasma phylogenetics based on analysis of secA and 23S rRNA gene sequences for improved resolution of candidate species of 'Candidatus Phytoplasma'.

Science.gov (United States)

Hodgetts, Jennifer; Boonham, Neil; Mumford, Rick; Harrison, Nigel; Dickinson, Matthew

2008-08-01

Phytoplasma phylogenetics has focused primarily on sequences of the non-coding 16S rRNA gene and the 16S-23S rRNA intergenic spacer region (16-23S ISR), and primers that enable amplification of these regions from all phytoplasmas by PCR are well established. In this study, primers based on the secA gene have been developed into a semi-nested PCR assay that results in a sequence of the expected size (about 480 bp) from all 34 phytoplasmas examined, including strains representative of 12 16Sr groups. Phylogenetic analysis of secA gene sequences showed similar clustering of phytoplasmas when compared with clusters resolved by similar sequence analyses of a 16-23S ISR-23S rRNA gene contig or of the 16S rRNA gene alone. The main differences between trees were in the branch lengths, which were elongated in the 16-23S ISR-23S rRNA gene tree when compared with the 16S rRNA gene tree and elongated still further in the secA gene tree, despite this being a shorter sequence. The improved resolution in the secA gene-derived phylogenetic tree resulted in the 16SrII group splitting into two distinct clusters, while phytoplasmas associated with coconut lethal yellowing-type diseases split into three distinct groups, thereby supporting past proposals that they represent different candidate species within 'Candidatus Phytoplasma'. The ability to differentiate 16Sr groups and subgroups by virtual RFLP analysis of secA gene sequences suggests that this gene may provide an informative alternative molecular marker for pathogen identification and diagnosis of phytoplasma diseases.

Policies on pets for healthy cities: a conceptual framework

OpenAIRE

Rock, Melanie J.; Adams, Cindy L.; Degeling, Chris; Massolo, Alessandro; McCormack, Gavin R.

2014-01-01

Drawing on the One Health concept, and integrating a dual focus on public policy and practices of caring from the Ottawa Charter for Health Promotion, we outline a conceptual framework to help guide the development and assessment of local governments' policies on pets. This framework emphasizes well-being in human populations, while recognizing that these outcomes relate to the well-being of non-human animals. Five intersecting spheres of activity, each associated with local governments' juri...

Anticipating and addressing the unintended consequences of health IT and policy: a report from the AMIA 2009 Health Policy Meeting.

Science.gov (United States)

Bloomrosen, Meryl; Starren, Justin; Lorenzi, Nancy M; Ash, Joan S; Patel, Vimla L; Shortliffe, Edward H

2011-01-01

Federal legislation (Health Information Technology for Economic and Clinical Health (HITECH) Act) has provided funds to support an unprecedented increase in health information technology (HIT) adoption for healthcare provider organizations and professionals throughout the U.S. While recognizing the promise that widespread HIT adoption and meaningful use can bring to efforts to improve the quality, safety, and efficiency of healthcare, the American Medical Informatics Association devoted its 2009 Annual Health Policy Meeting to consideration of unanticipated consequences that could result with the increased implementation of HIT. Conference participants focused on possible unintended and unanticipated, as well as undesirable, consequences of HIT implementation. They employed an input-output model to guide discussion on occurrence of these consequences in four domains: technical, human/cognitive, organizational, and fiscal/policy and regulation. The authors outline the conference's recommendations: (1) an enhanced research agenda to guide study into the causes, manifestations, and mitigation of unintended consequences resulting from HIT implementations; (2) creation of a framework to promote sharing of HIT implementation experiences and the development of best practices that minimize unintended consequences; and (3) recognition of the key role of the Federal Government in providing leadership and oversight in analyzing the effects of HIT-related implementations and policies.

A Policy Strategy for Carbon Capture and Storage

Energy Technology Data Exchange (ETDEWEB)

NONE

2012-09-05

Successful deployment of carbon capture and storage (CCS) is critically dependent on comprehensive policy support. While policy plays an important role in the deployment of many low-carbon technologies, it is especially crucial for CCS. This is because, in contrast to renewable energy or applications of energy efficiency, CCS generates no revenue, nor other market benefits, so long as there is no price on CO2 emissions. It is both costly to install and, once in place, has increased operating costs. Effective, well-designed policy support is essential in overcoming these barriers and the subsequent deployment of CCS technology. This guide for policy makers aims to assist those involved in designing national and international policies around CCS. It covers development of CCS from its early stages through to wide-scale deployment of the technology. The focus is both on incentives for conventional fossil-fuel CCS and for bioenergy with CCS (BECCS).

Advancing team-based primary health care: a comparative analysis of policies in western Canada.

Science.gov (United States)

Suter, Esther; Mallinson, Sara; Misfeldt, Renee; Boakye, Omenaa; Nasmith, Louise; Wong, Sabrina T

2017-07-17

We analyzed and compared primary health care (PHC) policies in British Columbia, Alberta and Saskatchewan to understand how they inform the design and implementation of team-based primary health care service delivery. The goal was to develop policy imperatives that can advance team-based PHC in Canada. We conducted comparative case studies (n = 3). The policy analysis included: Context review: We reviewed relevant information (2007 to 2014) from databases and websites. Policy review and comparative analysis: We compared and contrasted publically available PHC policies. Key informant interviews: Key informants (n = 30) validated narratives prepared from the comparative analysis by offering contextual information on potential policy imperatives. Advisory group and roundtable: An expert advisory group guided this work and a key stakeholder roundtable event guided prioritization of policy imperatives. The concept of team-based PHC varies widely across and within the three provinces. We noted policy gaps related to team configuration, leadership, scope of practice, role clarity and financing of team-based care; few policies speak explicitly to monitoring and evaluation of team-based PHC. We prioritized four policy imperatives: (1) alignment of goals and policies at different system levels; (2) investment of resources for system change; (3) compensation models for all members of the team; and (4) accountability through collaborative practice metrics. Policies supporting team-based PHC have been slow to emerge, lacking a systematic and coordinated approach. Greater alignment with specific consideration of financing, reimbursement, implementation mechanisms and performance monitoring could accelerate systemic transformation by removing some well-known barriers to team-based care.

Federal High Performance and Sustainable Buildings: Guiding Principles for the Laboratory Support Building (LSB)

Energy Technology Data Exchange (ETDEWEB)

Pope, Jason E.

2014-09-01

This report documents the federal Guiding Principles conformance effort for LSB at PNNL. The effort is part of continued progress toward a campus building inventory that is 100% compliant with the Guiding Principles. The report documentation provides a narrative of how the LSB complies with each of the Guiding Principles requirements. These narratives draw from the many sources that are explained in the text and rely on extensive data collection. The descriptions point to each of these sources, providing the reader with specific policies, procedures, and data points.

Exocyst SEC3 and Phosphoinositides Define Sites of Exocytosis in Pollen Tube Initiation and Growth

Czech Academy of Sciences Publication Activity Database

Bloch, D.; Pleskot, Roman; Pejchar, Přemysl; Potocký, Martin; Trpkošová, Pavlína; Cwiklik, Lukasz; Vukašinović, Nemanja; Sternberg, H.; Yalovsky, S.; Žárský, Viktor

2016-01-01

Roč. 172, č. 2 (2016), s. 980-1002 ISSN 0032-0889 R&D Projects: GA ČR GA13-19073S Institutional support: RVO:61389030 ; RVO:61388955 Keywords : polar cell-growth * arabidopsis-thaliana * plasma-membrane * vesicle trafficking * affects endocytosis * subunit sec3 * force-field * tip growth * complex * tobacco Subject RIV: EB - Genetics ; Molecular Biology; CF - Physical ; Theoretical Chemistry (UFCH-W) Impact factor: 6.456, year: 2016

The use of externality estimates in the calculation of adders by state PUC regulators

International Nuclear Information System (INIS)

Burtraw, D.; Palmer, K.; Krupnick, A.

1994-01-01

The primary focus of the U. S.-EC study is the development and illustration of methodologies for the estimation of marginal damages and associated externalities that result from the addition of electricity generating capacity in a specific reference environment. This paper describes how this information can be used to guide resource planning by electric utilities and State public utility commissions (PUCs). First, we discuss the 'second-best' policy environment in which PUCs must operate. We then discuss the use of 'adders' which are a policy tool that many PUCs are currently considering. Then, we introduce and estimate a formal model to calibrate these adders, based on estimates of externalities in order to promote economic efficiency in resource planning and investment decisions

The use of externality estimates in the calculation of adders by state PUC regulators

Energy Technology Data Exchange (ETDEWEB)

Burtraw, D; Palmer, K; Krupnick, A

1994-07-01

The primary focus of the U. S.-EC study is the development and illustration of methodologies for the estimation of marginal damages and associated externalities that result from the addition of electricity generating capacity in a specific reference environment. This paper describes how this information can be used to guide resource planning by electric utilities and State public utility commissions (PUCs). First, we discuss the 'second-best' policy environment in which PUCs must operate. We then discuss the use of 'adders' which are a policy tool that many PUCs are currently considering. Then, we introduce and estimate a formal model to calibrate these adders, based on estimates of externalities in order to promote economic efficiency in resource planning and investment decisions.

The Environmental Compliance Assessment Management Program (ECAMP) Air National Guard Supplement for The Environmental Assessment and Management (TEAM) Guide. Volume 2. (Revised)

National Research Council Canada - National Science Library

Krooks, David

1997-01-01

... (The Environmental Assessment and Management (TEAM) Guide), the ECAMP-ANG supplement was developed to examine Air Force Instructions, Air Force Manuals, and Air Force Policies in conjunction with the TEAM Guide...

FlySec: a risk-based airport security management system based on security as a service concept

Science.gov (United States)

Kyriazanos, Dimitris M.; Segou, Olga E.; Zalonis, Andreas; Thomopoulos, Stelios C. A.

2016-05-01

Complementing the ACI/IATA efforts, the FLYSEC European H2020 Research and Innovation project (http://www.fly-sec.eu/) aims to develop and demonstrate an innovative, integrated and end-to-end airport security process for passengers, enabling a guided and streamlined procedure from the landside to airside and into the boarding gates, and offering for an operationally validated innovative concept for end-to-end aviation security. FLYSEC ambition turns through a well-structured work plan into: (i) innovative processes facilitating risk-based screening; (ii) deployment and integration of new technologies and repurposing existing solutions towards a risk-based Security paradigm shift; (iii) improvement of passenger facilitation and customer service, bringing security as a real service in the airport of tomorrow;(iv) achievement of measurable throughput improvement and a whole new level of Quality of Service; and (v) validation of the results through advanced "in-vitro" simulation and "in-vivo" pilots. On the technical side, FLYSEC achieves its ambitious goals by integrating new technologies on video surveillance, intelligent remote image processing and biometrics combined with big data analysis, open-source intelligence and crowdsourcing. Repurposing existing technologies is also in the FLYSEC objectives, such as mobile application technologies for improved passenger experience and positive boarding applications (i.e. services to facilitate boarding and landside/airside way finding) as well as RFID for carry-on luggage tracking and quick unattended luggage handling. In this paper, the authors will describe the risk based airport security management system which powers FLYSEC intelligence and serves as the backend on top of which FLYSEC's front end technologies reside for security services management, behaviour and risk analysis.

Effects of Fiscal and Monetary Policy in the Great Recession

Directory of Open Access Journals (Sweden)

Gonzalo Caballero

2013-09-01

Full Text Available World economy is living a time of change, and the complexity of change has implied a new research agenda on the role of economic policy in society. The role, types and effects of economic policy have been major issues in economic science since its origins. Jean Tinbergen (1956 [1] established the basis for the traditional theory of economic policy in economics and he tried to show how economic knowledge could be organized to regulate and guide economic systems. Nevertheless, this traditional approach has been improved through several contributions, for example when Eggertsson (1997 [2] incorporated the existence of incomplete knowledge, endogenous politics and institutional change in the theory of economic policy.

Development of an omnibus policy for tobacco control in the Philippine department of health

Directory of Open Access Journals (Sweden)

Lee Edson Yarcia

2018-03-01

Tobacco control regime complexes and regulatory gaps result from the difficulty of determining issuance provisions that have been impliedly repealed. The analytical tool developed threshed out repealed provisions, which would allow actors and stakeholders to fulfil individual mandates. Both Omnibus Policy on Tobacco Control and 2017-2030 Policy Development Plan on Tobacco Control would guide the DOH in formulating policies that strengthen the Philippines´ compliance with the FCTC.

Transfer of technology to developing countries: unilateral and multilateral policy options

International Nuclear Information System (INIS)

Hockman, B.M.; Maskus, K.E.; Saggi, K.

2005-01-01

This paper analyzes national and international policy options to encourage the international transfer of technology, distinguishing between four major channels of such transfer: trade in products, trade in knowledge and technology, foreign direct investment, and intranational and international movement of people. A typology of countries and appropriate policy rules of thumb are developed as a guide to both national policymakers and multilateral rule making in the WTO. We argue that the optimal policy mix varies across countries and that there is a need for differentiation in the design and application of rules in trade agreements as well as for a more explicit focus on evaluation of the impacts of policies. (author)

Using tracking infrastructure to support public health programs, policies, and emergency response in New York City.

Science.gov (United States)

Jeffery, Nancy Loder; McKelvey, Wendy; Matte, Thomas

2015-01-01

To describe how the New York City (NYC) Tracking Program has used nationally mandated Secure Portal infrastructure and staff analytical expertise to support programs and inform policy. The NYC Health Department assesses, investigates, and acts on a wide range of environmental concerns to protect the health of New Yorkers. Specific examples of highly effective policies or initiatives that relied on the NYC Tracking Program are described, including restaurant sanitary grade posting, rat indexing, converting boilers to cleaner-burning fuels, reducing exposure to mercury from fish and contaminated products, and responding to Superstorm Sandy. The NYC Tracking Program supports the Health Department in using inspectional, administrative, and health data to guide operations. Tracking has also allowed internal and external partners to use these data to guide policy development.

Real Costs of Transportation and Influence of Pricing Policies

OpenAIRE

Small, Kenneth A.

1993-01-01

Sustainability of transportation depends on both behavior and technology. Behavior determines how much of various activities are undertaken; technology determines whether they are harmful to the environment. Policies can influence both: they provide behavior incentives, and they affect technological choices and guide technological change.

Impact of entrepreneurship policies on opportunity to startup

Directory of Open Access Journals (Sweden)

Ali Davari

2017-09-01

Full Text Available During the previous decades, policy makers have formulated policies for developing entrepreneurship in different countries in order to decrease unemployment and poverty toward sustainable development. Some of these policies include encouraging people to be an entrepreneur, opportunity creation, educating new skills to entrepreneurs and so on. In recent years an appropriate context has been formed for entrepreneurship development in Iran and some programs have been executed. Therefore, formulating appropriate frameworks to guide Iranian government in this way is a necessity. This paper evaluates the impact of entrepreneurship policies on opportunity to startup in Iran. The results of path analysis indicate that supportive financial and non-financial actions influence positively on opportunity to startup. In addition, education and culture also influence positively on opportunity to startup. Finally, legislation also positively influences on opportunity to startup.

Energy sector methane recovery and use: the importance of policy

Energy Technology Data Exchange (ETDEWEB)

Tom Kerr; Michelle Hershman

2009-08-15

To raise awareness about appropriate policy options to advance methane recovery and use in the energy sector, the IEA has conducted a series of analyses and studies over the past few years. This report continues IEA efforts by providing policy makers with examples and best practices in methane mitigation policy design and implementation. This report offers an overview of four types of methane mitigation projects that have the strongest links to the energy sector: oil and gas methane recovery and reduction of leaks and losses; coal mine methane; landfill methane; and manure methane recovery and use. It identifies successful policies that have been used to advance these important projects. This information is intended to guide policy makers as they search for low-cost, near-term solutions to climate change. 38 refs., 10 figs., 1 app.

Teaching Guide on International Terrorism: Definitions, Causes, and Responses.

Science.gov (United States)

United States Inst. of Peace, Washington, DC.

Dealing with terrorism has become the centerpiece of United States foreign policy today. Yet terrorism--its definition, causes, and methods of dealing with it--has rarely been dealt with in high school courses. The United States Institute of Peace has developed this 3-lesson plan (for 45-minute class periods) teaching guide, aimed at grades 11 and…

Good Practice Guide Waste Minimization/Pollution Prevention; TOPICAL

International Nuclear Information System (INIS)

J Dorsey

1999-01-01

This Good Practice Guide provides tools, information, and examples for promoting the implementation of pollution prevention during the design phases of U.S. Department of Energy (DOE) projects. It is one of several Guides for implementing DOE Order 430.1, Life-cycle Asset Management. DOE Order 430.1 provides requirements for DOE, in partnership with its contractors, to plan, acquire, operate, maintain, and dispose of physical assets. The goals of designing for pollution prevention are to minimize raw material consumption, energy consumption, waste generation, health and safety impacts, and ecological degradation over the entire life of the facility (EPA 1993a). Users of this Guide will learn to translate national policy and regulatory requirements for pollution prevention into action at the project level. The Guide was written to be applicable to all DOE projects, regardless of project size or design phase. Users are expected to interpret the Guide for their individual project's circumstances, applying a graded approach so that the effort is consistent with the anticipated waste generation and resource consumption of the physical asset. This Guide employs a combination of pollution prevention opportunity assessment (PPOA) methods and design for environment (DfE) philosophies. The PPOA process was primarily developed for existing products, processes, and facilities. The PPOA process has been modified in this Guide to address the circumstances of the DOE design process as delineated in DOE Order 430.1 and its associated Good Practice Guides. This modified form of the PPOA is termed the Pollution Prevention Design Assessment (P2DA). Information on current nationwide methods and successes in designing for the environment also have been reviewed and are integrated into this guidance

BECOMING A TOUR GUIDE: ANALYZING THE MOTIVATIONS

Directory of Open Access Journals (Sweden)

Monika PRAKASH

2010-06-01

Full Text Available Guides play a vital role in this process bringing satisfaction to tourists visiting a country or region/state. The opportunity of direct interaction with the tourists makes them all the more responsible for projecting the correct image of the country/region, giving factually correct information about the destination, ensuring the safety and well being of the tourists as well as pleasing and satisfying the stay for them during their visits. Over last few years there has been a greater interest in tour guide profession especially in the northern region of India.The purpose of this study is to identify the motivations that led to choosing tour guiding as a profession and career. There appears to be a significant difference in such motivation in different regions of the country. A comparison in motivations in two regions (north vs. east was made. Based on primary data collection paper attempts to discuss what has motivated the youth to take up tour guiding profession- whether such motivation is positive of negative. In either case policy makers may decide what type of support programs need to be introduced by the state and other agencies like educational, rearing and counselling, financial support, social security, or any other type of interventions.

