WorldWideScience

Sample records for pol ii occupancy

  1. Human RNA polymerase III transcriptomes and relationships to Pol II promoter chromatin and enhancer-binding factors.

    Science.gov (United States)

    Oler, Andrew J; Alla, Ravi K; Roberts, Douglas N; Wong, Alexander; Hollenhorst, Peter C; Chandler, Katherine J; Cassiday, Patrick A; Nelson, Cassie A; Hagedorn, Curt H; Graves, Barbara J; Cairns, Bradley R

    2010-05-01

    RNA polymerase (Pol) III transcribes many noncoding RNAs (for example, transfer RNAs) important for translational capacity and other functions. We localized Pol III, alternative TFIIIB complexes (BRF1 or BRF2) and TFIIIC in HeLa cells to determine the Pol III transcriptome, define gene classes and reveal 'TFIIIC-only' sites. Pol III localization in other transformed and primary cell lines reveals previously uncharacterized and cell type-specific Pol III loci as well as one microRNA. Notably, only a fraction of the in silico-predicted Pol III loci are occupied. Many occupied Pol III genes reside within an annotated Pol II promoter. Outside of Pol II promoters, occupied Pol III genes overlap with enhancer-like chromatin and enhancer-binding proteins such as ETS1 and STAT1. Moreover, Pol III occupancy scales with the levels of nearby Pol II, active chromatin and CpG content. These results suggest that active chromatin gates Pol III accessibility to the genome.

  2. The polycomb group mutant esc leads to augmented levels of paused Pol II in the Drosophila embryo.

    Science.gov (United States)

    Chopra, Vivek S; Hendrix, David A; Core, Leighton J; Tsui, Chiahao; Lis, John T; Levine, Michael

    2011-06-24

    Many developmental control genes contain paused RNA polymerase II (Pol II) and are thereby "poised" for rapid and synchronous activation in the early Drosophila embryo. Evidence is presented that Polycomb group (PcG) repressors can influence paused Pol II. ChIP-Seq and GRO-Seq assays were used to determine the genome-wide distributions of Pol II, H3K27me3, and H3K4me3 in extra sex combs (esc) mutant embryos. ESC is a key component of the Polycomb repressive complex 2 (PRC2), which mediates H3K27me3 modification. Enhanced Pol II occupancy is observed for thousands of genes in esc mutant embryos, including genes not directly regulated by PRC2. Thus, it would appear that silent genes lacking promoter-associated paused Pol II in wild-type embryos are converted into "poised" genes with paused Pol II in esc mutants. We suggest that this conversion of silent genes into poised genes might render differentiated cell types susceptible to switches in identity in PcG mutants. Copyright © 2011 Elsevier Inc. All rights reserved.

  3. Genome-wide dynamics of Pol II elongation and its interplay with promoter proximal pausing, chromatin, and exons

    NARCIS (Netherlands)

    Jonkers, Iris; Kwak, Hojoong; Lis, John T

    2014-01-01

    Production of mRNA depends critically on the rate of RNA polymerase II (Pol II) elongation. To dissect Pol II dynamics in mouse ES cells, we inhibited Pol II transcription at either initiation or promoter-proximal pause escape with Triptolide or Flavopiridol, and tracked Pol II kinetically using

  4. Involvement of specialized DNA polymerases Pol II, Pol IV and DnaE2 in DNA replication in the absence of Pol I in Pseudomonas putida

    International Nuclear Information System (INIS)

    Sidorenko, Julia; Jatsenko, Tatjana; Saumaa, Signe; Teras, Riho; Tark-Dame, Mariliis; Horak, Rita; Kivisaar, Maia

    2011-01-01

    The majority of bacteria possess a different set of specialized DNA polymerases than those identified in the most common model organism Escherichia coli. Here, we have studied the ability of specialized DNA polymerases to substitute Pol I in DNA replication in Pseudomonas putida. Our results revealed that P. putida Pol I-deficient cells have severe growth defects in LB medium, which is accompanied by filamentous cell morphology. However, growth of Pol I-deficient bacteria on solid rich medium can be restored by reduction of reactive oxygen species in cells. Also, mutants with improved growth emerge rapidly. Similarly to the initial Pol I-deficient P. putida, its adapted derivatives express a moderate mutator phenotype, which indicates that DNA replication carried out in the absence of Pol I is erroneous both in the original Pol I-deficient bacteria and the adapted derivatives. Analysis of the spectra of spontaneous Rif r mutations in P. putida strains lacking different DNA polymerases revealed that the presence of specialized DNA polymerases Pol II and Pol IV influences the frequency of certain base substitutions in Pol I-proficient and Pol I-deficient backgrounds in opposite ways. Involvement of another specialized DNA polymerase DnaE2 in DNA replication in Pol I-deficient bacteria is stimulated by UV irradiation of bacteria, implying that DnaE2-provided translesion synthesis partially substitutes the absence of Pol I in cells containing heavily damaged DNA.

  5. Involvement of specialized DNA polymerases Pol II, Pol IV and DnaE2 in DNA replication in the absence of Pol I in Pseudomonas putida

    Energy Technology Data Exchange (ETDEWEB)

    Sidorenko, Julia; Jatsenko, Tatjana; Saumaa, Signe; Teras, Riho; Tark-Dame, Mariliis; Horak, Rita [Department of Genetics, Institute of Molecular and Cell Biology, Tartu University and Estonian Biocentre, 23 Riia Street, 51010 Tartu (Estonia); Kivisaar, Maia, E-mail: maiak@ebc.ee [Department of Genetics, Institute of Molecular and Cell Biology, Tartu University and Estonian Biocentre, 23 Riia Street, 51010 Tartu (Estonia)

    2011-09-01

    The majority of bacteria possess a different set of specialized DNA polymerases than those identified in the most common model organism Escherichia coli. Here, we have studied the ability of specialized DNA polymerases to substitute Pol I in DNA replication in Pseudomonas putida. Our results revealed that P. putida Pol I-deficient cells have severe growth defects in LB medium, which is accompanied by filamentous cell morphology. However, growth of Pol I-deficient bacteria on solid rich medium can be restored by reduction of reactive oxygen species in cells. Also, mutants with improved growth emerge rapidly. Similarly to the initial Pol I-deficient P. putida, its adapted derivatives express a moderate mutator phenotype, which indicates that DNA replication carried out in the absence of Pol I is erroneous both in the original Pol I-deficient bacteria and the adapted derivatives. Analysis of the spectra of spontaneous Rif{sup r} mutations in P. putida strains lacking different DNA polymerases revealed that the presence of specialized DNA polymerases Pol II and Pol IV influences the frequency of certain base substitutions in Pol I-proficient and Pol I-deficient backgrounds in opposite ways. Involvement of another specialized DNA polymerase DnaE2 in DNA replication in Pol I-deficient bacteria is stimulated by UV irradiation of bacteria, implying that DnaE2-provided translesion synthesis partially substitutes the absence of Pol I in cells containing heavily damaged DNA.

  6. File list: Pol.Kid.10.RNA_polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.Kid.10.RNA_polymerase_II.AllCell hg19 RNA polymerase RNA polymerase II Kidney S...X1206068,SRX1206073,SRX1206074,SRX1206072,SRX1206071,SRX003882,SRX367323 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Pol.Kid.10.RNA_polymerase_II.AllCell.bed ...

  7. File list: Pol.Neu.20.RNA_polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.Neu.20.RNA_polymerase_II.AllCell hg19 RNA polymerase RNA polymerase II Neural S...6,SRX743838,SRX743832,SRX743834,SRX743840 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Pol.Neu.20.RNA_polymerase_II.AllCell.bed ...

  8. File list: Pol.Emb.10.RNA_polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.Emb.10.RNA_polymerase_II.AllCell dm3 RNA polymerase RNA polymerase II Embryo SR...7582,SRX050604,SRX050605,SRX013077 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/Pol.Emb.10.RNA_polymerase_II.AllCell.bed ...

  9. File list: Pol.Bon.20.RNA_polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.Bon.20.RNA_polymerase_II.AllCell hg19 RNA polymerase RNA polymerase II Bone SRX...,SRX351408 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Pol.Bon.20.RNA_polymerase_II.AllCell.bed ...

  10. File list: Pol.ALL.20.RNA_polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.ALL.20.RNA_polymerase_II.AllCell sacCer3 RNA polymerase RNA polymerase II All c...ell types http://dbarchive.biosciencedbc.jp/kyushu-u/sacCer3/assembled/Pol.ALL.20.RNA_polymerase_II.AllCell.bed ...

  11. File list: Pol.Neu.05.RNA_polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.Neu.05.RNA_polymerase_II.AllCell hg19 RNA polymerase RNA polymerase II Neural S...1,SRX099887,SRX099886,SRX743834,SRX743832 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Pol.Neu.05.RNA_polymerase_II.AllCell.bed ...

  12. File list: Pol.Oth.05.RNA_polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.Oth.05.RNA_polymerase_II.AllCell hg19 RNA polymerase RNA polymerase II Others S...RX1027435,SRX668218,SRX1027436,SRX1027434,SRX1027433,SRX099879,SRX099880 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Pol.Oth.05.RNA_polymerase_II.AllCell.bed ...

  13. File list: Pol.Kid.20.RNA_polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.Kid.20.RNA_polymerase_II.AllCell hg19 RNA polymerase RNA polymerase II Kidney S...SRX1206072,SRX1206066,SRX326423,SRX1206067,SRX003883,SRX003882,SRX367323 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Pol.Kid.20.RNA_polymerase_II.AllCell.bed ...

  14. File list: Pol.Bon.10.RNA_polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.Bon.10.RNA_polymerase_II.AllCell hg19 RNA polymerase RNA polymerase II Bone SRX...,SRX351408 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Pol.Bon.10.RNA_polymerase_II.AllCell.bed ...

  15. File list: Pol.Emb.05.RNA_polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.Emb.05.RNA_polymerase_II.AllCell dm3 RNA polymerase RNA polymerase II Embryo SR...7582,SRX013077,SRX050604,SRX050605 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/Pol.Emb.05.RNA_polymerase_II.AllCell.bed ...

  16. File list: Pol.Plc.50.RNA_polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.Plc.50.RNA_polymerase_II.AllCell hg19 RNA polymerase RNA polymerase II Placenta... http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Pol.Plc.50.RNA_polymerase_II.AllCell.bed ...

  17. File list: Pol.Kid.05.RNA_polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.Kid.05.RNA_polymerase_II.AllCell hg19 RNA polymerase RNA polymerase II Kidney S...SRX128201,SRX128200,SRX003882,SRX1206065,SRX1206066,SRX1206067,SRX367323 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Pol.Kid.05.RNA_polymerase_II.AllCell.bed ...

  18. File list: Pol.Gon.50.RNA_polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.Gon.50.RNA_polymerase_II.AllCell hg19 RNA polymerase RNA polymerase II Gonad ht...tp://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Pol.Gon.50.RNA_polymerase_II.AllCell.bed ...

  19. File list: Pol.Emb.20.RNA_polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.Emb.20.RNA_polymerase_II.AllCell ce10 RNA polymerase RNA polymerase II Embryo S...,SRX043869 http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/assembled/Pol.Emb.20.RNA_polymerase_II.AllCell.bed ...

  20. File list: Pol.Adp.50.RNA_polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.Adp.50.RNA_polymerase_II.AllCell hg19 RNA polymerase RNA polymerase II Adipocyt...e SRX682084,SRX682086,SRX682085,SRX682083 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Pol.Adp.50.RNA_polymerase_II.AllCell.bed ...

  1. File list: Pol.Epd.05.RNA_polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.Epd.05.RNA_polymerase_II.AllCell hg19 RNA polymerase RNA polymerase II Epidermi...245,SRX663247,SRX807622 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Pol.Epd.05.RNA_polymerase_II.AllCell.bed ...

  2. File list: Pol.Utr.05.RNA_polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.Utr.05.RNA_polymerase_II.AllCell hg19 RNA polymerase RNA polymerase II Uterus S...SRX573070,SRX027921,SRX1048949,SRX1136641,SRX1136638,SRX099217 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Pol.Utr.05.RNA_polymerase_II.AllCell.bed ...

  3. File list: Pol.CDV.10.RNA_polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.CDV.10.RNA_polymerase_II.AllCell hg19 RNA polymerase RNA polymerase II Cardiova...,SRX080152,SRX080153,SRX367018,SRX367016 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Pol.CDV.10.RNA_polymerase_II.AllCell.bed ...

  4. File list: Pol.Emb.05.RNA_polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.Emb.05.RNA_polymerase_II.AllCell ce10 RNA polymerase RNA polymerase II Embryo S...,SRX043867 http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/assembled/Pol.Emb.05.RNA_polymerase_II.AllCell.bed ...

  5. File list: Pol.Unc.10.RNA_polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.Unc.10.RNA_polymerase_II.AllCell hg19 RNA polymerase RNA polymerase II Unclassi...fied http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Pol.Unc.10.RNA_polymerase_II.AllCell.bed ...

  6. File list: Pol.YSt.20.RNA_polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.YSt.20.RNA_polymerase_II.AllCell sacCer3 RNA polymerase RNA polymerase II Yeast... strain http://dbarchive.biosciencedbc.jp/kyushu-u/sacCer3/assembled/Pol.YSt.20.RNA_polymerase_II.AllCell.bed ...

  7. File list: Pol.Emb.10.RNA_polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.Emb.10.RNA_polymerase_II.AllCell ce10 RNA polymerase RNA polymerase II Embryo S...,SRX043867 http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/assembled/Pol.Emb.10.RNA_polymerase_II.AllCell.bed ...

  8. File list: Pol.Emb.50.RNA_polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.Emb.50.RNA_polymerase_II.AllCell ce10 RNA polymerase RNA polymerase II Embryo S...,SRX043866 http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/assembled/Pol.Emb.50.RNA_polymerase_II.AllCell.bed ...

  9. File list: Pol.ALL.50.RNA_polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.ALL.50.RNA_polymerase_II.AllCell sacCer3 RNA polymerase RNA polymerase II All c...ell types http://dbarchive.biosciencedbc.jp/kyushu-u/sacCer3/assembled/Pol.ALL.50.RNA_polymerase_II.AllCell.bed ...

  10. File list: Pol.Myo.05.RNA_polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.Myo.05.RNA_polymerase_II.AllCell hg19 RNA polymerase RNA polymerase II Muscle h...ttp://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Pol.Myo.05.RNA_polymerase_II.AllCell.bed ...

  11. File list: Pol.Unc.05.RNA_polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.Unc.05.RNA_polymerase_II.AllCell hg19 RNA polymerase RNA polymerase II Unclassi...fied http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Pol.Unc.05.RNA_polymerase_II.AllCell.bed ...

  12. File list: Pol.Myo.20.RNA_polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.Myo.20.RNA_polymerase_II.AllCell hg19 RNA polymerase RNA polymerase II Muscle h...ttp://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Pol.Myo.20.RNA_polymerase_II.AllCell.bed ...

  13. File list: Pol.ALL.05.RNA_polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.ALL.05.RNA_polymerase_II.AllCell hg19 RNA polymerase RNA polymerase II All cell...,SRX1013886,SRX1013900 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Pol.ALL.05.RNA_polymerase_II.AllCell.bed ...

  14. File list: Pol.Liv.50.RNA_polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.Liv.50.RNA_polymerase_II.AllCell hg19 RNA polymerase RNA polymerase II Liver SR...1013886 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Pol.Liv.50.RNA_polymerase_II.AllCell.bed ...

  15. File list: Pol.Pup.05.RNA_polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.Pup.05.RNA_polymerase_II.AllCell dm3 RNA polymerase RNA polymerase II Pupae SRX...013069 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/Pol.Pup.05.RNA_polymerase_II.AllCell.bed ...

  16. File list: Pol.Dig.10.RNA_polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.Dig.10.RNA_polymerase_II.AllCell hg19 RNA polymerase RNA polymerase II Digestiv...//dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Pol.Dig.10.RNA_polymerase_II.AllCell.bed ...

  17. File list: Pol.Epd.50.RNA_polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.Epd.50.RNA_polymerase_II.AllCell hg19 RNA polymerase RNA polymerase II Epidermi...247,SRX080162,SRX807622 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Pol.Epd.50.RNA_polymerase_II.AllCell.bed ...

  18. File list: Pol.Bld.50.RNA_polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.Bld.50.RNA_polymerase_II.AllCell hg19 RNA polymerase RNA polymerase II Blood SR...,SRX153079,SRX017717,SRX103447,SRX386121,SRX038919,SRX038920,SRX080132 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Pol.Bld.50.RNA_polymerase_II.AllCell.bed ...

  19. File list: Pol.Pup.10.RNA_polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.Pup.10.RNA_polymerase_II.AllCell dm3 RNA polymerase RNA polymerase II Pupae SRX...013069 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/Pol.Pup.10.RNA_polymerase_II.AllCell.bed ...

  20. File list: Pol.Dig.05.RNA_polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.Dig.05.RNA_polymerase_II.AllCell hg19 RNA polymerase RNA polymerase II Digestiv...//dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Pol.Dig.05.RNA_polymerase_II.AllCell.bed ...

  1. File list: Pol.Kid.50.RNA_polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.Kid.50.RNA_polymerase_II.AllCell hg19 RNA polymerase RNA polymerase II Kidney S...SRX1206066,SRX1206067,SRX003882,SRX003883,SRX1206065,SRX367323,SRX326416 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Pol.Kid.50.RNA_polymerase_II.AllCell.bed ...

  2. File list: Pol.Pan.05.RNA_polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.Pan.05.RNA_polymerase_II.AllCell hg19 RNA polymerase RNA polymerase II Pancreas... SRX190244 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Pol.Pan.05.RNA_polymerase_II.AllCell.bed ...

  3. File list: Pol.ALL.05.RNA_polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.ALL.05.RNA_polymerase_II.AllCell sacCer3 RNA polymerase RNA polymerase II All c...ell types http://dbarchive.biosciencedbc.jp/kyushu-u/sacCer3/assembled/Pol.ALL.05.RNA_polymerase_II.AllCell.bed ...

  4. File list: Pol.Epd.10.RNA_polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.Epd.10.RNA_polymerase_II.AllCell hg19 RNA polymerase RNA polymerase II Epidermi...246,SRX663247,SRX807622 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Pol.Epd.10.RNA_polymerase_II.AllCell.bed ...

  5. File list: Pol.Gon.20.RNA_polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.Gon.20.RNA_polymerase_II.AllCell hg19 RNA polymerase RNA polymerase II Gonad ht...tp://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Pol.Gon.20.RNA_polymerase_II.AllCell.bed ...

