WorldWideScience

Sample records for polar year initiative

  1. The Arctic Human Health Initiative: a legacy of the International Polar Year 2007–2009

    Science.gov (United States)

    Parkinson, Alan J.

    2013-01-01

    Background The International Polar Year (IPY) 2007–2008 represented a unique opportunity to further stimulate cooperation and coordination on Arctic health research and increase the awareness and visibility of Arctic regions. The Arctic Human Health Initiative (AHHI) was a US-led Arctic Council IPY coordinating project that aimed to build and expand on existing International Union for Circumpolar Health (IUCH) and Arctic Council human health interests. The project aimed to link researchers with potential international collaborators and to serve as a focal point for human health research, education, outreach and communication activities during the IPY. The progress of projects conducted as part of this initiative up until the end of the Arctic Council Swedish chairmanship in May 2013 is summarized in this report. Design The overall goals of the AHHI was to increase awareness and visibility of human health concerns of Arctic peoples, foster human health research, and promote health strategies that will improve health and well-being of all Arctic residents. Proposed activities to be recognized through the initiative included: expanding research networks that will enhance surveillance and monitoring of health issues of concern to Arctic peoples, and increase collaboration and coordination of human health research; fostering research that will examine the health impact of anthropogenic pollution, rapid modernization and economic development, climate variability, infectious and chronic diseases, intentional and unintentional injuries, promoting education, outreach and communication that will focus public and political attention on Arctic health issues, using a variety of publications, printed and electronic reports from scientific conferences, symposia and workshops targeting researchers, students, communities and policy makers; promoting the translation of research into health policy and community action including implementation of prevention strategies and health

  2. International Polar Year Historical Data and Literature

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The International Polar Year Historical Data and Literature collection (formerly known as the Discovery and Access of Historic Literature from the IPYs (DAHLI)...

  3. Advancing Environmental Prediction Capabilities for the Polar Regions and Beyond during The Year of Polar Prediction

    Science.gov (United States)

    Werner, Kirstin; Goessling, Helge; Hoke, Winfried; Kirchhoff, Katharina; Jung, Thomas

    2017-04-01

    Environmental changes in polar regions open up new opportunities for economic and societal operations such as vessel traffic related to scientific, fishery and tourism activities, and in the case of the Arctic also enhanced resource development. The availability of current and accurate weather and environmental information and forecasts will therefore play an increasingly important role in aiding risk reduction and safety management around the poles. The Year of Polar Prediction (YOPP) has been established by the World Meteorological Organization's World Weather Research Programme as the key activity of the ten-year Polar Prediction Project (PPP; see more on www.polarprediction.net). YOPP is an internationally coordinated initiative to significantly advance our environmental prediction capabilities for the polar regions and beyond, supporting improved weather and climate services. Scheduled to take place from mid-2017 to mid-2019, the YOPP core phase covers an extended period of intensive observing, modelling, prediction, verification, user-engagement and education activities in the Arctic and Antarctic, on a wide range of time scales from hours to seasons. The Year of Polar Prediction will entail periods of enhanced observational and modelling campaigns in both polar regions. With the purpose to close the gaps in the conventional polar observing systems in regions where the observation network is sparse, routine observations will be enhanced during Special Observing Periods for an extended period of time (several weeks) during YOPP. This will allow carrying out subsequent forecasting system experiments aimed at optimizing observing systems in the polar regions and providing insight into the impact of better polar observations on forecast skills in lower latitudes. With various activities and the involvement of a wide range of stakeholders, YOPP will contribute to the knowledge base needed to managing the opportunities and risks that come with polar climate change.

  4. Education and outreach for the International Polar Year

    Science.gov (United States)

    Pfirman, Stephanie; Bell, Robin Elizabeth; Turrin, Margie; Maru, Poonam

    2004-12-01

    If the 65 educators, scientists, and media specialists who gathered at the “Bridging the Poles” workshop in Washington, D.C. last June have their way a semitrailer truck labeled “Got Snow?” would traverse the country during the International Polar Year (IPY) of 2007-2009 loaded with polar gear, interactive activities, and a snowmaker. We would significantly increase the number of Arctic residents—especially indigenous Alaskans—with Ph.D.s. We would build exchange programs between inner city youths and polar residents. Polar exhibitions would open at natural history and art museums and zoos. And polar postage stamps, interactive polar computer games, national polar book-of-the-month recommendations, made-for-TV polar documentaries, and a polar youth forum would bring the poles front and center to the public's attention.

  5. Transfer of polarization from the initial to the final state in deep inelastic lepton scattering

    International Nuclear Information System (INIS)

    Bigi, I.I.Y.

    1977-01-01

    It is suggested to look for reactions of the type polarized lepton+nucleon→polarized baryon+anything or lepton+polarized nucleon→polarized baryon+anything in the deep inelastic region. The observation of such a transfer of polarization from the initial to the final (hadronic) state could yield information on the underlying dynamics; it also offers the possibility to find clear signals for the production of ''new'' hadrons like charmed baryons. (author)

  6. International Polar Year 2007: An Integrated Heliospheric and Oceanographic Program?

    Science.gov (United States)

    Johnson, G.; Davila, J.

    An international symposium SPerspectives of Modern Polar ResearchT was convened - in Bad Durkeim, Germany 2001 to celebrated the 175the anniversary of the birth of Georg von Neumayer. At that symposium the Nermayer Declaration was adopted to commemorate the 125th anniversary of the IPY in 2007. SA 125th year IPY program be initiated using new and present technologies to determine: 1 . Causes and effects of climatic variability-air/sea/ice interactins, and 2. Lithosphere dynamicsUevolution and history of crust and sedimentary cover. The po lar regions would be the focus.T Polar oceanographic contributions to global climate change are still a matter of conjecture, and to a large extent so are the extraterrestrial contributions. The proposed IPY would focus on these issues. As part of the global heat engine, the polar regions hav a major role in the worldSs transfer of energy, and the ocean/stmosphere system is known to be both an indicator and a componenet of climate change. It is clear that acomplex suite of significant, interrelated, atmospheric, oceanic and terrestrial changes has occurred in the the polsar regions in recent decades. These events are affecting every part of the polar environment and are having repercussions on society. In a similar vein an International Heliophysical Year (IHY) has been proposed to obtain a coordinated set of observations to study at the largest scale the solar genergated events that affect life and climate on Earth as has been documented in the Holocene sedimentary recofd. A modeling capability is the ultimate goal so the physical process can be tracked throughout the entire Sun-Earth system. This program will require an integrated, holistic system approach encompassing a side range of disciplines with new and improved technologies for long term measurements on the seabed, in the water column and in space over all seasons. Coordination, collaboration and documentation of an interated science plan with international scientific

  7. International Polar Year Historical Data and Literature, Version 1

    Data.gov (United States)

    National Aeronautics and Space Administration — The International Polar Year Historical Data and Literature collection (formerly known as the Discovery and Access of Historic Literature from the IPYs (DAHLI)...

  8. Understanding the Early Years (UEY) Initiative

    Science.gov (United States)

    Human Resources and Social Development Canada, 2007

    2007-01-01

    Internal Audit Services conducted an Early Implementation Review of the Understanding the Early Years (UEY) Initiative in 2006-07. This review is intended to provide assurance to senior management that program delivery has been established appropriately in order to meet its objectives and highlight any areas that require focused management…

  9. Canadian Preparations for the International Polar Year 2007-2008

    Science.gov (United States)

    Hik, D. S.; Edwards, K. E.

    2006-12-01

    The launch of the International Polar Year on March 1, 2007 will not only mark the beginning of data collection of innovative scientific programs but it will also unleash a series of innovative education and outreach opportunities to increase public awareness of the polar regions and their global impact. IPY education and outreach programs intend to enhance new methods of communication amongst international scientific partners and organizations; inspire the growth and engagement of the next generation of polar researchers; demystify scientific outcomes of IPY into relevant everyday impacts for the public; and express the wonder and significance of the polar regions through medium of art, exhibits, and writing. Canadian researchers, artists, educators and youth are providing significant leadership in the development of such IPY programming and are involved in almost half of the IPO endorsed EOC proposals. Recognizing that Canada has a critical role to play in IPY as host, leader and participant, preparations in Canada have been extensive. A network of national, territorial, and regional organizing bodies has been established to coordinate the development of the national IPY programs; to support the financial and logistical planning; as well as to facilitate the advancement of international partnerships. The success of the Canadian IPY program, measured as either capacity building, strength of partnerships, or efficiency of logistics and operations, will depend upon having committed partners who are specifically part of the Canadian IPY effort. As the Canadian IPY education and outreach program evolves it is being built firmly on partnerships with existing scientific and education organizations in Canada such as youth organizations, national media corporations, and polar science based programs. By building on existing national strengths we are able to capture the existing energy and activity from IPY 2007-2008 to create a longer term sustainable polar education

  10. The SPIRIT Telescope Initiative: six years on

    Science.gov (United States)

    Luckas, Paul

    2017-06-01

    Now in its sixth year of operation, the SPIRIT initiative remains unique in Australia, as a robust web-enabled robotic telescope initiative funded for education and outreach. With multiple modes of operation catering for a variety of usage scenarios and a fully supported education program, SPIRIT provides free access to contemporary astronomical tools for students and educators in Western Australia and beyond. The technical solution itself provides an excellent model for low cost robotic telescope installations, and the education program has evolved over time to include a broad range of student experiences-from engagement activities to authentic science. This paper details the robotic telescope solution, student interface and educational philosophy, summarises achievements and lessons learned and examines the possibilities for future enhancement including spectroscopy.

  11. Standardized monitoring of Rangifer health during International Polar Year

    Directory of Open Access Journals (Sweden)

    Susan Kutz

    2013-06-01

    Full Text Available Normal 0 21 false false false SV X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Normal tabell"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin-top:0cm; mso-para-margin-right:0cm; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0cm; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-fareast-language:EN-US;} Monitoring of individual animal health indices in wildlife populations can be a powerful tool for evaluation of population health, detecting changes, and informing management decisions. Standardized monitoring allows robust comparisons within and across populations, and over time and vast geographic regions. As an International Polar Year Initiative, the CircumArctic Rangifer Monitoring and Assessment network established field protocols for standardized monitoring of caribou and reindeer (Rangifer tarandus health, which included body condition, contaminants, and pathogen exposure and abundance. To facilitate use of the protocols, training sessions were held, additional resources were developed, and language was translated where needed. From March 2007 to September 2010, at least 1206 animals from 16 circumpolar herds were sampled in the field using the protocols. Four main levels of sampling were done and ranged from basic to comprehensive sampling. Possible sources of sampling error were noted by network members early in the process and protocols were modified or supplemented with additional visual resources to improve clarity when needed. This is the first time that such broad and comprehensive circumpolar sampling of migratory caribou and wild reindeer, using standardized protocols covering both body

  12. Initial Alignment for SINS Based on Pseudo-Earth Frame in Polar Regions.

    Science.gov (United States)

    Gao, Yanbin; Liu, Meng; Li, Guangchun; Guang, Xingxing

    2017-06-16

    An accurate initial alignment must be required for inertial navigation system (INS). The performance of initial alignment directly affects the following navigation accuracy. However, the rapid convergence of meridians and the small horizontalcomponent of rotation of Earth make the traditional alignment methods ineffective in polar regions. In this paper, from the perspective of global inertial navigation, a novel alignment algorithm based on pseudo-Earth frame and backward process is proposed to implement the initial alignment in polar regions. Considering that an accurate coarse alignment of azimuth is difficult to obtain in polar regions, the dynamic error modeling with large azimuth misalignment angle is designed. At the end of alignment phase, the strapdown attitude matrix relative to local geographic frame is obtained without influence of position errors and cumbersome computation. As a result, it would be more convenient to access the following polar navigation system. Then, it is also expected to unify the polar alignment algorithm as much as possible, thereby further unifying the form of external reference information. Finally, semi-physical static simulation and in-motion tests with large azimuth misalignment angle assisted by unscented Kalman filter (UKF) validate the effectiveness of the proposed method.

  13. Operational Cloud-to-Ground Lightning Initiation Forecasting Utilizing S-Band Dual-Polarization Radar

    Science.gov (United States)

    2014-03-27

    Kumjian, 2013a; 2013c). 2.6 Dual-Polarization Studies of Lightning Initiation Since the implementation of DP radar, meteorologist and...Course in Cloud Physics. Butterworth- Heinmann Pub. Rinehart, R. E., 2010: Radar for Meteorologists . 5th ed. Rinehart. Rutledge, S. A., and W. A

  14. Philadelphia's Renaissance Schools Initiative after Four Years

    Science.gov (United States)

    Stratos, Kati; Wolford, Tonya; Reitano, Adrienne

    2015-01-01

    In 2010-2011, the School District of Philadelphia (the District) launched its Renaissance Schools Initiative, a program designed to dramatically improve student achievement in the District's lowest performing schools. Some schools became Promise Academies, based on the federal turnaround model, and remained District-operated neighborhood schools.…

  15. Assessing Challenges and Opportunities for Education and Communication Activities for International Polar Year 2007-2008

    Science.gov (United States)

    McCaffrey, M. S.

    2005-05-01

    goals, contribute to building a lasting legacy for IPY, and support prior IPY Education and Outreach planning efforts, a Center for Polar Education and Coordination, and an online journal entitled the POLAR Post, modeled after the NASA Earth Observatory, have been proposed by the Outreach Department at the Cooperative Institute for Research in Environmental Sciences (CIRES) at the University of Colorado, in conjunction with the National Snow and Ice Data Center (NSIDC), the Institute for Arctic and Alpine Research (INSTAAR), and UCAR Education and Outreach. National Research Council (2004). A Vision for the International Polar Year. "Increasing Public Understanding and Participation in Polar Science Through the International Polar Year" and "Actions Needed to Make the International Polar Year Succeed." 65-79. National Research Council (2004). Planning for the International Polar Year 2007-2008: Report from the Implementation Workshop. "Data Education and Outreach Initiatives." 32-34.

  16. Optically initialized robust valley-polarized holes in monolayer WSe2

    KAUST Repository

    Hsu, Wei-Ting

    2015-11-25

    A robust valley polarization is a key prerequisite for exploiting valley pseudospin to carry information in next-generation electronics and optoelectronics. Although monolayer transition metal dichalcogenides with inherent spin–valley coupling offer a unique platform to develop such valleytronic devices, the anticipated long-lived valley pseudospin has not been observed yet. Here we demonstrate that robust valley-polarized holes in monolayer WSe2 can be initialized by optical pumping. Using time-resolved Kerr rotation spectroscopy, we observe a long-lived valley polarization for positive trion with a lifetime approaching 1 ns at low temperatures, which is much longer than the trion recombination lifetime (~10–20 ps). The long-lived valley polarization arises from the transfer of valley pseudospin from photocarriers to resident holes in a specific valley. The optically initialized valley pseudospin of holes remains robust even at room temperature, which opens up the possibility to realize room-temperature valleytronics based on transition metal dichalcogenides.

  17. An International Polar Year Adventure in the Arctic

    Science.gov (United States)

    Wartes, D.

    2008-12-01

    Native students in the UA system who participated in RAHI are nearly twice as likely to earn a bachelor's degree, than those who did not attend RAHI. The past two summers, in celebration of the International Polar Year, in collaboration with Ilisagvik College, at the completion of the traditional RAHI program, ten RAHI students flew to Barrow for an additional two weeks of study. Five students participated in an archaeological dig and five students performed research with the Barrow Arctic Science Consortium scientists studying climate change. And another student was the Alaskan delegate to the Students on Ice, a 2-week ship-based adventure in northern Canada. In addition, ten students from Greenland visited the program, with plans to more fully participate next summer. This added dimension to the program has proved successful, allowing the students to compare and contrast between their own countries and indigenous perspectives. Global warming was an issue that was hotly debated, as its effects are so evident in the Polar Regions. In the Arctic, one's life is directly tied to the ice and snow. As the ice disappears and/or changes, the Indigenous people have to adapt. RAHI would like to share with you some of the results of this past summer's IPY activities.

  18. Utilizing Four Dimensional Lightning and Dual-Polarization Radar to Develop Lightning Initiation Forecast Guidance

    Science.gov (United States)

    2015-03-26

    lightning based on size and composite Z alone. Since the focus was airmass thunderstorms, any days with complex areas or lines of thunder - storms...Doppler radar signatures of developing thunder - storms and their potential to indicate the onset of cloud-to-ground lightning . Mon. Wea. Rev., 122...UTILIZING FOUR DIMENSIONAL LIGHTNING AND DUAL-POLARIZATION RADAR TO DEVELOP LIGHTNING INITIATION FORECAST GUIDANCE THESIS Andrew J. Travis, Captain

  19. Leveraging the International Polar Year Legacy: Providing Historical Perspective for IPY Education, Outreach and Communication Efforts

    Science.gov (United States)

    Tsukernik, M.; McCaffrey, M. S.

    2006-12-01

    As the International Polar Year 2007-2008 (IPY) is fast approaching, it is important to look back and learn from the previous experience. Over 125 years ago, when an Austrian explorer and naval officer Lt. Karl Weyprecht called for an international yearlong intensive effort to study the Polar Regions, he probably never imagined that his model for international collaboration would become so widely popular. Frustrated by the lack of coordinated, international collaboration in research activities, Weyprecht proposed an intensive burst of research activity over the course of at least a year. The first IPY began in 1882 with 12 nations establishing 13 stations in the Arctic and 2 in the Southern Hemisphere. The initial yearlong plan did not go beyond data collection. However, the idea lived in the minds of scientists worldwide and the second IPY followed the first one 50 years later. By 1932, technology evolved significantly, and on top of ground-based meteorological and geophysical measurements, data collection also included radiosonde and acoustic atmospheric measurements. Occurring during a global economic depression, and between world wars, the second IPY faced many challenges. However, 40 permanent stations were established, some of which are still active. Scientific exploration also reached remote frontiers from Antarctica to the Earth's ionosphere. Less than a decade after the WWII, the idea of the next IPY started to circulate in scientific circles. The world was focused on space exploration and the word "polar" seemed too narrow for the gigantic projects planned for the 1957. That is why the initial idea of the third IPY evolved into the International Geophysical Year (IGY), although polar regions were still a major focus. The success of the IGY is almost overwhelming the first Earth orbiting satellites, a traverse of Antarctica, a discovery of the Radiation Belt, a series of science education films about IGY activities and research themes are just a few

  20. Initial investigations of (np)-scattering with a polarized deuterium target at ANKE-COSY

    Energy Technology Data Exchange (ETDEWEB)

    Gou, Boxing

    2015-07-01

    The understanding of the forces among nucleons is fundamental to the whole of nuclear and hadronic physics. The nucleon-nucleon (NN) scattering is the ideal probe to study the nuclear forces. The scattering amplitudes for the complete description of the NN interactions can be reconstructed from phase-shift analyses (PSA), which requires measurements with polarized experiments. The existing data allow to extract unambiguous proton-proton (pp) amplitudes below 2 GeV. However, there is very little known about the neutron-proton (np) system above 800 MeV nucleon energy. THE ANKE-COSY collaboration has embarked on a systematic program which aims to extract the np scattering amplitudes through the deuteron-proton charge-exchange process dp→{pp}{sub s}n. First part of the program via polarized deuteron beam and hydrogen target allowed successful measurement of np amplitudes up to 1.135 GeV nucleon energy, which is the maximum nucleon energy that can be accessed with deuteron beam at COSY. Via inverse kinematics, i.e. using a proton beam incident on a polarized deuterium target will allow to enhance the np study up to 2.8 GeV, the highest energy available at COSY. The method of inverse kinematics has to be validated prior to the production experiment. As the proof-of-principle (POP) experiment, the initial research has been conducted at proton energy T{sub p}=600 MeV using a polarized deuterium target. The projectiles were measured by two silicon tracking telescopes (STT) placed closed to the target and by the ANKE sub-detection systems. Four polarization modes of the deuterium target were employed. In order to increase the effective target thickness, polarized deuterium atoms produced by the atomic beam source (ABS) was filled into a storage cell, where the circulating COSY beam collides with the target. The target polarizations were measured using the proton-deuteron elastic reaction. The vector and tensor analyzing powers A{sub y} and A{sub yy} of pvector d

  1. POLAR-PALOOZA Polar Researchers and Arctic Residents Engage, Inform and Inspire Diverse Public Audiences by sharing Polar Science and Global Connections during the International Polar Year, using a New Model of Informal Science Education

    Science.gov (United States)

    Haines-Stiles, G.; Akuginow, E.

    2006-12-01

    (Please note that the POLAR-PALOOZA initiative described in this Abstract is-as of 9/7/2006-"pending" for possible support from NSF and NASA as part of this year's IPY solicitation. Subject to decisions expected by 9/30, this presentation would either be withdrawn, or amplified with specific participants, locations and dates.) Despite the success of well-regarded movies like "March of the Penguins", the polar regions remain a great unknown for most people. Public knowledge about the Arctic and Antarctic, and the critical role of the Poles in the entire Earth system, is nonexistent, incomplete or burdened with misperceptions. The International Polar Years of 2007-2009-and associated "I*Y" science years such as IHY, IYPE and eGY-present a unique opportunity to change this. The people who can best effect this change are those who know the Poles best, through living or working there. Based on innovative but proven models, POLAR-PALOOZA will use three complementary strategies to engage, inform and inspire large public audiences. (1) A national tour, under the working title "Stories from a Changing Planet", will include in-person presentations at science centers, museums, libraries and schools across North America, including Canada and Mexico. The presentations will be augmented by High Definition Video taped on location at the Poles, audio and video podcasts, and special education and outreach activities for targeted audiences. "Stories from a Changing Planet" will provide diverse audiences with an exciting opportunity to meet and interact directly with polar experts, and to appreciate why the Poles and the research done there are directly relevant to their lives. (2) The "HiDef Video Science Story Capture Corps" is a team of professional videographers, using the latest generation of low-cost, high-quality cameras, deployed to both Poles. They will document the work of multiple researchers and projects, rather than focusing on one topic for a single broadcast program

  2. Axon Initial Segment Cytoskeleton: Architecture, Development, and Role in Neuron Polarity.

    Science.gov (United States)

    Jones, Steven L; Svitkina, Tatyana M

    2016-01-01

    The axon initial segment (AIS) is a specialized structure in neurons that resides in between axonal and somatodendritic domains. The localization of the AIS in neurons is ideal for its two major functions: it serves as the site of action potential firing and helps to maintain neuron polarity. It has become increasingly clear that the AIS cytoskeleton is fundamental to AIS functions. In this review, we discuss current understanding of the AIS cytoskeleton with particular interest in its unique architecture and role in maintenance of neuron polarity. The AIS cytoskeleton is divided into two parts, submembrane and cytoplasmic, based on localization, function, and molecular composition. Recent studies using electron and subdiffraction fluorescence microscopy indicate that submembrane cytoskeletal components (ankyrin G, βIV-spectrin, and actin filaments) form a sophisticated network in the AIS that is conceptually similar to the polygonal/triangular network of erythrocytes, with some important differences. Components of the AIS cytoplasmic cytoskeleton (microtubules, actin filaments, and neurofilaments) reside deeper within the AIS shaft and display structural features distinct from other neuronal domains. We discuss how the AIS submembrane and cytoplasmic cytoskeletons contribute to different aspects of AIS polarity function and highlight recent advances in understanding their AIS cytoskeletal assembly and stability.

  3. Development of a Next Generation Polar Multidisciplinary Airborne Imaging System for the International Polar Year 2007-2009

    Science.gov (United States)

    Bell, R. E.; Studinger, M.; Frearson, N.; Gogineni, P.; Braaten, D.

    2007-12-01

    Key elements in Earth's geodynamic and climatic systems, the polar regions are very sensitive to changing global environmental conditions such as increasing sea surface temperatures and have the potential to trigger significant global sea level rise as large volumes of ice melt. Locked within these icy regions are the records of past global climate shifts and novel ecosystems sealed from open interactions with the atmosphere for millions of years. While satellite missions can image the surface of the polar ice sheet, many of the key processes occur beneath the surface beyond the reach of space based observations. These crucial processes can only be efficiently examined through airborne instrumentation designed to study the vast expanses of snow and ice of the Antarctic continent, the sub-continent of Greenland and the surrounding oceans. The expanding logistical infrastructure associated with the International Polar Year (2007-2009) will enable the scientific community access major new portions of the polar regions. We are developing a state-of-the-art integrated multidisciplinary aerogeophysical instrumentation package for deployment during multi-national expeditions as part of the International Polar Year. This development project brings together the recent developments in radar sounding by the University of Kansas CReSIS (Center for Remote Sensing of Ice Sheets), that now permit the full characterization of the entire ice sheet and the major advances in the accuracy, resolution and efficiency of airborne gravity technology emerging from the private sector. Integrating the full spectrum of ice sheet imaging with high-resolution gravity and magnetics will enable the imaging of the previously invisible world of subglacial hydrodynamics.

  4. Ultrastructural analyses of somatic embryo initiation, development and polarity establishment from mesophyll cells of Dactylis glomerata

    Science.gov (United States)

    Vasilenko, A.; McDaniel, J. K.; Conger, B. V.

    2000-01-01

    Somatic embryos initiate and develop directly from single mesophyll cells in in vitro-cultured leaf segments of orchardgrass (Dactylis glomerata L.). Embryogenic cells establish themselves in the predivision stage by formation of thicker cell walls and dense cytoplasm. Electron microscopy observations for embryos ranging from the pre-cell-division stage to 20-cell proembryos confirm previous light microscopy studies showing a single cell origin. They also confirm that the first division is predominantly periclinal and that this division plane is important in establishing embryo polarity and in determining the embryo axis. If the first division is anticlinal or if divisions are in random planes after the first division, divisions may not continue to produce an embryo. This result may produce an embryogenic cell mass, callus formation, or no structure at all. Grant numbers: NAGW-3141, NAG10-0221.

  5. Concordia, Antarctica, seismic experiment for the International Polar Year (CASE-IPY

    Directory of Open Access Journals (Sweden)

    Alessia Maggi

    2014-06-01

    Full Text Available The CASE-IPY project, part of the larger POLENET initiative of geophysical observations for the International Polar Year, was built on our extensive experience of running seismological stations in Antarctica, both on rock sites (Dumont d’Urville station, and directly on the ice plateau (Concordia station. For CASE-IPY, we deployed 8 temporary seismic stations on the Antarctic plateau: 3 situated near Concordia itself (starting 2008, and the other 5 regularly spaced between Concordia and Vostok (2010-2012, following the maximum in ice topography. The technical problems we have encountered in our field deployments were essentially due to a combination of extreme environmental conditions and isolation of deployment sites. The 3 stations near Concordia were used as test sites to experiment different solutions, and to converge on a design for the 5 main stations. Results from the nearest stations, which transmit data regularly to Concordia, are very promising. The data recorded by our stations will be distributed widely in the scientific community. We expect them to be exploited essentially for structural studies involving Antarctica itself (its ice-cap, crust and lithosphere via receiver functions, noise correlation, and surface-wave tomography, but also for studies of the Earth’s core.

  6. A Rising Tide for Polar Science: Efforts of the U.S. National Committee for the International Polar Year

    Science.gov (United States)

    Albert, M. R.

    2003-12-01

    The polar regions, fascinating yet distant and cold places, hold the keys to our changing world. While the upcoming IPY is the 50th anniversary of the International Geophysical Year and the 125th anniversary of the first International Polar Year, it also falls at a crucial time in rapid changes in environmental and social systems that may affect all peoples of the Earth. Further warming of the Arctic, changing ecosystems and opening pathways for ocean travel, impact not only the people there but also the shipping, economics, and strategic considerations of distant nations. Yet potential further warming of the Arctic may be understood by clues in the Antarctic ice. How are the polar regions changing, and how swiftly may those changes affect the entire Earth? This is but one question emerging from community discussions of the science of the upcoming IPY. Our emerging ability to investigate previously unexplored areas is increasing our understanding of the wide world we live in, through interdisciplinary studies and tools for connections. Autonomous vehicles, genomics, and remote sensing technologies are just a few of the emerging areas that may provide new tools for investigating previously inaccessible realms. At the same time, tools such as the internet are making the world smaller, enabling instant communications between the peoples of the world. Joint international investigations enhance our ability to understand one another as well as our ability to understand our world and our universe. Rapid communications and international involvement can revolutionize the way we educate young scientists and our future leaders in a complex and changing world. Involving and educating people - young scientists, college students, school children, and the public - will be included as hallmarks of the IPY. The people are here. New tools are emerging. The ideas, or scientific goals, of the IPY are being crafted jointly through broad involvement of the scientific community, through

  7. Celebrate with SATELLITES: An International Polar Year Partnership to Study Earth's Materials

    Science.gov (United States)

    Hedley, Mikell Lynne; Czajkowski, Kevin; Struble, Janet; Benko, Terri; Shellito, Brad; Sheridan, Scott; Stasiuk, Mandy Munroe

    2009-01-01

    The SATELLITES program uses geospatial technologies to study surface temperatures of Earth's materials, such as sand, soil, grass, and water. Data are collected using Global Learning and Observations to Benefit the Environment (GLOBE) protocols, which are then used in research projects that are a part of the International Polar Year (IPY).…

  8. Thermal state of permafrost in North America: a contribution to the international polar year

    Science.gov (United States)

    S.L. Smith; V.E. Romanovsky; A.G. Lewkowicz; C.R. Burn; M. Allard; G.D. Clow; K. Yoshikawa; J. Throop

    2010-01-01

    A snapshot of the thermal state of permafrost in northern North America during the International Polar Year (IPY) was developed using ground temperature data collected from 350 boreholes. More than half these were established during IPY to enhance the network in sparsely monitored regions. The measurement sites span a diverse range of ecoclimatic and geological...

  9. A Modeling Study of the Initial Formation of Polar Lows in the Vicinity of the Arctic Front

    Directory of Open Access Journals (Sweden)

    Igor Mingalev

    2014-01-01

    Full Text Available A regional mathematical model of the wind system of the lower atmosphere, developed recently in the Polar Geophysical Institute, is applied to investigate the initial stage of the formation of polar lows at latitudes of the European Arctic. The mathematical model is based on numerical solving of nonsimplified gas dynamic equations and produces three-dimensional distributions of the atmospheric parameters in the height range from 0 to 15 km over a limited region of the Earth’s surface. Simulation results indicated that the origin of a convexity in the configuration of the arctic front can lead to the formation of a polar low during the period of about one day.

  10. The SPIRIT Telescope Initiative: Six Years On (Abstract)

    Science.gov (United States)

    Luckas, P.

    2017-12-01

    (Abstract only) Now in its sixth year of operation, the SPIRIT initiative remains unique in Australia, as a robust web-enabled robotic telescope initiative funded for education and outreach. With multiple modes of operation catering for a variety of usage scenarios and a fully supported education program, SPIRIT provides free access to contemporary astronomical tools for students and educators in Western Australia and beyond. The technical solution itself provides an excellent model for low cost robotic telescope installations, and the education program has evolved over time to include a broad range of student experiences - from engagement activities to authentic science. This paper details the robotic telescope solution, student interface, and educational philosophy, summarizes achievements and lessons learned, and examines the possibilities for future enhancement including spectroscopy.

  11. Changes in aerobic performance, body composition, and physical activity in polar explorers during a year-long stay at the polar station in the Arctic

    Science.gov (United States)

    Maciejczyk, Marcin; Araźny, Andrzej; Opyrchał, Marta

    2017-04-01

    The aim of this study was to evaluate changes in physical activity, aerobic performance, and body composition in polar explorers during a 1-year stay at the polar station. The study group consisted of 10 people, including 8 men and 2 women. Aerobic performance (maximal oxygen uptake), physical activity, body mass, and composition were evaluated for the polar explores of the Polish Polar Station prior to departure, and then during their stay at the station for a period of 1 year. The measurements were performed every 3 months. Compared to the measurements taken before going to the polar station, aerobic performance significantly ( p = 0.02) increased in the first 3 months of residing at the polar station and then remained relatively stable for the following duration of the stay. In the first 3 months of the stay, we also observed the highest level of physical activity in participants. In the polar explorers, no significant ( p > 0.05) body fatness changes were noted. Nonetheless, lean body mass, body mass, and BMI significantly increased compared to the measurements taken before departure to the polar station. The greatest changes in aerobic performance, physical activity, and body composition were observed during the first 3 months after arrival to the Arctic and then, despite changing biometeorological conditions, they remained stable for the next months of the stay. We recommend the introduction of a physical preparation program before departing to the polar station to improve explorers' physical fitness, so that they can meet the physical challenges they are faced with immediately after arrival to the polar station.

  12. The University of Delaware Carlson International Polar Year Events: Collaborative and Educational Outreach

    Science.gov (United States)

    Nelson, F. E.; Bryant, T.; Wellington, P.; Dooley, J.; Bird, M.

    2008-12-01

    Delaware is a small state with, by virtue of its coastal location, a large stake in climatic change in the polar regions. The University of Delaware has maintained a strong presence in cold-regions research since the mid-1940s, when William Samuel Carlson, a highly accomplished Arctic explorer, military strategist, and earth scientist, was named 20th President (1946-50) of the University. Carlson played a leading role in two of the University of Michigan's Greenland expeditions in the late 1920s and early 1930s. As Director of the Arctic, Desert, and Tropic Branch of the US Army Air Forces Tactical Center during World War II, Colonel Carlson played a role in developing several air transportation routes through the Arctic that helped to facilitate the Allied victory in Europe. Carlson authored many scientific and popular publications concerned with the Arctic, including the books Greenland Lies North (1940) and Lifelines Through the Arctic (1962). Although the University of Delaware has maintained a vigorous and continuous program of polar research since Carlson's tenure, the faculty, staff, and students involved are diffused throughout the University's colleges and departments, without an institutional focal point. Consequently, although many of these individuals are well known in their respective fields, the institution has not until recently been perceived widely as a center of polar-oriented research. The goals of the Carlson International Polar Year Events are to: (a) develop a sense of community among UD's diffuse polar-oriented researchers and educators; (b) create a distinctive and highly visible role for UD in the milieu of IPY activities; (c) promote interest in and knowledge about the polar regions in the State of Delaware, at all educational levels; (d) forge a close relationship between UD and the American Geographical Society, a national organization involved closely with previous International Polar Years; and (e) create a new basis for development

  13. Knowledge Discovery in our World Information Society: Opportunities for the International Polar Year 2007-08

    Science.gov (United States)

    Berkman, P. A.

    2005-12-01

    The World Data Center system emerged in 1957-58 with the International Geophysical Year (which was renamed from the 3rd International Polar Year) to preserve and provide access to scientific data collected from observational programs throughout the Earth system. Fast forward a half century ... access to diverse digital information has become effectively infinite and instantaneous with nearly 20,000 petabytes of information produced and stored on print, optical and magnetic media each year; microprocessor speeds that have increased 5 orders of magnitude since 1972; existence of the Internet; increasing global capacity to collect and transmit information via satellites; availability of powerful search engines; and proliferation of data warehouses like the World Data Centers. The problem is that we already have reached the threshold in our world information society when accessing more information does not equate with generating more knowledge. In 2007-08, the International Council of Science and World Meteorological Organization will convene the next International Polar Year to accelerate our understanding of how the polar regions respond to, amplify and drive changes elsewhere in the Earth system (http://www.ipy.org). Beyond Earth system science, strategies and tools for integrating digital information to discover meaningful relationships among the disparate data would have societal benefits from boardrooms to classrooms. In the same sense that human-launched satellites became a strategic focus that justified national investments in the International Geophysical Year, developing the next generation of knowledge discovery tools is an opportunity for the International Polar Year 2007-08 and its affiliated programs to contribute in an area that is critical to the future of our global community. Knowledge is the common wealth of humanity. H.E. Mr. Adama Samassekou President, World Summit on the Information Society

  14. Fifty Years of Soviet and Russian Drilling Activity in Polar and Non-Polar Ice: A Chronological History

    National Research Council Canada - National Science Library

    Ueda, Herbert T; Talalay, Pavel G

    2007-01-01

    Soviet and Russian drilling activity in ice began in 1955 while conducting temperature surveys on a glacier in Franz-Josef Land in the Arctic and continued to 1960 on the glaciers of the polar Ural...

  15. Economic Polarization Across European Union Regions in the years 2007–2012 at NUTS 2 Level

    Directory of Open Access Journals (Sweden)

    Piętak Łukasz

    2016-12-01

    Full Text Available The aim of this paper is to study the economic polarization in countries of the EU at NUTS 2 level in the years 2007–2012. The studies have to decide on positive or negative verification of the hypothesis, which states that the economic crisis of 2008–2013 had an influence on rising economic polarization in EU countries. The method used in this article is an application of some measures of economic polarization and inequality of income distribution. The carried out research did not allow for the positive verification of the hypothesis. Only in a few countries did the economic crisis have an influence on a reduction of the middle class. In most cases the economic collapse did not play any role in the raising of the economic polarization index. The statistical data used in this paper was taken from the following databases: Statistical Yearbook of the Regions – Poland from 2009 to 2013 and Eurostat – Regional statistics by NUTS classification*.

  16. Monitoring the initiation and kinetics of human dendritic cell-induced polarization of autologous naive CD4+ T cells.

    Directory of Open Access Journals (Sweden)

    Tammy Oth

    Full Text Available A crucial step in generating de novo immune responses is the polarization of naive cognate CD4+ T cells by pathogen-triggered dendritic cells (DC. In the human setting, standardized DC-dependent systems are lacking to study molecular events during the initiation of a naive CD4+ T cell response. We developed a TCR-restricted assay to compare different pathogen-triggered human DC for their capacities to instruct functional differentiation of autologous, naive CD4+ T cells. We demonstrated that this methodology can be applied to compare differently matured DC in terms of kinetics, direction, and magnitude of the naive CD4+ T cell response. Furthermore, we showed the applicability of this assay to study the T cell polarizing capacity of low-frequency blood-derived DC populations directly isolated ex vivo. This methodology for addressing APC-dependent instruction of naive CD4+ T cells in a human autologous setting will provide researchers with a valuable tool to gain more insight into molecular mechanisms occurring in the early phase of T cell polarization. In addition, it may also allow the study of pharmacological agents on DC-dependent T cell polarization in the human system.

  17. Polar Processes in a 50-year Simulation of Stratospheric Chemistry and Transport

    Science.gov (United States)

    Kawa, S.R.; Douglass, A. R.; Patrick, L. C.; Allen, D. R.; Randall, C. E.

    2004-01-01

    The unique chemical, dynamical, and microphysical processes that occur in the winter polar lower stratosphere are expected to interact strongly with changing climate and trace gas abundances. Significant changes in ozone have been observed and prediction of future ozone and climate interactions depends on modeling these processes successfully. We have conducted an off-line model simulation of the stratosphere for trace gas conditions representative of 1975-2025 using meteorology from the NASA finite-volume general circulation model. The objective of this simulation is to examine the sensitivity of stratospheric ozone and chemical change to varying meteorology and trace gas inputs. This presentation will examine the dependence of ozone and related processes in polar regions on the climatological and trace gas changes in the model. The model past performance is base-lined against available observations, and a future ozone recovery scenario is forecast. Overall the model ozone simulation is quite realistic, but initial analysis of the detailed evolution of some observable processes suggests systematic shortcomings in our description of the polar chemical rates and/or mechanisms. Model sensitivities, strengths, and weaknesses will be discussed with implications for uncertainty and confidence in coupled climate chemistry predictions.

  18. Estimation of Melt Pond Fractions on First Year Sea Ice Using Compact Polarization SAR

    Science.gov (United States)

    Li, Haiyan; Perrie, William; Li, Qun; Hou, Yijun

    2017-10-01

    Melt ponds are a common feature on Arctic sea ice. They are linked to the sea ice surface albedo and transmittance of energy to the ocean from the atmosphere and thus constitute an important process to parameterize in Arctic climate models and simulations. This paper presents a first attempt to retrieve the melt pond fraction from hybrid-polarized compact polarization (CP) SAR imagery, which has wider swath and shorter revisit time than the quad-polarization systems, e.g., from RADARSAT-2 (RS-2). The co-polarization (co-pol) ratio has been verified to provide estimates of melt pond fractions. However, it is a challenge to link CP parameters and the co-pol ratio. The theoretical possibility is presented, for making this linkage with the CP parameter C22/C11 (the ratio between the elements of the coherence matrix of CP SAR) for melt pond detection and monitoring with the tilted-Bragg scattering model for the ocean surface. The empirical transformed formulation, denoted as the "compact polarization and quad-pol" ("CPQP") model, is proposed, based on 2062 RS-2 quad-pol SAR images, collocated with in situ measurements. We compared the retrieved melt pond fraction with CP parameters simulated from quad-pol SAR data with results retrieved from the co-pol ratio from quad-pol SAR observations acquired during the Arctic-Ice (Arctic-Ice Covered Ecosystem in a Rapidly Changing Environment) field project. The results are shown to be comparable for observed melt pond measurements in spatial and temporal distributions. Thus, the utility of CP mode SAR for melt pond fraction estimation on first year level ice is presented.

  19. Formylation of initiator tRNA methionine in procaryotic protein synthesis: in vivo polarity in lactose operon expression.

    Science.gov (United States)

    Petersen, H U; Joseph, E; Ullmann, A; Danchin, A

    1978-01-01

    Eucaryotic and procaryotic organisms differ in two aspects of their translation machinery: polycistronic messengers are expressed as a sequence of individual proteins only in procaryotes, and the initiation of protein synthesis proceeds with an initiator tRNA which is found to be modified (formylated) in procaryotes and not in eucaryotes. In the present study, we show that formylation is required in vivo for the coordinate expression of the Escherichia coli lactose operon. Our experiments are consistent with a translation mechanism using dissociated ribosomes at the 5' end of the mRNA in a reaction that is only weakly dependent on formylation at this initiation step; the ribosomes then travel along the messenger and can reinitiate after the intracistronic barrier without dissociation. This latter initiation step is strongly dependent on the level of formylation: a low level of the formyl group, obtained by the antifolic agent trimethoprim, induces a strong polarity in the expression of the lactose operon. There exist mutant strains in which this polarity is much less apparent than in the wild type. We show here that such is the case of rpsL mutants. Ribosomes mutated in the S12 protein (rpsL) are found to be much more easily dissociated than the wild type. This might explain why the expression of the lactose operon on rpsL strains remains coordinated when the intracellular level of formylation is decreased. PMID:98518

  20. Proteomics Standards Initiative: Fifteen Years of Progress and Future Work.

    Science.gov (United States)

    Deutsch, Eric W; Orchard, Sandra; Binz, Pierre-Alain; Bittremieux, Wout; Eisenacher, Martin; Hermjakob, Henning; Kawano, Shin; Lam, Henry; Mayer, Gerhard; Menschaert, Gerben; Perez-Riverol, Yasset; Salek, Reza M; Tabb, David L; Tenzer, Stefan; Vizcaíno, Juan Antonio; Walzer, Mathias; Jones, Andrew R

    2017-12-01

    The Proteomics Standards Initiative (PSI) of the Human Proteome Organization (HUPO) has now been developing and promoting open community standards and software tools in the field of proteomics for 15 years. Under the guidance of the chair, cochairs, and other leadership positions, the PSI working groups are tasked with the development and maintenance of community standards via special workshops and ongoing work. Among the existing ratified standards, the PSI working groups continue to update PSI-MI XML, MITAB, mzML, mzIdentML, mzQuantML, mzTab, and the MIAPE (Minimum Information About a Proteomics Experiment) guidelines with the advance of new technologies and techniques. Furthermore, new standards are currently either in the final stages of completion (proBed and proBAM for proteogenomics results as well as PEFF) or in early stages of design (a spectral library standard format, a universal spectrum identifier, the qcML quality control format, and the Protein Expression Interface (PROXI) web services Application Programming Interface). In this work we review the current status of all of these aspects of the PSI, describe synergies with other efforts such as the ProteomeXchange Consortium, the Human Proteome Project, and the metabolomics community, and provide a look at future directions of the PSI.

  1. Princess Elisabeth Antarctica: an International Polar Year outreach and media success story

    Directory of Open Access Journals (Sweden)

    Joseph Cheek

    2011-12-01

    Full Text Available One of the priorities of the fourth International Polar Year (IPY was to increase awareness of the polar regions and polar science among the general public through education, communication and other forms of outreach. This paper reports on the media coverage of Princess Elisabeth Antarctica (PEA, Belgium's “zero-emission” Antarctic research station designed by the non-profit International Polar Foundation (IPF to run on wind and solar energy and to employ state-of-the-art forms of energy management and other “green” technology. This paper provides background information on PEA, a review of IPF's media strategy for the project, a description of media coverage of the station and a discussion of the way in which the IPF's main messages were reported in the media. IPF staff surveyed approximately 300 media reports released between February 2004, when the PEA project was announced to the general public, and June 2010, when the IPF presented their findings at the IPY conference in Oslo. PEA was featured 580 times in print and web media in Belgium, and 303 times outside Belgium. Major international agencies such as the Associated Press, Agence France Presse, the BBC, Al-Jazeera and Reuters covered the project. On television and radio, PEA was featured in news broadcasts from all four major television networks in Belgium, most major radio stations and 34 different television and radio news outlets outside Belgium. The paper concludes that the media coverage for PEA was significant and suggests reasons why the project was so widely reported.

  2. Building on the International Polar Year: Discovering Interdisciplinary Data Through Federated Search

    Directory of Open Access Journals (Sweden)

    L Yarmey

    2014-10-01

    Full Text Available The legacy of the International Polar Year 2007–2008 (IPY includes advances in open data and meaningful progress towards interoperability of data, systems, and standards. Enabled by metadata brokering technologies and by the growing adoption of international metadata standards, federated data search welcomes diversity in Arctic data and recognizes the value of expertise in community data repositories. Federated search enables specialized data holdings to be discovered by broader audiences and complements the role of metadata registries such as the Global Change Master Directory, providing interoperability across the Arctic web-of-repositories.

  3. What is happening in the International Polar Year? Latest news about the climate changes

    International Nuclear Information System (INIS)

    Orheim, Olav

    2008-01-01

    The International Polar (IPY) Year 2007-2008 is a large scientific programme focused on the Arctic and the Antarctic. Scientists from over 60 nations participates. The IPY have two primary objectives: to improve weather forecasts especially regarding extreme weather and to improve climatic models for better understanding of possible instabilities, especially regarding ocean currents. The presentation includes data on natural climate change, temperature anomaly, the ice in the Arctic Ocean and Northern and Southern Hemisphere sea ice area, current in Southern and Northern hemisphere sea ice area and variations of the surface temperature ice arctic regions antarctic regions. The presentation was held at the MNT-Forum, 29. January 2008

  4. Hanford Tanks Initiative fiscal year 1997 retrieval technology demonstrations

    International Nuclear Information System (INIS)

    Berglin, E.J.

    1998-01-01

    The Hanford Tanks Initiative was established in 1996 to address a range of retrieval and closure issues associated with radioactive and hazardous waste stored in Hanford's single shell tanks (SSTs). One of HTI's retrieval goals is to ''Successfully demonstrate technology(s) that provide expanded capabilities beyond past practice sluicing and are extensible to retrieve waste from other SSTS.'' Specifically, HTI is to address ''Alternative technologies to past practice sluicing'' ... that can ... ''successfully remove the hard heel from a sluiced tank or to remove waste from a leaking SST'' (HTI Mission Analysis). During fiscal year 1997, the project contracted with seven commercial vendor teams to demonstrate retrieval technologies using waste simulants. These tests were conducted in two series: three integrated tests (IT) were completed in January 1997, and four more comprehensive Alternative Technology Retrieval Demonstrations (ARTD) were completed in July 1997. The goal of this testing was to address issues to minimize the risk, uncertainties, and ultimately the overall cost of removing waste from the SSTS. Retrieval technologies can be separated into three tracks based on how the tools would be deployed in the tank: globally (e.g., sluicing) or using vehicles or robotic manipulators. Accordingly, the HTI tests included an advanced sluicer (Track 1: global systems), two different vehicles (Track 2: vehicle based systems), and three unique manipulators (Track 3: arm-based systems), each deploying a wide range of dislodging tools and conveyance systems. Each industry team produced a system description as envisioned for actual retrieval and a list of issues that could prevent using the described system; defined the tests to resolve the issues; performed the test; and reported the results, lessons learned, and state of issue resolution. These test reports are cited in this document, listed in the reference section, and summarized in the appendices. This report

  5. Hanford Tanks Initiative fiscal year 1997 retrieval technology demonstrations

    Energy Technology Data Exchange (ETDEWEB)

    Berglin, E.J.

    1998-02-05

    The Hanford Tanks Initiative was established in 1996 to address a range of retrieval and closure issues associated with radioactive and hazardous waste stored in Hanford`s single shell tanks (SSTs). One of HTI`s retrieval goals is to ``Successfully demonstrate technology(s) that provide expanded capabilities beyond past practice sluicing and are extensible to retrieve waste from other SSTS.`` Specifically, HTI is to address ``Alternative technologies to past practice sluicing`` ... that can ... ``successfully remove the hard heel from a sluiced tank or to remove waste from a leaking SST`` (HTI Mission Analysis). During fiscal year 1997, the project contracted with seven commercial vendor teams to demonstrate retrieval technologies using waste simulants. These tests were conducted in two series: three integrated tests (IT) were completed in January 1997, and four more comprehensive Alternative Technology Retrieval Demonstrations (ARTD) were completed in July 1997. The goal of this testing was to address issues to minimize the risk, uncertainties, and ultimately the overall cost of removing waste from the SSTS. Retrieval technologies can be separated into three tracks based on how the tools would be deployed in the tank: globally (e.g., sluicing) or using vehicles or robotic manipulators. Accordingly, the HTI tests included an advanced sluicer (Track 1: global systems), two different vehicles (Track 2: vehicle based systems), and three unique manipulators (Track 3: arm-based systems), each deploying a wide range of dislodging tools and conveyance systems. Each industry team produced a system description as envisioned for actual retrieval and a list of issues that could prevent using the described system; defined the tests to resolve the issues; performed the test; and reported the results, lessons learned, and state of issue resolution. These test reports are cited in this document, listed in the reference section, and summarized in the appendices. This report

  6. Arctic microbial ecosystems and impacts of extreme warming during the International Polar Year

    Science.gov (United States)

    Vincent, Warwick F.; Whyte, Lyle G.; Lovejoy, Connie; Greer, Charles W.; Laurion, Isabelle; Suttle, Curtis A.; Corbeil, Jacques; Mueller, Derek R.

    2009-11-01

    As a contribution to the International Polar Year program MERGE (Microbiological and Ecological Responses to Global Environmental change in polar regions), studies were conducted on the terrestrial and aquatic microbial ecosystems of northern Canada (details at: http://www.cen.ulaval.ca/merge/). The habitats included permafrost soils, saline coldwater springs, supraglacial lakes on ice shelves, epishelf lakes in fjords, deep meromictic lakes, and shallow lakes, ponds and streams. Microbiological samples from each habitat were analysed by HPLC pigment assays, light and fluorescence microscopy, and DNA sequencing. The results show a remarkably diverse microflora of viruses, Archaea (including ammonium oxidisers and methanotrophs), Bacteria (including filamentous sulfur-oxidisers in a saline spring and benthic mats of Cyanobacteria in many waterbodies), and protists (including microbial eukaryotes in snowbanks and ciliates in ice-dammed lakes). In summer 2008, we recorded extreme warming at Ward Hunt Island and vicinity, the northern limit of the Canadian high Arctic, with air temperatures up to 20.5 °C. This was accompanied by pronounced changes in microbial habitats: deepening of the permafrost active layer; loss of perennial lake ice and sea ice; loss of ice-dammed freshwater lakes; and 23% loss of total ice shelf area, including complete break-up and loss of the Markham Ice Shelf cryo-ecosystem. These observations underscore the vulnerability of Arctic microbial ecosystems to ongoing climate change.

  7. The Amphibian Research and Monitoring Initiative (ARMI): 5-year report

    Science.gov (United States)

    Muths, Erin; Gallant, Alisa L.; Campbell Grant, Evan H.; Battaglin, William A.; Green, David E.; Staiger, Jennifer S.; Walls, Susan C.; Gunzburger, Margaret S.; Kearney, Rick F.

    2006-01-01

    The Amphibian Research and Monitoring Initiative (ARMI) is an innovative, multidisciplinary program that began in 2000 in response to a congressional directive for the Department of the Interior to address the issue of amphibian declines in the United States. ARMI’s formulation was cross-disciplinary, integrating U.S. Geological Survey scientists from Biology, Water, and Geography to develop a course of action (Corn and others, 2005a). The result has been an effective program with diverse, yet complementary, expertise.

  8. 76 FR 55403 - Announcement of Funding Awards for Fiscal Year 2010 Transformation Initiative: Sustainable...

    Science.gov (United States)

    2011-09-07

    ... Awards for Fiscal Year 2010 Transformation Initiative: Sustainable Communities Research Grant (SCRGP... Fiscal Year (FY) 2010 Transformative Initiative: Sustainable Communities Research Grant Program (SCRGP...&R), under the Assistant Secretary, administered the FY10 Sustainable Communities Research Grant...

  9. Spatio-temporal variability of the polar middle atmosphere. Insights from over 30 years of research satellite observations

    Energy Technology Data Exchange (ETDEWEB)

    Lahoz, W.A.; Orsolini, Y.J.; Manney, G.L.; Minschwaner, K.; Allen, D.R.; Errera, Q.; Jackson, D.R.; Lambert, A.; Lee, J.; Pumphrey, H.; Schwartz, M.; Wu, D.

    2012-07-01

    We discuss the insights that research satellite observations from the last 30 years have provided on the spatio-temporal variability of the polar middle atmosphere. Starting from the time of the NASA LIMS (Limb Infrared Monitor of the Stratosphere) and TOMS (Total Ozone Mapping Spectrometer) instruments, both launched in 1978, we show how these observations have augmented our knowledge of the polar middle atmosphere, in particular how information on ozone and tracers has augmented our knowledge of: (i) the spatial and temporal characteristics of the wintertime polar stratosphere and the summertime circulation; and (ii) the roles of chemistry and transport in determining the stratospheric ozone distribution. We address the increasing joint use of observations and models, in particular in data assimilation, in contributing to this understanding. Finally, we outline requirements to allow continuation of the wealth of information on the polar middle atmosphere provided by research satellites over the last 30 years.(Author)

  10. Gravity with free initial conditions: A solution to the cosmological constant problem testable by CMB B -mode polarization

    Science.gov (United States)

    Totani, Tomonori

    2017-10-01

    In standard general relativity the universe cannot be started with arbitrary initial conditions, because four of the ten components of the Einstein's field equations (EFE) are constraints on initial conditions. In the previous work it was proposed to extend the gravity theory to allow free initial conditions, with a motivation to solve the cosmological constant problem. This was done by setting four constraints on metric variations in the action principle, which is reasonable because the gravity's physical degrees of freedom are at most six. However, there are two problems about this theory; the three constraints in addition to the unimodular condition were introduced without clear physical meanings, and the flat Minkowski spacetime is unstable against perturbations. Here a new set of gravitational field equations is derived by replacing the three constraints with new ones requiring that geodesic paths remain geodesic against metric variations. The instability problem is then naturally solved. Implications for the cosmological constant Λ are unchanged; the theory converges into EFE with nonzero Λ by inflation, but Λ varies on scales much larger than the present Hubble horizon. Then galaxies are formed only in small Λ regions, and the cosmological constant problem is solved by the anthropic argument. Because of the increased degrees of freedom in metric dynamics, the theory predicts new non-oscillatory modes of metric anisotropy generated by quantum fluctuation during inflation, and CMB B -mode polarization would be observed differently from the standard predictions by general relativity.

  11. Science Communication during the International Polar Year 2007-2008: Successes and Recommendations (Invited)

    Science.gov (United States)

    Carlson, D. J.; Ipy Education, Outreach; Communication Committee

    2010-12-01

    This IPY (International Polar Year 2007-2008) represented one of the largest international scientific research efforts ever undertaken. It stimulated the active engagement of thousands of teachers, students, and citizens around the globe through international collaboration and cooperation, careful cultivation of a global community of enthusiastic professional science communicators and educators, and creative use of free technologies. From music performances in Alaska to tree planting in Malaysia, hundreds of events and activities around the world demonstrated the public enthusiasm and the broad impact of IPY. This paper describes the core concepts and tangible activities developed and implemented by the IPY international Education, Outreach, and Communication (EOC) Committee and community and the International Programme Office (IPO) between March 2006 and December 2009. We present methods and accomplishments and address two questions: 1) How did these activities come about? 2) How do the ideas, tools, experiences, and successes from this IPY apply more broadly to science communication?

  12. Special wasteform lysimeters initial three-year monitoring report

    International Nuclear Information System (INIS)

    Oblath, S.B.; Grant, M.W.

    1985-01-01

    Lysimeters containing ten typical commercial power reactor low-level wsteforms are in operation at the Savannah River Plant. This ten-year program is designed to measure the leaching and migration of radionuclides from these wasteforms under realistic burial ground conditions in a humid site. The data which the lysimeters provide serves as a technical basis for evaluating the performance of the wasteforms under actual burial conditions. Three years' operation of the lysimeters has demonstrated that all of the wasteforms perform excellently, with minimal releases of radioactivity. Cement-based wasteforms appear superior at retaining strontium. Polymer-based wasteforms appear superior at retaining cobalt and cesium isotopes. The releases of activity from the lysimeters are compared to the leaching behavior in immersion tests, with several differences noted. The conclusions drawn in this study are tentative, subject to the performance of the wasteforms after the lysimeters have been in operation for a longer period of time

  13. Complications in paediatric craniofacial surgery: an initial four year experience.

    Science.gov (United States)

    Jones, B M; Jani, P; Bingham, R M; Mackersie, A M; Hayward, R

    1992-04-01

    107 children undergoing transcranial craniofacial surgery in a paediatric hospital have been reviewed to assess the incidence and type of complications which arose. This represents the first 4 years' experience of the craniofacial team. There were no deaths or permanent adverse sequelae of surgery. A total of 53 complications were seen in 42 patients. In 9.3% of patients they were potentially life-threatening, serious in 12.1% and of a minor nature in 28%. The more serious complications were related either to haemorrhage and/or vasovagal shock at operation or to infection post-operatively. Infants undergoing monoblock frontofacial advancements and those with tracheostomies were at particular risk.

  14. Advances in seismic monitoring at Deception Island volcano (Antarctica since the International Polar Year

    Directory of Open Access Journals (Sweden)

    Enrique Carmona

    2014-06-01

    Full Text Available Deception Island is an active volcano located in the south Shetland Islands, Antarctica. It constitutes a natural laboratory to test geophysical instruments in extreme conditions, since they have to endure not only the Antarctic climate but also the volcanic environment. Deception is one of the most visited places in Antarctica, both by scientists and tourists, which emphasize the importance of volcano monitoring. Seismic monitoring has been going on since 1986 during austral summer surveys. The recorded data include volcano-tectonic earthquakes, long-period events and volcanic tremor, among others. The level of seismicity ranges from quiet periods to seismic crises (e.g. 1992-1993, 1999. Our group has been involved in volcano monitoring at Deception Island since 1994. Based on this experience, in recent years we have made the most of the opportunities of the International Polar Year 2007-2008 to introduce advances in seismic monitoring along four lines: (1 the improvement of the seismic network installed for seismic monitoring during the summer surveys; (2 the development and improvement of seismic arrays for the detection and characterization of seismo-volcanic signals; (3 the design of automated event recognition tools, to simplify the process of data interpretation; and (4 the deployment of permanent seismic stations. These advances help us to obtain more data of better quality, and therefore to improve our interpretation of the seismo-volcanic activity at Deception Island, which is a crucial step in terms of hazards assessment.

  15. Constraining the regular Galactic magnetic field with the 5-year WMAP polarization measurements at 22 GHz

    Science.gov (United States)

    Ruiz-Granados, B.; Rubiño-Martín, J. A.; Battaner, E.

    2010-11-01

    Context. The knowledge of the regular (large scale) component of the Galactic magnetic field gives important information about the structure and dynamics of the Milky Way, and also constitutes a basic tool to determine cosmic ray trajectories. It can also provide clear windows where primordial magnetic fields could be detected. Aims: We aim to obtain the regular (large scale) pattern of the magnetic field distribution of the Milky Way that better fits the polarized synchrotron emission as seen by the WMAP satellite in the 5 years data at 22 GHz. Methods: We have done a systematic study of a number of Galactic magnetic field models: axisymmetric (with and without radial dependence on the field strength), bisymmetric (with and without radial dependence), logarithmic spiral arms, concentric circular rings with reversals and bi-toroidal. We have explored the parameter space defining each of these models using a grid-based approach. In total, more than one million models were computed. The model selection was done using a Bayesian approach. For each model, the posterior distributions were obtained and marginalized over the unwanted parameters to obtain the marginal (one-parameter) probability distribution functions. Results: In general, axisymmetric models provide a better description of the halo component, although with regard to their goodness-of-fit, the other models cannot be rejected. In the case of the disk component, the analysis is not very sensitive for obtaining the disk large-scale structure, because of the effective available area (less than 8% of the whole map and less than 40% of the disk). Nevertheless, within a given family of models, the best-fit parameters are compatible with those found in the literature. Conclusions: The family of models that better describes the polarized synchrotron halo emission is the axisymmetric one, with magnetic spiral arms with a pitch angle of ≈24°, and a strong vertical field of 1 μG at z ≈ 1 kpc. When a radial

  16. Crew and Thermal Systems Division Strategic Communications Initiatives in Support of NASA's Strategic Goals: Fiscal Year 2012 Summary and Initial Fiscal Year 2013 Metrics

    Science.gov (United States)

    Paul, Heather L.

    2013-01-01

    The NASA strategic plan includes overarching strategies to inspire students through interactions with NASA people and projects, and to expand partnerships with industry and academia around the world. The NASA Johnson Space Center Crew and Thermal Systems Division (CTSD) actively supports these NASA initiatives. At the end of fiscal year 2011, CTSD created a strategic communications team to communicate CTSD capabilities, technologies, and personnel to internal NASA and external technical audiences for collaborative and business development initiatives, and to students, educators, and the general public for education and public outreach efforts. The strategic communications initiatives implemented in fiscal year 2012 resulted in 707 in-reach, outreach, and commercialization events with 39,731 participant interactions. This paper summarizes the CTSD Strategic Communications metrics for fiscal year 2012 and provides metrics for the first nine months of fiscal year 2013.

  17. In vitro Th1 and Th2 cell polarization is severely influenced by the initial ratio of naïve and memory CD4+ T cells

    DEFF Research Database (Denmark)

    Blom, Lars; Poulsen, Lars K.

    2013-01-01

    Robust in vitro systems are important in elucidating mechanisms regarding the heterogenetic nature of in vivo immune responses and contribute with knowledge to design good in vivo experiments. In this study, we show that initial Th1 and in particular Th2 polarization was negatively influenced by ...

  18. Power Polarity In The Far Eastern World System, 1025 BC–AD 1850: Narrative And 25-Year Interval Data

    Directory of Open Access Journals (Sweden)

    David Wikinson

    2015-08-01

    Full Text Available Power polarity in the Far Eastern macro-social system is assessed at twenty five year intervals 1050 BC-AD 1850. Consistent with analysis of Indic system data, there is no support for the theory that the normal world-system power configuration is multipolar, hegemonic, or universal-empire. Instead several different "stability epochs" are discerned.

  19. Characterization of polarity development through 2- and 3-D imaging during the initial phase of microspore embryogenesis in Brassica napus L.

    Science.gov (United States)

    Dubas, Ewa; Custers, Jan; Kieft, Henk; Wędzony, Maria; van Lammeren, André A M

    2014-01-01

    Isolated microspores of B. napus in culture change their developmental pathway from gametophytic to sporophytic and form embryo-like structures (ELS) upon prolonged heat shock treatment (5 days at 32 °C). ELS express polarity during the initial days of endosporic development. In this study, we focussed on the analysis of polarity development of ELS without suspensor. Fluorescence microscopy and 3-D confocal laser scanning microscopy (CLSM) without tissue interfering enabled us to get a good insight in the distribution of nuclei, mitochondria and endoplasmic reticulum (ER), the architecture of microtubular (MT) cytoskeleton and the places of 5-bromo-2'-deoxy-uridine (BrdU) incorporation in successive stages of microspore embryogenesis. Scanning electron microscopy (SEM) analysis revealed, for the first time, the appearance of a fibrillar extracellular matrix-like structure (ECM-like structure) in androgenic embryos without suspensor. Two types of endosporic development were distinguished based upon the initial location of the microspore nucleus. The polarity of dividing and growing cells was recognized by the differential distributions of organelles, by the organization of the MT cytoskeleton and by the visualization of DNA synthesis in the cell cycle. The directional location of nuclei, ER, mitochondria and starch grains in relation to the MTs configurations were early polarity indicators. Both exine rupture and ECM-like structure on the outer surfaces of ELS are supposed to stabilize ELS's morphological polarity. As the role of cell polarity during early endosporic microspore embryogenesis in apical-basal cell fate determination remains unclear, microspore culture system provides a powerful in vitro tool for studying the developmental processes that take place during the earliest stages of plant embryogenesis.

  20. Long-distance swimming by polar bears (Ursus maritimus) of the southern Beaufort Sea during years of extensive open water

    Science.gov (United States)

    2014-01-01

    Polar bears (Ursus maritimus Phipps, 1774) depend on sea ice for catching marine mammal prey. Recent sea-ice declines have been linked to reductions in body condition, survival, and population size. Reduced foraging opportunity is hypothesized to be the primary cause of sea-ice-linked declines, but the costs of travel through a deteriorated sea-ice environment also may be a factor. We used movement data from 52 adult female polar bears wearing Global Positioning System (GPS) collars, including some with dependent young, to document long-distance swimming (>50 km) by polar bears in the southern Beaufort and Chukchi seas. During 6 years (2004-2009), we identified 50 long-distance swims by 20 bears. Swim duration and distance ranged from 0.7 to 9.7 days (mean = 3.4 days) and 53.7 to 687.1 km (mean = 154.2 km), respectively. Frequency of swimming appeared to increase over the course of the study. We show that adult female polar bears and their cubs are capable of swimming long distances during periods when extensive areas of open water are present. However, long-distance swimming appears to have higher energetic demands than moving over sea ice. Our observations suggest long-distance swimming is a behavioral response to declining summer sea-ice conditions.

  1. The Initial Conceptions for Earthquakes Phenomenon for Moroccan Students of the First Year Secondary College

    Science.gov (United States)

    Eddif, Aâtika; Touir, Rachid; Majdoubi, Hassan; Larhzil, Hayat; Mousaoui, Brahim; Ahmamou, Mhamed

    2015-01-01

    This work proposes initially to identify the initial conceptions of Moroccan students in the first year of secondary college about the notion of earthquakes. The used methodology is based on a questionnaire addressed to students of life science and Earth in Meknes city, before any official teaching about the said phenomenon. The obtained results…

  2. Deep Vadose Zone–Applied Field Research Initiative Fiscal Year 2012 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    Wellman, Dawn M.; Truex, Michael J.; Johnson, Timothy C.; Bunn, Amoret L.; Golovich, Elizabeth C.

    2013-03-14

    This annual report describes the background of the Deep Vadose Zone-Applied Field Research Initiative, and some of the programmatic approaches and transformational technologies in groundwater and deep vadose zone remediation developed during fiscal year 2012.

  3. Dynamics and Morphology of Saturn’s North Polar Region During Cassini’s Final Year

    Science.gov (United States)

    Blalock, John J.; Sayanagi, Kunio M.; Ingersoll, Andrew P.; Dyudina, Ulyana A.; Ewald, Shawn; McCabe, Ryan M.; Gunnarson, Jacob; Garland, Justin; Gallego, Angelina

    2017-10-01

    We present an analysis of Saturn’s north polar region utilizing Cassini ISS images captured in visible and near-infrared wavelengths during late 2016 and 2017, including images captured during Cassini’s Grand Finale orbits. To measure the wind field in the region, we utilize the two-dimensional correlation imaging velocimetry (CIV) technique. We also calculate the relative vorticity and divergence from the wind field. To detect changes in the dynamics, we compare measurements of the wind, relative vorticity, and divergence in 2012 and 2013 with those from 2016/2017. We also compare cloud reflectivity between 2012/2013 and 2016/2017 in images that show the north pole under similar illumination conditions. To detect changes in cloud reflectivity, we utilize a Minnaert correction to calculate the zonal mean reflectivity as a function of latitude. Furthermore, we compare the winds and cloud reflectivity at several wavelengths in order to look for changes occurring at different altitudes. Our results indicate that while the dynamics of the north polar region have remained relatively stable, there have been significant morphology changes that have resulted in dramatic color changes. We hypothesize that these changes are a result of the seasonal cycle and linked to the increased production of photochemical hazes in the atmosphere. Our work has been supported by NASA PATM NNX14AK07G, NSF AAG 1212216, and NASA NESSF NNX15AQ70H.

  4. Regulation of cell polarity by cell adhesion receptors.

    Science.gov (United States)

    Ebnet, Klaus; Kummer, Daniel; Steinbacher, Tim; Singh, Amrita; Nakayama, Masanori; Matis, Maja

    2017-07-22

    The ability of cells to polarize is an intrinsic property of almost all cells and is required for the devlopment of most multicellular organisms. To develop cell polarity, cells integrate various signals derived from intrinsic as well as extrinsic sources. In the recent years, cell-cell adhesion receptors have turned out as important regulators of cellular polarization. By interacting with conserved cell polarity proteins, they regulate the recruitment of polarity complexes to specific sites of cell-cell adhesion. By initiating intracellular signaling cascades at those sites, they trigger their specific subcellular activation. Not surprisingly, cell-cell adhesion receptors regulate diverse aspects of cell polarity, including apico-basal polarity in epithelial and endothelial cells, front-to-rear polarity in collectively migrating cells, and planar cell polarity during organ development. Here, we review the recent developments highlighting the central roles of cell-cell adhesion molecules in the development of cell polarity. Copyright © 2017 Elsevier Ltd. All rights reserved.

  5. Integrating Access to Arctic Environmental Change and Human Health Research for the International Polar Year and Beyond

    Science.gov (United States)

    Garrett, C. L.

