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Sample records for pole-aitken basin spa

  1. Basin and Crater Ejecta Contributions to the South Pole-Aitken Basin (SPA) Regolith; Positive Implications for Robotic Surface Samples

    Science.gov (United States)

    Petro, Noah E.; Jolliff, B. L.

    2011-01-01

    The ability of impacts of all sizes to laterally transport ejected material across the lunar surface is well-documented both in lunar samples [1-4] and in remote sensing data [5-7]. The need to quantify the amount of lateral transport has lead to several models to estimate the scale of this effect. Such models have been used to assess the origin of components at the Apollo sites [8-10] or to predict what might be sampled by robotic landers [11-13]. Here we continue to examine the regolith inside the South Pole-Aitken Basin (SPA) and specifically assess the contribution to the SPA regolith by smaller craters within the basin. Specifically we asses the effects of four larger craters within SPA, Bose, Bhabha, Stoney, and Bellinsgauzen all located within the mafic enhancement in the center of SPA (Figure 1). The region around these craters is of interest as it is a possible landing and sample return site for the proposed Moon-Rise mission [14-17]. Additionally, understanding the provenance of components in the SPA regolith is important for interpreting remotely sensed data of the basin interior [18-20].

  2. Surface mineralogy and stratigraphy of the lunar South Pole-Aitken basin from Clementine UV/VIS and NIR data

    NARCIS (Netherlands)

    Borst, A.M.; Foing, B.H.; Davies, G.R.; van Westrenen, W.

    2012-01-01

    The South Pole-Aitken (SPA) basin, located on the lunar far side, is one of the oldest and largest recognised impact structures in the solar system. The basin is a proposed site for future sample return missions and human bases due to the unique geological environment and its potential for

  3. Sample Return Mission to the South Pole Aitken Basin

    Science.gov (United States)

    Duke, M. B.; Clark, B. C.; Gamber, T.; Lucey, P. G.; Ryder, G.; Taylor, G. J.

    1999-01-01

    The South Pole Aitken Basin (SPA) is the largest and oldest observed feature on the Moon. Compositional and topographic data from Galileo, Clementine, and Lunar Prospector have demonstrated that SPA represents a distinctive major lunar terrane, which has not been sampled either by sample return missions (Apollo, Luna) or by lunar meteorites. The floor of SPA is characterized by mafic compositions enriched in Fe, Ti, and Th in comparison to its surroundings. This composition may represent melt rocks from the SPA event, which would be mixtures of the preexisting crust and mantle rocks. However, the Fe content is higher than expected, and the large Apollo basin, within SPA, exposes deeper material with lower iron content. Some of the Fe enrichment may represent mare and cryptomare deposits. No model adequately accounts for all of the characteristics of the SPA and disagreements are fundamental. Is mantle material exposed or contained as fragments in melt rock and breccias? If impact melt is present, did the vast sheet differentiate? Was the initial mantle and crust compositionally different from other regions of the Moon? Was the impact event somehow peculiar, (e.g., a low-velocity impact)? The precise time of formation of the SPA is unknown, being limited only by the initial differentiation of the Moon and the age of the Imbrium event, believed to be 3.9 b.y. The questions raised by the SPA can be addressed only with detailed sample analysis. Analysis of the melt rocks, fragments in breccias, and basalts of SPA can address several highly significant problems for the Moon and the history of the solar system. The time of formation of SPA, based on analysis of melt rocks formed in the event. would put limits on the period of intense bombardment of the Moon, which has been inferred by some to include a "terminal cataclysm." If close to 3.9 Ga, the presumed age of the Imbrium Basin, the SPA date would confirm the lunar cataclysm. This episode, if it occurred, would have

  4. Volume of Impact Melt Generated by the Formation of the South Pole-Aitken Basin

    Science.gov (United States)

    Petro, Noah E.

    2011-01-01

    The South Pole-Aitken Basin (SPA) is the largest, deepest, and oldest identified basin on the Moon and as such contains surfaces that are unique due to their age, composition, and depth of origin in the lunar crust [1-5] (Figure 1). SPA has been a target of intense interest as an area for robotic sample return in order to determine the age of the basin and the composition and origin of its interior [6-8]. In response to this interest there have been several efforts to estimate the likely provenance of regolith material within central SPA [9-12]. These model estimates suggest that, despite the formation of basins and craters following SPA, the regolith within SPA is dominated by locally derived material. An assumption of these models has been that the locally derived material is primarily SPA impact-melt as opposed to local basement material (e.g. unmelted lower crust). However, the definitive identification of SPA derived impact melt on the basin floor, either by remote sensing [5, 13] or via photogeology [2, 14] is extremely difficult due to the number of subsequent impacts and volcanic activity [4].

  5. Moonrise: Sampling the South Pole-Aitken Basin to Address Problems of Solar System Significance

    Science.gov (United States)

    Zeigler, R. A.; Jolliff, B. L.; Korotev, R. L.; Shearer, C. K.

    2016-01-01

    A mission to land in the giant South Pole-Aitken (SPA) Basin on the Moon's southern farside and return a sample to Earth for analysis is a high priority for Solar System Science. Such a sample would be used to determine the age of the SPA impact; the chronology of the basin, including the ages of basins and large impacts within SPA, with implications for early Solar System dynamics and the magmatic history of the Moon; the age and composition of volcanic rocks within SPA; the origin of the thorium signature of SPA with implications for the origin of exposed materials and thermal evolution of the Moon; and possibly the magnetization that forms a strong anomaly especially evident in the northern parts of the SPA basin. It is well known from studies of the Apollo regolith that rock fragments found in the regolith form a representative collection of many different rock types delivered to the site by the impact process (Fig. 1). Such samples are well documented to contain a broad suite of materials that reflect both the local major rock formations, as well as some exotic materials from far distant sources. Within the SPA basin, modeling of the impact ejection process indicates that regolith would be dominated by SPA substrate, formed at the time of the SPA basin-forming impact and for the most part moved around by subsequent impacts. Consistent with GRAIL data, the SPA impact likely formed a vast melt body tens of km thick that took perhaps several million years to cool, but that nonetheless represents barely an instant in geologic time that should be readily apparent through integrated geochronologic studies involving multiple chronometers. It is anticipated that a statistically significant number of age determinations would yield not only the age of SPA but also the age of several prominent nearby basins and large craters within SPA. This chronology would provide a contrast to the Imbrium-dominated chronology of the nearside Apollo samples and an independent test of

  6. Thorium abundances of basalt ponds in South Pole-Aitken basin: Insights into the composition and evolution of the far side lunar mantle

    Science.gov (United States)

    Hagerty, Justin J.; Lawrence, D.J.; Hawke, B.R.

    2011-01-01

    Imbrian-aged basalt ponds, located on the floor of South Pole-Aitken (SPA) basin, are used to provide constraints on the composition and evolution of the far side lunar mantle. We use forward modeling of the Lunar Prospector Gamma Ray Spectrometer thorium data, to suggest that at least five different and distinct portions of the far side lunar mantle contain little or no thorium as of the Imbrian Period. We also use spatial correlations between local thorium enhancements and nonmare material on top of the basalt ponds to support previous assertions that lower crustal materials exposed in SPA basin have elevated thorium abundances, consistent with noritic to gabbronoritic lithologies. We suggest that the lower crust on the far side of the Moon experienced multiple intrusions of thorium-rich basaltic magmas, prior to the formation of SPA basin. The fact that many of the ponds on the lunar far side have elevated titanium abundances indicates that the far side of the Moon experienced extensive fractional crystallization that likely led to the formation of a KREEP-like component. However, because the Imbrian-aged basalts contain no signs of elevated thorium, we propose that the SPA impact event triggered the transport of a KREEP-like component from the lunar far side and concentrated it on the nearside of the Moon. Because of the correlation between basaltic ponds and basins within SPA, we suggest that Imbrian-aged basaltic volcanism on the far side of the Moon was driven by basin-induced decompressional melting.

  7. Lunar Reconnaissance Orbiter Camera Observations Relating to Science and Landing Site Selection in South Pole-Aitken Basin for a Robotic Sample Return Mission

    Science.gov (United States)

    Jolliff, B. L.; Clegg-Watkins, R. N.; Petro, N. E.; Lawrence, S. L.

    2016-01-01

    The Moon's South Pole-Aitken basin (SPA) is a high priority target for Solar System exploration, and sample return from SPA is a specific objective in NASA's New Frontiers program. Samples returned from SPA will improve our understanding of early lunar and Solar System events, mainly by placing firm timing constraints on SPA formation and the post-SPA late-heavy bombardment (LHB). Lunar Reconnaissance Orbiter Camera (LROC) images and topographic data, especially Narrow Angle Camera (NAC) scale (1-3 mpp) morphology and digital terrain model (DTM) data are critical for selecting landing sites and assessing landing hazards. Rock components in regolith at a given landing site should include (1) original SPA impact-melt rocks and breccia (to determine the age of the impact event and what materials were incorporated into the melt); (2) impact-melt rocks and breccia from large craters and basins (other than SPA) that represent the post-SPA LHB interval; (3) volcanic basalts derived from the sub-SPA mantle; and (4) older, "cryptomare" (ancient buried volcanics excavated by impact craters, to determine the volcanic history of SPA basin). All of these rock types are sought for sample return. The ancient SPA-derived impact-melt rocks and later-formed melt rocks are needed to determine chronology, and thus address questions of early Solar System dynamics, lunar history, and effects of giant impacts. Surface compositions from remote sensing are consistent with mixtures of SPA impactite and volcanic materials, and near infrared spectral data distinguish areas with variable volcanic contents vs. excavated SPA substrate. Estimating proportions of these rock types in the regolith requires knowledge of the surface deposits, evaluated via morphology, slopes, and terrain ruggedness. These data allow determination of mare-cryptomare-nonmare deposit interfaces in combination with compositional and mineralogical remote sensing to establish the types and relative proportions of materials

  8. Distribution and Composition of Prominent Low-Ca Pyroxene Exposures in the South Pole-Aitken Basin as Observed by the Moon Mineralogy Mapper (M3)

    Science.gov (United States)

    Klima, R. L.; Petro, N. E.; Isaacson, P.; Sunshine, J. M.; Pieters, C. M.; Head, J. W.

    2010-12-01

    One of the most prominent regional concentrations of noritic material on the Moon is in the South Pole-Aitken (SPA) basin. In addition to the overall noritic signature of much of the basin interior, prominent exposures of spectrally immature noritic materials are associated with large craters in SPA and are readily observed along the crater walls, within central peaks or in fresh craters on the floors of these larger craters. Because the mafic mineralogy of norite is overwhelmingly dominated by orthopyroxene, it is possible to use spectral properties of norites to estimate the Mg’ (Mg’=Mg/(Mg+Fe) of the pyroxenes in the rocks. We here use global-mode data from the Moon Mineralogy Mapper to characterize the composition of norites throughout SPA. We identify broad compositional trends in SPA and assess whether they are spatially significant, classifying each site as dominated by high- (Mg’>75), medium- (Mg’50-75), or low- (Mg’sheet. The 480 km diameter, pre-Nectarian Apollo basin is located on the edge of SPA, and sits above some of the thinnest crust on the Moon [Ishihara et al., 2009; Petro et al., 2010]. The most noritic portions of Dryden crater are exposed along the eastern wall of Dryden crater, closest to the inner ring of Apollo, and Chaffee S also lies near the inner ring [Klima et al., 2010]. There are several hypotheses being considered to explain the more magnesian character of these low-Ca pyroxenes. Given the thin nature of the crust at Apollo, and the positioning of the high-Mg detections on the inner ring of the basin, Apollo may have excavated deeper primary crustal (or mantle) material than is exposed elsewhere in SPA. Alternatively. If SPA is covered by a differentiated melt sheet, the Apollo basin may have excavated material from a more magnesian cumulate pile at its base. Finally, it is possible that Apollo impacted a local Mg-rich intrusion, emplaced after the SPA-forming impact.

  9. Magnetization in the South Pole-Aitken basin: Implications for the lunar dynamo and true polar wander

    Science.gov (United States)

    2016-10-14

    lunar dynamo may have been variable in direction. Published by Elsevier Inc. 1 o a M s u t o F R P b w 1 r l h c i n...i n i t a n H ttp://dx.doi.org/10.1016/j.icarus.2016.09.038 019-1035/ Published by Elsevier Inc. rium and Serenitatis basins has...Bethell a , c a Department of Earth & Planetary Sciences , University of California Santa Cruz, 1156 High Street, Santa Cruz, CA, 95064, USA b Red Sky

  10. South Pole-Aitken Sample Return Mission: Collecting Mare Basalts from the Far Side of the Moon

    Science.gov (United States)

    Gillis, J. J.; Jolliff, B. L.; Lucey, P. G.

    2003-01-01

    We consider the probability that a sample mission to a site within the South Pole-Aitken Basin (SPA) would return basaltic material. A sample mission to the SPA would be the first opportunity to sample basalts from the far side of the Moon. The near side basalts are more abundant in terms of volume and area than their far-side counterparts (16:1), and the basalt deposits within SPA represent approx. 28% of the total basalt surface area on the far side. Sampling far-side basalts is of particular importance because as partial melts of the mantle, they could have derived from a mantle that is mineralogically and chemically different than determined for the nearside, as would be expected if the magma ocean solidified earlier on the far side. For example, evidence to support the existence of high-Th basalts like those that appear to be common on the nearside in the Procellarum KREEP Terrane has been found. Although SPA is the deepest basin on the Moon, it is not extensively filled with mare basalt, as might be expected if similar amounts of partial melting occurred in the mantle below SPA as for basins on the near side. These observations may mean that mantle beneath the far-side crust is lower in Th and other heat producing elements than the nearside. One proposed location for a sample-return landing site is 60 S, 160 W. This site was suggested to maximize the science return with respect to sampling crustal material and SPA impact melt, however, basaltic samples would undoubtedly occur there. On the basis of Apollo samples, we should expect that basaltic materials would be found in the vicinity of any landing site within SPA, even if located away from mare deposits. For example, the Apollo 16 mission landed in an ancient highlands region 250-300 km away from the nearest mare-highlands boundary yet it still contains a small component of basaltic samples (20 lithic fragments ranging is size from <1 to .01 cm). A soil sample from the floor of SPA will likely contain an

  11. Pulling Marbles from a Bag: Deducing the Regional Impact History of the SPA Basin from Impact-Melt Rocks

    Science.gov (United States)

    Cohen, Barbara A.; Coker, Robert F.

    2010-01-01

    The South Pole Aitken (SPA) basin is the stratigraphically oldest identifiable lunar basin and is therefore one of the most important targets for absolute age-dating to help understand whether ancient lunar bombardment history smoothly declined or was punctuated by a cataclysm. A feasible near-term approach to this problem is to robotically collect a sample from near the center of the basin, where vertical and lateral mixing provided by post-basin impacts ensures that such a sample will be composed of small rock fragments from SPA itself, from local impact craters, and from faraway giant basins. The range of ages, intermediate spikes in the age distribution, and the oldest ages are all part of the definition of the absolute age and impact history recorded within the SPA basin.

  12. Pulling Marbles from a Bag: Deducing the Regional Impact History of the SPA Basin from Impact Melt Rocks

    Science.gov (United States)

    Cohen, Barbara A.; Coker, R. F.

    2009-01-01

    The South Pole-Aitken (SPA) basin is an important target for absolute age-dating. Vertical and lateral impact mixing ensures that regolith within SPA will contain rock fragments from SPA itself, local impact craters, and faraway giant basins. About 20% of the regolith at any given site is foreign [1, 2], but much of this material will be cold ejecta, not impact melt. We calculated the fraction of contributed impact melt using scaling laws to estimate the amount and provenance of impact melt, demonstrating that SPA melt is the dominant impact melt rock (>70%) likely to be present. We also constructed a statistical model to illustrate how many randomly-selected impact-melt fragments would need to be dated, and with what accuracy, to confidently reproduce the impact history of a site. A detailed impact history becomes recognizable after a few hundred to a thousand randomly-selected marbles, however, it will be useful to have more information (e.g. compositional, mineralogical, remote sensing) to group fragments. These exercises show that SPA melt has a high probability of being present in a scoop sample and that dating of a few hundred to a thousand impact-melt fragments will yield the impact history of the SPA basin.

  13. Ground Water SPA

    Data.gov (United States)

    Vermont Center for Geographic Information — Groundwater SPA. This GIS layer consists of the geographic location of the Source Protection Areas for active and inactive Public Community and Non-Transient...

  14. Spa therapy in dermatology

    Directory of Open Access Journals (Sweden)

    Najeeba Riyaz

    2011-01-01

    Full Text Available Spa therapy constitutes the use of mineral springs and thermal mud to soothe and heal various ailments. Like the mineral springs, seas and oceans are also important centers for spa therapy of which the most important is Dead Sea (DS. DS has been famous for thousands of years for its miraculous curative and cosmetic properties. Intensive research is going on using DS minerals in a wide range of dermatological conditions especially psoriasis, atopic dermatitis, vitiligo and other eczemas and several papers have been published in various international and pharmacological journals.

  15. Software Process Assessment (SPA)

    Science.gov (United States)

    Rosenberg, Linda H.; Sheppard, Sylvia B.; Butler, Scott A.

    1994-01-01

    NASA's environment mirrors the changes taking place in the nation at large, i.e. workers are being asked to do more work with fewer resources. For software developers at NASA's Goddard Space Flight Center (GSFC), the effects of this change are that we must continue to produce quality code that is maintainable and reusable, but we must learn to produce it more efficiently and less expensively. To accomplish this goal, the Data Systems Technology Division (DSTD) at GSFC is trying a variety of both proven and state-of-the-art techniques for software development (e.g., object-oriented design, prototyping, designing for reuse, etc.). In order to evaluate the effectiveness of these techniques, the Software Process Assessment (SPA) program was initiated. SPA was begun under the assumption that the effects of different software development processes, techniques, and tools, on the resulting product must be evaluated in an objective manner in order to assess any benefits that may have accrued. SPA involves the collection and analysis of software product and process data. These data include metrics such as effort, code changes, size, complexity, and code readability. This paper describes the SPA data collection and analysis methodology and presents examples of benefits realized thus far by DSTD's software developers and managers.

  16. Strand SPA & Konverentsikeskus

    Index Scriptorium Estoniae

    2008-01-01

    Strand SPA & Konverentsikeskus on Pärnu suurim äri- ja konverentsiklientidele suunatud hotell, mis klientide seas on hinnatud just selle kompleksuse tõttu, kuna kõik, mida külaline vajab ja soovib, on olemas ühe katuse all

  17. Spa, Spa Tourism and Wellness Tourism in the Czech Republic

    Directory of Open Access Journals (Sweden)

    Vystoupil Jiří

    2017-06-01

    Full Text Available The aim of this paper is to compare and assess the position of the spa and wellness sector in the structure of tourism in the Czech Republic. In this context, the article deals with the brief history of the Czech spa tourism and the development of spa tourism in the spa resorts, including the focus of specialized literature review. The methodological part consists of an explanation of the existing statistical information about the spa sector. The main part of the paper deals with the geographic analysis of current spa centres (the capacity of spa and total collective accommodation facilities, the number of spa patients and guests, guest attendance and their geographical structure. The assessment also includes the determination of the importance of the spa for overall spa tourism. Furthermore, the paper also deals with the development and localization of the selected forms of wellness tourism. As a pilot example, aquaparks built especially in the last 20 years in the Czech Republic were chosen.

  18. Hubungan antara Demografi Konsumen dengan Kepuasan terhadap Layanan Paket Perawatan Spa di GY Spa Jakartal

    Directory of Open Access Journals (Sweden)

    Hera Oktadiana

    2010-11-01

    Full Text Available Spa industry has been growing quite fast in many parts of the world, including Indonesia. The prospect of spa business is still very positive and wide open. There are many varieties of spas offered, such as day spas, hotel-based spas, resort spas and destination spas. Regardless of the type of spa, most spa operators provide massage and nutrition related services. GY Spa, one of the best spa operators in Jakarta offers several spa packages which include body massage, body treatment, body scrub, face massage and aromatheraphy. This research aims to find the correlation between the demographic segmentation and the consumer satisfaction towards the spa packages in GY Spa. Based on the research, it is found that education, occupation and nationality have no correlation toward the consumer satisfaction, while age and gender shown to have correlation. Female and the younger customers are more satisfied with the spa packages offered by GY Spa

  19. Lunar Impact Basins: Stratigraphy, Sequence and Ages from Superposed Impact Crater Populations Measured from Lunar Orbiter Laser Altimeter (LOLA) Data

    Science.gov (United States)

    Fassett, C. I.; Head, J. W.; Kadish, S. J.; Mazarico, E.; Neumann, G. A.; Smith, D. E.; Zuber, M. T.

    2012-01-01

    Impact basin formation is a fundamental process in the evolution of the Moon and records the history of impactors in the early solar system. In order to assess the stratigraphy, sequence, and ages of impact basins and the impactor population as a function of time, we have used topography from the Lunar Orbiter Laser Altimeter (LOLA) on the Lunar Reconnaissance Orbiter (LRO) to measure the superposed impact crater size-frequency distributions for 30 lunar basins (D = 300 km). These data generally support the widely used Wilhelms sequence of lunar basins, although we find significantly higher densities of superposed craters on many lunar basins than derived by Wilhelms (50% higher densities). Our data also provide new insight into the timing of the transition between distinct crater populations characteristic of ancient and young lunar terrains. The transition from a lunar impact flux dominated by Population 1 to Population 2 occurred before the mid-Nectarian. This is before the end of the period of rapid cratering, and potentially before the end of the hypothesized Late Heavy Bombardment. LOLA-derived crater densities also suggest that many Pre-Nectarian basins, such as South Pole-Aitken, have been cratered to saturation equilibrium. Finally, both crater counts and stratigraphic observations based on LOLA data are applicable to specific basin stratigraphic problems of interest; for example, using these data, we suggest that Serenitatis is older than Nectaris, and Humboldtianum is younger than Crisium. Sample return missions to specific basins can anchor these measurements to a Pre-Imbrian absolute chronology.

  20. Measurements of radon concentrations in Spa waters in Amasya, Turkey

    Energy Technology Data Exchange (ETDEWEB)

    Yigitoglu, I., E-mail: ibrahim.yigitoglu@gop.edu.tr; Ucar, B. [Faculty of Science and Arts, Department of Physics, Gaziosmanpasa University, Tokat (Turkey); Oner, F. [Faculty of Education, Department of Physics, Amasya University, Amasya Turkey (Turkey); Yalim, H. A. [Faculty of Science and Arts, Department of Physics, Afyon Kocatepe University, Afyonkarahisar Turkey (Turkey)

    2016-04-18

    The aim of this study is to determine the radon concentrations in thermal waters in the Amasya basin in Turkey and to explore the relationship between radon anomalies and active geological faults. The radon concentration measurements were performed in four thermal Spas around Amasya basin. The water samples were collected from tap waters in thermal water sources. The obtained radon concentrations ranged from 0.15 ± 0.12 to 0.71 ± 0.32 BqL{sup −1} for Spa waters. The relationship between the radon concentration anomalies and earthquakes that occurred in the sampling period are discussed.

  1. Aplicació Microsoft .Net : Hotel Spa

    OpenAIRE

    Marquès Palmer, Jordi

    2010-01-01

    Desenvolupament d'una aplicació amb Microsoft .NET, WCF, WPF, Linq2SQL, d'un Hotel Spa. Desarrollo de una aplicación con Microsoft .NET, WCF, WPF, Linq2SQL, de un Hotel Spa. Application development using Microsoft .NET, WCF, WPF, Linq2SQL, for a Spa Hotel.

  2. Thermal spa Kezovica, opportunities for tourism development

    OpenAIRE

    Taskov, Nako; Metodijeski, Dejan

    2012-01-01

    Subject of this article is the spa Kezhovica and opportunities for its tourism development. First part of the paper provides general information related to the spa, its location, the historical development and current condition and capacity. The second part natural and anthropogenic resources for tourism development are processed and presented. The third part is devoted to the features of water and the medical treatment abilities of the spa. The last section includes conclusions and recommend...

  3. [Nonnius and the Spa cure].

    Science.gov (United States)

    Lecomte, J; Lemli, J; Marganne, M H; Melard, M

    1996-01-01

    The 12th of July 1635, Jan van Beverwyck wrote a letter from Dordrecht to his esteemed friend Luis Nunez, in Antwerp. He asked him for indications about the cure of kidney stones of which he was suffering. He had just passed two calculi very painfully. Nunez answered on July 31. His letter summarized his own experience with this disease. In such cases, temperate diuretics and emollients are well indicated: ingestion of light decoctions of Malva and Viola, Caerefolium and Parieteria as well as Marshmallow syrup. No purge and no 'chemicals'. However, the best remedy was drinking Spa water. Usually the best way to absorb it is to come to the springs, in the Ardennes, part of the independent Principality of Liège. However, considering the horrors of the war (the Thirty Years War) endangering the country, van Beverwyck would be wise to drink imported water during 40 or 50 days, while staying home quietly, in Dordrecht. The letter points out the importance of provoked diuresis in the treatment of kidney stones. On the other hand the letter is an illustration of the continuing contacts between the United Provinces and the Spanish territories and of the commercial traffic between Antwerp, Dordrecht and Spa. The exported water was bottled from many 'pouhons'. It was acid, ferruginous, sulfurous and saturated with carbon dioxide; no pathogen germs, at least at the spring. Nunez quoted the large number of his patients cured with Spa water in Antwerp. This is an illustration of its commercial expansion even during this critical period.

  4. Cultural differences in spa tourism and the expectations of Finnish spa goers

    OpenAIRE

    Saar, Maarja

    2010-01-01

    Spa Tourism is one of the many branches of the fast growing and continuously developing Health and Wellness Tourism. The aim of the present bachelor’s thesis was to explore the consumption habits and the customers’ wishes regarding the Finnish Spa Tourism through a customer survey and to discuss the differences in spa tourism in different regions. The wishes for a future spa experience formed a part of the customer survey and future insights of the industry in general are discussed in the wor...

  5. Radioactivity of spa waters in Serbia

    International Nuclear Information System (INIS)

    Tanaskovic, I.; Eremic Savkovic, M.; Javorina, Lj.

    2011-01-01

    In this paper, the measurement results of: total alpha and beta activity, as well as specific activity of 226 Ra, 228 Ra, 40 K and conductivity of spa waters of Serbia, are presented. Spa water samples were taken in the fields of different types of geological environment. The maximum values of specific activity of 226 Ra, 228 Ra and 40 K were 0.53 Bq / l, [sr

  6. Incorporating a medical spa into a physician-run practice.

    Science.gov (United States)

    Katz, Bruce; McBean, Jason

    2008-07-01

    The age-old spa concept is no less valuable today than it was during the time of Julius Caesar. Over the centuries, there have been many iterations of the concept of the spa. The most recent is the medical spa, which has become the fastest-growing segment of the spa industry. Many physicians including dermatologists wish to incorporate a medical spa into their practices. This article discusses the key elements that should be considered to make this venture successful.

  7. PREREQUISITES FOR DEVELOPMENT OF SPA TOURISM IN BULGARIA

    OpenAIRE

    Manuela Vucheva

    2016-01-01

    The demand for spa tourism in Bulgaria has increased 3 times in the last five years. Worldwide demand for spa for travel increased 2 times since 2004. Indications show that spa tourism is developing in a positive direction, both in Bulgaria and abroad. In Bulgaria there are 25 spa destinations where there are hydromineral fields and complexes for accommodation and rest. The paper provides key conclusions in relation to the development of spa tourism in Bulgaria and recommendations for improve...

  8. Health tourism in a Czech health spa.

    Science.gov (United States)

    Speier, Amy R

    2011-04-01

    This paper is about the changing shape of health tourism in a Czech spa town. The research focuses on balneotherapy as a traditional Czech healing technique, which involves complex drinking and bathing therapies, as it is increasingly being incorporated into the development of a Czech health tourism industry. Today, the health tourism industry in Mariánske Lázne is attempting to 'harmoniously' combine three elements--balneology, travel and business activities. One detects subtle shifts and consequent incongruities as doctors struggle for control over the medical portion of spa hotels. At the same time, marketing groups are creating new packages for a general clientele, and the implementation of these new packages de-medicalizes balneotherapy. Related to the issue of the doctor's authority in the spa, the changes occurring with the privatization of tourism entails the entrance of 'tourists' to Mariánske Lázne who are not necessarily seeking spa treatment but who are still staying at spa hotels. There is a general consensus among spa doctors and employees that balneotherapy has become commodified. Thus, while balneotherapy remains a traditional form of therapy, the commercial context in which it exists has created a new form of health tourism.

  9. Delineating the major KREEP-bearing terranes on the moon with global measurements of absolute thorium abundances

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence, D.J.; Feldman, W.C.; Barraclough, B.L.; Elphic, R.C.; Prettyman, T.H. [Los Alamos National Lab., NM (United States); Binder, A.B. [Lunar Research Inst., Gilroy, CA (United States); Maurice, S. [Observatoire Midi-Pyrenees, Toulouse (France); Miller, M.C. [Lawrence Livermore National Lab., CA (United States)

    1999-03-01

    The Lunar Prospector (LP) Gamma-Ray Spectrometer (GRS) has been used to map the global composition of thorium on the lunar surface. Previous LP results of relative thorium abundances demonstrated that thorium is highly concentrated in and around the nearside western maria and less so in the South Pole Aitken (SPA) basin. Using new detector modeling results and a larger data set, the authors present here a global map of absolute thorium abundances on a 2{degree} by 2{degree} equal-area pixel scale. Because thorium is a tracer of KREEP-rich material, these data provide fundamental information regarding the locations and importance of terranes that are rich in KREEP bearing materials.

  10. Radon in the spa of Bizovac

    International Nuclear Information System (INIS)

    Planinic, J.; Faj, Z.; Suveljak, B.; Radolic, V.

    1996-01-01

    The radon concentration in the air and water of the Bizovac spa was measured by the Radhome silicon detector and the average values were obtained as 70 Bq/m 3 in the indoor pool, 40 Bq/m 3 in the hotel room, 135 Bq/m 3 in the closed therapeutic bathroom, but the geothermal water had a Rn concentration of 25.3 kBq/m 3 and the potable one 2.7 kBq/m 3 . The Rn transfer factor (f) from water to air in the indoor pool and therapeutic bathroom was 10 and 40 times higher than for normal dwellings (f n =10 -4 ), respectively. The effective equivalent dose of inhaled radon for permanent personnel under the worst conditions in the spa was 5.4 mSv/y, but visitors spending two weeks in the spa could receive the dose of 77 μSv. (author). 6 refs., 1 fig

  11. Spa culture and tradition in Republic of Macedonia

    OpenAIRE

    Angelkova, Tanja; Metodijeski, Dejan

    2017-01-01

    The main subject of this presentationare spa culture andtradition in Republic of Macedonia. In the presentation,the author will define spa tourism and spa products, also the spas in Republic of Macedonia will be classified by the the quality of natural and anthropogenic resources surrounding them, historical development, contemporary situation etc. The presentation will provide statistical data and define the profile of spa tourist in Republic of Macedonia. For the presentation, a research an...

  12. The SPA Tourism Perception in Romania

    Directory of Open Access Journals (Sweden)

    Ionica SOARE

    2014-11-01

    Full Text Available Tourism or geriatric-medical and wellness tourism are market segments that lately have registered significant increases. The need to define, organize, and promote these sectors. This item is intended to synthesize developments and challenges market growth wellness and medical tourism. For the industry spa these developments may represent an opportunity to take full advantage of wellness and medical tourism.

  13. Radon measurement in the spa of Bizovac

    International Nuclear Information System (INIS)

    Faj, Z.; Radolic, V.; Suveljak, B.; Planinic, J.

    1996-01-01

    The spa of Bizovac is located 20 km on the west of Osijek in east Croatia. Radon concentrations in the air and water of the Bizovac spa were measured by the Radhome silicon detector and the average values were obtained as 70 Bq/m 3 in the indoor pool, 40 Bq/m 3 in the hotel room and 135 Bq/m 3 in the closed therapeutic bathroom. A special experiment was performed in a closed therapeutic bathroom by three bathtubes filled up with geothermal water as well as normal (potable) one from water-supply. Using measured radon concentrations in air by Radhome detector under the mentioned conditions in the closed bathroom, radon concentrations were assessed for the geothermal water as 25.3 Bq/m 3 and 2.7 Bq/m 3 for potable water. Radon in potable water, measured by the sampling glass ampoule and scintillation cell, had the concentration of 3.5 Bq/m 3 . The radon transfer factor from water to air in the indoor pool and therapeutic bathroom was 10 and 40 times higher than for normal dwelling factor (10 -4 ), respectively. The effective dose equivalent of inhaled radon for permanent personnel under the worst conditions in the spa (closed therapeutic bathroom) was 5.4 mSv/y, but visitors spending two weeks in the Bizovac spa could receive the dose of 77 μSv. (author)

  14. The SPA Tourism Perception in Romania

    OpenAIRE

    Ionica SOARE; Gheorghe Adrian ZUGRAVU

    2014-01-01

    Tourism or geriatric-medical and wellness tourism are market segments that lately have registered significant increases. The need to define, organize, and promote these sectors. This item is intended to synthesize developments and challenges market growth wellness and medical tourism. For the industry spa these developments may represent an opportunity to take full advantage of wellness and medical tourism.

  15. PREREQUISITES FOR DEVELOPMENT OF SPA TOURISM IN BULGARIA

    Directory of Open Access Journals (Sweden)

    Manuela Vucheva

    2016-12-01

    Full Text Available The demand for spa tourism in Bulgaria has increased 3 times in the last five years. Worldwide demand for spa for travel increased 2 times since 2004. Indications show that spa tourism is developing in a positive direction, both in Bulgaria and abroad. In Bulgaria there are 25 spa destinations where there are hydromineral fields and complexes for accommodation and rest. The paper provides key conclusions in relation to the development of spa tourism in Bulgaria and recommendations for improvements in marketing and advertising and combination with other types of tourism.

  16. SPA: a probabilistic algorithm for spliced alignment.

    Directory of Open Access Journals (Sweden)

    2006-04-01

    Full Text Available Recent large-scale cDNA sequencing efforts show that elaborate patterns of splice variation are responsible for much of the proteome diversity in higher eukaryotes. To obtain an accurate account of the repertoire of splice variants, and to gain insight into the mechanisms of alternative splicing, it is essential that cDNAs are very accurately mapped to their respective genomes. Currently available algorithms for cDNA-to-genome alignment do not reach the necessary level of accuracy because they use ad hoc scoring models that cannot correctly trade off the likelihoods of various sequencing errors against the probabilities of different gene structures. Here we develop a Bayesian probabilistic approach to cDNA-to-genome alignment. Gene structures are assigned prior probabilities based on the lengths of their introns and exons, and based on the sequences at their splice boundaries. A likelihood model for sequencing errors takes into account the rates at which misincorporation, as well as insertions and deletions of different lengths, occurs during sequencing. The parameters of both the prior and likelihood model can be automatically estimated from a set of cDNAs, thus enabling our method to adapt itself to different organisms and experimental procedures. We implemented our method in a fast cDNA-to-genome alignment program, SPA, and applied it to the FANTOM3 dataset of over 100,000 full-length mouse cDNAs and a dataset of over 20,000 full-length human cDNAs. Comparison with the results of four other mapping programs shows that SPA produces alignments of significantly higher quality. In particular, the quality of the SPA alignments near splice boundaries and SPA's mapping of the 5' and 3' ends of the cDNAs are highly improved, allowing for more accurate identification of transcript starts and ends, and accurate identification of subtle splice variations. Finally, our splice boundary analysis on the human dataset suggests the existence of a novel non

  17. Supersymmetry Parameter Analysis : SPA Convention and Project

    CERN Document Server

    Aguilar-Saavedra, J A; Allanach, Benjamin C; Arnowitt, R; Baer, H A; Bagger, J A; Balázs, C; Barger, V; Barnett, M; Bartl, Alfred; Battaglia, M; Bechtle, P; Belyaev, A; Berger, E L; Blair, G; Boos, E; Bélanger, G; Carena, M S; Choi, S Y; Deppisch, F; Desch, Klaus; Djouadi, A; Dutta, B; Dutta, S; Díaz, M A; Eberl, H; Ellis, Jonathan Richard; Erler, Jens; Fraas, H; Freitas, A; Fritzsche, T; Godbole, Rohini M; Gounaris, George J; Guasch, J; Gunion, J F; Haba, N; Haber, Howard E; Hagiwara, K; Han, L; Han, T; He, H J; Heinemeyer, S; Hesselbach, S; Hidaka, K; Hinchliffe, Ian; Hirsch, M; Hohenwarter-Sodek, K; Hollik, W; Hou, W S; Hurth, Tobias; Jack, I; Jiang, Y; Jones, D R T; Kalinowski, Jan; Kamon, T; Kane, G; Kang, S K; Kernreiter, T; Kilian, W; Kim, C S; King, S F; Kittel, O; Klasen, M; Kneur, J L; Kovarik, K; Kraml, Sabine; Krämer, M; Lafaye, R; Langacker, P; Logan, H E; Ma, W G; Majerotto, Walter; Martyn, H U; Matchev, K; Miller, D J; Mondragon, M; Moortgat-Pick, G; Moretti, S; Mori, T; Moultaka, G; Muanza, S; Mukhopadhyaya, B; Mühlleitner, M M; Nauenberg, U; Nojiri, M M; Nomura, D; Nowak, H; Okada, N; Olive, Keith A; Oller, W; Peskin, M; Plehn, T; Polesello, G; Porod, Werner; Quevedo, Fernando; Rainwater, D L; Reuter, J; Richardson, P; Rolbiecki, K; de Roeck, A; Weber, Ch.

    2006-01-01

    High-precision analyses of supersymmetry parameters aim at reconstructing the fundamental supersymmetric theory and its breaking mechanism. A well defined theoretical framework is needed when higher-order corrections are included. We propose such a scheme, Supersymmetry Parameter Analysis SPA, based on a consistent set of conventions and input parameters. A repository for computer programs is provided which connect parameters in different schemes and relate the Lagrangian parameters to physical observables at LHC and high energy e+e- linear collider experiments, i.e., masses, mixings, decay widths and production cross sections for supersymmetric particles. In addition, programs for calculating high-precision low energy observables, the density of cold dark matter (CDM) in the universe as well as the cross sections for CDM search experiments are included. The SPA scheme still requires extended efforts on both the theoretical and experimental side before data can be evaluated in the future at the level of the d...

  18. "Roman Baths" in Contemporary Spa Tourism

    OpenAIRE

    Vesna Merc

    2005-01-01

    The commercialisation of images and symbols from antiquity, so characteristic of Slovenia since its independence, has been reflected over the last decade in spa tourism as well. Since the great crises in the sixties, and especially since the eighties, fifteen Slovene natural health resorts have concentrated on developing wellness and activities programs. This change in orientation has been accompanied by renovations, an expansion of the water surfaces and capacities, and new wellbeing, wellne...

  19. HAKONE – THE SPA CENTER OF JAPAN

    Directory of Open Access Journals (Sweden)

    Pavlina Georgieva

    2016-06-01

    Full Text Available The article discusses the combination of ancient traditions of Japan and modern methods used in the Hyatt Regency Hakone Resort and SPA. It presents interesting approaches in attracting tourists and makes parallels how such practices can be applied in Bulgaria. The main conclusions emphasize on the main competitive advantages that should be used to promote destinations for integrated development of various types of tourism.

  20. Supersymmetry Parameter Analysis: SPA Convention and Project

    Energy Technology Data Exchange (ETDEWEB)

    Hinchliffe, I.; et al.

    2005-05-05

    High-precision analyses of supersymmetry parameters aim atreconstructing the fundamental supersymmetric theory and its breakingmechanism. A well defined theoretical framework is needed whenhigher-order corrections are included. We propose such a scheme,Supersymmetry Parameter Analysis SPA, based on a consistent set ofconventions and input parameters. A repository for computer programs isprovided which connect parameters in different schemes and relate theLagrangian parameters to physical observables at LHC and high energy e+e-linear collider experiments, i.e., masses, mixings, decay widths andproduction cross sections for supersymmetric particles. In addition,programs for calculating high-precision low energy observables, thedensity of cold dark matter (CDM) in the universe as well as the crosssections for CDM search experiments are included. The SPA scheme stillrequires extended efforts on both the theoretical and experimental sidebefore data can be evaluated in the future at the level of the desiredprecision. We take here an initial step of testing the SPA scheme byapplying the techniques involved to a specific supersymmetry referencepoint.

  1. State, planning and design of Jodna spa in Novi Sad

    Directory of Open Access Journals (Sweden)

    Garača Vuk

    2012-01-01

    Full Text Available The paper treats the area of Jodna spa in Novi Sad, which largely coincides with Futoški park, making with it the indissoluble unity. The main problem in the functioning of the Jodna psa is the fact that in legal sense Jodna spa does not exists, and in spatial sense there are still all of its content. The case of the paper is Jodna spa area, which includes the Special Hospital for Rheumatic Diseases, Hotel 'Park', Sports Center 'Sajmište' and Futoški park, which integrate them. The question of the Jodna spa planning, as well as the modern city recreation, spa and tourist center, is the goal of this paper. For this purpose it was necessary to show the historical background of the development of Jodna spa, to make the assessment of the state, critically analyze spatial plans which treat it and provide concrete suggestions for its design and equipping.

  2. Present state and perspectives of spa tourism development in Serbia

    Directory of Open Access Journals (Sweden)

    Jovičić Dobrica

    2008-01-01

    Full Text Available Apart from very contaminated spatial areas, there are places with attractive and non-polluted environment, that are suitable for tourism and recreation. Such places are spa resorts, characterized by numerous and various natural elements having significant health and recreative functions (thermo-mineral springs, rare gases, favorable climatic conditions, rich vegetation, etc., which attract attention of ample tourist demand. Serbia is welknown as a 'country of spa resorts', because of a great number of thermo-mineral springs, long tradition and their significance for tourism economy. Official statistical service keeps records of tourist flows only at 30 spa resorts (approximately, having participation at 95% of the total tourist trade in Serbia's spas. The topic of this paper is devoted to estimation of the present state and perspectives of spa tourism in Serbia. Special attention is focused on: analysis of resources for spa tourism, discussion of key factors for tourist valorization of Serbia's spas, investigation of structural features of spa tourism, comparison of Serbia's experiences in domain of spa tourism with contemporary trends in certain spa resorts in other European countries, and, finally, defining the most important tasks for spa tourism improvement.

  3. SWOT ANALYSIS OF SPA TOURISM IN BULGARIA

    Directory of Open Access Journals (Sweden)

    Aleksandar Davchev

    2016-06-01

    Full Text Available Our time is marked by the increasingly dynamic changing environment. The new conditions in which we operate are characterized by increasing complexity and labor activities that require more responsible behavior. The rising levels of stress and the increasing lack of free time for relaxation and recreation require a new look at the possibilities for the prevention of personal health. The plane of the consumer society in which we live is increasingly shifted by aspiration and vision of an environmentally friendly lifestyle. The focus here is the implementation of a multilevel wellness concept that changes qualitatively the status quo and seeks for ways to harmonize the body with the nature. One of the options is the practice of SPA tourism in whose genesis is the multilayered beneficial impact of a series of procedures and actions. This new alternative through its economic dimensions is an attractive business niche which over time becomes an industry. The current state of the SPA tourism in Bulgaria is controversial despite existing achievements and introduced best practices. Traditions in this direction and the presence of favorable basis for its approval, however, are not sufficient to achieve stability and an upward trend in development. There are existing a number of weaknesses and negative aspects that create frustration in users, which is a real threat to its future. The proposed SWOT-analysis as part of a comprehensive and multilateral study of the state of SPA tourism in Bulgaria reveals some of the existing problems. There have been some suggestions to minimize the impact of weaknesses and eliminate the errors found in leading business organizations managing processes. A detailed analysis and evaluation of the formulated conclusions is ahead, as well as concluding on ideas to improve the state of the sector – a subject of a further investigation by the author.

  4. Misi Baby Spa - Un Mundo para Bebes

    OpenAIRE

    2012-01-01

    Misi Baby Spa es un lugar privilegiado concebido y diseñado especialmente para mamás, papás y bebés. Busca fortalecer el vínculo afectivo entre el núcleo familiar con herramientas como la lúdica, la música y el agua. Aliado con grandes marcas representativas del sector y encadenado a la marca Misi brindará un gran respaldo y garantía de servicio a sus clientes. Hombres y mujeres de clase media alta y alta interesados en el cuidado de y desarrollo de sus hijos, obtendrán en ...

  5. Lunar Meteorites Sayh Al Uhaymir 449 and Dhofar 925, 960, and 961: Windows into South Pole

    Science.gov (United States)

    Ziegler, Ryan A.; Jolliff, B. L.; Korotev, R. L.

    2013-01-01

    In 2003, three lunar meteorites were collected in close proximity to each other in the Dhofar region of Oman: Dhofar 925 (49 g), Dhofar 960 (35 g), and Dhofar 961 (22 g). In 2006, lunar meteorite Sayh al Uhaymir (SaU) 449 (16.5 g) was found about 100 km to the NE. Despite significant differences in the bulk composition of Dhofar 961 relative to Dhofar 925/960 and SaU 449 (which are identical to each other), these four meteorites are postulated to be paired based on their find locations, bulk composition, and detailed petrographic analysis. Hereafter, they will collectively be referred to as the Dhofar 961 clan. Comparison of meteorite and component bulk compositions to Lunar Prospector 5-degree gamma-ray data suggest the most likely provenance of this meteorite group is within the South Pole-Aitken Basin. As the oldest, largest, and deepest recognizable basin on the Moon, the composition of the material within the SPA basin is of particular importance to lunar science. Here we review and expand upon the geochemistry and petrography of the Dhofar 961 clan and assess the likelihood that these meteorites come from within the SPA basin based on their bulk compositions and the compositions and characteristics of the major lithologic components found within the breccia.

  6. Modified Decoding Algorithm of LLR-SPA

    Directory of Open Access Journals (Sweden)

    Zhongxun Wang

    2014-09-01

    Full Text Available In wireless sensor networks, the energy consumption is mainly occurred in the stage of information transmission. The Low Density Parity Check code can make full use of the channel information to save energy. Because of the widely used decoding algorithm of the Low Density Parity Check code, this paper proposes a new decoding algorithm which is based on the LLR-SPA (Sum-Product Algorithm in Log-Likelihood-domain to improve the accuracy of the decoding algorithm. In the modified algorithm, a piecewise linear function is used to approximate the complicated Jacobi correction term in LLR-SPA decoding algorithm. Construct the tangent by the tangency point to the function of Jacobi correction term, which is based on the first order Taylor Series. In this way, the proposed piecewise linear approximation offers almost a perfect match to the function of Jacobi correction term. Meanwhile, the proposed piecewise linear approximation could avoid the operation of logarithmic which is more suitable for practical application. The simulation results show that the proposed algorithm could improve the decoding accuracy greatly without noticeable variation of the computational complexity.

  7. spa typing for epidemiological surveillance of Staphylococcus aureus

    NARCIS (Netherlands)

    Hallin, Marie; Friedrich, Alexander W; Struelens, Marc J; Caugant, Dominique A.

    2009-01-01

    The spa typing method is based on sequencing of the polymorphic X region of the protein A gene (spa), present in all strains of Staphylococcus aureus. The X region is constituted of a variable number of 24-bp repeats flanked by well-conserved regions. This single-locus sequence-based typing method

  8. Post-neonatal drop in alveolar SP-A expression

    DEFF Research Database (Denmark)

    Stray-Pedersen, Arne; Vege, Ashild; Stray-Pedersen, Asbjorg

    2008-01-01

    BACKGROUND: Surfactant protein A (SP-A) is synthesized in the lung and is a part of the innate immune system. The aim of this study was to evaluate the expression of SP-A in lung tissue from fetuses, infants, children and adults with special regard to sudden infant death syndrome (SIDS). METHODS......: A total of 160 cases were studied; 19 fetuses and neonates, 59 SIDS and 49 explained infant deaths below 1 year of age, 19 toddlers and 14 adults. Immunohistochemical detection of SP-A using monoclonal antibodies was performed by microscopy of lung tissue specimens collected at autopsy. A scoring system...... was developed enabling semi-quantitative estimation of staining intensity and distribution. RESULTS: SP-A was detected in the terminal bronchioles and alveolar spaces of fetuses >35 weeks gestation. The intra-alveolar SP-A expression increased in the perinatal period followed by a marked drop in infants aged...

  9. Spa and Wellness Tourism in Slovakia (A Geographical Analysis

    Directory of Open Access Journals (Sweden)

    Kasagranda Anton

    2017-06-01

    Full Text Available Spa industry is presently an inherent part of Slovak tourism. For this reason, it has become a major interest of scientific and professional literature (economics, management, sociology, or geography. The main topic of this paper is the evaluation of tourism in Slovakia through a geographic analysis. This paper briefly evaluates the development and the importance of spa, spa tourism and wellness and their main research areas and issues. Furthermore, the primary sources of tourism development, the overview of spa tourism and the wellness resorts, the accommodation establishments and the visitation rate are evaluated as well. In conclusion, functional and spatial typification of spa tourism and wellness in Slovakia is presented. The structure of the paper is designed to be appropriate for a comparison with V4 countries.

  10. Spa Goers' Repeated Visits for Health and Wellness and the Influential Factors: An Exploratory Study of the UK Spa Goers.

    Science.gov (United States)

    Choi, Myungsuk; Poade, Donna; Sohn, Minsung; Choi, Mankyu

    2016-01-01

    Dissemination of spa services across the globe and its market saturation drive demand for differentiated communication methods. This study aims to explore the influential factors on spa goers' repeated visits and their practical applications in the health and wellness spa industry. The identified factors were used as the measurement variables to examine the relation with spa goers' repeated visits. The proposed concept was tested by a mixed method combining a self-administered questionnaire and semistructured interview with 54 survey participants and 6 interviewees. It was meaningful to use a sample of the UK spa goers from the southwest region since global spa trends stem from the EU spas, and the United Kingdom is one of the market leaders. The data were analyzed using frequency, percentage, multiple logistic regression analysis, and coding process. The survey findings demonstrated that the most significant influential factor on the repeated spa visits is a memorable experience of which showed 13.7 times higher probability than the reference up-to-date facility. The details of memorable experiences were discovered throughout the interviews that include the rediscovery of self, feeling of connectedness, recharge for positive emotions, self-reward through escapism, and experience of noncommercialized local products and attractions. Therefore, using experiential marketing methods can be effective spa service marketing.

  11. Spa treatment of Chernobyl liquidators in Israel

    International Nuclear Information System (INIS)

    Godovich, A.; Chernovskij, A.; Lyass, F.; Shapiro, I.; Kratov, Eh.; Markarov, G.

    1997-01-01

    This paper presents the first experience gained in the use of the unique climate and spa of the Dead Sea for the treatment and rehabilitation of the Chernobyl liquidators at clinic near the city of Arad. Ninety-six patients were treated in Israel, in 40 of these radiation was the etiological factor of the disease: consequences of acute and chronic radiation disease, the astheno-neurotic syndrome, discirculatory encephalopathy, subatrophic laryngopharyngitis, and obstructive bronchitis. Eighty-eight patients had direct indications for treatment at the Dad Sea; locomotory, respiratory, and skin diseases. The course of treatment included the Dad Sea baths, mud applications, sun baths, climatotherapy, physiotherapy, massage, bioenergy therapy, inhalations, moisturizing creams, etc. An appreciable improvement with resolution of the principal symptoms was attained in 82% of patients, in 13% improvement with a significant abatement of the symptoms was achieved, whereas in 5% no apparent results were seen

  12. Staphylococcus aureus spa type t437

    DEFF Research Database (Denmark)

    Glasner, C; Pluister, G; Westh, H

    2015-01-01

    Methicillin-resistant Staphylococcus aureus (MRSA) belonging to the multilocus sequence type clonal complex 59 (MLST CC59) is the predominant community-associated MRSA clone in Asia. This clone, which is primarily linked with the spa type t437, has so far only been reported in low numbers among...... included. Most isolates were shown to be monophyletic with 98% of the isolates belonging to the single MLVA complex 621, to which nearly all included isolates from China also belonged. More importantly, all MLST-typed isolates belonged to CC59. Our study implies that the European S. aureus t437 population...... large epidemiological studies in Europe. Nevertheless, the overall numbers identified in some Northern European reference laboratories have increased during the past decade. To determine whether the S. aureus t437 clone is present in other European countries, and to assess its genetic diversity across...

  13. State, planning and design of Jodna spa in Novi Sad

    OpenAIRE

    Garača Vuk; Ćurčić Nevena; Vukosav Svetlana

    2012-01-01

    The paper treats the area of Jodna spa in Novi Sad, which largely coincides with Futoški park, making with it the indissoluble unity. The main problem in the functioning of the Jodna psa is the fact that in legal sense Jodna spa does not exists, and in spatial sense there are still all of its content. The case of the paper is Jodna spa area, which includes the Special Hospital for Rheumatic Diseases, Hotel 'Park', Sports Center 'Sajmište' and Futoški park, which integrate them. The question o...

  14. Motivações para a procura de SPA Tourism

    OpenAIRE

    Ferreira, Leticia; Silva, Carla; Seabra, Cláudia

    2018-01-01

    O SPA Tourism é atualmente um dos maiores sectores turísticos em crescimento. O SPA Tourism é uma variante do turismo de saúde e bem-estar a que se têm associado conceitos como o bemestar, felicidade, qualidade de vida, práticas holísticas e crenças espirituais. Não obstante, a importância e o crescente interesse sobre turismo de saúde e bem-estar, são ainda escassos os estudos focados em SPA Tourism particularmente no que diz respeito aos determinantes de procura deste tipo de turismo, das p...

  15. PERFORMANCE ANALYSIS ON SPA SERVICE AT BADUNG DAN GIANYAR REGENCIES

    Directory of Open Access Journals (Sweden)

    Dewa Ayu i Laksmiadi Janapriat

    2016-03-01

    Full Text Available Over the last ten years, spa as one of the products of wellness tourism is growing very fast in Bali, necessitating the development strategy in accordance with the conditions of Bali. The rapid development momentum for the business of spa is opened in Bali, although in the external side of the business will compete with the international trade environment to take advantage and create sustainable economic growth prospects. This will be an opportunity for Bali as a destination spa in the future. In an effort to maintain and continue to develop quality as the best spa destinations in the world, we need the right strategy to make the creation and supporting product innovation spa in Bali. This study aims to create an integrated assessment of the extent of the influence of the utilization of natural resources, human resources and local knowledge of the existence and essence of spa in Bali and methods for utilizing natural resources, human resources and local knowledge of Bali on development of spa in Bali. Research design and methods of approach to the problem that are done in this study using descriptive design, where the planning and execution of research conducted in the form of field data are collected in the form of surveys, questionnaires and statistical data processing. The target population in this study is divided into three, namely: the company or a place that offers spa services, spa services supporting manufacturers and both foreign and domestic tourists who use the services of spa services in Badung and Gianyar, by assuming the two districts can represent the tourist population to Bali. Based on several case studies found that the performance of spa services in terms of utilization of natural resources, human resources, and local wisdom of Bali, particularly in terms of (1 the atmosphere (ambience, (2 equipment and design, (3 the qualifications and skills of the therapist, (4 treatment menu, and (5 the quality of services as a whole has

  16. Correlation of the sperm penetration assay (SPA and miscarriage after assisted reproduction: The potential use of spa as a new criterion for preimplantation genetic diagnosis

    Directory of Open Access Journals (Sweden)

    Gradistanac Jelena

    2011-01-01

    Full Text Available We analyzed 93 couples undergoing male screening with the Sperm Penetration Assay (SPA before in vitro fertilization and intracytoplasmic sperm injection (ICSI, to determine the accuracy of SPA for subsequent embryonic development, incidence of pregnancy and miscarriage rates (SAB. ICSI patients with the lowest SPA scores had significantly higher incidences of Sthan did patients in the other SPA groups. Sperm quality is higher with better SPA scores. Poor sperm quality has increased incidence of chromosomal abnormalities and is associated with early fetal loss. Couples with negative SPA are candidates for preimplantation genetic diagnosis, to reduce the incidence of SAB.

  17. Microfibril-associated Protein 4 Binds to Surfactant Protein A (SP-A) and Colocalizes with SP-A in the Extracellular Matrix of the Lung

    DEFF Research Database (Denmark)

    Schlosser, Anders; Thomsen, Theresa H.; Shipley, J. Michael

    2006-01-01

    Pulmonary surfactant protein A (SP-A) is an oligomeric collectin that recognizes lipid and carbohydrate moieties present on broad range of micro-organisms, and mediates microbial lysis and clearance. SP-A also modulates multiple immune-related functions including cytokine production and chemotaxis......-A composed of the neck region and carbohydrate recognition domain of SP-A indicating that the interaction between MFAP4 and SP-A is mediated via the collagen domain of SP-A. Monoclonal antibodies directed against MFAP4 and SP-A were used for immunohistochemical analysis, which demonstrates that the two...

  18. Impact to Tourism Industry of Massage Spa Therapy in Batangas City, Philippines

    OpenAIRE

    Kimmy Lei T. Atienza; Claire A. Evangelista; Lalaine I. Evangelista; Richell T. Ibre; Karen Mae D. Macalalad; Sevilla S.Felicen; Kabaitan Dinglasan

    2014-01-01

    This study aimed to assess the benefits of massage spa therapy in tourism industry of Batangas City and their adherence to the standards to DOT on Spa operation and maintenance. The study aimed to identify the profile of massage spa in terms of type of ownership, length of years in the business, type of spa and different spa services offered; to assess the benefits of massage spa to the tourism industry; and to determine the extent of adherence of the massage spa to DOT standards ...

  19. Allegheny County Public Swimming Pool, Hot Tub, and Spa Inspections

    Data.gov (United States)

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — Public swimming pool, hot tub, and spa facilities are licensed and inspected once each year to assure proper water quality, sanitation, lifeguard coverage and...

  20. The quality of spa services and possibilities of their improvement

    OpenAIRE

    Issentayeva, Alma

    2011-01-01

    This thesis analyzes the quality of the spa services. The aim of this paper is to assess the quality of the services provided in the wellness hotel President and to propose to the hotel management options to improve the services.

  1. [Extensive treatment of teacher's voice disorders in health spa].

    Science.gov (United States)

    Niebudek-Bogusz, Ewa; Marszałek, Sławomir; Woźnicka, Ewelina; Minkiewicz, Zofia; Hima, Joanna; Sliwińska-Kowalska, Mariola

    2010-01-01

    Treatment in a health spa with proper infrastructure and professional medical care can provide optimal conditions for intensive voice rehabilitation, especially for people with occupational voice disorders. The most numerous group of people with voice disorders are teachers. In Poland, they have an opportunity to take care of, or regain, their health during a one-year paid leave. The authors describe a multi-specialist model of extensive treatment of voice disorders in a health spa, including holistic and interdisciplinary procedures in occupational dysphonia. Apart from balneotherapy, the spa treatment includes vocal training exercises, relaxation exercises, elements of physiotherapy with the larynx manual therapy and psychological workshops. The voice rehabilitation organized already for two groups of teachers has been received with great satisfaction by this occupational group. The implementation of a model program of extensive treatment of voice disorders in a health spa should become one of the steps aimed at preventing occupational voice diseases.

  2. DIRECTIONS OF DEVELOPMENT OF THE ROMANIAN SPA TOURISM

    OpenAIRE

    Anca Gabriela TURTUREANU

    2007-01-01

    Development of tourism in Romania must be both an aim and a means to obtain general social-economic development taking into consideration the circumstances of the national policy of development and integration within the European structure. The development of the Romanian spa tourism is triggered by Romania's macroeconomic development, by better regulation of problems which this form of tourism faces as well as by the involvement of Romania's Government in supporting Romanian spa tourism.

  3. DIRECTIONS OF DEVELOPMENT OF THE ROMANIAN SPA TOURISM

    Directory of Open Access Journals (Sweden)

    Anca Gabriela Turtureanu

    2007-05-01

    Full Text Available Development of tourism in Romania must be both an aim and a means to obtain general socialeconomicdevelopment taking intoconsideration the circumstances of the national policy of development andintegration within the European structure. The development of the Romanian spa tourism is triggered byRomania's macroeconomic develoment, by better regulation of problems which this form of tourism faces aswell as by the involvement of Romania's Government in supporting Romanian spa tourism.

  4. MANAGEMENT AND DEVELOPMENT POSSIBILITIES FOR SPA TOURISM IN SERBIA

    Directory of Open Access Journals (Sweden)

    Nemanja BERBER

    2010-06-01

    Full Text Available Two forms of tourism, which are represented to a large extent in the world, are spa and wellness tourism. In Serbia, spa and wellness tourism are not sufficiently used, although there are excellent conditions. During twenty century the state was paying more attention and money on the sea and river tourism. However, the separation of Serbia and Montenegro in two independent counties had left Serbia without an entrance to the Adriatic Sea, so development of other tourist products and destinations became an imperative for survival and existence in the tourist map of Europe and the world. The paper presents the basic aims and policies of development of spa tourism in Serbia and data obtained in the survey regarding quality of services provided in some spa towns in Serbia. Based on the results to which the research occurred, authors wished to point out main activities and tasks that the state uses in creating a development strategy of spa tourism, the programs that have already been taken, so as the influence of the economic crisis to spa tourism.

  5. Advancing the Economies through SPA Industry

    Directory of Open Access Journals (Sweden)

    Vandana DESWAL

    2015-12-01

    Full Text Available This paper is an attempt to present a clear picture of how important is spa industry in promoting tourism and the ways in which it can be made instrumental in drawing tourists from various places to a destination. People have been visiting places famous for their spas since ancient times. People would visit places famous for their healing waters and stay there for days. Romans and Greeks were known for their luxurious baths devoted to relaxation and rejuvenation. Recently, spas are witnessing a revival of interest in them and they are becoming a force to reckon with in the hospitality sector. This research is an attempt to understand the role spas are playing in stimulating tourism of the place. A survey of 200 people was conducted and the responses were taken on a Likert like scale for the purpose of percentage analysis. It was found that Spas and Tourism of a destination have very symbiotic relationship and if harnessed well, spas can substantially add to the tourism of the place.

  6. Hypersensitivity pneumonitis with Mycobacterium avium complex among spa workers.

    Science.gov (United States)

    Moraga-McHaley, Stephanie Ann; Landen, Michael; Krapfl, Heidi; Sewell, C Mack

    2013-01-01

    The New Mexico Department of Health (NMDOH) investigated the cause of two cases of hypersensitivity pneumonitis (HP) in spa maintenance workers with laboratory confirmed Mycobacterium avium complex (MAC). The investigation occurred in tandem with worker protection and swimming pool regulatory investigations by the New Mexico Environment Department at the spa where the workers were employed. The investigation was conducted in order to identify unreported cases, exposure source(s), and to prevent further worker exposure. NMDOH surveyed 57 spa employees about symptoms and exposures, categorized jobs according to self-reported exposure to water, and computed odds ratios for symptom reporting by exposure category. Environmental isolates from spa water and filter swabs were cultured and compared to patient isolates by the Environmental and Applied Microbiology Team, Centers for Disease Control and Prevention (CDC). Workers with the highest exposure reported more HP-like symptoms (OR = 9.6), as did intermediate exposure workers (OR = 6.5), compared to workers with no aerosolized water exposure. Two of 13 environmental isolates were closely related to one of the patient isolates. Workers were likely exposed during spray cleaning of cartridge filters in a poorly ventilated work space. Recommendations include inhibiting organism growth in spa systems, assuring the use of respiratory protection, and adequately ventilating work spaces where filters and equipment are cleaned.

  7. "Roman Baths" in Contemporary Spa Tourism

    Directory of Open Access Journals (Sweden)

    Vesna Merc

    2005-07-01

    Full Text Available The commercialisation of images and symbols from antiquity, so characteristic of Slovenia since its independence, has been reflected over the last decade in spa tourism as well. Since the great crises in the sixties, and especially since the eighties, fifteen Slovene natural health resorts have concentrated on developing wellness and activities programs. This change in orientation has been accompanied by renovations, an expansion of the water surfaces and capacities, and new wellbeing, wellness, spirituality and beauty programs. An analysis of Slovene spas, wellness centres and hotel web pages shows that they frequently offer rooms, usually saunas, which are imitations of the Roman baths. These rooms are usually called "Roman saunas", "Tepidarium", "Caldarium", and "Roman-Irish baths". At Terme Ptuj, Zdravilišče Laško, Šmarješke Toplice, Grand Hotel Palace in Portorož, and Terme Čatež, saunas have been built or renovated in the Roman style. This trend of Roman rooms is a novelty, less than a decade old in Slovenia. The first sauna with a Roman theme, a Roman-Irish bath, was opened in 1997 in the Health and Beauty Centre at Terme Čatež. Modern Roman saunas are very popular, found not only in Slovenia but also in other parts of Europe, especially Germany and Austria. Their popularity has spread from the areas formerly occupied by the Romans to other parts of world, for example the USA and the Republic of South Africa. An analysis of Slovene saunas and wellness centres reveals a well-established trend to recreate certain parts of the Roman baths. This is attempted not only through Roman-style decorations, but also through certain structures particular to the Roman baths, such as the caldarium, tepidarium, and in one case even a laconicum. The approach, however, is highly eclectic, blending Roman, Greek and, above all, modern elements. The purpose of such rooms is to increase the appeal of the spas, while their design is mostly based on

  8. Spa and Wellness Tourism in Poland - A New Geographical Analysis

    Directory of Open Access Journals (Sweden)

    Widawski Krzysztof

    2017-06-01

    Full Text Available The aim of the paper is to present the situation of the spa resorts in Poland from the geographical point of view, emphasizing especially the tourist context of their existence. This article firstly deals with the brief history of spas in Poland and the definition of the phenomenon, presented in the Polish literature and legal acts. The main part of the paper presents the geographical analysis of the phenomenon: spatial distribution of the activities allowed by law, localization concerning the different kind of landscapes that accompanies the spas, natural and curative resources and the medical treatments based on their potential. In addition, the tourist context analysed with the support of the statistical data of the accommodation units, tourist sand its preferences, and health tourist establishments in the spa resorts and its usage is also crucial. The perspectives of the spa tourism development in Poland concerning the potential and obstacles are presented.

  9. PERSPECTIVES OF DEVELOPMENT OF SPA TOURISM IN SERBIA

    OpenAIRE

    PERIC, Lecturer Goran; Stojiljković, Marija; Gašić, Marko; Ivanović, PhD. Vladan

    2017-01-01

    Serbia abounds in thermal mineral springs, which are not tourist valorized and used in the proper way. With more than 50 spas and more than 1000 springs, of which about 500 springs of cold and hot mineral water, as well as the abundance of natural gas and mineral mud, has a huge potential in spa tourism. Because of that, Serbia is so-called “Spa country”. According to the number of overnights and arrivals, spas are the leading tourist destinations in Serbia. The subject of this paper refers t...

