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Sample records for policy cep analyzed

  1. Statistical network analysis for analyzing policy networks

    DEFF Research Database (Denmark)

    Robins, Garry; Lewis, Jenny; Wang, Peng

    2012-01-01

    and policy network methodology is the development of statistical modeling approaches that can accommodate such dependent data. In this article, we review three network statistical methods commonly used in the current literature: quadratic assignment procedures, exponential random graph models (ERGMs...... has much to offer in analyzing the policy process....

  2. Analyzing personalized policies for online biometric verification.

    Science.gov (United States)

    Sadhwani, Apaar; Yang, Yan; Wein, Lawrence M

    2014-01-01

    Motivated by India's nationwide biometric program for social inclusion, we analyze verification (i.e., one-to-one matching) in the case where we possess similarity scores for 10 fingerprints and two irises between a resident's biometric images at enrollment and his biometric images during his first verification. At subsequent verifications, we allow individualized strategies based on these 12 scores: we acquire a subset of the 12 images, get new scores for this subset that quantify the similarity to the corresponding enrollment images, and use the likelihood ratio (i.e., the likelihood of observing these scores if the resident is genuine divided by the corresponding likelihood if the resident is an imposter) to decide whether a resident is genuine or an imposter. We also consider two-stage policies, where additional images are acquired in a second stage if the first-stage results are inconclusive. Using performance data from India's program, we develop a new probabilistic model for the joint distribution of the 12 similarity scores and find near-optimal individualized strategies that minimize the false reject rate (FRR) subject to constraints on the false accept rate (FAR) and mean verification delay for each resident. Our individualized policies achieve the same FRR as a policy that acquires (and optimally fuses) 12 biometrics for each resident, which represents a five (four, respectively) log reduction in FRR relative to fingerprint (iris, respectively) policies previously proposed for India's biometric program. The mean delay is [Formula: see text] sec for our proposed policy, compared to 30 sec for a policy that acquires one fingerprint and 107 sec for a policy that acquires all 12 biometrics. This policy acquires iris scans from 32-41% of residents (depending on the FAR) and acquires an average of 1.3 fingerprints per resident.

  3. Analyzing personalized policies for online biometric verification.

    Directory of Open Access Journals (Sweden)

    Apaar Sadhwani

    Full Text Available Motivated by India's nationwide biometric program for social inclusion, we analyze verification (i.e., one-to-one matching in the case where we possess similarity scores for 10 fingerprints and two irises between a resident's biometric images at enrollment and his biometric images during his first verification. At subsequent verifications, we allow individualized strategies based on these 12 scores: we acquire a subset of the 12 images, get new scores for this subset that quantify the similarity to the corresponding enrollment images, and use the likelihood ratio (i.e., the likelihood of observing these scores if the resident is genuine divided by the corresponding likelihood if the resident is an imposter to decide whether a resident is genuine or an imposter. We also consider two-stage policies, where additional images are acquired in a second stage if the first-stage results are inconclusive. Using performance data from India's program, we develop a new probabilistic model for the joint distribution of the 12 similarity scores and find near-optimal individualized strategies that minimize the false reject rate (FRR subject to constraints on the false accept rate (FAR and mean verification delay for each resident. Our individualized policies achieve the same FRR as a policy that acquires (and optimally fuses 12 biometrics for each resident, which represents a five (four, respectively log reduction in FRR relative to fingerprint (iris, respectively policies previously proposed for India's biometric program. The mean delay is [Formula: see text] sec for our proposed policy, compared to 30 sec for a policy that acquires one fingerprint and 107 sec for a policy that acquires all 12 biometrics. This policy acquires iris scans from 32-41% of residents (depending on the FAR and acquires an average of 1.3 fingerprints per resident.

  4. Analyzing Security-Enhanced Linux Policy Specifications

    National Research Council Canada - National Science Library

    Archer, Myla

    2003-01-01

    NSA's Security-Enhanced (SE) Linux enhances Linux by providing a specification language for security policies and a Flask-like architecture with a security server for enforcing policies defined in the language...

  5. Theories of State Analyzing the Policy Process,

    Science.gov (United States)

    1973-11-01

    Mean, early sociologists; William Graham Sumner; Kurt Lewin, the social psychologist who emphasized group cohesiveness in group dynamics; Wilfred ... Bion ; Leon Festinger, who studied "cognitive dissonance" Harold Kelley, Stanley Schachter and Dorwin Cartwright. 63 For application to policy-making in

  6. Cep63 and cep152 cooperate to ensure centriole duplication.

    Directory of Open Access Journals (Sweden)

    Nicola J Brown

    Full Text Available Centrosomes consist of two centrioles embedded in pericentriolar material and function as the main microtubule organising centres in dividing animal cells. They ensure proper formation and orientation of the mitotic spindle and are therefore essential for the maintenance of genome stability. Centrosome function is crucial during embryonic development, highlighted by the discovery of mutations in genes encoding centrosome or spindle pole proteins that cause autosomal recessive primary microcephaly, including Cep63 and Cep152. In this study we show that Cep63 functions to ensure that centriole duplication occurs reliably in dividing mammalian cells. We show that the interaction between Cep63 and Cep152 can occur independently of centrosome localisation and that the two proteins are dependent on one another for centrosomal localisation. Further, both mouse and human Cep63 and Cep152 cooperate to ensure efficient centriole duplication by promoting the accumulation of essential centriole duplication factors upstream of SAS-6 recruitment and procentriole formation. These observations describe the requirement for Cep63 in maintaining centriole number in dividing mammalian cells and further establish the order of events in centriole formation.

  7. Using game theory to analyze green stormwater infrastructure implementation policies

    Science.gov (United States)

    William, R. K.; Garg, J.; Stillwell, A. S.

    2017-12-01

    While green stormwater infrastructure is a useful approach in addressing multiple challenges facing the urban environment, little consensus exists on how to best incentivize its adoption by private landowners. Game theory, a field of study designed to model conflict and cooperation between two or more agents, is well-suited to address this policy question. We used a cooperative game theory framework to analyze the impacts of three different policy approaches frequently used to incentivize the uptake of green infrastructure by private landowners: municipal regulation, direct grants, and stormwater fees. The results indicate that municipal regulation leads to the greatest environmental benefits; however, the choice of "best" regulatory approach is dependent on a variety of different factors including political and financial considerations. Policy impacts are also highly dependent on agents' spatial positions within the stormwater network. This finding leads to important questions of social equity and environmental justice.

  8. CEP55 overexpression predicts poor prognosis in patients with locally advanced esophageal squamous cell carcinoma.

    Science.gov (United States)

    Jiang, Wenpeng; Wang, Zhou; Jia, Yang

    2017-01-01

    Development of esophageal squamous cell carcinoma (ESCC) involves alterations in multiple genes with corresponding proteins. Recent studies have demonstrated that centrosomal protein 55 (CEP55) shares certain features with oncogenes, and CEP55 overexpression is associated with the development and progression of malignant tumors. The present study aimed to analyze, for the first time, whether CEP55 expression is related to clinicopothalogic features in the esophageal squamous cell carcinoma (ESCC), as well as patient survival. A total of 110 patients with mid-thoracic ESCC who suffered from Ivor-Lewis were enrolled. The CEP55 expression profile of these patients in tumour tissues and corresponding healthy esophageal mucosa (CHEM) was detected by immunohistochemistry and semi-quantitative reverse transcription-polymerase chain reaction analyses. Correlations between CEP55 expression and clinicopathological factors were analyzed using χ 2 test. The log-rank test was employed to calculate survival rate. A Cox regression multivariate analysis was performed to determine independent prognostic factors. The results demonstrated that CEP55 expression in ESCC was significantly higher than that of CHEM (POverexpression of CEP55 was significantly associated with differentiation degree (P=0.022), T stage (P=0.019), lymph node metastasis (P=0.033), clinicopathological staging (P=0.002) and tumor recurrence (P=0.021) in locally advanced ESCC patients. In addition, CEP55 overexpression was significantly associated with reduced overall survival of patients after surgery (P=0.012). The 5-year survival rate of patients without CEP55 overexpression was significantly higher than that of patients with CEP55 overexpression (P=0.012). Therefore, these findings suggest that CEP55 overexpression correlates with poor prognosis in locally advanced ESCC patients.

  9. POLITICAL PSYCHOLOGY – NEW CHALLENGES IN ANALYZING FOREIGN POLICY

    Directory of Open Access Journals (Sweden)

    Karin MEGHEȘAN

    2016-06-01

    Full Text Available The art of governance, the relationship between the governed and the governing, the impact of a social and political system on coherent foreign policy-building is significantly influenced by the distribution of power and the type of decisional unit existent within the state. New subjects of study, such as political psychology, have proved their utility both in theoretical and practical study of international relations. Being a frontier subject, political psychology tries to offer answers to a number of questions regarding different issues among which the way character features influence the decision maker’s behavior, the role of the operational code in foreign policy and the utility of psychological profiles in the international relationships and in intelligence. Leading from the types of power distribution and decisional units existent in the professional literature, the present paper narrows the narrative and focuses on examining the importance of the individual level of analysis in explaining foreign policy decisions, analyzing the decision of the Russian Federation to veto the intervention of the international community in the Syrian civil conflict.

  10. A Rare Form of Retinal Dystrophy Caused by Hypomorphic Nonsense Mutations in CEP290

    Directory of Open Access Journals (Sweden)

    Susanne Roosing

    2017-08-01

    Full Text Available Purpose: To identify the gene defect and to study the clinical characteristics and natural course of disease in a family originally diagnosed with oligocone trichromacy (OT, a rare congenital cone dysfunction syndrome. Methods: Extensive clinical and ophthalmologic assessment was performed on two siblings with OT and long-term follow up data were analyzed. Subsequently, whole exome sequencing (WES and Sanger sequence analysis of CEP290 was performed in the two siblings. Additionally, the identified CEP290 mutations were analyzed in persons with achromatopsia (ACHM (n = 23 and autosomal recessive or isolated cone dystrophy (CD; n = 145. Results: In the first decade of life, the siblings were diagnosed with OT based on low visual acuity, photophobia, nystagmus, and absent cone response on electroretinography , but with normal color discrimination. Over time, the phenotype of OT evolved to a progressive degenerative disease without any CEP290-associated non-ocular features. In both siblings, two nonsense mutations (c.451C>T; p.(Arg151* and c.4723A>T; p.(Lys1575* in CEP290 were found. Previously, p.(Arg151* was demonstrated to induce nonsense-mediated alternative splicing events leading to intact open reading frames of the resulting mRNA products (p.(Leu148_Glu165del and p.(Leu148_Lys172del. mRNA analysis for p.(Lys1575* confirmed a suspected hypomorphic character, as exon 36 skipping was observed in a small fraction of CEP290 mRNA, resulting in a 36 aa in-frame deletion (p.(Glu1569_Trp1604del. No additional cases carrying these variants were identified in the ACHM and CD cohorts. Conclusions: Compound heterozygous hypomorphic mutations in CEP290 may lead to a rare form of cone-dominated retinal dystrophy, a novel phenotype belonging to the CEP290-associated spectrum of ciliopathies. These findings provide insight into the effect of CEP290 mutations on the clinical phenotype.

  11. Analyzing the influence of institutions on health policy development ...

    African Journals Online (AJOL)

    Background: During the 2001 election campaign, President Yoweri Museveni announced he was abolishing user fees for health services in Uganda. No analysis has been carried out to explain how he was able to initiate such an important policy decision without encountering any immediate barriers. Objective: To explain ...

  12. Cep70 and Cep131 contribute to ciliogenesis in zebrafish embryos

    Directory of Open Access Journals (Sweden)

    Carl Matthias

    2009-03-01

    Full Text Available Abstract Background The centrosome is the cell's microtubule organising centre, an organelle with important roles in cell division, migration and polarity. However, cells can divide and flies can, for a large part of development, develop without them. Many centrosome proteins have been identified but the roles of most are still poorly understood. The centrioles of the centrosome are similar to the basal bodies of cilia, hair-like extensions of many cells that have important roles in cell signalling and development. In a number of human diseases, such Bardet-Biedl syndrome, centrosome/cilium proteins are mutated, leading to polycystic kidney disease, situs inversus, and neurological problems, amongst other symptoms. Results We describe zebrafish (Danio rerio embryos depleted for two uncharacterised, centrosome proteins, Cep70 and Cep131. The phenotype of these embryos resembles that of zebrafish mutants for intraflagellar transport proteins (IFTs, with kidney and ear development affected and left-right asymmetry randomised. These organs and processes are those affected in Bardet-Biedl syndrome and other similar diseases. Like these diseases, the root cause of the phenotype lies, in fact, in dysfunctional cilia, which are shortened but not eliminated in several tissues in the morphants. Centrosomes and basal bodies, on the other hand, are present. Both Cep70 and Cep131 possess a putative HDAC (histone deacetylase interacting domain. However, we could not detect in yeast two-hybrid assays any interaction with the deacetylase that controls cilium length, HDAC6, or any of the IFTs that we tested. Conclusion Cep70 and Cep131 contribute to ciliogenesis in many tissues in the zebrafish embryo: cilia are made in cep70 and cep131 morphant zebrafish embryos but are shortened. We propose that the role of these centrosomal/basal body proteins is in making the cilium and that they are involved in determination of the length of the axoneme.

  13. Racial-Equity Policy as Leadership Practice: Using Social Practice Theory to Analyze Policy as Practice

    Science.gov (United States)

    Feldman, Sue; Winchester, Ilana

    2015-01-01

    This, primarily theoretical, paper takes up the longstanding problem of the disconnection between education policy and leadership practice. The authors propose the use of social practice theory as a tool for educational leaders at the state, school district, and school levels, to eliminate the disconnection between policy design and leadership…

  14. Analyzing social policy: multiple perspectives for critically understanding and evaluating policy

    National Research Council Canada - National Science Library

    O'Connor, Mary Katherine; Netting, F. Ellen

    2011-01-01

    "This unique volume outlines the different frameworks of policy analysis and explains how readers can use research and critical thinking skills to understand the different models from their formation...

  15. Analyzing social policy: multiple perspectives for critically understanding and evaluating policy

    National Research Council Canada - National Science Library

    O'Connor, Mary Katherine; Netting, F. Ellen

    2011-01-01

    ... and development to implementation. Approaching the topic from an analytical and research-based perspective, the authors help readers make better, informed choices for successfully dealing with the complexities of social policy...

  16. Analyzing the Contents of the Orders on Accounting Policy of Hotel Industry Enterprises

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    Kovalevskaya Nadezhda S.

    2017-10-01

    Full Text Available The article is aimed at carrying out an analysis of the contents of the orders on accounting policy of hotel industry enterprises and developing an optimal structure of the accounting policy parameters for the enterprises in this sphere. The contents of the «On accounting policy» orders was analyzed in terms of the organizational, technical and methodological divisions of the hotel industry enterprises of the Kharkiv region. In order to optimize the accounting process at the hotel industry enterprises, a structure of the hotel’s accounting policy parameters has been developed and recommendations have been made to improve the methodology of its design, which would facilitate rationalizing the formation of information resources to manage enterprise and improve performance without significant changes in the organizational structure and substantial financial investment.

  17. EE Cep observations requested for upcoming eclipse

    Science.gov (United States)

    Waagen, Elizabeth O.

    2014-07-01

    The AAVSO requests observations for the upcoming eclipse of EE Cephei, a long-period eclipsing variable. EE Cep has a period of 2,050 days, and shows strong variations in the eclipse light curve from one event to the next. Observations are needed to study the morphology of the upcoming eclipse, which will be used to better understand the shape of the eclipsing disk and how it precesses. Mid-eclipse is predicted to be August 23, 2014, but the early stages of the eclipse may begin as much as a month earlier. EE Cep is being observed by a number of amateur and professional astronomers using multiple telescopes at multiple wavelengths. Among these is a collaboration (see https://sites.google.com/site/eecep2014campaign/) headed by Cezary Galan at the Nicolaus Copernicus Astronomical Center in Poland; several individual AAVSO observers are already participating in this effort. The AAVSO is not currently a partner in that campaign, but all data submitted to the AAVSO will be publicly available. The AAVSO strongly encourages observers to begin following this star now, and to continue observations into October 2014 at least. Finder charts with sequence may be created using the AAVSO Variable Star Plotter (http://www.aavso.org/vsp). Observations should be submitted to the AAVSO International Database. See full Alert Notice for more details and observations.

  18. Theory of g-shift and linewidth in CeP excited state EPR

    International Nuclear Information System (INIS)

    Yang, D.; Cooper, B.R.; Huang, C.Y.; Sugawara, K.

    1979-01-01

    The Mori-Zwanzig memory function formalism was used to analyze the observed excited state EPR mode in CeP. The mixing of the Zeeman-split crystal-field excitation by the exchange, particularly among those with degenerate frequencies, yields a normal mode determining the observed low-frequency spectrum. This is illustrated by calculation with Heisenberg exchange which yields a single peak in qualitative agreement with the experiment

  19. Analyzing Market Economies from the Perspective of Information Production, Policy, and Self-Organized Equilibrium

    Directory of Open Access Journals (Sweden)

    C-Rene DOMINIQUE

    2016-04-01

    Full Text Available A modern market economy is an exceedingly complex, infinite-dimensional, stochastic dynamical system. The failure of mainstream economists to characterize its dynamics may well be due to its intractability. This paper argues that the characterization of its dynamics becomes almost trivial when it is analyzed from the perspective of information production. Whether its Jacobian matrix is specifiable or not, a Lyapunov spectrum can be constructed from which the potential Kolmogorov-Sinai or Shannon entropy can be assessed. However, a self-organized equilibrium must first obtain, and for that a suitable policy must be operational.

  20. CEP biomarkers as potential tools for monitoring therapeutics.

    Directory of Open Access Journals (Sweden)

    Kutralanathan Renganathan

    Full Text Available Carboxyethylpyrrole (CEP adducts are oxidative modifications derived from docosahexaenoate-containing lipids that are elevated in ocular tissues and plasma in age-related macular degeneration (AMD and in rodents exposed to intense light. The goal of this study was to determine whether light-induced CEP adducts and autoantibodies are modulated by pretreatment with AL-8309A under conditions that prevent photo-oxidative damage of rat retina. AL-8309A is a serotonin 5-HT1A receptor agonist.Albino rats were dark adapted prior to blue light exposure. Control rats were maintained in normal cyclic light. Rats were injected subcutaneously 3x with 10 mg/kg AL-8309A (2 days, 1 day and 0 hours before light exposure for 6 h (3.1 mW/cm(2, λ=450 nm. Animals were sacrificed immediately following light exposure and eyes, retinas and plasma were collected. CEP adducts and autoantibodies were quantified by Western analysis or ELISA.ANOVA supported significant differences in mean amounts of CEP adducts and autoantibodies among the light + vehicle, light + drug and dark control groups from both retina and plasma. Light-induced CEP adducts in retina were reduced ~20% following pretreatment with AL-8309A (n = 62 rats, p = 0.006 and retinal CEP immunoreactivity was less intense by immunohistochemistry. Plasma levels of light-induced CEP adducts were reduced at least 30% (n = 15 rats, p = 0.004 by drug pretreatment. Following drug treatment, average CEP autoantibody titer in light exposed rats (n = 22 was unchanged from dark control levels, and ~20% (p = 0.046 lower than in vehicle-treated rats.Light-induced CEP adducts in rat retina and plasma were significantly decreased by pretreatment with AL-8309A. These results are consistent with and extend previous studies showing AL-8309A reduces light-induced retinal lesions in rats and support CEP biomarkers as possible tools for monitoring the efficacy of select therapeutics.

  1. Quantum-CEP trademark for mixed waste processing

    International Nuclear Information System (INIS)

    Nahass, P.; Sekula-Moise, P.A.; Chanenchuk, C.A.

    1994-01-01

    No commercially available technology exists to effectively treat the hundreds of thousands of tons of mixed waste stored and generated in the United States and worldwide. Catalytic Extraction Processing (CEP) is an innovative flexible recycling technology which has inherent advantages for processing mixed wastes in a wide variety of chemical and physical forms. CEP uses a molten metal bath to completely dissociate feeds and recombine them with selected reactants to form useful products. Dissolved carbon in the metal bath creates a reducing atmosphere, readily converting hydrocarbons to synthesis gas, metals to alloys in their reduced state, and inorganics to an engineered ceramic phase. Process conditions can be manipulated to strongly favor partitioning of select radionuclides to a nonleachable vitreous phase, ready for final form disposal. Molten Metal Technology has adapted its CEP technology for radioactive processing and has delivered Quantum-CEP trademark units to customers for demonstration of mixed waste processing leading to commercial scale installations for reducing both private and government inventories. Agreements have also been reached to build commercial CEP facilities to recycle hazardous and industrial wastes

  2. Public policy and the people’s perception. Analyzing the relation between the shift in government policies and individual perceptions of the role of the government in China

    NARCIS (Netherlands)

    Stepan, M.; Reeskens, T.

    2012-01-01

    A perennial issue in political science is the relation between public policy and public opinion. While the research on this relation has mainly focused on advanced liberal democracies, this paper will analyze it in a quite different setting. Public policies in the People’s Republic of China have

  3. Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing.

    Science.gov (United States)

    Pagan, Julia K; Marzio, Antonio; Jones, Mathew J K; Saraf, Anita; Jallepalli, Prasad V; Florens, Laurence; Washburn, Michael P; Pagano, Michele

    2015-01-01

    An intercentrosomal linker keeps a cell's two centrosomes joined together until it is dissolved at the onset of mitosis. A second connection keeps daughter centrioles engaged to their mothers until they lose their orthogonal arrangement at the end of mitosis. Centriole disengagement is required to license centrioles for duplication. We show that the intercentrosomal linker protein Cep68 is degraded in prometaphase through the SCF(βTrCP) (Skp1-Cul1-F-box protein) ubiquitin ligase complex. Cep68 degradation is initiated by PLK1 phosphorylation of Cep68 on Ser 332, allowing recognition by βTrCP. We also found that Cep68 forms a complex with Cep215 (also known as Cdk5Rap2) and PCNT (also known as pericentrin), two PCM (pericentriolar material) proteins involved in centriole engagement. Cep68 and PCNT bind to different pools of Cep215. We propose that Cep68 degradation allows Cep215 removal from the peripheral PCM preventing centriole separation following disengagement, whereas PCNT cleavage mediates Cep215 removal from the core of the PCM to inhibit centriole disengagement and duplication.

  4. Analyzing Public Discourse: Using Media Content Analysis to Understand the Policy Process

    Science.gov (United States)

    Saraisky, Nancy Green

    2016-01-01

    One of the most basic and obvious sources of data for education policy analysis is text. This article discusses content analysis as an important part of the methodological toolbox for elucidating patterns and trends about education policy. Focusing specifically on media, I show how media content analysis can produce nuanced insights about the ways…

  5. Analyzing interdependencies between policy mixes and technological innovation systems : The case of offshore wind in Germany

    NARCIS (Netherlands)

    Reichardt, Kristin; Negro, Simona O.|info:eu-repo/dai/nl/300489021; Rogge, Karoline S.; Hekkert, Marko P.|info:eu-repo/dai/nl/143777629

    2016-01-01

    One key approach for studying emerging technologies in the field of sustainability transitions is that of technological innovation systems (TIS). While most TIS studies aim at deriving policy recommendations - typically by identifying system barriers - the actual role of these proposed policies in

  6. Pengaruh penggantian Bovine Serum Albumin (BSA dengan putih telur pada pengencer CEP-2 terhadap kualitas semen sapi Peranakan Ongole pada suhu penyimpanan 3-5oC

    Directory of Open Access Journals (Sweden)

    Nisa’us Sholikah

    2016-04-01

    Full Text Available Purpose of this research was to investigate the effect of Bovine Serum Albumin substitution by albumen on CEP-2 to semen quality Ongole CrossBred bull stored at 3-5oC. Research was conducted at Research Centre Beef Cattle Laboratory, Grati, Pasuruan on February 2016. Semen diluent was divided into two groups, there were P0 (90% CEP-2 + 10% Egg Yolk (EY; and P1 (90% CEP + 0.4% albumen + 10% EY. Data of the research were analyzed using paired design t test. The result showed that after eight days chilled preservation, percentage of motility P1 (47.4±10.9% was higher than P0 (47±9.2%. Percentage of viability P0 (83.1±1.9% was higher than P1 (81.3±1.5%. Percentage of abnormality P1 (3.6±0.4% was lower than P0 (3.8±0.3%. Total motile sperm count after six days chilled preservation was significantly higher in all treatments compared to the standard criteria of SNI 40% motile sperm/ml. The conclusion of this research was 0,4% albumen could replace the BSA capability on CEP-2. Keywords: CEP-2, Bovine Serum Albumin, chilled preservation, semen quality

  7. Opening talk of Didier Houssin, head of the direction of raw materials and hydrocarbons. Talk of Gerard Piketty, head of CEP and M at the CEP and M-COPREP day of October 10, 2000, corresponding to the 50. anniversary of FSH. Talk of Gilbert Rutman head of COPREP; Discours d'ouverture de Didier Houssin Directeur des matieres premieres et des hydrocarbures. Allocation de Gerard Piketty, president du CEP and M a la journee CEP and M-COPREP du 10 octobre 2000, marquant par ailleurs le 50. anniversaire du FSH. Discours de Gilbert Rutman president du COPREP

    Energy Technology Data Exchange (ETDEWEB)

    Houssin, D.; Piketty, G. [Comite d' Etudes Petrolieres et Marines, 92 - Paris la Defense (France); Rutman, G. [COPREP, (France)

    2000-07-01

    These articles report on the different opening talks of D. Housin, G. Piketty and G. Rutman. D. Houssin, head of the direction of raw materials and hydrocarbons, analyzes the main events of the petroleum industry for the year 2000 (oil crisis, oil prices, hydrocarbons market, para-petroleum sector etc..). G. Piketty, head of CEP and M, recalls some highlights of CEP and M's history, while G. Rutman, head of COPREP, briefly evokes the activities of his own technical committee. (J.S.)

  8. Analyzing policy support instruments and regulatory risk factors for wind energy deployment-A developers' perspective

    International Nuclear Information System (INIS)

    Luethi, Sonja; Praessler, Thomas

    2011-01-01

    A transition to a renewable energy system is high on the policy agenda in many countries. A promising energy source for a low-carbon energy future is wind. Policy-makers can attract wind energy development by providing attractive policy frameworks. This paper argues that apart from the level of financial support, both the risks stemming from the regulatory environment (legal security, administrative process and grid access) and the ability to finance projects play a critical role in determining the attractiveness of the development environment. It sheds light on how project developers trade off these different aspects and to what extent the attractiveness of a certain policy framework increases with the introduction of specific measures. Conjoint analysis is employed to provide empirical evidence on the preference of wind energy developers in the EU and the US. The analysis shows that developers' preferences are very similar across the studied regions and for different types of developers. Which policy measures could be most valuable depends on the specific existing environment. In some southeastern European countries, a reduction of administrative process duration may yield the highest utility gains, whereas, in the US, improvements in grid access regulation and an increase in remuneration levels may be more effective. - Highlights: → Paper suggests conjoint analysis as scenario tool for estimating potential effects of specific policy measures. → It provides a quantitative, empirical dataset of 119 onshore wind energy developers' preferences. → Results suggest that the aspects 'Legal security' and 'Remuneration' are important attributes. → Cluster analyses yields slightly different preferences for developers from EU and US.

  9. Frames of Reference: A Metaphor for Analyzing and Interpreting Attitudes of Environmental Policy Makers and Policy Influencers

    Science.gov (United States)

    Swaffield

    1998-07-01

    / The concept of frame of reference offers a potentially useful analytical metaphor in environmental management. This is illustrated by a case study in which attitudes of individuals involved in the management of trees in the New Zealand high country are classified into seven distinctive frames of reference. Some practical and theoretical implications of the use of the frame metaphor are explored, including its potential contribution to the emerg- ing field of communicative planning. KEY WORDS: Frames of reference; Environmental policy analysis; Metaphor; New Zealand high country

  10. Analyzing Agricultural Sustainability Indicators,Under Energy Subsidy Reduction Policy(Case Study of Qorveh Plain

    Directory of Open Access Journals (Sweden)

    H. Balali

    2016-03-01

    region, situated in the West of Iran. Materials and Methods: The statistical sample of this research includes all irrigated land of Qorveh as the studied area. A partial equilibrium model has been applied by mathematic programming approach in order to analyze the economic and environmental effects of reduction of energy subsidies for the agriculture sector in the studied area. For this purpose, through a survey, questionnaires were used in order to identify production coefficients of agriculture products and farmers' behavior during 2012-2013. Then relevant equations were used in mathematical programming framework with the aim of maximizing gross margin of agriculture activities in planning horizon by using GAMS 22.9. Results and Discussion: The results showed that by increasing energy price in policy scenarios of ES1 to ES7 the gross margin of agriculture activities decreases. Also, the results indicate that by implementation of scenarios SE1 and SE2, most economical and environmental indicators of agricultural sustainability will be improved and increasing energy prices as the mentioned policy scenarios has the most effect on GM_ELEC , GM_GAS, and NIT_H indicators and reduces them by 10.7%, 0.97% and 1.48%, respectively. In scenarios ES3 to ES5 with respect to scenarios ES1 and ES2, there is only 7% decrease in the NIT_H index. In scenario ES6, which grows electricity cost by 2.25 times and diesel fuel cost by 1.98 times, GM_ELEC, and GM_WA have the maximum decrease, namely 12.66% and 14.47%, respectively and WA_H has reached 9010 which shows an increase of 6.47%. In scenario ES7, with the exception of WA_H, GM_ELEC and GM_GAS other indicators decreased and this shows that the closer we keep to real energy prices, the more improvement we observe in the environmental indicators. Conclusions: Consequently, results showed that the reduction of energy subsidies leads to reductions in economic indicators of the study area, as total gross margins. Also, the results showed

  11. Analyzing the cost effectiveness of Santiago, Chile's policy of using urban forests to improve air quality

    Science.gov (United States)

    Francisco J. Escobedo; John E. Wagner; David J. Nowak; Carmen Luz De la Maza; Manuel Rodriguez; Daniel E. Crane

    2008-01-01

    Santiago, Chile has the distinction of having among the worst urban air pollution problems in Latin America. As part of an atmospheric pollution reduction plan, the Santiago Regional Metropolitan government defined an environmental policy goal of using urban forests to remove particulate matter less than 10 µm (PM10) in the Gran...

  12. Analyzing the Thai State Policy on Private Tutoring: The Prevalence of the Market Discourse

    Science.gov (United States)

    Lao, Rattana

    2014-01-01

    Private tutoring in academic subjects, which is provided for a fee and which takes place outside standard school hours, has become a global phenomenon. It is also very visible in Thailand. This paper draws on qualitative method including documentary analyses and semi-structured interviews with Thai policy elites, to understand the Thai state…

  13. Analyzing ICT Policy in K-12 Education in Sudan (1990-2016)

    Science.gov (United States)

    Tairab, Adam; Ronghuai, Huang

    2017-01-01

    The aim of this study of ICT policy in K-12 education in Sudan is to investigate the status of planning for technology in education and then determine how the advantage of ICT can best serve the educational system and improve educational outcomes. The study examined two plans for ICT in education, addition to an interview with the educational…

  14. Presenting a Framework to Analyze Local Climate Policy and Action in Small and Medium-Sized Cities

    Directory of Open Access Journals (Sweden)

    Thomas Hoppe

    2016-08-01

    Full Text Available Academic attention to local climate policy usually focuses on large-sized cities. Given the climate challenges ahead this seems unjustified. Small and medium-sized cities (SMCs deserve scholarly attention as well. The main question is: What factors influence climate change policy and local climate actions in SMCs? In this article we present an analytical framework to analyze climate change policy and local climate actions of SMCs. The framework addresses different aspects: policy-input, -throughput, -output, -outcome, characteristics of the local environment, local action arenas, influence by higher government levels, and interaction with climate change issue networks. The framework is used to analyze and compare four case studies of SMCs in the Dutch region of Twente (two urban and two rural municipalities, and addresses both adaptation and mitigation. Results show that both ‘localist’, ‘multi-level’ and issue network membership factors influence local climate policy action. Governance modes discerned concern mostly ‘governing by authority’ and ‘self-governing’. When reflecting on the role of SMCs in climate action the study revealed the importance of local capacity building schemes issued by provincial government, inter-municipal network collaboration, and the potential for local governments to mobilize and organize citizen action.

  15. Analyzing the Relationship Between Bus Pollution Policies and Morbidity Using a Quasi-Experiment

    OpenAIRE

    Ngo, Nicole S.

    2015-01-01

    Abstract Transit buses are used by millions of commuters every day, but they emit toxic diesel fumes. In 1988, the U.S. Environmental Protection Agency implemented emission standards for transit buses, which have been continually updated. Yet there is no quantitative evidence of the health benefits from these bus pollution policies due to data constraints and confounding variables. In this study, a quasi-experiment is used to exploit the geographic and temporal variation in emission standards...

  16. Analyzing the Safeguarding Our Communities Act: Patch for Patch Return Policy in Ontario

    Directory of Open Access Journals (Sweden)

    Soo-Min Kim

    2018-04-01

    Full Text Available Fentanyl is prescribed to patients suffering from severe chronic pain. Transdermal patches are the best mode of delivery for patients who have developed tolerance for opioids. However, used patches still contain fentanyl that can be extracted and misused, with potentially severe consequences. To address this issue, patients who are prescribed fentanyl patches in Ontario are now required to return previously dispensed patches to receive new patches under the Safeguarding Our Communities Act: Patch for Patch (P4P Return Policy. The problem is significant in Ontario because the province has the largest annual dispense rate of high-dose prescription fentanyl (112 units per 1,000 population in Canada even though the prevalence rate of chronic pain is lower than the national reported range (16.6% in Ontario versus 19.6 to 21.9% in other provinces, according to Gomes et al. 2014. The primary goal of this reform is to instill responsible use of fentanyl patches, and to improve safety for patients and the public by having a central disposal process. The reform was modeled after a community initiative that was pioneered in North Bay after receiving great support from health professional colleges and communities that voluntarily integrated the program prior to the introduction of Bill 33. Preliminary data suggest that the P4P policy is positively received by health professionals, although ongoing evaluation is needed to assess the effectiveness of the policy in reducing misuse and abuse of prescribed fentanyl patches.

  17. Analyzing the Relationship Between Bus Pollution Policies and Morbidity Using a Quasi-Experiment.

    Science.gov (United States)

    Ngo, Nicole S

    2015-09-01

    Transit buses are used by millions of commuters every day, but they emit toxic diesel fumes. In 1988, the U.S. Environmental Protection Agency implemented emission standards for transit buses, which have been continually updated. Yet there is no quantitative evidence of the health benefits from these bus pollution policies due to data constraints and confounding variables. In this study, a quasi-experiment is used to exploit the geographic and temporal variation in emission standards by using bus vintage as a proxy for bus emissions. This is accomplished using a unique, rich panel data set, which includes daily information on bus vintage and route for the New York City Transit bus fleet between 2006 and 2009. This information is merged with daily data on emergency department (ED) visits for respiratory illnesses, which include patients' residences at the census block level and exact admission date. Economic benefits resulting from these bus pollution policies are then estimated. Results show that stricter transit bus emission standards by the U.S. Environmental Protection Agency for particulate matter are associated with reduced ED visits for respiratory diseases for patients living within a few hundred feet of a bus route. These findings demonstrate that bus pollution policies have made critical improvements to public health.

  18. Mutations of CEP83 Cause Infantile Nephronophthisis and Intellectual Disability

    Science.gov (United States)

    Failler, Marion; Gee, Heon Yung; Krug, Pauline; Joo, Kwangsic; Halbritter, Jan; Belkacem, Lilya; Filhol, Emilie; Porath, Jonathan D.; Braun, Daniela A.; Schueler, Markus; Frigo, Amandine; Alibeu, Olivier; Masson, Cécile; Brochard, Karine; Hurault de Ligny, Bruno; Novo, Robert; Pietrement, Christine; Kayserili, Hulya; Salomon, Rémi; Gubler, Marie-Claire; Otto, Edgar A.; Antignac, Corinne; Kim, Joon; Benmerah, Alexandre; Hildebrandt, Friedhelm; Saunier, Sophie

    2014-01-01

    Ciliopathies are a group of hereditary disorders associated with defects in cilia structure and function. The distal appendages (DAPs) of centrioles are involved in the docking and anchoring of the mother centriole to the cellular membrane during ciliogenesis. The molecular composition of DAPs was recently elucidated and mutations in two genes encoding DAPs components (CEP164/NPHP15, SCLT1) have been associated with human ciliopathies, namely nephronophthisis and orofaciodigital syndrome. To identify additional DAP components defective in ciliopathies, we independently performed targeted exon sequencing of 1,221 genes associated with cilia and 5 known DAP protein-encoding genes in 1,255 individuals with a nephronophthisis-related ciliopathy. We thereby detected biallelic mutations in a key component of DAP-encoding gene, CEP83, in seven families. All affected individuals had early-onset nephronophthisis and four out of eight displayed learning disability and/or hydrocephalus. Fibroblasts and tubular renal cells from affected individuals showed an altered DAP composition and ciliary defects. In summary, we have identified mutations in CEP83, another DAP-component-encoding gene, as a cause of infantile nephronophthisis associated with central nervous system abnormalities in half of the individuals. PMID:24882706

  19. PENINGKATAN LIFE SKILL MAHASISWA KIMIA BERORIENTASI CHEMOENTREPRENEURSHIP (CEP MELALUI PEMBELAJARAN KOOPERATIF STAD

    Directory of Open Access Journals (Sweden)

    Ersanghono K.

    2011-02-01

    Full Text Available Based on the questionnaire to students UNNES Natural Sciences Department of Chemistry, professor of learning methods are still in the form of lectures and such very boring for students. Moreover, the material is an organic chemistry lecture course, especially the less favored and considered difficult by students because it is abstract, so it needs to be assisted visualization. It is therefore interesting to study as well as creativity and innovation fostering student learning and not so monotonous. The purpose of this study to determine the increase in life skill-oriented students Chemoentrepreneurship (CEP through the STAD cooperative learning. This research is a class act consisting of three cycles. Each stage consists of planning, implementation, observation, and reflection. The subjects of this study is a student of Chemistry Department of Education UNNES third semester. Focus examined in this study is the increase in life skill students (academic skills. The data obtained and analyzed using descriptive methods to determine the increase in student life skill. From the research, learning classical exhaustiveness increased from stage I (43%, stage II (50%, and stage III (86%. The average score life skill (cognitive aspects college students increased from cycle I, II, and III, respectively, 71.28; 78.21 and 89.15 .. Based on the results of this study can be concluded that the life skill students can be increased through the STAD cooperative learning-oriented CEP.

  20. Political attention to environmental issues: Analyzing policy punctuations in the Netherlands

    NARCIS (Netherlands)

    Breeman, G.E.; Timmermans, A.

    2009-01-01

    One of the most dramatized features in Al Gore's movie The Inconvenient Truth is the effects of a rising sea-level in the Netherlands. The film is an example of how the mobilization of bias in the Netherlands resulted in sudden high levels of attention for climate change problems. We analyze agenda

  1. The Social Process of Analyzing Real Water Resource Systems Plans and Management Policies

    Science.gov (United States)

    Loucks, Daniel

    2016-04-01

    Developing and applying systems analysis methods for improving the development and management of real world water resource systems, I have learned, is primarily a social process. This talk is a call for more recognition of this reality in the modeling approaches we propose in the papers and books we publish. The mathematical models designed to inform planners and managers of water systems that we see in many of our journals often seem more complex than they need be. They also often seem not as connected to reality as they could be. While it may be easier to publish descriptions of complex models than simpler ones, and while adding complexity to models might make them better able to mimic or resemble the actual complexity of the real physical and/or social systems or processes being analyzed, the usefulness of such models often can be an illusion. Sometimes the important features of reality that are of concern or interest to those who make decisions can be adequately captured using relatively simple models. Finding the right balance for the particular issues being addressed or the particular decisions that need to be made is an art. When applied to real world problems or issues in specific basins or regions, systems modeling projects often involve more attention to the social aspects than the mathematical ones. Mathematical models addressing connected interacting interdependent components of complex water systems are in fact some of the most useful methods we have to study and better understand the systems we manage around us. They can help us identify and evaluate possible alternative solutions to problems facing humanity today. The study of real world systems of interacting components using mathematical models is commonly called applied systems analyses. Performing such analyses with decision makers rather than of decision makers is critical if the needed trust between project personnel and their clients is to be developed. Using examples from recent and ongoing

  2. The Creation of Multimedia Resources to Support the Gaelic Athletic Association (GAA) Coach Education Programme (CEP)

    Science.gov (United States)

    Crotty, Yvonne; D'Arcy, Jimmy; Sweeney, David

    2016-01-01

    The Gaelic Athletic Association (GAA) is an Irish amateur sporting and cultural organisation. It represents in excess of 20,000 teams nationwide and is committed to supporting the development of players and coaches through its Coach Education Programme (CEP). A strategic goal of the CEP is to supplement the traditional field based coach education…

  3. Cep55 regulates embryonic growth and development by promoting Akt stability in zebrafish.

    Science.gov (United States)

    Jeffery, Jessie; Neyt, Christine; Moore, Wade; Paterson, Scott; Bower, Neil I; Chenevix-Trench, Georgia; Verkade, Heather; Hogan, Benjamin M; Khanna, Kum Kum

    2015-05-01

    CEP55 was initially described as a centrosome- and midbody-associated protein and a key mediator of cytokinesis. More recently, it has been implicated in PI3K/AKT pathway activation via an interaction with the catalytic subunit of PI3K. However, its role in embryonic development is unknown. Here we describe a cep55 nonsense mutant zebrafish with which we can study the in vivo physiologic role of Cep55. Homozygous mutants underwent extensive apoptosis by 24 hours postfertilization (hpf) concomitant with cell cycle defects, and heterozygous carriers were indistinguishable from their wild-type siblings. A similar phenotype was also observed in zebrafish injected with a cep55 morpholino, suggesting the mutant is a cep55 loss-of-function model. Further analysis revealed that Akt was destabilized in the homozygous mutants, which partially phenocopied Akt1 and Akt2 knockdown. Expression of either constitutively activated PIK3CA or AKT1 could partially rescue the homozygous mutants. Consistent with a role for Cep55 in regulation of Akt stability, treatment with proteasome inhibitor, MG132, partially rescued the homozygous mutants. Taken together, these results provide the first description of Cep55 in development and underline the importance of Cep55 in the regulation of Pi3k/Akt pathway and in particular Akt stability. © FASEB.

  4. Inhibition of Chk1 by CEP-3891 accelerates mitotic nuclear fragmentation in response to ionizing Radiation

    DEFF Research Database (Denmark)

    Syljuåsen, Randi G; Sørensen, Claus Storgaard; Nylandsted, Jesper

    2004-01-01

    The human checkpoint kinase Chk1 has been suggested as a target for cancer treatment. Here, we show that a new inhibitor of Chk1 kinase, CEP-3891, efficiently abrogates both the ionizing radiation (IR)-induced S and G(2) checkpoints. When the checkpoints were abrogated by CEP-3891, the majority (64...

  5. Bio-energy and youth: Analyzing the role of school, home, and media from the future policy perspectives

    International Nuclear Information System (INIS)

    Halder, Pradipta; Havu-Nuutinen, Sari; Pietarinen, Janne; Pelkonen, Paavo

    2011-01-01

    The study investigated the relationships between students' perceived information on bio-energy from school, home and media and their perceptions, attitudes, and knowledge regarding bio-energy. The study also analyzed the scope of future policies to raise awareness among young students about bio-energy. Data drawn from 495 Finnish students studying in ninth grade revealed that the students were more positive in their attitudes towards bio-energy compared to their perceptions of it. They were very positive about learning about bio-energy, while not so eager towards its utilization. It appeared that school, home, and media all had statistically significant effects on students' perceptions, attitudes, and level of knowledge related to bio-energy. Three principal components emerged from students' perceptions and attitudes towards bio-energy viz. 'motivation' revealing students' eagerness to know more about bio-energy; 'considering sustainability' revealing their criticality of forest bio-energy; and 'utilization' revealing their state of interests to use bio-energy. Bio-energy policies to be effective must consider the role of school, home, and media as important means to engage young students in bio-energy related discussions. It is also desirable to establish interactions between energy and educational policies to integrate the modern renewable energy concepts in the school curriculum.

  6. Demonstration projects of hydrogen mobility. The clean energy partnership (CEP)

    Energy Technology Data Exchange (ETDEWEB)

    Kirchner, Rene [TOTAL Deutschland GmbH / Clean Energy Partnership, Berlin (Germany)

    2013-06-01

    The Clean Energy Partnership (CEP)- an alliance of currently sixteen leading companies in Germany- shows that it may be doable to establish hydrogen as 'fuel of the future'. With Air Liquide, Berliner Verkehrsbetriebe (BVG), BMW, Daimler, EnBW, Ford, GM/Opel, Hamburger Hochbahn, Honda, Linde, Shell, Siemens, Total, Toyota, Vattenfall Europe and Volkswagen, the project partners include technology, oil and utility companies as well as major car manufacturers and two leading public transport companies of the two biggest German cities. The goal of CEP is to test using hydrogen- and fuel-cell technology on an everyday basis in the mobility sector with regard to individual traffic and public transport. Challenges are the use and supply of ''green'' hydrogen as well the serial production of hydrogen vehicles as well as the extension of the hydrogen filling station network. Nevertheless, Germany is a frontrunner when it comes to hydrogen mobility with currently 15 stations and 50% green hydrogen offered already today. (orig.)

  7. Analysis of T Tauri stars spectra: AS 353, DI Cep and RY Tau

    International Nuclear Information System (INIS)

    Krasnobabtsev, V.I.

    1982-01-01

    A study of the variations of the spectra of T Tauri-stars (AS 353, DI Cep and RY Tau) was carried out using the spectrograms obtained with the image-tube spectrograph at the 2.6 m telescope of the Crimean Astrophysical Observatory. Relationship between the variation of several emission lines was considered. For Di Cep a clear correlation between the intensity variation of the emission lines Ca II (H and K) and hydrogen line Hsub(#betta#) was found. On one night the activity of DI Cep looked like the outburst, that developed as displaced emission components in H and K Ca II lines. It was assumed that the variations of DI Cep and RY Tau from night to night might be probably due to heterogeneous surfaces of these stars. In compliance with the emission character in the Fe II lines, continuum spectrum stars (e.g. AS 353) should be distinguished from those with spectra having both emission lines and photospheric absorption lines (e.g. DI Cep). The difference is in the fact that the continuuum spectrum stars (such as AS 353) a certain correlation exists between the intensities of Fe II- and H-beta lines. In case of the CI Cep stars, no correlation exists between the intensity variation of the FeII- and H-beta lines even for the DI Cep proper

  8. Novel MtCEP1 peptides produced in vivo differentially regulate root development in Medicago truncatula.

    Science.gov (United States)

    Mohd-Radzman, Nadiatul A; Binos, Steve; Truong, Thy T; Imin, Nijat; Mariani, Michael; Djordjevic, Michael A

    2015-08-01

    Small, post-translationally modified and secreted peptides regulate diverse plant developmental processes. Due to low natural abundance, it is difficult to isolate and identify these peptides. Using an improved peptide isolation protocol and Orbitrap mass spectrometry, nine 15-amino-acid CEP peptides were identified that corresponded to the two domains encoded by Medicago truncatula CEP1 (MtCEP1). Novel arabinosylated and hydroxylated peptides were identified in root cultures overexpressing MtCEP1. The five most abundant CEP peptides were hydroxylated and these species were detected also in low amounts in vector control samples. Synthetic peptides with different hydroxylation patterns differentially affected root development. Notably, the domain 1 peptide hydroxylated at Pro4 and Pro11 (D1:HyP4,11) imparted the strongest inhibition of lateral root emergence when grown with 5mM KNO3 and stimulated the highest increase in nodule number when grown with 0mM KNO3. Inhibition of lateral root emergence by D1:HyP4,11 was not alleviated by removing peptide exposure. In contrast, the domain 2 peptide hydroxylated at Pro11 (D2:HyP11) increased stage III-IV lateral root primordium numbers by 6-fold (P emerge. Auxin addition at levels which stimulated lateral root formation in wild-type plants had little or no ameliorating effect on CEP peptide-mediated inhibition of lateral root formation or emergence. Both peptides increased and altered the root staining pattern of the auxin-responsive reporter GH3:GUS suggesting CEPs alter auxin sensitivity or distribution. The results showed that CEP primary sequence and post-translational modifications influence peptide activities and the improved isolation procedure effectively and reproducibly identifies and characterises CEPs. © The Author 2015. Published by Oxford University Press on behalf of the Society for Experimental Biology.

  9. C. elegans CEP-1/p53 and BEC-1 are involved in DNA repair.

    Directory of Open Access Journals (Sweden)

    Sandy Hoffman

    Full Text Available p53 is a transcription factor that regulates the response to cellular stress. Mammalian p53 functions as a tumor suppressor. The C. elegans p53, cep-1, regulates DNA-damage induced germline cell death by activating the transcription of egl-1 and ced-13. We used the C. elegans model to investigate how, in the whole animal, different forms of DNA damage can induce p53-dependent versus p53-independent cell death and DNA repair. DNA damage was induced by ultraviolet type C (UVC radiation, or 10-decarbamoyl mitomycin C (DMC, an agent known to induce mammalian p53-independent cell death. Wild-type or cep-1 loss-of-function mutant animals were assayed for germline cell death and DNA lesions. Wild-type animals displayed greater removal of UVC-lesions over time, whereas cep-1 mutant animals displayed increased UVC-lesion retention. The cep-1 mutation increased UVC-lesion retention directly correlated with a reduction of progeny viability. Consistent with DMC inducing p53-independent cell death in mammalian cells DMC induced a C. elegans p53-independent germline cell death pathway. To examine the influence of wild-type CEP-1 and DNA damage on C. elegans tumors we used glp-1(ar202gf/Notch germline tumor mutants. UVC treatment of glp-1 mutant animals activated the CEP-1 target gene egl-1 and reduced tumor size. In cep-1(gk138;glp-1(ar202gf animals, UVC treatment resulted in increased susceptibility to lesions and larger tumorous germlines. Interestingly, the partial knockdown of bec-1 in adults resulted in a CEP-1-dependent increase in germline cell death and an increase in DNA damage. These results strongly support cross-talk between BEC-1 and CEP-1 to protect the C. elegans genome.

  10. CEP57 mutation in a girl with mosaic variegated aneuploidy syndrome.

    Science.gov (United States)

    Pinson, Lucile; Mannini, Linda; Willems, Marjolaine; Cucco, Francesco; Sirvent, Nicolas; Frebourg, Thierry; Quarantotti, Valentina; Collet, Corinne; Schneider, Anouck; Sarda, Pierre; Geneviève, David; Puechberty, Jacques; Lefort, Geneviève; Musio, Antonio

    2014-01-01

    Mosaic variegated aneuploidy (MVA) is a rare autosomal recessive disorder characterized by constitutional aneuploidies. Mutations in BUB1B and CEP57 genes, which are involved in mitotic spindle and microtubule stabilization, respectively, are responsible for a subset of patients with MVA. To date, CEP57 mutations have been reported only in four probands. We report on a girl with this disorder due to c.915-925dup11 mutation in CEP57, which predicts p.Leu309ProfsX9 and review the literature in order to facilitate genotype-phenotype correlation. Rhizomelic shortening of the upper limbs, skull anomalies with conserved head circumference, and absence of tumor development could be features suggesting a need for molecular screening of the CEP57 gene in patients with this disorder. © 2013 Wiley Periodicals, Inc.

  11. Functional C-TERMINALLY ENCODED PEPTIDE (CEP) plant hormone domains evolved de novo in the plant parasite Rotylenchulus reniformis.

    Science.gov (United States)

    Eves-Van Den Akker, Sebastian; Lilley, Catherine J; Yusup, Hazijah B; Jones, John T; Urwin, Peter E

    2016-10-01

    Sedentary plant-parasitic nematodes (PPNs) induce and maintain an intimate relationship with their host, stimulating cells adjacent to root vascular tissue to re-differentiate into unique and metabolically active 'feeding sites'. The interaction between PPNs and their host is mediated by nematode effectors. We describe the discovery of a large and diverse family of effector genes, encoding C-TERMINALLY ENCODED PEPTIDE (CEP) plant hormone mimics (RrCEPs), in the syncytia-forming plant parasite Rotylenchulus reniformis. The particular attributes of RrCEPs distinguish them from all other CEPs, regardless of origin. Together with the distant phylogenetic relationship of R. reniformis to the only other CEP-encoding nematode genus identified to date (Meloidogyne), this suggests that CEPs probably evolved de novo in R. reniformis. We have characterized the first member of this large gene family (RrCEP1), demonstrating its significant up-regulation during the plant-nematode interaction and expression in the effector-producing pharyngeal gland cell. All internal CEP domains of multi-domain RrCEPs are followed by di-basic residues, suggesting a mechanism for cleavage. A synthetic peptide corresponding to RrCEP1 domain 1 is biologically active and capable of up-regulating plant nitrate transporter (AtNRT2.1) expression, whilst simultaneously reducing primary root elongation. When a non-CEP-containing, syncytia-forming PPN species (Heterodera schachtii) infects Arabidopsis in a CEP-rich environment, a smaller feeding site is produced. We hypothesize that CEPs of R. reniformis represent a two-fold adaptation to sustained biotrophy in this species: (i) increasing host nitrate uptake, whilst (ii) limiting the size of the syncytial feeding site produced. © 2016 The Authors. Molecular Plant Pathology Published by British Society for Plant Pathology and John Wiley & Sons Ltd.

  12. LONG-TERM LIGHT CURVE OF HIGHLY VARIABLE PROTOSTELLAR STAR GM CEP

    International Nuclear Information System (INIS)

    Xiao Limin; Kroll, Peter; Henden, Arne A.

    2010-01-01

    We present data from the archival plates at Harvard College Observatory and Sonneberg Observatory showing the field of the solar-type pre-main-sequence star GM Cep. A total of 186 magnitudes of GM Cep have been measured on these archival plates, with 176 in blue sensitivity, six in visible, and four in red. We combine our data with data from the literature and from the American Association of Variable Star Observers to depict the long-term light curves of GM Cep in both B and V wavelengths. The light curves span from 1895 until now, with two densely sampled regions (1935-1945 in the B band, and 2006 until now in the V band). The long-term light curves do not show any fast rise behavior as predicted by an accretion mechanism. Both the light curves and the magnitude histograms confirm the conclusion that the light curves are dominated by dips (possibly from extinction) superposed on some quiescence state, instead of outbursts caused by accretion flares. Our result excludes the possibility of GM Cep being a FUor, EXor, or McNeil's Nebula-type star. Several special cases of T Tauri stars were checked, but none of these light curves were compatible with that of GM Cep. The lack of periodicity in the light curve excludes the possibility of GM Cep being a KH 15D system.

  13. PENINGKATAN HASIL BELAJAR MAHASISWA PADA MATA KULIAH KIMIA DASAR II DENGAN MENGGUNAKAN PETA KONSEP BERORIENTASI CHEMOENTREPRENEURSHIP (CEP

    Directory of Open Access Journals (Sweden)

    Sri Nurhayati

    2012-02-01

    Full Text Available Based on the questionnaire to 52 students UNNES Department of Chemistry Faculty, teaching methods of lectures and lecturers are still such things are very boring for students. Moreover, the course material is primarily Basic Chemistry subjects that are less desirable and considered difficult by students because it is abstract, so it needs to be assisted visualization. It is therefore interesting to study as well as creativity and innovation fostering student learning and not so monotonous. The purpose of this study to determine the increase in the chemical and life skill learning of students with learning models CEP. This research is a class action that was implemented in three cycles. Each cycle consists of planning, implementation, observation, and reflection. The subjects of this study were students of Chemistry Department of Education UNNES the second half. The focus is investigated in this study is the result of learning and life skill development of students. The data obtained and analyzed using descriptive methods to determine the increase in the learning and life skill development of students. From the research, studying classical completeness increased from cycle I (44%, cycle II (82%, and cycle III (87%. The average scores of students cycle life skill I, II, and III, respectively 77%, 80% and 92% .. Based on these results we can conclude that the results of student learning and life skill can be improved through the implementation of CEP learning model.

  14. Characterizing the Cep E protostellar outflow: the oxygen chemistry

    Science.gov (United States)

    Gusdorf, Antoine

    2015-10-01

    With this proposal we aim at observing two positions in the Cep E protostellar outflow in OI and OH emission lines with the GREAT receiver. It is associated with another proposal by the same team to map the CII emission in this outflow associated to an intermediate mass protostar. These observations will be combined with Herschel observations of water line emission, and with previous CO data from various telescopes (IRAM 30m, PdBI, JCMT, Herschel, and most importantly, SOFIA). Their analysis will benefit from the important work initiated since the Cycle 0 of SOFIA, which has enabled our team to accurately link spatial structures (the jet, the outflow cavity, the terminal bowshock in the southern outflow lobe) to spectral components seen in the CO line profiles, and to precisely constrain the associated physical conditions by means of LVG methods or shock models. The goal is to precisely understand the water chemistry and to characterize the energetic impacts of the outflow based on a self-consistent and unique dataset that will allow us to fully characterize the associated shocks. Such a work is necessary also to understand the processes of formation of stars of intermediate mass with respect to their low-mass counterparts.

  15. The IL-8 protease SpyCEP/ScpC of group A Streptococcus promotes resistance to neutrophil killing.

    Science.gov (United States)

    Zinkernagel, Annelies S; Timmer, Anjuli M; Pence, Morgan A; Locke, Jeffrey B; Buchanan, John T; Turner, Claire E; Mishalian, Inbal; Sriskandan, Shiranee; Hanski, Emanuel; Nizet, Victor

    2008-08-14

    Interleukin-8 (IL-8) promotes neutrophil-mediated host defense through its chemoattractant and immunostimulatory activities. The Group A Streptococcus (GAS) protease SpyCEP (also called ScpC) cleaves IL-8, and SpyCEP expression is strongly upregulated in vivo in the M1T1 GAS strains associated with life-threatening systemic disease including necrotizing fasciitis. Coupling allelic replacement with heterologous gene expression, we show that SpyCEP is necessary and sufficient for IL-8 degradation. SpyCEP decreased IL-8-dependent neutrophil endothelial transmigration and bacterial killing, the latter by reducing neutrophil extracellular trap formation. The knockout mutant lacking SpyCEP was attenuated for virulence in murine infection models, and SpyCEP expression conferred protection to coinfecting bacteria. We also show that the zoonotic pathogen Streptococcus iniae possesses a functional homolog of SpyCEP (CepI) that cleaves IL-8, promotes neutrophil resistance, and contributes to virulence. By inactivating the multifunctional host defense peptide IL-8, the SpyCEP protease impairs neutrophil clearance mechanisms, contributing to the pathogenesis of invasive streptococcal infection.