Employer's Guide: A Time for Action on Sexual Harassment in the Workplace = Guide de L'Employeur: Les Enjeux du Harcelement Sexuel au Travail.

Science.gov (United States)

Ontario Women's Directorate, Toronto.

Harassment, like other forms of violence against women, is not a new problem. It is not a problem that will just go away, but it can be stopped. This guide is designed for use by organizations and employers to help them develop policies and implement programs in their workplace that address workplace sexual harassment. It focuses on Canadian…

Modelling climate change under no-policy and policy emissions pathways

International Nuclear Information System (INIS)

Wigley, T.M.L.

2003-01-01

Future emissions under the SRES scenarios are described as examples of no-climate-policy scenarios. The production of policy scenarios is guided by Article 2 of the UN Framework Convention on Climate Change, which requires stabilization of greenhouse-gas concentrations. It is suggested that the choice of stabilization targets should be governed by the need to avoid dangerous interference with the climate system, while the choice of the pathway towards a given target should be determined by some form of cost-benefit analysis. The WRE (Wigley, Richels and Edmonds) concentration profiles are given as examples of stabilization pathways, and an alternative 'overshoot' pathway is introduced. Probabilistic projections (as probability density functions - pdfs) for global-mean temperature under the SRES scenarios are given. The relative importance of different sources of uncertainty is determined by removing individual sources of uncertainty and examining the change in the output temperature pdf. Emissions and climate sensitivity uncertainties dominate, while carbon cycle, aerosol forcing and ocean mixing uncertainties are shown to be small. It is shown that large uncertainties remain even if the emissions are prescribed. Uncertainties in regional climate change are defined by comparing normalized changes (i.e., changes per 1C global-mean warming) across multiple models and using the inter-model standard deviation as an uncertainty metric. Global-mean temperature projections for the policy case are given using the WRE profiles. Different stabilization targets are considered, and the overshoot case for 550ppm stabilization is used to quantify the effects of pathway differences. It is shown that large emissions reductions (from the no-policy to the policy case) will lead to only relatively small reductions in warming over the next 100 years

Test-retest reliability of the 20-sec Wingate test to assess anaerobic power in children with cerebral palsy

NARCIS (Netherlands)

Dallmeijer, A.J.; Scholtes, V.A.B.; Brehm, M.A.; Becher, J.G.

2013-01-01

OBJECTIVE: The aim of this study was to determine the test-retest reliability of the 20-sec Wingate anaerobic test in children with cerebral palsy. DESIGN: Participants were 22 ambulant children with cerebral palsy, with Gross Motor Function Classification System levels I (limitations in advanced

Test-Retest Reliability of the 20-sec Wingate Test to Assess Anaerobic Power in Children with Cerebral Palsy

NARCIS (Netherlands)

Dallmeijer, Annet J.; Scholtes, Vanessa A. B.; Brehm, Merel-Anne; Becher, Jules G.

2013-01-01

Objective: The aim of this study was to determine the test-retest reliability of the 20-sec Wingate anaerobic test in children with cerebral palsy. Design: Participants were 22 ambulant children with cerebral palsy, with Gross Motor Function Classification System levels I (limitations in advanced

Aerobic Biodegradation of Oily Wastes: A Field Guide For Federal On-scene Coordinators

Science.gov (United States)

Intentionally limited in scope to best serve the requirements of the Region 6 Oil Program, this field guide consists of three parts complemented by appendices. Helps evaluate environment and consider factors, existing regulations/policies, operation issues

Integrated environmental policy: A review of economic analysis.

Science.gov (United States)

Wiesmeth, Hans; Häckl, Dennis

2017-04-01

Holistic environmental policies, which emerged from a mere combination of technical activities in waste management some 40 years ago, constitute the most advanced level of environmental policies. These approaches to environmental policy, among them the policies in integrated waste management, attempt to guide economic agents to an environment-friendly behaviour. Nevertheless, current holistic policies in waste management, including policies on one-way drinks containers and waste electrical and electronic equipment, and implementations of extended producer responsibility with further applications to waste electrical and electronic equipment, reveal more or less severe deficiencies - despite some positive examples. This article relates these policy failures, which are not necessarily the result of an insufficient compliance with the regulations, to missing constitutive elements of what is going to be called an 'integrated environmental policy'. This article therefore investigates - mostly from a practical point of view - constitutive elements, which are necessary for a holistic policy to serve as a well-functioning allocation mechanism. As these constitutive elements result from a careful 'integration' of the environmental commodities into the economic allocation problems, we refer to these policies as 'integrated environmental policies'. The article also discusses and illustrates the main steps of designing such a policy - for waste electrical and electronic equipment and a (possible) ban of Glyphosat in agriculture. As these policies are dependent on economic and political stability with environmental awareness sufficiently developed, the article addresses mostly waste management policies in highly industrialised countries.

Renewable Energy Policy Country Profiles. 2011 version

Energy Technology Data Exchange (ETDEWEB)

Teckenburg, E.; Rathmann, M.; Winkel, T. [ECOFYS, Utrecht (Netherlands); Ragwitz, M.; Steinhilber, S. [Fraunhofer Institute for Systems and Innovation Research ISI, Karlsruhe (Germany); Resch, G.; Panzer, C.; Busch, S. [Energy Economics Group EEG, Technical University Vienna, Vienna (Austria); Konstantinaviciute, I. [Lithuanian Energy Institute, Kaunas (Lithuania)

2011-08-15

The core objective of the project RE-Shaping is to assist Member State (MS) governments in preparing for the implementation of Directive 2009/28/EC and to guide a European policy for RES in the mid- to long term. The past and present success of policies for renewable energies will be evaluated and recommendations derived to improve future RES support schemes. The effectiveness and the efficiency of current and future RES support schemes is analysed with specific focus on a single European market for renewable electricity products. Current best practices are identified, and (future) costs of RES and the corresponding support necessary to initiate stable growth are assessed. Better integration of RES policies with climate and innovation policy as well as liberalised energy markets will be analysed and promoted. Options for flexibility between Member States will be analysed. The future deployment of RES in each MS will be calculated based on the Green-X model to assist MS in implementing national action plans and to support a long term vision of the European RES policy. The latter will be based on an in-depth analysis of the long term RES potentials and costs. The impact of policies on risks for RES financing will be analysed and improved policies and financing instruments will be proposed.

Inflation Targeting as the Monetary Policy Framework: Bangladesh Perspective

Directory of Open Access Journals (Sweden)

Mohammed SAIFUL ISLAM

2011-06-01

Full Text Available Inflation targeting strategy has become a widely accepted monetary policy framework in many countries all over the world. Our study finds that the central bank of Bangladesh is neither inflation targeting nor does follow any other rule-guided monetary policy, rather the policy is formulated with substantial discretion under the guidelines of donor agencies. This paper provides the evidence that monetary sector of Bangladesh economy has gained considerable degree of maturity and fulfils a number of prerequisites to adopt inflation targeting strategy. Using data over 1980-2010 we estimate an error correction model in order to examine if interest rate policy could fight the inflation. This is evident that deviation in inflation from target can be corrected via the changes in interest rate. Empirical findings jointly with few descriptive statistics provide strong evidence to recommend inflation targeting as the monetary policy strategy for Bangladesh.

Implementation lessons for school food policies and marketing restrictions in the Philippines: a qualitative policy analysis.

Science.gov (United States)

Reeve, Erica; Thow, Anne Marie; Bell, Colin; Engelhardt, Katrin; Gamolo-Naliponguit, Ella Cecilia; Go, John Juliard; Sacks, Gary

2018-01-23

The school environment can enhance children's skills, knowledge and behaviours in relation to healthy eating. However, in many countries, unhealthy foods are commonly available in schools, and children can be exposed to aggressive marketing by the food industry. Taking the perspective of policymakers, this study aimed to identify barriers and enablers to effective school food policy development and implementation in the Philippines. In May 2016, semi-structured interviews were conducted with 21 policymakers and stakeholders involved in school food policymaking and implementation in the Philippines. The Health Policy Analysis Triangle was used to identify interview questions and to guide the thematic analysis. These included the political and socio-environmental context, strengths and limitations of existing policy content, roles and behaviours of actors, implementation processes, policy outcomes, and opportunities to improve policy coherence. The Department of Education's policy 'Orders' represented a relatively strong policy framework for the education sector of the Philippines. However, a lack of human and financial resources for implementation, planning, and policy enforcement limited the impact of the policy on the healthiness of school food provision. Ambiguity in policy wording allowed a wide interpretation of the foods eligible to be provided in schools, and led to difficulties in effective monitoring and enforcement. Food companies used existing relationships with schools to promote their brands and compromise the establishment of a stronger food policy agenda. We found a motivated group of actors engaging in policy-oriented learning and advocating for a stronger policy alternative so as to improve the school food environment. The adoption of policy mechanisms being used to promote healthy dietary practices in the school setting will be strengthened by more robust implementation planning processes, and resources to support implementation and enforcement

[Participatory design guide for mental health promotion in prisons].

Science.gov (United States)

Bustamante Navarro, R; Paredes-Carbonell, J J; Aviñó Juan-Ulpiano, D; González Rubio, J; Pitarch Monzó, C; Martínez Martínez, L; Arroyo-Cobo, J M

2013-01-01

[corrected] The main aim was to describe the issues and the participatory process required to design a Guide to promotemental health in prison through group activities. We reviewed the bibliography, the mental health policies, the workshops about healthy mental habits, and a video about protection and risk factors. We identified the stakeholders and sought their points of view about the topics included in the Guide. We decided on the contents of the Guide and the incorporation of the health assets model and the perspectives provided by gender and cultural diversity. After the initial design of the modules and sessions, we started a pilot in the Prison of Valencia and the Prison of Zaragoza with women and men from different cultures, incorporating the suggested improvements, unifying contents and the discursive style. The guide is formed by: a preface, introduction, description, modules, sessions and evaluation. It has 6 modules and 19 sessions on: health and motivation; self-esteem; health and emotions; more assets to improve health: relax, positive thinking, keeping calm, communication and problem resolution; progress is possible: resiliency and starring in my own change. Each session consists of: activities (objectives, material, allocated time and development), theoretical material and tabbed sheets for activities. The guide is available in print and online versions. A guide has been elaborated with involved stakeholders and the opinion of the prison population.

Guide to ground water remediation at CERCLA response action and RCRA corrective action sites

International Nuclear Information System (INIS)

1995-10-01

This Guide contains the regulatory and policy requirements governing remediation of ground water contaminated with hazardous waste [including radioactive mixed waste (RMW)], hazardous substances, or pollutants/contaminants that present (or may present) an imminent and substantial danger. It was prepared by the Office of Environmental Policy and Assistance, RCRA/CERCLA Division (EH-413), to assist Environmental Program Managers (ERPMs) who often encounter contaminated ground water during the performance of either response actions under CERCLA or corrective actions under Subtitle C of RCRA. The Guide begins with coverage of the regulatory and technical issues that are encountered by ERPM's after a CERCLA Preliminary Assessment/Site Investigation (PA/SI) or the RCRA Facility Assessment (RFA) have been completed and releases into the environment have been confirmed. It is based on the assumption that ground water contamination is present at the site, operable unit, solid waste management unit, or facility. The Guide's scope concludes with completion of the final RAs/corrective measures and a determination by the appropriate regulatory agencies that no further response action is necessary

Electrofocusing the compost organic matter obtained by coupling SEC-PAGE.

Science.gov (United States)

Cavani, Luciano; Trubetskaya, Olga; Grigatti, Marco; Trubetskoj, Oleg; Ciavatta, Claudio

2008-07-01

Humic acids (HA)-like extracted from compost at the beginning (t(0)) and after 130 days of composting (t(130)) were fractionated by coupling size exclusion chromatography to polyacrylamide gel electrophoresis (SEC-PAGE). HA-like fractions with the same molecular size (MS) and electrophoretic mobility were pooled and further characterised by analytical polyacrylamide gel electrofocusing (EF) and compared with HA separated from a Typic Chernozem soil. During the composting process all fractions were subjected to quantitative and qualitative modifications: the high MS fraction was degraded, the mid MS fractions were qualitatively changed, the content of low MS fractions increased and changed qualitatively. The main changes in EF pattern of the non fractionated HA-like t(130) were associated to low MS fractions. Such data seem to be reliable for explanation what mechanisms and monitoring of the evolution of the compost organic matter for their agricultural uses.

From Hume's Law To Policy Analysis For Human Development - Sen after Dewey, Myrdal, Streeten, Stretton and Haq

NARCIS (Netherlands)

D.R. Gasper (Des)

2008-01-01

markdownabstractAbstract: Much of Amartya Sen’s work has been directly policy-related, but his methodology of policy analysis has not been explained in detail. Action-related social science involves value-imbued procedures that guide the numerous unavoidable choices. This theme was explored

MRI-guided vacuum-assisted breast biopsy: comparison with stereotactically guided and ultrasound-guided techniques

Energy Technology Data Exchange (ETDEWEB)

Imschweiler, Thomas; Freiwald, Bianka; Kubik-Huch, Rahel A. [Kantonspital Baden AG, Institute for Radiology, Baden (Switzerland); Haueisen, Harald [Kantonspital Aarau AG, Institute for Radiology, Aarau (Switzerland); Kampmann, Gert [Clinica Sant' Anna, Lugano, Sorengo (Switzerland); Rageth, Luzi [Adjumed Services AG, Zurich (Switzerland); Seifert, Burkhardt [Institute for Social and Preventive Medicine, University of Zurich, Division of Biostatistics, Zuerich (Switzerland); Rageth, Christoph [Breast Centre, Zurich (Switzerland)

2014-01-15

To analyse the development of MRI-guided vacuum-assisted biopsy (VAB) in Switzerland and to compare the procedure with stereotactically guided and ultrasound-guided VAB. We performed a retrospective analysis of VABs between 2009 and 2011. A total of 9,113 VABs were performed. Of these, 557 were MRI guided. MRI-guided VAB showed the highest growth rate (97 %) of all three procedures. The technical success rates for MRI-guided, stereotactically guided and ultrasound-guided VAB were 98.4 % (548/557), 99.1 % (5,904/5,960) and 99.6 % (2,585/2,596), respectively. There were no significant differences (P = 0.12) between the MRI-guided and the stereotactically guided procedures. The technical success rate for ultrasound-guided VAB was significantly higher than that for MRI-guided VAB (P < 0.001). There were no complications using MRI-guided VAB requiring open surgery. The malignancy diagnosis rate for MRI-guided VAB was similar to that for stereotactically guided VAB (P = 0.35). MRI-guided VAB is a safe and accurate procedure that provides insight into clinical breast findings. (orig.)

Tourism and spatial transformations; implications for policy and planning

NARCIS (Netherlands)

Ashworth, G.J.; Dietvorst, A.G.J.

1995-01-01

The transformation of space by tourism and recreation is examined and the implications for tourism policy and planning are drawn out. A general model of transformation as a guide to intervention is presented. The first part of the book focuses on the procedures and includes case-studies from the

Science Under Attack Public Policy, Science Education, and the Emperor's New Clothes

International Nuclear Information System (INIS)

Krauss, Lawrence

2005-01-01

The popular debate about the teaching of intelligent design in public schools is but one quandary for scientists and policy makers. Given recent developments which have worked to breed a general distrust of science, it is evident that researchers and politicians alike should be wary of using popular opinion as a guide for policy and pedagogy when it comes to science in public education. Dr. Krauss will qualify this complex issue and will address how educators, policy makers and scientists can work effectively to prevent public misconceptions of science.

Housing Welfare Policies in Scandinavia

DEFF Research Database (Denmark)

Jensen, Lotte

2013-01-01

It is commonplace to refer to the Nordic countries of Sweden, Norway, Denmark, Finland and Iceland as a distinctive and homogenous welfare regime. As far as social housing is concerned, however, the institutional heritage of the respective countries significantly frames the ways in which social...... housing is understood, regulated and subsidized, and, in turn, how housing regimes respond to the general challenges to the national welfare states. The paper presents a historical institutionalist approach to understanding the diversity of regime responses in the modern era characterized by increasing...... marketization, welfare criticism and internationalization. The aim is to provide outside readers a theoretically guided empirical insight into Scandinavian social housing policy. The paper first lines up the core of the inbuilt argument of historical institutionalism in housing policy. Secondly, it briefly...

Career cartography: a conceptualization of career development to advance health and policy.

Science.gov (United States)

Feetham, Suzanne; Doering, Jennifer J

2015-01-01

The purpose of this article is to propose a conceptualization of career development that emphasizes the interdependence between research, practice, and policy. Career cartography applies three decades of career development experience to lay out a systematic, comprehensive, and iterative approach for planning and communicating the outcomes of science at any career stage. To inform practice and policy, nurse researchers must be clear on the intended destination and trajectory of the science, and be skilled in communicating that science and vision to diverse stakeholders. Career cartography builds on the science of cartography, is developed within the context of public and health policy, and is composed of several components, including a destination statement, career mapping, a supportive career cartography team, and use of communication and dissemination strategies. The successful utilization of career cartography may accelerate advancement of individual careers, scientific impact, and the discipline as a whole by guiding nurse researchers to be deliberative in career planning and to communicate successfully the outcomes of research across a wide variety of stakeholders. Career cartography provides a framework for planning a nurse researcher's program of research and scholarship to advance science, policy, and health of the public. Career cartography guides nurse researchers to realize their full potential to advance the health of the public and inform public and health policy in academic and practice environments. © 2014 Sigma Theta Tau International.

Investigating Underlying Principles to Guide Health Impact Assessment

Directory of Open Access Journals (Sweden)

Ali Fakhri

2014-06-01

Full Text Available Background Many countries conduct Health Impact Assessment (HIA of their projects and policies to predict their positive and negative health impacts. In recent years many guides have been developed to inform HIA practice, largely reflecting local developments in HIA. These guides have often been designed for specific contexts and specific need, making the choice between guides difficult. The objective of the current study is to identify underlying principles in order to guide HIA practice in Iran. Methods This study was conducted in three stages: 1 Studies comparing HIA guidelines were reviewed to identify criteria used for comparison seeking emphasized principles. 2 The HIA characteristics extracted from published papers were categorized in order to determine the principles that could guide HIA practice. 3 Finally, these principles were agreed by experts using nominal group technique. Results The review of the studies comparing HIA guides demonstrated there are no clear comparison criteria for reviewing HIA guides and no study mentioned HIA principles. Investigating the HIA principles from peer-reviewed papers, we found 14 issues. These were, considering of general features in planning and conducting HIAs such as HIA stream, level, timing and type, considering of the wider socio-political and economic context, considering of economic, technical and legal aspects of HIA and capacities for HIA, rationality and comprehensiveness, using appropriate evidence, elaborating on HIA relation to other forms of Impact Assessment, considering of equity, and encouraging intersectoral and interdisciplinary cooperation, involvement of stakeholders and transparency as underlying principles to guide HIA practice. The results emphasize how critical these technical as well as tactical considerations are in the early scoping step of an HIA which plans the conduct of the HIA in reponse to local contextual issues. Conclusion Determining the principles of HIA from

Investigating underlying principles to guide health impact assessment.