  6. File list: Pol.CDV.20.RNA_polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.CDV.20.RNA_polymerase_II.AllCell hg19 RNA polymerase RNA polymerase II Cardiova...,SRX346933,SRX346936,SRX367018,SRX367016 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Pol.CDV.20.RNA_polymerase_II.AllCell.bed ...

  7. File list: Pol.Oth.20.RNA_polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.Oth.20.RNA_polymerase_II.AllCell hg19 RNA polymerase RNA polymerase II Others S...RX1027436,SRX1027435,SRX1027434,SRX1027433,SRX668218,SRX099880,SRX099879 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Pol.Oth.20.RNA_polymerase_II.AllCell.bed ...

  8. File list: Pol.Plc.05.RNA_polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.Plc.05.RNA_polymerase_II.AllCell hg19 RNA polymerase RNA polymerase II Placenta... http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Pol.Plc.05.RNA_polymerase_II.AllCell.bed ...

  9. File list: Pol.YSt.50.RNA_polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.YSt.50.RNA_polymerase_II.AllCell sacCer3 RNA polymerase RNA polymerase II Yeast... strain http://dbarchive.biosciencedbc.jp/kyushu-u/sacCer3/assembled/Pol.YSt.50.RNA_polymerase_II.AllCell.bed ...

  10. File list: Pol.ALL.05.RNA_polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.ALL.05.RNA_polymerase_II.AllCell dm3 RNA polymerase RNA polymerase II All cell ...013077,SRX050604,SRX050605 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/Pol.ALL.05.RNA_polymerase_II.AllCell.bed ...

  11. File list: Pol.Epd.20.RNA_polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.Epd.20.RNA_polymerase_II.AllCell hg19 RNA polymerase RNA polymerase II Epidermi...248,SRX663247,SRX807622 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Pol.Epd.20.RNA_polymerase_II.AllCell.bed ...

  12. File list: Pol.Emb.50.RNA_polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.Emb.50.RNA_polymerase_II.AllCell dm3 RNA polymerase RNA polymerase II Embryo SR...7582,SRX050604,SRX050605,SRX013073 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/Pol.Emb.50.RNA_polymerase_II.AllCell.bed ...

  13. File list: Pol.ALL.20.RNA_polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.ALL.20.RNA_polymerase_II.AllCell hg19 RNA polymerase RNA polymerase II All cell...0,SRX1013886,SRX016705 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Pol.ALL.20.RNA_polymerase_II.AllCell.bed ...

  14. File list: Pol.Adl.20.RNA_polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.Adl.20.RNA_polymerase_II.AllCell ce10 RNA polymerase RNA polymerase II Adult SR...SRX554718,SRX043965,SRX043963,SRX043964 http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/assembled/Pol.Adl.20.RNA_polymerase_II.AllCell.bed ...

  15. File list: Pol.Lar.05.RNA_polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  16. File list: Pol.Unc.50.RNA_polymerase_II.AllCell [Chip-atlas[Archive

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  17. File list: Pol.Unc.20.RNA_polymerase_II.AllCell [Chip-atlas[Archive

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  18. File list: Pol.Lng.20.RNA_polymerase_II.AllCell [Chip-atlas[Archive

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  19. File list: Pol.Plc.10.RNA_polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  20. File list: Pol.ALL.20.RNA_polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  8. File list: Pol.Adp.20.RNA_polymerase_II.AllCell [Chip-atlas[Archive

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  10. File list: Pol.Oth.20.RNA_Polymerase_II.AllCell [Chip-atlas[Archive

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  13. File list: Pol.Kid.20.RNA_Polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  14. File list: Pol.Emb.20.RNA_polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  15. File list: Pol.ALL.10.RNA_Polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  16. File list: Pol.Unc.05.RNA_Polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  17. File list: Pol.CDV.20.RNA_Polymerase_II.AllCell [Chip-atlas[Archive

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  18. File list: Pol.Adl.05.RNA_polymerase_II.AllCell [Chip-atlas[Archive

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  19. File list: Pol.Myo.10.RNA_Polymerase_II.AllCell [Chip-atlas[Archive

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  20. File list: Pol.Utr.05.RNA_Polymerase_II.AllCell [Chip-atlas[Archive

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  1. File list: Pol.Gon.05.RNA_polymerase_II.AllCell [Chip-atlas[Archive

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  2. File list: Pol.Epd.05.RNA_Polymerase_II.AllCell [Chip-atlas[Archive

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  3. File list: Pol.Lng.10.RNA_Polymerase_II.AllCell [Chip-atlas[Archive

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  4. File list: Pol.Oth.05.RNA_Polymerase_II.AllCell [Chip-atlas[Archive

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  5. File list: Pol.Spl.10.RNA_Polymerase_II.AllCell [Chip-atlas[Archive

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  6. File list: Pol.CDV.50.RNA_polymerase_II.AllCell [Chip-atlas[Archive

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  7. File list: Pol.Emb.50.RNA_Polymerase_II.AllCell [Chip-atlas[Archive

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  8. File list: Pol.Utr.50.RNA_Polymerase_II.AllCell [Chip-atlas[Archive

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  9. File list: Pol.Unc.20.RNA_Polymerase_II.AllCell [Chip-atlas[Archive

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  10. File list: Pol.Adp.50.RNA_Polymerase_II.AllCell [Chip-atlas[Archive

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  11. File list: Pol.Emb.05.RNA_Polymerase_II.AllCell [Chip-atlas[Archive

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  12. File list: Pol.YSt.10.RNA_polymerase_II.AllCell [Chip-atlas[Archive

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  13. File list: Pol.Lar.50.RNA_Polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.Lar.50.RNA_Polymerase_II.AllCell ce10 RNA polymerase RNA Polymerase II Larvae h...ttp://dbarchive.biosciencedbc.jp/kyushu-u/ce10/assembled/Pol.Lar.50.RNA_Polymerase_II.AllCell.bed ...

  14. Mitotic Transcriptional Activation: Clearance of Actively Engaged Pol II via Transcriptional Elongation Control in Mitosis.

    Science.gov (United States)

    Liang, Kaiwei; Woodfin, Ashley R; Slaughter, Brian D; Unruh, Jay R; Box, Andrew C; Rickels, Ryan A; Gao, Xin; Haug, Jeffrey S; Jaspersen, Sue L; Shilatifard, Ali

    2015-11-05

    Although it is established that some general transcription factors are inactivated at mitosis, many details of mitotic transcription inhibition (MTI) and its underlying mechanisms are largely unknown. We have identified mitotic transcriptional activation (MTA) as a key regulatory step to control transcription in mitosis for genes with transcriptionally engaged RNA polymerase II (Pol II) to activate and transcribe until the end of the gene to clear Pol II from mitotic chromatin, followed by global impairment of transcription reinitiation through MTI. Global nascent RNA sequencing and RNA fluorescence in situ hybridization demonstrate the existence of transcriptionally engaged Pol II in early mitosis. Both genetic and chemical inhibition of P-TEFb in mitosis lead to delays in the progression of cell division. Together, our study reveals a mechanism for MTA and MTI whereby transcriptionally engaged Pol II can progress into productive elongation and finish transcription to allow proper cellular division. Copyright © 2015 Elsevier Inc. All rights reserved.

  15. File list: Pol.NoD.50.RNA_polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.NoD.50.RNA_polymerase_II.AllCell sacCer3 RNA polymerase RNA polymerase II No de...scription http://dbarchive.biosciencedbc.jp/kyushu-u/sacCer3/assembled/Pol.NoD.50.RNA_polymerase_II.AllCell.bed ...

  16. File list: Pol.NoD.10.RNA_polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  17. File list: Pol.NoD.20.RNA_polymerase_II.AllCell [Chip-atlas[Archive

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  18. File list: Pol.NoD.20.RNA_polymerase_II.AllCell [Chip-atlas[Archive

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  19. File list: Pol.CeL.50.RNA_polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  20. File list: Pol.NoD.10.RNA_polymerase_II.AllCell [Chip-atlas[Archive

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  1. File list: Pol.NoD.50.RNA_polymerase_II.AllCell [Chip-atlas[Archive

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  2. File list: Pol.NoD.50.RNA_polymerase_II.AllCell [Chip-atlas[Archive

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  3. File list: Pol.NoD.05.RNA_polymerase_II.AllCell [Chip-atlas[Archive

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  4. File list: Pol.NoD.05.RNA_Polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  5. File list: Pol.NoD.10.RNA_Polymerase_II.AllCell [Chip-atlas[Archive

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  6. File list: Pol.NoD.05.RNA_Polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.NoD.05.RNA_Polymerase_II.AllCell sacCer3 RNA polymerase RNA Polymerase II No de...scription http://dbarchive.biosciencedbc.jp/kyushu-u/sacCer3/assembled/Pol.NoD.05.RNA_Polymerase_II.AllCell.bed ...

  7. Genome-wide dynamics of Pol II elongation and its interplay with promoter proximal pausing, chromatin, and exons.

    Science.gov (United States)

    Jonkers, Iris; Kwak, Hojoong; Lis, John T

    2014-04-29

    Production of mRNA depends critically on the rate of RNA polymerase II (Pol II) elongation. To dissect Pol II dynamics in mouse ES cells, we inhibited Pol II transcription at either initiation or promoter-proximal pause escape with Triptolide or Flavopiridol, and tracked Pol II kinetically using GRO-seq. Both inhibitors block transcription of more than 95% of genes, showing that pause escape, like initiation, is a ubiquitous and crucial step within the transcription cycle. Moreover, paused Pol II is relatively stable, as evidenced from half-life measurements at ∼3200 genes. Finally, tracking the progression of Pol II after drug treatment establishes Pol II elongation rates at over 1000 genes. Notably, Pol II accelerates dramatically while transcribing through genes, but slows at exons. Furthermore, intergenic variance in elongation rates is substantial, and is influenced by a positive effect of H3K79me2 and negative effects of exon density and CG content within genes.DOI: http://dx.doi.org/10.7554/eLife.02407.001. Copyright © 2014, Jonkers et al.

  8. Role of Mediator in Regulating Pol II Elongation and Nucleosome Displacement in Saccharomyces cerevisiae

    Science.gov (United States)

    Kremer, Selena B.; Kim, Sunyoung; Jeon, Jeong Ok; Moustafa, Yara W.; Chen, Apeng; Zhao, Jing; Gross, David S.

    2012-01-01

    Mediator is a modular multisubunit complex that functions as a critical coregulator of RNA polymerase II (Pol II) transcription. While it is well accepted that Mediator plays important roles in the assembly and function of the preinitiation complex (PIC), less is known of its potential roles in regulating downstream steps of the transcription cycle. Here we use a combination of genetic and molecular approaches to investigate Mediator regulation of Pol II elongation in the model eukaryote, Saccharomyces cerevisiae. We find that ewe (expression without heat shock element) mutations in conserved Mediator subunits Med7, Med14, Med19, and Med21—all located within or adjacent to the middle module—severely diminish heat-shock–induced expression of the Hsf1-regulated HSP82 gene. Interestingly, these mutations do not impede Pol II recruitment to the gene’s promoter but instead impair its transit through the coding region. This implies that a normal function of Mediator is to regulate a postinitiation step at HSP82. In addition, displacement of histones from promoter and coding regions, a hallmark of activated heat-shock genes, is significantly impaired in the med14 and med21 mutants. Suggestive of a more general role, ewe mutations confer hypersensitivity to the anti-elongation drug 6-azauracil (6-AU) and one of them—med21—impairs Pol II processivity on a GAL1-regulated reporter gene. Taken together, our results suggest that yeast Mediator, acting principally through its middle module, can regulate Pol II elongation at both heat-shock and non–heat-shock genes. PMID:22377631

  9. A large fraction of extragenic RNA pol II transcription sites overlap enhancers.

    Directory of Open Access Journals (Sweden)

    Francesca De Santa

    2010-05-01

    Full Text Available Mammalian genomes are pervasively transcribed outside mapped protein-coding genes. One class of extragenic transcription products is represented by long non-coding RNAs (lncRNAs, some of which result from Pol_II transcription of bona-fide RNA genes. Whether all lncRNAs described insofar are products of RNA genes, however, is still unclear. Here we have characterized transcription sites located outside protein-coding genes in a highly regulated response, macrophage activation by endotoxin. Using chromatin signatures, we could unambiguously classify extragenic Pol_II binding sites as belonging to either canonical RNA genes or transcribed enhancers. Unexpectedly, 70% of extragenic Pol_II peaks were associated with genomic regions with a canonical chromatin signature of enhancers. Enhancer-associated extragenic transcription was frequently adjacent to inducible inflammatory genes, was regulated in response to endotoxin stimulation, and generated very low abundance transcripts. Moreover, transcribed enhancers were under purifying selection and contained binding sites for inflammatory transcription factors, thus suggesting their functionality. These data demonstrate that a large fraction of extragenic Pol_II transcription sites can be ascribed to cis-regulatory genomic regions. Discrimination between lncRNAs generated by canonical RNA genes and products of transcribed enhancers will provide a framework for experimental approaches to lncRNAs and help complete the annotation of mammalian genomes.

  10. Observations on Occupation and Military Governance: An Analysis of the American Occupation of Japan and Germany in World War II

    National Research Council Canada - National Science Library

    Duray, Jr, Paul H

    2007-01-01

    Prior to the current Global War on Terror (GWOT), the United States military had not participated in occupation and military governance mission on as a massive a scale as that experienced in World War II...

  11. Competition of Escherichia coli DNA polymerases I, II and III with DNA Pol IV in stressed cells.

    Directory of Open Access Journals (Sweden)

    P J Hastings

    2010-05-01

    Full Text Available Escherichia coli has five DNA polymerases, one of which, the low-fidelity Pol IV or DinB, is required for stress-induced mutagenesis in the well-studied Lac frameshift-reversion assay. Although normally present at approximately 200 molecules per cell, Pol IV is recruited to acts of DNA double-strand-break repair, and causes mutagenesis, only when at least two cellular stress responses are activated: the SOS DNA-damage response, which upregulates DinB approximately 10-fold, and the RpoS-controlled general-stress response, which upregulates Pol IV about 2-fold. DNA Pol III was also implicated but its role in mutagenesis was unclear. We sought in vivo evidence on the presence and interactions of multiple DNA polymerases during stress-induced mutagenesis. Using multiply mutant strains, we provide evidence of competition of DNA Pols I, II and III with Pol IV, implying that they are all present at sites of stress-induced mutagenesis. Previous data indicate that Pol V is also present. We show that the interactions of Pols I, II and III with Pol IV result neither from, first, induction of the SOS response when particular DNA polymerases are removed, nor second, from proofreading of DNA Pol IV errors by the editing functions of Pol I or Pol III. Third, we provide evidence that Pol III itself does not assist with but rather inhibits Pol IV-dependent mutagenesis. The data support the remaining hypothesis that during the acts of DNA double-strand-break (DSB repair, shown previously to underlie stress-induced mutagenesis in the Lac system, there is competition of DNA polymerases I, II and III with DNA Pol IV for action at the primer terminus. Up-regulation of Pol IV, and possibly other stress-response-controlled factor(s, tilt the competition in favor of error-prone Pol IV at the expense of more accurate polymerases, thus producing stress-induced mutations. This mutagenesis assay reveals the DNA polymerases operating in DSB repair during stress and also

  12. Potent microRNA suppression by RNA Pol II-transcribed ‘Tough Decoy’ inhibitors

    Science.gov (United States)

    Bak, Rasmus O.; Hollensen, Anne Kruse; Primo, Maria Nascimento; Sørensen, Camilla Darum; Mikkelsen, Jacob Giehm

    2013-01-01

    MicroRNAs (miRNAs) are key regulators of gene expression and modulators of diverse biological pathways. Analyses of miRNA function as well as therapeutic managing of miRNAs rely on cellular administration of miRNA inhibitors which may be achieved by the use of viral vehicles. This study explores the miRNA-suppressive capacity of inhibitors expressed intracellularly from lentivirus-derived gene vectors. Superior activity of two decoy-type inhibitors, a “Bulged Sponge” with eight miRNA recognition sites and a hairpin-shaped “Tough Decoy” containing two miRNA recognition sites, is demonstrated in a side-by-side comparison of seven types of miRNA inhibitors transcribed as short RNAs from an RNA Pol III promoter. We find that lentiviral vectors expressing Tough Decoy inhibitors are less vulnerable than Bulged Sponge-encoding vectors to targeting by the cognate miRNA and less prone, therefore, to reductions in transfer efficiency. Importantly, it is demonstrated that Tough Decoy inhibitors retain their miRNA suppression capacity in the context of longer RNA transcripts expressed from an RNA Pol II promoter. Such RNA Pol II-transcribed Tough Decoy inhibitors are new tools in managing of miRNAs and may have potential for temporal and spatial regulation of miRNA activity as well as for therapeutic targeting of miRNAs that are aberrantly expressed in human disease. PMID:23249752

  13. Promoter2.0: for the recognition of PolII promoter sequences

    DEFF Research Database (Denmark)

    Knudsen, Steen; Knudsen, Steen

    1999-01-01

    Motivation : A new approach to the prediction of eukaryotic PolII promoters from DNA sequence takesadvantage of a combination of elements similar to neural networks and genetic algorithms to recognize a set ofdiscrete subpatterns with variable separation as one pattern: a promoter. The neural...... of optimization, the algorithm was able todiscriminate between vertebrate promoter and non-promoter sequences in a test set with a correlationcoefficient of 0.63. In addition, all five known transcription start sites on the plus strand of the completeadenovirus genome were within 161 bp of 35 predicted...... networks use as input a smallwindow of DNA sequence, as well as the output of other neural networks. Through the use of geneticalgorithms, the weights in the neural networks are optimized to discriminate maximally between promoters andnon-promoters. Results : After several thousand generations...

  14. Human Pol II promoter recognition based on primary sequences and free energy of dinucleotides

    Directory of Open Access Journals (Sweden)

    Yu Zu-Guo

    2008-02-01

    Full Text Available Abstract Background Promoter region plays an important role in determining where the transcription of a particular gene should be initiated. Computational prediction of eukaryotic Pol II promoter sequences is one of the most significant problems in sequence analysis. Existing promoter prediction methods are still far from being satisfactory. Results We attempt to recognize the human Pol II promoter sequences from the non-promoter sequences which are made up of exon and intron sequences. Four methods are used: two kinds of multifractal analysis performed on the numeric sequences obtained from the dinucleotide free energy, Z curve analysis and global descriptor of the promoter/non-promoter primary sequences. A total of 141 parameters are extracted from these methods and categorized into seven groups (methods. They are used to generate certain spaces and then each promoter/non-promoter sequence is represented by a point in the corresponding space. All the 120 possible combinations of the seven methods are tested. Based on Fisher's linear discriminant algorithm, with a relatively smaller number of parameters (96 and 117, we get satisfactory discriminant accuracies. Particularly, in the case of 117 parameters, the accuracies for the training and test sets reach 90.43% and 89.79%, respectively. A comparison with five other existing methods indicates that our methods have a better performance. Using the global descriptor method (36 parameters, 17 of the 18 experimentally verified promoter sequences of human chromosome 22 are correctly identified. Conclusion The high accuracies achieved suggest that the methods of this paper are useful for understanding the difficult problem of promoter prediction.