  16. Phosphorylation of the centrosomal protein, Cep169, by Cdk1 promotes its dissociation from centrosomes in mitosis.

    Science.gov (United States)

    Mori, Yusuke; Inoue, Yoko; Taniyama, Yuki; Tanaka, Sayori; Terada, Yasuhiko

    2015-12-25

    Cep169 is a centrosomal protein conserved among vertebrates. In our previous reports, we showed that mammalian Cep169 interacts and collaborates with CDK5RAP2 to regulate microtubule (MT) dynamics and stabilization. Although Cep169 is required for MT regulation, its precise cellular function remains largely elusive. Here we show that Cep169 associates with centrosomes during interphase, but dissociates from these structures from the onset of mitosis, although CDK5RAP2 (Cep215) is continuously located at the centrosomes throughout cell cycle. Interestingly, treatment with purvalanol A, a Cdk1 inhibitor, nearly completely blocked the dissociation of Cep169 from centrosomes during mitosis. In addition, mass spectrometry analyses identified 7 phosphorylated residues of Cep169 corresponding to consensus phosphorylation sequence for Cdk1. These data suggest that the dissociation of Cep169 from centrosomes is controlled by Cdk1/Cyclin B during mitosis, and that Cep169 might regulate MT dynamics of mitotic spindle. Copyright © 2015 Elsevier Inc. All rights reserved.

  17. CEP action area studies : City of Yellowknife fleet review

    International Nuclear Information System (INIS)

    2006-01-01

    The City of Yellowknife maintains a fleet of vehicles and equipment used for public service. Yellowknife's Community Energy Plan (CEP) has a goal to reduce Yellowknife's fleet fuel consumption and greenhouse gas (GHG) emissions by 20 per cent within 10 years. This report examined current fuel consumption for the City of Yellowknife's fleet based on available data and examined options to reduce fleet fuel consumption. It also quantified the reduction in fuel consumption, GHG emissions, as well as the financial impacts of various options. An overview of the City of Yellowknife's fleet of vehicles and equipment was first provided, as well as calculated annual values for fuel consumption, GHG emissions, and energy consumption for the City of Yellowknife's fleet. Two fleet management case studies were presented. Fuel-efficient vehicles on the market that could provide an opportunity to replace some of the City of Yellowknife's fleet of light vehicles, and bylaw vehicles with fuel-efficient vehicles were discussed. These vehicles include hybrid vehicles, smart cars, compressed natural gas vehicles, and compressed-air vehicles. Equipment maintenance for tires, preventive, synthetic oils, and driver training programs were discussed. Anti-idling campaigns and technologies were also examined. The report concluded with a discussion of renewable fuels such as biodiesel and ethanol blended gasoline. Fleet fuel consumption, GHG and financial impacts were provided for each chapter heading. It was concluded that if all of the measures identified in the report were implemented, an overall decrease in GHG emissions of approximately 15 per cent would be achieved. 15 refs., 8 tabs., 8 figs

  18. Survey of Applications of Complex Event Processing (CEP in Health Domain

    Directory of Open Access Journals (Sweden)

    Nadeem Mahmood

    2017-12-01

    Full Text Available It is always difficult to manipulate the production of huge amount of data which comes from multiple sources and to extract meaningful information to make appropriate decisions. When data comes from various input resources, to get required streams of events form this complex input network, the one of the strong functionality of Business Intelligence (BI the Complex Event Processing (CEP is the appropriate solution for the above mention problems. Real time processing, pattern matching, stream processing, big data management, sensor data processing and many more are the application areas of CEP. Health domain itself is a multi-dimension domain such as hospital supply chain, OPD management, disease diagnostic, In-patient, out-patient management, and emergency care etc. In this paper, the main focus is to discuss the application areas of Complex Event Processing (CEP in health domain by using sensor device, such that how CEP manipulate health data set events coming from sensor devices such as blood pressure, heart rate, fall detection, sugar level, temperature or any other vital signs and how this systems respond to these events as quickly as possible. Different existing models and application using CEP are discussed and summarized according to different characteristics.

  19. Analyzing policy support instruments and regulatory risk factors for wind energy deployment-A developers' perspective

    Energy Technology Data Exchange (ETDEWEB)

    Luethi, Sonja, E-mail: sonja.luethi@unisg.ch [University of St. Gallen, 9000 St. Gallen (Switzerland); Praessler, Thomas [Potsdam Institute for Climate Impact Research (Germany)

    2011-09-15

    A transition to a renewable energy system is high on the policy agenda in many countries. A promising energy source for a low-carbon energy future is wind. Policy-makers can attract wind energy development by providing attractive policy frameworks. This paper argues that apart from the level of financial support, both the risks stemming from the regulatory environment (legal security, administrative process and grid access) and the ability to finance projects play a critical role in determining the attractiveness of the development environment. It sheds light on how project developers trade off these different aspects and to what extent the attractiveness of a certain policy framework increases with the introduction of specific measures. Conjoint analysis is employed to provide empirical evidence on the preference of wind energy developers in the EU and the US. The analysis shows that developers' preferences are very similar across the studied regions and for different types of developers. Which policy measures could be most valuable depends on the specific existing environment. In some southeastern European countries, a reduction of administrative process duration may yield the highest utility gains, whereas, in the US, improvements in grid access regulation and an increase in remuneration levels may be more effective. - Highlights: > Paper suggests conjoint analysis as scenario tool for estimating potential effects of specific policy measures. > It provides a quantitative, empirical dataset of 119 onshore wind energy developers' preferences. > Results suggest that the aspects 'Legal security' and 'Remuneration' are important attributes. > Cluster analyses yields slightly different preferences for developers from EU and US.

  20. The relationship of physical and chemical conditions of CEP diluent with egg yolk addition to bull spermatozoa quality before and after storage at temperaturof 4-5°C

    Science.gov (United States)

    Ducha, N.; Hariani, D.; Budijastuti, W.

    2018-01-01

    Storage of semen requires diluent to dilute semen and maintain sperm quality. One of the diluent for bull semen was CEP. The purpose of this study was to assess the association of bull spermatozoa quality with the physical and chemical conditions of CEP diluents with the addition of egg yolk before and after the storage process. The study used Limousin bull with 5 replications. The quality of spermatozoa included motility and viability. Physical and chemical conditions included the pH and osmolarity of the diluent. The motility of spermatozoa was observed under a light microscope with 200 X magnification at 37°C by two people. The viability of spermatozoa was observed under a light microscope with 400 X magnification with nigrosine eosin staining. Data were analyzed with ANOVA and continued Duncan’s test. Dilution pH was measured using pH indicator paper ranging from 6-8. The osmolarity of the diluent was measured by electrical osmolarity. The results showed that the addition of egg yolk in the CEP diluent decreased the pH and increased osmolartitas, but the quality of spermatozoa can be kept up to 8 days of storage. The conclusion in this study was the addition of egg yolk in the CEP diluent provided physical and chemical conditions that can maintain the quality of spermatozoa during storage at a temperature of 4-5 ° C.

  1. The Influence of State Policies on Critical Infrastructure Resilience: An Approach for Analyzing Transportation and Capital Investment

    Energy Technology Data Exchange (ETDEWEB)

    Wall, Thomas [Argonne National Lab. (ANL), Argonne, IL (United States); Trail, Jessica [Argonne National Lab. (ANL), Argonne, IL (United States); Gevondyan, Erna [Argonne National Lab. (ANL), Argonne, IL (United States); Phillips, Julia [Argonne National Lab. (ANL), Argonne, IL (United States); Ford, Janet [Argonne National Lab. (ANL), Argonne, IL (United States); Marks, James [Argonne National Lab. (ANL), Argonne, IL (United States)

    2017-09-01

    During times of crisis, communities and regions rely heavily on critical infrastructure systems to support their emergency management response and recovery activities. Therefore, the resilience of critical infrastructure systems to crises is a pivotal factor to a community’s overall resilience. Critical infrastructure resilience can be influenced by many factors, including State policies – which are not always uniform in their structure or application across the United States – were identified by the U.S. Department of Homeland Security as an area of particular interest with respect to their the influence on the resilience of critical infrastructure systems. This study focuses on developing an analytical methodology to assess links between policy and resilience, and applies that methodology to critical infrastructure in the Transportation Systems Sector. Specifically, this study seeks to identify potentially influential linkages between State transportation capital funding policies and the resilience of bridges located on roadways that are under the management of public agencies. This study yielded notable methodological outcomes, including the general capability of the analytical methodology to yield – in the case of some States – significant results connecting State policies with critical infrastructure resilience, with the suggestion that further refinement of the methodology may be beneficial.

  2. Mutations in the CEP290 (NPHP6) Gene Are a Frequent Cause of Leber Congenital Amaurosis

    Science.gov (United States)

    den Hollander, Anneke I.; Koenekoop, Robert K.; Yzer, Suzanne; Lopez, Irma; Arends, Maarten L.; Voesenek, Krysta E. J.; Zonneveld, Marijke N.; Strom, Tim M.; Meitinger, Thomas; Brunner, Han G.; Hoyng, Carel B.; van den Born, L. Ingeborgh; Rohrschneider, Klaus; Cremers, Frans P. M.

    2006-01-01

    Leber congenital amaurosis (LCA) is one of the main causes of childhood blindness. To date, mutations in eight genes have been described, which together account for ∼45% of LCA cases. We localized the genetic defect in a consanguineous LCA-affected family from Quebec and identified a splice defect in a gene encoding a centrosomal protein (CEP290). The defect is caused by an intronic mutation (c.2991+1655A→G) that creates a strong splice-donor site and inserts a cryptic exon in the CEP290 messenger RNA. This mutation was detected in 16 (21%) of 76 unrelated patients with LCA, either homozygously or in combination with a second deleterious mutation on the other allele. CEP290 mutations therefore represent one of the most frequent causes of LCA identified so far. PMID:16909394

  3. Desenvolvimento da dimensão educacional dos Comitês de Ética em Pesquisa (CEPs Desarrollo de la dimensión educacional de los Comités de Ética en Investigación (CEPs Development of the educational dimension of ethics of research committees (ERCs

    Directory of Open Access Journals (Sweden)

    Adriana Silva Barbosa

    2012-06-01

    66,7% de los investigadores participantes tuvieron alguna aproximación ética en su trayectoria académica. Estos datos indican que los CEIs necesitan mayor apoyo institucional e inversión para la consolidación de su dimensión educativo-consultiva.The importance of the educational and consulting nature of ethics of research committees (ERCs highlights the value of research which studies these dimensions in the committees. Aims: to analyze how ERCs have carried out their educational and consulting role; to learn whether advisors have some training in research ethics; to identify whether researchers had guidance about research ethics in their academic career. This is a quantitative and descriptive study approved by CEP/UESB under protocol 134/2009, carried out with 95 informants and analyzed by Software Sphinx. According to data obtained, nearly 71.5% research participants consider educational and consulting activities carried out by ERC infrequent or lacking; 60% participants have some ethical training in their academic career. These data show that ERCs need greater institutional support and funding in order to consolidate their educational-consulting dimension.

  4. In Vitro Modeling Using Ciliopathy-Patient-Derived Cells Reveals Distinct Cilia Dysfunctions Caused by CEP290 Mutations

    Directory of Open Access Journals (Sweden)

    Hiroko Shimada

    2017-07-01

    Full Text Available Mutations in CEP290, a transition zone protein in primary cilia, cause diverse ciliopathies, including Leber congenital amaurosis (LCA and Joubert-syndrome and related disorders (JSRD. We examined cilia biogenesis and function in cells derived from CEP290-LCA and CEP290-JSRD patients. CEP290 protein was reduced in LCA fibroblasts with no detectable impact on cilia; however, optic cups derived from induced pluripotent stem cells (iPSCs of CEP290-LCA patients displayed less developed photoreceptor cilia. Lack of CEP290 in JSRD fibroblasts resulted in abnormal cilia and decreased ciliogenesis. We observed selectively reduced localization of ADCY3 and ARL13B. Notably, Hedgehog signaling was augmented in CEP290-JSRD because of enhanced ciliary transport of Smoothened and GPR161. These results demonstrate a direct correlation between the extent of ciliogenesis defects in fibroblasts and photoreceptors with phenotypic severity in JSRD and LCA, respectively, and strengthen the role of CEP290 as a selective ciliary gatekeeper for transport of signaling molecules in and out of the cilium.

  5. The CXC Chemokine-degrading Protease SpyCep of Streptococcus pyogenes Promotes Its Uptake into Endothelial Cells*

    Science.gov (United States)

    Kaur, Simran Jeet; Nerlich, Andreas; Bergmann, Simone; Rohde, Manfred; Fulde, Marcus; Zähner, Dorothea; Hanski, Emanuel; Zinkernagel, Annelies; Nizet, Victor; Chhatwal, Gursharan S.; Talay, Susanne R.

    2010-01-01

    Streptococcus pyogenes expresses the LPXTG motif-containing cell envelope serine protease SpyCep (also called ScpC, PrtS) that degrades and inactivates the major chemoattractant interleukin 8 (IL-8), thereby impairing host neutrophil recruitment. In this study, we identified a novel function of SpyCep: the ability to mediate uptake into primary human endothelial cells. SpyCep triggered its uptake into endothelial cells but not into human epithelial cells originating from pharynx or lung, indicating an endothelial cell-specific uptake mechanism. SpyCep mediated cellular invasion by an endosomal/lysosomal pathway distinct from the caveolae-mediated invasion pathway of S. pyogenes. Recombinant expression and purification of proteolytically active SpyCep and a series of subfragments allowed functional dissection of the domains responsible for endothelial cell invasion and IL-8 degradation. The N-terminal PR domain was sufficient to mediate endothelial cell invasion, whereas for IL-8-degrading activity, the protease domain and the flanking A domain were required. A polyclonal rabbit serum raised against the recombinant protease efficiently blocked the invasion-mediating activity of SpyCep but not its proteolytic function, further indicating that SpyCep-mediated internalization is independent from its enzymatic activity. SpyCep may thus specifically mediate its own uptake as secreted protein into human endothelial cells. PMID:20562101

  6. The CXC chemokine-degrading protease SpyCep of Streptococcus pyogenes promotes its uptake into endothelial cells.

    Science.gov (United States)

    Kaur, Simran Jeet; Nerlich, Andreas; Bergmann, Simone; Rohde, Manfred; Fulde, Marcus; Zähner, Dorothea; Hanski, Emanuel; Zinkernagel, Annelies; Nizet, Victor; Chhatwal, Gursharan S; Talay, Susanne R

    2010-09-03

    Streptococcus pyogenes expresses the LPXTG motif-containing cell envelope serine protease SpyCep (also called ScpC, PrtS) that degrades and inactivates the major chemoattractant interleukin 8 (IL-8), thereby impairing host neutrophil recruitment. In this study, we identified a novel function of SpyCep: the ability to mediate uptake into primary human endothelial cells. SpyCep triggered its uptake into endothelial cells but not into human epithelial cells originating from pharynx or lung, indicating an endothelial cell-specific uptake mechanism. SpyCep mediated cellular invasion by an endosomal/lysosomal pathway distinct from the caveolae-mediated invasion pathway of S. pyogenes. Recombinant expression and purification of proteolytically active SpyCep and a series of subfragments allowed functional dissection of the domains responsible for endothelial cell invasion and IL-8 degradation. The N-terminal PR domain was sufficient to mediate endothelial cell invasion, whereas for IL-8-degrading activity, the protease domain and the flanking A domain were required. A polyclonal rabbit serum raised against the recombinant protease efficiently blocked the invasion-mediating activity of SpyCep but not its proteolytic function, further indicating that SpyCep-mediated internalization is independent from its enzymatic activity. SpyCep may thus specifically mediate its own uptake as secreted protein into human endothelial cells.

  7. The IL-8 Protease SpyCEP/ScpC of Group A Streptococcus Promotes Resistance to Neutrophil Killing

    Science.gov (United States)

    Zinkernagel, Annelies S.; Timmer, Anjuli M.; Pence, Morgan A.; Locke, Jeffrey B.; Buchanan, John T.; Turner, Claire E.; Mishalian, Inbal; Sriskandan, Shiranee; Hanski, Emanuel; Nizet, Victor

    2009-01-01

    SUMMARY Interleukin-8 (IL-8) promotes neutrophil-mediated host defense through its chemoattractant and immunostimulatory activities. The Group A Streptococcus (GAS) protease SpyCEP (also called ScpC) cleaves IL-8, and SpyCEP expression is strongly upregulated in vivo in the M1T1 GAS strains associated with life-threatening systemic disease including necrotizing fasciitis. Coupling allelic replacement with heterologous gene expression, we show that SpyCEP is necessary and sufficient for IL-8 degradation. SpyCEP decreased IL-8-dependent neutrophil endothelial transmigration and bacterial killing, the latter by reducing neutrophil extracellular trap formation. The knockout mutant lacking SpyCEP was attenuated for virulence in murine infection models, and SpyCEP expression conferred protection to coinfecting bacteria. We also show that the zoonotic pathogen Streptococcus iniae possesses a functional homolog of SpyCEP (Cepl) that cleaves IL-8, promotes neutrophil resistance, and contributes to virulence. By inactivating the multifunctional host defense peptide IL-8, the SpyCEP protease impairs neutrophil clearance mechanisms, contributing to the pathogenesis of invasive streptococcal infection. PMID:18692776

  8. Antisense Oligonucleotide (AON-based Therapy for Leber Congenital Amaurosis Caused by a Frequent Mutation in CEP290

    Directory of Open Access Journals (Sweden)

    Rob WJ Collin

    2012-01-01

    Full Text Available Leber congenital amaurosis (LCA is the most severe form of inherited retinal degeneration, with an onset in the first year of life. The most frequent mutation that causes LCA, present in at least 10% of individuals with LCA from North-American and Northern-European descent, is an intronic mutation in CEP290 that results in the inclusion of an aberrant exon in the CEP290 mRNA. Here, we describe a genetic therapy approach that is based on antisense oligonucleotides (AONs, small RNA molecules that are able to redirect normal splicing of aberrantly processed pre-mRNA. Immortalized lymphoblastoid cells of individuals with LCA homozygously carrying the intronic CEP290 mutation were transfected with several AONs that target the aberrant exon that is incorporated in the mutant CEP290 mRNA. Subsequent RNA isolation and reverse transcription-PCR analysis revealed that a number of AONs were capable of almost fully redirecting normal CEP290 splicing, in a dose-dependent manner. Other AONs however, displayed no effect on CEP290 splicing at all, indicating that the rescue of aberrant CEP290 splicing shows a high degree of sequence specificity. Together, our data show that AON-based therapy is a promising therapeutic approach for CEP290-associated LCA that warrants future research in animal models to develop a cure for this blinding disease.

  9. Techniques for analyzing the impacts of certain electric-utility ratemaking and regulatory-policy concepts. Regulatory laws and policies. [State by state

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-08-01

    This report is a legal study prepared to provide a review of the substantive and procedural laws of each regulatory jurisdiction that may affect implementation of the PURPA standards, and to summarize the current state of consideration and implementation of policies and rate designs similar or identical to the PURPA standards by state regulatory agencies and nonregulated utilities. This report is divided into three sections. The first section, the Introduction, summarizes the standards promulgated by PURPA and the results of the legal study. The second section, State Regulatory Law and Procedure, summarizes for each state or other ratemaking jurisdiction: (1) general constitutional and statutory provisions affecting utility rates and conditions of service; (2) specific laws or decisions affecting policy or rate design issues covered by PURPA standards; and (3) statutes and decisions governing administrative procedures, including judicial review. A chart showing actions taken on the policy and rate design issues addressed by PURPA is also included for each jurisdiction, and citations to relevant authorities are presented for each standard. State statutes or decisions that specifically define a state standard similar or identical to a PURPA standard, or that refer to one of the three PURPA objectives, are noted. The third section, Nonregulated Electric Utilities, summarizes information available on nonregulated utilities, i.e., publicly or cooperatively owned utilities which are specifically exempted from state regulation by state law.

  10. A sequential input–output framework to analyze the economic and environmental implications of energy policies: Gas taxes and fuel subsidies

    International Nuclear Information System (INIS)

    Choi, Jun-Ki; Bakshi, Bhavik R.; Hubacek, Klaus; Nader, Jordan

    2016-01-01

    Highlights: • Novel framework integrates monetary and physical changes in sequential input–output analysis. • Estimate economy-wide environmental changes as a result of combined energy policies. • Life cycle resource consumption and emission data for the U.S. economic sectors are adopted. • Ecosystem impacts could increase as a consequence of combined gasoline tax and bio-subsidy. - Abstract: A novel generic sequential input–output framework is developed to model the economy-wide changes in resource consumption and environmental emissions as a result of combined applied energy policies, e.g. taxes for non-renewables and subsidies for renewables. Many input–output analyses are based on a single period analysis. However, in the case of analyzing the effects of multiple policy interventions over time, the input–output table reflecting the state of the economy before the energy policy was introduced cannot be used for analyzing the economic effects of another policy intervention in the next time period since the monetary and physical transaction of commodities have already been affected. To show the efficacy of the proposed method, a case study is developed that introduced a gasoline tax and earmarks the revenues to subsidize biofuel production in the subsequent time period in the United States. In order to assess the change of environmental indicators after sequential policy interventions, Ecologically-based Life Cycle Analysis (ECO-LCA) inventories which include data on resource consumption, emissions, ecosystem goods and services related to the U.S. economic sectors are adopted. The environmentally extended input–output framework is ideally suited to model the interlinkages between a range for environmental indicators and detailed structural economic information at the sector level for the analysis of energy policies. The proposed framework can be utilized as a tool for leveraging the energy and environmental policy trade-off decisions which

  11. Energy and the global warming issue in developing countries: analyzing the incidence of the fuel carbon tax and its policy implications

    International Nuclear Information System (INIS)

    Siddayao, C.M.; Percebois, J.R.

    1992-01-01

    By changing the natural environment, energy resource use has repercussions for human welfare. So do policies that are proposed to deal with concerns over global climate warming, particularly with respect to carbon dioxide (CO 2 ). Among the major policy options identified are reduction of emission from fossil fuel consumption, as well as more rigorous forest management to avoid further deforestation. The basic approach to reducing carbon emissions from fossil fuels is through the efficient use of energy. Fuel switching, pollution prevention technologies, and the 'polluter pays' principle are also among the policy strategies often discussed. One of the proposed economic policy instruments in the 'polluter pays' category that could lead to more efficient use of energy and at the same time deal with the CO 2 problem is the carbon tax. This paper will focus on the incidence of the tax in the different sectors of a developing country and suggest the key issues in analyzing this incidence. This introduction will include a brief background discussion on the greenhouse gas (GHG) issue which has led to the proposal for the carbon tax. In section II, the incidence of the carbon tax will be reviewed. In section III, the key analytical issues for analyzing incidence of the tax on a sector-by-sector analysis of a national tax will be raised. In this version of this paper, the intended quantitative analysis is not presented; we hope to have partial results by the time of conference. 31 refs., 1 fig., 3 tabs

  12. Mutation in CEP63 co-segregating with developmental dyslexia in a Swedish family.

    Science.gov (United States)

    Einarsdottir, Elisabet; Svensson, Idor; Darki, Fahimeh; Peyrard-Janvid, Myriam; Lindvall, Jessica M; Ameur, Adam; Jacobsson, Christer; Klingberg, Torkel; Kere, Juha; Matsson, Hans

    2015-11-01

    Developmental dyslexia is the most common learning disorder in children. Problems in reading and writing are likely due to a complex interaction of genetic and environmental factors, resulting in reduced power of studies of the genetic factors underlying developmental dyslexia. Our approach in the current study was to perform exome sequencing of affected and unaffected individuals within an extended pedigree with a familial form of developmental dyslexia. We identified a two-base mutation, causing a p.R229L amino acid substitution in the centrosomal protein 63 kDa (CEP63), co-segregating with developmental dyslexia in this pedigree. This mutation is novel, and predicted to be highly damaging for the function of the protein. 3D modelling suggested a distinct conformational change caused by the mutation. CEP63 is localised to the centrosome in eukaryotic cells and is required for maintaining normal centriole duplication and control of cell cycle progression. We found that a common polymorphism in the CEP63 gene had a significant association with brain white matter volume. The brain regions were partly overlapping with the previously reported region influenced by polymorphisms in the dyslexia susceptibility genes DYX1C1 and KIAA0319. We hypothesise that CEP63 is particularly important for brain development and might control the proliferation and migration of cells when those two events need to be highly coordinated.

  13. Distorted cyclotron line profile in Cep X-4 as observed by NuSTAR

    DEFF Research Database (Denmark)

    Fürst, F.; Pottschmidt, K.; Miyasaka, H.

    2015-01-01

    We present spectral analysis of NuSTAR and Swift observations of Cep X-4 during its outburst in 2014. We observed the source once during the peak of the outburst and once during the decay, finding good agreement in the spectral shape between the observations. We describe the continuum using...

  14. New insights into the near-IR spectroscopy of the young variable PV Cep

    Science.gov (United States)

    Lorenzetti, D.; Giannini, T.; Antoniucci, S.; Kopatskaya, E. N.; Larionov, V.; Arkharov, A. A.; Di Paola, A.; Nisini, B.

    2015-08-01

    During our EXor monitoring programme dubbed EXORCISM (EXOR OptiCal and Infrared Systematic Monitoring - Antoniucci et al. 2013 PPVI, Lorenzetti et al. 2007 ApJ 665, 1182), we have been observing the variable source PV Cep (ATel #1256; #1607).

  15. The cep quorum-sensing system of Burkholderia cepacia H111 controls biofilm formation and swarming motility

    DEFF Research Database (Denmark)

    Huber, B.; Riedel, K.; Hentzer, Morten

    2001-01-01

    Burkholderia cepacia and Pseudomonas aeruginosa often co-exist as mixed biofilms in the lungs of patients suffering from cystic fibrosis (CF). Here, the isolation of random mini-Tn5 insertion mutants of B. cepacia H111 defective in biofilm formation on an abiotic surface is reported....... It is demonstrated that one of these mutants no longer produces N-acylhomoserine lactones (AHLs) due to an inactivation of the cepR gene. cepR and the cepI AHL synthase gene together constitute the cep quorum-sensing system of B. cepacia. By using a gene replacement method, two defined mutants, H111-I and H111-R......, were constructed in which cepI and cepR, respectively, had been inactivated. These mutants were used to demonstrate that biofilm formation by B. cepacia H111 requires a functional cep quorum-sensing system. A detailed quantitative analysis of the biofilm structures formed by wild-type and mutant...

  16. Analyzing the sources and nature of influence: how the Avahan program used evidence to influence HIV/AIDS prevention policy in India.

    Science.gov (United States)

    Tran, Nhan T; Bennett, Sara C; Bishnu, Rituparna; Singh, Suneeta

    2013-04-17

    Major investments by development partners in low- and middle-income countries (LMICs) often seek to develop a supportive policy environment. There is limited knowledge about the mechanisms that development partners use to influence government policy, or which mechanisms are effective. This study assessed the influence of Avahan, a large HIV/AIDS prevention program in India supported by the Bill and Melinda Gates Foundation, on the development of HIV/AIDS policies in India, particularly the National AIDS Control Program III (NACP III). A retrospective assessment of the contributions of Avahan to the development of NACP III was conducted based upon document review and in-depth interviews with key informants, including Avahan staff and staff of implementing partners. This assessment was carried out within a framework centered on three domains: evidence considered by policy and decision-makers; the channel through which influence is exerted; and the target audience for influence. Respondents identified a number of respects in which Avahan influenced NACP III policy, notably, Avahan influenced perception of the feasibility of scaling up services (through a demonstration effect) and Avahan, along with others, helped ensure a strong focus on targeted interventions. Overall Avahan's influence was greatest during policy implementation. While the extent to which research evidence generated by Avahan influenced NACP III was limited, best practice evidence generated by Avahan, including the lessons learned from routine implementation and management, contributed significantly to NACP III. This was largely due to the credibility Avahan had established and strategic 'inside track' communications. While studies of knowledge translation typically focus primarily on scientific evidence, this study suggests that other forms of evidence, notably best practice evidence derived from program experience, and disseminated through personal communication, were particularly influential. The

  17. Desenvolvimento da dimensão educacional dos Comitês de Ética em Pesquisa (CEPs)

    OpenAIRE

    Silva Barbosa,Adriana; Silva de Oliveira Boery,Rita Narriman; Nagib Boery,Eduardo; Ferrari,Márcio Roger

    2012-01-01

    A importância do caráter educativo e consultivo dos Comitês de Ética em Pesquisa (CEPs) torna relevante pesquisas que busquem investigar essas dimensões dos referidos comitês. Objetivos: analisar como os CEPs têm realizado seu papel educacional e consultivo; averiguar se os pareceristas têm alguma formação sobre ética em pesquisa; identificar se os pesquisadores tiveram orientações sobre ética em pesquisa em sua trajetória acadêmica. Estudo quantitativo e descritivo, aprovado pelo CEP/UESB so...

  18. Techniques for analyzing the impacts of certain electric-utility ratemaking and regulatory-policy concepts. Glossary

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-08-01

    This document, Glossary, is the first in a series of reports to identify, describe, and apply techniques for analyzing the impacts of certain electric utility concepts. This report was developed with a focus on the currently evolving issues of ratemaking, especially as they might be expected to arise under Sections 101, 111, 113, 114, 131, 132, and 210 of the P.U.R.P.A. of 1978. Because the evolutionary process of ratemaking has led to multiple proceedings and changes of inference in some terms, the glossary attempts to delineate these changes where appropriate. Definitions not uniquely related to ratemaking are included if they are likely to be used in ratemaking proceedings. To avoid unnecessary duplication of effort and expense, the compilers relied heavily on previously developed, publicly available glossaries and definitions developed by organizations such as Edison Electric Institute, the Electric Power Research Institute, and the Institute of Electrical and Electronics Engineers. Existing definitions were revised and new ones were developed as appropriate.

  19. NOAA JPSS Visible Infrared Imaging Radiometer Suite (VIIRS) Cloud Effective Particle Size (CEPS) Environmental Data Record (EDR) from IDPS

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset contains a high quality operational Environmental Data Record (EDR) of Cloud Effective Particle Size (CEPS) from the Visible Infrared Imaging Radiometer...

  20. Cyclic electrowinning/precipitation (CEP) system for the removal of heavy metal mixtures from aqueous solutions.

    Science.gov (United States)

    Grimshaw, Pengpeng; Calo, Joseph M; Hradil, George

    2011-11-15

    The description and operation of a novel cyclic electrowinning/precipitation (CEP) system for the simultaneous removal of mixtures of heavy metals from aqueous solutions are presented. CEP combines the advantages of electrowinning in a spouted particulate electrode (SPE) with that of chemical precipitation and redissolution, to remove heavy metals at low concentrations as solid metal deposits on particulate cathode particles without exporting toxic metal precipitate sludges from the process. The overall result is very large volume reduction of the heavy metal contaminants as a solid metal deposit on particles that can either be safely discarded as such, or further processed to recover particular metals. The performance of this system is demonstrated with data on the removal of mixtures of copper, nickel, and cadmium from aqueous solutions.

  1. TRIGONOMETRIC PARALLAXES OF MASSIVE STAR-FORMING REGIONS. II. CEP A AND NGC 7538

    International Nuclear Information System (INIS)

    Moscadelli, L.; Reid, M. J.; Menten, K. M.; Brunthaler, A.; Xu, Y.; Zheng, X. W.

    2009-01-01

    We report trigonometric parallaxes for the sources NGC 7538 and Cep A, corresponding to distances of 2.65 +0.12 -0.11 and 0.70 +0.04 -0.04 kpc, respectively. The distance to NGC 7538 is considerably smaller than its kinematic distance and places it in the Perseus spiral arm. The distance to Cep A is also smaller than its kinematic distance and places it in the L ocalarm or spur. Combining the distance and proper motions with observed radial velocities gives the location and full space motion of the star-forming regions. We find significant deviations from circular galactic orbits for these sources: both sources show large peculiar motions (greater than 10 km s -1 ) counter to galactic rotation and NGC 7538 has a comparable peculiar motion toward the Galactic center.

  2. Use of the 10-Group Classification System to analyze how the population control policy change in China has affected cesarean delivery.

    Science.gov (United States)

    Zhang, Yihui; Gu, Ning; Wang, Zhiqun; Zheng, Mingming; Hu, Yali; Dai, Yimin

    2017-08-01

    To analyze the initial effect following the relaxation of China's population control policy on the cesarean delivery (CD) rate using the 10-Group Classification System (TGCS). A retrospective study included all deliveries at a center in Nanjing, China, during 2014-2015. The deliveries were classified using the TGCS. The obstetric populations and the CD rates in each group were compared between 2014 and 2015. Overall, 11 006 deliveries were analyzed. The overall CD rate increased from 28.3% (1623/5737) in 2014 to 33.8% (1782/5269) in 2015 (Pone-third of all CDs-were nulliparous women with a single cephalic term pregnancy and induced labor or prelabor CD (group 2); the CD rate in this group increased from 27.2% to 31.4%. Moreover, the proportion of women with a single cephalic term pregnancy with previous CD (group 5) steeply increased from 6.4% to 10.4% of all deliveries; the CD rate in this group during 2014-2015 was 76.6%. With China ending its one-child policy, the characteristics of the obstetric population changed. Women with a single cephalic term pregnancy with previous CD were the largest contributor to the CD rate increase. © 2017 International Federation of Gynecology and Obstetrics.

  3. Midbody Targeting of the ESCRT Machinery by a Noncanonical Coiled Coil in CEP55

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Hyung Ho; Elia, Natalie; Ghirlando, Rodolfo; Lippincott-Schwartz, Jennifer; Hurley, James H. (NIH)

    2008-11-14

    The ESCRT (endosomal sorting complex required for transport) machinery is required for the scission of membrane necks in processes including the budding of HIV-1 and cytokinesis. An essential step in cytokinesis is recruitment of the ESCRT-I complex and the ESCRT-associated protein ALIX to the midbody (the structure that tethers two daughter cells) by the protein CEP55. Biochemical experiments show that peptides from ALIX and the ESCRT-I subunit TSG101 compete for binding to the ESCRT and ALIX-binding region (EABR) of CEP55. We solved the crystal structure of EABR bound to an ALIX peptide at a resolution of 2.0 angstroms. The structure shows that EABR forms an aberrant dimeric parallel coiled coil. Bulky and charged residues at the interface of the two central heptad repeats create asymmetry and a single binding site for an ALIX or TSG101 peptide. Both ALIX and ESCRT-I are required for cytokinesis, which suggests that multiple CEP55 dimers are required for function.

  4. CEP-1, the Caenorhabditis elegans p53 homolog, mediates opposing longevity outcomes in mitochondrial electron transport chain mutants.

    Directory of Open Access Journals (Sweden)

    Aiswarya Baruah

    2014-02-01

    Full Text Available Caenorhabditis elegans CEP-1 and its mammalian homolog p53 are critical for responding to diverse stress signals. In this study, we found that cep-1 inactivation suppressed the prolonged lifespan of electron transport chain (ETC mutants, such as isp-1 and nuo-6, but rescued the shortened lifespan of other ETC mutants, such as mev-1 and gas-1. We compared the CEP-1-regulated transcriptional profiles of the long-lived isp-1 and the short-lived mev-1 mutants and, to our surprise, found that CEP-1 regulated largely similar sets of target genes in the two mutants despite exerting opposing effects on their longevity. Further analyses identified a small subset of CEP-1-regulated genes that displayed distinct expression changes between the isp-1 and mev-1 mutants. Interestingly, this small group of differentially regulated genes are enriched for the "aging" Gene Ontology term, consistent with the hypothesis that they might be particularly important for mediating the distinct longevity effects of CEP-1 in isp-1 and mev-1 mutants. We further focused on one of these differentially regulated genes, ftn-1, which encodes ferritin in C. elegans, and demonstrated that it specifically contributed to the extended lifespan of isp-1 mutant worms but did not affect the mev-1 mutant lifespan. We propose that CEP-1 responds to different mitochondrial ETC stress by mounting distinct compensatory responses accordingly to modulate animal physiology and longevity. Our findings provide insights into how mammalian p53 might respond to distinct mitochondrial stressors to influence cellular and organismal responses.

  5. Cep169, a Novel Microtubule Plus-End-Tracking Centrosomal Protein, Binds to CDK5RAP2 and Regulates Microtubule Stability.

    Directory of Open Access Journals (Sweden)

    Yusuke Mori

    Full Text Available The centrosomal protein, CDK5RAP2, is a microcephaly protein that regulates centrosomal maturation by recruitment of a γ-tubulin ring complex (γ-TuRC onto centrosomes. In this report, we identified a novel human centrosomal protein, Cep169, as a binding partner of CDK5RAP2, a member of microtubule plus-end-tracking proteins (+TIPs. Cep169 interacts directly with CDK5RAP2 through CM1, an evolutionarily conserved domain, and colocalizes at the pericentriolar matrix (PCM around centrioles with CDK5RAP2. In addition, Cep169 interacts with EB1 through SxIP-motif responsible for EB1 binding, and colocalizes with CDK5RAP2 at the microtubule plus-end. EB1-binding-deficient Cep169 abolishes EB1 interaction and microtubule plus-end attachment, indicating Cep169 as a novel member of +TIPs. We further show that ectopic expression of either Cep169 or CDK5RAP2 induces microtubule bundling and acetylation in U2OS cells, and depletion of Cep169 induces microtubule depolymerization in HeLa cells, although Cep169 is not required for assembly of γ-tubulin onto centrosome by CDK5RAP2. These results show that Cep169 targets microtubule tips and regulates stability of microtubules with CDK5RAP2.

  6. The Cysteine Protease CEP1, a Key Executor Involved in Tapetal Programmed Cell Death, Regulates Pollen Development in Arabidopsis[W][OPEN

    Science.gov (United States)

    Zhang, Dandan; Liu, Di; Lv, Xiaomeng; Wang, Ying; Xun, Zhili; Liu, Zhixiong; Li, Fenglan; Lu, Hai

    2014-01-01

    Tapetal programmed cell death (PCD) is a prerequisite for pollen grain development in angiosperms, and cysteine proteases are the most ubiquitous hydrolases involved in plant PCD. We identified a papain-like cysteine protease, CEP1, which is involved in tapetal PCD and pollen development in Arabidopsis thaliana. CEP1 is expressed specifically in the tapetum from stages 5 to 11 of anther development. The CEP1 protein first appears as a proenzyme in precursor protease vesicles and is then transported to the vacuole and transformed into the mature enzyme before rupture of the vacuole. cep1 mutants exhibited aborted tapetal PCD and decreased pollen fertility with abnormal pollen exine. A transcriptomic analysis revealed that 872 genes showed significantly altered expression in the cep1 mutants, and most of them are important for tapetal cell wall organization, tapetal secretory structure formation, and pollen development. CEP1 overexpression caused premature tapetal PCD and pollen infertility. ELISA and quantitative RT-PCR analyses confirmed that the CEP1 expression level showed a strong relationship to the degree of tapetal PCD and pollen fertility. Our results reveal that CEP1 is a crucial executor during tapetal PCD and that proper CEP1 expression is necessary for timely degeneration of tapetal cells and functional pollen formation. PMID:25035401

  7. Talpid3-binding centrosomal protein Cep120 is required for centriole duplication and proliferation of cerebellar granule neuron progenitors.

    Directory of Open Access Journals (Sweden)

    Chuanqing Wu

    Full Text Available Granule neuron progenitors (GNPs are the most abundant neuronal type in the cerebellum. GNP proliferation and thus cerebellar development require Sonic hedgehog (Shh secreted from Purkinje cells. Shh signaling occurs in primary cilia originating from the mother centriole. Centrioles replicate only once during a typical cell cycle and are responsible for mitotic spindle assembly and organization. Recent studies have linked cilia function to cerebellar morphogenesis, but the role of centriole duplication in cerebellar development is not known. Here we show that centrosomal protein Cep120 is asymmetrically localized to the daughter centriole through its interaction with Talpid3 (Ta3, another centrosomal protein. Cep120 null mutant mice die in early gestation with abnormal heart looping. Inactivation of Cep120 in the central nervous system leads to both hydrocephalus, due to the loss of cilia on ependymal cells, and severe cerebellar hypoplasia, due to the failed proliferation of GNPs. The mutant GNPs lack Hedgehog pathway activity. Cell biological studies show that the loss of Cep120 results in failed centriole duplication and consequently ciliogenesis, which together underlie Cep120 mutant cerebellar hypoplasia. Thus, our study for the first time links a centrosomal protein necessary for centriole duplication to cerebellar morphogenesis.

  8. Comparação da ativação mioelétrica do glúteo máximo e bíceps femoral entre os agachamentos paralelo e com passada à frente Comparación de la activación mioeléctrica de los glúteos y bíceps femoral entre las sentadillas con los pies paralelos y los pies uno frente al otro Comparison of myoelectric activity of gluteus maximus and biceps femoris between parallel and lunge squat

    Directory of Open Access Journals (Sweden)

    Gustavo Leporace

    2012-09-01

    Full Text Available O objetivo desse estudo foi comparar a atividade mioelétrica (EMG do glúteo máximo e bíceps femoral entre o agachamento com passada à frente e com pés paralelos. Sete indivíduos realizaram oito repetições do agachamento paralelo (AP e com passada à frente (AF deslocando sobrecarga relativa a 50% da massa corporal. O EMG do glúteo máximo e bíceps femoral foi capturado, filtrado por um filtro passa-banda Butterworth de 4ª ordem (20-400 Hz e obtido valores RMS. Utilizou-se o teste de Wilcoxon para comparar o EMG normalizado entre os dois exercícios. Tanto o bíceps femoral (p = 0,041 quanto o glúteo máximo (p = 0,0059 apresentaram maior ativação no AF (30,9% para glúteo; 42,6% para bíceps em comparação ao AP (21,2% para glúteo; 24,7% para bíceps. Apesar da ativação moderada durante a execução dos exercícios, girando em torno de 25% a 45%, a resposta foi maior, para os participantes do estudo, no AF.El objetivo de este estudio fue comparar la actividad mioeléctrica (EMG del músculo glúteo mayor y el bíceps femoral entre la sentadilla con los pies uno frente al otro y los pies paralelos. Siete sujetos realizaron ocho repeticiones de la sentadilla paralela (AP y con los pies uno frente al otro (FA desplazando una masa igual a 50% del peso corporal. El EMG del músculo glúteo mayor y el bíceps femoral fueron capturados, filtrada por un filtro de banda de 4 º orden Butterworth (20-400 Hz y los valores RMS obtenidos. Se utilizó el test de Wilcoxon para comparar la EMG normalizada entre los dos ejercicios. Tanto el bíceps femoral (p = 0,041 y el glúteo mayor (p = 0,0059 mostraron una mayor activación en la FA (30,9% para lo glúteo y 52% para lo bíceps en comparación con el AP (21,2% para lo glúteo y 24,7% para lo bíceps. Aunque la activación moderada durante la ejecución de los ejercicios fue moderado, situándose en torno a un 25% a 45%, la respuesta fue mayor en el FA para los participantes del estudio

  9. Generating phase-matched high-order harmonics using CEP controlled few-cycle pulses

    International Nuclear Information System (INIS)

    Kovacs, K.; Tosa, V.; Dombi, P.; Porras, M.A.

    2010-01-01

    Complete text of publication follows. Recently Porras and Dombi showed, by performing analytical calculations, that it is possible to freeze or to control the variation of the carrier-to-envelope phase (CEP) of propagated few-cycle laser pulses in the focal region. These methods consist in changing the variation of the beam's spot size for different spectral components at the focusing element and/or placing a dispersive slab (or medium) in the way of the propagating pulse. We developed a numerical method to calculate the electric field of the laser in these special configurations, which allowed us to simulate high-order harmonic generation (HHG) and perform phase-matching (PM) calculations for different types of CEP variations of the input pulse. The fundamental pulse at 800 nm wavelength has a FWHM of 5 fs and peak intensity not exceeding 0.4 PW/cm 2 . HHG is assumed to take place in neon at low pressure (< 40 Torr) and the interaction medium is placed close to the focal region of the pulse. Under these conditions ionization rate remains low during HHG, thus in the PM calculations we do not take into account the dispersion due to plasma contribution and neutrals. We assume that the electric field is not perturbed during propagation and we perform PM calculations for different harmonic orders in the whole interaction region. We will present the effect of different CEP variations of the fundamental pulse on the high-harmonic spectra and will explore the possibilities to obtain strong coherent HH radiation under favorable PM conditions.

  10. Quantum-CEP processing spent ion exchange resins from nuclear power stations

    International Nuclear Information System (INIS)

    Kaczmarsky, Myron

    1997-01-01

    Quantum-CEP (Q-CEP) is an innovative and proprietary technology developed by Molten Metal Technology, Inc, which can process radioactive and mixed waste streams to decontaminate and recover resources of commercial value while achieving significant volume reduction and radionuclide stabilization. A Q-CEP facility, located in Oak Ridge, Tennessee, processes low-level radioactive spent ion exchange resins (IER) from U.S commercial nuclear power plants. The first campaign processing low level radioactive spent IER was successfully completed in December 1996. Other milestones, since December, include operating parallel Trains A and B simultaneously and processing 25,000 lb. dry resin (50,000 lb. wet resin) or six equivalent High Integrity Containers (HICs) in one batch campaign, in March; and processing 50,000 lb. dry resin or 12 equivalent HICs in one batch campaign in May. This paper presents results from the March campaign (97-008) in which 25,000 lb. of dry spent IER from five nuclear power stations were processed. This campaign has been selected since it is representative of campaigns completed during the first five months of operation. Key highlights for this campaign include processing six HICs in batch campaign while achieving a volume reduction of 24: 1. Key performance targets for the facility are to process an average of six HICs per campaign batch and achieve a volume reduction of 30: 1. The average batch size and other performance parameters have steadily improved during the initial operating period with radioactive resin. The progress was dramatically demonstrated by the May campaign during which 12 HICs were processed - achieving a volume reduction estimated to exceed 50: 1. The campaigns in March and May demonstrate that the facility's design and technology are capable of achieving and even exceeding the facility's key target performance parameters

  11. A truncating mutation in CEP55 is the likely cause of MARCH, a novel syndrome affecting neuronal mitosis.

    Science.gov (United States)

    Frosk, Patrick; Arts, Heleen H; Philippe, Julien; Gunn, Carter S; Brown, Emma L; Chodirker, Bernard; Simard, Louise; Majewski, Jacek; Fahiminiya, Somayyeh; Russell, Chad; Liu, Yangfan P; Hegele, Robert; Katsanis, Nicholas; Goerz, Conrad; Del Bigio, Marc R; Davis, Erica E

    2017-07-01

    Hydranencephaly is a congenital anomaly leading to replacement of the cerebral hemispheres with a fluid-filled cyst. The goals of this work are to describe a novel autosomal-recessive syndrome that includes hydranencephaly (multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia and hydranencephaly (MARCH)); to identify its genetic cause(s) and to provide functional insight into pathomechanism. We used homozygosity mapping and exome sequencing to identify recessive mutations in a single family with three affected fetuses. Immunohistochemistry, RT-PCR and imaging in cell lines, and zebrafish models, were used to explore the function of the gene and the effect of the mutation. We identified a homozygous nonsense mutation in CEP55 segregating with MARCH. Testing the effect of this allele on patient-derived cells indicated both a reduction of the overall CEP55 message and the production of a message that likely gives rise to a truncated protein. Suppression or ablation of cep55l in zebrafish embryos recapitulated key features of MARCH, most notably renal dysplasia, cerebellar hypoplasia and craniofacial abnormalities. These phenotypes could be rescued by full-length but not truncated human CEP55 message. Finally, we expressed the truncated form of CEP55 in human cells, where we observed a failure of truncated protein to localise to the midbody, leading to abscission failure and multinucleated daughter cells. CEP55 loss of function mutations likely underlie MARCH, a novel multiple congenital anomaly syndrome. This association expands the involvement of centrosomal proteins in human genetic disorders by highlighting a role in midbody function. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  12. Situando os comitês de ética em pesquisa: o sistema CEP (Brasil) em perspectiva

    OpenAIRE

    Fonseca, Claudia

    2015-01-01

    ResumoNeste artigo, apoiando-me num conjunto de obras recentes, pretendo fornecer subsídios para “situar” os comitês universitários de ética (CEPs) no Brasil dentro dum contexto político e acadêmico mais amplo. Primeiro, ao rever a narrativa de origem dos CEPs, situando o surgimento deles nos EUA dos anos 1950 e 1960, sugiro que esse modelo seja mais adequado à resolução de riscos legais da pesquisa científica do que à garantia mais abrangente do proceder ético. Em segundo lugar, evoco estilo...

  13. From disease modelling to personalised therapy in patients with CEP290 mutations [version 1; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    Elisa Molinari

    2017-05-01

    Full Text Available Mutations that give rise to premature termination codons are a common cause of inherited genetic diseases. When transcripts containing these changes are generated, they are usually rapidly removed by the cell through the process of nonsense-mediated decay. Here we discuss observed changes in transcripts of the centrosomal protein CEP290 resulting not from degradation, but from changes in exon usage. We also comment on a landmark paper (Drivas et al. Sci Transl Med. 2015 where modelling this process of exon usage may be used to predict disease severity in CEP290 ciliopathies, and how understanding this process may potentially be used for therapeutic benefit in the future.

  14. cep-1/p53-dependent dysplastic pathology of the aging C. elegans gonad.

    Science.gov (United States)

    McGee, Mathew D; Day, Nicholas; Graham, Jill; Melov, Simon

    2012-04-01

    The C. elegans germline and somatic gonad are actively developing until the animal reaches adulthood, and then continue to undergo striking changes as the animal ages. Reported changes include a depletion of available sperm, a decrease in oocyte quality up till mid-life, a reduction in germline nuclei, a decrease in fertility, and an accumulation of DNA in the midbody of aging C. elegans. Here, we have focused on the aging gonad in old animals, and show in detail that the aging gonad undergoes a massive uterine growth composed of endoreduplicating oocytes, yolk, and expanses of chromatin. We use a novel series of imaging techniques in combination with histological methodology for reconstructing aged worms in 3-dimensions, and show in old animals growing masses swelling inside the uterus to occupy most of the diameter of the worm. We link this accelerated growth to the cep-1/p53 tumor suppressor. Because cep-1 is required for DNA damage induced apoptosis, and daf-2 limits longevity, these results suggest a role for age-related DNA damage in dysplastic uterine growths, which in some respects resemble premalignant changes that can occur in aging mammals.

  15. G4CEP: A G4 theory modification by including pseudopotential for molecules containing first-, second- and third-row representative elements

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Cleuton de Souza [Instituto de Química, Universidade Estadual de Campinas, Barão Geraldo, P.O. Box 6154, 13083-970 Campinas, São Paulo (Brazil); Instituto de Ciências Exatas e Tecnologia, Universidade Federal do Amazonas, Campus de Itacoatiara, 69100-021 Itacoatiara, Amazonas (Brazil); Pereira, Douglas Henrique [Departamento de Ciências Exatas e Biotecnológicas, Universidade Federal do Tocantins, Campus de Gurupi, 77410-530 Gurupi, Tocantins (Brazil); Custodio, Rogério, E-mail: roger@iqm.unicamp.br [Instituto de Química, Universidade Estadual de Campinas, Barão Geraldo, P.O. Box 6154, 13083-970 Campinas, São Paulo (Brazil)

    2016-05-28

    The G4CEP composite method was developed from the respective G4 all-electron version by considering the implementation of compact effective pseudopotential (CEP). The G3/05 test set was used as reference to benchmark the adaptation by treating in this work atoms and compounds from the first and second periods of the periodic table, as well as representative elements of the third period, comprising 440 thermochemical data. G4CEP has not reached a so high level of accuracy as the G4 all-electron theory. G4CEP presented a mean absolute error around 1.09 kcal mol{sup −1}, while the original method presents a deviation corresponding to 0.83 kcal mol{sup −1}. The similarity of the optimized molecular geometries between G4 and G4CEP indicates that the core-electron effects and basis set adjustments may be pointed out as a significant factor responsible for the large discrepancies between the pseudopotential results and the experimental data, or even that the all-electron calculations are more efficient either in its formulation or in the cancellation of errors. When the G4CEP mean absolute error (1.09 kcal mol{sup −1}) is compared to 1.29 kcal mol{sup −1} from G3CEP, it does not seem so efficient. However, while the G3CEP uncertainty is ±4.06 kcal mol{sup −1}, the G4CEP deviation is ±2.72 kcal mol{sup −1}. Therefore, the G4CEP theory is considerably more reliable than any previous combination of composite theory and pseudopotential, particularly for enthalpies of formation and electron affinities.

  16. "Educational Regionalization" and the Gated Global: The Construction of the Caribbean Educational Policy Space

    Science.gov (United States)

    Jules, Tavis D.

    2015-01-01

    This article draws on "regime theory," particularly on the concepts of cooperation, compatibility of interests, and proclivity to compromise, to examine the rise of the Caribbean Educational Policy Space (CEPS). In making this argument, with the aid of a content analysis of 26 educational policies from the 15 member states of the…

  17. Analyzing alternative policy instruments for the irrigation sector : an assessment of the potential for water market development in the Chishtian Sub-division, Pakistan

    NARCIS (Netherlands)

    Strosser, P.

    1997-01-01


    The increasing scarcity of water and financial resources has made the economic dimension of water an important element of irrigation sector policies. Water pricing is the means traditionally used to incorporate economic issues into irrigation sector policies. More recently, water markets

  18. PHD1 links cell-cycle progression to oxygen sensing through hydroxylation of the centrosomal protein Cep192.

    Science.gov (United States)

    Moser, Sandra C; Bensaddek, Dalila; Ortmann, Brian; Maure, Jean-Francois; Mudie, Sharon; Blow, J Julian; Lamond, Angus I; Swedlow, Jason R; Rocha, Sonia

    2013-08-26

    PHD1 belongs to the family of prolyl-4-hydroxylases (PHDs) that is responsible for posttranslational modification of prolines on specific target proteins. Because PHD activity is sensitive to oxygen levels and certain byproducts of the tricarboxylic acid cycle, PHDs act as sensors of the cell's metabolic state. Here, we identify PHD1 as a critical molecular link between oxygen sensing and cell-cycle control. We show that PHD1 function is required for centrosome duplication and maturation through modification of the critical centrosome component Cep192. Importantly, PHD1 is also required for primary cilia formation. Cep192 is hydroxylated by PHD1 on proline residue 1717. This hydroxylation is required for binding of the E3 ubiquitin ligase SCF(Skp2), which ubiquitinates Cep192, targeting it for proteasomal degradation. By modulating Cep192 levels, PHD1 thereby affects the processes of centriole duplication and centrosome maturation and contributes to the regulation of cell-cycle progression. Copyright © 2013 The Authors. Published by Elsevier Inc. All rights reserved.

  19. The cep quorum-sensing system of Burkholderia cepacia H111 controls biofilm formation and swarming motility

    DEFF Research Database (Denmark)

    Huber, B.; Riedel, K.; Hentzer, Morten

    2001-01-01

    to rapidly colonize appropriate substrata. Evidence is provided that swarming motility of B. cepacia is quorum-sensing-regulated, possibly through the control of biosurfactant production. Complementation of the cepR mutant H111-R with different biosurfactants restored swarming motility while biofilm...

  20. High-pressure magnetic phase diagram of CeP studied by neutron diffraction

    International Nuclear Information System (INIS)

    Hannan, A.; Kohgi, M.; Iwasa, K.; Osakabe, T.

    2002-01-01

    Neutron-diffraction experiments have been performed in order to clarify the magnetic structures of CeP under pressures above 1.9 GPa using a sapphire-anvil cell. The P-T phase diagram up to 2.8 GPa has been investigated. Some new phases have been found, for example the phase 2 + (↑ ↑ ↓ ↓ ↑ ↑) under the pressure of 1.9 GPa. Type-IA antiferromagnetic structure (↑ ↑ ↓ ↓) was found below 22.5 and 45 K at 1.9 and 2.2 GPa, respectively. A phase characterized by the wave vector k=1/3 and a ferromagnetic phase were observed in the pressure range 2.5-2.8 GPa. (orig.)

  1. PENGEMBANGAN MODUL PEMBELAJARAN KIMIA BERVISI SETS BERORIENTASI CHEMO-ENTREPRENEURSHIP (CEP PADA MATERI LARUTAN ASAM BASA

    Directory of Open Access Journals (Sweden)

    M. Agus Prayitno

    2016-05-01

    Full Text Available Kimia merupakan salah satu mata pelajaran yang berkaitan dengan kehidupan sehari- hari, dari segi lingkungan teknologi, maupun masyarakat. Tujuan penelitian ini adalah menghasilkan modul pembelajaran kimia bervisi SETS berorientasi CEP pada materi larutan asam basa yang layak dan efektif digunakan dalam pembelajaran untuk meningkatkan motivasi belajar, minat wirausaha, dan hasil belajar siswa. Penelitian ini merupakan penelitian pengembangan. Uji coba kelayakan produk pada penelitian ini dilaksanakan di MA Mu’allimin Mu’allimat dengan model penelitian one group pre-test and post-test design dan di MAN Rembang dengan model penelitian pre-test and post-test control group design. Data penelitian diperoleh dengan metode validasi, observasi, dokumentasi, tes, dan skala Likert. Hasil validasi ahli materi, ahli media, dan praktisi menunjukkan bahwa modul pembelajaran kimia bervisi SETS berorientasi CEP sangat layak digunakan dalam pembelajaran kimia dengan skor ratarata pada aspek kegrafikan 95,00, aspek penyajian 95,33, aspek kebahasaan 95,00, dan aspek kegrafikan 94,44. Hasil uji coba modul di MA Mu’allimin Mu’allimat menunjukkan peningkatan motivasi 20%, minat wirausaha 25%, dan hasil belajar siswa 79%. Uji coba modul di MAN Rembang peningkatan motivasi belajar siswa, minat wirausaha, dan hasil belajar siswa kelas eksperimen sebesar 27%, 17% dan 66%, sedangkan peningkatan kelas kontrol secara berturutturut 0,4%, 11%, dan 24%.Chemistryis one of the subjects related to everyday life, in terms of environmental technology, and society. The purpose of this research is to produce visionary chemistry learning modules SETS with CEP oriented on acid-base materials which properly and effectively use in learning to improve learning motivation, entrepreneurial interest, and student learning outcomes. This research is development reaserch. Testing the product viability on the research carried out in MA Mu'allimin Mu'allimat with research model are one

  2. A sudden brightness decrease of the young pre-MS object GM Cep

    Science.gov (United States)

    Munari, U.; Castellani, F.; Giannini, T.; Antoniucci, S.; Lorenzetti, D.