    2006-12-01

    hosting the Arctic Human Health Initiative (AHHI), the human health focus of the International Polar Year activities. AHHI will coordinate research in the areas of infectious disease; the effects of anthropogenic pollution, UV radiation, and climate variability on human health; and telehealth innovations. A major goal of AHHI is the better integration of the findings of Arctic health research through outreach programs and public education.

  6. Polarization holography

    DEFF Research Database (Denmark)

    Nikolova, L.; Ramanujam, P.S.

    Current research into holography is concerned with applications in optically storing, retrieving, and processing information. Polarization holography has many unique properties compared to conventional holography. It gives results in high efficiency, achromaticity, and special polarization...... properties. This books reviews the research carried out in this field over the last 15 years. The authors provide basic concepts in polarization and the propagation of light through anisotropic materials, before presenting a sound theoretical basis for polarization holography. The fabrication...... and characterization of azobenzene based materials, which remain the most efficient for the purpose, is described in detail. This is followed by a description of other materials that are used in polarization holography. An in-depth description of various applications, including display holography and optical storage...

  7. The Thermal State of Permafrost in the Nordic Area during the International Polar Year 2007-2009

    DEFF Research Database (Denmark)

    Christiansen, H. H.; Etzelmuller, B.; Isaksen, K.

    2010-01-01

    This paper provides a snapshot of the permafrost thermal state in the Nordic area obtained during the International Polar Year (IPY) 2007-2009. Several intensive research campaigns were undertaken within a variety of projects in the Nordic countries to obtain this snapshot. We demonstrate...... of the Nordic area, the permafrost is somewhat colder, but still only a few degrees below the freezing point. The observations presented from the network of boreholes, more than half of which were established during the IPY, provide an important baseline to assess how future predicted climatic changes may...

  8. Recidivism among Child Sexual Abusers: Initial Results of a 13-Year Longitudinal Random Sample

    Science.gov (United States)

    Patrick, Steven; Marsh, Robert

    2009-01-01

    In the initial analysis of data from a random sample of all those charged with child sexual abuse in Idaho over a 13-year period, only one predictive variable was found that related to recidivism of those convicted. Variables such as ethnicity, relationship, gender, and age differences did not show a significant or even large association with…

  9. Examining Student Digital Artifacts during a Year-Long Technology Integration Initiative

    Science.gov (United States)

    Rodriguez, Prisca M.; Frey, Chris; Dawson, Kara; Liu, Feng; Ritzhaupt, Albert D.

    2012-01-01

    This study was situated within a year-long, statewide technology integration initiative designed to support technology integration within science, technology, engineering, and math classrooms. It examined the elements used in student artifacts in an attempt to investigate trends in digital artifact creation. Among several conclusions, this…

  10. Growth and yield predictions for upland oak stands. 10 years after initial thinning

    Science.gov (United States)

    Martin E. Dale; Martin E. Dale

    1972-01-01

    The purpose of this paper is to furnish part of the needed information, that is, quantitative estimates of growth and yield 10 years after initial thinning of upland oak stands. All estimates are computed from a system of equations. These predictions are presented here in tabular form for convenient visual inspection of growth and yield trends. The tables show growth...

  11. Prevalence of marijuana use at college entry and risk factors for initiation during freshman year.

    Science.gov (United States)

    Suerken, Cynthia K; Reboussin, Beth A; Sutfin, Erin L; Wagoner, Kimberly G; Spangler, John; Wolfson, Mark

    2014-01-01

    Marijuana is currently the most commonly used drug on college campuses. Marijuana use among college students is increasing, and many students begin using marijuana during college. The goal of this study was to investigate predictors of lifetime marijuana use at college entry and initiation during freshman year. We used responses from the first two semesters of a longitudinal study of 3146 students from 11 colleges in North Carolina and Virginia. Random-effects logistic regression models were constructed to identify factors that predict lifetime marijuana use at college entry and initiation during freshman year. Nearly 30% of students reported ever having used marijuana at college entry. Among students who had never used marijuana prior to college, 8.5% initiated use during freshman year. In multivariable logistic regression models, having at least $100 per month in spending money; attending church rarely or never; current use of cigarettes, alcohol, and hookah tobacco; lifetime use of other illicit drugs; and a higher propensity toward sensation seeking were associated with a higher likelihood of having used marijuana at least once at college entry. Hispanic ethnicity, living on campus, and current use of cigarettes and alcohol were associated with a higher likelihood of initiating marijuana use during freshman year. These results have implications for targeting substance abuse prevention programs on college campuses.

  12. Links to Learning and Sustainability: Year Three Report of the Pennsylvania High School Coaching Initiative

    Science.gov (United States)

    Brown, Diane; Reumann-Moore, Rebecca; Hugh, Roseann; Christman, Jolley Bruce; Riffer, Morgan

    2009-01-01

    Research for Action's third and final report completes a three-year evaluation study of the Pennsylvania High School Coaching Initiative (PAHSCI). This report presents lessons from the PAHSCI model of school-based instructional coaching and mentoring as a vehicle for job-embedded professional learning. Reporting from an analysis using qualitative…

  13. [Pulmonary Metastasis from a Phyllodes Tumor of the Breast Developing Sixteen Years after Initial Surgery].

    Science.gov (United States)

    Chang, Sung-Soo; Nakano, Takayuki; Okamoto, Taku; Takabatake, Daisuke

    2015-11-01

    We report a case of solitary pulmonary metastasis from a phyllodes tumor of the breast appearing 16 years after initial surgery. The patient was a 56-year-old woman who had undergone surgical extirpation of a left breast tumor diagnosed as phyllodes tumor (borderline malignancy) in 1998, and a right breast tumor diagnosed as fibromatosis in 2000. Sixteen years after the initial operation, she consulted our hospital because of a chest X-ray abnormality detected at a screening examination. Chest computed tomography revealed a well defined nodular shadow in the left upper lobe of the lung. Surgery was done since primary lung cancer was suspected. However, pathological diagnosis was a pulmonary metastasis from the phyllodes tumor of the left breast. Right breast tumor was also diagnosed as a metastasis from the left breast tumor by histopathological re-evaluation.

  14. Effect of light source parameters on the polarization properties of the beam

    Science.gov (United States)

    Liu, Dan; Liu, Yan; Jiang, Hui-lin; Liu, Zhi; Zhou, Xin; Fang, Hanhan

    2013-08-01

    Polarized laser has been widely used in free space optical communication, laser radar, and laser ranging system because of its advantages of good performance in recent years. The changes of laser polarization properties in the process of transmission in atmospheric turbulence have a certain impact on the system performance. The paper research on the rule of polarization properties changes of Gauss Schell model beam in turbulent conditions. And analysis the main factors to affect the polarization properties by numerical simulation using MATLAB software tools. The factors mainly including: initial polarization, coherence coefficient, spot size and the intensity of the atmospheric turbulent. The simulation results show that, the degree of polarization will converge to the initial polarization when the beam propagation in turbulent conditions. The degrees of polarization change to different value when initial polarization of beam is different in a short distance. And, the degrees of polarization converge to the initial polarization after long distance. Beam coherence coefficient bigger, the degree of polarization and change range increases bigger. The change of polarization more slowly for spot size is bigger. The change of polarization change is faster for longer wavelength. The conclusion of the study indicated that the light source parameters effect the changes of polarization properties under turbulent conditions. The research provides theory basis for the polarization properties of the laser propagation, and it will plays a significant role in optical communication and target recognition.

  15. Factors predicting Behavior Management Problems during Initial Dental Examination in Children Aged 2 to 8 Years

    OpenAIRE

    Sharma, Arun; Kumar, Dipanshu; Anand, Ashish; Mittal, Vipula; Singh, Aparna; Aggarwal, Nidhi

    2017-01-01

    Aim The aim of the present study was to identify the various background variables and its influence on behavior management problems (BMP) in children. Materials and methods The study included 165 children aged 2 to 8 years. During the initial dental visit, an experienced operator obtained each child?s background variables from accompanying guardians using a standardized questionnaire. Children?s dental behavior was rated by Frankel behavior rating scale. The behavior was then analyzed in rela...

  16. Fiscal Year 2014 Annual Report on BNLs Next Generation Safeguards Initiative Human Capital Development Activities

    Energy Technology Data Exchange (ETDEWEB)

    Pepper, Susan E. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2014-10-10

    Brookhaven National Laboratory’s (BNL’s) Nonproliferation and National Security Department contributes to the National Nuclear Security Administration Office of Nonproliferation and International Security Next Generation Safeguards Initiative (NGSI) through university engagement, safeguards internships, safeguards courses, professional development, recruitment, and other activities aimed at ensuring the next generation of international safeguards professionals is adequately prepared to support the U.S. safeguards mission. This report is a summary of BNL s work under the NGSI program in Fiscal Year 2014.

  17. Bouncing continents: insights into the physics of the polar regions of the Earth from the POLENET project in the International Polar Year

    International Nuclear Information System (INIS)

    Reading, Anya M

    2008-01-01

    When ice sheets melt, and reduce the load on the surface of the Earth, the land areas beneath them bounce back up. New, accurate observations are needed to investigate this uplift and its implications effectively. This article provides a topical starting point for investigating some applications of physics applied to the polar regions of the Earth, and interaction between the solid Earth, ice and oceans

  18. Enhancing the Environmental Legacy of the International Polar Year 2007- 2008

    Science.gov (United States)

    Tin, T.; Roura, R.; Perrault, M.

    2006-12-01

    The International Geophysical Year (IGY) left a legacy of peace and international cooperation in the form of the 1959 Antarctic Treaty. Since the IGY, the 1991 Protocol of Environmental Protection to the Antarctic Treaty was signed and entered into force. The Protocol establishes that the protection of the environment and the wilderness values of Antarctica "shall be fundamental considerations in the planning and conduct of all activities in the Antarctic Treaty area". Fifty years on, the IPY 2007-08 can, in turn, leave behind a positive environmental legacy - where the sharing of facilities and logistics are encouraged, the human footprint in Antarctica is minimized and a future generation of environmentally aware scientists, logisticians and visitors is fostered. Based on an analysis of all Expressions of Interest submitted to the IPY, we found that about three-quarters of IPY's Antarctic projects plan to have fieldwork components. About one-third of these field projects expect to leave physical infrastructure in Antarctica. A number of projects plan to develop large-scale infrastructure, such as stations and observatories, in hitherto pristine areas. Fewer than one percent of Antarctic field projects address the issue of their environmental legacy: four projects indicated that the site will be cleaned up or the equipment will be removed at the end of the project; two projects indicated that their results may be useful for the management of the Antarctic environment, e.g., in the control of invasive species or setting up of marine protected areas. With the goal of increasing the environmental awareness of Antarctic field scientists, our contribution will review current research on the impacts of human activities science, tourism, exploitation of marine resources and global climate change - on the Antarctic environment. A preliminary analysis of the cumulative impacts of IPY activities will be presented. Case studies of scientific projects in Antarctica with a

  19. 42 CFR 68a.11 - How does an individual receive loan repayments beyond the initial two-year contract?

    Science.gov (United States)

    2010-10-01

    ... beyond the initial two-year contract? 68a.11 Section 68a.11 Public Health PUBLIC HEALTH SERVICE... How does an individual receive loan repayments beyond the initial two-year contract? An individual may apply for and the Secretary may grant extension contracts for one-year periods, if there is sufficient...

  20. 42 CFR 68c.11 - How does an individual receive loan repayments beyond the initial two-year contract?

    Science.gov (United States)

    2010-10-01

    ... beyond the initial two-year contract? 68c.11 Section 68c.11 Public Health PUBLIC HEALTH SERVICE... an individual receive loan repayments beyond the initial two-year contract? An individual may apply for and the Secretary may grant extension contracts for one-year periods, if there is sufficient debt...

  1. Twelve-year mortality in adults initiating antiretroviral therapy in South Africa.

    Science.gov (United States)

    Cornell, Morna; Johnson, Leigh F; Wood, Robin; Tanser, Frank; Fox, Matthew P; Prozesky, Hans; Schomaker, Michael; Egger, Matthias; Davies, Mary-Ann; Boulle, Andrew

    2017-09-25

    South Africa has the largest number of individuals living with HIV and the largest antiretroviral therapy (ART) programme worldwide. In September 2016, ART eligibility was extended to all 7.1 million HIV-positive South Africans. To ensure that further expansion of services does not compromise quality of care, long-term outcomes must be monitored. Few studies have reported long-term mortality in resource-constrained settings, where mortality ascertainment is challenging. Combining site records with data linked to the national vital registration system, sites in the International Epidemiology Databases to Evaluate AIDS Southern Africa collaboration can identify >95% of deaths in patients with civil identification numbers (IDs). This study used linked data to explore long-term mortality and viral suppression among adults starting ART in South Africa. The study was a cohort analysis of routine data on adults with IDs starting ART 2004-2015 in five large ART cohorts. Mortality was estimated overall and by gender using the Kaplan-Meier estimator and Cox's proportional hazards regression. Standardized mortality ratios (SMRs) were calculated by dividing observed numbers of deaths by numbers expected if patients had been HIV-negative. Viral suppression in patients with viral loads (VLs) in their last year of follow-up was the secondary outcome. Among 72,812 adults followed for 350,376 person years (pyrs), the crude mortality rate was 3.08 (95% CI 3.02-3.14)/100 pyrs. Patients were predominantly female (67%) and the percentage of men initiating ART did not increase. Cumulative mortality 12 years after ART initiation was 23.9% (33.4% male and 19.4% female). Mortality peaked in patients enrolling in 2007-2009 and was higher in men than women at all durations. Observed mortality rates were higher than HIV-negative mortality, decreasing with duration. By 48 months, observed mortality was close to that in the HIV-negative population, and SMRs were similar for all baseline CD4

  2. Initial 10-year Experience of Sperm Cryopreservation Services for Cancer Patients

    Directory of Open Access Journals (Sweden)

    Hong-Chiang Chang

    2006-01-01

    Full Text Available Offering sperm cryopreservation to preserve the fertility of male cancer patients is a relatively recent service in Asia. This study analyzed the types of cancer, timing of collection, sperm quality, and utilization for reproductive services by patients during a 10-year period at a medical center in Taiwan. A total of 75 oncology patients elected to freeze sperm for fertility preservation at our medical center during the initial 10 years of the availability of this service. The mean age of the patients was 25.7 years. Storage was discontinued in 13 (17% patients and their survival duration was 13.1 ±11.1 months. The utilization rate of sperm cryo-preservation was 2.8% (75/2642. The types of cancer varied, with leukemia (35%, lymphoma (25%, and testicular cancer (13% comprising the largest groups. A significantly lower sperm count was found in patients with chronic myelogenous leukemia, suggesting the need for earlier sperm collection after initiation of cancer treatment. Only three (4% patients utilized their specimens for reproductive purposes. There was no clinical pregnancy during the study period, although one biochemical pregnancy was achieved. The low rates of sperm cryostorage for fertility preservation in cancer patients in this study suggest that there is a need for greater emphasis of this option for male oncology patients whose fertility is likely to be affected by chemotherapeutic treatment.

  3. A Qualitative Study of the Context of Child and Adolescent Substance Use Initiation and Patterns of Use in the First Year for Early and Later Initiators.

    Directory of Open Access Journals (Sweden)

    Sharon Kingston

    Full Text Available Individuals who initiate substance use before high school are at higher risk of negative outcomes. Eighty-six young adults between the ages of 18 and 28 participated in semi-structured qualitative interviews focused on the circumstances surrounding participants' first use of substances and their pattern of use in the year following initiation in order to investigate similarities and differences between early versus later initiators. Initiation and use among early initiators were more likely to be encouraged by poor parental monitoring or active facilitation of use by parents. Early initiators were more likely to report risky patterns of use such as daily use and using alone. The data suggest that interventions targeting this population should focus on improving parental monitoring and decreasing positive parental attitudes toward adolescent substance use and efforts to increase identification and intervention by middle school staff to reach youth from high-risk families.

  4. Consequences of long-distance swimming and travel over deep-water pack ice for a female polar bear during a year of extreme sea ice retreat

    Science.gov (United States)

    Durner, G.M.; Whiteman, J.P.; Harlow, H.J.; Amstrup, Steven C.; Regehr, E.V.; Ben-David, M.

    2011-01-01

    Polar bears (Ursus maritimus) prefer to live on Arctic sea ice but may swim between ice floes or between sea ice and land. Although anecdotal observations suggest that polar bears are capable of swimming long distances, no data have been available to describe in detail long distance swimming events or the physiological and reproductive consequences of such behavior. Between an initial capture in late August and a recapture in late October 2008, a radio-collared adult female polar bear in the Beaufort Sea made a continuous swim of 687 km over 9 days and then intermittently swam and walked on the sea ice surface an additional 1,800 km. Measures of movement rate, hourly activity, and subcutaneous and external temperature revealed distinct profiles of swimming and walking. Between captures, this polar bear lost 22% of her body mass and her yearling cub. The extraordinary long distance swimming ability of polar bears, which we confirm here, may help them cope with reduced Arctic sea ice. Our observation, however, indicates that long distance swimming in Arctic waters, and travel over deep water pack ice, may result in high energetic costs and compromise reproductive fitness. ?? 2011 US Government.

  5. Lung Metastasis of Primary Alveolar Soft-Part Sarcoma Occurring 20 Years after Initial Treatment

    Directory of Open Access Journals (Sweden)

    R. F. Falkenstern-Ge

    2013-01-01

    Full Text Available A 30-year old woman was referred to our center because of suspicion of a primary lung tumor of the right upper lobe. Histological examination of the lung lesion revealed lung metastasis of a previously treated alveolar soft part sarcoma of the musculus vastus medialis of the right femur, which was resected 20 years ago. Alveolar soft-part sarcoma is a rare malignant tumor that occurs most often in the soft tissue of lower limbs. It is a slow-growing malignant soft tissue tumor arising in muscle tissue, usually in young adults. Due to pleural and extensive mediastinal infiltration with bilateral lung metastases, a systemic treatment with chemotherapy doxorubicin and ifosfamide was initiated. Late metastases from previously treated alveolar part sarcoma should be considered in patients with suspicious lung lesions even if surgical treatment was performed a long time ago.

  6. Factors predicting Behavior Management Problems during Initial Dental Examination in Children Aged 2 to 8 Years.

    Science.gov (United States)

    Sharma, Arun; Kumar, Dipanshu; Anand, Ashish; Mittal, Vipula; Singh, Aparna; Aggarwal, Nidhi

    2017-01-01

    The aim of the present study was to identify the various background variables and its influence on behavior management problems (BMP) in children. The study included 165 children aged 2 to 8 years. During the initial dental visit, an experienced operator obtained each child's background variables from accompanying guardians using a standardized questionnaire. Children's dental behavior was rated by Frankel behavior rating scale. The behavior was then analyzed in relation to the answers of the questionnaire, and a logistic regression model was used to determine the power of the variables, separately or combined, to predict BMP. The logistic regression analysis considering differences in background variables between children with negative or positive behavior. Four variables turned out to be as predictors: Age, the guardian's expectation of the child's behavior at the dental examination, the child's anxiety when meeting unfamiliar people, and the presence and absence of toothache. The present study concluded that by means of simple questionnaire BMP in children may be expected if one of these attributes is found. Information on the origin of dental fear and uncooperative behavior in a child patient prior to treatment process may help the pediatric dentist plan appropriate behavior management and treatment strategy. Sharma A, Kumar D, Anand A, Mittal V, Singh A, Aggarwal N. Factors predicting Behavior Management Problems during Initial Dental Examination in Children Aged 2 to 8 Years. Int J Clin Pediatr Dent 2017;10(1):5-9.

  7. Initiation to scientific literacy in early years of elementary school: contributions of a didactic sequence

    Directory of Open Access Journals (Sweden)

    Juliana Pinto Viecheneski

    2013-12-01

    Full Text Available This article presents the results of a research professional, which was developed in the context of the early years of elementary school, from the application of a didactic sequence, with a view to initiation of scientific literacy of students in the literacy process of language. The methodological approach was qualitative, interpretative nature. The subjects were the students of 1st year 1st Cycle of Basic Education in a public school in Ponta Grossa - PR. The data were collected through observation, application of diagnostic testing, audio recordings, photographs, written records, illustrations and posttest. The theory History Cultural Development made the analysis of pedagogical actions and reflections on them. The main results indicate that the activities of the instructional sequence, contributed to the progressive advancement of the students' knowledge in relation to the area of science and basic scientific literacy, and also contributed to make learning the language more contextualized and interdisciplinary. It is noted that this work requires a teacher to assume the role of mediator between the scientific and the children, as well as requires the understanding that, as the subject entered the technological means, students in the early years have a right to access scientific culture. In this perspective, respecting the level of development of the children, the teacher can provide challenges and mediations necessary for the gradual construction of scientific knowledge, the first years of elementary school.

  8. Polarization Optics

    OpenAIRE

    Fressengeas, Nicolas

    2010-01-01

    The physics of polarization optics *Polarized light propagation *Partially polarized light; DEA; After a brief introduction to polarization optics, this lecture reviews the basic formalisms for dealing with it: Jones Calculus for totally polarized light and Stokes parameters associated to Mueller Calculus for partially polarized light.

  9. Recurrent advanced colonic cancer occurring 11 years after initial endoscopic piecemeal resection: a case report

    Directory of Open Access Journals (Sweden)

    Kishino Takayoshi

    2010-08-01

    Full Text Available Abstract Background The high frequency of local recurrence occurring after endoscopic piecemeal resection (EPMR for large colorectal tumors is a serious problem. However, almost all of these cases of local recurrence can be detected within 1 year and cured by additional endoscopic resection. We report a rare case of recurrent advanced colonic cancer diagnosed 11 years after initial EPMR treatment. Case presentation A 65-year-old male was diagnosed with a sigmoid colon lesion following a routine health check-up. Total colonoscopy revealed a 12 mm type 0-Is lesion in the sigmoid colon, which was diagnosed as an adenoma or intramucosal cancer and treated by EPMR in 1996. The post-resection defect was closed completely using metallic endoclips to avoid delayed bleeding. In 2007, at the third follow up, colonoscopy revealed a 20 mm submucosal tumor (SMT like recurrence at the site of the previous EPMR. The recurrent lesion was treated by laparoscopic assisted sigmoidectomy with lymph node dissection. Conclusion When it is difficult to evaluate the depth and margins of resected tumors following EPMR, it is important that the defect is not closed in order to avoid tumor implantation, missing residual lesions and to enable earlier detection of recurrence. It is crucial that the optimal follow-up protocol for EPMR cases is clarified, particularly how often and for how long they should be followed.

  10. Special initiatives FY 1995 Multi-Year Program Plan (MYPP)/Fiscal Year Work Plan (FYWP) WBS 5.0

    International Nuclear Information System (INIS)

    Jekel, R.A.

    1994-09-01

    The Special Initiatives mission supports programmatic requests for service to DOE offices, other organizations and agencies. These requests can include the following: Supporting priority DOE initiatives; Researching special programs; Studying locating new activities at the Hanford Site; Producing specialty materials; Providing consulting support to other sites; Managing a broad spectrum of US and international test programs

  11. Massive retroperitoneal ganglioneuroma presenting with small bowel obstruction 18 years following initial diagnosis.

    LENUS (Irish Health Repository)

    Cronin, E M P

    2012-02-03

    BACKGROUND: Ganglioneuroma is a rare tumour of neural crest origin, which arises from maturation of a neuroblastoma. While previously considered to be non-functioning, they are now known to be frequently endocrinologically active. AIMS AND METHODS: We report a case of a massive retroperitoneal ganglioneuroma presenting with small bowel obstruction in an adult, 18 years after initial diagnosis. Urinary dopamine levels were elevated, but other catecholamines were within normal limits. This is the first report in the English-language literature of a retroperitoneal ganglioneuroma presenting with or causing intestinal obstruction. We also review the metabolic, radiological, and histological features of these tumours. Relevant publications were identified from a Medline search using the MeSH headings \\'ganglioneuroma\\

  12. Brief summary of staffing levels at Fermilab during initial construction years

    International Nuclear Information System (INIS)

    Livdahl, P.V.

    1983-11-01

    This paper very briefly summarizes the work of the various groups that were involved from the beginning through the end of the initial construction phase of the Fermilab project (defined here to be July 1, 1972) and the final construction or completion phase which is here defined as December 31, 1973. The numbers in this report have been gathered by examining the personnel records of Fermilab with the research being done by Chuck Marofske, the Head of Laboratory Services and his staff and by assembling information from the memories of people still with the laboratory in 1983. Since there was much mobility within the laboratory during the construction years and frequent reorganizations were the norm, the numbers presented herein can not be considered to be more accurate than about +- 5%

  13. Deep Vadose Zone-Applied Field Research Initiative Fiscal Year 2011 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    Wellman, Dawn M.; Johnson, Timothy C.; Smith, Ronald M.; Truex, Michael J.; Matthews, Hope E.

    2011-10-01

    This annual report describes the background of the Deep Vadose Zone-Applied Field Research Initiative, and some of the programmatic approaches and transformational technologies in groundwater and deep vadose zone remediation developed during fiscal year 2011. The Department of Energy (DOE) Office of Technology Innovation and Development's (OTID) mission is to transform science into viable solutions for environmental cleanup. In 2010, OTID developed the Impact Plan, Science and Technology to Reduce the Life Cycle Cost of Closure to outline the benefits of research and development of the lifecycle cost of cleanup across the DOE complex. This plan outlines OTID's ability to reduce by $50 billion, the $200 billion life-cycle cost in waste processing, groundwater and soil, nuclear materials, and deactivation and decommissioning. The projected life-cycle costs and return on investment are based on actual savings realized from technology innovation, development, and insertion into remedial strategies and schedules at the Fernald, Mound, and Ashtabula sites. To achieve our goals, OTID developed Applied Field Research Initiatives to facilitate and accelerate collaborative development and implementation of new tools and approaches that reduce risk, cost and time for site closure. The primary mission of the Deep Vadose Zone-Applied Field Research Initiative (DVZ-AFRI) is to protect our nation's water resources, keeping them clean and safe for future generations. The DVZ-AFRI was established for the DOE to develop effective, science-based solutions for remediating, characterizing, monitoring, and predicting the behavior and fate of deep vadose zone contamination. Subsurface contaminants include radionuclides, metals, organics, and liquid waste that originated from various sources, including legacy waste from the nation's nuclear weapons complexes. The DVZ-AFRI project team is translating strategy into action by working to solve these complex challenges in a

  14. Deep Vadose Zone-Applied Field Research Initiative Fiscal Year 2011 Annual Report

    International Nuclear Information System (INIS)

    Wellman, Dawn M.; Johnson, Timothy C.; Smith, Ronald M.; Truex, Michael J.; Matthews, Hope E.

    2011-01-01

    This annual report describes the background of the Deep Vadose Zone-Applied Field Research Initiative, and some of the programmatic approaches and transformational technologies in groundwater and deep vadose zone remediation developed during fiscal year 2011. The Department of Energy (DOE) Office of Technology Innovation and Development's (OTID) mission is to transform science into viable solutions for environmental cleanup. In 2010, OTID developed the Impact Plan, Science and Technology to Reduce the Life Cycle Cost of Closure to outline the benefits of research and development of the lifecycle cost of cleanup across the DOE complex. This plan outlines OTID's ability to reduce by $50 billion, the $200 billion life-cycle cost in waste processing, groundwater and soil, nuclear materials, and deactivation and decommissioning. The projected life-cycle costs and return on investment are based on actual savings realized from technology innovation, development, and insertion into remedial strategies and schedules at the Fernald, Mound, and Ashtabula sites. To achieve our goals, OTID developed Applied Field Research Initiatives to facilitate and accelerate collaborative development and implementation of new tools and approaches that reduce risk, cost and time for site closure. The primary mission of the Deep Vadose Zone-Applied Field Research Initiative (DVZ-AFRI) is to protect our nation's water resources, keeping them clean and safe for future generations. The DVZ-AFRI was established for the DOE to develop effective, science-based solutions for remediating, characterizing, monitoring, and predicting the behavior and fate of deep vadose zone contamination. Subsurface contaminants include radionuclides, metals, organics, and liquid waste that originated from various sources, including legacy waste from the nation's nuclear weapons complexes. The DVZ-AFRI project team is translating strategy into action by working to solve these complex challenges in a collaborative

  15. Particulate export and lateral advection in the Antarctic Polar Front (Southern Pacific Ocean): One-year mooring deployment

    Science.gov (United States)

    Tesi, T.; Langone, L.; Ravaioli., M.; Giglio, F.; Capotondi, L.

    2012-12-01

    An instrumented mooring line with sediment traps, current meters and recorders of temperature and conductivity was deployed just south of the Antarctic Polar Front (63° 26‧ S, 178° 03‧E; water depth 4400 m) from January 9th 1999 to January 10th 2000. Sediment traps at 900 and 3700 m had a single large cup to collect particulate material throughout the 1-year study whereas time-series sediment traps were used to characterize the temporal variability at 1300 and 2400 m. Samples were characterized via several parameters including total mass flux, elemental composition (organic carbon, total nitrogen, biogenic silica, and calcium carbonate), concentration of metals (aluminum, iron, barium, and manganese), 210Pb activity, and foraminifera identification. High vertical fluxes of biogenic particles were observed in both summer 1999 and 2000 as a result of seasonal algal blooms associated with sea ice retreat and water column stratification. During autumn and winter, several high energy events occurred and resulted in advecting resuspended biogenic particles from flat-topped summits of the Pacific Antarctic Ridge. Whereas the distance between seabed and uppermost sediment traps was sufficient to avoid lateral advection processes, resuspension was significant in the lowermost sediment traps accounting for ~ 60 and ~ 90% of the material caught at 2400 and 3700 m, respectively. Although resuspended material showed an elemental composition relatively similar to vertical summer fluxes, samples collected during high energy events contained benthic foraminifera and exhibited significantly higher 210Pb activity indicating a longer residence time in the water column. In addition, during quiescent periods characterized by low mass fluxes, the content of lithogenic particles increased at the expense of phytodetritus indicating the influence of material advected through the benthic nepheloid layer. Organic matter content was particularly high during these periods and showed

  16. Five-year follow-up of Community Pediatrics Training Initiative.

    Science.gov (United States)

    Minkovitz, Cynthia S; Goldshore, Matt; Solomon, Barry S; Guyer, Bernard; Grason, Holly

    2014-07-01

    To compare community involvement of pediatricians exposed to enhanced residency training as part of the Dyson Community Pediatrics Training Initiative (CPTI) with involvement reported by a national sample of pediatricians. A cross-sectional analyses compared 2008-2010 mailed surveys of CPTI graduates 5 years after residency graduation with comparably aged respondents in a 2010 mailed national American Academy of Pediatrics survey of US pediatricians (CPTI: n = 234, response = 56.0%; national sample: n = 243; response = 59.9%). Respondents reported demographic characteristics, practice characteristics (setting, time spent in general pediatrics), involvement in community child health activities in past 12 months, use of ≥1 strategies to influence community child health (eg, educate legislators), and being moderately/very versus not at all/minimally skilled in 6 such activities (eg, identify community needs). χ(2) statistics assessed differences between groups; logistic regression modeled the independent association of CPTI with community involvement adjusting for personal and practice characteristics and perspectives regarding involvement. Compared with the national sample, more CPTI graduates reported involvement in community pediatrics (43.6% vs 31.1%, P .05). Differences in involvement remained in adjusted analyses with greater involvement by CPTI graduates (adjusted odds ratio 2.4, 95% confidence interval 1.5-3.7). Five years after residency, compared with their peers, more CPTI graduates report having skills and greater community pediatrics involvement. Enhanced residency training in community pediatrics may lead to a more engaged pediatrician workforce. Copyright © 2014 by the American Academy of Pediatrics.

  17. Supporting countries in establishing and strengthening NITAGs: lessons learned from 5 years of the SIVAC initiative.

    Science.gov (United States)

    Adjagba, Alex; Senouci, Kamel; Biellik, Robin; Batmunkh, Nyambat; Faye, Pape Coumba; Durupt, Antoine; Gessner, Bradford D; da Silva, Alfred

    2015-01-29

    To empower governments to formulate rational policies without pressure from any group, and to increase the use of evidence-based decision-making to adapt global recommendations on immunization to their local context, the WHO has recommended on multiple occasions that countries should establish National Immunization Technical Advisory Groups (NITAGs). The World Health Assembly (WHA) reinforced those recommendations in 2012 when Member States endorsed the Decade of Vaccines Global Vaccine Action Plan (GVAP). NITAGs are multidisciplinary groups of national experts responsible for providing independent, evidence-informed advice to health authorities on all policy-related issues for all vaccines across all populations. In 2012, according to the WHO-UNICEF Joint Reporting Form, among 57 countries eligible for immunization program financial support from the GAVI Alliance, only 9 reported having a functional NITAG. Since 2008, the Supporting Independent Immunization and Vaccine Advisory Committees (SIVAC) Initiative (at the Agence de Médecine Préventive or AMP) in close collaboration with the WHO and other partners has been working to accelerate and systematize the establishment of NITAGs in low- and middle-income countries. In addition to providing direct support to countries to establish advisory groups, the initiative also supports existing NITAGs to strengthen their capacity in the use of evidence-based processes for decision-making aligned with international standards. After 5 years of implementation and based on lessons learned, we recommend that future efforts should target both expanding new NITAGs and strengthening existing NITAGs in individual countries, along three strategic lines: (i) reinforce NITAG institutional integration to promote sustainability and credibility, (ii) build technical capacity within NITAG secretariats and evaluate NITAG performance, and (iii) increase networking and regional collaborations. These should be done through the development

  18. Fukushima, one year later. Initial analyses of the accident and its consequences

    International Nuclear Information System (INIS)

    2012-01-01

    The earthquake of magnitude 9 of March 11, 2011 with an epicenter 80 km east of the Japanese island of Honshu, and the subsequent tsunami, severely affected the region of Tohoku, with major consequences for its population and infrastructure. Devastating the site of the Fukushima Dai-ichi nuclear power plant, these natural events were the cause of the core meltdowns of three nuclear reactors and the loss of cooling of several spent fuel pools. Explosions also occurred in reactor buildings 1 through 4 due to hydrogen produced during fuel degradation. Very significant radioactive releases into the environment took place. The accident was classified level 7 on the International Nuclear Event Scale (INES). This report provides an assessment and perspective on the information gathered by IRSN during the first twelve months following the disaster in an effort to understand the condition of the installations, evaluate the releases and analyze and evaluate the consequences of the accident on workers and the impact on the population and the environment. On the basis of available information, the report provides an initial analysis of the chain of events. It should be noted that a year after the accident, the full sequence of events is still not understood. Operating experience feedback from the 1979 Three Mile Island accident in the United States, in which reactor core damage was not confirmed until 1986, suggests that it may be several years before a detailed scenario can be constructed of the accident that led to radioactive releases. It will require access to the damaged installations. The situation at the site remains dangerous (reactor pressure vessels and containments are not leak-tight, diffuse releases, etc.). If it has significantly improved as a result of the significant resources deployed by the Tokyo Electro Power Company (TEPCO) to regain control of the installations, this effort must continue over the long term to begin evacuation of fuel from pools (in two

  19. Five Years On: Tsunami Risk Mitigation and Disaster Management Initiatives in Sri Lanka

    Science.gov (United States)

    Jayasekera Wijetunge, J.

    2009-12-01

    The Indian Ocean tsunami in 2004 caused unprecedented loss of lives and damage to property in Sri Lanka with over 35,000 killed, 20,000 injured and about 100,000 dwellings and other buildings destroyed or damaged. This catastrophic event also exposed lack of disaster preparedness at the time in Sri Lanka and underscored the need for pro-active disaster planning and risk mitigation. Given the apparently low probability of recurrence of destructive ocean-wide tsunami similar to that in 2004, Sri Lanka preferred an integrated approach to tsunami risk mitigation consisting primarily of non-structural measures, namely, public education and awareness; early warning and evacuation; hazard and risk mapping; and necessary institutional and legislative initiatives. The Indian Ocean Tsunami Warning System currently under development, though by no means foolproof, will help improve Sri Lanka’s tsunami early warning capability and reliability. Yet, the more difficult and challenging task will be the dissemination of such tsunami warnings fast and effectively to the vulnerable communities so as to enable their evacuation to safe locations. The Disaster Management Centre of the Government of Sri Lanka has been coordinating all activities related to disaster risk mitigation in the country. Their efforts have indeed been commendable, particularly in setting up of institutional mechanisms to better coordinate risk mitigation activities and in strengthening, streamlining and directing the capabilities and resources of relevant governmental and non-governmental organizations towards a common goal of disaster risk reduction through a multi-hazard approach. The university system in Sri Lanka also has made many contributions towards disaster mitigation through capacity building initiatives, hazard mapping and research. On the whole, Sri Lanka has taken significant steps towards disaster risk reduction since the tsunami devastation in 2004. The country now has a sound disaster risk

  20. Initial 2-year results of CardioCel® patch implantation in children.

    Science.gov (United States)

    Pavy, Carine; Michielon, Guido; Robertus, Jan Lukas; Lacour-Gayet, François; Ghez, Olivier

    2018-03-01

    We present the initial 2-year results of CardioCel® patch (Admedus Regen Pty Ltd, Perth, WA, Australia) implantation in paediatric patients with congenital heart diseases. This was a single-centre retrospective study with prospectively collected data of all patients aged 18 years and under operated for congenital heart disease. The patch was introduced in 2014, with clinical practice committee approval and a special consent in case of an Ozaki procedure. Standard follow-up was performed with systematic clinical exams and echocardiograms. In case of reoperation or graft failure, the patch was removed and sent for a histological examination. Between March 2014 and April 2016, 101 patients had surgical repair using a CardioCel patch. The mean age was 22 (±36.3) months, and the mean weight was 9.7 (±10.3) kg. No infections and no intraoperative implantation difficulties were associated with the patch. The median follow-up period was 212 (range 4-726) days. The overall 30-day postoperative mortality was 3.8% (n = 4), none of which were related to graft failure. Five children were reoperated because of graft failure, 4 of whom had the patch implanted for aortic and were aged less than 10 days. The indications for patch implantation in the aortic position were aortopulmonary window, truncus arteriosus, coarctation and aortic arch hypoplasia repair. The median time between the first and the second operation for graft failure was 245 (range 5-480) days. Our experience shows that the patch is well tolerated in the septal, valvar and pulmonary artery positions. However, we experienced graft failures in infants in the aortic position. © The Author 2017. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.

  1. Initial Management of Childhood Acute Immune Thrombocytopenia: Single-Center Experience of 32 Years.

    Science.gov (United States)

    Yildiz, Inci; Ozdemir, Nihal; Celkan, Tiraje; Soylu, Selen; Karaman, Serap; Canbolat, Aylin; Dogru, Omer; Erginoz, Ethem; Apak, Hilmi

    2015-01-01

    Immune thrombocytopenia (ITP) is an acute self-limited disease of childhood, mostly resolving within 6 months irrespective of whether therapy is given or not. Treatment options when indicated include corticosteroids, intravenous immune globulin (IVIG), and anti-RhD immunoglobulin. We reviewed our 32 years' experience for first-line therapy of acute ITP. Five hundred forty-one children (mean age: 5.3 years) diagnosed and treated for ITP were evaluated retrospectively. Among 491 acute ITP patients, IVIG was used in 27%, high-dose steroids in 27%, low-dose steroids in 20%, anti-D immunoglobulin G (IgG) in 2%, and no therapy in 22%. When the initial response (platelets >50 × 10(9)/L) to first-line treatment modalities were compared, 89%, 84%, and 78% patients treated by low-dose steroids, high-dose steroids, and IVIG responded to treatment, respectively (P > .05). Mean time to recovery of platelets was 16.8, 3.8, and 3.0 days in patients treated with low-dose steroids, high-dose steroids, and IVIG, respectively (P < .0001). Thrombocytopenia recurred in 23% of low-dose steroid, 39% of high-dose steroid, and in 36% of IVIG (P < .0001) treatment groups. Of 108 patients who were observed alone, 4 (3%) had a recurrence on follow-up and only 2 of these required treatment subsequently. Recurrence was significantly less in no therapy group compared with children treated with 1 of the 3 options of pharmacotherapy (P < .0001). Response rates were similar between patients treated by IVIG and low- and high-dose steroids; however, time to response was slower in patients treated with low-dose steroids compared with IVIG and high-dose steroids.

  2. The long view of nanotechnology development: the National Nanotechnology Initiative at 10 years

    International Nuclear Information System (INIS)

    Roco, Mihail C.

    2011-01-01

    A global scientific and societal endeavor was set in motion by the nanotechnology vision formulated in 1999 that inspired the National Nanotechnology Initiative (NNI) and other national and international R and D programs. Establishing foundational knowledge at the nanoscale has been the main focus of the nanotechnology research community in the first decade. As of 2009, this new knowledge underpinned about a quarter of a trillion dollars worldwide market, of which about $91 billion was in US products that incorporate nanoscale components. Nanotechnology is already evolving toward becoming a general-purpose technology by 2020, encompassing four generations of products with increasing structural and dynamic complexity: (1) passive nanostructures, (2) active nanostructures, (3) nanosystems, and (4) molecular nanosystems. By 2020, the increasing integration of nanoscale science and engineering knowledge and of nanosystems promises mass applications of nanotechnology in industry, medicine, and computing, and in better comprehension and conservation of nature. Nanotechnology’s rapid development worldwide is a testimony to the transformative power of identifying a concept or trend and laying out a vision at the synergistic confluence of diverse scientific research areas. This chapter provides a brief perspective on the development of the NNI since 2000 in the international context, the main outcomes of the R and D programs after 10 years, the governance aspects specific to this emerging field, lessons learned, and most importantly, how the nanotechnology community should prepare for the future.

  3. Hawaii Clean Energy Initiative 2008-2018: Celebrating 10 Years of Success

    Energy Technology Data Exchange (ETDEWEB)

    2018-01-04

    Launched in January 2008, the Hawaii Clean Energy Initiative (HCEI) set out transform Hawaii into a world model for energy independence and sustainability. With its leading-edge vision to transition to a Hawaii-powered clean energy economy within a single generation, HCEI established the most aggressive clean energy goals in the nation. Ten years after its launch, HCEI has significantly outdistanced the lofty targets established as Hawaii embarked on its ambitious quest for energy independence. The state now generates 27 percent of its electricity sales from clean energy sources like wind and solar, placing it 12 percentage points ahead of HCEI's original 2015 RPS target of 15 percent. This brochure highlights some of HCEI's key accomplishments and impacts during its first decade and reveals how its new RPS goal of 100 percent by 2045, which the Hawaii state legislature adopted in May 2015, has positioned Hawaii to become the first U.S. state to produce all of its electricity from indigenous renewable sources.

  4. Special initiatives FY 1996 multi-year program plan (MYPP) WBS 5.0. Revision 1

    International Nuclear Information System (INIS)

    Howald, S.C.

    1995-09-01

    The Special Initiatives mission supports programmatic requests for service to DOE offices, other organizations and agencies. These requests can include the following: Supporting priority DOE initiatives, researching special programs, studying locating new activities ar the Hanford Site, producing specialty materials, providing consulting support to other sites, and managing a broad spectrum of US and international test programs. The Special Initiatives Program discussed in this plan consists of the following elements: space power programs, advanced programs, special programs, and program strategy

  5. The Early College High School Initiative: An Overview of Five Evaluation Years

    Science.gov (United States)

    Berger, Andrea; Adelman, Nancy; Cole, Susan

    2010-01-01

    In 2002, the Bill & Melinda Gates Foundation started the Early College High School Initiative (ECHSI). Through this initiative, more than 200 Early College Schools (ECSs) opened by fall 2009. All of the schools aim to provide underserved students access to college classes while in high school. This article will provide an overview of the first 6…

  6. Expansion and Polarity Sorting in Microtubule-Dynein Bundles(WHAT IS LIFE? THE NEXT 100 YEARS OF YUKAWA'S DREAM)

    OpenAIRE

    Assaf, ZEMEL; Alex, MOGILNER; Department of Neurobiology, Physiology and Behavior, University of California; Department of Neurobiology, Physiology and Behavior, University of California

    2008-01-01

    Interactions of multiple molecular motors with dynamic polymers, such as actin and microtubules, form the basis for many processes in the cell cytoskeleton. One example is the active 'sorting' of microtubule bundles by dynein molecular motors into aster-like arrays of microtubules; in these bundles dynein motors cross-link and slide neighboring microtubules apart. A number of models have been suggested to quantify the active dynamics of cross-linked bundles of polar filaments. In the case of ...

  7. Polarized Electrons at Jefferson Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Sinclair, C.K.

    1997-12-31

    The CEBAF accelerator at Jefferson laboratory can deliver CW electron beams to three experimental halls simultaneously. A large fraction of the approved scientific program at the lab requires polarized electron beams. Many of these experiments, both polarized and unpolarized, require high average beam current as well. Since all electrons delivered to the experimental halls originate from the same cathode, delivery of polarized beam to a single hall requires using the polarized source to deliver beam to all experiments in simultaneous operation. The polarized source effort at Jefferson Lab is directed at obtaining very long polarized source operational lifetimes at high average current and beam polarization; at developing the capability to deliver all electrons leaving the polarized source to the experimental halls; and at delivering polarized beam to multiple experimental halls simultaneously.initial operational experience with the polarized source will be presented.

  8. Polarized electrons at Jefferson laboratory

    International Nuclear Information System (INIS)

    The CEBAF accelerator at Jefferson laboratory can deliver CW electron beams to three experimental halls simultaneously. A large fraction of the approved scientific program at the lab requires polarized electron beams. Many of these experiments, both polarized and unpolarized, require high average beam current as well. Since all electrons delivered to the experimental halls originate from the same cathode, delivery of polarized beam to a single hall requires using the polarized source to deliver beam to all experiments in simultaneous operation. The polarized source effort at Jefferson Lab is directed at obtaining very long polarized source operational lifetimes at high average current and beam polarization; at developing the capability to deliver all electrons leaving the polarized source to the experimental halls; and at delivering polarized beam to multiple experimental halls simultaneously. Initial operational experience with the polarized source will be presented

  9. Quality evaluation of initial formation in the third year of medical course.

    Directory of Open Access Journals (Sweden)

    Berto Delis Conde Fernández

    2011-09-01

    Full Text Available The priority given by Cuba to the accreditation of initial formation in medical course encourages the introduction of procedures for self assessment. With the objective to contribute to quality management in initial formation of this course by means of the implementation of a self assessment institutional system applicable to the University Hospital, a quasi experiemental investigation was made in “Camilo Cienfuegos” Provincial Hospital, Sancti Spiritus during the period 2005-2010. Different instruments were applied for obtaining the initial information and were determined quality indicators, methods and evaluation procedures, from which it was designed and validated a methodology for the self assessment process, including its quality standard. The results of measurements and the analysis of quality tendency were presented. It concludes highlighting the contribution achieved due to the development of a quality culture and evaluation, orientation towards the continuous perfectioning and organizational change.

  10. A dynamically polarized hydrogen and deuterium target at Jefferson Lab

    International Nuclear Information System (INIS)

    Polarized electron beams have been successfully used at Jefferson Lab for over a year. The authors now report the successful achievement of polarized targets for nuclear and particle physics experiments using the dynamic nuclear polarization (DNP)technique. The technique involves initial irradiation of frozen ammonia crystals (NH 3 and ND 3 ) using the electron beam from the new Free Electron Laser (FEL) facility at Jefferson Lab, and transferring the crystals to a special target holder for use in Experimental Halls. By subjecting the still ionized and frozen ammonia crystals to a strong magnetic field and suitably tuned RF, the high electron polarization is transmitted to the nucleus thus achieving target polarization. Details of the irradiation facility, the target holder, irradiation times, ionized crystal shelf life, and achieved polarization are discussed

  11. One-Year Mortality Rates Before and After Implementing Quality-Improvement Initiatives to Prevent Inpatient Falls (2012–2016

    Directory of Open Access Journals (Sweden)

    Inderpal Singh

    2018-03-01

    Full Text Available Single-room ward design has previously been associated with increased risk of inpatient falls and adverse outcomes. However, following quality initiatives, the incidence of inpatient falls has shown a sustained reduction. Benefits have also been observed in the reduction of hip fractures. However, one-year mortality trends have not been reported. The aim of this observational study is to report the trends in one-year mortality rates before and after implementing quality-improvement initiatives to prevent inpatient falls over the last 5 years (2012–2016. This retrospective observational study was conducted for all patients who had sustained an inpatient fall between January 2012 and December 2016. All the incident reports in DATIX patient-safety software which were completed for each inpatient fall were studied, and the clinical information was extracted from Clinical Work Station software. Mortality data were collected on all patients for a minimum of one year following the discharge from the hospital. The results show that 95% patients were admitted from their own homes; 1704 patients had experienced 3408 incidents of an inpatient fall over 5 years. The mean age of females (82.61 ± 10.34 years was significantly higher than males (79.36 ± 10.14 years. Mean falls/patient = 2.0 ± 2.16, range 1–33. Mean hospital stay was 45.43 ± 41.42 days. Mean hospital stay to the first fall was 14.5 ± 20.79 days, and mean days to first fall prior to discharge was 30.8 ± 34.33 days. The results showed a significant and sustained reduction in the incidence of inpatient falls. There was a downward trend in the incidence of hip fractures over the last two years. There was no significant difference in the inpatient and 30-day mortality rate over the last five years. However, mortality trends appear to show a significant downward trend in both six-month and one-year mortality rates over the last two years following the implementation of quality initiatives

  12. 76 FR 58827 - Announcement of Funding Awards; Fair Housing Initiatives Program Fiscal Year (FY) 2009

    Science.gov (United States)

    2011-09-22

    ... First (FIRST) training. FIRST is a major training initiative to assist architects, builders, disability... Monticello Avenue, Ste. 104 (434) 817-2436 3 64,139.00 Charlottesville, VA 22902 Legal Aid Society of Palm... Legal Aid Services of Oregon: 921 SW. Washington Street, Ste. (503) 224-4094 10 100,000.00 570, Portland...

  13. Spreading the Gospel of Information Literacy: A Schoolwide Initiative, Year Two.

    Science.gov (United States)

    Valenza, Joyce Kasman

    2003-01-01

    Describes a schoolwide research improvement initiative that was designed to improve information literacy in a high school setting. Discusses self-study and examination of student work; cognitive issues; school culture; online resources that were developed; improving search strategies; discouraging electronic plagiarism; creating pathfinders;…

  14. Motivational Interviewing Training for Juvenile Correctional Staff in California: One Year Initial Outcomes

    Science.gov (United States)

    Hohman, Melinda; Doran, Neal; Koutsenok, Igor

    2009-01-01

    This study reports initial results of a program designed to train California corrections staff (n = 576) in motivational interviewing (MI), a method of communication that is based on a client-centered, collaborative style. After three days of training, participants made significant gains in terms of knowledge of MI principles and reflective…

  15. 78 FR 33063 - Initiation of Five-Year (“Sunset”) Review

    Science.gov (United States)

    2013-06-03

    ...; Final Modification, 77 FR 8101 (February 14, 2012). Initiation of Review In accordance with 19 CFR 351... submitted in response to questionnaires; (ii) evidence submitted in support of allegations; (iii) publicly available information to value factors under 19 CFR 351.408(c) or to measure the adequacy of remuneration...

  16. 78 FR 46575 - Initiation of Five-Year (“Sunset”) Review

    Science.gov (United States)

    2013-08-01

    ... Duty Proceedings; Final Modification, 77 FR 8101 (February 14, 2012). Initiation of Review In....102(b)(21), which are summarized as follows: (i) evidence submitted in response to questionnaires; (ii) evidence submitted in support of allegations; (iii) publicly available information to value factors under...

  17. 75 FR 60731 - Initiation of Five-Year (“Sunset”) Review

    Science.gov (United States)

    2010-10-01

    ... Porcelain-on-Steel Jennifer Moats Cooking Ware (3rd (202) 482-5047. Review). A-570-855 731-TA-841 PRC Apple... participate. See 19 CFR 351.218(d)(1)(i). The required contents of the notice of intent to participate are set... Register of this notice of initiation. The required contents of a substantive response, on an order...

  18. 76 FR 58822 - Announcement of Funding Awards; Fair Housing Initiatives Program; Fiscal Year 2010

    Science.gov (United States)

    2011-09-22

    ..., 208-383-0695. 10 324,839.00 9th Street, Suite M 200, Boise, ID 83702. Private Enforcement Initiative...., Rancho Cucamor, CA 91730. Fair Housing of Marin: 615 B Street, San Rafael, CA Nancy Kenyon, 415-457-5025...

  19. Children's Futures' First Five Years: Lessons and Early Outcomes of a Community Change Initiative

    Science.gov (United States)

    Walker, Karen E.

    2008-01-01

    In 2002, The Robert Wood Johnson Foundation launched an early childhood initiative in Trenton, NJ, called "Children's Futures" (CF) to determine if focused efforts to bring about community change could make measurable differences in children's health and well-being and help ensure their readiness to enter school. The Foundation engaged…

  20. Cost per patient-year in response using a claims-based algorithm for the 2 years following biologic initiation in patients with rheumatoid arthritis.

    Science.gov (United States)

    Bonafede, Machaon; Johnson, Barbara H; Princic, Nicole; Shah, Neel; Harrison, David J

    2015-05-01

    To estimate cost per patient-year in response during 2 years following biologic initiation among patients with rheumatoid arthritis (RA). Adults newly initiating biologics for RA (etanercept, abatacept, adalimumab, certolizumab, golimumab, or infliximab) between January 2009 and July 2011 were identified in the MarketScan Commercial Database. Eligible patients were continuously enrolled 6 months before (pre-index) and 24 months after (post-index) their first (index) biologic claim. Biologic effectiveness was assessed using six criteria during 2-year follow-up: treatment adherence ≥80%, no biologic dose escalation, no biologic switch, no new disease-modifying anti-rheumatic drug, no new/increased glucocorticoid dose, and limited intra-articular joint injections (≤2). After a 90-day period of non-response for a treatment failure, effectiveness or failure of subsequent treatment was assessed again for the index biologic or new biologic (after switching). Post-index RA-related medical, pharmacy, and drug administration costs were attributed to the index biologic. Cost per patient-year in response was calculated as RA-related costs divided by duration of response. Overall, 15.0% of patients (1229/8193) did not fail any criterion for 2 years and were effectively treated. Mean duration of response was highest for etanercept (538.3 days), followed by golimumab (537.0 days; p = 0.864), adalimumab (534.7 days; p = 0.301), certolizumab (524.0 days; p = 0.165), infliximab (480.0 days; p < 0.001), and abatacept (482.3 days; p < 0.001). Total disease-related cost per patient-year in response was lower for patients initiated on etanercept ($25,086) than for patients initiated on adalimumab ($25,960), certolizumab ($26,339), golimumab ($26,332), abatacept ($35,581), or infliximab ($36,107). This study was limited to employer-paid commercial insurance. Database analyses cannot determine reasons for failing criteria. The algorithm was not designed and

  1. 78 FR 55091 - Fair Housing Initiatives Program-Fiscal Year 2013 Application and Award Policies and Procedures...

    Science.gov (United States)

    2013-09-09

    ... on the Applications and Awards Procedures and Policies (AAPP) Guide, which can be found at: http... URBAN DEVELOPMENT Fair Housing Initiatives Program--Fiscal Year 2013 Application and Award Policies and Procedures--Solicitation of Comment AGENCY: Office of the Assistant Secretary for Fair Housing and Equal...

  2. 75 FR 53272 - Endangered and Threatened Species; Initiation of 5-Year Review of the Eastern Distinct Population...

    Science.gov (United States)

    2010-08-31

    ... and Threatened Species; Initiation of 5-Year Review of the Eastern Distinct Population Segment of the... Distinct Population Segment (DPS) of the Steller Sea Lion (Eumetopias jubatus) under the Endangered Species... Distinct Population Segment (DPS) of the Steller Sea Lion (Eumetopias jubatus) under the Endangered Species...

  3. Treatment interruption after 2-year antiretroviral treatment initiated during acute/early HIV in infancy.

    Science.gov (United States)

    Wamalwa, Dalton; Benki-Nugent, Sarah; Langat, Agnes; Tapia, Kenneth; Ngugi, Evelyn; Moraa, Helen; Maleche-Obimbo, Elizabeth; Otieno, Vincent; Inwani, Irene; Richardson, Barbra A; Chohan, Bhavna; Overbaugh, Julie; John-Stewart, Grace C

    2016-09-24

    Treatment interruption has been well tolerated and durable in some pediatric studies but none have compared treatment interruption with continued antiretroviral treatment (ART) following ART initiation in early HIV. The objective of this study was to compare outcomes in treatment interruption versus continued ART among early-treated infants. Randomized trial (OPH-03; NCT00428116). The trial included HIV-infected infants who initiated ART at less than 13 months of age, received ART for 24 months, and, if eligible (CD4% >25%, normal growth), were randomized to treatment interruption versus continued ART. Children in the treatment interruption group restarted ART if they met WHO ART-eligibility criteria. During 18-months postrandomization, primary outcomes were incidence of serious adverse events and growth. CD4%, viral load, morbidity, and growth were compared. Of 140 infants enrolled, 121 started ART, of whom 75 completed at least 24 months ART and 42 were randomized (21 per arm). ART was initiated at median age 5 months and randomization at 30 months. Among 21 treatment interruption children, 14 met ART restart criteria within 3 months. Randomization was discontinued by Data and Safety Monitoring Board due to low treatment interruption durability. At 18 months postrandomization, growth and serious adverse events were comparable between arms; hypercholesteremia incidence was higher in the continued arm (P = 0.03). CD4% and viral load did not differ between arms [CD4% 35% and median viral load undetectable (<150 copies/ml) in both arms, P = 0.9 for each comparison]. No infants had post-treatment viral control. Short treatment interruption did not compromise 18-month CD4%, viral control, growth, or morbidity compared with continued ART among infants who started ART in early HIV infection.

  4. Strategic Polarization.

    Science.gov (United States)

    Kalai, Adam; Kalai, Ehud

    2001-08-01

    In joint decision making, similarly minded people may take opposite positions. Consider the example of a marriage in which one spouse gives generously to charity while the other donates nothing. Such "polarization" may misrepresent what is, in actuality, a small discrepancy in preferences. It may be that the donating spouse would like to see 10% of their combined income go to charity each year, while the apparently frugal spouse would like to see 8% donated. A simple game-theoretic analysis suggests that the spouses will end up donating 10% and 0%, respectively. By generalizing this argument to a larger class of games, we provide strategic justification for polarization in many situations such as debates, shared living accommodations, and disciplining children. In some of these examples, an arbitrarily small disagreement in preferences leads to an arbitrarily large loss in utility for all participants. Such small disagreements may also destabilize what, from game-theoretic point of view, is a very stable equilibrium. Copyright 2001 Academic Press.

  5. Trends in one-year cumulative incidence of death between 2005 and 2013 among patients initiating antiretroviral therapy in Uganda.

    Science.gov (United States)

    Bebell, Lisa M; Siedner, Mark J; Musinguzi, Nicholas; Boum, Yap; Bwana, Bosco M; Muyindike, Winnie; Hunt, Peter W; Martin, Jeffrey N; Bangsberg, David R

    2017-07-01

    Recent ecological data demonstrate improving outcomes for HIV-infected people in sub-Saharan Africa. Recently, Uganda has experienced a resurgence in HIV incidence and prevalence, but trends in HIV-related deaths have not been well described. Data were collected through the Uganda AIDS Rural Treatment Outcomes (UARTO) Study, an observational longitudinal cohort of Ugandan adults initiating antiretroviral therapy (ART) between 2005 and 2013. We calculated cumulative incidence of death within one year of ART initiation, and fit Poisson models with robust variance estimators to estimate the effect enrollment period on one-year risk of death and loss to follow-up. Of 760 persons in UARTO who started ART, 30 deaths occurred within one year of ART initiation (cumulative incidence 3.9%, 95% confidence interval [CI] 2.7-5.6%). Risk of death was highest for those starting ART in 2005 (13.0%, 95% CI 6.0-24.0%), decreased in 2006-2007 to 4% (95% CI 2.0-6.0%), and did not change thereafter ( P = 0.61). These results were robust to adjustment for age, sex, CD4 cell count, viral load, asset wealth, baseline depression, and body mass index. Here, we demonstrate that one-year cumulative incidence of death was high just after free ART rollout, decreased the following year, and remained low thereafter. Once established, ART programs in President's Emergency Fund for AIDS Relief-supported countries can maintain high quality care.

  6. Marine debris removal: one year of effort by the Georgia Sea Turtle-Center-Marine Debris Initiative.

    Science.gov (United States)

    Martin, Jeannie Miller

    2013-09-15

    Once in the marine environment, debris poses a significant threat to marine life that can be prevented through the help of citizen science. Marine debris is any manufactured item that enters the ocean regardless of source, commonly plastics, metal, wood, glass, foam, cloth, or rubber. Citizen science is an effective way to engage volunteers in conservation initiatives and provide education and skill development. The Georgia Sea Turtle Center Marine Debris Initiative (GSTC-MDI) is a grant funded program developed to engage citizens in the removal of marine debris from the beaches of Jekyll Island, GA, USA and the surrounding areas. During the first year of effort, more than 200 volunteers donated over 460 h of service to the removal of marine debris. Of the debris removed, approximately 89% were plastics, with a significant portion being cigarette materials. Given the successful first year, the GSTC-MDI was funded again for a second year. Copyright © 2013 Elsevier Ltd. All rights reserved.

  7. Single Jejunum Metastasis from Breast Cancer Arising Twelve Years after the Initial Treatment

    Directory of Open Access Journals (Sweden)

    Cláudia Paiva

    2016-01-01

    Full Text Available Metastatic involvement of gastrointestinal tract from breast cancer is a rare event. We report the case of a 61-year-old woman presenting with bowel obstruction, related to metastasis of a primary breast cancer she had 12 years earlier (a triple-negative invasive ductal carcinoma treated with surgery and chemotherapy. Bowel obstruction was caused by a 20-centimeter tumor in the jejunum, involving also the transverse colon. The patient underwent en bloc resection of tumor with jejunum and transverse bowel segment and received adjuvant chemotherapy with carboplatin and paclitaxel. Twenty months later, she was alive without disease recurrence.

  8. Ten Years of Northern Eurasia Earth Science Partnership Initiative (NEESPI): Results and Future Plans

    Science.gov (United States)

    Groisman, P. Y.; Gutman, G.; Gulev, S.; Maksyutov, S. S.

    2014-12-01

    During recent decades, Northern Eurasia was affected by unprecedented climate and environmental changes. Several droughts and heat waves alternated with hazardous extreme precipitation and flood events. Permafrost thaw, retreating Arctic sea ice, increasing areas of forest fire, and dramatic regional warming buffeted this region, tossing northern Eurasia from one extreme condition to the next. The region stores nearly half of the Earth's terrestrial carbon in permafrost, wetlands, and forested land, so ecosystem changes that release stored carbon could profoundly affect the world's climate. Furthermore, changes to climate and to hydrological and biogeochemical cycles are starting to affect daily life. For example, infrastructure is collapsing as permafrost thaws, severe winter storms increasingly bring businesses to a halt, and a growing water deficit is beginning to strain agricultural production and forestry. To pool resources and facilitate research, the Northern Eurasia Earth Science Partnership Initiative (NEESPI, http://neespi.org) was launched in 2004. With its multidisciplinary focus, the internationally funded NEESPI (more than165 individual international projects during the past decade) has challenged participants to research climate-ecosystem interactions, societal impacts from extreme events in Northern Eurasia, and the feedbacks of these interactions and impacts to the global Earth system. Among the numerous Institutional and private sponsors from the United States, European Union, Russia, China, and Japan, the cornerstone support for the NEESPI studies was provided by the NASA Land Cover and Land Use Change Program and the Russian Academy of Sciences. At this presentation we shall overview the environmental studies conducted by the NEESPI community, brief the audience about the main achievements of the NEESPI researchers, and lay down the plans for the future studies. At the side event of the Meeting, we are going to initiate preparation of the book

  9. High Performance Parallel Processing Project: Industrial computing initiative. Progress reports for fiscal year 1995

    Energy Technology Data Exchange (ETDEWEB)

    Koniges, A.

    1996-02-09

    This project is a package of 11 individual CRADA`s plus hardware. This innovative project established a three-year multi-party collaboration that is significantly accelerating the availability of commercial massively parallel processing computing software technology to U.S. government, academic, and industrial end-users. This report contains individual presentations from nine principal investigators along with overall program information.

  10. Unilateral proptosis as initial presenting sign of prostate cancer in a 45-year-old man

    Directory of Open Access Journals (Sweden)

    Elizabeth Bearrick

    2018-03-01

    Full Text Available We describe the case of 45-year-old man presented with a 3-month history of progressive unilateral proptosis, voiding symptoms, and a 20-pound weight loss. Imaging showed a large brain mass as well as significant extra cranial involvement. He was diagnosed with metastatic prostatic adenocarcinoma and underwent craniotomy, androgen deprivation therapy, and chemotherapy.

  11. Vowel Confusion Patterns in Adults during Initial 4 Years of Implant Use

    Science.gov (United States)

    Vaalimaa, Taina T.; Sorri, Martti J.; Laitakari, Jaakko; Sivonen, Ville; Muhli, Arto

    2011-01-01

    This study investigated adult cochlear implant users' (n == 39) vowel recognition and confusions by an open-set syllable test during 4 years of implant use, in a prospective repeated-measures design. Subjects' responses were coded for phoneme errors and estimated by the generalized mixed model. Improvement in overall vowel recognition was highest…

  12. Weekly gridded Aquarius L-band radiometer/scatterometer observations and salinity retrievals over the polar regions - Part 2: Initial product analysis

    Science.gov (United States)

    Brucker, L.; Dinnat, E. P.; Koenig, L. S.

    2014-05-01

    Following the development and availability of Aquarius weekly polar-gridded products, this study presents the spatial and temporal radiometer and scatterometer observations at L band (frequency ~1.4 GHz) over the cryosphere including the Greenland and Antarctic ice sheets, sea ice in both hemispheres, and over sub-Arctic land for monitoring the soil freeze/thaw state. We provide multiple examples of scientific applications for the L-band data over the cryosphere. For example, we show that over the Greenland Ice Sheet, the unusual 2012 melt event lead to an L-band brightness temperature (TB) sustained decrease of ~5 K at horizontal polarization. Over the Antarctic ice sheet, normalized radar cross section (NRCS) observations recorded during ascending and descending orbits are significantly different, highlighting the anisotropy of the ice cover. Over sub-Arctic land, both passive and active observations show distinct values depending on the soil physical state (freeze/thaw). Aquarius sea surface salinity (SSS) retrievals in the polar waters are also presented. SSS variations could serve as an indicator of fresh water input to the ocean from the cryosphere, however the presence of sea ice often contaminates the SSS retrievals, hindering the analysis. The weekly grided Aquarius L-band products used are distributed by the US Snow and Ice Data Center at blank"> http://nsidc.org/data/aquarius/index.html , and show potential for cryospheric studies.

  13. Boys with Asperger Syndrome Grow Up: Psychiatric and Neurodevelopmental Disorders 20 Years After Initial Diagnosis.

    Science.gov (United States)

    Gillberg, I Carina; Helles, Adam; Billstedt, Eva; Gillberg, Christopher

    2016-01-01

    We examined comorbid psychiatric and neurodevelopmental disorders in fifty adult males (mean age 30 years) with Asperger syndrome (AS) diagnosed in childhood and followed up prospectively for almost two decades (13-26 years). Only three of the 50 men had never met criteria for an additional psychiatric/neurodevelopmental diagnosis and more than half had ongoing comorbidity (most commonly either ADHD or depression or both). Any psychiatric comorbidity increased the risk of poorer outcome. The minority of the AS group who no longer met criteria for a full diagnosis of an autism spectrum disorder were usually free of current psychiatric comorbidity. The high rate of psychiatric/neurodevelopmental comorbidities underscores the need for a full psychiatric/neurodevelopmental assessment at follow-up of males with AS.

  14. [Cystic fibrosis--initial diagnosis in a 39-year-old patient].

    Science.gov (United States)

    Bargon, J; Rickmann, J; Jacobi, V; Straub, R; Arnemann, J; Wagner, T O

    2000-12-15

    Cystic fibrosis is the most common hereditary disorder among Caucasians. Most of the patients are diagnosed as children. However, some cases are going undiagnosed into adulthood and are then often misdiagnosed because the non-pediatricians do not know cystic fibrosis very well and do not consider this diagnosis in adult patients. We present the medical history of a woman, who was diagnosed with cystic fibrosis at the age of 39 years, although she had suffered from bronchiectasis, pancreatic insufficiency and liver cirrhosis since many years. Her medical history was long with some diagnosis, but because of her age nobody considered the final diagnosis. In adult patients with bronchiectasis, liver cirrhosis and pancreatic insufficiency in combination or with only one of these symptoms, cystic fibrosis should be included into the differential diagnosis.

  15. Antibiotic Stewardship Initiatives as Part of the UK 5-Year Antimicrobial Resistance Strategy

    OpenAIRE

    Johnson, Alan P.; Ashiru-Oredope, Diane; Beech, Elizabeth

    2015-01-01

    Antibiotic use is a major driver for the emergence and spread of antibiotic resistance. Antimicrobial stewardship programmes aim to improve antibiotic prescribing with the objectives of optimizing clinical outcomes while at the same time minimizing unintended consequences such as adverse effects and the selection of antibiotic resistance. In 2013, a five-year national strategy for tackling antimicrobial resistance was published in the UK. The overarching goal of the strategy is to slow the de...

  16. Features of tennis methods of teaching 5-6 years old children in the initial stages

    Directory of Open Access Journals (Sweden)

    E.V. Kurmaeva

    2014-06-01

    Full Text Available Purpose : theoretical and methodological justification for the existing teaching methods tennis of 5-6 years old children. Material : 17 special analysis and scientific and methodological sources. Results : the features of the existing methods of teaching children at an early stage of training. The main theses of the existing methods: 1 the training process is carried out in the form of games; 2 the level of general physical preparedness level exceeds special; 3 The first two years of the children do not participate in official competitions; 4 education of children begins with " School Ball ", with a gradual transition to employment with racket and ball; 5 training is built on two levels: theoretical - each " part" in the form of pre- formation of a mental model of rational behavior, and practical - the formation of the ability to perform motor actions. Conclusions : it was found that the existing methods of constructing the training process for children 5-6 years do not account for their physiological characteristics, therefore proposed to use computer technology and animation, that will shorten the formation of motor skills of children.