  15. RNA Pol II transcription model and interpretation of GRO-seq data.

    Science.gov (United States)

    Lladser, Manuel E; Azofeifa, Joseph G; Allen, Mary A; Dowell, Robin D

    2017-01-01

    A mixture model and statistical method is proposed to interpret the distribution of reads from a nascent transcriptional assay, such as global run-on sequencing (GRO-seq) data. The model is annotation agnostic and leverages on current understanding of the behavior of RNA polymerase II. Briefly, it assumes that polymerase loads at key positions (transcription start sites) within the genome. Once loaded, polymerase either remains in the initiation form (with some probability) or transitions into an elongating form (with the remaining probability). The model can be fit genome-wide, allowing patterns of Pol II behavior to be assessed on each distinct transcript. Furthermore, it allows for the first time a principled approach to distinguishing the initiation signal from the elongation signal; in particular, it implies a data driven method for calculating the pausing index, a commonly used metric that informs on the behavior of RNA polymerase II. We demonstrate that this approach improves on existing analyses of GRO-seq data and uncovers a novel biological understanding of the impact of knocking down the Male Specific Lethal (MSL) complex in Drosophilia melanogaster.

  16. Simon Thadeas Budek und Christoph Harant von Polžice unter den Alchemisten Kaiser Rudolfs II

    Czech Academy of Sciences Publication Activity Database

    Hausenblasová, J.; Purš, Ivo

    -, č. 9 (2009), s. 70-86 ISSN 1213-5372 Institutional research plan: CEZ:AV0Z80330511 Keywords : Simon Thadeas Budek * Christoph Harant of Polžice * Rudolf II * alchemy * history Subject RIV: AL - Art, Architecture, Cultural Heritage

  17. RNA Pol II promotes transcription of centromeric satellite DNA in beetles.

    Directory of Open Access Journals (Sweden)

    Zeljka Pezer

    Full Text Available Transcripts of centromeric satellite DNAs are known to play a role in heterochromatin formation as well as in establishment of the kinetochore. However, little is known about basic mechanisms of satellite DNA expression within constitutive heterochromatin and its regulation. Here we present comprehensive analysis of transcription of abundant centromeric satellite DNA, PRAT from beetle Palorus ratzeburgii (Coleoptera. This satellite is characterized by preservation and extreme sequence conservation among evolutionarily distant insect species. PRAT is expressed in all three developmental stages: larvae, pupae and adults at similar level. Transcripts are abundant comprising 0.033% of total RNA and are heterogeneous in size ranging from 0.5 kb up to more than 5 kb. Transcription proceeds from both strands but with 10 fold different expression intensity and transcripts are not processed into siRNAs. Most of the transcripts (80% are not polyadenylated and remain in the nucleus while a small portion is exported to the cytoplasm. Multiple, irregularly distributed transcription initiation sites as well as termination sites have been mapped within the PRAT sequence using primer extension and RLM-RACE. The presence of cap structure as well as poly(A tails in a portion of the transcripts indicate RNA polymerase II-dependent transcription and a putative polymerase II promoter site overlaps the most conserved part of the PRAT sequence. The treatment of larvae with alpha-amanitin decreases the level of PRAT transcripts at concentrations that selectively inhibit pol II activity. In conclusion, stable, RNA polymerase II dependant transcripts of abundant centromeric satellite DNA, not regulated by RNAi, have been identified and characterized. This study offers a basic understanding of expression of highly abundant heterochromatic DNA which in beetle species constitutes up to 50% of the genome.

  18. Human pol II promoter prediction: time series descriptors and machine learning.

    Science.gov (United States)

    Gangal, Rajeev; Sharma, Pankaj

    2005-01-01

    Although several in silico promoter prediction methods have been developed to date, they are still limited in predictive performance. The limitations are due to the challenge of selecting appropriate features of promoters that distinguish them from non-promoters and the generalization or predictive ability of the machine-learning algorithms. In this paper we attempt to define a novel approach by using unique descriptors and machine-learning methods for the recognition of eukaryotic polymerase II promoters. In this study, non-linear time series descriptors along with non-linear machine-learning algorithms, such as support vector machine (SVM), are used to discriminate between promoter and non-promoter regions. The basic idea here is to use descriptors that do not depend on the primary DNA sequence and provide a clear distinction between promoter and non-promoter regions. The classification model built on a set of 1000 promoter and 1500 non-promoter sequences, showed a 10-fold cross-validation accuracy of 87% and an independent test set had an accuracy >85% in both promoter and non-promoter identification. This approach correctly identified all 20 experimentally verified promoters of human chromosome 22. The high sensitivity and selectivity indicates that n-mer frequencies along with non-linear time series descriptors, such as Lyapunov component stability and Tsallis entropy, and supervised machine-learning methods, such as SVMs, can be useful in the identification of pol II promoters.

  19. Health Occupations Module. The Skeletal System--II.

    Science.gov (United States)

    Temple Univ., Philadelphia, PA. Div. of Vocational Education.

    This module on the skeletal system is one of eight modules designed for individualized instruction in health occupations education programs at both the secondary and postsecondary levels. This module contains an introduction to the module topic, two objectives (e.g., list the types of joints and movements, and give examples), and two learning…

  20. Oct-1, to go or not to go? That is the PolII question.

    Science.gov (United States)

    Pance, Alena

    2016-06-01

    The Oct transcription factors recognise an octamer DNA element from which they regulate transcription of specific target genes. Oct-1 is the only member of the subfamily that is ubiquitously expressed and has a wide role in transcriptional control. Through interaction with various partner proteins, Oct-1 can modulate accessibility to the chromatin to recruit the transcription machinery and form the pre-initiation complex. The recruited PolII is induced to initiate transcription and stalled until elongation is triggered on interaction with signalling transcription factors. In this way, Oct-1 can fulfil general roles in transcription by opening the chromatin as well as transduce extracellular signals by relaying activation through various interacting partners. The emerging picture of Oct-1 is that of a complex and versatile transcription factor with fundamental functions in cell homeostasis and signal response in general as well as cell specific contexts. This article is part of a Special Issue entitled: The Oct Transcription Factor Family, edited by Dr. Dean Tantin. Copyright © 2016 Elsevier B.V. All rights reserved.

  1. Kmt5a Controls Hepatic Metabolic Pathways by Facilitating RNA Pol II Release from Promoter-Proximal Regions.

    Science.gov (United States)

    Nikolaou, Kostas C; Moulos, Panagiotis; Harokopos, Vangelis; Chalepakis, George; Talianidis, Iannis

    2017-07-25

    H4K20 monomethylation maintains genome integrity by regulating proper mitotic condensation, DNA damage response, and replication licensing. Here, we show that, in non-dividing hepatic cells, H4K20Me1 is specifically enriched in active gene bodies and dynamically regulated by the antagonistic action of Kmt5a methylase and Kdm7b demethylase. In liver-specific Kmt5a-deficient mice, reduced levels of H4K20Me 1 correlated with reduced RNA Pol II release from promoter-proximal regions. Genes regulating glucose and fatty acid metabolism were most sensitive to impairment of RNA Pol II release. Downregulation of glycolytic genes resulted in an energy starvation condition partially compensated by AMP-activated protein kinase (AMPK) activation and increased mitochondrial activity. This metabolic reprogramming generated a highly sensitized state that, upon different metabolic stress conditions, quickly aggravated into a senescent phenotype due to ROS overproduction-mediated oxidative DNA damage. The results illustrate how defects in the general process of RNA Pol II transition into a productive elongation phase can trigger specific metabolic changes and genome instability. Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved.

  2. Kmt5a Controls Hepatic Metabolic Pathways by Facilitating RNA Pol II Release from Promoter-Proximal Regions

    Directory of Open Access Journals (Sweden)

    Kostas C. Nikolaou

    2017-07-01

    Full Text Available H4K20 monomethylation maintains genome integrity by regulating proper mitotic condensation, DNA damage response, and replication licensing. Here, we show that, in non-dividing hepatic cells, H4K20Me1 is specifically enriched in active gene bodies and dynamically regulated by the antagonistic action of Kmt5a methylase and Kdm7b demethylase. In liver-specific Kmt5a-deficient mice, reduced levels of H4K20Me1 correlated with reduced RNA Pol II release from promoter-proximal regions. Genes regulating glucose and fatty acid metabolism were most sensitive to impairment of RNA Pol II release. Downregulation of glycolytic genes resulted in an energy starvation condition partially compensated by AMP-activated protein kinase (AMPK activation and increased mitochondrial activity. This metabolic reprogramming generated a highly sensitized state that, upon different metabolic stress conditions, quickly aggravated into a senescent phenotype due to ROS overproduction-mediated oxidative DNA damage. The results illustrate how defects in the general process of RNA Pol II transition into a productive elongation phase can trigger specific metabolic changes and genome instability.

  3. Cell cycle dependent oscillatory expression of estrogen receptor-α links Pol II elongation to neoplastic transformation.

    Science.gov (United States)

    Vantaggiato, Cristina; Tocchetti, Marta; Cappelletti, Vera; Gurtner, Aymone; Villa, Alessandro; Daidone, Maria Grazia; Piaggio, Giulia; Maggi, Adriana; Ciana, Paolo

    2014-07-01

    Decades of studies provided a detailed view of the mechanism of estrogen receptor-α (ERα) regulated gene transcription and the physio-pathological relevance of the genetic programs controlled by this receptor in a variety of tissues. However, still limited is our knowledge on the regulation of ERα synthesis. Preliminary observations showed that the expression of ERα is cell cycle regulated. Here, we have demonstrated that a well described polymorphic sequence in the first intron of ERα (PvuII and XbaI) has a key role in regulating the ERα content in cycling cells. We have shown that the RNA Pol II (Pol II) elongation is blocked at the polymorphic site and that the proto-oncogene c-MYB modulates the release of the pausing polymerase. It is well known that the two SNPs are associated to an increased risk, progression, survival and mortality of endocrine-related cancers, here we have demonstrated that the c-MYB-dependent release of Pol II at a specific phase of the cell cycle is facilitated by the px haplotype, thus leading to a higher ERα mitogenic signal. In breast cancer, this mechanism is disrupted when the hormone refractory phenotype is established; therefore, we propose this oscillator as a novel target for the development of therapies aimed at sensitizing breast cancer resistant to hormonal treatments. Because PvuII and XbaI were associated to a broad range physio-pathological conditions beside neoplastic transformation, we expect that the ERα oscillator contributes to the regulation of the estrogen signal in several tissues.

  4. Pol II promoter prediction using characteristic 4-mer motifs: a machine learning approach.

    Science.gov (United States)

    Anwar, Firoz; Baker, Syed Murtuza; Jabid, Taskeed; Mehedi Hasan, Md; Shoyaib, Mohammad; Khan, Haseena; Walshe, Ray

    2008-10-04

    Eukaryotic promoter prediction using computational analysis techniques is one of the most difficult jobs in computational genomics that is essential for constructing and understanding genetic regulatory networks. The increased availability of sequence data for various eukaryotic organisms in recent years has necessitated for better tools and techniques for the prediction and analysis of promoters in eukaryotic sequences. Many promoter prediction methods and tools have been developed to date but they have yet to provide acceptable predictive performance. One obvious criteria to improve on current methods is to devise a better system for selecting appropriate features of promoters that distinguish them from non-promoters. Secondly improved performance can be achieved by enhancing the predictive ability of the machine learning algorithms used. In this paper, a novel approach is presented in which 128 4-mer motifs in conjunction with a non-linear machine-learning algorithm utilising a Support Vector Machine (SVM) are used to distinguish between promoter and non-promoter DNA sequences. By applying this approach to plant, Drosophila, human, mouse and rat sequences, the classification model has showed 7-fold cross-validation percentage accuracies of 83.81%, 94.82%, 91.25%, 90.77% and 82.35% respectively. The high sensitivity and specificity value of 0.86 and 0.90 for plant; 0.96 and 0.92 for Drosophila; 0.88 and 0.92 for human; 0.78 and 0.84 for mouse and 0.82 and 0.80 for rat demonstrate that this technique is less prone to false positive results and exhibits better performance than many other tools. Moreover, this model successfully identifies location of promoter using TATA weight matrix. The high sensitivity and specificity indicate that 4-mer frequencies in conjunction with supervised machine-learning methods can be beneficial in the identification of RNA pol II promoters comparative to other methods. This approach can be extended to identify promoters in sequences

  5. Pol II promoter prediction using characteristic 4-mer motifs: a machine learning approach

    Directory of Open Access Journals (Sweden)

    Shoyaib Mohammad

    2008-10-01

    Full Text Available Abstract Background Eukaryotic promoter prediction using computational analysis techniques is one of the most difficult jobs in computational genomics that is essential for constructing and understanding genetic regulatory networks. The increased availability of sequence data for various eukaryotic organisms in recent years has necessitated for better tools and techniques for the prediction and analysis of promoters in eukaryotic sequences. Many promoter prediction methods and tools have been developed to date but they have yet to provide acceptable predictive performance. One obvious criteria to improve on current methods is to devise a better system for selecting appropriate features of promoters that distinguish them from non-promoters. Secondly improved performance can be achieved by enhancing the predictive ability of the machine learning algorithms used. Results In this paper, a novel approach is presented in which 128 4-mer motifs in conjunction with a non-linear machine-learning algorithm utilising a Support Vector Machine (SVM are used to distinguish between promoter and non-promoter DNA sequences. By applying this approach to plant, Drosophila, human, mouse and rat sequences, the classification model has showed 7-fold cross-validation percentage accuracies of 83.81%, 94.82%, 91.25%, 90.77% and 82.35% respectively. The high sensitivity and specificity value of 0.86 and 0.90 for plant; 0.96 and 0.92 for Drosophila; 0.88 and 0.92 for human; 0.78 and 0.84 for mouse and 0.82 and 0.80 for rat demonstrate that this technique is less prone to false positive results and exhibits better performance than many other tools. Moreover, this model successfully identifies location of promoter using TATA weight matrix. Conclusion The high sensitivity and specificity indicate that 4-mer frequencies in conjunction with supervised machine-learning methods can be beneficial in the identification of RNA pol II promoters comparative to other methods. This

  6. Direct HPV E6/Myc interactions induce histone modifications, Pol II phosphorylation, and hTERT promoter activation

    Science.gov (United States)

    Chen, Renxiang; Dai, Yuhai; Schlegel, Richard; Liu, Xuefeng

    2017-01-01

    Human Papillomavirus Viruses (HPVs) are associated with the majority of human cervical and anal cancers and 10-30% of head and neck squamous carcinomas. E6 oncoprotein from high risk HPVs interacts with the p53 tumor suppressor protein to facilitate its degradation and increases telomerase activity for extending the life span of host cells. We published previously that the Myc cellular transcription factor associates with the high-risk HPV E6 protein in vivo and participates in the transactivation of the hTERT promoter. In the present study, we further analyzed the role of E6 and the Myc-Max-Mad network in regulating the hTERT promoter. We confirmed that E6 and Myc interact independently and that Max can also form a complex with E6. However, the E6/Max complex is observed only in the presence of Myc, suggesting that E6 associates with Myc/Max dimers. Consistent with the hypothesis that Myc is required for E6 induction of the hTERT promoter, Myc antagonists (Mad or Mnt) significantly blocked E6-mediated transactivation of the hTERT promoter. Analysis of Myc mutants demonstrated that both the transactivation domain and HLH domain of Myc protein were required for binding E6 and for the consequent transactivation of the hTERT promoter, by either Myc or E6. We also showed that E6 increased phosphorylation of Pol II on the hTERT promoter and induced epigenetic histone modifications of the hTERT promoter. More important, knockdown of Myc expression dramatically decreased engagement of acetyl-histones and Pol II at the hTERT promoter in E6-expressing cells. Thus, E6/Myc interaction triggers the transactivation of the hTERT promoter by modulating both histone modifications, Pol II phosphorylation and promoter engagement, suggesting a novel mechanism for telomerase activation and a new target for HPV- associated human cancer. PMID:29221209

  7. Los grandes, el poder y la cultura política de la nobleza en el reinado de Carlos II

    Directory of Open Access Journals (Sweden)

    Adolfo CARRASCO MARTÍNEZ

    2009-12-01

    Full Text Available RESUMEN: Este artículo se centra en los comportamientos políticos de la aristocracia española durante el reinado de Carlos II. Se estudian las actitudes colectivas del grupo y la evolución de la cultura política nobiliaria en el contexto de las profundas transformaciones que el ejercicio del poder experimentó en el periodo. Grandes y títulos hubieron de dar respuesta a la sucesión de escenarios políticos y, al mismo tiempo, influyeron decisivamente en la marcha de los asuntos. El progresivo deterioro de la autoridad regia determinó el paso a una poliarquía, a un modelo de múltiples centros de poder de equilibrios precarios que reflejaba el debate sobre el absolutismo y la participación política de la alta nobleza. Factores externos, como la cuestión sucesoria y la injerencia de las potencias extranjeras, y factores internos, como la incapacidad nobiliaria de cohesionarse en un proyecto común, la esperanza en liderazgos imposibles y las limitaciones de su cultura política, produjeron la rápida degeneración de la poliarquía en un régimen caótico en el crepúsculo del siglo XVII.ABSTRACT: This paper is focused on the political behaviour of the Spanish aristocracy under the reign of Charles II. It examines the group's general attitudes and the evolution of the noble political consciousness in a context where the exercise of power underwent deep changes. Grandees and titles had to react towards the series of political scenes and at the same time, they decisively had an influence over the course of events. The progressive impairment of the royal authority gave place to a polyarchy, a model of manifold control centres of precarious balance, which reflected the debate between the absolutism and the upper nobility's political concern. External factors, such as successory matters and foreign countries interference, and internal factors, like the noble inability to integrate themselves into a common project, the expectation around

  8. ChIP-seq and ChIP-exo profiling of Pol II, H2A.Z, and H3K4me3 in human K562 cells

    Science.gov (United States)

    McHaourab, Zenab F.; Perreault, Andrea A.; Venters, Bryan J.