    2017-11-01

    In the framework of our EXor monitoring programme dubbed EXORCISM (EXOR OptiCal and Infrared Systematic Monitoring - Antoniucci et al. 2013 PPVI, Lorenzetti et al. 2007 ApJ 665, 1182; Lorenzetti et al. 2009 ApJ 693, 1056), we observed a new fading of the optical brightness of the Young Stellar Object (YSO) GM Cep (d=870 pc). This is a well studied variable (Semkov & Peneva 2012 APSS,338,95; Ibryamov et al. 2015 PASA,32,11; Xiao, Kroll, & Henden 2010 AJ, 139, 1527; Sicilia-Aguilar et al. 2008 ApJ,673,382-3) whose light-curve is dominated by recurrent brightness dims, interpreted as non-periodical eclipse events due to orbiting dust structures that move along the line of sight (UXor-type variability - Grinin 1988).

  3. Transient analyzer

    International Nuclear Information System (INIS)

    Muir, M.D.

    1975-01-01

    The design and design philosophy of a high performance, extremely versatile transient analyzer is described. This sub-system was designed to be controlled through the data acquisition computer system which allows hands off operation. Thus it may be placed on the experiment side of the high voltage safety break between the experimental device and the control room. This analyzer provides control features which are extremely useful for data acquisition from PPPL diagnostics. These include dynamic sample rate changing, which may be intermixed with multiple post trigger operations with variable length blocks using normal, peak to peak or integrate modes. Included in the discussion are general remarks on the advantages of adding intelligence to transient analyzers, a detailed description of the characteristics of the PPPL transient analyzer, a description of the hardware, firmware, control language and operation of the PPPL transient analyzer, and general remarks on future trends in this type of instrumentation both at PPPL and in general

  4. Pharmacokinetics, pharmacodynamics and safety of CEP-26401, a high-affinity histamine-3 receptor antagonist, following single and multiple dosing in healthy subjects.

    Science.gov (United States)

    Spiegelstein, Ofer; Stevens, Jasper; Van Gerven, Joop; Nathan, Pradeep J; Maynard, James P; Mayleben, David W; Hellriegel, Edward; Yang, Ronghua

    2016-10-01

    CEP-26401 is a novel orally active, brain-penetrant, high-affinity histamine H3 receptor (H3R) antagonist, with potential therapeutic utility in cognition enhancement. Two randomized, double-blind, placebo-controlled dose escalation studies with single (0.02 to 5 mg) or multiple administration (0.02 to 0.5 mg once daily) of CEP-26401 were conducted in healthy subjects. Plasma and urine samples were collected to investigate CEP-26401 pharmacokinetics. Pharmacodynamic endpoints included a subset of tasks from the Cambridge Neuropsychological Test Automated Battery (CANTAB) and nocturnal polysomnography. Population pharmacokinetic-pharmacodynamic modeling was conducted on one CANTAB and one polysomnography parameter of interest. CEP-26401 was slowly absorbed (median tmax range 3-6 hours) and the mean terminal elimination half-life ranged from 24-60 hours. Steady-state plasma concentrations were achieved within six days of dosing. CEP-26401 exhibits dose- and time-independent pharmacokinetics, and renal excretion is a major elimination pathway. CEP-26401 had a dose-dependent negative effect on sleep, with some positive effects on certain CANTAB cognitive parameters seen at lower concentrations. The derived three compartment population pharmacokinetic model, with first-order absorption and elimination, accurately described the available pharmacokinetic data. CEP-26401 was generally well tolerated up to 0.5 mg/day with most common treatment related adverse events being headache and insomnia. Further clinical studies are required to establish the potential of low-dose CEP-26401 in cognition enhancement. © The Author(s) 2016.

  5. Determination of electron temperature of the envelopes for the A2 Ia supergiants α Cyg and ν Cep

    International Nuclear Information System (INIS)

    Glushneva, I.N.

    1984-01-01

    On the basis of the analysis of the energy distribution data in the spectra of two bright A2 Ia supergiants, α Cyg and ω Cep, the electron temperature of the envelope and the contributions of the star and of the mantle in the continuum formation are determined. It is shown that the temperature obtained on the basis of the observations in the ultraviolet range lambda lambda 3200-3600 A is slightly higher that the effective temperature (Tsub(e) approximately 8500 K), being 12500 K in the case of α Cyg and 11000 K for ν Cep. The analysis of the α Cyg infrared excess shows that the regions with T approximately 10 4 K as well as with higher temperatures (about 2x10 4 K) exist in the envelope

  6. Eletromiografia do bíceps braquial em contrações dinâmicas

    Directory of Open Access Journals (Sweden)

    Lucenildo Silva Cerqueira

    2013-12-01

    Full Text Available INTRODUÇÃO: A reprodutibilidade da atividade eletromiográfica de superfície (EMG é mais estudada em protocolos que envolvem contrações isométricas. Alguns fatores relacionados às contrações dinâmicas podem contribuir para a instabilidade do sinal mioelétrico e dificultar a reprodutibilidade da medida da EMG. OBJETIVO: Determinar a reprodutibilidade teste-reteste e quantificar o erro técnico da medida da frequência mediana (FM e da amplitude (root mean square, RMS da EMG, em contrações dinâmicas e estáticas. MÉTODOS: Dez sujeitos foram testados em dois dias, sendo a atividade EMG registrada na maior porção do bíceps braquial. No primeiro dia foi feito o teste de uma repetição máxima (1RM e de contração voluntária máxima (CVM. No segundo dia foram realizadas duas séries de 10 contrações dos flexores do cotovelo com 75% de 1RM, entremeadas por 1 h em repouso. Antes de cada série foi realizada uma CVM. RESULTADOS: Para a FM e RMS foi observado alto coeficiente de correlação intraclasse para o sinal do bíceps braquial (CCI = 0,90-0,98 para a FM; CCI = 0,89-0,94 para o RMS e de baixo para moderado coeficiente de variação (CV = 2,5-6,2% para a FM; CV = 14,6-16,3% para o RMS em ambos os testes. Não foi observada diferença significativa entre teste e reteste (p > 0,05. CONCLUSÃO: A FM e o RMS apresentam alta confiabilidade e baixo a moderado erro em contrações estáticas e dinâmicas, possibilitando o uso da EMG para investigação da fadiga e de desordens neuromusculares.

  7. Transcription factors CEP-1/p53 and CEH-23 collaborate with AAK-2/AMPK to modulate longevity in Caenorhabditis elegans.

    Science.gov (United States)

    Chang, Hsin-Wen; Pisano, Steve; Chaturbedi, Amaresh; Chen, Jennifer; Gordon, Sarah; Baruah, Aiswarya; Lee, Siu Sylvia

    2017-08-01

    A decline in mitochondrial electron transport chain (ETC) function has long been implicated in aging and various diseases. Recently, moderate mitochondrial ETC dysfunction has been found to prolong lifespan in diverse organisms, suggesting a conserved and complex role of mitochondria in longevity determination. Several nuclear transcription factors have been demonstrated to mediate the lifespan extension effect associated with partial impairment of the ETC, suggesting that compensatory transcriptional response to be crucial. In this study, we showed that the transcription factors CEP-1/p53 and CEH-23 act through a similar mechanism to modulate longevity in response to defective ETC in Caenorhabditis elegans. Genomewide gene expression profiling comparison revealed a new link between these two transcription factors and AAK-2/AMP kinase (AMPK) signaling. Further functional analyses suggested that CEP-1/p53 and CEH-23 act downstream of AAK-2/AMPK signaling and CRTC-1 transcriptional coactivator to promote stress resistance and lifespan. As AAK-2, CEP-1, and CEH-23 are all highly conserved, our findings likely provide important insights for understanding the organismal adaptive response to mitochondrial dysfunction in diverse organisms and will be relevant to aging and pathologies with a mitochondrial etiology in human. © 2017 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.

  8. An anomalous extinction law in the Cep OB3b young cluster: Evidence for dust processing during gas dispersal

    International Nuclear Information System (INIS)

    Allen, Thomas S.; Prchlik, Jakub J.; Megeath, S. Thomas; Gutermuth, Robert A.; Pipher, Judith L.; Naylor, Tim; Jeffries, R. D.

    2014-01-01

    We determine the extinction law through Cep OB3b, a young cluster of 3000 stars undergoing gas dispersal. The extinction is measured toward 76 background K giants identified with MMT/Hectospec spectra. Color excess ratios were determined toward each of the giants using V and R photometry from the literature, g, r, i, and z photometry from the Sloan Digital Sky Survey and J, H, and K s photometry from the Two Micron All Sky Survey. These color excess ratios were then used to construct the extinction law through the dusty material associated with Cep OB3b. The extinction law through Cep OB3b is intermediate between the R V = 3.1 and R V = 5 laws commonly used for the diffuse atomic interstellar medium and dense molecular clouds, respectively. The dependence of the extinction law on line-of-sight A V is investigated and we find the extinction law becomes shallower for regions with A V > 2.5 mag. We speculate that the intermediate dust law results from dust processing during the dispersal of the molecular cloud by the cluster.

  9. An anomalous extinction law in the Cep OB3b young cluster: Evidence for dust processing during gas dispersal

    Energy Technology Data Exchange (ETDEWEB)

    Allen, Thomas S.; Prchlik, Jakub J.; Megeath, S. Thomas [University of Toledo, Ritter Astrophysical Observatory, Department of Physics and Astronomy, Toledo, OH 43606 (United States); Gutermuth, Robert A. [Five College Astronomy Department, Smith College, Northampton, MA 01063 (United States); Pipher, Judith L. [Department of Physics and Astronomy, University of Rochester, Rochester, NY 14627 (United States); Naylor, Tim [School of Physics, University of Exeter, Exeter, UK EX4 4QL (United Kingdom); Jeffries, R. D. [Astrophysics Group, School of Physical and Geographical Sciences, Keele University, Keele, Staffordshire, UK ST5 5BG (United Kingdom)

    2014-05-10

    We determine the extinction law through Cep OB3b, a young cluster of 3000 stars undergoing gas dispersal. The extinction is measured toward 76 background K giants identified with MMT/Hectospec spectra. Color excess ratios were determined toward each of the giants using V and R photometry from the literature, g, r, i, and z photometry from the Sloan Digital Sky Survey and J, H, and K{sub s} photometry from the Two Micron All Sky Survey. These color excess ratios were then used to construct the extinction law through the dusty material associated with Cep OB3b. The extinction law through Cep OB3b is intermediate between the R{sub V} = 3.1 and R{sub V} = 5 laws commonly used for the diffuse atomic interstellar medium and dense molecular clouds, respectively. The dependence of the extinction law on line-of-sight A{sub V} is investigated and we find the extinction law becomes shallower for regions with A{sub V} > 2.5 mag. We speculate that the intermediate dust law results from dust processing during the dispersal of the molecular cloud by the cluster.

  10. Combining Cloud-based Workflow Management System with SOA and CEP to Create Agility in Collaborative Environment

    Directory of Open Access Journals (Sweden)

    Marian STOICA

    2017-01-01

    Full Text Available In current economy, technological solutions like cloud computing, service-oriented architecture (SOA and complex event processing (CEP are recognized as modern approaches used for increasing the business agility and achieving innovation. The complexity of collaborative business environment raises more and more the need for performant workflow management systems (WfMS that meet current requirements. Each approach has advantages, but also faces challenges. In this paper we propose a solution for integration of cloud computing with WfMS, SOA and CEP that allows these technologies to complete each other and bank on their benefits to increase agility and reduce the challenges/problems. The paper presents a short introduction in the subject, followed by an analysis of the combination between cloud computing and WfMS and the benefits of cloud based workflow management system. The paper ends with a solution for combining cloud WfMS with SOA and CEP in order to gain business agility and real time collaboration, followed by conclusions and research directions.

  11. Stabilization of Cartwheel-less Centrioles for Duplication Requires CEP295-Mediated Centriole-to-Centrosome Conversion

    Directory of Open Access Journals (Sweden)

    Denisse Izquierdo

    2014-08-01

    Full Text Available Vertebrate centrioles lose their geometric scaffold, the cartwheel, during mitosis, concurrently with gaining the ability to recruit the pericentriolar material (PCM and thereby function as the centrosome. Cartwheel removal has recently been implicated in centriole duplication, but whether “cartwheel-less” centrioles are intrinsically stable or must be maintained through other modifications remains unclear. Here, we identify a newborn centriole-enriched protein, KIAA1731/CEP295, specifically mediating centriole-to-centrosome conversion but dispensable for cartwheel removal. In the absence of CEP295, centrioles form in the S/G2 phase and lose their associated cartwheel in mitosis but cannot be converted to centrosomes, uncoupling the two events. Strikingly, centrioles devoid of both the PCM and the cartwheel progressively lose centriolar components, whereas centrioles associating with either the cartwheel or PCM alone can exist stably. Thus, cartwheel removal can have grave repercussions to centriole stability, and centriole-to-centrosome conversion mediated by CEP295 must occur in parallel to maintain cartwheel-less centrioles for duplication.

  12. Contribuições do cep para a melhoria do desempenho do pós-vendas na indústria calçadista

    Directory of Open Access Journals (Sweden)

    Paulo Emílio Mülle

    2015-04-01

    Full Text Available Este artigo apresenta os resultados de uma pesquisa que teve por finalidade avaliar as contribuições do Controle Estaístico de Processos - CEP para melhoria do desempenho do pós-vendas na indústria calçadista do Vale do Paranhana, no Brasil. O estudo foi focado nas etapas do processo de colagem, sendo atualmente o principal problema do setor produtivo, através de um acompanhamento mensal sobre os índices de devoluções e através de registros de pós-vendas sobre tal problema. O estudo foi realizado com base em análises qualitativas, quantitativas e na aplicação do CEP. A partir de relatórios da empresa, os dados foram analisados em cartas de controle estatístico de processos por atributos, diagrama de Pareto e histograma para melhorar a operação crítica do setor produtivo investigado. Após a aplicação da técnica, os principais resultados dessa pesquisa proporcionaram a melhoria de processo de controle da qualidade, uma vez que foi implantando um novo sistema de acompanhamento nas operações do processo e seus responsáveis, melhorando assim o desempenho dos indicadores de pós-vendas da empresa, devido à redução de defeitos de qualidade encontrados pelos clientes. This paper presents the results of a study that aimed to assess the contributions of the statistical process control - SPC to improve the post-sales performance in the footwear industry Paranhana Valley in Brazil. The study focused on the steps of the bonding process, currently being the main problem of the productive sector, through a monthly monitoring of rates of returns and through post- sales records on this issue. The study was based on qualitative, quantitative and application of SPC analysis. From company reports, data were analyzed in letters of statistical process control by attributes, Pareto diagram and histogram to improve the critical operation of the productive sector investigated. After application of the technique, the main results of this

  13. Metal and physico-chemical variations at a hydroelectric reservoir analyzed by Multivariate Analyses and Artificial Neural Networks: environmental management and policy/decision-making tools.

    Science.gov (United States)

    Cavalcante, Y L; Hauser-Davis, R A; Saraiva, A C F; Brandão, I L S; Oliveira, T F; Silveira, A M

    2013-01-01

    This paper compared and evaluated seasonal variations in physico-chemical parameters and metals at a hydroelectric power station reservoir by applying Multivariate Analyses and Artificial Neural Networks (ANN) statistical techniques. A Factor Analysis was used to reduce the number of variables: the first factor was composed of elements Ca, K, Mg and Na, and the second by Chemical Oxygen Demand. The ANN showed 100% correct classifications in training and validation samples. Physico-chemical analyses showed that water pH values were not statistically different between the dry and rainy seasons, while temperature, conductivity, alkalinity, ammonia and DO were higher in the dry period. TSS, hardness and COD, on the other hand, were higher during the rainy season. The statistical analyses showed that Ca, K, Mg and Na are directly connected to the Chemical Oxygen Demand, which indicates a possibility of their input into the reservoir system by domestic sewage and agricultural run-offs. These statistical applications, thus, are also relevant in cases of environmental management and policy decision-making processes, to identify which factors should be further studied and/or modified to recover degraded or contaminated water bodies. Copyright © 2012 Elsevier B.V. All rights reserved.

  14. The test about blood serum capabilities in maintaining the quality of bull spermatozoa during storage in cep diluent at refrigerator temperature

    Science.gov (United States)

    Ducha, Nur

    2018-03-01

    The storage of spermatozoa requires a protective material from cold shock events and the presence of free radicals.In CEP diluent contain BSA, that was used as spermatozoa protection. This study aim was to examine the ability of cow blood serum in replacing BSA as spermatozoa protective in CEP diluent. Fresh semen from Limousin bull was diluted with CEP diluent + BSA as control, in the treatment group were CEP without BSA, but replaced with 3%, 5%, and 7% serum from fresh blood. Spermatozoa quality tests included motility and viability. The motility of spermatozoa was observed by two people using a light microscope with 200 X magnification at temperature of 37°C. The method of viability observation was eosin nigrosin staining, and observed under a light microscope with 400 X magnification. The results showed that the replacement of cow blood serum with various concentrations gave different effects on the quality of spermatozoa. The best motility and viability of the treatment group was at serum concentrations of 5% after eight days storage and was not significantly different from the controls. The conclusion in this study was cow blood serum can replace BSA in CEP diluents.

  15. Using Complex Event Processing (CEP) and vocal synthesis techniques to improve comprehension of sonified human-centric data

    Science.gov (United States)

    Rimland, Jeff; Ballora, Mark

    2014-05-01

    The field of sonification, which uses auditory presentation of data to replace or augment visualization techniques, is gaining popularity and acceptance for analysis of "big data" and for assisting analysts who are unable to utilize traditional visual approaches due to either: 1) visual overload caused by existing displays; 2) concurrent need to perform critical visually intensive tasks (e.g. operating a vehicle or performing a medical procedure); or 3) visual impairment due to either temporary environmental factors (e.g. dense smoke) or biological causes. Sonification tools typically map data values to sound attributes such as pitch, volume, and localization to enable them to be interpreted via human listening. In more complex problems, the challenge is in creating multi-dimensional sonifications that are both compelling and listenable, and that have enough discrete features that can be modulated in ways that allow meaningful discrimination by a listener. We propose a solution to this problem that incorporates Complex Event Processing (CEP) with speech synthesis. Some of the more promising sonifications to date use speech synthesis, which is an "instrument" that is amenable to extended listening, and can also provide a great deal of subtle nuance. These vocal nuances, which can represent a nearly limitless number of expressive meanings (via a combination of pitch, inflection, volume, and other acoustic factors), are the basis of our daily communications, and thus have the potential to engage the innate human understanding of these sounds. Additionally, recent advances in CEP have facilitated the extraction of multi-level hierarchies of information, which is necessary to bridge the gap between raw data and this type of vocal synthesis. We therefore propose that CEP-enabled sonifications based on the sound of human utterances could be considered the next logical step in human-centric "big data" compression and transmission.

  16. G3(MP2)-CEP theory and applications for compounds containing atoms from representative first, second and third row elements of the periodic table.

    Science.gov (United States)

    Pereira, Douglas Henrique; Rocha, Carlos Murilo Romero; Morgon, Nelson Henrique; Custodio, Rogério

    2015-08-01

    The compact effective potential (CEP) pseudopotential was adapted to the G3(MP2) theory, herein referred to as G3(MP2)-CEP, and applied to the calculation of enthalpies of formation, ionization energies, atomization energies, and electron and proton affinities for 446 species containing elements of the 1st, 2nd, and 3rd rows of the periodic table. A total mean absolute deviation of 1.67 kcal mol(-1) was achieved with G3(MP2)-CEP, compared with 1.47 kcal mol(-1) for G3(MP2). Electron affinities and enthalpies of formation are the properties exhibiting the lowest deviations with respect to the original G3(MP2) theory. The use of pseudopotentials and composite theories in the framework of the G3 theory is feasible and compatible with the all electron approach. Graphical Abstract Application of composite methods in high-level ab initio calculations.

  17. The Discovery of Carboxyethylpyrroles (CEPs): Critical Insights into AMD, Autism, Cancer, and Wound Healing from Basic Research on the Chemistry of Oxidized Phospholipids

    Science.gov (United States)

    Salomon, Robert G.; Hong, Li; Hollyfield, Joe G.

    2011-01-01

    Basic research, exploring the hypothesis that 2-(ω-carboxyethyl)pyrrole (CEP) modifications of proteins are generated nonenzymatically in vivo is delivering a bonanza of molecular mechanistic insights into age-related macular degeneration, autism, cancer, and wound healing. CEPs are produced through covalent modification of protein lysyl ε-amino groups by γ-hydroxyalkenal phospholipids that are formed by oxidative cleavage of docosahexaenate-containing phospholipids. Chemical synthesis of CEP-modified proteins and the production of highly specific antibodies that recognize them preceded and facilitated their detection in vivo and enabled exploration of their biological occurrence and activities. This investigational approach –from the chemistry of biomolecules to disease phenotype – is proving to be remarkably productive. PMID:21875030

  18. CEP128 Localizes to the Subdistal Appendages of the Mother Centriole and Regulates TGF-β/BMP Signaling at the Primary Cilium

    DEFF Research Database (Denmark)

    Mönnich, Maren; Borgeskov, Louise; Breslin, Loretta

    2018-01-01

    The centrosome is the main microtubule-organizing center in animal cells and comprises a mother and daughter centriole surrounded by pericentriolar material. During formation of primary cilia, the mother centriole transforms into a basal body that templates the ciliary axoneme. Ciliogenesis depends...... on mother centriole-specific distal appendages, whereas the role of subdistal appendages in ciliary function is unclear. Here, we identify CEP128 as a centriole subdistal appendage protein required for regulating ciliary signaling. Loss of CEP128 did not grossly affect centrosomal or ciliary structure...

  19. The policies

    International Nuclear Information System (INIS)

    Laruelle, Ph.; Snegaroff, Th.; Moreau, S.; Tellenne, C.; Brunel, S.

    2005-01-01

    Fourth chapter of the book on the geo-policy of the sustainable development, this chapter deal with the different and international policies concerned by the problem. The authors analyze the american energy attitude and policy, the economical equilibrium facing the environmental equilibrium for the european policy, the sanctified and sacrificed nature and the japanese attitude, India and China, the great fear of the 21 century and the sustainable development in Africa. (A.L.B.)

  20. p38- and MK2-dependent signalling promotes stress-induced centriolar satellite remodelling via 14-3-3-dependent sequestration of CEP131/AZI1

    DEFF Research Database (Denmark)

    Tollenaere, Maxim A X; Villumsen, Bine H; Blasius, Melanie

    2015-01-01

    Centriolar satellites (CS) are small granular structures that cluster in the vicinity of centrosomes. CS are highly susceptible to stress stimuli, triggering abrupt displacement of key CS factors. Here we discover a linear p38-MK2-14-3-3 signalling pathway that specifically targets CEP131 to trig...

  1. Conserving analyst attention units: use of multi-agent software and CEP methods to assist information analysis

    Science.gov (United States)

    Rimland, Jeffrey; McNeese, Michael; Hall, David

    2013-05-01

    Although the capability of computer-based artificial intelligence techniques for decision-making and situational awareness has seen notable improvement over the last several decades, the current state-of-the-art still falls short of creating computer systems capable of autonomously making complex decisions and judgments in many domains where data is nuanced and accountability is high. However, there is a great deal of potential for hybrid systems in which software applications augment human capabilities by focusing the analyst's attention to relevant information elements based on both a priori knowledge of the analyst's goals and the processing/correlation of a series of data streams too numerous and heterogeneous for the analyst to digest without assistance. Researchers at Penn State University are exploring ways in which an information framework influenced by Klein's (Recognition Primed Decision) RPD model, Endsley's model of situational awareness, and the Joint Directors of Laboratories (JDL) data fusion process model can be implemented through a novel combination of Complex Event Processing (CEP) and Multi-Agent Software (MAS). Though originally designed for stock market and financial applications, the high performance data-driven nature of CEP techniques provide a natural compliment to the proven capabilities of MAS systems for modeling naturalistic decision-making, performing process adjudication, and optimizing networked processing and cognition via the use of "mobile agents." This paper addresses the challenges and opportunities of such a framework for augmenting human observational capability as well as enabling the ability to perform collaborative context-aware reasoning in both human teams and hybrid human / software agent teams.

  2. Casting epPCR (cepPCR): A simple random mutagenesis method to generate high quality mutant libraries.

    Science.gov (United States)

    Yang, Jianhua; Ruff, Anna J; Arlt, Marcus; Schwaneberg, Ulrich

    2017-09-01

    During the last decade, directed evolution has become a standard protein engineering strategy to reengineer proteins for industrial applications under high stress conditions (e.g., high temperature, extreme pH, ionic liquids, or organic solvents). The most commonly employed method for diversity generation to improve biocatalysts for these properties is random mutagenesis by error-prone polymerase chain reaction (epPCR). However, recent reports show that epPCR often fails to produce >70% of beneficial positions/amino acid exchanges which improve enzyme properties such as organic solvent or ionic liquid resistance. In this report, bsla (543 bp, small lipase gene from Bacillus subtilis) was divided into three fragments (147, 192, 204 bp). Each fragment was subjected to an epPCR with a high mutation load (22, 31, and 33 mutations per kb) in order to increase the number of identified beneficial positions while maintaining a fraction of active population which can efficiently be screened in agar plate or microtiter plate format. The use of this "casting epPCR" process termed as (cepPCR), doubles the number of identified beneficial positions (from 14% to 29%), when compared to standard epPCR for the BSLA enzyme model. A further increase to 39% of beneficial positions is obtainable through combination of cepPCR with the transversion biased sequence saturation mutagenesis (SeSaM) method. Furthermore, sequencing of up to 600 mutations per fragment provided valuable insights into the correlation of total throughput and number of identified beneficial positions as well as how an efficient balance of screening efforts to obtainable results can be achieved in directed evolution campaigns. Biotechnol. Bioeng. 2017;114: 1921-1927. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

  3. Copy number variation in CEP57L1 predisposes to congenital absence of bilateral ACL and PCL ligaments.

    Science.gov (United States)

    Liu, Yichuan; Li, Yun; March, Michael E; Nguyen, Kenny; Kenny, Nguyen; Xu, Kexiang; Wang, Fengxiang; Guo, Yiran; Keating, Brendan; Glessner, Joseph; Li, Jiankang; Ganley, Theodore J; Zhang, Jianguo; Deardorff, Matthew A; Xu, Xun; Hakonarson, Hakon

    2015-11-11

    Absence of the anterior (ACL) or posterior cruciate ligament (PCL) are rare congenital malformations that result in knee joint instability, with a prevalence of 1.7 per 100,000 live births and can be associated with other lower-limb abnormalities such as ACL agnesia and absence of the menisci of the knee. While a few cases of absence of ACL/PCL are reported in the literature, a number of large familial case series of related conditions such as ACL agnesia suggest a potential underlying monogenic etiology. We performed whole exome sequencing of a family with two individuals affected by ACL/PCL. We identified copy number variation (CNV) deletion impacting the exon sequences of CEP57L1, present in the affected mother and her affected daughter based on the exome sequencing data. The deletion was validated using quantitative PCR (qPCR), and the gene was confirmed to be expressed in ACL ligament tissue. Interestingly, we detected reduced expression of CEP57L1 in Epstein-Barr virus (EBV) cells from the two patients in comparison with healthy controls. Evaluation of 3D protein structure showed that the helix-binding sites of the protein remain intact with the deletion, but other functional binding sites related to microtubule attachment are missing. The specificity of the CNV deletion was confirmed by showing that it was absent in ~700 exome sequencing samples as well as in the database of genomic variations (DGV), a database containing large numbers of annotated CNVs from previous scientific reports. We identified a novel CNV deletion that was inherited through an autosomal dominant transmission from an affected mother to her affected daughter, both of whom suffered from the absence of the anterior and posterior cruciate ligaments of the knees.

  4. "High" Achievers? Cannabis Access and Student Performance. CEP Discussion Paper No. 1340

    Science.gov (United States)

    Marie, Olivier; Zölitz, Ulf

    2015-01-01

    This paper investigates how legal cannabis access affects student performance. Identification comes from an exceptional policy introduced in the city of Maastricht which discriminated legal access based on individuals' nationality. We apply a difference-in-difference approach using administrative panel data on over 54,000 course grades of local…

  5. 53 W average power CEP-stabilized OPCPA system delivering 5.5 TW few cycle pulses at 1 kHz repetition rate.

    Science.gov (United States)

    Budriūnas, Rimantas; Stanislauskas, Tomas; Adamonis, Jonas; Aleknavičius, Aidas; Veitas, Gediminas; Gadonas, Darius; Balickas, Stanislovas; Michailovas, Andrejus; Varanavičius, Arūnas

    2017-03-06

    We present a high peak and average power optical parametric chirped pulse amplification system driven by diode-pumped Yb:KGW and Nd:YAG lasers running at 1 kHz repetition rate. The advanced architecture of the system allows us to achieve >53 W average power combined with 5.5 TW peak power, along with sub-220 mrad CEP stability and sub-9 fs pulse duration at a center wavelength around 880 nm. Broadband, background-free, passively CEP stabilized seed pulses are produced in a series of cascaded optical parametric amplifiers pumped by the Yb:KGW laser, while a diode-pumped Nd:YAG laser system provides multi-mJ pump pulses for power amplification stages. Excellent stability of output parameters over 16 hours of continuous operation is demonstrated.

  6. DISPOSICIÓN SAGITAL DEL RAQUIS LUMBAR Y TORÁCICO EN EL EJERCICIO DE CURL DE BÍCEPS CON BARRA DE BIPEDESTACIÓN

    Directory of Open Access Journals (Sweden)

    Pedro Ángel López Miñarro

    2007-01-01

    Full Text Available La disposición sagital del raquis torácico y lumbar fue valorada mediante un inclinómetro Unilevel (ISOMED en 40 usuarios de salas de musculación privadas (media de edad: 24,6 ± 5,6 años en bipedestación habitual y al realizar el ejercicio del curl de bíceps con barra. En este ejercicio, la lordosis lumbar fue valorada al final de la fase concéntrica de la 6ª repetición, mientras que la cifosis torácica fue valorada al final de la fase excéntrica de la 8ª repetición, en la primera y segunda series. Los valores medios de cifosis dorsal en bipedestación y en el curl de bíceps con barra fueron de 46,00º ± 9,50º y 48,25º ± 9,80º, respectivamente (p>0,05. Respecto a la lordosis lumbar, los valores medios fueron de 30,52º ± 7,93º y 37,52º ± 9,32º, respectivamente (p<0,001. Al clasificar los valores angulares en base a las referencias de normalidad, se observa un mayor porcentaje de posturas hiperlordóticas al realizar el curl de bíceps (45% respecto a la bipedestación habitual (10%. En conclusión, al realizar el ejercicio del curl de bíceps con barra se observa un mayor ángulo de lordosis lumbar, que aumenta la frecuencia de posturas hiperlordóticas al final de la fase concéntrica del ejercicio. Es preciso enseñar a los usuarios a mantener una disposición alineada del raquis lumbar y torácico cuando realicen el ejercicio.

  7. VizieR Online Data Catalog: Extinction law in the Cep OB3b young cluster (Allen+, 2014)

    Science.gov (United States)

    Allen, T. S.; Prchlik, J. J.; Megeath, S. T.; Gutermuth, R. A.; Pipher, J. L.; Naylor, T.; Jeffries, R. D.

    2017-06-01

    We use Johnson V and Cousins Rc (hereafter called VR) band phot from the Isaac Newton Telescope (INT), compiled in the catalog of Littlefair et al. (2010, J/MNRAS/403/545). The R-band photometry was obtained using the Sloan r filter. It was calibrated against photometric standard stars measured in the Cousins Rc filter with an arbitrary zero point. Moderate resolution ((λ/Δλ)~1000-2000, FWHM resolution of about 6 Å) optical spectra (covering 4000-9000 Å) were obtained for ~1700 sources toward Cep OB3b using the multi-fiber spectrograph Hectospec on the MMT telescope. About 600 sources were selected for observation because they were determined to be possible cluster members (Allen et al. 2012, J/ApJ/750/125), based on indicators of youth, such as IR emission due to circumstellar dusty material and heightened X-ray activity. We use an extinction map from Allen et al. (2012, J/ApJ/750/125) to initially estimate the extinction toward each source. This map is derived using the 2MASS Point Source Catalog (Skrutskie et al. 2006AJ....131.1163S, Cat. VII/233) H and Ks band photometry of background stars. (1 data file).

  8. The 'WN + WC' Wolf-Rayet stars MR 111 and GP CEP - Spectrum binaries or missing links?

    Science.gov (United States)

    Massey, Philip; Grove, Kjirsten

    1989-09-01

    MR 111 and GP Cep are two Wolf-Rayet stars classified as 'WN + WC', showing emission features of both the nitrogen and carbon sequences. They are also both known spectroscopic binaries, providing an excellent opportunity to determine whether the WN and WC features arise in two stars or in a single 'transition' object whose composition is intermediate between that of WN and WC stars. A radial velocity study of the C IV 5806A and N IV 7107A lines shows that these two lines vary in phase, and that therefore both sets of emission lines are produced in a single object in each of these two systems. In addition, an orbit solution is given for MR 111. If the mass of the W-R star is like that known in other binary systems, then the mass of the as-yet undetected companion is at least 15 solar masses, consistent with that of other W-R binaries. The mass of companion must be greater than that of the W-R component, unless the W-R star is very massive (m greater than 40 solar masses).

  9. Evaluation and implementation of CEP mechanisms to act upon infrastructure metrics monitored by Ganglia

    CERN Document Server

    Adam, Martin

    2015-01-01

    The LHC experiments are progressively moving towards computing resources that are provided dynamically by Cloud services. It is important to monitor the health and performance of the virtual machines of these dynamic clusters and to provide early warnings in order to prevent the problems of degraded service and interruptions due to eventual failures of the cluster nodes. The goal of the project is to develop a system that will digest monitoring information coming from the cluster, analyze it almost in real time and provide necessary input for the control engine of the workload management systems of the experiments. The system should be generic and not coupled to any experiment frameworks, so that it can be used by any LHC experiment.

  10. The stream of experience when watching artistic movies. Dynamic aesthetic effects revealed by the Continuous Evaluation Procedure (CEP).

    Science.gov (United States)

    Muth, Claudia; Raab, Marius H; Carbon, Claus-Christian

    2015-01-01

    Research in perception and appreciation is often focused on snapshots, stills of experience. Static approaches allow for multidimensional assessment, but are unable to catch the crucial dynamics of affective and perceptual processes; for instance, aesthetic phenomena such as the "Aesthetic-Aha" (the increase in liking after the sudden detection of Gestalt), effects of expectation, or Berlyne's idea that "disorientation" with a "promise of success" elicits interest. We conducted empirical studies on indeterminate artistic movies depicting the evolution and metamorphosis of Gestalt and investigated (i) the effects of sudden perceptual insights on liking; that is, "Aesthetic Aha"-effects, (ii) the dynamics of interest before moments of insight, and (iii) the dynamics of complexity before and after moments of insight. Via the so-called Continuous Evaluation Procedure (CEP) enabling analogous evaluation in a continuous way, participants assessed the material on two aesthetic dimensions blockwise either in a gallery or a laboratory. The material's inherent dynamics were described via assessments of liking, interest, determinacy, and surprise along with a computational analysis on the variable complexity. We identified moments of insight as peaks in determinacy and surprise. Statistically significant changes in liking and interest demonstrated that: (i) insights increase liking, (ii) interest already increases 1500 ms before such moments of insight, supporting the idea that it is evoked by an expectation of understanding, and (iii) insights occur during increasing complexity. We propose a preliminary model of dynamics in liking and interest with regard to complexity and perceptual insight and discuss descriptions of participants' experiences of insight. Our results point to the importance of systematic analyses of dynamics in art perception and appreciation.

  11. The stream of experience when watching artistic movies. Dynamic aesthetic effects revealed by the continuous evaluation procedure (CEP

    Directory of Open Access Journals (Sweden)

    Claudia eMuth

    2015-03-01

    Full Text Available Research in perception and appreciation is often focused on snapshots, stills of experience. Static approaches allow for multidimensional assessment, but are unable to catch the crucial dynamics of affective and perceptual processes; for instance, aesthetic phenomena such as the ‘Aesthetic-Aha’ (the increase in liking after the sudden detection of Gestalt, effects of expectation, or Berlyne’s idea that ‘disorientation’ with a ‘promise of success’ elicits interest. We conducted empirical studies on indeterminate artistic movies depicting the evolution and metamorphosis of Gestalt and investigated (i the effects of sudden perceptual insights on liking; that is, Aesthetic Aha-effects, (ii the dynamics of interest before moments of insight, and (iii the dynamics of complexity before and after moments of insight. Via the so-called Continuous Evaluation Procedure (CEP enabling analogous evaluation in a continuous way, participants assessed the material on two aesthetic dimensions blockwise either in a gallery or a laboratory. The material’s inherent dynamics were described via assessments of liking, interest, determinacy and surprise along with a computational analysis on the variable complexity. We identified moments of insight as peaks in determinacy and surprise. Statistically significant changes in liking and interest demonstrated that: (i insights increase liking, (ii interest already increases 1,500 ms before such moments of insight, supporting the idea that it is evoked by an expectation of understanding, and (iii insights occur during increasing complexity. We propose a preliminary model of dynamics in liking and interest with regard to complexity and perceptual insight and discuss descriptions of participants’ experiences of insight. Our results point to the importance of systematic analyses of dynamics in art perception and appreciation.

  12. Efecto del kinesiotaping con y sin tensión aplicado en cuadríceps sobre la capacidad de salto en deportistas

    OpenAIRE

    Anaya, Mayerly Carolina; Díaz, Ingrid Johanna

    2015-01-01

    Antecedentes: Estudios previos han encontrado que la técnica del Kinesiotaping (KT) reduce la intensidad y duración del dolor y la inflamación, incrementa la fuerza muscular y estabiliza las articulaciones. Sin embargo, poco se conoce sobre su efecto para mejorar las capacidades físicas a través de la estimulación muscular en deportistas. Objetivo: Evaluar el efecto del KT aplicado en el cuadríceps sobre la capacidad de salto vertical en deportistas sanos, ajustado por el porcentaje de coordi...

  13. Keutuhan Membran Spermatozoa Disekuensing Sentrifugasi Gradien Densitas Percoll Berpengencer Andromed dan CEP-2 yang Ditambahkan Kuning Telur (MEMBRANE INTACT OF SPERMATOZOA FOLLOWING SEXING USING PERCOLL DENSITY GRADIENT CENTRIFUGATION IN ANDROMED AND C

    Directory of Open Access Journals (Sweden)

    Yudha Fika Diliyana

    2014-05-01

    Full Text Available The aim of this study was to observe the best extender in protecting the membrane of bovine spermatozoafollowing sexing by percoll density gradient centrifugation. Freshly collected semen were obtained fromBalai Besar Inseminasi Buatan Singosari-Malang. The semen were diluted in andromed and CaudalEpididymal Plasma-2 (CEP-2 added with 10% egg yolk extenders.The sperm membrane integrity wasobserved using Hypo-osmotic Swelling Test (HOST. Sperm capacitation and acrososome reaction wereassessed using Chlortetracycline Fluorescence Assay.The results showed that andromed and CEP-2 addedwith 10% egg yolk were able to retain the sperm membrane integrity, whereas sperm capacitation andacrosome reaction were kept low. Caudal Epididymal Plasma-2 (CEP-2 added with 10% egg yolk seemedto give better protection towards the sperm membrane intact in comparison to andromed extender.

  14. Reconstrução de ruptura crônica do tríceps distal sob a configuração de dupla fileira: nota técnica

    Directory of Open Access Journals (Sweden)

    Alexandre Firmino Paniago

    2015-10-01

    Full Text Available resumo Rupturas do tríceps distal são incomuns e podem ser de difícil diagnóstico, especialmente as parciais. Métodos de imagem, como USG e RNM, devem ser usados para a confirmação diagnóstica e para definição da extensão da lesão. O tratamento de escolha para as rupturas completas do tríceps é o cirúrgico, diferentemente das parciais, que dependem de fatores como dor, déficit funcional e expectativas do paciente. Descrevemos o caso de um paciente com ruptura parcial do tríceps distal após queda ao solo. Não foi diagnosticado no momento do primeiro atendimento e evoluiu com dor e grande perda funcional. O procedimento cirúr gico foi feito após nove meses do trauma, com a reconstrução do tríceps por meio de reforço com o tendão do semitendíneo ipsilateral e fixação no olécrano sob a configuração de dupla fileira. O paciente permaneceu imobilizado com tipoia por uma semana e iniciou-se, a partir daí, o ganho de amplitude de movimento (ADM passiva. Após três semanas foi liberado para o ganho de ADM ativa. O fortalecimento muscular iniciou-se após 12 semanas. Após seis meses do procedimento cirúrgico o paciente apresenta-se sem dor, ADM completa, força de extensão do cotovelo grau V e hipertrofia do tríceps. A técnica descrita se mostrou útil para o tratamento de rupturas do tendão do tríceps distal.

  15. CEP em Selfie: abordando sexting com adolescentes como forma de exposição virtual da sexualidade

    Directory of Open Access Journals (Sweden)

    Leonardo das Neves Leal

    2017-06-01

    Full Text Available Este artigo objetiva relatar e refletir sobre intervenções feitas pelo Centro de Estudos Psicológicos (CEP-RUA da Universidade Federal do Rio Grande (FURG acerca do compartilhamento de fotos com conteúdo sexual – sexting – entre adolescentes, a fim de colaborar com o desenvolvimento saudável desse público. Foram realizadas três intervenções no município entre os anos de 2014 e 2015, a primeira numa escola privada com cerca de 100 estudantes que estavam entre o 7º ano do Ensino Fundamental e o 3º ano do Ensino Médio, a segunda na zona rural da cidade com 25 participantes sendo eles adolescentes e responsáveis atendidos pela a equipe do Centro de Referência em Assistência Social (CRAS da área, a terceira foi feita com 120 adolescentes participantes de um projeto social. Para abordar a temática usou-se dinâmicas grupais, contextualizando a necessidade humana de se autorretratar, a exposição da sexualidade durante diferentes contextos históricos e com diferentes ferramentas, da arte à utilização de dispositivos eletrônicos como celulares, câmeras digitais e computadores. Além disso fez-se a apresentação dos dispositivos legais para proteção e acolhimento da vítima em casos de exposição indevida da imagem, principalmente disposições do Estatuto da Criança e do Adolescentes sobre direito a imagem e punição em caso do denunciado ter também até 18 anos incompletos. As intervenções revelaram que a maioria dos adolescentes já tinham conhecimentos prévios sobre o assunto, embora desconhecem-se o termo sexting, também predominou a culpabilização das vítimas quando se tratava de mulheres expostas. Afirmou-se a necessidade de investir na abordagem multidisciplinar da educação para sexualidade com intuito de desmistificar e desconstruir alguns tabus sobre o tema.      

  16. Performance tests of the 5 TW, 1 kHz, passively CEP-stabilized ELI-ALPS SYLOS few-cycle laser system (Conference Presentation)

    Science.gov (United States)

    Stanislauskas, Tomas; Budriūnas, Rimantas; Veitas, Gediminas; Gadonas, Darius; Adamonis, Jonas; Aleknavičius, Aidas; Masian, Gžegož; Kuprionis, Zenonas; Hoff, Dominik; Paulus, Gerhard G.; Börzsönyi, Ádám.; Toth, Szabolcs; Kovacs, Mate; Csontos, János; López-Martens, Rodrigo; Osvay, Károly

    2017-05-01

    ELI-ALPS in Hungary, one of the three pillars of the Extreme Light Infrastructure, aims at providing diverse light sources, including energetic attosecond pulses at the highest possible repetition rates. One of the main laser systems for driving plasma and gas-based HHG stages, is a state-of-the-art 1 kHz few-cycle laser called SYLOS. Targeted pulse parameters are an energy of 100 mJ and a duration shorter than two optical cycles (stability as well as high spatiotemporal quality. The first phase of the laser system has already set a new standard in kHz laser system engineering and technology. The performance and reliability of the SYLOS laser have been consistently tested over the course of a six-month trial period. During this time the system was running at least 8 hours a day at full power for more than 5 months. The current output parameters are 5 TW peak power, 45 mJ pulse energy with 9 fs duration and 300 mrad CEP stability, while the spectrum spans over 300 nm around 840 nm central wavelength. The layout follows the general scheme NOPCPA architecture with a passively CEP-stabilized front-end. The pulses are negatively chirped for the amplification process and compressed by a combination of large aperture bulk glass blocks and positively chirped mirrors under vacuum conditions at the output. During the trial period, the laser system demonstrated outstanding reliability. Daily startup and shutdown procedures take only a few minutes, and the command-control system enables pulse parameters to be modified instantly. Controlling the delays of individual NOPCPA stages makes it possible to tailor the output spectrum of the pulses and tune the central wavelength between 770 nm and 940 nm. We performed several experimental tests to find out the pulse characteristics. Pulse duration was verified with Wizzler, chirp-scan, autocorrelation methods and a stereo-ATI independently. All of them confirmed the sub-9 fs pulse duration. We recorded the long-term waveform and

  17. Congenital Erythropoietic Porphyria (CEP)

    Science.gov (United States)

    ... a shortened life-span, and anemia often results. Synthesis of heme and hemoglobin are actually increased to compensate for ... deficiencies of certain enzymes in the step-wise synthesis of heme, the essential component of hemoglobin and various hemo- ...

  18. Analyzing Peace Pedagogies

    Science.gov (United States)

    Haavelsrud, Magnus; Stenberg, Oddbjorn

    2012-01-01

    Eleven articles on peace education published in the first volume of the Journal of Peace Education are analyzed. This selection comprises peace education programs that have been planned or carried out in different contexts. In analyzing peace pedagogies as proposed in the 11 contributions, we have chosen network analysis as our method--enabling…

  19. Miniature mass analyzer

    CERN Document Server

    Cuna, C; Lupsa, N; Cuna, S; Tuzson, B

    2003-01-01

    The paper presents the concept of different mass analyzers that were specifically designed as small dimension instruments able to detect with great sensitivity and accuracy the main environmental pollutants. The mass spectrometers are very suited instrument for chemical and isotopic analysis, needed in environmental surveillance. Usually, this is done by sampling the soil, air or water followed by laboratory analysis. To avoid drawbacks caused by sample alteration during the sampling process and transport, the 'in situ' analysis is preferred. Theoretically, any type of mass analyzer can be miniaturized, but some are more appropriate than others. Quadrupole mass filter and trap, magnetic sector, time-of-flight and ion cyclotron mass analyzers can be successfully shrunk, for each of them some performances being sacrificed but we must know which parameters are necessary to be kept unchanged. To satisfy the miniaturization criteria of the analyzer, it is necessary to use asymmetrical geometries, with ion beam obl...

  20. Analog multivariate counting analyzers

    CERN Document Server

    Nikitin, A V; Armstrong, T P

    2003-01-01

    Characterizing rates of occurrence of various features of a signal is of great importance in numerous types of physical measurements. Such signal features can be defined as certain discrete coincidence events, e.g. crossings of a signal with a given threshold, or occurrence of extrema of a certain amplitude. We describe measuring rates of such events by means of analog multivariate counting analyzers. Given a continuous scalar or multicomponent (vector) input signal, an analog counting analyzer outputs a continuous signal with the instantaneous magnitude equal to the rate of occurrence of certain coincidence events. The analog nature of the proposed analyzers allows us to reformulate many problems of the traditional counting measurements, and cast them in a form which is readily addressed by methods of differential calculus rather than by algebraic or logical means of digital signal processing. Analog counting analyzers can be easily implemented in discrete or integrated electronic circuits, do not suffer fro...

  1. Variants of CEP68 Gene Are Associated with Acute Urticaria/Angioedema Induced by Multiple Non-Steroidal Anti-Inflammatory Drugs

    Science.gov (United States)

    Cornejo-García, José Antonio; Flores, Carlos; Plaza-Serón, María C.; Acosta-Herrera, Marialbert; Blanca-López, Natalia; Doña, Inmaculada; Torres, María J.; Mayorga, Cristobalina; Guéant-Rodríguez, Rosa M.; Ayuso, Pedro; Fernández, Javier; Laguna, José J.; Agúndez, José A. G.; García-Martín, Elena; Guéant, Jean-Louis; Canto, Gabriela; Blanca, Miguel

    2014-01-01

    Non-steroidal anti-inflammatory drugs (NSAIDs) are the most consumed drugs worldwide because of their efficacy and utility in the treatment of pain and inflammatory diseases. However, they are also responsible for an important number of adverse effects including hypersensitivity reactions. The most important group of these reactions is triggered by non-immunological, pharmacological mechanisms catalogued under the denomination of cross-intolerance (CRI), with acute urticaria/angioedema induced by multiple NSAIDs (MNSAID-UA) the most frequently associated clinical entity. A recent genome-wide association study identified the gene encoding the centrosomal protein of 68 KDa (CEP68) as the major locus associated with aspirin intolerance susceptibility in asthmatics. In this study, we aimed to assess the role of this locus in susceptibility to CRI to NSAIDs by examining 53 common gene variants in a total of 635 patients that were classified as MNSAID-UA (n = 399), airway exacerbations (n = 110) or blended pattern (n = 126), and 425 controls. We found in the MNSAID-UA group a number of variants (17) associated (lowest p-value = 1.13×10−6), including the non-synonymous Gly74Ser variant (rs7572857) previously associated with aspirin intolerance susceptibility in asthmatics. Although not being significant in the context of multiple testing, eight of these variants were also associated with exacerbated respiratory disease or blended reactions. Our results suggest that CEP68 gene variants may play an important role in MNSAID-UA susceptibility and, despite the different regulatory mechanisms involved depending on the specific affected organ, in the development of hypersensitivity reactions to NSAIDs. PMID:24618698

  2. [Healthy pharmaceutical policy].

    Science.gov (United States)

    González Pier, Eduardo

    2008-01-01

    Today, the pharmaceutical industry is experiencing a profound transition. Globalization and technological advancement represent the principal pressures for change in the market, where it is increasingly more difficult for this type of industry to efficiently recoup the growing cost of innovation. Mexico needs to analyze the policy implications of these change factors and promote, in the pharmaceutical market, policies that maximize health gains on invested resources. Pharmaceutical policy offers a rare example for a complementary approach between a sound health policy and an efficient economic policy; that is, a "healthy pharmaceutical policy."

  3. Analyzing Stereotypes in Media.

    Science.gov (United States)

    Baker, Jackie

    1996-01-01

    A high school film teacher studied how students recognized messages in film, examining how film education could help students identify and analyze racial and gender stereotypes. Comparison of students' attitudes before and after the film course found that the course was successful in raising students' consciousness. (SM)

  4. Centrifugal analyzer development

    International Nuclear Information System (INIS)

    Burtis, C.A.; Bauer, M.L.; Bostick, W.D.

    1976-01-01

    The development of the centrifuge fast analyzer (CFA) is reviewed. The development of a miniature CFA with computer data analysis is reported and applications for automated diagnostic chemical and hematological assays are discussed. A portable CFA system with microprocessor was adapted for field assays of air and water samples for environmental pollutants, including ammonia, nitrates, nitrites, phosphates, sulfates, and silica. 83 references

  5. Americal options analyzed differently

    NARCIS (Netherlands)

    Nieuwenhuis, J.W.

    2003-01-01

    In this note we analyze in a discrete-time context and with a finite outcome space American options starting with the idea that every tradable should be a martingale under a certain measure. We believe that in this way American options become more understandable to people with a good working

  6. Analyzed Using Statistical Moments

    International Nuclear Information System (INIS)

    Oltulu, O.

    2004-01-01

    Diffraction enhanced imaging (DEl) technique is a new x-ray imaging method derived from radiography. The method uses a monorheumetten x-ray beam and introduces an analyzer crystal between an object and a detector Narrow angular acceptance of the analyzer crystal generates an improved contrast over the evaluation radiography. While standart radiography can produce an 'absorption image', DEl produces 'apparent absorption' and 'apparent refraction' images with superior quality. Objects with similar absorption properties may not be distinguished with conventional techniques due to close absorption coefficients. This problem becomes more dominant when an object has scattering properties. A simple approach is introduced to utilize scattered radiation to obtain 'pure absorption' and 'pure refraction' images

  7. Charged particle analyzer PLAZMAG

    International Nuclear Information System (INIS)

    Apathy, Istvan; Endroeczy, Gabor; Szemerey, Istvan; Szendroe, Sandor

    1985-01-01

    The scientific task of the charged particle analyzer PLAZMAG, a part of the VEGA space probe, and the physical background of the measurements are described. The sensor of the device face the Sun and the comet Halley measuring the energy and mass spectrum of ion and electron components of energies lower than 25 keV. The tasks of the individual electronic parts, the design aspects and the modes of operation in different phases of the flight are dealt with. (author)

  8. Relating Actor Analysis Methods to Policy Problems

    NARCIS (Netherlands)

    Van der Lei, T.E.

    2009-01-01

    For a policy analyst the policy problem is the starting point for the policy analysis process. During this process the policy analyst structures the policy problem and makes a choice for an appropriate set of methods or techniques to analyze the problem (Goeller 1984). The methods of the policy

  9. Fractional channel multichannel analyzer

    Science.gov (United States)

    Brackenbush, L.W.; Anderson, G.A.

    1994-08-23

    A multichannel analyzer incorporating the features of the present invention obtains the effect of fractional channels thus greatly reducing the number of actual channels necessary to record complex line spectra. This is accomplished by using an analog-to-digital converter in the asynchronous mode, i.e., the gate pulse from the pulse height-to-pulse width converter is not synchronized with the signal from a clock oscillator. This saves power and reduces the number of components required on the board to achieve the effect of radically expanding the number of channels without changing the circuit board. 9 figs.

  10. Plutonium solution analyzer

    International Nuclear Information System (INIS)

    Burns, D.A.

    1994-09-01

    A fully automated analyzer has been developed for plutonium solutions. It was assembled from several commercially available modules, is based upon segmented flow analysis, and exhibits precision about an order of magnitude better than commercial units (0.5%-O.05% RSD). The system was designed to accept unmeasured, untreated liquid samples in the concentration range 40-240 g/L and produce a report with sample identification, sample concentrations, and an abundance of statistics. Optional hydraulics can accommodate samples in the concentration range 0.4-4.0 g/L. Operating at a typical rate of 30 to 40 samples per hour, it consumes only 0.074 mL of each sample and standard, and generates waste at the rate of about 1.5 mL per minute. No radioactive material passes through its multichannel peristaltic pump (which remains outside the glovebox, uncontaminated) but rather is handled by a 6-port, 2-position chromatography-type loop valve. An accompanying computer is programmed in QuickBASIC 4.5 to provide both instrument control and data reduction. The program is truly user-friendly and communication between operator and instrument is via computer screen displays and keyboard. Two important issues which have been addressed are waste minimization and operator safety (the analyzer can run in the absence of an operator, once its autosampler has been loaded)

  11. Ring Image Analyzer

    Science.gov (United States)

    Strekalov, Dmitry V.

    2012-01-01

    Ring Image Analyzer software analyzes images to recognize elliptical patterns. It determines the ellipse parameters (axes ratio, centroid coordinate, tilt angle). The program attempts to recognize elliptical fringes (e.g., Newton Rings) on a photograph and determine their centroid position, the short-to-long-axis ratio, and the angle of rotation of the long axis relative to the horizontal direction on the photograph. These capabilities are important in interferometric imaging and control of surfaces. In particular, this program has been developed and applied for determining the rim shape of precision-machined optical whispering gallery mode resonators. The program relies on a unique image recognition algorithm aimed at recognizing elliptical shapes, but can be easily adapted to other geometric shapes. It is robust against non-elliptical details of the image and against noise. Interferometric analysis of precision-machined surfaces remains an important technological instrument in hardware development and quality analysis. This software automates and increases the accuracy of this technique. The software has been developed for the needs of an R&TD-funded project and has become an important asset for the future research proposal to NASA as well as other agencies.

  12. Plutonium solution analyzer

    Energy Technology Data Exchange (ETDEWEB)

    Burns, D.A.

    1994-09-01

    A fully automated analyzer has been developed for plutonium solutions. It was assembled from several commercially available modules, is based upon segmented flow analysis, and exhibits precision about an order of magnitude better than commercial units (0.5%-O.05% RSD). The system was designed to accept unmeasured, untreated liquid samples in the concentration range 40-240 g/L and produce a report with sample identification, sample concentrations, and an abundance of statistics. Optional hydraulics can accommodate samples in the concentration range 0.4-4.0 g/L. Operating at a typical rate of 30 to 40 samples per hour, it consumes only 0.074 mL of each sample and standard, and generates waste at the rate of about 1.5 mL per minute. No radioactive material passes through its multichannel peristaltic pump (which remains outside the glovebox, uncontaminated) but rather is handled by a 6-port, 2-position chromatography-type loop valve. An accompanying computer is programmed in QuickBASIC 4.5 to provide both instrument control and data reduction. The program is truly user-friendly and communication between operator and instrument is via computer screen displays and keyboard. Two important issues which have been addressed are waste minimization and operator safety (the analyzer can run in the absence of an operator, once its autosampler has been loaded).

  13. Analyzing Water's Optical Absorption

    Science.gov (United States)

    2002-01-01

    A cooperative agreement between World Precision Instruments (WPI), Inc., and Stennis Space Center has led the UltraPath(TM) device, which provides a more efficient method for analyzing the optical absorption of water samples at sea. UltraPath is a unique, high-performance absorbance spectrophotometer with user-selectable light path lengths. It is an ideal tool for any study requiring precise and highly sensitive spectroscopic determination of analytes, either in the laboratory or the field. As a low-cost, rugged, and portable system capable of high- sensitivity measurements in widely divergent waters, UltraPath will help scientists examine the role that coastal ocean environments play in the global carbon cycle. UltraPath(TM) is a trademark of World Precision Instruments, Inc. LWCC(TM) is a trademark of World Precision Instruments, Inc.