  10. Spa-goers’ Characteristics, Motivations, Preferences and Perceptions: Evidence from Elounda, Crete

    OpenAIRE

    Nikolaos Trihas; Anastasia Konstantarou

    2016-01-01

    Spa and wellness tourism is one of the fastest-growing market segments in the hospitality and tourism industry. The aim of this study is to investigate and identify spa-goers’ characteristics, motivations, preferences and perceptions, providing a better understanding of the main features of this type of tourists’ behavior and expectations from a spa and wellness centre. Primary quantitative research was conducted via a structured questionnaire in a sample of 123 spa customers at Elounda in Cr...

  11. Non-spa-typeable clinical Staphylococcus aureus strains are naturally occurring protein A mutants

    DEFF Research Database (Denmark)

    Baum, Cathrin; Haslinger-Löffler, Bettina; Westh, Henrik

    2009-01-01

    Staphylococcus aureus is a major human pathogen responsible for increasing the prevalence of community- and hospital-acquired infections. Protein A (SpA) is a key virulence factor of S. aureus and is highly conserved. Sequencing of the variable-number tandem-repeat region of SpA (spa typing) prov...

  12. Kalev SPA veekeskus sulges teadmata ajaks uksed / Kaire Uusen

    Index Scriptorium Estoniae

    Uusen, Kaire

    2008-01-01

    Vt. ka Postimees : na russkom jazõke 3. juuli. Kalev SPA veekeskuse juht Evelin Männik räägib kloorimürgistusega lõppenud õnnetuse põhjustest. Vt. samas: Kloorimürgistuse tagajärjed võinuks olla palju hullemad

  13. Spa Tourism – a comparative analysis on Spain and Romania

    Directory of Open Access Journals (Sweden)

    Aluculesei Alina-Cerasela

    2015-09-01

    Full Text Available Spa tourism is one of the oldest forms of tourism, capitalizing on the curative properties of mineral waters ever since antiquity. At first, the results of such treatments were questioned by health professionals, but the results of numerous studies conducted on the properties of these therapeutic factors have earned them the credibility needed in order to be prescribed by general practitioners as complementary forms of treatment. Spa tourism is becoming increasingly important in Romania and Spain, especially since both countries are characterized by low birth rates, making health care for the elderly population a priority. The annual spa cure is encouraged with social programs such as "One Week of Recovery" or IMSERSO which facilitate the purchase of health tourism packages for retired citizens. This research is aimed at highlighting modern health tourism through a comparative analysis of two hotel units specialized in spa treatments, one in Romania and one in Spain. In order to collect the information I used the interview method, the observation method and desk research - in the case of information generated from the online environment. The data were collected between January and May 2015.

  14. Pürovel Spa & Sport / Ülli Plink

    Index Scriptorium Estoniae

    Plink, Ülli, 1973-

    2011-01-01

    Swissôtel Tallinna 11. korrusel asuvast Pürovel Spa & Sport poolt pakutavatest treeningutest ning lõõgastusprotseduuridest, samuti 8. korrusel asuvast a la carte menüü ja päevabuffega restoranist Café Swiss

  15. PERSEPSI MASYARAKAT SURABAYA TERHADAP SPA SEBAGAI SARANA PERAWATAN KESEHATAN, KEBUGARAN DAN KECANTIKAN

    Directory of Open Access Journals (Sweden)

    Peter Remy Yosy Pasla

    2004-01-01

    Full Text Available Spa (Sanus Per Aquam or Solus Per Aqua as a health and beauty care method coherence with various elements include in the Ten Elements of Spa Experience, through the spirit, body, and mind approach, creates a balance between spirit, body, and mind (reflect, a relax atmosphere that could revitalize, and revives the joy (rejoice, and now supported with various facilities and resources, Spa could be an option of healing and therapy. Beautician and beauty clinics who offer Spa as their menu and facilities, but misconceive the meaning and concept of Spa probably make people unwilling to try and have a negative impression about Spa. It will cause a distortion in forming a perception, and also could affect the perception of people about business image of Spa. Abstract in Bahasa Indonesia : Spa (Sanus Per Aquam atau Solus Per Aqua sebagai salah satu metode perawatan kebugaran dan kecantikan yang dipadukan dengan berbagai elemen yang tercakup dalam the Ten Elements of Spa Experience, melalui pendekatan jiwa (spirit, raga (body dan pikiran (mind, menciptakan keseimbangan antara jiwa, raga, dan pikiran (reflect, dan nuansa rileks (relax yang dapat menumbuhkan kembali vitalitas (revitalize serta mengembalikan keceriaan (rejoice, dan dengan didukung berbagai fasilitas dan sumber daya saat ini, Spa juga dapat menjadi pilihan terapi dan penyembuhan. Adanya salon dan klinik kecantikan yang menawarkan fasilitas dan menu Spa tetapi kurang memahami arti dan konsep Spa mungkin saja mjembuat masyarakat menjadi enggan untuk mencoba dan memiliki kesan negatif akan Spa. Hal tersebut dapat menjadi faktor distorsi pada pembentukan persepsi, dan mungkin saja mempengaruhi persepsi masyarakat Surabaya terhadap image/citra bisnis Spa. Kata kunci: Spa, Persepsi.

  16. Impact to Tourism Industry of Massage Spa Therapy in Batangas City, Philippines

    Directory of Open Access Journals (Sweden)

    Kimmy Lei T. Atienza

    2014-10-01

    Full Text Available This study aimed to assess the benefits of massage spa therapy in tourism industry of Batangas City and their adherence to the standards to DOT on Spa operation and maintenance. The study aimed to identify the profile of massage spa in terms of type of ownership, length of years in the business, type of spa and different spa services offered; to assess the benefits of massage spa to the tourism industry; and to determine the extent of adherence of the massage spa to DOT standards about spa operation and maintenance; and propose a plan of action based on the results of the study. Descriptive method was used in the study. Results showed that the Sole Proprietorship got the highest rank in terms of type of ownership. With the length of years in service, it shows that most of spa business already exists for 4-6 years. Type of spa shows that majority of the spa business were Spa Town. With regards to different spa services, majority offers peat pulp bath and the least is sauna and steam bath. The over-all assessment of the respondents’ on the benefits of spa was agree by the result. It was also observed that all items were assessed as agree and it enhances the awareness of the tourists about the beauty of Batangas City. It was followed by provide taxes for the government, became a tourist attraction and improves socio-economic of local residents and improvement on the lifestyle both of the local residents and tourists

  17. A mechanism for extremely weak SpaP-expression in Streptococcus mutans strain Z1

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    Yutaka Sato

    2011-04-01

    Full Text Available Background: Streptococcus mutans surface-protein antigen (SpaP, PAc, or antigen I/II has been well known to play an important role in initial attachment to tooth surfaces. However, strains with weak SpaP-expression were recently reported to be found in natural populations of S. mutans. The S. mutans gbpC-negative strain Z1, which we previously isolated from saliva and plaque samples, apparently expresses relatively low levels of SpaP protein compared to S. mutans strains MT8148 or UA159. Objective: To elucidate the mechanism for weak SpaP-expression in this strain, the spaP gene region in strain Z1 was amplified by polymerase chain reaction (PCR and analyzed. Methods: Allelic exchange mutants between strains Z1 and UA159 involving the spaP gene region were constructed. The SpaP protein expressed in the mutants was detected with Coomasie Brilliant Blue (CBB-staining and Western blot analysis following SDS-PAGE. Results: The 4689 bp spaP gene coding sequence for Z1 appeared to be intact. In contrast, a 20 bp nucleotide sequence appeared to be deleted from the region immediately upstream from the Z1 spaP gene when compared to the same region in UA159. The 216 bp and 237 bp intergenic fragments upstream from the spaP gene, respectively, from Z1 and UA159 were isolated, modified, and transformed into the other strain by allelic replacement. The resultant UA159-promoter region-mutant exhibited extremely weak SpaP-expression similar to that of strain Z1 and the Z1 complemented mutant expressed Spa protein levels like that of strain UA159. Conclusion: These results suggest that weak SpaP-expression in strain Z1 resulted from a 20 bp-deletion in the spaP gene promoter region.

  18. Characterization of the SpaCBA Pilus Fibers in the Probiotic Lactobacillus rhamnosus GG

    Science.gov (United States)

    Reunanen, Justus; von Ossowski, Ingemar; Hendrickx, Antoni P. A.; Palva, Airi

    2012-01-01

    Lactobacillus rhamnosus GG is a human intestinal isolate that has been studied intensively because of its probiotic properties. We have previously shown that L. rhamnosus GG produces proteinaceous pili that earlier had been observed only in Gram-positive pathogens (M. Kankainen et al., Proc. Natl. Acad. Sci. U. S. A. 106:17193–17198, 2009). These pili were found to be encoded by the spaCBA gene cluster, and the pilus-associated SpaC pilin was shown to confer on the cells a mucus-binding ability. In addition to the spaCBA cluster, another putative pilus cluster, spaFED, was predicted from the L. rhamnosus GG genome sequence. Herein, we show that only SpaCBA pili are produced by L. rhamnosus, and we describe a detailed analysis of cell wall-associated and affinity-purified SpaCBA pili by Western blotting and immunogold electron microscopy. Our results indicate that SpaCBA pili are heterotrimeric protrusions with a SpaA subunit as the shaft-forming major pilin. Only a few SpaB subunits could be observed in pilus fibers. Instead, SpaB pilins were found at pilus bases, as assessed by immunogold double labeling of thin sections of cells, suggesting that SpaB is involved in the termination of pilus assembly. The SpaC adhesin was present along the whole pilus length at numbers nearly equaling those of SpaA. The relative amount and uniform distribution of SpaC within pili not only makes it possible to exert both long-distance and intimate contact with host tissue but also provides mucus-binding strength, which explains the prolonged intestinal residency times observed for L. rhamnosus GG compared to that of nonpiliated lactobacilli. PMID:22247175

  19. Characterization of the SpaCBA pilus fibers in the probiotic Lactobacillus rhamnosus GG.

    Science.gov (United States)

    Reunanen, Justus; von Ossowski, Ingemar; Hendrickx, Antoni P A; Palva, Airi; de Vos, Willem M

    2012-04-01

    Lactobacillus rhamnosus GG is a human intestinal isolate that has been studied intensively because of its probiotic properties. We have previously shown that L. rhamnosus GG produces proteinaceous pili that earlier had been observed only in Gram-positive pathogens (M. Kankainen et al., Proc. Natl. Acad. Sci. U. S. A. 106:17193-17198, 2009). These pili were found to be encoded by the spaCBA gene cluster, and the pilus-associated SpaC pilin was shown to confer on the cells a mucus-binding ability. In addition to the spaCBA cluster, another putative pilus cluster, spaFED, was predicted from the L. rhamnosus GG genome sequence. Herein, we show that only SpaCBA pili are produced by L. rhamnosus, and we describe a detailed analysis of cell wall-associated and affinity-purified SpaCBA pili by Western blotting and immunogold electron microscopy. Our results indicate that SpaCBA pili are heterotrimeric protrusions with a SpaA subunit as the shaft-forming major pilin. Only a few SpaB subunits could be observed in pilus fibers. Instead, SpaB pilins were found at pilus bases, as assessed by immunogold double labeling of thin sections of cells, suggesting that SpaB is involved in the termination of pilus assembly. The SpaC adhesin was present along the whole pilus length at numbers nearly equaling those of SpaA. The relative amount and uniform distribution of SpaC within pili not only makes it possible to exert both long-distance and intimate contact with host tissue but also provides mucus-binding strength, which explains the prolonged intestinal residency times observed for L. rhamnosus GG compared to that of nonpiliated lactobacilli.

  20. Spa Garden in Daruvar – Methods of Renewal and Reconstruction

    Directory of Open Access Journals (Sweden)

    Šćitaroci Mladen Obad

    2014-12-01

    Full Text Available Spa garden in Daruvar ‘Julius’s Park’ is the oldest spa garden in continental Croatia. The counts Jankovich and their successors created the garden during the 18th and 20th century. The garden resumed its nowadays form and surface in the time of count Julius Jankovich in the mid-19th century and it was named after him. The garden is protected as a cultural heritage. The garden’s renovation is seen as an urban, architectural and landscape unity and it attempts to affirm the missing and neglected parts of the garden, to provide technological and municipal space modernization and to make a pleasant urban garden ambiance with new facilities and high space arrangement qualities, contributing to the economic development of the local community.

  1. Hydrogeothermal characteristics of groundwater from Ribarska Banja spa, central Serbia

    Directory of Open Access Journals (Sweden)

    Dragišić Veselin S.

    2015-01-01

    Full Text Available Ribarska Banja spa is one of the most popular balneotherapy and recreation centers in Serbia. It features several thermal groundwater sources whose temperatures range from 26 to 54°C. The mineral content of these waters is low and their composition is of the SO4-Na or HCO3-Na type. Thermal water exploration has been conducted in the general area for many years, to assess the hydrogeothermal potential in order to extract larger amounts of thermal water for multiple uses. The hydrogeothermal system of Ribarska Banja spa was defined based on a synthesis of the results of comprehensive structural geology, geophysical, hydrogeological, hydrochemical and geothermal research. The primary groundwater reservoir of the hydrogeothermal system is comprised of tectonic zones (systems of faults and fractures within Cretaceous-Paleogene metamorphosed and non-metamorphosed rocks. The overlying hydrogeological and temperature barrier is made up of a series of low metamorphosed rocks (chlorite, chlorite-sericite schists, gabbros, etc., highly metamorphosed rocks (gneisses and Neogene clay and sand sediments. The system is recharged by infiltration of atmospheric precipitation and surface water at the highest elevations of Mt. Jastrebac. Investigations have also shown that the system’s heat source is younger granitoide intrusion spreading northwest of Ribarska Banja spa. Based on the quartz geothermometers, expected reservoir temperatures are in the range of 85-97°C that can be expected at a depth of 1.87 km. Total energy usage at Ribarska Banja spa is 31 TJ/y with thermal capacity of 1.65 MWt and utilization factor of 0.58. Geothermal gradient is 0,051°C/m, while heat flow density is 163.5 mW/m2. [Projekat Ministarstva nauke Republike Srbije, br. 43004

  2. Supersymmetry Parameter Analysis: SPA Convention andProject

    Energy Technology Data Exchange (ETDEWEB)

    Aguilar-Saavedra, J.A.; Ali, A.; Allanach, B.C.; Arnowitt, R.; Baer, H.A.; Bagger, J.A.; Balazs, C.; Barger, V.; Barnett, M.; Bartl, A.; Battaglia, M.; Bechtle, P.; Belanger, G.; Belyaev, A.; Berger, E.L.; Blair, G.; Boos, E.; Carena, M.; Choi, S.Y.; Deppisch, F.; De Roeck, A.; /Lisbon, IST /DESY /Cambridge U., DAMTP /Texas A-M /Florida State

    2005-12-02

    High-precision analyses of supersymmetry parameters aim at reconstructing the fundamental supersymmetric theory and its breaking mechanism. A well defined theoretical framework is needed when higher-order corrections are included. We propose such a scheme, Supersymmetry Parameter Analysis SPA, based on a consistent set of conventions and input parameters. A repository for computer programs is provided which connect parameters in different schemes and relate the Lagrangian parameters to physical observables at LHC and high energy e{sup +}e{sup -} linear collider experiments, i.e., masses, mixings, decay widths and production cross sections for supersymmetric particles. In addition, programs for calculating high-precision low energy observables, the density of cold dark matter (CDM) in the universe as well as the cross sections for CDM search experiments are included. The SPA scheme still requires extended efforts on both the theoretical and experimental side before data can be evaluated in the future at the level of the desired precision. We take here an initial step of testing the SPA scheme by applying the techniques involved to a specific supersymmetry reference point.

  3. Radioactivity of water and air in Misasa Spa, Japan

    International Nuclear Information System (INIS)

    Morinaga, H.; Mifune, M.; Furuno, K.

    1984-01-01

    Misasa Spa is one of the most highly radioactive hot springs in Japan, the waters of which contain mainly 222 Rn (437 +- 132 Bq.litre -1 ). Radon contents of indoor air of private houses and health resort hotels (built of wood) at Misasa Spa range from 18.5 to 55.5 mBq.litre -1 and 22.2 to 129.5 mBq.litre -1 , respectively. Radon contents in the air of facilities using spring waters at Misasa Branch Hospital of Okayama University were measured to be: bathroom 807 +- 78 mBq.1 -1 , Hubbard-tank bathroom, 5306 +- 2568 mBq.litre -1 ; the drinking hall, 1491 +- 178 mBq.litre -1 . The environmental and dose rate inside private houses has been measured to be 14.0 +- 1.8 μR.h -1 . Chromosome abberations (dicentrics) in the peripheral blood lymphocytes of residents of Misasa Spa were investigated in 14 persons; the mean value of aberration frequencies were 0.21%. (author)

  4. Radioactivity and chromosome aberrations of residents of Misasa Spa

    International Nuclear Information System (INIS)

    Morinaga, Hiroshi; Mifune, Masaaki; Furuno, Katsushi

    1985-01-01

    Misasa Spa is one of the most highly radioactive hot springs in Japan, the waters of which contain mainly 222 Rn (437 ± 132 Bq/liter). Radon contents of indoor air of private houses and health resort hotels (built of wood) at Misasa Spa range from 18.5 to 55.5 mBq/liter and 22.2 to 129.5 mBq/liter, respectively. Radon contents in the air of facilities using spring waters at Misasa Branch Hospital of Okayama University were measured to be; bathroom 807 ± 78 mBq/liter; Hubbardtank bathroom 5306 ± 2568 mBq/liter; the drinking hall 1491 ± 178 mBq/liter. The environmental and dose rate inside private house's has been measured to be 14.0 ± 1.8 μR/h. Chromosome aberrations (dicentrics) in the peripheral blood lymphocytes of residents of Misasa Spa were investigated in 14 persons; the mean value of aberration frequencies were 0.21 %. (Kubozono, M.)

  5. Fibromyalgia Syndrome and Spa Therapy: Myth or Reality?

    Directory of Open Access Journals (Sweden)

    Giacomo M. Guidelli

    2012-01-01

    Full Text Available Fibromyalgia syndrome (FS is a common musculoskeletal disorder characterized by otherwise unexplained chronic widespread pain, a lowered pain threshold, high tender point counts, sleep disturbances, fatigue, headache, irritable bowel syndrome, morning stiffness, paraesthesias in the extremities, often psychological distress and depressed mood. Consequently, FS has a negative impact on working capacity, family life, social functioning and quality of life. Because of unknown etiology and not clearly understood pathogenesis, there is no standard therapy regime for FS. A variety of medical treatments, including antidepressants, opioids, analgesic or non-steroidal anti-inflammatory drugs, sedatives, muscle relaxants and antiepileptics, have been used to treat FS. Currently, no pharmacological treatment for FS is consistently successful. According to recent guidelines, the optimal treatment of FS requires a multidisciplinary approach with a combination of non-pharmacological and pharmacological treatment modalities. Spa therapy is a popular treatment for FS in many European countries, as well as in Japan and Israel. However, despite their long history and popularity spa treatments are still the subject of debate and their role in modern medicine is still not clear. The objective of this review is to summarize the currently available information on clinical effects and mechanism of action of spa therapy in FS. We also provide some suggestions for further development in this area.

  6. Measurement of the radon voluminal activity in spa. Methodological guide

    International Nuclear Information System (INIS)

    Ameon, R.

    2008-01-01

    The detection of radon in a building must allow to determine if all or part of the building presents a yearly average value of the radon voluminal activity is over to one or several values of interest. The measurement of radon voluminal activity in a building is codified by the AFNOR NF M60-771 norm, relative to the methodology enforced to the radon detection in buildings. It applies to any type of buildings whatever be the type of interface, the area and the ventilation mode where the ground is the principal source of radon in inside air. In the particular case of spa facilities, the presence of radon in buildings is in relation with the ground nature but also with the water present in the buildings and close environment. The present document presents the methodology applicable to the radon detection in a spa facility. It is founded on the AFNOR NF M60-771 norm and on the results of studies realised by I.R.S.N. in three French spa facilities. The implementation of this methodology requires knowledge relative to radon and buildings. It is thus the responsibility of relevant agencies. (N.C.)

  7. Lactobacillus rhamnosus GG SpaC pilin subunit binds to the carbohydrate moieties of intestinal glycoconjugates.

    Science.gov (United States)

    Nishiyama, Keita; Ueno, Shintaro; Sugiyama, Makoto; Yamamoto, Yuji; Mukai, Takao

    2016-06-01

    Lactobacillus rhamnosus GG (LGG) is a well-established probiotic strain. The beneficial properties of this strain are partially dependent on its prolonged residence in the gastrointestinal tract, and are likely influenced by its adhesion to the intestinal mucosa. The pilin SpaC subunit, located within the Spa pili structure, is the most well studied LGG adhesion factor. However, the binding epitopes of SpaC remain largely unknown. The aim of this study was to evaluate the binding properties of SpaC to the carbohydrate moieties of intestinal glycoconjugates using a recombinant SpaC protein. In a competitive enzyme-linked immunosorbent assay, SpaC binding was markedly reduced by addition of purified mucin and the mucin oligosaccharide fraction. Histochemical staining revealed that the binding of SpaC was drastically reduced by periodic acid treatment. Moreover, in the surface plasmon resonance-based Biacore assay, SpaC bound strongly to the carbohydrate moieties containing β-galactoside at the non-reducing terminus of glycolipids. We here provide the first demonstration that SpaC binds to the oligosaccharide chains of mucins, and that the carbohydrate moieties containing β-galactoside at the non-reducing termini of glycoconjugates play a crucial role in this binding. Our results demonstrate the importance of carbohydrates of SpaC for mucus interactions. © 2015 Japanese Society of Animal Science.

  8. CoSpa: A Co-training Approach for Spam Review Identification with Support Vector Machine

    Directory of Open Access Journals (Sweden)

    Wen Zhang

    2016-03-01

    Full Text Available Spam reviews are increasingly appearing on the Internet to promote sales or defame competitors by misleading consumers with deceptive opinions. This paper proposes a co-training approach called CoSpa (Co-training for Spam review identification to identify spam reviews by two views: one is the lexical terms derived from the textual content of the reviews and the other is the PCFG (Probabilistic Context-Free Grammars rules derived from a deep syntax analysis of the reviews. Using SVM (Support Vector Machine as the base classifier, we develop two strategies, CoSpa-C and CoSpa-U, embedded within the CoSpa approach. The CoSpa-C strategy selects unlabeled reviews classified with the largest confidence to augment the training dataset to retrain the classifier. The CoSpa-U strategy randomly selects unlabeled reviews with a uniform distribution of confidence. Experiments on the spam dataset and the deception dataset demonstrate that both the proposed CoSpa algorithms outperform the traditional SVM with lexical terms and PCFG rules in spam review identification. Moreover, the CoSpa-U strategy outperforms the CoSpa-C strategy when we use the absolute value of decision function of SVM as the confidence.

  9. The Role and Importance of Spa and Wellness Tourism in Hungary's Tourism Industry

    Directory of Open Access Journals (Sweden)

    Csapó János

    2017-06-01

    Full Text Available This paper presents and highlights the role and importance of spa and wellness tourism in Hungary. Ever since tourism has played an important role in the social-economic processes of the country the leading tourism product proved to be health tourism (spa and wellness thanks to the advantageous physical geographical and social-political background. After the presentation of the country-specific theoretical system of spa and wellness, the paper examines the supply and the demand side together with competitor analysis and recent trends in spa and wellness in Hungary.

  10. Spa-goers’ Characteristics, Motivations, Preferences and Perceptions: Evidence from Elounda, Crete

    Directory of Open Access Journals (Sweden)

    Nikolaos Trihas

    2016-12-01

    Full Text Available Spa and wellness tourism is one of the fastest-growing market segments in the hospitality and tourism industry. The aim of this study is to investigate and identify spa-goers’ characteristics, motivations, preferences and perceptions, providing a better understanding of the main features of this type of tourists’ behavior and expectations from a spa and wellness centre. Primary quantitative research was conducted via a structured questionnaire in a sample of 123 spa customers at Elounda in Crete. The results of the study revealed a number of important factors that influence them when choosing a spa, namely the cleanliness and the maintenance of a spa, the staff knowledge and hygiene, the personnel behavior and courtesy, and the quality of services. In addition, the main reason for visiting the spa is for stress relief/relaxation, followed by physical health improvement and beauty treatments. Findings and discussion of this study are useful to industry practitioners (spa and wellness service providers who wish to develop appropriate marketing strategies and enhance customer satisfaction and academic researchers interested in spa and wellness tourism.

  11. Phenotypical analysis of the Lactobacillus rhamnosus GG fimbrial spaFED operon: surface expression and functional characterization of recombinant SpaFED pili in Lactococcus lactis.

    Science.gov (United States)

    Rintahaka, Johanna; Yu, Xia; Kant, Ravi; Palva, Airi; von Ossowski, Ingemar

    2014-01-01

    A noticeable genomic feature of many piliated Gram-positive bacterial species is the presence of more than one pilus-encoding operon. Paradigmatically, the gut-adapted Lactobacillus rhamnosus GG strain contains two different fimbrial operons in its genome. However, whereas one of these operons (called spaCBA) is encoding for the functionally mucus-/collagen-binding SpaCBA pilus, for the other operon (called spaFED) any native expression of the SpaFED-called pili is still the subject of some uncertainty. Irrespective of such considerations, we decided it would be of relevance or interest to decipher the gross structure of this pilus type, and as well assess its functional capabilities for cellular adhesion and immunostimulation. For this, and by following the approach we had used previously to explicate the immuno-properties of SpaCBA pili, we constructed nisin-inducible expression clones producing either wild-type or SpaF pilin-deleted surface-assembled L. rhamnosus GG SpaFED pili on Lactococcus lactis cells. Using these piliated lactococcal constructs, we found that the pilin-polymerized architecture of a recombinant-produced SpaFED pilus coincides with sequence-based functional predictions of the related pilins, and in fact is prototypical of those other sortase-dependent pilus-like structures thus far characterized for piliated Gram-positive bacteria. Moreover, we confirmed that among the different pilin subunits encompassing spaFED operon-encoded pili, the SpaF pilin is a main adhesion determinant, and when present in the assembled structure can mediate pilus binding to mucus, certain extracellular matrix proteins, and different gut epithelial cell lines. However, somewhat unexpectedly, when recombinant SpaFED pili are surface-attached, we found that they could not potentiate the existing lactococcal cell-induced immune responses so elicited from intestinal- and immune-related cells, but rather instead, they could dampen them. Accordingly, we have now provided

  12. The formation of the hot springs at Bath Spa, UK

    OpenAIRE

    Gallois, Ramues

    2007-01-01

    The hot springs that emerge at 46 °C in the centre of Bath Spa, Somerset, are unique in the UK. The four other thermal springs in Britain are also sourced in the Carboniferous Limestone, but they emerge at significantly lower temperatures (20 to 28 °C). Bath is situated in a region of low geothermal gradient (about 20 °C/km depth) in a geological setting that seems an unlikely place for hot springs. Why then are these the only hot springs in Britain, and why are they confined to such a small ...

  13. A online credit evaluation method based on AHP and SPA

    Science.gov (United States)

    Xu, Yingtao; Zhang, Ying

    2009-07-01

    Online credit evaluation is the foundation for the establishment of trust and for the management of risk between buyers and sellers in e-commerce. In this paper, a new credit evaluation method based on the analytic hierarchy process (AHP) and the set pair analysis (SPA) is presented to determine the credibility of the electronic commerce participants. It solves some of the drawbacks found in classical credit evaluation methods and broadens the scope of current approaches. Both qualitative and quantitative indicators are considered in the proposed method, then a overall credit score is achieved from the optimal perspective. In the end, a case analysis of China Garment Network is provided for illustrative purposes.

  14. Estimating Soil Organic Carbon Using VIS/NIR Spectroscopy with SVMR and SPA Methods

    Directory of Open Access Journals (Sweden)

    Xiaoting Peng

    2014-03-01

    Full Text Available With 298 heterogeneous soil samples from Yixing (Jiangsu Province, Zhongxiang and Honghu (Hubei Province, this study aimed to combine a successive projections algorithm (SPA with a support vector machine regression (SVMR model (SPA-SVMR model to improve the estimation accuracy of soil organic carbon (SOC contents using the laboratory-based visible and near-infrared (VIS/NIR, 350−2500 nm spectroscopy of soils. The effects of eight spectra pre-processing methods, i.e., Log (1/R, Log (1/R coupled with Savitzky-Golay (SG smoothing (Log (1/R + SG, first derivative with SG smoothing (FD, second derivative with SG smoothing (SD, SG, standard normal variate (SNV, mean center (MC and multiplicative scatter correction (MSC, on SPA-based informative wavelength selection were explored. The SVMR model (i.e., SVMR without SPA and SPA-PLSR model (i.e., SPA combined with partial least squares regression (PLSR were developed and compared with the SPA-SVMR model in order to evaluate the performance of SPA-SVMR. The results indicated that the variables selected by SPA and their distributions were strongly affected by different pre-processing methods, and SG was the optimal pre-processing method for SPA-SVMR model development; the SPA-SVMR model using SG pre-processing and 28 SPA-selected wavelengths obtained a better result (R2V = 0.73, RMSEV = 2.78 g∙kg−1 and RPDV = 1.89 and outperformed the SVMR model (R2V = 0.72, RMSEV = 2.83 g∙kg−1 and RPDV = 1.86 and the SPA-PLSR model (R2V = 0.62, RMSEV = 3.23 g∙kg−1 and RPDV = 1.63. Most of the spectral bands used by the SPA-SVMR model over the near-infrared region were important wavelengths for SOC content estimation. This study demonstrated that the combination of SPA and SVMR is feasible and reliable for estimating SOC content from the VIS/NIR spectra of soils in regions with multiple soil and land-use types.

  15. 75 FR 65261 - Virginia Graeme Baker Pool and Spa Safety Act; Public Accommodation

    Science.gov (United States)

    2010-10-22

    ... spa'' in relevant part as a ``swimming pool or spa that is open exclusively to patrons of a hotel or... proposed interpretive rule would interpret ``public accommodations facility'' to mean: ``An inn, hotel... accommodations facility'' as ``an inn, hotel, motel, or other place of lodging, including, but not limited to...

  16. [The basic system for the management of a spa and resort facility].

    Science.gov (United States)

    Fedotchenko, A A; Kholmogorov, N A

    2014-01-01

    The authors propose the basic system for the management of a spa and resort facility that ensures functioning of all its divisions as an integrated process. It is maintained that organization of a spa and resort facility must include measures aimed at improving its working structure, material and technical resources, marketing plans, financial management, medical services, informational support, and personnel administration.

  17. Construction, expression, functional сharacterization and practical application of fusion protein SPA-ВAPmut

    Directory of Open Access Journals (Sweden)

    Gorbatiuk O. B.

    2013-01-01

    Full Text Available Aim. The creation of genetically engineered fusion protein SPA-BAPmut and its application as a secondary immunoreagent in immunoassays. Methods. Gene cloning, PCR, electrophoresis, DNA sequencing, bacteria cells culturing, protein expression and purification, ELISA, Western-blotting were used. Results. The DNA sequences encoding Staphylococcus aureus protein A (SPA and bacterial alkaline phosphatase with enhanced catalytic activity (BAPmut were used for construction of gene encoding fusion protein SPA-BAPmut that was expressed in the high-productive Escherichia coli system and obtained in a soluble form. Cultivation conditions to provide a high-level expression of SPA-ВAPmut (> 1 g/l were determined. The target protein was obtained with purity more than 95 % using ІМАХ method. SPA-ВAPmut is thermostable, and both parts of fusion protein (SPA and BAPmut retain their IgG binding and alkaline phosphatase activity for a long time. SPA-BAPmut was used as a substitute of secondary antibodies in immunoassays. As little as 5 ng of the antigen could be detected in Western blotting and 1 g/ml of IgG in ELISA. Conclusions. The possibility of using SPA-ВAPmut as universal secondary immunoreagent for different types of immunoassays was shown.

  18. Comparing Whole-Genome Sequencing with Sanger Sequencing for spa Typing of Methicillin-Resistant Staphylococcus aureus

    DEFF Research Database (Denmark)

    Bartels, Mette Damkjaer; Petersen, Andreas; Worning, Peder

    2014-01-01

    , and an in-house analysis pipeline determines the spa types. Due to national surveillance, all MRSA isolates are sent to Statens Serum Institut, where the spa type is determined by PCR and Sanger sequencing. The purpose of this study was to evaluate the reliability of the spa types obtained by 150-bp paired......spa typing of methicillin-resistant Staphylococcus aureus (MRSA) has traditionally been done by PCR amplification and Sanger sequencing of the spa repeat region. At Hvidovre Hospital, Denmark, whole-genome sequencing (WGS) of all MRSA isolates has been performed routinely since January 2013......-end Illumina WGS. MRSA isolates from new MRSA patients in 2013 (n = 699) in the capital region of Denmark were included. We found a 97% agreement between spa types obtained by the two methods. All isolates achieved a spa type by both methods. Nineteen isolates differed in spa types by the two methods, in most...

  19. HOSPITALITY ENGLISH FOR SPA THERAPISTS IN BANYAN TREE HOTELS AND RESORTS

    Directory of Open Access Journals (Sweden)

    Ratnasari Nugraheni

    2018-04-01

    Full Text Available This study is a preliminary study of research and design for hospitality English for SPA therapist in Banyan Tree Hotels and Resorts at Bintan Island. The purpose of this study is to help the English teacher to provide a successful English training since a good English proficiency used in the hospitality industry is obliged, especially for an-international-five-star-hotel-brand. The nature of the study is qualitative using R&D approach. Since this is only a preliminary study, need analysis becomes the primary focus. The data were collected through interview and observation. The participants were people who are working in SPA department in Banyan Tree Bintan, such as SPA trainer, SPA therapist, and SPA manager.

  20. The state and perspectives of the development of spa tourism in the area of Jadar

    Directory of Open Access Journals (Sweden)

    Gajić Mirjana

    2010-01-01

    Full Text Available The paper represents an outline of the most important natural and anthropogenic tourist values on which the development of tourism of Jadar is based. It is pointed out to the most important deposits of thermomineral sources as the preconditions of the origin and development of spa centres. The largest economic effects are realized through development of health tourism in Banja Koviljaca which is the only one among spa centres that acquired the market affirmation as individual tourist motive. Banja Badanja has favorable conditions for development, still insufficiently affirmed and in shadow of far more famous Banja Koviljaca. The priorities of development of spa tourism are defined in the paper, and it is pointed to the significance of selective offer that depends on the conditions of successful organization of health spa, wellness-spa programmes and offered recreational contents.

  1. Spa therapy adjunct to pharmacotherapy is beneficial in rheumatoid arthritis: a crossover randomized controlled trial

    Science.gov (United States)

    Karagülle, Mine; Kardeş, Sinan; Dişçi, Rian; Karagülle, Müfit Zeki

    2018-02-01

    This study aims to investigate whether 2-week spa therapy, as an adjunct to usual pharmacological therapy, has any beneficial effect in patients with rheumatoid arthritis (RA). In this single-blind crossover study, 50 patients were randomly assigned in a 1:1 manner to receive usual pharmacological therapy plus 2-week spa therapy or usual pharmacological therapy alone (period 1.6 months); after a 9-month washout, patients were crossed over to the opposite assignment (period 2.6 months). Spa therapy program included a daily saline balneotherapy session at 36-37 °C for 20 min except Sundays. The clinical outcomes were evaluated at baseline, after spa therapy (2 weeks) and 3 and 6 months after the spa therapy in both period and were pain (Visual Analogue Scale (VAS)), patient and physician global assessments (VAS), Health Assessment Questionnaire (HAQ), and Disease Activity Score (DAS28). Spa therapy was superior to control therapy in improving all the assessed clinical outcomes at the end of the spa therapy. This superiority persisted significantly in physician global assessment ( p = 0.010) and with a trend in favor of spa group in patient global assessment ( p = 0.058), function ( p = 0.092), and disease activity ( p = 0.098) at 3 months. Statistically significant improvements were found in spa therapy compared to control in disease activity ( p = 0.006) and patient ( p = 0.020) and physician global ( p = 0.011) assessments, and a trend toward improvements in pain ( p = 0.069) and swollen joints ( p = 0.070) at 6 months. A 2-week spa therapy adjunct to usual pharmacological therapy provided beneficial clinical effects compared to usual pharmacological therapy alone, in RA patients treated with traditional disease-modifying antirheumatic drugs. These beneficial effects may last for 6 months.

  2. 75 FR 76038 - Zach System Corporation a Subdivision of Zambon Company, SPA Including On-Site Leased Workers of...

    Science.gov (United States)

    2010-12-07

    ... Subdivision of Zambon Company, SPA Including On-Site Leased Workers of Turner Industries and Go Johnson, La..., including on-site leased workers from Turner Industries and Go Johnson, La Porte, Texas. The Department's... investigation revealed that Zach System Corporation is a subdivision of Zambon Company, SPA, not Zach System SPA...

  3. Comparing whole-genome sequencing with Sanger sequencing for spa typing of methicillin-resistant Staphylococcus aureus.

    Science.gov (United States)

    Bartels, Mette Damkjær; Petersen, Andreas; Worning, Peder; Nielsen, Jesper Boye; Larner-Svensson, Hanna; Johansen, Helle Krogh; Andersen, Leif Percival; Jarløv, Jens Otto; Boye, Kit; Larsen, Anders Rhod; Westh, Henrik

    2014-12-01

    spa typing of methicillin-resistant Staphylococcus aureus (MRSA) has traditionally been done by PCR amplification and Sanger sequencing of the spa repeat region. At Hvidovre Hospital, Denmark, whole-genome sequencing (WGS) of all MRSA isolates has been performed routinely since January 2013, and an in-house analysis pipeline determines the spa types. Due to national surveillance, all MRSA isolates are sent to Statens Serum Institut, where the spa type is determined by PCR and Sanger sequencing. The purpose of this study was to evaluate the reliability of the spa types obtained by 150-bp paired-end Illumina WGS. MRSA isolates from new MRSA patients in 2013 (n = 699) in the capital region of Denmark were included. We found a 97% agreement between spa types obtained by the two methods. All isolates achieved a spa type by both methods. Nineteen isolates differed in spa types by the two methods, in most cases due to the lack of 24-bp repeats in the whole-genome-sequenced isolates. These related but incorrect spa types should have no consequence in outbreak investigations, since all epidemiologically linked isolates, regardless of spa type, will be included in the single nucleotide polymorphism (SNP) analysis. This will reveal the close relatedness of the spa types. In conclusion, our data show that WGS is a reliable method to determine the spa type of MRSA. Copyright © 2014, American Society for Microbiology. All Rights Reserved.

  4. [INDENA SPA company's patent portfolio of Ginkgo biloba preparation].

    Science.gov (United States)

    Wang, Nan; Guo, Kai; Cheng, Xin-min; Liu, Wei

    2015-10-01

    INDENA SPA Company in Italy is a multi-national company that produces and sells plant extracts. Based on its own re- search advantages in the field of Ginkgo biloba preparation, the company protects its own products market effectively through building patent portfolio around the patents of its opponent. Based on the multi-angle analysis for patent portfolio of G. biloba preparation from the aspects of application time, legal status, technical development route, and patent portfolio layout, this article provides technical reference on research and development of G. biloba preparation, and the author suggest that Chinese applicants learn techniques and layout experiences of other patents fully to enhance the level of research and patent protection level.

  5. COMPETITIVENESS THROUGH SUSTAINABILITY AND FINANCIAL EFFICIENCY OF SPA TOURIST DESTINATIONS

    Directory of Open Access Journals (Sweden)

    Anis Cecilia

    2010-12-01

    Full Text Available In the specific literature, success may be achieved by two important attributes: competitiveness and sustainability. Competitive advantage represents an essential criterion for surviving on the tourist market and defines the ability of one destination to use these resources effectively and in the long term. The paper work continue a study begun last year by the same authors about tourist perception of attractiveness of the two tourist SPA destinations (Buziaş and Băile Felix on a different market segment (18-35 years old people. This time, we undertake an analysis on SC Turism Felix SA in order to determine and underline the tourist competitiveness through sustainability and financial efficiency (tourism performance indicators evolution, market share, turnover, investment volume, financial returns and costs.

  6. Elementi koji diferenciraju ugovor o spašavanju od ugovora o tegljenju : (prikaz presude

    Directory of Open Access Journals (Sweden)

    Vesna Skorupan Wolff

    2016-07-01

    Full Text Available Brod kojem su se zaustavili porivni strojevi, a uslijed toga vjetar i morska struja nosili su ga prema obali, zatražio je uslugu tegljenja. Između stranaka je sporno radi li se u konkretnom slučaju o ugovoru o tegljenju ili ugovoru o spašavanju. Spašavanje je svaka djelatnosti kojoj je svrha spašavanje osoba, brodova i stvari s tih brodova. Bitan element pojma spašavanja jest da se osoba, odnosno stvar koja se spašava nalazi u opasnosti (opasnost po život osoba, odnosno propast stvari. Pod spašavanjem se podrazumijeva i pružanje pomoći. Ako je pomoć pružena tegljenjem, to ne znači da se radi o pravnom poslu tegljenja. U konkretnom slučaju u pitanju nije bio komercijalni posao tegljenja već posao spašavanja.

  7. Diverse modulation of spa transcription by cell wall active antibiotics in Staphylococcus aureus

    Directory of Open Access Journals (Sweden)

    Nielsen Lene N

    2012-08-01

    Full Text Available Abstract Background The aim of this study was to investigate the effect of various classes of clinically relevant antibiotics at sub-lethal concentrations on virulence gene expression and biofilm formation in Staphylococcus aureus. Findings LacZ promoter fusions of genes related to staphylococcal virulence were used to monitor the effects of antibiotics on gene expression in a disc diffusion assay. The selected genes were hla and spa encoding α-hemolysin and Protein A, respectively and RNAIII, the effector molecule of the agr quorum sensing system. The results were confirmed by quantitative real-time PCR. Additionally, we monitored the effect of subinhibitory concentrations of antibiotics on the ability of S. aureus to form biofilm in a microtiter plate assay. The results show that sub-lethal antibiotic concentrations diversely modulate expression of RNAIII, hla and spa. Consistently, expression of all three genes were repressed by aminoglycosides and induced by fluoroquinolones and penicillins. In contrast, the β-lactam sub-group cephalosporins enhanced expression of RNAIII and hla but diversely affected expression of spa. The compounds cefalotin, cefamandole, cefoxitin, ceftazidime and cefixine were found to up-regulate spa, while down-regulation was observed for cefuroxime, cefotaxime and cefepime. Interestingly, biofilm assays demonstrated that the spa-inducing cefalotin resulted in less biofilm formation compared to the spa-repressing cefotaxime. Conclusions We find that independently of the cephalosporin generation, cephalosporins oppositely regulate spa expression and biofilm formation. Repression of spa expression correlates with the presence of a distinct methyloxime group while induction correlates with an acidic substituted oxime group. As cephalosporines target the cell wall penicillin binding proteins we speculate that subtle differences in this interaction fine-tunes spa expression independently of agr.

  8. Sustainable Development of Spa Tourism in the Romanian West Development Region

    Directory of Open Access Journals (Sweden)

    Cipriana Sava

    2013-08-01

    Full Text Available Sustainable development of tourism includes itself in world development politics based on respect and care towards the surrounding environment. Spa tourism is one of the ancient types of tourism developed by mankind and it attracts presently more people than those who have health problems. Romania has numerous spa resorts at several levels such as local, regional, national or international ones, and they are all based on diverse tourism resources. Spa tourism is also present in the West Development Region and its revival can be attained by taking into consideration the principles of sustainable development.

  9. Tectonic and Hydrothermal Activities in Debagh, Guelma Basin (Algeria)

    OpenAIRE

    Maouche, Said; Abtout, Abdeslam; Merabet, Nacer-Eddine; Aïfa, Tahar; Lamali, Atmane; Bouyahiaoui, Boualem; Bougchiche, Sofiane; Ayache, Mohamed

    2013-01-01

    Quaternary and Pliocene travertines, deposited from hot springs, can reveal much about neotectonic and hydrothermal activity. The aim of this work is the understanding of the actual tectonic activity in the Guelma Basin and in one of its spa structures. Gravity data were collected during a field study in the Hammam Debagh (HD) area and then analyzed to better highlight the architecture of its subsurface underlying structures. This analysis was performed by means of a Bouguer anomaly, upward c...

  10. Kaks kuud Kalev SPA-s / kommenteerinud Julia Kurbat, Natalia Nazarenko-Kiivikas, Margit Lipstuhl

    Index Scriptorium Estoniae

    2012-01-01

    Kahe spordiharrastaja Kaur Sau ja Kadri Sõggeli seatud eesmärkidest 2012. aastal ja kehalisest arengust treenides kaks kuud mõnes Tallinna spordiklubis. Treeningutest Kalev Spa Hotel & Water Park'i nimekandvas spordi- ja vabaajakeskuses

  11. Encyclopaedia Entries for: (1) Spa Tourism, (2) Backpacker Tourism and (3) Country Profile: Ireland

    OpenAIRE

    Kelly, Catherine

    2017-01-01

    These entries detail definitional terms for spa tourism, backpacker tourism and an overview of tourism in the Irish Republic. Key trends, main products, visitor numbers and attractions are outlined in each concise entry for this extensive encyclopaedia.

  12. Tourism in development role of Gornja Trepča spa

    Directory of Open Access Journals (Sweden)

    Pavlović Sanja

    2008-01-01

    Full Text Available In this paper are allocated phases in tourism development in Gornja Trepča spa, signified on present and prospective kinds of tourism. Tourist traffic is analyzed from statistical references in the seventh decade of the last century to 2006. It has done comparation the number of tourists and nights in Gornja Trepča spa with spa spaces in Serbia. Accommodation facilities are showed in dependence to number of beds and contents they offer. It's analyzed preferences and demerits for tourism development in this spa settlement. It's concluded that exist good base, but it's required investments and bigger involvement of regional population in order to increase offer and demand on tourist market.

  13. spa typing and antimicrobial resistance of Staphylococcus aureus from healthy humans, pigs and dogs in Tanzania

    DEFF Research Database (Denmark)

    Katakweba, Abdul S.; Muhairwa, Amandus P.; Espinosa-Gongora, Carmen

    2016-01-01

    . aureus carrier frequencies in dogs and humans were within the expected range and low in pigs. The S. aureus spa types circulating in the community were generally not shared by different hosts and majority of types belonged to known clones. Besides ampicillin resistance, moderate levels of antimicrobial......Introduction: Staphylococcus aureus is an opportunistic pathogen causing infections in humans and animals. Here we report for the first time the prevalence of nasal carriage, spa typing and antimicrobial resistance of S. aureus in a Tanzanian livestock community. Methodology: Nasal swabs were taken....... Antimicrobial susceptibility patterns were determined by disc diffusion method. Results: S. aureus was isolated from 22 % of humans, 4 % of pigs and 11 % of dogs. A total of 21 spa types were identified: 13, 7 and 1 in human, dogs, and pigs, respectively. Three spa types (t314, t223 and t084) were shared...

  14. Radon and progeny sourced dose assessment of spa employees in balneological sites

    International Nuclear Information System (INIS)

    Kemal Uzun, Sefa; Demiroez, Isik

    2016-01-01

    This study was conducted in the scope of IAEA project with the name 'Establishing a Systematic Radioactivity Survey and Total Effective Dose Assessment in Natural Balneological Sites' (TUR/9/018), at the Health Physics department of Saraykoey Nuclear Research and Training Center (SANAEM). The aim of this study is estimation of radon and progeny sourced effective dose for the people who are working at the spa facilities by measuring radon activity concentration (RAC) at the ambient air of indoor spa pools and dressing rooms. As it is known, the source of the radon gas is the radium content of the earth crust. Therefore, thermal waters coming from ground may contain dissolved radon and the radon can diffuse water to air. So the ambient air of spa pools can contain serious RAC that depends on a lot of parameters. In this regard, RAC measurements were executed at the 70 spa facilities in Turkey. The measurements were done with both active and passive methods at ambient air of spa pools and dressing rooms. Thus, active measurements were carried out by using the Alphaguard R with diffusion mode during half an hour, and passive measurements were carried out by using the humidity resistive CR-39 radon detectors during 2 months. Results show that RAC values at ambient air of spa pools varies between 13 Bq m -3 and 10 kBq m -3 . Because long-term measurements are more reliable, if it is available, for dose calculations passive radon measurements (with CR-39 detectors) at ambient air of spa pools and dressing rooms were used, otherwise active measurement results were used. With the measurement by the conversion coefficients of ICRP 65 and occupational data of the employees has got from questionnaire forms, effective dose values were calculated. According to the calculations, spa employees are exposed to annual average dose between 0.05 and 29 mSv because of radon and progeny. (authors)

  15. Hotel Online Marketing: The Bugibba Hotel, Radisson Blu Resort Malta, St. Julian's, Preluna Hotel & SPA

    OpenAIRE

    Dinh Quynh, Mai

    2013-01-01

    The thesis covers the study of online marketing theory, a very popular trend of marketing nowadays, especially Search Engine Optimization (SEO) and Google Adwords Campaign in the analyses of the online marketing practices of three hotels from different areas and standards in Malta, namely The Bugibba Hotel, Preluna Hotel & SPA and Radisson Blu Resort Malta, St. Julian’s. From the analyses, the thesis aims at suggesting Preluna Hotel & SPA optimal online marketing practices and answering t...

  16. Potentials for development of spa tourism in region of Cer Mountain: Western Serbia

    Directory of Open Access Journals (Sweden)

    Grčić Mirko

    2006-01-01

    Full Text Available Because of their particularities, thermal and mineral springs at the foothill of Cer Mountain deserve special analysis. This is the reason we wrote this article, aiming to take reader's attention to the touristic potentials of the spa zone of Cer Mountain and possibilities for its perspective development. From the medical and excursion-recreational tourism point of view, there is a possibility for combining the spa tourism with the complementary values of Cer Mountain.

  17. Romanian spa tourism: a communist paradigm in a post communist era

    OpenAIRE

    George Erdeli; Ana Irina Dincă; Aurel Gheorghilas; Camelia Surugiu

    2011-01-01

    Spa tourism is one of the oldest forms of tourism which continuously evolved in time as the leisure industry paradigm and the consumers’ behavior changed. Similar to other countries in Central and Eastern Europe, spa tourism is an old phenomenon in Romania which expanded to the dimensions of a well defined tourism industry during the mass tourism period which also corresponded to the communism epoch. Although severely affected by the major political and socio-economic changes which occurred a...

  18. Short- and long-term effects of spa therapy in knee osteoarthritis.

    Science.gov (United States)

    Fioravanti, Antonella; Iacoponi, Francesca; Bellisai, Barbara; Cantarini, Luca; Galeazzi, Mauro

    2010-02-01

    To assess both the short- and long-term effectiveness of spa therapy in patients with primary knee osteoarthritis in a prospective, randomized, single-blinded, controlled trial. Eighty outpatients were enrolled in this study; 40 patients were treated with a combination of daily local mud packs and bicarbonate-sulfate mineral bath water from the spa center of Rapolano Terme (Siena, Italy) for 2 wks, and 40 patients continued regular, routine ambulatory care. Patients were assessed at baseline time; after 2 wks; after 3, 6, and 9 mos after the beginning of the study and were evaluated by Visual Analog Scale for spontaneous pain, Lequesne index, Western Ontario and McMaster Universities Index for gonarthrosis, Arthritis Impact Measurement Scale-1, and symptomatic drug consumption. We observed a significant improvement of all evaluated parameters at the end of the cycle of spa therapy, which persisted throughout the whole of the follow-up period, whereas in the control group no significant differences were noted. This symptomatic effect was confirmed by the significant reduction of symptomatic drug consumption. Tolerability of spa therapy seemed to be good, with light and transitory side effects. The results from our study confirm that the beneficial effects of spa therapy in patients with knee osteoarthritis lasts over time, with positive effects on the painful symptomatology and a significant improvement on functional capacities. Spa therapy can represent a useful backup to pharmacologic treatment of knee osteoarthritis or a valid alternative for patients who do not tolerate pharmacologic treatments.

  19. spa typing and antimicrobial resistance of Staphylococcus aureus from healthy humans, pigs and dogs in Tanzania.

    Science.gov (United States)

    Katakweba, Abdul Sekemani; Muhairwa, Amandus Pachificus; Espinosa-Gongora, Carmen; Guardabassi, Luca; Mtambo, Madundo M A; Olsen, John Elmerdahl

    2016-02-28

    Staphylococcus aureus is an opportunistic pathogen causing infections in humans and animals. Here we report for the first time the prevalence of nasal carriage, spa typing and antimicrobial resistance of S. aureus in a Tanzanian livestock community. Nasal swabs were taken from 100 humans, 100 pigs and 100 dogs in Morogoro Municipal. Each swab was enriched in Mueller Hinton broth with 6.5% NaCl and subcultured on chromogenic agar for S. aureus detection. Presumptive S. aureus colonies were confirmed to the species level by nuc PCR and analysed by spa typing. Antimicrobial susceptibility patterns were determined by disc diffusion method. S. aureus was isolated from 22% of humans, 4% of pigs and 11% of dogs. A total of 21 spa types were identified: 13, 7 and 1 in human, dogs, and pigs, respectively. Three spa types (t314, t223 and t084) were shared between humans and dogs. A novel spa type (t10779) was identified in an isolate recovered from a colonized human. Antimicrobials tested revealed resistance to ampicillin in all isolates, moderate resistances to other antimicrobials with tetracycline resistance being the most frequent. S. aureus carrier frequencies in dogs and humans were within the expected range and low in pigs. The S. aureus spa types circulating in the community were generally not shared by different hosts and majority of types belonged to known clones. Besides ampicillin resistance, moderate levels of antimicrobial resistance were observed irrespective of the host species from which the strains were isolated.

  20. Spa47 is an oligomerization-activated type three secretion system (T3SS) ATPase from Shigella flexneri.

    Science.gov (United States)

    Burgess, Jamie L; Jones, Heather B; Kumar, Prashant; Toth, Ronald T; Middaugh, C Russell; Antony, Edwin; Dickenson, Nicholas E

    2016-05-01

    Gram-negative pathogens often use conserved type three secretion systems (T3SS) for virulence. The Shigella type three secretion apparatus (T3SA) penetrates the host cell membrane and provides a unidirectional conduit for injection of effectors into host cells. The protein Spa47 localizes to the base of the apparatus and is speculated to be an ATPase that provides the energy for T3SA formation and secretion. Here, we developed an expression and purification protocol, producing active Spa47 and providing the first direct evidence that Spa47 is a bona fide ATPase. Additionally, size exclusion chromatography and analytical ultracentrifugation identified multiple oligomeric species of Spa47 with the largest greater than 8 fold more active for ATP hydrolysis than the monomer. An ATPase inactive Spa47 point mutant was then engineered by targeting a conserved Lysine within the predicted Walker A motif of Spa47. Interestingly, the mutant maintained a similar oligomerization pattern as active Spa47, but was unable to restore invasion phenotype when used to complement a spa47 null S. flexneri strain. Together, these results identify Spa47 as a Shigella T3SS ATPase and suggest that its activity is linked to oligomerization, perhaps as a regulatory mechanism as seen in some related pathogens. Additionally, Spa47 catalyzed ATP hydrolysis appears to be essential for host cell invasion, providing a strong platform for additional studies dissecting its role in virulence and providing an attractive target for anti-infective agents. © 2016 The Protein Society.

  1. Spa as Arena of Career Woman Resistance to Patriarch Domination

    Directory of Open Access Journals (Sweden)

    Bhernadetta Pravita Wahyuningtyas

    2011-04-01

    Full Text Available This study examines the career women who use the habit of treating the body through the routine of coming to spas, which aims to overcome the dominance of patriarchy. This study uses several concepts. First, muted group theory, which states that woman, is the one that silenced; so to overcome this condition, women should perform self-transformation. The transformation is aligned with the second concept, feminist existentialist, which defines the transformation as the change of a woman concept from Other to Self. The transformation can be achieved not only by working outside the domestic sphere, but also supported by a good appearance through a complete body treatment. Grooming habits acquired through socialization that derived in woman since their childhood. The socialization is about how women as a person who is considered weak by the world of patriarchal domination using the power of their beauty to master, subdue, and break the domination in her life. Then, with their good appearance, woman can express their existence in everything that they do from object become subject. Spa and the whole result of the activities contained in it then consciously become a way of resistance that being used by the career woman against the domination of patriarchy which overshadowing their lives. 

  2. The design of the spa - tourist recreational complex

    Directory of Open Access Journals (Sweden)

    Alenka Fikfak

    2012-01-01

    Full Text Available The study area lies in the central part of Bela Krajina in south-eastern Slovenia, between the town of Črnomelj and the border crossing at Vinica. It is situated in the vicinity of the Lahinja Landscape Park, where natural and cultural heritage sites interact in the interesting settings of preserved towns and villages. The urban planning concept developed at the workshop was based on the idea that the best space is one where the qualities of "empty spaces" and a fusion with the landscape are recognised. The concept was based on the design of a complex with several connecting structures. A green clearing was defined as the centre of activities, i.e. the core of the activity and pivot of life being the common point of all structures: it is empty, intended to allow for random connections, network organisation or spatial networking, where the key points in the built and natural structures are connected, hence representing the main communication hub between the individual structures. The concept complements the system with accommodation capacities, which are also located outside the spa complex, providing attractive accommodation in a natural setting.

  3. Spa-Wellness Center as Part of the Hotel Facility

    Directory of Open Access Journals (Sweden)

    Milica Rančić

    2013-04-01

    Full Text Available Over the last decades “wellness spa” industry has experienced a boom around the world. The word “Wellness” has been formed by merging two words: “Well Being” + “fitness”, and appeared in the thirties of the last century in the United States. The primary objective of this movement is an ancient philosophy, according to which there ́s no fulfilled life without the assent of the physical and mental, also physical and spiritual. Hotel guests, today more than ever, want higher quality offer for their money. This means that wellness is today a very important criterion by which customers select hotels. For this reason it is necessary to pay great attention to the planning, design and construction of this part of the hotel facility. The subject of this paper is wellness and spa centers as part of the hotel facility. The task is to investigate and analyze elements of this space, to determine spatial areas of wellness center, as well as their relationships and spatial organization, in order to reach the goal - getting useful guidelines for planning quality wellness center. To all of this could be achieved, we must first go back to distant history where dating back the beginnings of wellness.

  4. Spa Services In Hotel Facilities In The Lublin Province The Importance Of Hotel Facilities In The Provision Of Spa Services In The Lublin Province

    Directory of Open Access Journals (Sweden)

    Świeca Andrzej

    2015-06-01

    Full Text Available Introduction. Apart from basic services, the modern hotel industry provides a number of additional services, including those having to do with wellness. This article attempts to provide a general description of spa services in selected hotel facilities in the Lublin Province in Poland.

  5. [Knee osteoarthritis and SPA therapy: assessment of joint function and quality of life].

    Science.gov (United States)

    Costantino, M; Filippelli, A

    2011-01-01

    In industrialized countries the increase in life expectancy of the population has led to an increase in chronic diseases such as osteoarthritis (OA). Knee osteoarthritis for the high disability and psychological stress, not considered adequately, has negative impact on the quality of life. In this pathology SPA therapy, in particular the sulphur mud-bath therapy, can provide a stage of the therapeutic strategy. However, studies on the impact of SPA therapy on the quality of life in knee osteoarthritis are insufficient. The aim research was to evaluate the effectiveness of SPA therapy on chronic pain, joint function and psychological distress that characterize knee osteoarthritis. The study has been performed on 44 subjects affected by knee Osteoarthritis, being 27 (61%) women and 17 (39%) men (mean age: 58±8.7 years, age range: 42-76 years). The investigated subjects were treated with a cycle of a combination of daily locally applied mud-packs and bicarbonate-sulphurous mineral bath water from Terme of Telese SpA (Benevento-Italy). At the beginning and at the end of the Spa therapy was evaluated the level of pain (using VAS scale), the degree of knee flexion (using goniometer), the level of anxiety and depression (using SDS Zung Test and SAS Zung test) and the impact of sulphurous mud-bath treatment on quality of life (using the algofunctional Lequesne indice). At the end of Spa therapy the results of our study have shown a significant (plife. The data from this investigation seem to indicate that the SPA therapy may be useful in improving joint function and quality of life in knee osteoarthritis.

  6. Sequence-based spa typing as a rapid screening method for the areal and nosocomial outbreaks of MRSA.

    Science.gov (United States)

    Narukawa, Munetoshi; Yasuoka, Akira; Note, Ryougo; Funada, Hisashi

    2009-07-01

    Methicillin-resistant Staphylococcus aureus (MRSA) is the leading cause of nosocomial infection and MRSA outbreaks have become a major problem. Therefore, the rapid and accurate typing of MRSA isolates is important for epidemiological surveys and nosocomial infection control. Pulsed-field gel electrophoresis (PFGE) is considered as the gold standard technique for MRSA typing, because of its high discriminatory power, but its procedure is rather complicated and time-consuming. The spa gene encodes a cell wall component of Staphylococcus aureus protein A, and exhibits polymorphism. Sequencing the spa gene is expected superior to PFGE in speed and data interpretation. In the present study, we evaluated whether spa typing of MRSA is useful for nosocomial outbreak analysis and epidemiological investigations. We analyzed 19 nosocomial outbreak isolates from 4 separate hospitals and 26 isolates from outpatients of Toyama University Hospital. Either PFGE or spa typing revealed a single nosocomial strain that appears unique to each hospital. Indeed, spa typing confirmed the four different strains, but PFGE demonstrated only 3 strains. With the total 45 isolates, PFGE showed 16 different patterns and spa typing showed 12 patterns. Moreover, we were able to analyze the spa gene in about 2 days, from sampling to obtaining the results, whereas it took about 7 days with PFGE. In conclusion, sequence-based spa typing shows comparable sensitivities to PFGE, and is a rapid and easy handling method. The sequence-based spa typing can be used as the rapid screening test when MRSA outbreak is suspected in areas and hospitals.

  7. Development opportunities for spa tourism in Vâlcea Subcarpathians: Towards a single European market

    Directory of Open Access Journals (Sweden)

    Ana-Maria Roanghes–Mureanu

    2014-11-01

    Full Text Available Nowadays tourism has undoubtedly become essential to both national and international economies and each country is currently trying to face the challenges imposed by this industry. In this respect, Romania has introduced a new range of treatments in the spa tourism field which proved to be therapeutic for a significant number of patients. The article aims to assess the feasibility of spa tourism in Vâlcii Subcarpathians offering a clear analysis of the evolution of the material and technical base of the resort. Therefore, the study focused on the evaluation of both natural and man-made resources favourable to the emergence and development of the spa resorts from Vâlcea County, Romania. At the same time, the authors gave it a touch of originality by shaping the development perspectives of Vâlcea Subcarpathian region. The research has a solid theoretical background based on relevant papers and fundamental studies in spa tourism meant to offer a significant overview of the subject. The main results are based on a survey which was conducted in order to determine the quality degree of the accommodation and treatment in the region under study as well as the accessibility of the population to such services. At the same time, the paper outlines the main weaknesses and opportunities regarding the activities of spa tourism in Vâlcea Subcarpathians as a starting point for a further development strategy.

  8. Analysis of the radioactivity in the 'Elguea' spa, Villa Clara, Cuba

    International Nuclear Information System (INIS)

    Fernandez G, I.M.; Zerquera, J.T.; Carrazana G, J.; Capote F, E.; Rodriguez C, G.

    2006-01-01

    The 'Elguea' spa, located in the north coast of the county of Villa Clara, Cuba, is considered one of those more important spas of Latin America. The waters of this spa are rich in salts of chlorine, sodium, bromine, sulfides and its contain radon. As a result of measurements of environmental gamma dose rates carried out in the area of the spa, its were considered levels of dose between 0.13 and 2.3 mSv. The obtained results motivated that it was carried out a characterization, from the radiological point of view, of the spa. This characterization is of supreme importance to be able to evaluate the impact that it has and the discharges of its waters on the environment, as well as, those dose that the population potentially affected can receive by these discharges. With this end its were carried out quantitative determinations of those existent natural more significant radionuclides in different environmental objects coming from the area of the spa and its surroundings, as well as one characterization gamma 'in situ' of the same one. The obtained results are present in this work. (Author)

  9. The blue light-induced interaction of cryptochrome 1 with COP1 requires SPA proteins during Arabidopsis light signaling.

    Science.gov (United States)

    Holtkotte, Xu; Ponnu, Jathish; Ahmad, Margaret; Hoecker, Ute

    2017-10-01

    Plants constantly adjust their growth, development and metabolism to the ambient light environment. Blue light is sensed by the Arabidopsis photoreceptors CRY1 and CRY2 which subsequently initiate light signal transduction by repressing the COP1/SPA E3 ubiquitin ligase. While the interaction between cryptochromes and SPA is blue light-dependent, it was proposed that CRY1 interacts with COP1 constitutively, i.e. also in darkness. Here, our in vivo co-immunoprecipitation experiments suggest that CRY1 and CRY2 form a complex with COP1 only after seedlings were exposed to blue light. No association between COP1 and CRY1 or CRY2 was observed in dark-grown seedlings. Thus, our results suggest that cryptochromes bind the COP1/SPA complex after photoactivation by blue light. In a spa quadruple mutant that is devoid of all four SPA proteins, CRY1 and COP1 did not interact in vivo, neither in dark-grown nor in blue light-grown seedlings. Hence, SPA proteins are required for the high-affinity interaction between CRY1 and COP1 in blue light. Yeast three-hybrid experiments also show that SPA1 enhances the CRY1-COP1 interaction. The coiled-coil domain of SPA1 which is responsible for COP1-binding was necessary to mediate a CRY1-SPA1 interaction in vivo, implying that-in turn-COP1 may be necessary for a CRY1-SPA1 complex formation. Hence, SPA1 and COP1 may act cooperatively in recognizing and binding photoactivated CRY1. In contrast, the blue light-induced association between CRY2 and COP1 was not dependent on SPA proteins in vivo. Similarly, ΔCC-SPA1 interacted with CRY2, though with a much lower affinity than wild-type SPA1. In total, our results demonstrate that CRY1 and CRY2 strongly differ in their blue light-induced interaction with the COP1/SPA complex.

  10. Market segment of families with children: a new stimulus for modern Czech spa industry?

    Directory of Open Access Journals (Sweden)

    Darina Jelínková

    2017-06-01

    Full Text Available The paper deals with a comprehensive range of hotel services for families with children at spa facilities of the Czech Republic, in line with current trends and requirements of this market segment. The main goal of this paper is to determine the preferences, needs and requirements of families with children in terms of amenities and services offer at spa hotels designated specifically for this target group. The secondary goal is to determine the current state of hotel services and facilities of Czech First Class hotels, which are the holders of the Baby Friendly Certificate. Subsequently, service offerings of these spa hotels are compared with the existing range of services for families with children in the selected Czech spas. In conclusion, based on the information obtained from the analyses and marketing research, a solution of the services portfolio intended for the market segment of families with children is recommended here using marketing mix as applied to tourism.