Science.gov (United States)

Fakhri, Ali; Maleki, Mohammadreza; Gohari, Mahmoodreza; Harris, Patrick

2014-06-01

Many countries conduct Health Impact Assessment (HIA) of their projects and policies to predict their positive and negative health impacts. In recent years many guides have been developed to inform HIA practice, largely reflecting local developments in HIA. These guides have often been designed for specific contexts and specific need, making the choice between guides difficult. The objective of the current study is to identify underlying principles in order to guide HIA practice in Iran. This study was conducted in three stages: 1) Studies comparing HIA guidelines were reviewed to identify criteria used for comparison seeking emphasized principles. 2) The HIA characteristics extracted from published papers were categorized in order to determine the principles that could guide HIA practice. 3) Finally, these principles were agreed by experts using nominal group technique. The review of the studies comparing HIA guides demonstrated there are no clear comparison criteria for reviewing HIA guides and no study mentioned HIA principles. Investigating the HIA principles from peer-reviewed papers, we found 14 issues. These were, considering of general features in planning and conducting HIAs such as HIA stream, level, timing and type, considering of the wider socio-political and economic context, considering of economic, technical and legal aspects of HIA and capacities for HIA, rationality and comprehensiveness, using appropriate evidence, elaborating on HIA relation to other forms of Impact Assessment, considering of equity, and encouraging intersectoral and interdisciplinary cooperation, involvement of stakeholders and transparency as underlying principles to guide HIA practice. The results emphasize how critical these technical as well as tactical considerations are in the early scoping step of an HIA which plans the conduct of the HIA in reponse to local contextual issues. Determining the principles of HIA from peer-reviewed papers provides an opportunity for guiding

Information technology in developing countries: a study to guide policy formulation

NARCIS (Netherlands)

de Boer, S.J.; Walbeek, M.M.

1999-01-01

This article discusses the information gap between industrialised and developing countries. In view of this gap, the Dutch Ministry of Development Co-operation decided to finance research aimed at formulating policy recommendations on the removal of bottlenecks preventing or slowing down the growth

Can We Envision a Bettor's Guide to Climate Prediction Markets?

Science.gov (United States)

Trexler, M.

2017-12-01

It's one thing to set up a climate prediction market, it's another to find enough informed traders to make the market work. Climate bets could range widely, from purely scientific or atmospheric metrics, to bets that involve the interplay of science, policy, economic, and behavioral outcomes. For a topic as complex and politicized as climate change, a Bettor's Guide to Climate Predictions could substantially expand and diversify the pool of individuals trading in the market, increasing both its liquidity and decision-support value. The Climate Web is an on-line and publically accessible Beta version of such a Bettor's Guide, implementing the knowledge management adage: "if only we knew what we know." The Climate Web not only curates the key literature, news coverage, and websites relating to more than 100 climate topics, from extreme event exceedance curves to climate economics to climate risk scenarios, it extracts and links together thousands of ideas and graphics across all of those topics. The Climate Web integrates the many disciplinary silos that characterize today's often dysfunctional climate policy conversations, allowing rapid cross-silo exploration and understanding. As a Bettor's Guide it would allow prediction market traders to better research and understand their potential bets, and to quickly survey key thinking and uncertainties relating to those bets. The availability of such a Bettor's Guide to Climate Predictions should make traders willing to place more bets than they otherwise would, and should facilitate higher quality betting. The presentation will introduce the knowledge management dimensions and challenges of climate prediction markets, and introduce the Climate Web as one solution to those challenges.

Guide to the safety design examination about light water reactor facilities for power generation

International Nuclear Information System (INIS)

Anon.

1977-01-01

This guide was compiled to evaluate the validity of the design policy when the safety design is examined at the time of the application for approval of the installation of nuclear reactors. About 7 years has elapsed since the existing guide was established, and the more appropriate guide to evaluate the safety should be made on the basis of the knowledge and experience accumulated thereafter. The range of application of this guide is limited to the above described evaluation, and it is not intended as the general standard for the design of nuclear reactors. First, the definition of the words used in this guide is given. Then, the guide to the safety examination is described about the general matters of reactor facilities, nuclear reactors and the measuring and controlling system, reactor-stopping system, reactivity-controlling system and safety protection system, reactor-cooling system, reactor containment vessels, fuel handling and waste treatment system. Several matters which require attention in the application of this guide or the clarification of the significance and interpretation of the guide itself were found, therefore the explanation about them was added at the end of this guide. (Kako, I.)

Identifying Priorities for Aging Policies in Two Portuguese Communities.

Science.gov (United States)

Bárrios, Maria João; Fernandes, Ana Alexandre; Fonseca, António Manuel

2018-02-20

The aging population has an impact on health, social, and economic issues in regard to individuals, communities, and organizations. The challenge for local policies in response to aging is to create sufficient resources to meet the population's needs, wishes, and rights as people age. Active aging constitutes one of the guiding perspectives on policies. Taking into account the local governance perspective, the Model for Aging Local Policies Analysis (MALPA) was created in order to convert the active aging paradigm into a practical approach, as a technique to evaluate and analyze local aging policies. In this research, the MALPA instrument was applied in two Portuguese communities (Coruche and Oeiras). The objective was to identify the intervention priorities of aging policies in both communities, determining whether the instrument can facilitate the development of proposals for the improvement of local aging policies. It was possible to evaluate the communities and programs, identifying the least appropriate policy actions regarding the intervention priorities. The results allowed us to identify 10 priorities about collaborative governance, involvement of the elderly in the policy-making process, lifelong learning, economic hardship, policies for all ages, isolated vulnerable and fragile groups, intergenerational contacts, safety in all policies, labor opportunities, and conditions and transport network improvement.

Dress Codes Blues: An Exploration of Urban Students' Reactions to a Public High School Uniform Policy

Science.gov (United States)

DaCosta, Kneia

2006-01-01

This qualitative investigation explores the responses of 22 U.S. urban public high school students when confronted with their newly imposed school uniform policy. Specifically, the study assessed students' appraisals of the policy along with compliance and academic performance. Guided by ecological human development perspectives and grounded in…

Obstacles and Enablers on the Way towards Integrated Physical Activity Policies for Childhood Obesity Prevention: An Exploration of Local Policy Officials’ Views

Directory of Open Access Journals (Sweden)

Anna-Marie Hendriks

2016-01-01

Full Text Available Background. Limited physical activity (PA is a risk factor for childhood obesity. In Netherlands, as in many other countries worldwide, local policy officials bear responsibility for integrated PA policies, involving both health and nonhealth domains. In practice, its development seems hampered. We explore which obstacles local policy officials perceive in their effort. Methods. Fifteen semistructured interviews were held with policy officials from health and nonhealth policy domains, working at strategic, tactic, and operational level, in three relatively large municipalities. Questions focused on exploring perceived barriers for integrated PA policies. The interviews were deductively coded by applying the Behavior Change Ball framework. Findings. Childhood obesity prevention appeared on the governmental agenda and all officials understood the multicausal nature. However, operational officials had not yet developed a tradition to develop integrated PA policies due to insufficient boundary-spanning skills and structural and cultural differences between the domains. Tactical level officials did not sufficiently support intersectoral collaboration and strategic level officials mainly focused on public-private partnerships. Conclusion. Developing integrated PA policies is a bottom-up innovation process that needs to be supported by governmental leaders through better guiding organizational processes leading to such policies. Operational level officials can assist in this by making progress in intersectoral collaboration visible.

Windows Vista Administrator's Pocket Guide

CERN Document Server

Stanek, William R

2007-01-01

Portable and precise, this pocket-sized guide delivers immediate answers for the day-to-day administration of Windows Vista. Zero in on core support and maintenance tasks using quick-reference tables, instructions, and lists. You'll get the precise information you need to solve problems and get the job done-whether you're at your desk or in the field! Get fast facts to: Install and configure Windows Vista-and optimize the user workspaceMaintain operating system components, hardware devices, and driversCreate user and group accounts-and control rights and permissionsAdminister group policy se

Zinc recovery from the water-jacket furnace flue dusts by leaching and electrowinning in a SEC-CCS cell

CSIR Research Space (South Africa)

Mukongo, T

2009-01-01

Full Text Available electrolysis in a symmetric electrolysis current–continuous circulating system, SEC-CCS. Electrolysis current efficiency higher than 94% and 3.5 kWh/ kg of specific energy consumption was achieved under 500–600 A/m2 at 35 to 40 °C in the presence of gelatine....

Family Economic Security Policies and Child and Family Health.

Science.gov (United States)

Spencer, Rachael A; Komro, Kelli A

2017-03-01

In this review, we examine the effects of family economic security policies (i.e., minimum wage, earned income tax credit, unemployment insurance, Temporary Assistance to Needy Families) on child and family health outcomes, summarize policy generosity across states in the USA, and discuss directions and possibilities for future research. This manuscript is an update to a review article that was published in 2014. Millions of Americans are affected by family economic security policies each year, many of whom are the most vulnerable in society. There is increasing evidence that these policies impact health outcomes and behaviors of adults and children. Further, research indicates that, overall, policies which are more restrictive are associated with poorer health behaviors and outcomes; however, the strength of the evidence differs across each of the four policies. There is significant diversity in state-level policies, and it is plausible that these policy variations are contributing to health disparities across and within states. Despite increasing evidence of the relationship between economic policies and health, there continues to be limited attention to this issue. State policy variations offer a valuable opportunity for scientists to conduct natural experiments and contribute to evidence linking social policy effects to family and child well-being. The mounting evidence will help to guide future research and policy making for evolving toward a more nurturing society for family and child health and well-being.

Credit Hours with No Set Time: A Study of Credit Policies in Asynchronous Online Education

Science.gov (United States)

Prasuhn, Frederick Carl

2014-01-01

U.S. public university system policies were examined to learn how credit hours were determined for asynchronous online education. Findings indicated that (a) credit hour meaning and use are not consistent, (b) primary responsibility for credit hour decisions was at the local level, and (c) no policies exist to guide credit hour application for…

Has Technology Been Considered? A Guide for IEP Teams. CASE/TAM Assistive Technology Policy and Practice Series.

Science.gov (United States)

Chambers, A. C.

This guide compiles information essential to a working knowledge of assistive technology for children with disabilities. It addresses the definition of assistive technology and provides information on laws which direct the provision of assistive technology. The manual provides a framework to guide the Individualized Education Program (IEP) team as…

Antimalarial drug policy in India: past, present & future.

Science.gov (United States)

Anvikar, Anupkumar R; Arora, Usha; Sonal, G S; Mishra, Neelima; Shahi, Bharatendu; Savargaonkar, Deepali; Kumar, Navin; Shah, Naman K; Valecha, Neena

2014-02-01

The use of antimalarial drugs in India has evolved since the introduction of quinine in the 17 th century. Since the formal establishment of a malaria control programme in 1953, shortly after independence, treatments provided by the public sector ranged from chloroquine, the mainstay drug for many decades, to the newer, recently introduced artemisinin based combination therapy. The complexity of considerations in antimalarial treatment led to the formulation of a National Antimalarial Drug Policy to guide procurement as well as communicate best practices to both public and private healthcare providers. Challenges addressed in the policy include the use of presumptive treatment, the introduction of alternate treatments for drug-resistant malaria, the duration of primaquine therapy to prevent relapses of vivax malaria, the treatment of malaria in pregnancy, and the choice of drugs for chemoprophylaxis. While data on antimalarial drug resistance and both public and private sector treatment practices have been recently reviewed, the policy process of setting national standards has not. In this perspective on antimalarial drug policy, this review highlights its relevant history, analyzes the current policy, and examines future directions.

Public Policy and the Management of Higher Education in Sub-Saharan Africa: The Case of Kenya.

Science.gov (United States)

Gray, Kenneth R.; Credle, Sid Howard

1996-01-01

Examines Kenya's policy concerning growth and development of higher education over the last 20 years. Concludes that Kenya has problems of infrastructure quality and physical plant similar to those of other Sub-Saharan African countries, that resource allocation policies are inconsistent, and that expansion should be guided by popular demand for…

The history of South African inland fisheries policy with governance ...

African Journals Online (AJOL)

The governance of South Africa's inland fishery resources in the democratic era has lacked a guiding policy, supporting legislation and government capacity based on the social, economic and environmental objectives defined in constitutional legislation. This is ironic, as during the colonial and apartheid eras South Africa ...

secHsp70 as a tool to approach amyloid-β42 and other extracellular amyloids.

Science.gov (United States)

De Mena, Lorena; Chhangani, Deepak; Fernandez-Funez, Pedro; Rincon-Limas, Diego E

2017-07-03

Self-association of amyloidogenic proteins is the main pathological trigger in a wide variety of neurodegenerative disorders. These aggregates are deposited inside or outside the cell due to hereditary mutations, environmental exposures or even normal aging. Cumulative evidence indicates that the heat shock chaperone Hsp70 possesses robust neuroprotection against various intracellular amyloids in Drosophila and mouse models. However, its protective role against extracellular amyloids was largely unknown as its presence outside the cells is very limited. Our recent manuscript in PNAS revealed that an engineered form of secreted Hsp70 (secHsp70) is highly protective against toxicity induced by extracellular deposition of the amyloid-β42 (Aβ42) peptide. In this Extra View article, we extend our analysis to other members of the heat shock protein family. We created PhiC31-based transgenic lines for human Hsp27, Hsp40, Hsp60 and Hsp70 and compared their activities in parallel against extracellular Aβ42. Strikingly, only secreted Hsp70 exhibits robust protection against Aβ42-triggered toxicity in the extracellular milieu. These observations indicate that the ability of secHsp70 to suppress Aβ42 insults is quite unique and suggest that targeted secretion of Hsp70 may represent a new therapeutic approach against Aβ42 and other extracellular amyloids. The potential applications of this engineered chaperone are discussed.

Green electricity buyer's guide

International Nuclear Information System (INIS)

Kelly, B.; Klein, S.; Olivastri, B.

2002-06-01

The electricity produced in whole or in large part from renewable energy sources like wind, small hydro electricity and solar energy, is generally referred to as green electricity. The authors designed this buyer's guide to assist customers in their understanding of green electricity, as the customers can now choose their electricity supplier. The considerations and steps involved in the purchasse of green electricity are identified, and advice is provided on ways to maximize the benefits from the purchase of green electricity. In Alberta and Ontario, customers have access to a competitive electricity market. The emphasis when developing this guide was placed firmly on the large buyers, as they can have enormous positive influence on the new market for green electricity. The first chapter of the document provides general information on green electricity. In chapter two, the authors explore the opportunity for environmental leadership. Chapter three reviews the basics of green electricity, which provides the link to chapter four dealing with the creation of a policy. Purchasing green electricity is dealt with in Chapter five, and maximizing the benefits of green electricity are examined in Chapter Six. 24 refs., 3 tabs

Policies to promote on physical activity and healthy eating in kindergartens from theory to practice

DEFF Research Database (Denmark)

Mikkelsen, Bent Egberg

2011-01-01

Accumulating evidence shows that there seems to be a relation between the existence of a policy and at least some health behaviours of children. The purpose of this paper is to give a brief account of the value of policy as a tool that can be used at local level to guide action to promote healthy...

Metabolism of the insecticidally active GABAA receptor antagonist 4-sec-[3,4-3H2]butyl-1-(4-cyanophenyl)-2,6,7-trioxabicyclo[2.2.2]octane

International Nuclear Information System (INIS)

Deng, Yanli; Palmer, C.J.; Toia, R.F.; Casida, J.E.

1990-01-01

4-sec-[3,4- 3 H 2 ]Butyl-1-(4-cyanophenyl)-2,6,7-trioxabicyclo[2.2.2]octane (referred to as [ 3 H]COB) was examined as an example of a new class of insecticidally active compounds that block the γ-aminobutyric acid gated chloride channel. Metabolites were identified by thin-layer cochromatography with standards from synthesis and by consideration of their hydrolytic and oxidative degradation products formed in situ on two-dimensional silica gel chromatoplates. Metabolism of [ 3 H]COB by mouse liver and housefly abdomen microsomes is dependent on fortification with NADPH. The O-methylene and sec-butyl sites are sensitive to oxidation. Each carbon of the sec-butyl group is individually functionalized with strong preference for the methylene site in the mouse but not the housefly microsomal system. O-Methylene hydroxylation initiates spontaneous cage opening to form an aldehyde that undergoes metabolic reduction, ultimately yielding the same cyanobenzoate ester of 2,2-bis-(hydroxymethyl)-3-methylpentan-1-ol formed by direct hydrolysis. Houseflies injected with [ 3 H]COB form many if not all of the same metabolites, with major products being the aforementioned cyanobenzoate, the orthoester oxidized at the sec-butyl methylene site, and polar conjugates

Environmental policy - a diaspora for market economists

Energy Technology Data Exchange (ETDEWEB)

Endres, A.

1987-03-01

The environmental policy of the Federal Republic of Germany still leaves more than enough room for the implementation of marketing elements. With the help of evaluation processes borrowed from the market mechanism all those in search of appropriate environmental policies are able to better analyse the very priorities they have made their aim. Democratic decision making should make it a point to see to the integration of information gained on the preferences of the citizen. Market-analogous evaluation processes currently seem about to be given a better chance. The vehicles of environmental policy are obviously suffering even more from a suppressed demand for market impulses. In the Federal Republic of Germany environmental vehicles generally tend to be lead and determined by regulations. For the benefit of economy and the environment data and certificates (or compensatory regulations) could be combined much more than before with the traditional regulation-oriented policy. For the time being chances seem to be poor for completions to come in from the market. The revised Clean Air Technical Guide (TA Luft) has wasted a promising chance. (orig./HSCH).