  14. PDA: Pooled DNA analyzer

    Directory of Open Access Journals (Sweden)

    Lin Chin-Yu

    2006-04-01

    Full Text Available Abstract Background Association mapping using abundant single nucleotide polymorphisms is a powerful tool for identifying disease susceptibility genes for complex traits and exploring possible genetic diversity. Genotyping large numbers of SNPs individually is performed routinely but is cost prohibitive for large-scale genetic studies. DNA pooling is a reliable and cost-saving alternative genotyping method. However, no software has been developed for complete pooled-DNA analyses, including data standardization, allele frequency estimation, and single/multipoint DNA pooling association tests. This motivated the development of the software, 'PDA' (Pooled DNA Analyzer, to analyze pooled DNA data. Results We develop the software, PDA, for the analysis of pooled-DNA data. PDA is originally implemented with the MATLAB® language, but it can also be executed on a Windows system without installing the MATLAB®. PDA provides estimates of the coefficient of preferential amplification and allele frequency. PDA considers an extended single-point association test, which can compare allele frequencies between two DNA pools constructed under different experimental conditions. Moreover, PDA also provides novel chromosome-wide multipoint association tests based on p-value combinations and a sliding-window concept. This new multipoint testing procedure overcomes a computational bottleneck of conventional haplotype-oriented multipoint methods in DNA pooling analyses and can handle data sets having a large pool size and/or large numbers of polymorphic markers. All of the PDA functions are illustrated in the four bona fide examples. Conclusion PDA is simple to operate and does not require that users have a strong statistical background. The software is available at http://www.ibms.sinica.edu.tw/%7Ecsjfann/first%20flow/pda.htm.

  15. ROTC Policy Regarding Homosexuals

    Directory of Open Access Journals (Sweden)

    Lee S. Duemer

    1997-03-01

    Full Text Available This is a policy analysis, in a historical context, of how Association of American University institutions responded to Reserve Officer Training Corps policy excluding homosexuals. The time period for this study is 1982 to 1992. Qualitative methods are used to analyze data and arrive at conclusions. Secondary data provide additional depth and background. This study reveals seven different positions institutions have taken in response to ROTC policy, these include: supporting ROTC policy, neutrality, collective action, barring military recruiters from campus, distancing the institution from ROTC, and changing the campus climate. This includes examples taken from AAU institutions and rationales behind making policy decisions.

  16. Modelo para implementação das ferramentas básicas do controle estatístico do processo - CEP em pequenas e médias empresas manufatureiras

    OpenAIRE

    Galuch, Lucia

    2002-01-01

    Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia de Produção. Esta dissertação mostra as Ferramentas Básicas do Controle Estatístico do Processo - CEP, com o objetivo de propor um Modelo de Implementação numa empresa de móveis de aço de pequeno porte. A partir do estudo bibliográfico a dissertação apresenta os conceitos das Ferramentas Básicas do CEP e técnicas de implantação de um Controle Estatístico do Processo....

  17. Downhole Fluid Analyzer Development

    Energy Technology Data Exchange (ETDEWEB)

    Bill Turner

    2006-11-28

    A novel fiber optic downhole fluid analyzer has been developed for operation in production wells. This device will allow real-time determination of the oil, gas and water fractions of fluids from different zones in a multizone or multilateral completion environment. The device uses near infrared spectroscopy and induced fluorescence measurement to unambiguously determine the oil, water and gas concentrations at all but the highest water cuts. The only downhole components of the system are the fiber optic cable and windows. All of the active components--light sources, sensors, detection electronics and software--will be located at the surface, and will be able to operate multiple downhole probes. Laboratory testing has demonstrated that the sensor can accurately determine oil, water and gas fractions with a less than 5 percent standard error. Once installed in an intelligent completion, this sensor will give the operating company timely information about the fluids arising from various zones or multilaterals in a complex completion pattern, allowing informed decisions to be made on controlling production. The research and development tasks are discussed along with a market analysis.

  18. PULSE HEIGHT ANALYZER

    Science.gov (United States)

    Johnstone, C.W.

    1958-01-21

    An anticoincidence device is described for a pair of adjacent channels of a multi-channel pulse height analyzer for preventing the lower channel from generating a count pulse in response to an input pulse when the input pulse has sufficient magnitude to reach the upper level channel. The anticoincidence circuit comprises a window amplifier, upper and lower level discriminators, and a biased-off amplifier. The output of the window amplifier is coupled to the inputs of the discriminators, the output of the upper level discriminator is connected to the resistance end of a series R-C network, the output of the lower level discriminator is coupled to the capacitance end of the R-C network, and the grid of the biased-off amplifier is coupled to the junction of the R-C network. In operation each discriminator produces a negative pulse output when the input pulse traverses its voltage setting. As a result of the connections to the R-C network, a trigger pulse will be sent to the biased-off amplifier when the incoming pulse level is sufficient to trigger only the lower level discriminator.

  19. Analyzing Spacecraft Telecommunication Systems

    Science.gov (United States)

    Kordon, Mark; Hanks, David; Gladden, Roy; Wood, Eric

    2004-01-01

    Multi-Mission Telecom Analysis Tool (MMTAT) is a C-language computer program for analyzing proposed spacecraft telecommunication systems. MMTAT utilizes parameterized input and computational models that can be run on standard desktop computers to perform fast and accurate analyses of telecommunication links. MMTAT is easy to use and can easily be integrated with other software applications and run as part of almost any computational simulation. It is distributed as either a stand-alone application program with a graphical user interface or a linkable library with a well-defined set of application programming interface (API) calls. As a stand-alone program, MMTAT provides both textual and graphical output. The graphs make it possible to understand, quickly and easily, how telecommunication performance varies with variations in input parameters. A delimited text file that can be read by any spreadsheet program is generated at the end of each run. The API in the linkable-library form of MMTAT enables the user to control simulation software and to change parameters during a simulation run. Results can be retrieved either at the end of a run or by use of a function call at any time step.

  20. Dynamic model to analyze pedestrian traffic policies in Bogota

    Directory of Open Access Journals (Sweden)

    Germán Méndez-Giraldo

    2014-01-01

    Full Text Available Los sistemas peatonales cobran cada vez más importancia en la planeación del transporte en las ciudades, sin embargo, los enfoques utilizados para su análisis y representación son de tipo microscópico y no son adecuados para la toma de decisiones en el nivel estratégico de los sistemas peatonales; principalmente, porque en ellos se presentan relaciones de realimentación entre los diferentes niveles, que no se pueden representar fácilmente de esa manera. En este artículo se presenta un prototipo para el análisis del nivel estratégico de los sistemas peatonales, haciendo uso de la dinámica industrial. Este enfoque permite representar las relaciones de realimentación propias de estos sistemas, a través del uso de información tanto cuantitativa como cualitativa, para analizar las respuestas del sistema en el largo plazo. Se concluye que el prototipo propuesto permite ser un soporte para la toma de decisiones estratégicas de estos sistemas.

  1. Analyzing Global Interdependence. Volume I. Analytical Perspectives and Policy Implications,

    Science.gov (United States)

    1974-11-01

    bureaucratic politics and organizational reform, including the more interesting cases of transgovernmental cooperation among particular military services...preferred model would be what Falk has termed "multi-level transnationality ," involving a mix of regional, national, international, and transnational...4) a concommitant awareness of the transnational and transgovernmental pluralization of actor issues and objectives; (5) a methodological interest in

  2. Soft Decision Analyzer

    Science.gov (United States)

    Steele, Glen; Lansdowne, Chatwin; Zucha, Joan; Schlensinger, Adam

    2013-01-01

    The Soft Decision Analyzer (SDA) is an instrument that combines hardware, firmware, and software to perform realtime closed-loop end-to-end statistical analysis of single- or dual- channel serial digital RF communications systems operating in very low signal-to-noise conditions. As an innovation, the unique SDA capabilities allow it to perform analysis of situations where the receiving communication system slips bits due to low signal-to-noise conditions or experiences constellation rotations resulting in channel polarity in versions or channel assignment swaps. SDA s closed-loop detection allows it to instrument a live system and correlate observations with frame, codeword, and packet losses, as well as Quality of Service (QoS) and Quality of Experience (QoE) events. The SDA s abilities are not confined to performing analysis in low signal-to-noise conditions. Its analysis provides in-depth insight of a communication system s receiver performance in a variety of operating conditions. The SDA incorporates two techniques for identifying slips. The first is an examination of content of the received data stream s relation to the transmitted data content and the second is a direct examination of the receiver s recovered clock signals relative to a reference. Both techniques provide benefits in different ways and allow the communication engineer evaluating test results increased confidence and understanding of receiver performance. Direct examination of data contents is performed by two different data techniques, power correlation or a modified Massey correlation, and can be applied to soft decision data widths 1 to 12 bits wide over a correlation depth ranging from 16 to 512 samples. The SDA detects receiver bit slips within a 4 bits window and can handle systems with up to four quadrants (QPSK, SQPSK, and BPSK systems). The SDA continuously monitors correlation results to characterize slips and quadrant change and is capable of performing analysis even when the

  3. Financial globalization and monetary policy

    OpenAIRE

    Devereux, Michael B.; Sutherland, Alan

    2008-01-01

    The process of financial globalization has significantly altered the environment in which national monetary policy authorities operate. What implications does this have for the design of monetary policy? The question can be properly addressed only in the context of a model where monetary policy interacts with financial market efficiency. This paper is concerned with the effects of monetary policy when international portfolio choice is endogenous. We analyze the link between monetary policy an...

  4. Multichannel analyzer development in CAMAC

    International Nuclear Information System (INIS)

    Nagy, J.Z.; Zarandy, A.

    1988-01-01

    The data acquisition in TOKAMAK experiments some CAMAC modules have been developed. The modules are the following: 64 K analyzer memory, 32 K analyzer memory, 6-channel pulse peak analyzer memory which contains the 32 K analyzer memory and eight AD-converters

  5. Tough Policies, Incredible Policies?

    OpenAIRE

    Andres Velasco; Alejandro Neut

    2003-01-01

    We revisit the question of what determines the credibility of macroeconomic policies here, of promises to repay public debt. Almost all thinking on the issue has focused on governments' strategic decision to default (or erode the value of outstanding debt via inflation/devaluation). But sometimes governments default not because they want to, but because they cannot avoid it: adverse shocks leave them no option. We build a model in which default/devaluation can occur deliberately (for strategi...

  6. Efeito do treinamento resistido na avaliação da composição corporal e na atividade da MMP-2 nos músculos bíceps e gastrocnêmio de ratos obesos

    OpenAIRE

    Markus Vinicius Campos Souza

    2013-01-01

    O objetivo do presente estudo, foi investigar a influência do treinamento resistido na composição corporal e a atividade metaloproteinases de matrix 2 (MMP-2) nos músculos bíceps e gastrocnêmio em ratos alimentados com dieta hiperlipídica. Foram avaliados 32 ratos machos Wistar divididos em quarto grupos experimentais (n=8/cada) de acordo com o tipo de dieta e o treinamento: Controle (C; dieta padrão), Controle Obeso [C-Ob; dieta: hiperlipídica (30% de gordura)], Exercício Resistido (EX; diet...

  7. PM 3655 PHILIPS Logic analyzer

    CERN Multimedia

    A logic analyzer is an electronic instrument that captures and displays multiple signals from a digital system or digital circuit. A logic analyzer may convert the captured data into timing diagrams, protocol decodes, state machine traces, assembly language, or may correlate assembly with source-level software. Logic Analyzers have advanced triggering capabilities, and are useful when a user needs to see the timing relationships between many signals in a digital system.

  8. Digital Multi Channel Analyzer Enhancement

    International Nuclear Information System (INIS)

    Gonen, E.; Marcus, E.; Wengrowicz, U.; Beck, A.; Nir, J.; Sheinfeld, M.; Broide, A.; Tirosh, D.

    2002-01-01

    A cement analyzing system based on radiation spectroscopy had been developed [1], using novel digital approach for real-time, high-throughput and low-cost Multi Channel Analyzer. The performance of the developed system had a severe problem: the resulted spectrum suffered from lack of smoothness, it was very noisy and full of spikes and surges, therefore it was impossible to use this spectrum for analyzing the cement substance. This paper describes the work carried out to improve the system performance

  9. Detection of B. fragilis group and diversity of bft enterotoxin and antibiotic resistance markers cepA, cfiA and nim among intestinal Bacteroides fragilis strains in patients with inflammatory bowel disease.

    Science.gov (United States)

    Rashidan, Marjan; Azimirad, Masoumeh; Alebouyeh, Masoud; Ghobakhlou, Mehdi; Asadzadeh Aghdaei, Hamid; Zali, Mohammad Reza

    2018-04-01

    We compared frequency of the members of B. fragilis group in 100 and 20 colon biopsy specimens of inflammatory bowel disease (IBD) and non-IBD patients. Agar dilution and PCR were orderly used to detect minimal inhibitory concentration of ampicillin, imipenem, and metronidazole, and carriage of related resistance genes cepA, cfi, and nim. B. fragilis group was detected in 38% of IBD (UC: 36/89; CD:1/11) and 25% (5/20) of non-IBD patients. While B. vulgatus (UC: 20/36, CD: 1/2, control: 1/6); B. fragilis (UC: 18/36, CD: 1/2, control: 5/6); B. ovatus (UC: 2/36); B. caccae (UC: 1/36); and B. eggerthii (UC: 1/36) were characterized, colonization of B. thetaiotamicron, B. merdae, B. distasonis, B. stercoris and B. dorei species was not detected in these specimens. Co-existence of B. fragilis + B. vulgatus (5 patients) and B. vulgatus + B. caccae (1 patient) was detected just in UC patients. bft was detected among 31.5% (6/19) of B. fragilis strains in the IBD and 40% (2/5) in the non-IBD groups. Nearly, 73.6% of the strains from the patient group and 80% in control group harbored cepA; 31.5% and 20% in the patients and control groups harbored cfiA, and none of them harbored nim determinant. Co-occurrence of the cepA and cfiA was orderly detected in 10.5% (2/19) and 20% (1/5) of the strains in these groups. The resistance rates were detected as 95.8% (23/24 (to ampicillin (MIC range of ≤0.5-≥16 μg/ml), 0% to metronidazole and 29.1% to imipenem (7/24, MIC range ≤4-32 μg/ml). Nearly 25% (6/24) of the strains were resistant to ampicillin and imipenem, simultaneously. No statistically significant difference was detected between the IBD and control groups for drug resistance phenotypes. Statistical analysis showed significant associations between resistance to ampicillin or imipenem and carriage of cepA or cfiA, respectively (p value = 0.0007). PCR results on the extracted plasmids confirmed their roles in carriage of cfiA and cepA. These

  10. [Epidemiology and public policies].

    Science.gov (United States)

    Barata, Rita Barradas

    2013-03-01

    The present essay deals with the relation between epidemiology and public policies, highlighting the epidemiology position in the public health field, analyzing the impact of public policies over epidemiological profile and contributions from epidemiology to the lay down, implementation and evaluation of public health policies. In the first title, the essay debates the links between the epidemiology and public health field, the social determinants and political action framework proposed by the WHO's Commission on Social Determinants of Health, and different approaches of health policies. In the second title the essay analyses the reduction of child stunting in Brazil as an example of public policies that impact epidemiological profile. The third title presents three strategic topics for the application of public health policies: reduction of social inequalities in health, health promotion and regulation of products and services that have impact over health. The fourth title discusses the possibilities and difficulties to combine the epidemiological knowledge in the lay down, implementation and evaluation of public policies and, finally, material examples of such relation between epidemiology and public policies are presented.

  11. Multichannel analyzer type CMA-3

    International Nuclear Information System (INIS)

    Czermak, A.; Jablonski, J.; Ostrowicz, A.

    1978-01-01

    Multichannel analyzer CMA-3 is designed for two-parametric analysis with operator controlled logical windows. It is implemented in CAMAC standard. A single crate contains all required modules and is controlled by the PDP-11/10 minicomputer. Configuration of CMA-3 is shown. CMA-3 is the next version of the multichannel analyzer described in report No 958/E-8. (author)

  12. Comparison of fiber length analyzers

    Science.gov (United States)

    Don Guay; Nancy Ross Sutherland; Walter Rantanen; Nicole Malandri; Aimee Stephens; Kathleen Mattingly; Matt Schneider

    2005-01-01

    In recent years, several fiber new fiber length analyzers have been developed and brought to market. The new instruments provide faster measurements and the capability of both laboratory and on-line analysis. Do the various fiber analyzers provide the same length, coarseness, width, and fines measurements for a given fiber sample? This paper provides a comparison of...

  13. Política de financiamento da educação superior – análise dos Planos Nacionais de Educação pós-constituição/1988. Higher education funding policyanalyze of the National Education Plans post-constitution/1988

    Directory of Open Access Journals (Sweden)

    Vera Lúcia Jacob Chaves

    2014-05-01

    Full Text Available The purpose of this article is to analyze the Brazilian public higher education funding policy, as it appears in the I National Education Plan (PNE post-Federal Constitution of 1988 and the content of proposed legislation (PL 8.035/2010. The study arises from the thesis that the public higher education funding is directly related to the federal fiscal adjustment policy, implemented in Brazil in the 90’s, as part of the neoliberal reforms adopted in capitalist countries, particularly in Latin America. These reforms follow the guidelines of international organizations, in particular the World Bank, the International Monetary Fund and the Organization for economic cooperation and development. Documental sources and data collected in Anísio Teixeira Study and Research Institute (Instituto Nacional de Estudos e Pesquisas Educacionais Anísio Teixeira - INEP, National Congress, United Nations Educational, Scientific and Cultural Organization (UNESCO and Central Intelligence Agency (CIA were used. The text reflects on the financing policy of Brazilian public higher education, establishing an interface between expansion targets proposed in National Education Plans and the percentage of GDP needed. On the final considerations, a comparison of the values applied throughout Brazil and other OCDE countries per person in educational age in higher education is made, identifying the existing distance between Brazil and the other countries. O artigo tem por objetivo analisar a política de financiamento da educação superior pública brasileira presente no I Plano Nacional de Educação (PNE pós Constituição Federal de 1988 e a proposta contida no Projeto de Lei 8.035/2010. O estudo parte da tese de que o financiamento da educação superior pública está diretamente relacionado à política de ajuste fiscal do Estado implementada no Brasil dos anos 1990, como parte das reformas neoliberais adotadas nos países capitalistas, em especial na Am

  14. Nuclear fuel microsphere gamma analyzer

    International Nuclear Information System (INIS)

    Valentine, K.H.; Long, E.L. Jr.; Willey, M.G.

    1977-01-01

    A gamma analyzer system is provided for the analysis of nuclear fuel microspheres and other radioactive particles. The system consists of an analysis turntable with means for loading, in sequence, a plurality of stations within the turntable; a gamma ray detector for determining the spectrum of a sample in one section; means for analyzing the spectrum; and a receiver turntable to collect the analyzed material in stations according to the spectrum analysis. Accordingly, particles may be sorted according to their quality; e.g., fuel particles with fractured coatings may be separated from those that are not fractured, or according to other properties. 4 claims, 3 figures

  15. Environmental policies in competitive electricity markets

    NARCIS (Netherlands)

    Langestraat, R.

    2013-01-01

    In this thesis we model and analyze several environmental policies in an existing mathematical representation of a perfectly competitive electricity market. We contribute to the literature by theoretically and numerically establishing a number of effects of environmental policies on investment

  16. Market study: Whole blood analyzer

    Science.gov (United States)

    1977-01-01

    A market survey was conducted to develop findings relative to the commercialization potential and key market factors of the whole blood analyzer which is being developed in conjunction with NASA's Space Shuttle Medical System.

  17. CSTT Update: Fuel Quality Analyzer

    Energy Technology Data Exchange (ETDEWEB)

    Brosha, Eric L. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Lujan, Roger W. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Mukundan, Rangachary [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Rockward, Tommy [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Romero, Christopher J. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Williams, Stefan [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Wilson, Mahlon S. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2018-02-06

    These are slides from a presentation. The following topics are covered: project background (scope and approach), developing the prototype (timeline), update on intellectual property, analyzer comparisons (improving humidification, stabilizing the baseline, applying clean-up strategy, impact of ionomer content and improving clean-up), proposed operating mode, considerations for testing in real-world conditions (Gen 1 analyzer electronics development, testing partner identified, field trial planning), summary, and future work.

  18. Rotura del Bíceps Distal. Evaluación de resultados con técnica de doble fijación. [Distal biceps rupture: evaluation of results with double fixation technique

    Directory of Open Access Journals (Sweden)

    Miguel Ángel Capomassi

    2013-11-01

    Full Text Available In­tro­duc­ción La rotura del bíceps distal es una lesión poco frecuente producida por la aplicación de una fuerza excéntrica sobre el codo flexionado. El objetivo de este trabajo es analizar los resultados obtenidos para la reinserción del bíceps distal mediante técnica de doble fijación con botón de anclaje cortical y tornillo interferencial de biotenodesis a través de una incisión anterior única. Materiales­ y­ Métodos Entre agosto de 2008 y febrero de 2013, registramos 19 casos de rotura del bíceps distal tratados quirúrgicamente por vía anterior limitada. Los 17 últimos casos consecutivos fueron tratados con doble fijación utilizando botón extracortical y tornillo de biotenodesis, y forman parte del estudio. Todos eran hombres, con una mediana de la edad de 41 años (rango 27-59. Los pacientes fueron evaluados con el Cuestionario DASH y el Puntaje Subjetivo/Objetivo de Andrews y Carson, y la fuerza de flexión y supinación se controló con la escala del British Medical Research Council modificada por Mackinnon y Dellon (M0-M5. Resultados El cuestionario DASH arrojó un valor mediano de 1,7 (0-5,83 y el de Andrews y Carson, de 195 (170-200 para el total; con 15 resultados excelentes y 2 buenos. Todos consiguieron una fuerza M5 para flexión y supinación de antebrazo. El seguimiento tuvo una mediana de 12 meses (4-32. En dos pacientes, se registraron complicaciones, ambas con recuperación ad íntegrum. Conclusión La técnica descrita ha demostrado ser confiable y eficaz, y permitió lograr resultados satisfactorios y una baja tasa de complicaciones.

  19. Estudo eletromiográfico dos músculos deltoide, peitoral maior e tríceps braquial de nadadores durante contrações bilaterais realizadas em exercício multiarticular com cargas variadas

    Directory of Open Access Journals (Sweden)

    Fernando Nazário-de-Rezende

    2012-04-01

    Full Text Available O objetivo deste trabalho foi comparar a atividade elétrica do músculo deltoide (porção média, peitoral maior (porção clavicular e tríceps braquial (cabeça longa durante contração bilateral realizada num aparelho multiarticular de desenvolvimento articulado convergente, com 40% e 80% da carga voluntária máxima (CVM, em 11 nadadores do gênero masculino (idades entre 15 e 23 anos, peso 70 ± 4kg, estatura 183 ± 6cm e tempo de prática do esporte de 10 ± 4 anos treinados em exercícios resistidos. Os sinais eletromiográficos (EMG foram captados através da colocação de eletrodos ativos de superfície diferenciais de ganho de 20 vezes, composto por duas barras retangulares paralelas da EMG System do Brasil, um eletrodo de referência (terra, e um módulo condicionador de sinais (eletromiógrafo, com aquisição simultânea de até oito canais diferenciais, filtro com faixa de passagem de 20Hz a 5Hz, estágio amplificador ajustável, possibilitando ganhos entre 100 e 4.960 vezes, impedância de entrada de canais de 10GΩ em módulos diferencial e CMRR de 93db a 60Hz, e um sistema de aquisição de dados (Alc-EMG que forneceu dados numéricos em RMS (raiz quadrada da média para análise dos resultados. Cada sinal coletado captou apenas a fase concêntrica do movimento e o mesmo teve duração de três segundos. Diante dos resultados (teste U de Mann-Whitney, Friedman e Wilcoxon conclui-se que, em termos práticos de prescrição e periodização do treinamento neuromuscular, as contrações bilaterais realizadas no aparelho desenvolvimento articulado convergente são eficientes visando recrutamento (80% > 40% dos músculos deltoide médio, peitoral maior (porção clavicular e tríceps braquial (cabeça longa, sendo evidenciadas diferenças entre o membro dominante e o não dominante apenas para o tríceps braquial dominante com a carga de 80% da CVM nestes atletas nadadores com histórico de treinamento com pesos.

  20. The new health policy

    National Research Council Canada - National Science Library

    Gauld, Robin

    2009-01-01

    ... Gauld brings together in one volume a comprehensive picture of the health policy challenges facing contemporary developed world health systems, as well as the strategies for tackling these. Individual chapters analyze: Challenges in health care funding and organization Quality and patient safety The application of information te...

  1. Globalization, crises and industrial policy; Globalizacion, crisis y politica industrial

    Energy Technology Data Exchange (ETDEWEB)

    Vives, X.

    2013-06-01

    In this paper we review the fundamentals of industrial policy and its implementation in the European context. We also analyze the relationship between industrial policy and competition policy. (Author) 6 refs.

  2. Evidence, Ethics & Social Policy Dilemmas

    OpenAIRE

    Steven I. Miller; L. Arthur Safer

    1993-01-01

    Within the philosophy of the social sciences, the relationship between evidence, ethics, and social policy is in need of further analysis. The present paper is an attempt to argue that while important social policies can, and perhaps ought to be, grounded in ethical theory, they are seldom articulated in this fashion due to the ambiguity surrounding the "evidence condition." Using a consequentialist-utilitarian framework, and a case study of a policy dilemma, the authors analyze the difficult...

  3. Compact analyzer: an interactive simulator

    International Nuclear Information System (INIS)

    Ipakchi, A.; Khadem, M.; Colley, R.W.

    1985-01-01

    Compact Analyzer is a computer system that combines dynamic simulation models with interactive and color graphics user interface functions to provide a cost-effective simulator for dynamic analysis and evaluation of power plant operation, with engineering and training applications. Most dynamic simulation packages such as RETRAN and TRAC are designed for a batch-mode operation. With advancements in computer technology and man/machine interface capabilities, it is possible to integrate such codes with interactive and graphic functions into advanced simulators. The US Nuclear Regulatory Commission has sponsored development of plant analyzers with such characteristics. The Compact Analyzer is an Electric Power Research Institute (EPRI)-sponsored project, which currently utilizes the EPRI modular modeling system (MMS) for process simulation, and uses an adaptable color graphic package for dynamic display of the simulation results

  4. On-Demand Urine Analyzer

    Science.gov (United States)

    Farquharson, Stuart; Inscore, Frank; Shende, Chetan

    2010-01-01

    A lab-on-a-chip was developed that is capable of extracting biochemical indicators from urine samples and generating their surface-enhanced Raman spectra (SERS) so that the indicators can be quantified and identified. The development was motivated by the need to monitor and assess the effects of extended weightlessness, which include space motion sickness and loss of bone and muscle mass. The results may lead to developments of effective exercise programs and drug regimes that would maintain astronaut health. The analyzer containing the lab-on-a- chip includes materials to extract 3- methylhistidine (a muscle-loss indicator) and Risedronate (a bone-loss indicator) from the urine sample and detect them at the required concentrations using a Raman analyzer. The lab-on- a-chip has both an extractive material and a SERS-active material. The analyzer could be used to monitor the onset of diseases, such as osteoporosis.

  5. Multichannel analyzer embedded in FPGA

    International Nuclear Information System (INIS)

    Garcia D, A.; Hernandez D, V. M.; Vega C, H. R.; Ordaz G, O. O.; Bravo M, I.

    2017-10-01

    Ionizing radiation has different applications, so it is a very significant and useful tool, which in turn can be dangerous for living beings if they are exposed to uncontrolled doses. However, due to its characteristics, it cannot be perceived by any of the senses of the human being, so that in order to know the presence of it, radiation detectors and additional devices are required to quantify and classify it. A multichannel analyzer is responsible for separating the different pulse heights that are generated in the detectors, in a certain number of channels; according to the number of bits of the analog to digital converter. The objective of the work was to design and implement a multichannel analyzer and its associated virtual instrument, for nuclear spectrometry. The components of the multichannel analyzer were created in VHDL hardware description language and packaged in the Xilinx Vivado design suite, making use of resources such as the ARM processing core that the System on Chip Zynq contains and the virtual instrument was developed on the LabView programming graphics platform. The first phase was to design the hardware architecture to be embedded in the FPGA and for the internal control of the multichannel analyzer the application was generated for the ARM processor in C language. For the second phase, the virtual instrument was developed for the management, control and visualization of the results. The data obtained as a result of the development of the system were observed graphically in a histogram showing the spectrum measured. The design of the multichannel analyzer embedded in FPGA was tested with two different radiation detection systems (hyper-pure germanium and scintillation) which allowed determining that the spectra obtained are similar in comparison with the commercial multichannel analyzers. (Author)

  6. Analyzing Generation Y Workforce Motivation

    Science.gov (United States)

    2011-03-01

    Analyzing Generation Y Workforce Motivation Ian N. Barford n Patrick T. Hester R Defense AT&L: Special Edition: March –April 2011 36 Report...REPORT TYPE 3. DATES COVERED 00-00-2011 to 00-00-2011 4. TITLE AND SUBTITLE Analyzing Generation Y Workforce Motivation 5a. CONTRACT NUMBER 5b...between 1965 and 1979), and Generation Y (born between 1980 and 2000). 37 Defense AT&L: Special Edition: March –April 2011 Defense AT&L: Special

  7. Analyzing and forecasting the European social climate

    Directory of Open Access Journals (Sweden)

    Liliana DUGULEANĂ

    2015-06-01

    Full Text Available The paper uses the results of the sample survey Eurobarometer, which has been requested by the European Commission. The social climate index is used to measure the level of perceptions of population by taking into account their personal situation and their perspective at national level. The paper makes an analysis of the evolution of social climate indices for the countries of European Union and offers information about the expectations of population of analyzed countries. The obtained results can be compared with the forecasting of Eurobarometer, on short term of one year and medium term of five years. Modelling the social climate index and its influence factors offers useful information about the efficiency of social protection and inclusion policies.

  8. Policy Innovation in Innovation Policy

    DEFF Research Database (Denmark)

    Borras, Susana

    as with national and sub-national governments in Europe, all of them introducing interesting novelties in their innovation policy. These changes refer to different aspects of policy, mainly the content of policy initiatives towards science, technology and innovation; the instruments governments are using...... to achieve their goals; and the actors in the policy system that are being mobilised in pursuing these goals. This paper deals with these policy changes, paying special attention to the novelties introduced since the early 1990s in Europe. The perspective of this paper deals mainly on the changes introduced...... at the EU level, and mentions similar trends taking place at national and sub-national levels. The questions that guide the contents here are essentially three, namely, what are the main traits of innovation policies in Europe since the 1990s and how have the EU and different national governments approached...

  9. The security analyzer: A security analyzer program written in Prolog

    International Nuclear Information System (INIS)

    Zimmerman, B.D.; Densley, P.J.

    1986-09-01

    The Security Analyzer is a software tool capable of analyzing the effectiveness of a facility's security system. It is written in the Prolog logic programming computer language, using entity-relationship data modeling techniques. The program performs the following functions: (1) provides descriptive, locational and operational status information about intrusion detectors and assessment devices (i.e., ''sensors'' and ''cameras'') upon request; (2) provides for storage and retrieval of maintenance history information for various components of the security system (including intrusion detectors), and allows for changing that information as desired; (3) provides a ''search'' mode, wherein all paths are found from any specified physical location to another specified location which satisfy user chosen ''intruder detection'' probability and elapsed time criteria (i.e., the program finds the ''weakest paths'' from a security point of view). The first two of these functions can be provided fairly easily with a conventional database program; the third function could be provided using Fortran or some similar language, though with substantial difficulty. In the Security Analyzer program, all these functions are provided in a simple and straight-forward manner. This simplicity is possible because the program is written in the symbolic (as opposed to numeric) processing language Prolog, and because the knowledge base is structured according to entity-relationship modeling principles. Also, the use of Prolog and the entity-relationship modeling technique allows the capabilities of the Security analyzer program, both for knowledge base interrogation and for searching-type operations, to be easily expanded in ways that would be very difficult for a numeric and more algorithmically deterministic language such as Fortran to duplicate. 4 refs

  10. Historical Thinking: Analyzing Student and Teacher Ability to Analyze Sources

    OpenAIRE

    Cowgill II, Daniel Armond; Waring, Scott M.

    2017-01-01

    The purpose of this study was to partially replicate the Historical Problem Solving: A Study of the Cognitive Process Using Historical Evidence study conducted by Sam Wineburg in 1991. The Historical Problem Solving study conducted by Wineburg (1991) sought to compare the ability of historians and top level students, as they analyzed pictures and written documents centered on the Battle of Lexington Green. In this version of the study, rather than compare historians and students, we sought ...

  11. Pollution Analyzing and Monitoring Instruments.

    Science.gov (United States)

    1972

    Compiled in this book is basic, technical information useful in a systems approach to pollution control. Descriptions and specifications are given of what is available in ready made, on-the-line commercial equipment for sampling, monitoring, measuring and continuously analyzing the multitudinous types of pollutants found in the air, water, soil,…

  12. Methods of analyzing crude oil

    Energy Technology Data Exchange (ETDEWEB)

    Cooks, Robert Graham; Jjunju, Fred Paul Mark; Li, Anyin; Rogan, Iman S.

    2017-08-15

    The invention generally relates to methods of analyzing crude oil. In certain embodiments, methods of the invention involve obtaining a crude oil sample, and subjecting the crude oil sample to mass spectrometry analysis. In certain embodiments, the method is performed without any sample pre-purification steps.

  13. Analyzing Software Piracy in Education.

    Science.gov (United States)

    Lesisko, Lee James

    This study analyzes the controversy of software piracy in education. It begins with a real world scenario that presents the setting and context of the problem. The legalities and background of software piracy are explained and true court cases are briefly examined. Discussion then focuses on explaining why individuals and organizations pirate…

  14. The Convertible Arbitrage Strategy Analyzed

    NARCIS (Netherlands)

    Loncarski, I.; Ter Horst, J.R.; Veld, C.H.

    2006-01-01

    This paper analyzes convertible bond arbitrage on the Canadian market for the period 1998 to 2004.Convertible bond arbitrage is the combination of a long position in convertible bonds and a short position in the underlying stocks. Convertible arbitrage has been one of the most successful strategies

  15. La coactivación del bíceps femoral limita la fuerza máxima isométrica de extensión de rodilla en ciclistas de ruta

    OpenAIRE

    García-López, David; Bresciani, Guilherme; Cabeza de Vaca, Salvador; Garatachea, Nuria; De Paz, José

    2006-01-01

    Introducción y objetivos: El objeto del presente estudio fue analizar la coactivación antagonista (bíceps femoral) durante una contracción máxima isométrica de extensión unilateral de rodilla, en ciclistas de ruta, así como su relación con la activación agonista (recto femoral, vasto medial y vasto lateral) y la fuerza manifestada. La activación de los músculos gastrocnemios también fue monitorizada. Métodos: Dieciséis ciclistas federados efectuaron una prueba máxima de extensión isométr...

  16. Informed policies

    International Development Research Centre (IDRC) Digital Library (Canada)

    cation technology (ICT) and now. Minister of Science and Technology, was one of the architects of Mozam- bique's ICT policy in 2000 — the first in Africa. Nationwide access to these technologies is one of the pillars of the government's science and technology policy. “We don't believe in politicians, but we believe in politics.

  17. Analyzer for gamma cameras diagnostic

    International Nuclear Information System (INIS)

    Oramas Polo, I.; Osorio Deliz, J. F.; Diaz Garcia, A.

    2013-01-01

    This research work was carried out to develop an analyzer for gamma cameras diagnostic. It is composed of an electronic system that includes hardware and software capabilities, and operates from the acquisition of the 4 head position signals of a gamma camera detector. The result is the spectrum of the energy delivered by nuclear radiation coming from the camera detector head. This system includes analog processing of position signals from the camera, digitization and the subsequent processing of the energy signal in a multichannel analyzer, sending data to a computer via a standard USB port and processing of data in a personal computer to obtain the final histogram. The circuits are composed of an analog processing board and a universal kit with micro controller and programmable gate array. (Author)

  18. New approach to analyzing vulnerability

    International Nuclear Information System (INIS)

    O'Callaghan, P.B.; Carlson, R.L.; Riedeman, G.W.

    1986-01-01

    The Westinghouse Hanford Company (WHC) has recently completed construction of the Fuel Cycle Plant (FCP) at Richland, Washington. At start-up the facility will fabricate driver fuel for the Fast Flux Test Facility in the Secure Automated Fabrication line. After construction completion, but before facility certification, the Department of Energy (DOE) Richland Operation Office requested that a vulnerability analysis be performed which assumed multiple insiders as a threat to the security system. A unique method of analyzing facility vulnerabilities was developed at the Security Applications Center (SAC), which is managed by WHC for DOE. The method that was developed verifies a previous vulnerability assessment, as well as introducing a modeling technique which analyzes security alarms in relation to delaying factors and possible insider activities. With this information it is possible to assess the relative strength or weakness of various possible routes to and from a target within a facility

  19. Methods for Analyzing Social Media

    DEFF Research Database (Denmark)

    Jensen, Jakob Linaa

    2013-01-01

    Social media is becoming increasingly attractive for users. It is a fast way to communicate ideas and a key source of information. It is therefore one of the most influential mediums of communication of our time and an important area for audience research. The growth of social media invites many...... new questions such as: How can we analyze social media? Can we use traditional audience research methods and apply them to online content? Which new research strategies have been developed? Which ethical research issues and controversies do we have to pay attention to? This book focuses on research...... strategies and methods for analyzing social media and will be of interest to researchers and practitioners using social media, as well as those wanting to keep up to date with the subject....

  20. Space Politics and Policy: An Evolutionary Perspective

    Science.gov (United States)

    Sadeh, Eligar

    2002-01-01

    This paper offers an evolutionary perspective of space policy. It is argued that (1) space policy is evolutionary in that it has responded to dramatic political events, such as the launching of Sputnik and the Cold War, and has undergone dynamic and evolutionary policy changes over the course of the past fifty years of the space-age; and that (2) space policy is an integral part of and interacts with public policy processes in the United States and abroad. To this end, the paper analyzes space policy at several levels of analysis. This includes: (1) historical context, political actors and institutions, political processes, and policy outcomes; (2) the symbiotic relationships between policy and space technology; and (3) future space policy trends and developments likely to occur in the 21st century. A "Space Politics and Policy Framework" is developed in this paper to represent the evolution of space policy. Space policy involves both the process of policy formation and policy change over time (e.g., emergence of commercialization) and the courses of action taken to achieve political (and technological) determined outcomes. The evolution of space policy over time takes place through policy change. On this basis, public policy processes over the course of the space-age have involved the mobilization of governmental resources, actors, and institutions. Concomitantly, nongovernmental actors, such as private corporations and commercial enterprises, increasingly play a role in space. As a result, market factors in addition to political forces influence space policy.

  1. Portable Tandem Mass Spectrometer Analyzer

    Science.gov (United States)

    1991-07-01

    FILE : MHCI TUNE TABLE 84 (SCANNING with PARENT) SCAN RANGE 10.9 TO 700.0 TUNE MASS 355.0 (AUTO) >LENS 1-3 -13. 88 0. 2: POFF - 1. 2 9: COFF - 4. 1 3...and 500 ng of caffeine in I uL of chloroform by GC/A?:,,MS using negative ions. Also analyzed were barbiturates, extracted from urine, in the 3-5 Mg

  2. Remote Laser Diffraction PSD Analyzer

    Energy Technology Data Exchange (ETDEWEB)

    Batcheller, Thomas Aquinas; Huestis, Gary Michael; Bolton, Steven Michael

    2000-06-01

    Particle size distribution (PSD) analysis of radioactive slurry samples were obtained using a modified "off-the-shelf" classical laser light scattering particle size analyzer. A Horiba Instruments Inc. Model La-300 PSD analyzer, which has a 0.1 to 600 micron measurement range, was modified for remote application in a "hot cell" (gamma radiation) environment. The general details of the modifications to this analyzer are presented in this paper. This technology provides rapid and simple PSD analysis, especially down in the fine and microscopic particle size regime. Particle size analysis of these radioactive slurries down in this smaller range was not achievable - making this technology far superior than the traditional methods used previously. Remote deployment and utilization of this technology is in an exploratory stage. The risk of malfunction in this radiation environment is countered by gaining of this tremendously useful fundamental engineering data. Successful acquisition of this data, in conjunction with other characterization analyses, provides important information that can be used in the myriad of potential radioactive waste management alternatives.

  3. Remote Laser Diffraction PSD Analyzer

    International Nuclear Information System (INIS)

    Batcheller, Thomas Aquinas; Huestis, Gary Michael; Bolton, Steven Michael

    2000-01-01

    Particle size distribution (PSD) analysis of radioactive slurry samples were obtained using a modified ''off-the-shelf'' classical laser light scattering particle size analyzer. A Horiba Instruments Inc. Model La-300 PSD analyzer, which has a 0.1 to 600 micron measurement range, was modified for remote application in a ''hot cell'' (gamma radiation) environment. The general details of the modifications to this analyzer are presented in this paper. This technology provides rapid and simple PSD analysis, especially down in the fine and microscopic particle size regime. Particle size analysis of these radioactive slurries down in this smaller range was not achievable--making this technology far superior than the traditional methods used previously. Remote deployment and utilization of this technology is in an exploratory stage. The risk of malfunction in this radiation environment is countered by gaining of this tremendously useful fundamental engineering data. Successful acquisition of this data, in conjunction with other characterization analyses, provides important information that can be used in the myriad of potential radioactive waste management alternatives

  4. Sulfur Dioxide Analyzer Instrument Handbook

    Energy Technology Data Exchange (ETDEWEB)

    Springston, Stephen R. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2016-05-01

    The Sulfur Dioxide Analyzer measures sulfur dioxide based on absorbance of UV light at one wavelength by SO2 molecules which then decay to a lower energy state by emitting UV light at a longer wavelength. Specifically, SO2 + hυ1 →SO2 *→SO2 + hυ2 The emitted light is proportional to the concentration of SO2 in the optical cell. External communication with the analyzer is available through an Ethernet port configured through the instrument network of the AOS systems. The Model 43i-TLE is part of the i-series of Thermo Scientific instruments. The i-series instruments are designed to interface with external computers through the proprietary Thermo Scientific iPort Software. However, this software is somewhat cumbersome and inflexible. Brookhaven National Laboratory (BNL) has written an interface program in National Instruments LabView that both controls the Model 43i-TLE Analyzer AND queries the unit for all measurement and housekeeping data. The LabView vi (the software program written by BNL) ingests all raw data from the instrument and outputs raw data files in a uniform data format similar to other instruments in the AOS and described more fully in Section 6.0 below.

  5. Remote Laser Diffraction PSD Analyzer

    International Nuclear Information System (INIS)

    Batcheller, T.A.; Huestis, G.M.; Bolton, S.M.

    2000-01-01

    Particle size distribution (PSD) analysis of radioactive slurry samples were obtained using a modified off-the-shelf classical laser light scattering particle size analyzer. A Horiba Instruments Inc. Model La-300 PSD analyzer, which has a 0.1 to 600 micron measurement range, was modified for remote application in a hot cell (gamma radiation) environment. The general details of the modifications to this analyzer are presented in this paper. This technology provides rapid and simple PSD analysis, especially down in the fine and microscopic particle size regime. Particle size analysis of these radioactive slurries down in this smaller range was not achievable - making this technology far superior than the traditional methods used previously. Remote deployment and utilization of this technology is in an exploratory stage. The risk of malfunction in this radiation environment is countered by gaining of this tremendously useful fundamental engineering data. Successful acquisition of this data, in conjunction with other characterization analyses, provides important information that can be used in the myriad of potential radioactive waste management alternatives

  6. Analyzing Big Data in Psychology: A Split/Analyze/Meta-Analyze Approach.

    Science.gov (United States)

    Cheung, Mike W-L; Jak, Suzanne

    2016-01-01

    Big data is a field that has traditionally been dominated by disciplines such as computer science and business, where mainly data-driven analyses have been performed. Psychology, a discipline in which a strong emphasis is placed on behavioral theories and empirical research, has the potential to contribute greatly to the big data movement. However, one challenge to psychologists-and probably the most crucial one-is that most researchers may not have the necessary programming and computational skills to analyze big data. In this study we argue that psychologists can also conduct big data research and that, rather than trying to acquire new programming and computational skills, they should focus on their strengths, such as performing psychometric analyses and testing theories using multivariate analyses to explain phenomena. We propose a split/analyze/meta-analyze approach that allows psychologists to easily analyze big data. Two real datasets are used to demonstrate the proposed procedures in R. A new research agenda related to the analysis of big data in psychology is outlined at the end of the study.

  7. Analyzing Big Data in Psychology: A Split/Analyze/Meta-Analyze Approach

    Science.gov (United States)

    Cheung, Mike W.-L.; Jak, Suzanne

    2016-01-01

    Big data is a field that has traditionally been dominated by disciplines such as computer science and business, where mainly data-driven analyses have been performed. Psychology, a discipline in which a strong emphasis is placed on behavioral theories and empirical research, has the potential to contribute greatly to the big data movement. However, one challenge to psychologists—and probably the most crucial one—is that most researchers may not have the necessary programming and computational skills to analyze big data. In this study we argue that psychologists can also conduct big data research and that, rather than trying to acquire new programming and computational skills, they should focus on their strengths, such as performing psychometric analyses and testing theories using multivariate analyses to explain phenomena. We propose a split/analyze/meta-analyze approach that allows psychologists to easily analyze big data. Two real datasets are used to demonstrate the proposed procedures in R. A new research agenda related to the analysis of big data in psychology is outlined at the end of the study. PMID:27242639

  8. Analyzing Big Data in Psychology: A Split/Analyze/Meta-Analyze Approach

    Directory of Open Access Journals (Sweden)

    Mike W.-L. Cheung

    2016-05-01

    Full Text Available Big data is a field that has traditionally been dominated by disciplines such as computer science and business, where mainly data-driven analyses have been performed. Psychology, a discipline in which a strong emphasis is placed on behavioral theories and empirical research, has the potential to contribute greatly to the big data movement. However, one challenge to psychologists – and probably the most crucial one – is that most researchers may not have the necessary programming and computational skills to analyze big data. In this study we argue that psychologists can also conduct big data research and that, rather than trying to acquire new programming and computational skills, they should focus on their strengths, such as performing psychometric analyses and testing theories using multivariate analyses to explain phenomena. We propose a split/analyze/meta-analyze approach that allows psychologists to easily analyze big data. Two real datasets are used to demonstrate the proposed procedures in R. A new research agenda related to the analysis of big data in psychology is outlined at the end of the study.

  9. Solving the Policy Implementation Problem

    Directory of Open Access Journals (Sweden)

    Gregg A. Garn

    1999-08-01

    Full Text Available When Republican legislators in Arizona failed to approve educational vouchers in four consecutive legislative sessions, a charter school program was approved as a compromise. The charter school policy was written during a special summer session and within three years, over 30,000 students were enrolled in 260 charter schools across the state. Republican policy makers, who failed to enact voucher legislation, proclaimed the charter school program to be an overwhelming success and protected it from amendments by Democrats and potential actions of bureaucrats that could have altered the policy intent. Research on the implementation of policy indicates that state and local implementors frequently undermine or alter legislative intentions. However, when Arizona policy makers approved the charter school policy, they overcame this persistent implementation phenomenon and, in fact, succeeded in preserving the legislative intentions in the working program. This policy study analyzes how they were able to achieve this elusive result. Key policy makers attended to four significant features of policy implementation in creating the charter school policy: communication, financial resources, implementor attitudes, and bureaucratic structure. Manipulating these key variables allowed policy makers to reduce implementation slippage.

  10. Policy stories

    DEFF Research Database (Denmark)

    Ren, Carina Bregnholm; Rasmussen, Rasmus Kjærgaard

    planning and execution and of event outcomes beyond the narrow confines of bed nights and legacies. Second, we introduce policies as an entry point to unlock discussions and manifestations of value and futures which connect to AWG. In order to exemplify the workings of the AWG event in these domains, we...... present three central policy stories from the field. The stories tell of how the event was first interested, then activated and finally evaluated. Besides adding a new understanding to policy-driven events as a locus of value creation, we also argue that the AWG 2016 offer speculative bets for new...

  11. Analyzing the efficacy of subtropical urban forests in offsetting carbon emissions from cities

    Science.gov (United States)

    Francisco Escobedo; Sebastian Varela; Min Zhao; John E. Wagner; Wayne Zipperer

    2010-01-01

    Urban forest management and policies have been promoted as a tool to mitigate carbon dioxide (CO2) emissions. This study used existing CO2 reduction measures from subtropical Miami-Dade and Gainesville, USA and modeled carbon storage and sequestration by trees to analyze policies that use urban forests to offset carbon emissions. Field data were analyzed, modeled, and...

  12. New Approaches for Monetary Policy

    Directory of Open Access Journals (Sweden)

    Alexandra ADAM

    2012-02-01

    Full Text Available As a result of the economic turmoil started in 2007, there is a dispute if the monetary policy implies radical changes or just a rethinking of details regarding the main framework of the monetary policy strategy. Therefore, the actual debates that I have analyzed in the article take into account, among others, the relationship of monetary policy with the one of financial stability, the analyze if the monetary policy should lean against credit bubbles or just clean after their explosion (Lean vs. Clean debate, the presence of nonlinearities in economy. Thus, monetary economy becomes more interesting and the economists need to think about a wider range of monetary policy problems than existed before.

  13. Charged particle mobility refrigerant analyzer

    Science.gov (United States)

    Allman, S.L.; Chunghsuan Chen; Chen, F.C.

    1993-02-02

    A method for analyzing a gaseous electronegative species comprises the steps of providing an analysis chamber; providing an electric field of known potential within the analysis chamber; admitting into the analysis chamber a gaseous sample containing the gaseous electronegative species; providing a pulse of free electrons within the electric field so that the pulse of free electrons interacts with the gaseous electronegative species so that a swarm of electrically charged particles is produced within the electric field; and, measuring the mobility of the electrically charged particles within the electric field.

  14. Fuel analyzer; Analisador de combustiveis

    Energy Technology Data Exchange (ETDEWEB)

    Cozzolino, Roberval [RS Motors, Indaiatuba, SP (Brazil)

    2008-07-01

    The current technology 'COMBUSTIMETRO' aims to examine the fuel through performance of the engine, as the role of the fuel is to produce energy for the combustion engine in the form of which is directly proportional to the quality and type of fuel. The 'COMBUSTIMETRO' has an engine that always keeps the same entry of air, fuel and fixed point of ignition. His operation is monitored by sensors (Sonda Lambda, RPM and Gases Analyzer) connected to a processor that performs calculations and records the information, generate reports and graphs. (author)

  15. The role of policy for documentary systems

    Directory of Open Access Journals (Sweden)

    Maria Mata Caravaca

    2015-05-01

    Full Text Available The article analyzes the role that policies have in guaranteeing the quality of creation, management and maintenance of digital resources, and offers an overview of national and international policies and standards that refer to records management and digital preservation. Finally, the article illustrates ICCROM’s records management manual and its digital preservation policy and strategy.

  16. Reagan's Foreign Policy: An Assessment (I) Introduction.

    Science.gov (United States)

    Johnston, Whittle

    1990-01-01

    Examines the relationship between former U.S. President Ronald Reagan's foreign policy and those of his predecessors. Focuses on the differences between Reagan's policies and those of former U.S. President Jimmy Carter. Analyzes Reagan's policies of containment, human rights, and arms control. Discusses criticisms launched against Reagan's…

  17. Historical Thinking: Analyzing Student and Teacher Ability to Analyze Sources

    Directory of Open Access Journals (Sweden)

    Daniel Armond Cowgill II

    2017-05-01

    Full Text Available The purpose of this study was to partially replicate the Historical Problem Solving: A Study of the Cognitive Process Using Historical Evidence study conducted by Sam Wineburg in 1991. The Historical Problem Solving study conducted by Wineburg (1991 sought to compare the ability of historians and top level students, as they analyzed pictures and written documents centered on the Battle of Lexington Green. In this version of the study, rather than compare historians and students, we sought out to compare the analytical skills of teachers and students. The main findings relate to the fact that the participants lacked the ability to engage in the very complex activities associated with historical inquiry and the utilization of primary sources in learning about the past. This lack of ability should be used to improve teacher professional development programs and help them develop the skills needed to not only engage in historical evaluation themselves but to also develop skills that will allow them to instruct students to do the same.

  18. Compact Microwave Fourier Spectrum Analyzer

    Science.gov (United States)

    Savchenkov, Anatoliy; Matsko, Andrey; Strekalov, Dmitry

    2009-01-01

    A compact photonic microwave Fourier spectrum analyzer [a Fourier-transform microwave spectrometer, (FTMWS)] with no moving parts has been proposed for use in remote sensing of weak, natural microwave emissions from the surfaces and atmospheres of planets to enable remote analysis and determination of chemical composition and abundances of critical molecular constituents in space. The instrument is based on a Bessel beam (light modes with non-zero angular momenta) fiber-optic elements. It features low power consumption, low mass, and high resolution, without a need for any cryogenics, beyond what is achievable by the current state-of-the-art in space instruments. The instrument can also be used in a wide-band scatterometer mode in active radar systems.

  19. Analyzing mass perceptions of nuclear politics: Puzzling over trust

    International Nuclear Information System (INIS)

    Jenkins-Smith, H.C.; Pratt, D.A.; Bassett, G.W. Jr.

    1994-01-01

    The juxtaposition of public values, trust, and beliefs is at the core of policy-making in democratic political systems, and an accurate understanding of nuclear politics requires that researchers untangle and carefully think about the web of psychological and social influences that shape citizens' preferences. In this paper, we offer some tentative answers about several pieces of the trust open-quotes puzzleclose quotes. First, we reconsider what is meant by open-quotes trustclose quotes and how it is to be measured. We then use telephone survey data to explore the relationship between trust and citizens' nuclear policy preferences. The data lend support to the conclusion that trust is more mutable than previous research has shown, and besides the traditional measure of competence includes aspects of believability and fiduciary competence. The data further indicate that it is a mistake to think in terms of a single open-quotes publicclose quotes when exploring the link between trust and nuclear policies. A number of dissimilar open-quotes publicsclose quotes based on shared open-quotes worldviewsclose quotes or political cultures are apparent in the data analyzed here. These open-quotes publicsclose quotes appear to think about trust differently from one another and rely on different dimensions of trust when determining nuclear policy preferences. Policy-makers must recognize the different open-quotes publicsclose quotes coexisting within the U.S. nuclear policy arena, and the relative import that these publics place on different dimensions of trust

  20. A Study on the Nuclear Technology Policy

    Energy Technology Data Exchange (ETDEWEB)

    Oh, K. B.; Lee, K. S.; Chung, W. S.; Lee, T. J.; Yun, S. W.; Jeong, I.; Lee, J. H

    2007-02-15

    The objective of the study was to make policy-proposals for enhancing the effectiveness and efficiency of national nuclear technology R and D programs. To do this, environmental changes of international nuclear energy policy and trends of nuclear technology development were surveyed and analyzed. This Study analyzed trends of nuclear technology policies and developed the nuclear energy R and D innovation strategy in a viewpoint of analyzing the changes in the global policy environment associated with nuclear technology development and development of national nuclear R and D strategy.

  1. Radiation energy detector and analyzer

    International Nuclear Information System (INIS)

    Roberts, T.G.

    1981-01-01

    A radiation detector array and a method for measuring the spectral content of radiation. The radiation sensor or detector is an array or stack of thin solid-electrolyte batteries. The batteries, arranged in a stack, may be composed of independent battery cells or may be arranged so that adjacent cells share a common terminal surface. This common surface is possible since the polarity of the batteries with respect to an adjacent battery is unrestricted, allowing a reduction in component parts of the assembly and reducing the overall stack length. Additionally, a test jig or chamber for allowing rapid measurement of the voltage across each battery is disclosed. A multichannel recorder and display may be used to indicate the voltage gradient change across the cells, or a small computer may be used for rapidly converting these voltage readings to a graph of radiation intensity versus wavelength or energy. The behavior of the batteries when used as a radiation detector and analyzer are such that the voltage measurements can be made at leisure after the detector array has been exposed to the radiation, and it is not necessary to make rapid measurements as is now done

  2. Thomson parabola ion energy analyzer

    Energy Technology Data Exchange (ETDEWEB)

    Cobble, James A [Los Alamos National Laboratory; Flippo, Kirk A [Los Alamos National Laboratory; Letzring, Samuel A [Los Alamos National Laboratory; Lopez, Frank E [Los Alamos National Laboratory; Offermann, Dustin T [Los Alamos National Laboratory; Oertel, John A [Los Alamos National Laboratory; Mastrosimone, Dino [UNIV OF ROCHESTER

    2010-01-01

    A new, versatile Thomson parabola ion energy (TPIE) analyzer has been designed and constructed for use at the OMEGA-EP facility. Multi-MeV ions from EP targets are transmitted through a W pinhole into a (5- or 8-kG) magnetic field and subsequently through a parallel electric field of up to 30 kV/cm. The ion drift region may have a user-selected length of 10, 50, or 80 cm. With the highest fields, 500-Me V C{sup 6+} and C{sup 5+} may be resolved. TPIE is TIM-mounted at OMEGA-EP and is qualified in all existing TIMs. The instrument runs on pressure-interlocked 15-VDC power available in EP TIM carts. It may be inserted to within several inches of the target to attain sufficient flux for a measurement. For additional flux control, the user may select a square-aperture W pinhole of 0.004-inch or 0.010-inch. The detector consists of CR-39 backed by an image plate. The fully relativistic design code and design features are discussed. Ion spectral results from first use at OMEGA-EP are expected.

  3. Nuclear plant analyzer desktop workstation

    International Nuclear Information System (INIS)

    Beelman, R.J.

    1990-01-01

    In 1983 the U.S. Nuclear Regulatory Commission (USNRC) commissioned the Idaho National Engineering Laboratory (INEL) to develop a Nuclear Plant Analyzer (NPA). The NPA was envisioned as a graphical aid to assist reactor safety analysts in comprehending the results of thermal-hydraulic code calculations. The development was to proceed in three distinct phases culminating in a desktop reactor safety workstation. The desktop NPA is now complete. The desktop NPA is a microcomputer based reactor transient simulation, visualization and analysis tool developed at INEL to assist an analyst in evaluating the transient behavior of nuclear power plants by means of graphic displays. The NPA desktop workstation integrates advanced reactor simulation codes with online computer graphics allowing reactor plant transient simulation and graphical presentation of results. The graphics software, written exclusively in ANSI standard C and FORTRAN 77 and implemented over the UNIX/X-windows operating environment, is modular and is designed to interface to the NRC's suite of advanced thermal-hydraulic codes to the extent allowed by that code. Currently, full, interactive, desktop NPA capabilities are realized only with RELAP5

  4. Endogenous Environmental Policy when Pollution is Transboundary

    OpenAIRE

    Joachim Fünfgelt; Günther G. Schulze

    2011-01-01

    We analyze the formation of environmental policy to regulate transboundary pollution if governments are self-interested. In a common agency framework, we portray the environmental policy calculus of two political supportmaximizing governments that are in a situation of strategic interaction with respect to their environmental policies, but too small to affect world market prices. We show how governments systematically deviate from socially optimal environmental policies. Taxes may be too high...