  17. History of initial fifty years of ARIES: A Major National Indian Facility for Optical Observations

    Science.gov (United States)

    Sanwal, Basant Ballabh; Pandey, Anil Kumar; Uddin, Wahab; Kumar, Brijesh; Joshi, Santosh

    2018-04-01

    The idea of starting an astronomical observatory in the state of Uttar Pradesh in India germinated through the initiative of a scholarly statesman Babu Sampurnanandji. His interest in astrology coupled with his academic bent of mind got him interested in modern astronomy. Being then Education Minister and later Chief Minister of Uttar Pradesh, he established an astronomical observatory at Varanasi on April 20, 1954. Later on it was shifted to Manora Peak, Nainital. Four reflectors were commissioned at Manora Peak. For solar research an H alpha petrol unit and a horizontal solar spectrograph was setup. A detailed project report for installation of a 4-m class optical telescope was prepared indigenously in late 1980, however, the project could not take off. With the generous support of the Department of Science and Technology, the institute established a 3.6-m new technology optical telescope and a 1.3-m wide field optical telescope at a new observing site called Devasthal. Now a 4-m liquid mirror telescope is also being installed at the same observing site. I present here a brief journey of the observatory beginning right from its birth in 1954 till now.

  18. Evaluation of apicultural characteristics of first-year colonies initiated from packaged honey bees (Hymenoptera: Apidae).

    Science.gov (United States)

    Strange, James P; Calderone, Nicholas W

    2009-04-01

    We evaluated the performance of six named types of package honey bees, Apis mellifera L (Hymenoptera: Apidae), from four commercial producers. We examined the effects of levels of the parasitic mite Varroa destructor Anderson & Trueman, the endoparasitic mite Acarapis woodi (Rennie), the gut parasite Nosema (species not determined) in samples from bees in 48 packages, and levels of adult drones in the same packages on corresponding levels of those same traits in the fall in colonies that developed from those 48 packages. After package installation, we measured the rate of queen failure, the removal of freeze-killed brood (an assay to assess hygienic behavior), varroa-sensitive hygiene, and short-term weight gain in all colonies. We examined the correlations among these traits and the effect of initial package conditions and package-type on the expression of these traits. In general, differences among sources were not significant, except that we did observe significant differences in the proportion of mite infected worker brood in the fall. There was no significant difference in weight gain in colonies established from nosema-infected packages versus those established from noninfected packages. Freeze-killed hygienic behavior and varroa-sensitive hygienic behavior were positively correlated, suggesting that both traits could be selected simultaneously. Neither trait was correlated with colony weight gain, suggesting that both traits could be selected without compromising honey production.

  19. Report on the green paper on energy. Four years of European initiatives

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-07-01

    In December 2000, the European Commission adopted a Green Paper on European Union energy policy. This brochure takes stock of the action undertaken in the following areas over the last four years:managing demand, diversifying internal energy sources,developing the internal energy market and the security of external supply. It presents: the Green Paper stakes, the progress made, the four political challenges, managing demand, diversifying European sources, the streamlined internal energy market, controlling external supply, future prospects for the Union, legislative developments and ten possibilities for economical energy use. (A.L.B.)

  20. Report on the green paper on energy. Four years of European initiatives

    International Nuclear Information System (INIS)

    2005-01-01

    In December 2000, the European Commission adopted a Green Paper on European Union energy policy. This brochure takes stock of the action undertaken in the following areas over the last four years:managing demand, diversifying internal energy sources,developing the internal energy market and the security of external supply. It presents: the Green Paper stakes, the progress made, the four political challenges, managing demand, diversifying European sources, the streamlined internal energy market, controlling external supply, future prospects for the Union, legislative developments and ten possibilities for economical energy use. (A.L.B.)

  1. An Unusual Case of Recurrent Guillain-Barre Syndrome of a Different Subtype Five Years after Initial Diagnosis

    Directory of Open Access Journals (Sweden)

    M. Dy

    2013-01-01

    Full Text Available We present a case of a previously healthy 17-year-old girl with history of Guillain-Barre Syndrome 5 years after initial presentation who presented with bilateral lower extremity pain, worsening dysphagia, subsequent weakness, and decreased reflexes. Cerebrospinal fluid analysis had a prominent lymphocytic pleocytosis. MRI of spine showed significant anterior nerve root enhancement. Electromyogram demonstrated a mild axonal greater than demyelinating motor polyneuropathy and intact sensory responses, with no evidence of conduction block or temporal dispersion, unlike her first presentation that revealed a demyelinating polyneuropathy. The patient recovered with mild subjective weakness following 5 days of intravenous immunoglobulin treatment. This case represents a recurrence of a predominantly motor variant polyradiculoneuropathy distinct from the initial presentation with a lymphocytic predominant CSF pleocytosis, nerve root enhancement on MRI spine, and rapid recovery following treatment with intravenous immunoglobulin.

  2. Regional Pediatric Acute Stroke Protocol: Initial Experience During 3 Years and 13 Recanalization Treatments in Children.

    Science.gov (United States)

    Tabone, Laurence; Mediamolle, Nicolas; Bellesme, Celine; Lesage, Fabrice; Grevent, David; Ozanne, Augustin; Naggara, Olivier; Husson, Beatrice; Desguerre, Isabelle; Lamy, Catherine; Denier, Christian; Kossorotoff, Manoelle

    2017-08-01

    To evaluate hyperacute management of pediatric arterial ischemic stroke, setting up dedicated management pathways is the first recommended step to prove the feasibility and safety of such treatments. A regional pediatric stroke alert protocol including 2 centers in the Paris-Ile-de-France area, France, was established. Consecutive pediatric patients (28 days-18 years) with confirmed arterial ischemic stroke who had acute recanalization treatment (intravenous r-tPA [recombinant tissue-type plasminogen activator], endovascular procedure, or both) according to the regional pediatric stroke alert were retrospectively reviewed during a 40-month period. Thirteen children, aged 3.7 to 16.6 years, had recanalization treatment. Median time from onset to magnetic resonance imaging was 165 minutes (150-300); 9 out of 13 had large-vessel occlusion. Intravenous r-tPA was used in 11 out of 13 patients, with median time from onset to treatment of 240 minutes (178-270). Endovascular procedure was performed in patients time-out for intravenous r-tPA (n=2) or after intravenous r-tPA inefficiency (n=2). No intracranial or peripheral bleeding was reported. One patient died of malignant stroke; outcome was favorable in 11 out of 12 survivors (modified Rankin Scale score 0-2). Hyperacute recanalization treatment in pediatric stroke, relying on common protocols and adult/pediatric ward collaboration, is feasible. Larger systematic case collection is encouraged. © 2017 American Heart Association, Inc.

  3. Consecutive operative procedures in patients with Marfan syndrome up to 28 years after initial aortic root surgery.

    Science.gov (United States)

    Puluca, Nazan; Burri, Melchior; Cleuziou, Julie; Krane, Markus; Lange, Rüdiger

    2018-02-28

    Most patients (75%) with Marfan syndrome present with aortic root dilatation that may require surgical intervention. However, associated cardiovascular disorders are not limited to the aortic root. These patients frequently require consecutive operations on the remaining thoracic aorta or the heart valves. Our intent was to characterize the spectrum of such procedures. Data from all patients with Marfan syndrome undergoing aortic root surgery at our centre between 1988 and 2016 were analysed retrospectively. Overall, 73 patients (26 women) were selected for the study. The median age at 1st operation was 30 years (3-68 years). Indications for aortic root surgery were aneurysm (78%) and dissection (22%). Initially, 33 Bentall procedures and 40 valve-sparing root replacement procedures were performed, with a 97% rate of follow-up completion. The median follow up was 8 years (0-28 years). Survival at 1, 10 and 15 years was 100%, 85% and 82%, respectively. During follow-up monitoring, 48 subsequent procedures were performed in 33 patients (aorta, 23; aortic valve, 11; mitral valve, 7 and combined procedures, 7). The 30-day mortality rate after subsequent procedures was 4.2%. Freedom from subsequent operation and death (combined end-point) after 5, 10 and 15 years was 70%, 53% and 34%, respectively. After the initial surgery, subsequent procedures required in the setting of Marfan syndrome most often involve the remaining native aorta, followed by the aortic and mitral valves. The continued need for additional operative procedures remains high, even decades after the initial surgeries are undertaken. Therefore, long-term patient monitoring at specialized centres is imperative.

  4. Antibiotic Stewardship Initiatives as Part of the UK 5-Year Antimicrobial Resistance Strategy

    Directory of Open Access Journals (Sweden)

    Alan P. Johnson

    2015-10-01

    Full Text Available Antibiotic use is a major driver for the emergence and spread of antibiotic resistance. Antimicrobial stewardship programmes aim to improve antibiotic prescribing with the objectives of optimizing clinical outcomes while at the same time minimizing unintended consequences such as adverse effects and the selection of antibiotic resistance. In 2013, a five-year national strategy for tackling antimicrobial resistance was published in the UK. The overarching goal of the strategy is to slow the development and spread of resistance and to this end it has three strategic aims, namely to improve knowledge and understanding of resistance, to conserve and steward the effectiveness of existing treatments and to stimulate the development of new antibiotics, diagnostics and novel therapies. This article reviews the antimicrobial stewardship activities included in the strategy and describes their implementation and evaluation.

  5. X-linked adrenoleukodystrophy in a 6-year-old boy initially presenting with psychiatric symptoms.

    Science.gov (United States)

    İncecik, Faruk; Hergüner, M Özlem; Mert, Gülen; Önenli-Mungan, Neslihan; Ceylaner, Serdar; Kör, Deniz; Altunbaşak, Şakir

    2014-01-01

    X-linked adrenoleukodystrophy (ALD) leads to demyelination of the nervous system, adrenal insufficiency and accumulation of long-chain fatty acids. Most young patients with X-linked ALD develop seizures and progressive neurologic deficits, and die within the first two decades of life. We present the case of a 6-year-old with childhood-onset ALD, first presenting with psychiatric symptoms and progressive gait difficulties, slurred speech and cognitive impairment. Genetic testing was performed and a p.R401Q (c.1202G>A) mutation detected in the ABCD1 gene. ALD should be considered in the differential diagnosis of patients presenting with behavior changes and white matter disease in neuroimaging.

  6. Increasing Universal Lipid Screening Among 9- to 11-Year-Old Children Through a Quality Improvement Initiative.

    Science.gov (United States)

    Kern, Leah; Crow, Janet; Williams, Christine B; Boies, Eyla; Gahagan, Sheila; Rhee, Kyung E

    2017-06-01

    In 2011, the National Heart Lung and Blood Institute recommended universal lipid screening (ULS) in 9- to 11-year-old children. This study aimed to determine whether a quality improvement (QI) initiative increased ULS. Data were abstracted from the electronic medical record to compare screening behaviors 1 year preimplementation and postimplementation. A focus group was conducted to examine physicians' attitudes. In preimplementation and postimplementation years, the number of 9- to 11-year-olds seen for well-child checks were 356 and 357, respectively. The first and second phases of the intervention were associated with a 64.3% ( P health. More research on the benefits, costs, and outcomes of ULS is needed.

  7. Long-term outcome of infective endocarditis: A study on patients surviving over one year after the initial episode treated in a Finnish teaching hospital during 25 years

    Directory of Open Access Journals (Sweden)

    Engblom Erik

    2008-04-01

    Full Text Available Abstract Background Only a few previous studies have focused on the long-term prognosis of the patients with infective endocarditis (IE. Our purpose was to delineate factors potentially associated with the long-term outcome of IE, recurrences of IE and requirement for late valve surgery. Methods A total of 326 episodes of IE in 303 patients were treated during 1980–2004 in the Turku University Hospital. We evaluated the long-term outcome and requirement for late valve surgery for 243 of these episodes in 226 patients who survived longer than 1 year after the initial admission. Factors associated with recurrences were analysed both for the 1-year survivors and for all 303 patients. Results The mean (SD follow-up time for the 1-year survivors was 11.5 (7.3 years (range 25 days to 25.5 years. The overall survival was 95%, 82%, 66%, 51% and 45% at 2, 5, 10, 15 and 20 years. In age and sex adjusted multivariate analyses, significant predictors for long-term overall mortality were heart failure within 3 months of admission (HR 1.97, 95% CI 1.27 to 3.06; p = 0.003 and collagen disease (HR 2.54, 95% CI 1.25 to 5.19; p = 0.010 or alcohol abuse (HR 2.39, 95% CI 1.30 to 4.40; p = 0.005 as underlying conditions, while early surgery was significantly associated with lower overall mortality rates (HR 0.31, 95% CI 0.17 to 0.58; p Conclusion Heart failure during the index episode of IE was the complication, which significantly predicted a poor long-term outcome. Patients who underwent surgery during the initial hospitalisation for IE faired significantly better than those who did not.

  8. Addressing culture shock in first year midwifery students: Maximising the initial clinical experience.

    Science.gov (United States)

    Cummins, Allison M; Catling, Christine; Hogan, Rosemarie; Homer, Caroline S E

    2014-12-01

    Many Bachelor of Midwifery students have not had any exposure to the hospital setting prior to their clinical placement. Students have reported their placements are foreign to them, with a specialised confusing 'language'. It is important to provide support to students to prevent culture shock that may lead to them leaving the course. To assist first year midwifery students with the transition into clinical practice by providing a preparatory workshop. An action research project developed resources for a workshop held prior to students' first clinical placement. Four phases were held: Phase one involved holding discussion groups with students returning from clinical practice; Phase two was the creation of vodcasts; Phase three was integration of resources into the clinical subject and phase four was the evaluation and reflection on the action research project. Evaluations of the workshops were undertaken through surveying the students after they returned from their clinical placement. A descriptive analysis of the evaluations was performed. Students rated the workshop, vodcasts and the simulated handover positively. Further recommendations were that complications of labour and birth be included in their first semester as students were unexpectedly exposed to this in their first clinical placement. The students evaluated the workshop positively in reducing the amount of culture shock experienced on the first clinical placement. In addition the students provided further recommendations of strategies that would assist with clinical placement. Copyright © 2014 Australian College of Midwives. Published by Elsevier Ltd. All rights reserved.

  9. An initial ULF wave index derived from 2 years of Swarm observations

    Science.gov (United States)

    Papadimitriou, Constantinos; Balasis, Georgios; Daglis, Ioannis A.; Giannakis, Omiros

    2018-03-01

    The ongoing Swarm satellite mission provides an opportunity for better knowledge of the near-Earth electromagnetic environment. Herein, we use a new methodological approach for the detection and classification of ultra low-frequency (ULF) wave events observed by Swarm based on an existing time-frequency analysis (TFA) tool and utilizing a state-of-the-art high-resolution magnetic field model and Swarm Level 2 products (i.e., field-aligned currents - FACs - and the Ionospheric Bubble Index - IBI). We present maps of the dependence of ULF wave power with magnetic latitude and magnetic local time (MLT) as well as geographic latitude and longitude from the three satellites at their different locations in low-Earth orbit (LEO) for a period spanning 2 years after the constellation's final configuration. We show that the inclusion of the Swarm single-spacecraft FAC product in our analysis eliminates all the wave activity at high altitudes, which is physically unrealistic. Moreover, we derive a Swarm orbit-by-orbit Pc3 wave (20-100 MHz) index for the topside ionosphere and compare its values with the corresponding variations of solar wind variables and geomagnetic activity indices. This is the first attempt, to our knowledge, to derive a ULF wave index from LEO satellite data. The technique can be potentially used to define a new Level 2 product from the mission, the Swarm ULF wave index, which would be suitable for space weather applications.

  10. ICU Patients Requiring Renal Replacement Therapy Initiation: Fewer Survivors and More Dialysis Dependents From 80 Years Old.

    Science.gov (United States)

    Commereuc, Morgane; Guérot, Emmanuel; Charles-Nelson, Anais; Constan, Adrien; Katsahian, Sandrine; Schortgen, Frédérique

    2017-08-01

    To assess the role of advanced age on survival and dialysis dependency after initiation of renal replacement therapy for acute kidney injury. Retrospective pooled analysis of prospectively collected data. ICUs of two teaching hospitals in Paris area, France. One thousand five hundred thirty adult patients who required renal replacement therapy initiation in the ICU. None. Survival and post acute kidney injury chronic dialysis dependency were assessed at hospital discharge according to the quintile (Q) of age. The oldest quintile included 289 patients 80 years old and over. Seventy-three percent of included patients had respiratory and hemodynamic supports at renal replacement therapy initiation, similarly distributed across quintiles. Mortality increased with age strata from 63% in Q1 (≤ 52 yr) to 76% in Q5 (≥ 80 yr) (p patients (≥ 80 yr) had a significant higher risk of dying (adjusted odds ratio, 2.59; 95% CI, 1.66-4.03). Dialysis dependency was more frequent among survivors 80 years old or older (30% vs 14%; p = 0.001). Age 80 years old or older was an independent risk for dialysis dependency only for patients with prior advanced chronic kidney disease (p = 0.04). Baseline estimated glomerular filtration rate was the only one predictor of dialysis dependency identified. Patients with advanced age represent a substantial subgroup of patients requiring renal replacement therapy in the ICU. From 80 years, age should be considered as an additional risk of dying over the severity of organ failures. Patients 80 years old or older are likely to recover sufficient renal function allowing renal replacement therapy discontinuation when baseline estimated glomerular filtration rate is above 44 mL/min/1.73 m. At 3 months, only 6% were living at home, dialysis independent.

  11. Polarization developments

    International Nuclear Information System (INIS)

    Prescott, C.Y.

    1993-07-01

    Recent developments in laser-driven photoemission sources of polarized electrons have made prospects for highly polarized electron beams in a future linear collider very promising. This talk discusses the experiences with the SLC polarized electron source, the recent progress with research into gallium arsenide and strained gallium arsenide as a photocathode material, and the suitability of these cathode materials for a future linear collider based on the parameters of the several linear collider designs that exist

  12. What makes for sustainable Healthy Cities initiatives?--A review of the evidence from Noarlunga, Australia after 18 years.

    Science.gov (United States)

    Baum, Fran; Jolley, Gwyneth; Hicks, Richard; Saint, Kate; Parker, Steve

    2006-12-01

    This paper examines the factors that have enabled the Healthy Cities Noarlunga (HCN) initiative to be sustainable over 18 years (1987-2005). Sustainability related to the ability of the initiative to continue to operate continuously in a manner that indicated its existence was accorded value by the community and local service providers. The analysis is based on a narrative review of 29 documents related to HCN, including a number of evaluations. Nine factors emerged as important to ensuring sustainability: strong social health vision; inspirational leadership; a model that can adapt to local conditions; ability to juggle competing demands; strongly supported community involvement that represents genuine engagement; recognition by a broad range of players that Healthy Cities is a relatively neutral space in which to achieve goals; effective and sustainable links with a local university; an outward focus open to international links and outside perspectives; and, most crucial, the initiative makes the transition from a project to an approach and a way of working. These sustainability factors are likely to be relevant to a range of complex, community-based initiatives.

  13. Orbitofrontal volumes in early adolescence predict initiation of cannabis use: a 4-year longitudinal and prospective study.

    Science.gov (United States)

    Cheetham, Ali; Allen, Nicholas B; Whittle, Sarah; Simmons, Julian G; Yücel, Murat; Lubman, Dan I

    2012-04-15

    There is growing evidence that long-term, heavy cannabis use is associated with alterations in regional brain volumes. Although these changes are frequently attributed to the neurotoxic effects of cannabis, it is possible that some abnormalities might predate use and represent markers of vulnerability. To date, no studies have examined whether structural brain abnormalities are present before the onset of cannabis use. This study aims to determine whether adolescents who have initiated cannabis use early (i.e., before age 17 years) show premorbid structural abnormalities in the amygdala, hippocampus, orbitofrontal cortex, and anterior cingulate cortex. Participants (n = 121) were recruited from primary schools in Melbourne, Australia, as part of a larger study examining adolescent emotional development. Participants underwent structural magnetic resonance imaging at age 12 years and were assessed for cannabis use 4 years later, at age 16 years. At the follow-up assessment, 28 participants had commenced using cannabis (16 female subjects [57%]), and 93 had not (43 female subjects [46%]). Smaller orbitofrontal cortex volumes at age 12 years predicted initiation of cannabis use by age 16 years. The volumes of other regions (amygdala, hippocampus, and anterior cingulate cortex) did not predict later cannabis use. These findings suggest that structural abnormalities in the orbitofrontal cortex might contribute to risk for cannabis exposure. Although the results have important implications for understanding neurobiological predictors of cannabis use, further research is needed to understand their relationship with heavier patterns of use in adulthood as well as later abuse of other substances. Copyright © 2012 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

  14. Extravehicular Activity Systems Education and Public Outreach in Support of NASA's STEM Initiatives in Fiscal Year 2011

    Science.gov (United States)

    Paul, Heather; Jennings, Mallory A.; Lamberth, Erika Guillory

    2012-01-01

    NASA's goals to send humans beyond low Earth orbit will involve the need for a strong engineering workforce. Research indicates that student interest in science, technology, engineering, and math (STEM) areas is on the decline. According to the Department of Education, the United States President has mandated that 100,000 educators be trained in STEM over the next decade to reduce this trend. NASA has aligned its Education and Public Outreach (EPO) initiatives to include emphasis in promoting STEM. The Extravehicular Activity (EVA) Systems Project Office at the NASA Johnson Space Center actively supports this NASA initiative by providing subject matter experts and hands-on, interactive presentations to educate students, educators, and the general public about the design challenges encountered as NASA develops EVA hardware for exploration missions. This paper summarizes the EVA Systems EPO efforts and metrics from fiscal year 2011.

  15. Three-tiered support: Individual, school and institution-wide initiatives through a first year advisor network through a first year advisor network

    Directory of Open Access Journals (Sweden)

    Helen Kemp

    2013-08-01

    Full Text Available The First Year Advisor Network (FYAN at Murdoch University has a three-tiered approach offering (i individual, (ii school-based and (iii institution-wide student access to support that addresses the diverse needs of the contemporary student population. The programs, campaigns and open-door policy of the FYAN, along with the unique structure of the network, have been developed to provide these varied points of access to student support. Importantly, First Year Advisors (FYAs act as a generalised support for all students and as a hub to accessing specialised support at the University. This paper highlights the range of initiatives developed by the FYAN and emphasises that while outreach contact is a successful way to promote access to support, many students still self identify as at-risk and will access FYAs for direct and referral advice.

  16. The polar year starts in March. Arctics promises. When the North path will be opened to maritime traffic

    International Nuclear Information System (INIS)

    Lepetit, V.; Remoue, A.

    2007-01-01

    From Greenland to Alaska and from the Barents sea to the Okhotsk sea, oil companies are performing exploratory drillings looking for the North pole black gold. Far away from being an utopia, this new conquest of the great north is organizing yet. The Arctic hydrocarbon reserves may represent 10% of the world reserves. Moreover, with the increasing melting of ice sheets, the Arctic path will be opened to navigation and exploration in less than 25 years. The great north territories are shared between eight countries (USA, Canada, Denmark, Island, Norway, Sweden, Finland and Russia) and leads to disputes about the limits of territorial waters. (J.S.)

  17. Polarization, political

    NARCIS (Netherlands)

    Wojcieszak, M.; Mazzoleni, G.; Barnhurst, K.G.; Ikeda, K.; Maia, R.C.M.; Wessler, H.

    2015-01-01

    Polarization has been studied in three different forms: on a social, group, and individual level. This entry first focuses on the undisputed phenomenon of elite polarization (i.e., increasing adherence of policy positions among the elites) and also outlines different approaches to assessing mass

  18. RHIC Polarized proton operation

    International Nuclear Information System (INIS)

    Huang, H.; Ahrens, L.; Alekseev, I.G.; Aschenauer, E.; Atoian, G.; Bai, M.; Bazilevsky, A.; Blaskiewicz, M.; Brennan, J.M.; Brown, K.A.; Bruno, D.; Connolly, R.; Dion, A.; D'Ottavio, T.; Drees, K.A.; Fischer, W.; Gardner, C.; Glenn, J.W.; Gu, X.; Harvey, M.; Hayes, T.; Hoff, L.; Hulsart, R.L.; Laster, J.; Liu, C.; Luo, Y.; MacKay, W.W.; Makdisi, Y.; Marr, G.J.; Marusic, A.; Meot, F.; Mernick, K.; Michnoff, R.; Minty, M.; Montag, C.; Morris, J.; Nemesure, S.; Poblaguev, A.; Ptitsyn, V.; Ranjibar, V.; Robert-Demolaize, G.; Roser, T.; Schmidke, B.; Schoefer, V.; Severino, F.; Smirnov, D.; Smith, K.; Steski, D.; Svirida, D.; Tepikian, S.; Trbojevic, D.; Tsoupas, N.; Tuozzolo, J.E.; Wang, G.; Wilinski, M.; Yip, K.; Zaltsman, A.; Zelenski, A.; Zeno, K.; Zhang, S.Y.

    2011-01-01

    The Relativistic Heavy Ion Collider (RHIC) operation as the polarized proton collider presents unique challenges since both luminosity(L) and spin polarization(P) are important. With longitudinally polarized beams at the experiments, the figure of merit is LP 4 . A lot of upgrades and modifications have been made since last polarized proton operation. A 9 MHz rf system is installed to improve longitudinal match at injection and to increase luminosity. The beam dump was upgraded to increase bunch intensity. A vertical survey of RHIC was performed before the run to get better magnet alignment. The orbit control is also improved this year. Additional efforts are put in to improve source polarization and AGS polarization transfer efficiency. To preserve polarization on the ramp, a new working point is chosen such that the vertical tune is near a third order resonance. The overview of the changes and the operation results are presented in this paper. Siberian snakes are essential tools to preserve polarization when accelerating polarized beams to higher energy. At the same time, the higher order resonances still can cause polarization loss. As seen in RHIC, the betatron tune has to be carefully set and maintained on the ramp and during the store to avoid polarization loss. In addition, the orbit control is also critical to preserve polarization. The higher polarization during this run comes from several improvements over last run. First we have a much better orbit on the ramp. The orbit feedback brings down the vertical rms orbit error to 0.1mm, much better than the 0.5mm last run. With correct BPM offset and vertical realignment, this rms orbit error is indeed small. Second, the jump quads in the AGS improved input polarization for RHIC. Third, the vertical tune was pushed further away from 7/10 snake resonance. The tune feedback maintained the tune at the desired value through the ramp. To calibrate the analyzing power of RHIC polarimeters at any energy above

  19. RHIC Polarized proton operation

    Energy Technology Data Exchange (ETDEWEB)

    Huang, H.; Ahrens, L.; Alekseev, I.G.; Aschenauer, E.; Atoian, G.; Bai, M.; Bazilevsky, A.; Blaskiewicz, M.; Brennan, J.M.; Brown, K.A.; Bruno, D.; Connolly, R.; Dion, A.; D' Ottavio, T.; Drees, K.A.; Fischer, W.; Gardner, C.; Glenn, J.W.; Gu, X.; Harvey, M.; Hayes, T.; Hoff, L.; Hulsart, R.L.; Laster, J.; Liu, C.; Luo, Y.; MacKay, W.W.; Makdisi, Y.; Marr, G.J.; Marusic, A.; Meot, F.; Mernick, K.; Michnoff, R,; Minty, M.; Montag, C.; Morris, J.; Nemesure, S.; Poblaguev, A.; Ptitsyn, V.; Ranjibar, V.; Robert-Demolaize, G.; Roser, T.; J.; Severino, F.; Schmidke, B.; Schoefer, V.; Severino, F.; Smirnov, D.; Smith, K.; Steski, D.; Svirida, D.; Tepikian, S.; Trbojevic, D.; Tsoupas, N.; Tuozzolo, J. Wang, G.; Wilinski, M.; Yip, K.; Zaltsman, A.; Zelenski, A.; Zeno, K.; Zhang, S.Y.

    2011-03-28

    The Relativistic Heavy Ion Collider (RHIC) operation as the polarized proton collider presents unique challenges since both luminosity(L) and spin polarization(P) are important. With longitudinally polarized beams at the experiments, the figure of merit is LP{sup 4}. A lot of upgrades and modifications have been made since last polarized proton operation. A 9 MHz rf system is installed to improve longitudinal match at injection and to increase luminosity. The beam dump was upgraded to increase bunch intensity. A vertical survey of RHIC was performed before the run to get better magnet alignment. The orbit control is also improved this year. Additional efforts are put in to improve source polarization and AGS polarization transfer efficiency. To preserve polarization on the ramp, a new working point is chosen such that the vertical tune is near a third order resonance. The overview of the changes and the operation results are presented in this paper. Siberian snakes are essential tools to preserve polarization when accelerating polarized beams to higher energy. At the same time, the higher order resonances still can cause polarization loss. As seen in RHIC, the betatron tune has to be carefully set and maintained on the ramp and during the store to avoid polarization loss. In addition, the orbit control is also critical to preserve polarization. The higher polarization during this run comes from several improvements over last run. First we have a much better orbit on the ramp. The orbit feedback brings down the vertical rms orbit error to 0.1mm, much better than the 0.5mm last run. With correct BPM offset and vertical realignment, this rms orbit error is indeed small. Second, the jump quads in the AGS improved input polarization for RHIC. Third, the vertical tune was pushed further away from 7/10 snake resonance. The tune feedback maintained the tune at the desired value through the ramp. To calibrate the analyzing power of RHIC polarimeters at any energy above

  20. Polar Bears

    Science.gov (United States)

    Amstrup, Steven C.; Douglas, David C.; Reynolds, Patricia E.; Rhode, E.B.

    2002-01-01

    Polar bears (Ursus maritimus) are hunted throughout most of their range. In addition to hunting polar bears of the Beaufort Sea region are exposed to mineral and petroleum extraction and related human activities such as shipping road-building, and seismic testing (Stirling 1990).Little was known at the start of this project about how polar bears move about in their environment, and although it was understood that many bears travel across political borders, the boundaries of populations had not been delineated (Amstrup 1986, Amstrup et al. 1986, Amstrup and DeMaster 1988, Garner et al. 1994, Amstrup 1995, Amstrup et al. 1995, Amstrup 2000).As human populations increase and demands for polar bears and other arctic resources escalate, managers must know the sizes and distributions of the polar bear populations. Resource managers also need reliable estimates of breeding rates, reproductive intervals, litter sizes, and survival of young and adults.Our objectives for this research were 1) to determine the seasonal and annual movements of polar bears in the Beaufort Sea, 2) to define the boundaries of the population(s) using this region, 3) to determine the size and status of the Beaufort Sea polar bear population, and 4) to establish reproduction and survival rates (Amstrup 2000).

  1. Political terrorism and affective polarization in "black" and "red" terrorists in Italy during the years 1968-1988.

    Science.gov (United States)

    Pacini, Matteo; Maremmani, Icro

    2018-04-01

    Psychiatric evaluations of violent political crime were mostly performed on a case-by-case basis in a forensic environment, which made them unduly dependent on categories of presumed dangerousness and legal responsibility, rather than on a clinical definition of their mental status. In referring to such "clinical" definitions, the disorder we have in mind is not limited to the major, agitated psychotic manias or mixed states. The presence of a dominant temperament, or protracted hypomania, is enough by itself to explain an individual's engagement in a wide range of activities, not necessarily sociopathic or violent. We put forward the hypothesis that formal and transpolitical radical choices, either in favor of an illegal lifestyle or of activities involving a high level of risk, may be linked with certain mental states, especially when considering small clandestine groups showing a high level of internal ideological consensus, and a no-return attitude toward a commitment to radical choices. Available data about the psycho(patho)logical profile of terrorists are still hard to come by. The only available studies are those on identified living terrorists (judging by the trials of those who personally admitted to having been terrorists), and statistical data imply a number of documented cases belonging to the same terrorist organization. In Italy, the period often called the "years of lead [bullets]" displays an interesting viewpoint for the study of terrorist psychology, for two main reasons: first of all, it is a historically defined period (1968-1988), and second, the number of ascertained participants in terrorist activities was quite large.

  2. Polare maskuliniteter

    Directory of Open Access Journals (Sweden)

    Marit Anne Hauan

    2012-05-01

    Full Text Available In this paper my aim is to read and understand the journal of Gerrit de Veer from the last journey of William Barents to the Arctic Regions in 1596 and the journal of captain Junge on his hunting trip from Tromsø to Svalbard in 1834.It is nearly 240 years between this to voyages. The first journal is known as the earliest report from the arctic era. Gerrit de Veer adds instructive copper engravings to his text and give us insight in the crews meeting with this new land. Captain Junges journal is found together with his dead crew in a house in a fjord nearby Ny-Ålesund and has no drawings, but word. Both of these journals may be read as sources of the knowledge and understanding of the polar region. They might also unveil the ideas of how to deal with and survive under the challenges that is given. In addition one can ask if the sources can tell us more about how men describe their challenges. Can the way they expressed themselves in the journals give us an understanding of masculinity? And not least help us to create good questions of the change in the ideas of masculinities which is said to follow the change in understanding of the wilderness.

  3. Report of the first three years of the initiative in accelerator R and D for particle physics

    CERN Document Server

    Norton, P

    2002-01-01

    The 'Particle Accelerators for Particle Physics' initiative was jointly funded by PPARC and CCLRC for three years, starting in 1999. The main objective was to re-create and re-establish within the UK the tradition of research and development into accelerator technology for particle physics applications, either at the high energy or the high luminosity frontier. This would enable the UK to evaluate for itself how it would wish to contribute to future international particle physics facilities, with the option of making the contribution to the machine 'in kind' (as is done with the detectors). The major international particle physics laboratories (CERN, DESY, FNAL, SLAC) with whom the UK particle physics community has worked over the past twenty years warmly welcomed this initiative. The scientific case for the next generation of facilities beyond the LHC, HERA, the B-factories and the Tevatron is now well developed. There is general agreement, underlined by the OECD Global Science Forum report by the Consultati...

  4. Anti-osteoporotic treatments in France: initiation, persistence and switches over 6 years of follow-up.

    Science.gov (United States)

    Belhassen, M; Confavreux, C B; Cortet, B; Lamezec, L; Ginoux, M; Van Ganse, E

    2017-03-01

    Limited information is available on anti-osteoporotic treatment initiation patterns in France. In 2006-2013, the most frequently prescribed first-line treatment class for osteoporosis was represented by bisphosphonates (alendronic acid and risedronic acid), followed by strontium ranelate. Persistence with anti-osteoporotic treatment was low, with high proportions of treatment discontinuations and switches. This epidemiological, longitudinal study described first-line treatment initiation, persistence, switches to second-line treatment, and medical care consumption in osteoporotic patients in France during the 2007-2013 period. Patients aged ≥50 years, who were recorded in a French claims database and did not die during the observation period, were included if they met ≥1 inclusion criteria for osteoporosis in 2007 (≥1 reimbursement for anti-osteoporotic treatment, hospitalisation for osteoporotic fracture (spine, hip, femur, forearm bones, humerus, wrist), or ≥1 reimbursement for long-term osteoporosis-associated status). We collected data on consumption of anti-osteoporotic treatment (alendronic acid, ibandronic acid, risedronic acid, zoledronic acid, raloxifene, strontium ranelate, teriparatide) and of osteoporosis-related medical care after the date of first reimbursement for anti-osteoporotic treatment. We obtained 2219 patients with a 6-year follow-up and 1387 who initiated an anti-osteoporotic treatment in 2007 and who can be selected for the treatment regimen analysis. The most frequently used first-line treatments were alendronic acid (32.7 %), risedronic acid (22.4 %), strontium ranelate (19.3 %), ibandronic acid (13.1 %) and raloxifene (12.2 %). Among patients who received these treatments, the highest persistence after 6 years was observed for raloxifene (37.3 %), alendronic acid (35.1 %) and risedronic acid (32.3 %). Treatment discontinuations were reported for 35.5 % (raloxifene) to 53.4 % (strontium ranelate) and treatment switches

  5. Trends over 8 years in quality of diabetes care: results of the AMD Annals continuous quality improvement initiative.

    Science.gov (United States)

    Rossi, Maria Chiara; Candido, Riccardo; Ceriello, Antonio; Cimino, Antonino; Di Bartolo, Paolo; Giorda, Carlo; Esposito, Katherine; Lucisano, Giuseppe; Maggini, Marina; Mannucci, Edoardo; Meloncelli, Illidio; Nicolucci, Antonio; Pellegrini, Fabio; Scardapane, Marco; Vespasiani, Giacomo

    2015-06-01

    Quality of care monitoring is a key strategy for health policy. In Italy, the AMD Annals continuous monitoring and quality improvement initiative has been in place since 2006. Results after 8 years are now available. Quality of diabetes care indicators during the years 2004-2011 were extracted from electronic medical records of 300 diabetes clinics. From 200,000 to 500,000 patients with type 2 diabetes were analyzed per year. Six process indicators, eight intermediate outcome indicators, seven indicators of treatment intensity/appropriateness, and a quality of care summary score (Q score) were evaluated. Previous studies documented that the risk of developing a new cardiovascular event was 80 % higher in patients with a Q score 25. The proportion of patients with HbA1c ≤7 %, LDL cholesterol 25 increased from 22.9 to 38.5 %. AMD Annals document the progress in quality of diabetes care. Longitudinal improvements in Q score can translate into less cardiovascular events, with evident clinical and economic implications. AMD Annals represent a physician-led effort not requiring allocation of extra-economic resources, which is easy to implement and deeply rooted in routine clinical practice. They are a potential case model for other healthcare systems.

  6. Confidence Demonstrated by Students of Pedagogy on the Teaching of Astronomy in the Initial Years of the Elementary School

    Science.gov (United States)

    Welington, Cerqueira, Jr.; dos Santos Almeida, Robenil; do Santos da Conceição, Regiane; Dutra, Glênon

    2015-12-01

    This work attempts to identify the level of confidence of some students of the course in Pedagogy of a public University located in the interior of the Bahia state, for the teaching of contents of Astronomy in the initial years of the Elementary School. The data was obtained from the application of a questionnaire, answered by 16 students. The analysis of these results took into account several factors, like the framework of the curriculum of the graduation course in Pedagogy, the reading profile of the students and the level of experience regarding their teaching in classroom. The obtained results point to a great insecurity of the students regarding the teaching of contents of Astronomy, being compatible with previous findings of other investigators of the area.

  7. Polarized protons at RHIC

    International Nuclear Information System (INIS)

    Tannenbaum, M.J.

    1990-12-01

    The Physics case is presented for the use of polarized protons at RHIC for one or two months each year. This would provide a facility with polarizations of approx-gt 50% high luminosity ∼2.0 x 10 32 cm -2 s -1 , the possibility of both longitudinal and transverse polarization at the interaction regions, and frequent polarization reversal for control of systematic errors. The annual integrated luminosity for such running (∼10 6 sec per year) would be ∫ Ldt = 2 x 10 38 cm -2 -- roughly 20 times the total luminosity integrated in ∼ 10 years of operation of the CERN Collider (∼10 inverse picobarns, 10 37 cm -2 ). This facility would be unique in the ability to perform parity-violating measurements and polarization test of QCD. Also, the existence of p-p collisions in a new energy range would permit the study of ''classical'' reactions like the total cross section and elastic scattering, etc., and serve as a complement to measurements from p-bar p colliders. 11 refs

  8. WHO European Childhood Obesity Surveillance Initiative: body mass index and level of overweight among 6-9-year-old children from school year 2007/2008 to school year 2009/2010.

    LENUS (Irish Health Repository)

    Wijnhoven, Trudy Ma

    2014-01-01

    The World Health Organization (WHO) Regional Office for Europe has established the Childhood Obesity Surveillance Initiative (COSI) to monitor changes in overweight in primary-school children. The aims of this paper are to present the anthropometric results of COSI Round 2 (2009\\/2010) and to explore changes in body mass index (BMI) and overweight among children within and across nine countries from school years 2007\\/2008 to 2009\\/2010.

  9. Initial years of recreational artistic gymnastics training improves lumbar spine bone mineral accrual in 4- to 8-year-old females.

    Science.gov (United States)

    Laing, Emma M; Wilson, Alissa R; Modlesky, Christopher M; O'Connor, Patrick J; Hall, Daniel B; Lewis, Richard D

    2005-03-01

    Gymnasts' bone mineral characteristics are generally not known before starting their sport. Prepubertal females who enrolled in beginning artistic gymnastics (n = 65) had lower bone mineral than controls (n = 78). However, 2 years of gymnastics participation versus no participation led to a significantly greater accrual of forearm bone area and lumbar spine areal BMD. The skeletal response to exercise in children compared with adults is heightened because of the high bone turnover rate and the ability of bone to change its size and shape. Whereas child gymnasts generally have greater rates of bone mineral accrual compared with nongymnasts, it is unknown if some of these skeletal advantages are present before the onset of training or are caused entirely by training. Changes in bone area (BA; cm2), BMC (g), and areal BMD (aBMD; g/cm2) over 24 months were examined in prepubertal females, 4-8 years of age, who selected to perform recreational gymnastics (GYM; n = 65), nongymnastic activities, or no organized activity (CON; n = 78). Participants had essentially no lifetime history of organized athletic participation ( 0.05). Controlling for differences in race, baseline measures of body mass, height, and calcium intake, and change in breast development beyond stage II at 24 months, GYM had greater long-term (asymptotic) mean responses for total body aBMD and forearm BMC (p < 0.04) and greater rates of increase in the mean responses of lumbar spine aBMD and forearm BA compared with CON over 24 months. Over time, forearm BA increased to a greater extent in HLG compared with LLG (p < 0.01). Females participating in recreational gymnastics initiated during childhood have enhanced bone mineral gains at the total body, lumbar spine, and forearm over 24 months. Higher-level training promotes additional gains in forearm BA.

  10. A new Arctic 25-year Altimetric Sea-level Record (1992-2016) and Initial look at Arctic Sea Level Budget Closure

    OpenAIRE

    Andersen O.B., Passaro M., Benveniste J., Piccioni G.

    2016-01-01

    A new initiative within the ESA Sea Level Climate Change initiative (SL-cci) framework to improve the Arctic sea level record has been initiated as a combined effort to reprocess and retrack past altimetry to create a 25-year combined sea level record for sea level research studies. One of the objectives is to retracked ERS-2 dataset for the high latitudes based on the ALES retracking algorithm through adapting the ALES retracker for retracking of specular surfaces (leads). Secondly a reproce...

  11. Political polarization

    OpenAIRE

    Dixit, Avinash K.; Weibull, Jörgen W.

    2007-01-01

    Failures of government policies often provoke opposite reactions from citizens; some call for a reversal of the policy, whereas others favor its continuation in stronger form. We offer an explanation of such polarization, based on a natural bimodality of preferences in political and economic contexts and consistent with Bayesian rationality.

  12. Political polarization.

    Science.gov (United States)

    Dixit, Avinash K; Weibull, Jörgen W

    2007-05-01

    Failures of government policies often provoke opposite reactions from citizens; some call for a reversal of the policy, whereas others favor its continuation in stronger form. We offer an explanation of such polarization, based on a natural bimodality of preferences in political and economic contexts and consistent with Bayesian rationality.

  13. State-to-state photodissociation of carbonyl sulfide (ν2=0,1|JlM). II. The effect of initial bending on coherence of S(1D2) polarization

    International Nuclear Information System (INIS)

    Brom, Alrik J. van den; Rakitzis, T. Peter; Janssen, Maurice H. M.

    2005-01-01

    Photodissociation studies using ion imaging are reported, measuring the coherence of the polarization of the S( 1 D 2 ) fragment from the photolysis of single-quantum state-selected carbonyl sulfide (OCS) at 223 and 230 nm. A hexapole state-selector focuses a molecular beam of OCS parent molecules in the ground state (ν 2 =0 vertical bar JM=10) or in the first excited bending state (ν 2 =1 vertical bar JlM=111). At 230 nm photolysis the Im[a 1 (1p arallel ,perpendicular )] moment for the fast S( 1 D 2 ) channel increases by about 50% when the initial OCS parent state changes from the vibrationless ground state to the first excited bending state. No dependence on the initial bending state is found for photolysis at 223 nm. We observe separate rings in the slow channel of the velocity distribution of S( 1 D 2 ) correlating to single CO(J) rotational states. The additional available energy for photolysis at 223 nm is found to be channeled mostly into the CO(J) rotational motion. An improved value for the OC-S bond energy D 0 =4.292 eV is reported

  14. Low-fat dietary pattern and weight change over 7 years: the Women's Health Initiative Dietary Modification Trial.

    Science.gov (United States)

    Howard, Barbara V; Manson, JoAnn E; Stefanick, Marcia L; Beresford, Shirley A; Frank, Gail; Jones, Bobette; Rodabough, Rebecca J; Snetselaar, Linda; Thomson, Cynthia; Tinker, Lesley; Vitolins, Mara; Prentice, Ross

    2006-01-04

    Obesity in the United States has increased dramatically during the past several decades. There is debate about optimum calorie balance for prevention of weight gain, and proponents of some low-carbohydrate diet regimens have suggested that the increasing obesity may be attributed, in part, to low-fat, high-carbohydrate diets. To report data on body weight in a long-term, low-fat diet trial for which the primary end points were breast and colorectal cancer and to examine the relationships between weight changes and changes in dietary components. Randomized intervention trial of 48,835 postmenopausal women in the United States who were of diverse backgrounds and ethnicities and participated in the Women's Health Initiative Dietary Modification Trial; 40% (19,541) were randomized to the intervention and 60% (29,294) to a control group. Study enrollment was between 1993 and 1998, and this analysis includes a mean follow-up of 7.5 years (through August 31, 2004). The intervention included group and individual sessions to promote a decrease in fat intake and increases in vegetable, fruit, and grain consumption and did not include weight loss or caloric restriction goals. The control group received diet-related education materials. Change in body weight from baseline to follow-up. Women in the intervention group lost weight in the first year (mean of 2.2 kg, Pfruit servings, and a nonsignificant trend toward weight loss occurred with increasing intake of fiber. A low-fat eating pattern does not result in weight gain in postmenopausal women. Clinical Trial Registration ClinicalTrials.gov, NCT00000611.

  15. Free coffee and cake! A retention initiative to promote first year business school students’ social interaction with their peers and staff

    OpenAIRE

    Jackson, Victoria

    2014-01-01

    This paper discusses the findings from a small case study which involved implementing a social initiative with year 1 students on retention ‘hotspot’ programmes in the Business School. Financed by the internal TLA fund, this initiative involved running four coffee and cake events over an academic year specifically for students on the hotspot programmes. The purpose of these events was to facilitate student interaction with other students and lecturers in the department, to promote social enga...

  16. DESY: HERA polarization

    International Nuclear Information System (INIS)

    Anon.

    1992-01-01

    The new HERA electron-proton collider at DESY in Hamburg achieved the first luminosity for electron-proton collisions on 19 October last year. Only one month later, on 20 November, HERA passed another important milestone with the observation of transverse electron polarization

  17. Results from Polish Spondyloarthritis Initiative registry (PolSPI) - methodology and data from - the first year of observation.

    Science.gov (United States)

    Guła, Zofia; Barczyńska, Tacjana; Brzosko, Marek; Gąsowski, Jerzy; Jeka, Sławomir; Jodłowska-Cicio, Katarzyna; Kwaśny-Krochin, Beata; Leszczyński, Piotr; Lubiński, Łukasz; Łosińska, Katarzyna; Pawlak-Buś, Katarzyna; Przepiera-Będzak, Hanna; Samborski, Włodzimierz; Schlabs, Małgorzata; Siedlar, Maciej; Sikorska, Dorota; Świerkot, Jerzy; Węgierska, Małgorzata; Wiland, Piotr; Korkosz, Mariusz

    2017-01-01

    Report on one-year results from the Polish Spondyloarthritis Initiative registry (PolSPI), containing the cross-sectional analysis of clinical and imaging data as well as database methodology. The PolSPI registry includes patients with axial (axSpA) and peripheral (perSpA) spondyloarthritis according to ASAS classification criteria, and/or patients with ankylosing spondylitis according to modified New York criteria, psoriatic arthritis according to CASPAR criteria, arthropathy in inflammatory bowel disease, reactive arthritis, juvenile spondyloarthritis or undifferentiated spondyloarthritis. Epidemiologic data and history of signs, symptoms and treatment of spondyloarthritis are collected and assessment of disease activity is performed. Radiographic images of sacroiliac joint, cervical and lumbar spine, and results of bone densitometry are collected. Every 6 months blood samples for inflammatory markers, and for long-term storage are taken. During a one-year period from September 2015 to August 2016, 63 patients were registered on an electronic database; 44 (69.8%) of patients were classified as axial spondyloarthritis (axSpA) and 19 (30.2%) as peripheral spondyloarthritis (perSpA) according to ASAS criteria. Statistically significant differences between axSpA and perSpA were discovered in the percentage of HLA-B27 antigen occurrence (92.6% and 50%, respectively), BASDAI (2.8% and 4.1%, respectively), DAS 28 (2.66% and 4.03%, respectively), percentage of peripheral arthritis (20% and 88.8%, respectively), enthesitis (26.7% and 70.6%, respectively), dactylitis (6.7% and 88.9%, respectively), as well as extra-articular symptoms: acute anterior uveitis (26.7% and 5.6%, respectively) and psoriasis (6.9% and 55.6%, respectively). Patients with axSpA had significantly higher mean grade of sacroiliac involvement according to New York criteria, higher mSASSS score, and lower T-score in femoral neck in bone densitometry. At the early stage of the disease patients with ax

  18. Polarization Imaging and Insect Vision

    Science.gov (United States)

    Green, Adam S.; Ohmann, Paul R.; Leininger, Nick E.; Kavanaugh, James A.

    2010-01-01

    For several years we have included discussions about insect vision in the optics units of our introductory physics courses. This topic is a natural extension of demonstrations involving Brewster's reflection and Rayleigh scattering of polarized light because many insects heavily rely on optical polarization for navigation and communication.…

  19. Promoting Diversity Through Polar Interdisciplinary Coordinated Education (Polar ICE)

    Science.gov (United States)

    McDonnell, J. D.; Hotaling, L. A.; Garza, C.; Van Dyk, P. B.; Hunter-thomson, K. I.; Middendorf, J.; Daniel, A.; Matsumoto, G. I.; Schofield, O.

    2017-12-01

    Polar Interdisciplinary Coordinated Education (ICE) is an education and outreach program designed to provide public access to the Antarctic and Arctic regions through polar data and interactions with the scientists. The program provides multi-faceted science communication training for early career scientists that consist of a face-to face workshop and opportunities to apply these skills. The key components of the scientist training workshop include cultural competency training, deconstructing/decoding science for non-expert audiences, the art of telling science stories, and networking with members of the education and outreach community and reflecting on communication skills. Scientists partner with educators to provide professional development for K-12 educators and support for student research symposia. Polar ICE has initiated a Polar Literacy initiative that provides both a grounding in big ideas in polar science and science communication training designed to underscore the importance of the Polar Regions to the public while promoting interdisciplinary collaborations between scientists and educators. Our ultimate objective is to promote STEM identity through professional development of scientists and educators while developing career awareness of STEM pathways in Polar science.

  20. The polar mesosphere

    International Nuclear Information System (INIS)

    Morris, Ray; Murphy, Damian

    2008-01-01

    The mesosphere region, which lies at the edge of space, contains the coldest layer of the Earth's atmosphere, with summer temperatures as low as minus 130 °C. In this extreme environment ice aerosol layers have appeared since the dawn of industrialization—whose existence may arguably be linked to human influence—on yet another layer of the Earth's fragile atmosphere. Ground-based and space-based experiments conducted in the Arctic and Antarctic during the International Polar Year (IPY) aim to address limitations in our knowledge and to advance our understanding of thermal and dynamical processes at play in the polar mesosphere

  1. Polarization measurement in the COMPASS polarized target

    CERN Document Server

    Kondo, K; Baum, G; Berglund, P; Doshita, N; Gautheron, F; Görtz, S; Hasegawa, T; Horikawa, N; Ishimoto, S; Iwata, T; Kisselev, Yu V; Koivuniemi, J H; Le Goff, J M; Magnon, A; Meyer, W; Reicherz, G; Matsuda, T

    2004-01-01

    Continuous wave nuclear magnetic resonance (NMR) is used to determine the target polarization in the COMPASS experiment. The system is made of the so-called Liverpool Q-meters, Yale-cards, and VME modules for data taking and system controlling. In 2001 the NMR coils were embedded in the target material, while in 2002 and 2003 the coils were mounted on the outer surface of the target cells to increase the packing factor of the material. Though the error of the measurement became larger with the outer coils than with the inner coils, we have performed stable measurements throughout the COMPASS run time for 3 years. The maximum polarization was +57% and -53% as the average in the target cells.

  2. Physics of polarized targets

    CERN Document Server

    Niinikoski, Tapio

    2014-01-01

    For developing, building and operating solid polarized targets we need to understand several fields of physics that have seen sub stantial advances during the last 50 years. W e shall briefly review a selection of those that are important today. These are: 1) quantum statistical methods to describe saturation and relaxation in magnetic resonance; 2) equal spin temperature model for dy namic nuclear polarization; 3 ) weak saturation during NMR polarization measurement; 4 ) refrigeration using the quantum fluid properties of helium isotopes. These, combined with superconducting magnet technologies, permit today to reach nearly complete pola rization of almost any nuclear spins. Targets can be operated in frozen spin mode in rather low and inhomogeneous field of any orientation, and in DNP mode in beams of high intensity. Beyond such experiments of nuclear and particle physics, applications a re also emerging in macromolecular chemistry and in magnetic resonance imaging. This talk is a tribute to Michel Borghini...

  3. Polarized source upgrading

    International Nuclear Information System (INIS)

    Clegg, T.B.; Rummel, R.L.; Carter, E.P.; Westerfeldt, C.R.; Lovette, A.W.; Edwards, S.E.

    1985-01-01

    The decision was made this past year to move the Lamb-shift polarized ion source which was first installed in the laboratory in 1970. The motivation was the need to improve the flexibility of spin-axis orientation by installing the ion source with a new Wien-filter spin precessor which is capable of rotating physically about the beam axis. The move of the polarized source was accomplished in approximately two months, with the accelerator being turned off for experiments during approximately four weeks of this time. The occasion of the move provided the opportunity to rewire completely the entire polarized ion source frame and to rebuild approximately half of the electronic chassis on the source. The result is an ion source which is now logically wired and carefully documented. Beams obtained from the source are much more stable than those previously available

  4. A lunar polar expedition

    Science.gov (United States)

    Dowling, Richard; Staehle, Robert L.; Svitek, Tomas

    1992-09-01

    Advanced exploration and development in harsh environments require mastery of basic human survival skill. Expeditions into the lethal climates of Earth's polar regions offer useful lessons for tommorrow's lunar pioneers. In Arctic and Antarctic exploration, 'wintering over' was a crucial milestone. The ability to establish a supply base and survive months of polar cold and darkness made extensive travel and exploration possible. Because of the possibility of near-constant solar illumination, the lunar polar regions, unlike Earth's may offer the most hospitable site for habitation. The World Space Foundation is examining a scenario for establishing a five-person expeditionary team on the lunar north pole for one year. This paper is a status report on a point design addressing site selection, transportation, power, and life support requirements.

  5. Natural History of Intrameniscal Signal Intensity on Knee MR Images: Six Years of Data from the Osteoarthritis Initiative

    Science.gov (United States)

    Roemer, Frank W.; Guermazi, Ali; Turkiewicz, Aleksandra; Englund, Martin

    2016-01-01

    Purpose To assess the natural history of intrameniscal signal intensity on magnetic resonance (MR) images of the medial compartment. Materials and Methods Both knees of 269 participants (55% women, aged 45–55 years) in the Osteoarthritis Initiative without radiographic knee osteoarthritis (OA) and without medial meniscal tear at baseline were studied. One radiologist assessed 3-T MR images from baseline and 24-, 48-, and 72-month follow-up for intrameniscal signal intensity and tears. A complementary log-log model with random effect was used to evaluate the risk of medial meniscal tear, adjusting for age, sex, body mass index, and knee side. Results At baseline, linear intrameniscal signal intensity in the medial compartment was present in 140 knees (26%). Once present, regression only in a single knee was observed. In 31 knees (19%) with linear intrameniscal signal intensity at any of the first three time points, the signal intensity progressed to a tear in the same segment, and in a single knee, the tear occurred in an adjacent segment. The corresponding number of tears without prior finding of intrameniscal signal intensities was 11 (3%). In the adjusted model, the hazard ratio for developing medial meniscal tear was 18.2 (95% confidence interval: 8.3, 39.8) if linear intrameniscal signal intensity was present, compared when there was no linear signal intensity. There was only one of 43 knees with injury reported in conjunction with the incident tear. Conclusion In middle-aged persons without OA, linear intrameniscal signal intensity on MR images is highly unlikely to resolve and should be considered a risk factor for medial degenerative meniscal tear. © RSNA, 2015 Online supplemental material is available for this article. PMID:26172533

  6. Two-year clinical and radiologic follow-up of early RA patients treated with initial step up monotherapy or initial step down therapy with glucocorticoids, followed by a tight control approach: lessons from a cohort study in daily practice.

    Science.gov (United States)

    De Cock, D; Vanderschueren, G; Meyfroidt, S; Joly, J; Westhovens, R; Verschueren, P

    2014-01-01

    The objective of the study was to evaluate the effect of initial disease-modifying antirheumatic drug (DMARD) combination therapy with steroids (ICTS) and DMARD monotherapy (IMT) on the clinical and radiologic evolution of patients with early rheumatoid arthritis (RA) over a 2-year treatment period, applying tight control (TC) in daily practice. Seventy-four DMARD-naive early RA patients received ICTS or IMT in a TC setting. Baseline and year 1 and year 2 X-rays of hands and feet were scored according to Sharp/van der Heijde. Rapid radiographic progression (RRP) was defined as total Sharp score (TSS) of >5 units/year. At year 1, both treatment groups achieved 50 % remission. At year 2, 37 % of IMT and 60 % of ICTS patients were in remission, despite ICTS patients having initially a more severe RA profile. RRP was found in 4/74 patients at year 1: 3 IMT and 1 ICTS patients. Remarkably, three of these four patients had no radiographic progression in the second year. Five other patients had RRP in the second year: four IMT and one ICTS patients. In a TC setting, ICTS and IMT can prevent radiographic progression in the majority of patients in the daily practice of a Belgian academic hospital over 2 years. ICTS seems to be more effective than IMT in achieving higher remission rates and less radiographic progression.

  7. Caries-inhibiting effect of professional fluoride gel application in low-caries children initially aged 4.5-6.5 years.

    NARCIS (Netherlands)

    Rijkom, H.M. van; Truin, G.J.; Hof, M.A. van 't

    2004-01-01

    It was the purpose of the study to investigate the caries-reducing effect of semi-annual professional fluoride gel application in a low-caries child population initially aged 4.5-6.5 years during a 4-year follow-up period. In a double-blind randomised controlled trial (n = 773) the effect of sodium

  8. Investigating Sophomore Student Success: The National Survey of Sophomore-Year Initiatives and the Sophomore Experiences Survey, 2014. Research Reports on College Transitions No. 6

    Science.gov (United States)

    Young, Dallin George; Schreiner, Laurie A.; McIntosh, Eric J.

    2015-01-01

    Less is known about the second college year compared to other transition points, and fewer high-impact initiatives and curricular programs tend to be offered to sophomores. To increase our knowledge of this important, but sometimes neglected, year on the collegiate journey, "Investigating Sophomore Student Success" presents findings from…

  9. Aerosol Number Size Distribution and Type Classification from 4-Year Polarization Optical Particle Counter (POPC) Measurements at Urban-Mountain Site in Seoul

    Science.gov (United States)

    Park, H. J.; Kim, S. W.; Kobayashi, H.; Nishizawa, T.

    2017-12-01

    The Polarization Optical Particle Counter (POPC), unlike general OPCs, has the advantage capable of classifying the aerosol types (e.g., dust, anthropogenic pollution), because it measures particle number, size and depolarization ratio (DPR; the sphericity information of single particle) for 4 size bins with diameter (0.5-1, 1-3, 3-5, 5-10 μm). In this study, we investigate the temporal variations of particle number and volume size distributions with DPR values and classify aerosol types such as dust, anthropogenic pollution, from 4-year (2013-2016) POPC data at Seoul National University campus in Seoul, Korea. Coarse mode particles from 5-10 μm with relatively high DPR values (0.25-0.3) were distinctly appeared in in both spring (March-May) and winter (December-February) due to frequent transport of Asian dust particles. In summer (June -August), however, both aerosol number concentration and DPR value were decreased in all size bins due to the influences of relatively clean maritime airmass and frequent precipitations. In autumn (September - November), the particle number concentration in all size bins was the lowest. To classify the aerosol types, we investigate particle number and volume size distributions and DPR value for clean, dust-dominant and anthropogenic pollution-dominant cases, which were selected by PM10, PM2.5 mass concentrations and its ratio, because those parameters are clearly different among aerosol types (Kobayashi et al., 2014, Pan et al., 2016). Non-spherical coarse mode particles (Dp > 2.5 μm, 0.1 < DPR < 0.6) were dominantly observed during the dust-dominant period, while both spherical fine mode and coarse mode particles (Dp < 1 μm and Dp = 2-4 μm, DPR < 0.1) were dominantly appeared during the pollution event. The aerosol type classifications with these criteria values were successfully applied to the extreme Asian dust event from February 22 to 24, 2015. The results showed that pollution-dominant airmass preceded by the appearance

  10. Getting around Antarctica: new high-resolution mappings of the grounded and freely-floating boundaries of the Antarctic ice sheet created for the International Polar Year

    Directory of Open Access Journals (Sweden)

    R. Bindschadler

    2011-07-01

    Full Text Available Two ice-dynamic transitions of the Antarctic ice sheet – the boundary of grounded ice features and the freely-floating boundary – are mapped at 15-m resolution by participants of the International Polar Year project ASAID using customized software combining Landsat-7 imagery and ICESat/GLAS laser altimetry. The grounded ice boundary is 53 610 km long; 74 % abuts to floating ice shelves or outlet glaciers, 19 % is adjacent to open or sea-ice covered ocean, and 7 % of the boundary ice terminates on land. The freely-floating boundary, called here the hydrostatic line, is the most landward position on ice shelves that expresses the full amplitude of oscillating ocean tides. It extends 27 521 km and is discontinuous. Positional (one-sigma accuracies of the grounded ice boundary vary an order of magnitude ranging from ±52 m for the land and open-ocean terminating segments to ±502 m for the outlet glaciers. The hydrostatic line is less well positioned with errors over 2 km. Elevations along each line are selected from 6 candidate digital elevation models based on their agreement with ICESat elevation values and surface shape inferred from the Landsat imagery. Elevations along the hydrostatic line are converted to ice thicknesses by applying a firn-correction factor and a flotation criterion. BEDMAP-compiled data and other airborne data are compared to the ASAID elevations and ice thicknesses to arrive at quantitative (one-sigma uncertainties of surface elevations of ±3.6, ±9.6, ±11.4, ±30 and ±100 m for five ASAID-assigned confidence levels. Over one-half of the surface elevations along the grounded ice boundary and over one-third of the hydrostatic line elevations are ranked in the highest two confidence categories. A comparison between ASAID-calculated ice shelf thicknesses and BEDMAP-compiled data indicate a thin-ice bias of 41.2 ± 71.3 m for the ASAID ice thicknesses. The relationship between the seaward offset of the hydrostatic line

  11. Dynamic elections and ideological polarization

    Czech Academy of Sciences Publication Activity Database

    Nunnari, S.; Zápal, Jan

    2017-01-01

    Roč. 25, č. 4 (2017), s. 505-534 ISSN 1047-1987 Institutional support: Progres-Q24 Keywords : elections * political polarization Subject RIV: AH - Economics OBOR OECD: Economic Theory Impact factor: 3.361, year: 2016

  12. Dynamic elections and ideological polarization

    Czech Academy of Sciences Publication Activity Database

    Nunnari, S.; Zápal, Jan

    2017-01-01

    Roč. 25, č. 4 (2017), s. 505-534 ISSN 1047-1987 Institutional support: RVO:67985998 Keywords : elections * political polarization Subject RIV: AH - Economics OBOR OECD: Economic Theory Impact factor: 3.361, year: 2016

  13. Coast Guard Polar Icebreaker Modernization: Background, Issues, and Options for Congress

    National Research Council Canada - National Science Library

    O'Rourke, Ronald

    2008-01-01

    Of the Coast Guard's three polar icebreakers, two Polar Star and Polar Sea have exceeded their intended 30-year service lives, and Polar Star is not operational and has been caretaker status since July 1, 2006...

  14. Earnings management behavior of the initial public offering (IPO) firms during pre-IPO, IPO, and post-IPO years

    DEFF Research Database (Denmark)

    Farooq, Omar; Benali, Meryem

    2012-01-01

    . We argue that the need for making reputation as a profitable firm induces management to managing earnings during the pre-IPO years. This need to manage earnings is the most during the year of an IPO because announcing earnings that are lesser than the previous years would hurt the reputation......This paper examines the pattern of earnings management around the IPO year in Morocco during the period between 2001 and 2007. Our results show that earnings management reaches its maximum level during the year of an IPO followed earnings management during the pre-IPO years and the post-IPO years...... of a firm in the eyes of potential investors/shareholder and would reduce the offering proceeds. However, as firm enters the post-IPO years, lower requirements of raising capital in immediate future along with greater scrutiny from stock market participant’s result in lower incentives to manage earnings....

  15. Long-Term Immunogenicity of Hepatitis A Virus Vaccine in Alaska 17 Years After Initial Childhood Series

    Science.gov (United States)

    Raczniak, Gregory A.; Bulkow, Lisa R.; Bruce, Michael G.; Zanis, Carolyn L.; Baum, Richard L.; Snowball, Mary M.; Byrd, Kathy K.; Sharapov, Umid M.; Hennessy, Thomas W.; McMahon, Brian J.

    2013-01-01

    The Centers for Disease Control and Prevention recommends hepatitis A virus (HAV) vaccination for all children at age 1 year and for high-risk adults. The vaccine is highly effective; however, protection duration is unknown. We report HAV antibody concentrations 17 years after childhood immunization, demonstrating that protective antibody levels remain and have stabilized over the past 7 years. PMID:23204169

  16. RHIC Polarized proton performance in run-8

    International Nuclear Information System (INIS)

    Montag, C.; Bai, M.; MacKay, W.W.; Roser, T.; Abreu, N.; Ahrens, L.; Barton, D.; Beebe-Wang, J.; Blaskiewicz, M.; Brennan, J.M.; Brown, K.A.; Bruno, D.; Bunce, G.; Calaga, R.; Cameron, P.; Connolly, R.; D'Ottavio, T.; Drees, A.; Fedotov, A.V.; Fischer, W.; Ganetis, G.; Gardner, C.; Glenn, J.; Hayes, T.; Huang, H.; Ingrassia, P.; Kayran, D.A.; Kewisch, J.; Lee, R.C.; Lin, F.; Litvinenko, V.N.; Luccio, A.U.; Luo, Y.; Makdisi, Y.; Malitsky, N.; Marr, G.; Marusic, A.; Michnoff, R.; Morris, J.; Oerter, B.; Pilat, F.; Pile, P.; Robert-Demolaize, G.; Russo, T.; Satogata, T.; Schultheiss, C.; Sivertz, M.; Smith, K.; Tepikian, S.; Trbojevic, D.; Tsoupas, N.; Tuozzolo, J.; Zaltsman, A.; Zelenski, A.; Zeno, K.; Zhang, S.Y.

    2008-01-01

    During Run-8, the Relativistic Heavy Ion Collider (RHIC) provided collisions of spin-polarized proton beams at two interaction regions. Physics data were taken with vertical orientation of the beam polarization, which in the 'Yellow' RHIC ring was significantly lower than in previous years. We present recent developments and improvements as well as the luminosity and polarization performance achieved during Run-8, and we discuss possible causes of the not as high as previously achieved polarization performance of the 'Yellow' ring.

  17. 77 FR 70410 - Endangered and Threatened Wildlife and Plants; Initiation of Status Review and 5-Year Review of...

    Science.gov (United States)

    2012-11-26

    ...-0095; FXES11130900000-134-FF09E30000] Endangered and Threatened Wildlife and Plants; Initiation of... Linner, Field Supervisor, Colorado Ecological Services Office; mailing address P.O. Box 25486, DFC (MS... SPR (76 FR 76987); and (8) Information regarding contact and interaction among Preble's populations or...

  18. Comparing Student, Instructor, Classroom and Institutional Data to Evaluate a Seven-Year Department-Wide Science Education Initiative

    Science.gov (United States)

    Jones, Francis

    2018-01-01

    We compared seven unrelated data-sets to evaluate a major education improvement initiative. Perceptions of students in 54 course sections were surveyed regarding the helpfulness of 39 specific teaching or learning strategies, and relative workloads and enthusiasm were compared to their other courses. Classes were observed using an established…

  19. Hyperon polarization: An experimental overview

    International Nuclear Information System (INIS)

    Lach, J.

    1992-12-01

    The fact that inclusively produced hyperons are produced with significant polarization was first discovered at Fermilab about seventeen years ago. This and subsequent experiments showed that Λ degree were produced polarized while bar Λ degree had no polarization in the same kinematical region. This set the stage for many experiments which showed that most hyperons are produced polarized. Recent Fermilab experiments have showed that this phenomena is even more complex than previously thought and theoretical understanding is still lacking. Nevertheless polarized hyperon beams have been an extremely useful experimental tool in measuring hyperon magnetic moments and hyperon β-decay. Recently, hyperon radiative decays have been studied and magnetic moment precession of channeled particles in bent crystals has been observed

  20. A chronicle of just-in-time information: The secret to building first year university student wellbeing and resilience based on a three year initiative

    Directory of Open Access Journals (Sweden)

    Donnalee Taylor

    2016-10-01

    Full Text Available To date, little has been published on the provision of student-driven just-in-time information to support first year students. This chronicle of just-in-time curricular and extra-curricular student support information was designed early in 2014 and successfully disseminated to first year biomedical science students over three years at James Cook University, Townsville, Queensland, Australia. In 2016, the information was redeveloped to make the support information electronically available to a much broader student audience. This article provides a dissemination template of what just-in-time curricular and extra-curricular information is required by first year university students. In addition, it outlines how students’ need for this information was determined and how information was successfully created and disseminated over these three years to assist the students in their transition to and through university. The intention of this article is to contribute to the growing body of knowledge on student resilience and wellbeing and to provide a guide for anyone interested in supporting their students in a similar manner.