  11. Romanian spa tourism: a communist paradigm in a post communist era

    Directory of Open Access Journals (Sweden)

    George Erdeli

    2011-11-01

    Full Text Available Spa tourism is one of the oldest forms of tourism which continuously evolved in time as the leisure industry paradigm and the consumers’ behavior changed. Similar to other countries in Central and Eastern Europe, spa tourism is an old phenomenon in Romania which expanded to the dimensions of a well defined tourism industry during the mass tourism period which also corresponded to the communism epoch. Although severely affected by the major political and socio-economic changes which occurred after the Revolution in 1989, this industry coexists with new emergent forms of tourism orienting, itself towards new dimensions embraced by the contemporary leisure consumerism (e.g. medical tourism, cosmetic treatments. Lying on considerable balneal and climate resources and displaying an important communist heritage both in physical terms (large and massive tourism structures and in virtual and psychological terms (social supportive ticket granting system, Romanian spa tourism faces various challenges in the attempt to adapt in a new tourism era.

  12. CONCEPTUALIZATION AND CLASSIFICATION OF BALNEO, SPA AND WELLNESS ESTABLISHMENTS IN BULGARIA

    Directory of Open Access Journals (Sweden)

    Maria Trifonova Vasileva

    2010-12-01

    Full Text Available This paper analyzes the origin, the process of development and consolidation of the health, SPA and wellness tourism in different regions of the world as well as in Bulgaria. Special attention is paid to the etymology of the words “wellness” and “SPA”, used as a basis for differentiation of their structural elements as tourism segments. Under observations are some theoretical issues, including the significant need of term clarification of these forms of tourism. Other matters of high importance comprise of the classification of health, spa and wellness resorts, the vocational training of managerial and executive staff and etc. Based on the conducted research and analysis some recommendations are made in the aim to the further development of health, spa and wellness tourism.

  13. SpaRibs Geometry Parameterization for Wings with Multiple Sections using Single Design

    Science.gov (United States)

    De, Shuvodeep; Jrad, Mohamed; Locatelli, Davide; Kapania, Rakesh K.; Baker, Myles; Pak, Chan-Gi

    2017-01-01

    The SpaRibs topology of an aircraft wing has a significant effect on its structural behavior and stability as well as the flutter performance. The development of additive manufacturing techniques like Electron Beam Free Form Fabrication (EBF3) has made it feasible to manufacture aircraft wings with curvilinear spars, ribs (SpaRibs) and stiffeners. In this article a new global-local optimization framework for wing with multiple sections using curvilinear SpaRibs is described. A single design space is used to parameterize the SpaRibs geometry. This method has been implemented using MSC-PATRAN to create a broad range of SpaRibs topologies using limited number of parameters. It ensures C0 and C1 continuities in SpaRibs geometry at the junction of two wing sections with airfoil thickness gradient discontinuity as well as mesh continuity between all structural components. This method is advantageous in complex multi-disciplinary optimization due to its potential to reduce the number of design variables. For the global-local optimization the local panels are generated by an algorithm which is totally based on a set algebra on the connectivity matrix data. The great advantage of this method is that it is completely independent of the coordinates of the nodes of the finite element model. It is also independent of the order in which the elements are distributed in the FEM. The code is verified by optimizing of the CRM Baseline model at trim condition at Mach number equal to 0.85 for five different angle of attack (-2deg, 0deg,2deg,4deg and 6deg). The final weight of the wing is 19,090.61 lb. This value is comparable to that obtained by Qiang et al. 6 (19,269 lb).

  14. Streptococcus mutans SpaP binds to RadD of Fusobacterium nucleatum ssp. polymorphum.

    Science.gov (United States)

    Guo, Lihong; Shokeen, Bhumika; He, Xuesong; Shi, Wenyuan; Lux, Renate

    2017-10-01

    Adhesin-mediated bacterial interspecies interactions are important elements in oral biofilm formation. They often occur on a species-specific level, which could determine health or disease association of a biofilm community. Among the key players involved in these processes are the ubiquitous fusobacteria that have been recognized for their ability to interact with numerous different binding partners. Fusobacterial interactions with Streptococcus mutans, an important oral cariogenic pathogen, have previously been described but most studies focused on binding to non-mutans streptococci and specific cognate adhesin pairs remain to be identified. Here, we demonstrated differential binding of oral fusobacteria to S. mutans. Screening of existing mutant derivatives indicated SpaP as the major S. mutans adhesin specific for binding to Fusobacterium nucleatum ssp. polymorphum but none of the other oral fusobacteria tested. We inactivated RadD, a known adhesin of F. nucleatum ssp. nucleatum for interaction with a number of gram-positive species, in F. nucleatum ssp. polymorphum and used a Lactococcus lactis heterologous SpaP expression system to demonstrate SpaP interaction with RadD of F. nucleatum ssp. polymorphum. This is a novel function for SpaP, which has mainly been characterized as an adhesin for binding to host proteins including salivary glycoproteins. In conclusion, we describe an additional role for SpaP as adhesin in interspecies adherence with RadD-SpaP as the interacting adhesin pair for binding between S. mutans and F. nucleatum ssp. polymorphum. Furthermore, S. mutans attachment to oral fusobacteria appears to involve species- and subspecies-dependent adhesin interactions. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  15. Low Cost Quasi Binary Weighting Addition Log-SPA LDPC Decoders

    OpenAIRE

    Po-Hui Yang; Ming-Yu Lin

    2013-01-01

    This paper proposes a new addition method, which can be applied to reduce the hardware cost of LDPC decoders using log-SPA, which traditionally has the best lowest bit error rate (BER) but the highest hardware requirement. The proposed quasi-binary weighting addition can be simply implemented by OR gates. With auxiliary pseudo-carry circuit, the BER performance can reach a fair level. In the log-SPA message-passing path, numeric transform reduction architecture is proposed for further hardwar...

  16. [Mechanism of strategic management of a sanatorium-and-spa facility under current economic conditions].

    Science.gov (United States)

    Kholmogorov, N A; Fedotchenko, A A

    2010-01-01

    The existing system of management of sanatorium-and-spa facilities constitutes a major economic risk factor under current socio-economic situation. One of the most important conditions for the sustainable continuation of activities of a sanatorium-and-spa institution is its adaptability to the changing economic environment. Those health care providers are likely to have an advantage in new conditions that offer a larger scope of specialized services, simultaneously reduces their costs and prices, introduce resource-saving technologies, and stimulate motivation of the medical personnel.

  17. Contributions to the knowledge and capitalization of spa potential for tourism: Băile Buziaș resort.

    Directory of Open Access Journals (Sweden)

    IRINA CÎRCIUMARU

    2017-05-01

    Full Text Available Romania is a country that has rich spa resources that consist of natural healing factors, scattered over the entire country: mineral and thermal waters, mud and therapeutic gases, lakes and therapeutic salt. Spa tourism resources generated since antiquity the oldest and most characteristic form of tourism in Romania - health tourism. Spa sector is one of the six elements (called health and wellness within the national touristic brand. Băile Buziaş is one of the oldest spa in Romania, known in Roman times as the Centum Putei [4]. Due to favorable natural conditions, with rich mineral springs and a mild climate, Buziaş may be the "spa pearl" of Banat, framing the resort in a strategy to exploit the spa potential, which is a necessity that needs to be solved rapidly. Strategy construction is realized using strategic questions: What are our resources? How can we improve the spa resort? How can we develop a spa product? What are the promotion techniques of this product on the Romania’ resort market and abroad?

  18. Molecular analysis of virulent genes (coa and spa) of staphylococcus aureus involved in natural cases of bovine mastitis

    International Nuclear Information System (INIS)

    Khan, A.; Javed, M.T.; Mahmood, F.; Hussain, R.

    2013-01-01

    The present study was undertaken to determine the distribution and genotypic characteristics of Staphylococcus aureus isolates recovered from naturally occurring mastitis in cattle and buffaloes. For this purpose a total of 1445 lactating cattle (653) and buffaloes (792) present at two experimental livestock farms Okara (Bahadarnagar) and Sahiwal (Qadiarabad), in and around district Faisalabad and slaughtered at an abattoir due to low milk yield and were screened for mastitis. California Mastitis Test (CMT) was used to detect sub clinical mastitis. The positive quarter milk samples were collected for culturing of S. aureus isolates. taphylococcus aureus isolates were identified on the basis of growth features, biochemical characteristics, coagulase test and as well as amplification of coagulase (coa) and spa (spa-X) genes specific to its virulence. S. aureus isolates (n=265) were characterized by Polymerase chain reaction to determine the frequency of coagulase (coa) and spa (spa-X) genes. From these isolates the amplification of the coagulase (coa) gene yielded three different PCR products approximately 204bp to 490bp while spa (spa-X) gene produced five different products ranging in size from 190bp to 320bp. PCR revealed that from all the coagulase positive S. aureus isolates 261(98.5%) had spa (spa-X) gene. The results of the present study indicated that S. aureus isolates recovered from bovine mastitis were genetically different within and among the various herds which may provide essential and valuable strategies to control staphylococcal infections in future. (author)

  19. [Measurement of soil organic matter and available K based on SPA-LS-SVM].

    Science.gov (United States)

    Zhang, Hai-Liang; Liu, Xue-Mei; He, Yong

    2014-05-01

    Visible and short wave infrared spectroscopy (Vis/SW-NIRS) was investigated in the present study for measurement of soil organic matter (OM) and available potassium (K). Four types of pretreatments including smoothing, SNV, MSC and SG smoothing+first derivative were adopted to eliminate the system noises and external disturbances. Then partial least squares regression (PLSR) and least squares-support vector machine (LS-SVM) models were implemented for calibration models. The LS-SVM model was built by using characteristic wavelength based on successive projections algorithm (SPA). Simultaneously, the performance of LSSVM models was compared with PLSR models. The results indicated that LS-SVM models using characteristic wavelength as inputs based on SPA outperformed PLSR models. The optimal SPA-LS-SVM models were achieved, and the correlation coefficient (r), and RMSEP were 0. 860 2 and 2. 98 for OM and 0. 730 5 and 15. 78 for K, respectively. The results indicated that visible and short wave near infrared spectroscopy (Vis/SW-NIRS) (325 approximately 1 075 nm) combined with LS-SVM based on SPA could be utilized as a precision method for the determination of soil properties.

  20. Thompson’s Spa: The Most Famous Lunch Counter in the World

    Directory of Open Access Journals (Sweden)

    Peter Szende

    2012-09-01

    Full Text Available Thompson’s Spa in Boston was one of the most celebrated restaurant companies in America at the turn of the twentieth century. Founder Charles Eaton was a pioneer in production and service methods, who developed a variety of innovative mechanical systems. This article describes the founding, growth, and eventual decline of the company during the period 1882 to 1968.

  1. 78 FR 68357 - Airworthiness Directives; Aermacchi S.p.A. Airplanes

    Science.gov (United States)

    2013-11-14

    ..., contact Alenia Aermacchi S.p.A, Via Paola Foresio, 1, 21040 Venegono Superiore (Varese)--Italy; telephone... comments. We specifically invite comments on the overall regulatory, economic, environmental, and energy...)--Italy; telephone: 0331-813111; fax: 0331-827595; Internet: http://www.aleniaaermacchi.it/en-US/Pages...

  2. 77 FR 27144 - Airworthiness Directives; Agusta S.p.A. Helicopters

    Science.gov (United States)

    2012-05-09

    ... Agusta, S.p.A., Via Giovanni Agusta 520, 21017 Cascina Costa di Samarate (VA), Italy, ATTN: Giovanni... written comments, data, or views. We also invite comments relating to the economic, environmental, energy.... Discussion The European Aviation Safety Agency (EASA), which is the Technical Agent for Italy, a Member State...

  3. Exposure to radon in the radon spa Niška Banja, Serbia

    International Nuclear Information System (INIS)

    Nikolov, J.; Todorovic, N.; Petrovic Pantic, T.; Forkapic, S.; Mrdja, D.; Bikit, I.; Krmar, M.; Veskovic, M.

    2012-01-01

    There is a well-known radon spa Niška Banja in south-east of Serbia. In Niška Banja spa there is a medical complex and radon is used for therapeutic purposes for many different diseases. This paper presents elevated radon levels in the Niška Banja spa. Indoor radon and radon in water activity concentration measurements in thermal pools and therapy rooms are presented. There are also results from gamma spectrometry measurements of soil, rock and therapy mud. A special attention is paid to the medical staff exposure to radon around thermal pools. The annual effective doses from radon for staff working around the thermal pools in Niška Banja spa are very high comparing to the maximum recommendation level. The maximal radon concentration of (22.90 ± 0.57) kBq m −3 was measured in the basement of the hotel-dispensary “Radon”. This hotel is settled on “bigar” rock – travertine, which has high content of 226 Ra.

  4. Structure of Spa15, a type III secretion chaperone from Shigella flexneri with broad specificity

    NARCIS (Netherlands)

    Eerde, André van; Hamiaux, Cyril; Pérez, Javier; Parsot, Claude; Dijkstra, Bauke W.

    2004-01-01

    Type III secretion (TTS) systems are used by many Gram-negative pathogens to inject virulence proteins into the cells of their hosts. Several of these virulence effectors require TTS chaperones that maintain them in a secretion-competent state. Whereas most chaperones bind only one effector, Spa15

  5. 75 FR 12167 - Virginia Graeme Baker Pool and Spa Safety Act; Public Accommodation

    Science.gov (United States)

    2010-03-15

    ... pool or spa that is ``open exclusively to patrons of a hotel or other public accommodations facility... Web site at http://www.cpsc.gov . B. Legal Analysis In adopting a reasonable interpretation of... ``an inn, hotel, motel, or other place of lodging, except for an establishment located within a...

  6. Combined spa-exercise therapy is effective in patients with ankylosing spondylitis: a randomized controlled trial

    NARCIS (Netherlands)

    van Tubergen, A.; Landewé, R.; van der Heijde, D.; Hidding, A.; Wolter, N.; Asscher, M.; Falkenbach, A.; Genth, E.; Thè, H. G.; van der Linden, S.

    2001-01-01

    To determine the efficacy of combined spa-exercise therapy in addition to standard treatment with drugs and weekly group physical therapy in patients with ankylosing spondylitis (AS). A total of 120 Dutch outpatients with AS were randomly allocated into 3 groups of 40 patients each. Group 1 (mean

  7. 76 FR 62605 - Virginia Graeme Baker Pool and Spa Safety Act; Interpretation of Unblockable Drain

    Science.gov (United States)

    2011-10-11

    ... 19, 2008. The VGB Act's purpose is to prevent suction entrapment by swimming pool and spa drains and child drowning in swimming pools and spas. Section 1404(c)(1)(A)(i) of the VGB Act requires that each... area (beyond the shadowed portion) cannot create a suction force in excess of the removal force values...

  8. Radioactivity measurements and risk assessments of spa waters in some areas in Turkey.

    Science.gov (United States)

    Duran, Selcen Uzun; Kucukomeroglu, Belgin; Damla, Nevzat; Taskin, Halim; Celik, Necati; Cevik, Uğur; Ersoy, Hakan

    2017-03-01

    The current study presents the results of the activity of radionuclides in spa waters, and evaluates their radiological influences on the population consuming these waters in the Central and Eastern Black Sea regions of Turkey. Since these waters are used for therapy and consumption purposes unconsciously, their radiological impact on the people was computed by taking into consideration the annual intake through ingestion of 226 Ra, 232 Th, 40 K, 137 Cs and 222 Rn. The mean activities were estimated to be 11.35 for gross alpha, 6.23 for gross beta, 2.96 for 226 Ra, 0.42 for 232 Th, 0.069 for 137 Cs, 0.19 for 40 K, and 267 Bq L -1 for 222 Rn, respectively. The estimated effective doses from spa water were found to be 49.77 µSv a -1 ( 226 Ra), 5.95 µSv a -1 ( 232 Th), 0.07 µSv a -1 ( 137 Cs), 0.83 µSv a -1 ( 40 K) and 56.03 µSv a -1 ( 222 Rn). These values were evaluated and compared with related verified values from literature. Also, physico-chemical characterizations of spa water samples considered in the current study were investigated. This study would be useful for consumers and official authorities for the assessment of radiation exposure risk due to usage of the considered spa waters.

  9. ANALISIS KINERJA KARYAWAN DI THE VILLAS BALI HOTEL AND SPA KUTA, BADUNG

    Directory of Open Access Journals (Sweden)

    A.A. Ayu Sriathi

    2012-11-01

    Full Text Available Improvement the performance of employee is give positive impact incorporate goal, therefore management has to learn attitude and behaviouremployee in corporate. There are some factor which influence for performancean employee, amongst those level stress of employee and industrial'srelationship. Thing such it, The Villas Bali Hotel and Spa, one of lodging firm atKuta, Badung, that getting assimilates to outrival by effort a sort also noticestress and industrial relationship in effort increases employee performance.This research was aimed to find out how the influences of stress andindustrial’s relationship and variable which that influential largest for theemployee performance of The Villas Bali Hotel and Spa, Kuta, Badung. Toanswer that, therefore done by research where all employee which is 84 personare made as respondent. Hereafter the data analysis consisting of validity andreliability of research instrument (quitionare, classic assuming test, andmultiple regression analysis (simultant and partial testBased on analysis result is gotten that stress and industrial's relationshipin simultant and also partially effect, having for significant for employeeperformance of The Villas Bali Hotel and Spa Kuta, Badung. Industrial'srelationship having for greater influence for employee performance of The VillasBali Hotel and Spa Kuta, Badung.

  10. LHC suppliers win Golden Hadron awards : Sandro Ferraris and Guiseppi Ginola from Simic SpA

    CERN Multimedia

    Maximilien Brice

    2004-01-01

    Simic SpA (Italy) received its award for manufacturing the vacuum vessels for the superconducting dipoles. The 937 blue cylinders manufactured by Simic will provide the thermal insulation for the magnets. Measuring 15 metres in length and 1 metre in diameter, they are designed to withstand a vacuum of 10-4 Pa.

  11. Objectification of a Choice of a Spa Treatment Plan for Arthritis of the Hip Joint

    Czech Academy of Sciences Publication Activity Database

    Och, F.; Medonos, J.; Hanzlíček, P.; Valenta, Zdeněk; Dvořák, V.; Zvárová, Jana

    2013-01-01

    Roč. 1, č. 1 (2013), s. 10-10 ISSN 1805-8698. [EFMI 2013 Special Topic Conference. 17.04.2013-19.04.2013, Prague] Institutional support: RVO:67985807 Keywords : decision-support * spa treatment * hip arthritis * statistical analysis Subject RIV: IN - Informatics, Computer Science

  12. SPA (Solus per Aqua) service industry: An entrepeneurship opportunity to beauty education department

    Science.gov (United States)

    Marwiyah, Apriyani, Delta

    2018-03-01

    Beauty industry grows vastly in the scope of regional, national, or international. Beauty industry includes Spa service. It becomes one of the choices where the urban citizen can use it to release their stress and relax their mind. This business grows as the development of technology. Spa industry should be able to provide the best service for physical and mental therapy, it will make the user of the service can be freed from their business and stress in the respective time to be healthies, more beautiful, and able to do their activity maximally. Spa treatment consists of hair creambath, facial treatment, manicure-pedicure, scrub treatment, foot spa, aromatherapy, and body treatment with traditional cosmetics which are easy to get in Indonesia. Beauty education is one of the programs in Home Economics Department of Engineering Faculty of UNNES. This program was established to produce graduates in beauty fields as Vocational High School teachers with bachelor (S1) qualification. The graduates suppose to be excellent, professional, skillful, and care to the environment, culture, and social condition around them. It prepares them as teachers of beauty (in formal and non- formal education). Besides, it also prepared them to have professional competence in production fields of beauty service with adaptive, creative, and innovative which can be entrepreneurs who are able to create job vacancies for others. Beauty education used KKNI- based curriculum, which is oriented to Industry and Working Fields with UNNES' Conservation basis. It provided the students a chance to practive their knowledge in working internship program, study field trip, and teaching practice program. The industry of Spa service provides a big chance to become an entrepreneur, create a working field, and help the government reduce unemployment number, whether from beauty education graduates or from vocational high school students

  13. SP-A binds alpha1-antitrypsin in vitro and reduces the association rate constant for neutrophil elastase

    Directory of Open Access Journals (Sweden)

    Carrabino Natalia

    2005-12-01

    Full Text Available Abstract Background α1-antitrypsin and surfactant protein-A (SP-A are major lung defense proteins. With the hypothesis that SP-A could bind α1-antitrypsin, we designed a series of in vitro experiments aimed at investigating the nature and consequences of such an interaction. Methods and results At an α1-antitrypsin:SP-A molar ratio of 1:1, the interaction resulted in a calcium-dependent decrease of 84.6% in the association rate constant of α1-antitrypsin for neutrophil elastase. The findings were similar when SP-A was coupled with the Z variant of α1-antitrypsin. The carbohydrate recognition domain of SP-A appeared to be a major determinant of the interaction, by recognizing α1-antitrypsin carbohydrate chains. However, binding of SP-A carbohydrate chains to the α1-antitrypsin amino acid backbone and interaction between carbohydrates of both proteins are also possible. Gel filtration chromatography and turnover per inactivation experiments indicated that one part of SP-A binds several molar parts of α1-antitrypsin. Conclusion We conclude that the binding of SP-A to α1-antitrypsin results in a decrease of the inhibition of neutrophil elastase. This interaction could have potential implications in the physiologic regulation of α1-antitrypsin activity, in the pathogenesis of pulmonary emphysema, and in the defense against infectious agents.

  14. Epithelial Adhesion Mediated by Pilin SpaC Is Required for Lactobacillus rhamnosus GG-Induced Cellular Responses

    Science.gov (United States)

    Ardita, Courtney S.; Mercante, Jeffrey W.; Kwon, Young Man; Luo, Liping; Crawford, Madelyn E.; Powell, Domonica N.; Jones, Rheinallt M.

    2014-01-01

    Lactobacillus rhamnosus GG is a widely used probiotic, and the strain's salutary effects on the intestine have been extensively documented. We previously reported that strain GG can modulate inflammatory signaling, as well as epithelial migration and proliferation, by activating NADPH oxidase 1-catalyzed generation of reactive oxygen species (ROS). However, how strain GG induces these responses is unknown. Here, we report that strain GG's probiotic benefits are dependent on the bacterial-epithelial interaction mediated by the SpaC pilin subunit. By comparing strain GG to an isogenic mutant that lacks SpaC (strain GGΩspaC), we establish that SpaC is necessary for strain GG to adhere to gut mucosa, that SpaC contributes to strain GG-induced epithelial generation of ROS, and that SpaC plays a role in strain GG's capacity to stimulate extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) signaling in enterocytes. In addition, we show that SpaC is required for strain GG-mediated stimulation of cell proliferation and protection against radiologically inflicted intestinal injury. The identification of a critical surface protein required for strain GG to mediate its probiotic influence advances our understanding of the molecular basis for the symbiotic relationship between some commensal bacteria of the gut lumen and enterocytes. Further insights into this relationship are critical for the development of novel approaches to treat intestinal diseases. PMID:24928883

  15. Epithelial adhesion mediated by pilin SpaC is required for Lactobacillus rhamnosus GG-induced cellular responses.

    Science.gov (United States)

    Ardita, Courtney S; Mercante, Jeffrey W; Kwon, Young Man; Luo, Liping; Crawford, Madelyn E; Powell, Domonica N; Jones, Rheinallt M; Neish, Andrew S

    2014-08-01

    Lactobacillus rhamnosus GG is a widely used probiotic, and the strain's salutary effects on the intestine have been extensively documented. We previously reported that strain GG can modulate inflammatory signaling, as well as epithelial migration and proliferation, by activating NADPH oxidase 1-catalyzed generation of reactive oxygen species (ROS). However, how strain GG induces these responses is unknown. Here, we report that strain GG's probiotic benefits are dependent on the bacterial-epithelial interaction mediated by the SpaC pilin subunit. By comparing strain GG to an isogenic mutant that lacks SpaC (strain GGΩspaC), we establish that SpaC is necessary for strain GG to adhere to gut mucosa, that SpaC contributes to strain GG-induced epithelial generation of ROS, and that SpaC plays a role in strain GG's capacity to stimulate extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) signaling in enterocytes. In addition, we show that SpaC is required for strain GG-mediated stimulation of cell proliferation and protection against radiologically inflicted intestinal injury. The identification of a critical surface protein required for strain GG to mediate its probiotic influence advances our understanding of the molecular basis for the symbiotic relationship between some commensal bacteria of the gut lumen and enterocytes. Further insights into this relationship are critical for the development of novel approaches to treat intestinal diseases. Copyright © 2014, American Society for Microbiology. All Rights Reserved.

  16. Sensitivity Test of Parameters Influencing Flood Hydrograph Routing with a Diffusion-Wave Distributed using Distributed Hydrological Model, Wet Spa, in Ziarat Watershed

    Directory of Open Access Journals (Sweden)

    narges javidan

    2017-02-01

    Full Text Available Introduction: Flood routing is a procedure to calculate flood stage and water depth along a river or to estimate flood hydrograph at river downstream or at reservoir outlets using the upstream hydrography . In river basins, excess rainfall is routed to the basin outlet using flow routing techniques to generate flow hydrograph. A GIS-based distributed hydrological model, Wet Spa, has been under development suitable for flood prediction and watershed management on a catchment scale. The model predicts outflow hydrographs at the basin outlet or at any converging point in the watershed, and it does so in a user-specified time step. The model is physically based, spatially distributed and time-continuous, and simulates hydrological processes of precipitation, snowmelt, interception, depression, surface runoff, infiltration, evapotranspiration, percolation, interflow, groundwater flow, etc. continuously both in time and space, for which the water and energy balance are maintained on each raster cell. Surface runoff is produced using a modified coefficient method based on the cellular characteristics of slope, land use, and soil type, and allowed to vary with soil moisture, rainfall intensity and storm duration. Interflow is computed based on the Darcy’s law and the kinematic approximation as a function of the effective hydraulic conductivity and the hydraulic gradient, while groundwater flow is estimated with a linear reservoir method on a small subcatchment scale as a function of groundwater storage and a recession coefficient. Special emphasis is given to the overland flow and channel flow routing using the method of linear diffusive wave approximation, which is capable to predict flow discharge at any converging point downstream by a unit response function. The model accounts for spatially distributed hydrological and geophysical characteristics of the catchment. Determination of the river flow hydrograph is a main target in hydrology

  17. (Dahomey) Basin

    African Journals Online (AJOL)

    Timothy Ademakinwa

    13 km maximum width in the onshore at the basin axis along Nigerian and Republic of Benin boundary. This narrows westwards and eastwards to about 5 km (Coker and Ejedawe, 1987; Coker,. 2002). Detailed geology, evolution, stratigraphy and hydrocarbon occurrence of the basin have been described by Jones and ...

  18. The economic impact of wellness tourism with a focus on the spa industry in the Czech Republic

    OpenAIRE

    Smrčka, Pavel

    2016-01-01

    This master thesis aims to provide a complex up-to-date overview of the spa industry in the Czech Republic and to analyze the position of Spa Luhačovice. Having shown the growing global importance of wellness tourism, the focus moves onto the spa industry which plays a major role in wellness. Nevertheless,the medical significance of spas can't be overlooked, especially in the Czech Republic where spas are known for the quality of medical care. While statistical reports from the Health Informa...

  19. Arabidopsis cryptochrome 1 interacts with SPA1 to suppress COP1 activity in response to blue light

    Science.gov (United States)

    Liu, Bin; Zuo, Zecheng; Liu, Hongtao; Liu, Xuanming; Lin, Chentao

    2011-01-01

    Plant photoreceptors mediate light suppression of the E3 ubiquitin ligase COP1 (CONSTITUTIVE PHOTOMORPHOGENIC 1) to affect gene expression and photomorphogenesis. However, how photoreceptors mediate light regulation of COP1 activity remains unknown. We report here that Arabidopsis blue-light receptor cryptochrome 1 (CRY1) undergoes blue-light-dependent interaction with the COP1-interacting protein SPA1 (SUPPRESSOR OF PHYTOCHROME A). We further show that the CRY1–SPA1 interaction suppresses the SPA1–COP1 interaction and COP1-dependent degradation of the transcription factor HY5. These results are consistent with a hypothesis that photoexcited CRY1 interacts with SPA1 to modulate COP1 activity and plant development. PMID:21511871

  20. [The topical problems of pediatric balneotherapy and the spa and health resort-based treatment of the children].

    Science.gov (United States)

    Razumov, A N; Khan, M A

    2016-01-01

    This article is devoted to the topical problems of pediatric balneotherapy with special reference to the organization of the spa and health resort-based treatment of the children in the Russian Federation. The main issues discussed by the authors include the current state of health resort care for the children, the problem of statutory regulation of the activities of the children's spa and health resort facilities, the approaches to increasing the availability of the spa and health resort-based treatment for the children at the enhanced risk of the development of chronic diseases, disabilities, and tuberculosis. Also considered are the problems of the development of the regulatory framework for the medical rehabilitation of the children based at the spa and health resort facilities. The principal goals to be sought in climatotherapy, physiotherapy, balneotherapy, and pelotherapy in the pediatric context are outlined along with the further prospects for the development of the main areas of pediatric balneology.

  1. Analysis of the acoustic climate of a spa park using the fuzzy set theory

    Science.gov (United States)

    Sztubecka, Małgorzata; Sztubecki, Jacek

    2016-11-01

    The paper describes the differences between the actual results of the measurement of equivalent sound level and the feelings of people visiting "a Spa Park". Noise, as one of the environmental pollutants, cause detrimental effects on the recipient. Measurements of noise are usually performed in urban areas, especially in the road environments, providing a basis for measures to limit their impact on the environment. Often in the measurement there are ignored areas for recreation. Usually, they do not determine the relationship between the results of measurements of noise equivalent sound level and the individual feelings of the people living in these areas. The analysis was performed with the use of fuzzy set theory. The evaluation of the acoustic climate on the "Spa Park" should be determined on the basis of sound level measurements and questionnaires.

  2. Clinical researches on the efficacy of spa therapy in fibromyalgia: a systematic review

    Directory of Open Access Journals (Sweden)

    Antonio Fraioli

    2013-06-01

    Full Text Available BACKGROUND: Fibromyalgia is characterized by chronic widespread pain, tenderness at muscle and tendon insertions point when digital pressure is applied, sleep disorders, chronic fatigue, depressive episodes, anxiety, and other functional somatic syndromes. OBJECTIVE: The aim of this study was to determine whether balneotherapy with mineral waters and mineral-water containing mud is effective in the management of fibromyalgia. METHODS: We conducted a systematic review of the literature regarding spa therapy in the treatment of the fibromyalgia. We searched many databases for articles published between 2000 and 2012 and we selected 7 studies among 65 articles retrieved. A total of 142 patients received balneotherapy and 129 were controls. CONCLUSIONS: Study data confirms that spa therapy could improve the symptoms of fibromyalgia including pain, depression and minor symptoms.

  3. The paradigm of territoriality in the spa tourism: The concept of spatial indicators

    Directory of Open Access Journals (Sweden)

    Dželebdžić Omiljena

    2010-01-01

    Full Text Available The famous tradition of spa places like cultural centers and health resorts with unique potential in natural curing springs could be a solid, but not an adequate, ground for their development according to the challenges of contemporary society. The renewed interest in the territorial aspects of tourism as a response to globalization enhanced the influence of spatial factor (tourismscape on current on tourism demand. The network of flows, relationships and interactions, as the core of the territoriality concept, is not something new and unknown in regional planning but requires a new analytical tool for researching the global network connectivity. This paper analyzes the concept of territorial networking in the system of physical, functional and organizational networks as one of the crucial aspects in the development of well balanced tourism region. The consideration aim is to examine and define the relevant indicators that may specify the level of competitiveness of spa region in the global tourism market.

  4. Diverse modulation of spa transcription by cell wall active antibiotics in Staphylococcus aureus

    DEFF Research Database (Denmark)

    Nielsen, Lene Nørby; Roggenbuck, Michael; Haaber, Jakob Krause

    2012-01-01

    ABSTRACT: BACKGROUND: The aim of this study was to investigate the effect of various classes of clinically relevant antibiotics at sub-lethal concentrations on virulence gene expression and biofilm formation in Staphylococcus aureus. FINDINGS: LacZ promoter fusions of genes related...... to staphylococcal virulence were used to monitor the effects of antibiotics on gene expression in a disc diffusion assay. The selected genes were hla and spa encoding alpha-hemolysin and Protein A, respectively and RNAIII, the effector molecule of the agr quorum sensing system. The results were confirmed...... by quantitative real-time PCR. Additionally, we monitored the effect of subinhibitory concentrations of antibiotics on the ability of S. aureus to form biofilm in a microtiter plate assay. The results show that sub-lethal antibiotic concentrations diversely modulate expression of RNAIII, hla and spa. Consistently...

  5. [Certain medico-economic prerequisites for the integration of spa and resort facilities into the system of compulsory health insurance].

    Science.gov (United States)

    Artem'eva, G B; Gekht, I A

    2013-01-01

    The involvement of spa and resort facilities in the system of compulsory health insurance is of primary importance for the improvement of medical aid provided to the population. The application of the methods for the calculation of differential expenditures on the spa and resort-based treatment and estimation of their dependence on a variety of factors may facilitate the more rational use of the available resources of compulsory health insurance.

  6. Analysis of the acoustic climate of a spa park using the fuzzy set theory

    OpenAIRE

    Sztubecka Małgorzata; Sztubecki Jacek

    2016-01-01

    The paper describes the differences between the actual results of the measurement of equivalent sound level and the feelings of people visiting "a Spa Park". Noise, as one of the environmental pollutants, cause detrimental effects on the recipient. Measurements of noise are usually performed in urban areas, especially in the road environments, providing a basis for measures to limit their impact on the environment. Often in the measurement there are ignored areas for r...

  7. DNAGear--a free software for spa type identification in Staphylococcus aureus.

    Science.gov (United States)

    AL-Tam, Faroq; Brunel, Anne-Sophie; Bouzinbi, Nicolas; Corne, Philippe; Bañuls, Anne-Laure; Shahbazkia, Hamid Reza

    2012-11-19

    Staphylococcus aureus is both human commensal and an important human pathogen, responsible for community-acquired and nosocomial infections ranging from superficial wound infections to invasive infections, such as osteomyelitis, bacteremia and endocarditis, pneumonia or toxin shock syndrome with a mortality rate up to 40%. S. aureus reveals a high genetic polymorphism and detecting the genotypes is extremely useful to manage and prevent possible outbreaks and to understand the route of infection. One of current and expanded typing method is based on the X region of the spa gene composed of a succession of repeats of 21 to 27 bp. More than 10000 types are known. Extracting the repeats is impossible by hand and needs a dedicated software. Unfortunately the only software on the market is a commercial program from Ridom. This article presents DNAGear, a free and open source software with a user friendly interface written all in Java on top of NetBeans Platform to perform spa typing, detecting new repeats and new spa types and synchronizing automatically the files with the open access database. The installation is easy and the application is platform independent. In fact, the SPA identification is a formal regular expression matching problem and the results are 100% exact. As the program is using Java embedded modules written over string manipulation of well established algorithms, the exactitude of the solution is perfectly established. DNAGear is able to identify the types of the S. aureus sequences and detect both new types and repeats. Comparing to manual processing, which is time consuming and error prone, this application saves a lot of time and effort and gives very reliable results. Additionally, the users do not need to prepare the forward-reverse sequences manually, or even by using additional tools. They can simply create them in DNAGear and perform the typing task. In short, researchers who do not have commercial software will benefit a lot from this

  8. Molecular characterization of Staphylococcus aureus isolates from southwest of Iran using spa and SCCmec typing methods.

    Science.gov (United States)

    Darban-Sarokhalil, Davood; Khoramrooz, Seyed Sajjad; Marashifard, Masoud; Malek Hosseini, Seyed Ali Asghar; Parhizgari, Najmeh; Yazdanpanah, Mahboobeh; Gharibpour, Farzaneh; Mirzaii, Mehdi; Sharifi, Bahman; Haeili, Mehri

    2016-09-01

    Staphylococcus aureus remains a major cause of nosocomial infection worldwide. Characterization of S. aureus isolates circulating in the southwest of Iran will contribute to understand and control the spread of the strains in this area. spa and SCCmec typing methods were used for genotyping of 125 S. aureus isolates obtained from two teaching hospitals in Ahvaz. Drug susceptibility testing was performed by using disk diffusion method. Frequency of the methicillin resistant S. aureus (MRSA) isolates was 39% (n = 34) and 27% (n = 10) in Emam Khomeini and Golestan hospitals, respectively. Except for Erythromycin, MRSA strains showed high rate of resistance to antimicrobial agents including penicillin (100%), norfloxacine (80%), azitromycin (80%), ciprofloxacin (80%), gentamycin (77%), cotrimoxazole (75%), cephotaxime. All isolates were sensitive to vancomycin. Out of 44 MRSA strains, 39 (88.5%) were SCCmec III, three (7%) were IVc and two (4.5%) of them were nontypeable. spa types t037 (26 isolates; 59%), and t1149 (25 isolates; 31%) were the most dominant types found in MRSA and methicillin sensitive S. aureus (MSSA) strains, respectively. We found SCCmec type III as the most prominent type indicating that most of the studied bacterial population had hospital origin. spa type t037, the most frequent genotype in this study were significantly (100%) associated with MRSA. For the first time we are reporting spa types t692, t706 and t018 from Iran and t342, t704, t2622, t5598, t11270 and t2864 from Asia. Moreover we are reporting types t6871 and t2684 for the second time in the world. Copyright © 2016. Published by Elsevier Ltd.

  9. Tourism of Krapinske Toplice Spa - present position and possibilities of Its development

    Directory of Open Access Journals (Sweden)

    Martina Jakovčić

    2003-01-01

    Full Text Available This paper presents present state of development of tourism in Krapinske Toplice Spa and possibilities of further development from the geographical point of view. Natural, socio-economical, cultural and historical components of the area are analysed. Special attention is given to development of health tourism and its impact on the development of other types of tourism. Paper explains the main reason of slower tourist development of Krapinske Toplice in comparison to other spas in the region.

  10. Determination of protective properties of Bardejovske Kuple spa curative waters by rotational viscometry and ABTS assay

    Directory of Open Access Journals (Sweden)

    TOPOLSKA Dominika

    2014-02-01

    Full Text Available Mineral waters from Bardejovske Kupele spa are natural, strongly mineralized, with healing effects. They are classified as hydrocarbonic - containing chloride and sodium - carbonic, cold, hypotonic, with a relatively high boric acid content. Potential anti-oxidative effects of curative waters from Bardejovske Kupele were investigated against the hyaluronan (HA degradation. High-molar-mass HA was exposed to the action of ascorbate and cupric ions, which initiate free-radical chain degradation. Time-dependent changes of dynamic viscosity (h of the HA solutions were monitored by rotational viscometry. The radical scavenging capacity of curative waters was determined by the ABTS assay. Despite a significantly high content of transition metal ions, especially iron, remarkable protective effects of the two curative spa waters were found, namely Alzbeta and Klara. Even though “Alzbeta´s“ iron content was 3.5-fold higher than “Klara´s“, “Alzbeta“ was shown to have better protective properties against the HA degradation compared to “Klara“. Bolus addition of ferric ions to the reaction system instead of the natural iron-containing curative water caused a significant HA degradation. The ABTS decolorization assay revealed that the curative spa waters were proven as poorly effective scavengers of the ABTS·+ cation radical.

  11. The efficacy of SPA0355 in protecting ? cells in isolated pancreatic islets and in a murine experimental model of type 1 diabetes

    OpenAIRE

    Bae, Ui-Jin; Song, Mi-Young; Jang, Hyun-Young; Jin Gim, Hyo; Ryu, Jae-Ha; Lee, Sang-Myeong; Jeon, Raok; Park, Byung-Hyun

    2013-01-01

    Cytokines activate several inflammatory signals that mediate ?-cell destruction. We recently determined that SPA0355 is a strong anti-inflammatory compound, thus reporting its efficacy in protecting ? cells from various insults. The effects of SPA0355 on ?-cell survival were studied in RINm5F cells and primary islets. The protective effects of this compound on the development of type 1 diabetes were evaluated in non-obese diabetic (NOD) mice. SPA0355 completely prevented cytokine-induced nitr...

  12. Purification, crystallization and preliminary X-ray diffraction analysis of SpaD, a backbone-pilin subunit encoded by the fimbrial spaFED operon in Lactobacillus rhamnosus GG.

    Science.gov (United States)

    Chaurasia, Priyanka; von Ossowski, Ingemar; Palva, Airi; Krishnan, Vengadesan

    2015-01-01

    SpaD is the predicted backbone-pilin subunit of the SpaFED pilus, whose loci are encoded by the fimbrial spaFED operon in Lactobacillus rhamnosus GG, a Gram-positive gut-adapted commensal strain with perceived probiotic benefits. In this study, soluble recombinant SpaD protein was overproduced in Escherichia coli and then purified by Ni2+-chelating affinity and gel-filtration chromatography. After limited proteolysis with α-chymotrypsin, good-quality crystals of SpaD were obtained which diffracted beyond 2.0 Å resolution. These crystals belonged to the orthorhombic space group P2(1)2(1)2(1), with unit-cell parameters a=50.11, b=83.27, c=149.65 Å. For phasing, sodium iodide-derivatized crystals were prepared using the halide quick-soaking method and diffraction data were collected in-house to a resolution of 2.2 Å. An interpretable electron-density map was successfully obtained using single-wavelength anomalous diffraction (SAD).

  13. Characterisation of Shigella Spa33 and Thermotoga FliM/N reveals a new model for C-ring assembly in T3SS.

    Science.gov (United States)

    McDowell, Melanie A; Marcoux, Julien; McVicker, Gareth; Johnson, Steven; Fong, Yu Hang; Stevens, Rebecca; Bowman, Lesley A H; Degiacomi, Matteo T; Yan, Jun; Wise, Adam; Friede, Miriam E; Benesch, Justin L P; Deane, Janet E; Tang, Christoph M; Robinson, Carol V; Lea, Susan M

    2016-02-01

    Flagellar type III secretion systems (T3SS) contain an essential cytoplasmic-ring (C-ring) largely composed of two proteins FliM and FliN, whereas an analogous substructure for the closely related non-flagellar (NF) T3SS has not been observed in situ. We show that the spa33 gene encoding the putative NF-T3SS C-ring component in Shigella flexneri is alternatively translated to produce both full-length (Spa33-FL) and a short variant (Spa33-C), with both required for secretion. They associate in a 1:2 complex (Spa33-FL/C2) that further oligomerises into elongated arrays in vitro. The structure of Spa33-C2 and identification of an unexpected intramolecular pseudodimer in Spa33-FL reveal a molecular model for their higher order assembly within NF-T3SS. Spa33-FL and Spa33-C are identified as functional counterparts of a FliM-FliN fusion and free FliN respectively. Furthermore, we show that Thermotoga maritima FliM and FliN form a 1:3 complex structurally equivalent to Spa33-FL/C2 , allowing us to propose a unified model for C-ring assembly by NF-T3SS and flagellar-T3SS. © 2015 The Authors. Molecular Microbiology published by John Wiley & Sons Ltd.

  14. Characterisation of Shigella Spa33 and Thermotoga FliM/N reveals a new model for C‐ring assembly in T3SS

    Science.gov (United States)

    McDowell, Melanie A.; Marcoux, Julien; McVicker, Gareth; Johnson, Steven; Fong, Yu Hang; Stevens, Rebecca; Bowman, Lesley A. H.; Degiacomi, Matteo T.; Yan, Jun; Wise, Adam; Friede, Miriam E.; Benesch, Justin L. P.; Deane, Janet E.; Tang, Christoph M.; Robinson, Carol V.

    2015-01-01

    Summary Flagellar type III secretion systems (T3SS) contain an essential cytoplasmic‐ring (C‐ring) largely composed of two proteins FliM and FliN, whereas an analogous substructure for the closely related non‐flagellar (NF) T3SS has not been observed in situ. We show that the spa33 gene encoding the putative NF‐T3SS C‐ring component in S higella flexneri is alternatively translated to produce both full‐length (Spa33‐FL) and a short variant (Spa33‐C), with both required for secretion. They associate in a 1:2 complex (Spa33‐FL/C2) that further oligomerises into elongated arrays in vitro. The structure of Spa33‐C 2 and identification of an unexpected intramolecular pseudodimer in Spa33‐FL reveal a molecular model for their higher order assembly within NF‐T3SS. Spa33‐FL and Spa33‐C are identified as functional counterparts of a FliM–FliN fusion and free FliN respectively. Furthermore, we show that T hermotoga maritima  FliM and FliN form a 1:3 complex structurally equivalent to Spa33‐FL/C2, allowing us to propose a unified model for C‐ring assembly by NF‐T3SS and flagellar‐T3SS. PMID:26538516

  15. Science goals and expected results from the smart-1 amie multi-coulour micro-camera

    Science.gov (United States)

    Josset, J.-L.; AMIE Team

    2003-04-01

    The Advanced Moon micro-Imager Experiment (AMIE), which will be on board ESA SMART-1, the first European mission to the Moon (launch foreseen in 2003), is an imaging system with scientific, technical and public outreach oriented objectives. The science objectives are to image the Lunar South Pole (Aitken basin), permanent shadow areas (ice deposit), eternal light (crater rims), ancient Lunar Nonmare volcanism, local spectro-photometry and physical state of the lunar surface, and to map high latitudes regions (south) mainly at far side. The main science goals and the expected results from the AMIE multi-colour micro-camera are presented.

  16. Mechanisms of action of spa therapies in rheumatic diseases: what scientific evidence is there?

    Science.gov (United States)

    Fioravanti, Antonella; Cantarini, Luca; Guidelli, Giacomo Maria; Galeazzi, Mauro

    2011-01-01

    Spa therapy represents a popular treatment for many rheumatic diseases. The mechanisms by which immersion in mineral or thermal water or the application of mud alleviates suffering in rheumatic diseases are not fully understood. The net benefit is probably the result of a combination of factors, with mechanical, thermal and chemical effects among the most prominent ones. Buoyancy, immersion, resistance and temperature all play important roles. According to the gate theory, pain relief may be due to the pressure and temperature of the water on skin; hot stimuli may influence muscle tone and pain intensity, helping to reduce muscle spasm and to increase the pain threshold. Mud-bath therapy increases plasma β-endorphin levels and secretion of corticotrophin, cortisol, growth hormone and prolactin. It has recently been demonstrated that thermal mud-pack therapy induces a reduction in the circulating levels of prostaglandin E2 (PGE2), leukotriene B4 (LTB4), interleukin-1β (IL-1β) and tumour necrosis factor-α (TNF-α), important mediators of inflammation and pain. Spa therapy has been found to cause an increase in insulin-like growth factor-1 (IGF1), which stimulates cartilage metabolism, and transforming growth factor-β (TGF-β). There is also evidence of the positive action of mud-packs and thermal baths on the oxidant/antioxidant system, with a reduction in the release of reactive oxygen (ROS) and nitrogen (RNS) species. Overall, thermal stress has an immunosuppressive effect. Many other non-specific factors may also contribute to the beneficial effects observed after spa therapy in some rheumatic diseases, including effects on cardiovascular risk factors, and changes in the environment, pleasant surroundings and the absence of work duties.

  17. Outbreak of Legionnaires' disease among cruise ship passengers exposed to a contaminated whirlpool spa.

    Science.gov (United States)

    Jernigan, D B; Hofmann, J; Cetron, M S; Genese, C A; Nuorti, J P; Fields, B S; Benson, R F; Carter, R J; Edelstein, P H; Guerrero, I C; Paul, S M; Lipman, H B; Breiman, R

    1996-02-24

    Outbreaks of travel-related Legionnaires' disease present a public-health challenge since rapid, sensitive, and specific diagnostic tests are not widely used and because detection of clusters of disease among travellers is difficult. We report an outbreak of Legionnaires' disease among cruise ship passengers that occurred in April, 1994, but that went unrecognised until July, 1994. After rapid diagnosis of Legionnaires' disease in three passengers by urine antigen testing, we searched for additional cases of either confirmed (laboratory evidence of infection) or probable Legionnaires' disease (pneumonia of undetermined cause). A case-control study was conducted to compare exposures and activities on the ship and in ports of call between each case-passenger and two or three matched control-passengers. Water samples from the ship, from sites on Bermuda, and from the ship's water source in New York City were cultured for legionellae and examined with PCR. 50 passengers with Legionnaires' disease (16 confirmed, 34 probable) were identified from nine cruises embarking between April 30 and July 9, 1994. Exposure to whirlpool spas was strongly associated with disease (odds ratio 16.2, 95% Cl 2.8-351:7); risk of acquiring Legionnaires' disease increased by 64% (95% Cl 12-140) for every hour spent in the spa water. Passengers spending time around the whirlpool spas, but not in the water, were also significantly more likely to have acquired infection. Legionella pneumophila serogroup 1 was isolated only from the sand filter in the ship's whirlpool spa. This isolate matched a clinical isolate from the respiratory secretions of a case-passenger as judged by monoclonal antibody subtyping and by arbitrarily primed PCR. This investigation shows the benefit of obtaining a recent travel history, the usefulness or urine antigen testing for rapid diagnosis of legionella infection, and the need for improved surveillance for travel-related Legionnaires' disease. New strategies for

  18. Rehabilitation of patients with rheumatoid arthritis treated in stationary spa treatment

    Directory of Open Access Journals (Sweden)

    Amila Jaganjac

    2015-04-01

    Full Text Available Introduction: Rheumatic diseases are nonsurgical diseases of the locomotor system and connective tissue. Rheumatoid arthritis (RA is a systemic inflammatory disease of connective tissue of unknown cause, with progressive chronic or subacute course. The aim of the research is to determine whether stationary spa treatment leads to improvement of the functional status in patients with rheumatoid arthritis. Methods: We included 35 patients with diagnosis of rheumatoid arthritis, referred for treatment at the spa " Ilidža " Gradačac from February to April 2014. Patients not adhering to treatment protocols were excluded. We used Visual analogue pain scale (VAS, HAQ questionnaire and assessment of the clinical condition before and after the treatment based on the scores 1-5.Results: There were 32 female and 3 male patients. The average age was 62.28±8.31 years. Based on the HAQ, 12 patients had no difficulties, 9 of them perform activities with little difficulties, 10 with many difficulties, and 4 patients cannot perform certain activities. Before treatment VAS was 6.63±2.36, and after treatment the 2.51±2.27. Ratings of clinical condition before treatment was 2.38±0.74, and after the treatment 3.64±0.98. The most frequently used therapies were kinesitherapy, magnetotherapy and interferential electricity. Conclusions: Stationary treatment at the spa „Ilidža“ Gradačac leads to an improvement of the functional status in patients with rheumatoid arthritis.

  19. Performance of scintillation proximity assay (SPA) to measure the level of VEGFR 1 protein

    Energy Technology Data Exchange (ETDEWEB)

    LEE, So-Young; LIM, Jae-Cheong; KIM, Jin-Joo [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2014-10-15

    Scintillation proximity assay is a one of radioimmunoassay and can be assayed without the washing or filtration procedures normally used to separate bound from free fractions. Due to its simplicity and high-throughput protocol, it is broadly applicable to immunology, receptor binding, monitoring receptor-ligand interactions and enzyme reactions. Briefly, an antibody or receptor is coated on SPA beads. When a radiolabeled antigen or ligand binds to the beads, the SPA beads stimulate to emit short range electrons. The {sup 3}H and {sup 125}I are commonly used for radiolabeling and the produced photons are detectable with a liquid scintillation counter (LSC). A binding affinity of unlabeled ligands can be determined by competitive reaction of the radiolabeled ligands. Bevacizumab is a recombinant humanized monoclonal antibody, and can stop or delay growth of tumors by inhibiting vascular endothelial growth factor (VEGF). Bevacizumab was approved by FDA for metastatic cancer such as colorectal cancers, ovarian cancers, breast cancers and glioblastoma multiform of the brain. Recently, Dan G. duda et al. was reported that the concentration of vascular endothelial growth factor receptor-1 (VEGFR-1) in plasma may potentially be used as a negative selection biomarker. In this study, we describe a method using scintillation proximity assay to detect the amounts of VEGFR-1 protein. This method is successfully used to measure the concentration of VEGFR-1 protein in human cell extracts. In summary, a simple and sensitive assay is developed for measuring the amount of VEGFR 1 protein in cancer cell lysate using SPA beads. The antibody coating on the beads and antigen binding are achieved in one mixing step.

  20. spa type distribution in Staphylococcus aureus originating from pigs, cattle and poultry

    DEFF Research Database (Denmark)

    Hasman, Henrik; Moodley, A.; Guardabassi, L.

    2010-01-01

    Methicillin-resistant S. aureus (MRSA) of clonal complex 398 (CC398) is emerging globally among production animals such as cattle, pigs and poultry as well as among humans. However, little is known about the prevalence of CC398 among methicillin sensitive S. aureus (MSSA) or the relative clonal...... distribution of S. aureus isolated from these three animal reservoirs. To study this, we have analyzed a random sample of S. aureus consisting of 296 epidemiologically unrelated isolates from infections and colonisation of pigs, cattle and poultry. These were examined and compared by spa and multi...

  1. Plan Estratégico de Marketing aplicado a la Empresa Studio Morena Nail&Spa

    OpenAIRE

    Delgado Gomezcoello, Carlos Javier

    2013-01-01

    El presente trabajo de investigación tiene como objetivo la elaboración de Plan estratégico de marketing aplicado a la empresa Studio Morena Nail & Spa, en cuyo contenido se delinearan en forma pragmática, coherente y objetiva, conceptos de pensamiento estratégico, análisis del entorno, variables mercadológicas y herramientas administrativas que coadyuven a la diferenciación con otras empresas que presten servicios similares en el mercado. Magister en Administración de Empresas

  2. Binding of human collectins (SP-A and MBP) to influenza virus.

    OpenAIRE

    Malhotra, R; Haurum, J S; Thiel, S; Sim, R B

    1994-01-01

    Collectins are a group of soluble proteins each of which has collagenous domains and non-collagenous globular domains, the latter containing the consensus residues found in C-type lectins. Members of the collectin family are the serum proteins mannan-binding protein (MBP), conglutinin, CL-43, and the lung-associated proteins surfactant protein A (SP-A) and surfactant protein D (SP-D). MBP and conglutinin have been shown previously to bind to influenza viruses and to inhibit the infectivity an...

  3. Effects of balneotherapy and spa therapy on levels of cortisol as a stress biomarker: a systematic review

    Science.gov (United States)

    Antonelli, Michele; Donelli, Davide

    2018-02-01

    Balneotherapy and spa therapy are well-known practices, even though limited evidence has been produced about their biological effects. This systematic review primarily aims at assessing if balneotherapy, mud/peloid therapy, and spa therapy may influence cortisol levels. Secondarily, it aims at understanding if these interventions may improve stress resilience. PubMed/Medline, Embase, and Cochrane Library were searched for relevant articles in English or Italian about studies involving healthy and sub-healthy subjects or patients with a diagnosed disease about effects of balneotherapy, mud/peloid therapy, and spa therapy on serum and salivary cortisol levels. Fifteen studies involving 684 subjects were included. Five studies investigated biological effects of balneotherapy alone. Two of them reported significant changes of cortisol levels in healthy participants. The other three studies reported no significant variations in patients with rheumatic conditions. No studies investigated biological effects of mud/peloid therapy alone. Ten studies investigated biological effects of spa therapy with or without included mud/peloid therapy, and in all but two studies, significant variations of cortisol levels were reported. Our main findings suggest that balneotherapy may have the potential to influence cortisol levels in healthy subjects, in such a way as to improve stress resilience. Spa therapy with or without included mud/peloid therapy demonstrated the same potential to influence cortisol levels also in sub-healthy subjects and in patients with a diagnosed disease. Therefore, balneotherapy and spa therapy may be considered as useful interventions for the management of stress conditions. Further investigation is needed because of limited available data.

  4. THE INFLUENCE OF CROSS-TRAINING DUE TO SPA TREATMENT IN CURRING FUNCTIONAL NEUROTIC DISORDERS

    Directory of Open Access Journals (Sweden)

    Rade Stefanović

    2006-06-01

    Full Text Available Modern civilization moves to endless automation and mechanization. This fact, in one hand, has positive effect on increase of life standard, but also carries its own risks and threats of mankind. Axelberg, famous academician, makes an interesting remark that only a hundred years ago man did 96 % of his work by himself, while today most manufacturing processes are 100% automated. Stress, lack of physical activity and bad food regime are canses of organic damages of cardiopulmonary system. Latest research, conducted in many countries, shows that for proper functioning of every organism the minimum of moving is necessary.Term neurosis was introduced in medical literature by Scottish doctor W. Cullen in 1777. By that term were considered different clinical appearances which are believed neurotic todey, but also the phenomena today considered as psychosomatic disorders of character and behavior. Pavlov’s reflexive theory is basic in treatment of some types of neurossis’ during spa treatments in Nerečinska Banja. It usually starts at the beginning of May and ends in October, but sometimes if weather is nice, it can last until the middle of November. The treatment cure last tventy-one day, doesn’t include medicaments, but only spa water, baths and massage.

  5. Principles of bioclimatic architecture applied at the project of spa center at Stara Planina mountain

    Directory of Open Access Journals (Sweden)

    Marić Igor

    2011-01-01

    Full Text Available Application of bioclimatic parameters in the design of tourist objects is an important factor for reducing energy consumption and preserving the environment. It represents the response to constant changing of climate conditions. Given the fact that development of tourism has negative consequences on the environment, it is necessary to examine the way design process can affect the reduction of energy and environmental pollution. This paper analyzes the principles of bioclimatic planning and design of the Spa Center at the Balkan Mountain that is one of the most valuable ecosystems in Serbia. Adaptation to the existing climate change was analyzed on two levels. The first level was urban factors that include analysis of local climate and environment that affect the positioning of the object and preliminary form. The second level was architecture factors with technical and technological solutions that can be achieved through the application of climate and energy responsible designing. Final analyses indicate that the bioclimatic approach is necessary in the initial stage of setting preliminary design for the building, because later it would take more effort to install technology that requires time and the whole process makes much more expensive. The work indicates that the energy needs of optimized Spa center like represented, from the very beginning of planning and designing, can be drastically reduced.

  6. Characterization of Si(112) and In/Si(112) studied by SPA-LEED

    Energy Technology Data Exchange (ETDEWEB)

    Hoecker, Jan; Speckmann, Moritz; Schmidt, Thomas; Falta, Jens [Institute of Solid State Physics, University of Bremen, 28359 Bremen (Germany)

    2010-07-01

    High index surfaces are of strong interest in todays research because of the possibility to grow low dimensional structures. It has for instance already been shown that the adsorption of Ga can induce the formation of 1D metal chains on Si(112) (cf. Snijders et al., PRB 72, 2005). In this work we investigated the clean Si(112) surface and the adsorption of In on Si(112) to establish an analogy to Ga/Si(112) using spot profile analyzing low energy electron diffraction (SPA-LEED). By means of reciprocal space mapping we determined the bare Si(112) surface to be decomposed into alternating (5512) and (111) facets in [1 anti 10] direction with (2 x 1) and (7 x 7) reconstruction, respectively (cf. Baski et al., Surf. Sci. 392, 1997). With SPA-LEED we were able to observe the decreasing intensity of the facet spots in-situ while depositing In on Si(112) and thus reveal the smoothening of the surface due to the deposition of In. At saturation coverage we found a (3.x1) reconstruction, where x is dependent on the deposition temperature and changes from x=7 at 400 C to x=5 at 500 C. This leads us to the assumption that the reconstruction is not incommensurate but a mixture of (3 x 1) and (4 x 1) building blocks, which is very similar to the super structure of Ga on Si(112).

  7. Residual basins

    International Nuclear Information System (INIS)

    D'Elboux, C.V.; Paiva, I.B.

    1980-01-01

    Exploration for uranium carried out over a major portion of the Rio Grande do Sul Shield has revealed a number of small residual basins developed along glacially eroded channels of pre-Permian age. Mineralization of uranium occurs in two distinct sedimentary units. The lower unit consists of rhythmites overlain by a sequence of black shales, siltstones and coal seams, while the upper one is dominated by sandstones of probable fluvial origin. (Author) [pt

  8. A park on new land ? transformations in the spatial arrangement of the SPA Park in Świnoujście

    OpenAIRE

    Bożena Łukasik

    2016-01-01

    An unusual history of the Spa Park in Świnoujście is closely related to the town his­tory, its strategic location and development of the spa function. Since the beginning the spatial arrangement of the park has been undergoing changes in its structure and area. The aim of this study was to determine the stages of development of the park and factors affecting changes in its spatial arrangement. As a result of the investigations, four stages in the development of the park composition were i...

  9. Evaluation on Cost Overrun Risks of Long-distance Water Diversion Project Based on SPA-IAHP Method

    Science.gov (United States)

    Yuanyue, Yang; Huimin, Li

    2018-02-01

    Large investment, long route, many change orders and etc. are main causes for costs overrun of long-distance water diversion project. This paper, based on existing research, builds a full-process cost overrun risk evaluation index system for water diversion project, apply SPA-IAHP method to set up cost overrun risk evaluation mode, calculate and rank weight of every risk evaluation indexes. Finally, the cost overrun risks are comprehensively evaluated by calculating linkage measure, and comprehensive risk level is acquired. SPA-IAHP method can accurately evaluate risks, and the reliability is high. By case calculation and verification, it can provide valid cost overrun decision making information to construction companies.

  10. Radiological impact of a spent fuel disposal in a deep geological granite formation - results of the european spa project

    International Nuclear Information System (INIS)

    Baudoin, P.; Gay, D.; Certes, C.; Serres, C.

    2000-01-01

    The SPA project (Spent fuel disposal Performance Assessment) is the latest of four integrated performance assessment exercises on nuclear waste disposal in geological formations, carried out in the framework of the European Community 'Nuclear Fission' Research Programmes. The SPA project, which was undertaken by ENRESA, GRS, IPSN, NRG, SCK.CEN and VTT between May 1996 and April 1999, was devoted to the study of disposal of spent fuel in various host rock formations (clay, crystalline rocks and salt formation). This project is a direct continuation of the efforts made by the European Community since 1982 to build a common understanding of the methods applicable to deep disposal performance assessment. (authors)

  11. [On the development of a system of medical weather forecast for the Caucasian Mineral Waters spa-and-resort complex].

    Science.gov (United States)

    Povolotskaia, N P; Efimova, N V; Zherlitsina, L I; Kirilenko, A A; Kortunova, Z V; Golitsin, G S; Senik, I A; Rubinshteĭn, K G

    2010-01-01

    A system of medical weather forecast for the Caucasian Mineral Waters spa-and-resort complex has been modified and updated based on the results of long-term observations of weather conditions in the region of interest with special reference to the bioclimatic regime, atmospheric circulation, aerosol pollution of the near-ground air, ultraviolet radiation, heliomagnetic activity, and meteopathic effects. This system provides a basis for the timely emergency meteopreventive treatment of meteodependent patients and therefore can be instrumental in enhancing efficiency of spa-and-resort rehabilitative therapy.

  12. SpaCEM3: a software for biological module detection when data is incomplete, high dimensional and dependent.

    Science.gov (United States)

    Vignes, Matthieu; Blanchet, Juliette; Leroux, Damien; Forbes, Florence

    2011-03-15

    Among classical methods for module detection, SpaCEM(3) provides ad hoc algorithms that were shown to be particularly well adapted to specific features of biological data: high-dimensionality, interactions between components (genes) and integrated treatment of missingness in observations. The software, currently in its version 2.0, is developed in C++ and can be used either via command line or with the GUI under Linux and Windows environments. The SpaCEM(3) software, a documentation and datasets are available from http://spacem3.gforge.inria.fr/.

  13. Comparison of automated repetitive-sequence-based polymerase chain reaction and spa typing versus pulsed-field gel electrophoresis for molecular typing of methicillin-resistant Staphylococcus aureus.

    Science.gov (United States)

    Church, Deirdre L; Chow, Barbara L; Lloyd, Tracie; Gregson, Daniel B

    2011-01-01

    Automated repetitive polymerase chain reaction (PCR) (DiversiLab, bioMérieux, St. Laurent, Quebec, Canada) and single locus sequence typing of the Staphylococcus protein A (spa) gene with spa-type assignment by StaphType RIDOM software were compared to pulsed-field gel electrophoresis (PFGE) as the "gold standard" method for methicillin-resistant Staphylococcus aureus (MRSA) typing. Fifty-four MRSA isolates were typed by all methods: 10 of known PFGE CMRSA type and 44 clinical isolates. Correct assignment of CMRSA type or cluster occurred for 47 of 54 (87%) of the isolates when using a rep-PCR similarity index (SI) of ≥95%. Rep-PCR gave 7 discordant results [CMRSA1 (3), CMRSA2 (1), CMRSA4 (1), and CMRSA10 (2)], and some CMRSA clusters were not distinguished (CMRSA10/5/9, CMRSA 7/8, and CMRSA3/6). Several spa types occurred within a single PFGE or repetitive PCR types among the 19 different spa types found. spa type t037 was shared by CMRSA3 and CMRSA6 strains, and CMRSA9 and most CMRSA10 strains shared spa type t008. Time to results for PFGE, repetitive PCR, and spa typing was 3-4 days, 24 h, and 48 h, respectively. The annual costs of using spa or repetitive PCR were 2.4× and 1.9× higher, respectively, than PFGE but routine use of spa typing would lower annual labor costs by 0.10 full-time equivalents compared to PFGE. Repetitive PCR is a good method for rapid outbreak screening, but MRSA isolates that share the same repetitive PCR or PFGE patterns can be distinguished by spa typing. Copyright © 2011 Elsevier Inc. All rights reserved.

  14. San Mateo Creek Basin

    Science.gov (United States)

    The San Mateo Creek Basin comprises approximately 321 square miles within the Rio San Jose drainage basin in McKinley and Cibola counties, New Mexico. This basin is located within the Grants Mining District (GMD).

  15. 75 FR 65263 - Virginia Graeme Baker Pool and Spa Safety Act; Public Accommodation; Withdrawal of Proposed Rule

    Science.gov (United States)

    2010-10-22

    ...'' or ``Act'') as ``an inn, hotel, motel, or other place of lodging, except for an establishment located... interpretive rule to interpret ``public accommodations facility'' in the VGB Act as ``an inn, hotel, motel, or... CONSUMER PRODUCT SAFETY COMMISSION 16 CFR Part 1450 Virginia Graeme Baker Pool and Spa Safety Act...