  5. Business interest in Swiss climate policy

    OpenAIRE

    Börner, Alexandra

    2009-01-01

    Business associations play an important role in the decision making process of climate policy. In 2009, the revision of the Swiss CO2 law for designing post‐2012 climate policy is at stake. This paper analyzes the positions and arguments of the Swiss business community on climate policy using cluster analysis. As a main finding, we can observe gradual positioning between opponents and proponents to climate regulation. There is no solid business front opposing climate policy in Switzerland but...

  6. Policy Reader

    International Nuclear Information System (INIS)

    1985-09-01

    This policy reader comprises: Correspondence; Memorandum of Understanding between the US Department of Transportation and the US Department of Energy for the Transportation of Radioactive Materials under the Nuclear Waste Policy Act; Internal Guidelines for Interactions with Communities and Local Governments; Statement by Ben C. Rusche before the Committee on Interior and Insular Affairs, Subcommittee on Energy and the Environment, US House of Representatives, September 13, 1985; Speech presented by Ben C. Rusche before the ANS/CNS/AESJ/ENS Topical Meeting, Pasco, Washington, September 24, 1985 - ''Status of the United States' High-Level Nuclear Waste Disposal Program''; and ''DOE Seeks Comments on Nuclear Transportation Planning,'' DOE News, September 30, 1985

  7. Population policy.

    Science.gov (United States)

    1987-03-01

    Participants in the Seminar on Population Policies for Top-level Policy Makers and Program Managers, meeting in Thailand during January 1987, examined the challenges now facing them regarding the implementation of fertility regulation programs in their respective countries -- Bangladesh, China, India, Indonesia, Malaysia, Nepal, Pakistan, the Philippines, the Republic of Korea, and Thailand. This Seminar was organized to coincide with the completion of an Economic and Social Commission for Asia and the Pacific (ESCAP) study investigating the impact and efficiency of family planning programs in the region. Country studies were reviewed at the Seminar along with policy issues about the status of women, incentive and disincentive programs, and socioeconomic factors affecting fertility. In Bangladesh the government recognizes population growth as its top priority problem related to the socioeconomic development of the country and is working to promote a reorientation strategy from the previous clinic-oriented to a multidimensional family welfare program. China's family planning program seeks to postpone marraige, space the births of children between 3-5 years, and promote the 1-child family. Its goal is to reduce the rate of natural increase from 12/1000 in 1978 to 5/1000 by 1985 and 0 by 2000. India's 7th Five-Year-Plan (1986-90) calls for establishing a 2-child family norm by 2000. In Indonesia the government's population policy includes reducing the rate of population growth, achieving a redistribution of the population, adjusting economic factors, and creating prosperous families. The government of Indonesia reversed its policy to reduce the population growth rate in 1984 and announced its goal of achieving a population of 70 million by 2100 in order to support mass consumption industries. It has created an income tax deduction system favoring large families and maternity benefits for women who have up to 5 children as incentives. Nepal's official policy is to

  8. Language Policy

    DEFF Research Database (Denmark)

    Lauridsen, Karen M.

    2008-01-01

    Like any other text, instructive texts function within a given cultural and situational setting and may only be available in one language. However, the end users may not be familiar with that language and therefore unable to read and understand the instructions. This article therefore argues...... that instructive texts should always be available in a language that is understood by the end users, and that a corporate communication policy which includes a language policy should ensure that this is in fact the case for all instructive texts....

  9. Análise eletromiográfica do quadríceps durante a extensão do joelho em diferentes velocidades Electromyographical analysis of the quadriceps during knee extension at different speeds

    Directory of Open Access Journals (Sweden)

    Daniel Cury Ribeiro

    2005-01-01

    Full Text Available A síndrome de dor fêmuro-patelar (SDFP é uma disfunção comum, geralmente causada por trações laterais excessivas da patela. Indivíduos com SDFP, usualmente apresentam inibição do vasto medial oblíquo (VMO, o qual é responsável pela tração medial patelar. O tratamento conservador envolve o reforço do quadríceps para promover melhor estabilidade e tração patelar. Muitos pesquisadores buscam o recrutamento seletivo do VMO, com o intuito de otimizar o tratamento. O objetivo deste estudo é investigar, através da eletromiografia, a interferência da velocidade angular e diferentes formas de fixação do tubo elástico na atividade quadricipital. Dez indivíduos do sexo masculino com ausência de lesão muscular ou articular participaram deste estudo. Indivíduos com ângulo Q fora do intervalo de 10-15° foram excluídos da pesquisa. O tubo elástico foi fixado paralelo e oblíquo em relação ao corpo do indivíduo. As extensões de joelho foram realizadas com velocidades angulares de 60 e 120°/seg. Nenhuma atividade seletiva do VMO foi encontrada. Comparando os níveis de atividade muscular, durante as duas velocidades angulares houve aumento no nível de atividade eletromiográfica em todas porções do quadríceps, apenas para a fixação do tubo elástico paralela. Os resultados sugerem uma atividade sinérgica entre o VMO e as outras porções do quadríceps.The patellofemoral pain syndrome (PFPS is a common disorder of the knee; it's often caused by an excessive lateral traction of the patella. Subjects with this syndrome usually present a disruption in the activation of Vastus Mediallis Obliquus (VMO, which provides the patellar medial pull. Non-operative treatment includes quadriceps strengthening in order to promote better patellar stability and traction. Many researchers have been trying to selectively recruit the VMO, in order to improve treatments. The main purpose of this study is to investigate, using

  10. Evaluation and Policy Analysis: A Communicative Framework

    Directory of Open Access Journals (Sweden)

    Cynthia Wallat

    1997-07-01

    Full Text Available A major challenge for the next generation of students of human development is to help shape the paradigms by which we analyze and evaluate public policies for children and families. Advocates of building research and policy connections point to health care and stress experiences across home, school, and community as critical policy issues that expand the scope of contexts and outcomes studied. At a minimum, development researchers and practitioners will need to be well versed in available methods of inquiry; they will need to be "methodologically multilingual" when conducting evaluation and policy analysis, producing reports, and reporting their interpretations to consumer and policy audiences. This article suggests how traditional approaches to policy inquiry can be reconsidered in light of these research inquiry and communicative skills needed by all policy researchers. A fifteen year review of both policy and discourse processes research is presented to suggest ways to conduct policy studies within a communicative framework.

  11. AVALIAÇÃO DOS GÂNGLIOS REGIONAIS NO CARCINOMA EPIDERMÓIDE DO PÊNIS (CEP ATRAVÉS DE UM ÍNDICE DE RISCO

    Directory of Open Access Journals (Sweden)

    Cologna A. J.

    2001-01-01

    Full Text Available O objetivo desse estudo foi investigar a validade de um índice de risco (IR no prognóstico de metástases ganglionares no carcinoma epidermóide do pênis (CEP. Foram analisados 53 pacientes com CEP atendidos no Hospital das Clínicas da FMRP-USP, de janeiro de 1978 a dezembro de 1995. A idade variou de 32 a 97 anos. Os tumores foram graduados de acordo com a classificação de Broders e estadiados retrospectivamente (TNM 1999. O IR foi determinado pela soma de TeG (IR = T+G. A linfadenectomia inguinal bilateral (LD foi indicada naqueles que apresentaram gânglios suspeitos após a antibioticoterapia ou que vieram apresentar alterações durante o período de observação. Faleceram 17 pacientes; A LD foi realizada em 14 pacientes e os 39 restantes permaneceram em observação clínica, sendo que em 8 deles foi feito LD após tempo mediano de 9 meses. Dos pacientes com índice de risco 2 e 3 92% e 80% respectivamente não apresentavam metastase ganglionar, ao passo que a totalidade daqueles com IR=6 tinha gânglios comprometidos. A associação dos grupos 2 e 3, comparada ao conjunto 4, 5 e 6, mostrou percentual maior de comprometimento nestes últimos (p = 0,0046. Dos 36 pacientes inicialmente No, 27 apresentavam IR 2 ou 3, dos quais 5 evoluíram para N+ (19%; os 9 restantes eram IR > 4 e 3 também evoluíram para N+ (33%. Apesar da diferença, não houve significância estatística entre eles (p = 0,3837. Embora tenha ocorrido maior comprometimento naqueles com IR > 4, o índice de risco não foi capaz de identificar previamente pacientes que evoluíram para N+.

  12. Interactions between renewable energy policy and renewable energy industrial policy: A critical analysis of China's policy approach to renewable energies

    International Nuclear Information System (INIS)

    Zhang, Sufang; Andrews-Speed, Philip; Zhao, Xiaoli; He, Yongxiu

    2013-01-01

    This paper analyzes China's policy approach to renewable energies and assesses how effectively China has met the ideal of appropriate interactions between renewable energy policy and renewable energy industrial policy. First we briefly discuss the interactions between these two policies. Then we outline China's key renewable energy and renewable industrial policies and find that China's government has well recognized the need for this policy interaction. After that, we study the achievements and problems in China's wind and solar PV sector during 2005–2012 and argue that China's policy approach to renewable energies has placed priority first on developing a renewable energy manufacturing industry and only second on renewable energy itself, and it has not effectively met the ideal of appropriate interactions between renewable energy policy and renewable energy industrial policy. Lastly, we make an in-depth analysis of the three ideas underlying this policy approach, that is, the green development idea, the low-carbon leadership idea and indigenous innovation idea. We conclude that Chinas' policy approach to renewable energies needs to enhance the interactions between renewable energy policy and renewable energy industrial policy. The paper contributes to a deeper understanding of China's policy strategy toward renewable energies. -- Highlights: •Interactions between renewable energy policy and renewable energy industrial policy are discussed. •China's key renewable energy and renewable energy industrial policies are outlined. •Two empirical cases illustrate China's policy approach to renewable energies. •We argue that China needs to enhance the interactions between the two policies. •Three ideas underlie China's policy approach to renewable energies

  13. Monetary and Fiscal Policy Analysis: Which is More Effective?

    OpenAIRE

    Yunanto, Muhamad; Medyawati, Henny

    2014-01-01

    Fiscal policy is an adjustment in the income and expenditure of government as stipulated inthe state budget in order to achieve better economic stability and pace of development. Themain objective of this study was to measure and analyze Fiscal and Monetary Policy of theGross Domestic Product (GDP). Fiscal Policy Multiplier (FPM) and Monetary PolicyMultiplier (MPM) are used to answer the debate where more effective between fiscal policy andmonetary policy. Short-term models derived through er...

  14. X-ray crystal structures of the pheromone-binding domains of two quorum-hindered transcription factors, YenR of Yersinia enterocolitica and CepR2 of Burkholderia cenocepacia: KIM et al.

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Youngchang [Midwest Center for Structural Genomics, Biosciences, Argonne National Laboratory, Argonne Illinois 60439; Structural Biology Center, Biosciences, Argonne National Laboratory, Argonne Illinois 60439; Chhor, Gekleng [Midwest Center for Structural Genomics, Biosciences, Argonne National Laboratory, Argonne Illinois 60439; Tsai, Ching-Sung [Department of Microbiology, Cornell University, Ithaca New York 14853; Fox, Gabriel [Department of Microbiology, Cornell University, Ithaca New York 14853; Chen, Chia-Sui [Department of Microbiology, Cornell University, Ithaca New York 14853; Winans, Nathan J. [Department of Microbiology, Cornell University, Ithaca New York 14853; Jedrzejczak, Robert [Structural Biology Center, Biosciences, Argonne National Laboratory, Argonne Illinois 60439; Joachimiak, Andrzej [Midwest Center for Structural Genomics, Biosciences, Argonne National Laboratory, Argonne Illinois 60439; Structural Biology Center, Biosciences, Argonne National Laboratory, Argonne Illinois 60439; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago Illinois 60637; Winans, Stephen C. [Department of Microbiology, Cornell University, Ithaca New York 14853

    2017-07-24

    The ability of LuxR-type proteins to regulate transcription is controlled by bacterial pheromones, N-acylhomoserine lactones (AHLs). Most LuxR-family proteins require their cognate AHLs for activity, and some of them require AHLs for folding and stability, and for protease-resistance. However, a few members of this family are able to fold, dimerize, bind DNA, and regulate transcription in the absence of AHLs; moreover, these proteins are antagonized by their cognate AHLs. One such protein is YenR of Yersinia enterocolitica, which is antagonized by N-3-oxohexanoyl-l-homoserine lactone (OHHL). This pheromone is produced by the OHHL synthase, a product of the adjacent yenI gene. Another example is CepR2 of Burkholderia cenocepacia, which is antagonized by N-octanoyl-l-homoserine lactone (OHL), whose synthesis is directed by the cepI gene of the same bacterium. Here, we describe the high-resolution crystal structures of the AHL binding domains of YenR and CepR2. YenR was crystallized in the presence and absence of OHHL. While this ligand does not cause large scale changes in the YenR structure, it does alter the orientation of several highly conserved YenR residues within and near the pheromone-binding pocket, which in turn caused a significant movement of a surface-exposed loop.

  15. Evidence, Ethics & Social Policy Dilemmas

    Directory of Open Access Journals (Sweden)

    Steven I. Miller

    1993-07-01

    Full Text Available Within the philosophy of the social sciences, the relationship between evidence, ethics, and social policy is in need of further analysis. The present paper is an attempt to argue that while important social policies can, and perhaps ought to be, grounded in ethical theory, they are seldom articulated in this fashion due to the ambiguity surrounding the "evidence condition." Using a consequentialist-utilitarian framework, and a case study of a policy dilemma, the authors analyze the difficulties associated with resolving policy-based dilemmas which must appeal to evidential support as a justification for an ethical stand. Implication for the relevance of ethics to social policy formulation are discussed in detail.

  16. Innovation Policy in European Union

    Directory of Open Access Journals (Sweden)

    Marta-Christina Suciu

    2006-11-01

    Full Text Available The innovation policies aim to analyze priority factors shaping innovative performance and to reflect the increasing appreciation of the economic and social importance of innovation. This paper is commissioned to examine topics of current interest or concern to innovation policy-makers in Europe. Based on literature and the framework of the European Action Plan for Innovation, this paper investigates different levels and fields of European innovational systems and practices.

  17. A study on the nuclear technology policy

    International Nuclear Information System (INIS)

    Yang, Maeng Ho; Ham, C. H.; Kim, H. J.; Chung, W. S.; Lee, T. J.; Lee, B. O.; Yun, S. W.; Choi, Y. M.; Eom, T. Y.

    1998-01-01

    This study analyzed the major issues as the research activities for the support of establishment and implementation of national policy. The analyses were focused on the recommendations of the responsive direction of national policy in positive and effective manners in accordance with the changes of international nuclear affairs. This study also analyzed the creation of environmental foundation for effective implementation of the national policy and national R and D investment such as securing national consensus and openings of policy information to the public. The major results of the role and position of nuclear policy, trends of nuclear policy and nuclear R and D activities of USA, France, Japan, Asian developing countries etc. and international trends of small- and medium-sized reactor as well as spin-offs of nuclear R and D activities, were analyzed. (author). 66 refs., 27 tabs., 15 figs

  18. Flexibility-friendly support policies:

    DEFF Research Database (Denmark)

    Boscán Flores, Luis Rafael; Skytte, Klaus; Soysal, Emilie Rosenlund

    2017-01-01

    This paper introduces the concept of flexibilityfriendly support policies, i.e. state of-the-system-dependent subsidies given to producers of electricity who base their output on renewable energy sources (RES). Such policies increase with demand, decrease with the availability of Variable Renewable...... Energy (VRE) producers and, overall, follow the power system’s residual load. The paper presents a microeconomic framework to analyze this and other desirable properties of support mechanisms. To illustrate the concept, it uses the present-day policies of Nordic and Baltic countries (Denmark, Estonia......, Finland, Latvia, Lithuania, Sweden and Norway) as a case study....

  19. Women-friendly policy paradoxes?! Child Care policies and gender equality visions in Scandinavia

    DEFF Research Database (Denmark)

    Borchorst, Anette

    2006-01-01

    The chapter focuses on the political construction of the equality-difference dilemma in Scandinavian welfare policies. Different policy logics of childcare policies in Sweden, Norway and Denmark are addressed and the visions of gender equality underpinning them are analyzed....

  20. Antibiotic policy

    OpenAIRE

    Gyssens, Inge

    2011-01-01

    There is a clear association between antibiotic use and resistance both on individual and population levels. In the European Union, countries with large antibiotic consumption have higher resistance rates. Antibiotic resistance leads to failed treatments, prolonged hospitalisations, increased costs and deaths. With few new antibiotics in the Research & Development pipeline, prudent antibiotic use is the only option to delay the development of resistance. Antibiotic policy consists of prescrib...

  1. Internet Policy

    Science.gov (United States)

    Lehr, William H.; Pupillo, Lorenzo Maria

    The Internet is now widely regarded as essential infrastructure for our global economy and society. It is in our homes and businesses. We use it to communicate and socialize, for research, and as a platform for E-commerce. In the late 1990s, much was predicted about what the Internet has become at present; but now, we have actual experience living with the Internet as a critical component of our everyday lives. Although the Internet has already had profound effects, there is much we have yet to realize. The present volume represents a third installment in a collaborative effort to highlight the all-encompassing, multidisciplinary implications of the Internet for public policy. The first installment was conceived in 1998, when we initiated plans to organize an international conference among academic, industry, and government officials to discuss the growing policy agenda posed by the Internet. The conference was hosted by the European Commission in Brussels in 1999 and brought together a diverse mix of perspectives on what the pressing policy issues would be confronting the Internet. All of the concerns identified remain with us today, including how to address the Digital Divide, how to modify intellectual property laws to accommodate the new realities of the Internet, what to do about Internet governance and name-space management, and how to evolve broadcast and telecommunications regulatory frameworks for a converged world.

  2. Rethinking Plea Bargaining Policy: The Case of Ethiopia | Negash ...

    African Journals Online (AJOL)

    This article examines the desirability of plea bargaining in Ethiopia focusing on its policy justifications as encapsulated under the 2011 FRDE Criminal Justice Policy. Emphasizing upon the specific contexts of Ethiopia, the article analyzes policy documents, laws and comparative literature. The policy relies on the traditional ...

  3. From policy to reality

    DEFF Research Database (Denmark)

    Ditlevsen, Kia; Reventlow, Susanne; Nielsen, Annemette Ljungdalh

    2016-01-01

    visitors and which complicate implementation of the policies of the Danish health authorities. Findings show that the current system is not well equipped to treat early overweight. A gap in primary preventive health care for children at age 3–5, indistinct lines of responsibility, inadequate cooperation......, and lack of resources together make it difficult for health care professionals to initiate interventions and reach the children in need of support. By analyzing the policy implementation process in a theoretical framework that discloses the discursive allocation of responsibilities, the study is able...... to provide a deeper description and analysis of the problem. The study makes it clear how preventive health care for overweight children rests on the negotiation of formal and performed responsibilities among health practitioners within a framework of scarce resources and communication deficit....

  4. Antipodean Social Policy Responses to Economic Crises

    DEFF Research Database (Denmark)

    Starke, Peter

    2013-01-01

    In this article, I analyze the social policy reactions to economic crises in Australia and New Zealand. After the financial crisis of 2008, Australia built its crisis management strategy around a large fiscal stimulus with a significant social policy component, whereas New Zealand did not. While...... the government enacted fiscal stimulus measures, the social policy component was small and the government soon returned to welfare retrenchment and workfare policy. Based on a detailed account of recent crisis policies as well as a condensed overview of previous crisis responses (to the 1970s oil shocks...

  5. Population policies and development.

    Science.gov (United States)

    Stamper, B M

    1984-01-01

    This article critically examines 4 conceptual frameworks for Third World population policies: the family planning approach, beyond family planning measures, the development hypothesis and transition theory, and the distributive hypothesis and fertility. Although family planning is a basic human right and can lead to lower levels of population and improved maternal-child health, this approach alone does not always have a meaningful demographic impact. If high fertility is economically rational from the family viewpoint, the demand for family planning services will remain marginal. Other policies seek to go beyond the family planning approach and to directly influence the demand for reproductive control through provision of old age support, monetary incentives for reduced fertility or stringent and coercive measures. However, such policies can have adverse distributional effects and directly penalize the children of large families. The demographic transition theory lacks a measurable and specifiable causation mechanism, giving it little predictive value. It may be that economic growth increases fertility in the short run and reduces fertility only over the long run through indirect effects. The key issue is how the rate of growth is distributed across the population. The development and demographic transition hypothesis focuses mainly on aggregate economic and social measures rather than on their underlying distributions. The distributive hypothesis implies policies that promote a greater level of investment in human capital, with a wide distributional emphasis. Diffused investment in human capital is believed to indirectly influence the desire to control fertility. It is concluded that all 4 conceptual frameworks for analyzing fertility-related policies for the Third World are inadequate or seriously flawed. They are not pragmatic, do not identify or assign weights to the crucial causal variables, fail to specify thresholds or critical minimum levels, discount

  6. Improving adolescent health policy: incorporating a framework for assessing state-level policies.

    Science.gov (United States)

    Brindis, Claire D; Moore, Kristin

    2014-01-01

    Many US policies that affect health are made at the state, not the federal, level. Identifying state-level policies and data to analyze how different policies affect outcomes may help policy makers ascertain the usefulness of their public policies and funding decisions in improving the health of adolescent populations. A framework for describing and assessing the role of federal and state policies on adolescent health and well-being is proposed; an example of how the framework might be applied to the issue of teen childbearing is included. Such a framework can also help inform analyses of whether and how state and federal policies contribute to the variation across states in meeting adolescent health needs. A database on state policies, contextual variables, and health outcomes data can further enable researchers and policy makers to examine how these factors are associated with behaviors they aim to impact.

  7. Estimate of Cost-Effective Potential for Minimum Efficiency Performance Standards in 13 Major World Economies Energy Savings, Environmental and Financial Impacts

    Energy Technology Data Exchange (ETDEWEB)

    Letschert, Virginie E. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Bojda, Nicholas [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Ke, Jing [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); McNeil, Michael A. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2012-07-01

    This study analyzes the financial impacts on consumers of minimum efficiency performance standards (MEPS) for appliances that could be implemented in 13 major economies around the world. We use the Bottom-Up Energy Analysis System (BUENAS), developed at Lawrence Berkeley National Laboratory (LBNL), to analyze various appliance efficiency target levels to estimate the net present value (NPV) of policies designed to provide maximum energy savings while not penalizing consumers financially. These policies constitute what we call the “cost-effective potential” (CEP) scenario. The CEP scenario is designed to answer the question: How high can we raise the efficiency bar in mandatory programs while still saving consumers money?

  8. Control Structures and Payout Policy

    NARCIS (Netherlands)

    Renneboog, L.D.R.; Trojanowski, G.

    2005-01-01

    This paper examines the payout policies of UK firms listed on the London Stock Exchange during the 1990s.It complements the existing literature by analyzing the trends in both dividends and total payouts (including share repurchases).In a dynamic panel data regression setting, we relate target

  9. A Primer on Macroprudential Policy

    Science.gov (United States)

    Poutineau, Jean-Christophe; Vermandel, Gauthier

    2015-01-01

    This article introduces macroprudential policy using a static New Keynesian Macroeconomics model with financial frictions. The authors analyze two related questions: First, they show how the procyclicality of financial factors, captured by the financial accelerator, amplifies the transmission of supply and demand shocks and impacts the intuition…

  10. Fiscal policy under alternative monetary policy regimes

    OpenAIRE

    Diaz-Roldan; Carmelo Monteagudo-Cuerva

    2013-01-01

    In the particular policy framework of a monetary union, the management of fiscal policy becomes an issue of special relevance, because the fiscal discipline imposed by the monetary agreements could limit the scope of stabilization fiscal policies, and its implications on economic growth. Therefore, is not trivial to manage fiscal policy in such particular economic framework. In this paper we will review the implications of fiscal policy in open economies. But we will pay special attention to ...

  11. Celiac disease (CD, ulcerative colitis (UC, and primary sclerosing cholangitis (PSC in one patient: a family study Enfermedad celiaca (EC, colitis ulcerosa (CU y colangitis esclerosante primaria (CEP asociadas en el mismo paciente: estudio familiar

    Directory of Open Access Journals (Sweden)

    V. Cadahía

    2005-12-01

    Full Text Available We discuss the case of a 17-year-old male who at the age of 7 was diagnosed with celiac disease (CD together with ulcerative colitis (UC and primary sclerosing cholangitis (PSC. The patient was treated with gluten-free diet and immunosuppressive drugs (azathioprine, and currently remains asymptomatic. The patient's younger, 12-year-old sister was diagnosed with CD when she was 1.5 years old, and at 7 years she developed type-I diabetes mellitus, which was difficult to control. A family study was made, and both parents were found to be affected with silent CD. All were DQ2 (+. In relation to the case and family study, we provide a series of comments related to CD and its complications.Presentamos el caso de un varón de 17 años, que a la edad de 7 años fue diagnosticado de enfermedad celiaca (EC junto con una colitis ulcerosa (CU y una colangitis esclerosante primaria (CEP asociadas. Fue tratado con DSG e inmuno-supresores tipo azatioprina y se encuentra asintomático en la actualidad. Su hermana menor de 12 años, fue diagnosticada de EC cuando tenía 1,5 años y a los 7 años desarrolló una DM tipo 1 de difícil control. Se realizó un estudio familiar y ambos padres están afectos de una EC silente. Todos ellos son DQ2 (+. A propósito del caso y estudio familiar, se hacen una serie de consideraciones sobre la enfermedad celiaca y el desarrollo de complicaciones.

  12. Avaliação isocinética de quadríceps e ísquios-tibiais nos atletas de jiu-jitsu - doi:10.5020/18061230.2005.p85

    Directory of Open Access Journals (Sweden)

    Marcelle Morgana Vieira de Assis

    2012-01-01

    Full Text Available O Jiu-jitsu é uma arte marcial de defesa pessoal fundamentada no princípio de derrotar o adversário entregando-se a ele e subjugando-o com sua própria força. Atletas de esportes de contato como futebol, basquete e principalmente as lutas como o Jiu-Jitsu têm em comum as freqüentes lesões no joelho. O propósito desse estudo foi avaliar a resposta isocinética de quadríceps e ísquios-tibiais durante a flexão e extensão de ambos os joelhos nos praticantes de Jiu-jitsu, por serem estas articulações bastante solicitadas nesta prática esportiva. O presente estudo transversal foi realizado nos meses de setembro a novembro de 2002 em uma academia situada na cidade de Fortaleza. Participaram como sujeitos da pesquisa 15 praticantes de Jiu-Jitsu, todos do sexo masculino, na faixa etária de 15 a 30 anos e com tempo de prática de 6 meses a 10 anos, sendo realizada uma avaliação de extensores e flexores do joelho através do Dinamômetro Isocinético Cybex Ortothron II. Os dados obtidos revelaram a presença de desequilíbrios musculares nestes praticantes, evidenciando a importância de um trabalho de condicionamento físico para a prevenção de lesões decorrentes de desarmonia muscular.

  13. Monetary Policy and Excessive Bank Risk Taking

    NARCIS (Netherlands)

    Agur, I.; Demertzis, M.

    2010-01-01

    If monetary policy is to aim at financial stability, how would it change? To analyze this question, this paper develops a general-form model with endogenous bank risk profiles. Policy rates affect both bank incentives to search for yield and the cost of wholesale funding. Financial stability

  14. Enhancing Adult Literacy. A Policy Guide.

    Science.gov (United States)

    Brizius, Jack; Foster, Susan

    This policy guide is designed to assist governors and state leaders in analyzing the issue of adult literacy and in proposing specific policy strategies for dealing with this national problem. The book offers practical guidance in two areas critical to effective action: it clarifies definitions of "literacy" and "illiteracy" and provides a…

  15. Portable Programmable Multifunction Body Fluids Analyzer Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Advanced Liquid Logic proposes to develop a very capable analyzer based on its digital microfluidic technology. Such an analyzer would be:  Capable of both...

  16. El colgajo muscular de hemitríceps sural para la cobertura de grandes defectos en la pierna: Experiencia de 9 años The sural hemitriceps muscular flap for reconstruction of large tissue defects of the leg: A 9 year experience

    Directory of Open Access Journals (Sweden)

    R. Graciano Balcón

    2009-09-01

    Full Text Available En el Instituto Nacional de Ortopedia y Traumatología de Montevideo, Uruguay, utilizamos el colgajo muscular de hemitríceps sural para reconstruir defectos de cobertura en traumatismos graves de pierna que asientan en el tercio medio y en la unión del tercio medio con el distal. El colgajo de hemitríceps sural permite cubrir exposiciones óseas más extensas que el colgajo de hemisóleo en forma aislada, con un menor tiempo quirúrgico y sin afectar a la potencia en la flexión plantar. Presentamos una serie de 13 casos clínicos de fracturas expuestas con importantes defectos de cobertura cutánea de la pierna, tratados con colgajos de hemitríceps durante el período marzo de 1999 a julio de 2008. El seguimiento promedio fue de 15 meses.The sural hemitriceps muscular flap is used in the National Institute of Orthopedics and Traumatology in Montevideo to reconstruct soft-tissue defects after severe lower extremity trauma on the middle third and the union of the middle and inferior third of the leg. The hemitriceps sural flap can successfully cover more extensive osseous exposure than the hemisoleus flap alone, with less surgical time and without affecting plantar flexion strength. A series of 13 cases is presented of leg open fractures with important cutaneous soft-tissue defect treated with hemitriceps flaps, operated on the period from march 1999 to july 2008. Average follow-up time was 15 months.

  17. Food policy an ethics

    DEFF Research Database (Denmark)

    Coff, Christian Eyde; Kemp, Peter

    2014-01-01

    makes of food policy a highly complex and diverse area. The entry opens with at description of the concept of policy and food policy and how it relates to ethical principles and values. The fourth section discusses some influental definitions of food policy. The final section contains a description......This entry gives an overview of food policy and major ethical principles that in the last decades have been proposed and advocated for in debates on food policy. Food policies touch upon a vast area of interrelated policies (like health, transport, environment, poverty, animal welfare etc.) which...... of ethical principles and ideas of relevance to food policy....

  18. Food policy an ethics

    DEFF Research Database (Denmark)

    Coff, Christian Eyde; Kemp, Peter

    2014-01-01

    This entry gives an overview of food policy and major ethical principles that in the last decades have been proposed and advocated for in debates on food policy. Food policies touch upon a vast area of interrelated policies (like health, transport, environment, poverty, animal welfare etc.) which...... makes of food policy a highly complex and diverse area. The entry opens with at description of the concept of policy and food policy and how it relates to ethical principles and values. The fourth section discusses some influental definitions of food policy. The final section contains a description...... of ethical principles and ideas of relevance to food policy....

  19. Research for health policy

    National Research Council Canada - National Science Library

    Bell, Erica

    2010-01-01

    ... Explicit, implicit, and pragmatic dimensions of policy-maker's needs and context 31 Constraints on policy-makers 32 Deciphering trade-offs 33 The policy-problem: deciphering uncertainty and the problem of innovation 34 A tool for deciphering policy problems 35 The different components of the policy problem 37 Recommended reading 38 Case studies in...

  20. Reproductive Health Policy in Tunisia

    Science.gov (United States)

    Goicolea, Isabel; Hernandez, Alison

    2016-01-01

    Abstract Although Tunisia is regarded as a pioneer in the Middle East and North Africa in terms of women’s status and rights, including sexual and reproductive health and rights, evidence points to a number of persisting challenges. This article uses the Health Rights of Women Assessment Instrument (HeRWAI) to analyze Tunisia’s reproductive health policy between 1994 and 2014. It explores the extent to which reproductive rights have been incorporated into the country’s reproductive health policy, the gaps in the implementation of this policy, and the influence of this policy on gender empowerment. Our results reveal that progress has been slow in terms of incorporating reproductive rights into the national reproductive health policy. Furthermore, the implementation of this policy has fallen short, as demonstrated by regional inequities in the accessibility and availability of reproductive health services, the low quality of maternal health care services, and discriminatory practices. Finally, the government’s lack of meaningful engagement in advancing gender empowerment stands in the way as the main challenge to gender equality in Tunisia. PMID:28559685

  1. Creditor Governance and Corporate Policies

    DEFF Research Database (Denmark)

    Arnold, Marc; Westermann, Ramona

    This paper analyzes the impact of debt covenant renegotiations on corporate policies. We develop a structural model of a levered firm that can renegotiate debt both at investment and in corporate distress. Covenant renegotiation at investment disciplines equity holders in their financing...... and investment decisions and, hence, mitigates the agency cost of debt. Our model explains the empirical intensity and patterns of the occurrence of debt renegotiation. We also quantify the role of debt covenant renegotiations as a governance channel on corporate financial policies and on the value of corporate...

  2. Analyzing Bullwhip Effect in Supply Networks under Exogenous Uncertainty

    Directory of Open Access Journals (Sweden)

    Mitra Darvish

    2014-05-01

    Full Text Available This paper explains a model for analyzing and measuring the propagation of order amplifications (i.e. bullwhip effect for a single-product supply network topology considering exogenous uncertainty and linear and time-invariant inventory management policies for network entities. The stream of orders placed by each entity of the network is characterized assuming customer demand is ergodic. In fact, we propose an exact formula in order to measure the bullwhip effect in the addressed supply network topology considering the system in Markovian chain framework and presenting a matrix of network member relationships and relevant order sequences. The formula turns out using a mathematical method called frequency domain analysis. The major contribution of this paper is analyzing the bullwhip effect considering exogenous uncertainty in supply networks and using the Fourier transform in order to simplify the relevant calculations. We present a number of numerical examples to assess the analytical results accuracy in quantifying the bullwhip effect.

  3. Health Care Organizations and Policy Leadership: Perspectives on Nonsmoker-Only Hiring Policies.

    Science.gov (United States)

    McDaniel, Patricia A; Malone, Ruth E

    2018-02-01

    To explore employers' decisions to base hiring policies on tobacco or nicotine use and community perspectives on such policies, and analyze the implications for organizational identity, community engagement, and health promotion. From 2013 to 2016, 11 executives from six health care organizations and one non-health-care organization with nonsmoker-only hiring policies were interviewed about why and how their policies were created and implemented, concerns about the policies, and perceptions of employee and public reactions. Focus groups were conducted with community members (n = 51) who lived in or near cities where participating employers were based, exploring participants' opinions about why an employer would stop hiring smokers and their support (or not) for such a policy. Most employers excluded from employment those using all forms of nicotine. Several explained their adoption of the policy as a natural extension of a smoke-free campus and as consistent with their identity as health care organizations. They regarded the policy as promoting health. No employer mentioned engaging in a community dialogue before adopting the policy or reported efforts to track the policy's impact on rejected applicants. Community members understood the cost-saving appeal of such policies, but most opposed them. They made few exceptions for health care organizations. Policy decisions undertaken by health care organizations have influence beyond their immediate setting and may establish precedents that others follow. Nonsmoker-only hiring policies may fit with a health care organization's institutional identity but may not be congruent with community values or promote public health.

  4. Policy Archaeology: A New Policy Studies Methodology.

    Science.gov (United States)

    Scheurich, James Joseph

    1994-01-01

    Discusses policy archaeology, a radically different approach to policy studies in education drawn from the poststructuralist work of Foucault. Policy archaeology examines the social construction of problems before they become visible, focusing on five social regularities (race, gender, class, governmentality, and professionalization) comprising…

  5. Using expert systems to analyze ATE data

    Science.gov (United States)

    Harrington, Jim

    1994-01-01

    The proliferation of automatic test equipment (ATE) is resulting in the generation of large amounts of component data. Some of this component data is not accurate due to the presence of noise. Analyzing this data requires the use of new techniques. This paper describes the process of developing an expert system to analyze ATE data and provides an example rule in the CLIPS language for analyzing trip thresholds for high gain/high speed comparators.

  6. Electrical spectrum & network analyzers a practical approach

    CERN Document Server

    Helfrick, Albert D

    1991-01-01

    This book presents fundamentals and the latest techniques of electrical spectrum analysis. It focuses on instruments and techniques used on spectrum and network analysis, rather than theory. The book covers the use of spectrum analyzers, tracking generators, and network analyzers. Filled with practical examples, the book presents techniques that are widely used in signal processing and communications applications, yet are difficult to find in most literature.Key Features* Presents numerous practical examples, including actual spectrum analyzer circuits* Instruction on how to us

  7. ADAM: Analyzer for Dialectal Arabic Morphology

    Directory of Open Access Journals (Sweden)

    Wael Salloum

    2014-12-01

    Full Text Available While Modern Standard Arabic (MSA has many resources, Arabic Dialects, the primarily spoken local varieties of Arabic, are quite impoverished in this regard. In this article, we present ADAM (Analyzer for Dialectal Arabic Morphology. ADAM is a poor man’s solution to quickly develop morphological analyzers for dialectal Arabic. ADAM has roughly half the out-of-vocabulary rate of a state-of-the-art MSA analyzer and is comparable in its recall performance to an Egyptian dialectal morphological analyzer that took years and expensive resources to build.

  8. Environmental policy performance revisited

    DEFF Research Database (Denmark)

    Daugbjerg, Carsten; Sønderskov, Kim Mannemar

    2012-01-01

    Studies of environmental policy performance tend to concentrate on the impact of particular policy institutions or of single policy instruments. However, environmental policies most often consist of a package of policy instruments. Further, these studies pay no or very little attention to policy......-country variation in organic food consumption is explained by differences in the packages of policy instruments applied, controlling for numerous systemic and individual-level alternative explanations. The analysis suggests that for environmental and political reasons, governments should apply more demand......-side instruments when introducing environmental policies....

  9. Policy Feedback System (PFS)

    Data.gov (United States)

    Social Security Administration — The Policy Feedback System (PFS) is a web application developed by the Office of Disability Policy Management Information (ODPMI) team that gathers empirical data...

  10. A influência da mobilização articular nas tendinopatias dos músculos bíceps braquial e supra-espinal The influence of joint mobilization on tendinopathy of the biceps brachii and supraspinatus muscles

    Directory of Open Access Journals (Sweden)

    RI Barbosa

    2008-08-01

    Full Text Available As causas mais comuns de dor no ombro estão relacionadas às degenerações dos tendões da musculatura do manguito rotador. OBJETIVO: Verificar a influência da mobilização articular por meio dos movimentos acessórios do ombro na recuperação inicial de 14 pacientes com tendinopatia crônica dos mm. supra-espinal e/ou bíceps braquial. MÉTODOS: Foram comparados dois protocolos de tratamento, compostos da aplicação de ultra-som terapêutico na área do tendão afetado e de treinamento excêntrico na musculatura envolvida, acompanhados ou não de manobras de mobilização articular. Como métodos de avaliação foram utilizados os questionários de Constant e Disabilities of the Arm, Shoulder and Hand (DASH, no início e ao final do tratamento. RESULTADOS: Os resultados encontrados demonstraram que ambos os protocolos de tratamento foram eficazes na reabilitação dos pacientes, pois se obtiveram melhores resultados funcionais na aplicação dos questionários quando comparados o final com o início do tratamento para os pacientes (pThe most common causes of shoulder pain are related to degeneration of the tendons of the rotator cuff muscles. OBJECTIVE: To investigate the influence of joint mobilization by means of accessory movements of the shoulder during the early rehabilitation of 14 patients with chronic tendinopathy of the supraspinatus and/or biceps brachii muscles. METHODS: Two treatment protocols were compared: application of therapeutic ultrasound over the affected tendon area and eccentric training of the musculature involved, with or without joint mobilization maneuvers. The Constant and DASH (Disabilities of the Arm, Shoulder and Hand questionnaires were used as the assessment method, before and after the treatment. RESULTS: The results showed that both treatment protocols were effective for patient rehabilitation, since better functional results were obtained at the end of the treatment, in comparison with the beginning (p<0

  11. impacts of alternative farm policies on rural communities

    Science.gov (United States)

    J. Michael Bowker; James W. Richardson

    1989-01-01

    The purpose of this study was to describe an LP/IO model for evaluating the economic impacts of alternative farm policies on rural communities and demonstrate its capabilities by analyzing the impacts of three farm policies on a rural community in Texas. Results indicate that in the noncrop sector, two groups of industries are most affected by farm policy. The first...

  12. New Agenda: South African Journal of Social and Economic Policy ...

    African Journals Online (AJOL)

    New Agenda: South African Journal of Social and Economic Policy: Editorial Policies. Journal Home > About the Journal ... This is a policy journal analyzing social and economic issues in South Africa. We publish infomed articles by experts and ... Publication Frequency. This journal publishes quarterly (4 issues per year).

  13. England Policy in Gifted Education: Current Problems and Promising Directions

    Science.gov (United States)

    Koshy, Valsa; Smith, Carole Portman; Casey, Ronald

    2018-01-01

    This article presents and analyzes policies in identification and provisions in England with respect to gifted education. England has developed a national policy to provide services to identified students. Surveys and interviews with teachers illustrate how implementation of both identification and provision policy elements were handled. Although…

  14. Analyzing metabolomics-based challenge test

    NARCIS (Netherlands)

    Vis, D.J.; Westerhuis, J.A.; Jacobs, D.M.; van Duynhoven, J.P.M.; Wopereis, S.; van Ommen, B.; Hendriks, M.M.W.B.; Smilde, A.K.

    2015-01-01

    Challenge tests are used to assess the resilience of human beings to perturbations by analyzing responses to detect functional abnormalities. Well known examples are allergy tests and glucose tolerance tests. Increasingly, metabolomics analysis of blood or serum samples is used to analyze the

  15. Policy, Profession and Public Management

    DEFF Research Database (Denmark)

    Kann-Christensen, Nanna; Balling, Gitte

    with focus on an expressive logic, on the other hand, is defined by tolerance and inclusiveness both regarding forms of culture, types of aesthetic experiences and regarding participants. P for Profession: Professional logics The librarian profession has been analyzed and described several places. Some...... interconnected concerns that relates to literature promotion. Besides cultural policy we regard the logics of New Public Management (NPM) and professional logics in the field of public libraries. Cultural policy along with the identification of underlying logics present among politicians, government officials......). Theoretical perspectives In order to investigate how Policy, Public management and Professional logics interplay in the field of public libraries, this paper uses an institutional perspective. Institutional theory is concerned with the field level. The concept of institutional logics is well suited...

  16. Peak torque and knee kinematics during gait after eccentric isokinetic training of quadriceps in healthy subjects O pico de torque e a cinemática do joelho durante a marcha após treino isocinético excêntrico do quadríceps em sujeitos saudáveis

    Directory of Open Access Journals (Sweden)

    PR Poletto

    2008-08-01

    Full Text Available OBJECTIVE: To evaluate the effects of eccentric isokinetic training on knee range of motion (ROM of healthy subjects. METHODS: The knee extensor and flexor isokinetic peak torques and ROM of flexion/extension and varus/valgus knee movements during gait of 18 healthy men (21.7±2.2 years; 1.73±0.10m; 68.7±9.4kg; body mass index: 22.6±2kg/m² were analyzed, before and after six weeks of bilateral eccentric isokinetic training of the knee extensors at 30º/s. RESULTS: The knee extensor torque increased in both limbs (right, from 229±54 to 304±53Nm; pOBJETIVO: Avaliar os efeitos do treino isocinético excêntrico sobre a amplitude de movimento (ADM do joelho em sujeitos saudáveis. MÉTODOS: Foram analisados os picos de torque isocinético dos extensores e flexores do joelho e a ADM de flexo/extensão e valgo/varo, durante a marcha, de 18 homens saudáveis (21,7±2,2 anos; 1,73±0,10m; 68,7±9,4kg; índice de massa corpórea: 22,6±2kg/m² antes e após seis semanas de treino isocinético excêntrico bilateral dos extensores do joelho a 30º/s. RESULTADOS: O torque extensor do joelho aumentou em ambos os membros, direito (de 229±54 para 304±53Nm; p<0,01 e esquerdo (de 228±59 para 311±63Nm; p<0,01 sem diferença de ganho de torque entre eles. O pico de torque flexor aumentou (de 114±30 para 123±22Nm; p<0,05, mas a razão isquiotibiais/quadríceps (I/Q diminuiu (de 0,5±0,08 para 0,39±0,07; p<0,01 após o treino. Não houve diferença para os movimentos de flexo/extensão e valgo/varo após o treino, exceto uma pequena mudança (4° no valgo para o joelho esquerdo. CONCLUSÕES: O treino isocinético excêntrico dos extensores do joelho aumentou o torque extensor e diminuiu a razão I/Q, entretanto o efeito sobre o padrão da marcha parece desprezível em sujeitos saudáveis. Um treino associado dos flexores, complementar ao treino dos extensores parece ser necessário para o equilíbrio entre agonistas e antagonistas do joelho.

  17. Turkey's Educational Policies in Central Asia and Caucasia: Perceptions of Policy Makers and Experts

    Science.gov (United States)

    Akcali, Pinar; Engin-Demir, Cennet

    2012-01-01

    The purpose of this study is to analyze the educational policies of Turkey in Central Asia and Caucasia in the post-Soviet era in terms of their successes and failures as perceived by some of the relevant professional policy makers in this field as well as experts from various think-tank institutions in Turkey who are interested in the region.…

  18. Checklist "Open Access Policies": Analysis of the Open Access Policies of Public Universities in Austria

    Directory of Open Access Journals (Sweden)

    Bruno Bauer

    2016-12-01

    Full Text Available This checklist provides an overview of the Open Access policies implemented at Austrian universities and extramural research institutions. Furthermore, the polices adopted at nine public universities are analyzed and the respective text modules are categorized thematically. The second part of the checklist presents measures for the promotion of Open Access following the implementation of an Open Access policy.

  19. Institutional and policy responses to uncertainty in environmental policy: A comparison of dutch and US styles

    NARCIS (Netherlands)

    Arentsen, Maarten J.; Bressers, Johannes T.A.; O'Toole, Laurence J.

    2000-01-01

    Uncertainties regarding problem definition and policy response are an endemic pan of environmental decisionmaking. Some standard responses to uncertainty in decisionmaking are analyzed and then used to suggest the importance of learning-oriented policy processes in open, flexible, and adaptive

  20. Inherit the policy: A sociocultural approach to understanding evolutionary biology policy in South Carolina

    Science.gov (United States)

    Moore, Gregory D.

    South Carolina biology Indicator 5.6 calls for students to "Summarize ways that scientists use data from a variety of sources to investigate and critically analyze aspects of evolutionary theory" (South Carolina Department of Education, 2006). Levinson and Sutton (2001) offered a sociocultural approach to policy that considers cultural and historical influences at all levels of the policy process. Lipsky (1980/2010) and others have identified teachers as de facto policy makers, exercising broad discretion in the execution of their work. This study looks to Ajzen's Theory of Planned Behavior as an initial framework to inform how evolutionary biology policy in South Carolina is conceptualized and understood at different levels of the policy process. The results of this study indicate that actors in the state's evolutionary biology policy process draw upon a myriad of Discourses (Gee, 1999/2005). These Discourses shape cultural dynamics and the agency of the policy actors as they navigate conflicting messages between testing mandates and evolutionary biology policy. There indeed exist gaps between how evolutionary biology policy in South Carolina is conceptualized and understood at the different levels of the policy process. Evidence from this study suggests that appropriation-level policy actors must be brought into the Discourse related to the critical analysis of evolutionary biology and academic freedom legislation must be enacted if South Carolina biology Indicator 5.6 is to realize practical significance in educational policy.

  1. Evaluating a traditional medicine policy in South Africa: phase 1 development of a policy assessment tool.

    Science.gov (United States)

    Gavriilidis, Georgios; Östergren, Per-Olof

    2012-01-01

    Policies that empower individuals and communities may be appropriate for public health, and more broadly. Simple, transparent and acceptable tools are therefore required to evaluate policies from an empowerment perspective. In 2008, the South African Department of Health (DOHSA) drafted a policy to endorse the integration of African Traditional Medicine (ATM) into the public health sector, following the World Health Organization's (WHO) long-standing directives. The purpose of this study is to critically analyze this policy using a novel evaluation tool. A 12-point 'Policy Empowerment Index' (PEI) is introduced, and used to classify and score the policy according to five theoretical policy types. The evaluation was based on a stepwise review and associated publications: policy drafts, policy statements and news announcements. According to the assessment tool, the ATM policy was marginally 'supportive' of constituent empowerment, although several 'directive' features were also observed. The importance of ATM to SA's communities and the promotion of education, employment, entrepreneurship and peripheral resource mobilization were the main empowering elements. Centralised conception, planning and implementation, the absence of provisions for local adaptations and the authoritative legislation context were sub-optimal features. South Africa's ATM legislation may need to further involve communities in policy design and implementation to capitalise upon the broader benefits of community empowerment. However, the iterative nature of method and evaluation is important. Indeed, they are proposed as points to initiate participatory development, and improve policy evaluation. Such instruments can empower constituents in the political process.

  2. Dismantling the Afghan Opiate Economy: A Cultural and Historical Policy Assessment, with Policy Recommendations

    National Research Council Canada - National Science Library

    Byrom, Christopher L

    2005-01-01

    .... Specific lessons are taken from a chapter dedicated to Afghan culture, history, and rural power structures, and applied in chapters analyzing the opiate economy and current counter-narcotics policies...

  3. Time-delay analyzer with continuous discretization

    International Nuclear Information System (INIS)

    Bayatyan, G.L.; Darbinyan, K.T.; Mkrtchyan, K.K.; Stepanyan, S.S.

    1988-01-01

    A time-delay analyzer is described which when triggered by a start pulse of adjustable duration performs continuous discretization of the analyzed signal within nearly 22 ns time intervals, the recording in a memory unit with following slow read-out of the information to the computer and its processing. The time-delay analyzer consists of four CAMAC-VECTOR systems of unit width. With its help one can separate comparatively short, small-amplitude rare signals against the background of quasistationary noise processes. 4 refs.; 3 figs

  4. Systems Analyze Water Quality in Real Time

    Science.gov (United States)

    2010-01-01

    A water analyzer developed under Small Business Innovation Research (SBIR) contracts with Kennedy Space Center now monitors treatment processes at water and wastewater facilities around the world. Originally designed to provide real-time detection of nutrient levels in hydroponic solutions for growing plants in space, the ChemScan analyzer, produced by ASA Analytics Inc., of Waukesha, Wisconsin, utilizes spectrometry and chemometric algorithms to automatically analyze multiple parameters in the water treatment process with little need for maintenance, calibration, or operator intervention. The company has experienced a compound annual growth rate of 40 percent over its 15-year history as a direct result of the technology's success.

  5. Working for Policy

    NARCIS (Netherlands)

    Colebatch, H.K.; Hoppe, Robertus; Noordegraaf, Mirko

    2010-01-01

    Though democratic government calls for well-designed and implemented policy, there is surprisingly little expert guidance available for policy makers and politicians. Working for Policy fills that gap, addressing the nature of policy work and offering necessary guidance. The contributors bring

  6. Education Policy Outlook: Austria

    Science.gov (United States)

    Figueroa, Diana Toledo; Golden, Gillian; Giovinazzo, Manon; Peterka, Judith; Ullmann, Marie

    2017-01-01

    This policy profile on education in Austria is part of the "Education Policy Outlook" series, which presents comparative analysis of education policies and reforms across OECD countries. Building on the OECD's substantial comparative and sectoral knowledge base, the series offers a comparative outlook on education policy by providing…

  7. Isokinetic torque peak and hamstrings/quadriceps ratios in endurance athletes with anterior cruciate ligament laxity Pico de torque isocinético e relação ísquios-tibiais/quadríceps em atletas de endurance com frouxidão do ligamento cruzado anterior

    Directory of Open Access Journals (Sweden)

    Eliane Magaieski Portes

    2007-01-01

    Full Text Available PURPOSE: To evaluate torque and the hamstring/quadriceps ratio of the knee of athletes with and without anterior cruciate ligament laxity. METHODS: Twenty-eight male athletes, 19 without anterior cruciate ligament laxity and 9 with anterior cruciate ligament laxity, were evaluated with an isokinetic machine model Cybex 770. The peak torque of quadriceps and hamstrings was compared, and the hamstring/quadriceps ratio on the constant angular speed of 60º per second were also compared. RESULTS: In athletes with anterior cruciate ligament laxity, the peak torque values (right and left knees of flexors (120 ± 15 and 116 ± 15 Nm and of extensors (218 ± 36 Nm and 207 ± 26 Nm were not different than those of athletes without laxity (109 ± 21 Nm and 111 ± 22 Nm; 191 ± 5 Nm and 188 ± 35 Nm. The hamstring/quadriceps ratio of athletes with laxity (right: 57 ± 6% and left: 56 ± 8% did not differ from those without anterior cruciate ligament laxity (right: 58 ± 9% and left: 58 ± 7%. CONCLUSIONS: The anterior cruciate ligament laxity of long distances running athletes did not significantly alter the peak torque of flexors and of extensors or the hamstring/quadriceps ratio.OBJETIVO: Avaliar o torque e a relação de forças entre ísquios-tibiais/quadríceps dos joelhos de atletas corredores de longas distâncias com e sem frouxidão do ligamento cruzado anterior. METODOLOGIA: Vinte e oito atletas do gênero masculino, 19 sem frouxidão do ligamento cruzado anterior e 9 com frouxidão do ligamento cruzado anterior foram avaliados com aparelho isocinético modelo Cybex 770. Comparou-se o pico de torque dos quadríceps e dos ísquios-tibiais e a relação ísquios-tibiais/quadríceps na velocidade angular constante de 60º por segundo. Os dados obtidos foram comparados por meio dos testes t de Student e para dados pareados (membros direito e esquerdo e o nível de significância estabelecido foi p < 0,05. RESULTADOS: Nos atletas com frouxidão do

  8. My Summer with Science Policy

    Science.gov (United States)

    Murray, Marissa

    This past summer I interned at the American Institute of Physics and helped research and write articles for the FYI Science Policy Bulletin. FYI is an objective digest of science policy developments in Washington, D.C. that impact the greater physical sciences community. Over the course of the summer, I independently attended, analyzed, and reported on a variety of science, technology, and funding related events including congressional hearings, government agency advisory committee meetings, and scientific society events. I wrote and co-wrote three articles on basic energy research legislation, the National Institute of Standards and Technology improvement act, and the National Science Foundation's big ideas for future investment. I had the opportunity to examine some challenging questions such as what is the role of government in funding applied research? How should science priorities be set? What is the right balance of funding across different agencies and programs? I learned about how science policy is a two-way street: science is used to inform policy decisions and policy is made to fund and regulate the conduct of science. I will conclude with how my summer working with FYI showed me the importance of science advocacy, being informed, and voting. Society of Physics Students.

  9. Unemployment effects of climate policy

    International Nuclear Information System (INIS)

    Babiker, Mustafa H.; Eckaus, Richard S.

    2007-01-01

    This paper models the unemployment effects of restrictions on greenhouse gas emissions, embodying two of the most significant types of short-term economic imperfections that generate unemployment: sectoral rigidities in labor mobility and sectoral rigidities in wage adjustments. A labor policy is also analyzed that would reduce the direct negative economic effects of the emissions restrictions. The politics of limiting greenhouse gas emissions are often dominated by relatively short-term considerations. Yet the current economic modeling of emissions limitations does not embody economic features that are likely to be particularly important in the short term, in particular, the politically sensitive unemployment rate. Moreover, only a few of these studies also consider policies that would offset the negative direct economic effects of emissions restrictions. For plausible estimates of the parameters, the model shows that, with the labor market imperfections, if there were no offsetting policies, the reductions in GNP in the U.S. in the first 10 years after emissions restrictions were imposed would be as much as 4%. However, if there were two policies, instead of just one: a counteracting labor market policy, as well as the emissions restrictions, the negative direct economic effects could be completely eliminated

  10. Environmental policy in Japan

    Energy Technology Data Exchange (ETDEWEB)

    Tsuru, Shigeto; Weidner, H. (eds.)

    1989-01-01

    This book deals in English with the most important features of Japanese environmental policy in a number of individual articles by different authors. The various sections report on: 1. History and organization of environmental policy; 2. The role of non-governmental actors in environmental policy (large industries); 3. Special features of environmental policies and problems; 4. Classical pollution control areas: Regulations and effects; 5. Environmental problems in a broader perspective (nature conservation); 6. Policy areas with influence on environmental quality; 7. Environmental monitoring and reporting; 8. Japanese environmental policy in an international perspective (preventive policies, developing countries). (HSCH).

  11. Policy for Sustainable Entrepreneurship

    DEFF Research Database (Denmark)

    Watson, Rosina; Nielsen, Kristian Roed; Wilson, Hugh N.

    Sustainable entrepreneurship—entrepreneurship with social and ecological gains as well as economic ones—can significantly address societal and environmental challenges, however, it is not clear how policy can support it. The authors develop a policy framework for sustainable entrepreneurship, using...... impact/performance; and innovating government. Contributions to entrepreneurship policy literature include measuring impact/performance and open policy innovation for entrepreneurship policy. Contributions to sustainability policy literature include empowering individuals as entrepreneurs and not just...... consumers. A sustainable entrepreneurship framework is developed. A method for crowdsourcing policy innovations is outlined....

  12. A Study on the Nuclear Technology Policy

    International Nuclear Information System (INIS)

    Lim, C. Y.; Lee, K. S.; Jeong, I.; Lee, J. H.

    2009-04-01

    The objective of the study was to make policy-proposes for enhancing the effectiveness and efficiency of national nuclear technology development programs. To do this, recent changes of international nuclear energy policy and trends of nuclear technology R and D was surveyed and analyzed. In the viewpoint of analysis of the changes in the global policy surrounding nuclear technology development and development of national nuclear R and D strategy, this study (1) analyzed the trends of nuclear technology policies and (2) discussed the mid and long term strategy of nuclear energy R and D. To put it in more detail, each subject was further explored as follows; (1) analyzed the trends of nuclear technology policies - Trend and prospects of the international and domestic nuclear policies - Investigation of development of small and medium sized policies - International collaboration for advanced nuclear technologies (2) discussed the mid and long term strategy of nuclear energy R and D - The long term development plan for future nuclear energy system - The facilitation of technology commercialization

  13. Low Gravity Drug Stability Analyzer Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The goal of this proposed program through Phase III is to build a space-worthy Drug Stability Analyzer that can determine the extent of drug degradation. It will be...

  14. On-Demand Urine Analyzer, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — The overall goal of this program (through Phase III) is to develop an analyzer that can be integrated into International Space Station (ISS) toilets to measure key...