  1. A chronicle of just-in-time information: The secret to building first year university student wellbeing and resilience based on a three year initiative.

    Directory of Open Access Journals (Sweden)

    Donnalee Taylor

    2017-03-01

    Full Text Available To date, little has been published on the provision of student-driven just-in-time information to support first year students. This chronicle of just-in-time curricular and extra-curricular student support information was designed early in 2014 and successfully disseminated to first year biomedical science students over three years at James Cook University, Townsville, Queensland, Australia. In 2016, the information was redeveloped to make the support information electronically available to a much broader student audience. This article provides a dissemination template of what just-in-time curricular and extra-curricular information is required by first year university students. In addition, it outlines how students’ need for this information was determined and how information was successfully created and disseminated over these three years to assist the students in their transition to and through university. The intention of this article is to contribute to the growing body of knowledge on student resilience and wellbeing and to provide a guide for anyone interested in supporting their students in a similar manner.

  2. Back to the Future: First-Year Writing in the Binghamton University Writing Initiative, State University of New York

    Science.gov (United States)

    Kinney, Kelly; Costello, Kristi Murray

    2010-01-01

    This essay seeks to explain the history that led to the establishment of First-Year Writing at Binghamton University, a program which offers a set of electives that complement discipline-specific and writing-across-the-curriculum courses while providing first-year students a common experience in and comprehensive introduction to college writing.

  3. Initial thinning effects in 70- to 150-year-old Douglas-fir--western Oregon and Washington.

    Science.gov (United States)

    Richard L. Williamson; Frank E. Price

    1971-01-01

    Vigorous, mature (post-rotation age) Douglas-fir stands will probably exist for another 50 years or more on some properties in western Oregon and Washington. Intermediate harvests in the form of thinnings were analyzed on nine study areas ranging from 70 to 150 years old when thinned. Recoverable cubic-volume growth, averaging 81 percent of normal...

  4. Boys with Asperger Syndrome Grow Up: Psychiatric and Neurodevelopmental Disorders 20 Years after Initial Diagnosis

    Science.gov (United States)

    Gillberg, I. Carina; Helles, Adam; Billstedt, Eva; Gillberg, Christopher

    2016-01-01

    We examined comorbid psychiatric and neurodevelopmental disorders in fifty adult males (mean age 30 years) with Asperger syndrome (AS) diagnosed in childhood and followed up prospectively for almost two decades (13-26 years). Only three of the 50 men had "never" met criteria for an additional psychiatric/neurodevelopmental diagnosis and…

  5. ProVac Global Initiative: a vision shaped by ten years of supporting evidence-based policy decisions.

    Science.gov (United States)

    Jauregui, Barbara; Janusz, Cara Bess; Clark, Andrew D; Sinha, Anushua; Garcia, Ana Gabriela Felix; Resch, Stephen; Toscano, Cristiana M; Sanderson, Colin; Andrus, Jon Kim

    2015-05-07

    The Pan American Health Organization (PAHO) created the ProVac Initiative in 2004 with the goal of strengthening national technical capacity to make evidence-based decisions on new vaccine introduction, focusing on economic evaluations. In view of the 10th anniversary of the ProVac Initiative, this article describes its progress and reflects on lessons learned to guide the next phase. We quantified the output of the Initiative's capacity-building efforts and critically assess its progress toward achieving the milestones originally proposed in 2004. Additionally, we reviewed how country studies supported by ProVac have directly informed and strengthened the deliberations around new vaccine introduction. Since 2004, ProVac has conducted four regional workshops and supported 24 health economic analyses in 15 Latin American and Caribbean countries. Five Regional Centers of Excellence were funded, resulting in six operational research projects and nine publications. Twenty four decisions on new vaccine introductions were supported with ProVac studies. Enduring products include the TRIVAC and CERVIVAC cost-effectiveness models, the COSTVAC program costing model, methodological guides, workshop training materials and the OLIVES on-line data repository. Ten NITAGs were strengthened through ProVac activities. The evidence accumulated suggests that initiatives with emphasis on sustainable training and direct support for countries to generate evidence themselves, can help accelerate the introduction of the most valuable new vaccines. International and Regional Networks of Collaborators are necessary to provide technical support and tools to national teams conducting analyses. Timeliness, integration, quality and country ownership of the process are four necessary guiding principles for national economic evaluations to have an impact on policymaking. It would be an asset to have a model that offers different levels of complexity to choose from depending on the vaccine being

  6. A Reappraisal of Women’s Health Initiative Estrogen-Alone Trial: Long-Term Outcomes in Women 50–59 Years of Age

    Directory of Open Access Journals (Sweden)

    Eric Roehm

    2015-01-01

    Full Text Available The Women’s Health Initiative (WHI Estrogen-Alone Trial randomized postmenopausal women, 50 to 79 years of age, with prior hysterectomy, to conjugated equine estrogens (CEE or placebo with a 5.9-year median duration of CEE use. In 2013, the WHI published outcomes for additional extended follow-up. Reported here for the first time is an analysis of the number needed to treat with CEE rather than placebo for younger women (50–59 years to prevent an adverse long-term outcome. For every 76 women randomized to CEE at 50–59 years, one less myocardial infarction occurred during the 13-year cumulative long-term follow-up. For every 37 women randomized to CEE at 50–59 years, one less woman experienced a global index endpoint (including coronary heart disease, invasive breast cancer, stroke, pulmonary embolism, colorectal cancer, hip fracture, and death during the 13-year follow-up. Younger women (50–59 years, compared to older women, had more favorable cumulative long-term outcomes for MI and global index. Though a subgroup analysis is not an adequate basis for making primary prevention guideline recommendations, the WHI Estrogen-Alone Trial outcomes strongly suggest that a similar course of estrogen initiated at 50–59 years in postmenopausal women with prior hysterectomy results in significant long-term health benefit.

  7. Acute Kidney Injury in Burn Patients: Clinically Significant Over the Initial Hospitalization and 1 Year After Injury: An Original Retrospective Cohort Study.

    Science.gov (United States)

    Thalji, Samih Z; Kothari, Anai N; Kuo, Paul C; Mosier, Michael J

    2017-08-01

    To examine the development of acute kidney injury (AKI) after burn injury as an independent risk factor for increased morbidity and mortality over initial hospitalization and 1-year follow-up. Variability in fluid resuscitation and difficulty recognizing early sepsis are major barriers to preventing AKI after burn injury. Expanding our understanding of the burden AKI has on the clinical course of burn patients would highlight the need for standardized protocols. We queried the Healthcare Cost and Utilization Project State Inpatient Databases in the states of Florida and New York during the years 2009 to 2013 for patients over age 18 hospitalized with a primary diagnosis of burn injury using ICD-9 codes. We identified and grouped 18,155 patients, including 1476 with burns >20% total body surface area, by presence of AKI. Outcomes were compared in these cohorts via univariate analysis and multivariate logistic regression models. During initial hospitalization, AKI was associated with increased pulmonary failure, mechanical ventilation, pneumonia, myocardial infarction, length of stay, cost, and mortality, and also a lower likelihood of being discharged home. One year after injury, AKI was associated with development of chronic kidney disease, conversion to chronic dialysis, hospital readmission, and long-term mortality. AKI is associated with a profound and severe increase in morbidity and mortality in burn patients during initial hospitalization and up to 1 year after injury. Consensus protocols for initial burn resuscitation and early sepsis recognition and treatment are crucial to avoid the consequences of AKI after burn injury.

  8. WHO European Childhood Obesity Surveillance Initiative: body mass index and level of overweight among 6-9-year-old children from school year 2007/2008 to school year 2009/2010.

    Science.gov (United States)

    Wijnhoven, Trudy M A; van Raaij, Joop M A; Spinelli, Angela; Starc, Gregor; Hassapidou, Maria; Spiroski, Igor; Rutter, Harry; Martos, Éva; Rito, Ana I; Hovengen, Ragnhild; Pérez-Farinós, Napoleón; Petrauskiene, Ausra; Eldin, Nazih; Braeckevelt, Lien; Pudule, Iveta; Kunešová, Marie; Breda, João

    2014-08-07

    The World Health Organization (WHO) Regional Office for Europe has established the Childhood Obesity Surveillance Initiative (COSI) to monitor changes in overweight in primary-school children. The aims of this paper are to present the anthropometric results of COSI Round 2 (2009/2010) and to explore changes in body mass index (BMI) and overweight among children within and across nine countries from school years 2007/2008 to 2009/2010. Using cross-sectional nationally representative samples of 6-9-year-olds, BMI, anthropometric Z-scores and overweight prevalence were derived from measured weight and height. Significant changes between rounds were assessed using variance and t-tests analyses. At Round 2, the prevalence of overweight (including obesity; WHO definitions) ranged from 18% to 57% among boys and from 18% to 50% among girls; 6 - 31% of boys and 5 - 21% of girls were obese. Southern European countries had the highest overweight prevalence. Between rounds, the absolute change in mean BMI (range: from -0.4 to +0.3) and BMI-for-age Z-scores (range: from -0.21 to +0.14) varied statistically significantly across countries. The highest significant decrease in BMI-for-age Z-scores was found in countries with higher absolute BMI values and the highest significant increase in countries with lower BMI values. The highest significant decrease in overweight prevalence was observed in Italy, Portugal and Slovenia and the highest significant increase in Latvia and Norway. Changes in BMI and prevalence of overweight over a two-year period varied significantly among European countries. It may be that countries with higher prevalence of overweight in COSI Round 1 have implemented interventions to try to remedy this situation.

  9. Precessing deuteron polarization

    International Nuclear Information System (INIS)

    Sitnik, I.M.; Volkov, V.I.; Kirillov, D.A.; Piskunov, N.M.; Plis, Yu.A.

    2002-01-01

    The feasibility of the acceleration in the Nuclotron of deuterons polarized in the horizontal plane is considered. This horizontal polarization is named precessing polarization. The effects of the main magnetic field and synchrotron oscillations are included. The precessing polarization is supposed to be used in studying the polarization parameters of the elastic dp back-scattering and other experiments

  10. Prognosis of HIV-1-infected patients up to 5 years after initiation of HAART: collaborative analysis of prospective studies

    DEFF Research Database (Denmark)

    May, M; Sterne, JAC; Sabin, C

    2007-01-01

    : On the basis of data collected routinely in HIV care, prognostic models with high discriminatory power over 5 years were developed for patients starting HAART in industrialized countries. A risk calculator that produces estimates for progression rates at years 1 to 5 after starting HAART is available from www.art-cohort-collaboration.org.......-to-continue-treatment, ignoring treatment changes and interruptions. RESULTS: During 61 798 person-years of follow-up, 1005 patients died and an additional 1303 developed AIDS. A total of 10 046 (49%) patients started HAART either with a CD4 cell count of less than 200 cells/microl or with a diagnosis of AIDS. The 5-year risk...

  11. Similar efficacy and safety of initial COBRA-light and COBRA therapy in rheumatoid arthritis: 4-year results from the COBRA-light trial.

    Science.gov (United States)

    Konijn, Nicole P C; van Tuyl, Lilian H D; Boers, Maarten; den Uyl, Debby; Ter Wee, Marieke M; van der Wijden, Lindsey K M; Bultink, Irene E M; Kerstens, Pit J S M; Voskuyl, Alexandre E; van Schaardenburg, Dirkjan; Nurmohamed, Michael T; Lems, Willem F

    2017-09-01

    To assess the efficacy and safety of initial COBRA-light vs COBRA therapy in RA patients after a 4-year follow-up period. In the COBRA-light trial, 162 consecutive patients with recent-onset RA were randomized to either COBRA-light (prednisolone and MTX) or COBRA therapy (prednisolone, MTX and SSZ) for 1 year. After 1 year, treatment was continued without protocol, and adjusted by the treating physician according to clinical judgement, preferably with a treat-to-target strategy. Four years after trial initiation, all patients were invited to participate in the COBRA-light extension study, in which patients were interviewed and physically examined, patient reported outcomes were assessed, radiographs were made and clinical records were examined for comorbidities and medication use. In the extension study, 149 out of 162 (92%) original trial patients participated: 72 COBRA-light and 77 COBRA patients. Initial COBRA-light and COBRA therapy showed similar effect on disease activity, physical functioning, radiological outcome and Boolean remission over the 4-year follow-up period. In addition, both treatment groups showed similar survival and major comorbidities, although the power to detect differences was limited. Besides protocolled differences in prednisolone, MTX and SSZ use, the use of other synthetic and biologic DMARDs and intra-articular and intramuscular glucocorticoid injections was similar in both treatment groups over the 4-year period. Early RA patients initially treated with COBRA-light or COBRA therapy had similar efficacy and safety outcomes over a 4-year follow-up period. © The Author 2017. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oup.com

  12. Strategies to Build Readiness in Community Mobilization Efforts for Implementation in a Multi-Year Teen Pregnancy Prevention Initiative.

    Science.gov (United States)

    Bhuiya, Nazmim; House, L Duane; Desmarais, Jeffrey; Fletcher, Erica; Conlin, Maeve; Perez-McAdoo, Sarah; Waggett, Jessica; Tendulkar, Shalini A

    2017-03-01

    This paper describes an assessment of community readiness to implement a community-wide teen pregnancy prevention initiative, Youth First, and presents strategies used to enhance this readiness as informed by the assessment. Twenty-five community stakeholder interviews were conducted to assess four domains of readiness: (1) attitudes, perception, and knowledge of teen pregnancy; (2) perceived level of readiness; (3) resources, existing and current efforts; and (4) leadership. Interview transcripts were coded and analyzed to identify key themes. Stakeholders acknowledged teen pregnancy as an issue but lacked contextual information. They also perceived the community as ready to address the issue and recognized some organizations already championing efforts. However, many key players were not involved, and ongoing data collection to assess teen pregnancy and prevention efforts was limited. Though many stakeholders were ready to engage in teen pregnancy prevention efforts, they required additional information and training to appropriately address the issue. In response to the assessment findings, several strategies were applied to address readiness and build Youth First partners' capacity to implement the community-wide initiative. Thus, to successfully implement community-wide prevention efforts, it is valuable to assess the level of community readiness to address health issues. Copyright © 2016 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.

  13. A systematic review of faculty development initiatives designed to enhance teaching effectiveness: A 10-year update: BEME Guide No. 40.

    Science.gov (United States)

    Steinert, Yvonne; Mann, Karen; Anderson, Brownell; Barnett, Bonnie Maureen; Centeno, Angel; Naismith, Laura; Prideaux, David; Spencer, John; Tullo, Ellen; Viggiano, Thomas; Ward, Helena; Dolmans, Diana

    2016-08-01

    This review, which focused on faculty development initiatives designed to improve teaching effectiveness, synthesized findings related to intervention types, study characteristics, individual and organizational outcomes, key features, and community building. This review included 111 studies (between 2002 and 2012) that met the review criteria. Overall satisfaction with faculty development programs was high. Participants reported increased confidence, enthusiasm, and awareness of effective educational practices. Gains in knowledge and skills, and self-reported changes in teaching behaviors, were frequently noted. Observed behavior changes included enhanced teaching practices, new educational initiatives, new leadership positions, and increased academic output. Organizational changes were infrequently explored. Key features included evidence-informed educational design, relevant content, experiential learning, feedback and reflection, educational projects, intentional community building, longitudinal program design, and institutional support. This review holds implications for practice and research. Moving forward, we should build on current success, broaden the focus beyond individual teaching effectiveness, develop programs that extend over time, promote workplace learning, foster community development, and secure institutional support. We should also embed studies in a theoretical framework, conduct more qualitative and mixed methods studies, assess behavioral and organizational change, evaluate transfer to practice, analyse key features, and explore the role of faculty development within the larger organizational context.

  14. Prospective longitudinal cohort study on cumulative 5-year delivery and adoption rates among 1338 couples initiating infertility treatment

    DEFF Research Database (Denmark)

    Pinborg, A; Hougaard, C O; Andersen, A Nyboe

    2009-01-01

    occurred for 5.9% (48/817) of the women. Positive prognostic factors for delivery were male infertility, female age infertility and less than three previous treatment cycles. CONCLUSIONS A crude delivery rate of 69.4% in the total population 5 years after referral to tertiary......BACKGROUND The objective was to assess crude 5-year delivery rates after assisted reproductive technology (ART) treatment, intrauterine inseminations (IUI), spontaneous conceptions (SC) and adoptions in a large infertile cohort. METHODS A prospective longitudinal survey comprised 1338 infertile...... couples starting public infertility programmes offering IUIs and three free ART cycles during 2000-2001. The cohort was cross-linked with the National Medical Birth Register to obtain delivery rates for all 1338 couples. More detailed data were available from 817 women responding to a 5-year follow...

  15. [Second Pneumothorax in an Ehlers-Danlos Syndrome Patient Initially Treated by Bullaectomy Twenty-two Years Ago].

    Science.gov (United States)

    Suzuki, Yamato; Ueda, Shinsaku; Suzuki, Satoshi

    2017-07-01

    A 2nd pneumothorax developed in a 40-years-old man after his 1st bilateral pneumothoraces were successfully treated by bullaectomies 22 years ago. For the past 10 years, he has suffered major complications such as repeated bleeding into the digestive tract due to vascular-type Ehlers-Danlos syndrome (vEDS). Although preoperative computed tomography demonstrated multiple bullae at the apex of the right lung, any abnormal findings suggesting tissue fragility was not found. At surgery, visceral pleura of the right lung had an almost normal appearance through a thoracoscope. However, we found that gentle touch with soft surgical equipment resulted in serious pleural damage leading to new air leakage. Our case suggests a progressive fragility of the lung in a vEDS patient, and a less invasive pleural covering technique would therefore be preferable when major complications become evident, despite previous successful bullaectomy.

  16. Acute Corneal Hydrops Mimicking Infectious Keratitis as Initial Presentation of Keratoconus in a 10-Year-Old Child

    Directory of Open Access Journals (Sweden)

    Elise A. Slim

    2015-01-01

    Full Text Available Purpose. To report a case of acute hydrops in a 10-year-old child with advanced keratoconus. Case Presentation. A ten-year-old boy diagnosed as having right eye (RE infectious keratitis, not responding to antimicrobial therapy, was referred to our hospital. The diagnosis of infectious keratitis was established one month prior to his presentation following an episode of acute corneal whitening, pain, and drop in visual acuity. Topical fortified antibiotics followed by topical antiviral therapy were used with no improvement. Slit lamp examination showed significant corneal protrusion with edema surrounding a rupture in Descemet’s membrane in the RE. The diagnosis of acute corneal hydrops from advanced keratoconus was highly suspected and confirmed with corneal topography. Conclusion. Although a relatively rare disease at the age of 10 years, keratoconus can be rapidly progressive in the pediatric group. Keratoconus should always be considered in the differential diagnosis of progressive vision loss in this age group.

  17. Symmetry breaking signaling mechanisms during cell polarization

    NARCIS (Netherlands)

    Bruurs, LJM

    2017-01-01

    Breaking of cellular symmetry in order to establish an apico-basal polarity axis initiates de novo formation of cell polarity. However, symmetry breaking provides a formidable challenge from a signaling perspective, because by definition no spatial cues are present to instruct axis establishment.

  18. Longitudinal changes in white matter disease and cognition in the first year of the Alzheimer disease neuroimaging initiative

    NARCIS (Netherlands)

    Carmichael, Owen; Schwarz, Christopher; Drucker, David; Fletcher, Evan; Harvey, Danielle; Beckett, Laurel; Jack, Clifford R.; Weiner, Michael; Decarli, Charles; Abdi, Herve; Abeliovich, Asa; Abellan van Kan, Gabor; Abner, Erin; Acharya, Deepa; Adams, Nicholas; Adler, Daniel; Agrusti, Antonella; Agyemang, Alex; Ahdidan, Jamila; Ahn, Jae Eun; Aisen, Paul; Aksu, Yaman; Al-Akhras, Mousa; Alarcon, Marcelo; Alberca, Roman; Alexander, Gene; Alexander, Daniel; Almeida, Fabio; Anand, Rishi; Anand, Shyam; Andrew, Marilee; Anjum, Ayesha; Aoyama, Eiji; Ard, Michael Colin; Arfanakis, Konstantinos; Armor, Tom; Arnold, Steven; Asatryan, Albert; Ashe-McNalley, Cody; Ashiga, Hirokazu; Assareh, Arezoo; Aubry, Florent; Avants, Brian; Avinash, Gopal; Awasthi, Sukrati; Ayan-Oshodi, Mosun; Bagci, Ulas; Bai, Shuyang; Baker, John; Banks, Sarah; Bard, Jonathan; Barnes, Josephine; Barret, Olivier; Bartzokis, George; Barua, Neil; Bauer, Corinna; Becker, James; Bednar, Martin; Beg, Mirza Faisal; Bek, Stephan; Bernard, Charlotte; Bertram, Lars; Bhagwagar, Zubin; Biffi, Alessandro; Bilgic, Basar; Bishnoi, Mahesh; Bishop, Courtney; Bittner, Daniel; Black, Ronald; Blennow, Kaj; Bogorodzki, Piotr; Bokde, Arun; Bonner-Jackson, Aaron; Boppana, Madhu; Bourgeat, Pierrick; Bowes, Mike; Bowman, Gene; Bowman, DuBois; Braskie, Meredith; Brewer, James; Brickman, Adam; Broadbent, Steve; Brooks, David; Browndyke, Jeffrey; Bruat, Vanessa; Brunton, Simon; Buchert, Ralph; Buchsbaum, Monte; Buckley, Chris; Burger, Cyrill; Burns, Jeffrey; Burton, David; Butman, John; Cabeza, Rafael; Cairns, Nigel; Callhoff, Johanna; Calvini, Piero; Campbell, Aaron; Cantillon, Marc; Capella, Heraldo; Cardona-Sanclemente, Luis Eduardo; Carle, Adam; Carmasin, Jeremy; Carranza-Ath, Fredy; Casanova, Ramon; Cash, David; Cella, Massimo; Celsis, Pierre; Chan, Lung Tat Andrew; Chaney, Megan; Chanu, Pascal; Chao, Linda; Charil, Arnaud; Chemali, Zeina; Chen, Baojiang; Chen, Kewei; Chen, Ting; Chen, Minhua; Chen, Gennan; Chen, Rong; Cheng, Wei-Chen; Chertkow, Howard; Chiang, Gloria; Chiba, Koji; Chisholm, Jane; Cho, Youngsang; Choe, John; Choubey, Suresh; Christensen, Anette Luther; Clark, Chris; Clark, David; Clarkson, Matt; Clayton, David; Clunie, David; Coimbra, Alexandre; Compton, David; Crane, Paul; Crans, Gerald; Croop, Robert; Crowther, Daniel; Crum, William; Cui, Yue; Curry, Charles; Curtis, Steven; Cutter, Gary; Daiello, Lori; Dake, Michael; Dale, Anders; Damato, Vito Domenico; Darby, Eveleen; Darkner, Sune; Davatzikos, Christos; Dave, Jay; David, Renaud; Davidson, Julie; de Bruijne, Marleen; de Meyer, Geert; de Nunzio, Giorgio; de Santi, Susan; Dechairo, Bryan; DeDuck, Kristina; Dejkam, Arsalan; Delfino, Manuel; Delpassand, Ebrahim; Deniz, Oscar; Denney, Douglas; DeOrchis, Vincent; Depy Carron, Delphine; deToledo-Morrell, Leyla; Devanand, Davangere; Devanarayan, Viswanath; Diaz, Gloria; Diaz-Arrastia, Ramon; Dickerson, Bradford; Dinov, Ivo; Dodge, Hiroko; Donohue, Michael; Dowling, Maritza; Drzezga, Alex; Duan, Xujun; Duchesne, Simon; Duff, Kevin; Dukart, Jurgen; Durazzo, Timothy; Dykstra, Kevin; Earl, Nancy; Edula, Goutham; Ekin, Ahmet; Engelman, Corinne; Epstein, Noam; Erten-Lyons, Deniz; Eskildsen, Simon; Falcone, Guido; Fan, Yong; Farnum, Michael; Farrer, Lindsay; Farzan, Ali; Feldman, Howard; Feng, Yan; Fennema-Notestine, Christine; Fernandes, Michel; Fernandez, Elsa; Ferrarini, Luca; Ferreira, Luiz; Ferrer, Eugene; Figurski, Michal; Filipovych, Roman; Finch, Stephen; Finlay, Daniel; Fiot, Jean-Baptiste; Flenniken, Derek; Fletcher, P. Thomas; Flynn Longmire, Crystal; Forman, Mark; Forsythe, Alan; Fox-Bosetti, Sabrina; Francis, Alexander L.; Franco-Villalobos, Conrado; Franko, Edit; Freeman, Stefanie; Friedrich, Christoph M.; Friesenhahn, Michel; Frings, Lars; Frisoni, Giovanni; Fritzsche, Klaus; Fujimoto, Yoko; Fujiwara, Ken; Fullerton, Terence; Furney, Simon; Gallins, Paul; Gamst, Anthony; Gan, Ke; Garcia, Maria Teresa; Garcia-Linares, Antonio; Garg, Gaurav; Gaser, Christian; Gastineau, Edward; Gavidia, Giovana; Gazdzinski, Stefan; Ge, Qi; Gemme, Gianluca; German, Dwight; Ghassabi, Zeinab; Gil, Juan E.; Gill, Ryan; Gitelman, Darren; Gleason, Carey; Godbey, Michael; Goghari, Vina; Gold, Michael; Goldberg, Terry; Gomeni, Roberto; Gong, Shangwenyan; Gonzales, Celedon; Gordon, Brian; Gorriz, Juan Manuel; Grachev, Igor; Grandey, Emily; Grasela, Thaddeus; Gratt, Jeremy; Gray, Katherine; Greenberg, Barry; Gregg, Keith; Gregory, Erik; Greicius, Michael; Greve, Douglas; Grill, Joshua; Gross, Alan; Guo, Lianghao; Guo, Hongbin; Guo, Jeffrey; Habeck, Christian; Hai, Yizhen; Haight, Thaddeus; Hakansson, Kristina; Hammarstrom, Per; Hampel, Harald; Han, Tony; Han, Jian; Hanif, Muhammad; Hanna, Yousef; Hardy, Peter; Hasan, Md Kamrul; Hazart, Aurelien; Hazel, James; He, Yong; He, Huiguang; Head, Denise; Heckemann, Rolf; Heidebrink, Judith; Henderson, David; Henrard, Sebastien; Herholz, Karl; Hernandez, Monica; Hess, Christopher; Hobart, Jeremy; Hoffman, John; Holder, Daniel; Honigberg, Lee; Horsfield, Mark; Hsu, Wei-Wen; Hsu, Ailing; Hu, Zhenghui; Hu, Zhiwei; Hu, Xiaolan; Hu, William; Huang, Shu-Pang; Huang, Chun-Jung; Huang, Fude; Huang, Yifan; Huang, Juebin; Huang, Chingwen; Hubbard, Rebecca; Huentelman, Matthew; Hui, Shen; Huppertz, Hans-Jurgen; Hurko, Orest; Hurt, Stephen; Huyck, Susan; Hwang, Scott; Hyun, JungMoon; Ifeachor, Emmanuel; Iglesias, Martina; Ikari, Yasuhiko; Immermann, Fred; Inoue, Lurdes; Insel, Philip; Irizarry, Michael; Irungu, Benson mwangi; Ishibashi, Taro; Ishii, Kenji; Ismail, Shahina; Ito, Kaori; Ito, Momoyo; Iwatsubo, Takeshi; Iyer, Madhumitha; Jacobson, Mark; Jacobson, Alex; Jafari, Aria; Jafari-Khouzani, Kourosh; Jaffe, Carl; Jagust, William; Jara, Hernan; Jaros, Mark; Jefferson, Angela; Jiang, Tianzi; Johnson, David K.; Juengling, Freimut; Juh, Rahyeong; Julin, Per; Bhaskar, Uday; Kadish, Bill; Kahle-Wrobleski, Kristin; Kallam, Hanimi Reddy; Kalpathy-Cramer, Jayashree; Karageorgiou, Elissaios; Karantzoulis, Stella; Karasev, Peter; Kauwe, John; Kawakami, Hirofumi; Kazimipoor, Borhan; Kelleher, Thomas; Kennedy, Richard; Kerr, Douglas; Kerrouche, Nacer; Khalil, Iya; Khalil, Andre; Khatry, Deepak; Kihel, Badra; Killeen, Neil; Killiany, Ron; Kim, Hyewon; Kim, Heeyoung; Kim, Yeonhee; Kim, Jong Hun; Kimberg, Daniel; Kimura, Tokunori; King, Richard; Kirby, Justin; Kita, Hiroshi; Klimas, Michael; Klopfenstein, Erin; Kobayashi, Dione; Koikkalainen, Juha; Kokomoor, Anders; Kolasny, Anthony; Kondo, Yusuke; Koppel, Jeremy; Korolev, Igor; Kotran, Nickolas; Kouassi, Alex; Koutsouleris, Nikolaos; Kozma, Lynn; Kramer, Joel; Kratzer, Martina; Kuceyeski, Amy; Kuhn, Felix Pierre; Kulkarni, Mauktik; Kumar, Sreedhar; Kuo, Hsun Ting; Kuo, Julie; Kurosawa, Ken; Kwon, Oh Hun; Laforet, Genevieve; Lai, Song; Lakatos, Anita; Landau, Susan; Landen, Jaren; Lane, Richard; Langbaum, Jessica; Lanius, Vivian; Lavault, Romain; Laxamana, Joel; Le, Trung; Leahy, Richard; Lee, Noah; Lee, Vita; Lee, Joseph H.; Lee, Jong-Min; Lee, Dongsoo; Lee, Junyoung; Lefkimmiatis, Stamatis; Lemaitre, Herve; Lenz, Robert; Lester, Gayle; Levey, Allan; Li, Rui; Li, Wenjun; Li, Shanshan; Li, Lexin; Li, Shi-jiang; Li, Gang; Li, Lin; Li, Yi; Li, Jinhe; Li, Chin-Shang; Liang, Peipeng; Liang, Lichen; Liao, Yuan-Lin; Lin, Mingkuan; Lin, Lan; Lin, Ling-chih; Liu, Tao; Liu, Meijie; Liu, Yuan; Liu, Dazhong; Liu, Pu; Liu, Songling; Liu, Xiuwen; Liu, Tianming; Lo, Raymond; Logovinsky, Veronika; Lois, Augusto; Long, Xiaojing; Long, Ziyi; Looi, Jeffrey; Lu, Yuan; Lu, Po-Haong; Lukic, Ana; Lull, Juan J.; Lynch, John; Ma, Lei; Mackin, Scott; Magda, Sebastian; Maglio, Silvio; Mak, Henry Ka-Fung; Malave, Vicente; Mandal, Pravat; Mangin, Jean-Francois; Manohar, Deepak; Mansouri, Chemseddine; Mantri, Ninad; Manzour, Amir; Marambaud, Philippe; Marchewka, Artur; Marek, Kenneth; Markind, Samuel; Marshall, Gad; Martin, Jacob; Mather, Mara; Mathis, Chester; Matoug, Sofia; Matsuo, Yoshiyuki; Matthews, Dawn; Mayo, Agustin; McEvoy, Linda; McGeown, William; McIntyre, John; McQuail, Joseph; Meadowcroft, Mark; Meda, Shashwath; Mehta, Nirav; Mele, Valeria; Mendonca, Brian; Menendez, Manuel; Meredith, Jere; Merrill, David; Mesulam, Marek-Marsel; Meyer, Carsten; Mez, Jesse; Mickael, Guedj; Miftahof, Roustem; Mikhno, Arthur; Miller, David; Min, Ye; Miri, Roham; Mirza, Mubeena; Mitsis, Effie; Mohan, Ananth; Monno, Laura; Montana, Giovanni; Moore, Dana; Birgani, Parmida Moradi; Moratal, David; Morimoto, Bruce; Mortamet, Benedicte; Motyl, Rafal; Mueller, Notger; Mukherjee, Shubhabrata; Mulder, Emma; Murphy, Michael; Murray, Brian; Musiek, Erik; Myers, Amanda; Najafi, Shahla; Nazeri, Arash; Nettiksimmons, Jasmine; Neu, Scott; Neves, Simone; Ng, Yen-Bee; Nguyen, Danh; Nguyen, Nghi; Nguyen Xuan, Tuong; Nielsen, Casper; Nuneez Benjumea, Francisco; O'Neil, Alison; Obisesan, Thomas; Oh, Dong Hoon; Oh, Joonmi; Okonkwo, Ozioma; Olde Rikkert, Marcel; Ollesch, Julian; Olmos, Salvador; Ostrowitzki, Susanne; Oswald, Annahita; Ott, Brian; Ourselin, Sebastien; Ouyang, Gaoxiang; Paiva, Renata; Pan, Zhifang; Pande, Yogesh; Pardoe, Heath; Park, Kee Hyung; Park, Hyunjin; Parsey, Ramin; Parveen, Riswana; Paskavitz, James; Patel, Yogen; Patil, Manasi; Paul, Robert; Pawlak, Mikolaj; Peavy, Guerry; Peng, Yahong; Pepin, Jean louis; Perea, Rodrigo; Perneczky, Robert; Petitti, Diana; Petrella, Jeffrey; Peyrat, Jean-Marc; Pezoa, Jorge; Pham, Chi-Tuan; Phillips, Nicole; Piovezan, Mauro; Podhorski, Adam; Pollari, Mika; Pontecorvo, Michael; Poppenk, Jordan; Posner, Holly; Potkin, Steven; Poulin, Stephane; Prasad, Gautam; Prenger, Kurt; Prieto, Elena; Prince, Jerry; Puchakayala, Shashidhar Reddy; Qin, Wei; Qiu, Ruolun; Qiu, Wendy; Qiu, Anqi; Qualls, Constance Dean; Rabie, Huwaida; Rajeesh, Rajeesh; Rajeesh, J. Rajeesh; Rallabandi, V. P. Subramanyam; Ramage, Amy; Randolph, Christopher; Raniga, Parnesh; Rao, Divya; Rao, Anil; Raubertas, Richard; Ray, Debashis; Razak, Hana; Redolfi, Alberto; Reid, Andrew; Reilhac, Anthonin; Reinsberger, Claus; Restrepo, Lucas; Retico, Alessandra; Rezaeitabar, Yousef; Richards, John; Richter, Mirco; Riddle, William; Ries, Michele; Rincon, Mariano; Rischall, Matt; Robieson, Weining; Rocha-Rego, Vanessa; Rogalski, Emily; Rogers, Elizabeth; Rojas, Ignacio; Romero, Klaus; Rosand, Jonathan; Rosen, Ori; Rosen, Allyson; Rosenberg, Paul; Ross, David; Ross, Joel; Rousseau, Francois; Rowe, Christopher; Rubin, Daniel; Ruiz, Agustin; Rusinek, Henry; Ryan, Laurie; Saad, Ahmed; Sabbagh, Marway; Sabuncu, Mert; Sachs, Michael; Sacuiu, Simona; Sadeghi, Ali; Said, Yasmine; Saint-Aubert, Laure; Sakata, Muneyuki; Salat, David; Salmon, David; Salomi, Sharmila; Salter, Hugh; Samwald, Matthias; Sanchez, Luciano; Sanjo, Nobuo; Sankaranarayanan, Preethi; Sato, Shinji; Sato, Hajime; Saumier, Daniel; Savio, Alexandre; Sawada, Ikuhisa; Saykin, Andrew; Schaffer, J. David; Scharre, Douglas; Schlosser, Gretchen; Schmand, Ben; Schmansky, Nick; Schmidt, Mark; Schneider, Lon; Schramm, Hauke; Schuerch, Markus; Schwartz, Eben; Schwartz, Craig; Schwarz, Adam; Seethamraju, Ravi; Seixas, Flavio; Selnes, Per; Senjem, Matthew; Senlin, Wang; Seo, Sang Won; Sethuraman, Gopalan; Sevigny, Jeffrey; Sfikas, Giorgos; Shahbaba, Babak; Shams, Soheil; Shankle, William; Shattuck, David; Shaw, Leslie; Sheela, Jaba; Shen, Weijia; Shera, David; Sherman, John; Sherman, Michelle; Sherva, Richard; Shimizu, Keiji; Shuler, Catherine; Shulman, Joshua; Siegel, Rene; Siemers, Eric; Silveira, Margarida; Silver, Michael; Silverman, Daniel; Simmons, Andy; Simpson, Ivor; Singh, Simer Preet; Singh, Nikhil; Siuciak, Judy; Sjogren, Niclas; Skup, Martha; Small, Gary; Smith, Benjamin; Smith, Michael; Smith, Charles; Smyth, Timothy; Snow, Sarah; Soares, Holly; Soldea, Octavian; Solomon, Paul; Solomon, Alan; Song, Mingli; Song, Changhong; Sorensen, Greg; Soudah, Eduardo; Spampinato, Maria Vittoria; Spenger, Christian; Sperling, Reisa; Spiegel, Rene; Spies, Lothar; Squarcia, Sandro; Squire, Larry; Staff, Roger; Stern, Yaakov; Strittmatter, Stephen; Styren, Scot; Sugishita, Morihiro; Sugishita, Kazuyuki; Sukkar, Rafid; Sun, Jia; Sun, Yu; Sundell, Karen; Suri, Muhammad; Swan, Melanie; Takagi, Toshihisa; Takahasi, Tetsuhiko; Takeuchi, Tomoko; Tang, Songyuan; Tanner, William; Tao, Wenwen; Tao, Dacheng; Tariot, Pierre; Tarjoman, Mana; Tatsuoka, Curtis; Taylor-Reinwald, Lisa; Terlizzi, Rita; Thiele, Frank; Thomas, Ronald; Thomas, Benjamin; Thompson, Paul; Thompson, Wesley; Thornton-Wells, Tricia; Thurfjell, Lennart; Titeux, Laurence; Tolli, Tuomas; Toma, Ahmed; Tomita, Naoki; Toro, Roberto; Tosun, Duygu; Toussaint, Paule; Toyoshiba, Hiroyoshi; Tractenberg, Rochelle E.; Trittschuh, Emily; Truran, Diana; Tsechpenakis, Gavriil; Tucker-Drob, Elliot; Tung, Joyce; Uesugi, Humito; Ullrich, Lauren; Umadevi Venkataraju, Kannan; Umar, Nisser; Uzunbas, Gokhan; Valdivia, Fernando; van Horn, John; van Leemput, Koen; van Train, Kenneth; van Zeeland, Ashley; Vargas, Gabriel; Vasanawala, Minal; Vemuri, Prashanthi; Verwaerde, Philippe; Videbaek, Charlotte; Vidoni, Eric; Vigneron, Vincent; Villanueva-Meyer, Javier; Visser, Pieter Jelle; Vitolo, Ottavio; Vlassenko, Andrei; Volkau, Ihar; Vounou, Maria; Wade, Sara; Walhovd, Kristine B.; Wallace, Douglas; Wan, Hong; Wang, Angela; Wang, Li-San; Wang, Yongmei Michelle; Wang, Yaping; Wang, Alex; Wang, Lubin; Wang, Yalin; Wang, Tiger; Wang, Yue; Wang, Huanli; Wang, Huali; Ward, Michael; Warfield, Simon; Waring, Stephen; Webb, David; Wei, Lili; Wen, Shu-Hui; Wenjing, Li; Wenzel, Fabian; Westlye, Lars T.; Whitcher, Brandon; Whitwell, Jennifer; WilliamFaltaos, Demiana; Williams, David; Wilmot, Beth; Wingo, Thomas; Winkler, Andreas; Wiste, Heather; Wolfson, Tanya; Wolke, Ira; Wolz, Robin; Woo, Jongwook; Woo, Ellen; Woods, Lynn; Worth, Andrew; Worth, Eric; Wouters, Hans; Wu, Liang; Wu, Xiaoling; Wu, Yi Gen; Wu, Teresa; Wyman, Bradley; Wyss-Coray, Tony; Xiao, Liu; Xu, Guofan; Xu, Jun; Yamane, Tomohiko; Yamashita, Fumio; Yamazawa, Maki; Yan, Yunyi; Yan, Pingkun; Yang, Qing X.; Yang, Zhitong; Ye, Byoung Seok; Ye, Jieping; Yee, Laura; Yesavage, Jerome; Yip, WaiKuan; Yoo, Bongin; Yuan, Kai; Yushkevich, Paul; Zagorodnov, Vitali; Zagorski, Michael; Zawadzki, Rezi; Zeitzer, Jamie; Zhang, Linda; Zhang, Lijun; Zhang, Tianhao; Zhang, Huixiong; Zhang, Bin; Zhang, Kurt; Zhao, Qinying; Zhao, Peng; Zhen, Xiantong; Zheng, Yuanjie; Zhijun, Yao; Zhou, Sheng; Zhou, Bin; Zhou, Luping; Zhu, Wanlin; Zhu, Hongtu; Zou, Heng

    2010-01-01

    To evaluate relationships between magnetic resonance imaging (MRI)-based measures of white matter hyperintensities (WMHs), measured at baseline and longitudinally, and 1-year cognitive decline using a large convenience sample in a clinical trial design with a relatively mild profile of

  19. Prognosis of HIV-1-infected patients up to 5 years after initiation of HAART: collaborative analysis of prospective studies

    NARCIS (Netherlands)

    May, Margaret; Sterne, Jonathan A. C.; Sabin, Caroline; Costagliola, Dominique; Justice, Amy C.; Thiébaut, Rodolphe; Gill, John; Phillips, Andrew; Reiss, Peter; Hogg, Robert; Ledergerber, Bruno; D'Arminio Monforte, Antonella; Schmeisser, Norbert; Staszewski, Shlomo; Egger, Matthias

    2007-01-01

    OBJECTIVE: To estimate the prognosis over 5 years of HIV-1-infected, treatment-naive patients starting HAART, taking into account the immunological and virological response to therapy. DESIGN: A collaborative analysis of data from 12 cohorts in Europe and North America on 20,379 adults who started

  20. Initial epidemic area is strongly associated with the yearly extent of soybean rust spread in North America.

    Science.gov (United States)

    Mundt, Christopher C; Wallace, Larae D; Allen, Tom W; Hollier, Clayton A; Kemerait, Robert C; Sikora, Edward J

    2013-07-01

    Hosts of soybean rust ( Phakopsora pachyrhizi ) are sensitive to low temperatures, limiting this obligate parasite in the United States to overwintering sites in a restricted area along the Gulf Coast. This temperature sensitivity of soybean rust hosts allowed us to study spatial spread of epidemic invasions over similar territory for seven sequential years, 2005-2011. The epidemic front expanded slowly from early April through July, with the majority of expansion occurring from August through November. There was a 7.4-fold range of final epidemic extent (0.4 to 3.0 million km 2 ) from the year of smallest final disease extent (2011) to that of the largest (2007). The final epidemic area of each year was regressed against epidemic areas recorded at one-week intervals to determine the association of final epidemic extent with current epidemic extent. Coefficients of determination for these regressions varied between 0.44 to 0.62 during April and May. The correlation coefficients varied between 0.70 and 0.96 from early June through October, and then increased monotonically to 1.0 by year's end. Thus, the spatial extent of disease when the epidemics began rapid expansion may have been a crucial contributor to subsequent spread of soybean rust. Our analyses used presence/absence data at the county level to evaluate the spread of the epidemic front only; the subsequent local intensification of disease could be strongly influenced by other factors, including weather.

  1. An Initial Examination of Facebook as a Source of Memorable Messages for First-Year College Students

    Science.gov (United States)

    Russell, Jessica; Nazione, Samantha; Smith, Sandi

    2012-01-01

    This study investigated a set of messages on a university group's Facebook page intended as advice for first-year college students. Investigators coded 108 different units of advice into three overarching categories focused on academics, the transition to college life, and comprehension of the college campus. Messages transmitted were similar in…

  2. Cross-polarization and sidelobe suppression in dual linear polarization antenna arrays

    DEFF Research Database (Denmark)

    Woelders, Kim; Granholm, Johan

    1997-01-01

    In recent years, there has been an increasing interest in dual linear polarization antennas for various purposes, e.g. polarimetric synthetic aperture radar (SAR) imaging. A key design goal for dual polarization antennas is to obtain a high cross-polarization suppression. When using standard tech...

  3. Costs and Resource Utilization for Diagnosis and Treatment During the Initial Year in a European Inflammatory Bowel Disease Inception Cohort

    DEFF Research Database (Denmark)

    Burisch, J.; Vardi, Hillel; Pedersen, Natalia

    2015-01-01

    ( €72) (P = 0.51). CONCLUSIONS: In this population-based unselected cohort, costs during the first year of disease were mainly incurred by investigative procedures and surgeries. However, biologicals accounted for >15% of costs. Long-term follow-up of the cohort is needed to assess the cost......BACKGROUND: No direct comparison of health care cost in patients with inflammatory bowel disease across the European continent exists. The aim of this study was to assess the costs of investigations and treatment for diagnostics and during the first year after diagnosis in Europe. METHODS: The Epi......Com cohort is a prospective population-based inception cohort of unselected inflammatory bowel disease patients from 31 Western and Eastern European centers. Patients were followed every third month from diagnosis, and clinical data regarding treatment and investigations were collected. Costs were calculated...

  4. A case of thyrotoxic periodic paralysis as initial manifestation of Graves' disease in a 16-year-old Korean adolescent

    Directory of Open Access Journals (Sweden)

    Se Yong Jung

    2014-09-01

    Full Text Available Thyrotoxic periodic paralysis (TPP is a rare complication of hyperthyroidism, with recurrent muscle paralysis and hypokalemia that are caused by an intracellular shift of potassium. TPP is relatively common in Asian males, but is extremely rare in children and adolescents, even for those of Asian descent. We describe a 16-year-old Korean adolescent presenting with a two-week history of episodic leg weakness in the morning. He showed sinus tachycardia, lower leg weakness, and hypokalemia. Thyroid function test showed hyperthyroidism, and thyroid ultrasonography revealed a diffuse enlarged thyroid with increased vascularity, consistent with Graves' disease. He was treated with β-adrenergic blocker and antithyroid drugs. He has been symptom free for one year, as his hyperthyroidism has been controlled well with antithyroid drugs. TPP should be considered in children and adolescents with acute paralysis of the lower extremities and hypokalemia.

  5. Policy initiatives by the Government of India to accelerate growth of nuclear installed capacity in the coming years

    International Nuclear Information System (INIS)

    Grover, R.B.

    2010-01-01

    When examined from the point of view of the size of its population and economy, India is not well endowed with energy resources. Studies done by the Department of Atomic Energy indicate that even after exploiting full potential of every available source of energy including nuclear energy, India needs to continue to import energy resources. In this backdrop, an initiative was launched by Government of India to open up international civil nuclear commerce so as to enable India to access natural uranium from international market and to set up nuclear reactors in technical cooperation with other countries. International civil nuclear trade is governed by guidelines of Nuclear Suppliers Group (NSG) and its guidelines, as they were, required all nuclear materials and facilities in the recipient country, other than those identified as Nuclear Weapon States in the Treaty for Non-Proliferation of Nuclear Weapons, to be under Comprehensive Safeguards of the International Atomic Energy Agency (IAEA). The civil nuclear initiative of the Government of India involved having a dialogue with several NSG members; negotiating agreements of cooperation in peaceful uses of nuclear energy with France, Russia and USA; formulating a plan separating certain nuclear facilities and a timetable for offering them, in a phased manner, to IAEA for implementation of safeguards; and negotiating an India-specific safeguards agreement with IAEA. As a result of all these steps, the guidelines for civil nuclear cooperation were modified by the NSG on 6th September 2008 to facilitate nuclear trade with India without the condition of Comprehensive Safeguards. India has since been able to import uranium and dialogue is ongoing with France, Russia and the USA to set up, with their technical cooperation, light water reactors at selected sites. To facilitate international civil nuclear trade, a policy resolution has also been issued and The Civil Nuclear Liability for Nuclear Damage Bill 2010 is under

  6. [An Elderly Patient with Pilocytic Astrocytoma Operated on 14 Years after Initial Detection:A Case Study].

    Science.gov (United States)

    Isobe, Naoyuki; Nishimoto, Takeshi; Ueda, Takeshi

    2017-08-01

    Pilocytic astrocytomas are found predominantly in the pediatric population and are extremely rare in elderly patients. We describe a case of pilocytic astrocytoma in an elderly patient who presented with the symptoms of an enlarged tumoral cyst. A 70-year-old woman was found to have an asymptomatic small solid tumor with a cystic component in the right frontal lobe at "Ningen Dock(medical checkup)of the Brain". She was hospitalized and underwent further examinations including cerebral angiography. At that time, she was opposed to undergoing an operation for tumor removal owing to lack of symptoms. Approximately fourteen years later, she presented with dizziness upon posture conversion and recent memory disturbance. Computed tomography scanning revealed an enlarged cyst in the frontal lobe and perifocal edematous changes. Gadolinium-enhanced magnetic resonance imaging partially revealed the solid tumor and cystic capsule. The solid tumor had not enlarged substantially. The cystic fluid was aspirated and the solid tumor was resected via a frontal transcortical approach. The histological diagnosis was pilocytic astrocytoma without malignant features. After surgery, the patient's symptoms improved and additional therapy was not provided. After a year of postoperative follow-up, the size of the cystic lesion has reduced, and no recurrence of the solid tumor has been observed.

  7. DISCOVERY OF POLARIZATION REVERBERATION IN NGC 4151

    Energy Technology Data Exchange (ETDEWEB)

    Gaskell, C. Martin; Shoji, Masatoshi [Department of Physics and Astronomy, University of Nebraska, Lincoln, NE 68588-0111 (United States); Goosmann, Rene W. [Observatoire astronomique de Strasbourg, 11 rue de l' Universite, F-67000 Strasbourg (France); Merkulova, Nelly I.; Shakhovskoy, Nikolay M., E-mail: martin.gaskell@uv.cl, E-mail: mshoji@astro.as.utexas.edu, E-mail: rene.goosmann@astro.unistra.fr [Crimean Astrophysical Observatory, Nauchny, Crimea 98409 (Ukraine)

    2012-04-20

    Observations of the optical polarization of NGC 4151 in 1997-2003 show variations of an order of magnitude in the polarized flux while the polarization position angle remains constant. The amplitude of variability of the polarized flux is comparable to the amplitude of variability of the total U-band flux, except that the polarized flux follows the total flux with a lag of 8 {+-} 3 days. The time lag and the constancy of the position angle strongly favor a scattering origin for the variable polarization rather than a non-thermal synchrotron origin. The orientation of the position angle of the polarized flux (parallel to the radio axis) and the size of the lag imply that the polarization arises from electron scattering in a flattened region within the low-ionization component of the broad-line region. Polarization from dust scattering in the equatorial torus is ruled out as the source of the lag in polarized flux because it would produce a larger lag and, unless the half-opening angle of the torus is >53 Degree-Sign , the polarization would be perpendicular to the radio axis. We note a long-term change in the percentage of polarization at similar total flux levels, and this could be due either to changing non-axisymmetry in the optical continuum emission or a change in the number of scatterers on a timescale of years.

  8. Growth and Mortality Outcomes for Different Antiretroviral Therapy Initiation Criteria in Children Ages 1-5 Years: A Causal Modeling Analysis.

    Science.gov (United States)

    Schomaker, Michael; Davies, Mary-Ann; Malateste, Karen; Renner, Lorna; Sawry, Shobna; N'Gbeche, Sylvie; Technau, Karl-Günter; Eboua, François; Tanser, Frank; Sygnaté-Sy, Haby; Phiri, Sam; Amorissani-Folquet, Madeleine; Cox, Vivian; Koueta, Fla; Chimbete, Cleophas; Lawson-Evi, Annette; Giddy, Janet; Amani-Bosse, Clarisse; Wood, Robin; Egger, Matthias; Leroy, Valeriane

    2016-03-01

    There is limited evidence regarding the optimal timing of initiating antiretroviral therapy (ART) in children. We conducted a causal modeling analysis in children ages 1-5 years from the International Epidemiologic Databases to Evaluate AIDS West/Southern-Africa collaboration to determine growth and mortality differences related to different CD4-based treatment initiation criteria, age groups, and regions. ART-naïve children of ages 12-59 months at enrollment with at least one visit before ART initiation and one follow-up visit were included. We estimated 3-year growth and cumulative mortality from the start of follow-up for different CD4 criteria using g-computation. About one quarter of the 5,826 included children was from West Africa (24.6%).The median (first; third quartile) CD4% at the first visit was 16% (11%; 23%), the median weight-for-age z-scores and height-for-age z-scores were -1.5 (-2.7; -0.6) and -2.5 (-3.5; -1.5), respectively. Estimated cumulative mortality was higher overall, and growth was slower, when initiating ART at lower CD4 thresholds. After 3 years of follow-up, the estimated mortality difference between starting ART routinely irrespective of CD4 count and starting ART if either CD4 count <750 cells/mm³ or CD4% <25% was 0.2% (95% CI = -0.2%; 0.3%), and the difference in the mean height-for-age z-scores of those who survived was -0.02 (95% CI = -0.04; 0.01). Younger children ages 1-2 and children in West Africa had worse outcomes. Our results demonstrate that earlier treatment initiation yields overall better growth and mortality outcomes, although we could not show any differences in outcomes between immediate ART and delaying until CD4 count/% falls below 750/25%.

  9. Geomagnetic polarity transitions

    Science.gov (United States)

    Merrill, Ronald T.; McFadden, Phillip L.

    1999-05-01

    reasonable to draw the following conclusions with varying degrees of confidence. There appears to be a substantial decrease in the mean intensity of the dipole field during a transition to ˜25% of its usual value. The duration of an average geomagnetic polarity transition is not well known but probably lies between 1000 and 8000 years. Values outside these bounds have been reported, but we give reasons as to why such outliers are likely to be artifacts. The reversal process is probably longer than the manifestation of the reversal at Earth's surface as recorded in paleomagnetic directional data. Convection hiatus during a geomagnetic polarity transition seems unlikely, and free-decay models for reversals appear to be generally incompatible with the data. This implies that certain theorems in dynamo theory, such as Cowling's theorem, should not be invoked to explain the origin of reversals. Unfortunately, the detailed description of directional changes during transitions remains controversial. Contrary to common belief, certain low-degree nondipole fields can produce significant longitudinal confinement of virtual geomagnetic poles (VGP) during a transition. The data are currently inadequate to refute or verify claims of longitudinal dipole confinement, VGP clustering, or other systematics during polarity transitions.

  10. Incidence of fractures of the femur, including subtrochanteric, up to 8 years since initiation of oral bisphosphonate therapy

    DEFF Research Database (Denmark)

    Pazianas, M; Abrahamsen, B; Wang, Y

    2012-01-01

    In a cohort study of users of bisphosphonates, we evaluated the incidence of fragility fractures at all sites on the femur following for up to 8 years of therapy with alendronate or risedronate. We did not find evidence for a reversal of fracture protection with long-term use of bisphosphonates....... INTRODUCTION: Few studies have acquired adequate data with prolonged follow-up on bisphosphonate users in the general population to evaluate their long-term effects on the risk of hip fractures including those in the subtrochanteric region. METHODS: This cohort study utilizes a large USA database (January 1...

  11. Steel and Aluminum Energy Conservation and Technology Competitiveness Act of 1988: Annual report of the metals initiative for fiscal year 1996

    International Nuclear Information System (INIS)

    1998-01-01

    This annual report has been prepared for the President and Congress describing the activities carried out under the Steel and Aluminum Energy Conservation and Technology Competitiveness Act of 1988, commonly referred to as the Metals Initiative. The Act has the following purposes: (1) increase energy efficiency and enhance the competitiveness of the American steel, aluminum, and copper industries; and (2) continue research and development efforts begun under the U.S. Department of Energy (DOE) program known as the Steel Initiative. These activities are detailed in a subsequent section. Other sections describe the appropriation history, the distribution of funds through fiscal year 1996, and the estimated funds necessary to continue projects through fiscal year 1997. The Metals Initiative supported four research and development projects with the U.S. Steel industry: (1) steel plant waste oxide recycling and resource recovery by smelting, (2) electrochemical dezincing of steel scrap, (3) rapid analysis of molten metals using laser-produced plasmas, and (4) advanced process control. There are three Metals Initiative projects with the aluminum industry: (1) evaluation of TiB2-G cathode components, (2) energy efficient pressure calciner, and (3) spray forming of aluminum. 1 tab

  12. Lessons Learned from 50+ Years of NSF-Funded Geoscience Teacher Education Initiatives at Michigan Technological University

    Science.gov (United States)

    Klawiter, M.; Klawiter, F.

    2011-12-01

    Michigan Technological University has a long and successful tradition of coupling its spectacular geological setting with a dedicated faculty and staff in efforts to improve geoscience education. Beginning with a National Science Foundation Summer Institute in 1960 and culminating in MiTEP (Michigan Teacher Excellence Program, a NSF-funded Math-Science Partnership) now in midcourse, the presenter will focus on many facets of planning, implementation, and evaluation of several successful MTU Geoscience Education programs funded by NSF. Featuring personal accounts and reminiscences of involvement (beginning in 1960) as an attendee, teacher participant, evaluator, pedagogy consultant, and finally as a graduate student contributing to the planning of NSF-funded professional development activities at Michigan Technological University, the presenter will discuss how a consideration of prior program designs has led to a synthesis of successful strategies employed in MiTEP, including: -Addressing teachers' needs based upon pre-assessments in the planning and implementation of high-quality professional development activities -The employment of extensive and varied field-based learning experiences in expanding teachers' content knowledge -The importance of pedagogy in stimulating improvement in course content -Place-based design -Sustainability of lessons learned through sharing methods (such as lesson study, professional learning communities, and participation in conferences conducted by professional organizations) -Incorporation of resources and initiatives from state and federal agencies and organizations into the design and implementation plan (e.g. ESLP Big Ideas, state and federal academic standards, EarthComm) -Evaluation of program effectiveness and implementation of corrections and/or enhancements based upon critical evaluative feedback -Communication of lessons learned

  13. A Rare Presentation of the Syndrome of Inappropriate Antidiuretic Hormone in a 12-Year-Old Girl as the Initial Presentation of an Immature Ovarian Teratoma.

    Science.gov (United States)

    Iqbal, Anoop Mohamed; Schwenk, W Frederick

    2018-02-01

    Immature ovarian teratoma is very rare in childhood. We report on a 12-year-old girl with immature ovarian teratoma who presented initially with syndrome of inappropriate antidiuretic hormone. A 12-year-old girl presented with acute abdomen and distention. Initial laboratory tests showed hyponatremia (sodium, 123 mmol/L), that did not respond to fluid management. Computed tomography imaging showed a 15 cm × 9 cm × 20 cm mass in the right ovary with multifocal internal fat, and dystrophic calcifications. She underwent exploratory laparotomy with a right salpingo-oophorectomy, omentectomy, and peritoneal stripping. The pathology revealed metastatic immature teratoma. Hyponatremia resolved soon after the surgery. Although a rare diagnosis, immature ovarian teratoma must be considered in a girl who presents with abdominal mass and hyponatremia. Copyright © 2017 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc. All rights reserved.

  14. Reversible Shaping of Microwells by Polarized Light Irradiation

    Directory of Open Access Journals (Sweden)

    Federica Pirani

    2017-01-01

    Full Text Available In the last years, stimuli-responsive polymeric materials have attracted great interest, due to their low cost and ease of structuration over large areas combined with the possibility to actively manipulate their properties. In this work, we propose a polymeric pattern of soft-imprinted microwells containing azobenzene molecules. The shape of individual elements of the pattern can be controlled after fabrication by irradiation with properly polarized light. By taking advantage of the light responsivity of the azobenzene compound, we demonstrate the possibility to reversibly modulate a contraction-expansion of wells from an initial round shape to very narrow slits. We also show that the initial shape of the microconcavities can be restored by flipping the polarization by 90°. The possibility to reversibly control the final shape of individual elements of structured surfaces offers the opportunity to engineer surface properties dynamically, thus opening new perspectives for several applications.

  15. Pauci-Immune Necrotizing and Crescentic Glomerulonephritis with Membranous Lupus Nephritis, Fifteen Years after Initial Diagnosis of Secondary Membranous Nephropathy

    Directory of Open Access Journals (Sweden)

    Ryan Burkhart

    2015-01-01

    Full Text Available Renal involvement in systemic lupus erythematosus (SLE is usually immune complex mediated and may have multiple different presentations. Pauci-immune necrotizing and crescentic glomerulonephritis (NCGN refers to extensive glomerular inflammation with few or no immune deposits that may result in rapid decline in renal function. We report a case of a 79-year-old Hispanic male with a history of secondary membranous nephropathy (diagnosed by renal biopsy 15 years previously who was admitted with acute kidney injury and active urinary sediment. P-ANCA titers and anti-myeloperoxidase antibodies were positive. The renal biopsy was diagnostic for NCGN superimposed on a secondary membranous nephropathy. A previous diagnosis of SLE based on American College of Rheumatology criteria was discovered via Veteran’s Administration records review after the completion of treatment for pauci-immune NCGN. ANCAs are detected in 20–31% of patients with SLE. There may be an association between SLE and ANCA seropositivity. In patients with lupus nephritis and biopsy findings of necrotizing and crescentic glomerulonephritis, without significant immune complex deposition, ANCA testing should be performed. In patients with secondary membranous nephropathy SLE should be excluded.

  16. The national neonatal screening programme for congenital toxoplasmosis in Denmark: results from the initial four years, 1999-2002

    DEFF Research Database (Denmark)

    Schmidt, Dorte Remmer; Høgh, Birthe; Andersen, O

    2006-01-01

    AIMS: To describe the outcome of four years' nationwide neonatal screening for congenital toxoplasmosis in liveborn newborns. METHODS: Congenital toxoplasmosis was diagnosed if specific Toxoplasma gondii IgM antibodies were detected in eluate from the PKU Guthrie filter paper card from a child....... Infants diagnosed with congenital toxoplasmosis were examined for intracranial and retinal lesions and treated for three months with sulphadiazine, pyrimethamine, and folinic acid continuously. RESULTS: Eluates from PKU-cards from 262 912 newborns were analysed. The birth prevalence of congenital...... toxoplasma infection was 2.1 per 10 000 liveborns. Congenital toxoplasmosis was suspected in 96 infants and confirmed in 55. Forty seven children were examined for intracranial and retinal lesions soon after birth; 12 had clinical signs at this first examination. Of these, 5 had intracranial calcifications...

  17. Four-Year Durability of Initial Combination Therapy with Sitagliptin and Metformin in Patients with Type 2 Diabetes in Clinical Practice; COSMIC Study.

    Directory of Open Access Journals (Sweden)

    Eu Jeong Ku

    Full Text Available We investigated the efficacy of initial combination therapy with sitagliptin and metformin in patients with type 2 diabetes for 4 years in clinical practice.Between 2009 and 2010, we reviewed 1,178 patients with type 2 diabetes (HbA1c ≥7.5% or 58 mmol/mol prescribed initial combination therapy with sitagliptin and metformin. After excluding 288 patients without a second follow-up, 890 individuals (age, 58.0 ± 12.5 years; BMI, 25.4 ± 3.5 kg/m2; HbA1c, 8.6 ± 1.1% were followed up with every 3-6 months for 4 years. Homeostasis model assessments for insulin resistance and β-cell function (HOMA-β were recorded at baseline. The response criterion was HbA1c reduction by ≥0.8% from baseline or attainment of the target HbA1c (≤7.0% or 53 mmol/mol. At the end of every year of treatment, changes in HbA1c from the baseline were assessed.After 1 year, 72.2% of patients with initial combination therapy had responded, defined as HbA1c reduction ≥0.8% or attainment of the target HbA1c ≤7.0%. After 4 years, 35.4% of the patients still showed a response, with an HbA1c level of 7.0 ± 0.9%. A high HbA1c level at baseline was the most significant independent predictor of the long-term response (P<0.001. In addition, low HOMA-β was a significant predictor of a greater reduction in HbA1c. This treatment was generally well tolerated over the 4-year follow-up period, without any serious adverse events.This real-world follow-up study shows a persistent glucose-reducing effect of initial combination therapy with sitagliptin and metformin for up to 4 years.

  18. Twenty-Eight Years of Poliovirus Replication in an Immunodeficient Individual: Impact on the Global Polio Eradication Initiative.

    Directory of Open Access Journals (Sweden)

    Glynis Dunn

    2015-08-01

    Full Text Available There are currently huge efforts by the World Health Organization and partners to complete global polio eradication. With the significant decline in poliomyelitis cases due to wild poliovirus in recent years, rare cases related to the use of live-attenuated oral polio vaccine assume greater importance. Poliovirus strains in the oral vaccine are known to quickly revert to neurovirulent phenotype following replication in humans after immunisation. These strains can transmit from person to person leading to poliomyelitis outbreaks and can replicate for long periods of time in immunodeficient individuals leading to paralysis or chronic infection, with currently no effective treatment to stop excretion from these patients. Here, we describe an individual who has been excreting type 2 vaccine-derived poliovirus for twenty eight years as estimated by the molecular clock established with VP1 capsid gene nucleotide sequences of serial isolates. This represents by far the longest period of excretion described from such a patient who is the only identified individual known to be excreting highly evolved vaccine-derived poliovirus at present. Using a range of in vivo and in vitro assays we show that the viruses are very virulent, antigenically drifted and excreted at high titre suggesting that such chronic excreters pose an obvious risk to the eradication programme. Our results in virus neutralization assays with human sera and immunisation-challenge experiments using transgenic mice expressing the human poliovirus receptor indicate that while maintaining high immunisation coverage will likely confer protection against paralytic disease caused by these viruses, significant changes in immunisation strategies might be required to effectively stop their occurrence and potential widespread transmission. Eventually, new stable live-attenuated polio vaccines with no risk of reversion might be required to respond to any poliovirus isolation in the post

  19. Twenty-Eight Years of Poliovirus Replication in an Immunodeficient Individual: Impact on the Global Polio Eradication Initiative

    Science.gov (United States)

    Dunn, Glynis; Klapsa, Dimitra; Wilton, Thomas; Stone, Lindsay; Minor, Philip D.; Martin, Javier

    2015-01-01

    There are currently huge efforts by the World Health Organization and partners to complete global polio eradication. With the significant decline in poliomyelitis cases due to wild poliovirus in recent years, rare cases related to the use of live-attenuated oral polio vaccine assume greater importance. Poliovirus strains in the oral vaccine are known to quickly revert to neurovirulent phenotype following replication in humans after immunisation. These strains can transmit from person to person leading to poliomyelitis outbreaks and can replicate for long periods of time in immunodeficient individuals leading to paralysis or chronic infection, with currently no effective treatment to stop excretion from these patients. Here, we describe an individual who has been excreting type 2 vaccine-derived poliovirus for twenty eight years as estimated by the molecular clock established with VP1 capsid gene nucleotide sequences of serial isolates. This represents by far the longest period of excretion described from such a patient who is the only identified individual known to be excreting highly evolved vaccine-derived poliovirus at present. Using a range of in vivo and in vitro assays we show that the viruses are very virulent, antigenically drifted and excreted at high titre suggesting that such chronic excreters pose an obvious risk to the eradication programme. Our results in virus neutralization assays with human sera and immunisation-challenge experiments using transgenic mice expressing the human poliovirus receptor indicate that while maintaining high immunisation coverage will likely confer protection against paralytic disease caused by these viruses, significant changes in immunisation strategies might be required to effectively stop their occurrence and potential widespread transmission. Eventually, new stable live-attenuated polio vaccines with no risk of reversion might be required to respond to any poliovirus isolation in the post-eradication era. PMID:26313548

  20. Predictors and Timing of ATT Initiation among HIV-TB Patients at ART Centers of Karnataka, India: Two Year Follow-Up.

    Directory of Open Access Journals (Sweden)

    Suresh Shastri

    Full Text Available In India, TB and HIV co-infection remains as a serious public health problem. From 2006 onwards, the intensified TB-HIV collaborative activities are being jointly implemented by National AIDS Control Programme (NACP and Revised National TB Control programme (RNTCP at high HIV burden states.To determine (a the predictors of outcome among a cohort of HIV-TB co-infected patients after two years after initiation of ART treatment. (b prognostic significance of time difference between the initiation of ATT and ART in HIV-TB co-infected patients.Patients registered at sixteen ART centres in Karnataka, from October through December 2009 formed the study cohort and were followed till December 2011.A total of 604 HIV-TB patients were registered. Follow-up (a at the end of one year had shown 63.6% (377patients with unfavorable TB treatment outcomes (b at the end of second year, 55.6% (336patients were alive on ART treatment. The variables male, smear negative TB, CD4 count less than 50cells per cumm and unfavorable TB outcome were significantly associated with unfavorable ART treatment outcome.The programmes need to review the existing strategies and strengthen HIV-TB collaborative activities for timely treatment initiation with intensive monitoring of HIV-TB patients on treatment.

  1. Cycling of 137Cs in soil and vegetation of a flood plain 30 years after initial contamination

    International Nuclear Information System (INIS)

    Dahlman, R.C.; Van Voris, P.