  16. SP-A-enriched surfactant for treatment of rat lung transplants with SP-A deficiency after storage and reperfusion

    NARCIS (Netherlands)

    Erasmus, ME; Hofstede, GJH; Petersen, AH; Batenburg, JJ; Haagsman, HP; Oetomo, SB; Prop, J

    2002-01-01

    Background. The function of pulmonary surfactant is affected by lung transplantation, contributing to impaired lung transplant function. A decreased amount of surfactant protein-A (SP-A) after reperfusion is believed to contribute to the impaired surfactant function. Surfactant treatment has been

  17. LHC suppliers win Golden Hadron awards : Gianfranco Malvestiti and Ernesto Malvestiti de Ernesto Malvestiti SpA (Italie)

    CERN Multimedia

    Maximilien Brice

    2004-01-01

    Ernesto Malvestiti SpA (Italy) is the main manufacturer of the metal collars needed to ensure the rigidity of the superconducting dipoles. The firm was awarded its prize in recognition of the central role it played during the transition from aluminium to stainless-steel collars.

  18. The Environmental Impact of Tourist Activities Performed in the Spa Resorts of Vâlcea Subcarpathians

    Directory of Open Access Journals (Sweden)

    ANA-MARIA ROANGHES-MUREANU

    2012-01-01

    Full Text Available The local environment has a positive influence for tourist trips, both through the conditions it offers, and through its high attractivity. This is the main reason why tourism should play an importan t part in the conservation of the environment and the mantainance of its high standards (both in the area of tourist resorts, and in their sorroundings . The main interests in the field of tourist activi ties should be well aware of the fact that the natural r esorces which are used in this domain are limited. Destructive actions derived from tourist activities are manifested mainly through the inadequate usage of the environment’s resources, in recreation and leisure purposes, and they are increased by the human intervention upon spa re sources, which is often quite brutal. Therefore, the development of tourism should be mad e along with the idea of a sustainable development of the region, which is based on natura l resources and their protection.

  19. SFA-SPA: a suffix array based short peptide assembler for metagenomic data.

    Science.gov (United States)

    Yang, Youngik; Zhong, Cuncong; Yooseph, Shibu

    2015-06-01

    The determination of protein sequences from a metagenomic dataset enables the study of metabolism and functional roles of the organisms that are present in the sampled microbial community. We had previously introduced algorithm and software for the accurate reconstruction of protein sequences from short peptides identified on nucleotide reads in a metagenomic dataset. Here, we present significant computational improvements to the short peptide assembly algorithm that make it practical to reconstruct proteins from large metagenomic datasets containing several hundred million reads, while maintaining accuracy. The improved computational efficiency is achieved using a suffix array data structure that allows for fast querying during the assembly process, and a significant redesign of assembly steps that enables multi-threaded execution. The program is available under the GPLv3 license from sourceforge.net/projects/spa-assembler. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  20. Tourist phenomenon in Geoagiu Spa region within the Central Metaliferi Mountains

    Directory of Open Access Journals (Sweden)

    Dombay Ştefan

    2010-01-01

    Full Text Available The Central Metaliferi Mountains, situated in south-central side of the Apuseni Mountains, have a variety of natural and anthropic touristic potential, but, unfortunately, less known and not enough exploited. After conducting a survey in Geoagiu Spa we specifically recommend the following: increased number of one day tours, which are the main tourist destination in the region, many tours for visiting the major centers of cultural - historical monuments related to our past history, granting economic incentives for organizer of youth groups to attract the youth, diversification of tourist routes with thematic actions: curiosities of nature, environment, organizing sports events with different timetable covering all seasons and all series, attracting local and foreign investors by providing tax incentives and financial programs introducing touristic resort in the international circuit. .

  1. Natural, recreational and cultural-historic values of the Sandanski spa (Pirin mountains

    Directory of Open Access Journals (Sweden)

    Jordanova Marina

    2004-01-01

    Full Text Available One balneological resource of extraordinary value, to which the town of Sandanski owes its existence, are the mineral waters. Within the whole region their total discharge is estimated at 65 1/s while for the town of Sandanski only it is about 25 1/s. Their temperature varies from 33°C to 88°C and the mineral content in them is poor - 0.78-1.02 g/1. That is why diseases can be treated both by drinking the water and by bathing. Besides its diverse natural scenery the Sandanski spa is famous for its important historical events. Melnik is a real monument of the Bulgarian culture. It is designated as a cultural and historical reserve and a museum town and has got the status of a unique settlement of international importance for economic tourism.

  2. Durability of mortars modified by the effect of combining SPA polymers and supplementary cementitious materials

    Directory of Open Access Journals (Sweden)

    Belbachir B.

    2018-01-01

    Full Text Available Nowadays, the major concern of professionals in the field of building materials is to improve the properties induced by the addition of different additives (polymers and mineral additions (Supplementary Cement Materials SCMs and to eventually adapt them to a particular application. This race towards performance has resulted in mortar formulations that are increasingly complex and rich in diversified additions. This is an industry-friendly practice since it generally yields a mortar modified by the combination of a polymer and SCMs, at low cost and low environmental impact, with an improved sustainability in the long term. In order to improve the durability of SCM-modified repair mortars, it seemed interesting to evaluate the influence of adding the styrene polyacrylic (SPA Latex on the properties of these mortars when exposed to aggressive media such as acids. Composite mortars based on pozzolanic mineral additions, containing different levels of 0.5%, 1% and 2%w latex, were stored in acid solutions, for various periods of immersion. The analysis of the microstructure of these mortars, after exposure to acid attack, was carried out by FTIR spectroscopy. The results obtained allowed to demonstrate the beneficial effect of adding the SPA polymer and the pozzolanic additions to the modified materials and to show their improved resistance to acid attacks, such as HNO3 and H3PO4 solutions at 8%. The best durability properties of the mortars modified by the combination of the polymer and the additional cementitious materials observed in this study indicate a longer service life of the repaired structure when using this type of Latex-modified repair materials.

  3. Description of the behavior of an aquifer by using continuous radon monitoring in a thermal spa.

    Science.gov (United States)

    Sainz, Carlos; Rábago, Daniel; Fuente, Ismael; Celaya, Santiago; Quindós, Luis Santiago

    2016-02-01

    Radon ((222)Rn) levels in air and water have been analyzed continuously for almost a year in Las Caldas de Besaya thermal spa, north Spain. Radon is a naturally occurring noble gas from the decay of radium ((226)Ra) both constituents of radioactive uranium 238 series. It has been recognized as a lung carcinogen by the World Health Organization (WHO) and International Agency for Research on Cancer (IARC). Furthermore the Royal Decree R.D 1439/2010 of November, 2010 establishes the obligation to study occupational activities where workers and, where appropriate, members of the public are exposed to inhalation of radon in workplaces such as spas. Together with radon measures several physico-chemical parameters were obtained such as pH, redox potential, electrical conductivity and air and water temperature. The devices used for the study of the temporal evolution of radon concentration have been the RTM 2100, the Radon Scout and gamma spectrometry was complementarily used to determine the transfer factor of the silicone tubes in the experimental device. Radon concentrations obtained in water and air of the spa are high, with an average of 660 Bq/l and 2900 Bq/m(3) respectively, where water is the main source of radon in the air. Radiation dose for workers and public was estimated from these levels of radon. The data showed that the thermal processes can control the behavior of radon which can be also influenced by various physical and chemical parameters such as pH and redox potential. Copyright © 2015 Elsevier B.V. All rights reserved.

  4. Spa therapy together with supervised self-mobilisation improves pain, function and quality of life in patients with chronic shoulder pain: a single-blind randomised controlled trial

    Science.gov (United States)

    Chary-Valckenaere, Isabelle; Loeuille, Damien; Jay, Nicolas; Kohler, François; Tamisier, Jean-Noë; Roques, Christian-François; Boulange, Michel; Gay, Gérard

    2018-02-01

    To determine whether spa therapy has a beneficial effect on pain and disability in patients with chronic shoulder pain, this single-blind randomised controlled clinical trial included patients with chronic shoulder pain due to miscellaneous conditions attending one of four spa centres as outpatients. Patients were randomised into two groups: spa therapy (18 days of standardised treatment combining thermal therapy together with supervised mobilisation in a thermal pool) and controls (spa therapy delayed for 6 months: `immediate versus delayed treatment' paradigm). All patients continued usual treatments during the 6-month follow-up period. The main endpoint was the mean change in the French-Quick DASH (F-QD) score at 6 months. The effect size of spa therapy was calculated, and the proportion of patients reaching minimal clinically important improvement (MCII) was compared. Secondary endpoints were the mean change in SF-36, treatment use and tolerance. One hundred eighty-six patients were included (94 patients as controls, 92 in the spa group) and analysed by intention to treat. At 6 months, the mean change in the F-QD score was statistically significantly greater among spa therapy patients than controls (- 32.6 versus - 8.15%; p pain, function and quality of life in patients with chronic shoulder pain after 6 months compared with usual care.

  5. Enhanced discrimination of highly clonal ST22-methicillin-resistant Staphylococcus aureus IV isolates achieved by combining spa, dru, and pulsed-field gel electrophoresis typing data.

    LENUS (Irish Health Repository)

    Shore, Anna C

    2010-05-01

    ST22-methicillin-resistant Staphylococcus aureus type IV (ST22-MRSA-IV) is endemic in Irish hospitals and is designated antibiogram-resistogram type-pulsed-field group (AR-PFG) 06-01. Isolates of this highly clonal strain exhibit limited numbers of pulsed-field gel electrophoresis (PFGE) patterns and spa types. This study investigated whether combining PFGE and spa typing with DNA sequencing of the staphylococcal cassette chromosome mec element (SCCmec)-associated direct repeat unit (dru typing) would improve isolate discrimination. A total of 173 MRSA isolates recovered in one Irish hospital during periods in 2007 and 2008 were investigated using antibiogram-resistogram (AR), PFGE, spa, dru, and SCCmec typing. Isolates representative of each of the 17 pulsed-field group 01 (PFG-01) spa types identified underwent multilocus sequence typing, and all isolates were ST22. Ninety-seven percent of isolates (168 of 173) exhibited AR-PFG 06-01 or closely related AR patterns, and 163 of these isolates harbored SCCmec type IVh. The combination of PFGE, spa, and dru typing methods significantly improved discrimination of the 168 PFG-01 isolates, yielding 65 type combinations with a Simpson\\'s index of diversity (SID) of 96.53, compared to (i) pairwise combinations of spa and dru typing, spa and PFGE typing, and dru and PFGE typing, which yielded 37, 44, and 43 type combinations with SIDs of 90.84, 91.00, and 93.57, respectively, or (ii) individual spa, dru, and PFGE typing methods, which yielded 17, 17, and 21 types with SIDs of 66.9, 77.83, and 81.34, respectively. Analysis of epidemiological information for a subset of PFG-01 isolates validated the relationships inferred using combined PFGE, spa, and dru typing data. This approach significantly enhances discrimination of ST22-MRSA-IV isolates and could be applied to epidemiological investigations of other highly clonal MRSA strains.

  6. Real-life effectiveness of spa therapy in rheumatic and musculoskeletal diseases: a retrospective study of 819 patients

    Science.gov (United States)

    Karagülle, Mine; Kardeş, Sinan; Karagülle, Müfit Zeki

    2017-11-01

    The objective of this study is to determine the use and efficacy of spa therapy in patients with a wide spectrum of rheumatic and musculoskeletal diseases under real-life clinical practice circumstances. In this retrospective observational study at the Medical Ecology and Hydroclimatology Department of Istanbul Faculty of Medicine, the records of all adult patients with rheumatic and musculoskeletal diseases who were prescribed a spa therapy in various health resorts in Turkey between 2002 and 2012 were analyzed. Patients sojourned to and stayed at a health resort and followed a usual 2-week course of spa therapy. The patients were examined within a week before and after the spa therapy at the department by the physicians and outcome measures were pain intensity (visual analog scale, VAS), patient's general evaluation (VAS), physician's general evaluation (VAS), Health Assessment Questionnaire (HAQ), Lequesne's Functional Index (LFI), Western Ontario and McMaster Universities Index (WOMAC), Waddell Index (WI), Neck Pain and Disability Scale (NPDS), Shoulder Disability Questionnaire (SDQ), Fibromyalgia Impact Questionnaire (FIQ), and Beck's Depression Inventory (BDI). In total, 819 patients were included in the analysis. The diagnoses were 536 osteoarthritis; 115 fibromyalgia; 50 lumbar disc herniation; 34 cervical disc herniation; 23 nonspecific low back pain; 22 ankylosing spondylitis; 16 rheumatoid arthritis; 9 rotator cuff tendinitis; and 14 other conditions/diseases including scoliosis, stenosing flexor tenosynovitis, congenital hip dislocation in adult, Behçet's disease, de Quervain tendinopathy, psoriatic arthritis, osteoporosis, fracture rehabilitation, and diffuse idiopathic skeletal hyperostosis. Statistically significant decrease in pain scores was found in all patients except hip osteoarthritis ( p = 0.063) and rheumatoid arthritis ( p = 0.134) subgroups; and statistically significant improvement in function in all patients except hip osteoarthritis ( p

  7. Brote de legionelosis asociado a un balneario Legionella outbreak at a spa

    Directory of Open Access Journals (Sweden)

    E. Serrano Ibarbia

    2001-06-01

    Full Text Available En 1998 el inicio de la temporada de actividad de un balneario en Gipuzkoa coincidió con la detección de un brote de legionelosis asociado al mismo, lo cual condujo al cierre de la instalación y al estudio epidemiológico -casos y controles- y ambiental oportunos. Se definió como caso toda persona que durante su estancia en el balneario o durante los 10 días siguientes presentará neumonía o un cuadro febril compatible con fiebre de Pontiac.El estudio ambiental incluyó la inspección del balneario y entorno y muestreos de los sistemas sanitarios de agua y de los elementos de hidroterapia.De las 287 personas encuestadas de la Comunidad Autónoma Vasca, el 12.5% cumplían con la definición de caso; 9 casos presentaron neumonía y 26 fiebre de Pontiac. La curva epidémica se inició el 7 de mayo, alcanzando un pico los días 14 y 15 de mayo y finalizando el día 20. El riesgo de enfermar ajustado por edad, sexo y consumo de tabaco se asoció con la duración de la estancia en el balneario (OR=118.5, 95% I.C: 18.7-750.2 y con el uso de una piscina (OR=10.5, 95% I.C: 1.3-82.6. Se detecto L. pneumophila serogrupo1 en recuentos superiores a 103 ufc/l en diversos puntos de la red de hidroterapia y en la ducha de la habitación de uno de los enfermos. El análisis por electroforesis en campos pulsados de una muestra biológica y muestras ambientales permitió la confirmación genotípica. El establecimiento se abrió al público tras realizar un tratamiento de choque y comprobar que transcurridos 15 días no se detectó L. pneumophila en las muestras ambientales.The start of seasonal activity at a spa in Guipuzcoa coincided with the detection of an associated legionnaire outbreak in 1998. This led to the closure of the premises and to the carrying out of opportune environmental and epidemiological studies. The latter included case-control study. A case was defined as a person who, either during his stay or in a period of 10 days thereafter

  8. Genomic and Functional Characterization of the Unusual pLOCK 0919 Plasmid Harboring the spaCBA Pili Cluster in Lactobacillus casei LOCK 0919

    Czech Academy of Sciences Publication Activity Database

    Aleksandrzak-Piekarczyk, T.; Koryszewska-Baginska, A.; Grynberg, M.; Nowak, A.; Cukrowska, B.; Kozáková, Hana; Bardowski, J.

    2016-01-01

    Roč. 8, č. 1 (2016), s. 202-217 ISSN 1759-6653 Institutional support: RVO:61388971 Keywords : adhesion * spaCBA pilus cluster * lactobacillus Subject RIV: EC - Immunology Impact factor: 3.979, year: 2016

  9. Tectonic and Hydrothermal Activities in Debagh, Guelma Basin (Algeria

    Directory of Open Access Journals (Sweden)

    Said Maouche

    2013-01-01

    Full Text Available Quaternary and Pliocene travertines, deposited from hot springs, can reveal much about neotectonic and hydrothermal activity. The aim of this work is the understanding of the actual tectonic activity in the Guelma Basin and in one of its spa structures. Gravity data were collected during a field study in the Hammam Debagh (HD area and then analyzed to better highlight the architecture of its subsurface underlying structures. This analysis was performed by means of a Bouguer anomaly, upward continuations, and residual and derivative maps. Comparison of gravity maps, field geology, geomorphic observations, and structural maps allowed us to identify the major structural features in the Hammam Debagh. As a result, we confirm the position of the Hammam Debagh active fault which is superimposed to the hydrothermal active source in the NW-SE direction characterized by a negative gravity anomaly.

  10. [The prospects for the further development of the Belokurikha spa and health resort territory in the Altai Krai (region)].

    Science.gov (United States)

    Dzhabarova, N K; Yakovenko, E S; Sidorina, N G; Kokhanenko, A A; Vorob'ev, V A; Zaitsev, A A; Kovalenko, T S; Zhilyakov, I V

    2016-01-01

    We undertook a balneological survey of the Belokurikha spa and health resort territory with the purpose of distinguishing and identifying the potential health-improvement areas most promising for the extension and optimization of the therapeutic, tourist and recreational activities. The assessment was focused on the characteristic of the landscape and climatic conditions of the territory, the possibilities for the development of the existing resources of mineral waters and therapeutic muds as well as for the discovery of the potential new ones. The recommendations are proposed to promote the development of different forms of tourism with special reference to its medical and health-improvement aspects. It is suggested that the territory of the «Belokurikha» resort», «Belokurikha-2» and «Belokurikha-3» health-improvement areas should be integrated into a single spa-and-health resort district of federal importance.

  11. SMART-1 highlights and relevant studies on early bombardment and geological processes on rocky planets

    International Nuclear Information System (INIS)

    Foing, B H; Koschny, D; Frew, D; Almeida, M; Zender, J; Heather, D; Peters, S; Racca, G D; Marini, A; Stagnaro, L; Josset, J L; Beauvivre, S; Grande, M; Kellett, B; Huovelin, J; Nathues, A; Mall, U; Ehrenfreund, P; McCannon, P

    2008-01-01

    We present results from SMART-1 science and technology payload, in the context of the Nobel symposium on 'Physics of Planetary Systems'. SMART-1 is Europe' first lunar mission (Foing et al 2000 LPSC XXXI Abstract 1677 (CDROM); Foing et al 2001 Earth, Moon Planets 85-86 523-31; Marini et al 2002 Adv. Space Res. 30 1895-900; Racca et al 2001 Earth Moon Planets 85-86 379-95, Racca et al 2002 Planet Space Sci. 50 1323-37) demonstrating technologies for future science and exploration missions, and providing advances in our understanding of lunar origin and evolution, and general planetary questions. The mission also contributes a step in developing an international program of lunar exploration. The spacecraft, launched on 27 September 2003 as an Ariane 5 Auxiliary passenger to geostationary transfer orbit (GTO), performed a 14-month long cruise using a tiny thrust of electric propulsion alone, reached lunar capture in November 2004, and lunar science orbit in March 2005. SMART-1 carried 7 hardware experiments (Foing et al 2003 Adv. Space Res. 31 2323, Foing et al 2005 LPI/LPSC XXXVI 2404 (CDROM)) performing 10 investigations, including 3 remote-sensing instruments, used during the cruise, the mission' nominal six-months and one-year extension in lunar science orbit. Three remote sensing instruments, D-CIXS, SIR and AMIE, have returned data that are relevant to a broad range of lunar studies. The mission provided regional and global x-ray measurements of the Moon, global high-spectral resolution NIR spectrometry, high spatial resolution colour imaging of selected regions. The South Pole-Aitken Basin (SPA) and other impact basins have been prime targets for studies using the SMART-1 suite of instruments. Combined, these should aid a large number of science studies, from bulk crustal composition and theories of lunar origin/evolution, the global and local crustal composition, to the search for cold traps at the lunar poles and the mapping of potential lunar resources. We

  12. Structural and Biochemical Characterization of Spa47 Provides Mechanistic Insight into Type III Secretion System ATPase Activation and Shigella Virulence Regulation.

    Science.gov (United States)

    Burgess, Jamie L; Burgess, R Alan; Morales, Yalemi; Bouvang, Jenna M; Johnson, Sean J; Dickenson, Nicholas E

    2016-12-09

    Like many Gram-negative pathogens, Shigella rely on a complex type III secretion system (T3SS) to inject effector proteins into host cells, take over host functions, and ultimately establish infection. Despite these critical roles, the energetics and regulatory mechanisms controlling the T3SS and pathogen virulence remain largely unclear. In this study, we present a series of high resolution crystal structures of Spa47 and use the structures to model an activated Spa47 oligomer, finding that ATP hydrolysis may be supported by specific side chain contributions from adjacent protomers within the complex. Follow-up mutagenesis experiments targeting the predicted active site residues validate the oligomeric model and determined that each of the tested residues are essential for Spa47 ATPase activity, although they are not directly responsible for stable oligomer formation. Although N-terminal domain truncation was necessary for crystal formation, it resulted in strictly monomeric Spa47 that is unable to hydrolyze ATP, despite maintaining the canonical ATPase core structure and active site residues. Coupled with studies of ATPase inactive full-length Spa47 point mutants, we find that Spa47 oligomerization and ATP hydrolysis are needed for complete T3SS apparatus formation, a proper translocator secretion profile, and Shigella virulence. This work represents the first structure-function characterization of Spa47, uniquely complementing the multitude of included Shigella T3SS phenotype assays and providing a more complete understanding of T3SS ATPase-mediated pathogen virulence. Additionally, these findings provide a strong platform for follow-up studies evaluating regulation of Spa47 oligomerization in vivo as a much needed means of treating and perhaps preventing shigellosis. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

  13. Structural and Biochemical Characterization of Spa47 Provides Mechanistic Insight into Type III Secretion System ATPase Activation and Shigella Virulence Regulation*

    Science.gov (United States)

    Burgess, Jamie L.; Burgess, R. Alan; Morales, Yalemi; Bouvang, Jenna M.; Johnson, Sean J.; Dickenson, Nicholas E.

    2016-01-01

    Like many Gram-negative pathogens, Shigella rely on a complex type III secretion system (T3SS) to inject effector proteins into host cells, take over host functions, and ultimately establish infection. Despite these critical roles, the energetics and regulatory mechanisms controlling the T3SS and pathogen virulence remain largely unclear. In this study, we present a series of high resolution crystal structures of Spa47 and use the structures to model an activated Spa47 oligomer, finding that ATP hydrolysis may be supported by specific side chain contributions from adjacent protomers within the complex. Follow-up mutagenesis experiments targeting the predicted active site residues validate the oligomeric model and determined that each of the tested residues are essential for Spa47 ATPase activity, although they are not directly responsible for stable oligomer formation. Although N-terminal domain truncation was necessary for crystal formation, it resulted in strictly monomeric Spa47 that is unable to hydrolyze ATP, despite maintaining the canonical ATPase core structure and active site residues. Coupled with studies of ATPase inactive full-length Spa47 point mutants, we find that Spa47 oligomerization and ATP hydrolysis are needed for complete T3SS apparatus formation, a proper translocator secretion profile, and Shigella virulence. This work represents the first structure-function characterization of Spa47, uniquely complementing the multitude of included Shigella T3SS phenotype assays and providing a more complete understanding of T3SS ATPase-mediated pathogen virulence. Additionally, these findings provide a strong platform for follow-up studies evaluating regulation of Spa47 oligomerization in vivo as a much needed means of treating and perhaps preventing shigellosis. PMID:27770024

  14. The rSPA Processes of River Water-quality Analysis System for Critical Contaminate Detection, Classification Multiple-water-quality-parameter Values and Real-time Notification

    OpenAIRE

    Chalisa VEESOMMAI; Yasushi KIYOKI

    2016-01-01

    The water quality analysis is one of the most important aspects of designing environmental systems. It is necessary to realize detection and classification processes and systems for water quality analysis. The important direction is to lead to uncomplicated understanding for public utilization. This paper presents the river Sensing Processing Actuation processes (rSPA) for determination and classification of multiple-water- parameters in Chaophraya river. According to rSPA processes of multip...

  15. [The impact of the spa therapy on reduction of the perception of pain intensity in patients with degenerative joints and disc disease].

    Science.gov (United States)

    Kuciel-Lewandowska, Jadwiga; Paprocka-Borowicz, Małgorzata

    2015-01-01

    Degenerative joints and disc disease is accompanied by chronic pain which is the main symptom of the disease. Medical spa therapy has the task of providing comprehensive treatment embracing diseases of limbs as well as other systems and the essential role of medical treatment, in particular spa therapy, is pain relief. The aim of the study was to evaluate the effect of the spa treatment on the level of pain perception in patients with degenerative joints and disc disease. The observation embraced 120 people with degenerative joints and disc disease treated in the spa. The study included a comprehensive therapy conducted over a 21-day stays at the spa Przerzeczyn-Zdrój with the application of selected physical treatments, physiotherapy and the use of therapeutic natural resources: peloid mud and healing radon-sulphide water. Moreover, there was psychological counseling and health education conducted. The study also included observation of 21 persons from the control group. However, the patients in the control group did not benefit from balneotherapy, psychological care and education. There was a standard VAS scale for pain and non-standard questionnaire of pain assessment constructed for the study purposes. The assessment of pain using the VAS scale and questionnaire of pain assessment both in the study group and the control group were performed before and after the treatment. The results were analyzed statistically, there was Statistica program in Polish version used. In the analysis of the obtained results there were two tests scheduled: the sign test, the Wilcoxon test and descriptive statistics. As a result of the spa therapy and treatments administered on an outpatient basis there was reduction of pain intensity observed. 1. Spa therapy and outpatient treatment reduce the level of pain in patients with degenerative joints and disc disease. 2. The reduction of pain level was more effective in case of therapy conducted in the spa.

  16. Diagnosis of the socionic temperament of personality and creating a psychological portrait of the Western European SPA and wellness tourists in Bulgaria

    Science.gov (United States)

    Stoyanova, Milena

    2017-03-01

    Human personality is a set of psychological characteristics that distinguishes it from others. However people can be classified as congenital personality types, interactions that are precisely defined. The aim of this article is to characterize the socionic temperament and psychological profile of the spa and wellness tourists in Bulgaria. The study is based on a survey of 460 tourists who visited Bulgarian spa centers in the summer and autumn of 2015.

  17. Diagnosis of the socionic temperament of personality and creating a psychological portrait of the Western European SPA and wellness tourists in Bulgaria

    Directory of Open Access Journals (Sweden)

    Stoyanova Milena

    2017-03-01

    Full Text Available Human personality is a set of psychological characteristics that distinguishes it from others. However people can be classified as congenital personality types, interactions that are precisely defined. The aim of this article is to characterize the socionic temperament and psychological profile of the spa and wellness tourists in Bulgaria. The study is based on a survey of 460 tourists who visited Bulgarian spa centers in the summer and autumn of 2015.

  18. State-wide surveillance of antibiotic resistance patterns and spa types of methicillin-resistant Staphylococcus aureus from blood cultures in North Rhine-Westphalia, 2011-2013.

    Science.gov (United States)

    Cuny, C; Layer, F; Werner, G; Harmsen, D; Daniels-Haardt, I; Jurke, A; Mellmann, A; Witte, W; Köck, R

    2015-08-01

    Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of bacteraemia. We aimed to obtain a complete picture of severe MRSA infections by characterizing all MRSA isolates from bloodstream infections in the largest German federal state (North Rhine-Westphalia, 18 million inhabitants) using S. aureus protein A (spa) sequence-typing and antimicrobial susceptibility testing. MRSA isolates (n = 1952) were collected prospectively (2011-2013) and spa-typed. Among 181 different spa types, t003 (n = 746 isolates; 38.2%) and t032 (n = 594; 30.4%) were predominant. Analysis of the geographical occurrence of spa clonal complexes (spa-CCs) and spa types revealed divergent distribution between federal state districts for spa-CCs 003 (p resistant to fluoroquinolones, 78% to erythromycin, 70% to clindamycin, 4% to gentamicin, 2% to rifampicin, 0.4% to daptomycin, 0.1% to linezolid and 0% to vancomycin, respectively. Vancomycin MICs of 2 mg/L involved 0.5% of the isolates. In conclusion, the detection of regional molecular clusters added valuable information for epidemiological case tracing and allowed conclusions to be reached on the importance of newly emerging MRSA reservoirs, such as livestock (spa-CC011), for MRSA bacteraemia in some parts of the federal state. Susceptibility testing revealed broad resistance to substances used for oral treatment, but demonstrated that those antibiotics that are mostly applied for treatment of MRSA bacteraemia and important combination partners were highly susceptible. Copyright © 2015 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

  19. Distribution of the Most Prevalent Spa Types among Clinical Isolates of Methicillin-Resistant and -Susceptible Staphylococcus aureus around the World: A Review

    Science.gov (United States)

    Asadollahi, Parisa; Farahani, Narges Nodeh; Mirzaii, Mehdi; Khoramrooz, Seyed Sajjad; van Belkum, Alex; Asadollahi, Khairollah; Dadashi, Masoud; Darban-Sarokhalil, Davood

    2018-01-01

    Background: Staphylococcus aureus, a leading cause of community-acquired and nosocomial infections, remains a major health problem worldwide. Molecular typing methods, such as spa typing, are vital for the control and, when typing can be made more timely, prevention of S. aureus spread around healthcare settings. The current study aims to review the literature to report the most common clinical spa types around the world, which is important for epidemiological surveys and nosocomial infection control policies. Methods: A search via PubMed, Google Scholar, Web of Science, Embase, the Cochrane library, and Scopus was conducted for original articles reporting the most prevalent spa types among S. aureus isolates. The search terms were “Staphylococcus aureus, spa typing.” Results: The most prevalent spa types were t032, t008 and t002 in Europe; t037 and t002 in Asia; t008, t002, and t242 in America; t037, t084, and t064 in Africa; and t020 in Australia. In Europe, all the isolates related to spa type t032 were MRSA. In addition, spa type t037 in Africa and t037and t437 in Australia also consisted exclusively of MRSA isolates. Given the fact that more than 95% of the papers we studied originated in the past decade there was no option to study the dynamics of regional clone emergence. Conclusion: This review documents the presence of the most prevalent spa types in countries, continents and worldwide and shows big local differences in clonal distribution. PMID:29487578

  20. Distribution of the Most Prevalent Spa Types among Clinical Isolates of Methicillin-Resistant and -Susceptible Staphylococcus aureus around the World: A Review

    Directory of Open Access Journals (Sweden)

    Parisa Asadollahi

    2018-02-01

    Full Text Available Background:Staphylococcus aureus, a leading cause of community-acquired and nosocomial infections, remains a major health problem worldwide. Molecular typing methods, such as spa typing, are vital for the control and, when typing can be made more timely, prevention of S. aureus spread around healthcare settings. The current study aims to review the literature to report the most common clinical spa types around the world, which is important for epidemiological surveys and nosocomial infection control policies.Methods: A search via PubMed, Google Scholar, Web of Science, Embase, the Cochrane library, and Scopus was conducted for original articles reporting the most prevalent spa types among S. aureus isolates. The search terms were “Staphylococcus aureus, spa typing.”Results: The most prevalent spa types were t032, t008 and t002 in Europe; t037 and t002 in Asia; t008, t002, and t242 in America; t037, t084, and t064 in Africa; and t020 in Australia. In Europe, all the isolates related to spa type t032 were MRSA. In addition, spa type t037 in Africa and t037and t437 in Australia also consisted exclusively of MRSA isolates. Given the fact that more than 95% of the papers we studied originated in the past decade there was no option to study the dynamics of regional clone emergence.Conclusion: This review documents the presence of the most prevalent spa types in countries, continents and worldwide and shows big local differences in clonal distribution.

  1. Distribution of Virulence Genes in spa Types of Methicillin-resistant Staphylococcus aureus Isolated from Patients in Intensive Care Units

    OpenAIRE

    Kim, Taeksoo; Yi, Jongyoun; Hong, Ki Ho; Park, Jeong-Su; Kim, Eui-Chong

    2011-01-01

    Background Various virulence factors and superantigens are encoded by mobile genetic elements. The relationship between clonal background and virulence factors differs in different geographic regions. We compared the distribution and relationship of spa types and virulence genes among methicillin-resistant Staphylococcus aureus (MRSA) strains isolated from a tertiary hospital in 2000-01 and 2007-08. Methods In 2000-01 and 2007-08, 94 MRSA strains were collected from 3 intensive care units at ...

  2. Investigation of a long time series of CO2 from a tall tower using WRF-SPA

    Science.gov (United States)

    Smallman, Luke; Williams, Mathew; Moncrieff, John B.

    2013-04-01

    Atmospheric observations from tall towers are an important source of information about CO2 exchange at the regional scale. Here, we have used a forward running model, WRF-SPA, to generate a time series of CO2 at a tall tower for comparison with observations from Scotland over multiple years (2006-2008). We use this comparison to infer strength and distribution of sources and sinks of carbon and ecosystem process information at the seasonal scale. The specific aim of this research is to combine a high resolution (6 km) forward running meteorological model (WRF) with a modified version of a mechanistic ecosystem model (SPA). SPA provides surface fluxes calculated from coupled energy, hydrological and carbon cycles. This closely coupled representation of the biosphere provides realistic surface exchanges to drive mixing within the planetary boundary layer. The combined model is used to investigate the sources and sinks of CO2 and to explore which land surfaces contribute to a time series of hourly observations of atmospheric CO2 at a tall tower, Angus, Scotland. In addition to comparing the modelled CO2 time series to observations, modelled ecosystem specific (i.e. forest, cropland, grassland) CO2 tracers (e.g., assimilation and respiration) have been compared to the modelled land surface assimilation to investigate how representative tall tower observations are of land surface processes. WRF-SPA modelled CO2 time series compares well to observations (R2 = 0.67, rmse = 3.4 ppm, bias = 0.58 ppm). Through comparison of model-observation residuals, we have found evidence that non-cropped components of agricultural land (e.g., hedgerows and forest patches) likely contribute a significant and observable impact on regional carbon balance.

  3. The Present and Future of Szigetvár Spa – An Economic Analysis of Geothermal Energy Investment

    Directory of Open Access Journals (Sweden)

    Judit Pálné Schreiner

    2014-09-01

    Full Text Available In Hungary, geothermal energy has proved to be an economical source of energy for direct use. It highlights the pros and cons of including renewable energy in the power generation mix of Hungary, and the pros and cons of local application. This paper looks at the operation of Szigetvár Spa from both economic and social aspects. In this study, qualitative analysis is used for the basic economic and social introduction of the Spa, and then real options, based on quantitative methods, are described to identify the long-term financial consequences of the project. In 1966, thermal water was found in Szigetvár. In 1997, this thermal water was certified as medicinal water. The wellhead temperature of Szigetvár thermal water is 62°C in the 790 metres deep thermal well. It is used as so-called domestic hot water in the Szent István housing estate and in Szigetvár Spa. One of the problems with the project is that it is based on single stage thermal water utilization, another problem is that the waste water is too hot. This can be solved by exploiting the heat energy of thermal water more intensively. This way, maximum benefits can be gained from geothermal energy with minimum use of energy. Static and dynamic investment analyses were carried out to examine the spa from a financial aspect. The methods used include static payback period, average rate of return, levelized cost of electricity, net present value, profitability index, dynamic payback period, internal rate of return and real options. By pricing geothermal technology, it is possible to identify the strategic value of flexibility, to quantify what was previously left unquantified, and thus to show that geothermal investments are profitable not only from a social but also from a financial aspect as well.

  4. SPECIFICS OF PHYSIOTHERAPY OF PATIENTS TRANSFERRED AFTER ORTHOPEDIC OPERATIONS DIRECTLY ON THE SO-CALLED SPA BUNK

    OpenAIRE

    JOHANUSOVÁ, Lucie

    2015-01-01

    This bachelor thesis addresses the specificity of physiotherapy of patients, transferred to a so-called spa bed, after orthopedic surgery. Among the most performed orthopedic surgeries are the total hip replacement and the total knee replacement. Arthrosis is the most common reason for the implantation of joint replacements. It is a painful and life-aggravating disease which has a tremendous impact on the patient's quality of life. In order to lower the risk of the patient having to take a re...

  5. [Marketing macroenvironment of a sanatorium and spa facility as a study object and a factor of strategic decision making].

    Science.gov (United States)

    Babaskin, D V

    2009-01-01

    Analysis of marketing macroenvironment is an important stage in the formulation of the strategy for the development and operation of a therapeutic and preventive healthcare facility making possible rapid adjustment to sharply changing marketing conditions. The possibility of using expert evaluation for the analysis of the marketing macroenvironment of a sanatorium and spa facility and a concrete medical care service provided (peloidotherapy) is illustrated. The study covers five aspects of marketing macroenvironment, viz. socio-demographic, technological, economic, political and ecological.

  6. Forecasting of the volume of the SPA and wellness tourism receipts in the south-west Bulgaria

    Directory of Open Access Journals (Sweden)

    Preslav Mihaylov Dimitrov

    2017-06-01

    Full Text Available The present paper regards the application of some forecasting methods in regards to the SPA and Wellness tourism in South-West Bulgaria such as: the linear trend forecasting, the double exponential forecasting (the Holt’s method, the ARIMA method, the naïve method and the indexed naïve method. Specially designed model for estimation of the weight coefficient needed for determining the size of the sector of the SPA and Wellness tourism in the time series of the available data and in the forecast values is being presented. Future and past predictions have been achieved based on statistical records of a time series of 18-year periods. The present paper regards also several major problems in the application of the univariate forecasting methods for the purpose of the long-run forecasting of the volume of the tourism receives and especially the ones in the sub-sector of the SPA and Wellness tourism in South-West Bulgaria. These problems include as: (i the problem of finding of a suitable general indicator; (ii Determining the time series pattern, or the so-called “forecast profile” and selecting and using of suitable forecasting techniques; (iii Calculating of short-run and long-run forecasts; (iv comparing of the results of the forecast techniques on the basis of the errors in the forecasts; (v Estimating the size of the SPA and Wellness tourism in South-West Bulgaria in certain terms, so that the forecast(s of the above-mentioned general indicator could be particularized especially for regarded sub-sector and region. The results from the different forecasting methods and techniques are being presented and conclusions are drawn on the reliability of the achieved forecasts.

  7. Analisa Pengaruh Brand Image Terhadap Customer Loyalty Dengan Customer Satisfaction Sebagai Mediator Pada the Dreamland Luxury Villas and Spa, Bali.

    OpenAIRE

    Leliga, Felicia Juliani

    2013-01-01

    Penelitian ini dilakukan untuk mengetahui customer loyalty pada brand The Dreamland Luxury Villas and Spa, Bali melalui penilaian responden terhadap dimensi brand image yang terdiri dari brand strength, brand favorability, dan brand uniqueness, dengan menggunakan customer satisfaction sebagai variabel mediator. Dalam penelitian ini, penulis menggunakan metode kuantitatif dengan teknik partial least square (PLS). Dari hasil analisa, disimpulkan bahwa tidak ada pengaruh brand strength dan brand...

  8. SOME ASPECTS OF SPA TOURIST MARKET SEGMENTATION (A Closer Look at the Case Study on Shipkovo Village Experience, Bulgaria

    Directory of Open Access Journals (Sweden)

    Vanya Kuzdova BANABAKOVA

    2006-06-01

    Full Text Available The present report explores the possibilities for spa tourist market segmentation. Based on analyses of the market and competition, the key criteria of said segmentation is established on the bases of market and competition analysis, as well as the target segments are determined, the latter being actual and potential consumers of the tourist product, offered in the region of Shipkovo village, Troyan Municipality.

  9. Impact of serum SP-A and SP-D levels on comparison and prognosis of idiopathic pulmonary fibrosis

    OpenAIRE

    Wang, Kai; Ju, Qing; Cao, Jing; Tang, Wenze; Zhang, Jian

    2017-01-01

    Abstract Background and objective: Idiopathic pulmonary fibrosis (IPF) has a poor prognosis in general; however, it is heterogeneous to detect relative biomarkers for predicting the disease progression. Serum biomarkers can be conveniently collected to detect and help to differentially diagnose IPF and predict IPF prognosis. This meta-analysis aimed to evaluate the use of serum surfactant proteins A and D (SP-A and SP-D) for differential diagnosis and prognosis of IPF. Methods: Relevant artic...

  10. Expression, purification, crystallization and preliminary crystallographic analysis of SpaA, a major pilin from Corynebacterium diphtheriae

    International Nuclear Information System (INIS)

    Kang, Hae Joo; Paterson, Neil G.; Baker, Edward N.

    2009-01-01

    SpaA, one of the major pilins of C. diphtheriae, has been expressed, purified and crystallized and X-ray diffraction data have been collected to 1.6 Å resolution. Bacterial pili are cell-surface organelles that are critically involved in adhesion to host cells, leading to the colonization of host tissues and the establishment of infections. Whereas the pili of Gram-negative bacteria have been extensively studied, those of Gram-positive bacteria came to light only recently after the discovery and characterization of Corynebacterium diphtheriae pili. These newly discovered pili are formed by the covalent polymerization of pilin subunits catalyzed by sortase enzymes, making them fundamentally different from the noncovalent pilin assemblies of Gram-negative bacteria. Here, the expression, crystallization and preliminary crystallographic analysis of SpaA, which forms the shaft of one of the three types of pili expressed by C. diphtheriae, are reported. SpaA 53–486 crystals diffracted to 1.6 Å resolution and belonged to space group P2 1 2 1 2 1 , with unit-cell parameters a = 34.9, b = 64.1, c = 198.7 Å, α = β = γ = 90°

  11. Valuation of Tourist Potential Spa of Niš (Niška Banja Area (South-east Serbia

    Directory of Open Access Journals (Sweden)

    Jovica Mojić

    2011-07-01

    Full Text Available Tourism potential of the tourist destination is determined using the evaluation of natural and anthropogenic resources which are significant for the development of certain forms of tourism. Specifically, for the evaluation of tourist potential Spa of Niš, a tourist and geographical location and a concrete zone size can be used, as well as the attractiveness of natural and anthropogenic resources, facilities already built of infra and supra structures and so on. According to the recommendation of the World Tourism Organization (UNWTO for precise inventory and assessment of tourist values, it is desirable to outline a standard form by which the researchers could perform an inventory of tourist potential of a particular spatial area, regardless of size or hierarchical rang. In this paper, in a universal way, through analysis and synthesis of the values of internal and external factors, an attempt has been made to determine the value of the tourism potential Spa of Niš. In addition, a scoring method is used, by which it is possible to examine and compare a number of properties of various tourism resources. Lack of the scoring method can be seen through subjectivity which prevails in all stages of evaluation, but if adequately implemented, it still can give satisfactory results. The main aim of the research to rank the valorization of tourism potential, identify the advantages and disadvantages Spa of Niš tourism, as compared to other tourist destination of health and wellness tourism in Serbia, and in the wider environment, as well.

  12. The effects of balance and postural stability exercises on spa based rehabilitation programme in patients with ankylosing spondylitis.

    Science.gov (United States)

    Gunay, Selim M; Keser, Ilke; Bicer, Zemzem T

    2017-09-08

    Ankylosing spondylitis (AS) can cause severe functional disorders that lead to loss of balance. The aim of this study was to investigate the effects of balance and postural stability exercises on spa based rehabilitation programme in AS subjects. Twenty-one participants were randomized to the study (n= 11) and control groups (n= 10). Patients balance and stability were assessed with the Berg Balance Scale (BBS), Timed Up and Go (TUG) Test, Single Leg Stance Test (SLST) and Functional Reach Test (FRT). AS spesicied measures were used for assessing to other parameters. The treatment plan for both groups consisted of conventional transcutaneous electrical nerve stimulation (TENS), spa and land-based exercises 5 days per week for 3 weeks. The study group performed exercises based on postural stability and balance with routine physiotherapy practice in thermal water and in exercise room. The TUG, SLST and FUT scores were significantly increased in the study group. In both groups, the BASMI, BASFI, BASDAI and ASQoL scores decreased significantly by the end of the treatment period (pbalance and stability exercises in addition to spa based routine approaches can increase the duration of maintaining balance and can improve the benefits of physiotherapy.

  13. New insights about pilus formation in gut-adapted Lactobacillus rhamnosus GG from the crystal structure of the SpaA backbone-pilin subunit

    Science.gov (United States)

    Chaurasia, Priyanka; Pratap, Shivendra; von Ossowski, Ingemar; Palva, Airi; Krishnan, Vengadesan

    2016-01-01

    Thus far, all solved structures of pilin-proteins comprising sortase-assembled pili are from pathogenic genera and species. Here, we present the first crystal structure of a pilin subunit (SpaA) from a non-pathogen host (Lactobacillus rhamnosus GG). SpaA consists of two tandem CnaB-type domains, each with an isopeptide bond and E-box motif. Intriguingly, while the isopeptide bond in the N-terminal domain forms between lysine and asparagine, the one in the C-terminal domain atypically involves aspartate. We also solved crystal structures of mutant proteins where residues implicated in forming isopeptide bonds were replaced. Expectedly, the E-box-substituted E139A mutant lacks an isopeptide bond in the N-terminal domain. However, the C-terminal E269A substitution gave two structures; one of both domains with their isopeptide bonds present, and another of only the N-terminal domain, but with an unformed isopeptide bond and significant conformational changes. This latter crystal structure has never been observed for any other Gram-positive pilin. Notably, the C-terminal isopeptide bond still forms in D295N-substituted SpaA, irrespective of E269 being present or absent. Although E-box mutations affect SpaA proteolytic and thermal stability, a cumulative effect perturbing normal pilus polymerization was unobserved. A model showing the polymerized arrangement of SpaA within the SpaCBA pilus is proposed. PMID:27349405

  14. Crystallization and X-ray diffraction analysis of SpaE, a basal pilus protein from the gut-adapted Lactobacillus rhamnosus GG.

    Science.gov (United States)

    Mishra, Arjun K; Megta, Abhin Kumar; Palva, Airi; von Ossowski, Ingemar; Krishnan, Vengadesan

    2017-06-01

    SpaE is the predicted basal pilin subunit in the sortase-dependent SpaFED pilus from the gut-adapted and commensal Lactobacillus rhamnosus GG. Thus far, structural characterization of the cell-wall-anchoring basal pilins has remained difficult and has been limited to only a few examples from pathogenic genera and species. To gain a further structural understanding of the molecular mechanisms that are involved in the anchoring and assembly of sortase-dependent pili in less harmful bacteria, L. rhamnosus GG SpaE for crystallization was produced by recombinant expression in Escherichia coli. Although several attempts to crystallize the SpaE protein were unsuccessful, trigonal crystals that diffracted to a resolution of 3.1 Å were eventually produced using PEG 3350 as a precipitant and high protein concentrations. Further optimization with a combination of additives led to the generation of SpaE crystals in an orthorhombic form that diffracted to a higher resolution of 1.5 Å. To expedite structure determination by SAD phasing, selenium-substituted (orthorhombic) SpaE crystals were grown and X-ray diffraction data were collected to 1.8 Å resolution.

  15. Characteristics of thermal-mineral waters in Backa region (Vojvodina) and their exploitation in spa tourism

    Energy Technology Data Exchange (ETDEWEB)

    Kosic, Kristina; Pivac, Tatjana; Romelic, Jovan; Lazic, Lazar; Stojanovic, Vladimir [Faculty of Science, Department of Geography, Tourism and Hotel Management, University of Novi Sad, Trg Dositeja Obradovica 3, 21000 Novi Sad (RS)

    2011-01-15

    Hydropower, biomass, biogas, biofuels, wind power, solar energy and geothermal energy are the major resources to provide Backa region with most of its. Backa extends between 45 16' and 46 22' of the northern latitude and 18 36' and 20 37' of the eastern longitude. It occupies the north-eastern part of Vojvodina, i.e. the most north-western part of the Republic of Serbia. That is historical-geographic territory bordered on the Danube on its western and eastern side, the Tisa on its eastern side and with the state border towards Hungary on the north. In this paper, the focus will be on renewable sources, specifically geothermal energy in Backa region. The paper analyzes the characteristics of thermal-mineral waters in Backa, the condition and possibilities of their exploitation in spa tourism, and in other economic branches. The tradition of thermo-mineral waters exploitation in spas and public baths is rather long. Today, this type of thermo-mineral waters exploitation in Backa is the widest spread. Permanent, i.e. continuous exploiters of thermal-mineral waters in Backa are primarily balneal-rehabilitation centres and exploiters using the water for technological purposes. (author)

  16. Determination of uranium and polonium in Spa rus aura ta by alpha spectrometry

    International Nuclear Information System (INIS)

    Luna P, M.; Renteria, M.; Montero C, M. E.; Manjon C, G.; Diaz, I.

    2012-01-01

    The aim of this study was optimizing conditions for the specific activities determination of some uranium-series radionuclides present in Spa rus aura ta by alpha spectrometry. Determinations of specific activities were conducted varying the type of digestion: acid attack on hot plate, controlled microwave digestion and acid attack after calcination of the sample. The latter procedure was applied only to the case of uranium isotopes determination. The variation in the isotope extraction method consisted of applying the techniques of liquid-liquid extracting using Tributyl phosphate or chromatographic UTEVA resin. Results depending on the type of treatment given to the samples were compared based on obtained chemical yields. The results reveal a higher bioaccumulation of polonium in the liver sample, with activities of 0.809, 2.495 and 2.439 Bq kg -1 fresh wt compared with the fillet. The best chemical yields of polonium were close to 60% for samples that were digested by microwave. In the case of uranium the best chemical yields, close to 80% for fillet, were obtained with a previous calcination of the sample and using the UTEVA resin. (Author)

  17. Determination of uranium and polonium in Spa rus aura ta by alpha spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Luna P, M.; Renteria, M.; Montero C, M. E. [Centro de Investigacion en Materiales Avanzados, S. C., Miguel de Cervantes No. 120, Complejo Industrial Chihuahua, 31109 Chihuahua (Mexico); Manjon C, G.; Diaz, I., E-mail: elena.montero@cimav.edu.mx [Universidad de Sevilla, Escuela Tecnica Superior de Arquitectura, Departamento de Fisica Aplicada II, San Fernando No. 4, 41004 Sevilla (Spain)

    2012-06-15

    The aim of this study was optimizing conditions for the specific activities determination of some uranium-series radionuclides present in Spa rus aura ta by alpha spectrometry. Determinations of specific activities were conducted varying the type of digestion: acid attack on hot plate, controlled microwave digestion and acid attack after calcination of the sample. The latter procedure was applied only to the case of uranium isotopes determination. The variation in the isotope extraction method consisted of applying the techniques of liquid-liquid extracting using Tributyl phosphate or chromatographic UTEVA resin. Results depending on the type of treatment given to the samples were compared based on obtained chemical yields. The results reveal a higher bioaccumulation of polonium in the liver sample, with activities of 0.809, 2.495 and 2.439 Bq kg{sup -1} fresh wt compared with the fillet. The best chemical yields of polonium were close to 60% for samples that were digested by microwave. In the case of uranium the best chemical yields, close to 80% for fillet, were obtained with a previous calcination of the sample and using the UTEVA resin. (Author)

  18. Hydrogeothermal resources in spa areas of Serbia: Main properties and possible improvement of use

    Directory of Open Access Journals (Sweden)

    Dokmanović Petar B.

    2012-01-01

    Full Text Available Geological complexity of the territory of Serbia is a world curiosity: six main geo-tectonic regions and tens sub-regions are delineated in a small area of 88,000 km2. Geologic origin and regional structure of some areas has long been the subject of discussion. Notable magmatism and associated tectonic events in the Earth's crust provided for a fairly large hydrogeothermal resource potential, which is manifested in more than 250 warm (mainly mineral springs and more than 100 hydrothermal wells. Thermal springs and wells together discharge some 5 m3/s. This potential is used in part for balneal therapy (waters differ in temperature and chemical composition in the spa areas of Serbia. The amounts of thermal water unused therapeutically or the amounts of heat energy from unused geo-thermal water may be used in almost all spas for space heating/cooling and thus increase the efficiency of the thermal water energy utilization. This also will be cost-effective, reduce emission of noxious gases, and improve the environmental-health image of the resorts. The hydrogeothermal resources are described for 29 spas with 700 l/s total discharge capacity of water temperature between 25°C and 96ºC, or an overall heat energy of 78.40 MWt. Feasibility of additional energy utilization of thermal water in spas is generally considered.

  19. Cellular uptake and processing of surfactant lipids and apoprotein SP-A by rat lung

    International Nuclear Information System (INIS)

    Young, S.L.; Wright, J.R.; Clements, J.A.

    1989-01-01

    The intracellular pathways and the kinetics of metabolism of surfactant apoprotein and lipid, which may be recycled from the alveolar space, are largely unknown. We used a lipid-apoprotein complex made from liposomes of pure lipids in a ratio found in mammalian pulmonary surfactant plus surfactant apoprotein (SP-A, Mr = 26,000-36,000) to test some possible relationships in the recycling of these major surfactant components between intrapulmonary compartments. After intratracheal instillation of 80 microliters of an apoprotein-liposome mixture with separate radiolabels in the lipid and the apoprotein, rats were killed at times from 8 min to 4 h later. The lungs were lavaged with saline, and subcellular fractions were isolated on discontinuous sucrose density gradients. Both the [ 14 C]lipid radiolabel and the 125 I-apoprotein radiolabel demonstrated a time-dependent increase in radioactivity recovered in a lamellar body-enriched fraction. Uptake of the radiolabels into other subcellular fractions did not exhibit a clear-cut time dependence; more of the protein than the lipid radiolabel was found in the Golgi-rich and microsomal fractions. We conclude that both the lipid and apoprotein portions of lung surfactant are taken up by lung cells and are incorporated into secretory granules of the cells

  20. The role of open-air inhalatoria in the air quality improvement in spa towns

    Directory of Open Access Journals (Sweden)

    Aleksandra Burkowska-But

    2014-08-01

    Full Text Available Objectives: The present study was aimed at evaluating microbiological contamination of air in Ciechocinek and Ino­wro­cław – Polish lowland spa towns. Additionally, the impact of open-air inhalatoria on the quality of air was evaluated. Material and Methods: Air samples were collected seasonally in the urban areas, in the recreation areas and in the vicinity of inhalatoria in both towns using impaction. The numbers of mesophilic bacteria, staphylococci, hemolytic bacteria and actinomycetes were determined on media according to the Polish Standard PN-86/Z-04111/02. The number of moulds was determined on media according to the Polish Standard PN-86/Z-04111/03. Results: While the highest numbers of microorganisms were noted at the sites located in the urban areas, the lowest numbers were noted in the vicinity of the open-air inhalatoria. In all the investigated air samples the values of bioaerosol concentrations were below the recommended TLVs (≤ 5000 CFU×m–3 for both bacteria and fungi in outdoor environments. Location of the sampling site was invariably a decisive factor in determining the number of microorganisms in the air. Conclusions: The aerosol which is formed in the open-air inhalatoria has a positive influence on microbiological air quality. Owing to a unique microclimate and low air contamination, Ciechocinek and Inowrocław comply with all necessary requirements set for health resorts specializing in treating upper respiratory tract infections.

  1. Superimposed versus residual basin: The North Yellow Sea Basin

    Directory of Open Access Journals (Sweden)

    Wenyong Li

    2012-01-01

    Full Text Available The North Yellow Sea Basin is a Mesozoic and Cenozoic basin. Based on basin-margin facies, sedimentary thinning, size and shape of the basin and vitrinite reflectance, North Yellow Sea Basin is not a residual basin. Analysis of the development of the basin’s three structural layers, self-contained petroleum systems, boundary fault activity, migration of the Mesozoic–Cenozoic sedimentation centers, different basin structures formed during different periods, and superposition of a two-stage extended basin and one-stage depression basin, the North Yellow Sea Basin is recognized as a superimposed basin.

  2. Validation of the Spanish Version of the Eating Assessment Tool-10 (EAT-10spa) in Colombia. A Blinded Prospective Cohort Study.

    Science.gov (United States)

    Giraldo-Cadavid, Luis Fernando; Gutiérrez-Achury, Alejandra María; Ruales-Suárez, Karem; Rengifo-Varona, Maria Leonor; Barros, Camilo; Posada, Andrés; Romero, Carlos; Galvis, Ana María

    2016-06-01

    Dysphagia might affect 12 % of the general population, and its complications include pneumonia, malnutrition, social isolation, and death. No validated Spanish symptom survey exists to quantify dysphagia symptoms among Latin Americans. Therefore, we performed a prospective cohort study in a tertiary care university hospital to validate the Spanish version of the 10-Item Eating-Assessment-Tool (EAT-10spa) for use in Colombia. After an interdisciplinary committee of five bilingual specialists evaluated the EAT-10spa (translated and validated in Spain) and deemed it appropriate for the Colombian culture, its feasibility, reliability, validity, sensitivity to change, and diagnostic capacity were evaluated. As a reference standard, we used the flexible endoscopic evaluation of swallowing with sensory testing and a standardized clinical evaluation. All assessments were blinded. In total, 133 subjects were included (52 % women, mean age 55 years) and completed the EAT-10spa (median completion time: 2 min [IQR 1-3 min]), 39 % of whom had an elementary-level education. Cronbach's α coefficient: 0.91; test-retest intra-class correlation coefficient: 0.94. The Spearman's correlation coefficient of the EAT-10spa with the 8-point penetration-aspiration scale was 0.54 (P EAT-10spa ≥2 (sensitivity 93.6 %, specificity 36.4 %) and EAT-10spa ≥4 (sensitivity 94.3 %, specificity 49.5 %), respectively. A reduction in the EAT-10 ≥3 was the best cut-off point for a clinically significant improvement (AUC-ROC 0.83; P EAT-10spa showed excellent psychometric properties and discriminatory capacity for use in Colombia.

  3. Genomic and Functional Characterization of the Unusual pLOCK 0919 Plasmid Harboring the spaCBA Pili Cluster in Lactobacillus casei LOCK 0919

    Science.gov (United States)

    Aleksandrzak-Piekarczyk, Tamara; Koryszewska-Bagińska, Anna; Grynberg, Marcin; Nowak, Adriana; Cukrowska, Bożena; Kozakova, Hana; Bardowski, Jacek

    2016-01-01

    Here, we report the extensive bioinformatic and functional analyses of the unusual pLOCK 0919, a plasmid originating from the probiotic Lactobacillus casei LOCK 0919 strain. This plasmid is atypical because it harbors the spaCBA-srtC gene cluster encoding SpaCBA pili. We show that all other spaCBA-srtC sequences of the Lactobacillus genus that have been previously described and deposited in GenBank are present in the chromosomal DNA. Another important observation for pLOCK 0919 is that the spaCBA-srtC gene cluster and its surrounding genes are highly similar to the respective DNA region that is present in the most well-known and active SpaCBA pili producer, the probiotic Lactobacillus rhamnosus GG strain. Our results demonstrate that the spaCBA-srtC clusters of pLOCK 0919 and L. rhamnosus GG are genealogically similar, located in DNA regions that are rich in transposase genes and are poorly conserved among the publicly available sequences of Lactobacillus sp. In contrast to chromosomally localized pilus gene clusters from L. casei and Lactobacillus paracasei, the plasmidic spaC of L. casei LOCK 0919 is expressed and undergoes a slight glucose-induced repression. Moreover, results of series of in vitro tests demonstrate that L. casei LOCK 0919 has an adhesion potential, which is largely determined by the presence of the pLOCK 0919 plasmid. In particular, the plasmid occurrence positively influenced the hydrophobicity and aggregation abilities of L. casei LOCK 0919. Moreover, in vivo studies indicate that among the three Lactobacillus strains used to colonize the gastrointestinal tract of germ-free mice, already after 2 days of colonization, L. casei LOCK 0919 became the dominant strain and persisted there for at least 48 days. PMID:26637469

  4. Major results and lessons learned for performance assessments of spent fuel geological disposal: the SPA project

    International Nuclear Information System (INIS)

    Baudoin, P.; Serres, C.; Certes, C.; Gay, D.

    2001-01-01

    This paper presents a summary of the results obtained in the framework of the SPA (spent fuel disposal performance assessment) project. The project was undertaken by ENRESA, E; GRS, D; IPSN, F; NRG, NL; SCK.CEN, B and VTT, FIN between May 1996 and April 1999. Devoted to the study of spent fuel disposal in various host rock formations (clay, crystalline rocks and salt formation), it notably had the objective to evaluate the long-term performance of different repository systems and to identify the most influential elements. The variety of concepts, sites and scenarios considered in the framework of this project provides a wide range of information from which some general conclusions can be drawn. Focusing on the work done in the case of granite host rock formations, this paper describes the various approaches adopted and states the main sources of differences. It particularly stresses the differences related to the geosphere and biosphere modelling. For the geosphere modelling, ENRESA, GRS and VTT use one dimensional discrete approaches to model the migration of contaminants through the geosphere taking into account for matrix diffusion, whereas IPSN uses a three dimensional continuum approach based on a single porosity model. The comparison of the biosphere conversion factors shows the high influence on the calculated radionuclide dose contributions that can results from biosphere modelling assumptions. It notably points out the differences existing between a simplified ''water drinking'' approach as implemented by VTT and a more classical one in which a wider range of exposure pathways are taken into account. (orig.)

  5. Spent fuel performance assessment (SPA) for a hypothetical repository in crystalline formations in Germany

    International Nuclear Information System (INIS)

    Luehrmann, L.; Noseck, U.; Storck, R.

    2000-07-01

    Within the framework of this project a first long-term safety assessment study for a generic German repository with spent nuclear fuel in granite host formations has been performed. Conceptual models have been developed and implemented into the numerical codes. These models describe the relevant processes in the near and far field of the repository. For the nuclide mobilisation and the diffusion-controlled transport through the bentonite barrier the computer code GRAPOS for far-field transport the code CHETMAD has been developed. Transport in the far field has been assumed to take place in a fracture network. As retardation mechanism matrix diffusion accompanied by linear equilibrium sorption on the rock matrix is considered. Both codes have been tested by intercomparison with codes of other countries. The dose rates have been calculated by the code EXCON considering the transport pathways into the biosphere. A reference scenario has been defined. It considers instantaneous saturation of the bentonite immediately after the operational phase of the repository, failure of all containers after 1000 years, diffusion through the bentonite, transport through fractured dykes, which represent a fast transport pathway in the low permeability region of the granite. The nuclide mobilization has been calculated according to a common source term which has been developed by all participants of the SPA project. It is assumed that 25% of the containers are connected to the considered transport pathway in the far field. The nuclides are transported to layers close to the surface. The contaminated water is pumped from a surface well and used for drinking, irrigation, cattle feed and fish ponds. (orig.) [de

  6. SPA AND CLIMATIC RESORTS (CENTERS AS RESOURCES OF PROGRAM OF SPORT RECREATION IMPLEMENTATION

    Directory of Open Access Journals (Sweden)

    Ivica Nikolić

    2006-06-01

    Full Text Available The aspiration of the civilized man is the improvement of work which aim is to achieve as big as possible effect of productivity and as small as possible participation of labour. The result of this process, which cannot be avoided, is some kind of fatigue that has hypocinaesiological characteristics in regard to demands of modern work process. The most effective way to fight against fatigue is to have an active holiday that is meaningfully programmed, led and carried out through movement of tourists, with the addition of natural factors, among which climate and healing waters are particularly important. These very resources characterize the tourist potential of Serbia and Montenegro with lots of available facilities at 1000 m height above the sea level and spa centers with springs and a complete offer physio-prophylactic procedures and following facilities for sport recreation. The implementation of programmed active holidays in to the corpus of tourist offer of Serbia and Montenegro represents prospective of development of tourism and tourist economy with effects of multiple importance as for participants, so for the level of tourist consumption. That will definitely influence the lengthening of tourist season as the primary goal of every catering establishment. Surveys show that the affection and viewpoints of potential tourists are especially directed towards engaging sport games and activities on and in the water, as part of the elementary tourist offer in spas and climatic resorts and their available facilities. Recommendationsand postulates of program of sport recreation, which are presented through four charts, are the basis of marketing strategy of appearance on tourist market with permanent education of management personnel and further research of potential market expanding. The publication and distribution of advertising materials are especially important, both at the market in our country and at the foreign market, where the abundance

  7. Treatment of knee OSTEOARTHRITIS in Spa Health resorts: where do we stand?

    Directory of Open Access Journals (Sweden)

    Salca Amalia

    2015-09-01

    Full Text Available Osteoarthrosis (OA includes degenerative joint disorders that affect articular cartilage in the first instance, followed by changes of all components of the joint. The disease is detected in a proportion of 33% by X-ray in patients aged over 60 years. Knee OA (KOA ranks first among chronic diseases from the point of view of patient disability. This article is a review of guidelines and articles regarding arthrosis, balneotherapy, and balneotherapy in KOA treatment. These were accessed on the Pubmed site in the period March-April 2015. The components of balneo-therapy to which the selected articles refer include mud packs, mineral waters, climate change. These are evaluated in association or in comparison with other methods used in the rehabilitation specialty area for the treatment of KOA: kinesitherapy, intra-articular infiltrations, hydrothermotherapy. The changes induced by these therapies on clinical evolution (pain relief, tenderness, functionality, quality of life, depression symptoms or certain serum parameters (biomarkers of oxidative stress, inflammation and cartilage destruction, vitamin D and other serum metabolites were recorded. The results of our review are consistent with the studies focused on spa modalities in all types of OA. All these data helped defining the role of balneotherapy as part of the rehabilitation program for the treatment of KOA, through the benefits specific to it. Conclusion: Balneotherapy has beneficial effects on patients with KOA, both clinically and serologic improvements. Further studies are needed to quantify these effects using KOA specific markers, to establish a hierarchy of balneotherapy methods based on their effects on KOA, as well as to refine indications depending on the stage of the disease.