A novel method for feasibility testing urban sustainable development policies

Directory of Open Access Journals (Sweden)

O’Doherty Travis

2013-01-01

Full Text Available Policy making to promote more sustainable development is a complex task due in part to the large number of both stakeholders and potential policies. Policy feasibility testing provides a guide to the viability and practicality of policy implementation and forms an important part of an evidence based policy making process. An extensive literature review has identified no standardized approach to feasibility testing. This paper addresses this knowledge gap by describing a novel method using Multi-Criteria Decision Analysis (MCDA for feasibility testing of policies aimed at increasing the sustainability of towns and villages in Ireland. Feasibility results are provided for 40 frequently cited policy interventions tested for 18 settlements in Ireland. Policies were selected in the arenas of transport, food, housing and urban form, energy, waste and water. Policies are feasibility tested through analysis of operational evidence from both quantitative and qualitative data sources. Following testing, policies are ranked in terms of feasibility. This research examines the effectiveness of local and national level policies and the importance of both local community involvement and central government regulation in policy success. The inter-settlement variation in feasibility testing scores prioritises policy selection and aims to reduce cherry-picking of policies to support the viewpoints of the decision maker. Although developed for an Irish urban context the methods described here may have applicability elsewhere.

Logic problems and solutions for memory signal of SEC pump in FQNP

International Nuclear Information System (INIS)

Lu Yanfei; Dang Xiaoqiang; Zhou Li; Ye Aiai

2014-01-01

In the Fuqing nuclear power plant, as a nuclear safety function system, the essential service water system is set two trains, and there are two pumps in each train. These pumps can be switched automatically according to the operation conditions. The signal which performs the automatic switch function called memory signal. This paper introduces the definition and role of the memory signal firstly, and then analyzes the logic of the two mutual backup SEC pumps, and the implementation method based on DCS platform. Finally, this paper presents the problems of memory signal during the commissioning and operation. Meanwhile, this paper proposes solutions to solve these problems, and analyzes the risk of the solutions, as well the significance for later units. (authors)

Application of SEC-ICP-MS for comparative analyses of metal-containing species in cancerous and healthy human thyroid samples.

Science.gov (United States)

Boulyga, Sergei F; Loreti, Valeria; Bettmer, Jörg; Heumann, Klaus G

2004-09-01

Size exclusion chromatography (SEC) was coupled on-line to inductively coupled plasma mass spectrometry (ICP-MS) for speciation study of trace metals in cancerous thyroid tissues in comparison to healthy thyroids aimed to estimation of changes in metalloprotein speciation in pathological tissue. The study showed a presence of species binding Cu, Zn, Cd and Pb in healthy thyroid tissue with a good reproducibility of chromatographic results, whereas the same species could not be detected in cancerous tissues. Thus, remarkable differences with respect to metal-binding species were revealed between healthy and pathological thyroid samples, pointing out a completely different distribution of trace metals in cancerous tissues. The metal-binding species could not be identified in the frame of this work because of a lack of appropriate standards. Nevertheless, the results obtained confirm the suitability of SEC-ICP-MS for monitoring of changes in trace metal distribution in cancerous tissue and will help to better understand the role of metal-containing species in thyroid pathology.

Nucleonics, and nuclear matter in 10-20 secs. before the close of open-quotes Big Bangclose quotes

International Nuclear Information System (INIS)

Ayub, S.M.

1995-01-01

The Nuclear picture 10 -20 secs. after the thermonuclear creation of the Universe ∼8 Billion years ago (as also evidenced by Hubble Telescope) was published. Relativity concepts predict the Nuclear picture l0 -20 secs. before the open-quote G close-quote collapse of the Universe, by the progressive decline of expansion,and H. Constant. No double-nuclei, anymore. Only Neutrinos, as predicted by International Scientists, and fragments of Black Holes. Universe open-quote r close-quote=60 Billion Light-Years. At the Zero Point, N.Force,and 3 other Forces merging into Super-G. Time, Space, becoming identical, and all Physical Laws vanishing. The final will be Nuclear Matter compact of ∼ 10Km., open-quote r close-quote, P=10 15 -10 18 Temp. > 10 10 Deg. C. P> 10 18 will cause another thermonuclear Bang'. Super-computers, also, cannot predict beyond this point. There will be the Creator, and a compact of Nuclear Matter. In the absence of Physical Laws, there can be no further predictability. What initiated by the N. Force, has culminated into a compact of Nuclear Matter- - how interesting exclamation point

Do Latin American scientific journals follow dual-use review policies?

Science.gov (United States)

Valles, Edith Gladys; Bernacchi, Adriana Silvina

2014-01-01

During the past decade, a number of journals have implemented dual-use policies in order to analyze whether the papers submitted for publication could raise concern because of the potential for misuse of their content. In this context, an analysis was performed on Latin American scientific journals to examine whether they apply formal written dual-use review policies and whether they inform their authors and reviewers about potentially sensitive issues in this area, as other international journals do. Peer-reviewed life sciences journals indexed in Latindex from Brazil, Mexico, Argentina, and Chile were analyzed. The Guide for Authors and the Instructions to Referees of 216 journals included in the Latindex catalogue (which means that they meet the best quality standards of the Latindex system) were screened for biosecurity-related information using the keywords biosecurity, biological weapons, and dual-use research of concern. Results showed that the screened publications had a total lack of dual-use review policies, even though some of them pointed out ethical behaviors to be followed related to authorship, plagiarism, simultaneous submission, research results misappropriation, ethical principles for medical research involving human subjects, guiding principles for the care and use of animals in research, research standard violations, and reviewer bias, among others.

Health care in Canada: a citizen's guide to policy and politics

National Research Council Canada - National Science Library

Fierlbeck, Katherine

2011-01-01

... outlines the basic framework of the health care system with reference to speci fi c areas such as administration and governance, public health, human resources, drugs and drug policy, and mental health. She also discusses alternative models in other countries such as Britain, the United States, and France. As health care becomes increasingly complex...

Cross sections and neutron yields for U233, U235 and Pu239 at 2200 m/sec

International Nuclear Information System (INIS)

Sjoestrand, N.G.; Story, J.S.

1960-04-01

The experimental information on the 2200 m/sec values for σ abs , σ f , α, ν and η for 233 U , 235 U and 23 been collected and discussed. The values will later be used in an evaluation of a 'best' set of data. In appendix the isotopic abundances of the uranium isotopes are discussed and also the alpha activities of the uranium isotopes and Pu-239

Urban distribution by electric transport. A guide for municipalities. 2013; Stedelijke distributie met elektrisch vervoer. Een gids voor gemeenten. 2013

Energy Technology Data Exchange (ETDEWEB)

NONE

2013-10-15

This guide provides practical tools for municipalities in the Netherlands to develop and implement policies for urban distribution by electric transport (a.k.a. e-distribution). The guide highlights the different roles that municipalities can play to promote electric mobility. The guide also describes the policies and measures that fit these roles. Further, practical experiences and examples give a clear picture of present activities of municipalities and entrepreneurs in this field [Dutch] Deze gids biedt gemeenten praktische handvatten om beleid te ontwikkelen en uit te voeren voor stedelijke distributie met elektrisch vervoer (e-distributie). De gids belicht de verschillende rollen die gemeenten kunnen vervullen om elektrisch vervoer te bevorderen. Ook beschrijft de gids de beleidskeuzen en maatregelen die bij deze rollen passen. Verder geven praktijkervaringen en voorbeelden een duidelijk beeld van wat gemeenten en ondernemers doen die al op dit terrein actief zijn.

The definitive guide to the C&A transformation process

CERN Document Server

Mehan, Julie E

2009-01-01

'The Definitive Guide to the C&A Transformation' is the first comprehensive manual that sets out to explain the current standards and best practices. The book provides all the information needed to recognize, implement and manage the relevant authorization requirements, and therefore to achieve compliance with federal, local and agency laws and policies. Each chapter not only provides a list of related references but also offers recommendations for additional reading.

South African tourism: An historic evaluation of macro tourism policies

African Journals Online (AJOL)

... namely Rugby, Cricket and Soccer, and numerous other sporting, cultural and business events have successfully been hosted in the country. Macro policies governing tourism at the national level have been introduced to stimulate and guide tourism growth in such a way that the public at large can benefit. Furthermore ...

The relationship between sun protection policies and practices in schools with primary-age students: the role of school demographics, policy comprehensiveness and SunSmart membership.

Science.gov (United States)

Dono, J; Ettridge, K A; Sharplin, G R; Wilson, C J

2014-02-01

Schools can implement evidence-based sun protection policies that guide practices to help protect children from harmful sun exposure. This national study assessed the relationship between the existence and comprehensiveness of written policies and the comprehensiveness of sun protection practices. The impact of school demographics on the strength of the relationship was also examined, as was the possibility that 'SunSmart' membership would have an additional impact on practices, beyond having any formal policy. In 2011-12, staff members of 1573 schools catering to primary-age students completed a self-administered survey about sun protection policies and practices (response rate of 57%). Results showed that schools with a written policy had more comprehensive practices than schools without a written policy. The relationship between having a written policy and sun protection practices was stronger for remote schools compared with metropolitan and regional schools, and for schools catering to both primary and secondary students compared with primary students only. In addition, policy comprehensiveness was associated with practice comprehensiveness, and SunSmart membership was indirectly related to practice comprehensiveness via policy comprehensiveness. These results indicate that written policies relate to practice comprehensiveness, but the strength of the association can vary according to the characteristics of the organization.

Isotope effects and the temperature dependences of the hyperfine coupling constants of muoniated sec-butyl radicals in condensed phases.

Science.gov (United States)

Fleming, Donald G; Bridges, Michael D; Arseneau, Donald J; Chen, Ya Kun; Wang, Yan Alexander

2011-04-07

Reported here is the first μSR study of the muon (A(μ)) and proton (A(p)) β-hyperfine coupling constants (Hfcc) of muoniated sec-butyl radicals, formed by muonium (Mu) addition to 1-butene and to cis- and trans-2-butene. The data are compared with in vacuo spin-unrestricted MP2 and hybrid DFT/B3YLP calculations reported in the previous paper (I), which played an important part in the interpretation of the data. The T-dependences of both the (reduced) muon, A(μ)′(T), and proton, A(p)(T), Hfcc are surprisingly well explained by a simple model, in which the calculated Hfcc from paper I at energy minima of 0 and near ±120° are thermally averaged, assuming an energy dependence given by a basic 2-fold torsional potential. Fitted torsional barriers to A(μ)′(T) from this model are similar (~3 kJ/mol) for all muoniated butyl radicals, suggesting that these are dominated by ZPE effects arising from the C−Mu bond, but for A(p)(T) exhibit wide variations depending on environment. For the cis- and trans-2-butyl radicals formed from 2-butene, A(μ)′(T) exhibits clear discontinuities at bulk butene melting points, evidence for molecular interactions enhancing these muon Hfcc in the environment of the solid state, similar to that found in earlier reports for muoniated tert-butyl. In contrast, for Mu−sec-butyl formed from 1-butene, there is no such discontinuity. The muon hfcc for the trans-2-butyl radical are seemingly very well predicted by B3LYP calculations in the solid phase, but for sec-butyl from 1-butene, showing the absence of further interactions, much better agreement is found with the MP2 calculations across the whole temperature range. Examples of large proton Hfcc near 0 K are also reported, due to eclipsed C−H bonds, in like manner to C−Mu, which then also exhibit clear discontinuities in A(p)(T) at bulk melting points. The data suggest that the good agreement found between theory and experiment from the B3LYP calculations for eclipsed bonds in

Can a 15-sec FLAIR replace conventional FLAIR sequence in stroke MR protocols?

Science.gov (United States)

Benzakoun, J; Maïer, B; Calvet, D; Edjlali, M; Turc, G; Lion, S; Legrand, L; Ben Hassen, W; Naggara, O; Meder, J F; Mas, J L; Oppenheim, C

2017-06-01

Triage imaging facilitates the timely recognition of acute stroke with prognostic implications. Improvement in MR acquisition speed is needed given the extreme time constraints before treatment. We compared an ultrafast Echo-Planar FLAIR sequence (EPI-FLAIR) and a conventional FLAIR sequence (cFLAIR) for their diagnostic performances and ability to estimate the age of infarction. Between June and August 2014, 125 consecutive patients (age 69±18 years, 48% men) admitted for a suspicion of acute (≤48-hrs) stroke were explored by both FLAIR sequences at 1.5-Tesla. EPI-FLAIR (15-sec) and cFLAIR (2-min and 15-sec) were compared by two readers, blinded to clinical data. EPI-FLAIR was less prone to kinetic artefacts than cFLAIR (2-3% vs. 23-49% depending on the reader, P0.9). Amongst 8 hemorrhages, one subarachnoid hemorrhage presenting as a sudden deficit was missed on EPI-FLAIR sequence. Amongst 60 infarctions, cFLAIR and EPI-FLAIR were concordant in 50 (83%), while signal changes were visible on cFLAIR only in the remaining 10 (17%) cases. Amongst the 43 patients with known onset time (n=17 within 4.5hrs), FLAIR-DWI mismatch identified<4.5-hrs infarction with the same sensitivity (65%) using cFLAIR and EPI-FLAIR, but the positive predictive value (PPV) was higher for cFLAIR than for EPI-FLAIR (73% vs. 50%, P=0.008). EPI-FLAIR allows a drastic reduction of acquisition time devoted to FLAIR sequence and minimizes motion artifacts. Compared with cFLAIR, it is however associated with increased risk of undiagnosed stroke mimics and lower PPV for identifying<4.5-hrs infarctions. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

Finding Funding: A Guide to Federal Sources for Youth Programs. Finding Funding Series

Science.gov (United States)

Dobbins-Harper, Dionne; Bhat, Soumya

2007-01-01

This publication is part of a series of tools and resources on financing and sustaining youth programming. These tools and resources are intended to help policymakers, program developers, and community leaders develop innovative strategies for implementing, financing, and sustaining effective programs and policies. This guide outlines strategies…

Adjusting policy to institutional, cultural and biophysical context conditions: The case of conservation banking in California

Science.gov (United States)

Carsten Mann; James D. Absher

2013-01-01

This paper examines the political construction of a policy instrument for matching particular institutional, biophysical and cultural context conditions in a social–ecological system, using the case of conservation banking in California as an example. The guiding research question is: How is policy design negotiated between various actors on its way from early...

Upending the social ecological model to guide health promotion efforts toward policy and environmental change.

Science.gov (United States)

Golden, Shelley D; McLeroy, Kenneth R; Green, Lawrence W; Earp, Jo Anne L; Lieberman, Lisa D

2015-04-01

Efforts to change policies and the environments in which people live, work, and play have gained increasing attention over the past several decades. Yet health promotion frameworks that illustrate the complex processes that produce health-enhancing structural changes are limited. Building on the experiences of health educators, community activists, and community-based researchers described in this supplement and elsewhere, as well as several political, social, and behavioral science theories, we propose a new framework to organize our thinking about producing policy, environmental, and other structural changes. We build on the social ecological model, a framework widely employed in public health research and practice, by turning it inside out, placing health-related and other social policies and environments at the center, and conceptualizing the ways in which individuals, their social networks, and organized groups produce a community context that fosters healthy policy and environmental development. We conclude by describing how health promotion practitioners and researchers can foster structural change by (1) conveying the health and social relevance of policy and environmental change initiatives, (2) building partnerships to support them, and (3) promoting more equitable distributions of the resources necessary for people to meet their daily needs, control their lives, and freely participate in the public sphere. © 2015 Society for Public Health Education.

Phospho-Rasputin Stabilization by Sec16 Is Required for Stress Granule Formation upon Amino Acid Starvation

OpenAIRE

Aguilera-Gomez, Angelica; Zacharogianni, Margarita; van Oorschot, Marinke M; Genau, Heide; Grond, Rianne; Veenendaal, Tineke; Sinsimer, Kristina S; Gavis, Elizabeth R; Behrends, Christian; Rabouille, Catherine

2017-01-01

Most cellular stresses induce protein translation inhibition and stress granule formation. Here, using Drosophila S2 cells, we investigate the role of G3BP/Rasputin in this process. In contrast to arsenite treatment, where dephosphorylated Ser142 Rasputin is recruited to stress granules, we find that, upon amino acid starvation, only the phosphorylated Ser142 form is recruited. Furthermore, we identify Sec16, a component of the endoplasmic reticulum exit site, as a Rasputin interactor and sta...

Expressions of agency within complex policy structures: science teachers' experiences of education policy reforms in Sweden

Science.gov (United States)

Ryder, Jim; Lidar, Malena; Lundqvist, Eva; Östman, Leif

2018-03-01

We explore the experiences of school science teachers as they enact three linked national curriculum and assessment policy reforms in Sweden. Our goal is to understand teachers' differing responses to these reforms. A sample of 13 teachers engaged in 2 interviews over a 6-9-month period. Interviews included exploration of professional background and school context, perceptions of the aims of the policy reforms and experiences of working with these reforms in the classroom. Analysis was guided by an individual-oriented sociocultural perspective on professional agency. Here teaching is conceptualised as an ongoing interplay between teachers' knowledge, skills and personal goals, and the characteristics of the social, institutional and policy settings in which they work. Our analysis shows that navigating the ensuing continuities and contradictions results in many different expressions of teacher agency, e.g. loss of autonomy and trust, pushing back, subversion, transfer of authority, and creative tensions. Typically, an individual teacher's enactment of these reforms involved several of these expressions of agency. We demonstrate that the sociocultural perspective provides insights into teachers' responses to education policy reform likely to be missed by studies that focus largely on individual teacher knowledge/beliefs about reform or skills in 'implementing' reform practices.

Development of school energy policy and energy education plans: A comparative case study in three Wisconsin school communities

International Nuclear Information System (INIS)

Lane, Jennie F.; Floress, Kristin; Rickert, Melissa

2014-01-01

Through a qualitative comparative case study, this investigation examined the process by which three school districts in Wisconsin, U.S.A., developed a school energy policy and complementary energy education plan. To guide the process, the researchers created an outline of recommended steps for the districts to follow. Although there were variations in the sequence and perceived ease of the steps, the Energy Task Force members involved in the process found the outline to be a supportive guide. Further analysis of the cases involved interviewing members of the Energy Task Forces to identify facilitating and obstructing factors. The study concluded that factors such as level of environmental literacy, along with aspects of the school culture and leadership, interacted to influence the successful drafting of school energy policies and education plans. In addition to introducing an outline of recommended steps that can be used by other school policy development teams interested in promoting energy efficiency, this study adds insights into the analysis of energy policy work within the context of a school setting. - Highlights: • School energy policy and complementary energy education plans can be successfully developed with guidelines for policy team membership. • Teacher agency, including environmental literacy, helps overcome barriers in developing school policy and energy education plans. • Administrative support of energy conservation is a key to the development of school energy policies and complementary energy education plans

Family Grant: social policy or political marketing?