    2018-03-01

    The human K562 chronic myeloid leukemia cell line has long served as an experimental paradigm for functional genomic studies. To systematically and functionally annotate the human genome, the ENCODE consortium generated hundreds of functional genomic data sets, such as chromatin immunoprecipitation coupled to sequencing (ChIP-seq). While ChIP-seq analyses have provided tremendous insights into gene regulation, spatiotemporal insights were limited by a resolution of several hundred base pairs. ChIP-exonuclease (ChIP-exo) is a refined version of ChIP-seq that overcomes this limitation by providing higher precision mapping of protein-DNA interactions. To study the interplay of transcription initiation and chromatin, we profiled the genome-wide locations for RNA polymerase II (Pol II), the histone variant H2A.Z, and the histone modification H3K4me3 using ChIP-seq and ChIP-exo. In this Data Descriptor, we present detailed information on parallel experimental design, data generation, quality control analysis, and data validation. We discuss how these data lay the foundation for future analysis to understand the relationship between the occupancy of Pol II and nucleosome positions at near base pair resolution.

  9. ChIP-seq and ChIP-exo profiling of Pol II, H2A.Z, and H3K4me3 in human K562 cells.

    Science.gov (United States)

    Mchaourab, Zenab F; Perreault, Andrea A; Venters, Bryan J

    2018-03-06

    The human K562 chronic myeloid leukemia cell line has long served as an experimental paradigm for functional genomic studies. To systematically and functionally annotate the human genome, the ENCODE consortium generated hundreds of functional genomic data sets, such as chromatin immunoprecipitation coupled to sequencing (ChIP-seq). While ChIP-seq analyses have provided tremendous insights into gene regulation, spatiotemporal insights were limited by a resolution of several hundred base pairs. ChIP-exonuclease (ChIP-exo) is a refined version of ChIP-seq that overcomes this limitation by providing higher precision mapping of protein-DNA interactions. To study the interplay of transcription initiation and chromatin, we profiled the genome-wide locations for RNA polymerase II (Pol II), the histone variant H2A.Z, and the histone modification H3K4me3 using ChIP-seq and ChIP-exo. In this Data Descriptor, we present detailed information on parallel experimental design, data generation, quality control analysis, and data validation. We discuss how these data lay the foundation for future analysis to understand the relationship between the occupancy of Pol II and nucleosome positions at near base pair resolution.

  10. Supervision of Occupational Therapy Level II Fieldwork Students: Impact on and Predictors of Clinician Productivity.

    Science.gov (United States)

    Ozelie, Rebecca; Janow, Janet; Kreutz, Corinne; Mulry, Mary Kate; Penkala, Ashley

    2015-01-01

    This study aimed to determine whether a difference in productivity exists between clinicians supervising and not supervising a Level II occupational therapy student and whether factors including clinician years of experience, practice setting, and clinician productivity without a student could predict clinician productivity while supervising a student. We used paired-sample t tests to examine clinician productivity with and without a student in 109 clinician-student encounters and regression analysis to determine factors predictive of clinician productivity with a student. Results indicated no difference in clinician productivity with or without a student. Clinician years of experience, practice area, and productivity without a student were significant predictors of clinician productivity while supervising a student. Study results contradict the belief that supervising Level II fieldwork students lowers clinicians' productivity. Findings suggest that practice area and productivity without a student are important factors influencing the productivity of clinicians supervising a fieldwork student. Copyright © 2015 by the American Occupational Therapy Association, Inc.

  11. Upgraded national occupational dose registry system - implementation of Phase-II programme

    International Nuclear Information System (INIS)

    Sanaye, S.S.; Baburajan, Sujatha; Johnson, Seethal; Nalawade, S.K.; Tudu, S.C.; Khedekar, B.M.; Sapra, B.K.; Datta, D.

    2016-01-01

    National Occupational Dose Registry System (NODRS) of Bhabha Atomic Research Centre maintains and updates occupational dose data of all monitored radiation workers in the country. The registry was upgraded in 2008 by establishing networked NODRS system through which personnel monitoring labs at different nuclear installations were networked with main dose registry server using the departmental ANUNET and NPCNET facilities. This has facilitated online allotment of personal numbers, storing of biometric information as well as providing online dose information to respective Health Physics Units (HPUs). On the basis of operational experience of NODRS and its feedback from users, Phase-II program was designed, developed and implemented. The paper gives an overview of implementation of this program at various sites

  12. Transcriptome kinetics is governed by a genome-wide coupling of mRNA production and degradation: a role for RNA Pol II.

    Directory of Open Access Journals (Sweden)

    Ophir Shalem

    2011-09-01

    Full Text Available Transcriptome dynamics is governed by two opposing processes, mRNA production and degradation. Recent studies found that changes in these processes are frequently coordinated and that the relationship between them shapes transcriptome kinetics. Specifically, when transcription changes are counter-acted with changes in mRNA stability, transient fast-relaxing transcriptome kinetics is observed. A possible molecular mechanism underlying such coordinated regulation might lay in two RNA polymerase (Pol II subunits, Rpb4 and Rpb7, which are recruited to mRNAs during transcription and later affect their degradation in the cytoplasm. Here we used a yeast strain carrying a mutant Pol II which poorly recruits these subunits. We show that this mutant strain is impaired in its ability to modulate mRNA stability in response to stress. The normal negative coordinated regulation is lost in the mutant, resulting in abnormal transcriptome profiles both with respect to magnitude and kinetics of responses. These results reveal an important role for Pol II, in regulation of both mRNA synthesis and degradation, and also in coordinating between them. We propose a simple model for production-degradation coupling that accounts for our observations. The model shows how a simple manipulation of the rates of co-transcriptional mRNA imprinting by Pol II may govern genome-wide transcriptome kinetics in response to environmental changes.

  13. Profiling Occupant Behaviour in Danish Dwellings using Time Use Survey Data - Part II: Time-related Factors and Occupancy

    DEFF Research Database (Denmark)

    Barthelmes, V.M.; Li, R.; Andersen, R.K.

    2018-01-01

    occupant profiles for prediction of energy use to reduce the gap between predicted and real building energy consumptions. In this study, we exploit diary-based Danish Time Use Surveys for understanding and modelling occupant behaviour in the residential sector in Denmark. This paper is a continuation......Occupant behaviour has been shown to be one of the key driving factors of uncertainty in prediction of energy consumption in buildings. Building occupants affect building energy use directly and indirectly by interacting with building energy systems such as adjusting temperature set......-points, switching lights on/off, using electrical devices and opening/closing windows. Furthermore, building inhabitants’ daily activity profiles clearly shape the timing of energy demand in households. Modelling energy-related human activities throughout the day, therefore, is crucial to defining more realistic...

  14. Specific interaction between DNA polymerase II (PolD) and RadB, a Rad51/Dmc1 homolog, in Pyrococcus furiosus.

    Science.gov (United States)

    Hayashi, I; Morikawa, K; Ishino, Y

    1999-12-15

    Pyrococcus furiosus has an operon containing the DNA polymerase II (PolD) gene and three other genes. Using a two-hybrid screening to examine the interactions of the proteins encoded by the operon, we identified a specific interaction between the second subunit of PolD (DP1) and a Rad51/Dmc1 homologous protein (RadB). To ensure the specific interaction between these two proteins, each gene in the operon was expressed in Escherichia coli or insect cells separately and the products were purified. The in vitro analyses using the purified proteins also showed the interaction between DP1 and RadB. The deletion mutant analysis of DP1 revealed that a region important for binding with RadB is located in the central part of the sequence (amino acid residues 206-498). This region has an overlap to the C-terminal half (amino acids 334-613), which is highly conserved among euryarchaeal DP1s and is essential for the activity of PolD. Our results suggest that, although RadB does not noticeably affect the primer extension ability of PolD in vitro, PolD may utilize the RadB protein in DNA synthesis under certain conditions.

  15. Arabidopsis Pol II-Dependent in Vitro Transcription System Reveals Role of Chromatin for Light-Inducible rbcS Gene Transcription1

    Science.gov (United States)

    Ido, Ayaka; Iwata, Shinya; Iwata, Yuka; Igarashi, Hisako; Hamada, Takahiro; Sonobe, Seiji; Sugiura, Masahiro; Yukawa, Yasushi

    2016-01-01

    In vitro transcription is an essential tool to study the molecular mechanisms of transcription. For over a decade, we have developed an in vitro transcription system from tobacco (Nicotiana tabacum)-cultured cells (BY-2), and this system supported the basic activities of the three RNA polymerases (Pol I, Pol II, and Pol III). However, it was not suitable to study photosynthetic genes, because BY-2 cells have lost their photosynthetic activity. Therefore, Arabidopsis (Arabidopsis thaliana) in vitro transcription systems were developed from green and etiolated suspension cells. Sufficient in vitro Pol II activity was detected after the minor modification of the nuclear soluble extracts preparation method; removal of vacuoles from protoplasts and L-ascorbic acid supplementation in the extraction buffer were particularly effective. Surprisingly, all four Arabidopsis Rubisco small subunit (rbcS-1A, rbcS-1B, rbcS-2B, and rbcS-3B) gene members were in vitro transcribed from the naked DNA templates without any light-dependent manner. However, clear light-inducible transcriptions were observed using chromatin template of rbcS-1A gene, which was prepared with a human nucleosome assembly protein 1 (hNAP1) and HeLa histones. This suggested that a key determinant of light-dependency through the rbcS gene transcription was a higher order of DNA structure (i.e. chromatin). PMID:26662274

  16. DNA damage regulates alternative splicing through changes in POL II elongation

    International Nuclear Information System (INIS)

    Munoz, M.J.; Perez Santangelo, M.S.; De la Mata, M.; Kornblihtt, A.R.

    2008-01-01

    Many apoptotic genes are regulated via alternative splicing (AS) but little is known about the mechanisms controlling AS in stress situations derived from DNA damage. Here we show that ultraviolet (UV) radiation affects co-transcriptional, but not post transcriptional, AS through a systemic mechanism involving a CDK-9-dependent hyper phosphorylation of RNA polymerase II carboxy terminal domain (CTD) and a subsequent and unprecedented inhibition of transcriptional elongation, estimated in vivo and in real time by FRAP. To mimic this hyper phosphorylation we used CTD mutants with serines 2 or 5 substituted by glutamic acids and found that they not only display lower elongation rates but duplicate the effects of UV light on AS in the absence of irradiation. Consistently, substitution of the serines with alanines prevents the UV effect on splicing. These results represent the first in vivo proof of modulation of elongation in response to an environmental signal, affecting in turn the kinetic coupling between transcription and splicing. (authors)

  17. Human leukocyte antigen class II variants and adult-onset asthma: does occupational allergen exposure play a role?

    NARCIS (Netherlands)

    Smit, L.A.M.; Strachan, D.P.; Vermeulen, R.; Bakker, P.I.W. de; Demenais, F.; Dumas, O.; Carsin, A.E.; Cullinan, P.; Curjuric, I.; Ghosh, R.E.; Heederik, D.; Imboden, M.; Jarvis, D.; Lathrop, M.; Moual, N. le; Mehta, A.; Miedinger, D.; Sigsgaard, T.; Siroux, V.; Vernez, D.; Zock, J.P.; Kauffmann, F.; Probst-Hensch, N.; Kogevinas, M.; Bouzigon, E.

    2014-01-01

    Recently, a locus centred on rs9273349 in the HLA-DQ region emerged from genome-wide association studies of adult-onset asthma. We aimed to further investigate the role of human leukocyte antigen (HLA) class II in adult-onset asthma and a possible interaction with occupational exposures. We imputed

  18. Human leukocyte antigen class II variants and adult-onset asthma : does occupational allergen exposure play a role?

    NARCIS (Netherlands)

    Smit, Lidwien A M; Strachan, David P; Vermeulen, Roel; de Bakker, Paul I W; Demenais, Florence; Dumas, Orianne; Carsin, Anne-Elie; Cullinan, Paul; Curjuric, Ivan; Ghosh, Rebecca E; Heederik, Dick; Imboden, Medea; Jarvis, Deborah; Lathrop, Mark; Le Moual, Nicole; Mehta, Amar; Miedinger, David; Sigsgaard, Torben; Siroux, Valérie; Vernez, David; Zock, Jan Paul; Kauffmann, Francine; Probst-Hensch, Nicole; Kogevinas, Manolis; Bouzigon, Emmanuelle

    2014-01-01

    Recently, a locus centred on rs9273349 in the HLA-DQ region emerged from genome-wide association studies of adult-onset asthma. We aimed to further investigate the role of human leukocyte antigen (HLA) class II in adult-onset asthma and a possible interaction with occupational exposures. We imputed

  19. O arco ocupacional saúde nas políticas de educação profissional The health occupational arch in the professional education policies

    Directory of Open Access Journals (Sweden)

    Neise Deluiz

    2013-08-01

    Full Text Available Este artigo tem como objetivo analisar as expectativas dos alunos em relação aos cursos de qualificação profissional do arco ocupacional saúde do Projovem Trabalhador no Rio de Janeiro, as concepções e estratégias pedagógicas utilizadas nos cursos e as mudanças ocorridas em sua situação social nas dimensões educacional, econômica, psicossocial e político-social. Trata-se de pesquisa qualitativa que utilizou grupos focais e entrevistas com os 58 alunos dos cursos. Na dimensão educacional, a qualificação profissional recebida foi insuficiente e não preparou os alunos para enfrentar os desafios do mercado de trabalho. A maioria continua buscando cursos como forma de aumentar as chances de trabalho. Na dimensão econômica, a maior parte dos jovens permaneceu desempregada, e na dimensão psicossocial observou-se referência às questões relativas à subjetividade, à autoestima, melhor comunicação e sociabilidade. Quanto à dimensão político-social, o maior ganho dos alunos foi na compreensão dos seus direitos como cidadãos, mas esta não os levou a atuar nos espaços da sociedade civil, como sindicatos e movimentos sociais. Conclui-se que as percepções dos alunos e os sentidos que atribuem ao Programa refletem as contradições da política, indicando que os jovens não são somente receptores passivos, mas sujeitos de direitos e protagonistas que reivindicam uma formação que atenda aos seus interesses.This article aims to analyze the students' expectations with regard to the vocational training courses provided under the "Projovem Trabalhador" occupational health arch, in Rio de Janeiro, the educational concepts and strategies used in the courses, and the changes that took place in their social situation in the educational, economic, psychosocial and socio-political dimensions. This is a qualitative study that used focus groups and interviews with 58 students of the courses. In the educational dimension, vocational

  20. O impacto dos efeitos da ocupação sobre a saúde de trabalhadores: II - Mortalidade The impact of occupation on worker's health: II - Mortality

    Directory of Open Access Journals (Sweden)

    René Mendes

    1988-10-01

    Full Text Available Foi realizada revisão bibliográfica analítica com o objetivo de quantificar o impacto dos efeitos da ocupação sobre a mortalidade de trabalhadores em suas implicações sobre o setor saúde. As repercussões sobre a mortalidade de trabalhadores são medidas através das mortes diretamente relacionadas com o trabalho (acidentes do trabalho fatais e intoxicações fatais e das indiretamente relacionadas. Partindo das grandes causas de morte entre adultos - doenças cardiovasculares, câncer e mortes violentas - e explorando as informações obtidas em estudos epidemiológicos realizados em outros países, estimou-se a força da contribuição da ocupação sobre a mortalidade. O peso e a complexidade das repercussões sobre o setor saúde pressupõem um desempenho mais ativo na definição de políticas e responsabilidades, e na organização de ações destinadas a identificar, reduzir ou eliminar a participação dos riscos ocupacionais nas grandes causas de doença e morte.An attempt to estimate the impact of occupation on worker's health was made as part of the rationale for the progressive integration of Occupational Health into the Health Sector. In this second study, based on a critical review of the literature, the repercussions on mortality are discussed on this basis analysis of the Brazilian data on deaths directly related to occupation (fatal occupational accidents and acute poisonings, as well as on those indirectly so related. The analysis of the major causes of adult deaths - cardiovascular diseases, cancer and violent deaths - compared with the proportion of "work-relatedness" according to several epidemiologic studies carried out in developed countries, make possible an estimation of the influence of the contribution of occupation on mortality. The size of this contribution is the main argument for an active involvement of the health sector in Occupational Health issues, because of the heavy toll in terms of adult morbidity

  1. Autoridades locales y partidos políticos en Andalucía durante la II República

    Directory of Open Access Journals (Sweden)

    OCTAVIO RUIZ MANJÓN

    1979-01-01

    Full Text Available Se presenta una tentativa de análisis del comportamiento de los gobernadores provinciales andaluces en su relación con las organizaciones políticas locales entre los años 1931 y 1936. Se establecen vínculos entre tales comportamientos y la sucesión de eventos políticos nacionales y locales. Para ello se emplea la información disponible en la Gaceta de Madrid (el órgano oficial español de la administración pública, así como recortes de la prensa local procedente de las ochos provincias andaluzas. Se analiza la estabilidad de los gobiernos en el ejercicio de sus responsabilidades mediante la comparación del promedio general presentado por cada provincia. Se comparan las fluctuaciones entre los porcentajes con las fluctuaciones generales que tienen lugar en la vida política en cada período considerado. Se concluye que la vida política local, su estructura organizativa y los sucesos que en ella acaecen tienen escasa influencia en la elección y estabilidad de los gobernantes.

  2. Instructional Support System--Occupational Education II. ISSOE Automotive Mechanics Content Validation.

    Science.gov (United States)

    Abramson, Theodore

    A study was conducted to validate the Instructional Support System-Occupational Education (ISSOE) automotive mechanics curriculum. The following four steps were undertaken: (1) review of the ISSOE materials in terms of their "validity" as task statements; (2) a comparison of the ISSOE tasks to the tasks included in the V-TECS Automotive…

  3. Allied Health Occupations II. Physical Therapy Aide Component. Student Learning Guide. Middletown Public Schools Curriculum Standards.

    Science.gov (United States)

    Middletown Public Schools, CT.

    This volume outlines the requirements and content of a second-year course in allied health occupations education that is designed to provide students with a practical understanding of the work done by physical therapists and physical therapy assistants. Addressed in the individual units of the course are the following topics: the health team for…

  4. Influence of education, marital status, occupation, and the place of living on skeletal status, fracture prevalence, and the course and effectiveness of osteoporotic therapy in women in the RAC-OST-POL Study.