    1976-01-01

    Distribution of radiocesium was determined in soil and vegetation components of a flood plain contaminated by Manhattan Project operations in 1944. Thirty years after contaminated waste effluents were deposited in a temporary holding basin, practically all the soil 137 Cs was still within 60 cm of the soil surface. Maximum 137 Cs concentrations occurred in the 12- to 22-cm horizon. Concentrations throughout the flood plain were variable; maximum levels of 137 Cs exceeded 20,000 pCi/g; intermediate levels of 5,000 to 20,000 pCi/g were encountered along the watercourse, and concentrations less than 5,000 pCi/g were found along the flood plain margins. Relative concentrations in soil, roots and aboveground vegetation (expressed as ratios on a gram per gram basis) were 0.6 for root/soil, 0.03 for aboveground vegetation/soil, and 0.04 for aboveground vegetation/roots. Vegetation-soil ratios ranged from 0.001 to 0.53 for all species, and average ratios for the 30-yr postcontamination study showed that the relative 137 Cs distribution between plants and soil has not changed from distributions reported 15 yr ago. The results also indicated that ratios were higher at low soil- 137 Cs concentration. Thus, when soil and environmental conditions remain unchanged over a 30-yr period, the relative concentration of 137 Cs between plants and soil does not appear to change as a function of time

  2. Status of annual plant species in the Baneberry fallout pattern first and sixth years after initial irradiation

    International Nuclear Information System (INIS)

    Rhoads, W.A.

    1977-01-01

    At Project Baneberry on December 18, 1970, there was an accidental venting of radioactive debris into the environment which resulted in the irradiation of vegetation about 1.5 km to the north with doses estimated to reach a maximum of 6.2 K rads, beta plus gamma. At the highest doses, 35 percent of the dominant shrub in the area, Coleogyne (black brush), were killed and 65% severely damaged; and at lesser doses there was correspondingly less damage. Other species of shrubs were also affected. Grayia spinosa showed a low frequency of stem fasciation at the higher doses as well as other manifestations of radiation damage. In June 1971, the annual plant species which were probably small seedlings at fallout time were more frequently absent from the higher radiation areas than in the lower. At the same time, there was a greater frequency of higher dry weights produced by annuals at the higher radiation exposures. The frequency of occurrence of annuals varied from means of 8.5/m 2 at the higher doses to 24.3/m 2 at the lower doses. In June 1976, five years after irradiation, there were 300 to 400 plants/m 2 . By extrapolating the plants/m 2 against dose back to zero plants/m 2 , some indication of radiation doses which might destroy all annuals was derived

  3. Multiple Bone Metastasis of Sclerosing Epithelioid Fibrosarcoma 12 Years after Initial Surgery—Increasing Ki-67 Labeling Index

    Directory of Open Access Journals (Sweden)

    Atsuko Kanno

    2009-01-01

    Full Text Available Sclerosing epithelioid fibrosarcoma (SEF is a rare sarcoma of low-grade malignancy. There has been no report to describe the comparison of histological features of SEF between primary and metastatic lesions in spite of high local recurrence rate. We report the histological changes and increasing Ki-67 labeling index of the primary and metastatic lesions of SEF. The patient was a 31-year-old man. At 18, a tumor in the abdominal wall was excised. At 23, the tumor recurred which was removed again. At 30, he was referred to our hospital because of swelling and pain in the chest. Histological examination of the chest wall tumor showed epithelioid cells arranged like alveolar pattern with dense collagen stroma. These findings were consistent with those of SEF. Abdominal and the rib tumors showed the same immunohistochemistrical expression. It is noteworthy that the tumor cells of the rib lesion showed increased cellularity, and its Ki-67 activity was higher as compared with the abdominal tumor, suggestive of progression of malignancy of SEF.

  4. Polarized electron sources

    Energy Technology Data Exchange (ETDEWEB)

    Prepost, R. [Univ. of Wisconsin, Madison, WI (United States)

    1994-12-01

    The fundamentals of polarized electron sources are described with particular application to the Stanford Linear Accelerator Center. The SLAC polarized electron source is based on the principle of polarized photoemission from Gallium Arsenide. Recent developments using epitaxially grown, strained Gallium Arsenide cathodes have made it possible to obtain electron polarization significantly in excess of the conventional 50% polarization limit. The basic principles for Gallium and Arsenide polarized photoemitters are reviewed, and the extension of the basic technique to strained cathode structures is described. Results from laboratory measurements of strained photocathodes as well as operational results from the SLAC polarized source are presented.

  5. A History of Ashes: An 80 Year Comparative Portrait of Smoking Initiation in American Indians and Non-Hispanic Whites—the Strong Heart Study

    Directory of Open Access Journals (Sweden)

    Jack Goldberg

    2013-05-01

    Full Text Available The consequences of starting smoking by age 18 are significant. Early smoking initiation is associated with higher tobacco dependence, increased difficulty in smoking cessation and more negative health outcomes. The purpose of this study is to examine how closely smoking initiation in a well-defined population of American Indians (AI resembles a group of Non-Hispanic white (NHW populations born over an 80 year period. We obtained data on age of smoking initiation among 7,073 AIs who were members of 13 tribes in Arizona, Oklahoma and North and South Dakota from the 1988 Strong Heart Study (SHS and the 2001 Strong Heart Family Study (SHFS and 19,747 NHW participants in the 2003 National Health Interview Survey. The participants were born as early as 1904 and as late as 1985. We classified participants according to birth cohort by decade, sex, and for AIs, according to location. We estimated the cumulative incidence of smoking initiation by age 18 in each sex and birth cohort group in both AIs and NHWs and used Cox regression to estimate hazard ratios for the association of birth cohort, sex and region with the age at smoking initiation. We found that the cumulative incidence of smoking initiation by age 18 was higher in males than females in all SHS regions and in NHWs (p < 0.001. Our results show regional variation of age of initiation significant in the SHS (p < 0.001. Our data showed that not all AIs (in this sample showed similar trends toward increased earlier smoking. For instance, Oklahoma SHS male participants born in the 1980s initiated smoking before age 18 less often than those born before 1920 by a ratio of 0.7. The results showed significant variation in age of initiation across sex, birth cohort, and location. Our preliminary analyses suggest that AI smoking trends are not uniform across region or gender but are likely shaped by local context. If tobacco prevention and control programs depend in part on addressing the origin of AI

  6. Association between Functional Capacity Decline and Nutritional Status Based on the Nutrition Screening Initiative Checklist: A 2-Year Cohort Study of Japanese Community-Dwelling Elderly.

    Science.gov (United States)

    Sugiura, Yumiko; Tanimoto, Yoshimi; Imbe, Ayumi; Inaba, Yuiko; Sakai, Satoshi; Shishikura, Kanako; Tanimoto, Keiji; Hanafusa, Toshiaki

    2016-01-01

    To assess whether nutritional status based on the Nutrition Screening Initiative Checklist is useful for predicting functional capacity decline in community-dwelling Japanese elderly. This two-year observational cohort study included 536 community-dwelling Japanese (65 years and older at baseline) who were independent in both activities and instrumental activities of daily living. Demographic attributes, chronic illness, lifestyle-related habits, nutritional status, functional capacity, and anthropometric measurements were assessed, with decline in functional capacity used as the outcome measure. Subjects were classified into three groups as follows based on the Nutrition Screening Initiative Checklist: low (59.5%), moderate (23.7%), and high (16.8%) nutritional risk. Significant differences were found between nutritional status and the following four baseline variables: age, hypertension, cerebrovascular diseases, and current smoking. However, no significant differences were evident between nutritional status and sex, body mass index, diabetes, drinking habit, or exercise habit. Logistic regression analysis adjusted for age, sex, body mass index, hypertension, cerebrovascular diseases and smoking habit showed that the high nutritional risk group was significantly associated with a decline in both activities of daily living (odds ratio: 4.96; 95% confidence interval (CI): 1.59-15.50) and instrumental activities of daily living (OR: 2.58; 95% CI: 1.31-5.06) compared with the low nutritional risk group. Poor nutritional status based on the Nutrition Screening Initiative Checklist was associated with a decline in functional capacity over a 2-year period in community-dwelling Japanese elderly. These results suggest that the Nutrition Screening Initiative Checklist is a suitable tool for predicting functional capacity decline in community-dwelling elderly.

  7. Polarized source performance in 1992 for SLC--SLD

    International Nuclear Information System (INIS)

    Schultz, D.; Alley, R.; Clendenin, J.; Frisch, J.; Garden, C.; Hoyt, E.; Klaisner, L.; Kulikov, A.; Prescott, C.; Saez, P.; Tang, H.; Turner, J.; Wicks, M.; Woods, M.; Yeremian, D.; Zolotorev, M.

    1993-02-01

    In its initial operation, the SLC Polarized Electron Source successfully met the SLC goals for 1992 for intensity and efficiency. However, the stability of the beam at the source was marginal, and the polarization was only ∼28%. The SLC goal to provide > 10,000 Z events for the SLD from polarized electrons was met

  8. One-year predictors of smoking initiation and of continued smoking among elementary schoolchildren in multiethnic, low-income, inner-city neighbourhoods.

    Science.gov (United States)

    O'Loughlin, J; Paradis, G; Renaud, L; Sanchez Gomez, L

    1998-01-01

    To identify one-year predictors of smoking initiation among never-smokers, and of continued smoking among ever-smokers. Two sequential cohorts of grade 4 and 5 children. Data were collected as part of Coeur en sante St Louis du Parc, a non-randomised controlled trial to evaluate the impact of a school-based heart health promotion programme. 24 inner-city elementary schools located in multiethnic, low-income neighbourhoods in Montreal. 1824 schoolchildren aged 9-12 years with baseline and one-year follow-up data. Changes in smoking behaviour over a year; the ability of baseline data to predict smoking initiation and continued smoking a year later was investigated in logistic regression analyses. The prevalence of ever-smoking was 21.1% at baseline and 30.2% at one-year follow up. One in six never-smokers initiated smoking; one in three ever-smokers continued smoking. Predictors of initiation included age (odds ratio (OR) = 1.6, 95% confidence interval (CI) = 1.3 to 2.0), male gender (OR = 1.5 (95% CI = 1.1 to 2.0)), friends who smoke (OR = 2.3 (95% CI = 1.7 to 3.3)), sibling(s) who smoke (OR = 1.9 (95% CI = 1.2 to 3.1)), father/mother who smokes (OR = 2.2 (95% CI = 1.6 to 3.0)), and frequent high fat/"junk food" consumption (OR = 1.6 (95% CI = 1.1 to 2.1)). Age and friends who smoke were also independent predictors of continued smoking in both genders. In addition, in boys, current smokers at baseline were 2.6 times (95% CI = 1.4 to 5.0) more likely to continue smoking than past smokers. In girls, being overweight was associated with continued smoking (OR = 3.5 (95% CI = 1.6 to 7.6)). Smoking prevention programmes should address parental and sibling influences on smoking, in addition to refusal skills training. Among girls, weight-related issues may also be important.

  9. Impact of structured programs on breastfeeding initiation rates in preterm neonates in a socioeconomically deprived area in France: A 10-year population-based study.

    Science.gov (United States)

    Charkaluk, M-L; Bomy, H; Delguste, S; Courdent, M; Rousseau, S; Zaoui-Grattepanche, C; Pierrat, V

    2018-01-01

    Structured programs have a positive impact on breastfeeding (BF) but have rarely been evaluated for preterm neonates, frequently combining prematurity and socioeconomic deprivation as risk factors of a low BF rate. We aimed to assess BF initiation rates in very preterm (preterm (33-36 weeks), and term neonates from 2002 to 2011 in a French administrative district characterized by socioeconomic deprivation. Structured activities to promote and support BF have been implemented in this area since 2002; they all started in neonatal units. This retrospective population-based study analyzed 302,102 first health certificates. Overall, the BF initiation rate significantly increased, from 52.9% [95% CI: (52.3; 53.4)] in 2002 to 61.0% [95% CI: (60.4; 61.6)] in 2011. In 2002, BF initiation rates did not differ between groups, but in 2011, it was higher for very preterm than for term and moderately preterm neonates [74.7% (69.7; 79.6)] vs. 60.9% (60.3; 61.5) and 59.9% (57.6; 62.2), respectively, both Ppreterm children and term-born children (P=0.40). The 2.2% yearly increase observed in very preterm neonates significantly differed from the 0.9% yearly increase in the French general population (Ppreterm neonates, but not in moderately preterm neonates, whose specific needs should be further evaluated. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  10. Polarized 3He gas circulating technologies for neutron analyzers

    Energy Technology Data Exchange (ETDEWEB)

    Watt, David W. [Xemed, LLC, Durham, NH (United States)

    2017-10-02

    apply sol-gel coatings to the interior of both borosilicate and aluminosilicate cells. We applied six sol-gel coatings. By modifying the mixture and developing procedures to drain and dry the cell, we produced visually uniform coatings on the interior of the cells. We now have perfected that process as described below in our report. We were able to accelerate the testing of cells using an ex situ method that avoids installing each cell into a polarizer. In the project’s last year, we conducted 38 external tests of 8 different cells. We also installed two sol-gel coated cells in our polarizers. We created cell with long ex situ relaxation lifetimes, one of which exceeded 40 hours. However, when installed in the polarizer the measured lifetime is 8 hours or less. 3. Demonstrated cycling of polarized gas and ex situ cell testing We are now cycling polarized gas from the polarizer to glass vessels and back. This has allowed us, for the first time, to make ex situ T1 measurements of polarizing cells without installing them into the polarizer itself. This has greatly improved our productivity in producing cells and evaluating our cell preparation processes. We continued development of the gas handling system in parallel with fabricating new polarizer. The integrated system was tested by the end of 2016. We now regularly cycle gas into and out of the polarizer. 4. Completed new polarizer infrastructure and control systems. We completed the new polarizer infrastructure in November 2016. The polarizer subsystems are 1) the frame, 2) the oil flow system, 3) the gas handling system, 4) the pressure vessel, with embedded solenoid, 5) cell mounting hardware with heat spreaders, and 6) electrical power and instrumentation. 5. Carried out initial tests of polarizer. We completed initial testing of the polarizer in April and May of 2017. These tests were carried out for periods up to 6 hours with laser power between 750 and 1300 Watts. The laser performed well and the polarization

  11. Experimental physics with polarized protons, neutrons and deuterons

    CERN Document Server

    Lehar, František; Wilkin, Colin

    2015-01-01

    The monograph gives a comprehensive overview of the diverse aspects of the experimental study of polarization phenomena in nucleon-nucleon and nucleon-deuteron collisions. The special nature of this volume is that it is based on the original physics results and knowledge gained by one of the authors (F. Lehar), who was a respected researcher in the field for nearly fifty years. The results of these experiments provide valuable information on the spin dependence of the forces acting between nucleons in atomic nuclei, of which all matter is ultimately composed. The fundamental importance of the results means that the subject will remain topical for years to come. The book is designed for teachers and students of natural sciences, espe - cially those with interests in nuclear and particle physics, as well as for ex - perimental physicists who are investigating polarization phenomena using accelerators of charged particles. The writing of the book was initiated by F. Lehar who was the driving force beh...

  12. Risk Score to Predict 1-Year Mortality after Haemodialysis Initiation in Patients with Stage 5 Chronic Kidney Disease under Predialysis Nephrology Care

    Science.gov (United States)

    Onishi, Yoshihiro

    2015-01-01

    Background Few risk scores are available for predicting mortality in chronic kidney disease (CKD) patients undergoing predialysis nephrology care. Here, we developed a risk score using predialysis nephrology practice data to predict 1-year mortality following the initiation of haemodialysis (HD) for CKD patients. Methods This was a multicenter cohort study involving CKD patients who started HD between April 2006 and March 2011 at 21 institutions with nephrology care services. Patients who had not received predialysis nephrology care at an estimated glomerular filtration rate (eGFR) of approximately 10 mL/min per 1.73 m2 were excluded. Twenty-nine candidate predictors were selected, and the final model for 1-year mortality was developed via multivariate logistic regression and was internally validated by a bootstrapping technique. Results A total of 688 patients were enrolled, and 62 (9.0%) patients died within one year of HD initiation. The following variables were retained in the final model: eGFR, serum albumin, calcium, Charlson Comorbidity Index excluding diabetes and renal disease (modified CCI), performance status (PS), and usage of erythropoiesis-stimulating agent (ESA). Their β-coefficients were transformed into integer scores: three points were assigned to modified CCI≥3 and PS 3–4; two to calcium>8.5 mg/dL, modified CCI 1–2, and no use of ESA; and one to albumin7 mL/min per 1.73 m2, and PS 1–2. Predicted 1-year mortality risk was 2.5% (score 0–4), 5.5% (score 5–6), 15.2% (score 7–8), and 28.9% (score 9–12). The area under the receiver operating characteristic curve was 0.83 (95% confidence interval, 0.79–0.89). Conclusions We developed a simple 6-item risk score predicting 1-year mortality after the initiation of HD that might help nephrologists make a shared decision with patients and families regarding the initiation of HD. PMID:26057129

  13. Epithelial cell polarity, stem cells and cancer

    DEFF Research Database (Denmark)

    Martin-Belmonte, Fernando; Perez-Moreno, Mirna

    2011-01-01

    After years of extensive scientific discovery much has been learned about the networks that regulate epithelial homeostasis. Loss of expression or functional activity of cell adhesion and cell polarity proteins (including the PAR, crumbs (CRB) and scribble (SCRIB) complexes) is intricately related......, deregulation of adhesion and polarity proteins can cause misoriented cell divisions and increased self-renewal of adult epithelial stem cells. In this Review, we highlight some advances in the understanding of how loss of epithelial cell polarity contributes to tumorigenesis....

  14. Past lessons and future importance of polarization

    International Nuclear Information System (INIS)

    Lipkin, H.J.

    1980-01-01

    Polarization and spin effects have traditionally brought surprises to physicists particularly to those who thought that such effects were unimportant. In hadron physics, large unexplained effects keep turning up and are still unresolved puzzles. A good measurement of the uninteresting beta ray polarization could have discovered parity nonconservation many years before its prediction by Lee and Yang. Nobody knows whether there are further exciting discoveries of this kind waiting for polarization experiments

  15. Growth and Mortality Outcomes for Different Antiretroviral Therapy Initiation Criteria in Children aged 1–5 Years: A Causal Modelling Analysis

    Science.gov (United States)

    Schomaker, Michael; Davies, Mary-Ann; Malateste, Karen; Renner, Lorna; Sawry, Shobna; N’Gbeche, Sylvie; Technau, Karl-Günter; Eboua, François; Tanser, Frank; Sygnaté-Sy, Haby; Phiri, Sam; Amorissani-Folquet, Madeleine; Cox, Vivian; Koueta, Fla; Chimbete, Cleophas; Lawson-Evi, Annette; Giddy, Janet; Amani-Bosse, Clarisse; Wood, Robin; Egger, Matthias; Leroy, Valeriane

    2017-01-01

    Background There is limited evidence regarding the optimal timing of initiating antiretroviral therapy (ART) in children. We conducted a causal modelling analysis in children aged 1–5 years from the International Epidemiologic Databases to Evaluate AIDS West/Southern-Africa collaboration to determine growth and mortality differences related to different CD4-based treatment initiation criteria, age groups and regions. Methods ART-naïve children of age 12–59 months at enrollment with at least one visit before ART initiation and one follow-up visit were included. We estimated 3-year growth and cumulative mortality from the start of follow-up for different CD4 criteria using g-computation. Results About one quarter of the 5826 included children was from West Africa (24.6%). The median (first; third quartile) CD4% at the first visit was 16% (11%;23%), the median weight-for-age z-scores and height-for-age z-scores were −1.5 (−2.7; −0.6) and −2.5 (−3.5; −1.5), respectively. Estimated cumulative mortality was higher overall, and growth was slower, when initiating ART at lower CD4 thresholds. After 3 years of follow-up, the estimated mortality difference between starting ART routinely irrespective of CD4 count and starting ART if either CD4 count<750 cells/mm3 or CD4%<25% was 0.2% (95%CI: −0.2%;0.3%), and the difference in the mean height-for-age z-scores of those who survived was −0.02 (95%CI: −0.04;0.01). Younger children aged 1–2 and children in West Africa had worse outcomes. Conclusions Our results demonstrate that earlier treatment initiation yields overall better growth and mortality outcomes, though we could not show any differences in outcomes between immediate ART and delaying until CD4 count/% falls below750/25%. PMID:26479876

  16. Feasibility studies of a polarized positron source based on the Bremsstrahlung of polarized electrons

    International Nuclear Information System (INIS)

    Dumas, J.

    2011-09-01

    The nuclear and high-energy physics communities have shown a growing interest in the availability of high current, highly-polarized positron beams. A sufficiently energetic polarized photon or lepton incident on a target may generate, via Bremsstrahlung and pair creation within a solid target foil, electron-positron pairs that should carry some fraction of the initial polarization. Recent advances in high current (> 1 mA) spin polarized electron sources at Jefferson Lab offer the perspective of creating polarized positrons from a low energy electron beam. This thesis discusses polarization transfer from electrons to positrons in the perspective of the design optimization of a polarized positron source. The PEPPo experiment, aiming at a measurement of the positron polarization from a low energy (< 10 MeV) highly spin polarized electron beam is discussed. A successful demonstration of this technique would provide an alternative scheme for the production of low energy polarized positrons and useful information for the optimization of the design of polarized positron sources in the sub-GeV energy range. (author)

  17. Negative predictive value of multiparametric MRI for prostate cancer detection: Outcome of 5-year follow-up in men with negative findings on initial MRI studies

    Energy Technology Data Exchange (ETDEWEB)

    Itatani, R., E-mail: banguliao@gmail.com [Department of Diagnostic Radiology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1, Honjo, Kumamoto 860-8556 (Japan); Department of Radiology, Kumamoto Chuo Hospital, 1-5-1, Tainoshima, Kumamoto 862-0965 (Japan); Namimoto, T. [Department of Diagnostic Radiology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1, Honjo, Kumamoto 860-8556 (Japan); Atsuji, S.; Katahira, K.; Morishita, S. [Department of Radiology, Kumamoto Chuo Hospital, 1-5-1, Tainoshima, Kumamoto 862-0965 (Japan); Kitani, K.; Hamada, Y. [Department of Urology, Kumamoto Chuo Hospital, 1-5-1, Tainoshima, Kumamoto 862-0965 (Japan); Kitaoka, M. [Department of Pathology, Kumamoto Chuo Hospital, 1-5-1, Tainoshima, Kumamoto 862-0965 (Japan); Nakaura, T. [Department of Diagnostic Radiology, Amakusa Medical Center, Kameba 854-1, Amakusa, Kumamoto 863-0046 (Japan); Yamashita, Y. [Department of Diagnostic Radiology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1, Honjo, Kumamoto 860-8556 (Japan)

    2014-10-15

    Highlights: • We assess the negative predictive value of multiparametric MRI for prostate cancer. • Patients with positive prostate biopsy findings were defined as false-negative. • Patients with negative initial prostate biopsy findings were followed up for 5 years. • The negative predictive value was 89.6% for significant prostate cancer. • MRI is a useful tool to rule out significant prostate cancer before biopsy. - Abstract: Objective: To assess the clinical negative predictive value (NPV) of multiparametric MRI (mp-MRI) for prostate cancer in a 5-year follow-up. Materials and methods: One hundred ninety-three men suspected of harboring prostate cancer with negative MRI findings were included. Patients with positive transrectal ultrasound (TRUS)-guided biopsy findings were defined as false-negative. Patients with negative initial TRUS-guided biopsy findings were followed up and only patients with negative findings by digital rectal examination, MRI, and repeat biopsy and no increase in PSA at 5-year follow-up were defined as “clinically negative”. The clinical NPV of mp-MRI was calculated. For quantitative analysis, mean signal intensity on T2-weighted images and the mean apparent diffusion coefficient value on ADC maps of the initial MRI studies were compared between peripheral-zone (PZ) cancer and the normal PZ based on pathologic maps of patients who had undergone radical prostatectomy. Results: The clinical NPV of mp-MRI was 89.6% for significant prostate cancer. Small cancers, prostatitis, and benign prostatic hypertrophy masking prostate cancer returned false-negative results. Quantitative analysis showed that there was no significant difference between PZ cancer and the normal PZ. Conclusion: The mp-MRI revealed a high clinical NPV and is a useful tool to rule out clinically significant prostate cancer before biopsy.

  18. Geographical Income Polarization

    DEFF Research Database (Denmark)

    Azhar, Hussain; Jonassen, Anders Bruun

    inter municipal income inequality. Counter factual simulations show that rising property prices to a large part explain the rise in polarization. One side-effect of polarization is tendencies towards a parallel polarization of residence location patterns, where low skilled individuals tend to live......In this paper we estimate the degree, composition and development of geographical income polarization based on data at the individual and municipal level in Denmark from 1984 to 2002. Rising income polarization is reconfirmed when applying new polarization measures, the driving force being greater...

  19. Progression of MDS-UPDRS Scores Over Five Years in De Novo Parkinson Disease from the Parkinson's Progression Markers Initiative Cohort.

    Science.gov (United States)

    Holden, Samantha K; Finseth, Taylor; Sillau, Stefan H; Berman, Brian D

    2018-01-01

    The Movement Disorder Society Unified Parkinson Disease Rating Scale (MDS-UDPRS) is a commonly used tool to measure Parkinson disease (PD) progression. Longitudinal changes in MDS-UPDRS scores in de novo PD have not been established. Determine progression rates of MDS-UPDRS scores in de novo PD. 362 participants from the Parkinson's Progression Markers Initiative, a multicenter longitudinal cohort study of de novo PD, were included. Longitudinal progression of MDS-UPDRS total and subscale scores were modeled using mixed model regression. MDS-UPDRS scores increased in a linear fashion over five years in de novo PD. MDS-UPDRS total score increased an estimated 4.0 points/year, Part I 0.25 points/year, Part II 1.0 points/year, and Part III 2.4 points/year. The expected average progression of MDS-UPDRS scores in de novo PD from this study can assist in clinical monitoring and provide comparative data for detection of disease modification in treatment trials.

  20. NOAA's Joint Polar Satellite System's Proving Ground and Risk Reduction Program - Bringing New Capabilities to Operations!

    Science.gov (United States)

    Sjoberg, B.

    2015-12-01

    This presentation will focus on the NOAA Joint Polar Satellite System (JPSS) Program's Proving Ground and Risk Reduction (PGRR) initiative and how it has prepared NOAA users to effectively utilize new polar-orbiting capabilities. The PGRR Program was established in 2012, following the launch of the Suomi National Polar Partnership (SNPP) satellite. Two sets of PGRR Projects have been established grouped together in thirteen different initiatives. Details about how these projects have been continually tailored through the years to meet user requirements, will be highlighted. The presenter will focus on how the success of the first set of PGRR projects have been used to evaluate a follow-on set of projects and focus on exactly what the JPSS user community needs to meet their mission requirements. Details on the Dec 2014 PGRR Call-for-Proposals and the projects selected for funding will be discussed.

  1. Decreasing Disability Processing Days for Soldiers in the U.S. Army Through Initiatives in Human Resource Management Support Systems: A Two-Tiered, Three Year Evaluation

    Directory of Open Access Journals (Sweden)

    Bernard Kerr, Jr.

    2005-02-01

    Full Text Available This essay highlights the findings of a two tiered, three year evaluation. The first tier studied human resource and quality management initiatives at Walter Reed Army Medical Center (WRAMC Washington, DC from 1992-1994. The second tier researched disability records through the United States Army Physical Disability Agency, Bethesda, Maryland in 1996. The first tier found that Total Quality Management reduced the average length of stay (ALOS and size of the disability population from 220 days and 240 disability cases to 65 days and 57 disability cases over 24 months. The second tier studied 8,301 soldiers whose disability records were processed in Fiscal Year 1996. The research shows only administrative variables affect ALOS. The authors recommend a program of disability case management and increasing emphasis on transition assistance programs to reduce ALOS in the PDES.

  2. RHIC Polarized proton performance in run-8

    Energy Technology Data Exchange (ETDEWEB)

    Montag,C.; Bai, M.; MacKay, W.W.; Roser, T.; Abreu, N.; Ahrens, L.; Barton, D.; Beebe-Wang, J.; Blaskiewicz, M.; Brennan, J.M.; Brown, K.A.; Bruno, D.; Bunce, G.; Calaga, R.; Cameron, P.; Connolly, R.; D' Ottavio, T.; Drees, A.; Fedotov, A.V.; Fischer, W.; Ganetis, G.; Gardner, C.; Glenn, J.; Hayes, T.; Huang, H.; Ingrassia, P.; Kayran, D.A.; Kewisch, J.; Lee, R.C.; Lin, F.; Litvinenko, V.N.; Luccio, A.U.; Luo, Y.; Makdisi, Y.; Malitsky, N.; Marr, G.; Marusic, A.; Michnoff, R.; Morris, J.; Oerter, B.; Pilat, F.; Pile, P.; Robert-Demolaize, G.; Russo, T.; Satogata, T.; Schultheiss, C.; Sivertz, M.; Smith, K.; Tepikian, S.; D. Trbojevic, D.; Tsoupas, N.; Tuozzolo, J.; Zaltsman, A.; Zelenski, A.; Zeno, K.; Zhang, S.Y.

    2008-10-06

    During Run-8, the Relativistic Heavy Ion Collider (RHIC) provided collisions of spin-polarized proton beams at two interaction regions. Physics data were taken with vertical orientation of the beam polarization, which in the 'Yellow' RHIC ring was significantly lower than in previous years. We present recent developments and improvements as well as the luminosity and polarization performance achieved during Run-8, and we discuss possible causes of the not as high as previously achieved polarization performance of the 'Yellow' ring.

  3. Polarized Light Corridor Demonstrations.

    Science.gov (United States)

    Davies, G. R.

    1990-01-01

    Eleven demonstrations of light polarization are presented. Each includes a brief description of the apparatus and the effect demonstrated. Illustrated are strain patterns, reflection, scattering, the Faraday Effect, interference, double refraction, the polarizing microscope, and optical activity. (CW)

  4. Negative predictive value of multiparametric MRI for prostate cancer detection: outcome of 5-year follow-up in men with negative findings on initial MRI studies.

    Science.gov (United States)

    Itatani, R; Namimoto, T; Atsuji, S; Katahira, K; Morishita, S; Kitani, K; Hamada, Y; Kitaoka, M; Nakaura, T; Yamashita, Y

    2014-10-01

    To assess the clinical negative predictive value (NPV) of multiparametric MRI (mp-MRI) for prostate cancer in a 5-year follow-up. One hundred ninety-three men suspected of harboring prostate cancer with negative MRI findings were included. Patients with positive transrectal ultrasound (TRUS)-guided biopsy findings were defined as false-negative. Patients with negative initial TRUS-guided biopsy findings were followed up and only patients with negative findings by digital rectal examination, MRI, and repeat biopsy and no increase in PSA at 5-year follow-up were defined as "clinically negative". The clinical NPV of mp-MRI was calculated. For quantitative analysis, mean signal intensity on T2-weighted images and the mean apparent diffusion coefficient value on ADC maps of the initial MRI studies were compared between peripheral-zone (PZ) cancer and the normal PZ based on pathologic maps of patients who had undergone radical prostatectomy. The clinical NPV of mp-MRI was 89.6% for significant prostate cancer. Small cancers, prostatitis, and benign prostatic hypertrophy masking prostate cancer returned false-negative results. Quantitative analysis showed that there was no significant difference between PZ cancer and the normal PZ. The mp-MRI revealed a high clinical NPV and is a useful tool to rule out clinically significant prostate cancer before biopsy. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  5. Transcatheter closure of perimembranous ventricular septal defect with the Amplatzer(®) membranous VSD occluder 2: initial world experience and one-year follow-up.

    Science.gov (United States)

    Tzikas, Apostolos; Ibrahim, Reda; Velasco-Sanchez, Daniel; Freixa, Xavier; Alburquenque, Marcela; Khairy, Paul; Bass, John L; Ramirez, Juan; Aguirre, Daniel; Miro, Joaquim

    2014-03-01

    To describe the initial world experience and mid-term follow-up of perimembranous ventricular septal defect (pmVSD) closure with a newly designed occluder. Transcatheter closure of pmVSDs has been associated with a substantial risk of complete heart block, prompting many centers to abandon this intervention. A prospective multicenter cohort study was conducted on patients with pmVSD undergoing catheter closure using the Amplatzer(®) Membranous VSD Occluder 2 in the initial 4 pilot centers. Nineteen patients, median age 6 years (range 1.4-62 years), were enrolled and followed for 14 ± 3 months (range 8-20 months). The median weight was 26 kg (range 9.3-96 kg) and the mean Qp/Qs ratio was 1.8 ± 0.7. The defect on left ventricular side measured 9.9 ± 3.5 mm and the orifice on right ventricular side was 8.1 ± 2.8 mm by echocardiography. Mean device size was 9.4 ± 2.4 mm (range 5-14 mm). An eccentric device was employed in 9 patients (47%) and a concentric device in 10 (53%). Overall, 18 patients (95%) had successful device implants. Procedural time was 122 ± 39 min. There were no procedural complications. Mild residual shunting was initially observed in 14 (78%) patients. At last follow-up, mild residual shunting persisted in only 3 (17%) patients. There was no significant increase in aortic or tricuspid regurgitation. No patient had any degree of AV block, although one developed a transient left anterior fascicular block. Holter evaluation, obtained in all patients, was unremarkable in all. This early cohort experience using a novel adapted transcatheter closure device for pmVSD suggests that the procedure is feasible, safe, and effective. Copyright © 2013 Wiley Periodicals, Inc.

  6. Polar and Alpine Microbiology - Earth's Cryobiosphere

    Czech Academy of Sciences Publication Activity Database

    Elster, Josef; Margesin, R.; Wagner, D.; Häggblom, M.

    2017-01-01

    Roč. 93, č. 1 (2017), s. 1-4, č. článku fiw221. ISSN 0168-6496 Institutional support: RVO:67985939 Keywords : diversity * Polar regions * Polar Microbiology Subject RIV: EH - Ecology, Behaviour OBOR OECD: Ecology Impact factor: 3.720, year: 2016

  7. On the identification of magnetostratigraphic polarity zones

    Czech Academy of Sciences Publication Activity Database

    Man, Otakar

    2008-01-01

    Roč. 52, č. 2 (2008), s. 173-186 ISSN 0039-3169 R&D Projects: GA ČR GA205/07/1365 Institutional research plan: CEZ:AV0Z30130516 Keywords : paleomagnetism * geomagnetic polarity reversals * magnetic polarity stratigraphy Subject RIV: DE - Earth Magnetism, Geodesy, Geography Impact factor: 0.770, year: 2008

  8. Optical pumping production of spin polarized hydrogen

    International Nuclear Information System (INIS)

    Knize, R.J.; Happer, W.; Cecchi, J.L.

    1984-01-01

    There has been much interest recently in the production of large quantities of spin polarized hydrogen in various fields including controlled fusion, quantum fluids, high energy, and nuclear physics. One promising method for the development of large quantities of spin polarized hydrogen is the utilization of optical pumping with a laser. Optical pumping is a process where photon angular momentum is converted into electron and nuclear spin. The advent of tunable CW dye lasers (approx. 1 watt) allow the production of greater than 10 18 polarized atoms/sec. We have begun a program at Princeton to investigate the physics and technology of using optical pumping to produce large quantities of spin polarized hydrogen. Initial experiments have been done in small closed glass cells. Eventually, a flowing system, open target, or polarized ion source could be constructed

  9. Polarized Moessbauer transitions

    International Nuclear Information System (INIS)

    Barb, D.

    1975-01-01

    Theoretical aspects of the emission, absorption and scattering of polarized gamma rays are reviewed for a general case of combined magnetic and electric hyperfine interactions; various possibilities of obtaining polarized gamma sources are described and examples are given of the applications of Moessbauer spectroscopy with polarized gamma rays in solving problems of solid state physics. (A.K.)

  10. Antiretroviral regimen durability and success in treatment-naïve and treatment-experienced patients by year of treatment initiation, United States, 1996–2011

    Science.gov (United States)

    Sheth, Anandi N.; Ofotokun, Ighovwerha; Buchacz, Kate; Armon, Carl; Chmiel, Joan S.; Hart, Rachel L.D.; Baker, Rose; Brooks, John T.; Palella, Frank J.

    2015-01-01

    Background Although modern combination antiretroviral therapy (cART) regimens are better tolerated and less complex than earlier treatments, regimen modification or discontinuation remains a concern. Methods We studied HIV Outpatient Study (HOPS) participants who initiated first or second cART regimens during: 1996–1999, 2000–2003, 2004–2007 and 2008–2011. We analyzed regimen durability (time to regimen modification) and success (achieving undetectable plasma HIV RNA) for first and second cART regimens using Kaplan-Meier curves and log-rank tests, and examined factors associated with durability and success of first cART regimen using proportional hazards models. Results Durability of cART was progressively longer for cART regimens initiated in more recent periods: median first cART regimen durations were 1.0, 1.1, 2.1 and 4.6 years in 1996–1999, 2000–2003, 2004–2007 and 2008–2011, and median second cART durations were 0.9, 1.2, 2.8 and 3.9 years, respectively (both p<0.001). Comparing 1996–1999 and 2008–2011, the percentage of patients who achieved an undetectable HIV RNA within 6 months of first cART initiation increased from 65% to 81%, and from 63% to 80% on second cART (both p<0.001). Among patients initiating first cART during 2008–2011, black non-Hispanic/Latino race/ethnicity and ≥twice daily dosing were significantly associated with higher rates of regimen modification (p<0.05), and higher baseline HIV RNA levels were associated with failure to achieve an undetectable HIV RNA (p<0.001). Conclusions Among HIV-infected U.S. adults in routine HIV care, durability of first and second cART regimens and the likelihood of prompt virologic suppression increased during 1996–2011, coincident with the availability of more tolerable, less complex cART options. PMID:26334737

  11. The Physics of Polarization

    Science.gov (United States)

    Landi Degl'Innocenti, Egidio

    2015-10-01

    The introductory lecture that has been delivered at this Symposium is a condensed version of an extended course held by the author at the XII Canary Island Winter School from November 13 to November 21, 2000. The full series of lectures can be found in Landi Degl'Innocenti (2002). The original reference is organized in 20 Sections that are here itemized: 1. Introduction, 2. Description of polarized radiation, 3. Polarization and optical devices: Jones calculus and Muller matrices, 4. The Fresnel equations, 5. Dichroism and anomalous dispersion, 6. Polarization in everyday life, 7. Polarization due to radiating charges, 8. The linear antenna, 9. Thomson scattering, 10. Rayleigh scattering, 11. A digression on Mie scattering, 12. Bremsstrahlung radiation, 13. Cyclotron radiation, 14. Synchrotron radiation, 15. Polarization in spectral lines, 16. Density matrix and atomic polarization, 17. Radiative transfer and statistical equilibrium equations, 18. The amplification condition in polarized radiative transfer, and 19. Coupling radiative transfer and statistical equilibrium equations.

  12. Anthropometric parameters for the female handball talents gaining from “Ormani Arenado Llonch” Initial Sport School of 15-18 years senior category

    Directory of Open Access Journals (Sweden)

    Luis Alberto Hernández-Pérez

    2014-08-01

    Full Text Available This work approaches an important and present time problem for the staff that is working directly with handball sport training, because it treats aspects that are kept in the talents selection having as general objective to propose anthropometric parameters to attract female handball talentns from “Ormani Arenado Llonch” Initial Sport School of 15-18 years senior category. It was carried out a wide and detailed bibliographical revision about the topic, as well as interviews addressed to specialists that are part of the team management system with the objective of proposing anthropometric parameters for the gainig, allowing to determine the current necessities of this pedagogic process, as well as to establish these parameters to facilitate this process and making it more effective.

  13. ParticipACTION after 5 years of relaunch: a quantitative survey of Canadian organizational awareness and capacity regarding physical activity initiatives

    Directory of Open Access Journals (Sweden)

    Guy Faulkner

    2018-04-01

    Full Text Available Introduction: ParticipACTION is a Canadian physical activity communications and social marketing organization relaunched in 2007. This study assesses the capacity of Canadian organizations to adopt, implement, and promote physical activity initiatives. The four objectives were to compare findings from baseline (2008 and follow-up (2013 with respect to: (1 awareness of ParticipACTION; (2 organizational capacity to adopt, implement and promote physical activity initiatives; (3 potential differences in capacity based on organizational size, sector, and mandate; and (4 assess perceptions of ParticipACTION five years after relaunch. Methods: In this cross-sectional study, representatives from local, provincial/territorial, and national organizations completed an online survey assessing capacity to adopt, implement, and promote physical activity. Descriptive statistics and one-way analyses of variance were conducted to examine the objectives. Results: Response rate for opening an email survey invitation and consenting to participate was 40.6% (685/1688 and 540 surveys were completed. Awareness of ParticipACTION increased from 54.6% at baseline to 93.9% at follow-up (Objective 1. Findings at both baseline and follow-up reflected good organizational capacity to adopt, implement and promote physical activity (Objective 2 although some varied by organizational sector and mandate (Objective 3. Most respondents reported that ParticipACTION provided positive leadership (65.3%, but there was less agreement regarding ParticipACTION’s facilitation of infrastructure (44.0% or organizational will/motivation (47.1%(Objective 4. Conclusion: Canadian organizations continue to report having good capacity to adopt, implement, and promote physical activity. There was no discernible change in capacity indicators five years after ParticipACTION’s relaunch although its broader contribution to the physical activity sector was endorsed.

  14. Screening in asymptomatic SDHx mutation carriers: added value of 18F-FDG PET/CT at initial diagnosis and 1-year follow-up

    International Nuclear Information System (INIS)

    Lepoutre-Lussey, C.; Deandreis, D.; Berdelou, A.; Nascimento, C.; Lumbroso, J.; Schlumberger, M.; Baudin, E.; Leboulleux, S.; Caramella, C.; Bidault, F.; Deschamps, F.; Al Ghuzlan, A.; Hartl, D.; Dumont, F.; Borget, I.; Gimenez-Roqueplo, A.P.; Guillaud Bataille, M.

    2015-01-01

    Specific recommendations on screening modalities for paraganglioma (PGL) and phaeochromocytoma (PCC) in asymptomatic SDHx mutation carriers (relatives) are still lacking. We evaluated the added value of 18 F-FDG PET/CT in comparison with morphological imaging at initial diagnosis and 1 year of follow-up in this population. The study included 30 consecutive relatives with a proven SDHx mutation who were investigated by 18 F-FDG PET/CT, gadolinium-enhanced magnetic resonance angiography of the head and neck, thoracic/abdominal/pelvic (TAP) contrast-enhanced CT and/or TAP MRI. 123 I-MIBG scintigraphy was performed in 20 subjects and somatostatin receptor scintigraphy (SRS) in 20 subjects. The gold standard was based on pathology or a composite endpoint as defined by any other positive imaging method and persistent tumour on follow-up. Images were considered as false-positive when the lesions were not detected by another imaging method or not confirmed at 1 year. At initial work-up, an imaging abnormality was found in eight subjects (27 %). The final diagnosis was true-positive in five subjects (two with abdominal PGL, one with PCC and two with neck PGL) and false-positives in the other three subjects (detected with 18 F-FDG PET/CT in two and TAP MRI in one). At 1 year, an imaging abnormality was found in three subjects of which one was an 8-mm carotid body PGL in a patient with SDHD mutation and two were considered false-positive. The tumour detection rate was 100 % for 18 F-FDG PET/CT and conventional imaging, 80 % for SRS and 60 % for 123 I-MIBG scintigraphy. Overall, disease was detected in 4 % of the subjects at the 1-year follow-up. 18 F-FDG PET/CT demonstrated excellent sensitivity but intermediate specificity justifying combined modality imaging in these patients. Given the slow progression of the disease, if 18 F-FDG PET/CT and MRI are normal at baseline, the second imaging work-up should be delayed and an examination that does not expose the patient to

  15. Screening in asymptomatic SDHx mutation carriers: added value of {sup 18}F-FDG PET/CT at initial diagnosis and 1-year follow-up

    Energy Technology Data Exchange (ETDEWEB)

    Lepoutre-Lussey, C.; Deandreis, D.; Berdelou, A.; Nascimento, C.; Lumbroso, J.; Schlumberger, M.; Baudin, E.; Leboulleux, S. [Gustave Roussy Institut, Universite Paris-Sud, Department of Nuclear Medicine and Endocrine Oncology, Villejuif (France); Caramella, C.; Bidault, F.; Deschamps, F. [Gustave Roussy Institut, Department of Radiology, Villejuif (France); Al Ghuzlan, A. [Gustave Roussy Institut, Department of Medical Biology and Pathology, Villejuif (France); Hartl, D.; Dumont, F. [Gustave Roussy Institut, Department of Surgery, Villejuif (France); Borget, I. [Gustave Roussy Institut, Department of Biostatistic and Epidemiology, Villejuif (France); Paris-Sud University, Villejuif (France); Gimenez-Roqueplo, A.P. [Assistance Publique-Hopitaux de Paris, Hopital Europeen Georges Pompidou, Department of Genetics, Paris (France); Paris Descartes University, Faculty of Medicine, Paris (France); Guillaud Bataille, M. [Gustave Roussy Institut, Department of Genetics, Villejuif (France)

    2015-05-01

    Specific recommendations on screening modalities for paraganglioma (PGL) and phaeochromocytoma (PCC) in asymptomatic SDHx mutation carriers (relatives) are still lacking. We evaluated the added value of {sup 18}F-FDG PET/CT in comparison with morphological imaging at initial diagnosis and 1 year of follow-up in this population. The study included 30 consecutive relatives with a proven SDHx mutation who were investigated by {sup 18}F-FDG PET/CT, gadolinium-enhanced magnetic resonance angiography of the head and neck, thoracic/abdominal/pelvic (TAP) contrast-enhanced CT and/or TAP MRI. {sup 123}I-MIBG scintigraphy was performed in 20 subjects and somatostatin receptor scintigraphy (SRS) in 20 subjects. The gold standard was based on pathology or a composite endpoint as defined by any other positive imaging method and persistent tumour on follow-up. Images were considered as false-positive when the lesions were not detected by another imaging method or not confirmed at 1 year. At initial work-up, an imaging abnormality was found in eight subjects (27 %). The final diagnosis was true-positive in five subjects (two with abdominal PGL, one with PCC and two with neck PGL) and false-positives in the other three subjects (detected with {sup 18}F-FDG PET/CT in two and TAP MRI in one). At 1 year, an imaging abnormality was found in three subjects of which one was an 8-mm carotid body PGL in a patient with SDHD mutation and two were considered false-positive. The tumour detection rate was 100 % for {sup 18}F-FDG PET/CT and conventional imaging, 80 % for SRS and 60 % for {sup 123}I-MIBG scintigraphy. Overall, disease was detected in 4 % of the subjects at the 1-year follow-up. {sup 18}F-FDG PET/CT demonstrated excellent sensitivity but intermediate specificity justifying combined modality imaging in these patients. Given the slow progression of the disease, if {sup 18}F-FDG PET/CT and MRI are normal at baseline, the second imaging work-up should be delayed and an examination

  16. Prevalence and geographic variation of abdominal obesity in 7- and 9-year-old children in Greece; World Health Organization Childhood Obesity Surveillance Initiative 2010.

    Science.gov (United States)

    Hassapidou, Maria; Tzotzas, Themistoklis; Makri, Evangelia; Pagkalos, Ioannis; Kaklamanos, Ioannis; Kapantais, Efthymios; Abrahamian, Annet; Polymeris, Antonis; Tziomalos, Konstantinos

    2017-01-28

    In children, abdominal obesity is a better predictor of the presence of cardiovascular risk factors than body mass index (BMI)-defined obesity. We aimed to evaluate the prevalence of abdominal obesity in the Greek pediatric population and to assess the impact of residence on the prevalence of both BMI-defined and abdominal obesity. In the context of the Childhood Obesity Surveillance Initiative of the World Health Organization (WHO) Regional Office for Europe, a national representative sample of 7.0-7.9 and 9.0-9.9-year-old children was evaluated (n = 2,531 and 2,700, respectively). Overweight and obesity according to BMI were estimated using both the WHO and International Obesity Task Force cut-off points. Abdominal obesity was defined as waist circumference/height ratio >0.5. The prevalence of abdominal obesity did not differ between 7-year-old boys and girls (25.2 and 25.3%, respectively; p = NS). Among 9-year-old children, abdominal obesity was more prevalent in boys than in girls (33.2 and 28.2%, respectively; p = 0.005). Among normal weight and overweight children, the prevalence of abdominal obesity was 1.6-6.8 and 21.8-49.1%, respectively. The prevalence of abdominal and BMI-defined obesity did not differ between children living in the mainland, in Crete and in other islands except in 7-year-old girls, where the prevalence of BMI-defined obesity was highest in those living in Crete, intermediate in those living in other islands and lowest in those living in the mainland. In 9-year-old boys and in 7- and 9-year-old girls, the prevalence of abdominal obesity was highest in children living in Athens and lowest in children living in Thessaloniki, whereas children living in other cities and in villages showed intermediate rates. The prevalence of abdominal obesity in 7-year-old boys and the prevalence of BMI-defined obesity did not differ between children living in cities and villages. The prevalence of pediatric abdominal obesity in Greece is among

  17. Prevalence and geographic variation of abdominal obesity in 7- and 9-year-old children in Greece; World Health Organization Childhood Obesity Surveillance Initiative 2010

    Directory of Open Access Journals (Sweden)

    Maria Hassapidou

    2017-01-01

    Full Text Available Abstract Background In children, abdominal obesity is a better predictor of the presence of cardiovascular risk factors than body mass index (BMI-defined obesity. We aimed to evaluate the prevalence of abdominal obesity in the Greek pediatric population and to assess the impact of residence on the prevalence of both BMI-defined and abdominal obesity. Methods In the context of the Childhood Obesity Surveillance Initiative of the World Health Organization (WHO Regional Office for Europe, a national representative sample of 7.0–7.9 and 9.0–9.9-year-old children was evaluated (n = 2,531 and 2,700, respectively. Overweight and obesity according to BMI were estimated using both the WHO and International Obesity Task Force cut-off points. Abdominal obesity was defined as waist circumference/height ratio >0.5. Results The prevalence of abdominal obesity did not differ between 7-year-old boys and girls (25.2 and 25.3%, respectively; p = NS. Among 9-year-old children, abdominal obesity was more prevalent in boys than in girls (33.2 and 28.2%, respectively; p = 0.005. Among normal weight and overweight children, the prevalence of abdominal obesity was 1.6–6.8 and 21.8–49.1%, respectively. The prevalence of abdominal and BMI-defined obesity did not differ between children living in the mainland, in Crete and in other islands except in 7-year-old girls, where the prevalence of BMI-defined obesity was highest in those living in Crete, intermediate in those living in other islands and lowest in those living in the mainland. In 9-year-old boys and in 7- and 9-year-old girls, the prevalence of abdominal obesity was highest in children living in Athens and lowest in children living in Thessaloniki, whereas children living in other cities and in villages showed intermediate rates. The prevalence of abdominal obesity in 7-year-old boys and the prevalence of BMI-defined obesity did not differ between children living in cities and villages

  18. WHO European Childhood Obesity Surveillance Initiative in Serbia: a prevalence of overweight and obesity among 6-9-year-old school children.

    Science.gov (United States)

    Djordjic, Visnja; Radisavljevic, Snezana; Milanovic, Ivana; Bozic, Predrag; Grbic, Miljana; Jorga, Jagoda; Ostojic, Sergej M

    2016-09-01

    The World Health Organization (WHO) European Childhood Obesity Surveillance Initiative (COSI) is a public health program established in order to understand the progress of the obesity epidemic in young populations and gain inter-country comparisons within the European region, yet the data from a number of East European countries, including Serbia, were not available then. Therefore, the main aim of this cross-sectional study was to collect data about the prevalence of overweight and obesity among 6-9-year-old school children in Serbia according to the standardized protocol during the Fourth COSI Implementation Round. From September 2015 to November 2015, 5102 first- and second-grade primary-school children (age 7.7±0.6 years) were assessed for weight, height, and body mass index (BMI) in 14 Serbian school districts. The prevalence rates of obesity, as calculated using the International Obesity Task Force (IOTF) cut-off points, vary across different age groups, with the lowest obesity rates reported in 7-year-old boys (6.2%), while the highest obesity prevalence rates were observed in 6-year-old boys (9.7%). In addition, being overweight was strongly associated with poor local community development and lower level of urbanization. The overall prevalence of overweight (23.1%, including obesity) and obesity (6.9%) in Serbian primary-school children seem to be comparable to rather high rates previously reported in other countries participating in the COSI program, indicating an obesity epidemic in Serbian children. This surveillance system should be regularly implemented throughout Europe, providing comparable data on rates of overweight/obesity in primary schools that might drive prudent actions to reverse the pandemic trend of childhood obesity.

  19. On the polarization of fermion in an intermediate state

    Science.gov (United States)

    Kaloshin, A. E.; Lomov, V. P.

    2017-06-01

    We show that calculation of a final fermion polarization (for a pure initial state) is equivalent to the problem of looking for complete polarization axis of bispinor. This gives the method for calculation of polarization applicable both for final and intermediate state fermions. We suggest to use fermion propagator (bare or dressed) in form of spectral representation, which gives the orthogonal off-shell energy projectors. This representation leads to covariant separation of particle and antiparticle contributions and gives a natural definition for polarization of intermediate state fermion. The most evident application is related with consistent description of t-quark polarization.

  20. How campaigns polarize the electorate

    DEFF Research Database (Denmark)

    Hansen, Kasper Møller; Kosiara-Pedersen, Karina

    2015-01-01

    The minimal effect theory of campaign studies stipulates that intense political competition during campaigns assures and reinforces the initial party choice of the electorate. We find that this reinforcement is two-fold. During the campaign, the party preference of the voters’ in-group party...... an increase in their preference for their most preferred party and a decrease for their least liked party as the campaign progresses. These trends show that the political campaign polarizes the electorate by increasing the affective distance between in-group party and out-group party preferences, thereby...... resulting in stronger political polarization after the campaign than before the campaign. The data utilized in this study is a large six-wave panel-study of Danish voters’ party preferences during the Danish parliamentary election of 2011. Thus, the analysis provides evidence of the minimal effect theory...

  1. The accomplishments of the global initiative VISION 2020: The Right to Sight and the focus for the next 8 years of the campaign

    Directory of Open Access Journals (Sweden)

    Peter Ackland

    2012-01-01

    Full Text Available In the first 12 years of VISION 2020 sound programmatic approaches have been developed that are capable of delivering equitable eye health services to even the most remote and impoverished communities. A body of evidence around the economic arguments for investment in eye health has been developed that has fuelled successful advocacy work resulting in supportive high level policy statements. More than a 100 national plans to achieve the elimination of avoidable blindness have been developed and some notable contributions made from the corporate and government sectors to resource eye health programs. Good progress has been made to control infectious blinding diseases and at the very least there is anecdotal evidence to suggest that the global increase in the prevalence of blindness and visual impairment has been reversed in recent years, despite the ever increasing and more elderly global population. However if we are to achieve the goal of VISION 2020 we require a considerable scaling up of current efforts-this will depend on our future success in two key areas: i Successful advocacy and engagement at individual country level to secure significantly enhanced national government commitment to financing their own VISION 2020 plans.ii A new approach to VISION 2020 thinking that integrates eye health into health system development and develops new partnerships with wider health development initiatives.

  2. WHO European Childhood Obesity Surveillance Initiative 2008: weight, height and body mass index in 6-9-year-old children.

    LENUS (Irish Health Repository)

    Wijnhoven, T M A

    2012-09-21

    What is already known about this subject Overweight and obesity prevalence estimates among children based on International Obesity Task Force definitions are substantially lower than estimates based on World Health Organization definitions. Presence of a north-south gradient with the highest level of overweight found in southern European countries. Intercountry comparisons of overweight and obesity in primary-school children in Europe based on measured data lack a similar data collection protocol. What this study adds Unique dataset on overweight and obesity based on measured weights and heights in 6-9-year-old children from 12 European countries using a harmonized surveillance methodology. Because of the use of a consistent data collection protocol, it is possible to perform valid multiple comparisons between countries. It demonstrates wide variations in overweight and obesity prevalence estimates among primary-school children between European countries and regions. BACKGROUND: Nutritional surveillance in school-age children, using measured weight and height, is not common in the European Region of the World Health Organization (WHO). The WHO Regional Office for Europe has therefore initiated the WHO European Childhood Obesity Surveillance Initiative. OBJECTIVE: To present the anthropometric results of data collected in 2007\\/2008 and to investigate whether there exist differences across countries and between the sexes. METHODS: Weight and height were measured in 6-9-year-old children in 12 countries. Prevalence of overweight, obesity, stunting, thinness and underweight as well as mean Z-scores of anthropometric indices of height, weight and body mass index were calculated. RESULTS: A total of 168 832 children were included in the analyses and a school participation rate of more than 95% was obtained in 8 out of 12 countries. Stunting, underweight and thinness were rarely prevalent. However, 19.3-49.0% of boys and 18.4-42.5% of girls were overweight (including

  3. [Review] Polarization and Polarimetry

    Science.gov (United States)

    Trippe, Sascha

    2014-02-01

    Polarization is a basic property of light and is fundamentally linked to the internal geometry of a source of radiation. Polarimetry complements photometric, spectroscopic, and imaging analyses of sources of radiation and has made possible multiple astrophysical discoveries. In this article I review (i) the physical basics of polarization: electromagnetic waves, photons, and parameterizations; (ii) astrophysical sources of polarization: scattering, synchrotron radiation, active media, and the Zeeman, Goldreich-Kylafis, and Hanle effects, as well as interactions between polarization and matter (like birefringence, Faraday rotation, or the Chandrasekhar-Fermi effect); (iii) observational methodology: on-sky geometry, influence of atmosphere and instrumental polarization, polarization statistics, and observational techniques for radio, optical, and X/γ wavelengths; and (iv) science cases for astronomical polarimetry: solar and stellar physics, planetary system bodies, interstellar matter, astrobiology, astronomical masers, pulsars, galactic magnetic fields, gamma-ray bursts, active galactic nuclei, and cosmic microwave background radiation.

  4. Ancient Hybridization and an Irish Origin for the Modern Polar Bear Matriline

    Science.gov (United States)

    Edwards, Ceiridwen J.; Suchard, Marc A.; Lemey, Philippe; Welch, John J.; Barnes, Ian; Fulton, Tara L.; Barnett, Ross; O’Connell, Tamsin C.; Coxon, Peter; Monaghan, Nigel; Valdiosera, Cristina E.; Lorenzen, Eline D.; Willerslev, Eske; Baryshnikov, Gennady F.; Rambaut, Andrew; Thomas, Mark G.; Bradley, Daniel G.; Shapiro, Beth

    2015-01-01

    Summary Background Polar bears (Ursus maritimus) are among those species most susceptible to the rapidly changing arctic climate, and their survival is of global concern. Despite this, little is known about polar bear species history. Future conservation strategies would significantly benefit from an understanding of basic evolutionary information, such as the timing and conditions of their initial divergence from brown bears (U. arctos) or their response to previous environmental change. Results We used a spatially explicit phylogeographic model to estimate the dynamics of 242 brown bear and polar bear matrilines sampled throughout the last 120,000 years and across their present and past geographic ranges. Our results show that the present distribution of these matrilines was shaped by a combination of regional stability and rapid, long-distance dispersal from ice-age refugia. In addition, hybridization between polar bears and brown bears may have occurred multiple times throughout the Late Pleistocene. Conclusions The reconstructed matrilineal history of brown and polar bears has two striking features. First, it is punctuated by dramatic and discrete climate-driven dispersal events. Second, opportunistic mating between these two species as their ranges overlapped has left a strong genetic imprint. In particular, a likely genetic exchange with extinct Irish brown bears forms the origin of the modern polar bear matriline. This suggests that interspecific hybridization not only may be more common than previously considered but may be a mechanism by which species deal with marginal habitats during periods of environmental deterioration. PMID:21737280

  5. Polarization feedback laser stabilization

    Science.gov (United States)

    Esherick, P.; Owyoung, A.

    1987-09-28

    A system for locking two Nd:YAG laser oscillators includes an optical path for feeding the output of one laser into the other with different polarizations. Elliptical polarization is incorporated into the optical path so that the change in polarization that occurs when the frequencies coincide may be detected to provide a feedback signal to control one laser relative to the other. 4 figs.

  6. Polarization in Sagittarius A*

    OpenAIRE

    Bower, Geoffrey C.

    2000-01-01

    We summarize the current state of polarization observations of Sagittarius A*, the compact radio source and supermassive black hole candidate in the Galactic Center. These observations are providing new tools for understanding accretion disks, jets and their environments. Linear polarization observations have shown that Sgr A* is unpolarized at frequencies as high as 86 GHz. However, recent single-dish observations indicate that Sgr A* may have strong linear polarization at frequencies higher...

  7. Electron spin polarization effects in low energy electron diffraction, ion neutralization and metastable atom deexcitation at solid surfaces. Progress report No. 4, 1 January-31 December 1984

    International Nuclear Information System (INIS)

    1984-01-01

    In the present contract year, a GaAs polarized electron source has been used to undertake a polarized LEED study of order-disorder transformations at Cu 3 Au (100) and (111) surfaces. A polarized LEED study of Cu (100) has also been initiated. A polarized MDS study of Ni(110) surface magnetism has been completed. Spin dependences in the Auger electron yield were observed that provide a measure of the surface magnetism and were used to probe the dependence of surface magnetism on temperature and adsorbate coverage. A similar study using a ferromagnetic glass is now underway. A Mott polarization analyzer, constructed to measure the ESP of the ejected electrons, is also being installed on the apparatus. Such measurements provide direct information concerning the dynamics of secondary electron ejection and the details of adsorbate-substrate bonding

  8. Not All Clefts Are Created Equal: Patterns of Hospital-Based Care Use among Children with Cleft Lip and Palate within 4 Years of Initial Surgery.

    Science.gov (United States)

    Ligh, Cassandra A; Fox, Justin P; Swanson, Jordan; Yu, Jason W; Taylor, Jesse A

    2016-06-01

    This study compares hospital-based care and associated charges among children with cleft lip, cleft palate, or both, and identifies subgroups generating the greatest cumulative hospital charges. The authors conducted a retrospective cohort study of cleft lip, cleft palate, or cleft lip and palate who underwent initial surgery from 2006 to 2008 in four U.S. states. Primary outcome was hospital-based care-emergency, outpatient, inpatient-within 4 years of surgery. Regression models compared outcomes and classification tree analysis identified patients at risk for being in the highest quartile of cumulative hospital charges. The authors identified 4571 children with cleft lip (18.2 percent), cleft palate (39.2 percent), or cleft lip and palate (42.6 percent). Medical comorbidity was frequent across all groups, with feeding difficulty (cleft lip, 2.4 percent; cleft palate, 13.4 percent; cleft lip and palate, 6.0 percent; p cleft lip, 1.8 percent; cleft palate, 9.4 percent; cleft lip and palate, 3.6 percent; p cleft palate were most likely to return to the hospital (p cleft lip group, yet comparable among those with cleft palate and cleft lip and palate (p cleft palate cohort (cleft lip, $56,966; cleft palate, $106,090; cleft lip and palate, $91,263; p cleft lip versus cleft palate with or without cleft lip), and age at initial surgery were the most important factors associated with the highest quartile of cumulative hospital charges. Cleft lip and palate children experience a high rate of hospital-based care early in life, with degree of medical comorbidity being a significant burden. Understanding this relationship and associated needs may help deliver more efficient, patient-centered care.

  9. Airborne Laser Polarization Sensor

    Science.gov (United States)

    Kalshoven, James, Jr.; Dabney, Philip

    1991-01-01

    Instrument measures polarization characteristics of Earth at three wavelengths. Airborne Laser Polarization Sensor (ALPS) measures optical polarization characteristics of land surface. Designed to be flown at altitudes of approximately 300 m to minimize any polarizing or depolarizing effects of intervening atmosphere and to look along nadir to minimize any effects depending on look angle. Data from measurements used in conjunction with data from ground surveys and aircraft-mounted video recorders to refine mathematical models used in interpretation of higher-altitude polarimetric measurements of reflected sunlight.

  10. Polarization at SLC

    International Nuclear Information System (INIS)

    Swartz, M.L.

    1988-07-01

    The SLAC Linear Collider has been designed to readily accommodate polarized electron beams. Considerable effort has been made to implement a polarized source, a spin rotation system, and a system to monitor the beam polarization. Nearly all major components have been fabricated. At the current time, several source and polarimeter components have been installed. The installation and commissioning of the entire system will take place during available machine shutdown periods as the commissioning of SLC progresses. It is expected that a beam polarization of 45% will be achieved with no loss in luminosity. 13 refs., 15 figs

  11. Exploring Science Through Polar Exploration

    Science.gov (United States)

    Pfirman, S. L.; Bell, R. E.; Zadoff, L.; Kelsey, R.

    2003-12-01

    Exploring the Poles is a First Year Seminar course taught at Barnard College, Columbia University. First Year Seminars are required of incoming students and are designed to encourage critical analysis in a small class setting with focused discussion. The class links historical polar exploration with current research in order to: introduce non-scientists to the value of environmental science through polar literature; discuss issues related to venturing into the unknown that are of relevance to any discipline: self-reliance, leadership, preparation, decisions under uncertainty; show students the human face of science; change attitudes about science and scientists; use data to engage students in exploring/understanding the environment and help them learn to draw conclusions from data; integrate research and education. These goals are met by bringing analysis of early exploration efforts together with a modern understanding of the polar environment. To date to class has followed the efforts of Nansen in the Fram, Scott and Amundsen in their race to the pole, and Shackleton's Endurance. As students read turn-of-the-century expedition journals, expedition progress is progressively revealed on an interactive map showing the environmental context. To bring the exploration process to life, students are assigned to expedition teams for specific years and the fates of the student "expeditions" are based on their own decisions. For example, in the Arctic, they navigate coastal sea ice and become frozen into the ice north of Siberia, re-creating Nansen's polar drift. Fates of the teams varied tremendously: some safely emerged at Fram Strait in 4 years, while others nearly became hopelessly lost in the Beaufort Gyre. Students thus learn about variability in the current polar environment through first hand experience, enabling them to appreciate the experiences, decisions, and, in some cases, the luck, of polar explorers. Evaluation by the Columbia Center for New Media, Teaching

  12. Polarized gas targets for storage rings

    International Nuclear Information System (INIS)

    Holt, R.J.

    1990-01-01

    It is widely recognized that polarized gas targets in electron storage rings represent a new opportunity for precision nuclear physics studies. New developments in polarized target technology specific to internal applications will be discussed. In particular, polarized gas targets have been used in the VEPP-3 electron ring in Novosibirsk. A simple storage cell was used to increase the total target thickness by a factor of 15 over the simple gas jet target from an atomic beam source. Results from the initial phase of this project will be reported. In addition, the plans for increasing the luminosity by an additional order or magnitude will be presented. The application of this work to polarized hydrogen and deuterium targets for the HERA ring will be noted. The influence of beam-induced depolarization, a phenomena encountered in short-pulse electron storage rings, will be discussed. Finally, the performance tests of laser-driven sources will be presented. 8 refs., 12 figs., 1 tab

  13. Scattering Polarization in Solar Flares

    Czech Academy of Sciences Publication Activity Database

    Štěpán, Jiří; Heinzel, Petr

    2013-01-01

    Roč. 778, č. 1 (2013), L6/1-L6/6 ISSN 2041-8205 R&D Projects: GA ČR GAP209/12/1652; GA ČR GPP209/12/P741 Institutional support: RVO:67985815 Keywords : line formation * polarization * radiative transfer Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics Impact factor: 5.602, year: 2013

  14. PolarTREC-Celebrating the Legacy of the IPY Through Researcher-Educator Partnerships

    Science.gov (United States)

    Timm, K.; Warburton, J.; Larson, A. M.

    2009-12-01

    Polar TREC-Teachers and Researchers Exploring and Collaborating, a three-year (2007-2009) NSF-funded program, has matched over 40 teachers with polar researchers working in multiple scientific disciplines for 2-8 week Teacher Research Experiences (TRE) in the Arctic and Antarctica during the IPY. PolarTREC contributes to the legacy of the IPY through the creation and dissemination of polar education resources, prolonged teacher-researcher relationships, and contributions to scholarly knowledge on the impacts of TRE's. Products developed during PolarTREC are helping to sustain the widespread interest and enthusiasm in the polar regions generated during the IPY. During their expeditions, participating teachers brought science and information about profound changes at the poles to school, community, and professional audiences through web-based communications, journals, discussion forums, multimedia, and live events. PolarTREC teachers constructed nearly 100 classroom lesson plans and activities as products of their experiences. Live events from the field attracted over 11,000 participants, primarily K-12 students. Although the field experience is central to the PolarTREC TRE Model, many participants cite the relationship they built with their teacher/researcher as one of the best outcomes. Through personal communications, presentations at professional conferences, and continued support of each other’s work through classroom visits or joint proposal development, teachers and researchers have maintained the mutually beneficial relationships established during the IPY. Participating scientists gained access to professional educators with expertise in translating research approaches and results into programs. The need for researchers to explain their research and “boil it down to the raw essence” helped many see how their work fits into a bigger picture, often helping them communicate outside their scientific discipline and to diverse public audiences. Teachers, on

  15. High eccentric hip abduction strength reduces the risk of developing patellofemoral pain among novice runners initiating a self-structured running program: a 1-year observational study.

    Science.gov (United States)

    Ramskov, Daniel; Barton, Christian; Nielsen, Rasmus O; Rasmussen, Sten

    2015-03-01

    Observational prospective cohort study with 1-year follow-up. To investigate the relationship between eccentric hip abduction strength and the development of patellofemoral pain (PFP) in novice runners during a self-structured running regime. Recent research indicates that gluteal muscle weakness exists in individuals with PFP. However, current prospective research has been limited to the evaluation of isometric strength, producing inconsistent findings. Considering that hip muscles, including the gluteus maximus and medius, activate eccentrically to control hip and pelvic motion during weight-bearing activities such as running, the potential link between eccentric strength and PFP risk should be evaluated. Eight hundred thirty-two novice runners were included at baseline, and 629 participants were included in the final analysis. Maximal eccentric hip abduction strength was measured using a handheld dynamometer prior to initiating a self-structured running program. The diagnostic criteria to classify knee pain as PFP were based on a thorough clinical examination. Participants were followed for 12 months and training characteristics were gathered with a global positioning system. Results from the unadjusted generalized linear regression model for cumulative risk at 25 and 50 km indicated differences in cumulative risk of PFP between high strength, normal strength, and low strength (Pabduction strength that is higher than normal may reduce the risk of PFP during the first 50 km of a self-structured running program.