Directory of Open Access Journals (Sweden)

Paulo Gabriel Martins de Moura

2007-04-01

Full Text Available This essay, a political analysis, criticizes the Family Grant Program, implemented by the Lula government of 2003-2005. It is based on the ongoing analysis methodology originated in U.S. political science. It seeks to establish a parallel of these analyses with criticisms of the Family Grant program presented in the media and made by specialists. They focus on the absence of a conceptual reference for the program (or its practical non-application, supported by accumulated knowledge in the field, that would guide the social policies of the Lula government. Based on secondary sources about official data and on statements from specialists, the analysis identifies an apparent 'schizophrenia' in the 'philosophical' references that orient the government's social policies, suggesting that the solution chosen was a situational response to a demand for government marketing and not oriented to a deliberate public policy pre-conceived as such, which, if it exists, is not evident in the government actions.

Science Under Attack! Public Policy, Science Education, and the Emperor's New Clothes

Energy Technology Data Exchange (ETDEWEB)

Krauss, Lawrence (Case Western Reserve University)

2005-12-05

The popular debate about the teaching of intelligent design in public schools is but one quandary for scientists and policy makers. Given recent developments which have worked to breed a general distrust of science, it is evident that researchers and politicians alike should be wary of using popular opinion as a guide for policy and pedagogy when it comes to science in public education. Dr. Krauss will qualify this complex issue and will address how educators, policy makers and scientists can work effectively to prevent public misconceptions of science.

[Review of food policy approaches: from food security to food sovereignty (2000-2013)].

Science.gov (United States)

López-Giraldo, Luis Alirio; Franco-Giraldo, Álvaro

2015-07-01

Food policies have attracted special interest due to the global food crisis in 2008 and promotion of the Millennium Development Goals, leading to approaches by different fields. This thematic review aims to describe the main theoretical and methodological approaches to food security and food sovereignty policies. A search was performed in databases of scientific journals from 2000 to 2013. 320 complete articles were selected from a total of 2,699. After reading the articles to apply the inclusion criteria, 55 items were maintained for analysis. In conclusion, with the predominance of food security as a guiding policy, food sovereignty has emerged as a critical response to be included in designing and researching food policies. Food policies are essential for achieving public health goals. Public health should thus take a leading role in linking and orienting such policies.

Urban residents' response to and evaluation of low-carbon travel policies: Evidence from a survey of five eastern cities in China.

Science.gov (United States)

Geng, Jichao; Long, Ruyin; Chen, Hong; Li, Qianwen

2018-03-24

To address the problems of excessive energy consumption and global climate change, the Chinese government has issued numerous policies to guide urban residents' low-carbon travel behavior. To evaluate the validity of these policies from the perspective of public opinion, this study summarizes 22 policies from the four vantage points of economics, administration, technology, and public information and then measures residents' response to and evaluation of policies based on survey data on 1977 urban residents using stratified random sampling in five cities in eastern China. The results indicate that from the viewpoint of policy response, administrative policies for promoting public transport show the highest degree of response, followed by public information, technological, and economic policies. Specifically, the responses to parking and congestion fee policies are relatively stronger than those to vehicle purchase tax, vehicle and vessel tax, and fuel surcharge policies. Moreover, the responses to fuel surcharge policy are even weaker than car-restriction policies, including license-plate number restriction, license-plate lottery, and license-plate auction policies. From the viewpoint of policy evaluation, administrative policies for promoting public transport obtain the highest evaluations, followed by economic and technological policies. Residents' evaluations of car-restriction and public information policies are the lowest. In addition, a four-paradigm model is introduced to illustrate residents' reactions to each policy in terms of response and evaluation. Finally, several implementation strategies, including the anterior, concurrent, optional, core, supporting, and assisting policy options are proposed to guide urban residents' low-carbon travel behavior. Copyright © 2018 Elsevier Ltd. All rights reserved.

Antimalarial drug policy in India: Past, present & future

Directory of Open Access Journals (Sweden)

Anupkumar R Anvikar

2014-01-01

Full Text Available The use of antimalarial drugs in India has evolved since the introduction of quinine in the 17 th century. Since the formal establishment of a malaria control programme in 1953, shortly after independence, treatments provided by the public sector ranged from chloroquine, the mainstay drug for many decades, to the newer, recently introduced artemisinin based combination therapy. The complexity of considerations in antimalarial treatment led to the formulation of a National Antimalarial Drug Policy to guide procurement as well as communicate best practices to both public and private healthcare providers. Challenges addressed in the policy include the use of presumptive treatment, the introduction of alternate treatments for drug-resistant malaria, the duration of primaquine therapy to prevent relapses of vivax malaria, the treatment of malaria in pregnancy, and the choice of drugs for chemoprophylaxis. While data on antimalarial drug resistance and both public and private sector treatment practices have been recently reviewed, the policy process of setting national standards has not. In this perspective on antimalarial drug policy, this review highlights its relevant history, analyzes the current policy, and examines future directions.

Science Education & Advocacy: Tools to Support Better Education Policies

Science.gov (United States)

O'Donnell, Christine; Cunningham, B.; Hehn, J. G.

2014-01-01

Education is strongly affected by federal and local policies, such as testing requirements and program funding, and many scientists and science teachers are increasingly interested in becoming more engaged with the policy process. To address this need, I worked with the American Association of Physics Teachers (AAPT) --- a professional membership society of scientists and science teachers that is dedicated to enhancing the understanding and appreciation of physics through teaching --- to create advocacy tools for its members to use, including one-page leave-behinds, guides for meeting with policymakers, and strategies for framing issues. In addition, I developed a general tutorial to aid AAPT members in developing effective advocacy strategies to support better education policies. This work was done through the Society for Physics Students (SPS) Internship program, which provides a range of opportunities for undergraduates, including research, education and public outreach, and public policy. In this presentation, I summarize these new advocacy tools and their application to astronomy education issues.

California's response to the Low-Level Radioactive Waste Policy Act of 1980: policy and progress

International Nuclear Information System (INIS)

Pasternak, A.D.

1985-01-01

The public and private corporations and institutions in California that use radioactive materials and generate low-level radioactive waste have played a major role in shaping and guiding California's response to the federal Low-Level Radioactive Waste Policy Act of 1980. Working together as the California Radioactive Materials Management Forum (CAL RAD FORUM), these organizations carry out legislative and public education programs with the objective of establishing, in California, a low-level radioactive waste disposal facility and maintaining access to existing disposal facilities in other states until the California facility is licensed and operating

COATING ALTERNATIVES GUIDE (CAGE) USER'S GUIDE

Science.gov (United States)

The guide provides instructions for using the Coating Alternatives GuidE (CAGE) software program, version 1.0. It assumes that the user is familiar with the fundamentals of operating an IBM-compatible personal computer (PC) under the Microsoft disk operating system (MS-DOS). CAGE...

The Greening of Innovation Systems for Eco-innovation - Towards an Evolutionary Climate Mitigation Policy

DEFF Research Database (Denmark)

Andersen, Maj Munch; Foxon, Timothy J.

2009-01-01

Policies for mitigating climate change have never received as much attention worldwide as now. At the same time another upcoming policy trend is the increasing synthesis between innovation- and environmental policy, a synthesis that is captured by the “eco-innovation” concept. However, the climate...... and innovation policy areas are currently little aligned and have in fact been considered “opposites” until very recently. The paper seeks to identify how evolutionary economic theory, hitherto very little applied to the environmental area, may guide the development of climate policies and eco...... implications of this shift are considerable and have hitherto gained little attention. A deeper understanding of eco-innovation dynamics is strongly needed for informing both climate and innovation policies. The paper argues that the fact that environmental problems have largely been neglected by evolutionary...

Towards improved policy processes for promoting innovation in renewable electricity technologies in the UK

International Nuclear Information System (INIS)

Foxon, T.J.; Pearson, P.J.G.

2007-01-01

This paper analyses recent, current and potential future relations between policy processes and substantive outcomes in UK low carbon innovation policy, focussing on policies relating to renewable electricity generation technologies. It examines the development of policy processes relating to the adoption and implementation of the Renewables Obligation and how these may affect the current and likely future success of the Obligation in promoting low carbon innovation. It examines the new policy and institutional processes put in place in the 2003 Energy White Paper and argues that these are unlikely to provide the strategic long-term framework needed to realise the ambitious goals for UK energy policy set out in the White Paper. Finally, it outlines some suggestions for further development of policy processes to facilitate improved delivery of these goals, based on guiding principles for sustainable innovation policy processes, developed by the authors and their colleagues

Endovascular MR-guided Renal Embolization by Using a Magnetically Assisted Remote-controlled Catheter System.

Science.gov (United States)

Lillaney, Prasheel V; Yang, Jeffrey K; Losey, Aaron D; Martin, Alastair J; Cooke, Daniel L; Thorne, Bradford R H; Barry, David C; Chu, Andrew; Stillson, Carol; Do, Loi; Arenson, Ronald L; Saeed, Maythem; Wilson, Mark W; Hetts, Steven W

2016-10-01

Purpose To assess the feasibility of a magnetically assisted remote-controlled (MARC) catheter system under magnetic resonance (MR) imaging guidance for performing a simple endovascular procedure (ie, renal artery embolization) in vivo and to compare with x-ray guidance to determine the value of MR imaging guidance and the specific areas where the MARC system can be improved. Materials and Methods In concordance with the Institutional Animal Care and Use Committee protocol, in vivo renal artery navigation and embolization were tested in three farm pigs (mean weight 43 kg ± 2 [standard deviation]) under real-time MR imaging at 1.5 T. The MARC catheter device was constructed by using an intramural copper-braided catheter connected to a laser-lithographed saddle coil at the distal tip. Interventionalists controlled an in-room cart that delivered electrical current to deflect the catheter in the MR imager. Contralateral kidneys were similarly embolized under x-ray guidance by using standard clinical catheters and guidewires. Changes in renal artery flow and perfusion were measured before and after embolization by using velocity-encoded and perfusion MR imaging. Catheter navigation times, renal parenchymal perfusion, and renal artery flow rates were measured for MR-guided and x-ray-guided embolization procedures and are presented as means ± standard deviation in this pilot study. Results Embolization was successful in all six kidneys under both x-ray and MR imaging guidance. Mean catheterization time with MR guidance was 93 seconds ± 56, compared with 60 seconds ± 22 for x-ray guidance. Mean changes in perfusion rates were 4.9 au/sec ± 0.8 versus 4.6 au/sec ± 0.6, and mean changes in renal flow rate were 2.1 mL/min/g ± 0.2 versus 1.9 mL/min/g ± 0.2 with MR imaging and x-ray guidance, respectively. Conclusion The MARC catheter system is feasible for renal artery catheterization and embolization under real-time MR imaging in vivo, and quantitative physiologic

THE SECULAR INFLUENCE OF THE RATE OF REFERENCE ON THE ECONOMIC POLICIES

Directory of Open Access Journals (Sweden)

Emilian M.DOBRESCU

2005-12-01

Full Text Available Having as starting point Radu Stoenescu’s book with respect to discount, and the difficulty in defining discount, we pursue to clarify this category and other associated ones, such as reference rate, discount rate, re-discount and its rate, in a historical and actual approach. The purpose is to demonstrate that the monetary policy about discount influences the economic policies and that is why it must be altered and guided in accordance with the changes of current economic-financial activity.

THE SECULAR INFLUENCE OF THE RATE OF REFERENCE ON THE ECONOMIC POLICIES

OpenAIRE

Emilian M.DOBRESCU

2005-01-01

Having as starting point Radu Stoenescu’s book with respect to discount, and the difficulty in defining discount, we pursue to clarify this category and other associated ones, such as reference rate, discount rate, re-discount and its rate, in a historical and actual approach. The purpose is to demonstrate that the monetary policy about discount influences the economic policies and that is why it must be altered and guided in accordance with the changes of current economic-financial activity.

Promotion Guide – A guide for career reviews

CERN Multimedia

Staff Association

2017-01-01

On 8 February, the Standing Concertation Committee (SCC) approved the Promotion Guide, subtitled “A guide for career reviews”. The English version is already published on the HR website. This Promotion Guide is not very different from the Career Path Guide which it replaces following the implementation of the new career structure with benchmark jobs and grades. Structure The guide is composed of three parts: Section I – Introduction revisits the reference documents: the Staff Rules and Regulations (S&R) and the Administrative Circular No. 26 (AC 26). In the Staff Rules and Regulations, the term promotion is defined as a change of grade1 and in Administrative Circular No. 26, the Promotion Guide is referenced under paragraph 452. The objective of the Promotion Guide is laid out in Section I: “The Promotion Guide defines the criteria to be used as a reference for career reviews with a view to a potential promotion”. However, this guide do...

Enhanced labelling on alcoholic drinks: reviewing the evidence to guide alcohol policy.

Science.gov (United States)

Martin-Moreno, Jose M; Harris, Meggan E; Breda, Joao; Møller, Lars; Alfonso-Sanchez, Jose L; Gorgojo, Lydia

2013-12-01

Consumer and public health organizations have called for better labelling on alcoholic drinks. However, there is a lack of consensus about the best elements to include. This review summarizes alcohol labelling policy worldwide and examines available evidence to support enhanced labelling. A literature review was carried out in June-July 2012 on Scopus using the key word 'alcohol' combined with 'allergens', 'labels', 'nutrition information', 'ingredients', 'consumer information' and/or 'warning'. Articles discussing advertising and promotion of alcohol were excluded. A search through Google and the System for Grey Literature in Europe (SIGLE) identified additional sources on alcohol labelling policies, mainly from governmental and organizational websites. Five elements were identified as potentially useful to consumers: (i) a list of ingredients, (ii) nutritional information, (iii) serving size and servings per container, (iv) a definition of 'moderate' intake and (v) a health warning. Alcohol labelling policy with regard to these aspects is quite rudimentary in most countries, with few requiring a list of ingredients or health warnings, and none requiring basic nutritional information. Only one country (Australia) requires serving size and servings per container to be displayed. Our study suggests that there are both potential advantages and disadvantages to providing consumers with more information about alcohol products. Current evidence seems to support prompt inclusion of a list of ingredients, nutritional information (usually only kcal) and health warnings on labels. Standard drink and serving size is useful only when combined with other health education efforts. A definition of 'moderate intake' and recommended drinking guidelines are best suited to other contexts.

Balloon observation of the binary X-ray source Her X-1 1.24 sec pulsation and cyclotron line emission

International Nuclear Information System (INIS)

Pietsch, W.; Reppin, C.; Truemper, J.; Voges, W.; Kendziorra, E.; Staubert, R.; Tuebingen Univ.

1978-01-01

During a balloon observation from Palestine, Texas, the authors detected for the first time the 1.24 sec pulsation of Hercules X-1 in the hard X-ray range up to 70 keV and discovered strong line emission in its spectrum at 58 keV. They estimated a line flux of 3x10 -3 photons cm -2 sec -1 and a line width of less than 12 keV. The phenomenon is interpreted as electron cyclotron emission at the basic frequency emitted by the hot polar plasma of the rotating neutron star. The line measured leads to a magnetic field strength of 5.3x10 12 gauss. In further observations during a balloon campaign in Sept./Oct. 1977 the authors confirmed the existence of the line emission and for the first time found pulsed X-ray emission above 15 keV during the 'short on' - and 'off'-state of the Her X-1 35 day cycle. The pulse to interpulse ratio seems to vary with the 35 day phase

Malaria treatment policy change and implementation: the case of Uganda.

Science.gov (United States)

Nanyunja, Miriam; Nabyonga Orem, Juliet; Kato, Frederick; Kaggwa, Mugagga; Katureebe, Charles; Saweka, Joaquim

2011-01-01

Malaria due to P. falciparum is the number one cause of morbidity and mortality in Uganda where it is highly endemic in 95% of the country. The use of efficacious and effective antimalarial medicines is one of the key strategies for malaria control. Until 2000, Chloroquine (CQ) was the first-line drug for treatment of uncomplicated malaria in Uganda. Due to progressive resistance to CQ and to a combination of CQ with Sulfadoxine-Pyrimethamine, Uganda in 2004 adopted the use of ACTs as first-line drug for treating uncomplicated malaria. A review of the drug policy change process and postimplementation reports highlight the importance of managing the policy change process, generating evidence for policy decisions and availability of adequate and predictable funding for effective policy roll-out. These and other lessons learnt can be used to guide countries that are considering anti-malarial drug change in future.

Malaria Treatment Policy Change and Implementation: The Case of Uganda

Directory of Open Access Journals (Sweden)

Miriam Nanyunja

2011-01-01

Full Text Available Malaria due to P. falciparum is the number one cause of morbidity and mortality in Uganda where it is highly endemic in 95% of the country. The use of efficacious and effective antimalarial medicines is one of the key strategies for malaria control. Until 2000, Chloroquine (CQ was the first-line drug for treatment of uncomplicated malaria in Uganda. Due to progressive resistance to CQ and to a combination of CQ with Sulfadoxine-Pyrimethamine, Uganda in 2004 adopted the use of ACTs as first-line drug for treating uncomplicated malaria. A review of the drug policy change process and postimplementation reports highlight the importance of managing the policy change process, generating evidence for policy decisions and availability of adequate and predictable funding for effective policy roll-out. These and other lessons learnt can be used to guide countries that are considering anti-malarial drug change in future.

A guide for controlling consumer products containing radioactive substances

International Nuclear Information System (INIS)

1985-01-01

Consumer products are considered regardless of the purpose for which the radionuclide is added. For example, the purpose may be to make use of the ionising radiation emitted by the substance in the product itself (e.g. radioluminescent devices antistatic devices and ionisation chamber smoke detectors), or to make use of some other property of the material where the presence of radiation in the final product is merely adventitious (e.g. thorium gas mantles, ceramics with uranium glazes, and products containing radioactive tracers added to facilitate manufacturing and inspection processes). The Guide does not cover some products containing natural radioactive substances which have not been intentionally added, such as building materials. The Guide does not cover medicinal products and pharmaceuticals, nuclear powered cardiac pacemakers, or electronic equipment, such as television receivers, that emit X-rays. Unlike the 1970 Guide, this Guide does not consider those products, such as EXIT signs, containing gaseous tritium light sources, that would not be supplied directly to members of the public. The Guide is concerned mainly with the exposure arising from consumer products of those persons who are not subject to any regulatory controls for purposes of radiation protection in normal circumstances. Members of the public come under this heading, but not workers involved in the manufacture of consumer products. These workers will normally be subject to separate control. Radiological protection concepts and policy for the control of radioactive consumer products and licensing and post-licensing surveillance are developed

Does the EU meet its policy objective of 'promoting sustainable use of arctic resources'? An analysis from the viewpoint of arctic energy resources

NARCIS (Netherlands)

Neumann, A.; Hossain, Kamrul

2014-01-01

The EU started to develop its own Arctic policy in 2008. One of the three main objectives of this policy is the promotion of sustainable use of Arctic resources. "Sustainability" was also a focus of the 2011 resolution of the European Parliament as a guiding principle in developing European policies

THE REGULATION OF MONEY CIRCULATION ON THE BASIS OF USING METHODS AND INSTRUMENTS OF MONETARY POLICY

OpenAIRE

S. Mishchenko; S. Naumenkova

2013-01-01

In the article it was researched the instruments and mechanism of safeguarding stability of money market on the basis of implementing the optimal monetary policy regime. It was determined the main directions of appliance the monetary policy methods and instruments to guiding money market stability and it was also investigated the influence of transmission mechanism on providing the soundness of money circulations.