    Science.gov (United States)

    Pluskiewicz, Wojciech; Adamczyk, Piotr; Czekajło, Aleksandra; Grzeszczak, Władysław; Drozdzowska, Bogna

    2014-01-01

    The RAC-OST-POL population-based, epidemiological study provided data concerning the influence of education, marital status, occupation, and the place of living (residence) on skeletal status, fracture prevalence, and the course and effectiveness of osteoporotic therapy in 625 women older than 55 years, all of them recruited from the District of Raciborz in Poland. Their mean age was 66.4 ± 7.8 years. All the women completed a specially designed questionnaire. The skeletal status was assessed by femoral neck (FN) and total hip (TH) densitometry, using a Lunar DPX system (USA). In univariate analyses, taking into consideration the age differences, bone mineralization was dependent on marital status (Z score for FN and TH was significantly higher in widows than in divorcees; p education was associated with a more frequent use of vitamin D (χ(2) = 8.49, df = 3, p women (30%) and least commonly by divorcees (11.8%) (χ(2) = 11.7, df = 3, p = 0.01). Vitamin D was more often used among women from the urban area of Raciborz than by those from surrounding rural areas (χ(2) = 9.2, df = 1, p Women with sedentary jobs demonstrated the highest frequency of intake for vitamin D (χ(2) = 9.92, df = 3, p education, marital status, place of living, and type of occupation may have impacts on implementation of osteoporosis-preventing health programs.

  5. Distribution of DRB1 and DQB1 HLA class II alleles in occupational asthma due to western red cedar.

    Science.gov (United States)

    Horne, C; Quintana, P J; Keown, P A; Dimich-Ward, H; Chan-Yeung, M

    2000-05-01

    Occupational asthma caused by western red cedar is a common problem in sawmill industries. The objective of this study was to examine a possible association of human leukocyte antigen (HLA) class II genetic markers with susceptibility or resistance to western red cedar induced asthma. The distribution of DRB1 and DQB1 HLA class II alleles and DRB1-DQB1 haplotypes was studied in 56 Caucasian patients with proven red cedar asthma and 63 healthy Caucasian control subjects exposed to red cedar dust. DRB1 and DQB1 high resolution typing was performed by the polymerase chain reaction-based method. Patients with red cedar asthma had a higher frequency of HLA DQB1*0603 and DQB1*0302 alleles compared to a group of healthy exposed control subjects and a reduced frequency of DQB1*0501 allele. The frequency of the DRB1*0401-DQB1* 0302 haplotype was increased and the DRB1*0101-DQB1*0501 haplotype was reduced. These findings suggest that genetic factors such as human leukocyte antigen class II antigens may be associated with susceptibility or resistance to development of red cedar asthma.

  6. The archaeology, chronology and stratigraphy of Madjedbebe (Malakunanja II): A site in northern Australia with early occupation.

    Science.gov (United States)

    Clarkson, Chris; Smith, Mike; Marwick, Ben; Fullagar, Richard; Wallis, Lynley A; Faulkner, Patrick; Manne, Tiina; Hayes, Elspeth; Roberts, Richard G; Jacobs, Zenobia; Carah, Xavier; Lowe, Kelsey M; Matthews, Jacqueline; Florin, S Anna

    2015-06-01

    Published ages of >50 ka for occupation at Madjedbebe (Malakunanja II) in Australia's north have kept the site prominent in discussions about the colonisation of Sahul. The site also contains one of the largest stone artefact assemblages in Sahul for this early period. However, the stone artefacts and other important archaeological components of the site have never been described in detail, leading to persistent doubts about its stratigraphic integrity. We report on our analysis of the stone artefacts and faunal and other materials recovered during the 1989 excavations, as well as the stratigraphy and depositional history recorded by the original excavators. We demonstrate that the technology and raw materials of the early assemblage are distinctive from those in the overlying layers. Silcrete and quartzite artefacts are common in the early assemblage, which also includes edge-ground axe fragments and ground haematite. The lower flaked stone assemblage is distinctive, comprising a mix of long convergent flakes, some radial flakes with faceted platforms, and many small thin silcrete flakes that we interpret as thinning flakes. Residue and use-wear analysis indicate occasional grinding of haematite and woodworking, as well as frequent abrading of platform edges on thinning flakes. We conclude that previous claims of extensive displacement of artefacts and post-depositional disturbance may have been overstated. The stone artefacts and stratigraphic details support previous claims for human occupation 50-60 ka and show that human occupation during this time differed from later periods. We discuss the implications of these new data for understanding the first human colonisation of Sahul. Copyright © 2015 Elsevier Ltd. All rights reserved.

  7. Responses to occupational and environmental exposures in the U.S. military--World War II to the present.

    Science.gov (United States)

    Richards, Erin E

    2011-07-01

    Since the Civil War, a proportion of U.S. service members continues to return from war with new health problems and continues to reference battlefield exposures as the cause. Hence, one of the most pressing public health debates in military policy, the determination of causality and linking of battlefield exposures to health outcomes in veterans, continues. The advances in military environmental and occupational epidemiologic research and Department of Defense policy concerning battlefield exposures are summarized and examples from World War II through the first Gulf War are provided. The limitations associated with the unique battlefield environment, multiple environmental exposures, and the inherent stresses of war, beget challenges for researchers responsible for determining causality. In light of these difficulties, six strategies for addressing environmental exposures and their possible impact on veterans were recommended by the Institute of Medicine post Operation Desert Storm. These strategies, along with their respective progress and remaining gaps, are addressed.

  8. [MATCHE: Management Approach to Teaching Consumer and Homemaking Education.] Occupational Strand: Management. Module II-F-2: Occupational Preparation for Jobs Utilizing Housekeeping Skills.

    Science.gov (United States)

    Karikka, Katherine

    This competency-based preservice home economics teacher education module on occupational preparation for jobs utilizing housekeeping skills is the second in a set of two modules on occupational programs related to home management. (This set is part of a larger set of sixty-seven modules on the Management Approach to Teaching Consumer and…

  9. Occupancy and Functional Architecture of the Pigment Binding Sites of Photosystem II Antenna Complex Lhcb5

    NARCIS (Netherlands)

    Ballottari, Matteo; Mozzo, Milena; Croce, Roberta; Morosinotto, Tomas; Bassi, Roberto

    2009-01-01

    Lhcb5 is an antenna protein that is highly conserved in plants and green algae. It is part of the inner layer of photosystem II antenna system retained in high light acclimated plants. To study the structure-function relation and the role of individual pigments in this complex, we (i) "knocked out"

  10. Pigment binding sites occupancy and functional architecture of the Photosystem II antenna complex Lhcb5

    NARCIS (Netherlands)

    Ballottari, M.; Mozzo, M.; Croce, R.; Morosinotto, T.; Bassi, R.

    2009-01-01

    Lhcb5 is an antenna protein that is highly conserved in plants and green algae. It is part of the inner layer of photosystem II antenna system retained in high light acclimated plants. To study the structure-function relation and the role of individual pigments in this complex, we (i) "knocked out"

  11. Redshift-space distortions with the halo occupation distribution - II. Analytic model

    Science.gov (United States)

    Tinker, Jeremy L.

    2007-01-01

    We present an analytic model for the galaxy two-point correlation function in redshift space. The cosmological parameters of the model are the matter density Ωm, power spectrum normalization σ8, and velocity bias of galaxies αv, circumventing the linear theory distortion parameter β and eliminating nuisance parameters for non-linearities. The model is constructed within the framework of the halo occupation distribution (HOD), which quantifies galaxy bias on linear and non-linear scales. We model one-halo pairwise velocities by assuming that satellite galaxy velocities follow a Gaussian distribution with dispersion proportional to the virial dispersion of the host halo. Two-halo velocity statistics are a combination of virial motions and host halo motions. The velocity distribution function (DF) of halo pairs is a complex function with skewness and kurtosis that vary substantially with scale. Using a series of collisionless N-body simulations, we demonstrate that the shape of the velocity DF is determined primarily by the distribution of local densities around a halo pair, and at fixed density the velocity DF is close to Gaussian and nearly independent of halo mass. We calibrate a model for the conditional probability function of densities around halo pairs on these simulations. With this model, the full shape of the halo velocity DF can be accurately calculated as a function of halo mass, radial separation, angle and cosmology. The HOD approach to redshift-space distortions utilizes clustering data from linear to non-linear scales to break the standard degeneracies inherent in previous models of redshift-space clustering. The parameters of the occupation function are well constrained by real-space clustering alone, separating constraints on bias and cosmology. We demonstrate the ability of the model to separately constrain Ωm,σ8 and αv in models that are constructed to have the same value of β at large scales as well as the same finger-of-god distortions at

  12. ENTROPY PRODUCTION IN COLLISIONLESS SYSTEMS. II. ARBITRARY PHASE-SPACE OCCUPATION NUMBERS

    International Nuclear Information System (INIS)

    Barnes, Eric I.; Williams, Liliya L. R.

    2012-01-01

    We present an analysis of two thermodynamic techniques for determining equilibria of self-gravitating systems. One is the Lynden-Bell (LB) entropy maximization analysis that introduced violent relaxation. Since we do not use the Stirling approximation, which is invalid at small occupation numbers, our systems have finite mass, unlike LB's isothermal spheres. (Instead of Stirling, we utilize a very accurate smooth approximation for ln x!.) The second analysis extends entropy production extremization to self-gravitating systems, also without the use of the Stirling approximation. In addition to the LB statistical family characterized by the exclusion principle in phase space, and designed to treat collisionless systems, we also apply the two approaches to the Maxwell-Boltzmann (MB) families, which have no exclusion principle and hence represent collisional systems. We implicitly assume that all of the phase space is equally accessible. We derive entropy production expressions for both families and give the extremum conditions for entropy production. Surprisingly, our analysis indicates that extremizing entropy production rate results in systems that have maximum entropy, in both LB and MB statistics. In other words, both thermodynamic approaches lead to the same equilibrium structures.

  13. Global gene expression analysis of fission yeast mutants impaired in Ser-2 phosphorylation of the RNA pol II carboxy terminal domain.

    Directory of Open Access Journals (Sweden)

    Reza Saberianfar

    Full Text Available In Schizosaccharomyces pombe the nuclear-localized Lsk1p-Lsc1p cyclin dependent kinase complex promotes Ser-2 phosphorylation of the heptad repeats found within the RNA pol II carboxy terminal domain (CTD. Here, we first provide evidence supporting the existence of a third previously uncharacterized Ser-2 CTD kinase subunit, Lsg1p. As expected for a component of the complex, Lsg1p localizes to the nucleus, promotes Ser-2 phosphorylation of the CTD, and physically interacts with both Lsk1p and Lsc1p in vivo. Interestingly, we also demonstrate that lsg1Δ mutants--just like lsk1Δ and lsc1Δ strains--are compromised in their ability to faithfully and reliably complete cytokinesis. Next, to address whether kinase mediated alterations in CTD phosphorylation might selectively alter the expression of genes with roles in cytokinesis and/or the cytoskeleton, global gene expression profiles were analyzed. Mutants impaired in Ser-2 phosphorylation display little change with respect to the level of transcription of most genes. However, genes affecting cytokinesis--including the actin interacting protein gene, aip1--as well as genes with roles in meiosis, are included in a small subset that are differentially regulated. Significantly, genetic analysis of lsk1Δ aip1Δ double mutants is consistent with Lsk1p and Aip1p acting in a linear pathway with respect to the regulation of cytokinesis.

  14. IX Congreso Nacional y II Congreso Internacional sobre Democracia: “Los senderos de la democracia en América Latina: Estado, Sociedad Civil y Cambio Político”. Rosario, Argentina, del 18 al 21 de octubre de 2010

    OpenAIRE

    Bartolacci, Franco

    2010-01-01

    Reseña del X Congreso Nacional y II Congreso Internacional sobre Democracia: “Los senderos de la democracia en América Latina: Estado, Sociedad Civil y Cambio Político” Rosario, Argentina, del 18 al 21 de octubre de 2010 Organizado por Facultad de Ciencia Política y Relaciones Internacionales de la Universidad Nacional de Rosario

  15. Live-cell Imaging of Pol II Promoter Activity to Monitor Gene expression with RNA IMAGEtag reporters

    Energy Technology Data Exchange (ETDEWEB)

    Shin, Ilchung [Ames Laboratory; Ray, Judhajeet [Ames Laboratory; Gupta, Vinayak [Iowa State University; Ilgu, Muslum [Ames Laboratory; Beasley, Jonathan [Iowa State University; Bendickson, Lee [Ames Laboratory; Mehanovic, Samir [Molecular Express; Kraus, George A. [Iowa State University; Nilsen-Hamilton, Marit [Ames Laboratory

    2014-04-20

    We describe a ribonucleic acid (RNA) reporter system for live-cell imaging of gene expression to detect changes in polymerase II activity on individual promoters in individual cells. The reporters use strings of RNA aptamers that constitute IMAGEtags (Intracellular MultiAptamer GEnetic tags) that can be expressed from a promoter of choice. For imaging, the cells are incubated with their ligands that are separately conjugated with one of the FRET pair, Cy3 and Cy5. The IMAGEtags were expressed in yeast from the GAL1, ADH1 or ACT1 promoters. Transcription from all three promoters was imaged in live cells and transcriptional increases from the GAL1 promoter were observed with time after adding galactose. Expression of the IMAGEtags did not affect cell proliferation or endogenous gene expression. Advantages of this method are that no foreign proteins are produced in the cells that could be toxic or otherwise influence the cellular response as they accumulate, the IMAGEtags are short lived and oxygen is not required to generate their signals. The IMAGEtag RNA reporter system provides a means of tracking changes in transcriptional activity in live cells and in real time.

  16. Inference of RNA polymerase II transcription dynamics from chromatin immunoprecipitation time course data.

    Directory of Open Access Journals (Sweden)

    Ciira wa Maina

    2014-05-01

    Full Text Available Gene transcription mediated by RNA polymerase II (pol-II is a key step in gene expression. The dynamics of pol-II moving along the transcribed region influence the rate and timing of gene expression. In this work, we present a probabilistic model of transcription dynamics which is fitted to pol-II occupancy time course data measured using ChIP-Seq. The model can be used to estimate transcription speed and to infer the temporal pol-II activity profile at the gene promoter. Model parameters are estimated using either maximum likelihood estimation or via Bayesian inference using Markov chain Monte Carlo sampling. The Bayesian approach provides confidence intervals for parameter estimates and allows the use of priors that capture domain knowledge, e.g. the expected range of transcription speeds, based on previous experiments. The model describes the movement of pol-II down the gene body and can be used to identify the time of induction for transcriptionally engaged genes. By clustering the inferred promoter activity time profiles, we are able to determine which genes respond quickly to stimuli and group genes that share activity profiles and may therefore be co-regulated. We apply our methodology to biological data obtained using ChIP-seq to measure pol-II occupancy genome-wide when MCF-7 human breast cancer cells are treated with estradiol (E2. The transcription speeds we obtain agree with those obtained previously for smaller numbers of genes with the advantage that our approach can be applied genome-wide. We validate the biological significance of the pol-II promoter activity clusters by investigating cluster-specific transcription factor binding patterns and determining canonical pathway enrichment. We find that rapidly induced genes are enriched for both estrogen receptor alpha (ERα and FOXA1 binding in their proximal promoter regions.

  17. Non-coding RNA derived from the region adjacent to the human HO-1 E2 enhancer selectively regulates HO-1 gene induction by modulating Pol II binding.

    Science.gov (United States)

    Maruyama, Atsushi; Mimura, Junsei; Itoh, Ken

    2014-12-16

    Recent studies have disclosed the function of enhancer RNAs (eRNAs), which are long non-coding RNAs transcribed from gene enhancer regions, in transcriptional regulation. However, it remains unclear whether eRNAs are involved in the regulation of human heme oxygenase-1 gene (HO-1) induction. Here, we report that multiple nuclear-enriched eRNAs are transcribed from the regions adjacent to two human HO-1 enhancers (i.e. the distal E2 and proximal E1 enhancers), and some of these eRNAs are induced by the oxidative stress-causing reagent diethyl maleate (DEM). We demonstrated that the expression of one forward direction (5' to 3') eRNA transcribed from the human HO-1 E2 enhancer region (named human HO-1enhancer RNA E2-3; hereafter called eRNA E2-3) was induced by DEM in an NRF2-dependent manner in HeLa cells. Conversely, knockdown of BACH1, a repressor of HO-1 transcription, further increased DEM-inducible eRNA E2-3 transcription as well as HO-1 expression. In addition, we showed that knockdown of eRNA E2-3 selectively down-regulated DEM-induced HO-1 expression. Furthermore, eRNA E2-3 knockdown attenuated DEM-induced Pol II binding to the promoter and E2 enhancer regions of HO-1 without affecting NRF2 recruitment to the E2 enhancer. These findings indicate that eRNAE2-3 is functional and is required for HO-1 induction. © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

  18. [Role of specialized care services of the national health service in the framework for the prevention of occupational risks (II)].

    Science.gov (United States)

    Gallo-Fernández, M

    Since 1986, the Government of Navarra has taken over the functions of security and health as part of the health 'area', with a broad conception of health, avoiding separating the citizen from the worker. In 1993, the Instituto Navarro de Salud Laboral created, under the direction of the departments of Health and Labor, combined diverse functions and resources, integrating preexisting structures into a technical department to be responsible for the overall health care of workers. The structure is based on two coordinated pillars, security and hygiene at work and occupational health. As more specifically to do with health, we describe the systems of epidemiological information and vigilance and programs for occupational disabilities, health activities in industry and investigation of diseases. The Unidades de Salud Laboral link the workplace with the public health service. The occupational health plan of Navarra will set out future strategies. It is necessary to involve neurologists in occupational health. Occupational risks and injury are everyone's problem. The neurologist's role in accidents is usually of health care; detection of illness is more difficult when an occupational relationship is not considered. Data from work should be included in the clinical history. The official figures for occupational neurological diseases are ridiculous and more cases should be detected. There should be a fluid relationship between neurologists, occupational doctors and experts in prevention.

  19. Transcription-factor occupancy at HOT regions quantitatively predicts RNA polymerase recruitment in five human cell lines.

    KAUST Repository

    Foley, Joseph W

    2013-10-20

    BACKGROUND: High-occupancy target (HOT) regions are compact genome loci occupied by many different transcription factors (TFs). HOT regions were initially defined in invertebrate model organisms, and we here show that they are a ubiquitous feature of the human gene-regulation landscape. RESULTS: We identified HOT regions by a comprehensive analysis of ChIP-seq data from 96 DNA-associated proteins in 5 human cell lines. Most HOT regions co-localize with RNA polymerase II binding sites, but many are not near the promoters of annotated genes. At HOT promoters, TF occupancy is strongly predictive of transcription preinitiation complex recruitment and moderately predictive of initiating Pol II recruitment, but only weakly predictive of elongating Pol II and RNA transcript abundance. TF occupancy varies quantitatively within human HOT regions; we used this variation to discover novel associations between TFs. The sequence motif associated with any given TF\\'s direct DNA binding is somewhat predictive of its empirical occupancy, but a great deal of occupancy occurs at sites without the TF\\'s motif, implying indirect recruitment by another TF whose motif is present. CONCLUSIONS: Mammalian HOT regions are regulatory hubs that integrate the signals from diverse regulatory pathways to quantitatively tune the promoter for RNA polymerase II recruitment.