  16. Our Polar Past

    Science.gov (United States)

    Clary, Renee; Wandersee, James

    2009-01-01

    The study of polar exploration is fascinating and offers students insights into the history, culture, and politics that affect the developing sciences at the farthest ends of Earth. Therefore, the authors think there is value in incorporating polar exploration accounts within modern science classrooms, and so they conducted research to test their…

  17. Terahertz polarization imaging

    NARCIS (Netherlands)

    Van der Valk, N.C.J.; Van der Marel, W.A.M.; Planken, P.C.M.

    2005-01-01

    We present a new method to measure the polarization state of a terahertz pulse by using a modified electrooptic sampling setup. To illustrate the power of this method, we show two examples in which the knowledge of the polarization of the terahertz pulse is essential for interpreting the results:

  18. Polarized proton beams

    International Nuclear Information System (INIS)

    Roser, T.

    1995-01-01

    The acceleration of polarized proton beams in circular accelerators is complicated by the presence of numerous depolarizing spin resonances. Careful and tedious minimization of polarization loss at each of these resonances allowed acceleration of polarized proton beams up to 22 GeV. It has been the hope that Siberian Snakes, which are local spin rotators inserted into ring accelerators, would eliminate these resonances and allow acceleration of polarized beams with the same ease and efficiency that is now routine for unpolarized beams. First tests at IUCF with a full Siberian Snake showed that the spin dynamics with a Snake can be understood in detail. The author now has results of the first tests of a partial Siberian Snake at the AGS, accelerating polarized protons to an energy of about 25 GeV. These successful tests of storage and acceleration of polarized proton beams open up new possibilities such as stored polarized beams for internal target experiments and high energy polarized proton colliders

  19. Polar Science Is Cool!

    Science.gov (United States)

    Weeks, Sophie

    2012-01-01

    Children are fascinated by the fact that polar scientists do research in extremely cold and dangerous places. In the Arctic they might be viewed as lunch by a polar bear. In the Antarctic, they could lose toes and fingers to frostbite and the wind is so fast it can rip skin off. They camp on ice in continuous daylight, weeks from any form of…

  20. Precision Polarization of Neutrons

    Science.gov (United States)

    Martin, Elise; Barron-Palos, Libertad; Couture, Aaron; Crawford, Christopher; Chupp, Tim; Danagoulian, Areg; Estes, Mary; Hona, Binita; Jones, Gordon; Klein, Andi; Penttila, Seppo; Sharma, Monisha; Wilburn, Scott

    2009-05-01

    Determining polarization of a cold neutron beam to high precision is required for the next generation neutron decay correlation experiments at the SNS, such as the proposed abBA and PANDA experiments. Precision polarimetry measurements were conducted at Los Alamos National Laboratory with the goal of determining the beam polarization to the level of 10-3 or better. The cold neutrons from FP12 were polarized using optically polarized ^3He gas as a spin filter, which has a highly spin-dependent absorption cross section. A second ^ 3He spin filter was used to analyze the neutron polarization after passing through a resonant RF spin rotator. A discussion of the experiment and results will be given.

  1. Optically polarized 3He

    Science.gov (United States)

    Gentile, T. R.; Nacher, P. J.; Saam, B.; Walker, T. G.

    2018-01-01

    This article reviews the physics and technology of producing large quantities of highly spin-polarized 3He nuclei using spin-exchange (SEOP) and metastability-exchange (MEOP) optical pumping. Both technical developments and deeper understanding of the physical processes involved have led to substantial improvements in the capabilities of both methods. For SEOP, the use of spectrally narrowed lasers and K-Rb mixtures has substantially increased the achievable polarization and polarizing rate. For MEOP nearly lossless compression allows for rapid production of polarized 3He and operation in high magnetic fields has likewise significantly increased the pressure at which this method can be performed, and revealed new phenomena. Both methods have benefitted from development of storage methods that allow for spin-relaxation times of hundreds of hours, and specialized precision methods for polarimetry. SEOP and MEOP are now widely applied for spin-polarized targets, neutron spin filters, magnetic resonance imaging, and precision measurements. PMID:29503479

  2. Optically polarized 3He

    Science.gov (United States)

    Gentile, T. R.; Nacher, P. J.; Saam, B.; Walker, T. G.

    2017-10-01

    This article reviews the physics and technology of producing large quantities of highly spin-polarized 3He nuclei using spin-exchange (SEOP) and metastability-exchange (MEOP) optical pumping. Both technical developments and deeper understanding of the physical processes involved have led to substantial improvements in the capabilities of both methods. For SEOP, the use of spectrally narrowed lasers and K-Rb mixtures has substantially increased the achievable polarization and polarizing rate. For MEOP nearly lossless compression allows for rapid production of polarized 3He and operation in high magnetic fields has likewise significantly increased the pressure at which this method can be performed, and revealed new phenomena. Both methods have benefitted from development of storage methods that allow for spin-relaxation times of hundreds of hours, and specialized precision methods for polarimetry. SEOP and MEOP are now widely applied for spin-polarized targets, neutron spin filters, magnetic resonance imaging, and precision measurements.

  3. Parallel Polarization State Generation.

    Science.gov (United States)

    She, Alan; Capasso, Federico

    2016-05-17

    The control of polarization, an essential property of light, is of wide scientific and technological interest. The general problem of generating arbitrary time-varying states of polarization (SOP) has always been mathematically formulated by a series of linear transformations, i.e. a product of matrices, imposing a serial architecture. Here we show a parallel architecture described by a sum of matrices. The theory is experimentally demonstrated by modulating spatially-separated polarization components of a laser using a digital micromirror device that are subsequently beam combined. This method greatly expands the parameter space for engineering devices that control polarization. Consequently, performance characteristics, such as speed, stability, and spectral range, are entirely dictated by the technologies of optical intensity modulation, including absorption, reflection, emission, and scattering. This opens up important prospects for polarization state generation (PSG) with unique performance characteristics with applications in spectroscopic ellipsometry, spectropolarimetry, communications, imaging, and security.

  4. Eesti Rahva Muuseumi strateegiad ja praktikad rahvaga suhtlemisel muuseumi algusaastatel / Estonian National Museum: Public communication strategies and practices in the initial years

    Directory of Open Access Journals (Sweden)

    Piret Õunapuu

    2012-01-01

    Full Text Available Until recently the museum phenomenon as the valuator of the indigenous culture in the context of the awakening national consciousness has received little attention. The evolution of the idea of the Estonian National Museum (ENM and its realization reflects the story of the Estonian people maturing into a nation. The museum was founded by a few dedicated persons and it took a long time before the general public recognised it as the museum for the Estonian people. The main purpose of this research is to ascertain how relations developed between the public and the museum in its initial years and what were the museum strategies in declaring its objectives. After the official foundation of the ENM in 1909 the museum narrative can be divided into two main parts. First, work inside the museum, the compilation and arrangement of collections. This was, above all, the work of the collection committee and organizing heritage collection trips. Collections constitute the basis of a museum – therefore the primary and most important task of the established museum was the collection of heritage items. The collections were started immediately after the foundation of the museum; within the first ten years approximately 20,000 items were collected, approximately two thirds of the items in the years 1911–1913. The phenomenon that a museum where people worked mainly without a salary for the benefit of their homeland, with the set aim to empty the whole of Estonia of heritage items parish by parish and succeeded in engaging dozens and dozens of people for this work, is probably exceptional in world history. As a result, the museum acquired not only voluminous but also valuable item collections, which reached the museum before the devastating First World War. The timing was favourable. There were enough old artefacts left, although most collectors complained in their diaries that there was nothing interesting to be found any more. However, the majority of the

  5. Changes in RANKL during the first two years after cART initiation in HIV-infected cART naïve adults

    DEFF Research Database (Denmark)

    Mathiesen, Inger Hee Mabuza; Salem, Mohammad; Gerstoft, Jan

    2017-01-01

    BACKGROUND: By assessing the changes in concentration of soluble receptor activator of nuclear factor κ B ligand (RANKL) and osteoprotegrin (OPG) after initiation of combination antiretroviral therapy (cART) in treatment-naïve HIV-infected patients we aimed to evaluate whether the initial...... accelerated bone loss could be mediated by increased soluble RANKL (sRANKL) levels associated with CD4+ T cell recovery. METHODS: We used multiplex immunoassays to determine sRANKL and OPG concentrations in plasma from 48 HIV patients at baseline and 12, 24, 48 and 96 weeks after cART initiation. RESULTS...... and changes in sRANKL. CONCLUSION: In this study there was no indication that the accelerated bone loss after cART initiation was mediated by early changes in sRANKL due to CD4+ T cell recovery. Future studies should focus on the initial weeks after initiation of cART. TRIAL REGISTRATION: Clinical...

  6. Physics with polarization at the SLD

    International Nuclear Information System (INIS)

    Burrows, P.N.

    1990-05-01

    The SLD detector is nearing completion and will start physics-quality data-taking at the SLC in 1991 with a longitudinally polarized electron beam and unpolarized positron beam. The current status of the detector is reviewed and the rich program of physics measurements possible with polarization and the SLD detector is briefly presented. In particular, the left-right polarization asymmetry, A LR , will be a unique measurement for the next few years and will allow tight bounds to be set upon the mass of the top quark. 14 refs., 1 fig

  7. Characterization of Partially Polarized Light Fields

    CERN Document Server

    Martínez-Herrero, Rosario; Piquero, Gemma

    2009-01-01

    Polarization involves the vectorial nature of light fields. In current applications of optical science, the electromagnetic description of light with its vector features has been shown to be essential: In practice, optical radiation also exhibits randomness and spatial non-uniformity of the polarization state. Moreover, propagation through photonic devices can alter the correlation properties of the light field, resulting in changes in polarization. All these vectorial properties have been gaining importance in recent years, and they are attracting increasing attention in the literature. This is the framework and the scope of the present book, which includes the authors’ own contributions to these issues.

  8. Alaskan Exemplary Program The Rural Alaska Honors Institute (RAHI) A Quarter Century of Success of Educating, Nurturing, and Retaining Alaska Native and Rural Students An International Polar Year Adventure in Barrow

    Science.gov (United States)

    Wartes, D.; Owens, G.

    2007-12-01

    UA system who participated in RAHI are nearly twice as likely to earn a bachelors degree, than those who did not attend RAHI. This summer, in celebration of the International Polar Year, in collaboration with Ilisagvik College, at the completion of the traditional RAHI program, ten RAHI students flew to Barrow for an additional two weeks of study. Five students participated in an archaeological dig and five students performed research with the Barrow Arctic Science Consortium scientists studying climate change. In addition, ten students from Greenland visited the program, with plans to more fully participate next summer. This added dimension to the program has proved successful, allowing the students to compare and contrast between their own countries and indigenous perspectives. Global warming was an issue that was hotly debated, as its effects are so evident in the Polar Regions. In the Arctic, life is directly tied to the ice and snow. As the ice disappears and/or changes, the Indigenous people have to adapt. RAHI would like to share with you some of the results of this past summers IPY activities.

  9. Coherent ρ production from polarized deuterium

    International Nuclear Information System (INIS)

    Frankfurt, L.; Sargsian, M.; Sargsian, M.

    1996-01-01

    We discuss the coherent leptoproduction of vector mesons from polarized deuterium as a tool to investigate the evolution of small size quark-gluon configurations. Kinematic regions are determined where the final state interaction of the initially produced quark-gluon wave packet contributes dominantly to the production cross section. Two methods for an investigation of color coherence effects are suggested. (author)

  10. Electrical polarization of lead bromide crystals. II

    NARCIS (Netherlands)

    Schoonman, J.; Dijkman, F.G.

    Electrical currents are measured as a function of time after application of a dc voltage on a cell arragement +C/PbBr2/C-. The presence of nonlinear polarization phenomena has been established from a test of Ohm's law, the superposition principle, and from initial and steady-state conductivities

  11. Latest on polarization in electron storage rings

    International Nuclear Information System (INIS)

    Chao, A.W.

    1983-01-01

    The field of beam polarization in electron storage rings is making rapid progress in recent several years. This report is an attempt to summarize some of these developments concerning how to produce and maintain a high level of beam polarization. Emphasized will be the ideas and current thoughts people have on what should and could be done on electron rings being designed at present such as HERA, LEP and TRISTAN. 23 references

  12. Changes in RANKL during the first two years after cART initiation in HIV-infected cART naïve adults

    DEFF Research Database (Denmark)

    Mathiesen, Inger Hee; Salem, Mohammad; Gerstoft, Jan

    2017-01-01

    Background: By assessing the changes in concentration of soluble receptor activator of nuclear factor Κ B ligand (RANKL) and osteoprotegrin (OPG) after initiation of combination antiretroviral therapy (cART) in treatment-naïve HIV-infected patients we aimed to evaluate whether the initial acceler...

  13. Polarization at the SLC

    Energy Technology Data Exchange (ETDEWEB)

    Moffeit, K.C.

    1988-10-01

    The Stanford Linear collider was designed to accommodate polarized electron beams. Longitudinally polarized electrons colliding with unpolarized positrons at a center of mass energy near the Z/sup 0/ mass can be used as novel and sensitive probes of the electroweak process. A gallium arsenide based photon emission source will provide a beam of longitudinally polarized electrons of about 45 percent polarization. A system of bend magnets and a superconducting solenoid will be used to rotate the spins so that the polarization is preserved while the 1.21 GeV electrons are stored in the damping ring. Another set of bend magnets and two superconducting solenoids orient the spin vectors so that longitudinal polarization of the electrons is achieved at the collision point with the unpolarized positrons. A system to monitor the polarization based on Moller and Compton scattering will be used. Nearly all major components have been fabricated and tested. Subsystems of the source and polarimeters have been installed, and studies are in progress. The installation and commissioning of the entire system will take place during available machine shutdown periods as the commissioning of SLC progresses. 8 refs., 16 figs., 1 tab.

  14. Family time, parental behaviour model and the initiation of smoking and alcohol use by ten-year-old children: an epidemiological study in Kaunas, Lithuania

    Directory of Open Access Journals (Sweden)

    Zaborskis Apolinaras

    2006-11-01

    Full Text Available Abstract Background Family is considered to be the first and the most important child development and socialization bond. Nevertheless, parental behaviour model importance for the children, as well as family time for shared activity amount influence upon the child's health-related behaviour habit development has not been yet thoroughly examined. The aim of this paper is to indicate the advanced health-hazardous behaviour modelling possibilities in the families, as well as time spent for joint family activities, and to examine the importance of time spent for joint family activities for the smoking and alcohol use habit initiation among children. Methods This research was carried out in Kaunas, Lithuania, during the school year 2004–2005. The research population consisted of 369 fifth-grade schoolchildren (211 (57.2% boys and 158 (42.8% girls and 565 parents: 323 (57.2% mothers and 242 (48.2% fathers. The response rate was 80.7% for children; 96.1% and 90.6% for mothers and fathers correspondingly. Results Eating a meal together was the most frequent joint family activity, whereas visiting friends or relatives together, going for a walk, or playing sports were the most infrequent joint family activities. More than two thirds (81.5% of parents (248 (77.0% mothers and 207 (85.9% fathers (p Conclusion Joint family activity time deficit together with frequent parental examples of smoking and alcohol use underlie the development of alcohol and smoking addictions in children to some extent. The above-mentioned issues are suggested to be widely addressed in the comprehensive family health education programs.

  15. Live Donors of the Initial Observational Study of Uterus Transplantation-Psychological and Medical Follow-Up Until 1 Year After Surgery in the 9 Cases.

    Science.gov (United States)

    Kvarnström, Niclas; Järvholm, Stina; Johannesson, Liza; Dahm-Kähler, Pernilla; Olausson, Michael; Brännström, Mats

    2017-03-01

    The first prospective observational study of uterus transplantation was initiated in 2013 with live donation to 9 women with absolute uterine factor infertility. We explored the medical complications and psychosocial wellbeing of the donors during the first postoperative year. Complications were registered and graded according to the Clavien-Dindo (C-D) classification. Symptoms related to the surgery were registered. Data on length of hospital stay, sick leave, socioeconomic parameters, and life events were obtained. Psychological evaluations (Psychological General Well-Being, Dyadic Adjustment Scale, Hospital Anxiety and Depression Scale [HADS], SF-36) questionnaires focusing on quality of life, mood, and relationship, were conducted at inclusion and at 3, 6, and 12 months after uterus donation. One major surgical complication (C-D IIIb) occurred. A ureteric-vaginal fistula developed 2 weeks after uterus procurement. The fistula was surgically repaired. Two self-reported and transient complications (C-D I) were noted (nocturia, meralgia paresthetica). Hospital stays of all donors were 6 days and median sick leave was 56 days (range, 14-132). At inclusion, median scores exceeded the normative values of the Swedish population in Psychological General Well-Being and Dyadic Adjustment Scale. HADS-Anxiety was detected preoperatively in 1 donor. Two donors exceeded 10-point declines in SF-36 summary scores and increased their HADS scores by 6 points during the observation period. All donors returned to their predonation levels of physical health. The results support that it is feasible to retrieve a uterus safely from a live donor. Further studies are needed to better evaluate the method.

  16. Semi-automatic lung segmentation of DCE-MRI data sets of 2-year old children after congenital diaphragmatic hernia repair: Initial results.

    Science.gov (United States)

    Zöllner, Frank G; Daab, Markus; Weidner, Meike; Sommer, Verena; Zahn, Katrin; Schaible, Thomas; Weisser, Gerald; Schoenberg, Stefan O; Neff, K Wolfgang; Schad, Lothar R

    2015-12-01

    In congenital diaphragmatic hernia (CDH), lung hypoplasia and secondary pulmonary hypertension are the major causes of death and severe disability. Based on new therapeutic strategies survival rates could be improved to up to 80%. However, after surgical repair of CDH, long-term follow-up of these pediatric patients is necessary. In this, dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) provides insights into the pulmonary microcirculation and might become a tool within the routine follow-up program of CDH patients. However, whole lung segmentation from DCE-MRI scans is tedious and automated procedures are warranted. Therefore, in this study, an approach to semi-automated lung segmentation is presented. Segmentation of the lung is obtained by calculating the cross correlation and the area under curve between all voxels in the data set and a reference region-of-interest (ROI), here the arterial input function (AIF). By applying an upper and lower threshold to the obtained maps and intersecting these, a final segmentation is reached. This approach was tested on twelve DCE-MRI data sets of 2-year old children after CDH repair. Segmentation accuracy was evaluated by comparing obtained automatic segmentations to manual delineations using the Dice overlap measure. Optimal thresholds for the cross correlation were 0.5/0.95 and 0.1/0.5 for the area under curve, respectively. The ipsilateral (left) lung showed reduced segmentation accuracy compared to the contralateral (right) lung. Average processing time was about 1.4s per data set. Average Dice score was 0.7±0.1 for the whole lung. In conclusion, initial results are promising. By our approach, whole lung segmentation is possible and a rapid evaluation of whole lung perfusion becomes possible. This might allow for a more detailed analysis of lung hypoplasia of children after CDH. Copyright © 2015 Elsevier Inc. All rights reserved.

  17. Material and device studies for the development of ultra-violet light emitting diodes (UV-LEDS) along polar, non-polar and semi-polar directions

    Science.gov (United States)

    Chandrasekaran, Ramya

    Over the past few years, significant effort was dedicated to the development of ultraviolet light emitting diodes (UV-LEDs) for a variety of applications. Such applications include chemical and biological detection, water purification and solid-state lighting. III-Nitride LEDs based on multiple quantum wells (MQWs) grown along the conventional [0001] (polar) direction suffer from the quantum confined Stark effect (QCSE), due to the existence of strong electric fields that arise from spontaneous and piezoelectric polarization. Thus, there is strong motivation to develop MQW-based III-nitride LED structures grown along non-polar and semi-polar directions. The goal of this dissertation is to develop UV-LEDs along the [0001] polar and [11 2¯ 0] non-polar directions by the method of Molecular Beam Epitaxy (MBE). The polar and non-polar LEDs were grown on the C-plane and R-plane sapphire substrates respectively. This work is a combination of materials science studies related to the nucleation, growth and n- and p-type doping of III-nitride films on these two substrates, as well as device studies related to fabrication and characterization of UV-LEDs. It was observed that the crystallographic orientation of the III-nitride films grown on R-plane sapphire depends strongly on the kinetic conditions of growth of the Aluminum Nitride (AIN) buffer. Specifically, growth of the AIN buffer under group III-rich conditions leads to nitride films having the (11 2¯ 0) non polar planes parallel to the sapphire surface, while growth of the buffer under nitrogen rich conditions leads to nitride films with the (11 2¯ 6) semi-polar planes parallel to the sapphire surface. The electron concentration and mobility for the films grown along the polar, non-polar and semi-polar directions were investigated. P-type doping of Gallium Nitride (GaN) films grown on the nonpolar (11 2¯ 0) plane do not suffer from polarity inversion and thus the material was doped p-type with a hole concentration

  18. Polarized atomic beams for targets

    International Nuclear Information System (INIS)

    Grueebler, W.

    1984-01-01

    The basic principle of the production of polarized atomic hydrogen and deuterium beams are reviewed. The status of the present available polarization, density and intensity are presented. The improvement of atomic beam density by cooling the hydrogen atoms to low velocity is discussed. The possible use of polarized atomic beams as targets in storage rings is shown. It is proposed that polarized atomic beams can be used to produce polarized gas targets with high polarization and greatly improved density

  19. Polarized scintillator targets

    Science.gov (United States)

    van den Brandt, B.; Bunyatova, E. I.; Hautle, P.; Konter, J. A.; Mango, S.

    2000-05-01

    The hydrogen nuclei in an organic scintillator have been polarized to more than 80% and the deuterons in its fully deuterated version to 24%. The scintillator, doped with TEMPO, has been polarized dynamically in a field of 2.5 T in a vertical dilution refrigerator in which a plastic lightguide transports the scintillation light from the sample in the mixing chamber to a photomultiplier outside the cryostat. Sizeable solid samples with acceptable optical properties and light output have been prepared and successfully operated as "live" polarized targets in nuclear physics experiments.

  20. Polarized scintillator targets

    Energy Technology Data Exchange (ETDEWEB)

    Brandt, B. van den E-mail: vandenbrandt@psi.ch; Bunyatova, E.I.; Hautle, P.; Konter, J.A.; Mango, S

    2000-05-21

    The hydrogen nuclei in an organic scintillator have been polarized to more than 80% and the deuterons in its fully deuterated version to 24%. The scintillator, doped with TEMPO, has been polarized dynamically in a field of 2.5 T in a vertical dilution refrigerator in which a plastic lightguide transports the scintillation light from the sample in the mixing chamber to a photomultiplier outside the cryostat. Sizeable solid samples with acceptable optical properties and light output have been prepared and successfully operated as 'live' polarized targets in nuclear physics experiments.

  1. Heidelberg polarized alkali source

    International Nuclear Information System (INIS)

    Kraemer, D.; Steffens, E.; Jaensch, H.; Philipps Universitaet, Marburg, Germany)

    1984-01-01

    A new atomic beam type polarized alkali ion source has been installed at Heidelberg. In order to improve the beam polarization considerably optical pumping is applied in combination with an adiabatic medium field transition which results in beams in single hyperfine sublevels. The m state population is determined by laser-induced fluorescence spectroscopy. Highly polarized beams (P/sub s/ > 0.9, s = z, zz) with intensities of 30 to 130 μA can be extracted for Li + and Na + , respectively

  2. Erosive progression is minimal, but erosion healing rare, in rheumatoid arthritis patients treated with adalimumab. A 1 year investigator-initiated follow-up study using high-resolution computed tomography as the primary outcome measure

    DEFF Research Database (Denmark)

    Møller Døhn, Uffe; Boonen, Annelies; Hetland, Merete Lund

    2008-01-01

    -grade radiographic erosions in the wrist or metacarpophalangeal (MCP) joints in the same (index) hand, initiated adalimumab 40 mg sc. eow. Thirty-five patients completed the study (median age 61 years (range 19-86), disease duration 8 years (0-36)). CT of index wrist and MCP2-5 and radiographs of hands and forefeet...

  3. Dynamic nuclear spin polarization

    Energy Technology Data Exchange (ETDEWEB)

    Stuhrmann, H.B. [GKSS-Forschungszentrum Geesthacht GmbH (Germany)

    1996-11-01

    Polarized neutron scattering from dynamic polarized targets has been applied to various hydrogenous materials at different laboratories. In situ structures of macromolecular components have been determined by nuclear spin contrast variation with an unprecedented precision. The experiments of selective nuclear spin depolarisation not only opened a new dimension to structural studies but also revealed phenomena related to propagation of nuclear spin polarization and the interplay of nuclear polarisation with the electronic spin system. The observation of electron spin label dependent nuclear spin polarisation domains by NMR and polarized neutron scattering opens a way to generalize the method of nuclear spin contrast variation and most importantly it avoids precontrasting by specific deuteration. It also likely might tell us more about the mechanism of dynamic nuclear spin polarisation. (author) 4 figs., refs.

  4. Time Domain Induced Polarization

    DEFF Research Database (Denmark)

    Fiandaca, Gianluca; Auken, Esben; Christiansen, Anders Vest

    2012-01-01

    Time-domain-induced polarization has significantly broadened its field of reference during the last decade, from mineral exploration to environmental geophysics, e.g., for clay and peat identification and landfill characterization. Though, insufficient modeling tools have hitherto limited the use...... of time-domaininduced polarization for wider purposes. For these reasons, a new forward code and inversion algorithm have been developed using the full-time decay of the induced polarization response, together with an accurate description of the transmitter waveform and of the receiver transfer function......%. Furthermore, the presence of low-pass filters in time-domain-induced polarization instruments affects the early times of the acquired decays (typically up to 100 ms) and has to be modeled in the forward response to avoid significant loss of resolution. The developed forward code has been implemented in a 1D...

  5. Polarized proton colliders

    International Nuclear Information System (INIS)

    Roser, T.

    1995-01-01

    High energy polarized beam collisions will open up the unique physics opportunities of studying spin effects in hard processes. This will allow the study of the spin structure of the proton and also the verification of the many well documented expectations of spin effects in perturbative QCD and parity violation in W and Z production. Proposals for polarized proton acceleration for several high energy colliders have been developed. A partial Siberian Snake in the AGS has recently been successfully tested and full Siberian Snakes, spin rotators, and polarimeters for RHIC are being developed to make the acceleration of polarized beams to 250 GeV possible. This allows for the unique possibility of colliding two 250 GeV polarized proton beams at luminosities of up to 2 x 10 32 cm -2 s -1

  6. Predictors of Human Papillomavirus Vaccine Initiation and Completion Among Latino Mothers of 11- to 17-Year-Old Daughters Living Along the Texas-Mexico Border.

    Science.gov (United States)

    Morales-Campos, Daisy Y; Parra-Medina, Deborah

    Few Texas Latino girls initiate and complete the human papillomavirus (HPV) vaccine series, but few studies have examined predictors of initiation and completion in this group. Mothers are crucial to vaccine uptake. Using self-reported data from mothers of unvaccinated girls (n = 317), we examined the association between predictors (HPV and HPV vaccine knowledge, vaccine self-efficacy) and outcomes (initiation and completion). Despite an increase in HPV and HPV vaccine knowledge from baseline to follow-up (n = 195), we found no association between the predictors and the outcomes. Findings showed that health insurance status and study group participation (Entre Madre e Hija program or brochure only) were associated with initiation and completion.

  7. Plasma polarization spectroscopy

    International Nuclear Information System (INIS)

    Iwamae, Atsushi; Horimoto, Yasuhiro; Fujimoto, Takashi; Hasegawa, Noboru; Sukegawa, Kouta; Kawachi, Tetsuya

    2005-01-01

    The electron velocity distribution function (EVDF) in plasma can be anisotropic in laser-produced plasmas. We have developed a new technique to evaluate the polarization degree of the emission lines in the extreme vacuum ultra violet wavelength region. The polarization of the emission lines and the continuums from the lithium-like nitrogen and from helium- and hydrogen-like carbon in recombining plasma is evaluated. Particle simulation in the velocity space gives the time scale for relaxation of anisotropic EVDFs. (author)

  8. Ultracold Polar Molecules

    Science.gov (United States)

    2016-04-01

    AFRL-AFOSR-UK-TR-2016-0005 Ultracold Polar Molecules Jeremy Hutson UNIVERSITY OF DURHAM Final Report 04/01/2016 DISTRIBUTION A: Distribution approved...DATES COVERED (From - To) 15-Jan-2010 to 14-Jul-2015 4. TITLE AND SUBTITLE Final Report on Grant FA8655-10-1-3033 on Ultracold Polar Molecules 5a...formation of ultracold 87RbCs molecules in their rovibrational ground state by magnetoassociation followed by STIRAP, resulting in 14 papers acknowledging

  9. The BNL polarized H- ion source development program

    International Nuclear Information System (INIS)

    Kponou, A.; Alessi, J.; Hershcovitch, A.; DeVito, B.

    1992-01-01

    Polarized protons have been available for acceleration in the AGS for the high energy physics program since 1984. The polarized H - source, PONI-1, has routinely supplied a 0.4 Hz, 400 μsec pulse having a nominal intensity of 40 μA. Polarization is ∼80% out of the ion source. After PONI- 1 became operational, a program was initiated to develop a more intense source based on a cold ground state atomic beam source, followed by ionization of the polarized H degrees beam by D - charge exchange. Various phases of this work have been fully reported elsewhere, and only a summary is given here

  10. Hsp Polarization Verification

    Science.gov (United States)

    Bless, Robert

    1991-07-01

    This proposal defines the procedure for determining the instrumental polarization of the polarimetric IDT (IDT#1, POL) on the HSP. 1 of 2 unpolarized standard stars wil be observed using various filter-polarizer combinations. These observations will permit the instrumental polarization to be calibrated. The instrumental polarization must be determined to a high precision in order to vectoriallly remove it from HSP polarization observations to determine the actual astronomical polarization. Final run of proposal will look at one of 2 possible stars previously observed to get another look at the throughput. Revision History: Mark H. Slovak 8/30/88 Translated to V2 proposal instructions (RPSS V6.2) S. Laurent 1/20/89 Updated: Sally Laurent 2/24/89, 3/20/89, 4/13/89, 5/12/89 Modified: P. Stanley 1/15/90 - change to use CTA selected targets only; Fixes for aberration problem - SALM 7/30/90; Based on SV/HSP 1386. New submission changed targets and revised scheduling strategy. Revised: 26 Aug 92 J. Dolan, L. Walter, P. Reppert want to re-run the proposal (3985) one last time to bring down errors.

  11. Venus's southern polar vortex reveals precessing circulation.

    Science.gov (United States)

    Luz, D; Berry, D L; Piccioni, G; Drossart, P; Politi, R; Wilson, C F; Erard, S; Nuccilli, F

    2011-04-29

    Initial images of Venus's south pole by the Venus Express mission have shown the presence of a bright, highly variable vortex, similar to that at the planet's north pole. Using high-resolution infrared measurements of polar winds from the Venus Express Visible and Infrared Thermal Imaging Spectrometer (VIRTIS) instrument, we show the vortex to have a constantly varying internal structure, with a center of rotation displaced from the geographic south pole by ~3 degrees of latitude and that drifts around the pole with a period of 5 to 10 Earth days. This is indicative of a nonsymmetric and varying precession of the polar atmospheric circulation with respect to the planetary axis.

  12. Polarized Light Microscopy

    Science.gov (United States)

    Frandsen, Athela F.

    2016-01-01

    Polarized light microscopy (PLM) is a technique which employs the use of polarizing filters to obtain substantial optical property information about the material which is being observed. This information can be combined with other microscopy techniques to confirm or elucidate the identity of an unknown material, determine whether a particular contaminant is present (as with asbestos analysis), or to provide important information that can be used to refine a manufacturing or chemical process. PLM was the major microscopy technique in use for identification of materials for nearly a century since its introduction in 1834 by William Fox Talbot, as other techniques such as SEM (Scanning Electron Microscopy), FTIR (Fourier Transform Infrared spectroscopy), XPD (X-ray Powder Diffraction), and TEM (Transmission Electron Microscopy) had not yet been developed. Today, it is still the only technique approved by the Environmental Protection Agency (EPA) for asbestos analysis, and is often the technique first applied for identification of unknown materials. PLM uses different configurations in order to determine different material properties. With each configuration additional clues can be gathered, leading to a conclusion of material identity. With no polarizing filter, the microscope can be used just as a stereo optical microscope, and view qualities such as morphology, size, and number of phases. With a single polarizing filter (single polars), additional properties can be established, such as pleochroism, individual refractive indices, and dispersion staining. With two polarizing filters (crossed polars), even more can be deduced: isotropy vs. anisotropy, extinction angle, birefringence/degree of birefringence, sign of elongation, and anomalous polarization colors, among others. With the use of PLM many of these properties can be determined in a matter of seconds, even for those who are not highly trained. McCrone, a leader in the field of polarized light microscopy, often

  13. Polarization transfer from polarized nuclear spin to μ- spin in muonic atom

    International Nuclear Information System (INIS)

    Kuno, Yoshitaka; Nagamine, Kanetada; Yamazaki, Toshimitsu.

    1987-02-01

    A theoretical study of polarization transfer from an initially-polarized nuclear spin to a μ - spin in a muonic atom is given. The switching of the hyperfine interaction at excited muonic states as well as at the ground 1s state is taken into account. The upper state of hyperfine doublet at the muonic 1s state is considered to proceed down to the lower state. It is found that as the hyperfine interaction becomes effective at higher excited muonic orbitals, a less extent of polarization is transferred from the nuclear spin to the μ - spin. The theoretical values obtained are compared with the recent experiment of μ - repolarization in a polarized 209 Bi target. (author)

  14. PolarTREC—A Model Program for Taking Polar Literacy into the Future

    Science.gov (United States)

    Warburton, J.; Timm, K.; Larson, A. M.

    2009-12-01

    Polar TREC—Teachers and Researchers Exploring and Collaborating, is a three-year (2007-2009) NSF-funded International Polar Year (IPY) teacher professional development program that advances Science, Technology, Engineering, and Mathematics (STEM) education by improving teacher content knowledge and instructional practices through Teacher Research Experiences (TRE) in the Arctic and Antarctic. Leveraging profound changes and fascinating science taking place in the polar regions, PolarTREC broadly disseminates activities and products to students, educators, researchers, and the public, connecting them with the Arctic and Antarctica and sustaining the widespread interest in the polar regions and building on the enthusiasm that was generated through IPY. Central to the PolarTREC Teacher Research Experience Model, over 40 teachers have spent two to eight weeks participating in hands-on research in the polar regions and sharing their experiences with diverse audiences via live events, online multimedia journals, and interactive bulletin boards. The Connecting Arctic/Antarctic Researchers and Educators (CARE) Network unifies learning community members participants, alumni, and others, developing a sustainable association of education professionals networking to share and apply polar STEM content and pedagogical skills. Educator and student feedback from preliminary results of the program evaluation has shown that PolarTREC’s comprehensive program activities have many positive impacts on educators and their ability to teach science concepts and improve their teaching methods. Additionally, K-12 students polled in interest surveys showed significant changes in key areas including amount of time spent in school exploring research activities, importance of understanding science for future work, importance of understanding the polar regions as a person in today’s world, as well as increased self-reported knowledge and interest in numerous science content areas. Building

  15. The evolution of tensor polarization

    International Nuclear Information System (INIS)

    Huang, H.; Lee, S.Y.; Ratner, L.

    1993-01-01

    By using the equation of motion for the vector polarization, the spin transfer matrix for spin tensor polarization, the spin transfer matrix for spin tensor polarization is derived. The evolution equation for the tensor polarization is studied in the presence of an isolate spin resonance and in the presence of a spin rotor, or snake

  16. Polar low monitoring

    Science.gov (United States)

    Bobylev, Leonid; Zabolotskikh, Elizaveta; Mitnik, Leonid

    2010-05-01

    Polar lows are intense mesoscale atmospheric low pressure weather systems, developing poleward of the main baroclinic zone and associated with high surface wind speeds. Small size and short lifetime, sparse in-situ observations in the regions of their development complicate polar low study. Our knowledge of polar lows and mesocyclones has come almost entirely during the period of satellite remote sensing since, by virtue of their small horizontal scale, it was rarely possible to analyse these lows on conventional weather charts using only the data from the synoptic observing network. However, the effects of intense polar lows have been felt by coastal communities and seafarers since the earliest times. These weather systems are thought to be responsible for the loss of many small vessels over the centuries, although the nature of the storms was not understood and their arrival could not be predicted. The actuality of the polar low research is stipulated by their high destructive power: they are a threat to such businesses as oil and gas exploration, fisheries and shipping. They could worsen because of global warming: a shrinking of sea ice around the North Pole, which thawed to its record minimum in the summer of 2007, is likely to give rise to more powerful storms that form only over open water and can cause hurricane-strength winds. Therefore, study of polar lows, their timely detection, tracking and forecasting represents a challenge for today meteorology. Satellite passive microwave data, starting from Special Sensor Microwave Imager (SSM/I) onboard Defense Meteorological Satellite Program (DMSP) satellite, remain invaluable source of regularly available remotely sensed data to study polar lows. The sounding in this spectral range has several advantages in comparison with observations in visible and infrared ranges and Synthetic Aperture Radar (SAR) data: independence on day time and clouds, regularity and high temporal resolution in Polar Regions. Satellite

  17. The Bochum Polarized Target

    International Nuclear Information System (INIS)

    Reicherz, G.; Goertz, S.; Harmsen, J.; Heckmann, J.; Meier, A.; Meyer, W.; Radtke, E.

    2001-01-01

    The Bochum 'Polarized Target' group develops the target material 6 LiD for the COMPASS experiment at CERN. Several different materials like alcohols, alcanes and ammonia are under investigation. Solid State Targets are polarized in magnetic fields higher than B=2.5T and at temperatures below T=1K. For the Dynamic Nuclear Polarization process, paramagnetic centers are induced chemically or by irradiation with ionizing beams. The radical density is a critical factor for optimization of polarization and relaxation times at adequate magnetic fields and temperatures. In a high sensitive EPR--apparatus, an evaporator and a dilution cryostat with a continuous wave NMR--system, the materials are investigated and optimized. To improve the polarization measurement, the Liverpool NMR-box is modified by exchanging the fixed capacitor for a varicap diode which not only makes the tuning very easy but also provides a continuously tuned circuit. The dependence of the signal area upon the circuit current is measured and it is shown that it follows a linear function

  18. C-reactive protein implications in new-onset hypertension in a healthy population initially aged 65 years : the Proof study

    NARCIS (Netherlands)

    Dauphinot, Virginie; Roche, Frederic; Kossovsky, Michel P.; Schott, Anne-Marie; Pichot, Vincent; Gaspoz, Jean-Michel; Gosse, Philippe; Barthelemy, Jean-Claude

    Background Because inflammation is known to be related with several cardiovascular diseases, we sought to determine whether C-reactive protein (CRP) might precede the onset of hypertension. Methods The study population was selected from the Proof study cohort including 1011 individuals initially

  19. The Early-Career Development of Science Teachers from Initial Training Onwards: The Advantages of a Multifaceted Five-Year Programme

    Science.gov (United States)

    Clarke, Julian; Howarth, Sue; King, Chris; Perry, John; Tas, Maarten; Twidle, John; Warhurst, Adrian; Garrett, Caro

    2014-01-01

    If a programme were to be devised for the early-career development of science teachers, what might such a programme look like? This was the focus of a meeting of science educators interested in developing such a structure, from the start of initial teacher training onwards. The contributions, modified and written up here, include a suggested…

  20. In-line Fiber Polarizer

    OpenAIRE

    Perumalsamy, Priya

    1998-01-01

    Polarizers and polarization devices are important components in fiber optic communication and sensor systems. There is a growing need for efficient low loss components that are compatible with optical fibers. An all fiber in-line polarizer is a more desirable alternative that could be placed at appropriate intervals along communication links. An in-line fiber polarizer was fabricated and tested. The in-line fiber polarizer operates by coupling optical energy propagatin...

  1. Political Competition and Polarization

    DEFF Research Database (Denmark)

    Schultz, Christian

    This paper considers political competition and the consequences of political polarization when parties are better informed about how the economy functions than voters are. Specifically, parties know the cost producing a public good, voters do not. An incumbent's choice of policy acts like a signa...... for costs before an upcoming election. It is shown that the more polarized the political parties the more distorted the incumbent's policy choice.......This paper considers political competition and the consequences of political polarization when parties are better informed about how the economy functions than voters are. Specifically, parties know the cost producing a public good, voters do not. An incumbent's choice of policy acts like a signal...

  2. No More Polarization, Please!

    DEFF Research Database (Denmark)

    Hansen, Mia Reinholt

    The organizational science literature on motivation has for long been polarized into two main positions; the organizational economic position focusing on extrinsic motivation and the organizational behavior position emphasizing intrinsic motivation. With the rise of the knowledge economy...... and the increasing levels of complexities it entails, such polarization is not fruitful in the attempt to explain motivation of organizational members. This paper claims that a more nuanced perspective on motivation, acknowledging the co-existence of intrinsic and extrinsic motivation, the possible interaction...... between the two as well as different types of motivations filling in the gap between the two polar types, is urgently needed in the organizational science literature. By drawing on the research on intrinsic and extrinsic motivation conducted in social psychology and combining this with contributions from...

  3. POLARIZED NEUTRONS IN RHIC

    Energy Technology Data Exchange (ETDEWEB)

    COURANT,E.D.

    1998-04-27

    There does not appear to be any obvious way to accelerate neutrons, polarized or otherwise, to high energies by themselves. To investigate the behavior of polarized neutrons the authors therefore have to obtain them by accelerating them as components of heavier nuclei, and then sorting out the contribution of the neutrons in the analysis of the reactions produced by the heavy ion beams. The best neutron carriers for this purpose are probably {sup 3}He nuclei and deuterons. A polarized deuteron is primarily a combination of a proton and a neutron with their spins pointing in the same direction; in the {sup 3}He nucleus the spins of the two protons are opposite and the net spin (and magnetic moment) is almost the same as that of a free neutron. Polarized ions other than protons may be accelerated, stored and collided in a ring such as RHIC provided the techniques proposed for polarized proton operation can be adapted (or replaced by other strategies) for these ions. To accelerate polarized particles in a ring, one must make provisions for overcoming the depolarizing resonances that occur at certain energies. These resonances arise when the spin tune (ratio of spin precession frequency to orbit frequency) resonates with a component present in the horizontal field. The horizontal field oscillates with the vertical motion of the particles (due to vertical focusing); its frequency spectrum is dominated by the vertical oscillation frequency and its modulation by the periodic structure of the accelerator ring. In addition, the magnet imperfections that distort the closed orbit vertically contain all integral Fourier harmonics of the orbit frequency.

  4. Polar Perspectives on Art and Science

    Science.gov (United States)

    Rennermalm, A. K.; Salzman, H.; Gustafson, D.

    2014-12-01

    The rapidly changing climate and environment in polar regions in the 20th and 21st centuries are well documented by scientists. Yet, this understanding is not well disseminated to students and the general public because the language of science is often inaccessible to these groups. To increase participation in science about the changing Polar regions, we organized a series of interdisciplinary events at Rutgers, The State University of New Jersey, in 2013/14 called "Polar Perspectives on Art and Science". This series brought five artist/scholars to Rutgers and reached a broad audience of students, faculty and the general public. Accompanying this series were two high-profile events. First, the Zimmerli Art Museum's academic-year-long exhibit, "Glacial Perspectives," displayed paintings and photographs by Diane Burko documenting rapidly changing glacial, and polar landscapes. Second, the "Let Us Talk About Water" event included a screening of the documentary "Chasing Ice" followed by a panel discussion at the Rutgers Cinema. Financial support was provided by Zimmerli Art Museum's Andrew W. Mellon Endowment Fund, Consortium of Universities for the Advancement of Hydrological Sciences, Inc., Rutgers Centers for Global Advancement and International Affairs, GAIA, and many other Rutgers institutes and departments. Student feedback on the "Polar Perspectives on Science and Art" suggest that art was effective in enhancing engagement and understanding of contemporary polar change. Furthermore, the many events created a forum for reoccurring and stimulating discussions among people with their academic home in widely different disciplines, including humanities, and physical and social sciences.

  5. Diurnal and seasonal occurrence of polar patches

    Directory of Open Access Journals (Sweden)

    A. S. Rodger

    1996-05-01

    Full Text Available Analysis of the diurnal and seasonal variation of polar patches, as identified in two years of HF-radar data from Halley, Antarctica during a period near sunspot maximum, shows that there is a broad maximum in occurrence centred about magnetic noon, not local noon. There are minima in occurrence near midsummer and midwinter, with maxima in occurrence between equinox and winter. There are no significant correlations between the occurrence of polar patches and the corresponding hourly averages of the solar wind and IMF parameters, except that patches usually occur when the interplanetary magnetic field has a southward component. The results can be understood in terms of UT and seasonal differences in the plasma concentration being convected from the dayside ionosphere into the polar cap. In summer and winter the electron concentrations in the polar cap are high and low, respectively, but relatively unstructured. About equinox, a tongue of enhanced ionisation is convected into the polar cap; this tongue is then structured by the effects of the interplanetary magnetic field, but these Halley data cannot be used to separate the various competing mechanisms for patch formation. The observed diurnal and seasonal variation in the occurrence of polar patches are largely consistent with predictions of Sojka et al. (1994 when their results are translated into the southern hemisphere. However, the ionospheric effects of flux transfer events are still considered essential in their formation, a feature not yet included in the Sojka et al. model.

  6. Polarized neutrons for Australian scientific research

    International Nuclear Information System (INIS)

    Kennedy, Shane J.

    2005-01-01

    Polarized neutron scattering has been a feature at ANSTO's HIFAR research reactor since the first polarization analysis (PA) spectrometer Longpol began operation over 30 years ago. Since that time, we have improved performance of Longpol and added new capabilities in several reincarnations of the instrument. Most of the polarized neutron experiments have been in the fields of magnetism and superconductivity, and most of that research has involved PA. Now as we plan our next generation neutron beam facility, at the Replacement Research Reactor (RRR), we intend to continue the tradition of PA but with a far broader scope in mind. Our new capabilities will combine PA and energy analysis with both cold and thermal neutron source spectra. We will also provide capabilities for research with polarized neutrons in small-angle neutron scattering and in neutron reflectometry. The discussion includes a brief historical account of the technical developments with a summary of past and present applications of polarized neutrons at HIFAR, and an outline of the polarized neutron capabilities that will be included in the first suite of instruments, which will begin operation at the new reactor in 2006

  7. Dark Polar Dunes

    Science.gov (United States)

    2005-01-01

    20 January 2004 This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image, acquired during northern summer in December 2004, shows dark, windblown sand dunes in the north polar region of Mars. A vast sea of sand dunes nearly surrounds the north polar cap. These landforms are located near 80.3oN, 144.1oW. Light-toned features in the image are exposures of the substrate that underlies the dune field. The image covers an area about 3 km (1.9 mi) wide and is illuminated by sunlight from the lower left.

  8. Imaging with Polarized Neutrons

    Directory of Open Access Journals (Sweden)

    Nikolay Kardjilov

    2018-01-01

    Full Text Available Owing to their zero charge, neutrons are able to pass through thick layers of matter (typically several centimeters while being sensitive to magnetic fields due to their intrinsic magnetic moment. Therefore, in addition to the conventional attenuation contrast image, the magnetic field inside and around a sample can be visualized by detecting changes of polarization in a transmitted beam. The method is based on the spatially resolved measurement of the cumulative precession angles of a collimated, polarized, monochromatic neutron beam that traverses a magnetic field or sample.

  9. Internal polarized targets

    Energy Technology Data Exchange (ETDEWEB)

    Kinney, E.R.; Coulter, K.; Gilman, R.; Holt, R.J.; Kowalczyk, R.S.; Napolitano, J.; Potterveld, D.H.; Young, L. (Argonne National Lab., IL (USA)); Mishnev, S.I.; Nikolenko, D.M.; Popov, S.G.; Rachek, I.A.; Temnykh, A.B.; Toporkov, D.K.; Tsentalovich, E.P.; Wojtsekhowski, B.B. (AN SSSR, Novosibirsk (USSR). Inst. Yadernoj Fiziki)

    1989-01-01

    Internal polarized targets offer a number of advantages over external targets. After a brief review of the basic motivation and principles behind internal polarized targets, the technical aspects of the atomic storage cell will be discussed in particular. Sources of depolarization and the means by which their effects can be ameliorated will be described, especially depolarization by the intense magnetic fields arising from the circulating particle beam. The experience of the Argonne Novosibirsk collaboration with the use of a storage cell in a 2 GeV electron storage ring will be the focus of this technical discussion. 17 refs., 11 figs.

  10. AGS polarized H- source

    International Nuclear Information System (INIS)

    Kponou, A.; Alessi, J.G.; Sluyters, T.

    1985-01-01

    The AGS polarized H - source is now operational. During a month-long experimental physics run in July 1984, pulses equivalent to 15 μA x 300 μs (approx. 3 x 10 10 protons) were injected into the RFQ preaccelerator. Beam polarization, measured at 200 MeV, was approx. 75%. After the run, a program to increase the H - yield of the source was begun and significant progress has been made. The H - current is now frequently 20 to 30 μA. A description of the source and some details of our operating experience are given. We also briefly describe the improvement program

  11. Polarized fuel for controlled thermonuclear fusion

    Science.gov (United States)

    Bartalucci, Sergio

    2017-07-01

    The use of polarized nuclei as a fuel for thermonuclear fusion reactors was suggested more than 30 years ago, providing evidence for a significant increase of the total cross section. In particular, an enhancement factor close to 1.5 is expected in the energy range below 100 keV for the dominant nuclear fusion reactions 2H + 3H → 4He + n + 17.58 MeV and 2H + 3He → 4He + p + 18.34 MeV. Furthermore, the use of polarized fuel allows one to control the ejectile trajectories, via an enhancement in the forward-backward cross section asymmetry due to polarization. This allows some control on the energy transfer from the plasma to the reactor wall or helps concentrate the neutron flux to defined wall areas. Nevertheless, this idea was received with skepticism by the relevant scientific community, due to some uncertainty in the physics of the process, the low efficiency in the production of polarized beams for injection into plasma and the apparent difficulty of preserving the ion polarization for a time long compared with nuclear burning time. But more recently, as a consequence of significant progress in the field of atomic beam sources and polarized targets, the interest in this matter has been refreshed for both inertially and magnetically confined plasmas. The possibility of implementing nuclear polarization in present and future fusion reactors is discussed in this paper. In particular, the interaction between polarized ions and magnetic fields, both static and RF, which are typically used in a Tokamak for plasma heating via ion cyclotron resonance (ICRH), is considered. Also, experimental issues for practically performing a feasibility test on a real fusion reactors are illustrated.

  12. Unpolarized nucleon structure studies utilizing polarized electromagnetic probes

    International Nuclear Information System (INIS)

    Arrington, J.

    2009-01-01

    By the mid-1980s, measurements of the nucleon form factors had reached a stage where only slow, incremental progress was possible using unpolarized electron scattering. The development of high quality polarized beams, polarized targets, and recoil polarimeters led to a renaissance in the experimental program. I provide an overview of the changes in the field in the last ten years, which were driven by the dramatically improved data made possible by a new family of tools to measure polarization observables

  13. QSAT: The Satellite for Polar Plasma Observation

    Science.gov (United States)

    Tsuruda, Yoshihiro; Fujimoto, Akiko; Kurahara, Naomi; Hanada, Toshiya; Yumoto, Kiyohumi; Cho, Mengu

    2009-04-01

    This paper introduces QSAT, the satellite for polar plasma observation. The QSAT project began in 2006 as an initiative by graduate students of Kyushu University, and has the potential to contribute greatly to IHY (International Heliophysical Year) by showing to the world the beauty, importance, and relevance of space science. The primary objectives of the QSAT mission are (1) to investigate plasma physics in the Earth’s aurora zone in order to better understand spacecraft charging, and (2) to conduct a comparison of the field-aligned current observed in orbit with ground-based observations. The QSAT project can provide education and research opportunities for students in an activity combining space sciences and satellite engineering. The QSAT satellite is designed to be launched in a piggyback fashion with the Japanese launch vehicle H-IIA. The spacecraft bus is being developed at the Department of Aeronautics and Astronautics of Kyushu University with collaboration of Fukuoka Institute of Technology. Regarding the payload instruments, the Space Environment Research Center of Kyushu University is developing the magnetometers, whereas the Laboratory of Spacecraft Environment Interaction Engineering of Kyushu Institute of Technology is developing the plasma probes. We aim to be ready for launch in 2009 or later.

  14. The physics of polarization

    Science.gov (United States)

    Landi Degl'Innocenti, Egidio

    This course is intended to give a description of the basic physical concepts which underlie the study and the interpretation of polarization phenomena. Apart from a brief historical introduction (Sect. 1), the course is organized in three parts. A first part (Sects. 2 - 6) covers the most relevant facts about the polarization phenomena that are typically encountered in laboratory applications and in everyday life. In Sect. 2, the modern description of polarization in terms of the Stokes parameters is recalled, whereas Sect. 3 is devoted to introduce the basic tools of laboratory polarimetry, such as the Jones calculus and the Mueller matrices. The polarization phenomena which are met in the reflection and refraction of a beam of radiation at the separation surface between two dielectrics, or between a dielectric and a metal, are recalled in Sect. 4. Finally, Sect. 5 gives an introduction to the phenomena of dichroism and of anomalous dispersion and Sect. 6 summarizes the polarization phenomena that are commonly encountered in everyday life. The second part of this course (Sects. 7-14) deals with the description, within the formalism of classical physics, of the spectro-polarimetric properties of the radiation emitted by accelerated charges. Such properties are derived by taking as starting point the Liénard and Wiechert equations that are recalled and discussed in Sect. 7 both in the general case and in the non-relativistic approximation. The results are developed to find the percentage polarization, the radiation diagram, the cross-section and the spectral characteristics of the radiation emitted in different phenomena particularly relevant from the astrophysical point of view. The emission of a linear antenna is derived in Sect. 8. The other Sections are devoted to Thomson scattering (Sect. 9), Rayleigh scattering (Sect. 10), Mie scattering (Sect. 11), bremsstrahlung radiation (Sect. 12), cyclotron radiation (Sect. 13), and synchrotron radiation (Sect. 14

  15. Polarized Proton Collisions at RHIC

    CERN Document Server

    Bai, Mei; Alekseev, Igor G; Alessi, James; Beebe-Wang, Joanne; Blaskiewicz, Michael; Bravar, Alessandro; Brennan, Joseph M; Bruno, Donald; Bunce, Gerry; Butler, John J; Cameron, Peter; Connolly, Roger; De Long, Joseph; Drees, Angelika; Fischer, Wolfram; Ganetis, George; Gardner, Chris J; Glenn, Joseph; Hayes, Thomas; Hseuh Hsiao Chaun; Huang, Haixin; Ingrassia, Peter; Iriso, Ubaldo; Laster, Jonathan S; Lee, Roger C; Luccio, Alfredo U; Luo, Yun; MacKay, William W; Makdisi, Yousef; Marr, Gregory J; Marusic, Al; McIntyre, Gary; Michnoff, Robert; Montag, Christoph; Morris, John; Nicoletti, Tony; Oddo, Peter; Oerter, Brian; Osamu, Jinnouchi; Pilat, Fulvia Caterina; Ptitsyn, Vadim; Roser, Thomas; Satogata, Todd; Smith, Kevin T; Svirida, Dima; Tepikian, Steven; Tomas, Rogelio; Trbojevic, Dejan; Tsoupas, Nicholaos; Tuozzolo, Joseph; Vetter, Kurt; Wilinski, Michelle; Zaltsman, Alex; Zelenski, Anatoli; Zeno, Keith; Zhang, S Y

    2005-01-01

    The Relativistic Heavy Ion Collider~(RHIC) provides not only collisions of ions but also collisions of polarized protons. In a circular accelerator, the polarization of polarized proton beam can be partially or fully lost when a spin depolarizing resonance is encountered. To preserve the beam polarization during acceleration, two full Siberian snakes were employed in RHIC to avoid depolarizing resonances. In 2003, polarized proton beams were accelerated to 100~GeV and collided in RHIC. Beams were brought into collisions with longitudinal polarization at the experiments STAR and PHENIX by using spin rotators. RHIC polarized proton run experience demonstrates that optimizing polarization transmission efficiency and improving luminosity performance are significant challenges. Currently, the luminosity lifetime in RHIC is limited by the beam-beam effect. The current state of RHIC polarized proton program, including its dedicated physics run in 2005 and efforts to optimize luminosity production in beam-beam limite...

  16. Polarized seismic and solitary waves run-up at the sea bed

    Energy Technology Data Exchange (ETDEWEB)

    Dennis, L. C.C.; Zainal, A. A.; Faisal, S. Y. [Universiti Teknologi PETRONAS, 31750 Tronoh, Perak (Malaysia); Universiti Teknologi Malaysia, 81310 Johor Bahru (Malaysia)

    2012-09-26

    The polarization effects in hydrodynamics are studied. Hydrodynamic equation for the nonlinear wave is used along with the polarized solitary waves and seismic waves act as initial waves. The model is then solved by Fourier spectral and Runge-Kutta 4 methods, and the surface plot is drawn. The output demonstrates the inundation behaviors. Consequently, the polarized seismic waves along with the polarized solitary waves tend to generate dissimilar inundation which is more disastrous.

  17. Emergence and Dynamics of Polar Order in Developing Epithelia

    Science.gov (United States)

    Farhadifar, Reza

    2011-03-01

    Planar Cell Polarity (PCP) is a conserved process in many vertebrate and invertebrate tissues, and is fundamental for the coordination of cell behavior and patterning. A well-studied example is the orientational pattern of hairs in the wing of the adult fruit fly Drosophila, which is an important model organism in biology. The Drosophila wing is an epithelium, i.e., a two-dimensional sheet of cells, which grows from a few cells to thousands of cells during the course of development. In the wing epithelium, planar polarity is established by an anisotropic distribution of PCP proteins within cells. The distribution of these proteins in a given cell affects the polarity of neighboring cells, such that at the end of wing development a large-scale PCP orientational order emerges. Here we present a theoretical study of planar polarity in developing epithelia based on a vertex model, which takes into account cell mechanics, cell adhesion, and cell division, combined with experimental results obtained from time-lapse imaging of the wing development. We show that in experiment, polarity order does not develop de novo at the end of wing development, but rather cells are initially polarized at an angle with respect to their final polarity axis. During wing development, the polarity axes of cells reorient towards their final direction. We identify a basic mechanism to generate such a large-scale initial polarization, based on the growth of a small number of cells with an initially random PCP distribution. Finally, we study the effect of shear and oriented cell division on dynamics of PCP order, showing that these two processes can robustly reorient the polarity axes of cells.

  18. Polarized lepton-nucleon scattering

    Energy Technology Data Exchange (ETDEWEB)

    Hughes, E. [Stanford Univ., CA (United States)

    1994-12-01

    The author provides a summary of the proposed and published statistical (systematic) uncertainties from the world experiments on nucleon spin structure function integrals. By the time these programs are complete, there will be a vast resource of data on nucleon spin structure functions. Each program has quite different experimental approaches regarding the beams, targets, and spectrometers thus ensuring systematically independent tests of the spin structure function measurements. Since the field of spin structure function measurements began, there has been a result appearing approximately every five years. With advances in polarized target technology and high polarization in virtually all of the lepton beams, results are now coming out each year; this is a true signature of the growth in the field. Hopefully, the experiments will provide a consistent picture of nucleon spin structure at their completion. In summary, there are still many open questions regarding the internal spin structure of the nucleon. Tests of QCD via the investigation of the Bjorken sum rule is a prime motivator for the field, and will continue with the next round of precision experiments. The question of the origin of spin is still a fundamental problem. Researchers hope is that high-energy probes using spin will shed light on this intriguing mystery, in addition to characterizing the spin structure of the nucleon.

  19. Influence of initial vaccination with 13-valent pneumococcal conjugate vaccine or 23-valent pneumococcal polysaccharide vaccine on anti-pneumococcal responses following subsequent pneumococcal vaccination in adults 50 years and older.

    Science.gov (United States)

    Jackson, Lisa A; Gurtman, Alejandra; van Cleeff, Martin; Frenck, Robert W; Treanor, John; Jansen, Kathrin U; Scott, Daniel A; Emini, Emilio A; Gruber, William C; Schmoele-Thoma, Beate

    2013-08-02

    Unlike free polysaccharide vaccines, pneumococcal polysaccharide conjugate vaccines (PCVs) induce a T cell-dependent immune response and have the potential to provide an extended duration of protection with repeated vaccinations. This was an extension of a previous study in pneumococcal vaccine-naïve adults aged 50-64 years in which adults 60-64 years of age were given 13-valent PCV (PCV13) or 23-valent pneumococcal polysaccharide vaccine (PPSV23) and adults aged 50-59 were given PCV13. In this follow up study conducted about 4 years later, the 60-64 year olds initially given PCV13 received PCV13 or PPSV23, and those initially given PPSV23 received another PPSV23. All adults aged 50-59 years were re-vaccinated with PCV13. Anti-pneumococcal opsonophagocytic activity (OPA) titers were measured before and 1 month after vaccination. A second PCV13 given about 4 years after a first vaccination induced OPA titers that were significantly higher than those following the initial vaccination for 7 of 13 serotypes in the older group, and 6 of 13 serotypes in the younger group, and responses to the remaining serotypes were largely non-inferior. In contrast, OPA titers following revaccination with PPSV23 were statistically significantly lower for 9 of the 13 serotypes, and non-inferior for the remaining serotypes, when compared to the responses to the first PPSV23. OPA titers in the older adults who received PPSV23 after initial PCV13 were significantly higher than those following a first PPSV23 for 10 of the 13 serotypes. In adults 50 to 64 years of age, initial vaccination with PCV13 establishes an immune state that results in recall anti-pneumococcal responses upon subsequent vaccination with either conjugated or free polysaccharide vaccine. In contrast, initial vaccination with PPSV23 results in an immune state in which subsequent PPSV23 administration yields generally lower responses compared with the initial responses. Copyright © 2013 The Authors. Published by Elsevier

  20. Lobbying and political polarization

    OpenAIRE

    Ursprung, Heinrich W.

    2002-01-01

    Standard spatial models of political competition give rise to equilibria in which the competing political parties or candidates converge to a common position. In this paper I show how political polarization can be generated in models that focus on the nexus between pre-election interest group lobbying and electoral competition.

  1. Fluorescence confocal polarizing microscopy

    Indian Academy of Sciences (India)

    Much of the modern understanding of orientational order in liquid crystals (LCs) is based on polarizing microscopy (PM). A PM image bears only two-dimensional (2D) information, integrating the 3D pattern of optical birefringence over the path of light. Recently, we proposed a technique to image 3D director patterns by ...

  2. Polarization of Bremsstrahlung

    International Nuclear Information System (INIS)

    Miller, J.

    1957-01-01

    The numerical results for the polarization of Bremsstrahlung are presented. The multiple scattering of electrons in the target is taken into account. The angular-and photon energy dependences are seen on the curves for an incident 25 MeV electron energy. (Author) [fr

  3. Titan Polar Landscape Evolution

    Science.gov (United States)

    Moore, Jeffrey M.

    2016-01-01

    With the ongoing Cassini-era observations and studies of Titan it is clear that the intensity and distribution of surface processes (particularly fluvial erosion by methane and Aeolian transport) has changed through time. Currently however, alternate hypotheses substantially differ among specific scenarios with respect to the effects of atmospheric evolution, seasonal changes, and endogenic processes. We have studied the evolution of Titan's polar region through a combination of analysis of imaging, elevation data, and geomorphic mapping, spatially explicit simulations of landform evolution, and quantitative comparison of the simulated landscapes with corresponding Titan morphology. We have quantitatively evaluated alternate scenarios for the landform evolution of Titan's polar terrain. The investigations have been guided by recent geomorphic mapping and topographic characterization of the polar regions that are used to frame hypotheses of process interactions, which have been evaluated using simulation modeling. Topographic information about Titan's polar region is be based on SAR-Topography and altimetry archived on PDS, SAR-based stereo radar-grammetry, radar-sounding lake depth measurements, and superposition relationships between geomorphologic map units, which we will use to create a generalized topographic map.

  4. Graphics of polar figure

    International Nuclear Information System (INIS)

    Macias B, L.R.

    1991-11-01

    The objective of this work, is that starting from a data file coming from a spectra that has been softened, and of the one that have been generated its coordinates to project it in stereographic form, to create the corresponding polar figure making use of the Cyber computer of the ININ by means of the GRAPHOS package. This work only requires a Beta, Fi and Intensity (I) enter data file. It starts of the existence of a softened spectra of which have been generated already with these data, making use of some language that in this case was FORTRAN for the Cyber computer, a program is generated supported in the Graphos package that allows starting of a reading of the Beta, Fi, I file, to generate the points in a stereographic projection and that it culminates with the graph of the corresponding polar figure. The program will request the pertinent information that is wanted to capture in the polar figure just as: date, name of the enter file, indexes of the polar figure, number of levels, radio of the stereographic projection (cms.), crystalline system to which belongs the sample, name the neuter graph file by create and to add the own general data. (Author)

  5. Characteristics of volume polarization holography with linear polarization light

    Science.gov (United States)

    Zang, Jinliang; Wu, An'an; Liu, Ying; Wang, Jue; Lin, Xiao; Tan, Xiaodi; Shimura, Tsutomu; Kuroda, Kazuo

    2015-10-01

    Volume polarization holographic recording in phenanthrenequinone-doped poly(methyl methacrylate) (PQ-PMMA) photopolymer with linear polarized light is obtained. The characteristics of the volume polarization hologram are experimentally investigated. It is found that beyond the paraxial approximation the polarization states of the holographic reconstruction light are generally different from the signal light. Based on vector wave theoretical analyses and material properties, the special exposure condition for correctly holographic reconstruction is obtained and experimentally demonstrated.

  6. Decreased use of glucocorticoids in biological-experienced patients with rheumatoid arthritis who initiated intravenous abatacept: results from the 2-year ACTION study

    Science.gov (United States)

    Alten, Rieke; Nüßlein, Hubert; Galeazzi, Mauro; Lorenz, Hanns-Martin; Nurmohamed, Michael T; Bensen, William G; Burmester, Gerd R; Peter, Hans-Hartmut; Pavelka, Karel; Chartier, Mélanie; Poncet, Coralie; Rauch, Christiane; Elbez, Yedid; Le Bars, Manuela

    2016-01-01

    Introduction Prolonged glucocorticoid use may increase the risk of adverse safety outcomes, including cardiovascular events. The European League Against Rheumatism and the Canadian Rheumatology Association advise tapering glucocorticoid dose as rapidly as clinically feasible. There is a paucity of published data on RA that adequately describe concomitant treatment patterns. Methods ACTION (AbataCepT In rOutiNe clinical practice) is a non-interventional cohort study of patients from Europe and Canada that investigated the long-term retention of intravenous abatacept in clinical practice. We assessed concomitant glucocorticoids in patients with established RA who had participated in ACTION and received ≥1 biological agent prior to abatacept initiation. Results The analysis included 1009 patients. Glucocorticoids were prescribed at abatacept initiation in 734 (72.7%) patients at a median 7.5 mg/day dose (n=692). Of the patients who remained on abatacept at 24 months, 40.7% were able to decrease their dose of glucocorticoids, including 26.9% who decreased their dose from >5 mg/day to ≤5 mg/day. Conclusion Reduction and/or cessation of glucocorticoid therapy is possible with intravenous abatacept in clinical practice. PMID:26925253

  7. Manufacturing Initiative

    Data.gov (United States)

    National Aeronautics and Space Administration — The Advanced Manufacturing Technologies (AMT) Project supports multiple activities within the Administration's National Manufacturing Initiative. A key component of...

  8. Experiments with Fermilab polarized proton and polarized antiproton beams

    International Nuclear Information System (INIS)

    Yokosawa, A.

    1990-01-01

    We summarize activities concerning the Fermilab polarized beams. They include a brief description of the polarized-beam facility, measurements of beam polarization by polarimeters, asymmetry measurements in the π degree production at high p perpendicular and in the Λ (Σ degree), π ± , π degree production at large x F , and Δσ L (pp, bar pp) measurements. 18 refs

  9. NUCLEON POLARIZATION IN 3-BODY MODELS OF POLARIZED LI-6

    NARCIS (Netherlands)

    SCHELLINGERHOUT, NW; KOK, LP; COON, SA; ADAM, RM

    1993-01-01

    Just as He-3 --> can be approximately characterized as a polarized neutron target, polarized Li-6D has been advocated as a good isoscalar nuclear target for the extraction of the polarized gluon content of the nucleon. The original argument rests upon a presumed ''alpha + deuteron'' picture of Li-6,

  10. Proceedings of the workshop on polarized targets in storage rings

    International Nuclear Information System (INIS)

    Holt, R.J.

    1984-08-01

    Polarization phenomena have played an increasingly important part in the study of nuclei and nucleons in recent years. Polarization studies have been hampered by the relatively few and rather fragile polarized targets which are presently available. The concept of polarized gas targets in storage rings opens a much wider range of possibilities than is available in the external target geometry. This novel method will represent a considerable advance in nuclear physics and will continue to receive much attention in plans for future facilities. An internal, polarized-target station is being planned for the cooler ring at the Indiana University Cyclotron Facility. Internal targets are compatible with recent designs of electron accelerators proposed by the Massachusetts Institute of Technology and the Southeastern Universities Research Association. The key to nuclear-science programs based on internal targets pivots on recent developments in polarized atomic beam methods, which include the more recent laser-driven polarized targets. The workshop drew together a unique group of physicists in the fields of high-energy, nuclear and atomic physics. The meeting was organized in a manner that stimulated discussion among the 58 participants and focused on developments in polarized target technology and the underlying atomic physics. An impressive array of future possibilities for polarized targets as well as current developments in polarized target technology were discussed at the workshop. Abstracts of individual items from the workshop were prepared separately for the data base

  11. Proceedings of the workshop on polarized targets in storage rings

    Energy Technology Data Exchange (ETDEWEB)

    Holt, R.J. (ed.)