Using research evidence to reframe the policy debate around mental illness and guns: process and recommendations.

Science.gov (United States)

McGinty, Emma E; Frattaroli, Shannon; Appelbaum, Paul S; Bonnie, Richard J; Grilley, Anna; Horwitz, Joshua; Swanson, Jeffrey W; Webster, Daniel W

2014-11-01

Recent mass shootings have prompted a national dialogue around mental illness and gun policy. To advance an evidence-informed policy agenda on this controversial issue, we formed a consortium of national gun violence prevention and mental health experts. The consortium agreed on a guiding principle for future policy recommendations: restricting firearm access on the basis of certain dangerous behaviors is supported by the evidence; restricting access on the basis of mental illness diagnoses is not. We describe the group's process and recommendations.

Conceptualising the policy practice and behavioural research relationship

Directory of Open Access Journals (Sweden)

Yeatman Heather

2008-03-01

Full Text Available Abstract Background Policy is frequently identified in the behavioural nutrition and physical activity research literature as a necessary component of effective research and practice. The purpose of this commentary is to promote a dialogue to contribute towards the further development of conceptual understandings and theories of the relationship between policy practice and behavioural research and how these two activities might work synergistically to improve public health outcomes. Methods Drawing on policy and public health literature, this commentary presents a a conceptual model of the interaction and mediation between nutrition and physical activity-relevant policy and behavioural nutrition and physical activity research, environments, behaviours and public health implications. The selling of food in school canteens in several Australian states is discussed to illustrate components of the relationship and the interactions among its components. Results The model depicts a relationship that is interdependent and cyclic. Policy contributes to the relationship through its role in shaping environmental and personal-cognitive determinants of behaviours and through these determinants it can induce behaviour change. Behavioural research describes behaviours, identifies determinants of behaviour change and therefore helps inform policy development and monitor and evaluate its impact. Conclusion The model has implications for guiding behavioural research and policy practice priorities to promote public health outcomes. In particular, we propose that policy practice and behavioural research activities can be strengthened by applying to each other the theories from the scientific disciplines informing these respective activities. Behavioural science theories can be applied to help understand policy-making and assist with disseminating research into policy and practice. In turn, policy science theories can be applied to support the 'institutionalisation

Co-evolution of soil and water conservation policy and human-environment linkages in the Yellow River Basin since 1949

NARCIS (Netherlands)

Wang, F.; Mu, X.; Li, R.; Fleskens, L.; Stringer, L.C.; Ritsema, C.J.

2015-01-01

Policy plays a very important role in natural resource management as it lays out a government framework for guiding long-term decisions, and evolves in light of the interactions between human and environment. This paper focuses on soil and water conservation (SWC) policy in the Yellow River Basin

ACTORS AND IDEAS OF SOCIAL POLICY IN VENEZUELA (1989-2007

Directory of Open Access Journals (Sweden)

Thais Gutiérrez Briceño

2008-11-01

Full Text Available In this paper we study the ideas that underpin social policy agendas and public social practices implemented in Venezuela during 1989-2007, as well as those actors involved in its design and execution. Two periods are defined: 1989-1998 y 1999-2007, which correspond to overrides in the themes considered. This paper is bibliographic and hemerographic, with emphasis on those relating official discourse on the subject. The conclusion of this paper indicates the presence of substantive changes in the periods mentionated, both in the representations of social policies that guide social actions, and those involved in the process.

The Mossbauer effect in the 40-sec first-excited nuclear level of 109Ag

International Nuclear Information System (INIS)

Razaie-Serej, S.; Hoy, G.R.

1990-01-01

Narrow spectral lines associated with recoilless nuclear gamma-ray transitions (the Mossbauer effect) are prerequisites for the development of gamma-ray lasers. A successful observation of the Mossbauer effect in the 40-sec., first-excited state of 109 Ag will reveal valuable information on the practical limits of such narrow lines. The authors have used the temperature dependence of the self-absorption of 88-keV gamma rays in a 109 Cd-doped silver single crystal to observe the Mossbauer effect. Their results in the horizontal geometry, in agreement with their previous experiments in the vertical geometry, indicate a 0.2% Mossbauer effect at 4.9 K

Cross sections and neutron yields for U-233, U-235 and Pu-239 at 2200 m/sec

Energy Technology Data Exchange (ETDEWEB)

Sjoestrand, N G; Story, J S

1960-04-15

The experimental information on the 2200 m/sec values for {sigma}{sub abs}, {sigma}{sub f}, {alpha}, {nu} and {eta} for {sup 233}U , {sup 235}U and {sup 23} been collected and discussed. The values will later be used in an evaluation of a 'best' set of data. In appendix the isotopic abundances of the uranium isotopes are discussed and also the alpha activities of the uranium isotopes and Pu-239.

Research translation to inform national health policies: learning from multiple perspectives in Uganda

Directory of Open Access Journals (Sweden)

Glass Nancy

2011-03-01

Full Text Available Abstract Background Research and evidence can have an impact on policy and practice, resulting in positive outcomes. However, research translation is a complex, dynamic and non-linear process. Although universities in Africa play a major role in generating research evidence, their strategic approaches to influence health policies and decision making are weak. This study was conducted with the aim of understanding the process of translating research into policy in order to guide the strategic direction of Makerere University College of Health Sciences (MakCHS and similar institutions in their quest to influence health outcomes nationally and globally. Methods A case study approach using 30 in-depth interviews with stakeholders involved in two HIV prevention research project was purposively selected. The study sought to analyze the research-to-policy discourses for the prevention of mother-to-child transmission (PMTCT and safe male circumcision (SMC. The analysis sought to identify entry points, strengths and challenges for research-to-policy processes by interviewing three major groups of stakeholders in Uganda – researchers (8, policy makers (12 and media practitioners (12. Results Among the factors that facilitated PMTCT policy uptake and continued implementation were: shared platforms for learning and decision making among stakeholders, implementation pilots to assess feasibility of intervention, the emerging of agencies to undertake operations research and the high visibility of policy benefits to child survival. In contrast, SMC policy processes were stalled for over two years after the findings of the Uganda study was made public. Among other factors, policy makers demanded additional research to assess implementation feasibility of SMC within ordinary health system context. High level leaders also publicly contested the SMC evidence and the underlying values and messages – a situation that reduced the coalition of policy champions

Collection Development Policy: Federal Government Publications at Eastern Washington University Libraries.

Science.gov (United States)

Roselle, Ann; Chan, Karen

This collection development policy serves as a guide for the selection and retention of depository government documents by the Government Publications Unit of the Kennedy Memorial Library of Eastern Washington University (EWU) in Cheney, Washington. The library selects approximately 65 percent of the depository items distributed by the U.S.…

77 FR 24671 - Compliance Guide for Residue Prevention and Agency Testing Policy for Residues

Science.gov (United States)

2012-04-25

... Hazard Analysis and Critical Control Points (HACCP) inspection system, another important component of the NRP is to provide verification of residue control in HACCP systems. As part of the HACCP regulation... guide, and FSIS finds violative residues, the establishment's HACCP system may be inadequate under 9 CFR...

Donor-assisted Ethno-Nationalism and Education Policy in Bhutan

DEFF Research Database (Denmark)

Schmidt, Johannes Dragsbæk

2017-01-01

, Bhutanization, decentralization and guided democracy. The first part gives an overview of what can be defined as ‘dependency through self-reliance and selection’. The second part deals with the vernaculars of ethnic nationalism as a means to establish Drukpa national and cultural unity as a vehicle......This chapter aims to give an elaborate understanding of the raison d’être of the vertical and horizontal links between the overall planning and policy-making ideology and objectives. This is exemplified with reference to an analysis of education policies and government promotion of GNH...... for modernization and progress. This section also looks at the ideology of Bhutanisation and how it is linked with GNH, decentralization and the introduction of democracy and good governance. The third focuses on the function of education policies and analyzes links and synergies at the level of discursive input...

“In Accordance with Local Conditions”: Policy Design and Implementation of Agrarian Change Policies in Rural China

Directory of Open Access Journals (Sweden)

René Trappel

2016-01-01

Full Text Available An important part of Beijing’s strategy to reduce the welfare gap between urban and rural parts of China has been the promotion of urbanisation. Replacing peasant agriculture with commercial operations of scale is an integral part of this endeavour. This article analyses the implementation of policies meant to transform the structure of Chinese agriculture. It argues that the central government is using a set of very flexible policies, project-based implementation and adaption to local conditions to guide and support an existing dynamic of structural transformation in agriculture. Local governments, in turn, appreciate the flexibility, the political predictability, the potential revenue improvements and the cognitive framework inherent in these programmes. The article is primarily based on interviews with leading cadres at the township and county levels in the provinces of Shandong, Sichuan and Guizhou between 2008 and 2010.

Geothermal Exploration Policy Mechanisms: Lessons for the United States from International Applications

Energy Technology Data Exchange (ETDEWEB)

Speer, Bethany [National Renewable Energy Lab. (NREL), Golden, CO (United States); Economy, Ryan [National Renewable Energy Lab. (NREL), Golden, CO (United States); Lowder, Travis [National Renewable Energy Lab. (NREL), Golden, CO (United States); Schwabe, Paul [National Renewable Energy Lab. (NREL), Golden, CO (United States); Regenthal, Scott [National Renewable Energy Lab. (NREL), Golden, CO (United States)

2014-05-01

This report focuses on five of the policy types that are most relevant to the U.S. market and political context for the exploration and confirmation of conventional hydrothermal (geothermal) resources in the United States: (1) drilling failure insurance, (2) loan guarantees, (3) subsidized loans, (4) capital subsidies, and (5) government-led exploration. It describes each policy type and its application in other countries and regions. It offers policymakers a guide for drafting future geothermal support mechanisms for the exploration-drilling phase of geothermal development.

Translating Government Policy into Recipes for Success! Nutrition Criteria Promoting Fruits and Vegetables

Science.gov (United States)

Pollard, Christina M.; Nicolson, Clemency; Pulker, Claire E.; Binns, Colin W.

2009-01-01

Objective: To develop nutrition criteria consistent with Australian dietary guidelines encouraging fruit and vegetable consumption for branding recipes with the "Go for 2&5" campaign message. Design: Dietary policies, guidelines, food selection guides, nutrient targets, existing consumer education programs' nutrition criteria, food…

A study of polymerization of aspen (Populus) wood lipophilic extractives by SEC and Py-GC/MS

CSIR Research Space (South Africa)

Sithole, Bruce

2013-03-01

Full Text Available ) Orig inal manuscript received 13 June 2012, revision accepted 31 October 2012 Vol 66 No 1 January - March 2013 1 PEER REVIEWED A study of polymerization of aspen (Populus) wood lipophilic extractives by SEC and Py-GC/MS BRUCE SITHOLE1*, LUC... of polymerized wood resin that will be difficult to remove if present in pulp and paper products. On the other hand, these problems may be minor compared to using unseasoned wood. KEYWORDS: Aspen, extractives, polymerization, size exclusion chromatography, Py...

Dayton Aircraft Cabin Fire Model, Version 3. Volume II. Program User’s Guide and Appendices.

Science.gov (United States)

1982-06-01

HEAT RELEASE RATE (BTU/FT*FT*SEC) FOR A FIRE C FLML - FLAME LENGTH OF A FIRE. SUBSCR IS FIRE NUMBER (FT) C FSN1 - COUNTER OF NUMBER OF FLAMING...53H ENTRMNT FLAME LENGTH ABSN COEFF SMOKE GEN RATE 0 2 *14HXY CNSPTN RATE/ 3 9X,53H(SG FT) (CU FT/SEC) (BTU/SEC) (CU FT/SEC) 4 .53H (FT) (l/FT) (PART...THE CENTER OF THE FIRE BASE FROM THE C FLOOR C C YZ - THE HYDRAULIC RADIUS OF THE FIRE BASE AREA C C FLML - THE FLAME LENGTH FOR THE FIRE C C ALPC

SEE Action Guide for States: Energy Efficiency as a Least-Cost Strategy to Reduce Greenhouse Gases and Air Pollution and Meet Energy Needs in the Power Sector

Energy Technology Data Exchange (ETDEWEB)

Schwartz, Lisa [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Leventis, Greg [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Schiller, Steven R. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Fadrhonc, Emily Martin [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); shenot, John [US Department of Energy, Washington, DC (United States); Colburn, Ken [US Department of Energy, Washington, DC (United States); James, Chris [US Department of Energy, Washington, DC (United States); Zetterberg, Johanna [US Department of Energy, Washington, DC (United States); Roy, Molly [US Department of Energy, Washington, DC (United States)

2016-02-01

This guide is designed to provide information to state decision makers and staff on options to advance energy efficiency through strategies designed or implemented at the state and local levels of government and in the private sector.1 The information in this guide is intended to be useful to a wide variety of partners and stakeholders involved in energy-related discussions and decision-making at state and local levels. These energy efficiency options, or “pathways” as they are identified in this guide, can assist states in using energy efficiency to meet air pollution reduction and other policy objectives such as energy affordability and reliability. A pathway is a set of interdependent actions that results in measurable energy savings streams and associated avoided air emissions and other benefits over a period of time. These activities can include state, local, or private sector regulations, policies, programs and other activities. For each of five broad pathways that offer sizable cost-effective energy savings, the guide addresses likely questions policy makers and regulators face when screening for the best opportunities to advance energy efficiency in their state.

The global agenda council on the ageing society: policy principles

DEFF Research Database (Denmark)

Olshansky, S. Jay; Biggs, Simon; Achenbaum, W. Andrew

2011-01-01

In 2008, the World Economic Forum (WEF) created the Global Agenda Councils – an amalgamation of scientists, public policy makers, academics, physicians and business leaders with the task of devising transformational innovation in global governance for the purpose of advancing knowledge and collab......In 2008, the World Economic Forum (WEF) created the Global Agenda Councils – an amalgamation of scientists, public policy makers, academics, physicians and business leaders with the task of devising transformational innovation in global governance for the purpose of advancing knowledge......, proposing solutions, devising strategies, making public policy proposals and evaluating the effectiveness of actions using measurable benchmarks. This report is the first product of the WEF’s Council on the Ageing Society – our goal is to lay down the initial principles that will guide our actions...

Guide to Effective Business Practices in Buying School Supplies, Instructional Materials, Equipment and Services.

Science.gov (United States)

Association of School Business Officials International, Reston, VA.

This guide to effective business practices is intended to assist schools in establishing general policies and procedures for buying supplies, instructional materials, equipment, and services. Federal, state, and local laws must be considered in addition to the recommendations made in this report. Practical guidelines are given for selecting…

THE REGULATION OF MONEY CIRCULATION ON THE BASIS OF USING METHODS AND INSTRUMENTS OF MONETARY POLICY

Directory of Open Access Journals (Sweden)

S. Mishchenko

2013-05-01

Full Text Available In the article it was researched the instruments and mechanism of safeguarding stability of money market on the basis of implementing the optimal monetary policy regime. It was determined the main directions of appliance the monetary policy methods and instruments to guiding money market stability and it was also investigated the influence of transmission mechanism on providing the soundness of money circulations.

Keeping it wild in the National Park Service: A user guide to integrating wilderness character into park planning, management, and monitoring

Science.gov (United States)

Peter Landres; Suzy Stutzman; Wade Vagias; Carol Cook; Christina Mills; Tim Devine; Sandee Dingman; Adrienne Lindholm; Miki Stuebe; Melissa Memory; Ruth Scott; Michael Bilecki; Ray O' Neil; Chris Holbeck; Frank Turina; Michael Haynie; Sarah Craighead; Chip Jenkins; Jeremy Curtis; Karen Trevino

2014-01-01

This User Guide was developed to help National Park Service (NPS) staff effectively and efficiently fulfill the mandate from the 1964 Wilderness Act and NPS policy to "preserve wilderness character" now and into the future. This mandate applies to all congressionally designated wilderness and other park lands that are, by policy, managed as wilderness,...

[Health technology assessment and its impact on pharmaceutical pricing and reimbursement policies].

Science.gov (United States)

Castillo-Laborde, Carla; Silva-Illanes, Nicolás

2014-01-01

The article conceptualizes the pharmaceutical pricing and reimbursement policies related to financial coverage in the context of health systems. It introduces the pharmaceutical market as an imperfect one, in which appropriate regulation is required. Moreover, the basis that guide the pricing and reimbursement processes are defined and described in order to generate a categorization based on whether they are intended to assess the 'added value' and if the evaluation is based on cost-effectiveness criteria. This framework is used to review different types of these policies applied in the international context, discussing the role of the Health Technology Assessment in these processes. Finally, it briefly discusses the potential role of these types of policies in the Chilean context.

Translanguaging in Self-Access Language Advising: Informing Language Policy

Directory of Open Access Journals (Sweden)

Naoki Fujimoto-Adamson

2012-03-01

Full Text Available This study investigates language advising in a self-access center (SAC with the purpose of informing language policy. This center is located in a new Japanese university and has shifted from an initially teacher-imposed ‘English-only’ language policy into one which encourages “translanguaging” (Blackledge & Creese, 2010, p. 105 between the students’ and center advisors’ (termed as mentors in this center L1 (Japanese and their L2 (English. Data from audio-recordings of interaction with advisors and students and between students themselves, interviews with mentors, and student questionnaires all reveal how translanguaging occurs in practice and how it helps to create a learning space in which the “local, pragmatic coping tactics” (Lin, 2005, p. 46 of code-switching offer a more viable approach for learning than under its initial monolingual policy. Mentor interviews and student questionnaires indicate generally positive attitudes towards translanguaging; however, some students still favor an ‘English-only’ policy. Conclusions reveal that a looser language policy in the center is emerging in which mentors now guide students towards their own individualized language policies. It is argued in this paper that this “code choice” (Levine, 2011 in language use is therefore aligned more closely to the principles of student-direction in self-access use.