  20. Occupational Clusters.

    Science.gov (United States)

    Pottawattamie County School System, Council Bluffs, IA.

    The 15 occupational clusters (transportation, fine arts and humanities, communications and media, personal service occupations, construction, hospitality and recreation, health occupations, marine science occupations, consumer and homemaking-related occupations, agribusiness and natural resources, environment, public service, business and office…

  1. Oct-2 forms a complex with Oct-1 on the iNOS promoter and represses transcription by interfering with recruitment of RNA PolII by Oct-1

    Science.gov (United States)

    Bentrari, Fatima; Chantôme, Aurelie; Knights, Andrew; Jeannin, Jean-François; Pance, Alena

    2015-01-01

    Oct-1 (POU2f1) and Oct-2 (POU2f2) are members of the POU family of transcription factors. They recognize the same DNA sequence but fulfil distinct functions: Oct-1 is ubiquitous and regulates a variety of genes while Oct-2 is restricted to B-cells and neurones. Here we examine the interplay and regulatory mechanisms of these factors to control the inducible nitric oxide synthase (iNOS, NOS2). Using two breast cancer cell lines as a comparative model, we found that MCF-7 express iNOS upon cytokine stimulation while MDA-MB-231 do not. Oct-1 is present in both cell lines but MDA-MB-231also express high levels of Oct-2. Manipulation of Oct-2 expression in these cell lines demonstrates that it is directly responsible for the repression of iNOS in MDA-MB-231. In MCF-7 cells Oct-1 binds the iNOS promoter, recruits RNA PolII and triggers initiation of transcription. In MDA-MB-231 cells, both Oct-1 and Oct-2 bind the iNOS promoter, forming a higher-order complex which fails to recruit RNA PolII, and as a consequence iNOS transcription does not proceed. Unravelling the mechanisms of transcription factor activity is paramount to the understanding of gene expression patterns that determine cell behaviour. PMID:26271992

  2. The Second Republic and the Civil War in the current political debate | La II República y la Guerra Civil en el debate político actual

    Directory of Open Access Journals (Sweden)

    Eduardo Sotillos Palet

    2007-12-01

    Full Text Available Seven decades on, the Second Republic and the civil war are still controversial topics that generate heated debate in numerous social groups, particularly among political parties and certain sectors of the media. Different individuals and groups express their sympathies towards either one of the two opposing factions. After the long years of silence imposed by Franco’s dictatorship, and once democracy had been firmly established in Spain, a powerful social movement emerged to vindicate the memory of those defeated in 1939, ignored and reviled by the Franco regime. | Después de setenta años, la II República y la Guerra Civil siguen siendo dos temas que generan un debate polémico en amplios sectores sociales, y en particular entre los partidos políticos y en determinados medios de comunicación. Unos y otros expresan sus simpatías hacia cada uno de los dos bandos en conflicto. Tras muchos años de silencio impuesto por la dictadura franquista y tras el proceso de transición a la democracia, y una vez que ésta está plena y sólidamente asentada, ha surgido un potente movimiento social que reivindica la memoria de los vencidos en 1939, ignorados y denostados por el franquismo.

  3. Spatial and Functional Relationships Among Pol V-Associated loci, Pol IV-Dependent siRNAs, and Cytosine Methylation in the Arabidopsis Epigenome

    Energy Technology Data Exchange (ETDEWEB)

    Wierzbicki, A. T.; Cocklin, Ross; Mayampurath, Anoop; Lister, Ryan; Rowley, M. J.; Gregory, Brian D.; Ecker, Joseph R.; Tang, Haixu; Pikaard, Craig S.

    2012-08-15

    Multisubunit RNA polymerases IV and V (Pols IV and V) mediate RNA-directed DNA methylation and transcriptional silencing of retrotransposons and heterochromatic repeats in plants. We identified genomic sites of Pol V occupancy in parallel with siRNA deep sequencing and methylcytosine mapping, comparing wild-type plants with mutants defective for Pol IV, Pol V, or both Pols IV and V. Approximately 60% of Pol V-associated regions encompass regions of 24-nucleotide (nt) siRNA complementarity and cytosine methylation, consistent with cytosine methylation being guided by base-pairing of Pol IV-dependent siRNAs with Pol V transcripts. However, 27% of Pol V peaks do not overlap sites of 24-nt siRNA biogenesis or cytosine methylation, indicating that Pol V alone does not specify sites of cytosine methylation. Surprisingly, the number of methylated CHH motifs, a hallmark of RNA-directed de novo methylation, is similar in wild-type plants and Pol IV or Pol V mutants. In the mutants, methylation is lost at 50%-60% of the CHH sites that are methylated in the wild type but is gained at new CHH positions, primarily in pericentromeric regions. These results indicate that Pol IV and Pol V are not required for cytosine methyltransferase activity but shape the epigenome by guiding CHH methylation to specific genomic sites.

  4. Morfologia do polén anemófilo e alergizante no Brasil: II. Polygonaceae, Amaranthaceae, Chenopodiaceae, Leguminosae, Euphorbiaceae e Myrtaceae

    Directory of Open Access Journals (Sweden)

    Ortrud Monika Barth

    1976-01-01

    Full Text Available Em continuação à primeira parte deste catálogo (Barth et al., 1975, é estudada a morfologia dos grãos de polén das espécies anemófilas pertencentes às famílias Polygonaceae, Amaranthaceae, Chenopodiaceae, Leguminosae, Euphorbiaceae e Myrta ceae, cujo conhecimento interessa a estudos relacionados à poluição atmosférica e a processos alérgicos, especialmente das vias respiratórias.In continuation to the first part of this catalogue (Barth et al., 1975, the morphology of the pollen grains of the anemophilous species of six additional families is studied, their correct identification being relevant to studies concerning air pollution and allergic processes, chiefly of the respiratory tract.

  5. A Crisis Framework Applied to Macrosociological Family Changes: Marriage, Divorce, and Occupational Trends Associated with World War II

    Science.gov (United States)

    Lipman-Blumen, Jean

    1975-01-01

    A typology of crises is developed to be used with critical aspects of the social system to predict both crisis and postcrisis period role changes. The crisis framework is then applied to macro-changes in family structure in response to an archetypal crisis, World War II. Census data generally support the hypotheses. (Author)

  6. La cultura política del ciudadano y la comunicación política en TV en la transición política del plebiscito chileno (octubre 1988. I. Metodología. II. Conclusiones

    Directory of Open Access Journals (Sweden)

    JOSÉ LUIS PIÑUEL RAIGADA

    1990-01-01

    Full Text Available Exposición de la acotación material y formal del objeto al que se destina la investigación realizada, y cuyo campo de observación es la situación histórica brindada con la campaña política del plebiscito chileno del 5 de octubre de 1988. La prefiguración teórica de este objeto es la responsable de la selección y consistencia de los datos que se han recolectado y procesado, y la que ha motivado a escoger como campo de observación la COMUNICACIÓN POLÍTICA televisiva y la CULTURA POLÍTICA del ciudadano en el Chile Plebiscitario. De la investigación se concluye que la Mediación comunicativa del Plebiscito ha implantado en la Transición chilena un proceso de resignificación cuyo sentido radica más en la "afirmación del cambio" que en la "afirmación de opciones contra", curiosamente ligadas estas últimas, por la vía de la comunicación, a la opción política cuya práctica no era de cambio, sino de continuidad.

  7. Genome-wide profiling of PPARgamma:RXR and RNA polymerase II occupancy reveals temporal activation of distinct metabolic pathways and changes in RXR dimer composition during adipogenesis

    DEFF Research Database (Denmark)

    Nielsen, Ronni; Pedersen, Thomas Askov; Hagenbeek, Dik

    2008-01-01

    in adipocytes and show that during early stages of differentiation, many of these are preoccupied by non-PPARgamma RXR-heterodimers. Different temporal and compositional patterns of occupancy are observed. In addition, we detect co-occupancy with members of the C/EBP family. Analysis of RNAPII occupancy...

  8. The importance of occupancy rather than affinity of CaVβ subunits for the calcium channel I–II linker in relation to calcium channel function

    Science.gov (United States)

    Butcher, Adrian J; Leroy, Jérôme; Richards, Mark W; Pratt, Wendy S; Dolphin, Annette C

    2006-01-01

    The CaVβ subunits of voltage-gated calcium channels regulate the trafficking and biophysical properties of these channels. We have taken advantage of mutations in the tyrosine residue within the alpha interaction domain (AID) in the I–II linker of CaV2.2 which reduce, but do not abolish, the binding of β1b to the AID of CaV2.2. We have found that the mutation Y388S decreased the affinity of CaVβ1b binding to the CaV2.2 I–II linker from 14 to 329 nm. However, the Y388S mutation had no effect on current density and cell surface expression of CaV2.2/α2δ-2/β1b channels expressed in human embryonic kidney tsA-201 cells, when equivalent proportions of cDNA were used. Furthermore, despite the 24-fold reduced affinity of CaVβ1b for the Y388S I–II linker of CaV2.2, all the key features of modulation as well as trafficking by CaVβ subunits remained intact. This is in contrast to the much more marked effect of the W391A mutation, which abolished interaction with the CaV2.2 I–II linker, and very markedly affected the trafficking of the channels. However, using the Xenopus oocyte expression system, where expression levels can be accurately titrated, when CaVβ1b cDNA was diluted 50-fold, all evidence of interaction with CaV2.2 Y388S was lost, although wild-type CaV2.2 was still normally modulated by the reduced concentration of β1b. These results indicate that high affinity interaction with the α1 subunit is not necessary for any of the modulatory effects of CaVβ subunits, but occupancy of the interaction site is important, and this will occur, despite the reduced affinity, if the CaVβ subunit is present in sufficient excess. PMID:16627564

  9. The importance of occupancy rather than affinity of CaV(beta) subunits for the calcium channel I-II linker in relation to calcium channel function.

    Science.gov (United States)

    Butcher, Adrian J; Leroy, Jérôme; Richards, Mark W; Pratt, Wendy S; Dolphin, Annette C

    2006-07-15

    The Ca(V)beta subunits of voltage-gated calcium channels regulate the trafficking and biophysical properties of these channels. We have taken advantage of mutations in the tyrosine residue within the alpha interaction domain (AID) in the I-II linker of Ca(V)2.2 which reduce, but do not abolish, the binding of beta1b to the AID of Ca(V)2.2. We have found that the mutation Y388S decreased the affinity of Ca(V)beta1b binding to the Ca(V)2.2 I-II linker from 14 to 329 nm. However, the Y388S mutation had no effect on current density and cell surface expression of Ca(V)2.2/alpha2delta-2/beta1b channels expressed in human embryonic kidney tsA-201 cells, when equivalent proportions of cDNA were used. Furthermore, despite the 24-fold reduced affinity of Ca(V)beta1b for the Y388S I-II linker of Ca(V)2.2, all the key features of modulation as well as trafficking by Ca(V)beta subunits remained intact. This is in contrast to the much more marked effect of the W391A mutation, which abolished interaction with the Ca(V)2.2 I-II linker, and very markedly affected the trafficking of the channels. However, using the Xenopus oocyte expression system, where expression levels can be accurately titrated, when Ca(V)beta1b cDNA was diluted 50-fold, all evidence of interaction with Ca(V)2.2 Y388S was lost, although wild-type Ca(V)2.2 was still normally modulated by the reduced concentration of beta1b. These results indicate that high affinity interaction with the alpha1 subunit is not necessary for any of the modulatory effects of Ca(V)beta subunits, but occupancy of the interaction site is important, and this will occur, despite the reduced affinity, if the Ca(V)beta subunit is present in sufficient excess.

  10. Síntese, caracterização e estudo das propriedades magnéticas de um polímero de coordenação contendo cobalto(II e cobre(II

    Directory of Open Access Journals (Sweden)

    Tamyris T. da Cunha

    2012-01-01

    Full Text Available This work describes the synthesis and characterization of two new compounds with ligand opy (N-(2-pyridyloxamate: the copper(II precursor [Me4N]2[Cu(opy2].5H2O and CoII CuII coordination polymer {[CoCu(opy2]}n×4nH2O. This latter compound was obtained by reaction of [Me4N]2[Cu(opy2].5H2O and CoCl2.6H2O in water. The heterobimetallic CoII CuII chain was characterized by elemental analysis, IR spectroscopy, thermogravimetry and magnetic measurements. Magnetic characterization revealed typical behavior of one-dimensional (1D ferrimagnetic chain as shown in the curves of temperature (T dependence of magnetic susceptibility (χM, in the form of χMT versus T, and dependence of magnetization (M with applied field (H.

  11. Translesion DNA polymerases Pol ζ, Pol η, Pol ι, Pol κ and Rev1 are ...

    Indian Academy of Sciences (India)

    MADU

    Kozmin S G, Pavlov Y I, Kunkel T A and Sage E 2003 Roles of Saccharomyces cerevisiae DNA polymerases Pol η and. Pol ζ in response to simulated sunlight; Nucleic Acids Res. 31. 4541–4552. Lawrence C W 2002 Cellular roles of DNA polymerase ζ and Rev. 1 protein; DNA Repair 1 425–435. Lemontt J F 1971 Mutants ...

  12. Streptococcus suis: a re-emerging pathogen associated with occupational exposure to pigs or pork products. Part II - Pathogenesis.

    Science.gov (United States)

    Dutkiewicz, Jacek; Zając, Violetta; Sroka, Jacek; Wasiński, Bernard; Cisak, Ewa; Sawczyn, Anna; Kloc, Anna; Wójcik-Fatla, Angelina

    2018-03-14

    Streptococcus suis is a re-emerging zoonotic pathogen that may cause severe disease, mostly meningitis, in pigs and in humans having occupational contact with pigs and pork, such as farmers, slaughterhose workers and butchers. The first stage of the pathogenic process, similar in pigs and humans, is adherence to and colonisation of mucosal and/or epithelial surface(s) of the host. The second stage is invasion into deeper tissue and extracellular translocation of bacterium in the bloodstream, either free in circulation or attached to the surface of monocytes. If S. suis present in blood fails to cause fatal septicaemia, it is able to progress into the third stage comprising penetration into host's organs, mostly by crossing the blood-brain barrier and/or blood-cerebrospinal fluid barrier to gain access to the central nervous system (CNS) and cause meningitis. The fourth stage is inflammation that plays a key role in the pathogen esis of both systemic and CNS infections caused by S. suis. The pathogen may induce the overproduction of pro-inflammatory cytokines that cause septic shock and/or the recruitment and activation of different leukocyte populations, causing acute inflammation of the CNS. Streptococcus suis can also evoke - through activation of microglial cells, astrocytes and possibly other cell types - a fulminant inflammatory reaction of the brain which leads to intracranial complications, including brain oedema, increased intracranial pressure, cerebrovascular insults, and deafness, as a result of cochlear sepsis. In all stages of the pathogenic process, S. suis interacts with many types of immunocompetent host's cells, such as polymorphonuclear leukocytes, mononuclear macrophages, lymphocytes, dendritic cells and microglia, using a range of versatile virulence factors for evasion of the innate and adaptive immune defence of the host, and for overcoming environmental stress. It is estimated that S. suis produces more than 100 different virulence

  13. Streptococcus suis: a re-emerging pathogen associated with occupational exposure to pigs or pork products. Part II – Pathogenesis

    Directory of Open Access Journals (Sweden)

    Jacek Dutkiewicz

    2018-03-01

    Full Text Available Streptococcus suis is a re-emerging zoonotic pathogen that may cause severe disease, mostly meningitis, in pigs and in humans having occupational contact with pigs and pork, such as farmers, slaughterhose workers and butchers. The first stage of the pathogenic process, similar in pigs and humans, is adherence to and colonisation of mucosal and/or epithelial surface(s of the host. The second stage is invasion into deeper tissue and extracellular translocation of bacterium in the bloodstream, either free in circulation or attached to the surface of monocytes. If S. suis present in blood fails to cause fatal septicaemia, it is able to progress into the third stage comprising penetration into host’s organs, mostly by crossing the blood-brain barrier and/or blood–cerebrospinal fluid barrier to gain access to the central nervous system (CNS and cause meningitis. The fourth stage is inflammation that plays a key role in the pathogen esis of both systemic and CNS infections caused by S. suis . The pathogen may induce the overproduction of pro-inflammatory cytokines that cause septic shock and/or the recruitment and activation of different leukocyte populations, causing acute inflammation of the CNS. Streptococcus suis can also evoke – through activation of microglial cells, astrocytes and possibly other cell types – a fulminant inflammatory reaction of the brain which leads to intracranial complications, including brain oedema, increased intracranial pressure, cerebrovascular insults, and deafness, as a result of cochlear sepsis. In all stages of the pathogenic process, S. suis interacts with many types of immunocompetent host’s cells, such as polymorphonuclear leukocytes, mononuclear macrophages, lymphocytes, dendritic cells and microglia, using a range of versatile virulence factors for evasion of the innate and adaptive immune defence of the host, and for overcoming environmental stress. It is estimated that S. suis produces more than

  14. In vitro transcription activities of Pol IV, Pol V and RDR2 reveal coupling of Pol IV and RDR2 for dsRNA synthesis in plant RNA silencing

    Energy Technology Data Exchange (ETDEWEB)

    Haag, Jeremy R.; Ream, Thomas S.; Marasco, Michelle; Nicora, Carrie D.; Norbeck, Angela D.; Pasa-Tolic, Ljiljana; Pikaard, Craig S.

    2012-12-14

    In Arabidopsis, RNA-dependent DNA methylation and transcriptional silencing involves three nuclear RNA polymerases that are biochemically undefined: the presumptive DNA-dependent RNA polymerases, Pol IV and Pol V and the putative RNA-dependent RNA polymerase, RDR2. Here, we demonstrate their RNA polymerase activities in vitro. Unlike Pol II, Pols IV and V require an RNA primer, are insensitive to alpha-amanitin and differ in their ability to displace non-template DNA during transcription. Biogenesis of 24 nt small interfering RNAs (siRNAs) requires both Pol IV and RDR2, which physically associate in vivo. Pol IV does not require RDR2 for activity, but RDR2 is nonfunctional in the absence of associated Pol IV, suggesting that their coupling explains the channeling of Pol IV transcripts into double-stranded RNAs that are then diced into 24 nt siRNAs.