  15. Low Gravity Drug Stability Analyzer Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The overall goal of this proposed program (through Phase III) is to build a space-worthy Drug Stability Analyzer that can determine the extent of drug degradation....

  16. Analyzing the economic impacts of transportation projects.

    Science.gov (United States)

    2013-09-01

    The main goal of the study is to explore methods, approaches and : analytical software tools for analyzing economic activity that results from largescale : transportation investments in Connecticut. The primary conclusion is that the : transportation...

  17. Low Gravity Drug Stability Analyzer, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — The overall goal of this proposed program (through Phase III) is to build a space-worthy Drug Stability Analyzer that can determine the extent of drug degradation....

  18. Guide to analyzing investment options using TWIGS.

    Science.gov (United States)

    Charles R Blinn; Dietmar W. Rose; Monique L. Belli

    1988-01-01

    Describes methods for analyzing economic return of simulated stand management alternatives in TWIGS. Defines and discusses net present value, equivalent annual income, soil expectation value, and real vs. nominal analyses. Discusses risk and sensitivity analysis when comparing alternatives.

  19. Ultrasensitive Atmospheric Analyzer for Miniature UAVs Project

    Data.gov (United States)

    National Aeronautics and Space Administration — In this SBIR Phase I effort, Los Gatos Research (LGR) proposes to develop a highly-accurate, lightweight, low-power gas analyzer for quantification of water vapor...

  20. Analyzing Protein Dynamics Using Dimensionality Reduction

    OpenAIRE

    Eryol, Atahan

    2015-01-01

    This thesis investigates dimensionality reduction for analyzing the dynamics ofprotein simulations, particularly disordered proteins which do not fold into a xedshape but are thought to perform their functions through their movements. Ratherthan analyze the movement of the proteins in 3D space, we use dimensionalityreduction to project the molecular structure of the proteins into a target space inwhich each structure is represented as a point. All that is needed to do this arethe pairwise dis...

  1. Digital dynamic amplitude-frequency spectra analyzer

    International Nuclear Information System (INIS)

    Kalinnikov, V.A.; )

    2006-01-01

    The spectra analyzer is intended for the dynamic spectral analysis of signals physical installations and noise filtering. The recurrence Fourier transformation algorithm is used in the digital dynamic analyzer. It is realized on the basis of the fast logic FPGA matrix and the special signal ADSP microprocessor. The discretization frequency is 2 kHz-10 MHz. The number of calculated spectral coefficients is not less 512. The functional fast-action is 20 ns [ru

  2. Shopping as ‘Best Practice’ - Analyzing Walmart’s Debated Sustainability Policies

    OpenAIRE

    Лючия Аббамонте; Флавия Кавальери

    2017-01-01

    Nowadays, companies who want to engage environment-friendly consumers increasingly rely on green-economy oriented campaigns. Such categories of (ethical) consumers are numerically increasing, and expressions evoking environmental friendliness are becoming particularly trendy. In this vein, words such as ‘sustainability’ have been variously recontextualized/reframed and have become an ‘ought to’ for media-savvy companies ‘with a vision’ - Walmart, the American multinational retail corporation,...

  3. Shopping as ‘Best Practice’ - Analyzing Walmart’s Debated Sustainability Policies

    Directory of Open Access Journals (Sweden)

    Лючия Аббамонте

    2017-12-01

    Full Text Available Nowadays, companies who want to engage environment-friendly consumers increasingly rely on green-economy oriented campaigns. Such categories of (ethical consumers are numerically increasing, and expressions evoking environmental friendliness are becoming particularly trendy. In this vein, words such as ‘sustainability’ have been variously recontextualized/reframed and have become an ‘ought to’ for media-savvy companies ‘with a vision’ - Walmart, the American multinational retail corporation, being a relevant case in point. It is no accident that, on the first Google page for ‘sustainability’, ‘Walmart’ proudly surfaces:http://corporate.walmart.com/global-responsibility/sustainability. The company has made an explicit commitment not just to expand the business but also to improve communities and enhance the sustainability of the products they sell, by encouraging more responsible production practices, while at the same time making product choices more affordable for customers, as reported on its website. However, as the world’s largest company, Walmart is an easy target for attack mainly by environmentalists. Sometimes, Walmart gives its critics grounds for some legitimate criticism in a variety of fields ranging from the supply chain emissions to renewable energy and preserving habitat. Such criticism resonates across the media, owing to their ‘lack of closure’ (Laclau and Mouffe 1985, finalized to offer an unbiased perspective. Against this ‘complexified’ (Macgilchrist 2007 background, our study aims to examine, from a broadly Multimodal and Positive Discourse Analysis perspective, the Walmart website ‘sustainability’ pages with their variety of communicative strategies, advertising ‘responsible’ Walmart positive attitudes to fundamental issues like Energy, Waste, Products and Responsible Sourcing.

  4. The Future of Drone Strikes: A Framework for Analyzing Policy Options

    Science.gov (United States)

    2014-09-01

    2011, http://www.gpo.gov/ fdsys/pkg/CHRG-112shrg68241/html/CHRG-112shrg 68241.htm. [11] Hakim Almasmari, “Yemen says US drone struck a wedding convoy...killing 14,” CNN, December 13, 2013, http://www. cnn.com/2013/12/12/world/meast/yemen-u-s-drone- wedding /. [12] Letter to Attorney General Holder...Jane Perlez, “ Chinese plan to kill drug lord with drone high- lights military advances,” The New York Times, February 20, 2013, http

  5. Cybersecurity via Intermediaries : Analyzing Security Measurements to Understand Intermediary Incentives and Inform Public Policy

    NARCIS (Netherlands)

    Asghari, H.

    2016-01-01

    Research in the field of information security economics has clarified how attacker and defender incentives affect cybersecurity. It has also highlighted the role of intermediaries in strengthening cybersecurity. Intermediaries are organizations and firms that provide the Internet’s infrastructure

  6. Analyzing Environmental Policies for Chlorinated Solvents with a Model of Markets and Regulations

    Science.gov (United States)

    1991-01-01

    contributes to stratospheric ozone depletion. TCA is now being regulated more stringently, and one of the major substitute solvents contains d- limonene , which...ingredient of most cleaning formulations, d- limonene , has generated positive carcinogenicity results in male rats. -2- 500 TCE + S400 TCA 3 00 200 C 100 - 0...Regulators banned CFC propellants from aerosol products in December 1978. - 17 - OSlA. The Occupational Safety and Health Administration (OSHA) regulates

  7. AN ECONOMIC PERSPECTIVE AND POLICY IMPLICATION FOR SOCIAL ENTERPRISE

    OpenAIRE

    Yoon-Doo Kim; Seok Yoon; Heon-Goo Kim

    2014-01-01

    This study looked at the current status of Korean social enterprises and their problems and suggested governmental policy implications for enhancing the competitiveness of social enterprises. As the study methods, the current status of social enterprises was analyzed and performance of social enterprise support was examined and then policy implications for promoting the social enterprises were analyzed. First, the direction of governmental policy regarding the promotion of social enterprise s...

  8. Policies for the inclusion of disabled people: limits and possibilities

    OpenAIRE

    França,Inacia Sátiro Xavier de; Pagliuca,Lorita Marlena Freitag; Baptista,Rosilene Santos

    2008-01-01

    This study aimed to investigate the impact of the National Policy for the Integration of Disabled People in Brazil and to analyze which aspects of this policy are evidenced in academic publications. Data were collected in indexed databases and academic bibliography. The sample composition criteria permitted the inclusion of texts on social inclusion and public inclusion policies. Data were analyzed according to Thematic Content Analysis. It is concluded that disabled people have conquered a p...

  9. Clean Energy Policy Analyses: Analysis of the Status and Impact of Clean Energy Policies at the Local Level

    Energy Technology Data Exchange (ETDEWEB)

    Busche, S.

    2010-12-01

    This report takes a broad look at the status of local clean energy policies in the United States to develop a better understanding of local clean energy policy development and the interaction between state and local policies. To date, the majority of clean energy policy research focuses on the state and federal levels. While there has been a substantial amount of research on local level climate change initiatives, this is one of the first analyses of clean energy policies separate from climate change initiatives. This report is one in a suite of reports analyzing clean energy and climate policy development at the local, state, and regional levels.

  10. Clean Energy Policy Analyses. Analysis of the Status and Impact of Clean Energy Policies at the Local Level

    Energy Technology Data Exchange (ETDEWEB)

    Busche, S. [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2010-12-01

    This report takes a broad look at the status of local clean energy policies in the United States to develop a better understanding of local clean energy policy development and the interaction between state and local policies. To date, the majority of clean energy policy research focuses on the state and federal levels. While there has been a substantial amount of research on local level climate change initiatives, this is one of the first analyses of clean energy policies separate from climate change initiatives. This report is one in a suite of reports analyzing clean energy and climate policy development at the local, state, and regional levels.

  11. The dynamics of energy policy in Lebanon when research, politics, and policy fail to intersect

    International Nuclear Information System (INIS)

    Khodr, Hiba; Uherova Hasbani, Katarina

    2013-01-01

    This paper is an exploratory study on energy policymaking in Lebanon aiming at investigating the contributing factors to the absence of evidence-informed policy by analyzing the relation between energy-related research and policy. It uses a qualitative approach in which two complementary types of data sources are employed. Data was mainly obtained from in-depth semi-structured interviews conducted with 40 key stakeholders. The data was further enhanced by an extensive review of related documents available in the public domain as well as research-related activities. Data were analyzed using iterative thematic content analysis which findings served to illustrate the theoretical perspectives in the relevant prevailing literature on linking policy and research. This paper suggests that the politicization of energy policy, the nature of the generated evidence and the lack of communication of evidence among policy actors as well as the weak and non-institutionalized links between researchers and policymakers have posed as an obstacle to an effective, efficient and evidence-based policy. There is a dearth of academic studies that have investigated this issue from a policy perspective. The analysis lays the foundation for much needed future studies on the country's energy policy by identifying the participants, mapping out the process and providing policy recommendations. - Highlights: • We study energy policymaking in Lebanon. • We analyze the relation between research and policy. • We identify contributing factors to the absence of evidence-informed policy. • The politicization of policy and nature of research have posed as obstacles. • Evidence of non-institutionalized links between researchers and policymakers

  12. Affective Policy Performance Evaluation Model: A Case of an International Trade Policy Implementation

    Directory of Open Access Journals (Sweden)

    Inwon Kang

    2018-01-01

    Full Text Available Firms often superficially adopt policies because of governmental rules and regulations, so as to avoid penalties or to gain benefits. However, the evaluation and characterization of those kinds of adoptions as policy performance distorts the true level of policy performance: social sustainability. This study proposes an affective policy performance evaluation model. The attitudes of employees toward adopting a policy are characterized into genuine and superficial compliance. Their behaviors are explained through voluntary and opportunistic adoptions. In order to validate the proposed model, a survey was conducted on an international trade policy target group (n = 216 for the Strategic Trade Control System (STCS, in order to understand their attitudes toward adopting the policy. The survey data was analyzed by a structural equation modeling method. The measures of the factors in the proposed model are adopted and modified from existing studies. The most effective resources of policy implementation on the firms’ genuine and superficial compliance and ultimately on the firms’ voluntary policy adoption are revealed through the analysis. Based on the results, this study presents a strategy for allocating and managing policy implementation resources to exclusively encourage firms’ trade policy adoptions.

  13. Corporate Language Policies

    DEFF Research Database (Denmark)

    Sanden, Guro Refsum

    This paper offers a review of literature dealing with language policies in general and corporate language policies in particular. Based on a discussion of various definitions of these concepts within two research traditions, i.e. sociolinguistics and international management, a three......-level definition of corporate language policies is presented, emphasising that a corporate language policy is a context-specific policy about language use. The three-level definition is based on the argument that in order to acquire a complete understanding of what corporate language policies involve, one needs...... to consider three progressive questions; 1) what is a policy? 2) what is a language policy?, and ultimately, 3) what is a corporate language policy?...

  14. Corporate Language Policies

    DEFF Research Database (Denmark)

    Sanden, Guro Refsum

    2015-01-01

    This paper offers a review of literature dealing with language policies in general and corporate language policies in particular. Based on a discussion of various definitions of these concepts within two research traditions, i.e. sociolinguistics and international management, a three......-level definition of corporate language policies is presented, emphasising that a corporate language policy is a context-specific policy about language use. The three-level definition is based on the argument that in order to acquire a complete understanding of what corporate language policies involve, one needs...... to consider three progressive questions; 1) what is a policy? 2) what is a language policy?, and ultimately, 3) what is a corporate language policy?...

  15. Marketization of higher education in Vietnam in the era of neoliberal globalization: policy and practice

    OpenAIRE

    Nguyen, Hien Thi

    2009-01-01

    Using a qualitative research approach, this study investigates how a neoliberal policy agenda and the global trend of marketization in higher education have influenced higher education policies in Vietnam. The major part of this study analyzes national policy documents and related literature to identify policy determinants and policy trends at the national level. The secondary part provides a critically reflective analysis of institutional responses to national policies. This study finds that...

  16. Analyzing Fiscal Balance Evolution for Developed and Emerging Countries

    Directory of Open Access Journals (Sweden)

    Dinca Gheorghita

    2016-11-01

    Full Text Available The purpose of our paper is to analyze the main factors which influence fiscal balance’s evolution and thereby identify solutions for configuring a sustainable fiscal policy. We have selected as independent variables some of the main macroeconomic measures, respectively public debt, unemployment rate, economy openness degree, population, consumer goods’ price index, current account balance, direct foreign investments and economic growth rate. Our research method uses two econometric models applied on a sample of 22 countries, respectively 14 developed and 8 emergent. The first model is a multiple regression and studies the connection between the fiscal balance and selected independent variables, whereas the second one uses first order differences and introduces economic freedom as a dummy variable to catch the dynamic influences of selected measures upon fiscal result. The time interval considered was 1999-2013. The results generated using the two models revealed that public debt, current account balance and economic growth significantly influence the fiscal balance. As a consequence, the governments need to plan and implement a fiscal policy which resonates with economy priorities and the phase of the economic cycle, as well as ensure a proper management of the public debt, stimulate sustainable economic growth and employment.

  17. Detecting and analyzing research communities in longitudinal scientific networks.

    Directory of Open Access Journals (Sweden)

    Valerio Leone Sciabolazza

    Full Text Available A growing body of evidence shows that collaborative teams and communities tend to produce the highest-impact scientific work. This paper proposes a new method to (1 Identify collaborative communities in longitudinal scientific networks, and (2 Evaluate the impact of specific research institutes, services or policies on the interdisciplinary collaboration between these communities. First, we apply community-detection algorithms to cross-sectional scientific collaboration networks and analyze different types of co-membership in the resulting subgroups over time. This analysis summarizes large amounts of longitudinal network data to extract sets of research communities whose members have consistently collaborated or shared collaborators over time. Second, we construct networks of cross-community interactions and estimate Exponential Random Graph Models to predict the formation of interdisciplinary collaborations between different communities. The method is applied to longitudinal data on publication and grant collaborations at the University of Florida. Results show that similar institutional affiliation, spatial proximity, transitivity effects, and use of the same research services predict higher degree of interdisciplinary collaboration between research communities. Our application also illustrates how the identification of research communities in longitudinal data and the analysis of cross-community network formation can be used to measure the growth of interdisciplinary team science at a research university, and to evaluate its association with research policies, services or institutes.

  18. Analyzing Log Files using Data-Mining

    Directory of Open Access Journals (Sweden)

    Marius Mihut

    2008-01-01

    Full Text Available Information systems (i.e. servers, applications and communication devices create a large amount of monitoring data that are saved as log files. For analyzing them, a data-mining approach is helpful. This article presents the steps which are necessary for creating an ‘analyzing instrument’, based on an open source software called Waikato Environment for Knowledge Analysis (Weka [1]. For exemplification, a system log file created by a Windows-based operating system, is used as input file.

  19. A Novel Architecture For Multichannel Analyzer

    International Nuclear Information System (INIS)

    Marcus, E.; Elhanani, I.; Nir, J.; Ellenbogen, M.; Kadmon, Y.; Tirosh, D.

    1999-01-01

    A novel digital approach to real-time, high-throughput, low-cost Multichannel Analyzer (MCA) for radiation spectroscopy is being presented. The MCA input is a shaped nuclear pulse sampled at a high rate, using an Analog-to-Digital Converter (ADC) chip. The digital samples are analyzed by a state-of-the-art Field Programmable Gate Away (FPGA). A customized algorithm is utilized to estimate the peak of the pulse, to reject pile-up and to eliminate processing dead time. The valid pulses estimated peaks are transferred to a micro controller system that creates the histogram and controls the Human Machine Interface (HMI)

  20. Advances on CT analyzing urolithiasis constituents

    International Nuclear Information System (INIS)

    Feng Qiang; Ma Zhijun

    2009-01-01

    Urolithiasis is common and frequently-occurring diseases of urology. The treatment of lithiasis is not only relevant with the size, location, brittle and infection of calculi, but also affected by urolithiasis constituents. Knowing the urolithiasis constituents in advance is no doubt to guide treatment. But so far an reliable inspection method was not found to analyze accurately urolithiasis constituents in vivo. CT judge precisely the size, location of calculi and analyze roughly the urolithiasis constituents in vivo, especially the appear of dual soure CT, which provide a new method for studying urolithiasis constituents. It may be helpful to find the cause, prevention and therapy of calculi. (authors)

  1. Empirical mode decomposition for analyzing acoustical signals

    Science.gov (United States)

    Huang, Norden E. (Inventor)

    2005-01-01

    The present invention discloses a computer implemented signal analysis method through the Hilbert-Huang Transformation (HHT) for analyzing acoustical signals, which are assumed to be nonlinear and nonstationary. The Empirical Decomposition Method (EMD) and the Hilbert Spectral Analysis (HSA) are used to obtain the HHT. Essentially, the acoustical signal will be decomposed into the Intrinsic Mode Function Components (IMFs). Once the invention decomposes the acoustic signal into its constituting components, all operations such as analyzing, identifying, and removing unwanted signals can be performed on these components. Upon transforming the IMFs into Hilbert spectrum, the acoustical signal may be compared with other acoustical signals.

  2. Electrical aerosol analyzer: calibration and performance

    Energy Technology Data Exchange (ETDEWEB)

    Pui, D.Y.H.; Liu, B.Y.H.

    1976-01-01

    The Electrical Aerosol Analyzer (EAA) was calibrated by means of monodisperse aerosols generated by two independent techniques. In the 0.02 to 1 ..mu..m diameter range, the aerosol was generated by electrostatic classification. In the range between 0.007 and 0.03 ..mu..m, the aerosols were generated by the photo-oxidation of SO/sub 2/ in a smog chamber. Calibration data are presented showing the performance of the EAA as an aerosol detector and as a size distribution analyzer.

  3. BWR plant analyzer development at BNL

    International Nuclear Information System (INIS)

    Cheng, H.S.; Wulff, W.; Mallen, A.N.; Lekach, S.V.; Stritar, A.; Cerbone, R.J.

    1985-01-01

    Advanced technology for high-speed interactive nuclear power plant simulations is of great value for timely resolution of safety issues, for plant monitoring, and for computer-aided emergency responses to an accident. Presented is the methodology employed at BNL to develop a BWR plant analyzer capable of simulating severe plant transients at much faster than real-time process speeds. Five modeling principles are established and a criterion is given for selecting numerical procedures and efficient computers to achieve the very high simulation speeds. Typical results are shown to demonstrate the modeling fidelity of the BWR plant analyzer

  4. Streamlining Policy Creation in Policy Frameworks

    NARCIS (Netherlands)

    M.A. Hills (Mark); N. Martí-Oliet; M. Palomino

    2012-01-01

    textabstract{\\it Policy frameworks} provide a technique for improving reuse in program analysis: the same language frontend, and a core analysis semantics, can be shared among multiple analysis policies for the same language, while analysis domains (such as units of measurement) can be shared among

  5. Economic and Policy Review: Editorial Policies

    African Journals Online (AJOL)

    ... and economic environment in which they operate and work. EPR enlists experts in public policy, business, economic theory and practice to express their thoughts and views in the most influential way possible on economic policy and direction of government and the Nigerian economy in the short, medium and long terms.

  6. Developing policies and procedures.

    Science.gov (United States)

    Randolph, Susan A

    2006-11-01

    The development of policies and procedures is an integral part of the occupational health nurse's role. Policies and procedures serve as the foundation for the occupational health service and are based on its vision, mission, culture, and values. The design and layout selected for the policies and procedures should be simple, consistent, and easy to use. The same format should be used for all existing and new policies and procedures. Policies and procedures should be reviewed periodically based on a specified time frame (i.e., annually). However, some policies may require a more frequent review if they involve rapidly changing external standards, ethical issues, or emerging exposures.

  7. The Policy Design Effect

    DEFF Research Database (Denmark)

    Hedegaard, Troels Fage

    2014-01-01

    Public and individual support for a policy is affected by how it is designed – that is, how eligibility is determined. This results in universal policies being more popular than contributions-based policies, which in turn enjoy more public support than the selective kind. The literature on welfare...... benefits in Denmark shows a large impact on attitudes from being proximate to recipients under selective policies, little or no impact from universal policies and a pattern that falls in-between for the contributions-based policy. This article thus provides micro-level evidence for the different impacts...

  8. Innovation policies for tourism

    DEFF Research Database (Denmark)

    Hjalager, Anne-Mette

    2012-01-01

    The nature, extent, and implications of innovation in tourism are increasingly investigated in academic research, but the policies that affect these transformations in the industry and at tourism destinations are not equally well conceptualised theoretically or analysed empirically. The purpose...... of this article is, in an analysis of the literature, to interpret the rationale behind innovation policy, and to explain the persisting challenges related to acquisition of an informed foundation for policies based upon quantitative and qualitative inquiries. Observed in a historical perspective, innovation...... framework of policy instruments for innovation in tourism. New generations of policies instigate a mainstreaming of the innovation agenda in ways that proceed beyond the traditional policy concepts....

  9. [Energy policy rather than climate policy].

    Science.gov (United States)

    Kroonenberg, Salomon B

    2009-01-01

    Energy policy and climate policy are two different issues and should not be treated as if they were the same. Whether the climate gets warmer or colder, saving energy and developing sustainable forms of energy production remain of paramount importance because fossil hydrocarbons are likely to be exhausted soon. But climate policy is a fallacy: it is human arrogance to think we can control the climate by reducing emissions and by storing CO2 underground. In spite of rising CO2 levels, the climate has cooled down slightly over the past decade. Since the International Panel on Climate Change (IPCC) did not predict this, it is questionable whether they can reliably predict warming. Other factors such as solar activity are probably more important for climate than greenhouse gases. The danger of coupling energy policy to climate policy is evident: if the climate cools down, people will lose belief in the greenhouse effect and therefore also lose interest in saving energy.

  10. How policies affect international biofuel price linkages

    International Nuclear Information System (INIS)

    Rajcaniova, Miroslava; Drabik, Dusan; Ciaian, Pavel

    2013-01-01

    We estimate the role of biofuel policies in determining which country is the price leader in world biofuel markets using a cointegration analysis and a Vector Error Correction (VEC) model. Weekly prices are analyzed for the EU, US, and Brazilian ethanol and biodiesel markets in the 2002–2010 and 2005–2010 time periods, respectively. The US blender's tax credit and Brazil's consumer tax exemption are found to play a role in determining the ethanol prices in other countries. For biodiesel, our results demonstrate that EU policies – the consumer tax exemption and blending target – tend to determine the world biodiesel price. - Highlights: • We estimate the role of biofuel policies in determining biofuel prices. • We use a cointegration analysis and the Vector Error Correction (VEC) model. • The biofuel policies in US and Brazil determine the world ethanol prices. • EU biofuel policies tend to form the world biodiesel price

  11. International Public-private Partnership Policies

    DEFF Research Database (Denmark)

    Greve, Carsten

    This paper focuses on how international public-private partnership (PPP) policies are formulated and implemented by international organizations. PPPs for infrastructure projects are relevant and present in many countries around the world. The literature is full of studies of individual countries...... make policy for PPPs and to focus on perception issues related to their actions. The research questions are: How do international organizations make policy for PPPs and what tools do they use? Do PPP policies from international organizations converge on the same kind of themes? The theoretical lenses...... and various aspects of PPPs governance and finance. But what has been less emphasized in the literature is the way in which international organizations have been developing and promoting policies for PPPs. This paper makes a first attempt in trying to describe and analyze the way international organizations...

  12. Institutional Constraints, Legislative Activism, and Policy Change

    DEFF Research Database (Denmark)

    Citi, Manuele; Justesen, Mogens Kamp

    of regulatory reform in the EU. The rise in the number of legislative proposal, in turn, is affected by the extent of gridlock between the EU’s legislative bodies. These findings show that the Commission steps up its legislative activity when the institutional opportunity space allows for greater policy change.......This paper studies how institutional constraints affect legislative activism, and how legislative activism affects policy change, analyzing the case of the European Union’s legislative process. Our argument revolves around the key role of the Commission in advancing policy change, and emphasizes...... that the Commission can successfully push for increased policy change by increasing its legislative activity when the institutional opportunity space widens. Using a novel panel dataset covering eight policy sectors from 1984--‐2012, we find that the number of legislative proposals significantly affects the extent...

  13. Multiple Environmental Externalities and Manure Management Policy

    OpenAIRE

    Key, Nigel D.; Kaplan, Jonathan D.

    2007-01-01

    This paper considers the economic and environmental implications of regulating water and air nitrogen emissions under single and multi-environmental media policies in the U.S. hog industry. We examine tradeoffs from policies designed to correct an externality in one medium, when there are multiple environmental externalities. We separately and jointly analyze: (a) nitrogen land application restrictions consistent with recently adopted EPA requirements under the Clean Water Act, and (b) hypoth...

  14. Local transportation policy and the environment

    OpenAIRE

    Schmutzler, Armin

    2011-01-01

    The paper introduces a simple framework for analyzing the environmental effects of local transportation policies, and it reviews some evidence. In several cases, subsidies for local public transportation have led to substantial reductions in road transportation and have thereby reduced externalities. Some but not all estimates suggest positive overall welfare effects of such policies. In the rare cases where road pricing has been applied, it has helped to reduce automobile transportation, and...

  15. CULTURAL POLICY IN TRANSITIONAL ECONOMIES: NEW CHALLENGES

    Directory of Open Access Journals (Sweden)

    Ulyana V. SHCHURKO

    2014-06-01

    Full Text Available The article is dedicated to the new conditions of countries’ development in the post-crisis period. Challenges to the cultural and socio-economic policy during last decade were analyzed. Religious factors are offered to be considered as important mechanisms of solving transition period problems, and at the same time as the causes of many conflicts in the world. It was offered to include those factors as inevitable elements into modern policy making process.

  16. Energy issues and policies in Brazil

    International Nuclear Information System (INIS)

    Goldemberg, J.

    1981-10-01

    Initiative taken in Brazil to achieve 'energy autonomy' in vien of the petroleum crisis is analyzed. The dynamics of the movement away from oil and the desire to base the development of the country on locally available resources such as hydroelectricity and biomass derived fuels are emphasized. Energy resources, energy comsumption, issues and policies, energy projections and social issues are discussed, as well as the relevance and applicability to other countries of policies followed in Brazil. (I.C.R.) [pt

  17. INDUSTRIAL POLICY IN THE EUROPEAN UNION

    Directory of Open Access Journals (Sweden)

    Petronela Nica

    2010-06-01

    Full Text Available The differences registered in the early 90s between the economy of the European Union as compared to the economies of the United States and Japan, in regards of growth rates, investment rates, R&D and innovation, international trade, etc., as well as the fast changes of the world economy determined the European Commission to issue the white paper on “Growth, Competitiveness and Employment”, underlining the meaning of the European economy’s competitiveness in the new conditions, and the legal frame for EU’s industrial policy was settled through the Treaty of Maastricht. The document was setting theobjectives, priorities and the six basic principles of the European industrial policy, in a unitary concept. In the spring of 2000, the European Council from Lisbon sets the objective of transforming the European Union in the most dynamic and competitive economy of the world, and, therefore, foresees a working agenda with specific actions going until the horizon of 2009. In December 2002, after EUs enlargement, the Commission forwards to the Council the document titled “Industrial Policy in an Enlarged Europe”, in which theindustrial development at the moment of new member states integration is analyzed, as well as the effects of EU’s enlargement over the industry, and it suggests actions for the future development of the sector. The industrial policy of the EU must offer solutions for industrial development, by answering the challenges concerning globalization, the technological and organizational changes, the increasing role of innovation and entrepreneurship, and the sustainable development taking into consideration the new socialrequirements. The development objectives set at European level cannot be reached without a tight interconnection of the industrial policy measures with those of some complementary policies, such as thecommercial policy, the single market policy, transport and energy policies, research and development policies

  18. Environmental applications of the centrifugal fast analyzer

    International Nuclear Information System (INIS)

    Goldstein, G.; Strain, J.E.; Bowling, J.L.

    1975-12-01

    The centrifugal fast analyzer (GeMSAEC Fast Analyzer) was applied to the analysis of pollutants in air and water. Since data acquisition and processing are computer controlled, considerable effort went into devising appropriate software. A modified version of the standard FOCAL interpreter was developed which includes special machine language functions for data timing, acquisition, and storage, and also permits chaining together of programs stored on a disk. Programs were written and experimental procedures developed to implement spectrophotometric, turbidimetric, kinetic (including initial-rate, fixed-time, and variable-time techniques), and chemiluminescence methods of analysis. Analytical methods were developed for the following elements and compounds: SO 2 , O 3 , Ca, Cr, Cu, Fe, Mg, Se(IV), Zn, Cl - , I - , NO 2 - , PO 4 -3 , S -2 , and SO 4 -2 . In many cases, standard methods could be adapted to the centrifugal analyzer, in others new methods were employed. In general, analyses performed with the centrifugal fast analyzer were faster, more precise, and more accurate than with conventional instrumentation

  19. Fluidization quality analyzer for fluidized beds

    Science.gov (United States)

    Daw, C.S.; Hawk, J.A.

    1995-07-25

    A control loop and fluidization quality analyzer for a fluidized bed utilizes time varying pressure drop measurements. A fast-response pressure transducer measures the overall bed pressure drop, or over some segment of the bed, and the pressure drop signal is processed to produce an output voltage which changes with the degree of fluidization turbulence. 9 figs.

  20. How to Analyze Company Using Social Network?

    Science.gov (United States)

    Palus, Sebastian; Bródka, Piotr; Kazienko, Przemysław

    Every single company or institution wants to utilize its resources in the most efficient way. In order to do so they have to be have good structure. The new way to analyze company structure by utilizing existing within company natural social network and example of its usage on Enron company are presented in this paper.

  1. Analyzing Vessel Behavior Using Process Mining

    NARCIS (Netherlands)

    Maggi, F.M.; Mooij, A.J.; Aalst, W.M.P. van der

    2013-01-01

    In the maritime domain, electronic sensors such as AIS receivers and radars collect large amounts of data about the vessels in a certain geographical area. We investigate the use of process mining techniques for analyzing the behavior of the vessels based on these data. In the context of maritime

  2. Images & Issues: How to Analyze Election Rhetoric.

    Science.gov (United States)

    Rank, Hugh

    Although it is impossible to know in advance the credibility of political messages, such persuasive discourse can be analyzed in a non-partisan, common sense way using predictable patterns in content and form. The content of a candidate's message can be summarized as "I am competent and trustworthy; from me, you'll get 'more good' and 'less…

  3. Thermal and Evolved-Gas Analyzer Illustration

    Science.gov (United States)

    2008-01-01

    This is a computer-aided drawing of the Thermal and Evolved-Gas Analyzer, or TEGA, on NASA's Phoenix Mars Lander. The Phoenix Mission is led by the University of Arizona, Tucson, on behalf of NASA. Project management of the mission is by NASA's Jet Propulsion Laboratory, Pasadena, Calif. Spacecraft development is by Lockheed Martin Space Systems, Denver.

  4. Consideration Regarding Diagnosis Analyze of Corporate Management

    Directory of Open Access Journals (Sweden)

    Mihaela Ciopi OPREA

    2009-01-01

    Full Text Available Diagnosis management aims to identify critical situations and positive aspectsof corporate management. An effective diagnosis made by a team with thestatus of independence from the organization’s management is for managers auseful feedback necessary to improve performance. The work presented focuseson the methodology to achieve effective diagnosis, considering multitudecriteria and variables to be analyzed.

  5. Analyzing and Interpreting Research in Health Education ...

    African Journals Online (AJOL)

    While qualitative research is used when little or nothing is known about the subject, quantitative research is required when there are quantifiable variables to be measured. By implication, health education research is based on phenomenological, ethnographical and/or grounded theoretical approaches that are analyzable ...

  6. Analyzing Languages for Specific Purposes Discourse

    Science.gov (United States)

    Bowles, Hugo

    2012-01-01

    In the last 20 years, technological advancement and increased multidisciplinarity has expanded the range of data regarded as within the scope of languages for specific purposes (LSP) research and the means by which they can be analyzed. As a result, the analytical work of LSP researchers has developed from a narrow focus on specialist terminology…

  7. Automatic radioxenon analyzer for CTBT monitoring

    International Nuclear Information System (INIS)

    Bowyer, T.W.; Abel, K.H.; Hensley, W.K.

    1996-12-01

    Over the past 3 years, with support from US DOE's NN-20 Comprehensive Test Ban Treaty (CTBT) R ampersand D program, PNNL has developed and demonstrated a fully automatic analyzer for collecting and measuring the four Xe radionuclides, 131m Xe(11.9 d), 133m Xe(2.19 d), 133 Xe (5.24 d), and 135 Xe(9.10 h), in the atmosphere. These radionuclides are important signatures in monitoring for compliance to a CTBT. Activity ratios permit discriminating radioxenon from nuclear detonation and that from nuclear reactor operations, nuclear fuel reprocessing, or medical isotope production and usage. In the analyzer, Xe is continuously and automatically separated from the atmosphere at flow rates of about 7 m 3 /h on sorption bed. Aliquots collected for 6-12 h are automatically analyzed by electron-photon coincidence spectrometry to produce sensitivities in the range of 20-100 μBq/m 3 of air, about 100-fold better than with reported laboratory-based procedures for short time collection intervals. Spectral data are automatically analyzed and the calculated radioxenon concentrations and raw gamma- ray spectra automatically transmitted to data centers

  8. Performance optimization of spectroscopic process analyzers

    NARCIS (Netherlands)

    Boelens, Hans F. M.; Kok, Wim Th; de Noord, Onno E.; Smilde, Age K.

    2004-01-01

    To increase the power and the robustness of spectroscopic process analyzers, methods are needed that suppress the spectral variation that is not related to the property of interest in the process stream. An approach for the selection of a suitable method is presented. The approach uses the net

  9. ITK and ANALYZE: a synergistic integration

    Science.gov (United States)

    Augustine, Kurt E.; Holmes, David R., III; Robb, Richard A.

    2004-05-01

    The Insight Toolkit (ITK) is a C++ open-source software toolkit developed under sponsorship of the National Library of Medicine. It provides advanced algorithms for performing image registration and segmentation, but does not provide support for visualization and analysis, nor does it offer any graphical user interface (GUI). The purpose of this integration project is to make ITK readily accessible to end-users with little or no programming skills, and provide interactive processing, visualization and measurement capabilities. This is achieved through the integration of ITK with ANALYZE, a multi-dimension image visualization/analysis application installed in over 300 institutions around the world, with a user-base in excess of 4000. This integration is carried out at both the software foundation and GUI levels. The foundation technology upon which ANALYZE is built is a comprehensive C-function library called AVW. A new set of AVW-ITK functions have been developed and integrated into the AVW library, and four new ITK modules have been added to the ANALYZE interface. Since ITK is a software developer"s toolkit, the only way to access its intrinsic power is to write programs that incorporate it. Integrating ITK with ANALYZE opens the ITK algorithms to end-users who otherwise might never be able to take advantage of the toolkit"s advanced functionality. In addition, this integration provides end-to-end interactive problem solving capabilities which allow all users, including programmers, an integrated system to readily display and quantitatively evaluate the results from the segmentation and registration routines in ITK, regardless of the type or format of input images, which are comprehensively supported in ANALYZE.

  10. Genetic non-discrimination policy in Canada: Assessing windows of opportunity for policy change.

    Science.gov (United States)

    Caggiano, Adriana V; Al Kindi, Said Y; Randall, Glen E

    2017-11-01

    As the ease of obtaining genetic information for both the diagnosis and treatment of diseases has become increasingly common, so have concerns about the misuse of such information. The obstacles Canada faces in adopting genetic non-discrimination legislation have left health leaders with a lack of clear direction. Using the Kingdon agenda-setting framework, this article will identify lost opportunities for policy change and will analyze the potential for the adoption of a genetic non-discrimination policy in Canada. Windows of opportunity for policy change have existed in the past, but these windows have closed prior to a policy being adopted. More recently, the alignment of problem, policy, and politics streams in the agenda-setting process has resulted in a new window of opportunity. The adoption of a clear and coherent policy will provide the public with protection and health leaders with greater direction around genetic information.

  11. The social policies of Lula's administration

    Directory of Open Access Journals (Sweden)

    Maria Hermínia Tavares de Almeida

    Full Text Available The article focuses on the initiatives taken by the Lula administration regarding social policies. To begin with, we describe the social reform process implemented by the governments that followed the redemocratization of Brazil. Then, we examine some indices showing the evolution of social conditions due to social policies practiced during the democratic period. Finally, we analyze the views about the social question predominant in the PT government, as well as the most appropriate policies to tackle such a question. We also discuss the present government's proposals and initiatives regarding the social area.

  12. Disability pensions and active labour market policy

    DEFF Research Database (Denmark)

    Caswell, Dorte; Kleif, Helle Bendix

    2013-01-01

    Danish active labor market policy, under the headline of flexicurity, has received international attention due to its claimed ability to curb unemployment while boosting employment. A strong belief in the positive effects of activation, in policy as well as practice, has had consequences for all...... client types, including those who are far from labor market participation due to social, mental, physical, or other problems. We analyze the application of active labor market policy measures used to support clients with substantial problems besides unemployment. This study utilizes Danish register data...

  13. Dor lateral no joelho do atleta: um raro caso de luxação do tendão do bíceps femoral Lateral pain in an athlete's knee: a rare case of dislocation of the femoral biceps tendon

    Directory of Open Access Journals (Sweden)

    Aires Duarte Junior

    2012-01-01

    Full Text Available A luxação do tendão do bíceps femoral é uma condição rara, descrita na literatura clinicamente com uma dor lateral do joelho e inicialmente relatada como uma inserção anômala da cabeça longa do bíceps femoral. Depois se verificou que a causa é uma mobilidade anormal do tendão sobre a proeminência da cabeça da fíbula em determinados ângulos de flexão do joelho. O objetivo deste relato de caso raro é descrever e discutir sobre o quadro de dor lateral no joelho num atleta de natação que iniciou a subluxação do bíceps femoral durante a prática esportiva, que o incapacitava de realizar provas e torneios. O caso é discutido frente à literatura levantada, à provável etiologia traumática de repetição que levou a essa condição, além do tratamento cirúrgico que foi realizado, obtendo excelente resultado e retorno a prática esportiva habitual.Dislocation of the femoral biceps tendon is rare and is described clinically in the literature as a lateral pain in the knee. It was initially reported as an anomalous insertion of the long head of the femoral biceps. Subsequently, it was found to be caused by abnormal mobility of the tendon over the prominence of the fibu lar head at certain angles of knee flexion. The objective of the present report was to describe and discuss a condition of lateral knee pain in a swimmer who started to present subluxation of the femoral biceps during sports practice, which incapacitated him from taking part in trials and competitions. The case is dis cussed in the light of the literature surveyed; the likelihood that the etiology for the trauma leading to this condition was repeti tion; and the surgical treatment instituted, which led to excellent results and the patient's return to his habitual sports practice.

  14. Nordic cultural policies

    DEFF Research Database (Denmark)

    Duelund, Peter

    2008-01-01

    A critical view on Nordic Cultural Policy 1961-2008 - Aims, measures, forms of organisation, state og national identity......A critical view on Nordic Cultural Policy 1961-2008 - Aims, measures, forms of organisation, state og national identity...

  15. IT Policy Archive

    Data.gov (United States)

    National Aeronautics and Space Administration — CIO defines IT processes and policies. The CIO defines the development processes, milestones, review gates, and the overall policies for all capital planning,...

  16. National Environmental Policy Act

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The National Environmental Policy Act (NEPA) was the first major environmental law in the United States and established national environmental policies for the...

  17. Methodology for analyzing risk at nuclear facilities

    International Nuclear Information System (INIS)

    Yoo, Hosik; Lee, Nayoung; Ham, Taekyu; Seo, Janghoon

    2015-01-01

    Highlights: • A new methodology for evaluating the risk at nuclear facilities was developed. • Five measures reflecting all factors that should be concerned to assess risk were developed. • The attributes on NMAC and nuclear security culture are included as attributes for analyzing. • The newly developed methodology can be used to evaluate risk of both existing facility and future nuclear system. - Abstract: A methodology for evaluating risks at nuclear facilities is developed in this work. A series of measures is drawn from the analysis of factors that determine risks. Five measures are created to evaluate risks at nuclear facilities. These include the legal and institutional framework, material control, physical protection system effectiveness, human resources, and consequences. Evaluation attributes are developed for each measure and specific values are given in order to calculate the risk value quantitatively. Questionnaires are drawn up on whether or not a state has properly established a legal and regulatory framework (based on international standards). These questionnaires can be a useful measure for comparing the status of the physical protection regime between two countries. Analyzing an insider threat is not an easy task and no methodology has been developed for this purpose. In this study, attributes that could quantitatively evaluate an insider threat, in the case of an unauthorized removal of nuclear materials, are developed by adopting the Nuclear Material Accounting & Control (NMAC) system. The effectiveness of a physical protection system, P(E), could be analyzed by calculating the probability of interruption, P(I), and the probability of neutralization, P(N). In this study, the Tool for Evaluating Security System (TESS) code developed by KINAC is used to calculate P(I) and P(N). Consequence is an important measure used to analyze risks at nuclear facilities. This measure comprises radiological, economic, and social damage. Social and

  18. Hybrid Security Policies

    Directory of Open Access Journals (Sweden)

    Radu CONSTANTINESCU

    2006-01-01

    Full Text Available Policy is defined as the rules and regulations set by the organization. They are laid down by management in compliance with industry regulations, law and internal decisions. Policies are mandatory. Security policies rules how the information is protected against security vulnerabilities and they are the basis for security awareness, training and vital for security audits. Policies are focused on desired results. The means of achieving the goals are defined on controls, standards and procedures.

  19. Innovation policies for tourism

    DEFF Research Database (Denmark)

    Hjalager, Anne-Mette

    2012-01-01

    The nature, extent, and implications of innovation in tourism are increasingly investigated in academic research, but the policies that affect these transformations in the industry and at tourism destinations are not equally well conceptualised theoretically or analysed empirically. The purpose...... framework of policy instruments for innovation in tourism. New generations of policies instigate a mainstreaming of the innovation agenda in ways that proceed beyond the traditional policy concepts....

  20. Economics and obesity policy.

    Science.gov (United States)

    Lusk, J L

    2017-06-01

    This paper elucidates the challenges surrounding the economics of some popular obesity-related policy proposals. Solid economic justifications for anti-obesity policies are often lacking, and evidence suggests policies like fat and soda taxes or restrictions on food stamp spending are unlikely to substantively affect obesity prevalence. In short, many of the same factors that make obesity such a complicated and multifaceted issue extend to the economic analysis of public health policies.

  1. Modeling extreme ultraviolet suppression of electrostatic analyzers

    International Nuclear Information System (INIS)

    Gershman, Daniel J.; Zurbuchen, Thomas H.

    2010-01-01

    In addition to analyzing energy-per-charge ratios of incident ions, electrostatic analyzers (ESAs) for spaceborne time-of-flight mass spectrometers must also protect detectors from extreme ultraviolet (EUV) photons from the Sun. The required suppression rate often exceeds 1:10 7 and is generally established in tests upon instrument design and integration. This paper describes a novel technique to model the EUV suppression of ESAs using photon ray tracing integrated into SIMION, the most commonly used ion optics design software for such instruments. The paper compares simulation results with measurements taken from the ESA of the Mass instrument flying onboard the Wind spacecraft. This novel technique enables an active inclusion of EUV suppression requirements in the ESA design process. Furthermore, the simulation results also motivate design rules for such instruments.

  2. Real-time airborne particle analyzer

    Science.gov (United States)

    Reilly, Peter T.A.

    2012-10-16

    An aerosol particle analyzer includes a laser ablation chamber, a gas-filled conduit, and a mass spectrometer. The laser ablation chamber can be operated at a low pressure, which can be from 0.1 mTorr to 30 mTorr. The ablated ions are transferred into a gas-filled conduit. The gas-filled conduit reduces the electrical charge and the speed of ablated ions as they collide and mix with buffer gases in the gas-filled conduit. Preferably, the gas filled-conduit includes an electromagnetic multipole structure that collimates the nascent ions into a beam, which is guided into the mass spectrometer. Because the gas-filled conduit allows storage of vast quantities of the ions from the ablated particles, the ions from a single ablated particle can be analyzed multiple times and by a variety of techniques to supply statistically meaningful analysis of composition and isotope ratios.

  3. Analyzing Technique of Power Systems Under Deregulation

    Science.gov (United States)

    Miyauchi, Hajime; Kita, Hiroyuki; Ishigame, Atsushi

    Deregulation of the electric utilities has been progressing. Even under the deregulation, the reliability should be the most important problem of power systems. However, according to the deregulation, operation and scheduling of power systems are changing and new techniques to analyze power systems are introducing. To evaluate reliability of power systems, adequacy and security are well employed recently. This paper presents the new analyzing technique which will be realized in near future from the viewpoint of adequacy and security. First, simulation tool to evaluate adequacy is described. As an example of this tool, MARS and other methods are mentioned. Next, to evaluate the security, security constrained unit commitment (SCUC) and security constrained optimal power flow (SCOPF) are mentioned. Finally, some topics concerning ancillary service are described.

  4. Development of a nuclear plant analyzer (NPA)

    International Nuclear Information System (INIS)

    De Vlaminck, M.; Mampaey, L.; Vanhoenacker, L.; Bastenaire, F.

    1990-01-01

    A Nuclear Plant Analyzer has been developed by TRACTABEL. Three distinct functional units make up the Nuclear Plant Analyser, a model builder, a run time unit and an analysis unit. The model builder is intended to build simulation models which describe on the one hand the geometric structure and initial conditions of a given plant and on the other hand command control logics and reactor protection systems. The run time unit carries out dialog between the user and the thermal-hydraulic code. The analysis unit is aimed at deep analyzing of the transient results. The model builder is being tested in the framework of the International Standard Problem ISP-26, which is the simulation of a LOCA on the Japanese ROSA facility

  5. Computer-based radionuclide analyzer system

    International Nuclear Information System (INIS)

    Ohba, Kengo; Ishizuka, Akira; Kobayashi, Akira; Ohhashi, Hideaki; Tsuruoka, Kimitoshi.

    1978-01-01

    The radionuclide analysis in nuclear power plants, practiced for the purpose of monitoring the quality of the primary loop water, the confirmation of the performance of reactor cleanup system and monitoring the radioactive waste effluent, is an important job. Important as it is, it requires considerable labor of experts, because the samples to be analyzed are multifarious and very large in number, and in addition, this job depends much on manual work. With a view of saving the labor, simplifying and standardizing the work, reducing radiation exposure, and automatizing the work of analysis, the computerized analyzer system has been worked out. The results of its performance test at the operating power plant have proved that the development has fairly accomplished the objects and that the system is well useful. The developmental work was carried out by the cooperation between The Tokyo Electric Power Co. and Toshiba in about 4 years from 1974 to this year. (auth.)

  6. Analyzing the Existing Undergraduate Engineering Leadership Skills

    OpenAIRE

    Hamed M. Almalki; Luis Rabelo; Charles Davis; Hammad Usmani; Debra Hollister; Alfonso Sarmiento

    2016-01-01

    Purpose: Studying and analyzing the undergraduate engineering students' leadership skills to discover their potential leadership strengths and weaknesses. This study will unveil potential ways to enhance the ways we teach engineering leadership. The research has great insights that might assist engineering programs to improve curricula for the purpose of better engineering preparation to meet industry's demands. Methodology and Findings: 441 undergraduate engineering students have been s...

  7. Analyzing negative ties in social networks

    Directory of Open Access Journals (Sweden)

    Mankirat Kaur

    2016-03-01

    Full Text Available Online social networks are a source of sharing information and maintaining personal contacts with other people through social interactions and thus forming virtual communities online. Social networks are crowded with positive and negative relations. Positive relations are formed by support, endorsement and friendship and thus, create a network of well-connected users whereas negative relations are a result of opposition, distrust and avoidance creating disconnected networks. Due to increase in illegal activities such as masquerading, conspiring and creating fake profiles on online social networks, exploring and analyzing these negative activities becomes the need of hour. Usually negative ties are treated in same way as positive ties in many theories such as balance theory and blockmodeling analysis. But the standard concepts of social network analysis do not yield same results in respect of each tie. This paper presents a survey on analyzing negative ties in social networks through various types of network analysis techniques that are used for examining ties such as status, centrality and power measures. Due to the difference in characteristics of flow in positive and negative tie networks some of these measures are not applicable on negative ties. This paper also discusses new methods that have been developed specifically for analyzing negative ties such as negative degree, and h∗ measure along with the measures based on mixture of positive and negative ties. The different types of social network analysis approaches have been reviewed and compared to determine the best approach that can appropriately identify the negative ties in online networks. It has been analyzed that only few measures such as Degree and PN centrality are applicable for identifying outsiders in network. For applicability in online networks, the performance of PN measure needs to be verified and further, new measures should be developed based upon negative clique concept.

  8. Analyzing Architecture of Mithraism Rock Temples

    OpenAIRE

    Zohre AliJabbari

    2017-01-01

    This analyzes the architecture of rock temples of West and Northwest of Iran, as well as factors influencing their formation. The creation of rock architecture in this area of Iran is influenced by the religious, geographical and political atmosphere of their time. Most of these structures are formed by dominated empires in the first millennium BC. And in some works we are observing their continuity in later periods and change in their functions. One of the reasons that have attracted man to ...

  9. General methods for analyzing bounded proportion data

    OpenAIRE

    Hossain, Abu

    2017-01-01

    This thesis introduces two general classes of models for analyzing proportion response variable when the response variable Y can take values between zero and one, inclusive of zero and/or one. The models are inflated GAMLSS model and generalized Tobit GAMLSS model. The inflated GAMLSS model extends the flexibility of beta inflated models by allowing the distribution on (0,1) of the continuous component of the dependent variable to come from any explicit or transformed (i.e. logit or truncated...

  10. Development of a Portable Water Quality Analyzer

    OpenAIRE

    Germán COMINA; Martin NISSFOLK; José Luís SOLÍS

    2010-01-01

    A portable water analyzer based on a voltammetric electronic tongue has been developed. The system uses an electrochemical cell with two working electrodes as sensors, a computer controlled potentiostat, and software based on multivariate data analysis for pattern recognition. The system is suitable to differentiate laboratory made and real in-situ river water samples contaminated with different amounts of Escherichia coli. This bacteria is not only one of the main indicators for water qualit...

  11. Moving Block Bootstrap for Analyzing Longitudinal Data.

    Science.gov (United States)

    Ju, Hyunsu

    In a longitudinal study subjects are followed over time. I focus on a case where the number of replications over time is large relative to the number of subjects in the study. I investigate the use of moving block bootstrap methods for analyzing such data. Asymptotic properties of the bootstrap methods in this setting are derived. The effectiveness of these resampling methods is also demonstrated through a simulation study.

  12. A chemical analyzer for charged ultrafine particles

    OpenAIRE

    S. G. Gonser; A. Held

    2013-01-01

    New particle formation is a frequent phenomenon in the atmosphere and of major significance for the earth's climate and human health. To date the mechanisms leading to the nucleation of particles as well as to aerosol growth are not completely understood. A lack of appropriate measurement equipment for online analysis of the chemical composition of freshly nucleated particles is one major limitation. We have developed a Chemical Analyzer for Charged Ultrafine Particles (CAChUP) capable...

  13. A chemical analyzer for charged ultrafine particles

    OpenAIRE

    S. G. Gonser; A. Held

    2013-01-01

    New particle formation is a frequent phenomenon in the atmosphere and of major significance for the Earth's climate and human health. To date the mechanisms leading to the nucleation of particles as well as to aerosol growth are not completely understood. A lack of appropriate measurement equipment for online analysis of the chemical composition of freshly nucleated particles is one major limitation. We have developed a Chemical Analyzer for Charged Ultrafine Particles (CAChUP) capable of ana...

  14. A seal analyzer for testing container integrity

    International Nuclear Information System (INIS)

    McDaniel, P.; Jenkins, C.

    1988-01-01

    This paper reports on the development of laboratory and production seal analyzer that offers a rapid, nondestructive method of assuring the seal integrity of virtually any type of single or double sealed container. The system can test a broad range of metal cans, drums and trays, membrane-lidded vessels, flexible pouches, aerosol containers, and glass or metal containers with twist-top lids that are used in the chemical/pesticide (hazardous materials/waste), beverage, food, medical and pharmaceutical industries

  15. Information decomposition method to analyze symbolical sequences

    International Nuclear Information System (INIS)

    Korotkov, E.V.; Korotkova, M.A.; Kudryashov, N.A.

    2003-01-01

    The information decomposition (ID) method to analyze symbolical sequences is presented. This method allows us to reveal a latent periodicity of any symbolical sequence. The ID method is shown to have advantages in comparison with application of the Fourier transformation, the wavelet transform and the dynamic programming method to look for latent periodicity. Examples of the latent periods for poetic texts, DNA sequences and amino acids are presented. Possible origin of a latent periodicity for different symbolical sequences is discussed

  16. Neutral Particle Analyzer Diagnostic on NSTX

    Energy Technology Data Exchange (ETDEWEB)

    S.S. Medley; A.L. Roquemore

    2004-03-16

    The Neutral Particle Analyzer (NPA) diagnostic on the National Spherical Torus Experiment (NSTX) utilizes a PPPL-designed E||B spectrometer that measures the energy spectra of minority hydrogen and bulk deuterium species simultaneously with 39 energy channels per mass specie and a time resolution of 1 ms. The calibrated energy range is E = 0.5-150 keV and the energy resolution varies from AE/E = 3-7% over the surface of the microchannel plate detector.

  17. Neutral Particle Analyzer Diagnostic on NSTX

    International Nuclear Information System (INIS)

    Medley, S.S.; Roquemore, A.L.

    2004-01-01

    The Neutral Particle Analyzer (NPA) diagnostic on the National Spherical Torus Experiment (NSTX) utilizes a PPPL-designed E||B spectrometer that measures the energy spectra of minority hydrogen and bulk deuterium species simultaneously with 39 energy channels per mass specie and a time resolution of 1 ms. The calibrated energy range is E = 0.5-150 keV and the energy resolution varies from AE/E = 3-7% over the surface of the microchannel plate detector

  18. Performance of national policies

    NARCIS (Netherlands)

    Lange, M. de; Mastop, H.; Spit, T.

    1997-01-01

    National spatial policies are usually indicative and strategic. As a result, this kind of policy does not have a direct bearing on the spatial organisation of society. Instead the performance of these policies depends on whether or not they are used in subsequent decisionmaking and planning

  19. Italian energy policy

    International Nuclear Information System (INIS)

    1988-01-01

    This document discusses problems associated with Italian energy policy; economic and industrial development as it relates to that policy is covered. Specific areas covered are: (1) the basis of Italy's new energy policy; (2) energy demand; (3) five objectives; (4) the electrical power system; (5) proposed action; and (6) energy resources

  20. Quarterly fiscal policy

    NARCIS (Netherlands)

    Kendrick, D.A.; Amman, H.M.

    2014-01-01

    Monetary policy is altered once a month. Fiscal policy is altered once a year. As a potential improvement this article examines the use of feedback control rules for fiscal policy that is altered quarterly. Following the work of Blinder and Orszag, modifications are discussed in Congressional

  1. Single Policy Study

    DEFF Research Database (Denmark)

    Kronsell, Annica; Manners, Ian James

    2015-01-01

    Single policy studies are the most common form of European Union (EU) research. Single policy studies are widely used to understand the role of the EU in a wide variety of sectors, together with their development over time, and often offer public policy prescriptions. This chapter discusses the r...... Policy (CSDP). The examples are illustrative of how single policy studies can be designed to use different approaches in the analysis: multiple streams approach to policy-making; a comparative hypothesis testing; and feminist institutional theory.......Single policy studies are the most common form of European Union (EU) research. Single policy studies are widely used to understand the role of the EU in a wide variety of sectors, together with their development over time, and often offer public policy prescriptions. This chapter discusses...... the relevance of single policy studies in EU research and give examples of how such research can be designed and carried out. The chapter reviews three examples of single policy studies using different methods based on EU environmental policy, the EU biofuels directive, and the EU Common Security and Defence...

  2. A Raman-Based Portable Fuel Analyzer

    Science.gov (United States)

    Farquharson, Stuart

    2010-08-01

    Fuel is the single most import supply during war. Consider that the US Military is employing over 25,000 vehicles in Iraq and Afghanistan. Most fuel is obtained locally, and must be characterized to ensure proper operation of these vehicles. Fuel properties are currently determined using a deployed chemical laboratory. Unfortunately, each sample requires in excess of 6 hours to characterize. To overcome this limitation, we have developed a portable fuel analyzer capable of determine 7 fuel properties that allow determining fuel usage. The analyzer uses Raman spectroscopy to measure the fuel samples without preparation in 2 minutes. The challenge, however, is that as distilled fractions of crude oil, all fuels are composed of hundreds of hydrocarbon components that boil at similar temperatures, and performance properties can not be simply correlated to a single component, and certainly not to specific Raman peaks. To meet this challenge, we measured over 800 diesel and jet fuels from around the world and used chemometrics to correlate the Raman spectra to fuel properties. Critical to the success of this approach is laser excitation at 1064 nm to avoid fluorescence interference (many fuels fluoresce) and a rugged interferometer that provides 0.1 cm-1 wavenumber (x-axis) accuracy to guarantee accurate correlations. Here we describe the portable fuel analyzer, the chemometric models, and the successful determination of these 7 fuel properties for over 100 unknown samples provided by the US Marine Corps, US Navy, and US Army.