Energy policy of France; Politique energetique de la France

Energy Technology Data Exchange (ETDEWEB)

Revol, H

2001-07-01

In November 1997, the French senate decided the creation of an inquiry commission in order to start up a study about the future of the French energy policy. The commission has interviewed the overall actors of the energy policy: ministers, heads of energy companies, higher officials, syndicates, consumer and environment protection associations, scientists and economists. The inquiry has been extended to other countries of the European community, and also to China, Japan, the USA and Canada. Despite various economical contexts and resources, all these countries have developed energy policies which aim at ensuring an energy independence and at supplying energy at the best price for a better economic competitiveness. This report presents first the French experience and the evolution of the French energy policy during the last 50 years with respect to the economical and political constraints encountered. The second part is a reflection about the principles that will guide the French energy policy in the context of deregulation of the European energy market and of the environmental constraints imposed by the Kyoto summit. Detailed proposals for the increase of the French energy independence are presented in conclusion of the report. (J.S.)

Diffusion of Complete Streets policies Across US communities.

Science.gov (United States)

Moreland-Russell, Sarah; Eyler, Amy; Barbero, Colleen; Hipp, J Aaron; Walsh, Heidi

2013-01-01

Complete Streets policies guide planning in communities by making the transportation system accommodating to all users including vehicle drivers, pedestrians, and bicyclists, as well as those using public transportation. While the number of Complete Streets policies has increased over the past decade, no research has explored the factors attributing to the widespread diffusion of these policies. The purpose of this study was to apply concepts of the Diffusion of Innovation Theory to data related to Complete Streets policies in order to identify potential patterns and correlates. The main outcome of this study was policy adoption. Using the Diffusion of Innovation Theory and results from previous literature, we identified several factors that had the potential to affect the rate of Complete Streets policy diffusion: rural/urban status, state obesity rate, state funding for transportation, state obesity prevention funding, percentage of people who walk or bike to work in the state, presence of a state Complete Streets policy, and the number of bordering communities with Complete Streets policy. We used event history analysis as the main analysis method. Data from 49 community-level policies were analyzed, with a "community" defined as a city, a county, or a regional/Metropolitan Planning Organization. Three variables were significant predictors of Complete Streets policy adoption: state obesity rate (odds ratio [OR] = 1.465; confidence interval [CI] = 1.10-1.96) percentage of people who bike or walk to work in the state (OR = 1.726; CI = 1.069-2.79), and presence of a border community with a Complete Streets policy (OR = 3.859; CI = 1.084-13.742). Communities with Complete Streets policies varied in geographic and sociodemographic factors. Information about communities that are more likely to adopt a policy can be a tool for advocates and policy makers interested in this topic. Because adoption does not imply implementation, further research is needed to study

School Health Index: A Self-Assessment and Planning Guide. Middle School/High School.

Science.gov (United States)

Barrios, Lisa C.; Burgeson, Charlene R.; Crossett, Linda; Harrykissoon, Samantha D.; Pritzl, Jane; Wechsler, Howell; Kuester, Sarah A.; Pederson, Linda; Graffunder, Corinne; Rainford, Neil; Sleet, David

2004-01-01

The "School Health Index" is a self-assessment and planning guide that will enable schools to: (1) identify the strengths and weaknesses of school policies and programs for promoting health and safety; (2) develop an action plan for improving student health and safety, and (3) involve teachers, parents, students, and the community in improving…

Chinese Foreign Policy in a Global Perspective: A Responsible Reformer "Striving For Achievement"

Directory of Open Access Journals (Sweden)

Mikael Weissmann

2015-12-01

Full Text Available During the last four decades, China has moved from being an isolated country separated from the international community to having become one of the world’s major powers. It is vital to understand what is guiding Chinese foreign policy, why this is so, and not least what kind of power China is and will be in the future. This article analyses the vital elements and thinking that guides Chinese foreign policy, its priorities and decision making process. It is found that China's foreign policy is embedded in domestic issues. The foremost foreign policy objective is domestic political stability, which in turn is a necessity for the survival of one-party rule. Both are dependent on a combination of two key factors: continuing domestic economic growth and nationalism. The foreign policy is also closely linked to the Chinese self-perception, both its self-superiority/self-inferiority dualism and its multitude of confusing (overlapping identities about what China is and should be. A key turning year is 2008 when the "global" financial crisis severely affected the United States and Europe at a time of Chinese economic success, which gave China confidence to pursue a more active and aggressive/assertive stance on the international stage. It is concluded that China under Xi Jinping will not be a status que power accepting the world as it is, but nor are we to expect China to become a revisionist power aiming to remodel the global order. China is what can best be described as a responsible reformer "striving for achievements".

Nurses' engagement in AIDS policy development.

Science.gov (United States)

Richter, M S; Mill, J; Muller, C E; Kahwa, E; Etowa, J; Dawkins, P; Hepburn, C

2013-03-01

A multidisciplinary team of 20 researchers and research users from six countries - Canada, Jamaica, Barbados, Kenya, Uganda and South Africa - are collaborating on a 5-year (2007-12) program of research and capacity building project. This program of research situates nurses as leaders in building capacity and promotes collaborative action with other health professionals and decision-makers to improve health systems for human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS) nursing care. One of the projects within this program of research focused on the influence of workplace policies on nursing care for individuals and families living with HIV. Nurses are at the forefront of HIV prevention and AIDS care in these countries but have limited involvement in related policy decisions and development. In this paper, we present findings related to the barriers and facilitators for nurses' engagement in policymaking. A participatory action research design guided the program of research. Purposive sampling was used to recruit 51 nurses (unit managers, clinic and healthcare managers, and senior nurse officers) for interviews. Participants expressed the urgent need to develop policies related to AIDS care. The need to raise awareness and to 'protect' not only the workers but also the patients were critical reason to develop policies. Nurses in all of the participating countries commented on their lack of involvement in policy development. Lack of communication from the top down and lack of information sharing were mentioned as barriers to participation in policy development. Resources were often not available to implement the policy requirement. Strong support from the management team is necessary to facilitate nurses involvement in policy development. The findings of this study clearly express the need for nurses and all other stakeholders to mobilize nurses' involvement in policy development. Long-term and sustained actions are needed to address

Evaluating Alcohol Control Policies in Peru and St. Kitts and Nevis ...

International Development Research Centre (IDRC) Digital Library (Canada)

Alcohol is the world's third largest risk factor for disease burden. It has had a dramatic impact on morbidity, mortality, and healthcare costs in South America and the Caribbean. This project aims to inform policymakers in two countries with emerging alcohol policies: Peru and St. Kitts and Nevis. It is designed to help guide ...

The Impact of College Drug Policy on Students' Drug Usage

Science.gov (United States)

Sawyer, Holly N.

2012-01-01

Illicit drug usage at Historically Black Colleges and Universities (HBCU) is a topic of limited research. The research questions that guided this study were (a) What is the relationship between college policy on illicit drugs and students' frequency of drug usage after controlling for college location (urban or rural) and students' age,…

A national public health programme on gambling policy development in New Zealand: insights from a process evaluation.

Science.gov (United States)

Kolandai-Matchett, Komathi; Landon, Jason; Bellringer, Maria; Abbott, Max

2018-03-06

In New Zealand, a public health programme on gambling policy development is part of a national gambling harm reduction and prevention strategy mandated by the Gambling Act 2003. Funded by the Ministry of Health, the programme directs workplace/organisational gambling policies, non-gambling fundraising policies, and local council policies on electronic gaming machines (EGMs). We carried out a process evaluation of this programme to identify practical information (e.g. advocacy approaches; challenges and ameliorating strategies) that can be used by programme planners and implementers to reinforce programme effectiveness and serve to guide similar policy-focused public health initiatives elsewhere. Evaluation criteria, based on the programme's official service specifications, guided our evaluation questions, analysis and reporting. To identify informative aspects of programme delivery, we thematically analysed over 100 six-monthly implementer progress reports (representing 3 years of programme delivery) and transcript of a focus group with public health staff. Identified output-related themes included purposeful awareness raising to build understanding about gambling harms and the need for harm-reduction policies and stakeholder relationship development. Outcome-related themes included enhanced community awareness about gambling harms, community involvement in policy development, some workplace/organisational policy development, and some influences on council EGM policies. Non-gambling fundraising policy development was not common. The programme offers an unprecedented gambling harm reduction approach. Although complex (due to its three distinct policy focus areas targeting different sectors) and challenging (due to the extensive time and resources needed to develop relationships and overcome counteractive views), the programme resulted in some policy development. Encouraging workplace/organisational policy development requires increased awareness of costs to

Heterozygous Loss-of-Function SEC61A1 Mutations Cause Autosomal-Dominant Tubulo-Interstitial and Glomerulocystic Kidney Disease with Anemia

Czech Academy of Sciences Publication Activity Database

Bolar, N. A.; Golzio, C.; Živná, M.; Hayot, G.; Van Hemelrijk, C.; Schepers, D.; Vandeweyer, G.; Hoischen, A.; Huyghe, J. R.; Raes, A.; Matthys, E.; Sys, E.; Azou, M.; Gubler, M. C.; Praet, M.; Van Camp, G.; McFadden, K.; Pediaditakis, I.; Přistoupilová, A.; Hodaňová, K.; Vyleťal, P.; Hartmannová, H.; Stránecký, V.; Hůlková, H.; Barešová, V.; Jedličková, I.; Sovová, J.; Hnízda, Aleš; Kidd, K.; Bleyer, A. J.; Spong, R. S.; Vande Walle, J.; Mortier, G.; Brunner, H.; Van Laer, L.; Kmoch, S.; Katsanis, N.; Loeys, B. L.

2016-01-01

Roč. 99, č. 1 (2016), s. 174-187 ISSN 0002-9297 R&D Projects: GA MŠk(CZ) LO1304 Institutional support: RVO:61388963 Keywords : Sec61 * tubulo-interstitial kidney disease * rare disease Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 9.025, year: 2016 http://www.sciencedirect.com/science/article/pii/S0002929716301999

The tariff policy in Romania - strategic elements for developing electricity supply

International Nuclear Information System (INIS)

Manea, D.; Indre, G.; Gugu, F.; Vilceanu, M.

1995-01-01

This paper presents the guiding lines of the Romanian policy for electricity rates and tariffs. The main constraints and difficulties of the electricity rates and tariffs designing activity in a transitional economy are analysed, focusing on: financial and economic aspects, such as the dramatic decrease of economic activity, high inflation, scarcity of financial resources...; technical aspects related to the existing metering equipment and obsolete electricity generation, transmission and distribution facilities; social aspects regarding the impact of using energy tariffs designed taking into account the real costs of the electricity company; regulatory policy, legal and administrative aspects

Merging Energy Policy Decision Support, Education, and Communication: The 'World Energy' Simulation Role-Playing Game

Science.gov (United States)

Rooney-varga, J. N.; Franck, T.; Jones, A.; Sterman, J.; Sawin, E.

2013-12-01

To meet international goals for climate change mitigation and adaptation, as well as energy access and equity, there is an urgent need to explore and define energy policy paths forward. Despite this need, students, citizens, and decision-makers often hold deeply flawed mental models of the energy and climate systems. Here we describe a simulation role-playing game, World Energy, that provides an immersive learning experience in which participants can create their own path forward for global energy policy and learn about the impact of their policy choices on carbon dioxide emissions, temperature rise, energy supply mix, energy prices, and energy demand. The game puts players in the decision-making roles of advisors to the United Nations Sustainable Energy for All Initiative (drawn from international leaders from industry, governments, intergovernmental organizations, and citizens groups) and, using a state-of-the-art decision-support simulator, asks them to negotiate a plan for global energy policy. We use the En-ROADS (Energy Rapid Overview and Decision Support) simulator, which runs on a laptop computer in <0.1 sec. En-ROADS enables users to specify many factors, including R&D-driven cost reductions in fossil fuel-based, renewable, or carbon-neutral energy technologies; taxes and subsidies for different energy sources; performance standards and energy efficiency; emissions prices; policies to address other greenhouse gas emissions (e.g., methane, nitrous oxide, chlorofluorocarbons, etc.); and assumptions about GDP and population. In World Energy, participants must balance climate change mitigation goals with equity, prices and access to energy, and the political feasibility of policies. Initial results indicate participants gain insights into the dynamics of the energy and climate systems and greater understanding of the potential impacts policies.

ALS beamline design requirements: A guide for beamline designers

Energy Technology Data Exchange (ETDEWEB)

NONE

1996-06-01

This manual is written as a guide for researchers in designing beamlines and endstations acceptable for use at the ALS. It contains guidelines and policies related to personnel safety and equipment and vacuum protection. All equipment and procedures must ultimately satisfy the safety requirements set aside in the Lawrence Berkeley National Laboratory (LBNL) Health and Safety Manual (PUB-3000) which is available from the ALS User Office or on the World WideWeb from the LBNL Homepage (http:// www.lbl.gov).

An interagency space nuclear propulsion safety policy for SEI - Issues and discussion

Science.gov (United States)

Marshall, A. C.; Sawyer, J. C., Jr.

1991-01-01

An interagency Nuclear Safety Policy Working Group (NSPWG) was chartered to recommend nuclear safety policy, requirements, and guidelines for the Space Exploration Initiative nuclear propulsion program to facilitate the implementation of mission planning and conceptual design studies. The NSPWG developed a top level policy to provide the guiding principles for the development and implementation of the nuclear propulsion safety program and the development of Safety Functional Requirements. In addition, the NSPWG reviewed safety issues for nuclear propulsion and recommended top level safety requirements and guidelines to address these issues. Safety topics include reactor start-up, inadvertent criticality, radiological release and exposure, disposal, entry, safeguards, risk/reliability, operational safety, ground testing, and other considerations. In this paper the emphasis is placed on the safety policy and the issues and considerations that are addressed by the NSPWG recommendations.

POLICY FRAMEWORK FOR UTILIZATION AND CONSERVATION OF BELOW-GROUND BIODIVERSITY IN KENYA

Directory of Open Access Journals (Sweden)

Celline Achieng

2009-10-01

Full Text Available The reasons for the lack of inclusion of below-ground biodiversity in the Kenyan policy and legal framework were sought. Gaps were identified in the relevant sectoral policies and laws in regard to the domestication of the Convention on Biological Diversity (CBD. Below -ground biodiversity had no specific schedule in any of the sectoral laws. Most sectoral laws were particular about the larger biodiversity and soils but had no mention of below-ground biodiversity. Material Transfer Agreements and Material Acquisition Agreements that are regarded as tools of domestication of the CBD to guide transfers, exchanges and acquisition of soil organisms lacked a regulating policy. The lack of regulating policy could be attributed to the delay in approval of draft regulations by the Ministry of Environment while the lack of inclusion of below-ground biodiversity in Kenya’s legal and policy framework could be as a result of lack of awareness and appreciation among stakeholders.

Neutron spectrum measurements from a neutron guide tube facility at the ETRR-1 reactor

Energy Technology Data Exchange (ETDEWEB)

Maayouf, R M.A.; El-Sayed, L A.A.; El-Kady, A S.I. [Reactor and Neutron Physics Dept., NRC, Atomic Energy Authority, Cairo (Egypt)

1997-12-31

The present work deals with measurements of the neutron spectrum emitted from a neutron guide tube (NGT) recently installed at one of the ETRR-1 reactor horizontal channels designed to deliver thermal neutrons, free from fast neutrons and gamma ray background, to a fourier reverse-time-of-flight (RTOF) diffractometer. The measurements were performed using a {sup 6} Li glass scintillation detector combined with a multichannel analyzer set at channel width 4 M sec and installed at 3.4 m from a disc Fermi chopper. Also a theoretical model was specially developed for the neutron spectrum calculations. According to the model developed, the spectrum calculated was found to be in good agreement with the measured one. It was found, both from measurements and calculations, that the spectrum emitted from the NGT covers, after transmission through a fourier chopper, neutron wavelengths from 1-4 A adequate for neutron diffraction measurements at D values between 0.71-2.9 A respectively. 6 FIGS.

BUGS at work : a bicycle user group guide

Energy Technology Data Exchange (ETDEWEB)

NONE

2002-07-01

This guide provides practical advice to cyclists on how start a Bicycle User Group (BUG) at their workplace. It offers tools to encourage employers to be proactive in improving facilities in support of cycle commuting. Several BUGs across Canada have worked towards getting better bicycle parking, lockers and shower facilities at their workplace. Other incentives include policies such as flexible work hours for cyclist commuters; casual dress on Friday; reimbursement for the subsidized cost of free parking provided by employers; and, use of a company car if needed for company business during the work day. The advantages to employers include: reduced health care costs because cyclists are physically fit; decreased absenteeism; increased productivity; reduced parking costs; lower company transportation bills; and, a greener corporate image. BUGs provide cycling information ranging from cycling maps to pamphlets and they raise cycle awareness. This guide includes cycling survey samples and examples of successful BUG activities across Canada. refs., tabs., figs.

Implementation of Ecological Policies in Danube Delta Area

Directory of Open Access Journals (Sweden)

Trifon Belacurencu

2007-04-01

Full Text Available Public authorities and the local community have become lately increasingly aware of the complex relationship between the environment and the economic activity and of the need for integrating environmental requirements into economic activities. Therefore, a strategy that aims at a sustained development which takes into account the environmental aspects is imperative. Environmental policies represent a set of measures and tools with the objective of controlling and limiting the process of deterioration of environment quality. The design of environmental policies for the Danube Delta is not an easy task, due primarily to the major changes that affect the deltaic ecosystem, the patterns of behavior and consumption, poverty and isolation of the local communities, etc. The environmental policies in the Danube Delta have no longer an auxiliary role, rather reactive, but instead they are meant to set objectives at the economic, legal, educational and social levels and to guide the strategy for their achievement. In this paper I have outlined both the objectives of the environmental policies and the types of measures (general, direct and indirect for their implementation in the area of the Danube Delta.

Six policy actions for accelerated deployment of renewable energy. READy Renewable Energy Action on Deployment. Summary

Energy Technology Data Exchange (ETDEWEB)

NONE

2012-03-15

The READy book presents a kaleidoscope of policy options that have proven to accelerate the deployment of renewable energy technologies, based on experiences around the world at the local and national levels. Lessons learned from successful cases are distilled into six essential action points. Together these categories of policy actions compose the ACTION Star, a guide for taking action now while preparing for growth over the long term.

National policies for the promotion of physical activity and healthy nutrition in the workplace context: a behaviour change wheel guided content analysis of policy papers in Finland.