    1984-08-01

    Polarization phenomena have played an increasingly important part in the study of nuclei and nucleons in recent years. Polarization studies have been hampered by the relatively few and rather fragile polarized targets which are presently available. The concept of polarized gas targets in storage rings opens a much wider range of possibilities than is available in the external target geometry. This novel method will represent a considerable advance in nuclear physics and will continue to receive much attention in plans for future facilities. An internal, polarized-target station is being planned for the cooler ring at the Indiana University Cyclotron Facility. Internal targets are compatible with recent designs of electron accelerators proposed by the Massachusetts Institute of Technology and the Southeastern Universities Research Association. The key to nuclear-science programs based on internal targets pivots on recent developments in polarized atomic beam methods, which include the more recent laser-driven polarized targets. The workshop drew together a unique group of physicists in the fields of high-energy, nuclear and atomic physics. The meeting was organized in a manner that stimulated discussion among the 58 participants and focused on developments in polarized target technology and the underlying atomic physics. An impressive array of future possibilities for polarized targets as well as current developments in polarized target technology were discussed at the workshop. Abstracts of individual items from the workshop were prepared separately for the data base.

  12. On the large COMPASS polarized deuteron target

    Czech Academy of Sciences Publication Activity Database

    Ball, J.; Baum, G.; Doshita, N.; Finger Jr., M.; Finger, M.; Gautheron, F.; Goertz, S.; Hasegawa, T.; Heckmann, J.; Hess, C.; Horikawa, N.; Ishimoto, S.; Iwata, T.; Kisselev, Y.; Koivuniemi, J.H.; Kondo, K.; Le Goff, J.M.; Magnon, A.; Marchand, C.; Matsuda, T.; Meyer, W.; Reicherz, G.; Srnka, Aleš

    2006-01-01

    Roč. 56, Suppl. F (2006), F295-F305 ISSN 0011-4626 R&D Projects: GA MŠk ME 492 Institutional research plan: CEZ:AV0Z20650511 Keywords : COMPASS * polarized target * Dilution refrigerator Subject RIV: BF - Elementary Particles and High Energy Physics Impact factor: 0.568, year: 2006

  13. Grazing incidence polarized neutron scattering in reflection ...

    Indian Academy of Sciences (India)

    During the year 1980, polarized neutron scattering technique came into being as an ana- lytic tool to measure the ... The discovery of antiferromagnetic coupling was critical to the discovery of GMR, pro- viding as it did ..... Here we consider the incident wave vector ki making an angle αi in the x–z plane while the scattered ...

  14. Polarity of wurtzite crystals by photoelectron diffraction

    Czech Academy of Sciences Publication Activity Database

    Bartoš, Igor; Romanyuk, Olexandr

    2014-01-01

    Roč. 315, OCT (2014), s. 506-509 ISSN 0169-4332 Grant - others:AVČR(CZ) M100101201 Institutional support: RVO:68378271 Keywords : wurtzite semiconductors * surface polarity * X-ray photoelectron diffraction * XPD Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 2.711, year: 2014 http://www.sciencedirect.com/science/article/pii/S016943321400066X

  15. Coccolithophorids in polar waters: Wigwamma spp. revisited

    DEFF Research Database (Denmark)

    Thomsen, Helge Abildhauge; Østergaard, Jette B.; Heldal, Mikal

    2013-01-01

    A contingent of weakly calcified coccolithophorid genera and species were described from polar regions almost 40 years ago. In the interim period a few additional findings have been reported enlarging the realm of some of the species. The genus Wigwamma is revisited here with the purpose of provi...... appearance of the coccolith armour of the cell...

  16. Plasmaspheric hiss properties: Observations from Polar

    Czech Academy of Sciences Publication Activity Database

    Tsurutani, B. T.; Falkowski, B. J.; Pickett, J. S.; Santolík, Ondřej; Lakhina, G. S.

    2015-01-01

    Roč. 120, č. 1 (2015), s. 414-431 ISSN 2169-9380 R&D Projects: GA ČR GAP205/10/2279 Institutional support: RVO:68378289 Keywords : plasmasphere * hiss * Polar Subject RIV: BL - Plasma and Gas Discharge Physics Impact factor: 3.318, year: 2015 http://onlinelibrary.wiley.com/doi/10.1002/2014JA020518/abstract

  17. Polarized electron beams at SLAC

    International Nuclear Information System (INIS)

    Moffeit, K.C.

    1992-11-01

    SLAC has successfully accelerated high energy polarized electrons for the Stanford Linear Collider and fixed polarized nuclear target experiments. The polarized electron beams at SLAC use a gallium arsenide (GaAlAs for E-142) photon emission source to provide the beam of polarized electrons with polarization of approximately 28% (41% for E-142). While the beam emittance is reduced in the damping ring for SLC operation a system of bend magnets and superconducting solenoids preserve and orient the spin direction for maximum longitudinal polarization at the collision point. The electron polarization is monitored with a Compton scattering polarimeter, and was typically 22% at the e+e- collision point for the 1992 run. Improvements are discussed to increase the source polarization and to reduce the depolarization effects between the source and the collision point

  18. Analytical polarization calculations beyond SLIM

    International Nuclear Information System (INIS)

    Barber, D.P.

    1989-01-01

    A comparison is made between the theories of Bell and Leinaas and of Derbenev and Kondratenko for the spin polarization in electron storage rings. A calculation of polarization in HERA using the program SMILE of Mane is presented

  19. Site-directed subsurface environmental initiative: Five year summary and plan for fundamental research in subsoils and in groundwater, FY 1989-FY 1993

    International Nuclear Information System (INIS)

    1987-10-01

    The overall goal of this research initiative is to develop the necessary scientific basis for resolution of key technical obstacles to defining and remediating contamination at DOE and other waste sites. To accomplish this goal, the resouces of the national laboratories, universities, and DOE sites will be fully utilized to develop and demonstrate improved, cost-effective, and environmentally acceptable techniques for predicting the behavior of contaminants and reducing their concentrations in ground water. This document is a preliminary plan to set general research directions for a program extending into the 1990s. The needs and milestones identified in this plan may change with additional guidance from DOE sites. Promising research opportunities will be identified as part of national laboratory submissions of preliminary proposals

  20. Social Marketing as a Framework for Youth Physical Activity Initiatives: a 10-Year Retrospective on the Legacy of CDC's VERB Campaign.

    Science.gov (United States)

    Huhman, Marian; Kelly, Ryan P; Edgar, Timothy

    2017-06-01

    In 2002, the U.S. Centers for Disease Control and Prevention (CDC) launched the VERB. It's what you do! campaign to increase physical activity among tweens and concomitantly respond to the rise in childhood obesity. This retrospective study summarizes the history of the VERB campaign's social marketing approach and its effectiveness in promoting behavior change in the targeted population. The legacy of VERB, which ended in 2006, is discussed, with an emphasis on examining initiatives over the last decade and the degree to which they followed (or did not follow) the structural and thematic lead of the campaign. The article ends with suggestions for how VERB still has the potential to inform other social marketing campaigns going forward.

  1. Humor and College Adjustment: The Predictive Nature of Humor, Academic Achievement, Authoritative Parenting Styles on the Initial Adjustment of Male and Female First-Year College Students

    Science.gov (United States)

    Hickman, Gregory P.; Andrews, David W.

    2003-01-01

    A self-report questionnaire on academic achievement, birth order, and family structure; the Student Adaptation to College Questionnaire; the Parental Authority Questionnaire; and the Coping Humor Scale were administered to 257 first-year college students. Researchers examined the relationships among (a) authoritative parenting style, (b) family…

  2. Renal Branch Artery Occlusion in a 13-Year-Old Hypertensive Girl: Initial Treatment and Treatment of Recurrent Stenosis by Balloon Angioplasty

    International Nuclear Information System (INIS)

    Konez, Orhan; Burrows, Patricia E.; Harmon, William E.

    2001-01-01

    A 13-year-old girl who recently developed hypertension was diagnosed to have an occluded right renal branch artery and was treated successfully with percutaneous transluminal angioplasty (PTA). To our knowledge, PTA has not been reported as a treatment for totally occluded renal branch arteries, and there is no data available regarding the success rate and possible complications

  3. Ionization in elliptically polarized pulses: Multielectron polarization effects and asymmetry of photoelectron momentum distributions

    DEFF Research Database (Denmark)

    Shvetsov-Shilovskiy, Nikolay; Dimitrovski, Darko; Madsen, Lars Bojer

    2012-01-01

    In the tunneling regime we present a semiclassical model of above-threshold ionization with inclusion of the Stark shift of the initial state, the Coulomb potential, and a polarization induced dipole potential. The model is used for the investigation of the photoelectron momentum distributions...... in close to circularly polarized light, and it is validated by comparison with ab initio results and experiments. The momentum distributions are shown to be highly sensitive to the tunneling exit point, the Coulomb force, and the dipole potential from the induced dipole in the atomic core...

  4. On Determinants of Political Polarization

    OpenAIRE

    Grechyna, Daryna

    2015-01-01

    Political polarization has been shown to significantly influence a country's economic performance. However, little is known about the drivers of political polarization. In this article, we aim to identify the main determinants of political polarization using Bayesian Model Averaging to overcome the problem of model uncertainty. We find that the level of trust within a country and the degree of income inequality are the most robust determinants of political polarization.

  5. An assessment of ten ocean reanalyses in the polar regions

    Science.gov (United States)

    Uotila, Petteri

    2017-04-01

    Ocean reanalysis (ORA) combines observations either statistically or with a hydrodynamical model, to reconstruct historical changes in the ocean. Global and regional ORA products are increasingly used in polar research, but their quality remains to be systematically assessed. To address this, the Polar ORA Intercomparison Project (PORA-IP) has been established following on from the ORA-IP project (Balmaseda et al. 2015, with other papers in a special issue of Climate Dynamics). The PORA-IP is constituted under the COST EOS initiative with plans to review reanalyses products in both the Arctic and Antarctic, and is endorsed by YOPP - the Year of Polar Prediction project. Currently, the PORA-IP team consists of 21 researchers from 15 institutes and universities. The ORA-IP products with polar physics, such as sea ice, have been updated where necessary and collected in a public database. In addition to model output, available observational polar climatologies are collected and used in the assessments. Due to the extensive variety of products, this database should become a valuable resource outside the PORA-IP community. For a comprehensive evaluation of the ten ORA products (CGLORSv5, ECDA3.1, GECCO2, Glorys2v4, GloSea5_GO5, MOVEG2i, ORAP5, SODA3.3.1, TOPAZ4 and UR025.4) in the Arctic and Southern Oceans several specific diagnostics are assessed. The PORA-IP diagnostics target the following topics: hydrography; heat, salinity and freshwater content; ocean transports and surface currents; mixed layer depth; sea-ice concentration and thickness; and snow thickness over sea ice. Based on these diagnostics, ORA product biases against observed data and their mutual spread are quantified, and possible reasons for discrepancies discussed. So far, we have identified product outliers and evaluated the multi-model mean. We have identified the importance of the atmospheric forcing, air-ocean coupling protocol and sea-ice data assimilation for the product performance. Moreover, we

  6. Interplay of demographic variables, birth experience, and initial reactions in the prediction of symptoms of posttraumatic stress one year after giving birth.

    Science.gov (United States)

    König, Julia; Schmid, Sabine; Löser, Eva; Neumann, Olaf; Buchholz, Stefan; Kästner, Ralph

    2016-01-01

    There has been increasing research on posttraumatic stress disorder (PTSD) following childbirth in the last two decades. The literature on predictors of who develops posttraumatic stress symptoms (PSS) suggests that both vulnerability and birth factors have an influence, but many studies measure predictors and outcomes simultaneously. In this context, we aimed to examine indirect and direct effects of predictors of PSS, which were measured longitudinally. We assessed women within the first days ( n =353), 6 weeks, and 12 months ( n =183) after having given birth to a healthy infant. The first assessment included questions on demographics, pregnancy, and birth experience. The second and third assessments contained screenings for postpartum depression, PTSD, and general mental health problems, as well as assessing social support and physical well-being. We analysed our data using structural equation modelling techniques ( n =277). Our final model showed good fit and was consistent with a diathesis-stress model of PSS. Women who had used antidepressant medication in the 10 years before childbirth had higher PSS at 6 weeks, independent of birth experiences. Subjective birth experience was the early predictor with the highest total effect on later PSS. Interestingly, a probable migration background also had a small but significant effect on PSS via more episiotomies. The null results for social support may have been caused by a ceiling effect. Given that we measured predictors at different time points, our results lend important support to the etiological model, namely, that there is a vulnerability pathway and a stress pathway leading to PSS. PSS and other psychological measures stayed very stable between 6 weeks and 1 year postpartum, indicating that it is possible to identify women developing problems early. Our results are consistent with a diathesis-stress model: vulnerability (antidepressant use in the previous 10 years) influenced posttraumatic stress symptoms at

  7. Polarized electrogowdy spacetimes censored

    Energy Technology Data Exchange (ETDEWEB)

    Nungesser, Ernesto, E-mail: ernesto.nungesser@aei.mpg.d [Max-Planck-Institut fuer Gravitationsphysik, Albert-Einstein-Institut, Am Muehlenberg 1, 14476 Potsdam (Germany)

    2010-05-01

    A sketch of the proof of strong cosmic censorship is presented for a class of solutions of the Einstein-Maxwell equations, those with polarized Gowdy symmetry. A key element of the argument is the observation that by means of a suitable choice of variables the central equations in this problem can be written in a form where they are identical to the central equations for general (i.e. non-polarized) vacuum Gowdy spacetimes. Using this it is seen that the results of Ringstroem on strong cosmic censorship in the vacuum case have implications for the Einstein-Maxwell case. Working out the geometrical meaning of these analytical results leads to the main conclusion.

  8. The Swarm Initial Field Model – a Model of the Earth’s Magnetic Field for 2014 Determined From One Year of Swarm Satellite Constellation Data

    DEFF Research Database (Denmark)

    Olsen, Nils; Hulot, Gauthier; Lesur, Vincent

    Almost one year of data from ESA's Swarm constellation mission are used to derive a model of the Earth’s magnetic field and its time variation (secular variation). The model describes contributions from the core and lithosphere as well as large-scale contributions from the magnetosphere (and its......) frame. In addition to the magnetic field observations provided by each of the three Swarm satellites we include the East-west magnetic gradient information provided by the lower Swarm satellite pair, thereby explicitly taking advantage of the constellation aspect of Swarm. We assess the spatial...... and temporal model resolution that can be obtained from one year of Swarm satellite data by comparison with other recent models that also include non-Swarm magnetic observations....

  9. Effects of Initial Body Mass Index and Weight Change on All-Cause Mortality: A 10-Year Cohort Study in Korea.

    Science.gov (United States)

    Park, Susan; Pi, Sunmi; Hwang, Jinseub; Kang, Jae-Heon; Kwon, Jin-Won

    2018-02-01

    We evaluated the effects of baseline body mass index (BMI) and its changes over 4 years on all-cause mortality in Korean population. We analyzed 351 735 participants whose BMI was measured in both 2002/2003 and 2006/2007. Mortality was assessed until 2013. Multivariate hazard ratios for all-cause mortality were estimated. Underweight and severe obesity with BMI >30 kg/m 2 were significantly associated with higher mortality. Similarly, >5% decrease or >10% increase of BMI for 4 years was associated with the increased risk of death. Comparing the results between baseline BMI and BMI change, the BMI change showed more stable associations with mortality than the baseline BMI in subgroup analysis such as nonsmokers and healthy participants. This study suggests that BMI change could be a useful health indicator along with obesity level by BMI. In addition, maintaining a healthy weight is needed for longevity, but rapid weight change should be carefully monitored.

  10. A rare case of Kearns–Sayre syndrome in a 17-year-old Venezuelan male with bilateral ptosis as the initial presentation

    Science.gov (United States)

    Leal, Mayela; Dhoble, Chetan; Lee, Julie; Lopez, Deinymar; Menéndez, Laura Simonne

    2016-01-01

    Kearns–Sayre syndrome (KSS) was first described in 1958 as ‘a rare neuromuscular disorder defined by a characteristic triad of progressive external ophthalmoplegia, pigmentary retinopathy, atrioventricular block and cerebellar ataxia’. The prevalence rate of KSS is ∼1–3 per 100 000 individuals. Here, we report a rare case of a 17-year-old Venezuelan male with KSS. PMID:26949540

  11. PEPPo: Using a Polarized Electron Beam to Produce Polarized Positrons

    Energy Technology Data Exchange (ETDEWEB)

    Adeyemi, Adeleke H. [Hampton Univ., Hampton, VA (United States); et al.

    2015-09-01

    Polarized positron beams have been identified as either an essential or a significant ingredient for the experimental program of both the present and next generation of lepton accelerators (JLab, Super KEK B, ILC, CLIC). An experiment demonstrating a new method for producing polarized positrons has been performed at the Continuous Electron Beam Accelerator Facility at Jefferson Lab. The PEPPo (Polarized Electrons for Polarized Positrons) concept relies on the production of polarized e⁻/e⁺ pairs from the bremsstrahlung radiation of a longitudinally polarized electron beam interacting within a high-Z conversion target. PEPPo demonstrated the effective transfer of spin-polarization of an 8.2 MeV/c polarized (P~85%) electron beam to positrons produced in varying thickness tungsten production targets, and collected and measured in the range of 3.1 to 6.2 MeV/c. In comparison to other methods this technique reveals a new pathway for producing either high-energy or thermal polarized positron beams using a relatively low polarized electron beam energy (~10MeV) .This presentation will describe the PEPPo concept, the motivations of the experiment and high positron polarization achieved.

  12. Polarization induced doped transistor

    Science.gov (United States)

    Xing, Huili; Jena, Debdeep; Nomoto, Kazuki; Song, Bo; Zhu, Mingda; Hu, Zongyang

    2016-06-07

    A nitride-based field effect transistor (FET) comprises a compositionally graded and polarization induced doped p-layer underlying at least one gate contact and a compositionally graded and doped n-channel underlying a source contact. The n-channel is converted from the p-layer to the n-channel by ion implantation, a buffer underlies the doped p-layer and the n-channel, and a drain underlies the buffer.

  13. Polar bears, Ursus maritimus

    Science.gov (United States)

    Rode, Karyn D.; Stirling, Ian

    2017-01-01

    Polar bears are the largest of the eight species of bears found worldwide and are covered in a pigment-free fur giving them the appearance of being white. They are the most carnivorous of bear species consuming a high-fat diet, primarily of ice-associated seals and other marine mammals. They range throughout the circumpolar Arctic to the southernmost extent of seasonal pack ice.

  14. Polarized advanced fuel reactors

    International Nuclear Information System (INIS)

    Kulsrud, R.M.

    1987-07-01

    The d- 3 He reaction has the same spin dependence as the d-t reaction. It produces no neutrons, so that if the d-d reactivity could be reduced, it would lead to a neutron-lean reactor. The current understanding of the possible suppression of the d-d reactivity by spin polarization is discussed. The question as to whether a suppression is possible is still unresolved. Other advanced fuel reactions are briefly discussed. 11 refs

  15. On polarization in biomembranes

    DEFF Research Database (Denmark)

    Zecchi, Karis Amata

    close to physiological conditions, making these effects biologically relevant. In this work, we consider the case of asymmetric membranes which can display spontaneous polarization in the absence of a field. Close to the phase transition, we find that the membrane displays piezoelectric, flexoelectric...... on different geometries point in the direction of a flexoelectric mechanism behind current rectification in lipid bilayers. Finally, we suggest that our updated equivalent circuit should be included in the interpretation of elctrophysiological data....

  16. Multifrequency Behaviour of Polars

    Directory of Open Access Journals (Sweden)

    K. Reinsch

    2015-02-01

    Full Text Available Cataclysmic variables emit over a wide range of the electromagnetic spectrum. In this paper I will review observations of polars in relevant passbands obtained during the last decade and will discuss their diagnostical potential to access the physics of the main components within the binary systems. This will include a discussion of intrinsic source variability and the quest for simultaneous multi-frequency observations.

  17. Role of debriefing as a learning tool in simulation based learning for students of preclinical years at the end of two consecutive modules-initial experience

    International Nuclear Information System (INIS)

    Ali, L.; Nisar, S.; Ghassan, A.

    2015-01-01

    The topic of debriefing has been receiving some attention in the simulation literature. Because of the significance of debriefing on learning, evaluation of the de-briefer is done to ensure optimal performance. Structured debriefing as a learning tool was evaluated at the end of modular teaching of first year MBBS. This study is a descriptive cross sectional study to analyze the usefulness of debriefing as an instructional strategy during observed structured clinical examination conducted at the end of two consecutive modules of first year MBBS students. Methods: Performance of 150 students of first year MBBS was evaluated at the end of modules called Foundation module and skin and musculoskeletal module. Debriefing was structured and conducted after training of six staff members who conducted and supervised Objectively Structured Clinical Examination. Results: Apart from description of results of Objectively Structured Clinical Examination that were generally good, students praised the debriefing session. Ninety percent students thought the timing of debriefing to be perfect. Only 2% percent students complained about negative debriefing. Ten percent students wanted the debriefing session to be conducted in camera so that they could evaluate their own performance. Conclusion: Debriefing session at the end of modular teaching Objectively Structured Clinical Examination is a useful learning tool as not only it provides immediate feedback about the performance but gives students opportunity to discuss own performance with the instructor in order to develop habit of lifelong self-directed adult learner. (author)

  18. Polar Business Design

    Directory of Open Access Journals (Sweden)

    Sébastien Caisse

    2014-02-01

    Full Text Available Polar business design aims to enable entrepreneurs, managers, consultants, researchers, and business students to better tackle model-based analysis, creation, and transformation of businesses, ventures, and, more generically, collective endeavors of any size and purpose. It is based on a systems-thinking approach that builds on a few interrelated core concepts to create holistic visual frameworks. These core concepts act as poles linked by meaningful dyads, flows, and faces arranged in geometric shapes. The article presents two such polar frameworks as key findings in an ongoing analytic autoethnography: the three-pole Value−Activity−Stakeholder (VAS triquetra and the four-pole Offer−Creation−Character−Stakeholder (OCCS tetrahedron. The VAS triquetra is a more aggregated model of collective endeavors. The OCCS tetrahedron makes a trade-off between a steeper learning curve and deeper, richer representation potential. This article discusses how to use these two frameworks as well as their limits, and explores the potential that polar business design offers for future research.

  19. Polarizing matter and antimatter: A new method

    International Nuclear Information System (INIS)

    Onel, Y.

    1992-02-01

    Several years ago a self-polarization effect for stored (anti)- protons and ions was investigated theoretically. The effect is based on the well-known Stern-Gerlach effect in gradient fields. The aim of the ongoing measurements at the Indiana University Cyclotron Facility (IUCF) is to verify experimentally the various assumptions on which this effect is based. The final goal is to demonstrate this new polarization effect. The proposed effect could be a powerful tool to produce polarized stored hadron beams both in the low-energy range and at SSC and LHC energies. In this progress report we will describe our progress in three parts: (A) Experimental work at IUCF Cooler Ring; (B) Our extensive computer simulations of the spin stability for the IUCF Cooler Ring; and (C) Theoretical studies

  20. Early changes in adipokine levels and baseline limb fat may predict HIV lipoatrophy over 2 years following initiation of antiretroviral therapy

    DEFF Research Database (Denmark)

    Calmy, A; Carey, D; Mallon, P W G

    2008-01-01

    plasma collected at baseline and weeks 12, 24 and 48 from adults initiating combination ART. Adipocytokine, inflammatory cytokine, lipid and glycaemic parameters were measured and related to subsequent lipoatrophy (loss of limb fat mass of at least 2 kg from weeks 24 to 96 by dual-energy X......-ray absorptiometry) and an increase in visceral adipose tissue (VAT; an increase of at least 18 cm(2) from baseline to week 48 by abdominal computed tomography). Risk factors associated with limb fat loss and VAT gain were analysed by logistic regression. RESULTS: Fifty-four HIV-infected, treatment-naïve adults were...... levels during the first 6 months of ART, independently predicted a peripheral fat loss of > or = 2 kg [odds ratio (OR) 2.58, 95% confidence interval (CI) 1.04-6.41; OR 3.15, 95% CI 1.34-7.35, respectively). VAT changes showed a borderline association with high baseline tumour necrosis factor-alpha levels...

  1. A new strategy for healthcare-associated pneumonia: a 2-year prospective multicenter cohort study using risk factors for multidrug-resistant pathogens to select initial empiric therapy.

    Science.gov (United States)

    Maruyama, Takaya; Fujisawa, Takao; Okuno, Masataka; Toyoshima, Hirokazu; Tsutsui, Kiyoyuki; Maeda, Hikaru; Yuda, Hisamichi; Yoshida, Masamichi; Kobayashi, Hiroyasu; Taguchi, Osamu; Gabazza, Esteban C; Takei, Yoshiyuki; Miyashita, Naoyuki; Ihara, Toshiaki; Brito, Veronica; Niederman, Michael S

    2013-11-01

    Optimal empiric therapy for hospitalized patients with healthcare-associated pneumonia (HCAP) is uncertain. We prospectively applied a therapeutic algorithm, based on the presence of risk factors for multidrug-resistant (MDR) pathogens in a multicenter cohort study of 445 pneumonia patients, including both community-acquired pneumonia (CAP; n = 124) and HCAP (n = 321). MDR pathogens were more common (15.3% vs 0.8%, P risk factors, one of which was severity of illness (n = 170), vs HCAP patients with 0-1 risk factor (n = 151) had a significantly higher frequency of MDR pathogens (27.1% vs 2%, P risk factor, mortality was lower than with ≥2 MDR risk factors (8.6% vs 18.2%, P = .012). In multivariate analysis, initial treatment failure, but not inappropriate empiric antibiotic therapy, was a mortality risk factor (odds ratio, 72.0). Basing empiric HCAP therapy on its severity and the presence of risk factors for MDR pathogens is a potentially useful approach that achieves good outcomes without excessive use of broad-spectrum antibiotic therapy. Japan Medical Association Center for Clinical Trials, JMA-IIA00054.

  2. Eight years of decreased methicillin-resistant Staphylococcus aureus health care-associated infections associated with a Veterans Affairs prevention initiative.

    Science.gov (United States)

    Evans, Martin E; Kralovic, Stephen M; Simbartl, Loretta A; Jain, Rajiv; Roselle, Gary A

    2017-01-01

    Declines in methicillin-resistant Staphylococcus aureus (MRSA) health care associated infections (HAIs) were previously reported in Veterans Affairs acute care (2012), spinal cord injury (SCIU) (2011), and long-term-care facilities (LTCFs) (2012). Here we report continuing declines in infection rates in these settings through September 2015. Monthly data entered into a national database from 127 acute care facilities, 22 SCIUs, and 133 LTCFs were evaluated for trends using negative binomial regression. There were 23,153,240 intensive care unit (ICU) and non-ICU, and 1,794,234 SCIU patient-days from October 2007-September 2015, and 22,262,605 LTCF resident-days from July 2009-September 2015. Admission nasal swabbing remained >92% in all 3 venues. Admission prevalence changed from 13.2%-13.5% in acute care, from 35.1%-32.0% in SCIUs, and from 23.1%-25.0% in LTCFs during the analysis periods. Monthly HAI rates fell 87.0% in ICUs, 80.1% in non-ICUs, 80.9% in SCIUs, and 49.4% in LTCFs (all P values Prevention Initiative. Published by Elsevier Inc.

  3. High luminosity polarized proton collisions at RHIC

    International Nuclear Information System (INIS)

    Roser, T.

    2001-01-01

    The Brookhaven Relativistic Heavy Ion Collider (RHIC) provides the unique opportunity to collide polarized proton beams at a center-of-mass energy of up to 500 GeV and luminosities of up to 2 x 10 32 cm -2 s -1 . Such high luminosity and high energy polarized proton collisions will open up the possibility of studying spin effects in hard processes. However, the acceleration of polarized beams in circular accelerators is complicated by the numerous depolarizing spin resonances. Using a partial Siberian snake and a rf dipole that ensure stable adiabatic spin motion during acceleration has made it possible to accelerate polarized protons to 25 GeV at the Brookhaven AGS. After successful operation of RHIC with gold beams polarized protons from the AGS have been successfully injected into RHIC and accelerated using a full Siberian snakes built from four superconducting helical dipoles. A new high energy proton polarimeter was also successfully commissioned. Operation with two snakes per RHIC ring is planned for next year

  4. The first cell-fate decision of mouse preimplantation embryo development: integrating cell position and polarity.

    Science.gov (United States)

    Mihajlović, Aleksandar I; Bruce, Alexander W

    2017-11-01

    During the first cell-fate decision of mouse preimplantation embryo development, a population of outer-residing polar cells is segregated from a second population of inner apolar cells to form two distinct cell lineages: the trophectoderm and the inner cell mass (ICM), respectively. Historically, two models have been proposed to explain how the initial differences between these two cell populations originate and ultimately define them as the two stated early blastocyst stage cell lineages. The 'positional' model proposes that cells acquire distinct fates based on differences in their relative position within the developing embryo, while the 'polarity' model proposes that the differences driving the lineage segregation arise as a consequence of the differential inheritance of factors, which exhibit polarized subcellular localizations, upon asymmetric cell divisions. Although these two models have traditionally been considered separately, a growing body of evidence, collected over recent years, suggests the existence of a large degree of compatibility. Accordingly, the main aim of this review is to summarize the major historical and more contemporarily identified events that define the first cell-fate decision and to place them in the context of both the originally proposed positional and polarity models, thus highlighting their functional complementarity in describing distinct aspects of the developmental programme underpinning the first cell-fate decision in mouse embryogenesis. © 2017 The Authors.

  5. Correlations of mesospheric winds with subtle motion of the Arctic polar vortex

    Directory of Open Access Journals (Sweden)

    Y. Bhattacharya

    2010-01-01

    Full Text Available This paper investigates the relationship between high latitude upper mesospheric winds and the state of the stratospheric polar vortex in the absence of major sudden stratospheric warmings. A ground based Michelson Interferometer stationed at Resolute Bay (74°43' N, 94°58' W in the Canadian High Arctic is used to measure mesopause region neutral winds using the hydroxyl (OH Meinel-band airglow emission (central altitude of ~85 km. These observed winds are compared to analysis winds in the upper stratosphere during November and December of 1995 and 1996; years characterized as cold, stable polar vortex periods. Correlation of mesopause wind speeds with those from the upper stratosphere is found to be significant for the 1996 season when the polar vortex is subtly displaced off its initial location by a strong Aleutian High. These mesopause winds are observed to lead stratospheric winds by approximately two days with increasing (decreasing mesospheric winds predictive of decreasing (increasing stratospheric winds. No statistically significant correlations are found for the 1995 season when there is no such displacement of the polar vortex.

  6. The Polar Rock Repository: Rescuing Polar Collections for New Research

    Science.gov (United States)

    Grunow, A.

    2016-12-01

    Geological field expeditions in polar regions are logistically difficult, financially expensive and can have a significant environmental impact on pristine regions. The scarcity of outcrop in Antarctica (98% ice-covered) makes previously collected rock samples very valuable to the science community. NSF recognized the need for preserving rock, dredge, and terrestrial core samples from polar areas and created the Polar Rock Repository (PRR). The PRR collection allows for full and open access to both samples and metadata via the PRR website. In addition to the physical samples and their basic metadata, the PRR archives supporting materials from the collector, field notebooks, images of the samples, field maps, air photos, thin sections and any associated bibliography/DOI's. Many of these supporting materials are unique. More than 40,000 samples are available from the PRR for scientific analysis to researchers around the globe. Most of the samples cataloged at the PRR were collected more than 30 years ago, some more than 100 years ago. The rock samples and metadata are made available online through an advanced search engine for the PRR website. This allows scientists to "drill down" into search results using categories and look-up object fields similar to websites like Amazon. Results can be viewed in a table, downloaded as a spreadsheet, or plotted on an interactive map that supports display of satellite imagery and bathymetry layers. Samples can be requested by placing them in the `shopping cart'. These old sample collections have been repeatedly used by scientists from around the world. One data request involved locating coal deposits in Antarctica for a global compilation and another for looking at the redox state of batholithic rocks from the Antarctic Peninsula using magnetic susceptibilities of PRR rocks. Sample usage has also included non-traditional geologic studies, such as a search for monopoles in Cenozoic volcanic samples, and remote sensing

  7. Bringing Polar Science to the Classroom

    Science.gov (United States)

    Bruccoli, A.; Madsen, J. M.; Porter, M.

    2004-12-01

    The NSF sponsored IceCube (OPP-0236449) and Teachers Experiencing Antarctica and the Arctic (TEA) projects have developed a model for engaging K-12 teachers in a variety of scientific disciplines using polar science as a unifying theme. An intensive workshop, Science in the Ice, provided teachers with background content knowledge and seed ideas for activities aligned with national teaching standards. These activities were used to support the introduction of authentic science investigations related to current polar research in the classroom. The pilot workshop, sponsored by the NSF supported Math-Science Partnership SCALE (0227016), demonstrated the viability of this approach for involving a continuum of teachers from novice to master in a meaningful professional development model that can lead to sustainable classroom changes. This model for teacher professional development is based on the premise that the most robust educational outreach efforts involve teachers that are prepared, supported, and connected to a network of researchers and educators. This network can also serve to both stimulate interest in polar research and as a vehicle for delivering classroom materials related to the International Polar Year. An overview of Science in the Ice will be provided to show how the natural fascination with extreme environments can be used to introduce on-going research to the classroom from multiple disciplines---glaciology, geology, and astrophysics---with a common thread of polar science. The case for involving teachers now to fully capitalize on the potential of the International Polar Year, by providing professional development opportunities including field experiences with researchers, will be made.

  8. Molecular Memory of Morphologies by Septins during Neuron Generation Allows Early Polarity Inheritance.

    Science.gov (United States)

    Boubakar, Leila; Falk, Julien; Ducuing, Hugo; Thoinet, Karine; Reynaud, Florie; Derrington, Edmund; Castellani, Valérie

    2017-08-16

    Transmission of polarity established early during cell lineage history is emerging as a key process guiding cell differentiation. Highly polarized neurons provide a fascinating model to study inheritance of polarity over cell generations and across morphological transitions. Neural crest cells (NCCs) migrate to the dorsal root ganglia to generate neurons directly or after cell divisions in situ. Using live imaging of vertebrate embryo slices, we found that bipolar NCC progenitors lose their polarity, retracting their processes to round for division, but generate neurons with bipolar morphology by emitting processes from the same locations as the progenitor. Monitoring the dynamics of Septins, which play key roles in yeast polarity, indicates that Septin 7 tags process sites for re-initiation of process growth following mitosis. Interfering with Septins blocks this mechanism. Thus, Septins store polarity features during mitotic rounding so that daughters can reconstitute the initial progenitor polarity. Copyright © 2017 Elsevier Inc. All rights reserved.

  9. Initiation Patterns of Statins in the 2 Years After Release of the 2013 American College of Cardiology/American Heart Association (ACC/AHA) Cholesterol Management Guideline in a Large US Health Plan.

    Science.gov (United States)

    Olufade, Temitope; Zhou, Siting; Anzalone, Deborah; Kern, David M; Tunceli, Ozgur; Cziraky, Mark J; Willey, Vincent J

    2017-05-04

    The purpose of this study was to characterize changes in statin utilization patterns in patients newly initiated on therapy in the 2 years following the release of the 2013 American College of Cardiology/American Heart Association (ACC/AHA) cholesterol management guideline in a large US health plan population. This retrospective, observational study used administrative medical and pharmacy claims data to identify patients newly initiated on statin therapy over 4 quarters prior to and 8 quarters following the release of the guideline (average N/quarter=3596). Patients were divided into the 4 statin benefit groups (SBGs) based on risk factors and laboratory lipid levels as defined in the guideline: SBG1 (with atherosclerotic cardiovascular disease [ASCVD]; N=1046/quarter), SBG2 (without ASCVD, with low-density lipoprotein cholesterol ≥190 mg/dL; N=454/quarter), SBG3 (without ASCVD, aged 40-75 years, with diabetes mellitus, low-density lipoprotein cholesterol 70-189 mg/dL; N=1391/quarter), SBG4 (no ASCVD or diabetes mellitus, age 40-75 years, low-density lipoprotein cholesterol 70-189 mg/dL, estimated 10-year ASCVD risk of ≥7.5%; N=705/quarter). Demographic variables, statin utilization patterns, lipid levels, and comorbidities were analyzed for pre- and postguideline periods. Postguideline, gradually increased high-intensity statin initiation occurred in SBG1, SBG2, and in SBG3 patients with 10-year ASCVD risk ≥7.5%. Moderate- to high-intensity statin initiation gradually increased among SBG4 patients. Recommended-intensity statin choice changed to a greater degree among patients treated by specialty care physicians. Regarding sex, target-intensity statin initiation was lower in women in all groups before and after guideline release. Prescriber implementation of the guideline recommendations has gradually increased, with the most marked change in the increased initiation of high-intensity statins in patients with ASCVD and in those treated by a specialist

  10. Comparing identified and statistically significant lipids and polar metabolites in 15-year old serum and dried blood spot samples for longitudinal studies: Comparing lipids and metabolites in serum and DBS samples

    Energy Technology Data Exchange (ETDEWEB)

    Kyle, Jennifer E. [Earth and Biological Sciences Directorate, Pacific Northwest National Laboratory, Richland WA USA; Casey, Cameron P. [Earth and Biological Sciences Directorate, Pacific Northwest National Laboratory, Richland WA USA; Stratton, Kelly G. [National Security Directorate, Pacific Northwest National Laboratory, Richland WA USA; Zink, Erika M. [Earth and Biological Sciences Directorate, Pacific Northwest National Laboratory, Richland WA USA; Kim, Young-Mo [Earth and Biological Sciences Directorate, Pacific Northwest National Laboratory, Richland WA USA; Zheng, Xueyun [Earth and Biological Sciences Directorate, Pacific Northwest National Laboratory, Richland WA USA; Monroe, Matthew E. [Earth and Biological Sciences Directorate, Pacific Northwest National Laboratory, Richland WA USA; Weitz, Karl K. [Earth and Biological Sciences Directorate, Pacific Northwest National Laboratory, Richland WA USA; Bloodsworth, Kent J. [Earth and Biological Sciences Directorate, Pacific Northwest National Laboratory, Richland WA USA; Orton, Daniel J. [Earth and Biological Sciences Directorate, Pacific Northwest National Laboratory, Richland WA USA; Ibrahim, Yehia M. [Earth and Biological Sciences Directorate, Pacific Northwest National Laboratory, Richland WA USA; Moore, Ronald J. [Earth and Biological Sciences Directorate, Pacific Northwest National Laboratory, Richland WA USA; Lee, Christine G. [Department of Medicine, Bone and Mineral Unit, Oregon Health and Science University, Portland OR USA; Research Service, Portland Veterans Affairs Medical Center, Portland OR USA; Pedersen, Catherine [Department of Medicine, Bone and Mineral Unit, Oregon Health and Science University, Portland OR USA; Orwoll, Eric [Department of Medicine, Bone and Mineral Unit, Oregon Health and Science University, Portland OR USA; Smith, Richard D. [Earth and Biological Sciences Directorate, Pacific Northwest National Laboratory, Richland WA USA; Burnum-Johnson, Kristin E. [Earth and Biological Sciences Directorate, Pacific Northwest National Laboratory, Richland WA USA; Baker, Erin S. [Earth and Biological Sciences Directorate, Pacific Northwest National Laboratory, Richland WA USA

    2017-02-05

    The use of dried blood spots (DBS) has many advantages over traditional plasma and serum samples such as smaller blood volume required, storage at room temperature, and ability for sampling in remote locations. However, understanding the robustness of different analytes in DBS samples is essential, especially in older samples collected for longitudinal studies. Here we analyzed DBS samples collected in 2000-2001 and stored at room temperature and compared them to matched serum samples stored at -80°C to determine if they could be effectively used as specific time points in a longitudinal study following metabolic disease. Four hundred small molecules were identified in both the serum and DBS samples using gas chromatograph-mass spectrometry (GC-MS), liquid chromatography-MS (LC-MS) and LC-ion mobility spectrometry-MS (LC-IMS-MS). The identified polar metabolites overlapped well between the sample types, though only one statistically significant polar metabolite in a case-control study was conserved, indicating degradation occurs in the DBS samples affecting quantitation. Differences in the lipid identifications indicated that some oxidation occurs in the DBS samples. However, thirty-six statistically significant lipids correlated in both sample types indicating that lipid quantitation was more stable across the sample types.

  11. Impacts of the Primary School Free Breakfast Initiative on socio-economic inequalities in breakfast consumption among 9-11-year-old schoolchildren in Wales.

    Science.gov (United States)

    Moore, Graham F; Murphy, Simon; Chaplin, Katherine; Lyons, Ronan A; Atkinson, Mark; Moore, Laurence

    2014-06-01

    Universal interventions may widen or narrow inequalities if disproportionately effective among higher or lower socio-economic groups. The present paper examines impacts of the Primary School Free Breakfast Initiative in Wales on inequalities in children's dietary behaviours and cognitive functioning. Cluster-randomised controlled trial. Responses were linked to free school meal (FSM) entitlement via the Secure Anonymised Information Linkage databank. Impacts on inequalities were evaluated using weighted school-level regression models with interaction terms for intervention × whole-school percentage FSM entitlement and intervention × aggregated individual FSM entitlement. Individual-level regression models included interaction terms for intervention × individual FSM entitlement. Fifty-five intervention and fifty-six wait-list control primary schools. Approximately 4500 children completed measures of dietary behaviours and cognitive tests at baseline and 12-month follow-up. School-level models indicated that children in intervention schools ate a greater number of healthy items for breakfast than children in control schools (b = 0·25; 95 % CI 0·07, 0·44), with larger increases observed in more deprived schools (interaction term b = 1·76; 95 % CI 0·36, 3·16). An interaction between intervention and household-level deprivation was not significant. Despite no main effects on breakfast skipping, a significant interaction was observed, indicating declines in breakfast skipping in more deprived schools (interaction term b = -0·07; 95 % CI -0·15, -0·00) and households (OR = 0·67; 95 % CI 0·46, 0·98). No significant influence on inequality was observed for the remaining outcomes. Universal breakfast provision may reduce socio-economic inequalities in consumption of healthy breakfast items and breakfast skipping. There was no evidence of intervention-generated inequalities in any outcomes.

  12. Risk factors for disability pension over 11 years in a cohort of young persons initially sick-listed with low back, neck, or shoulder diagnoses.

    Science.gov (United States)

    Borg, Karin; Hensing, Gunnel; Alexanderson, Kristina

    2004-01-01

    A study was undertaken to ascertain whether the differences in risk in relation to gender and citizenship observed in a previous study of the same cohort would remain if more recent data on sickness absence were used. This was an 11-year prospective population-based cohort study. The dataset includes all individuals in a Swedish city who, in 1985, were aged 25-34 and had a sick-leave spell > or = 28 days with neck, shoulder, or back diagnoses (n=213). The data covered the following: for 1985-96, disability pension, emigration, and death; for 1982-96, sickness absence; for 1985, sex and citizenship. The data were subjected to Cox regression analyses with a time-dependent covariate. Disability pension was granted to 22% (n=46) of the cohort. The relative risk for disability pension increased by 9.3 with each sick-leave spell > or = 90 days during the two previous years. The risk was higher for women than men, and also higher for foreign citizens than Swedes. Many studies have revealed a gender difference in the risk of being on disability pension, and it was found that this difference was still apparent when sick leave during the follow-up period is taken into account. Thus, the reason for the gender differences ought to be found among other factors than prior levels of sickness absence. Copyright 2004 Taylor & Francis

  13. U.S. Department of Energy's initiatives for proliferation prevention in Russia: results of radioactive liquid waste treatment project, year 2

    International Nuclear Information System (INIS)

    Pokhitonov, Y.; Kamachev, V.; Kelley, D.

    2010-10-01

    The objective of the project is to engage weapons scientists with training and research programs at selected nuclear sites in Russia and apply high technology polymers to immobilize legacy ILW and HLW liquids that have posed environmental challenges over the years. One compelling advantage of the projects is that V.G. Khlopin Radium Institute and Pacific Nuclear Solutions have been engaged in applied research for seven years to validate the performance and effectiveness of the polymer technology for use with radioactive liquids. With conclusive results of the research work on sixty active and simulant waste streams, the project can focus on actual applications of the technology at Ozersk (Mayak), Sever sk (SCC) Zheleznogorsk (MCC) and Gatchyna rather that on pure research. The long term objective of the project is find viable waste management solutions for serious radioactive and chemical contamination that has existed in Russia and the U. S. for several decades. The polymer technologies may be applied to all radioactive liquid. This paper summarizes the experimental work of the immobilization process and data definition of the most effective polymer compositions in addition to determining the optimum polymer to liquid ratios for economic considerations. (Author)

  14. The effects of different levels of applied wheat straw in different dates on saffron (Crocus sativus L. daughter corms and flower initiation criteria in the second year

    Directory of Open Access Journals (Sweden)

    Parviz Rezvani Moghaddam

    2013-12-01

    Full Text Available In order to investigate the effects of different levels of applied wheat straw as mulch in different dates on flower characteristics and corms behavior of Saffron (Crocus sativus L. in the second year, a field experiment was conducted as factorial layout based on a randomized complete block design with three replications at Faculty of Agriculture, Ferdowsi University of Mashhad, Iran in years of 2010-2011 and 2011-2012. The experimental treatments were all combination of different levels of wheat straw as mulch (0, 2, 4, 6 and 8 t. ha-1 based on surface applied method in three different dates (June, August and October. The results showed that the applied wheat straw as mulch in different dates had significant effects on flower characteristics of saffron (flower number, fresh and dried flower and stigma+ style yields. Based on these results, applied wheat straw as mulch in October had highest effects on increasing flower number, fresh and dried flower yields (by 46, 61 and 65%, respectively. In addition, applied wheat straw as mulch had significant effects on number and yield of replacement corms. The applied straw as mulch in October increased yield of replacement corms with 12 g or higher weight and total corm yield of saffron by 104 and 103 %, respectively, as compared to control treatment.

  15. Capsize of polarization in dilute photonic crystals.

    Science.gov (United States)

    Gevorkian, Zhyrair; Hakhoumian, Arsen; Gasparian, Vladimir; Cuevas, Emilio

    2017-11-29

    We investigate, experimentally and theoretically, polarization rotation effects in dilute photonic crystals with transverse permittivity inhomogeneity perpendicular to the traveling direction of waves. A capsize, namely a drastic change of polarization to the perpendicular direction is observed in a one-dimensional photonic crystal in the frequency range 10 ÷ 140 GHz. To gain more insights into the rotational mechanism, we have developed a theoretical model of dilute photonic crystal, based on Maxwell's equations with a spatially dependent two dimensional inhomogeneous dielectric permittivity. We show that the polarization's rotation can be explained by an optical splitting parameter appearing naturally in Maxwell's equations for magnetic or electric fields components. This parameter is an optical analogous of Rashba like spin-orbit interaction parameter present in quantum waves, introduces a correction to the band structure of the two-dimensional Bloch states, creates the dynamical phase shift between the waves propagating in the orthogonal directions and finally leads to capsizing of the initial polarization. Excellent agreement between theory and experiment is found.

  16. Polarized Cell Division of Chlamydia trachomatis.

    Directory of Open Access Journals (Sweden)

    Yasser Abdelrahman

    2016-08-01

    Full Text Available Bacterial cell division predominantly occurs by a highly conserved process, termed binary fission, that requires the bacterial homologue of tubulin, FtsZ. Other mechanisms of bacterial cell division that are independent of FtsZ are rare. Although the obligate intracellular human pathogen Chlamydia trachomatis, the leading bacterial cause of sexually transmitted infections and trachoma, lacks FtsZ, it has been assumed to divide by binary fission. We show here that Chlamydia divides by a polarized cell division process similar to the budding process of a subset of the Planctomycetes that also lack FtsZ. Prior to cell division, the major outer-membrane protein of Chlamydia is restricted to one pole of the cell, and the nascent daughter cell emerges from this pole by an asymmetric expansion of the membrane. Components of the chlamydial cell division machinery accumulate at the site of polar growth prior to the initiation of asymmetric membrane expansion and inhibitors that disrupt the polarity of C. trachomatis prevent cell division. The polarized cell division of C. trachomatis is the result of the unipolar growth and FtsZ-independent fission of this coccoid organism. This mechanism of cell division has not been documented in other human bacterial pathogens suggesting the potential for developing Chlamydia-specific therapeutic treatments.

  17. Circular Polarization in Turbulent Blazar Jets

    Directory of Open Access Journals (Sweden)

    Nicholas Roy MacDonald

    2017-11-01

    Full Text Available Circular polarization (CP provides an invaluable probe into the underlying plasma content of relativistic jets. CP can be generated within the jet through a physical process known as linear birefringence. This is a physical mechanism through which initially linearly polarized emission produced in one region of the jet is attenuated by Faraday rotation as it passes through other regions of the jet with distinct magnetic field orientations. Marscher developed the turbulent extreme multi-zone (TEMZ model of blazar emission which mimics these types of magnetic geometries with collections of thousands of plasma cells passing through a standing conical shock. I have recently developed a radiative transfer algorithm to generate synthetic images of the time-dependent circularly polarized intensity emanating from the TEMZ model at different radio frequencies. In this study, we produce synthetic multi-epoch observations that highlight the temporal variability in the circular polarization produced by the TEMZ model. We also explore the effect that different plasma compositions within the jet have on the resultant levels of CP.

  18. Polarization of Hazes and Aurorae on Jupiter

    Science.gov (United States)

    Yanamandra-Fisher, Padma A.; McLean, Will; PACA_Jupiter

    2017-10-01

    Our solar system planets show a large variety of atmospheric polarization properties, from the thick, highly polarizing haze on Titan and the poles of Jupiter, Rayleigh scattering by molecules on Uranus and Neptune, to clouds in the equatorial region of Jupiter or on Venus. Changes in the clouds/thermal filed can be brought about by endogenic dynamical processes such merger of vortices; global, planetary scale upheavals, and external factors such as celestial collisions (such as D/Shoemaker-Levy 9 impact with Jupiter in 1994, etc.). Although the range of phase angles available from Earth for outer planets is restricted to a narrow range, limb polarization measurements provide constraints on the polarimetric properties. For example, at the equator, much of the observed reflected radiation is due to the presence of clouds and therefore, low polarization. Polar asymmetry exists between the two poles, while the planetary disk is unpolarized. Jupiter is known to exhibit a strong polar limb polarization and a low equatorial limb polarization due to the presence of haze particles and Rayleigh scattering at the poles. In contrast, at the equator, the concentration of particulates in the high atmosphere might change, changing the polarimetric signature and aurorae at both poles. The polarimetric maps, in conjunction with thermal maps and albedo maps, can provide constraints on modeling efforts to understand the nature of the aerosols/hazes in Jovian atmosphere. With Jupiter experiencing morphological changes at many latitudes, we have initiated a polarimetric observing campaign of Jupiter, in conjunction with The PACA Project. With NASA/Juno mission in a 53-day orbit around Jupiter, and recent outbreaks in the atmosphere, changes in the polarimetric signature will provide insight to the changes occurring in the atmosphere. Some of our observations are acquired by a team of professional/amateur planetary imagers astronomers based in the U.K., Australia and Europe. France

  19. Bending-Induced Giant Polarization in Ferroelectric MEMS Diaphragm

    KAUST Repository

    Wang, Zhihong

    2016-09-09

    The polarization induced by the strain gradient, i.e. the flexoelectric effect, has been observed in a micromachined Pb(Zr0.52Ti0.48)O3 (PZT) diaphragms. Applying air pressure to bend a flat diaphragm which initially does not exhibit any electromechanical coupling can induce a resonance peak in its impedance spectrum. This result supposes that bending, thus the strain gradient in the diaphragm causes polarization in PZT film. We also investigated the switching behaviors of the polarization in response to an external electric field in a bent diaphragm and further quantified the polarization induced by the strain gradient. The effective flexoelectric coefficient of the PZT film has been calculated as large as 2.0 × 10−4 C/m. A giant flexoelectric polarization of the order of 1 μC/cm2 was characterized which is of the same order of magnitude as the normal remnant ferroelectric polarization of PZT film. The suggested explanation for the giant polarization is the large strain gradient in the diaphragm and the strain gradient induced reorientation of the polar nanodomains.

  20. Optical characterization and polarization calibration for rigid endoscopes

    Science.gov (United States)

    Garcia, Missael; Gruev, Viktor

    2017-02-01

    Polarization measurements give orthogonal information to spectral images making them a great tool in the characterization of environmental parameters in nature. Thus, polarization imagery has proven to be remarkably useful in a vast range of biomedical applications. One such application is the early diagnosis of flat cancerous lesions in murine colorectal tumor models, where polarization data complements NIR fluorescence analysis. Advances in nanotechnology have led to compact and precise bio-inspired imaging sensors capable of accurately co-registering multidimensional spectral and polarization information. As more applications emerge for these imagers, the optics used in these instruments get very complex and can potentially compromise the original polarization state of the incident light. Here we present a complete optical and polarization characterization of three rigid endoscopes of size 1.9mm x 10cm (Karl Storz, Germany), 5mm x 30cm, and 10mm x 33cm (Olympus, Germany), used in colonoscopy for the prevention of colitis-associated cancer. Characterization results show that the telescope optics act as retarders and effectively depolarize the linear component. These incorrect readings can cause false-positives or false-negatives leading to an improper diagnosis. In this paper, we offer a polarization calibration scheme for these endoscopes based on Mueller calculus. By modeling the optical properties from training data as real-valued Mueller matrices, we are able to successfully reconstruct the initial polarization state acquired by the imaging system.

  1. Advancing the education in molecular diagnostics: the IFCC-Initiative "Clinical Molecular Biology Curriculum" (C-CMBC); a ten-year experience.

    Science.gov (United States)

    Lianidou, Evi; Ahmad-Nejad, Parviz; Ferreira-Gonzalez, Andrea; Izuhara, Kenji; Cremonesi, Laura; Schroeder, Maria-Eugenia; Richter, Karin; Ferrari, Maurizio; Neumaier, Michael

    2014-09-25

    Molecular techniques are becoming commonplace in the diagnostic laboratory. Their applications influence all major phases of laboratory medicine including predisposition/genetic risk, primary diagnosis, therapy stratification and prognosis. Readily available laboratory hardware and wetware (i.e. consumables and reagents) foster rapid dissemination to countries that are just establishing molecular testing programs. Appropriate skill levels extending beyond the technical procedure are required for analytical and diagnostic proficiency that is mandatory in molecular genetic testing. An international committee (C-CMBC) of the International Federation for Clinical Chemistry (IFCC) was established to disseminate skills in molecular genetic testing in member countries embarking on the respective techniques. We report the ten-year experience with different teaching and workshop formats for beginners in molecular diagnostics. Copyright © 2014 Elsevier B.V. All rights reserved.

  2. Erosive progression is minimal, but erosion healing rare, in patients with rheumatoid arthritis treated with adalimumab. A 1 year investigator-initiated follow-up study using high-resolution computed tomography as the primary outcome measure

    DEFF Research Database (Denmark)

    Møller Døhn, U; Boonen, A; Hetland, M L

    2009-01-01

    two low-grade radiographic erosions in the wrist or metacarpophalangeal (MCP) joints in the same (index) hand, initiated adalimumab 40 mg subcutaneously every other week. Thirty-five patients completed the study (median age 61 years (interquartile range 46-68), disease duration 8 years (3-15)). CT...... of the index wrist and MCP joints 2-5 and radiographs of hands and forefeet were obtained at baseline, 6 and 12 months. Images were evaluated by investigators blinded to chronology and clinical data, and assessed according to Sharp/van der Heijde (radiographs) and OMERACT RA MRI scoring (CT) methods. RESULTS...

  3. Interplay of demographic variables, birth experience, and initial reactions in the prediction of symptoms of posttraumatic stress one year after giving birth

    Directory of Open Access Journals (Sweden)

    Julia König

    2016-10-01

    Full Text Available Background: There has been increasing research on posttraumatic stress disorder (PTSD following childbirth in the last two decades. The literature on predictors of who develops posttraumatic stress symptoms (PSS suggests that both vulnerability and birth factors have an influence, but many studies measure predictors and outcomes simultaneously. Objective: In this context, we aimed to examine indirect and direct effects of predictors of PSS, which were measured longitudinally. Method: We assessed women within the first days (n=353, 6 weeks, and 12 months (n=183 after having given birth to a healthy infant. The first assessment included questions on demographics, pregnancy, and birth experience. The second and third assessments contained screenings for postpartum depression, PTSD, and general mental health problems, as well as assessing social support and physical well-being. We analysed our data using structural equation modelling techniques (n=277. Results: Our final model showed good fit and was consistent with a diathesis-stress model of PSS. Women who had used antidepressant medication in the 10 years before childbirth had higher PSS at 6 weeks, independent of birth experiences. Subjective birth experience was the early predictor with the highest total effect on later PSS. Interestingly, a probable migration background also had a small but significant effect on PSS via more episiotomies. The null results for social support may have been caused by a ceiling effect. Conclusions: Given that we measured predictors at different time points, our results lend important support to the etiological model, namely, that there is a vulnerability pathway and a stress pathway leading to PSS. PSS and other psychological measures stayed very stable between 6 weeks and 1 year postpartum, indicating that it is possible to identify women developing problems early.

  4. Inception cohort study of workers exposed to toluene diisocyanate at a polyurethane foam factory: initial one-year follow-up.

    Science.gov (United States)

    Gui, Wei; Wisnewski, Adam V; Neamtiu, Iulia; Gurzau, Eugen; Sparer, Judith A; Stowe, Meredith H; Liu, Jian; Slade, Martin D; Rusu, Olivia A; Redlich, Carrie A

    2014-11-01

    Isocyanates are one of the most commonly reported causes of occupational asthma; however, the risks of developing isocyanate asthma in modern production facilities remain poorly defined. We evaluated TDI exposure and respiratory health among an inception cohort of workers during their first year of employment at a new polyurethane foam production factory. Forty-nine newly hired workers were evaluated pre-employment, 6-months, and 12-months post-employment through questionnaire, spirometry, and TDI-specific serology. Airborne TDI levels were monitored by fixed-point air sampling and limited personal sampling. Qualitative surface SWYPE™ tests were performed to evaluate potential sources of skin exposure. Airborne TDI levels overall were low; over 90% of fixed-point air measurements were below the limit of detection (0.1 ppb). Over the first year of employment, 12 of the 49 original workers (24.5%) were lost to follow-up, no additional workers were enrolled, and seven of the 49 original workers (14.2%) developed either new asthma symptoms (N = 3), TDI-specific IgG (N = 1), new airflow obstruction (N = 1) and/or a decline in FEV1  ≥ 15% (N = 3), findings that could indicate TDI-related health effects. The prevalence of current asthma symptoms was significantly higher in the workers lost to follow-up compared to those who completed the 12-month follow-up (25% vs. 2.7%; P = 0.04). The findings suggest possible early TDI-related health effects in a modern polyurethane production plant. These findings also highlight the need for further longitudinal evaluation of these workers and the challenges of studying workers at risk for isocyanate asthma. © 2014 Wiley Periodicals, Inc.

  5. Building AN International Polar Data Coordination Network

    Science.gov (United States)

    Pulsifer, P. L.; Yarmey, L.; Manley, W. F.; Gaylord, A. G.; Tweedie, C. E.

    2013-12-01

    In the spirit of the World Data Center system developed to manage data resulting from the International Geophysical Year of 1957-58, the International Polar Year 2007-2009 (IPY) resulted in significant progress towards establishing an international polar data management network. However, a sustained international network is still evolving. In this paper we argue that the fundamental building blocks for such a network exist and that the time is right to move forward. We focus on the Arctic component of such a network with linkages to Antarctic network building activities. A review of an important set of Network building blocks is presented: i) the legacy of the IPY data and information service; ii) global data management services with a polar component (e.g. World Data System); iii) regional systems (e.g. Arctic Observing Viewer; iv) nationally focused programs (e.g. Arctic Observing Viewer, Advanced Cooperative Arctic Data and Information Service, Polar Data Catalogue, Inuit Knowledge Centre); v) programs focused on the local (e.g. Exchange for Local Observations and Knowledge of the Arctic, Geomatics and Cartographic Research Centre). We discuss current activities and results with respect to three priority areas needed to establish a strong and effective Network. First, a summary of network building activities reports on a series of productive meetings, including the Arctic Observing Summit and the Polar Data Forum, that have resulted in a core set of Network nodes and participants and a refined vision for the Network. Second, we recognize that interoperability for information sharing fundamentally relies on the creation and adoption of community-based data description standards and data delivery mechanisms. There is a broad range of interoperability frameworks and specifications available; however, these need to be adapted for polar community needs. Progress towards Network interoperability is reviewed, and a prototype distributed data systems is demonstrated. We

  6. Improving the Teaching Skills of Residents in a Surgical Training Program: Results of the Pilot Year of a Curricular Initiative in an Ophthalmology Residency Program.

    Science.gov (United States)

    Chee, Yewlin E; Newman, Lori R; Loewenstein, John I; Kloek, Carolyn E

    2015-01-01

    To design and implement a teaching skills curriculum that addressed the needs of an ophthalmology residency training program, to assess the effect of the curriculum, and to present important lessons learned. A teaching skills curriculum was designed for the Harvard Medical School (HMS) Residency Training Program in Ophthalmology. Results of a needs assessment survey were used to guide curriculum objectives. Overall, 3 teaching workshops were conducted between October 2012 and March 2013 that addressed areas of need, including procedural teaching. A postcurriculum survey was used to assess the effect of the curriculum. Massachusetts Eye and Ear Infirmary, a tertiary care institution in Boston, MA. Overall, 24 residents in the HMS Residency Training Program in Ophthalmology were included. The needs assessment survey demonstrated that although most residents anticipated that teaching would be important in their future career, only one-third had prior formal training in teaching. All residents reported they found the teaching workshops to be either very or extremely useful. All residents reported they would like further training in teaching, with most residents requesting additional training in best procedural teaching practices for future sessions. The pilot year of the resident-as-teacher curriculum for the HMS Residency Training Program in Ophthalmology demonstrated a need for this curriculum and was perceived as beneficial by the residents, who reported increased comfort in their teaching skills after attending the workshops. Copyright © 2015 Association of Program Directors in Surgery. Published by Elsevier Inc. All rights reserved.

  7. Cardiac tamponade mimicking tuberculous pericarditis as the initial presentation of chronic lymphocytic leukemia in a 58-year-old woman: a case report

    Directory of Open Access Journals (Sweden)

    Nathan Sandeep

    2010-08-01

    Full Text Available Abstract Introduction Chronic lymphocytic leukemia is an indolent disease that often presents with complaints of lymphadenopathy or is detected as an incidental laboratory finding. It is rarely considered in the differential diagnosis of patients presenting with tamponade or a large, bloody pericardial effusion. In patients without known cancer, a large, bloody pericardial effusion raises the possibility of tuberculosis, particularly in patients from endemic areas. However, the signs, symptoms and laboratory findings of pericarditis related to chronic lymphocytic leukemia can mimic tuberculosis. Case Presentation We report the case of a 58-year-old African American-Nigerian woman with a history of travel to Nigeria and a positive tuberculin skin test who presented with cardiac tamponade. She had a mild fever, lymphocytosis and a bloody pericardial effusion, but cultures and stains were negative for acid-fast bacteria. Assessment of blood by flow cytometry and pericardial biopsy by immunohistochemistry revealed CD5 (+ and CD20 (+ lymphocytes in both tissues, demonstrating this to be an unusual manifestation of early stage chronic lymphocytic leukemia. Conclusion Although most malignancies that involve the pericardium clinically manifest elsewhere before presenting with tamponade, this case illustrates the potential for early stage chronic lymphocytic leukemia to present as a large pericardial effusion with tamponade. Moreover, the presentation mimicked tuberculosis. This case also demonstrates that it is possible to treat chronic lymphocytic leukemia-related pericardial tamponade by removal of the fluid without chemotherapy.

  8. Circularly polarized antennas

    CERN Document Server

    Gao, Steven; Zhu, Fuguo

    2013-01-01

    This book presents a comprehensive insight into the design techniques for different types of CP antenna elements and arrays In this book, the authors address a broad range of topics on circularly polarized (CP) antennas. Firstly, it introduces to the reader basic principles, design techniques and characteristics of various types of CP antennas, such as CP patch antennas, CP helix antennas, quadrifilar helix antennas (QHA), printed quadrifilar helix antennas (PQHA), spiral antenna, CP slot antennas, CP dielectric resonator antennas, loop antennas, crossed dipoles, monopoles and CP horns. Adva

  9. Plasma polarization spectroscopy

    CERN Document Server

    Iwamae, Atsushi

    2008-01-01

    Plasma Polarization Spectroscopy (PPS) is now becoming a standard diagnostic technique for working with laboratory plasmas. This new area needs a comprehensive framework, both experimental and theoretical. This book reviews the historical development of PPS, develops a general theoretical formulation to deal with this phenomenon, along with an overview of relevant cross sections, and reports on laboratory experiments so far performed. It also includes various facets that are interesting from this standpoint, e.g. X-ray lasers and effects of microwave irradiation. It also offers a timely discussion of instrumentation that is quite important in a practical PPS experiment.

  10. Polar ocean stratification in a cold climate.

    Science.gov (United States)

    Sigman, Daniel M; Jaccard, Samuel L; Haug, Gerald H

    2004-03-04

    The low-latitude ocean is strongly stratified by the warmth of its surface water. As a result, the great volume of the deep ocean has easiest access to the atmosphere through the polar surface ocean. In the modern polar ocean during the winter, the vertical distribution of temperature promotes overturning, with colder water over warmer, while the salinity distribution typically promotes stratification, with fresher water over saltier. However, the sensitivity of seawater density to temperature is reduced as temperature approaches the freezing point, with potential consequences for global ocean circulation under cold climates. Here we present deep-sea records of biogenic opal accumulation and sedimentary nitrogen isotopic composition from the Subarctic North Pacific Ocean and the Southern Ocean. These records indicate that vertical stratification increased in both northern and southern high latitudes 2.7 million years ago, when Northern Hemisphere glaciation intensified in association with global cooling during the late Pliocene epoch. We propose that the cooling caused this increased stratification by weakening the role of temperature in polar ocean density structure so as to reduce its opposition to the stratifying effect of the vertical salinity distribution. The shift towards stratification in the polar ocean 2.7 million years ago may have increased the quantity of carbon dioxide trapped in the abyss, amplifying the global cooling.

  11. System for measuring the proton polarization in a polarized target

    International Nuclear Information System (INIS)

    Karnaukhov, I.M.; Lukhanin, A.A.; Telegin, Yu.N.; Trotsenko, V.I.; Chechetenko, V.F.

    1984-01-01

    The system for measuring the proton polarization in a polarized target representing the high-sensitivity nuclear magnetic resonance (NMR) is described Q-meter with series connection and a circuit for measuring system resonance characteristic is used for NMR-absorption signal recording. Measuring coil is produced of a strip conductor in order to obtain uniform system sensitivity to polarization state in all target volume and improve signal-to-noise ratio. Polarization measuring system operates ion-line with the M-6000 computer. The total measuring error for the value of free proton polarization in target taking into account the error caused by local depolarization of working substance under irradiation by high-intense photon beam is <= 6%. Long-term application of the described system for measuring the proton polarization in the LUEh-20000 accelerator target used in the pion photoproduction experiments has demonstrated its high reliability

  12. A new backscatter lidar for the whole-year study of temperatures and clouds in the polar stratosphere and mesosphere; Ein neues Rueckstreu-Lidar zur ganzjaehrigen Untersuchung von Temperaturen und Wolkenphaenomenen in der polaren Strato- und Mesosphaere

    Energy Technology Data Exchange (ETDEWEB)

    Mueller, K.P.

    2000-01-01

    Temperatures in the polar middle atmosphere can fall to extremely low values leading to cloud formation in otherwise cloud-free regions: in summer near the mesopause i.e. noctiluent clouds (NLC) and in winter in the lower stratosphere, i.e. polar stratospheric clouds (PSC). Both clouds are environmentally important, PSCs in the ozone problem and NLCs as early indicators of climate change. To investigate these clouds and to measure temperature profiles the atmospheric physics group set up a backscatter lidar on the Esrange in northern Sweden. Based on our experience with a lidar in Norway the mechanics and optics were redesigned to allow for simultaneous measurements of the depolarization of the backscattered light, three colour measurements and measurements in daylight. A numerical simulation of the daylight filter characteristics suggests that the presently used tuning method should be replaced. The first measurements with this new lidar design on the Esrange were obtained in January 1997. PSCs were observed on 19 days from January to March. Surprisingly, PSCs of type 2 were detected several times even when though synoptic stratospheric temperatures were too warm for such clouds to exist. Temperatures in the lee of the Scandinavian mountains had been lowered by internal waves sufficiently to generate PSC type 2 clouds. Among the previous PSC-observations in January 1995 when the lidar was located on the Norwegian island Andoeya was a singular PSC of type 2 on on January 14, 1995, which had a surface area density two orders of magnitudes higher than typically assumed in theoretical models describing ozone depletion. (orig.)

  13. Understanding drivers of Demand for Emergency Service Trends in Years 2010-2014 in New South Wales: An initial overview of the DESTINY project.

    Science.gov (United States)

    Dinh, Michael M; Berendsen Russell, Saartje; Bein, Kendall J; Chalkley, Dane; Muscatello, David; Paoloni, Richard; Ivers, Rebecca

    2016-04-01

    This study aims to describe the general characteristics and data definitions used in a population-based data set of ED presentations in New South Wales (NSW), used to form the basis of future-trend analyses. Retrospective analysis of the Emergency Department Data Collection registry, which provided clinical and demographic information of ED presentations across all EDs in NSW between 2010 and 2014. Presenting problems and ED diagnoses were classified using broad clinical categories including injury/musculoskeletal, respiratory, cardiovascular, ear nose and throat, and mental health. Presentations were linked by patient to allow for analysis of representations, and population data were obtained from the Australian Bureau of Statistics. There were 11.8 million presentations that were analysed from 150 EDs (80.6% of all EDs). The rate of ED presentations was highest in those aged 85 years and older and appears to increase across all age groups between 2010 and 2014. The most common ED diagnosis categories were injury/musculoskeletal (27.5%) followed by abdominal/gastrointestinal (12.3%), respiratory (9%) and cardiovascular (8%). Both the Systematised Nomenclature of Medicine Clinical Terms (66%) and the International Classification of Diseases (24%) were used to code ED diagnoses. The elderly population had the highest rate of ED attendances. The use of diverse diagnosis classifications and source information systems may present problems with further analysis. Patterns and characteristics of ED presentations in NSW were broadly consistent with those reported in other states in Australia. © 2016 Australasian College for Emergency Medicine and Australasian Society for Emergency Medicine.