  8. Analysis of the radioactivity in the 'Elguea' spa, Villa Clara, Cuba; Analisis de la radiactividad en el balneario 'Elguea' , Villa Clara, Cuba

    Energy Technology Data Exchange (ETDEWEB)

    Fernandez G, I.M.; Zerquera, J.T.; Carrazana G, J.; Capote F, E.; Rodriguez C, G. [CPHR, La Habana (Cuba)]. e-mail: isis@cphr.edu.cu

    2006-07-01

    The 'Elguea' spa, located in the north coast of the county of Villa Clara, Cuba, is considered one of those more important spas of Latin America. The waters of this spa are rich in salts of chlorine, sodium, bromine, sulfides and its contain radon. As a result of measurements of environmental gamma dose rates carried out in the area of the spa, its were considered levels of dose between 0.13 and 2.3 mSv. The obtained results motivated that it was carried out a characterization, from the radiological point of view, of the spa. This characterization is of supreme importance to be able to evaluate the impact that it has and the discharges of its waters on the environment, as well as, those dose that the population potentially affected can receive by these discharges. With this end its were carried out quantitative determinations of those existent natural more significant radionuclides in different environmental objects coming from the area of the spa and its surroundings, as well as one characterization gamma 'in situ' of the same one. The obtained results are present in this work. (Author)

  9. Lactobacillus rhamnosus GG and its SpaC pilus adhesin modulate inflammatory responsiveness and TLR-related gene expression in the fetal human gut

    Science.gov (United States)

    Ganguli, Kriston; Collado, Maria Carmen; Rautava, Jaana; Lu, Lei; Satokari, Reetta; von Ossowski, Ingemar; Reunanen, Justus; de Vos, Willem M.; Palva, Airi; Isolauri, Erika; Salminen, Seppo; Walker, W. Allan; Rautava, Samuli

    2015-01-01

    Background Bacterial contact in utero modulates fetal and neonatal immune responses. Maternal probiotic supplementation reduces the risk of immune-mediated disease in the infant. We investigated the immunomodulatory properties of live Lactobacillus rhamnosus GG and its SpaC pilus adhesin in human fetal intestinal models. Methods TNF-α mRNA expression was measured by qPCR in a human fetal intestinal organ culture model exposed to live L. rhamnosus GG and proinflammatory stimuli. Binding of recombinant SpaC pilus protein to intestinal epithelial cells was assessed in human fetal intestinal organ culture and the human fetal intestinal epithelial cell line H4 by immunohistochemistry and immunofluorescence, respectively. TLR-related gene expression in fetal ileal organ culture after exposure to recombinant SpaC was assessed by qPCR. Results Live L. rhamnosus GG significantly attenuates pathogen-induced TNF-α mRNA expression in the human fetal gut. Recombinant SpaC protein was found to adhere to the fetal gut and to modulate varying levels of TLR-related gene expression. Conclusion The human fetal gut is responsive to luminal microbes. L. rhamnosus GG significantly attenuates fetal intestinal inflammatory responses to pathogenic bacteria. The L. rhamnosus GG pilus adhesin SpaC binds to immature human intestinal epithelial cells and directly modulates intestinal epithelial cell innate immune gene expression. PMID:25580735

  10. Investments in Recreational and Sports Infrastructure aS A Basis for the Development of Sports Tourism On the Example of Spa Municipalities

    Directory of Open Access Journals (Sweden)

    Hadzik Andrzej

    2014-07-01

    Full Text Available Introduction. Among the basic conditions for the development of tourism in spa municipalities, investments in different infrastructure, including recreational and sports facilities should be distinguished. The aim of this work was to show the scope and the financing of sports and recreational investments in selected spa municipalities in Poland. Material and methods. The article uses the diagnostic survey method. The surveys were carried out in June 2012 among the representatives of the selected spa municipalities with the use of a specially prepared questionnaire. Results. The municipalities covered in this research declared carrying out investments in recreational and sports infrastructure, most often in football pitches. During the survey the highest number of investments of this type were conducted in Kołobrzeg. Among other recreational and sports projects, one of the most popular was investing in cycling routes. The research on the sources of financing of investments in recreational and sports infrastructure shows that almost all municipalities declared using funds from their own income. Furthermore, most of the analyzed municipalities used resources from the European Union. Other sources of financing were not that popular. Conclusion. In the time of apparent competitiveness and globalization of the spa market, recreational and sports facilities are very important. The authors believe that sports tourism can be one of the forms of health tourism in spas. The conducted research of spa municipalities has proved that:

  11. Lactobacillus rhamnosus GG and its SpaC pilus adhesin modulate inflammatory responsiveness and TLR-related gene expression in the fetal human gut.

    Science.gov (United States)

    Ganguli, Kriston; Collado, Maria C; Rautava, Jaana; Lu, Lei; Satokari, Reetta; von Ossowski, Ingemar; Reunanen, Justus; de Vos, Willem M; Palva, Airi; Isolauri, Erika; Salminen, Seppo; Walker, W Allan; Rautava, Samuli

    2015-04-01

    Bacterial contact in utero modulates fetal and neonatal immune responses. Maternal probiotic supplementation reduces the risk of immune-mediated disease in the infant. We investigated the immunomodulatory properties of live Lactobacillus rhamnosus GG and its SpaC pilus adhesin in human fetal intestinal models. Tumor necrosis factor (TNF)-α mRNA expression was measured by qPCR in a human fetal intestinal organ culture model exposed to live L. rhamnosus GG and proinflammatory stimuli. Binding of recombinant SpaC pilus protein to intestinal epithelial cells (IECs) was assessed in human fetal intestinal organ culture and the human fetal intestinal epithelial cell line H4 by immunohistochemistry and immunofluorescence, respectively. TLR-related gene expression in fetal ileal organ culture after exposure to recombinant SpaC was assessed by qPCR. Live L. rhamnosus GG significantly attenuates pathogen-induced TNF-α mRNA expression in the human fetal gut. Recombinant SpaC protein was found to adhere to the fetal gut and to modulate varying levels of TLR-related gene expression. The human fetal gut is responsive to luminal microbes. L. rhamnosus GG significantly attenuates fetal intestinal inflammatory responses to pathogenic bacteria. The L. rhamnosus GG pilus adhesin SpaC binds to immature human IECs and directly modulates IEC innate immune gene expression.

  12. [Alfred Marcin Sokołowski and Władyslaw Matlakowski. Contribution to history of spa treatment of pulmonary tuberculosis].

    Science.gov (United States)

    Kierzek, Andrzej; Pozowski, Andrzej; Kuciel-Lewandowska, Jadwiga

    2007-01-01

    The professional, scientific and didactic careers of Alfred Marcin Sokołowski (1849-1924) and Władysław Matlakowski (1851-1895) are presented at the beginning. Sokołowski was an assistant and afterwards a deputy of the head of hospital department Herman Brehmer in health resort in Goerbersdorf. In 1880 Sokołowski organized the internal diseases ward and rhinolaryngological outpatient clinic at St. Spirit Hospital in Warsaw. Sokołowski published "Clinical lectures of diseases of respiratory tract" (1902-1906) and many scientific papers. He was a pioneer of Polish pulmonology, rhinolaryngology and spa treatment of respiratory tract diseases. He was a well-known social worker. Matlakowski, who was a surgeon of Surgical Clinic of Warsaw Emperor University and an assistant of Julian Kosiński specialized in abdominal surgery and gynaecologic surgery. While suffering from pulmonary tuberculosis he moved to Zakopane, where he became famous as an ethnographer, an author of two books: "Country architecture of the Tatra Highlands" and "Decoration and equipment of Polish people of the Tatra Highlands". He translated Shakespearian "Hamlet" into Polish. He was also a well-known philosopher and an ornithologist. The meeting of Sokołowski and Matlakowski in Goerbersdorf, and also their further acquaintance and friendship are described widely by the author. Their work at "Gazeta Lekarska" ("Medical Magazine's") editorial office, which was well-known in three sectors of partitioned Poland is presented with more details by the author. Finally the epitome of spa treatment of pulmonary tuberculosis is presented. Sokołowski and Matlakowski were propagators of spa treatment of pulmonary tuberculosis; Sokołowski made Goerbersdorf famous, Matlakowski did the same for Zakopane.

  13. Bone mineral density in women on long-term mud-bath therapy in a Salus per Aquam (SPA environment

    Directory of Open Access Journals (Sweden)

    A. Loi

    2013-07-01

    Full Text Available The objective of this study was to assess bone mineral density (BMD in women on long-term mud-bath therapy (MBT for osteoarthritis in a Salus per Aquam (SPA environment. Two hundred and fifty female patients were randomly enrolled in this study in the SPA center of Sardara (Cagliari, Italy where they were treated with a combination of daily full body mudpacks and bicarbonate-alkaline mineral water baths at cycles of 2 weeks/year. BMD was evaluated by means of calcaneus ultrasonometry (Sahara Hologic Inc., Bedford, MA, USA and results analyzed according to duration of treatment and clinical variables. In the group of patients undergoing MBT for more than 10 years (group A and for 3 to 10 years (group B a reduced frequency of osteopenia and osteoporosis was detected (35.8% and 7.6% group A; 38.4% and 8.5% group B, respectively compared to controls (group C (48.9% and 23.4%, P<0.01 and P<0.001. Furthermore, higher T-score values were detected in group A and B (-1.05±1.28 and -1.24±0.94, respectively compared to group C (-1.93±0.78 (P<0.0002 and P<0.0001. Similar results were observed in the analysis of data restricted to women in menopause only. Long-term mud-bath therapy in SPA environment appeared to be beneficial for BMD.

  14. Interaction between the Stress Phase Angle (SPA and the Oscillatory Shear Index (OSI Affects Endothelial Cell Gene Expression.

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    Ronny Amaya

    Full Text Available Hemodynamic forces play an important role in the non-uniform distribution of atherosclerotic lesions. Endothelial cells are exposed simultaneously to fluid wall shear stress (WSS and solid circumferential stress (CS. Due to variations in impedance (global factors and geometric complexities (local factors in the arterial circulation a time lag arises between these two forces that can be characterized by the temporal phase angle between CS and WSS (stress phase angle-SPA. Asynchronous flows (SPA close to -180° that are most prominent in coronary arteries have been associated with localization of atherosclerosis. Reversing oscillatory flows characterized by an oscillatory shear index (OSI that is great than zero are also associated with atherosclerosis localization. In this study we examined the relationship between asynchronous flows and reversing flows in altering the expression of 37 genes relevant to atherosclerosis development. In the case of reversing oscillatory flow, we observed that the asynchronous condition upregulated 8 genes compared to synchronous hemodynamics, most of them proatherogenic. Upregulation of the pro-inflammatory transcription factor NFκB p65 was confirmed by western blot, and nuclear translocation of NFκB p65 was confirmed by immunofluorescence staining. A comparative study between non-reversing flow and reversing flow found that in the case of synchronous hemodynamics, reversing flow altered the expression of 11 genes, while in the case of asynchronous hemodynamics, reversing flow altered the expression of 17 genes. Reversing flow significantly upregulated protein expression of NFκB p65 for both synchronous and asynchronous conditions. Nuclear translocation of NFκB p65 was confirmed for synchronous and asynchronous conditions in the presence of flow reversal. These data suggest that asynchronous hemodynamics and reversing flow can elicit proatherogenic responses in endothelial cells compared to synchronous

  15. Interaction between the Stress Phase Angle (SPA) and the Oscillatory Shear Index (OSI) Affects Endothelial Cell Gene Expression.

    Science.gov (United States)

    Amaya, Ronny; Cancel, Limary M; Tarbell, John M

    2016-01-01

    Hemodynamic forces play an important role in the non-uniform distribution of atherosclerotic lesions. Endothelial cells are exposed simultaneously to fluid wall shear stress (WSS) and solid circumferential stress (CS). Due to variations in impedance (global factors) and geometric complexities (local factors) in the arterial circulation a time lag arises between these two forces that can be characterized by the temporal phase angle between CS and WSS (stress phase angle-SPA). Asynchronous flows (SPA close to -180°) that are most prominent in coronary arteries have been associated with localization of atherosclerosis. Reversing oscillatory flows characterized by an oscillatory shear index (OSI) that is great than zero are also associated with atherosclerosis localization. In this study we examined the relationship between asynchronous flows and reversing flows in altering the expression of 37 genes relevant to atherosclerosis development. In the case of reversing oscillatory flow, we observed that the asynchronous condition upregulated 8 genes compared to synchronous hemodynamics, most of them proatherogenic. Upregulation of the pro-inflammatory transcription factor NFκB p65 was confirmed by western blot, and nuclear translocation of NFκB p65 was confirmed by immunofluorescence staining. A comparative study between non-reversing flow and reversing flow found that in the case of synchronous hemodynamics, reversing flow altered the expression of 11 genes, while in the case of asynchronous hemodynamics, reversing flow altered the expression of 17 genes. Reversing flow significantly upregulated protein expression of NFκB p65 for both synchronous and asynchronous conditions. Nuclear translocation of NFκB p65 was confirmed for synchronous and asynchronous conditions in the presence of flow reversal. These data suggest that asynchronous hemodynamics and reversing flow can elicit proatherogenic responses in endothelial cells compared to synchronous hemodynamics without

  16. Topographic Transmissions and How To Talk About Them: The Case of the Southern Spa in Nineteenth-Century Russian Fiction

    Directory of Open Access Journals (Sweden)

    Benjamin Morgan

    2014-10-01

    Full Text Available The Caucasian spa resort is a significant setting in Russian literature of the nineteenth century. This paper will trace the origins and evolution of Russian fictional writing about watering places like Piatigorsk and Kislovodsk from romanticism until the turn of the twentieth century. At the same time it will consider the semiotic theories of Iurii Lotman’s Tartu-Moscow School and the ‘transtextual’ apparatus of the French narratologist Gérard Genette as ‘toolboxes’ for work on place in narrative.

  17. [The spa-health resort and touristic-recreational facilities of the region: the methodological aspects of their development].

    Science.gov (United States)

    Kirilina, V M; Kolesnikova, N V; Kolesnikov, N G

    2016-01-01

    The correction and optimization of the motor activity of the patients are currently the main priorities of all rehabilitative and recreational activities based at the spa and health resort facilities. The forms of such activities include walking tours and excursion trips. In other words, the excursion potential is one of the very important attributes of the recreational recourses. Under the current conditions characterized by the rapid socio-economic changes, the studies concerning the structural and functional transformation of spa and health resorts, recreational and tourist facilities acquire special importance, both from the humanitarian and economic points of view. The results of these studies may greatly contribute to the organization and the further development of rehabilitative and recreational activities based at the spa and health resort facilities, recreational and tourist centers taking into consideration their evolution. The objective of the present article is to analyze the structure and functions of the recreation and tourist centres as well as the modes of their cooperation with the spa and health resort facilities. In other words, these structures and their functions are both the object and the subject of the present study. The methodology of the study is based on the logical analysis of the development of the recreational and tourist systems in the framework of the evolutionary approach. (1) the notions of «tourist destination» and «recreation» have been substantiated; (2) the results of the studies carried out at the Institute of Physical Culture, Sports and Tourism and the Petrozavodsk State University have been used to elaborate the affiliate international Master Degree program «Project management in the tourism industry». The main emphasis in this program is placed on the necessity and methods of the improvement of recreational activities and more efficacious utilization of the climatic factors and the health resort infrastructure as

  18. Impact of serum SP-A and SP-D levels on comparison and prognosis of idiopathic pulmonary fibrosis

    Science.gov (United States)

    Wang, Kai; Ju, Qing; Cao, Jing; Tang, Wenze; Zhang, Jian

    2017-01-01

    Abstract Background and objective: Idiopathic pulmonary fibrosis (IPF) has a poor prognosis in general; however, it is heterogeneous to detect relative biomarkers for predicting the disease progression. Serum biomarkers can be conveniently collected to detect and help to differentially diagnose IPF and predict IPF prognosis. This meta-analysis aimed to evaluate the use of serum surfactant proteins A and D (SP-A and SP-D) for differential diagnosis and prognosis of IPF. Methods: Relevant articles were searched in PubMed, Embase, and Chinese National Knowledge Infrastructure databases and reviewed by 2 independent readers. Standard mean difference (SMD) and 95% confidence interval (CI) were calculated to assess the difference in serum levels of SP-A/D among patients with IPF, when compared to patients with non-IPF interstitial lung disease (ILD), pulmonary infection, and healthy control. Hazard ratio (HR) and 95% CI were used to compare the relative risk of mortality. Results: Twenty-one articles (totalling 1289 IPF patients) were included in final meta-analysis. Serum SP-A levels were significantly higher in patients with IPF than in patients with non-IPF ILD (SMD: 1.108 [0.584, 1.632], P infection (SMD: 1.320 [0.999, 1.640], P SMD: 2.802 [1.901, 3.702], P SMD: 0.459 [−0.000, 0.919], P = .050). Serum SP-D levels were significantly higher in patients with IPF than in patients with pulmonary infection (SMD: 1.308 [0.813, 1.803], P SMD: 2.235 [1.739, 2.731], P < .001). Risk of death in patients with IPF and elevated serum SP-A was increased 39% compared to patients with low SP-A groups. Elevated SP-D increased risk by 111% when compared to low SP-D. In acute exacerbation of IPF, serum SP-A/D were higher than those in stable stage. The comparisons and prognosis might be different in Asian and Caucasian patients. Conclusions: Serum SP-A/D detection might be useful for differential diagnosis and prediction of survival in patients with IPF. PMID:28591049

  19. An impactor origin for lunar magnetic anomalies.

    Science.gov (United States)

    Wieczorek, Mark A; Weiss, Benjamin P; Stewart, Sarah T

    2012-03-09

    The Moon possesses strong magnetic anomalies that are enigmatic given the weak magnetism of lunar rocks. We show that the most prominent grouping of anomalies can be explained by highly magnetic extralunar materials from the projectile that formed the largest and oldest impact crater on the Moon: the South Pole-Aitken basin. The distribution of projectile materials from a model oblique impact coincides with the distribution of magnetic anomalies surrounding this basin, and the magnetic properties of these materials can account for the intensity of the observed anomalies if they were magnetized in a core dynamo field. Distal ejecta from this event can explain the origin of isolated magnetic anomalies far from this basin.

  20. Smooth pursuit adaptation (SPA exhibits features useful to compensate changes in the properties of the smooth pursuit eye movement system due to usage.

    Directory of Open Access Journals (Sweden)

    Suryadeep eDash

    2013-10-01

    Full Text Available Smooth-pursuit adaptation (SPA refers to the fact that pursuit gain in the early, still open-loop response phase of the pursuit eye movement can be adjusted based on experience. For instance, if the target moves initially at a constant velocity for approximately 100-200ms and then steps to a higher velocity, subjects learn to up-regulate the pursuit gain associated with the initial target velocity (gain-increase SPA in order to reduce the retinal error resulting from the velocity step. Correspondingly, a step to a lower target velocity leads to a decrease in gain (gain-decrease SPA. In this study we demonstrate that the increase in peak eye velocity during gain-increase SPA is a consequence of expanding the duration of the eye acceleration profile while the decrease in peak velocity during gain-decrease SPA results from reduced peak eye acceleration but unaltered duration. Furthermore, we show that carrying out stereotypical smooth pursuit eye movements elicited by constant velocity target ramps for several hundred trials (= test of pursuit resilience leads to a clear drop in initial peak acceleration, a reflection of oculomotor and/ or cognitive fatigue. However, this drop in acceleration gets compensated by an increase in the duration of the acceleration profile, thereby keeping initial pursuit gain constant. The compensatory expansion of the acceleration profile in the pursuit resilience experiment is reminiscent of the one leading to gain-increase SPA, suggesting that both processes tap one and the same neuronal mechanism warranting a precise acceleration/ duration trade-off. Finally, we show that the ability to adjust acceleration duration during pursuit resilience depends on the integrity of the oculomotor vermis (OMV as indicated by the complete loss of the duration adjustment following a surgical lesion of the OMV in one rhesus monkey we could study.

  1. Surfactant protein A (SP-A) and angiotensin converting enzyme (ACE) as early biomarkers for pulmonary edema formation in ventilated human lung lobes.

    Science.gov (United States)

    Gnadt, Mirjam; Kardziev, Boris; Schmidt, Michael; Högger, Petra

    2012-08-01

    Ex vivo perfused and ventilated lung lobes frequently develop pulmonary edema. We were looking for a suitable and early detectable biomarker in the perfusion fluid indicating lung cell damage and loss of tissue integrity in ventilated human lung lobes. Therefore, we elucidated whether surfactant protein A (SP-A) and angiotensin-converting enzyme (ACE) were measurable in the perfusion fluid and whether they were suitable indicators for edema formation occurring within the experimental time frame of 1-2 h. Patients (n = 39) undergoing a lobectomy, bilobectomy or pneumonectomy due to primary bronchial cell carcinoma were included in the studies. Lung lobes were extracorporally ventilated and perfused for up to 2 h. Two different perfusion fluids were used, plain perfusion buffer and perfusion buffer containing packed erythrocytes or buffy coats. Perfusion fluid samples were analyzed for SP-A and ACE using immunoassays served as perfusion fluids. SP-A and ACE concentrations were analyzed in fluid sample sets of 39 and 33 perfusion experiments, respectively. Degrees of edema formation were arbitrarily classified into three groups (≤ 29, 30-59, ≥ 60 % weight gain). The maximum increase of SP-A and ACE concentrations in the perfusate was significantly higher for more pronounced edemas in case of perfusions using a mixture of blood components and buffer. Interestingly, the time courses of ACE and SP-A were highly similar. We suggest that SP-A and ACE are promising early biochemical markers for the development for pulmonary edema formation in the ex vivo lung lobe perfusion.

  2. Molecular epidemiology of Staphylococcus aureus bacteremia in a single large Minnesota medical center in 2015 as assessed using MLST, core genome MLST and spa typing.

    Science.gov (United States)

    Park, Kyung-Hwa; Greenwood-Quaintance, Kerryl E; Uhl, James R; Cunningham, Scott A; Chia, Nicholas; Jeraldo, Patricio R; Sampathkumar, Priya; Nelson, Heidi; Patel, Robin

    2017-01-01

    Staphylococcus aureus is a leading cause of bacteremia in hospitalized patients. Whether or not S. aureus bacteremia (SAB) is associated with clonality, implicating potential nosocomial transmission, has not, however, been investigated. Herein, we examined the epidemiology of SAB using whole genome sequencing (WGS). 152 SAB isolates collected over the course of 2015 at a single large Minnesota medical center were studied. Staphylococcus protein A (spa) typing was performed by PCR/Sanger sequencing; multilocus sequence typing (MLST) and core genome MLST (cgMLST) were determined by WGS. Forty-eight isolates (32%) were methicillin-resistant S. aureus (MRSA). The isolates encompassed 66 spa types, clustered into 11 spa clonal complexes (CCs) and 10 singleton types. 88% of 48 MRSA isolates belonged to spa CC-002 or -008. Methicillin-susceptible S. aureus (MSSA) isolates were more genotypically diverse, with 61% distributed across four spa CCs (CC-002, CC-012, CC-008 and CC-084). By MLST, there was 31 sequence types (STs), including 18 divided into 6 CCs and 13 singleton STs. Amongst MSSA isolates, the common MLST clones were CC5 (23%), CC30 (19%), CC8 (15%) and CC15 (11%). Common MRSA clones were CC5 (67%) and CC8 (25%); there were no MRSA isolates in CC45 or CC30. By cgMLST analysis, there were 9 allelic differences between two isolates, with the remaining 150 isolates differing from each other by over 40 alleles. The two isolates were retroactively epidemiologically linked by medical record review. Overall, cgMLST analysis resulted in higher resolution epidemiological typing than did multilocus sequence or spa typing.

  3. Characterization of Staphylococcus aureus from distinct geographic locations in China: an increasing prevalence of spa-t030 and SCCmec type III.

    Directory of Open Access Journals (Sweden)

    Yong Chen

    Full Text Available Staphylococcus aureus belongs to one of the most common bacteria causing healthcare and community associated infections in China, but their molecular characterization has not been well studied. From May 2011 to June 2012, a total of 322 non-duplicate S. aureus isolates were consecutively collected from seven tertiary care hospitals in seven cities with distinct geographical locations in China, including 171 methicillin sensitive S. aureus (MSSA and 151 MRSA isolates. All isolates were characterized by spa typing. The presence of virulence genes was tested by PCR. MRSA were further characterized by SCCmec typing. Seventy four and 16 spa types were identified among 168 MSSA and 150 MRSA, respectively. One spa type t030 accounted for 80.1% of all MRSA isolates, which was higher than previously reported, while spa-t037 accounted for only 4.0% of all MRSA isolates. The first six spa types (t309, t189, t034, t377, t078 and t091 accounted for about one third of all MSSA isolates. 121 of 151 MRSA isolates (80.1% were identified as SCCmec type III. pvl gene was found in 32 MSSA (18.7% and 5 MRSA (3.3% isolates, with ST22-MSSA-t309 as the most commonly identified strain. Compared with non-epidemic MRSA clones, epidemic MRSA clones (corresponding to ST239 exhibited a lower susceptibility to rifampin, ciprofloxacin, gentamicin and trimethoprim-sulfamethoxazole, a higher prevalence of sea gene and a lower prevalence of seb, sec, seg, sei and tst genes. The increasing prevalence of multidrug resistant spa-t030 MRSA represents a major public health problem in China.

  4. Molecular epidemiology of Staphylococcus aureus bacteremia in a single large Minnesota medical center in 2015 as assessed using MLST, core genome MLST and spa typing.

    Directory of Open Access Journals (Sweden)

    Kyung-Hwa Park

    Full Text Available Staphylococcus aureus is a leading cause of bacteremia in hospitalized patients. Whether or not S. aureus bacteremia (SAB is associated with clonality, implicating potential nosocomial transmission, has not, however, been investigated. Herein, we examined the epidemiology of SAB using whole genome sequencing (WGS. 152 SAB isolates collected over the course of 2015 at a single large Minnesota medical center were studied. Staphylococcus protein A (spa typing was performed by PCR/Sanger sequencing; multilocus sequence typing (MLST and core genome MLST (cgMLST were determined by WGS. Forty-eight isolates (32% were methicillin-resistant S. aureus (MRSA. The isolates encompassed 66 spa types, clustered into 11 spa clonal complexes (CCs and 10 singleton types. 88% of 48 MRSA isolates belonged to spa CC-002 or -008. Methicillin-susceptible S. aureus (MSSA isolates were more genotypically diverse, with 61% distributed across four spa CCs (CC-002, CC-012, CC-008 and CC-084. By MLST, there was 31 sequence types (STs, including 18 divided into 6 CCs and 13 singleton STs. Amongst MSSA isolates, the common MLST clones were CC5 (23%, CC30 (19%, CC8 (15% and CC15 (11%. Common MRSA clones were CC5 (67% and CC8 (25%; there were no MRSA isolates in CC45 or CC30. By cgMLST analysis, there were 9 allelic differences between two isolates, with the remaining 150 isolates differing from each other by over 40 alleles. The two isolates were retroactively epidemiologically linked by medical record review. Overall, cgMLST analysis resulted in higher resolution epidemiological typing than did multilocus sequence or spa typing.

  5. Effect of variable frequency electromagnetic field on deposit formation in installations with geothermal water in Sijarinjska spa (Serbia

    Directory of Open Access Journals (Sweden)

    Stojiljković Dragan T.

    2011-01-01

    Full Text Available In this paper we have examined the effect of variable frequency electromagnetic field generated with a homemade device on deposit formation in installations with geothermal water from Sijarinjska Spa. The frequency alteration of the electromagnetic field in time was made by means of the sinusoidal and saw-tooth function. In laboratory conditions, with the flow of geothermal water at 0.015 l/s and temperature of 60 °C for 6 hours through a zig-zag glass pipe, a multiple decrease of total deposit has been achieved. By applying the saw-tooth and sinusoidal function, the decrease in contents of calcium and deposit has been achieved by 8 and 6 times, respectively. A device was also used on geothermal water installation in Sijarinjska Spa (Serbia, with the water flow through a 1'' diameter non-magnetic prochrome pipe at 0.15 l/s and temperature of 75 °C in a ten-day period. A significant decrease in total deposit and calcium in the deposit has also been achieved.

  6. AIR SEBAGAI ALAT PENGENDALI IKLIM MIKRO DALAM BANGUNAN Studi Kasus : Taman Sari Royal Heritage Spa, Hotel Sheraton Mustika Yogyakarta

    Directory of Open Access Journals (Sweden)

    Dyah Hendrawati

    2016-07-01

    Full Text Available Indonesia is a country with wet tropical climate has constraints in obtaining thermal comfort because of the high air temperature, high air humidity and lower air speed. Modification of the microclimate might be conducted by increasing the cooling effect in a passive manner. Water can be used as one of control strategy thermal to build the microclimate or to site. Water also played an important role in lowering temperature and raise humidity in a room in building.Taman Sari Royal Heritage Spa, which is located in Yogyakarta,is one of building that implementing water as thermal control by making pool in door. This research aims to understand the influence of water in controlling the micro climate and the anything influence it .This research uses the quantitative methods by conducting observation and measuring temperature and humidity directly to the research objects. Secondary data is needed in this research. There was also literature review on the stuff that supports research, and a literature study was also conducted. The research and analysis on the results shows that 1 .The room in Tamansari royal heritage spa still in comfort zone in thermal .2 .The volume of water affects temperatures and humidity room 3 .Distance is a significant factor.

  7. Wine Valley Inn: A mineral water spa in Calistoga, California. Geothermal-energy-system conceptual design and economic feasibility

    Energy Technology Data Exchange (ETDEWEB)

    1981-10-26

    The purpose of this study is to determine the engineering and economic feasibility for utilizing geothermal energy for air conditioning and service water heating at the Wine Valley Inn, a mineral water spa in Calistoga, California. The study evaluates heating, ventilating, air conditioning and water heating systems suitable for direct heat geothermal application. Due to the excellent geothermal temperatures available at this site, the mechanics and economics of a geothermally powered chilled water cooling system are evaluated. The Wine Valley Inn has the resource potential to have one of the few totally geothermal powered air conditioning and water heating systems in the world. This total concept is completely developed. A water plan was prepared to determine the quantity of water required for fresh water well development based on the special requirements of the project. An economic evaluation of the system is included to justify the added capital investment needed to build the geothermally powered mineral spa. Energy payback calculations are presented. A thermal cascade system is proposed to direct the geothermal water through the energy system to first power the chiller, then the space heating system, domestic hot water, the two spas and finally to heat the swimming pool. The Energy Management strategy required to automatically control this cascade process using industrial quality micro-processor equipment is described. Energy Management controls are selected to keep equipment sizing at a minimum, pump only the amount of geothermal water needed and be self balancing.

  8. Great Basin insect outbreaks

    Science.gov (United States)

    Barbara Bentz; Diane Alston; Ted Evans

    2008-01-01

    Outbreaks of native and exotic insects are important drivers of ecosystem dynamics in the Great Basin. The following provides an overview of range, forest, ornamental, and agricultural insect outbreaks occurring in the Great Basin and the associated management issues and research needs.

  9. Melo carboniferous basin

    International Nuclear Information System (INIS)

    Flossdarf, A.

    1988-01-01

    This report is about of the Melo carboniferous basin which limits are: in the South the large and high Tupambae hill, in the west the Paraiso hill and the river mountains, in the North Yaguaron river basin to Candidata in Rio Grande del Sur in Brazil.

  10. K Basin safety analysis

    International Nuclear Information System (INIS)

    Porten, D.R.; Crowe, R.D.

    1994-01-01

    The purpose of this accident safety analysis is to document in detail, analyses whose results were reported in summary form in the K Basins Safety Analysis Report WHC-SD-SNF-SAR-001. The safety analysis addressed the potential for release of radioactive and non-radioactive hazardous material located in the K Basins and their supporting facilities. The safety analysis covers the hazards associated with normal K Basin fuel storage and handling operations, fuel encapsulation, sludge encapsulation, and canister clean-up and disposal. After a review of the Criticality Safety Evaluation of the K Basin activities, the following postulated events were evaluated: Crane failure and casks dropped into loadout pit; Design basis earthquake; Hypothetical loss of basin water accident analysis; Combustion of uranium fuel following dryout; Crane failure and cask dropped onto floor of transfer area; Spent ion exchange shipment for burial; Hydrogen deflagration in ion exchange modules and filters; Release of Chlorine; Power availability and reliability; and Ashfall

  11. Development of a Scintillation Proximity Assay (SPA) Based, High Throughput Screening Feasible Method for the Identification of PDE12 Activity Modulators.

    Science.gov (United States)

    Mang, Samuel; Bucher, Hannes; Nickolaus, Peter

    2016-01-01

    The scintillation proximity assay (SPA) technology has been widely used to establish high throughput screens (HTS) for a range of targets in the pharmaceutical industry. PDE12 (aka. 2'- phosphodiesterase) has been published to participate in the degradation of oligoadenylates that are involved in the establishment of an antiviral state via the activation of ribonuclease L (RNAse-L). Degradation of oligoadenylates by PDE12 terminates these antiviral activities, leading to decreased resistance of cells for a variety of viral pathogens. Therefore inhibitors of PDE12 are discussed as antiviral therapy. Here we describe the use of the yttrium silicate SPA bead technology to assess inhibitory activity of compounds against PDE12 in a homogeneous, robust HTS feasible assay using tritiated adenosine-P-adenylate ([3H]ApA) as substrate. We found that the used [3H]ApA educt, was not able to bind to SPA beads, whereas the product [3H]AMP, as known before, was able to bind to SPA beads. This enables the measurement of PDE12 activity on [3H]ApA as a substrate using a wallac microbeta counter. This method describes a robust and high throughput capable format in terms of specificity, commonly used compound solvents, ease of detection and assay matrices. The method could facilitate the search for PDE12 inhibitors as antiviral compounds.

  12. Methicillin-Resistant Staphylococcus aureus spa Type t002 Outbreak in Horses and Staff at a Veterinary Teaching Hospital after Its Presumed Introduction by a Veterinarian.

    Science.gov (United States)

    Steinman, Amir; Masarwa, Samira; Tirosh-Levy, Sharon; Gleser, Dan; Kelmer, Gal; Adler, Amos; Carmeli, Yehuda; Schwaber, Mitchell J

    2015-09-01

    Methicillin-resistant Staphylococcus aureus (MRSA) infection and colonization, involving MRSA strains which differ from common human health care-associated clones, have become serious emerging conditions in equine veterinary hospitals. In 2010, MRSA spa type t535 caused an outbreak involving both horses and personnel in a veterinary teaching hospital in Israel. Since then, surveillance continued, and occasional MRSA isolation occurred. Two years later, MRSA of another spa type, t002, was isolated from a veterinarian and, 3 weeks later, from a horse. The appearance of spa type t002, a common clone in human medicine in Israel, among both personnel and horses, prompted a point-prevalence survey of hospital personnel and hospitalized horses. Fifty-nine staff members (n = 16 equine; n = 43, other) and 14 horses were screened. Ten of 59 staff members (16.9%) and 7 of 14 horses (50%) were MRSA carriers. Among the staff, 44% of large animal department (LAD) personnel, compared with only 7% of non-LAD personnel, were carriers. Isolates from all horses and from 9 of 10 personnel were found to be of MRSA spa type t002. This clone was later isolated from an infected postoperative wound in a hospitalized horse. Measures were taken to contain transmission between horses and personnel, as was done in the previous outbreak, resulting in reduction of transmission and, finally, cessation of cross-transmission between horses and personnel. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

  13. Karhunen-Loève-Based Reduced-Complexity Representation of the Mixed-Density Messages in SPA on Factor Graph and Its Impact on BER

    Directory of Open Access Journals (Sweden)

    Prochazka Pavel

    2010-01-01

    Full Text Available The sum product algorithm on factor graphs (FG/SPA is a widely used tool to solve various problems in a wide area of fields. A representation of generally-shaped continuously valued messages in the FG/SPA is commonly solved by a proper parameterization of the messages. Obtaining such a proper parameterization is, however, a crucial problem in general. The paper introduces a systematic procedure for obtaining a scalar message representation with well-defined fidelity criterion in a general FG/SPA. The procedure utilizes a stochastic nature of the messages as they evolve during the FG/SPA processing. A Karhunen-Loève Transform (KLT is used to find a generic canonical message representation which exploits the message stochastic behavior with mean square error (MSE fidelity criterion. We demonstrate the procedure on a range of scenarios including mixture-messages (a digital modulation in phase parametric channel. The proposed systematic procedure achieves equal results as the Fourier parameterization developed especially for this particular class of scenarios.

  14. High frequency of methicillin-resistant Staphylococcus aureus (MRSA) with SCCmec type III and spa type t030 in Karaj's teaching hospitals, Iran.

    Science.gov (United States)

    Bayat, Bahareh; Zade, Masoumeh Hallaj; Mansouri, Samaneh; Kalantar, Enayat; Kabir, Kourosh; Zahmatkesh, Ehsan; Sepehr, Mohammad Noori; Naseri, Mohammmad Hassan; Darban-Sarokhalil, Davood

    2017-09-01

    Methicillin-resistant Staphylococcus aureus (MRSA) has been one of the most important antibiotic-resistant pathogen in many parts of the world over the past decades. This cross-sectional study was conducted to investigate MRSA isolated between July 2013 and July 2014 in Karaj, Iran. All tested isolates were collected in teaching hospitals from personnel, patients, and surfaces and each MRSA was analyzed by SCCmec and spa typing. Antibiotic susceptibility testing was accomplished by disk diffusion method. Out of 49 MRSA isolates from the Karaj's teaching hospitals, 82%, 10%, and 6% of the isolates were SCCmec types III, II, and I, respectively. The main spa type in this study was spa t030 with frequency as high as 75.5% from intensive care unit (ICU) of the hospitals and high rate of resistance to rifampicin (53%) was found in MRSA isolates. In conclusion, high frequency of spa t030 with SCCmec type III and MRSA phenotype illustrated circulating of one of the antibiotic-resistant strains in ICU of Karaj's teaching hospitals and emphasizes the need for ongoing molecular surveillance, antibiotic susceptibility monitoring, and infection control.

  15. Characterization of SCCmec and spa types of methicillin-resistant Staphylococcus aureus isolates from health-care and community-acquired infections in Kerman, Iran.

    Science.gov (United States)

    Fasihi, Yaser; Kiaei, Somayeh; Kalantar-Neyestanaki, Davood

    2017-12-01

    Spread of methicillin-resistant Staphylococcus aureus (MRSA) isolates is a worldwide problem. Molecular typing is a useful tool to understand MRSA epidemiology. Herein, we determined vancomycin-resistant, SCCmec and spa types among MRSA isolates recovered from healthcare and community-acquired infections in Kerman, Iran. A total of 170 S. aureus isolates were collected from different patients who were admitted to affiliated hospitals of Kerman University of Medical science. MRSA and vancomycin-resistant S. aureus (VRSA) isolates were detected by phenotypic methods. Polymerase chain reaction (PCR) technique was used for detection of mecA, vanA and vanB genes. Staphylococcal cassette chromosomemec (SCCmec) and spa typing were used for molecular typing of among MRSA isolates. Overall, 53% of isolates were considered as MRSA. Two MRSA isolates were resistant to vancomycin and vanA was detected in only one of VRSA isolates. SCCmec type III belonged to spa types t030 and t459 which they were the dominant spa types among community-associated MRSA (CA-MRSA) and healthcare-acquired MRSA (HA-MRSA) isolates. Our findings showed that the SCCmec type I and III spread from hospital settings to community, although the SCCmec type IV spread from community to healthcare systems. We have also reported VRSA isolates from hospitalized patients, therefore, appropriate policies should be enforced in order to prevent the spread of antibiotic resistance isolates in hospitals settings. Copyright © 2017 Ministry of Health, Saudi Arabia. Published by Elsevier Ltd. All rights reserved.

  16. Lactobacillus rhamnosus GG and its SpaC pilus adhesin modulate inflammatory responsiveness and TLR-related gene expression in the fetal human gut

    NARCIS (Netherlands)

    Ganguli, K.; Collado, M.C.; Rautava, J.; Lu, L.; Satokari, R.M.; Ossowski, von I.; Reunanen, J.; Vos, de W.M.; Palva, A.; Isolauri, E.; Salminen, S.; Walker, W.A.; Rautava, S.

    2015-01-01

    BACKGROUND: Bacterial contact in utero modulates fetal and neonatal immune responses. Maternal probiotic supplementation reduces the risk of immune-mediated disease in the infant. We investigated the immunomodulatory properties of live Lactobacillus rhamnosus GG and its SpaC pilus adhesin in human

  17. Progressive Increase in Disinfection By-products and Mutagenicity from Source to Tap to Swimming Pool and Spa Water: Impact of Human Use

    Science.gov (United States)

    Pools and spas are enjoyed throughout the world for exercise and relaxation. However, there are no previous studies on mutagenicity of disinfected spa (hot tub) waters or comprehensive identification of disinfection byproducts (DBPs) formed in spas. Using 28 water samples from ...

  18. Wada basin boundaries and basin cells

    NARCIS (Netherlands)

    Nusse, H.E.; Yorke, J.A.

    1996-01-01

    In dynamical systems examples are common in which two or more attractors coexist, and in such cases the basin boundary is nonempty. We consider a two-dimensional diffeomorphism F (that is, F is an invertible map and both F and its inverse are differentiable with continuous derivatives), which has at

  19. Solar-energy-system performance-evaluation update: Wood Road School, Ballston Spa, New York, October 1982-April 1983

    Energy Technology Data Exchange (ETDEWEB)

    Kendall, P

    1983-01-01

    The Wood Road School Solar Project is a 216,000 square foot combined elementary and middle school in Ballston Spa, New York. The solar energy system supplies energy to the space heating and domestic hot water subsystems. Heat is collected by flat plate collector panels and stored in two storage tanks. Performance data are given for the system overall and for each of the four subsystems - energy collection, storage, space heating, and domestic hot water. Data are also provided on operating energy, energy savings, and weather conditions. Design and actual system solar fraction are compared, and percentage of incident solar energy and collected solar energy utilized are given. Also given are building loads analysis, system thermal losses, and system coefficient of performance. (LEW)

  20. Effect of spring water on the radon concentration in the air at Masutomi spa in Yamanashi Prefecture, Japan

    International Nuclear Information System (INIS)

    Inagaki, Masayo; Koga, Taeko; Morishima, Hiroshige; Kimura, Shojiro; Ohta, Masatoshi

    2012-01-01

    The concentrations of 222 Rn existing in air have been studied by using a convenient and highly sensitive Pico-rad detector system at Masutomi spa in Yamanashi Prefecture, Japan. The measurements in air were carried out indoors and outdoors during the winter of 2000 and the summers of 1999 and 2005. The concentrations of 222 Rn in spring water in this region were measured by the liquid scintillation method. The concentrations of natural radionuclides contained in soils surrounding spa areas were also examined by means of the γ-ray energy spectrometry technique using a Ge diode detector to investigate the correlation between the radionuclides contents and 222 Rn concentrations in air at each point of interest. The atmospheric 222 Rn concentrations in these areas were high, ranging from 5 Bq/m 3 to 2676 Bq/m 3 . The radon concentration at each hotel was high in the order of the bath room, the dressing room, the lobby, and the outdoor area near the hotel, with averages and standard deviations of the concentration of 441 ± 79 Bq/m 3 , 351 ± 283 Bq/m 3 , 121 ± 5 Bq/m 3 , and 23 ± 1 Bq/m 3 , respectively. The source of 222 Rn in the air in the bath room is more likely to be the spring water than the soil. The spring water plays carries the radon to the atmosphere. Our measurements indicated that the 222 Rn concentration in the air was affected by the 222 Rn concentration in spring water rather than that in soil. (author)

  1. The protective effect of different airway humidification liquids to lung after tracheotomy in traumatic brain injury: The role of pulmonary surfactant protein-A (SP-A).

    Science.gov (United States)

    Su, Xinyang; Li, Zefu; Wang, Meilin; Li, Zhenzhu; Wang, Qingbo; Lu, Wenxian; Li, Xiaoli; Zhou, Youfei; Xu, Hongmei

    2016-02-10

    The purpose of this study was to establish a rat model of a brain injury with tracheotomy and compared the wetting effects of different airway humidification liquids, afterward, the best airway humidification liquid was selected for the clinical trial, thus providing a theoretical basis for selecting a proper airway humidification liquid in a clinical setting. Rats were divided into a sham group, group A (0.9% NaCl), group B (0.45% NaCl), group C (0.9% NaCl+ambroxol) and group D (0.9% NaCl+Pulmicort). An established rat model of traumatic brain injury with tracheotomy was used. Brain tissue samples were taken to determine water content, while lung tissue samples were taken to determine wet/dry weight ratio (W/D), histological changes and expression levels of SP-A mRNA and SP-A protein. 30 patients with brain injury and tracheotomy were selected and divided into two groups based on the airway humidification liquid instilled in the trachea tube, 0.45% NaCl and 0.9% NaCl+ambroxol. Blood was then extracted from the patients to measure the levels of SP-A, interleukin-6 (IL-6), interleukin-8 (IL-8) and tumour necrosis factor-α (TNF-α). The difference between group C and other groups in lung W/D and expression levels of SP-A mRNA and SP-A protein was significant (Phumidification liquid. Copyright © 2015 Elsevier B.V. All rights reserved.

  2. [The development of the medical information system for the improvement of the quality of work of the Crimean spa and health resorts].

    Science.gov (United States)

    Ezhov, V V; Grigor'ev, P E; Mizin, V I; Andriiashek, Iu I; Gol'dberg, D L; Olenchuk, A V

    2016-01-01

    The Crimea has the enormous potential for the health promotion activities. However, neither the profile of these activities nor the demand for the socio-medical services is clearly defined for the majority of the local spa and health resort facilities. The possibilities of modern information technology are not used in the full measure either. The objective of the present work was to elaborate the new medical information system and demonstrate its effectiveness. In addition, the article describes the main advantages of the system for the optimization of healthcare in the Crimean spa and health resort facilities. We reviewed and analyzed various literature publications, legal framework, standards, regulations, guidelines, and questionnaire survey data obtain at 50 spa and health resort facilities of the Crimea. The results of the assessment indicate the necessity of the systematic approach to the analysis of the quality of medical care and the process of its further development. Statistical and mathematical methods were used to elaborate the medical information system for the optimization of the activities of the Crimean spa and health resorts. The distinctive features of the proposed information system are modularity and the possibility of flexible adjustment to the conditions of individual settings, one-step data loading with the subsequent multiple application for the formulation of documents, automated filling of records in compliance with the medical standards, and taking into consideration the possible changes in or amendments to the form of the documents. The data obtained in the course of project implementation were used for the first time in the Republic of Crimea to design, substantiate, and recommend for the practical application the algorithm for the comprehensive estimation of the results of treatment of the patients based at the spa and health resort facilities with due regard for the specific regional conditions.

  3. High frequency of multidrug-resistant Staphylococcus aureus with SCCmec type III and Spa types t037 and t631 isolated from burn patients in southwest of Iran.

    Science.gov (United States)

    Parhizgari, Najmeh; Khoramrooz, Seyed Sajjad; Malek Hosseini, Seyed Ali Asghar; Marashifard, Masoud; Yazdanpanah, Mahboobeh; Emaneini, Mohammad; Gharibpour, Farzaneh; Mirzaii, Mehdi; Darban-Sarokhalil, Davood; Moein, Masoud; Naraki, Mahmood

    2016-03-01

    Methicilin resistance Staphylococcus aureus (MRSA) infections are the major challenges in hospitals, especially in the burn units. The use of molecular typing methods is essential for tracking the spread of S. aureus infection and epidemiological investigations. The aim of this study was to find the profile of the spa types and also the prevalence of each SCCmec type of S. aureus strains in a central burn hospital in southwest of Iran. A total of 81 non-duplicate S. aureus were isolated from burn patients between April 2011 and February 2012. The susceptibility of the isolates against 13 different antibiotics was tested by disk agar diffusion (DAD) method. MRSA strains were identified by amplification of mecA gene. Multiplex-polymerase chain reaction (PCR) technique was used to determine the SCCmec types of MRSA strains and all the S. aureus isolates were typed by spa typing method. Detection of mecA gene showed that 70 (86.4%) of the isolates were MRSA. The highest rate of resistance was observed for penicillin (97.5%) and erythromycin (77.8%). None of the isolates were resistant to vancomycin. Sixty-seven of the 70 MRSA isolates harbored only SCCmec type III and three untypeable isolates. Five different spa types were detected. The most common spa types were t037 (42.5%) and t631 (34.5%) and were only found in MRSA isolates. Only SCCmec type III was found in burn patients which emphasizes the HA-MRSA origin of these strains. Only five different spa types identified in this study are in accordance with one SCCmec type which indicates that a limited number of bacterial colons are circulated in the burn unit in this hospital. © 2015 APMIS. Published by John Wiley & Sons Ltd.

  4. California Air Basins

    Data.gov (United States)

    California Department of Resources — Air ResourcesCalifornia Air Resources BoardThe following datasets are from the California Air Resources Board: * arb_california_airbasins - California Air BasinsThe...

  5. BASINS Framework and Features

    Science.gov (United States)

    BASINS enables users to efficiently access nationwide environmental databases and local user-specified datasets, apply assessment and planning tools, and run a variety of proven nonpoint loading and water quality models within a single GIS format.

  6. Watershed Planning Basins

    Data.gov (United States)

    Vermont Center for Geographic Information — The Watershed Planning Basin layer is part of a larger dataset contains administrative boundaries for Vermont's Agency of Natural Resources. The dataset includes...

  7. K Basin Hazard Analysis

    International Nuclear Information System (INIS)

    PECH, S.H.

    2000-01-01

    This report describes the methodology used in conducting the K Basins Hazard Analysis, which provides the foundation for the K Basins Final Safety Analysis Report. This hazard analysis was performed in accordance with guidance provided by DOE-STD-3009-94, Preparation Guide for U. S. Department of Energy Nonreactor Nuclear Facility Safety Analysis Reports and implements the requirements of DOE Order 5480.23, Nuclear Safety Analysis Report

  8. K Basin Hazard Analysis

    Energy Technology Data Exchange (ETDEWEB)

    PECH, S.H.

    2000-08-23

    This report describes the methodology used in conducting the K Basins Hazard Analysis, which provides the foundation for the K Basins Final Safety Analysis Report. This hazard analysis was performed in accordance with guidance provided by DOE-STD-3009-94, Preparation Guide for U. S. Department of Energy Nonreactor Nuclear Facility Safety Analysis Reports and implements the requirements of DOE Order 5480.23, Nuclear Safety Analysis Report.

  9. K Basins Hazard Analysis

    International Nuclear Information System (INIS)

    WEBB, R.H.

    1999-01-01

    This report describes the methodology used in conducting the K Basins Hazard Analysis, which provides the foundation for the K Basins Safety Analysis Report (HNF-SD-WM-SAR-062/Rev.4). This hazard analysis was performed in accordance with guidance provided by DOE-STD-3009-94, Preparation Guide for U. S. Department of Energy Nonreactor Nuclear Facility Safety Analysis Reports and implements the requirements of DOE Order 5480.23, Nuclear Safety Analysis Report

  10. Hydrocode modeling of oblique impacts into terrestrial planets

    Science.gov (United States)

    Kendall, Jordan D.

    The abundance of moderately siderophile elements ("iron-loving"; e.g., Co, Ni) in the Earth's mantle is 10 to 100 times larger than predicted by chemical equilibrium between silicate melt and iron at low pressure, but it does match expectation for equilibrium at high pressure and temperature. Recent studies of differentiated planetesimal impacts assume that planetesimal cores survive the impact intact as concentrated masses that passively settle from a zero initial velocity and undergo turbulent entrainment in a global magma ocean; under these conditions, cores greater than 10 km in diameter do not fully mix without a sufficiently deep magma ocean. I have performed hydrocode simulations that revise this assumption and yield a clearer picture of the impact process for differentiated planetesimals possessing iron cores with radius = 100 km that impact into magma oceans. The impact process strips away the silicate mantle of the planetesimal and then stretches the iron core, dispersing the liquid iron into a much larger volume of the underlying liquid silicate mantle. Lagrangian tracer particles track the initially intact iron core as the impact stretches and disperses the core. The final displacement distance of initially closest tracer pairs gives a metric of core stretching. The statistics of stretching imply mixing that separates the iron core into sheets, ligaments, and smaller fragments, on a scale of 10 km or less. The impact dispersed core fragments undergo further mixing through turbulent entrainment as the molten iron fragments sink through the magma ocean and settle deeper into the planet. My results thus support the idea that iron in the cores of even large differentiated planetesimals can chemically equilibrate deep in a terrestrial magma ocean. The largest known impact on the Moon formed the South Pole-Aitken (SP-A) basin and excavated material as deep as the mantle. Here I suggest that large impacts eject enough material to cover the farside of the Moon

  11. Proceedings of international conference dedicated to the seventieth anniversary of Physical-technical institute, SPA 'Physics-Sun' 'Fundamental and applied problems of physics'

    International Nuclear Information System (INIS)

    Lutpullaev, S.L.; Atabaev, I.G.; Abdurakhmanov, A.A.

    2013-11-01

    The International conference dedicated to the seventieth anniversary of Physical-technical institute, SPA 'Physics-Sun' 'Fundamental and applied problems of physics' was held on 14-15 November, 2013 in Tashkent, Uzbekistan. Specialists discussed various aspects of modern problems of relativistic nuclear physics and physics of atomic nuclei, solid state physics, various applications of new materials. More than 225 talks were presented in the meeting. (k.m.)

  12. Comparison of spa types, SCCmec types and antimicrobial resistance profiles of MRSA isolated from turkeys at farm, slaughter and from retail meat indicates transmission along the production chain.

    Science.gov (United States)

    Vossenkuhl, Birgit; Brandt, Jörgen; Fetsch, Alexandra; Käsbohrer, Annemarie; Kraushaar, Britta; Alt, Katja; Tenhagen, Bernd-Alois

    2014-01-01

    The prevalence of MRSA in the turkey meat production chain in Germany was estimated within the national monitoring for zoonotic agents in 2010. In total 22/112 (19.6%) dust samples from turkey farms, 235/359 (65.5%) swabs from turkey carcasses after slaughter and 147/460 (32.0%) turkey meat samples at retail were tested positive for MRSA. The specific distributions of spa types, SCCmec types and antimicrobial resistance profiles of MRSA isolated from these three different origins were compared using chi square statistics and the proportional similarity index (Czekanowski index). No significant differences between spa types, SCCmec types and antimicrobial resistance profiles of MRSA from different steps of the German turkey meat production chain were observed using Chi-Square test statistics. The Czekanowski index which can obtain values between 0 (no similarity) and 1 (perfect agreement) was consistently high (0.79-0.86) for the distribution of spa types and SCCmec types between the different processing stages indicating high degrees of similarity. The comparison of antimicrobial resistance profiles between the different process steps revealed the lowest Czekanowski index values (0.42-0.56). However, the Czekanowski index values were substantially higher than the index when isolates from the turkey meat production chain were compared to isolates from wild boar meat (0.13-0.19), an example of a separated population of MRSA used as control group. This result indicates that the proposed statistical method is valid to detect existing differences in the distribution of the tested characteristics of MRSA. The degree of similarity in the distribution of spa types, SCCmec types and antimicrobial resistance profiles between MRSA isolates from different process stages of turkey meat production may reflect MRSA transmission along the chain.

  13. Comparison of spa Types, SCCmec Types and Antimicrobial Resistance Profiles of MRSA Isolated from Turkeys at Farm, Slaughter and from Retail Meat Indicates Transmission along the Production Chain

    Science.gov (United States)

    Vossenkuhl, Birgit; Brandt, Jörgen; Fetsch, Alexandra; Käsbohrer, Annemarie; Kraushaar, Britta; Alt, Katja; Tenhagen, Bernd-Alois

    2014-01-01

    The prevalence of MRSA in the turkey meat production chain in Germany was estimated within the national monitoring for zoonotic agents in 2010. In total 22/112 (19.6%) dust samples from turkey farms, 235/359 (65.5%) swabs from turkey carcasses after slaughter and 147/460 (32.0%) turkey meat samples at retail were tested positive for MRSA. The specific distributions of spa types, SCCmec types and antimicrobial resistance profiles of MRSA isolated from these three different origins were compared using chi square statistics and the proportional similarity index (Czekanowski index). No significant differences between spa types, SCCmec types and antimicrobial resistance profiles of MRSA from different steps of the German turkey meat production chain were observed using Chi-Square test statistics. The Czekanowski index which can obtain values between 0 (no similarity) and 1 (perfect agreement) was consistently high (0.79–0.86) for the distribution of spa types and SCCmec types between the different processing stages indicating high degrees of similarity. The comparison of antimicrobial resistance profiles between the different process steps revealed the lowest Czekanowski index values (0.42–0.56). However, the Czekanowski index values were substantially higher than the index when isolates from the turkey meat production chain were compared to isolates from wild boar meat (0.13–0.19), an example of a separated population of MRSA used as control group. This result indicates that the proposed statistical method is valid to detect existing differences in the distribution of the tested characteristics of MRSA. The degree of similarity in the distribution of spa types, SCCmec types and antimicrobial resistance profiles between MRSA isolates from different process stages of turkey meat production may reflect MRSA transmission along the chain. PMID:24788143

  14. Comparison of spa types, SCCmec types and antimicrobial resistance profiles of MRSA isolated from turkeys at farm, slaughter and from retail meat indicates transmission along the production chain.

    Directory of Open Access Journals (Sweden)

    Birgit Vossenkuhl

    Full Text Available The prevalence of MRSA in the turkey meat production chain in Germany was estimated within the national monitoring for zoonotic agents in 2010. In total 22/112 (19.6% dust samples from turkey farms, 235/359 (65.5% swabs from turkey carcasses after slaughter and 147/460 (32.0% turkey meat samples at retail were tested positive for MRSA. The specific distributions of spa types, SCCmec types and antimicrobial resistance profiles of MRSA isolated from these three different origins were compared using chi square statistics and the proportional similarity index (Czekanowski index. No significant differences between spa types, SCCmec types and antimicrobial resistance profiles of MRSA from different steps of the German turkey meat production chain were observed using Chi-Square test statistics. The Czekanowski index which can obtain values between 0 (no similarity and 1 (perfect agreement was consistently high (0.79-0.86 for the distribution of spa types and SCCmec types between the different processing stages indicating high degrees of similarity. The comparison of antimicrobial resistance profiles between the different process steps revealed the lowest Czekanowski index values (0.42-0.56. However, the Czekanowski index values were substantially higher than the index when isolates from the turkey meat production chain were compared to isolates from wild boar meat (0.13-0.19, an example of a separated population of MRSA used as control group. This result indicates that the proposed statistical method is valid to detect existing differences in the distribution of the tested characteristics of MRSA. The degree of similarity in the distribution of spa types, SCCmec types and antimicrobial resistance profiles between MRSA isolates from different process stages of turkey meat production may reflect MRSA transmission along the chain.

  15. AMIE Camera System on board SMART-1

    Science.gov (United States)

    Josset, J. L.; Beauvivre, S.; Amie Team

    The Advanced Moon micro-Imager Experiment AMIE on board ESA SMART-1 the first European mission to the Moon launched on 27th September 2003 is an imaging system with scientific technical and public outreach oriented objectives The science objectives are to image the Lunar Poles permanent shadow areas ice deposit eternal light crater rims ancient Lunar Non-mare volcanism local spectro-photometry and physical state of the lunar sur-face and to map high latitudes regions south mainly at far side South Pole Aitken basin The technical objectives are to perform a laserlink experiment detec-tion of laser beam emitted by ESA Tenerife ground station flight demonstration of new technologies and on-board autonomy navigation The public outreach and educational objectives are to promote planetary exploration We present the AMIE instrument and perfomances with respect to the first results

  16. First Results at the Moon from the SMART-1 / AMIE Experiment

    Science.gov (United States)

    Josset, J. L.; Beauvivre, S.; AMIE Team

    2005-08-01

    The Advanced Moon micro-Imager Experiment (AMIE), on board ESA SMART-1, the first European mission to the Moon (launched on 27th September 2003), is an imaging system with scientific, technical and public outreach oriented objectives. The science objectives are to image the Lunar South Pole, permanent shadow areas (ice deposit), eternal light (crater rims), ancient Lunar Non-mare volcanism, local spectro-photometry and physical state of the lunar surface, and to map high latitudes regions (south) mainly at far side (South Pole Aitken basin). The technical objectives are to perform a laserlink experiment (detection of laser beam emitted by ESA/Tenerife ground station), flight demonstration of new technologies and on-board autonomy navigation. The public outreach and educational objectives are to promote planetary exploration. We present here the first results obtained during the cruise phase and at the Moon.

  17. Science objectives and first results from the SMART-1/AMIE multicolour micro-camera

    Science.gov (United States)

    Josset, J.-L.; Beauvivre, S.; Cerroni, P.; de Sanctis, M. C.; Pinet, P.; Chevrel, S.; Langevin, Y.; Barucci, M. A.; Plancke, P.; Koschny, D.; Almeida, M.; Sodnik, Z.; Mancuso, S.; Hofmann, B. A.; Muinonen, K.; Shevchenko, V.; Shkuratov, Yu.; Ehrenfreund, P.; Foing, B. H.

    The Advanced Moon micro-Imager Experiment (AMIE), on-board SMART-1, the first European mission to the Moon, is an imaging system with scientific, technical and public outreach objectives. The science objectives are to image the lunar South Pole, permanent shadow areas (ice deposit), eternal light (crater rims), ancient lunar non-mare volcanism, local spectrophotometry and physical state of the lunar surface, and to map high latitudes regions (south) mainly at far side (South Pole Aitken basin). The technical objectives are to perform a Laserlink experiment (detection of laser beam emitted by ESA/Tenerife ground station), flight demonstration of new technologies and on-board autonomy navigation. The public outreach and educational objectives are to promote planetary exploration and space. We present here the first results obtained during the cruise phase.

  18. Co-brand strategy of evaluation of visual images in furniture design: Jimmy S.P.A. and STRAUSS as examples

    Science.gov (United States)

    Chen, Tien-Li; Pan, Fang-Ming; Tsai, Jen-Hui

    2013-03-01

    This study aimed to investigate the correlation of the image associated by the design Co-Brand (Jimmy S.P.A. and STRAUSS) and the impression perceived by subject of viewers. Visual images were used to examine the merit of the evaluation. The best result is provided using an object as an appropriate evaluation method. There are a lot of factors which influence to evaluation of a design. This study is limited to distinguish the appearance from Jimmy's picture books transform furniture and so on. Co-Brand of Jimmy S.P.A. and STRAUSS is not easy because there are not from the same cultural, and industry background and applying different marketing strategy, it is a way to combine the two brands by designing, used questionnaire of SD (Semantic differential evaluation) evaluation method to test out the perception of viewers, the objective of this study is to investigate and appraised the Co-Brands use by of the image in furniture from patrons. SD evaluation result showed, if design cannot understand the perception image of Jimmy S.P.A and STRAUSS with viewers mind, furniture design also can't transmit feeling with design.

  19. Historical analysis of rainfall-triggered rockfalls: the case study of the disaster of the ancient hydrothermal Sclafani Spa (Madonie Mts, northern-central Sicily, Italy) in 1851

    Science.gov (United States)

    Contino, Antonio; Bova, Patrizia; Esposito, Giuseppe; Giuffré, Ignazio; Monteleone, Salvatore

    2017-12-01

    In 1851, the region of Sicily experienced many rainstorm-induced landslides. On 13 March 1851, a rainstorm brought about a severe rockfall disaster near the small town of Sclafani (Madonie Mountains, northern-central Sicily, Italy). Rocks detached from the carbonate crest of Mt Sclafani (813 m above sea level) and fell downslope, causing the collapse of the ancient hydrothermal spa (about 430 m above sea level) and burying it. Fortunately, there were no injuries or victims. Given its geological, geomorphological and tectonic features, the calcareous-dolomitic and carbonate-siliciclastic relief of Mt Sclafani is extremely prone to landsliding. This study combines the findings of detailed geological and geomorphological field surveys and of a critical review of documentary data. A thorough analysis of documentary sources and historical maps made it possible to identify the location (previously unknown) of the ancient spa. The rockfall dynamics was reconstructed by comparing field reconnaissance data and documentary sources. The 1851 event reconstruction is an example of the application of an integrated methodological approach, which can yield a propaedeutic, yet meaningful picture of a natural disaster, paving the way for further research (e.g. slope failure susceptibility, future land-use planning, protection of thermal springs and mitigation of the impact of similar disasters in this area). Indeed, the intensification of extreme weather events, caused by global warming induced by climate change, has increased the risk of recurrence of a catastrophic event, like that of the ancient Sclafani spa, which is always a potential threat.

  20. Adjusting tourist destination marketing strategy according to the changes in the environment: Case study Bukovicka sSpa

    Directory of Open Access Journals (Sweden)

    Riznić Dejan T.

    2014-01-01

    Full Text Available Tourist destinations are compelled to create new business opportunities constantly in order to respond to the challenges that arise under the influence of a number of changes in the environment. Few of them are supporting the requirements for analyzing and creating a sustainable business and marketing strategies. The paper starts with the analysis of relevant theory and practice in decisionmaking and choosing the marketing strategy of the tourist destination, pointing to the importance of continuous adjustment of marketing strategy in order to improve the business performance and competitive advantage. A new approach to the design and management of market relations, as well as the need for adjusting marketing strategies to the changes in the environment, is presented in the case of Bukovacka Spa. In deciding, great emphasis is placed on the role and importance of innovation in marketing approaches as well as on the need to develop socially responsible marketing in order to improve its business performance and response to changes in the environment and more successfully positioning.

  1. Chemical composition of the thermomineral waters of Josanicka Banja spa as an origin indicator, balneological valorization and geothermal potential

    Directory of Open Access Journals (Sweden)

    Milenić Dejan R.

    2015-01-01

    Full Text Available The chemical composition of the groundwater is directly dependent on the geological structure, hydrogeological and hydrochemical characteristics and as such it represents an output result of all the factors and processes which take place in the environment within which they were formed. The chemical composition of thermomineral waters often represents a crucial factor in determining the origin, balneological valorization and geothermal potential of the resources. This work presents the analysis of origin, belneological valorization and geothermal potential of Josanicka Banja spa, on the basis of the results gained through making the analyisis of chemical contents of the thermomineral waters which occur in the area. The ratio of concentrations of specific chemical components in the thermomineral waters of Josanicka Banja has served as the basic tool for ascertaining the origin of these waters. On the basis of the analysis of the main anion-cation and gas compositions as well as the contents of specific micro-components, a balneological valorization of these resources has been carried out. Apart from that this work also presents the calculation of the expected temperatures in the primary geothermal reservoir, which was carried out on the basis of the results of chemical analysis of thermomineral waters that occur in the area. Geothermal potential of about 4 MWt and significant contents of balneologically active components of the chemical composition of these waters, open up a possibility for their multi-purpose use, which is also presented in the work. [Projekat Ministarstva nauke Republike Srbije, br. TR 33053

  2. Simulasi Penentuan Penempatan Filter Aktif Shunt Untuk Mendapatkan Distorsi Daya Yang Terkecil Di Blue Point Bay Villa & Spa

    Directory of Open Access Journals (Sweden)

    Antonius Ibi Weking

    2013-12-01

    Full Text Available Pengoperasian beban-beban nonlinear dapat menimbulkan distorsi harmonisa dalam bentuk gelombang tegangan dan arus yang mengakibatkan kondisi sistem kelistrikan tidak normal. Blue Point Bay Villa & Spa memiliki kandungan harmonisa yang tidak sesuai dengan standar IEEE 519-1992. Kandungan THD (Total Harmonics Distortion arus yang berlebih dapat menyebabkan kualitas daya sistem menjadi lebih buruk, sehingga menyebabkan faktor daya sistem menjadi lebih rendah. Filter aktif shunt berbasis inverter yang bertujuan untuk meredam harmonisa yang muncul. Dalam penelitian ini dilakukan simulasi penggunaan filter aktif menggunakan sofware simulink MATLAB, pengelompokkan jenis beban nonlinear, perhitungan daya aktif (P dan arus beban (IL, simulasi pada sistem sebelum dan sesudah penggunaan filter aktif, analisis daya distorsi (D, analisis THD hasil simulasi sesuai dengan IEEE 519-1992 yang ditentukan dan analisis penempatan filter aktif shunt yang tepat untuk menekan distorsi daya. Hasil analisis menunjukkan pemasangan filter aktif menyebabkan kandungan THD arus dan tegangan telah sesuai dengan IEEE 519-1992 yang ditentukan. Daya distorsi harmonisa pada sistem mengalami penurunan dan terjadi peningkatan faktor daya mendekati unity power factor pada feeder. Penempatan filter aktif shunt yang baik untuk menurunkan THD dan distorsi daya yaitu pada SDP 2 MDP 2 yaitu 7.551,23 VA.