  3. Thermo Scientific Sulfur Dioxide Analyzer Instrument Handbook

    Energy Technology Data Exchange (ETDEWEB)

    Springston, S. R. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2016-03-01

    The Sulfur Dioxide Analyzer measures sulfur dioxide based on absorbance of UV light at one wavelength by SO2 molecules which then decay to a lower energy state by emitting UV light at a longer wavelength. Specifically, SO2 + hυ1 →SO2 *→SO2 + hυ2 The emitted light is proportional to the concentration of SO2 in the optical cell. External communication with the analyzer is available through an Ethernet port configured through the instrument network of the AOS systems. The Model 43i-TLE is part of the i-series of Thermo Scientific instruments. The i-series instruments are designed to interface with external computers through the proprietary Thermo Scientific iPort Software. However, this software is somewhat cumbersome and inflexible. BNL has written an interface program in National Instruments LabView that both controls the Model 43i-TLE Analyzer AND queries the unit for all measurement and housekeeping data. The LabView vi (the software program written by BNL) ingests all raw data from the instrument and outputs raw data files in a uniform data format similar to other instruments in the AOS and described more fully in Section 6.0 below.

  4. Visual analyzer as anticipatory system (functional organization)

    Science.gov (United States)

    Kirvelis, Dobilas

    2000-05-01

    Hypothetical functional organization of the visual analyzer is presented. The interpretation of visual perception, anatomic and morphological structure of visual systems of animals, neuro-physiological, psychological and psycho-physiological data in the light of a number of the theoretical solutions of image recognition and visual processes simulation enable active information processing. The activities in special areas of cortex are as follows: focused attention, prediction with analysis of visual scenes and synthesis, predictive mental images. In the projection zone of visual cortex Area Streata or V1 a "sensory" screen (SS) and "reconstruction" screen (RS) are supposed to exist. The functional structure of visual analyzer consist of: analysis of visual scenes projected onto SS; "tracing" of images; preliminary recognition; reversive image reconstruction onto RS; comparison of images projected onto SS with images reconstructed onto RS; and "correction" of preliminary recognition. Special attention is paid to the quasiholographical principles of the neuronal organization within the brain, of the image "tracing," and of reverse image reconstruction. Tachistoscopic experiments revealed that the duration of one such hypothesis-testing cycle of the human visual analyzers is about 8-10 milliseconds.

  5. THE ROMANIAN ASPECT OF THE E.U. GOVERNANCE CASE STUDIES: EDUCATUION POLICY AND ENVIRONMENTAL POLICY

    Directory of Open Access Journals (Sweden)

    OANA-ANDREEA ION

    2011-04-01

    Full Text Available This paper belongs to the domestic studies which try to connect the Romanian research to the current debates within the EU studies. The authors' aim is to analyze the aspects and the implications of the EU governance at the Member States' domestic policies level, as most of these policies are currently facing the challenges brought by the Europeanization process. Therefore, the theoretical framework selected is the theory of governance, focusing on the explanatory and analytical opportunities of two components – multi-level governance and governance networks; in this way, it is underlined the separation from the classic model of relation between the (multiplied levels of political authority (supranational, national, subnational and the exponential increase in the number and types of actors participating at the decisional process and implementation of European public policy. Within the selected case studies (environmental policy and education policy, the authors advance a research structure with the aims (a to identify the relevant actors involved in the policy-making process of these policies, at all stages of its cycle; (b to offer an explanation of the types of interactions between these actors, and (c to identify the influence these interactions exert on the communitarization pronounced tendency of some EU policy sectors. The analysis is performed in terms of the Treaty of Lisbon (the selected policies being part of distinct categories of the Union competences and it is oriented towards the national level of the making process of these policies.

  6. Implementing Health Policy: Lessons from the Scottish Well Men's Policy Initiative.

    Science.gov (United States)

    Douglas, Flora; van Teijlingen, Edwin; Smith, Cairns; Moffat, Mandy

    2015-01-01

    Little is known about how health professionals translate national government health policy directives into action. This paper examines that process using the so-called Well Men's Services (WMS) policy initiative as a 'real world' case study. The WMS were launched by the Scottish Government to address men's health inequalities. Our analysis aimed to develop a deeper understanding of policy implementation as it naturally occurred, used an analytical framework that was developed to reflect the 'rational planning' principles health professionals are commonly encouraged to use for implementation purposes. A mixed-methods qualitative enquiry using a data archive generated during the WMS policy evaluation was used to critically analyze (post hoc) the perspectives of national policy makers, and local health and social care professionals about the: (a) 'policy problem', (b) interventions intended to address the problem, and (c) anticipated policy outcomes. This analysis revealed four key themes: (1) ambiguity regarding the policy problem and means of intervention; (2) behavioral framing of the policy problem and intervention; (3) uncertainty about the policy evidence base and outcomes, and; (4) a focus on intervention as outcome . This study found that mechanistic planning heuristics (as a means of supporting implementation) fails to grapple with the indeterminate nature of population health problems. A new approach to planning and implementing public health interventions is required that recognises the complex and political nature of health problems; the inevitability of imperfect and contested evidence regarding intervention, and, future associated uncertainties.

  7. Analyzing the outcomes of health promotion practices.

    Science.gov (United States)

    Pereira Lima, Vera Lucia Góes; Arruda, José Maria; Barroso, Maria Auxiliadora Bessa; Lobato Tavares, Maria de Fátima; Ribeiro Campos, Nora Zamith; Zandonadil, Regina Celi Moreira Basílio; da Rocha, Rosa Maria; Parreira, Clélia Maria de Souza Ferreira; Cohen, Simone Cynamon; Kligerman, Débora Cynamon; Sperandio, Ana Maria Girotti; Correa, Carlos Roberto Silveira; Serrano, Miguel Malo

    2007-01-01

    This article focuses on health promotion (HP) outcomes, illustrated through evaluation of case studies and identification of strategies which have contributed to their success and sustainability. Evaluation research and practice in three distinct sceneries are discussed: (i) institutional and governmental agencies; (ii) communities in the "Manguinhos Complex" and Nova Iguaqu Municipality, and (iii) building of potentially healthy municipality networks. The effectiveness of a social program in a health promotion perspective was based in the "School for Parents" program, undertaken by the First Court of Childhood and Youth of Rio de Janeiro, between 2001 and 2004. The analysis was grounded in the monitoring of 48 parents in charge of children under 18, who were victims of abuse, violence or negligence, and social exclusion, most of all. The study's objectives were: illustrating the evidence of effectiveness of health promotion, discussing the concept of HP effectiveness under macro unfavorable conditions, and identifying strategies that foster sustainability of results. Institutional resources included a multi-professional staff, multidisciplinary approaches, participatory workshops, family case management, partnership with public and private institutions, and volunteer and civil society sponsorship of the families. Evaluation was based on social impact indicators, and psychosocial and contextual determinants. Evaluation methods included program monitoring and quantitative-qualitative methods, through a longitudinal evaluation of 3 years, including one year post program. The evaluation showed highly favorable results concerning "family integration', "quality of family relations" and "human rights mobilization". Unsatisfactory results such as "lack of access to formal employment" are likely related to structural factors and the need for new public policies in areas such as education, professional training, housing, and access to formal employment. The training process

  8. Analyzing Variability in Ebola-Related Controls Applied to Returned Travelers in the United States.

    Science.gov (United States)

    Kraemer, John D; Siedner, Mark J; Stoto, Michael A

    2015-01-01

    Public health authorities have adopted entry screening and subsequent restrictions on travelers from Ebola-affected West African countries as a strategy to prevent importation of Ebola virus disease (EVD) cases. We analyzed international, federal, and state policies-principally based on the policy documents themselves and media reports-to evaluate policy variability. We employed means-ends fit analysis to elucidate policy objectives. We found substantial variation in the specific approaches favored by WHO, CDC, and various American states. Several US states impose compulsory quarantine on a broader range of travelers or require more extensive monitoring than recommended by CDC or WHO. Observed differences likely partially resulted from different actors having different policy goals-particularly the federal government having to balance foreign policy objectives less salient to states. Further, some state-level variation appears to be motivated by short-term political goals. We propose recommendations to improve future policies, which include the following: (1) actors should explicitly clarify their objectives, (2) legal authority should be modernized and clarified, and (3) the federal government should consider preempting state approaches that imperil its goals.

  9. Analyzing the impact of human capital factors on competitivenes

    Directory of Open Access Journals (Sweden)

    Óhegyi Katalin

    2014-01-01

    Full Text Available There are a number of approaches to measure national competitiveness. However, in these reports human capital typically appears indirectly. The author's purpose is to uncover how human capital contributes to competitiveness of economies and to propose an approach to identify the most effective improvement opportunities for countries, illustrated on the example of Hungary. The analysis is based on the data of the Global Talent Index Report (2011 and the Global Competitiveness Report 2012-2013. The components of the Global Talent Index (GTI and their relation to the Global Competitiveness Index (GCI were analyzed with a linear programming based similarity analysis method, component-based object comparison for objectivity (COCO. Based on the output of the analysis it was identified how sensitive the Global Competitiveness Index is to the components of the GTI. Hungary's position was analyzed further to quantify improvement opportunities and threats based on the step function resulted by the COCO analysis. The author concludes that the human resource of a country is a pivotal element of national competitiveness. By developing human capital of the country the overall competitive position may be improved. Areas of priorities may be identified and the level of intervention may be quantified specific to a country. This could help policy makers to decide in the allocation of resource to maximize effectiveness, leading to improve (or protect a country's overall competitive position in the global arena.

  10. Influência do calçado de salto alto na atividade eletromiográfica do músculo quadríceps em mulheres com e sem síndrome da dor femoropatelar durante a tarefa de levantar e sentar Influencia del calzado de tacón alto en la actividad electromiográfica del músculo cuádriceps en mujeres con y sin síndrome de dolor patelofemoral durante la tarea de levantarse y sentarse Influence of high-heeled shoes on the quadriceps electromyographic activity in women with and without patellofemoral pain syndrome during the sit-to-stand task

    Directory of Open Access Journals (Sweden)

    Laísla da Silva Paixão Batista

    2013-03-01

    Full Text Available O objetivo do estudo foi analisar a influência do calçado de salto alto na atividade eletromiográfica (EMG do músculo quadríceps durante a tarefa de sentar e levantar. Participaram deste estudo 10 voluntárias assintomáticas com 20,2±3,0 anos e 10 voluntárias com síndrome da dor femoropatelar (SDFP com 21,3±3,4 anos. As voluntárias executaram a tarefa de sentar e levantar em 3 diferentes condições: descalças, com tênis e com calçado de salto de 10 cm. A atividade EMG do vasto medial oblíquo (VMO, vasto lateral (VL e reto femoral (RF foi registrada durante a execução das tarefas por meio de eletrodos de superfície simples diferencial conectados ao eletromiógrafo. Para comparação entre grupos e tarefas, foi utilizado o teste ANOVA com medidas repetidas e o post hoc do teste de Tukey (pEl objetivo del estudio fue analizar la influencia del calzado de tacón alto en la actividad electromiográfica (EMG del músculo cuadríceps durante la tarea de sentarse y levantarse. Participaron de este estudio 10 voluntarias asintomáticas con 20,2±3,0 años y 10 voluntarias con síndrome de dolor patelofemoral (SDPF con 21,3±3,4 años. Las voluntarias ejecutaron la tarea de sentarse y levantarse en tres diferentes condiciones: descalzas, con zapatillas y con calzado de tacón de diez centímetros. La actividad EMG del vasto medial oblícuo (VMO, vasto lateral (VL y recto femoral (RF fue registrada durante la ejecución de las tareas por medio de electrodos de superficie diferenciales conectados al electromiógrafo. Para la comparación entre grupos y tareas fue utilizada la prueba ANOVA con medidas repetidas y post test de Tukey (pThe purpose of this study was to analyze the influence of high-heeled shoes on the quadriceps electromyographic activity (EMG during the sit-to-stand task. Ten healthy females (20.2±3.0 years and 10 females with patellofemoral pain syndrome (PFPS (21.3±3.4 years participated in this study. The subjects

  11. BECOMING A TOUR GUIDE: ANALYZING THE MOTIVATIONS

    Directory of Open Access Journals (Sweden)

    Monika PRAKASH

    2010-06-01

    Full Text Available Guides play a vital role in this process bringing satisfaction to tourists visiting a country or region/state. The opportunity of direct interaction with the tourists makes them all the more responsible for projecting the correct image of the country/region, giving factually correct information about the destination, ensuring the safety and well being of the tourists as well as pleasing and satisfying the stay for them during their visits. Over last few years there has been a greater interest in tour guide profession especially in the northern region of India.The purpose of this study is to identify the motivations that led to choosing tour guiding as a profession and career. There appears to be a significant difference in such motivation in different regions of the country. A comparison in motivations in two regions (north vs. east was made. Based on primary data collection paper attempts to discuss what has motivated the youth to take up tour guiding profession- whether such motivation is positive of negative. In either case policy makers may decide what type of support programs need to be introduced by the state and other agencies like educational, rearing and counselling, financial support, social security, or any other type of interventions.

  12. Analyzing the environmental impacts of laptop enclosures ...

    Science.gov (United States)

    The market growth of consumer electronics makes it essential for industries and policy-makers to work together to develop sustainable products. The objective of this study is to better understand how to promote environmentally sustainable consumer electronics by examining the use of various materials in laptop enclosures (excluding mounting hardware, internal components, and insulation) using screening-level life cycle assessment. The baseline material, is a fossil plastic blend of polycarbonate-acrylonitrile butadiene styrene. Alternative materials include polylactic acid, bamboo, aluminum, and various combinations of these materials known to be currently used or being considered for use in laptops. The flame retardants considered in this study are bisphenol A bis(diphenyl phosphate), triphenyl phosphate, 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide, and borax-boric acid-phosphorous acid. The Tool for the Reduction and Assessment of Chemical and other environmental Impacts v2.1 was used for the assessment of impacts related to climate change, human and ecological health, and resource use. The assessment demonstrates that plastics, relative to the other materials, are currently some of the better performing materials in terms of having the lowest potential environmental impact for a greater number of impact categories based on product life cycle models developed in this study. For fossil plastics, the material performance increases with increasing post-con

  13. EU Industrial Policy

    DEFF Research Database (Denmark)

    Pellegrin, Julie; Giorgetti, Maria Letizia; Jensen, Camilla

    Following disregard in the 1980s, industrial policy has recently attracted policy attention at EU level. The objective of this study provided by Policy Department A at the request of the ITRE Committee, is to establish the state of the art of a coordinated and integrated EU industrial policy....... It assesses current initiatives, policies and arrangements and proposes an overview of stakeholders' positions at EU and national levels in order to feed into the debate on how to improve competitiveness and growth in Europe....

  14. EUROPEAN MARITIME TRANSPORT POLICY

    Directory of Open Access Journals (Sweden)

    Jerzy Kujawa

    2014-03-01

    Full Text Available The article describes the common EU policy on maritime transport, which comprises almost 80% of the volume of external trade of the Union and about 40% of internal transport needs. The first part of the paper presents the origins of the common maritime transport policy and the difficulties encountered during its initial formation. Subsequently, the evolution of the concepts of the policy and its current shape is discussed. The final, substantial part of the article describes the main aims and directions of the EU maritime transport policy and includes an evaluation of the effects of the policy.

  15. Cyber security policy guidebook

    CERN Document Server

    Bayuk, nifer L; Rohmeyer, l; Sachs, cus; Schmidt, frey; Weiss, eph

    2012-01-01

    This book is a taxonomy and thesaurus of current cybersecurity policy issues, including a thorough description of each issue and a corresponding list of pros and cons with respect to identified stances on each issue. It documents policy alternatives for the sake of clarity with respect to policy alone, and dives into organizational implementation issues. Without using technical jargon, the book emphasizes the importance of critical and analytical thinking when making policy decisions.  It also equips the reader with descriptions of the impact of specific policy ch

  16. Governing EU employment policy

    DEFF Research Database (Denmark)

    Sørensen, Eva; Triantafillou, Peter; Damgaard, Bodil

    2015-01-01

    In the European Union (EU), employment policy is a prerogative of the member states. Therefore the EU's ability to govern in this area depends on its capability to involve national governments and relevant stakeholders in a collaborative effort to formulate and implement shared policy objectives....... Drawing an analytical distinction between cooperation, coordination and collaboration, the article analyses the formulation and implementation of EU employment policies. It concludes that while the formulation of policy objectives and the discussion of national policy approaches do involve elements...... of collaboration, the implementation phase mainly consists in the less demanding forms of cooperation and coordination....

  17. Environmental education policy research

    DEFF Research Database (Denmark)

    Læssøe, Jeppe; Feinstein, Noah Weeth; Blum, Nicole

    2013-01-01

    This essay examines the relationship between research and policy and, more specifically, how researchers might relate to policy work. Given the current international policy focus on climate change, green growth and sustainability in general, it argues for strengthening and widening policy research...... in the areas of Environmental Education (EE), Education for Sustainable Development and Climate Change Education. It especially makes a case for two kinds of research on EE policy: (1) a multi-sited approach to empirical documentation and theory development which explores the relationships between...

  18. Functional and morphological changes in the quadriceps muscle induced by eccentric training after ACL reconstruction Alterações funcionais e morfológicas do quadríceps induzidas pelo treinamento excêntrico após reconstrução do LCA

    Directory of Open Access Journals (Sweden)

    Jamilson S. Brasileiro

    2011-08-01

    Full Text Available OBJECTIVES: The purpose of this study was to investigate the contributions of functional and morphological factors in the recovery of the quadriceps muscle after anterior cruciate ligament (ACL reconstruction. METHODS: Nine subjects (31.3±5.8 years underwent eccentric exercise sessions twice a week for 12 weeks. Quadriceps muscle function was evaluated using an isokinetic dynamometer (isometric and eccentric peak torque and electromyography (RMS. Morphological changes were measured using magnetic resonance imaging. RESULTS: The initial evaluation showed a significant deficit in knee extensor torque in the involved limb and significant muscle atrophy along the length of the quadriceps. EMG activity was lower in all tested situations. Eccentric training significantly increased isokinetic torque (from 199±51 to 240±63, pOBJETIVOS: O propósito deste estudo foi avaliar as contribuições dos fatores funcionais e morfológicos na recuperação da força muscular do quadríceps femoral após reconstrução do Ligamento Cruzado Anterior (LCA. MÉTODOS: Nove indivíduos (31,3±5,8 anos foram treinados por meio de contrações excêntricas máximas, duas vezes por semana, durante 12 semanas. A função do quadríceps foi avaliada pela dinamometria isocinética (pico de torque isométrico e excêntrico e pela eletromiografia (EMG. As alterações morfológicas foram mensuradas por meio de ressonância magnética (RNM. Na avaliação inicial, observou-se significativo déficit no torque extensor do joelho do membro acometido, com hipotrofia muscular de todo o quadríceps e redução na atividade EMG, quando comparado ao membro não-acometido. RESULTADOS: O treinamento excêntrico produziu aumento no torque excêntrico a 30º/s (de 199±51 Nm para 240±63 Nm, p<0,05 e no volume muscular, sendo que maiores hipertrofias ocorreram na região proximal da coxa (de 169±27 para 189±25,8 cm², p<0,01. A atividade EMG do Vasto Medial (VM aumentou nas primeiras

  19. Brain Gain / Circulation Policy and International Student Policy in Korea : In Light of its Migration Policy and Implications for Japan

    OpenAIRE

    Sato, Yuriko

    2015-01-01

    In the knowledge based economy, brain gain has vital importance for many countries. However, the non-English speaking countries, such as Korea and Japan, face a similar disadvantage in attracting talented foreigners. International student policy plays an important role in attracting and fostering future talents in such countries. In this paper, the characteristics of international student policy and brain gain/circulation policy of Korea will be analyzed in light of its emigration history and...

  20. Energy policy and foreign policy in Italy

    International Nuclear Information System (INIS)

    Venanzi, F.

    2001-01-01

    Energy policy in Italy is principally a matter of foreign policy. As a result, extensive programmes for the exploration, development, transport and marketing of oil and natural gas have to be planned and carried out together with the producing countries. In this effort, the country shall need the support of its national energy companies. That is why ENI's controlling interest as well as its mission had better be on Italian hands [it

  1. IRISpy: Analyzing IRIS Data in Python

    Science.gov (United States)

    Ryan, Daniel; Christe, Steven; Mumford, Stuart; Baruah, Ankit; Timothy, Shelbe; Pereira, Tiago; De Pontieu, Bart

    2017-08-01

    IRISpy is a new community-developed open-source software library for analysing IRIS level 2 data. It is written in Python, a free, cross-platform, general-purpose, high-level programming language. A wide array of scientific computing software packages have already been developed in Python, from numerical computation (NumPy, SciPy, etc.), to visualization and plotting (matplotlib), to solar-physics-specific data analysis (SunPy). IRISpy is currently under development as a SunPy-affiliated package which means it depends on the SunPy library, follows similar standards and conventions, and is developed with the support of of the SunPy development team. IRISpy’s has two primary data objects, one for analyzing slit-jaw imager data and another for analyzing spectrograph data. Both objects contain basic slicing, indexing, plotting, and animating functionality to allow users to easily inspect, reduce and analyze the data. As part of this functionality the objects can output SunPy Maps, TimeSeries, Spectra, etc. of relevant data slices for easier inspection and analysis. Work is also ongoing to provide additional data analysis functionality including derivation of systematic measurement errors (e.g. readout noise), exposure time correction, residual wavelength calibration, radiometric calibration, and fine scale pointing corrections. IRISpy’s code base is publicly available through github.com and can be contributed to by anyone. In this poster we demonstrate IRISpy’s functionality and future goals of the project. We also encourage interested users to become involved in further developing IRISpy.

  2. Air sampling unit for breath analyzers

    Science.gov (United States)

    Szabra, Dariusz; Prokopiuk, Artur; Mikołajczyk, Janusz; Ligor, Tomasz; Buszewski, Bogusław; Bielecki, Zbigniew

    2017-11-01

    The paper presents a portable breath sampling unit (BSU) for human breath analyzers. The developed unit can be used to probe air from the upper airway and alveolar for clinical and science studies. The BSU is able to operate as a patient interface device for most types of breath analyzers. Its main task is to separate and to collect the selected phases of the exhaled air. To monitor the so-called I, II, or III phase and to identify the airflow from the upper and lower parts of the human respiratory system, the unit performs measurements of the exhaled CO2 (ECO2) in the concentration range of 0%-20% (0-150 mm Hg). It can work in both on-line and off-line modes according to American Thoracic Society/European Respiratory Society standards. A Tedlar bag with a volume of 5 dm3 is mounted as a BSU sample container. This volume allows us to collect ca. 1-25 selected breath phases. At the user panel, each step of the unit operation is visualized by LED indicators. This helps us to regulate the natural breathing cycle of the patient. There is also an operator's panel to ensure monitoring and configuration setup of the unit parameters. The operation of the breath sampling unit was preliminarily verified using the gas chromatography/mass spectrometry (GC/MS) laboratory setup. At this setup, volatile organic compounds were extracted by solid phase microextraction. The tests were performed by the comparison of GC/MS signals from both exhaled nitric oxide and isoprene analyses for three breath phases. The functionality of the unit was proven because there was an observed increase in the signal level in the case of the III phase (approximately 40%). The described work made it possible to construct a prototype of a very efficient breath sampling unit dedicated to breath sample analyzers.

  3. A chemical analyzer for charged ultrafine particles

    Science.gov (United States)

    Gonser, S. G.; Held, A.

    2013-09-01

    New particle formation is a frequent phenomenon in the atmosphere and of major significance for the Earth's climate and human health. To date the mechanisms leading to the nucleation of particles as well as to aerosol growth are not completely understood. A lack of appropriate measurement equipment for online analysis of the chemical composition of freshly nucleated particles is one major limitation. We have developed a Chemical Analyzer for Charged Ultrafine Particles (CAChUP) capable of analyzing particles with diameters below 30 nm. A bulk of size-separated particles is collected electrostatically on a metal filament, resistively desorbed and subsequently analyzed for its molecular composition in a time of flight mass spectrometer. We report on technical details as well as characterization experiments performed with the CAChUP. Our instrument was tested in the laboratory for its detection performance as well as for its collection and desorption capabilities. The manual application of defined masses of camphene (C10H16) to the desorption filament resulted in a detection limit between 0.5 and 5 ng, and showed a linear response of the mass spectrometer. Flow tube experiments of 25 nm diameter secondary organic aerosol from ozonolysis of alpha-pinene also showed a linear relation between collection time and the mass spectrometer's signal intensity. The resulting mass spectra from the collection experiments are in good agreement with published work on particles generated by the ozonolysis of alpha-pinene. A sensitivity study shows that the current setup of CAChUP is ready for laboratory measurements and for the observation of new particle formation events in the field.

  4. A computer program for analyzing channel geometry

    Science.gov (United States)

    Regan, R.S.; Schaffranek, R.W.

    1985-01-01

    The Channel Geometry Analysis Program (CGAP) provides the capability to process, analyze, and format cross-sectional data for input to flow/transport simulation models or other computational programs. CGAP allows for a variety of cross-sectional data input formats through use of variable format specification. The program accepts data from various computer media and provides for modification of machine-stored parameter values. CGAP has been devised to provide a rapid and efficient means of computing and analyzing the physical properties of an open-channel reach defined by a sequence of cross sections. CGAP 's 16 options provide a wide range of methods by which to analyze and depict a channel reach and its individual cross-sectional properties. The primary function of the program is to compute the area, width, wetted perimeter, and hydraulic radius of cross sections at successive increments of water surface elevation (stage) from data that consist of coordinate pairs of cross-channel distances and land surface or channel bottom elevations. Longitudinal rates-of-change of cross-sectional properties are also computed, as are the mean properties of a channel reach. Output products include tabular lists of cross-sectional area, channel width, wetted perimeter, hydraulic radius, average depth, and cross-sectional symmetry computed as functions of stage; plots of cross sections; plots of cross-sectional area and (or) channel width as functions of stage; tabular lists of cross-sectional area and channel width computed as functions of stage for subdivisions of a cross section; plots of cross sections in isometric projection; and plots of cross-sectional area at a fixed stage as a function of longitudinal distance along an open-channel reach. A Command Procedure Language program and Job Control Language procedure exist to facilitate program execution on the U.S. Geological Survey Prime and Amdahl computer systems respectively. (Lantz-PTT)

  5. Remote Laser Diffraction Particle Size Distribution Analyzer

    Energy Technology Data Exchange (ETDEWEB)

    Batcheller, Thomas Aquinas; Huestis, Gary Michael; Bolton, Steven Michael

    2001-03-01

    In support of a radioactive slurry sampling and physical characterization task, an “off-the-shelf” laser diffraction (classical light scattering) particle size analyzer was utilized for remote particle size distribution (PSD) analysis. Spent nuclear fuel was previously reprocessed at the Idaho Nuclear Technology and Engineering Center (INTEC—formerly recognized as the Idaho Chemical Processing Plant) which is on DOE’s INEEL site. The acidic, radioactive aqueous raffinate streams from these processes were transferred to 300,000 gallon stainless steel storage vessels located in the INTEC Tank Farm area. Due to the transfer piping configuration in these vessels, complete removal of the liquid can not be achieved. Consequently, a “heel” slurry remains at the bottom of an “emptied” vessel. Particle size distribution characterization of the settled solids in this remaining heel slurry, as well as suspended solids in the tank liquid, is the goal of this remote PSD analyzer task. A Horiba Instruments Inc. Model LA-300 PSD analyzer, which has a 0.1 to 600 micron measurement range, was modified for remote application in a “hot cell” (gamma radiation) environment. This technology provides rapid and simple PSD analysis, especially down in the fine and microscopic particle size regime. Particle size analysis of these radioactive slurries down in this smaller range was not previously achievable—making this technology far superior than the traditional methods used. Successful acquisition of this data, in conjunction with other characterization analyses, provides important information that can be used in the myriad of potential radioactive waste management alternatives.

  6. Problematizations in Health Policy

    Directory of Open Access Journals (Sweden)

    Carol Bacchi

    2016-06-01

    Full Text Available This article directs attention to the significance, for health promotion advocates, of reflecting on how “problems” are constituted, or brought into existence, as particular sorts of problems, within policies and policy proposals. To this end, it introduces a poststructural analytic strategy called “What’s the Problem Represented to be?” (WPR approach, and contrasts this perspective to the ways in which “problems” are commonly conceptualized in health policy analyses (e.g., “a problem stream,” “wicked problems”. Such a perspective offers a significant rethinking of the conventional emphasis on agenda setting and policy-making processes in considering the meaning of success or failure in health policy initiatives. The starting point is a close analysis of items that are “successful,” in the sense that they make the political agenda, to see how representations of “problems” within selected policies limit what is talked about as possible or desirable, or as impossible and undesirable. This form of analysis thus enables critical reflections on the substantive content of policy initiatives in health policy. The article takes a step back from policy process theories, frameworks, and models to offer reflections at the level of paradigms. Highlighting potential dangers and limitations in positivism, interpretivism, and critical realism, it uses international, Australian, and South Australian examples in health policy to explore what poststructural policy analysis contributes to understanding the broad political influences shaping contemporary modes of rule.

  7. Analyzing Argumentation In Rich, Natural Contexts

    Directory of Open Access Journals (Sweden)

    Anita Reznitskaya

    2008-02-01

    Full Text Available The paper presents the theoretical and methodological aspects of research on the development of argument- ation in elementary school children. It presents a theoretical framework detailing psychological mechanisms responsible for the acquisition and transfer of argumentative discourse and demonstrates several applications of the framework, described in sufficient detail to guide future empirical investigations of oral, written, individual, or group argumentation performance. Software programs capable of facilitating data analysis are identified and their uses illustrated. The analytic schemes can be used to analyze large amounts of verbal data with reasonable precision and efficiency. The conclusion addresses more generally the challenges for and possibilities of empirical study of the development of argumentation.

  8. Thermo Scientific Ozone Analyzer Instrument Handbook

    Energy Technology Data Exchange (ETDEWEB)

    Springston, S. R. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2016-03-01

    The primary measurement output from the Thermo Scientific Ozone Analyzer is the concentration of the analyte (O3) reported at 1-s resolution in units of ppbv in ambient air. Note that because of internal pneumatic switching limitations the instrument only makes an independent measurement every 4 seconds. Thus, the same concentration number is repeated roughly 4 times at the uniform, monotonic 1-s time base used in the AOS systems. Accompanying instrument outputs include sample temperatures, flows, chamber pressure, lamp intensities and a multiplicity of housekeeping information. There is also a field for operator comments made at any time while data is being collected.

  9. Grid and Data Analyzing and Security

    Directory of Open Access Journals (Sweden)

    Fatemeh SHOKRI

    2012-12-01

    Full Text Available This paper examines the importance of secure structures in the process of analyzing and distributing information with aid of Grid-based technologies. The advent of distributed network has provided many practical opportunities for detecting and recording the time of events, and made efforts to identify the events and solve problems of storing information such as being up-to-date and documented. In this regard, the data distribution systems in a network environment should be accurate. As a consequence, a series of continuous and updated data must be at hand. In this case, Grid is the best answer to use data and resource of organizations by common processing.

  10. Development of a Portable Water Quality Analyzer

    Directory of Open Access Journals (Sweden)

    Germán COMINA

    2010-08-01

    Full Text Available A portable water analyzer based on a voltammetric electronic tongue has been developed. The system uses an electrochemical cell with two working electrodes as sensors, a computer controlled potentiostat, and software based on multivariate data analysis for pattern recognition. The system is suitable to differentiate laboratory made and real in-situ river water samples contaminated with different amounts of Escherichia coli. This bacteria is not only one of the main indicators for water quality, but also a main concern for public health, affecting especially people living in high-burden, resource-limiting settings.

  11. Light-weight analyzer for odor recognition

    Energy Technology Data Exchange (ETDEWEB)

    Vass, Arpad A; Wise, Marcus B

    2014-05-20

    The invention provides a light weight analyzer, e.g., detector, capable of locating clandestine graves. The detector utilizes the very specific and unique chemicals identified in the database of human decompositional odor. This detector, based on specific chemical compounds found relevant to human decomposition, is the next step forward in clandestine grave detection and will take the guess-work out of current methods using canines and ground-penetrating radar, which have historically been unreliable. The detector is self contained, portable and built for field use. Both visual and auditory cues are provided to the operator.

  12. Nonlinear single-spin spectrum analyzer.

    Science.gov (United States)

    Kotler, Shlomi; Akerman, Nitzan; Glickman, Yinnon; Ozeri, Roee

    2013-03-15

    Qubits have been used as linear spectrum analyzers of their environments. Here we solve the problem of nonlinear spectral analysis, required for discrete noise induced by a strongly coupled environment. Our nonperturbative analytical model shows a nonlinear signal dependence on noise power, resulting in a spectral resolution beyond the Fourier limit as well as frequency mixing. We develop a noise characterization scheme adapted to this nonlinearity. We then apply it using a single trapped ion as a sensitive probe of strong, non-Gaussian, discrete magnetic field noise. Finally, we experimentally compared the performance of equidistant vs Uhrig modulation schemes for spectral analysis.

  13. Policies for Renewable Heat

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2012-07-01

    This paper builds on IEA publications, Deploying Renewables, Principles for Effective Policies and Deploying Renewables, Best and Future Policy Practice, that discuss the 'integrated policy approach,' whereby renewable energy technologies require different support policies at different stages of their maturity pathways. The paper discusses how the integrated policy approach applies to renewable heat. It attempts to provide guidance for policy-makers on renewable heat throughout the different phases of the policy lifecycle, allowing for the specific challenges of renewable heat and needs of the many stakeholders involved. Stimulating a market for heat involves challenges that are different and, often, more difficult to overcome than in the electricity and transport sectors.

  14. Policy and Practice

    DEFF Research Database (Denmark)

    Boje, Thomas P.; Ejrnæs, Anders

    2012-01-01

    regimes in Europe – covering the 26 countries. A typology based on a cluster analysis of macro indicators of family policy – coverage of childcare, effective parental leave and spending on family policies. The cluster analysis is based on data from OECD family data base. Then follows an analysis......Purpose – The purpose of this paper is to develop a typology of different family policy systems in Europe and evaluate their impact on the employment strategy of mothers with care responsibilities for dependent children. Design/methodology/approach – The paper outlines a typology of family policy...... of the impact of the different family policy regimes on mothers' employment strategies when they return into gainful employment, based on data from the European Social Survey, 2008. Findings – The authors have identified four different family policy models: extensive family policy, long parental leave, family...

  15. Implementing public employment policy

    DEFF Research Database (Denmark)

    Larsen, Flemming; Bredgaard, Thomas

    . But there is an interesting question to investigate here: whether and if so how, NPM-inspired reforms are related to changes in employment policy towards a work-first approach? Are changes in public management systems created as deliberate policy changes, or do they bring about more indirect and unintended policy changes......Like most other areas within welfare policy, the employment and social policy areas are undergoing far-reaching changes in many countries. Partly in the shape of new forms of governance inspired by New Public Management (NPM), partly through new policies oriented towards activation and stronger...... disciplining of the unemployed (work first) (cf.Bredgaard & Larsen, 2005; Sol & Westerweld, 2005). It is, however, remarkable that in the research field there seems to be a division of labour so that changes in public administration and changes in the substance of employment policies are dealt with separately...

  16. Analyzing delay causes in Egyptian construction projects.

    Science.gov (United States)

    Marzouk, Mohamed M; El-Rasas, Tarek I

    2014-01-01

    Construction delays are common problems in civil engineering projects in Egypt. These problems occur frequently during project life-time leading to disputes and litigation. Therefore, it is essential to study and analyze causes of construction delays. This research presents a list of construction delay causes retrieved from literature. The feedback of construction experts was obtained through interviews. Subsequently, a questionnaire survey was prepared. The questionnaire survey was distributed to thirty-three construction experts who represent owners, consultants, and contractor's organizations. Frequency Index, Severity Index, and Importance Index are calculated and according to the highest values of them the top ten delay causes of construction projects in Egypt are determined. A case study is analyzed and compared to the most important delay causes in the research. Statistical analysis is carried out using analysis of variance ANOVA method to test delay causes, obtained from the survey. The test results reveal good correlation between groups while there is significant difference between them for some delay causes and finally roadmap for prioritizing delay causes groups is presented.

  17. Plutonium solution analyzer. Revised February 1995

    International Nuclear Information System (INIS)

    Burns, D.A.

    1995-02-01

    A fully automated analyzer has been developed for plutonium solutions. It was assembled from several commercially available modules, is based upon segmented flow analysis, and exhibits precision about an order of magnitude better than commercial units (0.5%--0.05% RSD). The system was designed to accept unmeasured, untreated liquid samples in the concentration range 40--240 g/l: and produce a report with sample identification, sample concentrations, and an abundance of statistics. Optional hydraulics can accommodate samples in the concentration range 0.4--4.0 g/y. Operating at a typical rate of 30 to 40 samples per hour, it consumes only 0.074 ml of each sample and standard, and generates waste at the rate of about 1.5 ml per minute. No radioactive material passes through its multichannel peristaltic pump (which remains outside the glovebox, uncontaminated) but rather is handled by a 6-port, 2-position chromatography-type loop valve. An accompanying computer is programmed in QuickBASIC 4.5 to provide both instrument control and data reduction. The program is truly user-friendly and communication between operator and instrument is via computer screen displays and keyboard. Two important issues which have been addressed are waste minimization and operator safety (the analyzer can run in the absence of an operator, once its autosampler has been loaded)

  18. Mango: combining and analyzing heterogeneous biological networks.

    Science.gov (United States)

    Chang, Jennifer; Cho, Hyejin; Chou, Hui-Hsien

    2016-01-01

    Heterogeneous biological data such as sequence matches, gene expression correlations, protein-protein interactions, and biochemical pathways can be merged and analyzed via graphs, or networks. Existing software for network analysis has limited scalability to large data sets or is only accessible to software developers as libraries. In addition, the polymorphic nature of the data sets requires a more standardized method for integration and exploration. Mango facilitates large network analyses with its Graph Exploration Language, automatic graph attribute handling, and real-time 3-dimensional visualization. On a personal computer Mango can load, merge, and analyze networks with millions of links and can connect to online databases to fetch and merge biological pathways. Mango is written in C++ and runs on Mac OS, Windows, and Linux. The stand-alone distributions, including the Graph Exploration Language integrated development environment, are freely available for download from http://www.complex.iastate.edu/download/Mango. The Mango User Guide listing all features can be found at http://www.gitbook.com/book/j23414/mango-user-guide.

  19. Analyzing block placement errors in SADP patterning

    Science.gov (United States)

    Kobayashi, Shinji; Okada, Soichiro; Shimura, Satoru; Nafus, Kathleen; Fonseca, Carlos; Demand, Marc; Biesemans, Serge; Versluijs, Janko; Ercken, Monique; Foubert, Philippe; Miyazaki, Shinobu

    2016-03-01

    We discuss edge placement errors (EPE) for multi-patterning of Mx critical layers using ArF lithography. Specific focus is placed on the block formation part of the process. While plenty of literature characterization data exist on spacer formation, only limited published data is available on block processes. We analyze the accuracy of placing blocks relative to narrow spacers. Many publications calculate EPE assuming Gaussian distributions for key process variations contributing to EPE. For practical reasons, each contributor is measured on dedicated test structures. In this work, we complement such analysis and directly measure the EPE in product. We perform high density sampling of blocks using CDSEM images and analyze all feature edges of interest. We find that block placement errors can be very different depending on their local design context. Specifically we report on 2 block populations (further called block A and B) which have a 4x different standard deviation. We attribute this to differences in local topography (spacer shape) and interaction with the plasma-etch process design. Block A (on top of the `core space' S1) has excellent EPE uniformity of ~1 nm while block B (on top of `gap space' S2) has degraded EPE control of ~4 nm. Finally, we suggest that the SOC etch process is at the origin on positioning blocks accurately on slim spacers, helping the manufacturability of spacer-based patterning techniques, and helping its extension toward the 5nm node.

  20. Analyzing endocrine system conservation and evolution.

    Science.gov (United States)

    Bonett, Ronald M

    2016-08-01

    Analyzing variation in rates of evolution can provide important insights into the factors that constrain trait evolution, as well as those that promote diversification. Metazoan endocrine systems exhibit apparent variation in evolutionary rates of their constituent components at multiple levels, yet relatively few studies have quantified these patterns and analyzed them in a phylogenetic context. This may be in part due to historical and current data limitations for many endocrine components and taxonomic groups. However, recent technological advancements such as high-throughput sequencing provide the opportunity to collect large-scale comparative data sets for even non-model species. Such ventures will produce a fertile data landscape for evolutionary analyses of nucleic acid and amino acid based endocrine components. Here I summarize evolutionary rate analyses that can be applied to categorical and continuous endocrine traits, and also those for nucleic acid and protein-based components. I emphasize analyses that could be used to test whether other variables (e.g., ecology, ontogenetic timing of expression, etc.) are related to patterns of rate variation and endocrine component diversification. The application of phylogenetic-based rate analyses to comparative endocrine data will greatly enhance our understanding of the factors that have shaped endocrine system evolution. Copyright © 2016 Elsevier Inc. All rights reserved.

  1. Analyzing rare diseases terms in biomedical terminologies

    Directory of Open Access Journals (Sweden)

    Erika Pasceri

    2012-03-01

    Full Text Available Rare disease patients too often face common problems, including the lack of access to correct diagnosis, lack of quality information on the disease, lack of scientific knowledge of the disease, inequities and difficulties in access to treatment and care. These things could be changed by implementing a comprehensive approach to rare diseases, increasing international cooperation in scientific research, by gaining and sharing scientific knowledge about and by developing tools for extracting and sharing knowledge. A significant aspect to analyze is the organization of knowledge in the biomedical field for the proper management and recovery of health information. For these purposes, the sources needed have been acquired from the Office of Rare Diseases Research, the National Organization of Rare Disorders and Orphanet, organizations that provide information to patients and physicians and facilitate the exchange of information among different actors involved in this field. The present paper shows the representation of rare diseases terms in biomedical terminologies such as MeSH, ICD-10, SNOMED CT and OMIM, leveraging the fact that these terminologies are integrated in the UMLS. At the first level, it was analyzed the overlap among sources and at a second level, the presence of rare diseases terms in target sources included in UMLS, working at the term and concept level. We found that MeSH has the best representation of rare diseases terms.

  2. CALIBRATION OF ONLINE ANALYZERS USING NEURAL NETWORKS

    Energy Technology Data Exchange (ETDEWEB)

    Rajive Ganguli; Daniel E. Walsh; Shaohai Yu

    2003-12-05

    Neural networks were used to calibrate an online ash analyzer at the Usibelli Coal Mine, Healy, Alaska, by relating the Americium and Cesium counts to the ash content. A total of 104 samples were collected from the mine, with 47 being from screened coal, and the rest being from unscreened coal. Each sample corresponded to 20 seconds of coal on the running conveyor belt. Neural network modeling used the quick stop training procedure. Therefore, the samples were split into training, calibration and prediction subsets. Special techniques, using genetic algorithms, were developed to representatively split the sample into the three subsets. Two separate approaches were tried. In one approach, the screened and unscreened coal was modeled separately. In another, a single model was developed for the entire dataset. No advantage was seen from modeling the two subsets separately. The neural network method performed very well on average but not individually, i.e. though each prediction was unreliable, the average of a few predictions was close to the true average. Thus, the method demonstrated that the analyzers were accurate at 2-3 minutes intervals (average of 6-9 samples), but not at 20 seconds (each prediction).

  3. Analyzing Virtual Physics Simulations with Tracker

    Science.gov (United States)

    Claessens, Tom

    2017-12-01

    In the physics teaching community, Tracker is well known as a user-friendly open source video analysis software, authored by Douglas Brown. With this tool, the user can trace markers indicated on a video or on stroboscopic photos and perform kinematic analyses. Tracker also includes a data modeling tool that allows one to fit some theoretical equations of motion onto experimentally obtained data. In the field of particle mechanics, Tracker has been effectively used for learning and teaching about projectile motion, "toss up" and free-fall vertical motion, and to explain the principle of mechanical energy conservation. Also, Tracker has been successfully used in rigid body mechanics to interpret the results of experiments with rolling/slipping cylinders and moving rods. In this work, I propose an original method in which Tracker is used to analyze virtual computer simulations created with a physics-based motion solver, instead of analyzing video recording or stroboscopic photos. This could be an interesting approach to study kinematics and dynamics problems in physics education, in particular when there is no or limited access to physical labs. I demonstrate the working method with a typical (but quite challenging) problem in classical mechanics: a slipping/rolling cylinder on a rough surface.

  4. Calibration of the portable wear metal analyzer

    Science.gov (United States)

    Quinn, Michael J.

    1987-12-01

    The Portable Wear Metal Analyzer (PWMA), a graphite furnace atomic absorption (AA) spectrometer, developed under a contract for this laboratory, was evaluated using powdered metal particles suspended in oil. The PWMA is a microprocessor controlled automatic sequential multielement AA spectrometer designed to support the deployed aircraft requirement for spectrometric oil analysis. The PWMA will analyze for nine elements (Ni, Fe, Cu, Cr, Ag, Mg, Si, Ti, Al) at a rate of 4 min per sample. The graphite tube and modified sample introduction system increase the detection of particles in oil when compared to the currently used techniques of flame AA or spark atomic emission (AE) spectroscopy. The PWMA shows good-to-excellent response for particles in sizes of 0 to 5 and 5 to 10 micrometers and fair response to particles of 10 to 20 and 20 to 30 micrometers. All trends in statistical variations are easily explained by system considerations. Correction factors to the calibration curves are necessary to correlate the analytical capability of the PWMA to the performance of existing spectrometric oil analysis (SOA) instruments.

  5. Solar Probe ANalyzer for Ions - Laboratory Performance

    Science.gov (United States)

    Livi, R.; Larson, D. E.; Kasper, J. C.; Korreck, K. E.; Whittlesey, P. L.

    2017-12-01

    The Parker Solar Probe (PSP) mission is a heliospheric satellite that will orbit the Sun closer than any prior mission to date with a perihelion of 35 solar radii (RS) and an aphelion of 10 RS. PSP includes the Solar Wind Electrons Alphas and Protons (SWEAP) instrument suite, which in turn consists of four instruments: the Solar Probe Cup (SPC) and three Solar Probe ANalyzers (SPAN) for ions and electrons. Together, this suite will take local measurements of particles and electromagnetic fields within the Sun's corona. SPAN-Ai has completed flight calibration and spacecraft integration and is set to be launched in July of 2018. The main mode of operation consists of an electrostatic analyzer (ESA) at its aperture followed by a Time-of-Flight section to measure the energy and mass per charge (m/q) of the ambient ions. SPAN-Ai's main objective is to measure solar wind ions within an energy range of 5 eV - 20 keV, a mass/q between 1-60 [amu/q] and a field of view of 2400x1200. Here we will show flight calibration results and performance.

  6. Optoacoustic 13C-breath test analyzer

    Science.gov (United States)

    Harde, Hermann; Helmrich, Günther; Wolff, Marcus

    2010-02-01

    The composition and concentration of exhaled volatile gases reflects the physical ability of a patient. Therefore, a breath analysis allows to recognize an infectious disease in an organ or even to identify a tumor. One of the most prominent breath tests is the 13C-urea-breath test, applied to ascertain the presence of the bacterium helicobacter pylori in the stomach wall as an indication of a gastric ulcer. In this contribution we present a new optical analyzer that employs a compact and simple set-up based on photoacoustic spectroscopy. It consists of two identical photoacoustic cells containing two breath samples, one taken before and one after capturing an isotope-marked substrate, where the most common isotope 12C is replaced to a large extent by 13C. The analyzer measures simultaneously the relative CO2 isotopologue concentrations in both samples by exciting the molecules on specially selected absorption lines with a semiconductor laser operating at a wavelength of 2.744 μm. For a reliable diagnosis changes of the 13CO2 concentration of 1% in the exhaled breath have to be detected at a concentration level of this isotope in the breath of about 500 ppm.

  7. Analyzing surface coatings in situ: High-temperature surface film analyzer developed

    International Nuclear Information System (INIS)

    Anon.

    1991-01-01

    Scientists at Argonne National Laboratory (ANL) have devised a new instrument that can analyze surface coatings under operating conditions. The High-Temperature Surface Film Analyzer is the first such instrument to analyze the molecular composition and structure of surface coatings on metals and solids under conditions of high temperature and pressure in liquid environments. Corrosion layers, oxide coatings, polymers or paint films, or adsorbed molecules are examples of conditions that can be analyzed using this instrument. Film thicknesses may vary from a few molecular layers to several microns or thicker. The instrument was originally developed to study metal corrosion in aqueous solutions similar to the cooling water systems of light-water nuclear reactors. The instrument may have use for the nuclear power industry where coolant pipes degrade due to stress corrosion cracking, which often leads to plant shutdown. Key determinants in the occurrence of stress corrosion cracking are the properties and composition of corrosion scales that form inside pipes. The High-Temperature Surface Analyzer can analyze these coatings under laboratory conditions that simulate the same hostile environment of high temperature, pressure, and solution that exist during plant operations. The ability to analyze these scales in hostile liquid environments is unique to the instrument. Other applications include analyzing paint composition, corrosion of materials in geothermal power systems, integrity of canisters for radioactive waste storage, corrosion inhibitor films on piping and drilling systems, and surface scales on condenser tubes in industrial hot water heat exchangers. The device is not patented

  8. Corruption, democracy, and environmental policy. An empirical contribution to the debate

    NARCIS (Netherlands)

    Pellegrini, L.; Gerlagh, R.

    2006-01-01

    Theoretical and empirical studies have shown that democracy and corruption influence environmental policies. In this article, the authors empirically analyze the relative importance of these determinants of environmental policy. When these variables are jointly included as explanatory variables in a

  9. Solving the Policy Implementation Problem: The Case of Arizona Charter Schools.

    Science.gov (United States)

    Garn, Gregg A.

    1999-01-01

    Analyzes how Arizona charter school policymakers succeeded in preserving the legislative intentions of the state's charter school program. Identifies four key features of policy implementation that created the charter school policy: communication, financial resources, implementor attitudes, and bureaucratic structure. (SLD)

  10. Automated Root Tracking with "Root System Analyzer"

    Science.gov (United States)

    Schnepf, Andrea; Jin, Meina; Ockert, Charlotte; Bol, Roland; Leitner, Daniel

    2015-04-01

    Crucial factors for plant development are water and nutrient availability in soils. Thus, root architecture is a main aspect of plant productivity and needs to be accurately considered when describing root processes. Images of root architecture contain a huge amount of information, and image analysis helps to recover parameters describing certain root architectural and morphological traits. The majority of imaging systems for root systems are designed for two-dimensional images, such as RootReader2, GiA Roots, SmartRoot, EZ-Rhizo, and Growscreen, but most of them are semi-automated and involve mouse-clicks in each root by the user. "Root System Analyzer" is a new, fully automated approach for recovering root architectural parameters from two-dimensional images of root systems. Individual roots can still be corrected manually in a user interface if required. The algorithm starts with a sequence of segmented two-dimensional images showing the dynamic development of a root system. For each image, morphological operators are used for skeletonization. Based on this, a graph representation of the root system is created. A dynamic root architecture model helps to determine which edges of the graph belong to an individual root. The algorithm elongates each root at the root tip and simulates growth confined within the already existing graph representation. The increment of root elongation is calculated assuming constant growth. For each root, the algorithm finds all possible paths and elongates the root in the direction of the optimal path. In this way, each edge of the graph is assigned to one or more coherent roots. Image sequences of root systems are handled in such a way that the previous image is used as a starting point for the current image. The algorithm is implemented in a set of Matlab m-files. Output of Root System Analyzer is a data structure that includes for each root an identification number, the branching order, the time of emergence, the parent

  11. Positioning women's and children's health in African union policy-making: a policy analysis

    Directory of Open Access Journals (Sweden)

    Toure Kadidiatou

    2012-02-01

    Full Text Available Abstract Background With limited time to achieve the Millennium Development Goals, progress towards improving women's and children's health needs to be accelerated. With Africa accounting for over half of the world's maternal and child deaths, the African Union (AU has a critical role in prioritizing related policies and catalysing required investments and action. In this paper, the authors assess the evolution of African Union policies related to women's and children's health, and analyze how these policies are prioritized and framed. Methods The main method used in this policy analysis was a document review of all African Union policies developed from 1963 to 2010, focusing specifically on policies that explicitly mention health. The findings from this document review were discussed with key actors to identify policy implications. Results With over 220 policies in total, peace and security is the most common AU policy topic. Social affairs and other development issues became more prominent in the 1990s. The number of policies that mentioned health rose steadily over the years (with 1 policy mentioning health in 1963 to 7 in 2010. This change was catalysed by factors such as: a favourable shift in AU priorities and systems towards development issues, spurred by the transition from the Organization of African Unity to the African Union; the mandate of the African Commission on Human and People's Rights; health-related advocacy initiatives, such as the Campaign for the Accelerated Reduction of Maternal Mortality in Africa (CARMMA; action and accountability requirements arising from international human rights treaties, the Millennium Development Goals (MDGs, and new health-funding mechanisms, such as the Global Fund to Fight AIDS, Tuberculosis and Malaria. Prioritization of women's and children's health issues in AU policies has been framed primarily by human rights, advocacy and accountability considerations, more by economic and health frames

  12. Analyzer of neutron flux in real time

    International Nuclear Information System (INIS)

    Rojas S, A.S.; Carrillo M, R.A.; Balderas, E.G.

    1999-01-01

    With base in the study of the real signals of neutron flux of instability events occurred in the Laguna Verde nuclear power plant where the nucleus oscillation phenomena of the reactor are in the 0 to 2.5 Hz range, it has been seen the possibility about the development a surveillance and diagnostic equipment capable to analyze in real time the behavior of nucleus in this frequencies range. An important method for surveillance the stability of the reactor nucleus is the use of the Power spectral density which allows to determine the frequencies and amplitudes contained in the signals. It is used an instrument carried out by LabVIEW graphic programming with a data acquisition card of 16 channels which works at Windows 95/98 environment. (Author)

  13. Analyzing the Control Structure of PEPA

    DEFF Research Database (Denmark)

    Yang, Fan; Nielson, Hanne Riis

    expressed in PEPA. The analysis technique we adopted is Data Flow Analysis. We begin the analysis by defining an appropriate transfer function, then with the classical worklist algorithm we construct a finite automaton that captures all possible interactions among processes. By annotating labels and layers...... to PEPA programs, the approximating result is very precise. Based on the analysis, we also develop algorithms for validating the deadlock property of PEPA programs. The techniques have been implemented in a tool which is able to analyze processes with a control structure that more than one thousand states.......The Performance Evaluation Process Algebra, PEPA, is introduced by Jane Hillston as a stochastic process algebra for modelling distributed systems and especially suitable for performance evaluation. We present a static analysis that very precisely approximates the control structure of processes...

  14. Buccal microbiology analyzed by infrared spectroscopy

    Science.gov (United States)

    de Abreu, Geraldo Magno Alves; da Silva, Gislene Rodrigues; Khouri, Sônia; Favero, Priscila Pereira; Raniero, Leandro; Martin, Airton Abrahão

    2012-01-01

    Rapid microbiological identification and characterization are very important in dentistry and medicine. In addition to dental diseases, pathogens are directly linked to cases of endocarditis, premature delivery, low birth weight, and loss of organ transplants. Fourier Transform Infrared Spectroscopy (FTIR) was used to analyze oral pathogens Aggregatibacter actinomycetemcomitans ATCC 29523, Aggregatibacter actinomycetemcomitans-JP2, and Aggregatibacter actinomycetemcomitans which was clinically isolated from the human blood-CI. Significant spectra differences were found among each organism allowing the identification and characterization of each bacterial species. Vibrational modes in the regions of 3500-2800 cm-1, the 1484-1420 cm-1, and 1000-750 cm-1 were used in this differentiation. The identification and classification of each strain were performed by cluster analysis achieving 100% separation of strains. This study demonstrated that FTIR can be used to decrease the identification time, compared to the traditional methods, of fastidious buccal microorganisms associated with the etiology of the manifestation of periodontitis.

  15. Nuclear Plant Analyzer: Installation manual. Volume 1

    International Nuclear Information System (INIS)

    Snider, D.M.; Wagner, K.L.; Grush, W.H.; Jones, K.R.

    1995-01-01

    This report contains the installation instructions for the Nuclear Plant Analyzer (NPA) System. The NPA System consists of the Computer Visual System (CVS) program, the NPA libraries, the associated utility programs. The NPA was developed at the Idaho National Engineering Laboratory under the sponsorship of the US Nuclear Regulatory Commission to provide a highly flexible graphical user interface for displaying the results of these analysis codes. The NPA also provides the user with a convenient means of interactively controlling the host program through user-defined pop-up menus. The NPA was designed to serve primarily as an analysis tool. After a brief introduction to the Computer Visual System and the NPA, an analyst can quickly create a simple picture or set of pictures to aide in the study of a particular phenomenon. These pictures can range from simple collections of square boxes and straight lines to complex representations of emergency response information displays

  16. Using wavelet features for analyzing gamma lines

    International Nuclear Information System (INIS)

    Medhat, M.E.; Abdel-hafiez, A.; Hassan, M.F.; Ali, M.A.; Uzhinskii, V.V.

    2004-01-01

    Data processing methods for analyzing gamma ray spectra with symmetric bell-shaped peaks form are considered. In many cases the peak form is symmetrical bell shaped in particular a Gaussian case is the most often used due to many physical reasons. The problem is how to evaluate parameters of such peaks, i.e. their positions, amplitudes and also their half-widths, that is for a single peak and overlapped peaks. Through wavelet features by using Marr wavelet (Mexican Hat) as a correlation method, it could be to estimate the optimal wavelet parameters and to locate peaks in the spectrum. The performance of the proposed method and others shows a better quality of wavelet transform method

  17. Coke from small-diameter tubes analyzed

    International Nuclear Information System (INIS)

    Albright, L.F.

    1988-01-01

    The mechanism for coke deposit formation and the nature of the coke itself can vary with the design of the ethylene furnace tube bank. In this article, coke deposits from furnaces with small-diameter pyrolysis tubes are examined. The samples were taken from four furnaces of identical design (Plant B). As in both the first and second installments of the series, the coke deposits were examined using a scanning electron microscope (SEM) and an energy dispersive X-ray analyzer (EDAX). The deposits from the small-diameter tubes are compared with the coke deposits from the furnace discussed in earlier articles. Analysis of the coke in both sets of samples are then used to offer recommendations for improved decoking procedures, operating procedures, better feed selection, and better selection of the metallurgy used in furnace tubes, to extend the operating time of the furnace tubes by reducing the amount and type of coke build up

  18. Analyzing Options for Airborne Emergency Wireless Communications

    Energy Technology Data Exchange (ETDEWEB)

    Michael Schmitt; Juan Deaton; Curt Papke; Shane Cherry

    2008-03-01

    In the event of large-scale natural or manmade catastrophic events, access to reliable and enduring commercial communication systems is critical. Hurricane Katrina provided a recent example of the need to ensure communications during a national emergency. To ensure that communication demands are met during these critical times, Idaho National Laboratory (INL) under the guidance of United States Strategic Command has studied infrastructure issues, concerns, and vulnerabilities associated with an airborne wireless communications capability. Such a capability could provide emergency wireless communications until public/commercial nodes can be systematically restored. This report focuses on the airborne cellular restoration concept; analyzing basic infrastructure requirements; identifying related infrastructure issues, concerns, and vulnerabilities and offers recommended solutions.