  14. Anisotropic structures of some microorganisms studied by polarization microscopy

    Czech Academy of Sciences Publication Activity Database

    Žižka, Zdeněk

    2014-01-01

    Roč. 59, č. 5 (2014), s. 363-368 ISSN 0015-5632 Institutional support: RVO:61388971 Keywords : Polarization microscopy * microorganism Subject RIV: EE - Microbiology, Virology Impact factor: 1.000, year: 2014

  15. Summary of Research through Phase II/Year 2 of Initially Approved 3 Phase/3 Year Project - Establishing the Relationship between Fracture-Related Dolomite and Primary Rock Fabric on the Distribution of Reservoirs in the Michigan Basin

    Energy Technology Data Exchange (ETDEWEB)

    G. Grammer

    2007-09-30

    This final scientific/technical report covers the first 2 years (Phases I and II of an originally planned 3 Year/3 Phase program). The project was focused on evaluating the relationship between fracture-related dolomite and dolomite constrained by primary rock fabric in the 3 most prolific reservoir intervals in the Michigan Basin. The characterization of select dolomite reservoirs was the major focus of our efforts in Phases I and II of the project. Structural mapping and log analysis in the Dundee (Devonian) and Trenton/Black River (Ordovician) suggest a close spatial relationship among gross dolomite distribution and regional-scale, wrench fault-related NW-SE and NE-SW structural trends. A high temperature origin for much of the dolomite in these 2 studied intervals (based upon fluid inclusion homogenization temperatures and stable isotopic analyses,) coupled with persistent association of this dolomite in reservoirs coincident with wrench fault-related features, is strong evidence for these reservoirs being influenced by hydrothermal dolomitization. In the Niagaran (Silurian), there is a general trend of increasing dolomitization shelfward, with limestone predominant in more basinward positions. A major finding is that facies types, when analyzed at a detailed level, are directly related to reservoir porosity and permeability in these dolomites which increases the predictability of reservoir quality in these units. This pattern is consistent with our original hypothesis of primary facies control on dolomitization and resulting reservoir quality at some level. The identification of distinct and predictable vertical stacking patterns within a hierarchical sequence and cycle framework provides a high degree of confidence at this point that the results should be exportable throughout the basin. Much of the data synthesis and modeling for the project was scheduled to be part of Year 3/Phase III, but the discontinuation of funding after Year 2 precluded those efforts

  16. Short forms of the Child Perceptions Questionnaire for 11–14-year-old children (CPQ11–14: Development and initial evaluation

    Directory of Open Access Journals (Sweden)

    Locker David

    2006-01-01

    Full Text Available Abstract Background The Child Perceptions Questionnaire for children aged 11 to 14 years (CPQ11–14 is a 37-item measure of oral-health-related quality of life (OHRQoL encompassing four domains: oral symptoms, functional limitations, emotional and social well-being. To facilitate its use in clinical settings and population-based health surveys, it was shortened to 16 and 8 items. Item impact and stepwise regression methods were used to produce each version. This paper describes the developmental process, compares the discriminative properties of the resulting four short-forms and evaluates their precision relative to the original CPQ11–14. Methods The item impact method used data from the CPQ11–14 item reduction study to select the questions with the highest impact scores in each domain. The regression method, where the dependent variable was the overall CPQ11–14 score and the independent variables its individual questions, was applied to the data collected in the validity study for the CPQ11–14. The measurement properties (i.e. criterion validity, construct validity, internal consistency reliability and test-retest reliability of all 4 short-forms were evaluated using the data from the validity and reliability studies for the CPQ11–14. Results All short forms detected substantial variability in children's OHRQoL. The mean scores on the two 16-item questionnaires were almost identical, while on the two 8-item questionnaires they differed by only one score point. The mean scores standardized to 0–100 were higher on the short forms than the original CPQ11–14 (p 11–14 scores (0.87–0.98; p Conclusion All short forms demonstrated excellent criterion validity and good construct validity. The reliability coefficients exceeded standards for group-level comparisons. However, these are preliminary findings based on the convenience sampling and further testing in replicated studies involving clinical and general samples of children in

  17. Drilling Polar Oceans with the European Research Icebreaker AURORA BOREALIS: the IODP Context

    Science.gov (United States)

    Lembke-Jene, Lester; Wolff-Boenisch, Bonnie; Azzolini, Roberto; Thiede, Joern; Biebow, Nicole; Eldholm, Olav; Egerton, Paul

    2010-05-01

    Polar oceans are characterized by extreme environmental conditions for humans and materials, and have remained the least accessible regions to scientists of the IODP. DSDP and ODP have for long faced specific technical and logistical problems when attempting to drill in ice-covered polar deep-sea basins. The Arctic Ocean and large areas of the high-latitude Southern Ocean remained largely un-sampled by ODP and remain one of the major scientific and technological challenges for IODP. Drilling in these regions has been discussed and anticipated for decades and the scientific rationales are reflected in the science plans of the international Nansen Arctic Drilling Program (NAD) or the Arctic Program Planning Group (APPG) of ODP/IODP, amongst others. More recently, the rationale to investigate the polar oceans in a holistic approach has been outlined by workshops, leading to strategic assessments of the scientific potential and new drilling proposals. The European Polar Board took the initiative to develop a plan for a novel and dedicated research icebreaker with technical capabilities hitherto unrealised. This research icebreaker will enable autonomous operations in the central Arctic Ocean and the Southern Ocean, even during the severest ice conditions in the deep winter, serving all marine disciplines of polar research including scientific drilling: The European Research Icebreaker and Deep-Sea Drilling Vessel AURORA BOREALIS. AURORA BOREALIS is presently planned as a multi-purpose vessel. The ship can be deployed as a research icebreaker in all polar waters during any season of the year, as it shall meet the specifications of the highest ice-class attainable (IACS Polar Code 1) for icebreakers. During the times when it is not employed for drilling, it will operate as the most technically advanced multi-disciplinary research vessel in the Arctic or polar Southern Ocean. AURORA BOREALIS will be a "European scientific flagship facility" (fully open to non

  18. Polar drive on OMEGA

    Directory of Open Access Journals (Sweden)

    Radha P.B.

    2013-11-01

    Full Text Available High-convergence polar-drive experiments are being conducted on OMEGA [T. R. Boehly et al., Opt. Commum. 133, 495 (1997] using triple-picket laser pulses. The goal of OMEGA experiments is to validate modeling of oblique laser deposition, heat conduction in the presence of nonradial thermal gradients in the corona, and implosion energetics in the presence of laser–plasma interactions such as crossed-beam energy transfer. Simulated shock velocities near the equator, where the beams are obliquely incident, are within 5% of experimentally inferred values in warm plastic shells, well within the required accuracy for ignition. High, near-one-dimensional areal density is obtained in warm-plastic-shell implosions. Simulated backlit images of the compressing core are in good agreement with measured images. Outstanding questions that will be addressed in the future relate to the role of cross-beam transfer in polar drive irradiation and increasing the energy coupled into the target by decreasing beam obliquity.

  19. Preparing for Operational Use of High Priority Products from the Joint Polar Satellite System (JPSS) in Numerical Weather Prediction

    Science.gov (United States)

    Nandi, S.; Layns, A. L.; Goldberg, M.; Gambacorta, A.; Ling, Y.; Collard, A.; Grumbine, R. W.; Sapper, J.; Ignatov, A.; Yoe, J. G.

    2017-12-01

    This work describes end to end operational implementation of high priority products from National Oceanic and Atmospheric Administration's (NOAA) operational polar-orbiting satellite constellation, to include Suomi National Polar-orbiting Partnership (S-NPP) and the Joint Polar Satellite System series initial satellite (JPSS-1), into numerical weather prediction and earth systems models. Development and evaluation needed for the initial implementations of VIIRS Environmental Data Records (EDR) for Sea Surface Temperature ingestion in the Real-Time Global Sea Surface Temperature Analysis (RTG) and Polar Winds assimilated in the National Weather Service (NWS) Global Forecast System (GFS) is presented. These implementations ensure continuity of data in these models in the event of loss of legacy sensor data. Also discussed is accelerated operational implementation of Advanced Technology Microwave Sounder (ATMS) Temperature Data Records (TDR) and Cross-track Infrared Sounder (CrIS) Sensor Data Records, identified as Key Performance Parameters by the National Weather Service. Operational use of SNPP after 28 October, 2011 launch took more than one year due to the learning curve and development needed for full exploitation of new remote sensing capabilities. Today, ATMS and CrIS data positively impact weather forecast accuracy. For NOAA's JPSS initial satellite (JPSS-1), scheduled for launch in late 2017, we identify scope and timelines for pre-launch and post-launch activities needed to efficiently transition these capabilities into operations. As part of these alignment efforts, operational readiness for KPPs will be possible as soon as 90 days after launch. The schedule acceleration is possible because of the experience with S-NPP. NOAA operational polar-orbiting satellite constellation provides continuity and enhancement of earth systems observations out to 2036. Program best practices and lessons learned will inform future implementation for follow-on JPSS-3 and -4

  20. THE ISSUE OF TURKISH DURING THE INITIAL YEARS OF MODERN AZERBAIJANI LITERATURE MODERN AZERBAYCAN EDEBİYATININ KURULUŞ YILLARINDA TÜRKÇE MES’ELESİ

    Directory of Open Access Journals (Sweden)

    Ali EROL

    2011-01-01

    Full Text Available Efforts and endeavours towards using Turkish as the language of literature in Azerbaijan were arduous and painful as in Turkey. Populist approaches starting with Molla Penah Vagıf in the 17th c. and particularly the efforts of Ahundov, Zerdabi and Şirvani in the second half of the 19th c. afforded a more organised and systematic quality for Azeri literature, which was under the Arabian and Persian influence for many years. However it was not until the beginning of the 20th c. that we see an emphasis on the concept of mother tongue in Azerbaijan more extensively than before. Apparently the role and contribution of “Maarifçiler”, who were quick to work hard by taking advantage of the liberal atmosphere induced by the 1905 Manifest, was important.The period witnesses a debate between “public language” supported by Molla Nasreddin group and “Istanbul Türkçesi” supported by writers of Füyuzat as to what the language of literature should be. Such discussions and works contributed to the elimination of foreign elements in Azerbaijani Turkish. Türkçenin edebî dil olarak kullanılması yönündeki gayret ve çalışmalar, tıpkı bizde olduğu gibi Azerbaycan kültür sahasında da sancılı bir seyir izlemiştir. Uzun yıllar Arap ve Fars etkisi altında kalan Azerbaycan edebiyatında XVII. yy’da Molla Penah Vagıf ile başlayan halkçı yaklaşımlar, özellikle XIX. yy’ın ikinci yarısından itibaren Ahundov, Zerdabî ve Şirvanî gibi isimlerle daha organize ve sistemli bir yapıya kavuşmuştur.Bununla birlikte Azerbaycan’da ana dili kavramının daha yoğun bir şekilde vurgulandığı dönem XX. yy.’ın başlarıdır. Bu gelişmede şüphesiz ki 1905 Manifestosu’nun yarattığı hürriyetçi atmosferi fırsat bilerek harekete geçen “Maarifçiler”in rolü büyük olmuştur. Aynı dönemde edebî sahada da daha çok Molla Nasreddin grubunun temsil ettiği “halk dili” tezi ile, Füyûzat yazarlarının savundu

  1. Palynology in a polar desert, eastern North Greenland

    DEFF Research Database (Denmark)

    Funder, Svend Visby; Abrahamsen, Niels

    1988-01-01

    history back to c. 7,000 years calBP (6,000 years convBP) in this·extreme environment, which presents the coldest thermal regime where vascular plants can grow. The diagram shows that polar desert developed from sparse high arctic tundra at c. 4,300 years calBP (3,900 years convBP), owing...

  2. Polarized proton collider at RHIC

    Energy Technology Data Exchange (ETDEWEB)

    Alekseev, I.; Allgower, C.; Bai, M.; Batygin, Y.; Bozano, L.; Brown, K.; Bunce, G.; Cameron, P.; Courant, E.; Erin, S.; Escallier, J.; Fischer, W.; Gupta, R.; Hatanaka, K.; Huang, H.; Imai, K.; Ishihara, M.; Jain, A.; Lehrach, A.; Kanavets, V.; Katayama, T.; Kawaguchi, T.; Kelly, E.; Kurita, K.; Lee, S.Y.; Luccio, A.; MacKay, W.W. E-mail: mackay@bnl.govhttp://www.rhichome.bnl.gov/People/waldowaldo@bnl.gov; Mahler, G.; Makdisi, Y.; Mariam, F.; McGahern, W.; Morgan, G.; Muratore, J.; Okamura, M.; Peggs, S.; Pilat, F.; Ptitsin, V.; Ratner, L.; Roser, T.; Saito, N.; Satoh, H.; Shatunov, Y.; Spinka, H.; Syphers, M.; Tepikian, S.; Tominaka, T.; Tsoupas, N.; Underwood, D.; Vasiliev, A.; Wanderer, P.; Willen, E.; Wu, H.; Yokosawa, A.; Zelenski, A.N

    2003-03-01

    In addition to heavy ion collisions (RHIC Design Manual, Brookhaven National Laboratory), RHIC will also collide intense beams of polarized protons (I. Alekseev, et al., Design Manual Polarized Proton Collider at RHIC, Brookhaven National Laboratory, 1998, reaching transverse energies where the protons scatter as beams of polarized quarks and gluons. The study of high energy polarized protons beams has been a long term part of the program at BNL with the development of polarized beams in the Booster and AGS rings for fixed target experiments. We have extended this capability to the RHIC machine. In this paper we describe the design and methods for achieving collisions of both longitudinal and transverse polarized protons in RHIC at energies up to {radical}s=500 GeV.

  3. Spin exchange in polarized deuterium

    International Nuclear Information System (INIS)

    Przewoski, B. von; Meyer, H.O.; Balewski, J.; Doskow, J.; Ibald, R.; Pollock, R.E.; Rinckel, T.; Wellinghausen, A.; Whitaker, T.J.; Daehnick, W.W.; Haeberli, W.; Schwartz, B.; Wise, T.; Lorentz, B.; Rathmann, F.; Pancella, P.V.; Saha, Swapan K.; Thoerngren-Engblom, P.

    2003-01-01

    We have measured the vector and tensor polarization of an atomic deuterium target as a function of the target density. The polarized deuterium was produced in an atomic beam source and injected into a storage cell. For this experiment, the atomic beam source was operated without rf transitions, in order to avoid complications from the unknown efficiency of these transitions. In this mode, the atomic beam is vector and tensor polarized and both polarizations can be measured simultaneously. We used a 1.2-cm-diam and 27-cm-long storage cell, which yielded an average target density between 3 and 9x10 11 at/cm 3 . We find that the tensor polarization decreases with increasing target density while the vector polarization remains constant. The data are in quantitative agreement with the calculated effect of spin exchange between deuterium atoms at low field

  4. Linear polarization of BY Draconis

    International Nuclear Information System (INIS)

    Koch, R.H.; Pfeiffer, R.J.

    1976-01-01

    Linear polarization measurements are reported in four bandpasses for the flare star BY Dra. The red polarization is intrinsically variable at a confidence level greater than 99 percent. On a time scale of many months, the variability is not phase-locked to either a rotational or a Keplerian ephemeris. The observations of the three other bandpasses are useful principally to indicate a polarization spectrum rising toward shorter wavelengths

  5. Polarity in Mammalian Epithelial Morphogenesis

    OpenAIRE

    Roignot, Julie; Peng, Xiao; Mostov, Keith

    2013-01-01

    Cell polarity is fundamental for the architecture and function of epithelial tissues. Epithelial polarization requires the intervention of several fundamental cell processes, whose integration in space and time is only starting to be elucidated. To understand what governs the building of epithelial tissues during development, it is essential to consider the polarization process in the context of the whole tissue. To this end, the development of three-dimensional organotypic cell culture model...

  6. 16th International Workshop on Polarized Sources, Targets, and Polarimetry (PSTP 2015)

    CERN Document Server

    2015-01-01

    The Workshop on Polarized Sources, Targets and Polarimetry has been a tradition for more than 20 years, moving between Europe, USA and Japan. The XVIth International Workshop on Polarized Sources, Targets and Polarimetry (PSTP 2015) will take place at the Ruhr-University of Bochum, Germany. The workshop addresses the physics and technological challenges related to polarized gas/solid targets, polarized electron/positron/ion/neutron sources, polarimetry and their applications. will be published in Proceedings of Science

  7. A polarized alkali ion source

    International Nuclear Information System (INIS)

    Boettger, R.; Tungate, G.; Bauer, B.; Egelhof, P.; Moebius, K.H.; Steffens, E.

    1978-01-01

    The beam foil technique has been applied to detect nuclear vector polarization of a 10 keV 23 Na + beam. The result was about 70% of the atomic beam polarization thus limiting the depolarization by the surface ionizer to at most 30%. In a Coulomb excitation experiment with a tensor polarized 42 MeV 23 Na 7+ beam an effect of 0.011 +- 0.003 was measured yielding a value of t 20 approx. 0.04 for the beam polarization. The depolarization during the acceleration process can be estimated to be about 0.8. (orig.) [de

  8. The SLAC polarized electron source

    International Nuclear Information System (INIS)

    Tang, H.; Alley, R.; Frisch, J.

    1995-06-01

    The SLAC polarized electron source employs a photocathode DC high voltage gun with a loadlock and a YAG pumped Ti:sapphire laser system for colliding beam experiments or a flash lamp pumped Ti:sapphire laser for fixed target experiments. It uses a thin, strained GaAs(100) photocathode, and is capable of producing a pulsed beam with a polarization of ≥80% and a peak current exceeding 10 A. Its operating efficiency has reached 99%. The physics and technology of producing high polarization electron beams from a GaAs photocathode will be reviewed. The prospects of realizing a polarized electron source for future linear colliders will also be discussed

  9. Diagnosis of initial changes in patients suffering from rheumatoid arthritis. Two years follow up control with a low-field magnetic resonance scanner, 3-phase bone scintigraphy and conventional X-ray

    International Nuclear Information System (INIS)

    Hoepfner, S.; Treitl, M.; Becker-Gaab, C.; Krolak, C.; Weiss, M.; Tiling, R.

    2004-01-01

    Besides conventional X-ray, in the diagnostic work up of initial changes in patients suffering from rheumatoid arthritis (RA), 3-phase bone scintigraphy (3P-Sz) is as well established as magnetic resonance imaging (MRI). The aim of this study was to compare the diagnostic value of a newly developed low field MRI with proven methods such as conventional X-ray and 3P-Sz. Patients, methods: 42 patients were studied using a one day's protocol with 3P-Sz, MRI, and X-ray of the hands with yearly follow up examinations. Images were visually assessed by two blinded nuclear medicine physicians and radiologists and classified as RA-typical and non-RA-typical changes. All methods were compared to the summarised findings interpreted by a rheumatologist in consideration of the Ritchie articular index as gold-standard. Results: 24/42 patients presented with clinical symptoms of initial changes by rheumatoid arthritis. Conventional X-ray revealed in 20/24 patients within the correct diagnosis in the study period. On the other hand 3P-Sz and low field MRI concordantly showed all 24 patients with initial changes due to RA. Time of detection showed variations with a tendency to later findings by conventional X-ray. Conclusions: In the diagnostic work up of initial changes conventional X-ray should be the first choice in imaging. Our findings suggest that MRI represents an equally sensitive method for the diagnosis of initial changes due to RA in the region of the hands as compared to the 3P-Sz. The limitation of the low field MRI is the small field of view, so we prefer 3P-Sz or high field MRI in the diagnosis of patients with suspected RA. (orig.) [de

  10. Modeling optical and UV polarization of AGNs II. Polarization imaging and complex reprocessing

    Czech Academy of Sciences Publication Activity Database

    Marin, F.; Goosmann, R. W.; Gaskell, C.M.; Porquet, D.; Dovčiak, Michal

    2012-01-01

    Roč. 548, December (2012), A121/1-A121/25 ISSN 0004-6361 R&D Projects: GA MŠk LD12010 Institutional support: RVO:67985815 Keywords : actva galaxies * polarization Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics Impact factor: 5.084, year: 2012

  11. Constraining foreground spectrum with the projection-induced polarization for the cosmological global 21-cm experiments

    Science.gov (United States)

    Nhan, Bang D.; Bradley, Richard F.; Burns, Professor O.

    2018-01-01

    Detecting the cosmological global (sky-averaged) 21-cm spectrum as a function of observed frequency will provide a powerful tool to study the thermal history of intergalactic medium (IGM) in the high-redshift Universe (~ 400 million years after the Big Bang). The biggest challenge in conventional ground-based total-power global 21-cm experiments is the removal of the Galactic and extragalactic synchrotron foreground (~ 1e4-1e5 K) to uncover the weak cosmological signal (~ 10-100 mK). The foreground is further corrupted by the frequency-dependent instrumental systematics. We have developed a new polarimetry-based observational approach that aims to measure the foreground emission by modulating it as a function of time through its circumpolar motion. Due to geometry, the projection of the anisotropic foreground sources onto the dual-polarized antenna induces a net foreground polarization, which is distinct from the much weaker intrinsic polarization of synchrotron sources. Instead of pointing the radio antenna at the zenith as in the conventional experiments, we point the antenna at the North Celestial Pole (NCP) and measure the projection-induced polarization modulated by the foreground's circumpolar diurnal periodicity. This temporal signature allows us to separate the dynamic foreground spectrum from the static cosmological background. In this presentation, we describe the design, construction, and initial results from the "Cosmic Twilight Polarimeter'' (CTP) as a proof-of-concept implementation of this technique. The instrument consists of a dual-polarized broadband antenna (60-120 MHz) with a two-stage thermally stabilized front-end electronics, tilted toward the NCP. The instrument is currently being evaluated at a site near Charlottesville, VA. Ultimately, the instrument will be relocated to an RFI-quiet site closer to the Geographic North Pole (GNP) to mitigate sky obstruction due to the horizon at a lower latitude.

  12. PolarTREC-Teachers and Researchers Exploring and Collaborating: Bringing Polar Research to the Classroom

    Science.gov (United States)

    Warnick, W. K.; Warburton, J.; Breen, K.; Wiggins, H. V.; Larson, A.; Behr, S.

    2006-12-01

    PolarTREC-Teachers and Researchers Exploring and Collaborating is a three-year (2007-2009) teacher professional development program that pairs K-12 teachers with researchers to improve science education through authentic polar research experience. PolarTREC builds on the strengths of the existing TREC program in the Arctic, an NSF supported program managed by the Arctic Research Consortium of the US (ARCUS), to embrace a wider range of research activities in the Arctic and Antarctic. PolarTREC uses a Teacher Research Experience (TRE) model to foster the integration of research and education to produce a legacy of long-term teacher-researcher collaborations, improved teacher content knowledge through experiences in scientific inquiry, and broad public interest and engagement in polar science. PolarTREC will enable thirty-six teachers to spend two to six weeks in the Arctic or Antarctic, working closely with researchers investigating a wide range of topics such as sea-ice dynamics, terrestrial ecology, marine biology, atmospheric chemistry, and long-term climate change. With the help of their host researcher and the research team, teachers will develop the experience and tools necessary to teach science through scientific inquiry and investigation based on real-world experiences. While in the field, teachers and researchers will communicate extensively with their colleagues, communities, and hundreds of students of all ages across the globe, using a variety of tools including satellite phones, online journals, podcasts and interactive "Live from IPY" calls and web-based seminars. The online outreach elements of the project convey these experiences to a broad audience far beyond the classrooms of the PolarTREC teachers. In addition to field research experiences, PolarTREC will support teacher professional development and a sustained community of teachers, scientists, and the public through workshops, Internet seminars, an e-mail listserve, and ongoing teacher

  13. Efficient ionizer for polarized H/sup -/ formation

    Energy Technology Data Exchange (ETDEWEB)

    Alessi, J.G.

    1985-01-01

    An ionizer is under development for a polarized H/sup -/ source based on the resonant charge exchange reaction polarized H/sup 0/ + D/sup -/ ..-->.. polarized H/sup -/ + D/sup 0/. The polarized H/sup 0/ beam passes through the center of a magnetron surface-plasma source having an annular geometry, where it crosses a high current (approx.0.5 A), 200 eV D/sup -/ beam. Calculations predict an H/sup 0/ ..-->.. H/sup -/ ionization efficiency of approx.7%, more than an order of magnitude higher than that obtained on present ground state atomic beam sources. In initial experiments using an unpolarized H/sup 0/ beam, H/sup -/ currents in excess of 100 ..mu..A have been measured. While the ionization efficiency is now only about the same as other methods (Cs beam, for example), the results are encouraging since it appears that by injecting positive ions to improve the space-charge neutralization, and by improving the extraction optics, considerable gains in intensity will be made. We will then use this ionizer with a polarized H/sup 0/ beam, and measure the polarization of the resulting H/sup -/ beam. If no depolarization is observed this ionizer will be combined with an atomic beam, cooled to 5 to 6 K, to give a polarized H/sup -/ beam expected to be in the milliampere range for use in the AGS.

  14. Geomagnetic excursions reflect an aborted polarity state

    Science.gov (United States)

    Valet, Jean-Pierre; Plenier, Guillaume; Herrero-Bervera, E.

    2008-10-01

    Geomagnetic excursions represent short episodes of a few thousand years at most during which the field considerably exceeds its normal range of variability during a polarity state. Paleomagnetic records have now been obtained with extremely high temporal resolution which have improved our knowledge of these short events. We have compiled the most detailed records of excursions that had occurred during the Brunhes and Matuyama chrons. We show that virtual geomagnetic poles (VGPs) of at least one record of each event are able to reach the opposite polarity. In the next step, we have computed different simulations of excursions during which the dipole progressively vanishes before growing back without reversing. This scenario produces very few reversed directions which are only visible at some latitudes. We infer that it is impossible to reach the ratio of reversed to intermediate VGPs present in the paleomagnetic records if the excursions were not associated with a short period of reversed dipole field. Therefore, excursions should be regarded as two successive reversals bracketing an aborted polarity interval. We propose that the same underlying mechanisms prevail in both situations (excursions or reversals) and that below a certain strength the field reaches an unstable position which preludes either the achievement of a reversal or its return to the former polarity.

  15. Circularly Polarized Microwave Antenna Element with Very Low Off-Axis Cross-Polarization

    Science.gov (United States)

    Greem. David; DuToit, Cornelis

    2013-01-01

    The goal of this work was to improve off-axis cross-polarization performance and ease of assembly of a circularly polarized microwave antenna element. To ease assembly, the initial design requirement of Hexweb support for the internal circuit part, as well as the radiating disks, was eliminated. There is a need for different plating techniques to improve soldering. It was also desirable to change the design to eliminate soldering as well as the need to use the Hexweb support. Thus, a technique was developed to build the feed without using solder, solving the lathing and soldering issue. Internal parts were strengthened by adding curvature to eliminate Hexweb support, and in the process, the new geometries of the internal parts opened the way for improving the off-axis cross-polarization performance as well. The radiating disks curvatures were increased for increased strength, but it was found that this also improved crosspolarization. Optimization of the curvatures leads to very low off-axis cross-polarization. The feed circuit was curved into a cylinder for improved strength, eliminating Hexweb support. An aperture coupling feed mechanism eliminated the need for feed pins to the disks, which would have required soldering. The aperture coupling technique also improves cross-polarization performance by effectively exciting the radiating disks very close to the antenna s central axis of symmetry. Because of the shape of the parts, it allowed for an all-aluminum design bolted together and assembled with no solder needed. The advantage of a solderless design is that the reliability is higher, with no single-point failure (solder), and no need for special plating techniques in order to solder the unit together. The shapes (curved or round) make for a more robust build without extra support materials, as well as improved offaxis cross-polarization.

  16. CMB polarization from secondary vector and tensor modes

    International Nuclear Information System (INIS)

    Mollerach, Silvia; Harari, Diego; Matarrese, Sabino

    2004-01-01

    We consider a novel contribution to the polarization of the cosmic microwave background induced by vector and tensor modes generated by the nonlinear evolution of primordial scalar perturbations. Our calculation is based on relativistic second-order perturbation theory and allows us to estimate the effects of these secondary modes on the polarization angular power spectra. We show that a nonvanishing B-mode polarization unavoidably arises from pure scalar initial perturbations, thus limiting our ability to detect the signature of primordial gravitational waves generated during inflation. This secondary effect dominates over that of primordial tensors for an inflationary tensor-to-scalar ratio r -6 . The magnitude of the effect is smaller than the contamination produced by the conversion of polarization of type E into type B, by weak gravitational lensing. However, the lensing signal can be cleaned, making the secondary modes discussed here the actual background limiting the detection of small amplitude primordial gravitational waves

  17. Larynx preservation after initial non-cisplatin containing combination chemotherapy plus radiotherapy, as opposed to surgical intervention with or without radiotherapy in previously untreated advanced head and neck cancer: final analysis after 12 years follow-up

    Energy Technology Data Exchange (ETDEWEB)

    Price, L.A.; Shaw, H.J.; Hill, B.T. (Imperial Cancer Research Fund, London (United Kingdom). Labs.)

    1993-03-01

    After a median follow-up of 12 years, median overall survival of 73 patients with advanced squamous cell carcinoma of the larynx was 65 months. The 61% of patients responding to two courses of initial schedule A combination chemotherapy, not including cisplatin, and the 81% of patients achieving a final complete remission after definitive local therapy, had median overall survival figures of 95 and 97 months respectively. Overall survival and relapse-free survival in 51 patients treated with radiotherapy only with larynx preservation, were not significantly different from the 21 patients who completed their surgery with pre- or post-operative radiotherapy; median overall figures were 71 versus 65 months. (author).

  18. Impact of the CO2 and H2O clouds of the Martian polar hood on the polar energy balance

    Science.gov (United States)

    Forget, Francois; Pollack, James B.

    1993-01-01

    Clouds covering extensive areas above the martian polar caps have regularly been observed during the fall and winter seasons of each hemisphere. These 'polar hoods' are thought to be made of H2O and CO2. In particular, the very cold temperatures observed during the polar night by Viking and Mariner 9 around both poles have been identified as CO2 clouds and several models, including GCM, have indicated that the CO2 can condense in the atmosphere at all polar latitudes. Estimating the impact of the polar hood clouds on the energy balance of the polar regions is necessary to model the CO2 cycle and address puzzling problems like the polar caps assymetry. For example, by altering the thermal radiation emitted to space, CO2 clouds alter the amount of CO2 that condenses during the fall and winter season. The complete set of Viking IRTM data was analyzed to define the spatial and temporal properties of the polar hoods, and how their presence affects the energy radiated by the atmosphere/caps system to space was estimated. The IRTM observations provide good spatial and temporal converage of both polar regions during fall, winter, and spring, when a combination of the first and the second Viking year is used. Only the IRTM brightness temperatures at 11, 15, and 20 microns are reliable at martian polar temperatures. To recover the integrated thermal fluxes from the IRTM data, a simple model of the polar hood, thought to consist of 'warm' H2O clouds lying above colder and opaque CO2 clouds was developed. Such a model is based on the analysis of the IRIS spectra, and is consistent with the IRTM data used.

  19. 1996 environmental initiatives report

    International Nuclear Information System (INIS)

    1996-01-01

    Progress by Consumers Gas in addressing environmental challenges were reviewed. Proposed environmental initiatives for the next fiscal year and beyond were introduced. Proposed initiatives were placed into three priority categories, high, medium or low, which together with the environmental management framework form the the utility's overall environmental agenda. High on the list of environmental priorities for the company are atmospheric air emissions, planning and construction practices, energy conservation and efficiency, environmental compliance, and methane emissions. The present state of the initiatives by the various company divisions and regions, compiled from the respective business plans, were reported. 21 figs

  20. Initial Study

    DEFF Research Database (Denmark)

    Torp, Kristian

    2009-01-01

    Congestion is a major problem in most cities and the problem is growing (Quiroga, 2000) (Faghri & Hamad, 2002). When the congestion level is increased the drivers notice this as delays in the traffic (Taylor, Woolley, & Zito, 2000), i.e., the travel time for the individual driver is simply...... increased. In the initial study presented here, the time it takes to pass an intersection is studied in details. Two major signal-controlled four-way intersections in the center of the city Aalborg are studied in details to estimate the congestion levels in these intersections, based on the time it takes...

  1. Polar Biomedical Research - An Assessment.

    Science.gov (United States)

    1982-10-01

    to grow more crops in subpolar Alaska. The severity of the polar conditions in Antarctica allow no practical method for providing volumes of plant food...for an expanded population. Any experiments in polar regions in food production involving geothermal heat, solar energy, hydroponics , or aquaculture

  2. Create a Polarized Light Show.

    Science.gov (United States)

    Conrad, William H.

    1992-01-01

    Presents a lesson that introduces students to polarized light using a problem-solving approach. After illustrating the concept using a slinky and poster board with a vertical slot, students solve the problem of creating a polarized light show using Polya's problem-solving methods. (MDH)

  3. Carbon nanotube fiber terahertz polarizer

    Energy Technology Data Exchange (ETDEWEB)

    Zubair, Ahmed [Department of Electrical and Computer Engineering, Rice University, Houston, Texas 77005 (United States); Tsentalovich, Dmitri E.; Young, Colin C. [Department of Chemical and Biomolecular Engineering, Rice University, Houston, Texas 77005 (United States); Heimbeck, Martin S. [Charles M. Bowden Laboratory, Aviation & Missile Research, Development, and Engineering Center (AMRDEC), Redstone Arsenal, Alabama 35898 (United States); Everitt, Henry O. [Department of Electrical and Computer Engineering, Rice University, Houston, Texas 77005 (United States); Charles M. Bowden Laboratory, Aviation & Missile Research, Development, and Engineering Center (AMRDEC), Redstone Arsenal, Alabama 35898 (United States); Pasquali, Matteo [Department of Chemical and Biomolecular Engineering, Rice University, Houston, Texas 77005 (United States); Department of Chemistry, Rice University, Houston, Texas 77005 (United States); Department of Materials Science and NanoEngineering, Rice University, Houston, Texas 77005 (United States); Kono, Junichiro, E-mail: kono@rice.edu [Department of Electrical and Computer Engineering, Rice University, Houston, Texas 77005 (United States); Department of Materials Science and NanoEngineering, Rice University, Houston, Texas 77005 (United States); Department of Physics and Astronomy, Rice University, Houston, Texas 77005 (United States)

    2016-04-04

    Conventional, commercially available terahertz (THz) polarizers are made of uniformly and precisely spaced metallic wires. They are fragile and expensive, with performance characteristics highly reliant on wire diameters and spacings. Here, we report a simple and highly error-tolerant method for fabricating a freestanding THz polarizer with nearly ideal performance, reliant on the intrinsically one-dimensional character of conduction electrons in well-aligned carbon nanotubes (CNTs). The polarizer was constructed on a mechanical frame over which we manually wound acid-doped CNT fibers with ultrahigh electrical conductivity. We demonstrated that the polarizer has an extinction ratio of ∼−30 dB with a low insertion loss (<0.5 dB) throughout a frequency range of 0.2–1.1 THz. In addition, we used a THz ellipsometer to measure the Müller matrix of the CNT-fiber polarizer and found comparable attenuation to a commercial metallic wire-grid polarizer. Furthermore, based on the classical theory of light transmission through an array of metallic wires, we demonstrated the most striking difference between the CNT-fiber and metallic wire-grid polarizers: the latter fails to work in the zero-spacing limit, where it acts as a simple mirror, while the former continues to work as an excellent polarizer even in that limit due to the one-dimensional conductivity of individual CNTs.

  4. Polarization-preserving holey fibers

    DEFF Research Database (Denmark)

    Broeng, Jes; Mogilevtsev, Dmitri; Libori, Stig E. Barkou

    2001-01-01

    In this work we suggest and discuss a microstructure of air capillaries with elliptical cross-section in a tread of glass that gives opportunity for Creation of polarization-preserving fiber with very small beat length between the fundamental modes of different polarization...

  5. Polarized Scintillating Targets at Psi

    Science.gov (United States)

    van den Brandt, B.; Bunyatova, E. I.; Hautle, P.; Konter, J. A.; Mango, S.

    2001-02-01

    Scintillating polarized targets are now routinely available: blocks of 18×18×5 mm scintillating organic polymer, doped with TEMPO, polarized dynamically in a field of 2.5 T in a vertical 3He-4He dilution refrigerator. A 19 mm diameter plastic lightguide transports the scintillation light from the sample in the mixing chamber to a photomultiplier outside the cryostat.

  6. UV Coatings, Polarization, and Coronagraphy

    Science.gov (United States)

    Bolcar, Matthew R.; Quijada, Manuel; West, Garrett; Balasubramanian, Bala; Krist, John; Martin, Stefan; Sabatke, Derek

    2016-01-01

    Presenation for the Large UltraViolet Optical Infrared (LUVOIR) and Habitable Exoplanet Imager (HabEx) Science and Technology Definition Teams (STDT) on technical considerations regarding ultraviolet coatings, polarization, and coronagraphy. The presentations review the state-of-the-art in ultraviolet coatings, how those coatings generate polarization aberrations, and recent study results from both the LUVOIR and HabEx teams.

  7. Climate Drives Polar Bear Origins

    Science.gov (United States)

    In their provocative analysis of northern bears (“Nuclear genomic sequences reveal that polar bears are an old and distinct bear lineage,” Reports, 20 April, p. 344), F. Hailer et al. use independent nuclear loci to show that polar bears originated during the middle Pleistocene, rather than during t...

  8. Integrins and epithelial cell polarity.

    Science.gov (United States)

    Lee, Jessica L; Streuli, Charles H

    2014-08-01

    Cell polarity is characterised by differences in structure, composition and function between at least two poles of a cell. In epithelial cells, these spatial differences allow for the formation of defined apical and basal membranes. It has been increasingly recognised that cell-matrix interactions and integrins play an essential role in creating epithelial cell polarity, although key gaps in our knowledge remain. This Commentary will discuss the mounting evidence for the role of integrins in polarising epithelial cells. We build a model in which both inside-out signals to polarise basement membrane assembly at the basal surface, and outside-in signals to control microtubule apical-basal orientation and vesicular trafficking are required for establishing and maintaining the orientation of epithelial cell polarity. Finally, we discuss the relevance of the basal integrin polarity axis to cancer. This article is part of a Minifocus on Establishing polarity. © 2014. Published by The Company of Biologists Ltd.

  9. Asymmetry ratio in pair production and the degree of linearly polarized photons at intermediate energies

    CERN Document Server

    Asai, J

    1999-01-01

    In order to initiate the experiments using linearly polarized tagged photons at intermediate energies, it is imperative to know and to monitor the degree of polarization. The relationship is re-examined between the linear polarization of photons and the asymmetry ratio in pair production by such photons. An improved method is proposed in which pairs are prohibited from entering the cone region around the incident photon beam. By restricting the directions of pairs, the asymmetry ratio is much improved. (author)

  10. A review of polarized ion sources

    International Nuclear Information System (INIS)

    Schmor, P.W.

    1995-06-01

    The two main types of polarized ion sources in use on accelerators today are the Atomic Beam Polarized Ion Source (ABIS) source and the Optically Pumped Polarized Ion Source (OPPIS). Both types can provide beams of nuclearly polarized light ions which are either positively or negatively charged. Heavy ion polarized ion sources for accelerators are being developed. (author). 35 refs., 1 tab

  11. CU’s Department of Geological Sciences - Science Education Initiative Project (GEOL-SEI): A five-year plan for introducing and supporting an evidence-based and scientific approach to teaching

    Science.gov (United States)

    Arthurs, L.; Budd, D. A.

    2009-12-01

    The Science Education Initiative (SEI) at the University of Colorado at Boulder was conceived in 2006 with the goal of improving science education at the undergraduate level by changing the basic approach to teaching in science departments. Five departments were selected on a competitive basis for participation in the SEI. The SEI is operating as a five year plan with funding of ~$1 million/year for the five departments. The goal of the SEI is to implement sustainable department-level change for an evidence-based and scientific approach to teaching. Among the five departments receiving funding for discipline-specific SEI projects is the Department of Geological Sciences (GEOL-SEI). The GEOL-SEI has worked to transform geology courses beginning with lower division large enrollment courses and moving towards upper division courses. They are transformed on the basis of existing research into how people learn, and they are characterized by the use of learning goals and effective instructional approaches. Furthermore, a natural component of the transformation towards evidence-based and scientific approaches to teaching is geocognition and geoscience education research. This research focuses on how students think about geologic concepts (e.g. misconceptions) and the effectiveness of different instructional approaches (e.g. the implementation of instructional technologies, peer learning activities, homework, and labs). The research is conducted by post-doctoral fellows (with PhDs in geology and pedagogical training) in collaboration with the instructional faculty members. The directorate of CU’s Science Education Initiative provides the fellows with training useful for conducting the research. Currently, into the 4th year of its 5-year plan, the GEOL-SEI is working towards publishing its findings and exploring options for sustaining various changes made to courses and new departmental programs that support student learning (e.g. GEOL Tutoring & Study Room).

  12. Development of polarization magneto-optics of paramagnetic crystals

    International Nuclear Information System (INIS)

    Zapasskij, V.S.; Feofilov, P.P.

    1975-01-01

    The present status of the polarization magnetooptics of crystals containing paramagnetic ion impurities is reviewed. The paper discusses methods of measurement of circular magnetic anisotropy and results obtained in recent years in the field of conventional magnetooptical studies, e.g., magnetooptical activity in absorption spectra for intrinsic and impurity defects in crystals, luminescence magnetic circular polarization, anisotropy of magnetooptical activity in cubic crystals. The main emphasis is placed on new trends in polarization magnetooptics: studies of interactions of a spin system with a lattice, in particular, spin-lattice relaxation and spin memory effect, experiments in the double radiooptical resonance, studies of optical spin relaxation, nonlinear magnetooptical effects, etc

  13. Virtually Shaping the Future of Polar Research

    Science.gov (United States)

    Baeseman, J. L.; Koldunov, N. V.; Jochum, K.

    2009-12-01

    The Association of Polar Early Career Scientists (APECS) is an international and interdisciplinary organization for undergraduate and graduate students, postdoctoral researchers, early faculty members, educators and others with interests in Polar Regions and the wider cryosphere that started as a result of the International Polar Year (IPY). APECS is leading the way for virtual communication of polar research through several activities: an online Polar Literature Discussion Forum, a Virtual Poster Session, and Communication beyond the conference setting. APECS has created an extensive online discussion forum where researchers share both classic and cutting-edge literature articles and critique techniques that were used by authors, helping to improve methods as well as discover new ways to approach polar research questions. Many researchers present their results as posters at conferences. APECS has taken this process to a new level by creating a format to display previously presented posters online instead of these files simply sitting on a researcher’s hard-drive. Not only are the posters online, a monthly conference call open to hundreds of participants allows researchers to share their work with a new audience - fellow researchers, community members, potential colleagues, policy makers and educators. These calls are recorded and archived online so the next time someone visits the poster, they can hear the researcher describe their work and communicate with the researcher questions they may have, potential ways to collaborate or share different methodologies to improve future endeavors. Peer-reviewed literature articles are the currency of science and APECS has capitalized on this by creating a way for researchers to increase the exposure of their publications beyond the table of contents published by journals. The Polar Literature Discussion Forum is a new way for researchers to share their papers, as well as discuss classic articles. This has become a popular

  14. Macrophage Polarization in Metabolism and Metabolic Disease

    Directory of Open Access Journals (Sweden)

    Anna Meiliana

    2013-08-01

    Full Text Available BACKGROUND: Obesity is now recognized as the main cause of the worldwide epidemic of type 2 diabetes. Obesity-associated chronic inflammation is a contributing key factor for type 2 diabetes and cardiovascular disease. Numbers of studies have clearly demonstrated that the immune system and metabolism are highly integrated. CONTENT: Macrophages are an essential component of innate immunity and play a central role in inflammation and host defense. Moreover, these cells have homeostatic functions beyond defense, including tissue remodeling in ontogenesis and orchestration of metabolic functions. Diversity and plasticity are hallmarks of cells of the monocyte-macrophage lineage. In response to interferons (IFNs, toll-like receptor (TLR, or interleukin (IL-4/IL-13 signals, macrophages undergo M1 (classical or M2 (alternative activation. Progress has now been made in defining the signaling pathways, transcriptional networks, and epigenetic mechanisms underlying M1, M2 or M2-like polarized activation. SUMMARY: In response to various signals, macrophages may undergo classical M1 activation (stimulated by TLR ligands and IFN-γ or alternative M2 activation (stimulated by IL-4/IL-13; these states mirror the T helper (Th1–Th2 polarization of T cells. Pathology is frequently associated with dynamic changes in macrophage activation, with classically activated M1 cells implicate in initiating and sustaining inflammation, meanwhile M2 or M2-like activated cells associated with resolution or smoldering chronic inflammation. Identification of the mechanisms and molecules that are associated with macrophage plasticity and polarized activation provides a basis for macrophage centered diagnostic and therapeutic strategies. KEYWORDS: obesity, adipose tissue, inflammation, macrophage polarization.

  15. POLARIZED LIGHT IN PHYSIOTHERAPY

    Directory of Open Access Journals (Sweden)

    L. D. Tondiy

    2015-12-01

    Full Text Available The data on polarized light (PS - a new promising treatment, rehabilitation and prevention, which took its deserved place among the known therapeutic physical factors and may even compete with laser radiation of low and LED therapy. It is reflected the significant contribution of domestic scientists in the study of aircraft action on the body, its introduction in the treatment, rehabilitation and prevention of grippe, ARI. These action's mechanisms of the aircraft on the electro-physiological processes in the body that have the leading role in the regulation of its life. The new moment in the study of aircraft on the body is the evidence of its positive impact on the mechanisms of self body - its different units: the disease's banning - a revitalization of the stress-protective, stress-limiting system antioxidial, detoxification and other protection systems, the formation by the body antiviral and antimicrobial specific substances (interferon and lysozyme, activation of the immune system, phagocytosis, protective functions of skin. The protective and mobilizing role of the second link is studied: which is triggered in case of occurrence of disease or preexisting diseases: PL mobilized processes of restitution, reparations, compensation, immunity and microcirculation. The authors studied the possibility of aircraft's using to enhance performance, reduce side effects of physical factors, which are often used in the treatment (electric methods, treatment by sound, fresh and mineral water, etc..

  16. Update of the Polar SWIFT model for polar stratospheric ozone loss (Polar SWIFT version 2)

    Science.gov (United States)

    Wohltmann, Ingo; Lehmann, Ralph; Rex, Markus

    2017-07-01

    The Polar SWIFT model is a fast scheme for calculating the chemistry of stratospheric ozone depletion in polar winter. It is intended for use in global climate models (GCMs) and Earth system models (ESMs) to enable the simulation of mutual interactions between the ozone layer and climate. To date, climate models often use prescribed ozone fields, since a full stratospheric chemistry scheme is computationally very expensive. Polar SWIFT is based on a set of coupled differential equations, which simulate the polar vortex-averaged mixing ratios of the key species involved in polar ozone depletion on a given vertical level. These species are O3, chemically active chlorine (ClOx), HCl, ClONO2 and HNO3. The only external input parameters that drive the model are the fraction of the polar vortex in sunlight and the fraction of the polar vortex below the temperatures necessary for the formation of polar stratospheric clouds. Here, we present an update of the Polar SWIFT model introducing several improvements over the original model formulation. In particular, the model is now trained on vortex-averaged reaction rates of the ATLAS Chemistry and Transport Model, which enables a detailed look at individual processes and an independent validation of the different parameterizations contained in the differential equations. The training of the original Polar SWIFT model was based on fitting complete model runs to satellite observations and did not allow for this. A revised formulation of the system of differential equations is developed, which closely fits vortex-averaged reaction rates from ATLAS that represent the main chemical processes influencing ozone. In addition, a parameterization for the HNO3 change by denitrification is included. The rates of change of the concentrations of the chemical species of the Polar SWIFT model are purely chemical rates of change in the new version, whereas in the original Polar SWIFT model, they included a transport effect caused by the

  17. Nuclear physics with polarized particles

    CERN Document Server

    Paetz gen Schieck, Hans

    2012-01-01

    The measurement of spin-polarization observables in reactions of nuclei and particles is of great utility and advantage when the effects of single-spin sub-states are to be investigated. Indeed, the unpolarized differential cross-section encompasses the averaging over the spin states of the particles, and thus loses details of the interaction process. This introductory text combines, in a single volume, course-based lecture notes on spin physics and on polarized-ion sources with the aim of providing a concise yet self-contained starting point for newcomers to the field, as well as for lecturers in search of suitable material for their courses and seminars. A significant part of the book is devoted to introducing the formal theory-a description of polarization and of nuclear reactions with polarized particles. The remainder of the text describes the physical basis of methods and devices necessary to perform experiments with polarized particles and to measure polarization and polarization effects in nuclear rea...

  18. The formation and evolution of Titan’s winter polar vortex

    NARCIS (Netherlands)

    Teanby, Nicholas; Bezard, Bruno; Vinatier, Sandrine; Sylvestre, Melody; Nixon, Conor; Irwin, Patrick; de Kok, R.J.; Calcutt, Simon; Flasar, Michael

    2017-01-01

    Saturn’s largest moon Titan has a substantial nitrogen-methane atmosphere, with strong seasonal effects, including formation of winter polar vortices. Following Titan’s 2009 northern spring equinox, peak solar heating moved to the northern hemisphere, initiating south-polar subsidence and winter

  19. Polarization dynamics of unidirectional optical pulse evolution in a laser amplifier

    International Nuclear Information System (INIS)

    Zabolotskii, A. A.

    2007-01-01

    Polarization dynamics of optical pulses in an isotropic two-level medium is analyzed by solving an integrable system of evolution equations without using the slowly varying envelope approximation. The analysis is focused on the regime of unidirectional pulse generation in an initially inverted medium. Qualitative difference in polarization dynamics is revealed between few-cycle and quasi-monochromatic pulse propagation

  20. Anisotropies in cortical tension reveal the physical basis of polarizing cortical flows

    NARCIS (Netherlands)

    Mayer, M.; Depken, S.M.; Bois, J.S.; Julicher, M.; Grill, S.W.

    2010-01-01

    Asymmetric cell divisions are essential for the development of multicellular organisms. To proceed, they require an initially symmetric cell to polarize. In Caenorhabditis elegans zygotes, anteroposterior polarization is facilitated by a large-scale flow of the actomyosin cortex, which directs the

  1. Few-body experiments with polarized beams and polarized targets

    International Nuclear Information System (INIS)

    Simmons, J.E.

    1983-01-01

    A survey is presented concerning recent polarization experiments in the elastic p-d, p- 3 He, and p- 4 He systems. Mention is made of selected neutron experiments. The nominal energy range is 10 to 1000 MeV. Recent results and interpretations of the p-d system near 10 MeV are discussed. New experiments on the energy dependence of back angle p-d tensor polarization are discussed with respect to resolution of discrepancies and difficulty of theoretical interpretation. Progress is noted concerning multiple scattering interpretation of forward p-d deuteron polarization. Some new results are presented concerning the p- 3 He system and higher energy p- 4 He polarization experiments. 52 references

  2. On polar daily geomagnetic variation

    Directory of Open Access Journals (Sweden)

    Paola De Michelis

    2015-11-01

    Full Text Available The aim of this work is to investigate the nature of the daily magnetic field perturbations produced by ionospheric and magnetospheric currents at high latitudes. We analyse the hourly means of the X and Y geomagnetic field components recorded by a meridian chain of permanent geomagnetic observatories in the polar region of the Northern Hemisphere during a period of four years (1995-1998 around the solar minimum. We apply a mathematical method, known as natural orthogonal component (NOC, which is capable of characterizing the dominant modes of the geomagnetic field daily variability through a set of empirical orthogonal functions (EOFs. Using the first two modes we reconstruct a two-dimensional equivalent current representation of the ionospheric electric currents, which contribute substantially to the geomagnetic daily variations. The obtained current structures resemble the equivalent current patterns of DP2 and DP1. We characterize these currents by studying their evolution with the geomagnetic activity level and by analysing their dependence on the interplanetary magnetic field. The obtained results support the idea of a coexistence of two main processes during all analysed period although one of them, the directly driven process, represents the dominant component of the geomagnetic daily variation.

  3. The role of charged ice hydrometeors in lightning initiation

    DEFF Research Database (Denmark)

    Babich, L. P.; Bochkov, E. I.; Neubert, Torsten

    2017-01-01

    In connection with the lightning initiation problem, we consider positive streamer formation around charged, needle-shaped ice hydrometeors in an external electric field. We present results of numerical simulations of the streamer discharges that include the ice dielectric polarization and conduc......In connection with the lightning initiation problem, we consider positive streamer formation around charged, needle-shaped ice hydrometeors in an external electric field. We present results of numerical simulations of the streamer discharges that include the ice dielectric polarization...

  4. Elite Polarization and Public Opinion

    DEFF Research Database (Denmark)

    Robison, Joshua; Mullinix, Kevin

    2016-01-01

    Elite polarization has reshaped American politics and is an increasingly salient aspect of news coverage within the United States. As a consequence, a burgeoning body of research attempts to unravel the effects of elite polarization on the mass public. However, we know very little about how...... attitudes. In our first study, we show that criticism of polarization leads partisans to more positively evaluate the argument offered by their non-preferred party, increases support for bi-partisanship, but ultimately does not change the extent to which partisans follow their party’s policy endorsements...

  5. Acceleration of polarized proton beams

    International Nuclear Information System (INIS)

    Roser, T.

    1998-01-01

    The acceleration of polarized beams in circular accelerators is complicated by the numerous depolarizing spin resonances. Using a partial Siberian snake and a rf dipole that ensure stable adiabatic spin motion during acceleration has made it possible to accelerate polarized protons to 25 GeV at the Brookhaven AGS. Full Siberian snakes are being developed for RHIC to make the acceleration of polarized protons to 250 GeV possible. A similar scheme is being studied for the 800 GeV HERA proton accelerator

  6. Polarimetry with azimuthally polarized light

    Science.gov (United States)

    de Sande, Juan Carlos González; Piquero, Gemma; Santarsiero, Massimo

    2018-03-01

    Nonuniformly polarized light can be used for Mueller polarimetry of homogeneous linear samples. In this work, a set up based on using azimuthally polarized input light and a modified commercial light polarimeter is proposed and developed. With this set up, a Mueller submatrix of a sample can be obtained by measuring the Stokes parameters at only three different positions across the output beam section. Symmetry constraints for linear deterministic samples allow the complete Mueller matrix to be deduced for this kind of specimens. The experimental results obtained for phase plates and for a linear polarizer confirm the validity of the proposed method.

  7. Polarized deuteron elastic scattering from a polarized proton target

    International Nuclear Information System (INIS)

    Schmelzer, R.; Kuiper, H.; Schoeberl, M.; Berber, S.; Hilmert, H.; Koeppel, R.; Pferdmenges, R.; Zankel, H.

    1983-01-01

    Measurements are reported of the spin correlation parameter Cy,y for the elastic scattering of 10.0 MeV vector polarized deuterons from a polarized proton target at five CM angles (76 0 ,85 0 ,98 0 ,115 0 ,132 0 ). The experimental results are compared with different predictions. A Faddeev type calculation on the basis of local potentials also including approximate Coulomb distortion is favoured by our experimental results. (orig.)

  8. PolarHub: A Global Hub for Polar Data Discovery

    Science.gov (United States)

    Li, W.

    2014-12-01

    This paper reports the outcome of a NSF project in developing a large-scale web crawler PolarHub to discover automatically the distributed polar dataset in the format of OGC web services (OWS) in the cyberspace. PolarHub is a machine robot; its goal is to visit as many webpages as possible to find those containing information about polar OWS, extract this information and store it into the backend data repository. This is a very challenging task given huge data volume of webpages on the Web. Three unique features was introduced in PolarHub to make it distinctive from earlier crawler solutions: (1) a multi-task, multi-user, multi-thread support to the crawling tasks; (2) an extensive use of thread pool and Data Access Object (DAO) design patterns to separate persistent data storage and business logic to achieve high extendibility of the crawler tool; (3) a pattern-matching based customizable crawling algorithm to support discovery of multi-type geospatial web services; and (4) a universal and portable client-server communication mechanism combining a server-push and client pull strategies for enhanced asynchronous processing. A series of experiments were conducted to identify the impact of crawling parameters to the overall system performance. The geographical distribution pattern of all PolarHub identified services is also demonstrated. We expect this work to make a major contribution to the field of geospatial information retrieval and geospatial interoperability, to bridge the gap between data provider and data consumer, and to accelerate polar science by enhancing the accessibility and reusability of adequate polar data.

  9. Arabidopsis AIP1-2 restricted by WER-mediated patterning modulates planar polarity.

    Science.gov (United States)

    Kiefer, Christian S; Claes, Andrea R; Nzayisenga, Jean-Claude; Pietra, Stefano; Stanislas, Thomas; Hüser, Anke; Ikeda, Yoshihisa; Grebe, Markus

    2015-01-01

    The coordination of cell polarity within the plane of the tissue layer (planar polarity) is crucial for the development of diverse multicellular organisms. Small Rac/Rho-family GTPases and the actin cytoskeleton contribute to planar polarity formation at sites of polarity establishment in animals and plants. Yet, upstream pathways coordinating planar polarity differ strikingly between kingdoms. In the root of Arabidopsis thaliana, a concentration gradient of the phytohormone auxin coordinates polar recruitment of Rho-of-plant (ROP) to sites of polar epidermal hair initiation. However, little is known about cytoskeletal components and interactions that contribute to this planar polarity or about their relation to the patterning machinery. Here, we show that ACTIN7 (ACT7) represents a main actin isoform required for planar polarity of root hair positioning, interacting with the negative modulator ACTIN-INTERACTING PROTEIN1-2 (AIP1-2). ACT7, AIP1-2 and their genetic interaction are required for coordinated planar polarity of ROP downstream of ethylene signalling. Strikingly, AIP1-2 displays hair cell file-enriched expression, restricted by WEREWOLF (WER)-dependent patterning and modified by ethylene and auxin action. Hence, our findings reveal AIP1-2, expressed under control of the WER-dependent patterning machinery and the ethylene signalling pathway, as a modulator of actin-mediated planar polarity. © 2015. Published by The Company of Biologists Ltd.

  10. Openness initiative

    Energy Technology Data Exchange (ETDEWEB)

    Duncan, S.S. [Los Alamos National Lab., NM (United States)

    1995-12-31

    Although antinuclear campaigns seem to be effective, public communication and education efforts on low-level radioactive waste have mixed results. Attempts at public information programs on low-level radioactive waste still focus on influencing public opinion. A question then is: {open_quotes}Is it preferable to have a program focus on public education that will empower individuals to make informed decisions rather than trying to influence them in their decisions?{close_quotes} To address this question, a case study with both quantitative and qualitative data will be used. The Ohio Low-Level Radioactive Waste Education Program has a goal to provide people with information they want/need to make their own decisions. The program initiated its efforts by conducting a statewide survey to determine information needed by people and where they turned for that information. This presentation reports data from the survey and then explores the program development process in which programs were designed and presented using the information. Pre and post data from the programs reveal attitude and knowledge shifts.

  11. Tunable 13C/1H dual channel matching circuit for dynamic nuclear polarization system with cross-polarization

    DEFF Research Database (Denmark)

    Rybalko, Oleksandr; Bowen, Sean; Zhurbenko, Vitaliy

    2016-01-01

    In this paper we report initial results of design and practical implementation of tuning and matching circuit to estimate a performance of Dynamic Nuclear Polarization (DNP) at a magnetic field of 6.7 T. It is shown that developed circuit for signal observation is compact, easy to make and provides...

  12. Protecting polar wilderness : Just a western philosophical idea or a useful concept for regulating human activities in the polar regions?

    NARCIS (Netherlands)

    Bastmeijer, Kees; Leary, D.; Koivurova, T.; Alfredsson, G.

    2009-01-01

    Governments involved in Arctic and Antarctic governance have been well aware of the increasing human pressure on the Polar Regions and particularly the last two decades many initiatives have been taken to protect the Arctic and Antarctic environment. But what values are to be protected? This paper

  13. Health-related quality of life in adolescents with screening-detected celiac disease, before and one year after diagnosis and initiation of gluten-free diet, a prospective nested case-referent study

    Directory of Open Access Journals (Sweden)

    Nordyke Katrina

    2013-02-01

    Full Text Available Abstract Background Celiac disease (CD is a chronic disorder in genetically predisposed individuals in which a small intestinal immune-mediated enteropathy is precipitated by dietary gluten. It can be difficult to diagnose because signs and symptoms may be absent, subtle, or not recognized as CD related and therefore not prompt testing within routine clinical practice. Thus, most people with CD are undiagnosed and a public health intervention, which involves screening the general population, is an option to find those with unrecognized CD. However, how these screening-detected individuals experience the diagnosis and treatment (gluten-free diet is not fully understood. The aim of this study is to investigate the health-related quality of life (HRQoL of adolescents with screening-detected CD before and one year after diagnosis and treatment. Methods A prospective nested case-referent study was done involving Swedish adolescents who had participated in a CD screening study when they were in the sixth grade and about 12 years old. Screening-detected adolescents (n = 103 and referents without CD who participated in the same screening (n = 483 answered questionnaires at the time of the screening and approximately one year after the screening-detected adolescents had received their diagnosis that included the EQ-5D instrument used to measure health status and report HRQoL. Results The HRQoL for the adolescents with screening-detected CD is similar to the referents, both before and one year after diagnosis and initiation of the gluten-free diet, except in the dimension of pain at follow-up. In the pain dimension at follow-up, fewer cases reported problems than referents (12.6% and 21.9% respectively, Adjusted OR 0.50, 95% CI 0.27-0.94. However, a sex stratified analysis revealed that the significant difference was for boys at follow-up, where fewer screening-detected boys reported problems (4.3% compared to referent boys (18.8% (Adjusted OR 0

  14. Polarity Control in Group-III Nitrides beyond Pragmatism

    Science.gov (United States)

    Mohn, Stefan; Stolyarchuk, Natalia; Markurt, Toni; Kirste, Ronny; Hoffmann, Marc P.; Collazo, Ramón; Courville, Aimeric; Di Felice, Rosa; Sitar, Zlatko; Vennéguès, Philippe; Albrecht, Martin

    2016-05-01

    Controlling the polarity of polar semiconductors on nonpolar substrates offers a wealth of device concepts in the form of heteropolar junctions. A key to realize such structures is an appropriate buffer-layer design that, in the past, has been developed by empiricism. GaN or ZnO on sapphire are prominent examples for that. Understanding the basic processes that mediate polarity, however, is still an unsolved problem. In this work, we study the structure of buffer layers for group-III nitrides on sapphire by transmission electron microscopy as an example. We show that it is the conversion of the sapphire surface into a rhombohedral aluminum-oxynitride layer that converts the initial N-polar surface to Al polarity. With the various AlxOyNz phases of the pseudobinary Al2O3 -AlN system and their tolerance against intrinsic defects, typical for oxides, a smooth transition between the octahedrally coordinated Al in the sapphire and the tetrahedrally coordinated Al in AlN becomes feasible. Based on these results, we discuss the consequences for achieving either polarity and shed light on widely applied concepts in the field of group-III nitrides like nitridation and low-temperature buffer layers.

  15. The association between guideline-based treatment instructions at the point of discharge and lower 1-year mortality in Medicare patients after acute myocardial infarction: the American College of Cardiology's Guidelines Applied in Practice (GAP) initiative in Michigan.

    Science.gov (United States)

    Rogers, Adam M; Ramanath, Vijay S; Grzybowski, Mary; Riba, Arthur L; Jani, Sandeep M; Mehta, Rajendra; De Franco, Anthony C; Parrish, Robert; Skorcz, Stephen; Baker, Patricia L; Faul, Jessica; Chen, Benrong; Roychoudhury, Canopy; Elma, Mary Anne C; Mitchell, Kristi R; Froehlich, James B; Montoye, Cecelia; Eagle, Kim A

    2007-09-01

    The American College of Cardiology's Guidelines Applied in Practice (GAP) initiative for acute myocardial infarction (AMI) has been shown to increase the use of guideline-based therapies and improve outcomes in patients with AMI. It is unknown whether hospitals that are more successful in using the standard discharge contract--a key component of GAP that emphasizes guideline-based medications, lifestyle modification, and follow-up planning--experience a proportionally greater improvement in patient outcomes. Medicare patients treated for AMI in all 33 participating GAP hospitals in Michigan were enrolled. We aggregated the hospitals into 3 tertiles based on the rates of discharge contract use: 0% to 8.4% (tertile 1), >8.4% to 38.0% (tertile 2), and >38.0% to 61.1% (tertile 3). We analyzed 1-year follow-up mortality both pre- and post-GAP and compared the mortality decline post-GAP with discharge contract use according to tertile. There were 1368 patients in the baseline (pre-GAP) cohort and 1489 patients in the post-GAP cohort. After GAP implementation, mortality at 1 year decreased by 1.2% (P = .71), 1.2% (P = .68), and 6.0% (P = .03) for tertiles 1, 2, and 3, respectively. After multivariate adjustment, discharge contract use was significantly associated with decreased 1-year mortality in tertile 2 (odds ratio 0.43, 95% CI 0.22-0.84) and tertile 3 (odds ratio 0.45, 95% CI 0.27-0.75). Increased hospital utilization of the standard discharge contract as part of the GAP program is associated with decreased 1-year mortality in Medicare patient populations with AMI. Hospital efforts to promote adherence to guideline-based care tools such as the discharge contract used in GAP may result in mortality reductions for their patient populations at 1 year.

  16. Relationship between a Centers for Disease Control and Prevention expanded HIV testing initiative and past-year testing by race/ethnicity: a multilevel analysis of the Behavioral Risk Factor Surveillance System.

    Science.gov (United States)

    Gaines, Tommi L; Caldwell, Julia T; Ford, Chandra L; Mulatu, Mesfin S; Godette, Dionne C

    2016-01-01

    The Centers for Disease Control and Prevention's (CDC) expanded testing initiative (ETI) aims to bolster HIV testing among populations disproportionately affected by the HIV epidemic by providing additional funding to health departments serving these communities. ETI prioritizes testing in clinical settings; therefore, we examined the relationship between state-level ETI participation and past-year HIV testing among a racially/ethnically diverse sample of adult respondents to the 2012 Behavioral Risk Factor Surveillance System who accessed health services within the 12 months prior to being interviewed. Controlling for individual- and state-level characteristics in a multilevel logistic regression model, ETI participation was independently and positively associated with past-year testing, but this association varied by race/ethnicity. Hispanics had higher odds (adjusted odds ratio [AOR]: 1.49; 95% CI: 1.11-2.02) and American Indian/Alaska Natives had lower odds (AOR: 0.66; 95% CI: 0.43-0.99) of testing if they resided in states with (vs. without) ETI participation. State-level ETI participation did not significantly alter past-year testing among other racial/ethnic groups. Prioritizing public health resources in states most affected by HIV can improve testing patterns, but other mechanisms likely influence which racial/ethnic groups undergo testing.

  17. Polar source analysis : technical memorandum

    Science.gov (United States)

    2017-09-29

    The following technical memorandum describes the development, testing and analysis of various polar source data sets. The memorandum also includes recommendation for potential inclusion in future releases of AEDT. This memorandum is the final deliver...

  18. Anodic Concentration Polarization in SOFCs

    Energy Technology Data Exchange (ETDEWEB)

    Williford, Rick E.; Chick, Lawrence A.; Maupin, Gary D.; Simner, Steve P.; Stevenson, Jeffry W.; Khaleel, Mohammad A.; Wachsman, ED, et al

    2003-08-01

    Concentration polarization is important because it determines the maximum power output of a solid oxide fuel cell (SOFC) at high fuel utilization. Anodic concentration polarization occurs when the demand for reactants exceeds the capacity of the porous ceramic anode to supply them by gas diffusion mechanisms. High tortuosities (bulk diffusion resistances) are often assumed to explain this behavior. However, recent experiments show that anodic concentration polarization originates in the immediate vicinity of the reactive triple phase boundary (TPB) sites near the anode/electrolyte interface. A model is proposed to describe how concentration polarization is controlled by two localized phenomena: competitive adsorption of reactants in areas adjacent to the reactive TPB sites, followed by relatively slow surface diffusion to the reactive sites. Results suggest that future SOFC design improvements should focus on optimization of the reactive area, adsorption, and surface diffusion at the anode/electrolyte interface.

  19. The definition of cross polarization

    DEFF Research Database (Denmark)

    Ludwig, Arthur

    1973-01-01

    There are at least three different definitions of cross polarization used in the literature. The alternative definitions are discussed with respect to several applications, and the definition which corresponds to one standard measurement practice is proposed as the best choice....

  20. Polarization at LEP. Vol. 2

    International Nuclear Information System (INIS)

    Alexander, G.; Altarelli, G.; Blondel, A.; Coignet, G.; Keil, E.; Plane, D.E.; Treille, D.

    1988-01-01

    This report contains a collection of papers covering the most important part of studies carried out by five study groups in view of a programme of experiments with polarized beams at LEP, the Large Electron-Positron collider under construction at CERN. The emphasis is on precision measurements at the Z peak. Such measurements are shown to be of considerable theoretical interest as well as very clean from the point of view of theoretical and experimental uncertainties. The measurement of the beam polarization can certainly be performed with sufficient accuracy, thanks to the availability of both e + and e - beam polarization. The normalization of the data taken with different beam helicities poses certain constraints that are described. Substantial progress has been made in understanding the possibility of providing longitudinally polarized beams in the LEP machine: The design of new wigglers and spin rotators, the study of correction procedures and results of numerical simulations are presented. (orig.)