  3. Áreas (desprotegidas do Brasil: as estâncias hidrominerais Protected areas in Brazil: Brazilian spa towns

    Directory of Open Access Journals (Sweden)

    Alessandra Bortoni Ninis

    2008-06-01

    Full Text Available Resumo: O presente texto discute a vulnerabilidade das estâncias hidrominerais brasileiras frente à expansão do mercado de águas minerais engarrafadas. Mostra como o isolamento entre as estâncias e as suas águas minerais, de um lado, e as políticas brasileiras de preservação ambiental, como a Política Nacional de Recursos Hídricos e a política de unidades de conservação, coloca em risco a sustentabilidade da produção hídrica, o turismo e os padrões de vida das comunidades residentes nestas estâncias.Abstract: The present paper discusses the vulnerability of Brazilian spa towns that depend on the extraction of mineral water, given the expansion of the market for bottled mineral water. It shows how the isolation of these communities and their sources of mineral water, on the one side, and the Brazilian environmental preservation policies (like the National Water Policy and the Conservation Units Policy, on the other, place risks to the sustainability of water production, to tourism and to the standards of living achieved by the communities depending on the extraction of mineral water.

  4. Manyame River Basin, Zimbabwe

    African Journals Online (AJOL)

    Available on website http://www.wrc.org.za. ISSN 1816-7950 (On-line) = Water SA Vol. 42 No. 1 January 2016. Published under a Creative Commons Attribution Licence. A test of the Lake Habitat Survey method in Cleveland Reservoir and. Lake Chivero (Manyame River Basin, Zimbabwe). Tatenda Dalu1*, Edwin ...

  5. The Mediterranean basin

    DEFF Research Database (Denmark)

    Tomas, Carmen; Sanchez Sanchez, Juan Jose; Barbaro, A.

    2008-01-01

    genetically from the rest of the populations in the Mediterranean area. This result supports the hypothesis of a low incidence of the south-north genetic interchange at the western shores of the Mediterranean basin. A low genetic distance was found between populations in the Middle East and the western part...

  6. Molecular characteristics of methicillin-resistant Staphylococcus aureus (MRSA) strains isolated from patients with bacteremia based on MLST, SCCmec, spa, and agr locus types analysis.

    Science.gov (United States)

    Goudarzi, Mehdi; Seyedjavadi, Sima Sadat; Nasiri, Mohammad Javad; Goudarzi, Hossein; Sajadi Nia, Raheleh; Dabiri, Hossein

    2017-03-01

    The widespread emergence of methicillin resistant Staphylococcus aureus, as a common cause of nosocomial infections, is becoming a serious concern in global public health. The objective of the present study was to investigate antimicrobial susceptibility pattern, frequency of virulence genes and molecular characteristics of methicillin-resistant Staphylococcus aureus strains isolated from patients with bacteremia. A total of 128 methicillin-resistant Staphylococcus aureus isolates were collected during February 2015 to January 2016. In vitro antimicrobial susceptibility of the isolates was assessed using the disk diffusion method. Conventional PCR was performed for the detection of adhesion (can, bbp, ebp, fnbB, fnbA, clfB, clfA) and toxin (etb, eta, pvl, tst) encoding genes, determining the agr type, SCCmec, MLST and spa typing of the isolates. All the methicillin-resistant Staphylococcus aureus isolates were found to be sensitive to linezolid, teicoplanin, and vancomycin. Resistance to the tested antibiotics varied from 97.7% for penicillin to 24.2% for mupirocin. The rate of multi drug resistance (MDR) in the present study was 97.7%. The most commonly detected toxin and adhesion genes were tst (58.6%), and clfB (100%), respectively. The majority of SCCmec III isolates were found in agr group I while SCCmec IV and II isolates were distributed among agr group III. Multilocus Sequence Typing (MLST) of the MRSA isolates showed five different sequence types: ST239 (43%), ST22 (39.8%), ST585 (10.9%), ST45 (3.9%) and ST240 (2.3%). All of the pvl positive strains belonged to ST22-SCCmec IV/t790 clone and were MDR. Among different 7 spa types, the most common were t790 (27.3%), t037 (21.9%), and t030 (14.1%). spa types t016, t924 and spa type t383 were reported for the first time from Asia and Iran, respectively. It was shown that spa types circulating in the studied hospitals varied which support the need to perform future surveillance studies in order to understand

  7. Canada Basin revealed

    Science.gov (United States)

    Mosher, David C.; Shimeld, John; Hutchinson, Deborah R.; Chian, D; Lebedeva-Ivanova, Nina; Jackson, Ruth

    2012-01-01

    More than 15,000 line-km of new regional seismic reflection and refraction data in the western Arctic Ocean provide insights into the tectonic and sedimentologic history of Canada Basin, permitting development of new geologic understanding in one of Earth's last frontiers. These new data support a rotational opening model for southern Canada Basin. There is a central basement ridge possibly representing an extinct spreading center with oceanic crustal velocities and blocky basement morphology characteristic of spreading centre crust surrounding this ridge. Basement elevation is lower in the south, mostly due to sediment loading subsidence. The sedimentary succession is thickest in the southern Beaufort Sea region, reaching more than 15 km, and generally thins to the north and west. In the north, grabens and half-grabens are indicative of extension. Alpha-Mendeleev Ridge is a large igneous province in northern Amerasia Basin, presumably emplaced synchronously with basin formation. It overprints most of northern Canada Basin structure. The seafloor and sedimentary succession of Canada Basin is remarkably flat-lying in its central region, with little bathymetric change over most of its extent. Reflections that correlate over 100s of kms comprise most of the succession and on-lap bathymetric and basement highs. They are interpreted as representing deposits from unconfined turbidity current flows. Sediment distribution patterns reflect changing source directions during the basin’s history. Initially, probably late Cretaceous to Paleocene synrift sediments sourced from the Alaska and Mackenzie-Beaufort margins. This unit shows a progressive series of onlap unconformities with a younging trend towards Alpha and Northwind ridges, likely a response to contemporaneous subsidence. Sediment source direction appeared to shift to the Canadian Arctic Archipelago margin for the Eocene and Oligocene, likely due to uplift of Arctic islands during the Eurekan Orogeny. The final

  8. Business Performance of Health Spa Tourism Providers in Relation to the Structure of Employees in the Republic of Croatia.

    Science.gov (United States)

    Vrkljan, Sanela; Grazio, Simeon

    2017-12-01

    Health spa tourism services are provided in special hospitals for medical rehabilitation and health resorts, and include controlled use of natural healing factors and physical therapy under medical supervision in order to improve and preserve health. Health tourism is a service industry and therefore labor-intensive industry in which human resources are one of the key factors of business success. The aim of this study was to analyze business performance of special hospitals for medical rehabilitation and health resorts in Croatia in relation to the structure of employees, specifically the number of physicians and total medical personnel, as well as the share of physicians and medical personnel in the total number of employees. The assumption was that those who employ more physicians and medical employees are more successful. The empirical research was conducted and the assumption was tested firstly by correlation analysis and afterwards by regression analysis. The total number of employees in the researched health resorts and special hospitals amounted to 2,863, of which the share of physicians specialists accounted for almost 7%, while the share of total medical staff was almost 53%. From the results of our research, it can be concluded that special hospitals for medical rehabilitation and health resorts, which employ more physicians and medical personnel, are achieving better financial business performance. Based on the results obtained, it is possible to provide guidance for further growth and development in the direction of basing the primary offer on medical-health offer, rather than on wellness offer, which is a strong trend in the world. These findings are important for planning the health and tourism policies in Croatia and similar countries.

  9. Integrated Hydrographical Basin Management. Study Case - Crasna River Basin

    Science.gov (United States)

    Visescu, Mircea; Beilicci, Erika; Beilicci, Robert

    2017-10-01

    Hydrographical basins are important from hydrological, economic and ecological points of view. They receive and channel the runoff from rainfall and snowmelt which, when adequate managed, can provide fresh water necessary for water supply, irrigation, food industry, animal husbandry, hydrotechnical arrangements and recreation. Hydrographical basin planning and management follows the efficient use of available water resources in order to satisfy environmental, economic and social necessities and constraints. This can be facilitated by a decision support system that links hydrological, meteorological, engineering, water quality, agriculture, environmental, and other information in an integrated framework. In the last few decades different modelling tools for resolving problems regarding water quantity and quality were developed, respectively water resources management. Watershed models have been developed to the understanding of water cycle and pollution dynamics, and used to evaluate the impacts of hydrotechnical arrangements and land use management options on water quantity, quality, mitigation measures and possible global changes. Models have been used for planning monitoring network and to develop plans for intervention in case of hydrological disasters: floods, flash floods, drought and pollution. MIKE HYDRO Basin is a multi-purpose, map-centric decision support tool for integrated hydrographical basin analysis, planning and management. MIKE HYDRO Basin is designed for analyzing water sharing issues at international, national and local hydrographical basin level. MIKE HYDRO Basin uses a simplified mathematical representation of the hydrographical basin including the configuration of river and reservoir systems, catchment hydrology and existing and potential water user schemes with their various demands including a rigorous irrigation scheme module. This paper analyzes the importance and principles of integrated hydrographical basin management and develop a case

  10. Drainage basins features and hydrological behaviour river Minateda basin

    International Nuclear Information System (INIS)

    Alonso-Sarria, F.

    1991-01-01

    Nine basin variables (shape, size and topology) have been analyzed in four small basins with non-permanent run off (SE of Spain). These geomorphological variables have been selected for their high correlation with the Instantaneous unit hydrograph parameters. It is shown that the variables can change from one small basin to another within a very short area; because of it, generalizations about the behaviour of the run off are not possible. In conclusion, it is stated that the variations in geomorphological aspects between different basins, caused mainly by geological constraints, are a very important factor to be controlled in a study of geoecological change derived from climatic change

  11. Clinical and biochemical effects of a 3-week program of diet combined with spa therapy in obese and diabetic patients: a pilot open study

    Science.gov (United States)

    Fioravanti, Antonella; Adamczyk, Przemysław; Pascarelli, Nicola Antonio; Giannitti, Chiara; Urso, Renato; Tołodziecki, Michał; Ponikowska, Irena

    2015-07-01

    Obesity is a major risk factor for arterial hypertension, coronary artery disease, dyslipidemias, and type 2 diabetes. Spa therapy has long been used for treating obesity and its comorbidities. Enlargement of adipose tissue has been linked to a dysregulation of adipokine secretion and adipose tissue inflammation. Adipokines are currently investigated as potential drug targets in these conditions. Our primary aim was to assess the clinical efficacy of a 3-week program of diet combined with spa therapy in obese patients with and without type 2 diabetes. The secondary aim was to examine whether this combined program influences the response of serum levels of leptin, adiponectin, visfatin, and high-sensitivity C-reactive protein. Fifty obese males were enrolled and 21 of these featured a type 2 diabetes. During the 3-week period of the study, the patients were on a 1,000-kcal diet and were involved in mineral bath and total body's mud-pack applications (15 procedures). Patients were assessed at baseline and at the end of the therapy for clinical and biochemical parameters (total cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, glycemia, and adipokines). We showed that a 3-week program of spa therapy in obese patients induced significant decrease of body weight, body mass index, triglycerides, total cholesterol, low-density lipoprotein (LDL) cholesterol, glycemia, and serum levels of leptin and high-sensitivity C-reactive protein. So, a cycle of mud-bath therapy associated with a controlled diet may be a promising treatment for obesity and type 2 diabetes decreasing body weight and many risk factors for atherosclerosis and metabolic syndrome.

  12. Effects of natural factors of Niška Banja spa on indexes of mobility of vertebral column in patients with ankylosing spondylitis

    Directory of Open Access Journals (Sweden)

    Nedović Jovan

    2009-01-01

    Full Text Available Introduction. Ankylosing spondilitis (AS is a disease from a group of seronegative spondyloarthropathies with the prevalence of 0.1% affecting mainly young males, which also gives sociomedical significance to the disease. Among all inflammatory arthropathies, AS is the most suitable for balneotherapy. Thermomineral water of the Niška Banja spa is homeothermic, oligomineral, alkaline, low radioactive radon water and also, in conjunction with mineral peloid, is considered to be optimal for this indication. Objective. Our aim was to investigate the effects of natural factors of the Niška Banja spa as a part of complex treatment on the indexes of mobility of the vertebral column in the patients with AS. Methods. The study enrolled 40 patients with the average age of 48.0±14.82 years and the average duration of disease of 16.9±6.42 years. Patients were treated with hydro- and peloid- otherapy during the average of 17.23±2.71 days. At the beginning and at the end of treatment, a number of indexes of spinal mobility were measured. The statistical significance of differences was calculated using the Student's t-test. Results. All of the measured indexes were better after balneotherapy reaching statistically significant differences in regard to the wall-to-occiput distance (p<0.05, the index of sagittal mobility of the cervical (p<0.05 and lumbar (p<0.005 spine. Conclusion. The application of natural factors of the Niška Banja spa during complex treatment of the patients with AS is accompanied with the objective increase of the spine mobility.

  13. Evaluation of double locus (clfB and spa) sequence typing for studying molecular epidemiology of methicillin-resistant Staphylococcus aureus in Taiwan.

    Science.gov (United States)

    Huang, Chen-Cheng; Ho, Cheng-Mao; Chen, Hui-Chen; Li, Chi-Yuan; Tien, Ni; Fan, Hsiu-Mei; Ge, Mao-Cheng; Lu, Jang-Jih

    2017-10-01

    Pulsed-field gel electrophoresis (PFGE) is the "gold standard" for epidemiological investigation of methicillin-resistant Staphylococcus aureus (MRSA), but several DNA sequence-based methods have been developed in MRSA typing because of the unambiguous results. Ninety-one MRSA isolates were collected from the blood cultures of different patients from July 2008 to December 2008 in central Taiwan. The molecular characteristics of each isolate, including double locus sequence typing (DLST; spa and clfB typing), Staphylococcus cassette chromosome mec (SCCmec), and PFGE were determined for comparison. Five major clfB types (types A-E), 18 spa types, 33 DLST genotypes, five SCCmec types, 17 pulsotypes have been observed. Three major DLST genotypes (A1-t002, C0-t037, and B1-t437) and two major pulsotypes (6 and 8) were identified. Most clfB type A isolates (97.1%) were SCCmec type II and all clfB type C isolates (100%) were SCCmec type III. Most clfB type B isolates (88.9%) were SCCmec type IV (59.3%) and V T (29.6%). All (100%) clfB subtypes A1, A2, and C isolates and 70.4% of clfB type B isolates belonged to healthcare-associated-MRSA. The average congruence was 57.7% between DLST and PFGE, and 96.6% between clfB and SCCmec type. The index of discrimination of SCCmec, clfB, spa, PFGE, and DLST was 0.72, 0.79, 0.80, 0.81, and 0.87, respectively. ClfB type has high congruence with SCCmec type. The DLST method in this study yielded a higher discriminatory power than PFGE in local investigation of molecular epidemiology of MRSA and a promising alternative to PFGE. Copyright © 2015. Published by Elsevier B.V.

  14. A slow-forming isopeptide bond in the structure of the major pilin SpaD from Corynebacterium diphtheriae has implications for pilus assembly

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Hae Joo; Paterson, Neil G. [University of Auckland, Private Bag 92019, Auckland 1142 (New Zealand); Kim, Chae Un [Cornell University, Ithaca, NY 14853 (United States); Middleditch, Martin [University of Auckland, Private Bag 92019, Auckland 1142 (New Zealand); Chang, Chungyu; Ton-That, Hung [University of Texas–Houston Medical School, Houston, TX 77030 (United States); Baker, Edward N., E-mail: ted.baker@auckland.ac.nz [University of Auckland, Private Bag 92019, Auckland 1142 (New Zealand)

    2014-05-01

    Two crystal structures of the major pilin SpaD from C. diphtheriae have been determined at 1.87 and 2.5 Å resolution. The N-terminal domain is found to contain an isopeptide bond that forms slowly over time in the recombinant protein. Given its structural context, this provides insight into the relationship between internal isopeptide-bond formation and pilus assembly. The Gram-positive organism Corynebacterium diphtheriae, the cause of diphtheria in humans, expresses pili on its surface which it uses for adhesion and colonization of its host. These pili are covalent protein polymers composed of three types of pilin subunit that are assembled by specific sortase enzymes. A structural analysis of the major pilin SpaD, which forms the polymeric backbone of one of the three types of pilus expressed by C. diphtheriae, is reported. Mass-spectral and crystallographic analysis shows that SpaD contains three internal Lys–Asn isopeptide bonds. One of these, shown by mass spectrometry to be located in the N-terminal D1 domain of the protein, only forms slowly, implying an energy barrier to bond formation. Two crystal structures, of the full-length three-domain protein at 2.5 Å resolution and of a two-domain (D2-D3) construct at 1.87 Å resolution, show that each of the three Ig-like domains contains a single Lys–Asn isopeptide-bond cross-link, assumed to give mechanical stability as in other such pili. Additional stabilizing features include a disulfide bond in the D3 domain and a calcium-binding loop in D2. The N-terminal D1 domain is more flexible than the others and, by analogy with other major pilins of this type, the slow formation of its isopeptide bond can be attributed to its location adjacent to the lysine used in sortase-mediated polymerization during pilus assembly.

  15. Comparative live-cell imaging analyses of SPA-2, BUD-6 and BNI-1 in Neurospora crassa reveal novel features of the filamentous fungal polarisome.

    Directory of Open Access Journals (Sweden)

    Alexander Lichius

    Full Text Available A key multiprotein complex involved in regulating the actin cytoskeleton and secretory machinery required for polarized growth in fungi, is the polarisome. Recognized core constituents in budding yeast are the proteins Spa2, Pea2, Aip3/Bud6, and the key effector Bni1. Multicellular fungi display a more complex polarized morphogenesis than yeasts, suggesting that the filamentous fungal polarisome might fulfill additional functions. In this study, we compared the subcellular organization and dynamics of the putative polarisome components BUD-6 and BNI-1 with those of the bona fide polarisome marker SPA-2 at various developmental stages of Neurospora crassa. All three proteins exhibited a yeast-like polarisome configuration during polarized germ tube growth, cell fusion, septal pore plugging and tip repolarization. However, the localization patterns of all three proteins showed spatiotemporally distinct characteristics during the establishment of new polar axes, septum formation and cytokinesis, and maintained hyphal tip growth. Most notably, in vegetative hyphal tips BUD-6 accumulated as a subapical cloud excluded from the Spitzenkörper (Spk, whereas BNI-1 and SPA-2 partially colocalized with the Spk and the tip apex. Novel roles during septal plugging and cytokinesis, connected to the reinitiation of tip growth upon physical injury and conidial maturation, were identified for BUD-6 and BNI-1, respectively. Phenotypic analyses of gene deletion mutants revealed additional functions for BUD-6 and BNI-1 in cell fusion regulation, and the maintenance of Spk integrity. Considered together, our findings reveal novel polarisome-independent functions of BUD-6 and BNI-1 in Neurospora, but also suggest that all three proteins cooperate at plugged septal pores, and their complex arrangement within the apical dome of mature hypha might represent a novel aspect of filamentous fungal polarisome architecture.

  16. Wind energy in Mediterranean Basin

    International Nuclear Information System (INIS)

    Gaudiosi, G.

    1991-01-01

    In its examination of wind energy potential in the Mediterranean Basin, this paper provides brief notes on the Basin's geography; indicates power production and demand; describes the area's wind characteristics and wind monitoring activities; illustrates wind velocity distributions; estimates local wind power production potential; reviews the Basin's wind energy marketing situation and each bordering country's wind energy programs; surveys installed wind energy farms; and assesses national research and commercialization efforts

  17. The Results of the Development of Balneal Care Provision and the State of the Czech Spa Industry in Connection with the Changes in Legislation

    Directory of Open Access Journals (Sweden)

    Vavrečková Eva

    2017-06-01

    Full Text Available The paper focuses on the development of balneal care provision and its current state in the Czech spa industry in connection with the changes in legislation. In particular, the period of 2000–2015 is specified, including the survey of positive and negative changes resulting from the changes in legal norms regulating the balneal care provision. Special attention is paid to two turning points in the balneal care provision: the turn of 2012 and 2013 and the turn of 2014 and 2015, which were significantly affected by the changing legislation.

  18. Impact of serum SP-A and SP-D levels on comparison and prognosis of idiopathic pulmonary fibrosis: A systematic review and meta-analysis.

    Science.gov (United States)

    Wang, Kai; Ju, Qing; Cao, Jing; Tang, Wenze; Zhang, Jian

    2017-06-01

    Idiopathic pulmonary fibrosis (IPF) has a poor prognosis in general; however, it is heterogeneous to detect relative biomarkers for predicting the disease progression. Serum biomarkers can be conveniently collected to detect and help to differentially diagnose IPF and predict IPF prognosis. This meta-analysis aimed to evaluate the use of serum surfactant proteins A and D (SP-A and SP-D) for differential diagnosis and prognosis of IPF. Relevant articles were searched in PubMed, Embase, and Chinese National Knowledge Infrastructure databases and reviewed by 2 independent readers. Standard mean difference (SMD) and 95% confidence interval (CI) were calculated to assess the difference in serum levels of SP-A/D among patients with IPF, when compared to patients with non-IPF interstitial lung disease (ILD), pulmonary infection, and healthy control. Hazard ratio (HR) and 95% CI were used to compare the relative risk of mortality. Twenty-one articles (totalling 1289 IPF patients) were included in final meta-analysis. Serum SP-A levels were significantly higher in patients with IPF than in patients with non-IPF ILD (SMD: 1.108 [0.584, 1.632], P infection (SMD: 1.320 [0.999, 1.640], P SMD: 2.802 [1.901, 3.702], P SMD: 0.459 [-0.000, 0.919], P = .050). Serum SP-D levels were significantly higher in patients with IPF than in patients with pulmonary infection (SMD: 1.308 [0.813, 1.803], P SMD: 2.235 [1.739, 2.731], P < .001). Risk of death in patients with IPF and elevated serum SP-A was increased 39% compared to patients with low SP-A groups. Elevated SP-D increased risk by 111% when compared to low SP-D. In acute exacerbation of IPF, serum SP-A/D were higher than those in stable stage. The comparisons and prognosis might be different in Asian and Caucasian patients. Serum SP-A/D detection might be useful for differential diagnosis and prediction of survival in patients with IPF.

  19. Multiple oscillatory modes of the Argentine Basin. Part II. The spectral origin of the basin modes

    NARCIS (Netherlands)

    Weijer, W.; Vevier, F.; Gille, S.T.; Dijkstra, H.A.

    2007-01-01

    In this paper the spectrum of barotropic basin modes of the Argentine Basin is shown to be connected to the classical Rossby basin modes of a flat-bottom (constant depth), rectangular basin. First, the spectrum of basin modes is calculated for the Argentine Basin, by performing a normal-mode

  20. Spa therapy (balneotherapy) relieves mental stress, sleep disorder, and general health problems in sub-healthy people

    Science.gov (United States)

    Yang, Bei; Qin, Qi-zhong; Han, Ling-li; Lin, Jing; Chen, Yu

    2018-02-01

    ( P group ( P 0.05). Spa therapy (balneotherapy) relieves mental stress, sleep disorder, general health, and reduces women's waist circumferences in sub-healthy people.

  1. The detailed analysis of natural radionuclides dissolved in spa waters of the Kłodzko Valley, Sudety Mountains, Poland

    Energy Technology Data Exchange (ETDEWEB)

    Walencik-Łata, A., E-mail: agata.walencik@us.edu.pl [University of Silesia, Institute of Physics, Department of Nuclear Physics and Its Applications, Uniwersytecka 4 St., 40-007 Katowice (Poland); Kozłowska, B.; Dorda, J. [University of Silesia, Institute of Physics, Department of Nuclear Physics and Its Applications, Uniwersytecka 4 St., 40-007 Katowice (Poland); Przylibski, T.A. [Wrocław University of Technology, Faculty of Geoengineering, Mining and Geology, Division of Geology and Mineral Waters, Wybrzeże S. Wyspiańskiego 27, 50-370 Wrocław (Poland)

    2016-11-01

    A survey was conducted to measure natural radioactivity in spa waters from the Kłodzko Valley. The main goal of this study was to determine the activity concentration of uranium, radium and radon isotopes in the investigated groundwaters. Samples were collected several times from 35 water intakes from 5 spas and 2 mineral water bottling plants. The authors examined whether the increased gamma radiation background, as well as the elevated values of radium and uranium content in reservoir rocks, have a significant impact on the natural radioactivity of these waters. The second objective of this research was to provide information about geochemistry of U, Ra, Rn radionuclides and the radiological and chemical risks incurred by ingestion of isotopes with drinking water. On the basis of results obtained, it is feasible to assess the health hazard posed by ingestion of natural radioactivity with drinking waters. Moreover, the data yielded by this research may be helpful in the process of verification of the application of these waters in balneotherapy. In addition, annual effective radiation doses resulting from the isotopes consumption were calculated on the basis of the evaluated activity concentrations. In dose assessment for uranium and radium isotopes, the authors provided values for different human age groups. The obtained uranium content in the investigated waters was compared with the currently valid regulations concerning the quality of drinking water. Based on the activity concentrations data, the activity isotopic ratios {sup 234}U/{sup 238}U, {sup 226}Ra/{sup 238}U, {sup 222}Rn/{sup 238}U, {sup 222}Rn/{sup 226}Ra and the correlations between radionuclides content were then examined. In brief, it may be concluded on the basis of the obtained results that radon solubility is inversely proportional to radium and uranium dissolution in environmental water circulation. The presented study allows conclusions to be drawn on the radionuclide circulation among

  2. Beneficial effects of spa treatment on functional status and quality of life of patients with rheumatoid arthritis

    Directory of Open Access Journals (Sweden)

    Mustur Dušan

    2008-01-01

    Full Text Available INTRODUCTION Rheumatoid arthritis (RA is a chronic constantly deteriorating disease of unpredictable clinical course, with exacerbations, remissions and damaged joints. It leads to the loss of self-sufficiency, independence in performing many daily activities, decrease of working ability and invalidity. Beside physical factors, which are regarded as most responsible for the poorer quality of life of RA patients, psychological changes are also significant, such as the feeling of helplessness, hopelessness and depression. The goal of the treatment of patients with RA is to decrease illness symptoms, slow down the development of illness progression, improvement of physical functioning and provision of expert help to the RA patients to adapt to life. OBJECTIVE The aim of the study was to assess the influence of spa therapy on the functional condition and life quality of RA patients. METHODS The study involved 69 patients with RA (51 female and 18 male, on average aged 55.2±11.4 years, with illness duration 12.5±7.5 years, and were a part of a cohort from Norway, suffering of inflammatory rheumatism. All the patients came for four-week rehabilitation at the Institute for Physical Medicine, Rehabilitation and Rheumatology "Dr. Simo Milošević" in Igalo, Montenegro. The RA patients underwent treatment with mud compresses, mud, mineral and pearl baths, as well as with underwater shower massage (balneotherapy kinesitherapy and certain forms of electrotherapy with analgesic effects. The evaluation was done on admission and after completed physical therapy when we assessed RA patients' functional condition and quality of life. The functional condition was determined using the Modified Health Assessment Questionnaire (MHAQ, and the quality of life using the Medical Outcomes Study Short Form 36-item Questionnaire (SF-36, which encompassed eight life domains. RESULTS After completion of 28-dayspa therapy, RA patients showed a significant improvement in

  3. Geophysical Investigation of the Raton Basin.

    Science.gov (United States)

    1982-05-01

    65 miles wide, the Raton Basin is divided by the Cimarron Arch into the northern Raton Basin and the Las Vegas Basin on the south. The deepest...to the east, the Cimarron Arch on the north, and was linked by a low saddle to the Tucumcari Basin to the south. The Colorado and Rowe-Mora Basins...sedimentary rock thinning near the Apishipa, Cimarron , and Sierra Grande Arches; 2) presence of volcanic rock in the southern portion of the Basin; 3

  4. Light and the E3 ubiquitin ligase COP1/SPA control the protein stability of the MYB transcription factors PAP1 and PAP2 involved in anthocyanin accumulation in Arabidopsis.

    Science.gov (United States)

    Maier, Alexander; Schrader, Andrea; Kokkelink, Leonie; Falke, Christian; Welter, Bastian; Iniesto, Elisa; Rubio, Vicente; Uhrig, Joachim F; Hülskamp, Martin; Hoecker, Ute

    2013-05-01

    Anthocyanins are natural pigments that accumulate only in light-grown and not in dark-grown Arabidopsis plants. Repression of anthocyanin accumulation in darkness requires the CONSTITUTIVELY PHOTOMORPHOGENIC1/SUPPRESSOR OF PHYA-105 (COP1/SPA) ubiquitin ligase, as cop1 and spa mutants produce anthocyanins also in the dark. Here, we show that COP1 and SPA proteins interact with the myeloblastosis (MYB) transcription factors PRODUCTION OF ANTHOCYANIN PIGMENT1 (PAP)1 and PAP2, two members of a small protein family that is required for anthocyanin accumulation and for the expression of structural genes in the anthocyanin biosynthesis pathway. The increased anthocyanin levels in cop1 mutants requires the PAP1 gene family, indicating that COP1 functions upstream of the PAP1 gene family. PAP1 and PAP2 proteins are degraded in the dark and this degradation is dependent on the proteasome and on COP1. Hence, the light requirement for anthocyanin biosynthesis results, at least in part, from the light-mediated stabilization of PAP1 and PAP2. Consistent with this conclusion, moderate overexpression of PAP1 leads to an increase in anthocyanin levels only in the light and not in darkness. Here we show that SPA genes are also required for reducing PAP1 and PAP2 transcript levels in dark-grown seedlings. Taken together, these results indicate that the COP1/SPA complex affects PAP1 and PAP2 both transcriptionally and post-translationally. Thus, our findings have identified mechanisms via which the COP1/SPA complex controls anthocyanin levels in Arabidopsis that may be useful for applications in biotechnology directed towards increasing anthocyanin content in plants. © 2013 The Authors The Plant Journal © 2013 John Wiley & Sons Ltd.

  5. Feasibility study for the installation of HVAC for a spa by means of energy recovery from thermal water. Pt. 2: Energy analysis

    Energy Technology Data Exchange (ETDEWEB)

    Tabares, J.L. Miguez [Universidad de Vigo, Dept. de Ingenieria Mecanica, Vigo (Spain); Alvarez, M. Gandara [ISOLUX Espana, Vigo (Spain); Gonzalez, L.M. Lopez [Universidad de La Rioja, Dept. de Ingenieria Mecanica, Logrono (Spain); Viar, P. Fernandez [Universidad de Oviedo, Dept. de Energia, Oviedo (Spain)

    2001-05-01

    The use of a low temperature geothermal spring together with the heat energy still contained in waste water from the different therapy systems installed in a spa (shower, jets, bathrooms, jacuzzis, pools, ventilation processes) can significantly reduce the operating and maintenance costs of the installation. This covers part of the air conditioning needs of the building and of the heating of thermal water to the appropriate temperature for therapeutic use. In the first part of the study, an analysis of the spring's situation was made, calculating the thermal water needs and presenting the consumption according to the operation schedule on different types of day. In this way, the contribution the spring was capable of giving was compared and the evolution of the thermal water in the tanks was studied. In the second part, the climatic conditions that the spa should meet are studied, along with the loads that it should support, the energy reclaimed from the different heat focuses and the repercussions on the final solution. (Author)

  6. Feasibility study for the installation of HVAC for a spa by means of energy recovery from thermal water. Pt. 1: Analysis of conditions

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez, L.M. Lopez [Universidad de La Rioja, Dept. de Ingenieria Mecanica, Logrono (Spain); Tabares, J.L. Miguez; Viar, P. Fernandez [Universidad de Oviedo, E.T.S. Ingegieros de Minas, Oviedo (Spain); Alvarez, M. Gandara [ISOLUX Galicia, Vigo (Spain)

    2001-05-01

    The use of a low temperature geothermal spring together with the heat energy still contained in waste water from the different therapy systems installed in a spa (shower, jets, bathrooms, Jacuzzis, pools, ventilation processes) can significantly reduce the operating and maintenance costs of the installation, covering part of the air conditioning needs of the building and the heating of thermal water to the appropriate temperature for therapeutic use. The object of the present work is to study the possible energy use of two sources of thermal hot water (spring and waste water) by restructuring of the existing spa so that it is more efficient from both a technical and economic point of view. In this first part, hot water needs are calculated and consumption presented according to the operation schedule on different types of day. Comparison is then made with the contribution that the spring is capable of making and the evolution of the thermal water in the tanks is studied. In a second work, energy and economic analyses will be presented. (Author)

  7. Waste heat utilization in the thermal spa of Lavey-les-Bains; Etude de la valorisation des rejets thermiques des Bains de Lavey

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-07-01

    This final report for the Swiss Federal Office of Energy looks at the possibilities for improved waste water utilization in the Lavey-les-Bains thermal spa, Switzerland. According to the regulations in force, the temperature of the waste water rejected into the Rhone river shall not exceed 30 {sup o}C, what is currently not the case. Also the operational cost shall be reduced and the waste water quality improved. The installations are presented. From the two geothermal wells, mineral water comes out at an average flow rate of 940 l/min and a temperature of 63 {sup o}C. Actual waste water data are reported. The measured thermal water consumption data, including seasonal variations, are analysed by computerized simulation and measures to reduce the consumed volume by the optimization of internal procedures are evaluated. Measures to reduce the quantity of the rejected free chlorine are discussed. Several possible adaptations of the existing space heating, domestic water heating and pools' heating are evaluated, including cost. In addition, extensions of the thermal spa center to recreational activities are discussed, as the construction of a tropical greenhouse is.

  8. Molecular diversity and high virulence of Legionella pneumophila strains isolated from biofilms developed within a warm spring of a thermal spa

    Directory of Open Access Journals (Sweden)

    Chaabna Zineddine

    2013-01-01

    Full Text Available Abstract Background Several cases of legionellosis have been diagnosed in the same French thermal spa in 1986, 1994 and 1997. L. pneumophila serogroup 1 (Lp1 strains have been isolated from several patients, but the source of contamination was not identified despite the presence of different Lp1 in water samples of the three natural springs feeding the spa at this period. Results Our strategy was to investigate L. pneumophila (Lp strains from natural biofilms developed in a sulphur-rich warm spring of this contaminated site. Biofilm analysis revealed the presence of three Lp serogroups (Lp1, Lp10 and Lp12. Surprisingly, Lp10 and Lp12 were not reported in the previous described studies from water samples. Besides, the new seven Lp1 we isolated exhibit a high molecular diversity and have been differentiated in five classes according to their DNA genome patterns obtained by PFGE and mip sequences. It must be noted that these DNA patterns are original and unknown in databases. Interestingly, the 27 Lp environmental strains we isolated display a higher cytotoxicity and virulence towards the amoeba Acanthamoeba castellanii than those of known Lp1 epidemic strains. Conclusion The characteristics of Legionella pneumophila Lp1 strains isolated from the warm spring are in agreement with their presence in biofilms and their probable long-term persistence in this ecosystem.

  9. Impact of radon and combinatory radon/carbon dioxide spa on pain and hypertension: Results from the explorative RAD-ON01 study.

    Science.gov (United States)

    Rühle, Paul F; Klein, Gerhart; Rung, Tatiana; Tiep Phan, Hong; Fournier, Claudia; Fietkau, Rainer; Gaipl, Udo S; Frey, Benjamin

    2018-03-02

    Therapies with low doses of radon have beneficial effects on patients suffering from chronic painful degenerative and inflammatory diseases. We already showed that this is accompanied by systemic immune modulations. We here focus on pain-reducing effects of very low doses of radon by adding carbon dioxide water and its impact on heart rate variability (HRV), blood pressure and free radicals. 97 of 103 patients receiving radon spa (1.200 Bq/l at 34 °C or 600 Bq/l, 1 g/l CO 2 at 34 °C) were monitored before and at three different time points after therapy. Individual pain perception was analyzed and the capability to process radicals. At each time point, the hypertensive patients (n = 46) were examined over 24 h for blood pressure and HRV. Long-term pain reduction was observed in the majority of patients. A modulation of superoxide dismutase was identified, presumably representing a priming effect for lowering radiation stress. Further, lowering of blood pressure, especially in those patients who additionally received carbon dioxide, was seen. Radon did in particular impact on HRV implying lasting relaxation effects. Radon/carbon dioxide spa efficiently reduces pain. In particular, patients simultaneously suffering from painful and cardiovascular diseases should be treated by combination of radon and CO 2 .

  10. SpaGrOW—A Derivative-Free Optimization Scheme for Intermolecular Force Field Parameters Based on Sparse Grid Methods

    Directory of Open Access Journals (Sweden)

    Dirk Reith

    2013-09-01

    Full Text Available Molecular modeling is an important subdomain in the field of computational modeling, regarding both scientific and industrial applications. This is because computer simulations on a molecular level are a virtuous instrument to study the impact of microscopic on macroscopic phenomena. Accurate molecular models are indispensable for such simulations in order to predict physical target observables, like density, pressure, diffusion coefficients or energetic properties, quantitatively over a wide range of temperatures. Thereby, molecular interactions are described mathematically by force fields. The mathematical description includes parameters for both intramolecular and intermolecular interactions. While intramolecular force field parameters can be determined by quantum mechanics, the parameterization of the intermolecular part is often tedious. Recently, an empirical procedure, based on the minimization of a loss function between simulated and experimental physical properties, was published by the authors. Thereby, efficient gradient-based numerical optimization algorithms were used. However, empirical force field optimization is inhibited by the two following central issues appearing in molecular simulations: firstly, they are extremely time-consuming, even on modern and high-performance computer clusters, and secondly, simulation data is affected by statistical noise. The latter provokes the fact that an accurate computation of gradients or Hessians is nearly impossible close to a local or global minimum, mainly because the loss function is flat. Therefore, the question arises of whether to apply a derivative-free method approximating the loss function by an appropriate model function. In this paper, a new Sparse Grid-based Optimization Workflow (SpaGrOW is presented, which accomplishes this task robustly and, at the same time, keeps the number of time-consuming simulations relatively small. This is achieved by an efficient sampling procedure

  11. K-Basins design guidelines

    International Nuclear Information System (INIS)

    Roe, N.R.; Mills, W.C.

    1995-06-01

    The purpose of the design guidelines is to enable SNF and K Basin personnel to complete fuel and sludge removal, and basin water mitigation by providing engineering guidance for equipment design for the fuel basin, facility modifications (upgrades), remote tools, and new processes. It is not intended to be a purchase order reference for vendors. The document identifies materials, methods, and components that work at K Basins; it also Provides design input and a technical review process to facilitate project interfaces with operations in K Basins. This document is intended to compliment other engineering documentation used at K Basins and throughout the Spent Nuclear Fuel Project. Significant provisions, which are incorporated, include portions of the following: General Design Criteria (DOE 1989), Standard Engineering Practices (WHC-CM-6-1), Engineering Practices Guidelines (WHC 1994b), Hanford Plant Standards (DOE-RL 1989), Safety Analysis Manual (WHC-CM-4-46), and Radiological Design Guide (WHC 1994f). Documents (requirements) essential to the engineering design projects at K Basins are referenced in the guidelines

  12. Geologic Basin Boundaries (Basins_GHGRP) GIS Layer

    Data.gov (United States)

    U.S. Environmental Protection Agency — This is a coverage shapefile of geologic basin boundaries which are used by EPA's Greenhouse Gas Reporting Program. For onshore production, the "facility" includes...

  13. Marketing San Juan Basin gas

    International Nuclear Information System (INIS)

    Posner, D.M.

    1988-01-01

    Marketing natural gas produced in the San Juan Basin of New Mexico and Colorado principally involves four gas pipeline companies with significant facilities in the basin. The system capacity, transportation rates, regulatory status, and market access of each of these companies is evaluated. Because of excess gas supplies available to these pipeline companies, producers can expect improved take levels and prices by selling gas directly to end users and utilities as opposed to selling gas to the pipelines for system supply. The complexities of transporting gas today suggest that the services of an independent gas marketing company may be beneficial to smaller producers with gas supplies in the San Juan Basin

  14. Great Basin Experimental Range: Annotated bibliography

    Science.gov (United States)

    E. Durant McArthur; Bryce A. Richardson; Stanley G. Kitchen

    2013-01-01

    This annotated bibliography documents the research that has been conducted on the Great Basin Experimental Range (GBER, also known as the Utah Experiment Station, Great Basin Station, the Great Basin Branch Experiment Station, Great Basin Experimental Center, and other similar name variants) over the 102 years of its existence. Entries were drawn from the original...

  15. River basin management and community : the Great Ouse Basin, 1850–present

    NARCIS (Netherlands)

    Mostert, E.

    2017-01-01

    River basins are difficult units to manage. Society is generally not organized on the basis of river basins, yet river basins are important units for society and vice versa. This paper discusses the development and effectiveness of river basin management, using the Great Ouse Basin in the east of

  16. How does spa treatment affect cardiovascular function and vascular endothelium in patients with generalized osteoarthritis? A pilot study through plasma asymmetric di-methyl arginine (ADMA) and L-arginine/ADMA ratio

    Science.gov (United States)

    Karaarslan, Fatih; Ozkuk, Kagan; Seringec Karabulut, Serap; Bekpinar, Seldag; Karagulle, Mufit Zeki; Erdogan, Nergis

    2017-12-01

    The study aims to investigate the effect of spa treatment on vascular endothelium and clinical symptoms of generalized osteoarthritis. Forty generalized osteoarthritis (GOA) patients referred to a government spa hospital, and 40 GOA patients followed on university hospital locomotor system disease ambulatory clinics were included as study and control groups, respectively. Study group received spa treatment including thermal water baths, physical therapy modalities, and exercises. Control group was followed with home exercises for 15 days. Plasma ADMA, L-arginine, L-arginine/ADMA ratio, routine blood analyses, 6-min walking test, including fingertip O2 saturation, systolic/diastolic blood pressure, and pulse rate, were measured at the beginning and at the end of treatment. Groups were evaluated with VAS pain, patient, and physician global assessment; HAQ; and WOMAC at the beginning, at the end, and after 1 month of treatment. In study group, L-arginine and L-arginine/ADMA ratio showed statistically significant increase after treatment. Plasma ADMA levels did not change. There is no significant difference in intergroup comparison. Study group displayed statistically significant improvements in all clinical parameters. The study showed that spa treatment does not cause any harm to the vascular endothelium through ADMA. Significant increase in plasma L-arginine and L-arginine/ADMA ratio suggests that balneotherapy may play a preventive role on cardiovascular diseases. Balneotherapy provides meaningful improvements on clinical parameters of GOA.

  17. Teaching Grammar and Testing Grammar in the English Primary School: The Impact on Teachers and Their Teaching of the Grammar Element of the Statutory Test in Spelling, Punctuation and Grammar (SPaG)

    Science.gov (United States)

    Safford, Kimberly

    2016-01-01

    The research examined the impact on teachers of the grammar element of a new statutory test in Spelling, Punctuation and Grammar (SPaG) in primary schools in England. The research aimed to evaluate the nature and the extent of changes to the teaching of grammar and to wider literacy teaching since the introduction of the test in 2013. The research…

  18. Allegheny County Basin Outlines Map

    Data.gov (United States)

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — This basins dataset was created to initiate regional watershed approaches with respect to sewer rehabilitation. If viewing this description on the Western...

  19. Sustaining Exploration in Mature Basins

    International Nuclear Information System (INIS)

    Bayo, A.

    2002-01-01

    Exploration is a business like any other business driven by opportunity, resources and expectation of profit. Therefore, exploration will thrive anywhere the opportunities are significant, the resources are available and the outlook for profit (or value creation) is good. To sustain exploration activities anywhere, irrespective of the environment, there must be good understanding of the drivers of these key investment criteria. This paper will examine these investment criteria as they relate to exploration business and address the peculiarity of exploration in mature basin. Mature basins are unique environment that lends themselves a mix of fears, paradigms and realities, particularly with respect to the perception of value. To sustain exploration activities in a mature basin, we need to understand these perceptions relative to the true drivers of profitability. Exploration in the mature basins can be as profitable as exploration in emerging basins if the dynamics of value definition-strategic and fiscal values are understood by operators, regulators and co ventures alike. Some suggestions are made in this presentation on what needs to be done in addressing these dynamic investment parameters and sustaining exploration activities in mature basins

  20. Noise level arrangement in determined zones of homogenous development of green areas on the example of the spa park in Inowrocław

    Science.gov (United States)

    Sztubecka, Małgorzata; Skiba, Marta

    2016-11-01

    Noise measurements are usually carried out in developed areas as well as in the surroundings of traffic routes providing basis for actions in order to limit its influence on the neighboring areas. Noise measurements in park areas are rare due to belief that these areas are silent zones. Such attitude cannot be justified. This article aims to the assessment of noise appearing in determined subzones of the spa park in Inowrocław. From the research carried out it can be noticed that traffic noise does not have any important meaning for the acoustic climate of the park. It is the people who stay there who generate more noise. Comparative analysis proves the appearance and penetration of noise from the zones with greater level of noise to the ones with lower amount.

  1. The system of green surfaces in spas with special reference to the case studies: Vrnjačka, Kanjiža and Pribojska SPA

    Directory of Open Access Journals (Sweden)

    Crnčević Tijana

    2008-01-01

    Full Text Available Taking into consideration the significance of the vegetation in urban areas the paper analyses current and attached regulations in Serbia relevant for planning and preserving of the system of green surfaces, with special reference to the spas. Referring to the results, it is pointed out the limitations of the current legal framework. Also, the existing planning documents for Vrnjačka, Pribojska and Kanjiža spa are analyzed. Referring to the obtained results, the recommendations are formulized with special reference to the system of green surfaces in spas. They stand for harmonization and improvement of the existing law regulations for the system of green surfaces and also for providing corresponding legal and other mechanisms, where financial support for the plan realization and efficient management is included. .

  2. Learning with companies (LeWiCo through the use of Facebook in the context of vocational hospitality education and digital spa marketing

    Directory of Open Access Journals (Sweden)

    Annica Isacsson

    2016-01-01

    The article adopts a case study approach to describe in detail how Facebook was used to foster self-directed and co-constructive learning in a social environment. The findings presented in the article are based on the postings of participating students in Facebook, and on teachers and project team reflections. Overall, the project was a success and led to the construction of a useful, current and engaging knowledge base in the context of spa marketing. Moreover, the students appreciated the informal learning environment, and the teachers learned how to enhance learning without suffocating the learning process with too many guidelines or information. The students learned how to collaborate independently, and in pairs, and to take responsibility of their own learning.

  3. [The spa and resort-based health-promoting treatment of the vehicle drivers suffering from duodenal ulcer disease: the effectiveness and safety].

    Science.gov (United States)

    El'garov, A A; Kalmykova, M A; El'garova, R M; Betuganova, L V; El'garov, M A

    2015-01-01

    To evaluate the effectiveness and the safety of the spa and resort-based health-promoting treatment of the vehicle drivers (VD) presenting with duodenal ulcer disease. A total of 67 men suffering from duodenal ulcer disease (DUD) were allocated to two groups. The patients of group 1 (n = 35) were given the courses of balneotherapy that included bromine-iodine mineral baths with a temperature of 36-37 degrees C (8-9 procedures 10-15 min long each every second day) in combination with 8-9 peloid applications to the epigastric region (temperature 38-40 degrees C for 10-15 min every second day). The patients of group 2 (n = 32) were given the similar courses of therapy that included nitric thermal mineral baths with a temperature of 36-37 degrees C (8-9 procedures 10-15 min long each every second day) in combination with 8-9 peloid applications to the epigastric region (38-40 degrees C for 10-15 min every second day). The effectiveness and safety of these balenotherapeutic procedures for the treatment of duodenal ulcer disease in the subjects of the study and control (n = 47) groups were evaluated based on the results of the routine clinical and endoscopic examination, psychological and psychophysiological tests, and the comparative analysis of medical aid appeal-ability and disability cases during twelve months. Dynamics of clinical and instrumental characteristics (subjective, objective, clinical, endoscopic, psychophysiological) suggested the improvement of the health status in 88.6% and 84.4% of the drivers with duodenum ulcer in the two study groups respectively. Some of the patients comprising group 1 showed significant negative dynamics of the operative reaction system while the patients of group 2 demonstrated the marked improvement of the professionally significant functions and properties (PSF&P). The comparative analysis of medical aid appealability, disability cases, frequency of relapses and complications revealed the favorable clinical course of duodenal

  4. Consumindo luxo e “relax” no espaço urbano da metrópole: análise do Copacabana Palace Spa

    Directory of Open Access Journals (Sweden)

    Maria Helena Carmo Santos

    2013-11-01

    Full Text Available Um dos locais mais conhecidos do Brasil, o bairro de Copacabana e a praia de mesmo nome dividem o imaginário da região com o Copacabana Palace, um dos hotéis mais famosos no mundo e símbolo de status, tradição e exclusividade. Parte integrante das gama de serviços do hotel, o Copacabana Palace Spa é um “oásis” urbano, um espaço de bem-estar e lazer no meio da metrópole, e um local onde as experiências mesclam atributos do hotel, da praia, do Rio de Janeiro e do Brasil.

  5. Consumindo luxo e “relax” no espaço urbano da metrópole: análise do Copacabana Palace Spa

    OpenAIRE

    Maria Helena Carmo Santos; Alessandra Figueredo Porto

    2013-01-01

    Um dos locais mais conhecidos do Brasil, o bairro de Copacabana e a praia de mesmo nome dividem o imaginário da região com o Copacabana Palace, um dos hotéis mais famosos no mundo e símbolo de status, tradição e exclusividade. Parte integrante das gama de serviços do hotel, o Copacabana Palace Spa é um “oásis” urbano, um espaço de bem-estar e lazer no meio da metrópole, e um local onde as experiências mesclam atributos do hotel, da praia, do Rio de Janeiro e do Brasil.

  6. Transmission of endemic ST22-MRSA-IV on four acute hospital wards investigated using a combination of spa, dru and pulsed-field gel electrophoresis typing.

    LENUS (Irish Health Repository)

    Creamer, E

    2012-11-01

    The transmission of meticillin-resistant Staphylococcus aureus (MRSA) between individual patients is difficult to track in institutions where MRSA is endemic. We investigated the transmission of MRSA where ST22-MRSA-IV is endemic on four wards using demographic data, patient and environmental screening, and molecular typing of isolates. A total of 939 patients were screened, 636 within 72 h of admission (on admission) and 303 >72 h after admission, and 1,252 environmental samples were obtained. Isolates were typed by spa, dru and pulsed-field gel electrophoresis (PFGE) typing. A composite dendrogram generated from the three sets of typing data was used to divide isolates into \\'dendrogram groups\\' (DGs). Ten percent of patients (92\\/939) were MRSA-positive; 7 % (44\\/636) on admission and 16 % (48\\/303) >72 h after admission (p = 0.0007). MRSA was recovered from 5 % of environmental specimens (65\\/1,252). Most isolates from patients (97 %, 85\\/88) and the environment (97 %, 63\\/65) exhibited the ST22-MRSA-IV genotype. Four DGs (DG1, DG4, DG16 and DG17) accounted for 58 % of ST22-MRSA-IV isolates from patients. Epidemiological evidence suggested cross-transmission among 44\\/92 patients (48 %) but molecular typing confirmed probable cross-transmission in only 11 instances (13 %, 11\\/88), with the majority of cross-transmission (64 %; 7\\/11) occurring on one ward. In the setting of highly clonal endemic MRSA, the combination of local epidemiology, PFGE, spa and dru typing provided valuable insights into MRSA transmission.

  7. [The modular strategy for the informational support of medical activities based at the spa and health resort facilities under conditions of infrastructure deficit].

    Science.gov (United States)

    Yezhov, V V; Goldberg, D L; Grigorev, P E; Mizin, V I; Olenchuk, A V; Vasilieva, I V

    2017-12-05

    The Crimean peninsula, by virtue of its unique geographical conditions, has a variety of natural resources providing a basis for the maintenance of the health resort activities in the region. However, most local health centers suffer from the chronic and difficultly avoidable in the short term problems with logistical support, including the shortage of computers and the lack of modern network infrastructure. This circumstance limits the deployment capabilities of high-grade medical information systems for the automation of all components of the activity of health resorts and the significant improvement of the performance of other aspects of their work, such as efficient patient routing, workflow optimization, limiting the opportunities for the realization of certain corruption schemes by the staff. We have studied the routing of patients and the associated document flow in a number of Crimean spa and health resort facilities (sanatoriums). As a result, the basic work places at which information contained in the documents is undergoing changes were identified. Based on these data, the basic (modular) concept of the development of medical information system was formulated. According to the principle of modularity, the structure of the information system has been modified and optimized. The stages of implementation of this approach at various levels of logistic facilities were described, defined and justified. The key feature of the proposed system consists in that even the minimal equipment of computing infrastructure units (starting from a single workplace, such as a «medical receptionist») may be sufficient to achieve the significant degree of automation in the workflow, provide monitoring and analysis of the medical records of the spa and health resort facilities. By gradually increasing the number of related automated workplaces and modules, it is possible to expand the capabilities of the system up to the full automation of a given health resort facility.

  8. Eco-SpaCE: An object-oriented, spatially explicit model to assess the risk of multiple environmental stressors on terrestrial vertebrate populations

    International Nuclear Information System (INIS)

    Loos, Mark; Ragas, Ad M.J.; Plasmeijer, Rinus; Schipper, Aafke M.; Hendriks, A. Jan

    2010-01-01

    Wildlife organisms are exposed to a combination of chemical, biological and physical stressors. Information about the relative impact of each stressor can support management decisions, e.g., by the allocation of resources to counteract those stressors that cause most harm. The present paper introduces Eco-SpaCE; a novel receptor-oriented cumulative exposure model for wildlife species that includes relevant ecological processes such as spatial habitat variation, food web relations, predation, and life history. A case study is presented in which the predicted mortality due to cadmium contamination is compared with the predicted mortality due to flooding, starvation, and predation for three small mammal species (Wood mouse, Common vole, and European mole) and a predator (Little owl) living in a lowland floodplain along the river Rhine in The Netherlands. Results indicated that cadmium is the principal stressor for European mole and Little owl populations. Wood mouse and Common vole population densities were mainly influenced by flooding and food availability. Their estimated population sizes were consistent with numbers reported in literature. Predictions for cadmium accumulation and flooding stress were in agreement with field data. The large uncertainty around cadmium toxicity for wildlife leads to the conclusion that more species-specific ecotoxicological data is required for more realistic risk assessments. The predictions for starvation were subject to the limited quantitative information on biomass obtainable as food for vertebrates. It is concluded that the modelling approach employed in Eco-SpaCE, combining ecology with ecotoxicology, provides a viable option to explore the relative contribution of contamination to the overall stress in an ecosystem. This can help environmental managers to prioritize management options, and to reduce local risks.

  9. Rationale and design of the Staying Positive with Arthritis (SPA) Study: A randomized controlled trial testing the impact of a positive psychology intervention on racial disparities in pain.

    Science.gov (United States)

    Hausmann, Leslie R M; Ibrahim, Said A; Kwoh, C Kent; Youk, Ada; Obrosky, D Scott; Weiner, Debra K; Vina, Ernest; Gallagher, Rollin M; Mauro, Genna T; Parks, Acacia

    2018-01-01

    Knee osteoarthritis is a painful, disabling condition that disproportionately affects African Americans. Existing arthritis treatments yield small to moderate improvements in pain and have not been effective at reducing racial disparities in the management of pain. The biopsychosocial model of pain and evidence from the positive psychology literature suggest that increasing positive psychological skills (e.g., gratitude, kindness) could improve pain and functioning and reduce disparities in osteoarthritis pain management. Activities to cultivate positive psychological skills have been developed and validated; however, they have not been tested in patients with osteoarthritis, their effects on racial differences in health outcomes have not been examined, and evidence of their effects on health outcomes in patients with other chronic illnesses is of limited quality. In this article we describe the rationale and design of Staying Positive with Arthritis (SPA) study, a randomized controlled trial in which 180 African American and 180 White primary care patients with chronic pain from knee osteoarthritis will be randomized to a 6-week program of either positive skill-building activities or neutral control activities. The primary outcomes will be self-reported pain and functioning as measured by the WOMAC Osteoarthritis Index. We will assess these primary outcomes and potential, exploratory psychosocial mediating variables at an in-person baseline visit and by telephone at 1, 3, and 6months following completion of the assigned program. If effective, the SPA program would be a novel, theoretically-informed psychosocial intervention to improve quality and equity of care in the management of chronic pain from osteoarthritis. Published by Elsevier Inc.

  10. Eco-SpaCE: an object-oriented, spatially explicit model to assess the risk of multiple environmental stressors on terrestrial vertebrate populations.

    Science.gov (United States)

    Loos, Mark; Ragas, Ad M J; Plasmeijer, Rinus; Schipper, Aafke M; Hendriks, A Jan

    2010-08-15

    Wildlife organisms are exposed to a combination of chemical, biological and physical stressors. Information about the relative impact of each stressor can support management decisions, e.g., by the allocation of resources to counteract those stressors that cause most harm. The present paper introduces Eco-SpaCE; a novel receptor-oriented cumulative exposure model for wildlife species that includes relevant ecological processes such as spatial habitat variation, food web relations, predation, and life history. A case study is presented in which the predicted mortality due to cadmium contamination is compared with the predicted mortality due to flooding, starvation, and predation for three small mammal species (Wood mouse, Common vole, and European mole) and a predator (Little owl) living in a lowland floodplain along the river Rhine in The Netherlands. Results indicated that cadmium is the principal stressor for European mole and Little owl populations. Wood mouse and Common vole population densities were mainly influenced by flooding and food availability. Their estimated population sizes were consistent with numbers reported in literature. Predictions for cadmium accumulation and flooding stress were in agreement with field data. The large uncertainty around cadmium toxicity for wildlife leads to the conclusion that more species-specific ecotoxicological data is required for more realistic risk assessments. The predictions for starvation were subject to the limited quantitative information on biomass obtainable as food for vertebrates. It is concluded that the modelling approach employed in Eco-SpaCE, combining ecology with ecotoxicology, provides a viable option to explore the relative contribution of contamination to the overall stress in an ecosystem. This can help environmental managers to prioritize management options, and to reduce local risks. Copyright 2009 Elsevier B.V. All rights reserved.

  11. [The external application of "Plastunskaya" fluoride-containing mineral water in the course of the combined spa and health resort-based treatment of deforming osteoarthrosis].

    Science.gov (United States)

    Mel'nichuk, L P; Khodasevich, L S

    2015-01-01

    Mineral waters containing fluorine (fluorinated waters) at a concentration in excess of 1 mg per liter are extensively used in the newly developing spa and health resort areas of the Russian Federation. They have been found in Siberia, Trans-Baikal regions, and the Krasnodar Territory (together with the Greater Sochi). These waters are mainly used for drinking as a component of the balneo- therapeutic treatment. In this context, the study of the therapeutic effects of low-mineralized hydrocarbonate-sodium waters containing fluorine in high concentrations is of paramount importance for the substantiation and facilitation of their external application in the framework of the programs of combined spa and health resort-based treatment of various diseases. We have investigated the possibility of the external application of "Plastunskaya" mineral water characterized above all by the high content of fluorine for the external treatment of osteoarthritis in 187 patients at the age varying from 37 to 63 years in the combination with the sparing regimen of physical activity, therapeutic physical exercises, klimatotherapy of moderate intensity, and a balanced diet. The patients were prescribed to take general "Plastunskaya" mineral water baths with the fluoride concentration of 7.4 mg/l at a temperature of 36 C from 7 to 15 minutes in duration for 2 consecutive days with a break on every third day (the total course consisted of 14-16 baths). It was shown that the combined treatment with the use of fluorine-containing mineral water resulted in the significant improvement of the clinical and biochemical parameters characterizing the health status of the patients suffering from deforming osteoarthrosis.

  12. [The spa and health resort-based treatment of metabolic syndrome with the application of the therapeutic courses of different duration: the evaluation according long-term results].

    Science.gov (United States)

    Chalaya, E N; Botvineva, L A; Tsallagova, L V; Ahkubekova, N K; Efimenko, N V; Kaysinova, A S; Amiyants, V Yu; Vasin, V A

    The objective of the present study was to estimate the effectiveness of the new therapeutic modalities for the spa and health resort-based treatment of metabolic syndrome based on the results of the long-term follow-up observations. A total of 100 patients presenting with metabolic syndrome were recruited for the participation in the study. All of them underwent a shortened course of mineral water intake in the combination with the use of the herbal medicinal products. The results of the study give evidence of the more favorable changes in the clinical and instrumental characteristics of the patients with metabolic syndrome treated with the use of the proposed approach in comparison the patients treated by the conventional methods. Moreover, the beneficial effects of the proposed approach persisted during a longer period. The basal treatment given to our patients was supplemented by dietary therapy, therapeutic physical exercise, narzan baths, intake of mineral water having a temperature of 35-37 °С in conjunction with sulphate mineral water (narzan) cooled to 13-15 °С, and a phytococktail. The results of the long-term observations confirmed the enhanced effectiveness of the spa and health resort-based treatment of metabolic syndrome including the therapeutic courses with the intake of cooled narzan mineral water in the combination with phytococktails. This therapeutic modality increased the duration of the favorable changes of various parameters that characterize metabolic syndrome. Specifically, they persisted during 5-6 months after the application of the standard methods, were still apparent within 6-7 months after the two-week course of the treatment with cold narzan and phytococktails, and during 8-9 months when the duration of the treatment course was extended up to 3 weeks.

  13. SCCmec type IX element in Methicillin resistant Staphylococcus aureus spa-type t337 (CC9 isolated from pigs and pork in Thailand

    Directory of Open Access Journals (Sweden)

    Martin eVestergaard

    2012-03-01

    Full Text Available Methicillin resistant Staphylococcus aureus (MRSA have emerged among livestock in several countries. In this study, we describe the results of a screening performed in pigs and raw pork samples in Thailand. Ten pork samples and 15 nasal swabs from pigs were collected from two markets and one pig farm in the Samuth Songkhram province in Thailand. MRSA were isolated using selective isolation procedures and confirmed by mecA PCR. The MRSA were characterized by antimicrobial susceptibility testing, PFGE, spa typing, SCCmec typing, and MLST. Resistance and virulence markers were screened using a microarray. Five of the pork samples and six pig nasal swabs were positive for MRSA. All 11 isolates belonged to spa type t337 and CC9 but showed diversity in antimicrobial resistance patterns and PFGE profiles. All isolates harbored SCCmec IX and were resistant to seven out of 14 tested antimicrobials; additional resistances were found in the pork isolates. Microarray analysis identified blaZ, aac-aphD, vga(A, tetM, and a tet efflux marker, in all strains and additionally ermB and aadD, cat and fex(A in the pork isolates. None of the isolates were found PVL-positive, but enterotoxins were identified in all isolates. This is, to our knowledge, the first description of MRSA in livestock and food products in Thailand and also the first observation of MRSA CC9 associated with SCCmec IX. This study indicates a likely widespread distribution of MRSA in pig and pork in Thailand and further investigation on the prevalence and importance of livestock associated MRSA in Thailand is needed.

  14. [The spa-and-health resort-based rehabilitation of the patients presenting with frequently recurring erosive and ulcerative lesions in the oesophagus, stomach, and duodenum in the phase of subsiding exacerbation].

    Science.gov (United States)

    Efimenko, N V; Kaĭsinova, A S

    2014-01-01

    To develop a new medical technology for the spa-and-health resort-based treatment of the patients presenting with frequently recurring erosive and ulcerative lesions in the oesophagus, stomach, and duodenum in the phase of subsiding exacerbation. A total of 100 patients presenting with frequently recurring erosive and ulcerative lesions in the oesophagus, stomach, and duodenum in the phase of subsiding exacerbation were available for the examination that included detailed investigations of the clinical picture, characteristics of the immune status, and psychological testing before and after a course of the spa-and-health resort-based treatment. The effectiveness of two therapeutic modalities was evaluated. One of them (control) prescribed to 50 patients consisted of standard antiulcer pharmacotherapy in combination with Essentuki Novaya drinking mineral water and carbon dioxide mineral baths, the other given to 50 patients included radon baths instead of carbon dioxide mineral baths. The combined application of drinking mineral waters, radon baths, and standard antiulcer pharmacotherapy produced the most conspicuous clinical effect in the framework of spa-and-health resort-based rehabilitation of the patients presenting with frequently recurring erosive and ulcerative lesions in the oesophagus, stomach, and duodenum in the phase of subsiding exacerbation as confirmed by positive dynamics of their psychoemotional status in 97.7% of the cases, regression of pain syndrome (91.5%), and improvement of humoral and cellular immunity (94%). An important result of the spa-and-health resort-based rehabilitation is the intensification of the reparative processes in gastroduodenal mucosa responsible for the healing of ulcers and erosions in 94.7% of the patients. The spa-and-health resort-based rehabilitation is a pathogenetically sound and efficacious approach to the management of the patients presenting with frequently recurring erosive and ulcerative lesions in the

  15. The Heidelberg Basin Drilling Project — basin analysis

    Science.gov (United States)

    Tanner, David C.; Martini, Nicole; Buness, Hermann; Gabriel, Gerald; Krawczyk, Charlotte M.

    2010-05-01

    Within the context of the Heidelberg Basin Project (Gabriel et al. 2008), we present the first results of three-dimensional structural modelling of the basin, based on interpretation of reflection seismics and decompaction using porosity data measured from core material. Firstly, we interpreted six horizons (Base Quaternary, Internal and Base Pliocene, Base Upper Miocene, Internal and Base Mid Miocene Hydrobien beds) from all available industrial (ca. 100 km) and our own reflection seismic sections (ca. 15 km), which lie within a 8 km radius around the Heidelberg UniNord 1/2 boreholes. This data was used to construct a three-dimensional geometrical model of the Heidelberg Basin. Using 300 core samples, we determined the porosity of the Quaternary sediments and constructed an exponential porosity/depth relationship for these rocks, which were then attributed to the model. Lower strata were given values from the literature. The model shows that the Heidelberg basin has a N-S and E-W areal extent of only 10 × 6 km, directly abutting the eastern fault boundary of the Upper Rhine Graben. The strongest synsedimentary tectonic subsidence occurred during the Upper Miocene, Upper Pliocene, and Quarternary. Faults are not seen within the basin at this level, but a NW-SE striking strike-slip structure is recorded to the west of the basin. Furthermore, the sedimentary depocentre shifted 2 km northwards over time to the present location, directly below the city of Heidelberg. We determined that Quaternary sediments have porosities of over 60% at the surface, but at the Base Quaternary porosity is less than 35%. This strong decrease means that 740 m of sediments were compacted to produce the present ca. 500 m thickness of Quaternary strata. Gabriel, G., Ellwanger, D., Hoselmann, C. & Weidenfeller, M. (2008): The Heidelberg Basin Drilling Project. -- Quaternary Science Journal, 57, 3-4, 253-260.