Science.gov (United States)

Seppälä, Tuija; Hankonen, Nelli; Korkiakangas, Eveliina; Ruusuvuori, Johanna; Laitinen, Jaana

2017-08-02

Health policy papers disseminate recommendations and guidelines for the development and implementation of health promotion interventions. Such documents have rarely been investigated with regard to their assumed mechanisms of action for changing behaviour. The Theoretical Domains Framework (TDF) and Behaviour Change Techniques (BCT) Taxonomy have been used to code behaviour change intervention descriptions, but to our knowledge such "retrofitting" of policy papers has not previously been reported. This study aims first to identify targets, mediators, and change strategies for physical activity (PA) and nutrition behaviour change in Finnish policy papers on workplace health promotion, and second to assess the suitability of the Behaviour Change Wheel (BCW) approach for this purpose. We searched all national-level health policy papers effectual in Finland in August 2016 focusing on the promotion of PA and/or healthy nutrition in the workplace context (n = 6). Policy recommendations targeting employees' nutrition and PA including sedentary behaviour (SB) were coded using BCW, TDF, and BCT Taxonomy. A total of 125 recommendations were coded in the six policy papers, and in two additional documents referenced by them. Psychological capability, physical opportunity, and social opportunity were frequently identified (22%, 31%, and 24%, respectively), whereas physical capability was almost completely absent (1%). Three TDF domains (knowledge, skills, and social influence) were observed in all papers. Multiple intervention functions and BCTs were identified in all papers but several recommendations were too vague to be coded reliably. Influencing individuals (46%) and changing the physical environment (44%) were recommended more frequently than influencing the social environment (10%). The BCW approach appeared to be useful for analysing the content of health policy papers. Paying more attention to underlying assumptions regarding behavioural change processes may help to

Computational Aerodynamic Simulations of a 1215 ft/sec Tip Speed Transonic Fan System Model for Acoustic Methods Assessment and Development

Science.gov (United States)

Tweedt, Daniel L.

2014-01-01

Computational Aerodynamic simulations of a 1215 ft/sec tip speed transonic fan system were performed at five different operating points on the fan operating line, in order to provide detailed internal flow field information for use with fan acoustic prediction methods presently being developed, assessed and validated. The fan system is a sub-scale, low-noise research fan/nacelle model that has undergone extensive experimental testing in the 9- by 15-foot Low Speed Wind Tunnel at the NASA Glenn Research Center. Details of the fan geometry, the computational fluid dynamics methods, the computational grids, and various computational parameters relevant to the numerical simulations are discussed. Flow field results for three of the five operating points simulated are presented in order to provide a representative look at the computed solutions. Each of the five fan aerodynamic simulations involved the entire fan system, which for this model did not include a split flow path with core and bypass ducts. As a result, it was only necessary to adjust fan rotational speed in order to set the fan operating point, leading to operating points that lie on a fan operating line and making mass flow rate a fully dependent parameter. The resulting mass flow rates are in good agreement with measurement values. Computed blade row flow fields at all fan operating points are, in general, aerodynamically healthy. Rotor blade and fan exit guide vane flow characteristics are good, including incidence and deviation angles, chordwise static pressure distributions, blade surface boundary layers, secondary flow structures, and blade wakes. Examination of the flow fields at all operating conditions reveals no excessive boundary layer separations or related secondary-flow problems.

Sec. 46 of the radiation protection ordinance - waiting for implementing regulations

International Nuclear Information System (INIS)

Maushart, R.

1977-01-01

There is much uncertainty among the users of radioactive substances in research and medicine about the practical consequences stemming from Sec. 46 of the new Radiation Protection Ordinance with respect to releases of radionuclides with the air and water. On the one hand, the 30 mrem concept has drastically curbed permissible release concentrations. In addition, balancing for each specific nuclide has become compulsory. Both conditions would demand a revision and extension of present measuring techniques. However, the responsible supervisory authorities are unable to issue any rules or regulations as long as there are no uniform standards. The consequence is a complete lack of knowledge, both on the part of users and the supplying industries, about the future expenditure necessary for liquid and gaseous effluent control and the technical performance criteria to be met by radiation measuring equipment. It is to be hoped that these implementing regulations, which are so urgently needed, will soon be published so as to allow users to engage in meaningful and binding planning again, both technically and financially. (orig.) [de

Development of a National Aboriginal and Torres Strait Islander Cancer Framework: A Shared Process to Guide Effective Policy and Practice

Directory of Open Access Journals (Sweden)

Jenny Brands

2018-05-01

Full Text Available Indigenous Australians experience a substantially higher cancer mortality rate than non-Indigenous Australians. While cancer outcomes are improving for non-Indigenous Australians, they are worsening for Indigenous Australians. Reducing this disparity requires evidence-based and culturally-appropriate guidance. The purpose of this paper is to describe an initiative by Cancer Australia and Menzies School of Health Research (Menzies to develop Australia’s first National Aboriginal and Torres Strait Islander Cancer Framework using a process of co-design with relevant stakeholders. The initiative was guided by three core principles: achieving policy-relevant evidence-based outcomes; engaging and maintaining trust with Indigenous Australians at every phase; and employing best-practice and appropriate research methods. Four components of research comprised the Framework development: evidence review; multifaceted stakeholder consultation and input; triangulation of findings; and direct stakeholder input in drafting and refining the Framework. The evidence review confirmed the increasing burden of cancer on Indigenous Australians, while stakeholder consultations facilitated comprehensive input from those with lived experience. The consultations revealed issues not identified in existing literature, and gave different emphases of priority, thus reinforcing the value of including stakeholder perspectives. This paper focuses primarily on documenting the methods used; findings are presented only in order to illustrate the results of the process. The published Framework is available at www.canceraustralia.gov.au; further description and analyses of findings from the consultations will be published elsewhere. The logistics inherent in large-scale consultation are considerable. However, the quality of data and the foundation for sustained partnership with stakeholders and knowledge translation vastly outweighed the challenges. The process of wide

Climate change policy position

International Nuclear Information System (INIS)

2002-11-01

The Canadian Association of Petroleum Producers (CAPP) is a firm believer in the need to take action to mitigate the risks associated with climate change, and that clear government policy is called for. The principles of sustainable development must guide this policy development effort. The initiatives required to address greenhouse gas emissions over both the short and long term must be carefully considered, and it is up to industries to ensure their production efficiency and emission intensity. Promoting improved performance of industries in Canada and developing technology that can be deployed internationally for larger global effects represents Canada's best contribution to progress on greenhouse gas emissions. The increase in energy demand along with increases in population and economic growth have contributed to an increase in greenhouse gas emissions despite improved energy efficiency in industry. Significant damage to the economy will result if Canada is to meet its commitment under the Kyoto Protocol, forcing the country to buy large quantities of foreign credits instead of using those funds for increased research and development. CAPP indicated that an effective plan must be: balanced, equitable, responsible, competitive, focused on technology and innovation, and based on agreements on sectoral plans. Each of these principles were discussed, followed by the fundamentals of approach for upstream oil and gas. The framework for climate change policy was described as well as the elements of a sector plan. CAPP wants to work with all levels of government on an appropriate plan for Canada, that considers our unique circumstances. Canada can play a significant role on the international stage by properly implementing the policy position proposed by the CAPP without unnecessary risks to the economy. refs

Beyond the Paycheck: A Human Resources Management Guide for Leaders of Small Youth-Serving Organizations

Science.gov (United States)

Casey, Thomas P.

2009-01-01

This guide aims to help organization leaders develop the tools and knowledge they need to create and use sound human resources management (HRM) systems and practices that support program success and sustainability. It identifies key components of HRM systems and discusses important considerations in designing HRM policies, procedures, and…

A qualitative examination of psychology graduate students' experiences with guided Internet-delivered cognitive behaviour therapy

Directory of Open Access Journals (Sweden)

Lindsay N. Friesen

2014-04-01

Full Text Available Guided Internet-delivered cognitive behaviour therapy (ICBT is efficacious for the treatment of a variety of clinical disorders (Spek et al., 2007, yet minimal research has investigated training students in guided ICBT. To contribute to the training literature, through qualitative interviews, this study explored how ICBT was perceived by student therapists (n = 12 trained in guided ICBT. Additionally, facilitators and challenges encountered by students learning guided ICBT were examined. Qualitative analysis revealed that students perceived training to enhance their professional skills in guided ICBT such as how to gain informed consent, address emergencies, and facilitate communication over the Internet. Students described guided ICBT as beneficial for novice therapists learning cognitive behavior therapy as asynchronous communication allowed them to reflect on their clinical emails and seek supervision. Further, students perceived guided ICBT as an important skill for future practice and an avenue to improve patient access to mental health care. Specific facilitators of learning guided ICBT included having access to formal and peer supervision as well as technical assistance, ICBT modules, a functional web application, and detailed policies and procedures for the practice of guided ICBT. Challenges in delivering guided ICBT were also identified by participants such as finding time to learn the approach given other academic commitments, working with non-responsive clients, addressing multiple complex topics over email, and communicating through asynchronous emails. Based on the feedback collected from participants, recommendations for training in guided ICBT are offered along with future research directions.

Towards triple-A policies. More renewable energy at lower cost. D16 Report

Energy Technology Data Exchange (ETDEWEB)

Rathmann, M.; De Jager, D.; De Lovinfosse, I. [Ecofys, Utrecht (Netherlands); Breitschopf, B. [Fraunhofer Institute for Systems and Innovation Research ISI, Karlsruhe (Germany); Burgers, J. [KEMA, Arnhem (Netherlands); Weoeres, B. [EnergoBanking, Budapest (Hungary)

2011-11-15

The core objective of the RE-Shaping project is to assist Member State governments in preparing for the implementation of Directive 2009/28/EC (on the promotion of the use of energy from renewable sources) and to guide a European policy for RES (renewable energy sources) in the mid- to long term. The past and present success of policies for renewable energies will be evaluated and recommendations derived to improve future RES support schemes. The core content of this collaborative research activity comprises: Developing a comprehensive policy background for RES support instruments; Providing the European Commission and Member States with scientifically based and statistically robust indicators to measure the success of currently implemented RES policies; Proposing innovative financing schemes for lower costs and better capital availability in RES financing; Initiation of National Policy Processes which attempt to stimulate debate and offer key stakeholders a meeting place to set and implement RES targets as well as options to improve the national policies fostering RES market penetration; Assessing options to coordinate or even gradually harmonize national RES policy approaches.

Metabolism of the insecticidally active GABA sub A receptor antagonist 4-sec-(3,4- sup 3 H sub 2 )butyl-1-(4-cyanophenyl)-2,6,7-trioxabicyclo(2. 2. 2)octane

Energy Technology Data Exchange (ETDEWEB)

Deng, Yanli; Palmer, C.J.; Toia, R.F.; Casida, J.E. (Univ. of California, Berkeley (USA))

1990-03-01

4-sec-(3,4-{sup 3}H{sub 2})Butyl-1-(4-cyanophenyl)-2,6,7-trioxabicyclo(2.2.2)octane (referred to as ({sup 3}H)COB) was examined as an example of a new class of insecticidally active compounds that block the {gamma}-aminobutyric acid gated chloride channel. Metabolites were identified by thin-layer cochromatography with standards from synthesis and by consideration of their hydrolytic and oxidative degradation products formed in situ on two-dimensional silica gel chromatoplates. Metabolism of ({sup 3}H)COB by mouse liver and housefly abdomen microsomes is dependent on fortification with NADPH. The O-methylene and sec-butyl sites are sensitive to oxidation. Each carbon of the sec-butyl group is individually functionalized with strong preference for the methylene site in the mouse but not the housefly microsomal system. O-Methylene hydroxylation initiates spontaneous cage opening to form an aldehyde that undergoes metabolic reduction, ultimately yielding the same cyanobenzoate ester of 2,2-bis-(hydroxymethyl)-3-methylpentan-1-ol formed by direct hydrolysis. Houseflies injected with ({sup 3}H)COB form many if not all of the same metabolites, with major products being the aforementioned cyanobenzoate, the orthoester oxidized at the sec-butyl methylene site, and polar conjugates.

EUS-Guided Vascular Procedures: A Literature Review

Directory of Open Access Journals (Sweden)

Tomislav Bokun

2013-01-01

Full Text Available Endoscopic ultrasound (EUS is continuously stepping into the therapeutic arena, simultaneously evolving in different directions, such as the management of pancreatic and biliary diseases, celiac neurolysis, delivering local intratumoral therapy, and EUS-guided endosurgery. EUS-guided vascular procedures are also challenging, considering the variety of vascular pathology, proximity of the vascular structures to the GI tract wall, high resolution, and real-time guidance offering an attractive access route and precise delivery of the intervention. The literature on vascular therapeutic EUS demonstrates techniques for the management of upper GI variceal and nonvariceal bleeding, pseudoaneurysms, and coiling and embolization procedures, as well as the creation of intrahepatic portosystemic shunts. The paucity of studies, diversity of study designs, and the number of animal model studies hamper a systematic approach to the conclusion and decision making important to clinicians and healthcare policy makers. Nevertheless, theoretical benefits and findings up to date concerning technical feasibility, efficacy, and safety of the procedures drive further research and development in this rather young therapeutic arena.

The process of changing national malaria treatment policy: lessons from country-level studies.

Science.gov (United States)

Williams, Holly Ann; Durrheim, David; Shretta, Rima

2004-11-01

Widespread resistance of Plasmodium falciparum parasites to commonly used antimalarials, such as chloroquine, has resulted in many endemic countries considering changing their malaria treatment policy. Identifying and understanding the key influences that affect decision-making, and factors that facilitate or undermine policy implementation, is critical for improving the policy process and guiding resource allocation during this process. A historical review of archival documents from Malaŵi and data obtained from in-depth policy studies in four countries (Tanzania, South Africa, Kenya and Peru) that have changed malaria treatment policy provides important lessons about decision-making, the policy cycle and complex policy environment, while specifically identifying strategies successfully employed to facilitate policy-making and implementation. Findings from these country-level studies indicate that the process of malaria drug policy review should be institutionalized in endemic countries and based on systematically collected data. Key stakeholders need to be identified early and engaged in the process, while improved communication is needed on all levels. Although malaria drug policy change is often perceived to be a daunting task, using these and other proven strategies should assist endemic countries to tackle this challenge in a systematic fashion that ensures the development and implementation of the rational malaria drug policy.

Population health management guiding principles to stimulate collaboration and improve pharmaceutical care.

Science.gov (United States)

Steenkamer, Betty; Baan, Caroline; Putters, Kim; van Oers, Hans; Drewes, Hanneke

2018-04-09

Purpose A range of strategies to improve pharmaceutical care has been implemented by population health management (PHM) initiatives. However, which strategies generate the desired outcomes is largely unknown. The purpose of this paper is to identify guiding principles underlying collaborative strategies to improve pharmaceutical care and the contextual factors and mechanisms through which these principles operate. Design/methodology/approach The evaluation was informed by a realist methodology examining the links between PHM strategies, their outcomes and the contexts and mechanisms by which these strategies operate. Guiding principles were identified by grouping context-specific strategies with specific outcomes. Findings In total, ten guiding principles were identified: create agreement and commitment based on a long-term vision; foster cooperation and representation at the board level; use layered governance structures; create awareness at all levels; enable interpersonal links at all levels; create learning environments; organize shared responsibility; adjust financial strategies to market contexts; organize mutual gains; and align regional agreements with national policies and regulations. Contextual factors such as shared savings influenced the effectiveness of the guiding principles. Mechanisms by which these guiding principles operate were, for instance, fostering trust and creating a shared sense of the problem. Practical implications The guiding principles highlight how collaboration can be stimulated to improve pharmaceutical care while taking into account local constraints and possibilities. The interdependency of these principles necessitates effectuating them together in order to realize the best possible improvements and outcomes. Originality/value This is the first study using a realist approach to understand the guiding principles underlying collaboration to improve pharmaceutical care.

Education, Training and Skills in Innovation Policy

DEFF Research Database (Denmark)

Borrás, Susana; Edquist, Charles

2015-01-01

The main question that guides this paper is how governments are focusing (and must focus) on competence building (education, training and skills) when designing and implementing innovation policies. After a brief literature review, this paper suggests a typology of internal/external and individual....../organizational sources of competences that are related to innovation activities. This serves to examine briefly the most common initiatives that governments are taking in this regard. The paper identifies three overall deficiencies and imbalances in innovation systems in terms of education, training and skills...

Good Policy, Good Practice II. Improving Outcomes and Productivity in Higher Education: A Guide for Policymakers

Science.gov (United States)

Brenneman, Meghan Wilson; Callan, Patrick M.; Ewell, Peter T.; Finney, Joni E.; Jones, Dennis P.; Zis, Stacey

2010-01-01

This new edition of "Good Policy, Good Practice II" revises and updates the authors' 2007 publication. Like the earlier edition, it responds to one of the questions that is raised most frequently in the authors' work with public policy and education leaders as they begin to address the national and state imperatives to increase the proportion of…

Status report on the review of the 2200 m/sec fission constants

Energy Technology Data Exchange (ETDEWEB)

Good, W M

1968-05-15

The monitoring of the 2200 m/sec constants of the fissile nuclides has been a continuing activity of the IAEA. From the long-range point of view, such an activity should consist of occasional reviews to assure that the data and analytical methods are in fact the 'best that are currently available according to expert opinion. Such a review has just been concluded, by a group augmented in size from the first one of several years ago, to include representative members from USA and USSR. Because the meeting proper have so recently taken place and because of certain handicaps suffered from underestimating the magnitude of such a revision, no very complete written report is available at INDC meeting time. In order that the committee might reflect on the relative importance of this Agency activity at this time, Dr. Carl Westcott who coordinated the work has given permission to submit his unedited comments on the present status of the recent review.

Status report on the review of the 2200 m/sec fission constants

International Nuclear Information System (INIS)

Good, W.M.

1968-05-01

The monitoring of the 2200 m/sec constants of the fissile nuclides has been a continuing activity of the IAEA. From the long-range point of view, such an activity should consist of occasional reviews to assure that the data and analytical methods are in fact the 'best that are currently available according to expert opinion. Such a review has just been concluded, by a group augmented in size from the first one of several years ago, to include representative members from USA and USSR. Because the meeting proper have so recently taken place and because of certain handicaps suffered from underestimating the magnitude of such a revision, no very complete written report is available at INDC meeting time. In order that the committee might reflect on the relative importance of this Agency activity at this time, Dr. Carl Westcott who coordinated the work has given permission to submit his unedited comments on the present status of the recent review

Measuring and Maximising Research Impact in Applied Social Science Research Settings. Good Practice Guide

Science.gov (United States)

Stanwick, John; Hargreaves, Jo

2012-01-01

This guide describes the National Centre for Vocational Education Research (NCVER) approach to measuring impact using examples from its own case studies, as well as showing how to maximise the impact of applied social science research. Applied social science research needs to demonstrate that it is relevant and useful both to public policy and…