  19. Sensors and Automated Analyzers for Radionuclides

    International Nuclear Information System (INIS)

    Grate, Jay W.; Egorov, Oleg B.

    2003-01-01

    The production of nuclear weapons materials has generated large quantities of nuclear waste and significant environmental contamination. We have developed new, rapid, automated methods for determination of radionuclides using sequential injection methodologies to automate extraction chromatographic separations, with on-line flow-through scintillation counting for real time detection. This work has progressed in two main areas: radionuclide sensors for water monitoring and automated radiochemical analyzers for monitoring nuclear waste processing operations. Radionuclide sensors have been developed that collect and concentrate radionuclides in preconcentrating minicolumns with dual functionality: chemical selectivity for radionuclide capture and scintillation for signal output. These sensors can detect pertechnetate to below regulatory levels and have been engineered into a prototype for field testing. A fully automated process monitor has been developed for total technetium in nuclear waste streams. This instrument performs sample acidification, speciation adjustment, separation and detection in fifteen minutes or less

  20. Analyzing, Modelling, and Designing Software Ecosystems

    DEFF Research Database (Denmark)

    Manikas, Konstantinos

    the development, implementation, and use of telemedicine services. We initially expand the theory of software ecosystems by contributing to the definition and understanding of software ecosystems, providing means of analyzing existing and designing new ecosystems, and defining and measuring the qualities...... of software ecosystems. We use these contributions to design a software ecosystem in the telemedicine services of Denmark with (i) a common platform that supports and promotes development from different actors, (ii) high software interaction, (iii) strong social network of actors, (iv) robust business....... This thesis documents the groundwork towards addressing the challenges faced by telemedical technologies today and establishing telemedicine as a means of patient diagnosis and treatment. Furthermore, it serves as an empirical example of designing a software ecosystem....

  1. Analyzing Strategic Business Rules through Simulation Modeling

    Science.gov (United States)

    Orta, Elena; Ruiz, Mercedes; Toro, Miguel

    Service Oriented Architecture (SOA) holds promise for business agility since it allows business process to change to meet new customer demands or market needs without causing a cascade effect of changes in the underlying IT systems. Business rules are the instrument chosen to help business and IT to collaborate. In this paper, we propose the utilization of simulation models to model and simulate strategic business rules that are then disaggregated at different levels of an SOA architecture. Our proposal is aimed to help find a good configuration for strategic business objectives and IT parameters. The paper includes a case study where a simulation model is built to help business decision-making in a context where finding a good configuration for different business parameters and performance is too complex to analyze by trial and error.

  2. Method and apparatus for analyzing ionizable materials

    International Nuclear Information System (INIS)

    Ehrlich, B.J.; Hall, R.C.; Thiede, P.W.

    1979-01-01

    An apparatus and method are described for analyzing a solution of ionizable compounds in a liquid. The solution is irradiated with electromagnetic radiation to ionize the compounds and the electrical conductivity of the solution is measured. The radiation may be X-rays, ultra-violet, infra-red or microwaves. The solution may be split into two streams, only one of which is irradiated, the other being used as a reference by comparing conductivities of the two streams. The liquid must be nonionizable and is preferably a polar solvent. The invention provides an analysis technique useful in liquid chromatography and in gas chromatography after dissolving the eluted gases in a suitable solvent. Electrical conductivity measurements performed on the irradiated eluent provide a quantitative indication of the ionizable materials existing within the eluent stream and a qualitative indication of the purity of the eluent stream. (author)

  3. Analyzing, Modelling, and Designing Software Ecosystems

    DEFF Research Database (Denmark)

    Manikas, Konstantinos

    as the software development and distribution by a set of actors dependent on each other and the ecosystem. We commence on the hypothesis that the establishment of a software ecosystem on the telemedicine services of Denmark would address these issues and investigate how a software ecosystem can foster...... the development, implementation, and use of telemedicine services. We initially expand the theory of software ecosystems by contributing to the definition and understanding of software ecosystems, providing means of analyzing existing and designing new ecosystems, and defining and measuring the qualities...... of software ecosystems. We use these contributions to design a software ecosystem in the telemedicine services of Denmark with (i) a common platform that supports and promotes development from different actors, (ii) high software interaction, (iii) strong social network of actors, (iv) robust business...

  4. Stackable differential mobility analyzer for aerosol measurement

    Energy Technology Data Exchange (ETDEWEB)

    Cheng, Meng-Dawn [Oak Ridge, TN; Chen, Da-Ren [Creve Coeur, MO

    2007-05-08

    A multi-stage differential mobility analyzer (MDMA) for aerosol measurements includes a first electrode or grid including at least one inlet or injection slit for receiving an aerosol including charged particles for analysis. A second electrode or grid is spaced apart from the first electrode. The second electrode has at least one sampling outlet disposed at a plurality different distances along its length. A volume between the first and the second electrode or grid between the inlet or injection slit and a distal one of the plurality of sampling outlets forms a classifying region, the first and second electrodes for charging to suitable potentials to create an electric field within the classifying region. At least one inlet or injection slit in the second electrode receives a sheath gas flow into an upstream end of the classifying region, wherein each sampling outlet functions as an independent DMA stage and classifies different size ranges of charged particles based on electric mobility simultaneously.

  5. Analyzing use cases for knowledge acquisition

    Science.gov (United States)

    Kelsey, Robert L.; Webster, Robert B.

    2000-03-01

    The analysis of use cases describing construction of simulation configuration files in a data/information management system can lead to the acquisition of new information and knowledge. In this application, a user creates a use case with an eXtensible Markup Language (XML) description representing a configuration file for simulation of a physical system. INtelligent agents analyze separate versions of the XML descriptions of a user and additionally, make comparisons of the descriptions with examples form a library of use cases. The agents can then make recommendations to a user on how to proceed or if tutoring is necessary. In a proof-of-concept test, new information is acquired and a user learns from the agent-facilitated tutoring.

  6. Spectroscopic methods to analyze drug metabolites.

    Science.gov (United States)

    Yi, Jong-Jae; Park, Kyeongsoon; Kim, Won-Je; Rhee, Jin-Kyu; Son, Woo Sung

    2018-03-09

    Drug metabolites have been monitored with various types of newly developed techniques and/or combination of common analytical methods, which could provide a great deal of information on metabolite profiling. Because it is not easy to analyze whole drug metabolites qualitatively and quantitatively, a single solution of analytical techniques is combined in a multilateral manner to cover the widest range of drug metabolites. Mass-based spectroscopic analysis of drug metabolites has been expanded with the help of other parameter-based methods. The current development of metabolism studies through contemporary pharmaceutical research are reviewed with an overview on conventionally used spectroscopic methods. Several technical approaches for conducting drug metabolic profiling through spectroscopic methods are discussed in depth.

  7. Analyzing petabytes of data with Hadoop

    CERN Multimedia

    CERN. Geneva

    2009-01-01

    Abstract The open source Apache Hadoop project provides a powerful suite of tools for storing and analyzing petabytes of data using commodity hardware. After several years of production use inside of web companies like Yahoo! and Facebook and nearly a year of commercial support and development by Cloudera, the technology is spreading rapidly through other disciplines, from financial services and government to life sciences and high energy physics. The talk will motivate the design of Hadoop and discuss some key implementation details in depth. It will also cover the major subprojects in the Hadoop ecosystem, go over some example applications, highlight best practices for deploying Hadoop in your environment, discuss plans for the future of the technology, and provide pointers to the many resources available for learning more. In addition to providing more information about the Hadoop platform, a major goal of this talk is to begin a dialogue with the ATLAS research team on how the tools commonly used in t...

  8. Orthopedic surgical analyzer for percutaneous vertebroplasty

    Science.gov (United States)

    Tack, Gye Rae; Choi, Hyung Guen; Lim, Do H.; Lee, Sung J.

    2001-05-01

    Since the spine is one of the most complex joint structures in the human body, its surgical treatment requires careful planning and high degree of precision to avoid any unwanted neurological compromises. In addition, comprehensive biomechanical analysis can be very helpful because the spine is subject to a variety of load. In case for the osteoporotic spine in which the structural integrity has been compromised, it brings out the double challenges for a surgeon both clinically and biomechanically. Thus, we have been developing an integrated medical image system that is capable of doing the both. This system is called orthopedic surgical analyzer and it combines the clinical results from image-guided examination and the biomechanical data from finite element analysis. In order to demonstrate its feasibility, this system was applied to percutaneous vertebroplasty. Percutaneous vertebroplasty is a surgical procedure that has been recently introduced for the treatment of compression fracture of the osteoporotic vertebrae. It involves puncturing vertebrae and filling with polymethylmethacrylate (PMMA). Recent studies have shown that the procedure could provide structural reinforcement for the osteoporotic vertebrae while being minimally invasive and safe with immediate pain relief. However, treatment failures due to excessive PMMA volume injection have been reported as one of complications. It is believed that control of PMMA volume is one of the most critical factors that can reduce the incidence of complications. Since the degree of the osteoporosis can influence the porosity of the cancellous bone in the vertebral body, the injection volume can be different from patient to patient. In this study, the optimal volume of PMMA injection for vertebroplasty was predicted based on the image analysis of a given patient. In addition, biomechanical effects due to the changes in PMMA volume and bone mineral density (BMD) level were investigated by constructing clinically

  9. A Study on the Nuclear Technology Policy

    International Nuclear Information System (INIS)

    Kim, H. J.; Lim, C. Y.; Yang, M. H.

    2008-03-01

    The objective of the study was to make policy-proposes for enhancing the effectiveness and efficiency of national nuclear technology development programs. To do this, changes of international nuclear energy policy environment and trends of nuclear technology development was surveyed and analyzed. In the viewpoint of analysis of the changes in the global policy environment surrounding nuclear technology development and development of national nuclear R and D strategy, this study (1) analyzed trends of nuclear technology policies and (2) developed the nuclear energy R and D innovation strategies. To put it in more detail, each subject was further explored as follows; (1) themes to analyze trends of nuclear policies: nuclear Renaissance and forecast for nuclear power plant, International collaboration for advanced nuclear technologies in GIF, INPRO and I-NERI, The present situation and outlook for world uranium market (2) themes to develop of nuclear energy R and D innovation strategies: The mid-term strategy plan of the KAERI, The technological innovation case of the KAERI

  10. A Study on the Nuclear Technology Policy

    Energy Technology Data Exchange (ETDEWEB)

    Kim, H. J.; Lim, C. Y.; Yang, M. H. (and others)

    2008-03-15

    The objective of the study was to make policy-proposes for enhancing the effectiveness and efficiency of national nuclear technology development programs. To do this, changes of international nuclear energy policy environment and trends of nuclear technology development was surveyed and analyzed. In the viewpoint of analysis of the changes in the global policy environment surrounding nuclear technology development and development of national nuclear R and D strategy, this study (1) analyzed trends of nuclear technology policies and (2) developed the nuclear energy R and D innovation strategies. To put it in more detail, each subject was further explored as follows; (1) themes to analyze trends of nuclear policies: nuclear Renaissance and forecast for nuclear power plant, International collaboration for advanced nuclear technologies in GIF, INPRO and I-NERI, The present situation and outlook for world uranium market (2) themes to develop of nuclear energy R and D innovation strategies: The mid-term strategy plan of the KAERI, The technological innovation case of the KAERI.

  11. Statewide evaluation of local wellness policies in Georgia: an examination of policy compliance, policy strength, and associated factors.

    Science.gov (United States)

    Lyn, Rodney; O'Meara, Sandra; Hepburn, Valerie A; Potter, Anna

    2012-01-01

    To analyze relationships between demographic characteristics of Georgia school systems and: (1) compliance with the Child Nutrition and WIC Reauthorization Act (CNRA); and (2) strength of wellness policy goals in nutrition, physical activity, and other school-based activities. Each local school district submitted their school-board-approved wellness policy to researchers. Each policy was reviewed and coded for compliance with CNRA and evaluated on the strength of its goals. Public school districts. One hundred seventy-six of 180 Georgia public school systems participated. Independent variables were demographic characteristics of Georgia school systems. Dependent variables were ratings from the policy evaluation instrument, grouped into composite indices to compare the strength (ie, ratings) of wellness policy goals. Pearson correlation, cross-tabulation. Significant positive associations were found between academic performance and: strength of overall wellness policy goals (P policy goals and stronger goals in nutrition education and other school-based activities. Copyright © 2012 Society for Nutrition Education and Behavior. Published by Elsevier Inc. All rights reserved.

  12. Climate policy in India: what shapes international, national and state policy?

    Science.gov (United States)

    Atteridge, Aaron; Shrivastava, Manish Kumar; Pahuja, Neha; Upadhyay, Himani

    2012-01-01

    At the international level, India is emerging as a key actor in climate negotiations, while at the national and sub-national levels, the climate policy landscape is becoming more active and more ambitious. It is essential to unravel this complex landscape if we are to understand why policy looks the way it does, and the extent to which India might contribute to a future international framework for tackling climate change as well as how international parties might cooperate with and support India's domestic efforts. Drawing on both primary and secondary data, this paper analyzes the material and ideational drivers that are most strongly influencing policy choices at different levels, from international negotiations down to individual states. We argue that at each level of decision making in India, climate policy is embedded in wider policy concerns. In the international realm, it is being woven into broader foreign policy strategy, while domestically, it is being shaped to serve national and sub-national development interests. While our analysis highlights some common drivers at all levels, it also finds that their influences over policy are not uniform across the different arenas, and in some cases, they work in different ways at different levels of policy. We also indicate what this may mean for the likely acceptability within India of various climate policies being pushed at the international level.

  13. Assessment of Policy Integration of Sustainable Consumption and Production into National Policies

    Directory of Open Access Journals (Sweden)

    Ryu Koide

    2017-09-01

    Full Text Available Sustainable Consumption and Production (SCP was adopted as a stand-alone goal and reflected as one of the cross-cutting objectives of the Sustainable Development Goals (SDGs, with a central role to address global resource consumption and its associated environmental impacts, as well as numerous social and economic issues. With this broad characterization of SCP, policy integration is crucial in addressing it at national level. This paper analyzes characteristics of SCP policy integration based on a survey of national government policies. It reveals that SCP is not fully integrated in national policy-making; high resource consumption sectors such as urban planning, building, and tourism are not fully incorporated into national SCP policies, and there is only limited participation of relevant government ministries other than environment ministries. We find that among countries with horizontal policy integration, those with Green Economy/Green Growth frameworks tend to have better sectoral integration; and those with SCP-specific frameworks are likely to have broader coordination of ministries. By conducting cross-analysis using income level and region, the different characteristics of SCP policy-making approaches were identified. The results of this study provide a better understanding of how SCP is integrated into policy for effective national policy-making and measurement of the SDG Goal 12.

  14. Management of science policy, sociology of science policy and economics of science policy

    CERN Document Server

    Ruivo, Beatriz

    2017-01-01

    'Management of science policy, sociology of science policy and economics of science policy' is a theoretical essay on the scientific foundation of science policy (formulation, implementation, instruments and procedures). It can be also used as a textbook.

  15. Language Policy and Communication Policy - Same Same but Different?

    DEFF Research Database (Denmark)

    Bergenholtz, Henning; Johnsen, Mia

    2006-01-01

    Surprisingly, no attempts have yet been made to relate language policy and communication policy. This is the case in theoretical contributions on language policy and theoretical contributions on communication policy alike, none of which mentions the other concept. It is also the case in existing...... language policies where the term communication policy is not mentioned at all. Likewise, the term language policy is not found in communication policies, even where a particular company or organisation has a language policy as well as a communication policy. This contribution aims to define both terms...

  16. Energy policy in transport and transport policy

    International Nuclear Information System (INIS)

    Van Dender, Kurt

    2009-01-01

    Explanations for, and indirect evidence of, imperfections in the market for private passenger vehicle fuel economy suggest there is a reasonable case for combining fuel economy standards and fuel or carbon taxes to contribute to an energy policy that aims to reduce greenhouse gas emissions and improve energy security. Estimates of key elasticities, including the rebound effect, indicate that the positive and negative side-effects of fuel economy measures on transport activities and external costs are limited. However, an energy policy for transport does not replace a transport policy that aims to manage the main transport externalities including congestion and local pollution. Conventional marginal cost estimates and standard cost-benefit reasoning suggest that policies that address congestion and local pollution likely bring benefits at least as large as those from fuel economy measures. But the large uncertainty on the possible effects of greenhouse gas emissions constitutes a strong challenge for standard cost-benefit reasoning. Emerging results from methods to cope with this uncertainty suggest that policies to stimulate the widespread adoption of low-carbon technologies in transport are justified.

  17. Policy Analysis of Road Traffic Injury Prevention in Iran

    Science.gov (United States)

    Azami-Aghdash, Saber; Gorji, Hassan Abolghasem; Shabaninejad, Hosein; Sadeghi-Bazargani, Homayoun

    2017-01-01

    Introduction Due to the large number of Road Traffic Injuries (RTIs) in Iran, authorities have implemented a number of policies for the prevention of RTIs. However, a scientific analysis of these policies has thus far been neglected. Therefore, this study was conducted for policy analysis of RTIs prevention in Iran. Methods This qualitative study with a case study approach was conducted in Iran during 2016 in two phases: First, by reviewing literature and documents of the past ten years, policies that have been executed to prevent RTIs in Iran were identified. In the second phase of the study, the identified policies were ranked by prioritization matrices. The two policies with the highest scores were selected. ‘Policy triangle framework’ was used for Policy analyzing. Stakeholders of these policies (42 people) were interviewed. Data were analyzed manually by implementing Content-Analysis methods. Results The policies of “pupil liaisons” and “safety belt” were selected for analysis from thirteen potential identified polices. The results of some studies revealed that safety belts had not been properly used in Iran (less than 80%). There was an eight-year hiatus between the approval of the safety belts policy and implementation of this policy. Eight actors were identified for safety belts policy. Lack of diligence in implementation of the policy, failing to pay adequate attention to education and the culture of driving, and failing to select an organization for the implementation of the policy, were identified as the main weaknesses of this policy. For ‘pupil liaisons’ policy, five actors were identified. Following the implementation of this policy, the number of penalties was reduced (17.9%). Neglecting scientific findings and individual-based nature of the policy were identified as the primary weaknesses of this policy. Conclusions Taking serious measures to properly execute the policy, educating people, selecting an efficient organization that is

  18. Beyond the contributory principle: changes and continuities in Argentine social policy , 2003-2011

    Directory of Open Access Journals (Sweden)

    Guillermo V Alonso

    2015-01-01

    Full Text Available The goal of this article is to analyze the transformations of Argentine social policy during Nestor Kirchner’s and Cristina Fernandez’s Administrations, from 2003 through 2011. We analyze the main social policies with more extended population coverage, especially social security programs. We will argue that at the beginning social policies were a new version of the Bismarckian social insurance, but then the government innovated in social policy breaking with the contributory principle.

  19. ROMANIAN INVESTMENT POLICY ANALYSIS

    Directory of Open Access Journals (Sweden)

    Hategan Anca

    2011-07-01

    Full Text Available Starting with the year 2009, the European Union, as well as the rest of the world, was affected by the economic and financial crisis, and one of the effects reflected in the decrease of foreign direct investment (FDI projects and also in the reduction of their host locations. Creating a healthy economic environment, that should be efficient for any form of international investment , represents the nowadays challenge of all market economies. This paper concentrates on analyzing our country’s attractiveness from the international investor’s point of view, it also focuses on the Romanian investment policy, its investment climate, as well as on identifying or valuating the strengths and opportunities offered by Romania. The advantages of the foreign direct investments are universally recognized and they basically include the expansion of the production capacity and income, job creation, technologically diffusion and economic development. Creating an appropriate economic environment, that is efficient for any form of international investments represents the nowadays challenge of all market economies. OECD member states experience, for example, outlines the advantages of a functional legal and normative climate, based on the principles of transparency and non discrimination, that are essential for attracting foreign investments. In the actual competition for attracting FDI, every state tries to offer as many incentives to the future foreign investors. The Romanian investment policy sets out incentives in a non-discriminatory and transparent way offering the investors the specific criteria. The Romanian business environment has improved significantly in recent years, driven in particular by EU accession. Major progress has been recorded in areas such as the fiscal environment, rule of law, the fight against corruption and property registration. When considering our country a possible location for the development of their businesses, the foreign

  20. Shaping Policy Curves

    DEFF Research Database (Denmark)

    Broome, André; Seabrooke, Leonard

    2015-01-01

    provide a conceptual framework for understanding how IOs seek to use their own cognitive authority to foster ‘diagnostic coordination’ across technocratic economic policy communities. This encourages officials to adapt to a common policy language and delimits the policy space within which they identify......International organizations (IOs) such as the International Monetary Fund and the World Bank are assumed to rely on ‘sympathetic interlocutors’ at the national level to drive through economic reforms that conform to global policy norms. In this article we answer the following question: How do...... sympathetic interlocutors for IOs emerge in the first place? We address this question by examining how IOs engage in teaching norms to national officials via transnational policy training in order to increase the number of domestic reformers who are sympathetic to their prescriptions for policy change. We...

  1. Trends in U.S. nuclear policy

    International Nuclear Information System (INIS)

    Potter, W.C.

    2005-01-01

    To further the debate on complex issues that involve technical, regional, and strategic aspects, Ifri Security Studies Department organizes each year, in collaboration with the Atomic Energy Commission, a series of closed seminars dealing with WMD proliferation, disarmament, and non-proliferation. The Proliferation Papers is a collection, in the original version, of selected texts from these presentations. The following text is based on a presentation given by William C. Potter at Ifri on March 15, 2005. The author analyzes and discusses the following topics: declaratory policy, which may or may not correspond closely with, arms control and nonproliferation policy, which also should but does not always appear to be highly correlated with either, targeting and Employment policy and/or force modernization and research and development policy. (A.L.B.)

  2. Determinants of corporate dividend policy in Indonesia

    Science.gov (United States)

    Lestari, H. S.

    2018-01-01

    This study aims to investigate the determinants factors that effect the dividend policy. The sample used in this research is manufacture companies listed in Indonesia Stock Exchange (IDX) and the period 2011 - 2015. There are independent variables such as earning, cash flow, free cash flow, debt, growth opportunities, investment opportunities, firm size, largest shareholder, firm risk, lagged dividend and dividend policy used as dependent variable. The study examines a total of 32 manufacture companies. After analyzing the data using the program software Eviews 9.0 by multiples regression analysis reveal that earning, cash flow, free cash flow, firm size, and lagged dividend have significant effect on dividend policy, whereas debt, growth opportunities, investment opportunities, largest shareholder, and firm risk have no significant effect on dividend policy. The results of this study are expected to be implemented by the financial managers in improving corporate profits and basic information as return on investment decisions.

  3. THE ROOTS OF MACROPRUDENTIAL POLICY AND THE RISK-TAKING CHANNEL OF MONETARY POLICY

    Directory of Open Access Journals (Sweden)

    Hernán Alzate

    2017-12-01

    Full Text Available Purpose: the main objective of this manuscript is to confirm that since there is a direct link between macroprudential policies and monetary policy, it is worthwhile to analyze the inter-dependence with the risk-taking channel. Methodology: the analysis presented in this manuscript is based on an extensive literature review from reliable sources in order to support the research findings. Findings: The empirical research about macroprudential policies, as well as the conventional and unconventional monetary policies adopted by central banks since the 2008 financial crisis could be expanded by adding the credit shock and including Emerging Economies as part of the analysis. This interesting phenomenon could be investigated by estimating spillover effects associated to Advanced Economies’ monetary and prudential policies on Emerging Economies’ risk-taking channel.

  4. Public health professionals as policy entrepreneurs: Arkansas's childhood obesity policy experience.

    Science.gov (United States)

    Craig, Rebekah L; Felix, Holly C; Walker, Jada F; Phillips, Martha M

    2010-11-01

    In response to a nationwide rise in obesity, several states have passed legislation to improve school health environments. Among these was Arkansas's Act 1220 of 2003, the most comprehensive school-based childhood obesity legislation at that time. We used the Multiple Streams Framework to analyze factors that brought childhood obesity to the forefront of the Arkansas legislative agenda and resulted in the passage of Act 1220. When 3 streams (problem, policy, and political) are combined, a policy window is opened and policy entrepreneurs may advance their goals. We documented factors that produced a policy window and allowed entrepreneurs to enact comprehensive legislation. This historical analysis and the Multiple Streams Framework may serve as a roadmap for leaders seeking to influence health policy.

  5. Public and policy maker support for point-of-sale tobacco policies in New York.

    Science.gov (United States)

    Schmitt, Carol L; Juster, Harlan R; Dench, Daniel; Willett, Jeffrey; Curry, Laurel E

    2014-01-01

    To compare public and policy maker support for three point-of-sale tobacco policies. Two cross-sectional surveys--one of the public from the New York Adult Tobacco Survey and one of policy makers from the Local Opinion Leader Survey; both collected and analyzed in 2011. Tobacco control programs focus on educating the public and policy makers about tobacco control policy solutions. Six hundred seventy-six county-level legislators in New York's 62 counties and New York City's five boroughs (response rate: 59%); 7439 New York residents aged 18 or older. Landline response rates: 20.2% to 22%. Cell phone response rates: 9.2% to 11.1%. Gender, age, smoking status, presence of a child aged 18 years or younger in the household, county of residence, and policy maker and public support for three potential policy solutions to point-of-sale tobacco marketing. t-tests to compare the demographic makeup for the two samples. Adjusted Wald tests to test for differences in policy support between samples. The public was significantly more supportive of point-of-sale policy solutions than were policy makers: cap on retailers (48.0% vs. 19.2%, respectively); ban on sales at pharmacies (49.1% vs. 38.8%); and ban on retailers near schools (53.3% vs. 42.5%). cross-sectional data, sociodemographic differences, and variations in item wording. Tobacco control programs need to include information about implementation, enforcement, and potential effects on multiple constituencies (including businesses) in their efforts to educate policy makers about point-of-sale policy solutions.

  6. Evaluating a traditional medicine policy in South Africa: phase 1 development of a policy assessment tool

    Directory of Open Access Journals (Sweden)

    Georgios Gavriilidis

    2012-05-01

    Full Text Available Background: Policies that empower individuals and communities may be appropriate for public health, and more broadly. Simple, transparent and acceptable tools are therefore required to evaluate policies from an empowerment perspective. In 2008, the South African Department of Health (DOHSA drafted a policy to endorse the integration of African Traditional Medicine (ATM into the public health sector, following the World Health Organization's (WHO long-standing directives. Objective: The purpose of this study is to critically analyze this policy using a novel evaluation tool. Design: A 12-point ‘Policy Empowerment Index’ (PEI is introduced, and used to classify and score the policy according to five theoretical policy types. The evaluation was based on a stepwise review and associated publications: policy drafts, policy statements and news announcements. Results: According to the assessment tool, the ATM policy was marginally ‘supportive’ of constituent empowerment, although several ‘directive’ features were also observed. The importance of ATM to SA's communities and the promotion of education, employment, entrepreneurship and peripheral resource mobilization were the main empowering elements. Centralised conception, planning and implementation, the absence of provisions for local adaptations and the authoritative legislation context were sub-optimal features. Conclusions: South Africa's ATM legislation may need to further involve communities in policy design and implementation to capitalise upon the broader benefits of community empowerment. However, the iterative nature of method and evaluation is important. Indeed, they are proposed as points to initiate participatory development, and improve policy evaluation . Such instruments can empower constituents in the political process.

  7. Environmental Policy Law

    International Nuclear Information System (INIS)

    Lee, Sang Don

    1985-03-01

    This book tell US environmental problems and environmental conservation, theory with present situation of the problems, influence of environmental aggravation, and cause of environmental problems, environmental policy influencing environment such as the national environmental policy act in America, and the role of court and environmental policy act, jurisdiction investigation about administrative action which influence on environment, and standard of jurisdiction investigation in environmental problems and legislation of environmental rights.

  8. Counterterrorism policy in Colombia

    OpenAIRE

    Self, Kevin A.

    2007-01-01

    The purpose of this thesis is to suggest a coherent, credible, and long-term counterterrorism policy in Colombia. The events of September 11, 2001 heightened U.S. awareness of Colombian terrorist organizations, the most powerful being the Revolutionary Armed Forces of Colombia (FARC). The U.S. counterterror approach in Colombia appears fragmented, with only minor changes to its previous drug control policies. In contrast, the Colombian government has developed and implemented a policy to ...

  9. Pension Fund Investment Policy

    OpenAIRE

    Zvi Bodie

    1988-01-01

    The purpose of this paper is to survey what is known about the investment policy of pension funds. Pension fund investment policy depends critically on the type of plan: defined contribution versus defined benefit. For defined contribution plans investment policy is not much different than it is for an individual deciding how to invest the money in an Individual Retirement Account (IRA). The guiding principle is efficient diversification, that is, achieving the maximum expected return for any...

  10. Financial Imbalances and Macro-prudential Policies

    Directory of Open Access Journals (Sweden)

    Polikarpova Olga S.

    2015-11-01

    -prudential policy of central banks has been considered, financial imbalances of the EMS since 1999 have been analyzed, the main macro-prudential instruments have been described and EMS countries that had implemented these instruments have been considered. The efficiency of using the main macro-prudential instruments in the extrapolation at mitigating symptoms of systemic risk has been analyzed. The directions of the interaction between macro-prudential and monetary and credit policy in the EMU have been identified. The problem of macro-prudential migration, which may cause a new threat of financial asymmetry in the EMU has been considered.

  11. Turkey and Iran Transcaucasia Policy: Comparative Analysis

    Directory of Open Access Journals (Sweden)

    А V Suleimanov

    2010-03-01

    Full Text Available Turkey and Iran Transcaucasia modern foreign policy is analyzed. As is known, Turkey and Iran historically were the competing parties for spheres of influence in Transcaucasia, as well as Russia, the USA and the Great Britain. Regional relations between Azerbaijan, Armenia and Georgia are discussed in context of Nagorno-Karabakh and Georgia-South Ossetia conflicts and Caspian problem.

  12. Energy policy in a changing social order

    Energy Technology Data Exchange (ETDEWEB)

    Schaller, D.A.

    1981-01-01

    In this paper, the background of energy management and use relative to public policymaking is reviewed. Many of the more-prominent social cross currents, such as: consumerism, resistance to nuclear power, tax rebellion, etc., are identified and described. Conventional and alternate energy policy options are analyzed. 41 refs.

  13. The Political Economics of Policy Centralization

    NARCIS (Netherlands)

    Roelfsema, H.J.

    2006-01-01

    The aim of this thesis is to get a better understanding of how centralization affects the efficiency of policy making. To analyze this, the chapters in this thesis deal with political incentive problems. The chapters have in common a set of assumptions on the institutional setting in which

  14. Government Research and Development Policy for Telecommunications.

    Science.gov (United States)

    Cohen, Linda

    This paper investigates how recent changes in the telecommunications industry are likely to affect government research and development policies by analyzing how changes in the market structure--in particular, increased competition in the industry due to domestic deregulation and international competition--change the political economy of government…

  15. Translational medicine policy issues in infectious disease.

    NARCIS (Netherlands)

    Fears, R.; Meer, J.W.M. van der; Meulen, V. ter

    2010-01-01

    The European Academies Science Advisory Council has published a series of reports on infectious disease policy issues, analyzing priorities for building the science base as part of public health strategy. Among current challenges facing the European Union are the needs to tackle antibiotic

  16. Tobacco control policies.

    Science.gov (United States)

    Bialous, Stella Aguinaga; Kaufman, Nancy; Sarna, Linda

    2003-11-01

    To review and summarize tobacco control policies, their impact in curbing the tobacco epidemic, and to describe a role for nursing advocacy. Published articles and research studies. Comprehensive tobacco control policy is one of the most effective mechanisms to prevent tobacco-related cancers and other illnesses. The World Health Organization's Framework Convention on Tobacco Control, and the Master Settlement Agreement in the United States have provided new opportunities for tobacco control. Nursing participation in the policy process can expand and strengthen these policies' activities. Involvement in tobacco control should be integral to oncology nursing efforts to prevent cancer, promote health, and quality of life.

  17. Australian uranium mining policy

    International Nuclear Information System (INIS)

    Fisk, B.

    1985-01-01

    Australian government policy is explained in terms of adherence to the Non-Proliferation Treaty. Two alleged uncertainties are discussed: the future of Australian mining industry as a whole -on which it is said that Australian uranium mines will continue to be developed; and detailed commercial policy of the Australian government - on which it is suggested that the three-mines policy of limited expansion of the industry would continue. Various aspects of policy, applying the principles of the NPT, are listed. (U.K.)

  18. Collaborative Policy Innovation

    DEFF Research Database (Denmark)

    Sørensen, Eva; Waldorff, Susanne Boch

    2014-01-01

    Governments all over the Western world currently face wicked problems that call for policy innovation. A new strand of research in public innovation points to collaboration between public authorities and relevant and affected stakeholders as an important driver of public innovation. A case study...... of collaborative policy innovation in the area of mental health care in Denmark indicates that collaboration can contribute to qualify the politicians’ understanding of wicked policy problems, and to fostering new creative policy solutions. The study also shows, however, that the new problem understandings...

  19. Policy entrepreneurship and policy networks in healthcare systems - the case of Israel's pediatric dentistry reform.

    Science.gov (United States)

    Cohen, Nissim; Horev, Tuvia

    2017-01-01

    Can the entry of a policy entrepreneur challenge the equilibrium of a policy network and promote changes that might clash with the goals of powerful civil-servants and/or interest groups and, if so, why and how? Our goal is to examine two sides of the same coin: how does an in-depth analysis of Israel's dental care reform enrich our understanding of policy networks and policy entrepreneurship? Second, how does the literature on policy networks and policy entrepreneurship help us understand this reform? Based on a theoretical framework that appears in the literature of policy entrepreneurship and policy networks, we analyze the motivations, goals and strategies of the main actors involved in the process of reforming pediatric dental care in Israel. We demonstrate how a policy entrepreneur navigated within a policy network and managed to promote a reform that, until his appearance, no one else in that network had succeeded in enacting. Our goals are advanced through a case study of a reform in pediatric dentistry implemented in Israel in 2010. It rests on textual analyses of the literature, reports, committee minutes, parliamentary proceedings, print and online media, and updates in relevant legislation and case law between 2009 and 2015. In addition, the case study draws on the insights of one of the authors (TH), who played a role in the reform process. Historical circumstances and the Israeli public's longstanding lack of interest in changing the existing model as well as interest groups that preferred the dominance of the private sector in the dental healthcare system kept that area out of the services supplied, universally, under the National Health Insurance Law. This situation changed significantly following the publication in 2007 of a policy analysis that contributed to shifts in the motivations and balance of power within the policy network, which in turn prepared the ground for a policy change. In this environment a determined policy entrepreneur, who

  20. A framework to analyze emissions implications of ...

    Science.gov (United States)

    Future year emissions depend highly on the evolution of the economy, technology and current and future regulatory drivers. A scenario framework was adopted to analyze various technology development pathways and societal change while considering existing regulations and future uncertainty in regulations and evaluate resulting emissions growth patterns. The framework integrates EPA’s energy systems model with an economic Input-Output (I/O) Life Cycle Assessment model. The EPAUS9r MARKAL database is assembled from a set of technologies to represent the U.S. energy system within MARKAL bottom-up technology rich energy modeling framework. The general state of the economy and consequent demands for goods and services from these sectors are taken exogenously in MARKAL. It is important to characterize exogenous inputs about the economy to appropriately represent the industrial sector outlook for each of the scenarios and case studies evaluated. An economic input-output (I/O) model of the US economy is constructed to link up with MARKAL. The I/O model enables user to change input requirements (e.g. energy intensity) for different sectors or the share of consumer income expended on a given good. This gives end-users a mechanism for modeling change in the two dimensions of technological progress and consumer preferences that define the future scenarios. The framework will then be extended to include environmental I/O framework to track life cycle emissions associated

  1. Analyzing Music Services Positioning Through Qualitative Research

    Directory of Open Access Journals (Sweden)

    Manuel Cuadrado

    2015-12-01

    Full Text Available Information technologies have produced new ways of distributing and consuming music, mainly by youth, in relation to both goods and services. In the case of goods, there has been a dramatic shift from traditional ways of buying and listening to music to new digital platforms. There has also been an evolution in relation to music services. In this sense, live music concerts have been losing their audiences over the past few years, as have music radio stations, in favor of streaming platforms. Curious about this phenomenon, we conducted an exploratory research in order to analyze how all these services, both traditional and new ones were perceived. Specifically, we aimed to study youth´s assessment of the three most relevant music service categories: music radio stations, digital streaming platforms, and pop-rock music festivals. To do so, we used the projective technique of image association to gather information. The population of the study consisted of individuals between 18 and 25 years of age. Our results, after using content analysis, were poor due to spontaneous recall. Therefore, we duplicated the study, but in a more focus-oriented way. Information gathered this time allowed us not only to better know how all these organizations are positioned but also to obtain a list of descriptors to be used in a subsequent descriptive research study.

  2. PSAIA – Protein Structure and Interaction Analyzer

    Directory of Open Access Journals (Sweden)

    Vlahoviček Kristian

    2008-04-01

    Full Text Available Abstract Background PSAIA (Protein Structure and Interaction Analyzer was developed to compute geometric parameters for large sets of protein structures in order to predict and investigate protein-protein interaction sites. Results In addition to most relevant established algorithms, PSAIA offers a new method PIADA (Protein Interaction Atom Distance Algorithm for the determination of residue interaction pairs. We found that PIADA produced more satisfactory results than comparable algorithms implemented in PSAIA. Particular advantages of PSAIA include its capacity to combine different methods to detect the locations and types of interactions between residues and its ability, without any further automation steps, to handle large numbers of protein structures and complexes. Generally, the integration of a variety of methods enables PSAIA to offer easier automation of analysis and greater reliability of results. PSAIA can be used either via a graphical user interface or from the command-line. Results are generated in either tabular or XML format. Conclusion In a straightforward fashion and for large sets of protein structures, PSAIA enables the calculation of protein geometric parameters and the determination of location and type for protein-protein interaction sites. XML formatted output enables easy conversion of results to various formats suitable for statistic analysis. Results from smaller data sets demonstrated the influence of geometry on protein interaction sites. Comprehensive analysis of properties of large data sets lead to new information useful in the prediction of protein-protein interaction sites.

  3. Analyzing Architecture of Mithraism Rock Temples

    Directory of Open Access Journals (Sweden)

    Zohre AliJabbari

    2017-06-01

    Full Text Available This analyzes the architecture of rock temples of West and Northwest of Iran, as well as factors influencing their formation. The creation of rock architecture in this area of Iran is influenced by the religious, geographical and political atmosphere of their time. Most of these structures are formed by dominated empires in the first millennium BC. And in some works we are observing their continuity in later periods and change in their functions. One of the reasons that have attracted man to mountain and rock in different schools was the religious structure of community. According to the sanctity of mountains and rocks in the ancient religions, especially in Mithraism, valuable temples and places of worship have emerged in the mountains. Their obvious characteristic is circular dome-shaped spaces; simplicity, arrangement of spaces and the way of creating light that correspond with the tradition of Mithraism in Iran. Mehr Temple in Maragheh, Dashkasan in Zanjan, and Qadamgah Temple in Azarshahr are the rock temples in northwest of Iran that signs and symbols on them indicate the performance of Mithraism duties in these temples. In the West of Iran, Cogan cave in Lorestan, considering the characteristics of Mithraism temples, in a period had function as a temple for the worship of Mithra. This research investigates architectural futures of these temples.

  4. Analyzing the Existing Undergraduate Engineering Leadership Skills

    Directory of Open Access Journals (Sweden)

    Hamed M. Almalki

    2016-12-01

    Full Text Available Purpose: Studying and analyzing the undergraduate engineering students' leadership skills to discover their potential leadership strengths and weaknesses. This study will unveil potential ways to enhance the ways we teach engineering leadership. The research has great insights that might assist engineering programs to improve curricula for the purpose of better engineering preparation to meet industry's demands. Methodology and Findings: 441 undergraduate engineering students have been surveyed in two undergraduate engineering programs to discover their leadership skills. The results in both programs were revealing that undergraduate engineering students are lacking behind in the visionary leadership skills compared to directing, including and cultivating leadership styles. Recommendation: A practical framework has been proposed to enhance the lacking leadership skills by utilizing the Matrix of Change (MOC, and the Balanced Scorecard BSC to capture the best leadership scenarios to design virtual simulation environment as per the lacking leadership skills which is the visionary leadership skills in this case. After that, the virtual simulation will be used to provide an experiential learning by replacing human beings with avatars that can be managed or dramatized by real people to enable the creation of live, practical, measurable, and customizable leadership development programs.

  5. Analyzing human errors in flight mission operations

    Science.gov (United States)

    Bruno, Kristin J.; Welz, Linda L.; Barnes, G. Michael; Sherif, Josef

    1993-01-01

    A long-term program is in progress at JPL to reduce cost and risk of flight mission operations through a defect prevention/error management program. The main thrust of this program is to create an environment in which the performance of the total system, both the human operator and the computer system, is optimized. To this end, 1580 Incident Surprise Anomaly reports (ISA's) from 1977-1991 were analyzed from the Voyager and Magellan projects. A Pareto analysis revealed that 38 percent of the errors were classified as human errors. A preliminary cluster analysis based on the Magellan human errors (204 ISA's) is presented here. The resulting clusters described the underlying relationships among the ISA's. Initial models of human error in flight mission operations are presented. Next, the Voyager ISA's will be scored and included in the analysis. Eventually, these relationships will be used to derive a theoretically motivated and empirically validated model of human error in flight mission operations. Ultimately, this analysis will be used to make continuous process improvements continuous process improvements to end-user applications and training requirements. This Total Quality Management approach will enable the management and prevention of errors in the future.

  6. Complete denture analyzed by optical coherence tomography

    Science.gov (United States)

    Negrutiu, Meda L.; Sinescu, Cosmin; Todea, Carmen; Podoleanu, Adrian G.

    2008-02-01

    The complete dentures are currently made using different technologies. In order to avoid deficiencies of the prostheses made using the classical technique, several alternative systems and procedures were imagined, directly related to the material used and also to the manufacturing technology. Thus, at the present time, there are several injecting systems and technologies on the market, that use chemoplastic materials, which are heat cured (90-100°C), in dry or wet environment, or cold cured (below 60°C). There are also technologies that plasticize a hard cured material by thermoplastic processing (without any chemical changes) and then inject it into a mold. The purpose of this study was to analyze the existence of possible defects in several dental prostheses using a non invasive method, before their insertion in the mouth. Different dental prostheses, fabricated from various materials were investigated using en-face optical coherence tomography. In order to discover the defects, the scanning was made in three planes, obtaining images at different depths, from 0,01 μm to 2 mm. In several of the investigated prostheses we found defects which may cause their fracture. These defects are totally included in the prostheses material and can not be vizualised with other imagistic methods. In conclusion, en-face OCT is an important investigative tool for the dental practice.

  7. Update on the USNRC's nuclear plant analyzer

    International Nuclear Information System (INIS)

    Laats, E.T.

    1987-01-01

    The Nuclear Plant Analyzer (NPA) is the U.S. Nuclear Regulatory Commission's (NRC's) state-of-the-art nuclear reactor simulation capability. This computer software package integrates high fidelity nuclear reactor simulation codes such as the TRAC and RELAPS series of codes with color graphics display techniques and advanced workstation hardware. An overview of this program was given at the 1984 Summer Computer Simulation Conference (SCSC), with selected topics discussed at the 1985 and 1986 SCSCs. This paper addresses these activities and related experiences. First, The Class VI computer implementation is discussed. The trade-offs between gaining significantly greater computational speed and central memory, with the loss of performance due to many more simultaneous users is shown. Second, the goal of the super-minicomputer implementation is to produce a very cost-effective system that utilizes advanced (multi-dimensional, two-phase coolant) simulation capabilities at real wall-clock simulation times. Benchmarking of the initial super-minicomputer implementation is discussed. Finally, the technical and economic feasibility is addressed for implementing the super-minicomputer version of the NPA with the RELAPS simulation code onto the Black Fox full scope nuclear power plant simulator

  8. Analyzing Spatiotemporal Anomalies through Interactive Visualization

    Directory of Open Access Journals (Sweden)

    Tao Zhang

    2014-06-01

    Full Text Available As we move into the big data era, data grows not just in size, but also in complexity, containing a rich set of attributes, including location and time information, such as data from mobile devices (e.g., smart phones, natural disasters (e.g., earthquake and hurricane, epidemic spread, etc. We are motivated by the rising challenge and build a visualization tool for exploring generic spatiotemporal data, i.e., records containing time location information and numeric attribute values. Since the values often evolve over time and across geographic regions, we are particularly interested in detecting and analyzing the anomalous changes over time/space. Our analytic tool is based on geographic information system and is combined with spatiotemporal data mining algorithms, as well as various data visualization techniques, such as anomaly grids and anomaly bars superimposed on the map. We study how effective the tool may guide users to find potential anomalies through demonstrating and evaluating over publicly available spatiotemporal datasets. The tool for spatiotemporal anomaly analysis and visualization is useful in many domains, such as security investigation and monitoring, situation awareness, etc.

  9. NRC plant-analyzer development at BNL

    International Nuclear Information System (INIS)

    Wulff, W.

    1983-01-01

    The objective of this program is to develop an LWR engineering plant analyzer capable of performing realistic and accurate simulations of plant transients and Small-Break Loss of Coolant Accidents at real-time and faster than real-time computing speeds and at low costs for preparing, executing and evaluating such simulations. The program is directed toward facilitating reactor safety analyses, on-line plant monitoring, on-line accident diagnosis and mitigation and toward improving reactor operator training. The AD10 of Applied Dynamics International, Ann Arbor, MI, a special-purpose peripheral processor for high-speed systems simulation, is programmed through a PDP-11/34 minicomputer and carries out digital simulations with analog hardware in the input/output loop (up to 256 channels). Analog signals from a control panel are being used now to activate or to disable valves and to trip pump drive motors or regulators without interrupting the simulation. An IBM personal computer with multicolor graphics capabilities and a CRT monitor are used to produce on-line labelled diagrams of selected plant parameters as functions of time

  10. Analyzing Design Heating Loads in Superinsulated Buildings

    Energy Technology Data Exchange (ETDEWEB)

    Arena, Lois [Consortium for Advanced Residential Buildings, Norwalk, CT (United States)

    2015-06-16

    The U.S. Department of Energy’s Building America research team Consortium for Advanced Residential Buildings (CARB) worked with the EcoVillage cohousing community in Ithaca, New York, on the Third Residential EcoVillage Experience neighborhood. This communityscale project consists of 40 housing units—15 apartments and 25 single-family residences. Units range in size from 450 ft2 to 1,664 ft2 and cost from $80,000 for a studio apartment to $235,000 for a three- or four-bedroom single-family home. For the research component of this project, CARB analyzed current heating system sizing methods for superinsulated homes in cold climates to determine if changes in building load calculation methodology should be recommended. Actual heating energy use was monitored and compared to results from the Air Conditioning Contractors of America’s Manual J8 (MJ8) and the Passive House Planning Package software. Results from that research indicate that MJ8 significantly oversizes heating systems for superinsulated homes and that thermal inertia and internal gains should be considered for more accurate load calculations.

  11. Analyzing dialect variation in historical speech corpora.

    Science.gov (United States)

    Renwick, Margaret E L; Olsen, Rachel M

    2017-07-01

    The Linguistic Atlas of the Gulf States is an extensive audio corpus of sociolinguistic interviews with 1121 speakers from eight southeastern U.S. states. Complete interviews have never been fully transcribed, leaving a wealth of phonetic information unexplored. This paper details methods for large-scale acoustic analysis of this historical speech corpus, providing a fuller picture of Southern speech than offered by previous impressionistic analyses. Interviews from 10 speakers (∼36 h) in southeast Georgia were transcribed and analyzed for dialectal features associated with the Southern Vowel Shift and African American Vowel Shift, also considering the effects of age, gender, and race. Multiple tokens of common words were annotated (N = 6085), and formant values of their stressed vowels were extracted. The effects of shifting on relative vowel placement were evaluated via Pillai scores, and vowel dynamics were estimated via functional data analysis and modeled with linear mixed-effects regression. Results indicate that European American speakers show features of the Southern Vowel Shift, though certain speakers shift in more ways than others, and African American speakers' productions are consistent with the African American Vowel Shift. Wide variation is apparent, even within this small geographic region, contributing evidence of the complexity of Southern speech.

  12. Numerical methods for analyzing electromagnetic scattering

    Science.gov (United States)

    Lee, S. W.; Lo, Y. T.; Chuang, S. L.; Lee, C. S.

    1985-01-01

    Attenuation properties of the normal modes in an overmoded waveguide coated with a lossy material were analyzed. It is found that the low-order modes, can be significantly attenuated even with a thin layer of coating if the coating material is not too lossy. A thinner layer of coating is required for large attenuation of the low-order modes if the coating material is magnetic rather than dielectric. The Radar Cross Section (RCS) from an uncoated circular guide terminated by a perfect electric conductor was calculated and compared with available experimental data. It is confirmed that the interior irradiation contributes to the RCS. The equivalent-current method based on the geometrical theory of diffraction (GTD) was chosen for the calculation of the contribution from the rim diffraction. The RCS reduction from a coated circular guide terminated by a PEC are planned schemes for the experiments are included. The waveguide coated with a lossy magnetic material is suggested as a substitute for the corrugated waveguide.

  13. Analyzing the Pension System of the USSR

    Directory of Open Access Journals (Sweden)

    Aleksei V. Pudovkin

    2015-01-01

    Full Text Available The article under the title "ANALYSIS OF THE PENSION SYSTEM OF THE USSR" deals with numerous aspects of development of the pension system of the former USSR. Since the improvement of the Russian pension system is presently high on the agenda, the author believes that analyzing the own historical experience in the first line is essential in order to create a sound and efficient pension system in Russia. The study presented in the article aims to execute an in-depth analysis of legislature on the soviet pension system with the view to recreate the architecture of the pension system of the USSR. In addition, the study also reflects on the official statistics for the said period to make a qualified and fundamental conclusion on the efficiency of the soviet pension system. The evolution of the pension system, based on statistical data evidently proves the efficiently of the soviet pension system. It is highly recommended that the positive aspects of the soviet pension system are taken into consideration when reforming the actual pension system of Russian Federation.

  14. Nuclear plant analyzer development and analysis applications

    International Nuclear Information System (INIS)

    Laats, E.T.

    1984-01-01

    The Nuclear Plant Analyzer (NPA) is being developed as the U.S. Nuclear Regulatory Commission's (NRC's) state of the art safety analysis and engineering tool to address key nuclear plant safety issues. The NPA integrates the NRC's computerized reactor behavior simulation codes such as RELAP5 and TRAC-BWR, both of which are well-developed computer graphics programs, and large repositories of reactor design and experimental data. Utilizing the complex reactor behavior codes as well as the experiment data repositories enables simulation applications of the NPA that are generally not possible with more simplistic, less mechanistic reactor behavior codes. These latter codes are used in training simulators or with other NPA-type software packages and are limited to displaying calculated data only. This paper describes four applications of the NPA in assisting reactor safety analyses. Two analyses evaluated reactor operating procedures, during off-normal operation, for a pressurized water reactor (PWR) and a boiling water reactor (BWR), respectively. The third analysis was performed in support of a reactor safety experiment conducted in the Semiscale facility. The final application demonstrated the usefulness of atmospheric dispersion computer codes for site emergency planning purposes. An overview of the NPA and how it supported these analyses are the topics of this paper

  15. Economic Doctrines and Approaches to Climate Change Policy

    OpenAIRE

    Atkinson, Robert D.; Hackler, Darrene

    2010-01-01

    In climate change, as in all policy issues, economic philosophy has a significant influence on how people view both the problems and the solutions. For the first time, ITIF surveys four dominant schools of economic thought and analyzes how adherents approach policy options for climate change and energy policy. With climate change and major energy legislation stalled, maybe it is time to put aside fixed philosophical notions and take a practical look on ways to address climate change in an eco...

  16. Practical Limitations of Aerosol Separation by a Tandem Differential Mobility Analyzer-Aerosol Particle Mass Analyzer

    OpenAIRE

    Radney, James G.; Zangmeister, Christopher D.

    2016-01-01

    A cavity ring-down spectrometer and condensation particle counter were used to investigate the limitations in the separation of singly and multiply charged aerosol particles by a tandem differential mobility analyzer (DMA) and aerosol particle mass analyzer (APM). The impact of particle polydispersity and morphology was investigated using three materials: nearly-monodisperse polystyrene latex nanospheres (PSL); polydisperse, nearly-spherical ammonium sulfate (AS) and polydisperse lacey fracta...

  17. LATER RETIREMENT? PATTERNS, PREFERENCES, POLICIES

    Directory of Open Access Journals (Sweden)

    Martin Kohli

    2015-07-01

    Full Text Available Pension systems are a major part of the political economy of current societies – much beyond providing old-age income security. The well-known demographics of population aging as well as globalization today challenge their financial viability. Later retirement seems to be a good way to meet these challenges. However, it is not only unpopular but also inequitable in terms of differential longevity. The paper first discusses these problems, with a particular focus on the social stratification of mortality. It then analyzes the preferences towards retirement age at several levels:  in terms of attitudes towards public spending on pensions or towards the state’s responsibility in this matter, of support for pension policy alternatives, and of preferred individual age of retirement. Results show that large majorities across all age groups are in favour of more government spending on pensions. There is a substantial amount of ‘involuntary retirement’, meaning that people would have preferred to work longer than they actually did, as well as a somewhat lower amount of ‘involuntary work’, but the preferred ages are everywhere below 65, and in some countries still below 60. Finally, the paper examines the policies of raising the retirement age adopted during the last two decades. What has especially been lacking in these policies is a consideration of socially differentiated longevity.

  18. Rationality, institutions and environmental policy

    Energy Technology Data Exchange (ETDEWEB)

    Vatn, Arild [Department of Economics and Resource Management, Norwegian University of Life Sciences, Aas (Norway)

    2005-11-01

    This paper is about how institutions determine choices and the importance of this for environmental policy. The model of individual rational choice from neoclassical economics is compared with the model of socially determined behavior. While in the first case, institutions are either exempted from or understood as mere economizing constraints on behavior, the latter perspective views institutions as basic structures necessary also to enable people to act. The paper develops a way to integrate the individualistic model into the wider perspective of social constructivism by viewing it as a special form of such construction. On the basis of this synthesis three issues with relevance for environmental economics are discussed. First, the role of institutional factors in the process of preference formation is emphasized. Next, the role of institutions for the choice of desired states of the environment is analyzed. Finally, the effect of various policy instruments to motivate people to produce these states is discussed. It is concluded that the core policy issue is to determine which institutional frameworks are most reasonable to apply to which kind of problem. Issues, which from the perspective of neoclassical economics are pure technical, become serious value questions if understood from an institutional perspective.

  19. Climate Model Diagnostic Analyzer Web Service System

    Science.gov (United States)

    Lee, S.; Pan, L.; Zhai, C.; Tang, B.; Kubar, T. L.; Li, J.; Zhang, J.; Wang, W.

    2015-12-01

    Both the National Research Council Decadal Survey and the latest Intergovernmental Panel on Climate Change Assessment Report stressed the need for the comprehensive and innovative evaluation of climate models with the synergistic use of global satellite observations in order to improve our weather and climate simulation and prediction capabilities. The abundance of satellite observations for fundamental climate parameters and the availability of coordinated model outputs from CMIP5 for the same parameters offer a great opportunity to understand and diagnose model biases in climate models. In addition, the Obs4MIPs efforts have created several key global observational datasets that are readily usable for model evaluations. However, a model diagnostic evaluation process requires physics-based multi-variable comparisons that typically involve large-volume and heterogeneous datasets, making them both computationally- and data-intensive. In response, we have developed a novel methodology to diagnose model biases in contemporary climate models and implementing the methodology as a web-service based, cloud-enabled, provenance-supported climate-model evaluation system. The evaluation system is named Climate Model Diagnostic Analyzer (CMDA), which is the product of the research and technology development investments of several current and past NASA ROSES programs. The current technologies and infrastructure of CMDA are designed and selected to address several technical challenges that the Earth science modeling and model analysis community faces in evaluating and diagnosing climate models. In particular, we have three key technology components: (1) diagnostic analysis methodology; (2) web-service based, cloud-enabled technology; (3) provenance-supported technology. The diagnostic analysis methodology includes random forest feature importance ranking, conditional probability distribution function, conditional sampling, and time-lagged correlation map. We have implemented the

  20. Novel topological descriptors for analyzing biological networks

    Directory of Open Access Journals (Sweden)

    Varmuza Kurt K

    2010-06-01

    Full Text Available Abstract Background Topological descriptors, other graph measures, and in a broader sense, graph-theoretical methods, have been proven as powerful tools to perform biological network analysis. However, the majority of the developed descriptors and graph-theoretical methods does not have the ability to take vertex- and edge-labels into account, e.g., atom- and bond-types when considering molecular graphs. Indeed, this feature is important to characterize biological networks more meaningfully instead of only considering pure topological information. Results In this paper, we put the emphasis on analyzing a special type of biological networks, namely bio-chemical structures. First, we derive entropic measures to calculate the information content of vertex- and edge-labeled graphs and investigate some useful properties thereof. Second, we apply the mentioned measures combined with other well-known descriptors to supervised machine learning methods for predicting Ames mutagenicity. Moreover, we investigate the influence of our topological descriptors - measures for only unlabeled vs. measures for labeled graphs - on the prediction performance of the underlying graph classification problem. Conclusions Our study demonstrates that the application of entropic measures to molecules representing graphs is useful to characterize such structures meaningfully. For instance, we have found that if one extends the measures for determining the structural information content of unlabeled graphs to labeled graphs, the uniqueness of the resulting indices is higher. Because measures to structurally characterize labeled graphs are clearly underrepresented so far, the further development of such methods might be valuable and fruitful for solving problems within biological network analysis.