  16. RESERVES IN WESTERN BASINS PART IV: WIND RIVER BASIN

    Energy Technology Data Exchange (ETDEWEB)

    Robert Caldwell

    1998-04-01

    Vast quantities of natural gas are entrapped within various tight formations in the Rocky Mountain area. This report seeks to quantify what proportion of that resource can be considered recoverable under today's technological and economic conditions and discusses factors controlling recovery. The ultimate goal of this project is to encourage development of tight gas reserves by industry through reducing the technical and economic risks of locating, drilling and completing commercial tight gas wells. This report is the fourth in a series and focuses on the Wind River Basin located in west central Wyoming. The first three reports presented analyses of the tight gas reserves and resources in the Greater Green River Basin (Scotia, 1993), Piceance Basin (Scotia, 1995) and the Uinta Basin (Scotia, 1995). Since each report is a stand-alone document, duplication of language will exist where common aspects are discussed. This study, and the previous three, describe basin-centered gas deposits (Masters, 1979) which contain vast quantities of natural gas entrapped in low permeability (tight), overpressured sandstones occupying a central basin location. Such deposits are generally continuous and are not conventionally trapped by a structural or stratigraphic seal. Rather, the tight character of the reservoirs prevents rapid migration of the gas, and where rates of gas generation exceed rates of escape, an overpressured basin-centered gas deposit results (Spencer, 1987). Since the temperature is a primary controlling factor for the onset and rate of gas generation, these deposits exist in the deeper, central parts of a basin where temperatures generally exceed 200 F and drill depths exceed 8,000 feet. The abbreviation OPT (overpressured tight) is used when referring to sandstone reservoirs that comprise the basin-centered gas deposit. Because the gas resources trapped in this setting are so large, they represent an important source of future gas supply, prompting studies

  17. Testing for Basins of Wada.

    Science.gov (United States)

    Daza, Alvar; Wagemakers, Alexandre; Sanjuán, Miguel A F; Yorke, James A

    2015-11-10

    Nonlinear systems often give rise to fractal boundaries in phase space, hindering predictability. When a single boundary separates three or more different basins of attraction, we say that the set of basins has the Wada property and initial conditions near that boundary are even more unpredictable. Many physical systems of interest with this topological property appear in the literature. However, so far the only approach to study Wada basins has been restricted to two-dimensional phase spaces. Here we report a simple algorithm whose purpose is to look for the Wada property in a given dynamical system. Another benefit of this procedure is the possibility to classify and study intermediate situations known as partially Wada boundaries.

  18. The Central European Permian Basins; Rheological and structural controls on basin history and on inter-basin connectivity

    NARCIS (Netherlands)

    Smit, Jeroen; van Wees, Jan-Diederik; Cloetingh, Sierd

    2014-01-01

    We analyse the relative importance of the major crustal-scale fault zones and crustal architecture in controlling basin formation, deformation and the structural connections between basins. The North and South Permian Basins of Central Europe are usually defined by the extend of Rotliegend

  19. Hydrologic Sub-basins of Greenland

    Data.gov (United States)

    National Aeronautics and Space Administration — The Hydrologic Sub-basins of Greenland data set contains Geographic Information System (GIS) polygon shapefiles that include 293 hydrologic sub-basins of the...

  20. Detention basin alternative outlet design study.

    Science.gov (United States)

    2016-10-01

    This study examines the outlets structures CDOT has historically employed to drain water quality treatment detention basins and flood control basins, presents two new methods of metering the water quality capture volume (WQCV), namely 1) the Elliptic...

  1. Spatial and temporal variability of groundwater recharge in Geba basin, Northern Ethiopia

    Science.gov (United States)

    Yenehun, Alemu; Walraevens, Kristine; Batelaan, Okke

    2017-10-01

    WetSpa, a physically based, spatially distributed watershed model, has been used to study the spatial and temporal variation of recharge in the Geba basin, Northern Ethiopia. The model covers an area of about 4, 249 km2 and integrates elevation, soil and land-use data, hydrometeorological and river discharge data. The Geba basin has a highly variable topography ranging from 1000 to 3280 m with an average slope of 12.9%. The area is characterized by a distinct wet and long dry season with a mean annual precipitation of 681 mm and temperatures ranging between 6.5 °C and 32 °C. The model was simulated on daily basis for nearly four years (January 1, 2000 to December 18, 2003). It resulted in a good agreement between measured and simulated streamflow hydrographs with Nash-Sutcliffe efficiency of almost 70% and 85% for, respectively, the calibration and validation. The water balance terms show very strong spatial and temporal variability, about 3.8% of the total precipitation is intercepted by the plant canopy; 87.5% infiltrates into the soil (of which 13% percolates, 2.7% flows laterally off and 84.2% evapotranspired from the root zone), and 7.2% is surface runoff. The mean annual recharge varies from about 45 mm (2003) to 208 mm (2001), with average of 98.6 mm/yr. On monthly basis, August has the maximum (73 mm) and December the lowest (0.1 mm) recharge. The mean annual groundwater recharge spatially varies from 0 to 371 mm; mainly controlled by the distribution of rainfall amount, followed by soil and land-use, and to a certain extent, slope. About 21% of Geba has a recharge larger than 120 mm and 1% less than 5 mm.

  2. 77 FR 45653 - Yakima River Basin Conservation Advisory Group; Yakima River Basin Water Enhancement Project...

    Science.gov (United States)

    2012-08-01

    ...; Yakima River Basin Water Enhancement Project, Yakima, WA AGENCY: Bureau of Reclamation, Interior. ACTION... Basin Conservation Advisory Group, Yakima River Basin Water Enhancement Project, established by the... future projects being funded with Yakima River Basin Water Enhancement Project funds. The CAG will also...

  3. Canada Basin Acoustic Propagation Experiment (CANAPE)

    Science.gov (United States)

    2015-09-30

    1 DISTRIBUTION STATEMENT A. Approved for public release; distribution is unlimited. Canada Basin Acoustic Propagation Experiment (CANAPE...about Arctic acoustics during the Cold War is now obsolete. The goal of the Canada Basin Acoustic Propagation Experiment (CANAPE) is to determine the...Canada Basin (McLaughlin et al., 2011). These changing conditions make the Canada Basin an ideal location to test the hypothesis put forward by P

  4. Implementing Integrated River Basin Management in China

    NARCIS (Netherlands)

    Boekhorst, D.G.J. te; Smits, A.J.M.; Yu, X.; Lifeng, L.; Lei, G.; Zhang, C.

    2010-01-01

    This paper examines the role of the World Wildlife Fund for Nature China as policy entrepreneur in China. It illustrates the ways in which the World Wildlife Fund for Nature is active in promoting integrated river basin management in the Yangtze River basin and how the efforts at basin level are

  5. Supplementary information on K-Basin sludges

    International Nuclear Information System (INIS)

    MAKENAS, B.J.

    1999-01-01

    Three previous documents in this series have been published covering the analysis of: K East Basin Floor and Pit Sludge, K East Basin Canister Sludge, and K West Basin Canister Sludge. Since their publication, additional data have been acquired and analyses performed. It is the purpose of this volume to summarize the additional insights gained in the interim time period

  6. On the significance of ELF basins

    Indian Academy of Sciences (India)

    Unknown

    to complement to chemical intuition (see, e.g., refs. 2, 3). In a mathematically more rigorous way, such regions, ELF basins,4 were defined following the spirit of Bader's Atoms in Molecules (AIM). All points in space which lead to the a given maximum of ELF, by following the gradient of ELF, belong to the same basin. Basins ...

  7. Supplementary information on K-Basin sludges

    Energy Technology Data Exchange (ETDEWEB)

    MAKENAS, B.J.

    1999-03-15

    Three previous documents in this series have been published covering the analysis of: K East Basin Floor and Pit Sludge, K East Basin Canister Sludge, and K West Basin Canister Sludge. Since their publication, additional data have been acquired and analyses performed. It is the purpose of this volume to summarize the additional insights gained in the interim time period.

  8. Proterozoic intracontinental basin: The Vindhyan example

    Indian Academy of Sciences (India)

    The Vindhyan basin is a classic example of Proterozoic intracontinental basin that developed in the central part of the Indian shield along with several other basins such as Cuddapah,Chattisgarh,etc.The strata are exposed in three major sectors:Son valley,Bundelkhand and Rajasthan. Substantially thick Vindhyan rocks ...

  9. BASIN: Beowulf Analysis Symbolic INterface

    Science.gov (United States)

    Vesperini, Enrico; Goldberg, David M.; McMillan, Stephen L. W.; Dura, James; Jones, Douglas

    2013-08-01

    BASIN (Beowulf Analysis Symbolic INterface) is a flexible, integrated suite of tools for multiuser parallel data analysis and visualization that allows researchers to harness the power of Beowulf PC clusters and multi-processor machines without necessarily being experts in parallel programming. It also includes general tools for data distribution and parallel operations on distributed data for developing libraries for specific tasks.

  10. Great Basin paleoenvironmental studies project

    International Nuclear Information System (INIS)

    1993-01-01

    Project goals, project tasks, progress on tasks, and problems encountered are described and discussed for each of the studies that make up the Great Basin Paleoenvironmental Studies Project for Yucca Mountain. These studies are: Paleobotany, Paleofauna, Geomorphology, and Transportation. Budget summaries are also given for each of the studies and for the overall project

  11. Evolution of the Congo Basin

    Science.gov (United States)

    Glasmacher, U. A.; Bauer, F. U.; Kollenz, S.; Delvaux, D.

    2012-04-01

    The Congo Basin is one of the largest basins in the World with very little knowledge on the geological evolution as well as the oil and gas potential. In the past, oil seeps are recorded in the central part of the basin. Four sides in the Congo basin have been drilled so far. The cores of the two drill sides Dekese and Samba are located at the Musée royal de l'Afrique Centrale, Belgium. In a reconnaissance survey, we sampled both drill cores in a nearly even spacing of ~ 150 m covering the whole stratigraphy from Albian to Proterozoic. The red and green to grey sandstone samples were prepared by usual heavy minerals separation technique. Most of the samples revealed enough apatite and zircon grains for the two thermochronometric techniques fission track and (U-Th-Sm)/He. The time-temperature (t-T) evolution for the two drill locations were modelled by using the determined thermochronological data within the software code HeFTy. We tested various geological evolutionary constrains. Both techniques provide us information on the thermal and exhumation of the possible source area and on the drill location by themselves.

  12. Coastal inlets and tidal basins

    NARCIS (Netherlands)

    De Vriend, H.J.; Dronkers, J.; Stive, M.J.F.; Van Dongeren, A.; Wang, J.H.

    2002-01-01

    lecture note: Tidal inlets and their associated basins (lagoons) are a common feature of lowland coasts all around the world. A significant part ofthe world's coastlines is formed by barrier island coasts, and most other tidal coasts are interrupted by estuaries and lagoon inlets. These tidal

  13. The Amazon Basin in transition

    Science.gov (United States)

    Eric A. Davidson; Alessandro C. de Araujo; Paulo Artaxo; Jennifer K. Balch; I. Foster Brown; Mercedes M.C. Bustamente; Michael T. Coe; Ruth S. DeFriess; Michael Keller; Marcos Longo; J. William Munger; Wilfrid Schroeder; Britaldo Soares-Filho; Carlos M. Souza, Jr.; Steven C. Wofsy

    2012-01-01

    Agricultural expansion and climate variability have become important agents of disturbance in the Amazon basin. Recent studies have demonstrated considerable resilience of Amazonian forests to moderate annual drought, but they also show that interactions between deforestation, fire and drought potentially lead to losses of carbon storage and changes in regional...

  14. [Quality management in a combined clinic - the quality management system according to DIN EN ISO 9001 of the The German Association of Spa Accommodation Resorts e. V. (VdKB)].

    Science.gov (United States)

    Eckert, H; Schulze, U

    2004-06-01

    The implementation of a quality system in health care organizations offers huge potentials for improvement and development. But the realization of such systems necessitates high investments, which small companies and family businesses often are unable to raise. The German Association of Spa Accommodation Resorts (VdKB) commissioned two consultants to develop a reasonably priced implementation concept of a DIN EN ISO 9001 quality system specially adjusted to small companies and family businesses in medical spa and rehabilitation services, which was successfully accredited in May 2003. This paper describes fundamental requirements in combine management systems, considers the pros and cons of management combines and demonstrates the practical realization of combine requirements on the example of the VdKB-combine system.

  15. L-Reactor 186-basin cleaning alternatives

    International Nuclear Information System (INIS)

    Turcotte, M.D.S.

    1983-01-01

    Operation of L Reactor will necessitate annual cleaning of the L Area 186 basins. Alternatives are presented for sediment discharge due to 186-basin cleaning activities as a basis for choosing the optimal cleaning method. Current cleaning activities (i.e. removal of accumulated sediments) for the P, C and K-Area 186 basins result in suspended solids concentrations in the effluent waters above the NPDES limits, requiring an exemption from the NPDES permit for these short-term releases. The objective of mitigating the 186-basin cleaning activities is to decrease the suspended solids concentrations to within permit limits while continuing satisfactory operation of the basins

  16. Prevalence and risk factors of substance use (SPA, in students of secondary education institution in the city of Popayán, Colombia

    Directory of Open Access Journals (Sweden)

    Diego Fernando Hoyos-Samboní

    2013-03-01

    Full Text Available Objective: To describe the prevalence, risk factors and risk perception of psychoactive substance use among students at an educational institution average male in Popayan city. Methods: Descriptive cross-sectional study of a stratified sample of 224 participants from a population of 810 high school students divided in 22 subgroups. Participants registered an instrument type survey divided into four components: sociodemographic characteristics, prevalence of consumption, risk factors, component for which the instrument was adapted from the DUSI (Drug Use Screening Inventory and perception of risk. The results were tabulated through the program "Microsoft Excel". Results: The most commonly used substance is alcohol with consumption in the last month of 9.8%. Alcohol, marijuana, cocaine and amphetamines are substances that are consumed from 6th to 11th grade. Of the nine Risk Factors studied, four were with Moderate Severity: Mental condition, Personal Conduct, relationship with friends and peers, and Health Status. The average perceived "great risk" is 75.1%, being higher for crack users (88% and lowest for alcohol (51.8%. In contrast, the perception of "no risk" and "slight risk" averaged 3.9% and 7.2%, respectively. Conclusion: We found a high intake of alcohol, marijuana and cocaine, and all the high school courses describe contact with SPA. There is a tendency to normalize smoking and alcohol consumption. It’s recommended to work the risk factors that have not yet showing high severity.

  17. [Cardiovascular and hormonal strain in waste collection workers employed in Amsa SpA, municipality of Milan, in permanent day and night work].

    Science.gov (United States)

    Biggi, N; Consonni, D; Fragasso, G; Lattuada, G; Perseghin, G L; Verga, R; Costa, G

    2007-01-01

    Aim of the study is to explore in shiftworkers: a) blood pressure and hormonal variations; b) dyslipidemia and blood glucose levels; c) insulin resistence syndrome. We have assessed 48 male workers employes in Amsa SpA, a large municipal enterprise in charge of street cleaning and domestic waste collection, in permanent day and night work as hand sweepers, motor sweepers and delivery tricar drivers. 24 of those workers (daily and nightly) were normotensive and 24 were hypertensive. Our medical checks were: physical examination: BMI; laboratory findings (blood): glucose, total cholesterol, triglycerides, endothelin, insulin, FFA, HOMA S, HOMA B, HOMA R; assay of salivary cortisol and urinary cortisol in 24 h; 24 h pressure monitoring. Nightly hypertensive: increased consumption in wine and coffee, weight and BMI, total cholesterol and FFA and endothelin. Nightly normotensive: increased consumption in cigarettes and salivary cortisol. Daily hypertensive: increased total cholesterol; 24 h pressure monitoring showed more pronounced variations of pressure in night workers both normotensive and hypertensive in working time. Night shiftwork looks like more stressfull than day shiftwork. Insuline resistance isn't noticed in all four groups.

  18. Modelling Forearc Basin Formation and Stratigraphy

    Science.gov (United States)

    Mannu, Utsav; Ueda, Kosuke; Willett, Sean; Gerya, Taras; Strasser, Michael

    2017-04-01

    Comparison of synthetic stratigraphy of forearc basins as generated in coupled plate subduction and accretionary wedge models to the stratal patterns observed for forearc basins in nature, could be used to ascertain the dynamic consistency of the interpreted deformational history of the wedge. Additionally, it could help us understand the emergence of stratigraphic patterns in forearc basins as an interplay between sedimentary flux and wedge dynamics. Here we present a simple methodology to generate synthetic stratigraphy by emplacing isochronal surfaces during the evolution of the wedge. We use a dynamic 2D, high-resolution, thermo-mechanical, subduction model coupled to an adaptive irregular surface grid to model the free surface. In this model, we track basin stratigraphy developing in the wedge top basins atop the accretionary prism by emplacing lines of Lagrangian markers at discrete times along the upper surface of the model, which subsequently are buried, transported, and deformed according to the velocity field generated in the model. We conduct numerical experiments to identify the stratigraphic signatures of different forearc basin formation mechanisms. We also study the impact of hinterland and trench sedimentation on the wedge evolution and its impact on forearc basin formation. Forearc basins that form on top of the overriding plate remain passive to the deformation history of the wedge. Forearc basins formed as negative alpha basins remain mostly undeformed. Forearc basins that form due to wedge stabilization exhibit landward tilting of strata with time. We also find that trench sedimentation enhances the landward tilting of the basin by shifting deformation landwards and potentially triggering out-of-sequence-thrust emergence/reactivation. Predicted stratigraphic features in our numerical models agree well with stratigraphic patterns observed in different types of forearc basins in the Nankai Trough, Sunda Strait and Lombok Basin offshore Japan, Java

  19. THE ADVANCED CHEMISTRY BASINS PROJECT

    Energy Technology Data Exchange (ETDEWEB)

    William Goddard; Peter Meulbroek; Yongchun Tang; Lawrence Cathles III

    2004-04-05

    In the next decades, oil exploration by majors and independents will increasingly be in remote, inaccessible areas, or in areas where there has been extensive shallow exploration but deeper exploration potential may remain; areas where the collection of data is expensive, difficult, or even impossible, and where the most efficient use of existing data can drive the economics of the target. The ability to read hydrocarbon chemistry in terms of subsurface migration processes by relating it to the evolution of the basin and fluid migration is perhaps the single technological capability that could most improve our ability to explore effectively because it would allow us to use a vast store of existing or easily collected chemical data to determine the major migration pathways in a basin and to determine if there is deep exploration potential. To this end a the DOE funded a joint effort between California Institute of Technology, Cornell University, and GeoGroup Inc. to assemble a representative set of maturity and maturation kinetic models and develop an advanced basin model able to predict the chemistry of hydrocarbons in a basin from this input data. The four year project is now completed and has produced set of public domain maturity indicator and maturation kinetic data set, an oil chemistry and flash calculation tool operable under Excel, and a user friendly, graphically intuitive basin model that uses this data and flash tool, operates on a PC, and simulates hydrocarbon generation and migration and the chemical changes that can occur during migration (such as phase separation and gas washing). The DOE Advanced Chemistry Basin Model includes a number of new methods that represent advances over current technology. The model is built around the concept of handling arbitrarily detailed chemical composition of fluids in a robust finite-element 2-D grid. There are three themes on which the model focuses: chemical kinetic and equilibrium reaction parameters, chemical

  20. SMART-1 Results and Lessons for Future Exploration

    Science.gov (United States)

    Foing, B. H.

    2009-04-01

    Jan 2005 solar flare, permitting the first detection of Calcium from lunar orbit [9]. Bulk crustal composition has bearing on theories of origin and evolution of the Moon. D-CIXS produced the first global measurements of the lunar surface in X-ray fluorescence (XRF), elemental abundances of Mg, Al and Si (and Fe when solar activity permitted) across the whole Moon. The South Pole-Aitken Basin (SPA) and large lunar impact basins have been also measured with D-CIXS. D-CIXS has been improved for the C1XS instrument adapted to ISRO Chandrayaan-1. SIR (Smart-1 Infra-Red Spectrometer). SIR has been operating in the 0.9-2.6 μm wavelength range and carrying out mineralogical survey of the lunar crust. SIR had high enough spectral resolution to separate the pyroxene and olivine signatures in lunar soils. SIR data with spatial resolution as good as 400 m permitted to distinguish units on central peaks, walls, rims and ejecta blankets of large impact craters, allowing for stratigraphic studies of the lunar crust. SIR has been improved for the Chandrayaan-1 SIR2 instrument. SMART-1 overall planetary science: SMART-1 science investigations included studies of the chemical composition of the Moon, of geophysical processes (volcanism, tectonics, cratering, erosion, deposition of ices and volatiles) for comparative planetology, and high resolution studies in preparation for future steps of lunar exploration. The mission addressed several topics such as the accretional processes that led to the formation of rocky planets, and the origin and evolution of the Earth-Moon system [8]. SMART-1 operations and coordination: The Experiments have been run according to illumination and altitude conditions during the nominal science phase of 6-months and 1 yr extension, in elliptical Moon orbit. The planning and co-ordination of the Technology and science experiments operations was carried out at ESA/ESTEC (SMART-1 STOC). The data archiving is based on the PDS (Planetary Data System) Standard

  1. The sedimentary basins of Tanzania - reviewed

    Science.gov (United States)

    Mbede, E. I.

    The sedimentary basins of Tanzania have been classified into four morphotectonic groups: the coastal basin, the Karoo rift basins, basins found within the present East African rift valley and the cratonic sag basins. Except for the cratonic sag basins, each of these basin group has been affected by rifting at one time or another. The geology of each basin is discussed, structural evolution is evaluated and the prospectivity is thence looked into. Coal is exploited at Songwe-Kiwira coalfield and is found in potentially economic quantities in other Karoo basins. Prospecting for hydrocarbon resources has been going on since the 50s. Gas has been discovered in Songosongo and Mnazi bay fields, uneconomical quantities of oil have also been reported in Songosongo. Being basically rift basins which have reached different stages of development, source rocks normally associated with Initial-rifting, synrifting as well as post-rifting processes are probably well developed. Reservoir rocks, traps and cap rocks are normally not rare in such tectonic environments. Thermal gradients associated with the rifting stage are normaly high to effect maturation of source rocks even at low sedimentary thicknesses. Studies done so far are still inconclusive, because while testing has mainly been focused on structural traps stratigraphic traps seems to be more promising.

  2. Uranium geochemistry of Orca Basin

    International Nuclear Information System (INIS)

    Weber, F.F. Jr.; Sackett, W.M.

    1981-01-01

    Orca Basin, an anoxic, brine-filled depression at a depth of 2200 m in the Northwestern Gulf of Mexico continental slope, has been studied with respect to its uranium geochemistry. Uranium concentration profiles for four cores from within the basin were determined by delayed-neutron counting. Uranium concentrations ranged from 2.1 to 4.1 ppm on a salt-free and carbonate-corrected basis. The highest uranium concentrations were associated with the lowest percentage and delta 13 C organic carbon values. For comparison, cores from the brine-filled Suakin and Atlantis II Deeps, both in the Red Sea, were also analyzed. Uranium concentrations ranged from 1.2 to 2.6 ppm in the Suakin Deep and from 8.0 to 11.0 ppm in the Atlantis II Deep. No significant correlation was found between uranium concentrations and organic carbon concentrations and delta 13 C values for these cores. Although anoxic conditions are necessary for significant uranium uptake by non-carbonate marine sediments, other factors such as dilution by rapidly depositing materials and uranium supply via mixing and diffusion across density gradients may be as important in determining uranium concentrations in hypersaline basin sediments. (author)

  3. K West Basin canister survey

    International Nuclear Information System (INIS)

    Pitner, A.L.

    1998-01-01

    A survey was conducted of the K West Basin to determine the distribution of canister types that contain the irradiated N Reactor fuel. An underwater camera was used to conduct the survey during June 1998, and the results were recorded on videotape. A full row-by-row survey of the entire basin was performed, with the distinction between aluminum and stainless steel Mark 1 canisters made by the presence or absence of steel rings on the canister trunions (aluminum canisters have the steel rings). The results of the survey are presented in tables and figures. Grid maps of the three bays show the canister lid ID number and the canister type in each location that contained fuel. The following abbreviations are used in the grid maps for canister type designation: IA = Mark 1 aluminum, IS = Mark 1 stainless steel, and 2 = Mark 2 stainless steel. An overall summary of the canister distribution survey is presented in Table 1. The total number of canisters found to contain fuel was 3842, with 20% being Mark 1 Al, 25% being Mark 1 SS, and 55% being Mark 2 SS. The aluminum canisters were predominantly located in the East and West bays of the basin

  4. The geologic history of Margaritifer basin, Mars

    Science.gov (United States)

    Salvatore, M. R.; Kraft, M. D.; Edwards, Christopher; Christensen, P.R.

    2016-01-01

    In this study, we investigate the fluvial, sedimentary, and volcanic history of Margaritifer basin and the Uzboi-Ladon-Morava (ULM) outflow channel system. This network of valleys and basins spans more than 8000 km in length, linking the fluvially dissected southern highlands and Argyre Basin with the northern lowlands via Ares Vallis. Compositionally, thermophysically, and morphologically distinct geologic units are identified and are used to place critical relative stratigraphic constraints on the timing of geologic processes in Margaritifer basin. Our analyses show that fluvial activity was separated in time by significant episodes of geologic activity, including the widespread volcanic resurfacing of Margaritifer basin and the formation of chaos terrain. The most recent fluvial activity within Margaritifer basin appears to terminate at a region of chaos terrain, suggesting possible communication between surface and subsurface water reservoirs. We conclude with a discussion of the implications of these observations on our current knowledge of Martian hydrologic evolution in this important region.

  5. Exergetic efficiency of basin type solar still

    Science.gov (United States)

    Layek, Apurba

    2017-06-01

    Simplicity of solar distillation system makes it very attractive, but the yield as well as the thermal efficiency is very low. Different types of absorbing materials e.g. black ink, black dye solution in basin water and black toner on water surface were used to evaluate their effect on the yield. As the absorbing material absorbs more solar radiation and increases basin water temperature, increases yield as well as energy efficiency. To enhance the thermal performance, and to have the insight of thermal losses; exergetic analysis of solar still is done. The maximum energy efficiency obtained for basin water having these absorber material on basin water are about 41.3 %, 43.42 % and 45.79 %, while exergetic efficiency values are 5.91%, 6.34 % and 7.10 % respectively. Exergy destruction from basin liner is the highest compared to that from basin water and glazing.

  6. Reserves in western basins: Part 1, Greater Green River basin

    Energy Technology Data Exchange (ETDEWEB)

    1993-10-01

    This study characterizes an extremely large gas resource located in low permeability, overpressured sandstone reservoirs located below 8,000 feet drill depth in the Greater Green River basin, Wyoming. Total in place resource is estimated at 1,968 Tcf. Via application of geologic, engineering and economic criteria, the portion of this resource potentially recoverable as reserves is estimated. Those volumes estimated include probable, possible and potential categories and total 33 Tcf as a mean estimate of recoverable gas for all plays considered in the basin. Five plays (formations) were included in this study and each was separately analyzed in terms of its overpressured, tight gas resource, established productive characteristics and future reserves potential based on a constant $2/Mcf wellhead gas price scenario. A scheme has been developed to break the overall resource estimate down into components that can be considered as differing technical and economic challenges that must be overcome in order to exploit such resources: in other words, to convert those resources to economically recoverable reserves. Total recoverable reserves estimates of 33 Tcf do not include the existing production from overpressured tight reservoirs in the basin. These have estimated ultimate recovery of approximately 1.6 Tcf, or a per well average recovery of 2.3 Bcf. Due to the fact that considerable pay thicknesses can be present, wells can be economic despite limited drainage areas. It is typical for significant bypassed gas to be present at inter-well locations because drainage areas are commonly less than regulatory well spacing requirements.

  7. Reserve estimates in western basins. Part 2: Piceance Basin

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-10-01

    This study characterizes an extremely large gas resource located in low permeability, sandstone reservoirs of the Mesaverde group in the Piceance Basin, Colorado. Total in place resource is estimated at 307.3 Tcf. Via application of geologic, engineering and economic criteria, the portion of this resource potentially recoverable as reserves is estimated. Those volumes estimated include probable, possible and potential categories and total 5.8 Tcf as a mean estimate of recoverable gas for all plays considered in the basin. About 82.6% of the total evaluated resource is contained within sandstones that have extremely poor reservoir properties with permeabilities considered too low for commerciality using current frac technology. Cost reductions and technology improvements will be required to unlock portions of this enormous resource. Approximately 2.7% of the total resource is contained within sandstone reservoirs which do not respond to massive hydraulic fracture treatments, probably due to their natural lenticular nature. Approximately 6.8% of the total resource is located in deeply buried settings below deepest established production. Approximately 7.9% of the total resource is considered to represent tight reservoirs that may be commercially exploited using today`s hydraulic fracturing technology. Recent technology advances in hydraulic fracturing practices in the Piceance Basin Mesaverde has resulted in a marked improvement in per well gas recovery which, where demonstrated, has been incorporated into the estimates provided in this report. This improvement is so significant in changing the risk-reward relationship that has historically characterized this play, that previously uneconomic areas and resources will graduate to the economically exploitable category. 48 refs., 96 figs., 18 tabs.

  8. Determination of fat content in chicken hamburgers using NIR spectroscopy and the Successive Projections Algorithm for interval selection in PLS regression (iSPA-PLS)

    Science.gov (United States)

    Krepper, Gabriela; Romeo, Florencia; Fernandes, David Douglas de Sousa; Diniz, Paulo Henrique Gonçalves Dias; de Araújo, Mário César Ugulino; Di Nezio, María Susana; Pistonesi, Marcelo Fabián; Centurión, María Eugenia

    2018-01-01

    Determining fat content in hamburgers is very important to minimize or control the negative effects of fat on human health, effects such as cardiovascular diseases and obesity, which are caused by the high consumption of saturated fatty acids and cholesterol. This study proposed an alternative analytical method based on Near Infrared Spectroscopy (NIR) and Successive Projections Algorithm for interval selection in Partial Least Squares regression (iSPA-PLS) for fat content determination in commercial chicken hamburgers. For this, 70 hamburger samples with a fat content ranging from 14.27 to 32.12 mg kg- 1 were prepared based on the upper limit recommended by the Argentinean Food Codex, which is 20% (w w- 1). NIR spectra were then recorded and then preprocessed by applying different approaches: base line correction, SNV, MSC, and Savitzky-Golay smoothing. For comparison, full-spectrum PLS and the Interval PLS are also used. The best performance for the prediction set was obtained for the first derivative Savitzky-Golay smoothing with a second-order polynomial and window size of 19 points, achieving a coefficient of correlation of 0.94, RMSEP of 1.59 mg kg- 1, REP of 7.69% and RPD of 3.02. The proposed methodology represents an excellent alternative to the conventional Soxhlet extraction method, since waste generation is avoided, yet without the use of either chemical reagents or solvents, which follows the primary principles of Green Chemistry. The new method was successfully applied to chicken hamburger analysis, and the results agreed with those with reference values at a 95% confidence level, making it very attractive for routine analysis.

  9. Report on survey in fiscal 1998 for preservation of Jozankei Spa (second report); 1998 nendo Jouzankei onsen hozen chosa hokokusho. 2

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-11-01

    This paper describes the report on the survey in fiscal 1998 for preservation of Jozankei Spa (the second report). The hot spring area is located on the periphery of relative elevation area on the western side of a fault growing on the boundary of dikes constituting the lower part of the Jozankei quartz porphyry, with the fault forming a boundary. The fault peripheral beds have cracks develop nearly parallel to the fault. The low specific resistance anomaly extracted at underground depth from 100 to 500 m in the area south of the hot spring gushing area forms the clay alteration zone around the hot spring water and cracks arising from the opening type cracks formed around the weak lines of dikes, faults, and surface of unconformity. The hot spring originated water having risen and passed through fractures from deep underground section stagnates in these crack groups, and forms hot spring aquifer. The water is considered to have such nature as temperature of 120 degrees C, chlorine at 1,600 mg/l and tritium concentration of 2.1 to 2.5 TU. The water is characterized by eluation constituents from the Usubetsu bed. The hot spring water in the aquifer rises passing through the opening cracks in the upper part, wherein the water not mixing with ground water does not have the constituents change, and the mixed water changes the nature of the hot spring water. In the surface layer, the water flows through intersecting joints growing around the fracture, and gushes out of the ground. (NEDO)

  10. Moon taken by Galileo after completing its first Earth Gravity Assist

    Science.gov (United States)

    1990-01-01

    Galileo spacecraft images of the Moon were taken at (right photo) 6:47 pm Pacific Standard Time (PST), 12-08-90, and at (left photo) 9:35 am PST, 12-09-90, at a range of more than 350,000 miles. The picture on the right shows the dark Oceanus Procellarum in the upper center, with Mare Imbrium above it and the smaller circular Mare Humorum below. The Orientale Basin, with a small mare in its center, is on the lower left near the limb or edge. Between stretches the cratered highland terrain, with scattered bright young craters on highlands and maria alike. The picture at left shows the globe of the Moon rotated, putting Mare Imbrium on the eastern limb and moving the Orientale Basin almost to the center. The extent of the cratered highlands on the far side is very apparent. At lower left, near the limb, is the South-Pole-Aitken basin, similar to Orientale but very much older and some 1,200 miles in diameter. This feature was previously known as a large depression in the southern far side

  11. Hydroclimatology of the Missouri River basin

    Science.gov (United States)

    Wise, Erika K.; Woodhouse, Connie A.; McCabe, Gregory; Pederson, Gregory T.; St. Jacques, Jeannine-Marie

    2018-01-01

    Despite the importance of the Missouri River for navigation, recreation, habitat, hydroelectric power, and agriculture, relatively little is known about the basic hydroclimatology of the Missouri River basin (MRB). This is of particular concern given the droughts and floods that have occurred over the past several decades and the potential future exacerbation of these extremes by climate change. Here, observed and modeled hydroclimatic data and estimated natural flow records in the MRB are used to 1) assess the major source regions of MRB flow, 2) describe the climatic controls on streamflow in the upper and lower basins , and 3) investigate trends over the instrumental period. Analyses indicate that 72% of MRB runoff is generated by the headwaters in the upper basin and by the lowest portion of the basin near the mouth. Spring precipitation and temperature and winter precipitation impacted by changes in zonal versus meridional flow from the Pacific Ocean play key roles in surface water supply variability in the upper basin. Lower basin flow is significantly correlated with precipitation in late spring and early summer, indicative of Atlantic-influenced circulation variability affecting the flow of moisture from the Gulf of Mexico. Although increases in precipitation in the lower basin are currently overriding the effects of warming temperatures on total MRB flow, the upper basin’s long-term trend toward decreasing flows, reduction in snow versus rain fraction, and warming spring temperatures suggest that the upper basin may less often provide important flow supplements to the lower basin in the future.

  12. New TNX Seepage Basin: Environmental information document

    International Nuclear Information System (INIS)

    Dunaway, J.K.W.; Johnson, W.F.; Kingley, L.E.; Simmons, R.V.; Bledsoe, H.W.

    1986-12-01

    The New TNX Seepage Basin has been in operation at the Savannah River Plant (SRP) since 1980 and is located in the southeastern section of the TNX facility. The basin receives waste from pilot scale tests conducted at TNX in support of the Defense Waste Processing Facility (DWPF) and the plant Separations area. The basin is scheduled for closure after the TNX Effluent Treatment Plant (ETP) begins operation. The basin will be closed pursuant to all applicable state and federal regulations. A statistical analysis of monitoring data indicates elevated levels of sodium and zinc in the groundwater at this site. Closure options considered for the New TNX Seepage Basin include waste removal and closure, no waste removal and closure, and no action. The two predominant pathways for human exposure to chemical contaminants are through surface, subsurface, and atmospheric transport. Modeling calculations were made to determine the risks to human population via these general pathways for the three postulated closure options for the New TNX Seepage Basin. Cost estimates for each closure option at the basin have also been prepared. An evaluation of the environmental impacts from the New TNX Seepage Basin indicate that the relative risks to human health and ecosystems for the postulated closure options are low. The transport of six chemical and one radionuclide constituents through the environmental pathways from the basin were modeled. The maximum chemical carcinogenic risk and the noncarcinogenic risk for the groundwater pathways were from exposure to trichloromethane and nitrate

  13. Relating petroleum system and play development to basin evolution: West African South Atlantic basins

    NARCIS (Netherlands)

    Beglinger, S.E.; Doust, H.; Cloetingh, S.A.P.L.

    2012-01-01

    Sedimentary basins can be classified according to their structural genesis and evolutionary history and the latter can be linked to petroleumsystem and playdevelopment. We propose an approach in which we use the established concepts in a new way: breaking basins down into their natural basin cycle

  14. Fractal basin boundaries generated by basin cells and the geometry of mixing chaotic flows

    NARCIS (Netherlands)

    Nusse, HE; Yorke, JA

    2000-01-01

    Experiments and computations indicate that mixing in chaotic flows generates certain coherent spatial structures. Lf a two-dimensional basin has a basin cell (a trappings region whose boundary consists of pieces of the stable and unstable manifold of some periodic orbit) then the basin consists of a

  15. Suceava Anthropic Torrential Basin - Prolegomena

    Directory of Open Access Journals (Sweden)

    Andrei-Emil BRICIU

    2010-05-01

    Full Text Available One problem discussed by urban hydrology today is the draining influence of the modern cities over the natural drainage systems. The increasing urban areas and of their imperviousness all over theworld is linked to floods shape modifications and unpredicted systemic implications.  Generally, the draining influence of a city over its environment begins when it has a surface great enough to create an anthropic-generated runoff during a rain with enoughprecipitations to provoke waters accumulation into street torrents. The size, imperviousness, precipitations, drainage system and water consumption of the Suceava city are analysed in order to estimate the discharge of the city into Suceava river at various rainfalls. The article is structured as follows:1. Argumentation on the class separation between natural and anthropic torrential basins.2. Placing Suceava city as one of the torrential anthropic basins in Romania using basic arguments.3. Extending one of the argument, the importance of the rainfalls, in more detailed discussions (rainfall characteristics mainly, but also its cumulative effect with the floods on the Suceava river and the consumption of water in the city, with two scenarios. 4. The city is analysed as being integrated into a metropolitan area which can exacerbate the influence of the main city over the surrounding natural drainage basins nearby that area.5. Conclusions, where measures are proposed in order to diminish the potential negative effects on environment and human society.This article is only an introduction to a more detailed analysis which will be complete with further field data.

  16. Mysteries Of The Farside Of The Moon: What Galileo Couldn't See

    Science.gov (United States)

    Pieters, Carlé M.

    When Galileo first turned his improved spyglass to view the Moon from Padua, he was astounded at what he saw: ``And it is like the face of the Earth itself … which is marked here and there with chains of mountains and depths of valleys'' (Galilei, 1610). His remarks about his new discoveries captured the joy which ultimately drives every planetary explorer: ``I render infinite thanks to God for being so kind as to make me alone the first observer of marvels kept hidden in obscurity for all previous centuries'' (Galilei, 1610). Four centuries later his intellectual heirs have expanded human understanding of our place in the universe with an elegant symmetry. The Apollo and Luna programs demonstrated that the origin and history of the Earth and the Moon are intimately linked. Two decades later the Galileo spacecraft swung by the Moon to obtain a gravity-assist from Earth in order to complete its exploration journey to Jupiter and the Galilean satellites. The Galileo spacecraft was the first to return to the Moon with modern sensors, and its brief passage provided dramatic evidence that the farside of the Moon held secrets unimagined from study of the nearside. Subsequent missions, Clementine and Lunar Prospector, provided the first global assessment of lunar topography and composition, and placed the farside in context. There are few of the extensive plains of basaltic lava on the farside of the Moon. This fact is clearly a product of the earliest history of the Moon (the first 500 My), the details of which are being investigated from clues that remain on the Moon today. The dominant feature on the lunar farside is the enormous South Pole-Aitken Basin, which extends from the south pole to the crater Aitken, just 15° south of the equator. This basin includes the deepest area on the Moon and appears as a slightly darker circular region encompassing the lower half of the lunar farside. The composition of the interior is uniquely enriched with iron-bearing minerals

  17. Delaware Basin Monitoring Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    Washington Regulatory and Environmental Services; Washington TRU Solutions LLC

    2001-09-28

    The Delaware Basin Drilling Surveillance Program (DBDSP) is designed to monitor drilling activities in the vicinity of the Waste Isolation Pilot Plant (WIPP). This program is based on Environmental Protection Agency (EPA) requirements. EPA requires the Department of Energy (DOE) to demonstrate the expected performance of the disposal system using a probabilistic risk assessment or performance assessment (PA). This PA must show that the expected repository performance will not release radioactive material above limits set by the EPA's standard and must consider inadvertent drilling into the repository at some future time.

  18. K Basins Field Verification Program

    International Nuclear Information System (INIS)

    Booth, H.W.

    1994-01-01

    The Field Verification Program establishes a uniform and systematic process to ensure that technical information depicted on selected engineering drawings accurately reflects the actual existing physical configuration. This document defines the Field Verification Program necessary to perform the field walkdown and inspection process that identifies the physical configuration of the systems required to support the mission objectives of K Basins. This program is intended to provide an accurate accounting of the actual field configuration by documenting the as-found information on a controlled drawing

  19. Delaware Basin Monitoring Annual Report

    International Nuclear Information System (INIS)

    2001-01-01

    The Delaware Basin Drilling Surveillance Program (DBDSP) is designed to monitor drilling activities in the vicinity of the Waste Isolation Pilot Plant (WIPP). This program is based on Environmental Protection Agency (EPA) requirements. EPA requires the Department of Energy (DOE) to demonstrate the expected performance of the disposal system using a probabilistic risk assessment or performance assessment (PA). This PA must show that the expected repository performance will not release radioactive material above limits set by the EPA's standard and must consider inadvertent drilling into the repository at some future time.

  20. Stratigraphic Signatures of Forearc Basin Formation Mechanisms

    Science.gov (United States)

    Mannu, U.; Ueda, K.; Gerya, T.; Willett, S.; Strasser, M.

    2014-12-01

    Forearc basins are loci of active sedimentation above the landward portion of accretionary prisms. Although these basins typically remain separated from the frontal prism by a forearc high, their evolution has a significant impact on the structure and deformation of the entire wedge. Formation of forearc basins has been proposed as a consequence of changes in wedge stability due to an increase of slab dip in subduction zones. Another hypothesis attributes this to higher hinterland sedimentation, which causes the rear of the wedge to stabilize and eventually develop a forearc basin. Basin stratigraphic architecture, revealed by high-resolution reflection seismic data and borehole data allows interpretation of structural development of the accretionary prism and associated basins with the goal of determining the underlying driving mechanism(s) of basin formation. In this study we supplement data interpretation with thermo-mechanical numerical models including high-resolution isochronal surface tracking to visualize the developing stratigraphy of basins that develop in subduction zone and wedge dynamic models. We use a dynamic 2D thermo mechanical model incorporating surface processes, strain weakening and sediment subduction. The model is a modification of I2VIS model, which is based on conservative, fully staggered finite differences and a non-diffusive marker- in-cell technique capable of modelling mantle convection. In the model different driving mechanisms for basin formation can be explored. Stratigraphic simulations obtained by isochronal surface tracking are compared to reflection pattern and stratigraphy of seismic and borehole data, respectively. Initial results from a model roughly representing the Nankai Trough Subduction Zone offshore Japan are compared to available seismic and Integrated Ocean Drilling (IODP) data. A calibrated model predicting forearc basin stratigraphy will be used to discern the underlying process of basins formation and wedge

  1. Predominance of Three Closely Related Methicillin-Resistant Staphylococcus aureus Clones Carrying a Unique ccrC-Positive SCCmec type III and the Emergence of spa t304 and t690 SCCmec type IV pvl+MRSA Isolates in Kinta Valley, Malaysia.

    Science.gov (United States)

    Ho, Wai-Yew; Choo, Quok-Cheong; Chew, Choy-Hoong

    2017-03-01

    We investigated the epidemiology and clonality of 175 nonrepetitive methicillin-resistant Staphylococcus aureus (MRSA) isolates from clinical specimens collected between 2011 and 2012 in Kinta Valley in Malaysia. Molecular tools such as polymerase chain reaction, pulsed-field gel electrophoresis, and staphylococcal protein A (spa) typing were used. Our study revealed the predominance of three closely related ermA + SCCmec type III pulsotypes belonging to spa type t037 (Brazilian-Hungarian clone), which were deficient in the locus F, but positive for the ccrC gene in majority (65.7%) of the MRSA infections in this region. The first evidence of SCCmec type II MRSA in the country, belonging to spa type t2460, was also noted. Although the carriage of pvl gene was uncommon (8.6%) and mostly confined to either SCCmec type IV or SCCmec type V isolates, most of these isolates belonged to spa types t345 or t657, which are associated with the Bengal-Bay CA-MRSA clone. Interestingly, spa t304 and t690 SCCmec type IV pvl + were also detected among the MRSA isolates. Data from this study show the rise of uncommon clones among MRSA isolates in Malaysia.

  2. [The influence of the comprehensive spa and health resort-based treatment on the system of hormonal regulation in the women presenting with gynecological pathology depending on the plasma prolactin level].

    Science.gov (United States)

    Kaladze, N N; Boldyreva, O A

    The objective of the present study was to evaluate the influence of the comprehensive spa and health resort-based treatment on the system of hormonal regulation in the women presenting with bacterial vaginosis and concomitant chronic inflammatory diseases of the pelvic organs depending on the plasma prolactin level. We investigated the indicators of hormonal regulation in 186 women suffering from bacterial vaginosis and concomitant chronic inflammatory diseases of the pelvic organs depending on the level of prolactin in blood plasma. The first group consisted of 128 women with the normal plasma prolactin levels whereas the second group was comprised of 58 women having hyperprolactinemia. The relevant laboratory data were obtained before and after peloid therapy. The application of the therapeutic peloids for the treatment of the women presenting with the normal level of prolactin in blood plasma was shown to contribute to the positive clinical dynamics of the patients' condition and have a modulating effect on the level of pituitary hormones as well as a stimulating effect on the function of the ovaries. The peloid therapy given to the women with hyperprolactinemia exacerbates the hormonal imbalance as a result of the increase of the initial level of prolactin, discoordination of the hormonal regulation at the level of the pituitary-ovarian system, and enhancement of the adrenal gland function regardless of the level of prolactin. The results of the study give evidence of the possibility to use the plasma prolactin level as an indicator of the effectiveness of the spa and health resort-based treatment of the women presenting with gynecological pathology. Moreover, they suggest the necessity of a differentiated approach to the application of the therapeutic peloids for the treatment of gynecological patients with the disturbances of the hormonal regulation taking into consideration the initial level of prolactin in the blood plasma and the presence of

  3. Basin Assessment Spatial Planning Platform

    Energy Technology Data Exchange (ETDEWEB)

    2017-07-26

    The tool is intended to facilitate hydropower development and water resource planning by improving synthesis and interpretation of disparate spatial datasets that are considered in development actions (e.g., hydrological characteristics, environmentally and culturally sensitive areas, existing or proposed water power resources, climate-informed forecasts). The tool enables this capability by providing a unique framework for assimilating, relating, summarizing, and visualizing disparate spatial data through the use of spatial aggregation techniques, relational geodatabase platforms, and an interactive web-based Geographic Information Systems (GIS). Data are aggregated and related based on shared intersections with a common spatial unit; in this case, industry-standard hydrologic drainage areas for the U.S. (National Hydrography Dataset) are used as the spatial unit to associate planning data. This process is performed using all available scalar delineations of drainage areas (i.e., region, sub-region, basin, sub-basin, watershed, sub-watershed, catchment) to create spatially hierarchical relationships among planning data and drainages. These entity-relationships are stored in a relational geodatabase that provides back-end structure to the web GIS and its widgets. The full technology stack was built using all open-source software in modern programming languages. Interactive widgets that function within the viewport are also compatible with all modern browsers.

  4. Fractal basins in an ecological model

    Directory of Open Access Journals (Sweden)

    I. Djellit

    2013-09-01

    Full Text Available Complex dynamics is detected in an ecological model of host-parasitoid interaction. It illustrates fractalization of basins with self-similarity and chaotic attractors. This paper describes these dynamic behaviors, bifurcations, and chaos. Fractals basins are displayed by numerical simulations.

  5. sedimentology, depositional environments and basin evolution

    African Journals Online (AJOL)

    Preferred Customer

    ABSTRACT: The Inter-Trappean coal and oil shale-bearing sedimentation in the Delbi-Moye Basin took place in tectonically controlled grabens and half-grabens formed by extensional fault systems and accompanied by passive subsidence. The sedimentation history of the basin is related to the tectonic events that affected ...

  6. K-Basin isolation barrier seal

    International Nuclear Information System (INIS)

    Ruff, E.S.

    1994-10-01

    This report documents various aspects of the design, analysis, procurement, and fabrication of the hydraulic seal on the isolation barriers to be installed in the 100-K Area spent nuclear fuel basin. The isolation barrier is used to keep water in the basin in the event of an earthquake

  7. Attractors and basins of dynamical systems

    Directory of Open Access Journals (Sweden)

    Attila Dénes

    2011-03-01

    Full Text Available There are several programs for studying dynamical systems, but none of them is very useful for investigating basins and attractors of higher dimensional systems. Our goal in this paper is to show a new algorithm for finding even chaotic attractors and their basins for these systems. We present an implementation and examples for the use of this program.

  8. Sedimentology, depositional environments and basin evolution of ...

    African Journals Online (AJOL)

    The Inter-Trappean coal and oil shale-bearing sedimentation in the Delbi-Moye Basin took place in tectonically controlled grabens and half-grabens formed by extensional fault systems and accompanied by passive subsidence. The sedimentation history of the basin is related to the tectonic events that affected East Africa.

  9. Implementing Integrated River Basin Management in China

    Directory of Open Access Journals (Sweden)

    Dorri G. J. te Boekhorst

    2010-06-01

    Full Text Available This paper examines the role of the World Wildlife Fund for Nature China as policy entrepreneur in China. It illustrates the ways in which the World Wildlife Fund for Nature is active in promoting integrated river basin management in the Yangtze River basin and how the efforts at basin level are matched with the advice of the China Council for International Cooperation on Environment and Development task force on integrated river basin management to the national government of China. This article demonstrates that the World Wildlife Fund for Nature uses various strategies of different types to support a transition process towards integrated river basin management. Successful deployment of these strategies for change in environmental policy requires special skills, actions, and attitudes on the part of the policy entrepreneur, especially in China, where the government has a dominant role regarding water management and the position of policy entrepeneurs is delicate.

  10. Delaware Basin Monitoring Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    Washington Regulatory and Environmental Services; Washington TRU Solutions LLC

    2002-09-21

    The Delaware Basin Drilling Surveillance Program (DBDSP) is designed to monitor drilling activities in the vicinity of the Waste Isolation Pilot Plant (WIPP). This program is based on Environmental Protection Agency (EPA) requirements. The EPA environmental standards for the management and disposal of transuranic (TRU) radioactive waste are codified in 40 CFR Part 191 (EPA 1993). Subparts B and C of the standard address the disposal of radioactive waste. The standard requires the Department of Energy (DOE) to demonstrate the expected performance of the disposal system using a probabilistic risk assessment or performance assessment (PA). This PA must show that the expected repository performance will not release radioactive material above limits set by the EPA's standard. This assessment must include the consideration of inadvertent drilling into the repository at some future time.

  11. Delaware Basin Monitoring Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    Washington Regulatory and Environmental Services; Washington TRU Solutions LLC

    2003-09-30

    The Delaware Basin Drilling Surveillance Program (DBDSP) is designed to monitor drilling activities in the vicinity of the Waste Isolation Pilot Plant (WIPP). This program is based on Environmental Protection Agency (EPA) requirements. The EPA environmental standards for the management and disposal of transuranic (TRU) radioactive waste are codified in 40 CFR Part 191 (EPA 1993). Subparts B and C of the standard address the disposal of radioactive waste. The standard requires the Department of Energy (DOE) to demonstrate the expected performance of the disposal system using a probabilistic risk assessment or performance assessment (PA). This PA must show that the expected repository performance will not release radioactive material above limits set by the EPA's standard. This assessment must include the consideration of inadvertent drilling into the repository at some future time.

  12. Delaware Basin Monitoring Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    Washington Regulatory and Environmental Services; Washington TRU Solutions LLC

    2005-09-30

    The Delaware Basin Drilling Surveillance Program (DBDSP) is designed to monitor drilling activities in the vicinity of the Waste Isolation Pilot Plant (WIPP). This program is based on Environmental Protection Agency (EPA) requirements. The EPA environmental standards for the management and disposal of transuranic (TRU) radioactive waste are codified in 40 CFR Part 191 (EPA 1993). Subparts B and C of the standard address the disposal of radioactive waste. The standard requires the Department of Energy (DOE) to demonstrate the expected performance of the disposal system using a probabilistic risk assessment or performance assessment (PA). This PA must show that the expected repository performance will not release radioactive material above limits set by the EPA's standard. This assessment must include the consideration of inadvertent drilling into the repository at some future time.

  13. Delaware Basin Monitoring Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    Washington Regulatory and Environmental Services; Washington TRU Solutions LLC

    2004-09-30

    The Delaware Basin Drilling Surveillance Program (DBDSP) is designed to monitor drilling activities in the vicinity of the Waste Isolation Pilot Plant (WIPP). This program is based on Environmental Protection Agency (EPA) requirements. The EPA environmental standards for the management and disposal of transuranic (TRU) radioactive waste are codified in 40 CFR Part 191 (EPA 1993). Subparts B and C of the standard address the disposal of radioactive waste. The standard requires the Department of Energy (DOE) to demonstrate the expected performance of the disposal system using a probabilistic risk assessment or performance assessment (PA). This PA must show that the expected repository performance will not release radioactive material above limits set by the EPA's standard. This assessment must include the consideration of inadvertent drilling into the repository at some future time.

  14. Deleware Basin Monitoring Annual Report

    International Nuclear Information System (INIS)

    2000-01-01

    The Delaware Basin Drilling Surveillance Program (DBDSP) is designed to monitor drilling activities in the vicinity of the Waste Isolation Pilot Plant (WIPP). This program is based on Environmental Protection Agency (EPA) requirements. The EPA environmental standards for the management and disposal of transuranic (TRU) radioactive waste are codified in 40 CFR Part 191 (EPA 1993). Subparts B and C of the standard address the disposal of radioactive waste. The standard requires the Department of Energy (DOE) to demonstrate the expected performance of the disposal system using a probabilistic risk assessment or performance assessment (PA). This PA must show that the expected repository performance will not release radioactive material above limits set by the EPA's standard. This assessment must include the consideration of inadvertent drilling into the repository at some future time.

  15. Delaware Basin Monitoring Annual Report

    International Nuclear Information System (INIS)

    2005-01-01

    The Delaware Basin Drilling Surveillance Program (DBDSP) is designed to monitor drilling activities in the vicinity of the Waste Isolation Pilot Plant (WIPP). This program is based on Environmental Protection Agency (EPA) requirements. The EPA environmental standards for the management and disposal of transuranic (TRU) radioactive waste are codified in 40 CFR Part 191 (EPA 1993). Subparts B and C of the standard address the disposal of radioactive waste. The standard requires the Department of Energy (DOE) to demonstrate the expected performance of the disposal system using a probabilistic risk assessment or performance assessment (PA). This PA must show that the expected repository performance will not release radioactive material above limits set by the EPA's standard. This assessment must include the consideration of inadvertent drilling into the repository at some future time.

  16. Delaware Basin Monitoring Annual Report

    International Nuclear Information System (INIS)

    2002-01-01

    The Delaware Basin Drilling Surveillance Program (DBDSP) is designed to monitor drilling activities in the vicinity of the Waste Isolation Pilot Plant (WIPP). This program is based on Environmental Protection Agency (EPA) requirements. The EPA environmental standards for the management and disposal of transuranic (TRU) radioactive waste are codified in 40 CFR Part 191 (EPA 1993). Subparts B and C of the standard address the disposal of radioactive waste. The standard requires the Department of Energy (DOE) to demonstrate the expected performance of the disposal system using a probabilistic risk assessment or performance assessment (PA). This PA must show that the expected repository performance will not release radioactive material above limits set by the EPA's standard. This assessment must include the consideration of inadvertent drilling into the repository at some future time.

  17. Delaware Basin Monitoring Annual Report

    International Nuclear Information System (INIS)

    2004-01-01

    The Delaware Basin Drilling Surveillance Program (DBDSP) is designed to monitor drilling activities in the vicinity of the Waste Isolation Pilot Plant (WIPP). This program is based on Environmental Protection Agency (EPA) requirements. The EPA environmental standards for the management and disposal of transuranic (TRU) radioactive waste are codified in 40 CFR Part 191 (EPA 1993). Subparts B and C of the standard address the disposal of radioactive waste. The standard requires the Department of Energy (DOE) to demonstrate the expected performance of the disposal system using a probabilistic risk assessment or performance assessment (PA). This PA must show that the expected repository performance will not release radioactive material above limits set by the EPA's standard. This assessment must include the consideration of inadvertent drilling into the repository at some future time.

  18. Delaware Basin Monitoring Annual Report

    International Nuclear Information System (INIS)

    2003-01-01

    The Delaware Basin Drilling Surveillance Program (DBDSP) is designed to monitor drilling activities in the vicinity of the Waste Isolation Pilot Plant (WIPP). This program is based on Environmental Protection Agency (EPA) requirements. The EPA environmental standards for the management and disposal of transuranic (TRU) radioactive waste are codified in 40 CFR Part 191 (EPA 1993). Subparts B and C of the standard address the disposal of radioactive waste. The standard requires the Department of Energy (DOE) to demonstrate the expected performance of the disposal system using a probabilistic risk assessment or performance assessment (PA). This PA must show that the expected repository performance will not release radioactive material above limits set by the EPA's standard. This assessment must include the consideration of inadvertent drilling into the repository at some future time.

  19. East Asia basin Analysis Project

    International Nuclear Information System (INIS)

    Terman, M.J.

    1986-01-01

    The United Nations-related Committee for Coordination of Joint Prospecting for Mineral Resources in Asian Offshore Areas (CCOP), in cooperation with the International Union of Geological Sciences and Circum-Pacific Council, is implementing the East Asia Basin Analysis Project. National and regional organizations, principally members of the ASEAN Council of Petroleum, are compiling maps at a scale of 1:2 million and stratigraphic cross sections of basins, with particular initial emphasis on defining and assessing oil and gas plays and with later analytical focus on other sedimentary minerals (e.g., coal, phosphate, evaporites, and uranium). Completion is anticipated in 1988. Two major elements of the project are being contributed from other agencies. (1) Base maps. - The US Geological Survey (USGS) has partly compiled eight sheets covering east Asia that show bathymetry, shorelines, and drainage systems. One sheet also presents topography and selected cultural features. All sheets are scheduled to be completed in 1987. (2) Geotectonic maps. - The Working Group on Studies of East Asian Tectonics and Resources (SEATAR) is now completing 10 transect studies with crustal profiles and strip maps at a scale of 1:1 million. One map for each transect shows a plate tectonic interpretation. Transect coordinators or others will be encouraged to extrapolate between the strips and complete the geotectonic interpretation (on USGS bases) in 1987. The IGCP Project 220 is also compiling on (USGS bases) the tin and tungsten granites of east Asia, emphasizing geochemical data needed to identify predictive models. Other mapping will probably follow mineral-deposit modeling workshops on ophiolotic chromite and regional symposia on oceanic massive sulfide and subvolcanic gold and base metals. Completion may be possible by 1989

  20. Evaporitic minibasins of the Sivas Basin (Turkey)

    Science.gov (United States)

    Pichat, Alexandre; Hoareau, Guilhem; Callot, Jean-Paul; Ringenbach, Jean-Claude; Kavak, Kaan

    2017-04-01

    The Oligo-Miocene Sivas basin (Turkey) was strongly affected by salt tectonics, best expressed in its central part. Halokinesis initiated from a main evaporite layer deposited during the Upper Eocene. Such evaporitic accumulations led to two generations of mini basins filled with continental to marine deposits, and nowadays separated by diapiric gypsum walls or welds. Some mini-basins developed above depleting diapirs, filled by more than 50 % of lacustrine to sebkhaic gypsiferous facies. These evaporitic mini-basins (EMB) developed during periods of limited fluvial input, when diapiric stems were outcropping with insignificant topographic reliefs. Chemical analyses (S, O and Sr) suggest that such evaporites were sourced from the recycling of adjacent salt structures. EMB development above diapirs can be explained by (i) high regional accommodation (Ribes et al., 2016), (ii) erosion of the diapiric crests by the fluvial system preceding evaporite deposition, (iii) deflation of some diapirs in a transtensive setting (Kergaravat, 2015), and (iv) fast sedimentation rate of the evaporites. EMB stand out from other siliciclastic mini-basins of the Sivas Basin by (i) their small dimension (sedimentation rate of the evaporites and (iii) the high density of the gypsum and anhydrite compared to halite. The Great Kavir in Iran could display present day analogues relevant of early-stage EMB. Finally, although EMB have never been identified in other ancient halokinetic settings, they may have developed in arid, continental environments such as in the Precaspian Basin.

  1. Submarine landslides in Arctic sedimentation: Canada Basin

    Science.gov (United States)

    Mosher, David C.; Shimeld, John; Hutchinson, Deborah R.; Lebedova-Ivanova, N; Chapman, C.

    2016-01-01

    Canada Basin of the Arctic Ocean is the least studied ocean basin in the World. Marine seismic field programs were conducted over the past 6 years using Canadian and American icebreakers. These expeditions acquired more than 14,000 line-km of multibeam bathymetric and multi-channel seismic reflection data over abyssal plain, continental rise and slope regions of Canada Basin; areas where little or no seismic reflection data existed previously. Canada Basin is a turbidite-filled basin with flat-lying reflections correlateable over 100s of km. For the upper half of the sedimentary succession, evidence of sedimentary processes other than turbidity current deposition is rare. The Canadian Archipelago and Beaufort Sea margins host stacked mass transport deposits from which many of these turbidites appear to derive. The stratigraphic succession of the MacKenzie River fan is dominated by mass transport deposits; one such complex is in excess of 132,000 km2 in area and underlies much of the southern abyssal plain. The modern seafloor is also scarred with escarpments and mass failure deposits; evidence that submarine landsliding is an ongoing process. In its latest phase of development, Canada Basin is geomorphologically confined with stable oceanographic structure, resulting in restricted depositional/reworking processes. The sedimentary record, therefore, underscores the significance of mass-transport processes in providing sediments to oceanic abyssal plains as few other basins are able to do.

  2. The fast trigger electronics of the lead/scintillating fiber calorimeter SpaCal of the H1 experiment at HERA: accomplishment, results of test beam measurements at CERN and first results at HERA

    International Nuclear Information System (INIS)

    Spielmann, Stephan

    1996-01-01

    The studies presented in this thesis cover parts of the project to improve the H1 detector at the electron-proton collider HERA. The main goal of this improvement was to build a lead/scintillating fiber calorimeter (SpaCal) and its associate trigger and read-out electronics. The description and the analysis of measurements with a calorimeter prototype and its electronics are presented with respect to the performance requirements for the project. This measurement realized at a CERN test beam facility have shown that an on-line selection of physics events out of background events can be achieved with a time-of-flight measurement. The efficiency of the trigger is higher than 99 percent independent of the particles' impact points. The feasibility of electron/pion separation on the one percent level is also shown. In 1995 the SpaCal calorimeter was integrated in the H1 detector. A detailed description of its associate electronics is given and the results on the trigger's performance for the first year of data taking are presented. (author) [fr

  3. [The effectiveness of the spa and health resort-based treatment with the application of Essentuki-type drinking mineral waters for the management of non-alcoholic fatty liver disease in the patients presenting with type 2 diabetes mellitus].

    Science.gov (United States)

    Efimenko, N V; Kaĭsinova, A S; Fedorova, T E; Botvineva, L A

    2015-01-01

    The objective of the present study was to estimate the effectiveness of the spa and health resort-based treatment of non-alcoholic fatty liver disease in 40 patients at the mean age of 48,8 ± 5.7 years suffering from type 2 diabetes mellitus. All of them received combined therapy including the application of potable Essentuki-Novaya mineral water (20 patients) or Essentuki No 4 water (20 patients). This therapeutic modality resulted in positive dynamics of clinical symptoms of the disease, the functional liver tests, and parameters of intra-hepatic hemodynamics, lipid peroxidation homeostasis, and the hormonal status. It is concluded that the spa and health resort-based treatment with the application of local drinking Essentuki-type mineral waters for the management of non-alcoholic fatty liver disease in the patients presenting with type 2 diabetes mellitus leads to the improvement of the main functions of the liver, stabilizes carbohydrate and lipid metabolism, and prevents progression of the pathological process.

  4. Damming the rivers of the Amazon basin.

    Science.gov (United States)

    Latrubesse, Edgardo M; Arima, Eugenio Y; Dunne, Thomas; Park, Edward; Baker, Victor R; d'Horta, Fernando M; Wight, Charles; Wittmann, Florian; Zuanon, Jansen; Baker, Paul A; Ribas, Camila C; Norgaard, Richard B; Filizola, Naziano; Ansar, Atif; Flyvbjerg, Bent; Stevaux, Jose C

    2017-06-14

    More than a hundred hydropower dams have already been built in the Amazon basin and numerous proposals for further dam constructions are under consideration. The accumulated negative environmental effects of existing dams and proposed dams, if constructed, will trigger massive hydrophysical and biotic disturbances that will affect the Amazon basin's floodplains, estuary and sediment plume. We introduce a Dam Environmental Vulnerability Index to quantify the current and potential impacts of dams in the basin. The scale of foreseeable environmental degradation indicates the need for collective action among nations and states to avoid cumulative, far-reaching impacts. We suggest institutional innovations to assess and avoid the likely impoverishment of Amazon rivers.