  15. Los tres libros a Autólico de Teófilo de Antioquia y la Actitud Política de los cristianos en el siglo II

    Directory of Open Access Journals (Sweden)

    Daniel MORALES ESCOBAR

    2009-11-01

    Full Text Available El presente artículo tiene un objetivo muy concreto: llamar la atención sobre la importancia que Los tres libros a Autólico de Teófilo de Antioquia tienen como fuente histórica para d conocimiento de la actitud política de los cristianos en el último cuarto del siglo II, concretamente, en la época final del reinado de Marco Aurelio y de los primeros años del de Cómodo. Y ello porque hasta ahora nadie ha puesto de manifiesto esta importancia, cuando, por el contrario, se han dedicado muchas páginas al mismo tema en apologetas anteriores y posteriores a Teófilo, como son, entre los primeros, Justino, Melitón y Atenágoras, y entre los segundos, Apolonio y Tertuliano. Con ello no quiero decir que el nombre de Teófilo haya estado totalmente ausente de los trabajos publicados sobre las relaciones entre el cristianismo y el Imperio Romano, pero, desde luego, no ha sido objeto de la atención que en realidad merece.

  16. Occupational Licensing

    OpenAIRE

    Morris M. Kleiner

    2000-01-01

    The study of the regulation of occupations has a long and distinguished tradition in economics. In this paper, I present the central arguments and unresolved issues involving the costs and benefits of occupational licensing. The main benefits that are suggested for occupational licensing involve improving quality for those persons receiving the service. In contrast, the costs attributed to this labor market institution are that it restricts the supply of labor to the occupation and thereby dr...

  17. Occupational Dermatosis

    OpenAIRE

    Solak, Yavuzalp; Yoldaşcan, Elçin; Akbaba, Muhsin; Kurt, Burak

    2018-01-01

    Dermatosesthat occur as a result of primary irritation or sensitization are generallyreferred to as "occupational dermatosis", depending on work done by aperson, vehicle they are using and their workplace or work environment.Skin’s occupational diseases are most frequently reported occupational diseasesafter trauma. It constitutes ~ 50% of all occupational diseases. It isresponsible for ~ 25% of work loss. It is very important because it is bothfrequent and vulnerable. In addition, ...

  18. Dilemas da cooperação: conflitos gerados pela política das "Listas Negras" no Brasil durante a Segunda Guerra Mundial Dilemmas of cooperation: the conflicts provoked by the policy of "Black Lists" in Brazil during World War II

    Directory of Open Access Journals (Sweden)

    Tania Quintaneiro

    2006-12-01

    Full Text Available No artigo são analisados os conflitos políticos gerados pela implementação das "Listas Negras" norte-americanas entre órgãos estatais e interesses privados no Brasil durante a Segunda Guerra Mundial.The article analyses the political conflicts caused by the implementation of American Black Lists between State agencies and private interests in Brazil during World War II.

  19. Occupational mortality

    DEFF Research Database (Denmark)

    Lynge, Elsebeth

    2011-01-01

    INTRODUCTION: This paper aims to present the methods and main results from the Danish occupational mortality studies, and to set the Danish studies into the international context of occupational mortality studies. RESEARCH TOPICS: The first Danish occupational mortality study from 1970...

  20. An H3K9/S10 methyl-phospho switch modulates Polycomb and Pol II binding at repressed genes during differentiation.

    Science.gov (United States)

    Sabbattini, Pierangela; Sjoberg, Marcela; Nikic, Svetlana; Frangini, Alberto; Holmqvist, Per-Henrik; Kunowska, Natalia; Carroll, Tom; Brookes, Emily; Arthur, Simon J; Pombo, Ana; Dillon, Niall

    2014-03-01

    Methylated histones H3K9 and H3K27 are canonical epigenetic silencing modifications in metazoan organisms, but the relationship between the two modifications has not been well characterized. H3K9me3 coexists with H3K27me3 in pluripotent and differentiated cells. However, we find that the functioning of H3K9me3 is altered by H3S10 phosphorylation in differentiated postmitotic osteoblasts and cycling B cells. Deposition of H3K9me3/S10ph at silent genes is partially mediated by the mitogen- and stress-activated kinases (MSK1/2) and the Aurora B kinase. Acquisition of H3K9me3/S10ph during differentiation correlates with loss of paused S5 phosphorylated RNA polymerase II, which is present on Polycomb-regulated genes in embryonic stem cells. Reduction of the levels of H3K9me3/S10ph by kinase inhibition results in increased binding of RNAPIIS5ph and the H3K27 methyltransferase Ezh1 at silent promoters. Our results provide evidence of a novel developmentally regulated methyl-phospho switch that modulates Polycomb regulation in differentiated cells and stabilizes repressed states.

  1. O exercício profissional do assistente social no SUAS: atribuições privativas e projeto ético político (The occupational exercise from social workers at SUAS: private assignments and the ethnic-political project

    Directory of Open Access Journals (Sweden)

    Carina Berta Moljo

    2017-12-01

    Full Text Available Resumo:Este artigo sistematiza parte dos resultados de uma pesquisa cujo objetivo principal é conhecer e analisar o exercício profissional dos assistentes sociais inseridos nos Centros de Referência de Assistência Social de Juiz de Fora/MG. A metodologia utilizadafoi de análise bibliográfica e pesquisa de campo. Buscamos explicitar neste artigo as implicações causadas devido à tecnificação profissional e o modo como estas refletem no cotidiano dos assistentes sociais. Observamos uma forte precarização e flexibilização das condições do trabalho profissional, o que fragiliza a autonomia relativa do profissional. Do mesmo modo, a figura do “técnico SUAS” vem ganhando notoriedade; trazemos reflexões sobre uma “aparente indiferenciação” entre as profissões e o trabalho interdisciplinar. Finalmente, destacamos a importância do direcionamento ético e político no exercício profissional.  Palavras-chave: Exercício profissional. Centro de Referência de Assistência Social (CRAS. Projeto Ético Político. Abstract:This article systematizes part of the results of a research whose main objective was to know and analyze the occupational exercise of the social workers inserted on the Centro de Referência de Assistência Social (CRAS – Reference Center for Social Assistance in Juiz de Fora/MG. The mythology used were bibliographical analysis and field research. We seek to make explicit in this article the implications due to the professional technification and how this reflects on their daily basis. We observed a lack in flexibility of the work conditions, which fragilizes relative autonomy of the professional. In the same manner, the figure of the "SUAS technician" has gained notoriety, we bring reflections on an “apparent undifferentiation” between professions and interdisciplinary work. Finally, we highlight the importance of ethical and political direction in professional practice.Keywords: Occupational exercise

  2. Occupational Consciousness.

    Science.gov (United States)

    Ramugondo, Elelwani L

    2015-10-02

    Occupational consciousness refers to ongoing awareness of the dynamics of hegemony and recognition that dominant practices are sustained through what people do every day, with implications for personal and collective health. The emergence of the construct in post-apartheid South Africa signifies the country's ongoing struggle with negotiating long-standing dynamics of power that were laid down during colonialism, and maintained under black majority rule. Consciousness, a key component of the new terminology, is framed from post-colonial perspectives - notably work by Biko and Fanon - and grounded in the philosophy of liberation, in order to draw attention to continuing unequal intersubjective relations that play out through human occupation. The paper also draws important links between occupational consciousness and other related constructs, namely occupational possibilities, occupational choice, occupational apartheid, and collective occupation. The use of the term 'consciousness' in sociology, with related or different meanings, is also explored. Occupational consciousness is then advanced as a critical notion that frames everyday doing as a potentially liberating response to oppressive social structures. This paper advances theorizing as a scholarly practice in occupational science, and could potentially expand inter or transdisciplinary work for critical conceptualizations of human occupation.

  3. Occupational Consciousness

    Science.gov (United States)

    Ramugondo, Elelwani L.

    2015-01-01

    Occupational consciousness refers to ongoing awareness of the dynamics of hegemony and recognition that dominant practices are sustained through what people do every day, with implications for personal and collective health. The emergence of the construct in post-apartheid South Africa signifies the country’s ongoing struggle with negotiating long-standing dynamics of power that were laid down during colonialism, and maintained under black majority rule. Consciousness, a key component of the new terminology, is framed from post-colonial perspectives – notably work by Biko and Fanon – and grounded in the philosophy of liberation, in order to draw attention to continuing unequal intersubjective relations that play out through human occupation. The paper also draws important links between occupational consciousness and other related constructs, namely occupational possibilities, occupational choice, occupational apartheid, and collective occupation. The use of the term ‘consciousness’ in sociology, with related or different meanings, is also explored. Occupational consciousness is then advanced as a critical notion that frames everyday doing as a potentially liberating response to oppressive social structures. This paper advances theorizing as a scholarly practice in occupational science, and could potentially expand inter or transdisciplinary work for critical conceptualizations of human occupation. PMID:26549984

  4. Propuesta de Modelo Teórico que señala las variables de la Mercadotecnia política que influyen en el comportamiento electoral. Caso: Delegación D-II-IPN-7 del SNTE

    OpenAIRE

    Parra Ortega, Viridiana

    2013-01-01

    En Mexico cada vez mas se manejan estrategias de mercadotecnia política para lograr incentivar la desicion del voto, diversas variables que afectan el comportamiento electoral se encuentran inmersas dentro de la aplicación y estudio de la mercadotecnia política, pero no se han determinado las variables de mercadotecnia política que influyen en el comportamiento electoral.A partir de lo anterior el objetivo de esta investigación es: proponer un modelo teórico que señale las variables de mercad...

  5. Legalidad islámica y legitimidad política en el Califato de Córdoba: la proclamación de Hišām II

    Directory of Open Access Journals (Sweden)

    García Sanjuán, Alejandro

    2008-06-01

    Full Text Available This article deals with the process of proclamation as Caliph of Cordoba of Hišām, son and next-in-line to al-Ḥakam II, when he was scarcely eleven years old. Two problems are analyzed in relation to this aspect. On the one hand, from a legal point of view, it is brought into question the lawfulness of the government of an under age in the classical Islamic societies. On the other hand, the political crisis produced by the proclamation of Hišām as a consequence of the opposition to his proclamation in certain juridical and palatine circles. In this context, Ibn Abī ‘Āmir, the future Almanzor, managed to usurp the political authority, pushing aside the caliph and making in that way the caliphal institution fall into disrepute. As a result, the proclamation of Hišām constitutes the first stage of the crisis of the Cordoban caliphate, which finally led to its collapse.

    Este artículo aborda el proceso de proclamación como califa de Córdoba de Hišām, hijo y sucesor de al-Ḥakam II, cuando era todavía un niño de apenas once años. En relación con este aspecto, se analizan dos problemas. Desde el punto de vista jurídico, la cuestión de la legalidad del gobierno de un menor de edad en las sociedades islámicas clásicas. Por otro lado, la crisis política que la proclamación de Hišām desencadenó, debido a las resistencias que generaba en ciertos medios palatinos y jurídicos su minoría. En este contexto, Ibn Abī ‘Āmir, futuro Almanzor, logró usurpar el ejercicio del poder, marginando por completo al califa y provocando con ello el descrédito de la institución califal. Por todo ello, la proclamación de Hišām constituye la primera fase en la crisis del califato de Córdoba, que acabó desembocando en su abolición.

  6. Occupational Rhinitis.

    Science.gov (United States)

    Grammer, Leslie C

    2016-05-01

    Occupational rhinitis (OR) involves nasal congestion, rhinorrhea, nasal itching, and/or sneezing resulting from workplace exposures. OR can have a significant negative effect on quality of life and productivity. OR can be divided into allergic or nonallergic subgroups based on the underlying pathogenesis. Certain occupational exposures place employees at greater risk for developing disease. Primary treatment is avoidance of implicated exposures. Antihistamines, saline rinses, and nasal steroids may be useful. OR can coexist with occupational asthma, and rhinitis symptoms have been reported to precede those of the lower respiratory tract. OR is has both medical and socioeconomic implications. Copyright © 2016 Elsevier Inc. All rights reserved.

  7. GAGA factor maintains nucleosome-free regions and has a role in RNA polymerase II recruitment to promoters.

    Science.gov (United States)

    Fuda, Nicholas J; Guertin, Michael J; Sharma, Sumeet; Danko, Charles G; Martins, André L; Siepel, Adam; Lis, John T

    2015-03-01

    Previous studies have shown that GAGA Factor (GAF) is enriched on promoters with paused RNA Polymerase II (Pol II), but its genome-wide function and mechanism of action remain largely uncharacterized. We assayed the levels of transcriptionally-engaged polymerase using global run-on sequencing (GRO-seq) in control and GAF-RNAi Drosophila S2 cells and found promoter-proximal polymerase was significantly reduced on a large subset of paused promoters where GAF occupancy was reduced by knock down. These promoters show a dramatic increase in nucleosome occupancy upon GAF depletion. These results, in conjunction with previous studies showing that GAF directly interacts with nucleosome remodelers, strongly support a model where GAF directs nucleosome displacement at the promoter and thereby allows the entry Pol II to the promoter and pause sites. This action of GAF on nucleosomes is at least partially independent of paused Pol II because intergenic GAF binding sites with little or no Pol II also show GAF-dependent nucleosome displacement. In addition, the insulator factor BEAF, the BEAF-interacting protein Chriz, and the transcription factor M1BP are strikingly enriched on those GAF-associated genes where pausing is unaffected by knock down, suggesting insulators or the alternative promoter-associated factor M1BP protect a subset of GAF-bound paused genes from GAF knock-down effects. Thus, GAF binding at promoters can lead to the local displacement of nucleosomes, but this activity can be restricted or compensated for when insulator protein or M1BP complexes also reside at GAF bound promoters.

  8. GAGA factor maintains nucleosome-free regions and has a role in RNA polymerase II recruitment to promoters.

    Directory of Open Access Journals (Sweden)

    Nicholas J Fuda

    2015-03-01

    Full Text Available Previous studies have shown that GAGA Factor (GAF is enriched on promoters with paused RNA Polymerase II (Pol II, but its genome-wide function and mechanism of action remain largely uncharacterized. We assayed the levels of transcriptionally-engaged polymerase using global run-on sequencing (GRO-seq in control and GAF-RNAi Drosophila S2 cells and found promoter-proximal polymerase was significantly reduced on a large subset of paused promoters where GAF occupancy was reduced by knock down. These promoters show a dramatic increase in nucleosome occupancy upon GAF depletion. These results, in conjunction with previous studies showing that GAF directly interacts with nucleosome remodelers, strongly support a model where GAF directs nucleosome displacement at the promoter and thereby allows the entry Pol II to the promoter and pause sites. This action of GAF on nucleosomes is at least partially independent of paused Pol II because intergenic GAF binding sites with little or no Pol II also show GAF-dependent nucleosome displacement. In addition, the insulator factor BEAF, the BEAF-interacting protein Chriz, and the transcription factor M1BP are strikingly enriched on those GAF-associated genes where pausing is unaffected by knock down, suggesting insulators or the alternative promoter-associated factor M1BP protect a subset of GAF-bound paused genes from GAF knock-down effects. Thus, GAF binding at promoters can lead to the local displacement of nucleosomes, but this activity can be restricted or compensated for when insulator protein or M1BP complexes also reside at GAF bound promoters.

  9. Occupational Asthma

    Science.gov (United States)

    ... the enzymes of the bacteria Bacillus subtilis, while bakers may develop an allergy and occupational asthma symptoms ... counts Continuing education center Find an allergist / immunologist Journals Login / My membership Search your symptoms Shop the ...

  10. Occupational Health

    Science.gov (United States)

    Occupational health problems occur at work or because of the kind of work you do. These problems can include ... by exposure to radiation Exposure to germs in health care settings Good job safety and prevention practices ...

  11. Occupational health

    CERN Document Server

    Fingret, Dr Ann

    2013-01-01

    Offers a comprehensive view of health and safety issues at work. An invaluable resource for managers, personnel professionals and occupational health practitioners. Recommended by the Institute of Personnel Management.

  12. [MATCHE: Management Approach to Teaching Consumer and Homemaking Education.] Occupational Strand: Textiles and Clothing. Module II-D-3: Merchandising Textiles and Ready-to-Wear.

    Science.gov (United States)

    Gylling, Margaret

    This competency-based preservice home economics teacher education module on merchandising textiles and ready-to-wear is the third in a set of three modules on occupational aspects of textiles and clothing. (This set is part of a larger series of sixty-seven modules on the Management Approach to Teaching Consumer and Homemaking Education…

  13. [Assurance and assessment of education quality in occupational medicine of selected countries of Western Europe and the United States. II. USA].

    Science.gov (United States)

    Boczkowski, A

    2000-01-01

    The author discusses the studies undertaken with the general aim to provide education in occupational medicine and assure its quality assessment in some countries of Western Europe advanced more than Poland in this area. It becomes quite evident that despite a widespread interest in quality of education, there is a lack of basic systemic solutions, and a gap between basic theoretical and methodological guidelines and a large number of dispersed reports on concrete analytical and evaluation studies can be still observed. In addition to the presentation of an inside view of research activities carried out in some countries of Western Europe and the United States, based on selected professional publications, the author formulates general conclusions on how the assurance and quality assessment of education in occupational medicine function in those countries.

  14. Relationships of RNA polymerase II genetic interactors to transcription start site usage defects and growth in Saccharomyces cerevisiae.

    Science.gov (United States)

    Jin, Huiyan; Kaplan, Craig D

    2014-11-06

    Transcription initiation by RNA Polymerase II (Pol II) is an essential step in gene expression and regulation in all organisms. Initiation requires a great number of factors, and defects in this process can be apparent in the form of altered transcription start site (TSS) selection in Saccharomyces cerevisiae (Baker's yeast). It has been shown previously that TSS selection in S. cerevisiae is altered in Pol II catalytic mutants defective in a conserved active site feature known as the trigger loop. Pol II trigger loop mutants show growth phenotypes in vivo that correlate with biochemical defects in vitro and exhibit wide-ranging genetic interactions. We assessed how Pol II mutant growth phenotypes and TSS selection in vivo are modified by Pol II genetic interactors to estimate the relationship between altered TSS selection in vivo and organismal fitness of Pol II mutants. We examined whether the magnitude of TSS selection defects could be correlated with Pol II mutant-transcription factor double mutant phenotypes. We observed broad genetic interactions among Pol II trigger loop mutants and General Transcription Factor (GTF) alleles, with reduced-activity Pol II mutants especially sensitive to defects in TFIIB. However, Pol II mutant growth defects could be uncoupled from TSS selection defects in some Pol II allele-GTF allele double mutants, whereas a number of other Pol II genetic interactors did not influence ADH1 start site selection alone or in combination with Pol II mutants. Initiation defects are likely only partially responsible for Pol II allele growth phenotypes, with some Pol II genetic interactors able to exacerbate Pol II mutant growth defects while leaving initiation at a model TSS selection promoter unaffected. Copyright © 2015 Jin and Kaplan.