  5. Deep controls on intraplate basin inversion

    DEFF Research Database (Denmark)

    Nielsen, S.B.; Stephenson, Randell Alexander; Schiffer, Christian

    2014-01-01

    favourably orientated with respect to pre-existing structures in the lithosphere. Furthermore, stresses derived from lithospheric potential energy variations as well as those from plate boundary forces must be taken into account in order to explain intraplate seismicity and deformation such as basin......Basin inversion is an intermediate-scale manifestation of continental intraplate deformation, which produces earthquake activity in the interior of continents. The sedimentary basins of central Europe, inverted in the Late Cretaceous– Paleocene, represent a classic example of this phenomenon...

  6. K Basins isolation barriers summary report

    Energy Technology Data Exchange (ETDEWEB)

    Strickland, G.C., Westinghouse Hanford

    1996-07-31

    The 105-K East and 105-K West fuel storage basins (105-K Basins) were designed and constructed in the early 1950`s for interim storage of irradiated fuel following its discharge from the reactors. The 105-K- East and 105-K West reactor buildings were constructed first, and the associated storage basins were added about a year later. The construction joint between each reactor building structure and the basin structure included a flexible membrane waterstop to prevent leakage. Water in the storage basins provided both radiation shielding and cooling to remove decay heat from stored fuel until its transfer to the Plutonium Uranium Extraction (PUREX) Facility for chemical processing. The 105-K West Reactor was permanently shut down in February 1970; the 105-K East Reactor was permanently shut down in February 1971. Except for a few loose pieces, fuel stored in the basins at that time was shipped to the PUREX Facility for processing. The basins were then left idle but were kept filled with water. The PUREX Facility was shut down and placed on wet standby in 1972 while N Reactor continued to operate. When the N Reactor fuel storage basin began to approach storage capacity, the decision was made to modify the fuel storage basins at 105-K East and 105-K West to provide additional storage capacity. Both basins were subsequently modified (105-K East in 1975 and 105-K West in 1981) to provide for the interim handling and storage of irradiated N Reactor fuel. The PUREX Facility was restarted in November 1983 to provide 1698 additional weapons-grade plutonium for the United States defense mission. The facility was shut down and deactivated in December 1992 when the U.S. Department of Energy (DOE) determined that the plant was no longer needed to support weapons-grade plutonium production. When the PUREX Facility was shut down, approximately 2.1 x 1 06 kg (2,100 metric tons) of irradiated fuel aged 7 to 23 years was left in storage in the 105-K Basins pending a decision on

  7. Western Gas Sands Project. Quarterly Basin Activities Report

    Energy Technology Data Exchange (ETDEWEB)

    Atkinson, C H

    1979-01-31

    This report is a summation of 3 months' drilling and testing activities in the four primary WGSP study areas: Greater Green River Basin, Northern Great Plains Province, Piceance Basin, and Uinta Basin. The monitoring of basin activities is part of resource assessment. (DLC)

  8. Gravity and geothermal anomalies in Borno Basin, Nigeria ...

    African Journals Online (AJOL)

    Some prominent geothermal anomalies are found occurring in association with gravity anomalies in the Borno basin. Similar gravity anomalies also occur in the Benue and Niger (Nupe) basins. Both the geothermal and gravity anomalies of Borno basin are trending NW-SE similar to the Niger (Nupe) basin, while the Benue ...

  9. Prediction method of sediment discharge from forested basin

    Science.gov (United States)

    Kazutoki Abe; Ushio Kurokawa; Robert R. Ziemer

    2000-01-01

    An estimation model for sediment discharge from a forested basin using Universal Soil Loss Equation and delivery ratio was developed. Study basins are North fork and South fork in Caspar Creek, north California, where Forest Service, USDA has been using water and sediment discharge from both basins since 1962. The whole basin is covered with the forest, mainly...

  10. Synchronization and basin bifurcations in mutually coupled oscillators

    Indian Academy of Sciences (India)

    ... basin bifurcation sequences occur leading to + 1, ≥ 2 basins as the coupling is varied – a signature of Wada structure and final-state sensitivity. However, in the region of complete synchronization, the basins structure is identical with that of the single oscillators and retains its essential features including fractal basin ...

  11. K-Basins S/RIDS

    Energy Technology Data Exchange (ETDEWEB)

    Watson, D.J.

    1997-08-01

    The Standards/Requirements Identification Document (S/RID) is a list of the Environmental, Safety, and Health (ES{ampersand}H) and Safeguards and Security (SAS) standards/requirements applicable to the K Basins facility.

  12. VT Lakes and Ponds Drainage Basins

    Data.gov (United States)

    Vermont Center for Geographic Information — (Link to Metadata) The WaterHydro_LKBSPRE layer consists of drainage basins for water bodies of approximately five or more acres. The data was digitized from...

  13. K-Basins S/RIDS

    International Nuclear Information System (INIS)

    Watson, D.J.

    1997-01-01

    The Standards/Requirements Identification Document (S/RID) is a list of the Environmental, Safety, and Health (ES(ampersand)H) and Safeguards and Security (SAS) standards/requirements applicable to the K Basins facility

  14. K-Basins S/RIDS

    Energy Technology Data Exchange (ETDEWEB)

    Watson, D.J.

    1995-09-22

    The Standards/Requirements Identification Document(S/RID) is a list of the Environmental, Safety, and Health (ES&H) and Safeguards and Security (SAS) standards/requirements applicable to the K Basins facility

  15. 183-H Basin sludge treatability test report

    International Nuclear Information System (INIS)

    Biyani, R.K.

    1995-01-01

    This document presents the results from the treatability testing of a 1-kg sample of 183-H Basin sludge. Compressive strength measurements, Toxic Characteristic Leach Procedure, and a modified ANSI 16.1 leach test were conducted

  16. Pumices from the Central Indian Ocean Basin

    Digital Repository Service at National Institute of Oceanography (India)

    Iyer, S.D.

    sediments are significant not only volumetrically but also as indicators of tectonic environments. A few studies in the past concerning the volcanogenic components in the Indian Ocean are informative but these do not pertain to the Central Indian Ocean Basin...

  17. KE Basin water dispositioning engineering study

    International Nuclear Information System (INIS)

    Hunacek, G.S.; Gahir, S.S.

    1994-01-01

    This engineering study is a feasibility study of KE Basin water treatment to an acceptable level and dispositioning the treated water to Columbia River, ground through ETF or to air through evaporation

  18. Climate change and the Great Basin

    Science.gov (United States)

    Jeanne C. Chambers

    2008-01-01

    Climate change is expected to have significant impacts on the Great Basin by the mid-21st century. The following provides an overview of past and projected climate change for the globe and for the region.

  19. Program Updates - San Antonio River Basin

    Science.gov (United States)

    This page will house updates for this urban waters partnership location. As projects progress, status updates can be posted here to reflect the ongoing work by partners in San Antonio working on the San Antonio River Basin.

  20. River Basin Standards Interoperability Pilot

    Science.gov (United States)

    Pesquer, Lluís; Masó, Joan; Stasch, Christoph

    2016-04-01

    There is a lot of water information and tools in Europe to be applied in the river basin management but fragmentation and a lack of coordination between countries still exists. The European Commission and the member states have financed several research and innovation projects in support of the Water Framework Directive. Only a few of them are using the recently emerging hydrological standards, such as the OGC WaterML 2.0. WaterInnEU is a Horizon 2020 project focused on creating a marketplace to enhance the exploitation of EU funded ICT models, tools, protocols and policy briefs related to water and to establish suitable conditions for new market opportunities based on these offerings. One of WaterInnEU's main goals is to assess the level of standardization and interoperability of these outcomes as a mechanism to integrate ICT-based tools, incorporate open data platforms and generate a palette of interchangeable components that are able to use the water data emerging from the recently proposed open data sharing processes and data models stimulated by initiatives such as the INSPIRE directive. As part of the standardization and interoperability activities in the project, the authors are designing an experiment (RIBASE, the present work) to demonstrate how current ICT-based tools and water data can work in combination with geospatial web services in the Scheldt river basin. The main structure of this experiment, that is the core of the present work, is composed by the following steps: - Extraction of information from river gauges data in OGC WaterML 2.0 format using SOS services (preferably compliant to the OGC SOS 2.0 Hydrology Profile Best Practice). - Model floods using a WPS 2.0, WaterML 2.0 data and weather forecast models as input. - Evaluation of the applicability of Sensor Notification Services in water emergencies. - Open distribution of the input and output data as OGC web services WaterML, / WCS / WFS and with visualization utilities: WMS. The architecture

  1. Geo-economy of the Caspian basin

    International Nuclear Information System (INIS)

    Raballand, G.

    2003-05-01

    The Caspian area is essential for the development of the central Asia countries and Caucasus. Excepted the Iran and the Russia, these areas economy is poor. The hydrocarbons exploitation should reinforce the economic weight of these States. The author analyzes the Caspian area economies and shows that the basin economies are confronted with three handicaps, and that even with different economic ways, the soviet economic system is still present in the basin. (A.L.B.)

  2. Are calanco landforms similar to river basins?

    Science.gov (United States)

    Caraballo-Arias, N A; Ferro, V

    2017-12-15

    In the past badlands have been often considered as ideal field laboratories for studying landscape evolution because of their geometrical similarity to larger fluvial systems. For a given hydrological process, no scientific proof exists that badlands can be considered a model of river basin prototypes. In this paper the measurements carried out on 45 Sicilian calanchi, a type of badlands that appears as a small-scale hydrographic unit, are used to establish their morphological similarity with river systems whose data are available in the literature. At first the geomorphological similarity is studied by identifying the dimensionless groups, which can assume the same value or a scaled one in a fixed ratio, representing drainage basin shape, stream network and relief properties. Then, for each property, the dimensionless groups are calculated for the investigated calanchi and the river basins and their corresponding scale ratio is evaluated. The applicability of Hack's, Horton's and Melton's laws for establishing similarity criteria is also tested. The developed analysis allows to conclude that a quantitative morphological similarity between calanco landforms and river basins can be established using commonly applied dimensionless groups. In particular, the analysis showed that i) calanchi and river basins have a geometrically similar shape respect to the parameters Rf and Re with a scale factor close to 1, ii) calanchi and river basins are similar respect to the bifurcation and length ratios (λ=1), iii) for the investigated calanchi the Melton number assumes values less than that (0.694) corresponding to the river case and a scale ratio ranging from 0.52 and 0.78 can be used, iv) calanchi and river basins have similar mean relief ratio values (λ=1.13) and v) calanchi present active geomorphic processes and therefore fall in a more juvenile stage with respect to river basins. Copyright © 2017 Elsevier B.V. All rights reserved.

  3. Water scarcity in the Jordan River basin.

    Science.gov (United States)

    Civic, M A

    1999-03-01

    This article reports the problem on water scarcity in the Jordan River basin. In the Jordan River basin, freshwater scarcity results from multiple factors and most severely affects Israel, Jordan, the West Bank, and the Gaza Strip. One of these multiple factors is the duration of rainfall in the region that only occurs in a small area of highlands in the northwest section. The varying method of water use parallels that of Israel that utilizes an estimated 2000 million cu. m. The national patterns of water usage and politically charged territorial assertions compound the competition over freshwater resources in the region. The combination of political strife, resource overuse, and contaminated sources means that freshwater scarcity in the Jordan River basin will reach a critical level in the near future. History revealed that the misallocation/mismanagement of freshwater from the Jordan River basin was the result of centuries of distinct local cultural and religious practices combined with historical influences. Each state occupying near the river basin form their respective national water development schemes. It was not until the mid-1990s that a shared-use approach was considered. Therefore, the critical nature of water resource, the ever-dwindling supply of freshwater in the Jordan River basin, and the irrevocability of inappropriate policy measures requires unified, definitive, and ecologically sound changes to the existing policies and practices to insure an adequate water supply for all people in the region.

  4. Estimating tectonic history through basin simulation-enhanced seismic inversion: Geoinformatics for sedimentary basins

    Science.gov (United States)

    Tandon, K.; Tuncay, K.; Hubbard, K.; Comer, J.; Ortoleva, P.

    2004-01-01

    A data assimilation approach is demonstrated whereby seismic inversion is both automated and enhanced using a comprehensive numerical sedimentary basin simulator to study the physics and chemistry of sedimentary basin processes in response to geothermal gradient in much greater detail than previously attempted. The approach not only reduces costs by integrating the basin analysis and seismic inversion activities to understand the sedimentary basin evolution with respect to geodynamic parameters-but the technique also has the potential for serving as a geoinfomatics platform for understanding various physical and chemical processes operating at different scales within a sedimentary basin. Tectonic history has a first-order effect on the physical and chemical processes that govern the evolution of sedimentary basins. We demonstrate how such tectonic parameters may be estimated by minimizing the difference between observed seismic reflection data and synthetic ones constructed from the output of a reaction, transport, mechanical (RTM) basin model. We demonstrate the method by reconstructing the geothermal gradient. As thermal history strongly affects the rate of RTM processes operating in a sedimentary basin, variations in geothermal gradient history alter the present-day fluid pressure, effective stress, porosity, fracture statistics and hydrocarbon distribution. All these properties, in turn, affect the mechanical wave velocity and sediment density profiles for a sedimentary basin. The present-day state of the sedimentary basin is imaged by reflection seismology data to a high degree of resolution, but it does not give any indication of the processes that contributed to the evolution of the basin or causes for heterogeneities within the basin that are being imaged. Using texture and fluid properties predicted by our Basin RTM simulator, we generate synthetic seismograms. Linear correlation using power spectra as an error measure and an efficient quadratic

  5. Wyoming Basin Rapid Ecoregional Assessment

    Science.gov (United States)

    Carr, Natasha B.; Melcher, Cynthia P.

    2015-08-28

    The Wyoming Basin Rapid Ecoregional Assessment was conducted in partnership with the Bureau of Land Management (BLM). The overall goals of the BLM Rapid Ecoregional Assessments (REAs) are to identify important ecosystems and wildlife habitats at broad spatial scales; identify where these resources are at risk from Change Agents, including development, wildfire, invasive species, disease and climate change; quantify cumulative effects of anthropogenic stressors; and assess current levels of risk to ecological resources across a range of spatial scales and jurisdictional boundaries by assessing all lands within an ecoregion. There are several components of the REAs. Management Questions, developed by the BLM and stakeholders for the ecoregion, identify the regionally significant information needed for addressing land-management responsibilities. Conservation Elements represent regionally significant species and ecological communities that are of management concern. Change Agents that currently affect or are likely to affect the condition of species and communities in the future are identified and assessed. REAs also identify areas that have high conservation potential that are referred to as “large intact areas.” At the ecoregion level, the ecological value of large intact areas is based on the assumption that because these areas have not been greatly altered by human activities (such as development), they are more likely to contain a variety of plant and animal communities and to be resilient and resistant to changes resulting from natural disturbances such as fire, insect outbreaks, and disease.

  6. Evaluation of the efficacy of a short-course, personalized self-management and intensive spa therapy intervention as active prevention of musculoskeletal disorders of the upper extremities (Muska): a research protocol for a randomized controlled trial.

    Science.gov (United States)

    Lanhers, Charlotte; Pereira, Bruno; Gay, Chloé; Hérisson, Christian; Levyckyj, Christine; Dupeyron, Arnaud; Coudeyre, Emmanuel

    2016-12-09

    Musculoskeletal disorders (MSDs) constitute a major occupational health problem in the working population, substantially impacting the quality of life of employees. They also cause considerable economic cost to the healthcare system, with, notably, the reimbursement of treatments and compensation for lost income. MSDs manifest as localized pain or functional difficulty in one or more anatomical areas, such as the cervical spine, shoulder, elbow, hand, and wrist. Although prevalence varies depending on the region considered and the method of assessment, a prevalence of 30% is found in different epidemiological studies. The disease needs to be prevented, not only for medical and economic reasons, but also for legal reasons, owing to the requirement of assessing occupational risks. The strategy envisaged may thus revolve around active, multimodal prevention that has employees fully involved at the heart of their care. Although physical exercise is widely recommended, few studies with a good level of evidence have enabled us to base a complete, well-constructed intervention on exercise that can be offered as secondary prevention in these disorders. A prospective, multicenter, comparative (intervention arm vs. control arm), randomized (immediate vs. later treatment) study using Zelen's design. This study falls under active prevention of MSDs of the upper extremities (UE-MSDs). Participants are workers aged between 18 and 65 years with latent or symptomatic MSDS, with any type of job or workstation, with or without an history of sick leave. The primary aim is to show the superiority at 3 months of a combination of spa therapy, exercise, and self-management workshops for 6 days over usual care in the management of MSDs in terms of employee functional capacity in personal and professional daily life. Secondary aims are to assess the benefit of the intervention in terms of pain, quality of life, and accumulated duration of sick leave. This randomized controlled trial is

  7. Petroleum systems in rift basins – a collective approach in South-east Asian basins.

    NARCIS (Netherlands)

    Doust, H.; Sumner, D.

    2007-01-01

    This paper synthesizes some of the main conclusions reached in a recent regional review of the Tertiary basins of Southeast Asia, carried out by Shell. Four distinctive types of petroleum systems, correlating with the four main stages of basin evolution (early to late syn-rift and early to late

  8. Implication of drainage basin parameters of a tropical river basin of South India

    Science.gov (United States)

    Babu, K. J.; Sreekumar, S.; Aslam, Arish

    2016-03-01

    Drainage morphometry provides quantitative description of the drainage system which is an important aspect of the characterisation of watersheds. Chalakudi River is one of the important rivers of the South India which has attracted attention of many environmental scientists recently because of the proposed Athirapally Hydel Project across the river. SRTM (Shuttle Radar Topographic Mission) data were used for preparing DEM (Digital Elevation Model), Aspect Map and Slope Map. Geographical Information System (GIS) was used for the evaluation of linear, areal and relief aspects of morphometric parameters. The study reveals that the terrain exhibits dentritic and trellis pattern of drainage. The Chalakudi River Basin has a total area of 1,448.73 km2 and is designated as seventh-order basin. The drainage density of the basin is estimated as 2.54 and the lower-order streams mostly dominate the basin. The high basin relief indicates high runoff and sediment transport. The elongation ratio of the Chalakudi Basin is estimated as 0.48 and indicates that the shape of the basin is elongated. The development of stream segments in the basin area is more or less effected by rainfall. Relief ratio indicates that the discharge capability of watershed is very high and the groundwater potential is meagre. The low value of drainage density in spite of mountainous relief indicates that the area is covered by dense vegetation and resistant rocks permeated by fractures and joints. These studies are helpful in watershed development planning and wise utilization of natural resources.

  9. The long wavelength topography of Beethoven and Tolstoj basins, Mercury

    Science.gov (United States)

    André, Sarah L.; Watters, Thomas R.; Robinson, Mark S.

    2005-11-01

    Topography derived from Mariner 10 stereo images is used to characterize the interior structure of two mercurian basins, Beethoven and Tolstoj. Beethoven and Tolstoj basins are shallow (~2.5 km and ~2 km deep, respectively) and relatively flat-floored. Beethoven basin has an interior topographic rise near the northwest margin. The topography of Beethoven and Tolstoj basins is similar to that of lunar mare-filled basins. Well-developed basin-concentric wrinkle ridges and arcuate graben associated with lunar mascons are absent in both Beethoven and Tolstoj basins. The lack of mascon tectonic features suggests that either 1) the mercurian basins have a relatively thin veneer of fill material, 2) Mercury's elastic lithosphere was too strong for significant lithospheric flexure and subsidence to occur, or 3) the basin fill material has little or no density contrast with the surrounding crust and thus exerts little net load on the mercurian lithosphere.

  10. 18 January 2011 - Ing. Vittorio Malacalza, ASG Superconductors S.p.A, Italy in the LHC superconducting magnet test hall with Deputy Department Head L. Rossi, in the LHC tunnel at Point 5 and CMS experimental area with Spokesperson G. Tonelli.

    CERN Multimedia

    Maximilien Brice

    2011-01-01

    18 January 2011 - Ing. Vittorio Malacalza, ASG Superconductors S.p.A, Italy in the LHC superconducting magnet test hall with Deputy Department Head L. Rossi, in the LHC tunnel at Point 5 and CMS experimental area with Spokesperson G. Tonelli.

  11. Petroleum geology of the Palo Duro Basin, Texas Panhandle

    International Nuclear Information System (INIS)

    Rose, P.R.

    1986-03-01

    The Palo Duro Basin, Permian Basin, Texas is an asymmetric, relatively shallow, intracratonic basin in the southern Texas Panhandle filled mostly by Mississippian, Pennsylvanian, and Permian sedimentary rocks. Although deeper and prolific prolific petroleum-producing basins adjoin it on the north (Anadarko Basin), south (Midland Basin), and east (Hardeman Basin), the Palo Duro Basin has produced remarkably small amounts of oil and gas to date. This is all the more noteworthy because the sedimentary sequence and rock types of the basin are similar to those of the adjacent basins. Analyses of the stratigraphic succession and structural configuration of the Palo Duro Basin suggest that adequate reservoir rocks, top-seals, and geologic structures are present. Most of the structures formed early enough to have trapped hydrocarbons if they were migrating in the rock column. Although additional work is under way to properly address the question of the petroleum source rocks, generation, and migration, the general absence of production in the basin may relate to an overall deficiency in hydrocarbon generation within the basin. Geologic information in this report will form part of the basis for further analysis and conclusions on hydrocarbon potential in the Palo Duro Basin

  12. Evapotranspiration seasonality across the Amazon Basin

    Directory of Open Access Journals (Sweden)

    E. E. Maeda

    2017-06-01

    Full Text Available Evapotranspiration (ET of Amazon forests is a main driver of regional climate patterns and an important indicator of ecosystem functioning. Despite its importance, the seasonal variability of ET over Amazon forests, and its relationship with environmental drivers, is still poorly understood. In this study, we carry out a water balance approach to analyse seasonal patterns in ET and their relationships with water and energy drivers over five sub-basins across the Amazon Basin. We used in situ measurements of river discharge, and remotely sensed estimates of terrestrial water storage, rainfall, and solar radiation. We show that the characteristics of ET seasonality in all sub-basins differ in timing and magnitude. The highest mean annual ET was found in the northern Rio Negro basin (∼ 1497 mm year−1 and the lowest values in the Solimões River basin (∼ 986 mm year−1. For the first time in a basin-scale study, using observational data, we show that factors limiting ET vary across climatic gradients in the Amazon, confirming local-scale eddy covariance studies. Both annual mean and seasonality in ET are driven by a combination of energy and water availability, as neither rainfall nor radiation alone could explain patterns in ET. In southern basins, despite seasonal rainfall deficits, deep root water uptake allows increasing rates of ET during the dry season, when radiation is usually higher than in the wet season. We demonstrate contrasting ET seasonality with satellite greenness across Amazon forests, with strong asynchronous relationships in ever-wet watersheds, and positive correlations observed in seasonally dry watersheds. Finally, we compared our results with estimates obtained by two ET models, and we conclude that neither of the two tested models could provide a consistent representation of ET seasonal patterns across the Amazon.

  13. Rifting Thick Lithosphere - Canning Basin, Western Australia

    Science.gov (United States)

    Czarnota, Karol; White, Nicky

    2016-04-01

    The subsidence histories and architecture of most, but not all, rift basins are elegantly explained by extension of ~120 km thick lithosphere followed by thermal re-thickening of the lithospheric mantle to its pre-rift thickness. Although this well-established model underpins most basin analysis, it is unclear whether the model explains the subsidence of rift basins developed over substantially thick lithosphere (as imaged by seismic tomography beneath substantial portions of the continents). The Canning Basin of Western Australia is an example where a rift basin putatively overlies lithosphere ≥180 km thick, imaged using shear wave tomography. Subsidence modelling in this study shows that the entire subsidence history of the account for the observed subsidence, at standard crustal densities, the lithospheric mantle is required to be depleted in density by 50-70 kg m-3, which is in line with estimates derived from modelling rare-earth element concentrations of the ~20 Ma lamproites and global isostatic considerations. Together, these results suggest that thick lithosphere thinned to > 120 km is thermally stable and is not accompanied by post-rift thermal subsidence driven by thermal re-thickening of the lithospheric mantle. Our results show that variations in lithospheric thickness place a fundamental control on basin architecture. The discrepancy between estimates of lithospheric thickness derived from subsidence data for the western Canning Basin and those derived from shear wave tomography suggests that the latter technique currently is limited in its ability to resolve lithospheric thickness variations at horizontal half-wavelength scales of <300 km.

  14. Desert basins of the Southwest

    Science.gov (United States)

    Leake, Stanley A.; Konieczki, Alice D.; Rees, Julie A.H.

    2000-01-01

    Ground water is among the Nation’s most important natural resources. It provides drinking water to urban and rural communities, supports irrigation and industry, sustains the flow of streams and rivers, and maintains riparian and wetland ecosystems. In many areas of the Nation, the future sustainability of ground-water resources is at risk from overuse and contamination. Because ground-water systems typically respond slowly to human actions, a long-term perspective is needed to manage this valuable resource. This publication is one in a series of fact sheets that describe ground-water-resource issues across the United States, as well as some of the activities of the U.S. Geological Survey that provide information to help others develop, manage, and protect ground-water resources in a sustainable manner. Ground-water resources in the Southwest are among the most overused in the United States. Natural recharge to aquifers is low and pumping in many areas has resulted in lowering of water tables. The consequences of large-scale removal of water from storage are becoming increasingly evident. These consequences include land subsidence; loss of springs, streams, wetlands and associated habitat; and degradation of water quality. Water managers are now seeking better ways of managing ground-water resources while looking for supplemental sources of water. This fact sheet reviews basic information on ground water in the desert basins of the Southwest. Also described are some activities of the U.S. Geological Survey (USGS) that are providing scientific information for sustainable management of ground-water resources in the Southwest. Ground-water sustainability is defined as developing and using ground water in a way that can be maintained for an indefinite time without causing unacceptable environmental, economic, or social consequences.

  15. Estudo do comportamento do revestimento de pavimento utilizando mistura asfáltica morna com adição de borracha moída de pneu na SPA-248/055

    Directory of Open Access Journals (Sweden)

    Cecilia Fortes Merighi

    2017-12-01

    Full Text Available This paper presents a study of a warm asphalt mix using rubberized binder additive with surfactant. Tests were made to verify the mechanical behavior of the warm mixture and then compared to a reference rubberized hot mixture. The warm asphalt mix presented satisfactory results. Also, it was made an analysis of reducing pollutant emissions during the mix production. A test section was performed with the warm mixture, located in SPA-248/055, West Lane and compared to the hot mix reference section, located on the same highway. The results indicated that there is a reduction of pollutants such as total smoke, fumes soluble and volatile organic compounds (VOCs. Both the experimental and the reference section were evaluated during 4 years for pavement performance parameters. The results showed a positive behavior of warm asphalt mix compared to the reference pavement section.

  16. Groundwater quality in the Northern Coast Ranges Basins, California

    Science.gov (United States)

    Mathany, Timothy M.; Belitz, Kenneth

    2015-01-01

    The Northern Coast Ranges (NOCO) study unit is 633 square miles and consists of 35 groundwater basins and subbasins (California Department of Water Resources, 2003; Mathany and Belitz, 2015). These basins and subbasins were grouped into two study areas based primarily on locality. The groundwater basins and subbasins located inland, not adjacent to the Pacific Ocean, were aggregated into the Interior Basins (NOCO-IN) study area. The groundwater basins and subbasins adjacent to the Pacific Ocean were aggregated into the Coastal Basins (NOCO-CO) study area (Mathany and others, 2011).

  17. Tectonostratigraphic evolution of the Williston Basin

    Science.gov (United States)

    Redly, Pal

    In the Williston Basin five regional seismic profiles, covering ˜3090 km were utilized for a comprehensive study of this complex geologic feature. 2300 km field data were added to the existing 790 km profile. The novel seismic information in conjunction with a sizeable number of wireline data and incorporation of structural and isopach maps provided a unique data environment for development of a new elaborate tectonostratigraphic model of this major continental depression. Standard reflection seismic processing procedures were implemented with special emphasis on regional perspectives, including "Earth curvature correction", to generate images of the basin fill. The latter helped to reveal the true nature of this large scale cratonic basin. This novel information permitted new approaches in establishing the deformation styles in the Williston Basin. Structural studies of the newly reprocessed regional seismic profiles revealed the compressional nature of the radially arranged tectonic elements in the center of the basin, and the extensional character of the peripheral regions. The results suggest that axisymmetric deformation controlled the early stages of the Williston Basin area, and was the causal factor of the oval shape of the basin. In the first, "pre-Williston" phase, the region was uplifted by an axisymmetric lithospheric intrusion creating radial extensional signatures in the central zone and compressional structures in the surroundings. Erosion and thermal cooling and/or phase change of the mantle material led to the initiation of the basin subsidence. Consequently, in the "intracratonic phase" (Sauk - Absaroka), the pre-existing radial and circumferentially arranged structures were periodically reactivated in the opposite sense. The active periods were unrelated to global orogenic events of the continent. The exception is the Kaskaskia I (Devonian) interval, when the territory was tilted to the northwest and the axisymmetric cause of the subsidence was

  18. Methicillin-resistant Staphylococcus aureus isolates with SCCmec type V and spa types t437 or t1081 associated to discordant susceptibility results between oxacillin and cefoxitin, Central Taiwan.

    Science.gov (United States)

    Ho, Cheng-Mao; Lin, Chien-Yu; Ho, Mao-Wang; Lin, Hsiao-Chuan; Chen, Chao-Jung; Lin, Lee-Chung; Lu, Jang-Jih

    2016-12-01

    Staphylococcus aureus isolates with discordant susceptibility results between oxacillin and cefoxitin obtained using automated microbiology systems are infrequently observed. From April 2013 to December 2014, 1956 methicillin-resistant S. aureus (MRSA) and 1761 methicillin-susceptible S. aureus isolates were obtained from different patients. Forty isolates (1.1% and 2% in case of S. aureus and MRSA, respectively) with discordant susceptibility results (oxacillin susceptible and cefoxitin resistant) and carrying mecA gene were obtained. Except 2 SCCmec type IV isolates, 38 MRSA isolates were all SCCmec type V (V T or non-V T ), which were further divided into V T (n=22) and non-V T (n=16). The most common spa type in V T and non-V T isolates were t437 (n=19) and t1081 (n=13), respectively. Only 55% of patients received effective antimicrobial agents; 2 mortalities were not attributable to MRSA infection. Using standard agar dilution, 17 MRSA isolates (0.46% and 0.87% in case of S. aureus and MRSA, respectively) had oxacillin MIC in the susceptible ranges (oxacillin-susceptible MRSA [OS-MRSA]); all carried SCCmec type V (V T , n=8; non-V T , n=9). The most common spa-MLST types of OS-MRSA in V T and non-V T were t437-ST59 (n=4) and t1081-ST45 (n=7), respectively. Concomitant testing by both cefoxitin- and oxacillin-based methods is a practical strategy for OS-MRSA detection in the clinical laboratories. Continuous monitoring of OS-MRSA isolates is necessary to elucidate their impact in clinical infectious diseases. Copyright © 2016 Elsevier Inc. All rights reserved.

  19. Hydrographic Basins Analysis Using Digital Terrain Modelling

    Science.gov (United States)

    Mihaela, Pişleagă; -Minda Codruţa, Bădăluţă; Gabriel, Eleş; Daniela, Popescu

    2017-10-01

    The paper, emphasis the link between digital terrain modelling and studies of hydrographic basins, concerning the hydrological processes analysis. Given the evolution of computing techniques but also of the software digital terrain modelling made its presence felt increasingly, and established itself as a basic concept in many areas, due to many advantages. At present, most digital terrain modelling is derived from three alternative sources such as ground surveys, photogrammetric data capture or from digitized cartographic sources. A wide range of features may be extracted from digital terrain models, such as surface, specific points and landmarks, linear features but also areal futures like drainage basins, hills or hydrological basins. The paper highlights how the use appropriate software for the preparation of a digital terrain model, a model which is subsequently used to study hydrographic basins according to various geomorphological parameters. As a final goal, it shows the link between digital terrain modelling and hydrographic basins study that can be used to optimize the correlation between digital model terrain and hydrological processes in order to obtain results as close to the real field processes.

  20. Shallow basins on Mercury: Evidence of relaxation?

    Science.gov (United States)

    Mohit, P. Surdas; Johnson, Catherine L.; Barnouin-Jha, Olivier; Zuber, Maria T.; Solomon, Sean C.

    2009-08-01

    Stereo-derived topographic models have shown that the impact basins Beethoven and Tolstoj on Mercury are shallow for their size, with depths of 2.5 and 2 (± 0.7) km, respectively, while Caloris basin has been estimated to be 9 (± 3) km deep on the basis of photoclinometric measurements. We evaluate the depths of Beethoven and Tolstoj in the context of comparable basins on other planets and smaller craters on Mercury, using data from Mariner 10 and the first flyby of the MESSENGER spacecraft. We consider three scenarios that might explain the anomalous depths of these basins: (1) volcanic infilling, (2) complete crustal excavation, and (3) viscoelastic relaxation. None of these can be ruled out, but the fill scenario would imply a thick lithosphere early in Mercury's history and the crustal-excavation scenario a pre-impact crustal thickness of 15-55 km, depending on the density of the crust, in the area of Beethoven and Tolstoj. The potential for viscous relaxation of Beethoven, Tolstoj, and Caloris is explored with a viscoelastic model. Results show that relaxation of these basins could occur at plausible heat flux values for a range of crustal thicknesses. However, the amplitude of current topographic relief points to a crustal thickness of at least 60 km under this hypothesis. Relaxation of Caloris may have occurred if the floor is underlain by crust at least 20 km thick. We discuss future observations by MESSENGER that should distinguish among these scenarios.

  1. Protein structure prediction using basin-hopping

    Science.gov (United States)

    Prentiss, Michael C.; Wales, David J.; Wolynes, Peter G.

    2008-06-01

    Associative memory Hamiltonian structure prediction potentials are not overly rugged, thereby suggesting their landscapes are like those of actual proteins. In the present contribution we show how basin-hopping global optimization can identify low-lying minima for the corresponding mildly frustrated energy landscapes. For small systems the basin-hopping algorithm succeeds in locating both lower minima and conformations closer to the experimental structure than does molecular dynamics with simulated annealing. For large systems the efficiency of basin-hopping decreases for our initial implementation, where the steps consist of random perturbations to the Cartesian coordinates. We implemented umbrella sampling using basin-hopping to further confirm when the global minima are reached. We have also improved the energy surface by employing bioinformatic techniques for reducing the roughness or variance of the energy surface. Finally, the basin-hopping calculations have guided improvements in the excluded volume of the Hamiltonian, producing better structures. These results suggest a novel and transferable optimization scheme for future energy function development.

  2. Satellite altimetry over large hydrological basins

    Science.gov (United States)

    Calmant, Stephane

    2015-04-01

    The use of satellite altimetry for hydrological applications, either it is basin management or hydrological modeling really started with the 21st century. Before, during two decades, the efforts were concentrated on the data processing until a precision of a few decimeters could be achieved. Today, several web sites distribute hundreds of series spread over hundeds of rivers runing in the major basins of the world. Among these, the Amazon basin has been the most widely studied. Satellite altimetry is now routinely used in this transboundary basin to predict discharges ranging over 4 orders of magnitude. In a few years, satellite altimetry should evolve dramatically. This year, we should see the launchs of Jason-3 and that of Sentinel-3A operating in SAR mode. With SAR, the accuracy and resolution of a growing number of measurements should be improved. In 2020, SWOT will provide a full coverage that will join in a unique framework all the previous and forthcoming missions. These technical and thematical evolutions will be illustrated by examples taken in the Amazon and Congo basin.

  3. Performance analysis of double basin solar still with evacuated tubes

    International Nuclear Information System (INIS)

    Hitesh N Panchal; Shah, P. K.

    2013-01-01

    Solar still is a very simple device, which is used for solar distillation process. In this research work, double basin solar still is made from locally available materials. Double basin solar still is made in such a way that, outer basin is exposed to sun and lower side of inner basin is directly connected with evacuated tubes to increase distillate output and reducing heat losses of a solar still. The overall size of the lower basin is about 1006 mm x 325 mm x 380 mm, the outer basin is about 1006 mm x 536 mm x 100 mm Black granite gravel is used to increase distillate output by reducing quantity of brackish or saline water in the both basins. Several experiments have conducted to determine the performance of a solar still in climate conditions of Mehsana (latitude of 23 degree 59' and longitude of 72 degree 38'), Gujarat, like a double basin solar still alone, double basin solar still with different size black granite gravel, double basin solar still with evacuated tubes and double basin solar still with evacuated tubes and different size black granite gravel. Experimental results show that, connecting evacuated tubes with the lower side of the inner basin increases daily distillate output of 56% and is increased by 60%, 63% and 67% with average 10 mm, 20 mm and 30 mm size black granite gravel. Economic analysis of present double basin solar still is 195 days. (authors)

  4. Compaction and sedimentary basin analysis on Mars

    Science.gov (United States)

    Gabasova, Leila R.; Kite, Edwin S.

    2018-03-01

    Many of the sedimentary basins of Mars show patterns of faults and off-horizontal layers that, if correctly understood, could serve as a key to basin history. Sediment compaction is a possible cause of these patterns. We quantified the possible role of differential sediment compaction for two Martian sedimentary basins: the sediment fill of Gunjur crater (which shows concentric graben), and the sediment fill of Gale crater (which shows outward-dipping layers). We assume that basement topography for these craters is similar to the present-day topography of complex craters that lack sediment infill. For Gunjur, we find that differential compaction produces maximum strains consistent with the locations of observed graben. For Gale, we were able to approximately reproduce the observed layer orientations measured from orbiter image-based digital terrain models, but only with a >3 km-thick donut-shaped past overburden. It is not immediately obvious what geologic processes could produce this shape.

  5. Configuration Management Plan for K Basins

    International Nuclear Information System (INIS)

    Weir, W.R.; Laney, T.

    1995-01-01

    This plan describes a configuration management program for K Basins that establishes the systems, processes, and responsibilities necessary for implementation. The K Basins configuration management plan provides the methodology to establish, upgrade, reconstitute, and maintain the technical consistency among the requirements, physical configuration, and documentation. The technical consistency afforded by this plan ensures accurate technical information necessary to achieve the mission objectives that provide for the safe, economic, and environmentally sound management of K Basins and the stored material. The configuration management program architecture presented in this plan is based on the functional model established in the DOE Standard, DOE-STD-1073-93, open-quotes Guide for Operational Configuration Management Programclose quotes

  6. Acid/Caustic Basins: Environmental information document

    International Nuclear Information System (INIS)

    Ward, J.W.; Johnson, W.F.; Marine, I.W.

    1986-12-01

    There are six Acid/Caustic Basins at SRP, all of which are located in the reactor and separations areas. These basins are unlined earthen depressions with nominal dimensions of 15.2 m in length x 15.2 m in width x 2.1 m in depth. They were used to provide mixing and partial neutralization of dilute sulfuric acid and sodium hydroxide solutions from water treatment facilities before these solutions were discharged to tributaries of local streams. Closure options considered for the Acid/Caustic Basins are waste removal and closure, no waste removal and closure, and no action. The predominant pathways for human exposure to chemical contaminants are through surface, subsurface, and atmospheric transport. Modeling calculations were made to determine the risks to human population via general pathways for the three postulated closure options. A cost estimate for each closure was also made

  7. Configuration management compliance matrix for K Basins

    International Nuclear Information System (INIS)

    Laney, T.

    1995-01-01

    This compliance matrix identifies the criteria of the configuration management program at K Basins and identifies the current methods, i.e., systems, processes, procedures, and programs, that implement the configuration management criteria. The matrix identifies the current K Basins implementing methods established through an initial assessment. This initial assessment of the implementation is reflected in the compliance matrix and forms the basis for subsequent detailed evaluations to ensure that the identified implementation methods adequately support the configuration management program. Specific objectives of this matrix include: Identifying functional elements (criteria) of configuration management and K Basins implementation of these criteria; Assessing the conformance of the implementation and providing resolution for discrepancies; Recommending corrective actions or improvements for discrepant conditions; Providing a tracking database to status the discrepancy resolutions; and Identifying estimated schedules and resources for implementing discrepancy resolutions

  8. Engineering assessment of 105 K basin monorails

    International Nuclear Information System (INIS)

    Frier, W.A.

    1995-01-01

    The engineering assessment of the 105 K Basins monorails was performed to provide the engineering analysis to justify the existing basin north-south monorail capacity. The existing monorails have a capacity of 2400 lbs posted on the north-south monorails. The engineering assessment concluded that the monorail, hanger system, and trolleys all rate for a 2000 lb capacity. Based upon a 2,500 lb trolley load, the monorails, the hanger system, and the double trolley hoist system will rate for 2,500 lbs. The single trolley hoist system for handling the fuel canisters and the trolley systems used in the various transfer areas are limited by manufacturers to 2,000 lbs. Therefore, it is concluded from this engineering assessment that the 2,400 lb capacity posting for the north-south basin monorails is appropriate

  9. Water security evaluation in Yellow River basin

    Science.gov (United States)

    Jiang, Guiqin; He, Liyuan; Jing, Juan

    2018-03-01

    Water security is an important basis for making water security protection strategy, which concerns regional economic and social sustainable development. In this paper, watershed water security evaluation index system including 3 levels of 5 criterion layers (water resources security, water ecological security and water environment security, water disasters prevention and control security and social economic security) and 24 indicators were constructed. The entropy weight method was used to determine the weights of the indexes in the system. The water security index of 2000, 2005, 2010 and 2015 in Yellow River basin were calculated by linear weighting method based on the relative data. Results show that the water security conditions continue to improve in Yellow River basin but still in a basic security state. There is still a long way to enhance the water security in Yellow River basin, especially the water prevention and control security, the water ecological security and water environment security need to be promoted vigorously.

  10. Acoustic thermometry of the western Mediterranean basin

    Science.gov (United States)

    Skarsoulis, E. K.; Send, U.; Piperakis, G.; Testor, P.

    2004-08-01

    Ocean acoustic tomography is used to obtain heat-content estimates for the western Mediterranean basin. Travel-time data from 13 tomography sections of the Thetis-2 experiment (January-October 1994) are analyzed with a matched-peak inversion approach. The underlying analysis involves the use of peak arrivals and nonlinear model relations between travel-time and sound-speed variations. Slice inversion results are combined with temperature covariance functions for the western Mediterranean to obtain heat-content estimates for the basin. These estimates compare favorably with ECMWF data over the nine-month period of the Thetis-2 experiment. Furthermore, estimates for the basin-average temperature of the western Mediterranean deep water are obtained.

  11. Spatial Preference Heterogeneity for Integrated River Basin Management: The Case of the Shiyang River Basin, China

    Directory of Open Access Journals (Sweden)

    Fanus Asefaw Aregay

    2016-09-01

    Full Text Available Integrated river basin management (IRBM programs have been launched in most parts of China to ease escalating environmental degradation. Meanwhile, little is known about the benefits from and the support for these programs. This paper presents a case study of the preference heterogeneity for IRBM in the Shiyang River Basin, China, as measured by the Willingness to Pay (WTP, for a set of major restoration attributes. A discrete choice analysis of relevant restoration attributes was conducted. The results based on a sample of 1012 households in the whole basin show that, on average, there is significant support for integrated ecological restoration as indicated by significant WTP for all ecological attributes. However, residential location induced preference heterogeneities are prevalent. Generally, compared to upper-basin residents, middle sub-basin residents have lower mean WTP while lower sub-basin residents express higher mean WTP. The disparity in utility is partially explained by the difference in ecological and socio-economic status of the residents. In conclusion, estimating welfare benefit of IRBM projects based on sample responses from a specific sub-section of the basin only may either understate or overstate the welfare estimate.

  12. Great Basin geologic framework and uranium favorability

    International Nuclear Information System (INIS)

    Larson, L.T.; Beal, L.H.

    1978-01-01

    Work on this report has been done by a team of seven investigators assisted over the project span by twenty-three undergraduate and graduate students from May 18, 1976 to August 19, 1977. The report is presented in one volume of text, one volume or Folio of Maps, and two volumes of bibliography. The bibliography contains approximately 5300 references on geologic subjects pertinent to the search for uranium in the Great Basin. Volume I of the bibliography lists articles by author alphabetically and Volume II cross-indexes these articles by location and key word. Chapters I through IV of the Text volume and accompanying Folio Map Sets 1, 2, 3, 4, and 5, discuss the relationship of uranium to rock and structural environments which dominate the Great Basin. Chapter 5 and Map Sets 6 and 7 provide a geochemical association/metallogenic grouping of mineral occurrences in the Great Basin along with information on rock types hosting uranium. Chapter VI summarizes the results of a court house claim record search for 'new' claiming areas for uranium, and Chapter VII along with Folio Map Set 8 gives all published geochronological data available through April 1, 1977 on rocks of the Great Basin. Chapter VIII provides an introduction to a computer analysis of characteristics of certain major uranium deposits in crystalline rocks (worldwide) and is offered as a suggestion of what might be done with uranium in all geologic environments. We believe such analysis will assist materially in constructing exploration models. Chapter IX summarizes criteria used and conclusions reached as to the favorability of uranium environments which we believe to exist in the Great Basin and concludes with recommendations for both exploration and future research. A general summary conclusion is that there are several geologic environments within the Great Basin which have considerable potential and that few, if any, have been sufficiently tested

  13. Hydrogeology of the West Siberian Basin

    International Nuclear Information System (INIS)

    Foley, M.G.; Bradley, D.J.; Cole, C.R.

    1996-01-01

    Nuclear fuel cycle activities of the former Soviet Union (FSU) have resulted in extensive radioactive contaminant releases to the environment in western Siberia. We are developing three-dimensional numerical models of the hydrogeology and potential contaminant migration in the West Siberian Basin. We have assumed that ground-water flow in the West Siberian Basin is topographically driven, with recharge to the basin occurring in the highlands on the west, east, and south, and internal discharge localized in numerous river valleys and lakes that ultimately discharge north to the ocean. We are modeling the regional hydrogeology as three-dimensional, steady-state, saturated flow that is recharged from above. We acquired topographic, geologic, hydrostratigraphic, hydrogeologic, and water-balance data for the West Siberian Basin and constructed a regional water table. We correlated and combined 70 different rock types derived from published descriptions of West Siberian Basin rocks into 17 rock types appropriate for assignment of hydrogeologic properties on the basis of spatial heterogeneity and constituent (i.e., sand, silt, and clay) diversity. Examination of resulting three-dimensional assemblages of rock types showed that they were consistent with published and inferred paleogeography and depositional processes. Calibrating the basin's moisture balance (i.e., recharge and discharge) to the derived water table determined plausible input parameter values for unknowns such as hydraulic conductivities. The general directions of calculated ground-water flow suggest that major rivers act as discharge areas, with upwelling below the rivers extending down into the basement rocks, and that ground-water divides that penetrate the entire thickness of the model are evident between major rivers

  14. Paleohydrogeology of the San Joaquin basin, California

    Science.gov (United States)

    Wilson, A.M.; Garven, G.; Boles, J.R.

    1999-01-01

    Mass transport can have a significant effect on chemical diagenetic processes in sedimentary basins. This paper presents results from the first part of a study that was designed to explore the role of an evolving hydrodynamic system in driving mass transport and chemical diagenesis, using the San Joaquin basin of California as a field area. We use coupled hydrogeologic models to establish the paleohydrogeology, thermal history, and behavior of nonreactive solutes in the basin. These models rely on extensive geological information and account for variable-density fluid flow, heat transport, solute transport, tectonic uplift, sediment compaction, and clay dehydration. In our numerical simulations, tectonic uplift and ocean regression led to large-scale changes in fluid flow and composition by strengthening topography-driven fluid flow and allowing deep influx of fresh ground water in the San Joaquin basin. Sediment compaction due to rapid deposition created moderate overpressures, leading to upward flow from depth. The unusual distribution of salinity in the basin reflects influx of fresh ground water to depths of as much as 2 km and dilution of saline fluids by dehydration reactions at depths greater than ???2.5 km. Simulations projecting the future salinity of the basin show marine salinities persisting for more than 10 m.y. after ocean regression. Results also show a change from topography-to compaction-driven flow in the Stevens Sandstone at ca. 5 Ma that coincides with an observed change in the diagenetic sequence. Results of this investigation provide a framework for future hydrologic research exploring the link between fluid flow and diagenesis.

  15. Avian cholera in Nebraska's Rainwater Basin

    Science.gov (United States)

    Windingstad, R.M.; Hurt, J.J.; Trout, A.K.; Cary, J.

    1984-01-01

    The first report of avian cholera in North America occurred in northwestern Texas in winter 1944 (Quortrup et al. 1946). In 1975, mortality from avian cholera occurred for the first time in waterfowl in the Rainwater Basin of Nebraska when an estimated 25,000 birds died (Zinkl et al. 1977). Avian cholera has continued to cause mortality in wild birds in specific areas of the Basin each spring since. Losses of waterfowl from avian cholera continue to be much greater in some of the wetlands in the western part of the Basin than in the east. Several wetlands in the west have consistently higher mortality and are most often the wetlands where initial mortality is noticed each spring (Figure 1). The establishment of this disease in Nebraska is of considerable concern because of the importance of the Rainwater Basin as a spring staging area for waterfowl migrating to their breeding grounds. The wetlands in this area are on a major migration route used by an estimated 5 to 9 million ducks and several hundred thousand geese. A large portion of the western mid-continental greater white-fronted goose (Anser albifrons) population stage in the Basin each spring. Occasionally, whooping cranes (Grus americana) use these wetlands during migration, and lesser sandhill cranes (Grus canadensis) staging on the nearby Platte River sometimes use wetlands where avian cholera occurs (Anonymous 1981). Our objectives were to determine whether certain water quality variables in the Rainwater Basin differed between areas of high and low avian cholera incidence. These results would then be used for laboratory studies involving the survivability of Pasteurella multocida, the causative bacterium of avian cholera. Those studies will be reported elsewhere.

  16. Ground Motion Prediction Atop Geometrically Complex Sedimentary Basins - The Dead Sea Basin

    Science.gov (United States)

    Shani-Kadmiel, S.; Tsesarsky, M.; Louie, J. N.; Gvirtzman, Z.

    2014-12-01

    The Dead Sea Transform (DST) is the source for some of the largest earthquakes in the eastern Mediterranean. Several deep and structurally complex sedimentary basins are associated with the DST. These basins are up to 10 km deep and typically bounded by active fault zones. The low seismicity of the DST combined with the limited instrumental coverage of the seismic network in the area result in a critical knowledge gap. Therefore, it is necessary to complement the limited instrumental data with synthetic data based on computational modeling, in order to study the effects of earthquake ground motion in these sedimentary basins. We performed a 2D ground-motion analysis in the Dead Sea Basin (DSB) using a finite-difference code. Results indicate a complex pattern of ground motion amplification affected by the geometric features in the basin. To distinguish between the individual contributions of each geometrical feature in the basin, we developed a semiquantitative decomposition approach. This approach enabled us to interpret the DSB results as follows: (1) Ground-motion amplification as a result of resonance occurs basin-wide due to a high impedance contrast at the base of the uppermost layer; (2) Steep faults generate a strong edge-effect that further ampli- fies ground motions; (3) Sub-basins cause geometrical focusing that may significantly amplify ground motions; and (4) Salt diapirs diverge seismic energy and cause a de- crease in ground-motion amplitude. We address the significance of ground motion amplification due to geometrical focusing via an analytical and numerical study. We show that effective geometrical focusing occurs for a narrow set of eccentricities and velocity ratios, where seismic energy is converged to a region of ±0.5 km from surface. This mechanism leads to significant ground motion amplification at the center of the basin, up to a factor of 3; frequencies of the modeled spectrum are amplified up to the corner frequency of the source.

  17. Megafans of the Northern Kalahari Basin

    Science.gov (United States)

    Wilkinson, M. J.; Miller, R. McG.; Eckardt, F.; Kreslavsky, M. A.

    2016-01-01

    We identify eleven megafans (partial cones of fluvial sediment, >80 km radius) in the northern Kalahari Basin, using several criteria based on VIS and IR remotely sensed data and SRTM-based surface morphology reconstructions. Two other features meet fewer criteria of the form which we class as possible megafans. The northern Kalahari megafans are located in a 1700 km arc around the southern and eastern flanks of the Angola's Bié Plateau, from northern Namibia through northwest Botswana to western Zambia. Three lie in the Owambo subbasin centered on the Etosha Pan, three in the relatively small Okavango rift depression, and five in the Upper Zambezi basin. The population includes the well-known Okavango megafan (150 km), Namibia's Cubango megafan, the largest megafan in the region (350 km long), and the largest nested group (the five major contiguous megafans on the west slopes of the upper Zambezi Valley). We use new, SRTM-based topographic roughness data to discriminate various depositional surfaces within the flat N. Kalahari landscapes. We introduce the concepts of divide megafans, derived megafans, and fan-margin rivers. Conclusions. (i) Eleven megafan cones total an area of 190,000 sq km. (ii) Different controls on megafan size operate in the three component basins: in the Okavango rift structural controls become the prime constraint on megafan length by controlling basin dimensions. Megafans in the other les constricted basins appear to conform to classic relationships fan area, slope, and feeder-basin area. (iii) Active fans occupy the Okavango rift depression with one in the Owambo basin. The rest of the population are relict but recently active fans (surfaces are relict with respect to activity by the feeder river). (iv) Avulsive behavior of the formative river-axiomatic for the evolution of megafans-has resulted in repeated rearrangements of regional drainage, with likely effects in the study area well back into the Neogene. Divide megafans comprise the

  18. Ferromanganese nodules from the Central Indian Ocean Basin

    Digital Repository Service at National Institute of Oceanography (India)

    Jauhari, P.; Pattan, J.N.

    In order to delineate a mine site for ferromanganese nodules, extensive surveys were conducted in Central Indian Ocean Basin. Mapping of the basin by multibeam swath bathymetry (Hydrosweep) has revealed many new bottom relief features...

  19. Basin and Range Province, Western US, USGS Grids #4

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — These grid files were used to produce gravity and basin depth maps of the Basin and Range Province, western United States. The maps show gravity values and modeled...

  20. Basin and Range Province, Western US, USGS Grids, #1

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — These grid files were used to produce gravity and basin depth maps of the Basin and Range Province, western United States. The maps show gravity values and modeled...

  1. Hydrologic Sub-basins of Greenland, Version 1

    Data.gov (United States)

    National Aeronautics and Space Administration — The Hydrologic Sub-basins of Greenland data set contains Geographic Information System (GIS) polygon shapefiles that include 293 hydrologic sub-basins of the...

  2. Western Gas Sands Project. Quarterly basin activities report

    Energy Technology Data Exchange (ETDEWEB)

    1978-10-31

    This quarterly basin activities report is a summation of three months drilling and testing activities in the primary study areas of the WGSP; these include the Greater Green River Basin, the Northern Great Plains Province, the Piceance Basin, and the Uinta Basin. Additional low permeability sandstone areas are listed and located geographically. Activities in each primary study area are summarized under core program and dilling activity. (JRD)

  3. Hydrology of the Johnson Creek Basin, Oregon

    Science.gov (United States)

    Lee, Karl K.; Snyder, Daniel T.

    2009-01-01

    The Johnson Creek basin is an important resource in the Portland, Oregon, metropolitan area. Johnson Creek forms a wildlife and recreational corridor through densely populated areas of the cities of Milwaukie, Portland, and Gresham, and rural and agricultural areas of Multnomah and Clackamas Counties. The basin has changed as a result of agricultural and urban development, stream channelization, and construction of roads, drains, and other features characteristic of human occupation. Flooding of Johnson Creek is a concern for the public and for water management officials. The interaction of the groundwater and surface-water systems in the Johnson Creek basin also is important. The occurrence of flooding from high groundwater discharge and from a rising water table prompted this study. As the Portland metropolitan area continues to grow, human-induced effects on streams in the Johnson Creek basin will continue. This report provides information on the groundwater and surface-water systems over a range of hydrologic conditions, as well as the interaction these of systems, and will aid in management of water resources in the area. High and low flows of Crystal Springs Creek, a tributary to Johnson Creek, were explained by streamflow and groundwater levels collected for this study, and results from previous studies. High flows of Crystal Springs Creek began in summer 1996, and did not diminish until 2000. Low streamflow of Crystal Springs Creek occurred in 2005. Flow of Crystal Springs Creek related to water-level fluctuations in a nearby well, enabling prediction of streamflow based on groundwater level. Holgate Lake is an ephemeral lake in Southeast Portland that has inundated residential areas several times since the 1940s. The water-surface elevation of the lake closely tracked the elevation of the water table in a nearby well, indicating that the occurrence of the lake is an expression of the water table. Antecedent conditions of the groundwater level and autumn

  4. 48 CFR 25.405 - Caribbean Basin Trade Initiative.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Caribbean Basin Trade... SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Trade Agreements 25.405 Caribbean Basin Trade Initiative. Under the Caribbean Basin Trade Initiative, the United States Trade Representative has determined that, for...

  5. 100KE/KW fuel storage basin surface volumetric factors

    International Nuclear Information System (INIS)

    Conn, K.R.

    1996-01-01

    This Supporting Document presents calculations of surface Volumetric factors for the 100KE and 100KW Fuel Storage Basins. These factors relate water level changes to basin loss or additions of water, or the equivalent water displacement volumes of objects added to or removed from the basin

  6. Temporal precipitation trend analysis at the Langat River Basin ...

    Indian Academy of Sciences (India)

    The Langat River Basin provides fresh water for about 1.2 million people in the Langat and Klang valleys. Any change in the pattern of rainfall could affect the quantity of water in the basin. Studying the pattern of change in rainfall is crucial for managing the available water resources in the basin. Thus, in this study, for the ...

  7. Monthly water balance model for Ndarugu basin, Kenya | Nyadawa ...

    African Journals Online (AJOL)

    ... model in Ndarugu river basin in Kenya. The model is slightly modified to suit hydrologic conditions in the basin. The study apart from establishing relevant model parameters has recommended optimum length of period for continuous simulation to reduce effect dynamic changes in the basin. Journal of Civil Engineering, ...

  8. 13 Morphometric Analysis of Ogunpa and Ogbere Drainage Basins ...

    African Journals Online (AJOL)

    `123456789jkl''''#

    The paper analysed the morphometric parameters of Ogbere and Ogunpa drainage basins located on basement complex rock in ... properties of Ogunpa drainage basin are likely to induce high magnitude flood compared to morphometric properties of Ogbere ..... Bs = VI/HE where Bs = Basin slope, VI = Vertical Interval and.

  9. Detailed bathymetric surveys in the central Indian Basin

    Digital Repository Service at National Institute of Oceanography (India)

    Kodagali, V.N.; KameshRaju, K.A.; Ramprasad, T.; George, P.; Jaisankar, S.

    Over 420,000 line kilometers of echo-sounding data was collected in the Central Indian Basin. This data was digitized, merged with navigation data and a detailed bathymetric map of the Basin was prepared. The Basin can be broadly classified...

  10. The Interior Columbia Basin Ecosystem Management Project: scientific assessment.

    Science.gov (United States)

    1999-01-01

    This CD-ROM contains digital versions (PDF) of the major scientific documents prepared for the Interior Columbia Basin Ecosystem Management Project (ICBEMP). "A Framework for Ecosystem Management in the Interior Columbia Basin and Portions of the Klamath and Great Basins" describes a general planning model for ecosystem management. The "Highlighted...

  11. Riddled Basins of Attraction for Synchronized Type-I Intermittency

    DEFF Research Database (Denmark)

    Mancher, Martin; Nordahn, Morten; Mosekilde, Erik

    1998-01-01

    Chaotic mortion resticted to an invariant subspace of total phase space may be associated with basins of attraction that are riddled with holes belonging to the basin of another limiting state. We study the emergence of such basins of two coupled one-dimensional maps, each exhibiting type-I inter...

  12. 75 FR 43915 - Basin Electric Power Cooperative: Deer Creek Station

    Science.gov (United States)

    2010-07-27

    ... DEPARTMENT OF AGRICULTURE Rural Utilities Service Basin Electric Power Cooperative: Deer Creek... purpose of the EIS was to evaluate the potential environmental impacts of and alternatives to Basin Electric Power Cooperative's (Basin Electric) application for a RUS loan and a Western interconnection...

  13. Basin Subsegments from LDEQ source data, Geographic NAD83, LOSCO (2004) [basin_subsegments_LDEQ_2004

    Data.gov (United States)

    Louisiana Geographic Information Center — This is a polygon data set of watershed basin subsegments for Louisiana. The dataset was developed for the LDEQ Office of Water Resources' watershed assessment and...

  14. Quantification and Postglacial evolution of an inner alpine sedimentary basin (Gradenmoos Basin, Hohe Tauern)

    International Nuclear Information System (INIS)

    Götz, J.

    2012-01-01

    The overall objective of this thesis is the quantification of sediment storage and the reconstruction of postglacial landscape evolution within the glacially overdeepened Gradenmoos Basin (subcatchment size: 4.1 km 2 ; basin floor elevation: 1920 m) in the central Gradenbach catchment (Schober Range, Hohe Tauern, Austrian Alps). Following the approach of denudation-accumulation-systems, most reliable results are obtained (1) if sediment output of a system can be neglected for an established period of time, (2) if sediment storage can be assessed with a high level of accuracy, (3) if the onset of sedimentation and amounts of initially stored sediments are known, and (4) if sediment contributing areas can be clearly delimited. Due to spatial scale and topographic characteristics, all mentioned aspects are fulfilled to a high degree within the studied basin. Applied methods include surface, subsurface and temporal investigations. Digital elevation data is derived from terrestrial laserscanning and geomorphologic mapping. The quantification of sediment storage is based on core drillings, geophysical methods (DC resistivity, refraction seismic, and ground penetrating radar), as well as GIS and 3D modelling. Radiocarbon dating and palynological analyses are additionally used to reconstruct the postglacial infilling progress of the basin. The study reveals that a continuous postglacial stratigraphic record is archived in the basin. As proposed by Lieb (1987) timing of basin deglaciation could be verified to late-Egesen times by means of radiocarbon ages (oldest sample just above basal till: 10.4 ka cal. BP) and first palynologic results. Lateglacial oscillations seem to have effectively scoured the basin, leaving only a shallow layer of basal till. The analysis of postglacial sedimentation in the basin is further improved by the existence of a former lake in the basin lasting for up to 7500 years until approx. 3.7 ka cal. BP. Both, the stratigraphic (fine, partly

  15. A Basin Approach to a Hydrological Service Delivery System in the Amur River Basin

    Directory of Open Access Journals (Sweden)

    Sergei Borsch

    2018-03-01

    Full Text Available This paper presents the basin approach to the design, development, and operation of a hydrological forecasting and early warning system in a large transboundary river basin of high flood potential, where accurate, reliable, and timely available daily water-level and reservoir-inflow forecasts are essential for water-related economic and social activities (the Amur River basin case study. Key aspects of basin-scale system planning and implementation are considered, from choosing efficient forecast models and techniques, to developing and operating data-management procedures, to disseminating operational forecasts using web-GIS. The latter, making the relevant forecast data available in real time (via Internet, visual, and well interpretable, serves as a good tool for raising awareness of possible floods in a large region with transport and industrial hubs located alongside the Amur River (Khabarovsk, Komsomolsk-on-Amur.

  16. Seasonal Streamflow Forecasts for African Basins

    Science.gov (United States)

    Serrat-Capdevila, A.; Valdes, J. B.; Wi, S.; Roy, T.; Roberts, J. B.; Robertson, F. R.; Demaria, E. M.

    2015-12-01

    Using high resolution downscaled seasonal meteorological forecasts we present the development and evaluation of seasonal hydrologic forecasts with Stakeholder Agencies for selected African basins. The meteorological forecasts are produced using the Bias Correction and Spatial Disaggregation (BCSD) methodology applied to NMME hindcasts (North American Multi-Model Ensemble prediction system) to generate a bootstrap resampling of plausible weather forecasts from historical observational data. This set of downscaled forecasts is then used to drive hydrologic models to produce a range of forecasts with uncertainty estimates suitable for water resources planning in African pilot basins (i.e. Upper Zambezi, Mara Basin). In an effort to characterize the utility of these forecasts, we will present an evaluation of these forecast ensembles over the pilot basins, and discuss insights as to their operational applicability by regional actors. Further, these forecasts will be contrasted with those from a standard Ensemble Streamflow Prediction (ESP) approach to seasonal forecasting. The case studies presented here have been developed in the setting of the NASA SERVIR Applied Sciences Team and within the broader context of operational seasonal forecasting in Africa. These efforts are part of a dialogue with relevant planning and management agencies and institutions in Africa, which are in turn exploring how to best use uncertain forecasts for decision making.

  17. Integrated studies of Azraq Basin in Jordan

    Science.gov (United States)

    Mohammed Shahbaz; B. Sunna

    2000-01-01

    Many historical indications of the eastern Mediterranean Basin exhibit climatic changes or alterations effecting the status of water resources, hence, effecting human-kind and the quality of life. It is essential to deeply understand the nature of climates and geological structures employing state of the art techniques to assess rainfall, runoff, and floods that...

  18. On the significance of ELF basins

    Indian Academy of Sciences (India)

    For perfectly localized orbitals, the basins of ELF are the domains in which the probability of finding a pair of electrons is maximal. Author Affiliations. Andreas Savin1. Laboratoire de Chimie Théorique, CNRS and Université Pierre et Marie Curie, 4, Place Jussieu, F-75252 Paris, France. Journal of Chemical Sciences.

  19. Raptors of the Izdrevaya River Basin, Russia

    Directory of Open Access Journals (Sweden)

    Elvira G. Nikolenko

    2017-05-01

    Full Text Available This article compiles the results of episodic visits of the aurhoes to the basin of the Izdrevaya river during 2012–2016. The main goals of those visits were: to figure out the species composition of nesting fauna of birds of prey, estabishing the manner of nesting pairs’ distribution and designing a system of nestboxes for different species of birds of prey and owls. 8 species of Falconiformes are present in the Izdrevaya river basin, 4 of which are nesting, and 3 species of Strigiformes, 2 of which are nesting. The Black Kite (Milvus migrans has maximum density in the Izdrevaya river basin – 51.83 ind./100km2 (n=93. The Common Buzzard (Buteo buteo is the second in number after the Black Kite, its density being 8.88 ind/100km2 of the total area. The Ural Owl (Strix uralensis, encountered only on two territories in 2012, inhabited 4 nestboxes in 2013 as the result of biotechnical measures taken, and its number increased to 8 pairs successfully breeding in the nextboxes in 2016. Main negative factors for birds of prey in the Izdrevaya river basin were established: electrocution on power lines, illegal logging, illegal construction of dams and the construction of waste-sorting plant with a range of solid municipal waste.

  20. Climatology of the interior Columbia River basin.

    Science.gov (United States)

    Sue A. Ferguson

    1999-01-01

    This work describes climate means and trends in each of three major ecological zones and 13 ecological reporting units in the interior Columbia River basin. Widely differing climates help define each major zone and reporting unit, the pattern of which is controlled by three competing air masses: marine, continental, and arctic. Paleoclimatic evidence and historical...