  15. As políticas activas e passivas do mercado de trabalho

    OpenAIRE

    Novo, Álvaro; Centeno, Mário

    2008-01-01

    A generalidade dos países utiliza políticas destinadas a minorar os custos sociais e individuais do desemprego. Os economistas classificam estas políticas do mercado de trabalho em dois grupos: (i) políticas activas e (ii) políticas passivas. As primeiras têm como objectivo dotar os desempregados com as qualificações necessárias para minimizar a duração do desemprego, enquanto as segundas visam garantir uma fonte de rendimento durante o período de desemprego, sendo particularmente úteis para ...

  16. Relationships (II) of International Classification of High-resolution Computed Tomography for Occupational and Environmental Respiratory Diseases with ventilatory functions indices for parenchymal abnormalities.

    Science.gov (United States)

    Tamura, Taro; Suganuma, Narufumi; Hering, Kurt G; Vehmas, Tapio; Itoh, Harumi; Akira, Masanori; Takashima, Yoshihiro; Hirano, Harukazu; Kusaka, Yukinori

    2015-01-01

    The International Classification of High-Resolution Computed Tomography (HRCT) for Occupational and Environmental Respiratory Diseases (ICOERD) is used to screen and diagnose respiratory illnesses. Using univariate and multivariate analysis, we investigated the relationship between subject characteristics and parenchymal abnormalities according to ICOERD, and the results of ventilatory function tests (VFT). Thirty-five patients with and 27 controls without mineral-dust exposure underwent VFT and HRCT. We recorded all subjects' occupational history for mineral dust exposure and smoking history. Experts independently assessed HRCT using the ICOERD parenchymal abnormalities (Items) grades for well-defined rounded opacities (RO), linear and/or irregular opacities (IR), and emphysema (EM). High-resolution computed tomography showed that 11 patients had RO; 15 patients, IR; and 19 patients, EM. According to the multiple regression model, age and height had significant associations with many indices ventilatory functions such as vital capacity, forced vital capacity, and forced expiratory volume in 1 s (FEV1). The EM summed grades on the upper, middle, and lower zones of the right and left lungs also had significant associations with FEV1 and the maximum mid-expiratory flow rate. The results suggest the ICOERD notation is adequate based on the good and significant multiple regression modeling of ventilatory function with the EM summed grades.

  17. Occupational rhinitis affects occupational asthma severity.

    Science.gov (United States)

    Moscato, Gianna; Pala, Gianni; Folletti, Ilenia; Siracusa, Andrea; Quirce, Santiago

    2016-06-16

    The strong interactions between asthma and rhinitis, and the influence of rhinitis in the severity and/or control of asthma, have clearly been demonstrated. Nevertheless, no specific study has been conducted in the occupational setting. The aim of the study was to assess the severity of occupational asthma and rhinitis and evaluate whether rhinitis is a predictor for increased asthma severity. We retrospectively reviewed the clinical charts of 72 patients who received a diagnosis of allergic occupational asthma, with or without associated occupational rhinitis. Our findings suggested that persistent asthma tended to be more common in subjects with associated occupational asthma and rhinitis, and occupational asthma severity was associated with occupational rhinitis severity. Moderate-severe persistent occupational rhinitis is a risk factor for persistent occupational asthma. We demonstrated, for the first time in the occupational setting, a significant association between occupational rhinitis and asthma severity.

  18. Política y Administración Provincial. La Diputación de Sevilla durante la Dictadura de Primo de Rivera y la II República (1923-1936).

    OpenAIRE

    Ponce Alberca, Julio

    2016-01-01

    Desde la perspectiva de fines del siglo XX, los regímenes políticos de la España de los años veinte y treinta aparecen como una secuencia de ensayos en respuesta a la profunda crisis sufrida por el sistema de la Restauración (1876-1923). Bajo ese enfoque, la Segunda República (1931-1936) se nos muestra inscrita en el esfuerzo por encontrar una nueva alternativa tras el fracaso de la Dictadura primorriverista (1923-1930) y las dictablandas del genera...

  19. Back to the future: sweatshop conditions on the Mexico-U.S. border. II. Occupational health impact of maquiladora industrial activity.

    Science.gov (United States)

    Moure-Eraso, R; Wilcox, M; Punnett, L; MacDonald, L; Levenstein, C

    1997-05-01

    Present working conditions in one of the most active areas of the maquiladora system along the Mexico-U.S. border are reminiscent of nineteenth-century U.S. sweatshops. The organization of production is Tayloristic and authoritarian, with detailed division of labor, repetitive simple tasks, and piecework wages. Modern participative management styles are not apparent in the maquiladora setting. This study consists of two separate but interrelated surveys conducted in 1992, one of community leaders and this one of workers in maquiladora enterprises in the towns of Matamoros and Reynosa, Mexico. The community survey evaluated the economic and psychosocial impact of the maquiladora enterprise and was conducted simultaneously to the workers' survey and in the same Mexican towns where the workers lived and worked. The community leaders acknowledged the employment opportunities that maquiladora factories had brought to the region but believed them to have high environmental and psychosocial costs. For the occupational component, a community-based survey of 267 maquiladora workers was conducted. participants were chosen with more than a year seniority in the industry and living in the two Mexican cities surveyed. They responded to an extensive questionnaire given by trained canvassers. The workers' survey found evidence that maquiladora workers (81% female) report symptoms from musculoskeletal disorders related to working conditions. Acute health effects compatible with chemical exposures were also identified. Prevalence of symptoms was correlated with increasing duration of exposure to ergonomic risk factors and qualitative chemical exposure indexes. Other chronic disease was not apparent. The survey demonstrated inequalities in salary, working hours, and safety training between the two communities. Matamoros workers are substantially better paid and work fewer hours per week than Reynosa workers. Most hazards reported in the worker's survey have been well studied in the

  20. Occupation: nurse; occupational hazard: radiation

    International Nuclear Information System (INIS)

    Nickson, K.

    1984-01-01

    The work of the occupational health nurses at the Pickering Generating Station is described. A staff of two nurses teach first aid and safety, practice an emergency plan, and monitor personnel for minimum health standards for radiation workers. Special attention is paid to problems which might be aggravated by radiation, such as skin complaints, respiratory diseases, emotional stability, or phobias regarding heights, plastic suits, or radiation itself. Procedures used in treating contaminated personnel are outlined

  1. Occupation: nurse; occupational hazard: radiation

    Energy Technology Data Exchange (ETDEWEB)

    Nickson, K.

    1984-03-01

    The work of the occupational health nurses at the Pickering Generating Station is described. A staff of two nurses teach first aid and safety, practice an emergency plan, and monitor personnel for minimum health standards for radiation workers. Special attention is paid to problems which might be aggravated by radiation, such as skin complaints, respiratory diseases, emotional stability, or phobias regarding heights, plastic suits, or radiation itself. Procedures used in treating contaminated personnel are outlined.

  2. Occupational physiology

    CERN Document Server

    Toomingas, Allan; Tornqvist, Ewa Wigaeus

    2011-01-01

    In a clear and accessible presentation, Occupational Physiology focuses on important issues in the modern working world. Exploring major public health problems-such as musculoskeletal disorders and stress-this book explains connections between work, well-being, and health based on up-to-date research in the field. It provides useful methods for risk assessment and guidelines on arranging a good working life from the perspective of the working individual, the company, and society as a whole.The book focuses on common, stressful situations in different professions. Reviewing bodily demands and r

  3. Bases teórico-políticas del bloque ibérico : la relación peninsular en la fase de inflexión de la II Guerra Mundial, 1942-1945

    Directory of Open Access Journals (Sweden)

    Juan Carlos Jiménez Redondo

    1994-01-01

    Full Text Available Al abordar las relaciones entre España y Portugal cualquiera que sea el momento histórico escogido, resulta siempre sorprendente comprobar cómo una frontera política, ausente de impedimentos naturales, ha podido levantar un muro difícilmente franqueable entre ambas comunidades. De hecho, la noción de vecindad tiene en el caso hispano-portugués una dimensión estática, basada en el hecho de una contigüedad geográfica, que contrasta con la dimensión dinámica propia de una relación de vecindad, donde los actores no sólo están unidos geográficamente sino que se da una comunicación y relación efectiva entre ellos.

  4. Modeling Disease Vector Occurrence When Detection Is Imperfect II: Drivers of Site-Occupancy by Synanthropic Triatoma brasiliensis in the Brazilian Northeast

    Science.gov (United States)

    Valença-Barbosa, Carolina; Lima, Marli M.; Sarquis, Otília; Bezerra, Claudia M.; Abad-Franch, Fernando

    2014-01-01

    Background Understanding the drivers of habitat selection by insect disease vectors is instrumental to the design and operation of rational control-surveillance systems. One pervasive yet often overlooked drawback of vector studies is that detection failures result in some sites being misclassified as uninfested; naïve infestation indices are therefore biased, and this can confound our view of vector habitat preferences. Here, we present an initial attempt at applying methods that explicitly account for imperfect detection to investigate the ecology of Chagas disease vectors in man-made environments. Methodology We combined triplicate-sampling of individual ecotopes (n = 203) and site-occupancy models (SOMs) to test a suite of pre-specified hypotheses about habitat selection by Triatoma brasiliensis. SOM results were compared with those of standard generalized linear models (GLMs) that assume perfect detection even with single bug-searches. Principal Findings Triatoma brasiliensis was strongly associated with key hosts (native rodents, goats/sheep and, to a lesser extent, fowl) in peridomestic environments; ecotope structure had, in comparison, small to negligible effects, although wooden ecotopes were slightly preferred. We found evidence of dwelling-level aggregation of infestation foci; when there was one such focus, same-dwelling ecotopes, whether houses or peridomestic structures, were more likely to become infested too. GLMs yielded negatively-biased covariate effect estimates and standard errors; both were, on average, about four times smaller than those derived from SOMs. Conclusions/Significance Our results confirm substantial population-level ecological heterogeneity in T. brasiliensis. They also suggest that, at least in some sites, control of this species may benefit from peridomestic rodent control and changes in goat/sheep husbandry practices. Finally, our comparative analyses highlight the importance of accounting for the various sources of

  5. Modeling disease vector occurrence when detection is imperfect II: Drivers of site-occupancy by synanthropic Triatoma brasiliensis in the Brazilian northeast.

    Directory of Open Access Journals (Sweden)

    Carolina Valença-Barbosa

    2014-05-01

    Full Text Available BACKGROUND: Understanding the drivers of habitat selection by insect disease vectors is instrumental to the design and operation of rational control-surveillance systems. One pervasive yet often overlooked drawback of vector studies is that detection failures result in some sites being misclassified as uninfested; naïve infestation indices are therefore biased, and this can confound our view of vector habitat preferences. Here, we present an initial attempt at applying methods that explicitly account for imperfect detection to investigate the ecology of Chagas disease vectors in man-made environments. METHODOLOGY: We combined triplicate-sampling of individual ecotopes (n = 203 and site-occupancy models (SOMs to test a suite of pre-specified hypotheses about habitat selection by Triatoma brasiliensis. SOM results were compared with those of standard generalized linear models (GLMs that assume perfect detection even with single bug-searches. PRINCIPAL FINDINGS: Triatoma brasiliensis was strongly associated with key hosts (native rodents, goats/sheep and, to a lesser extent, fowl in peridomestic environments; ecotope structure had, in comparison, small to negligible effects, although wooden ecotopes were slightly preferred. We found evidence of dwelling-level aggregation of infestation foci; when there was one such focus, same-dwelling ecotopes, whether houses or peridomestic structures, were more likely to become infested too. GLMs yielded negatively-biased covariate effect estimates and standard errors; both were, on average, about four times smaller than those derived from SOMs. CONCLUSIONS/SIGNIFICANCE: Our results confirm substantial population-level ecological heterogeneity in T. brasiliensis. They also suggest that, at least in some sites, control of this species may benefit from peridomestic rodent control and changes in goat/sheep husbandry practices. Finally, our comparative analyses highlight the importance of accounting for the

  6. Image processing occupancy sensor

    Science.gov (United States)

    Brackney, Larry J.

    2016-09-27

    A system and method of detecting occupants in a building automation system environment using image based occupancy detection and position determinations. In one example, the system includes an image processing occupancy sensor that detects the number and position of occupants within a space that has controllable building elements such as lighting and ventilation diffusers. Based on the position and location of the occupants, the system can finely control the elements to optimize conditions for the occupants, optimize energy usage, among other advantages.

  7. Occupational therapy students' perceptions of occupational therapy.

    Science.gov (United States)

    Turpin, Merrill June; Rodger, Sylvia; Hall, Anna R

    2012-10-01

    An understanding of students' perceptions of occupational therapy on entry is required to recognise how professional socialisation occurs through curriculum. Findings pertain to a qualitative study investigating students' perceptions of occupational therapy upon entry to two occupational therapy programmes in Australia. Students commencing Bachelor of Occupational Therapy and Masters of Occupational Therapy Studies programmes participated in the study (n = 462). A purpose-designed questionnaire was distributed to students in the first lecture of each programme. Preliminary analysis comprised identification of keywords/phrases and coding categories were generated from patterns of keywords. Frequency counts and percentages of keywords/phrases within categories were completed. Students' responses were categorised as 'what' occupational therapists do; 'how' they do it; 'why' they do it; and 'who' they work with. In 'what' occupational therapists do students frequently described 'helping' people. Both undergraduate and graduate entry masters students used the term 'rehabilitation' to describe how occupational therapy is done, with graduate entry students occasionally responding with 'through occupation' and 'modifying the environment'. Students perceived the 'why' of occupational therapy as getting back to 'everyday activities', with some students emphasising returning to 'normal' activities or life. Regarding the 'who' category, students also thought occupational therapists worked with people with an 'injury' or 'disability'. Students entered their occupational therapy programmes with perceptions consistent with the general public's views of occupational therapy. However, graduate entry students exposed to a pre-reading package prior to entry had more advanced occupational therapy concepts than undergraduate students. © 2011 The Authors. Australian Occupational Therapy Journal © 2011 Occupational Therapy Australia.

  8. The MMT-POL Instrument Control System

    Science.gov (United States)

    Warner, C.; Packham, C.; Jones, T. J.; Varosi, F.; Eikenberry, S. S.; Dewahl, K.; Krejny, M.

    2011-07-01

    Instrument control system (ICS) suites are a continually evolving class of software packages that are highly dependent upon the design choices and application programming interfaces (APIs) of the observatory control system (OCS), as well as the hardware choices for motors and electronics. We present the ICS for MMT-POL, a 1-5 μm polarimeter for the MMT telescope, in the context of being a transitional step between the software packages developed for facility class instruments at the University of Florida (UF), such as Flamingos-II and CanariCam, and in preparation for 30 m-class instruments. Our goals for improving ICS suites are to make them (a) portable (compile once, run anywhere), (b) highly modular and extensible (through the re-use of common libraries), (c) multi-threaded (to allow multiple tasks to be performed in parallel), (d) smart, and (e) easy to use and maintain. An ICS should also be well-defined and use mature languages (we choose Java and Python) and common standards (such as XML and the FITS file format). We also note that as hardware moves away from serial communications to ethernet, the use of TCP sockets makes communication faster and easier. Below, we present our design choices for the MMT-POL ICS and discuss our reasons for these choices and potential issues that must be addressed for future ICS suites ready for thirty meter class instruments.

  9. The influence of occupational licensing and regulation

    OpenAIRE

    Kleiner, Morris M.

    2017-01-01

    Since the end of World War II, occupational licensing has been one of the fastest growing labor market institutions in the developed world. The economics literature suggests that licensing can influence wage determination, the speed at which workers find employment, pension and health benefits, and prices. Moreover, there is little evidence to show that licensing improves service quality, health, or safety in developed nations. So, why is occupational licensing is growing when there are such ...

  10. Recrutamento político

    OpenAIRE

    Norris, Pippa

    2013-01-01

    O objetivo principal deste artigo é apresentar uma breve revisão da literatura sobre recrutamento político e oferecer alguns critérios empíricos para análise. A partir de uma perspectiva integrada, nos estabelecemos um modelo de análise que trabalha com a estrutural social e as instituições políticas. O modelo de oferta e demanda foi mobilizado para relacionar os inputs do background social e as possíveis consequências nas instituições. Os dados apresentados provém de uma diversidade de fonte...

  11. A implantação da "Política de Saúde Ocupacional para Servidores Públicos": histórias construídas na UFRJ La implantacin de la "Política de Salúd Ocupacional para los Servidores Públicos": histórias construidas en la UFRJ The implantation of "Politic of health Occupational from the Publics Servants": histories constructed in UFRJ

    Directory of Open Access Journals (Sweden)

    Washington Ramos Castro

    2006-12-01

    Full Text Available O presente estudo apresenta aspectos relevantes relacionados às construções da saúde do trabalhador na Universidade Federal do Rio de Janeiro (UFRJ, em toda a sua existência. Abordagem especial foi dada aos aspectos da construção que levaram a Divisão de Saúde do Trabalhador da UFRJ a ser uma das entidades parceiras na implementação das "Normas Regulamentadoras de Seguridade Social e de Saúde dos Servidores Públicos Federais Civis no Rio de Janeiro". Trata-se de um levantamento histórico bibliográfico, baseado em fontes primárias e secundárias, que abordou um período de 85 anos da história desta Universidade, em que, inicialmente, não havia um serviço de atendimento à saúde do trabalhador, e também os aspectos políticos de sua criação e desenvolvimento, assim como os desdobramentos práticos e efetivos, decorrentes dos avanços e retrocessos ocorridos no desenvolvimento histórico da atenção à saúde do trabalhador nesta Universidade.El presente estudio presenta aspectos relevantes relacionados a las construcciones de la salud del trabajador en la Universidad Federal de Rio de Janeiro (UFRJ, en toda su existencia, ha sido dado abordaje especial a los aspectos de la construcción que llevaron la División de Salud del Trabajador (DVST de UFRJ a convertirse en una de las entidades colaboradoras en la implantación de las "Normas Reglamentarias de la Seguridad Social y de Salud de los Servidores Públicos Federales Civiles en Rio de Janeiro, Brasil". Se trata de un una pesquisa histórico-bibliográfica, basada en documentos fuentes primarias y secundarias, que han señalado un período de 85 anõs de la historia de esta Universidad en el que no había un servicio de atención a la salud del trabajador, tal como los aspectos políticos de su creación y desarrollo, tal como los desdoblamientos prácticos y efectivos, resultantes de los avances y retrocesos ocurridos en el proceso de desarrollo histórico de atención a

  12. Desde la proclamación de la República al 18 de julio de 1936 : el cambio de rumbo político en la II División Orgánica

    OpenAIRE

    Gil Honduvilla, Joaquín

    2009-01-01

    Análisis del proceso de cambio de mentalidad de los militares en el período 1931-1936 y de las circunstancias que determinaron que unos oficiales que en 1931 aceptaron sin resistencia el nuevo régimen, cinco años después procedieran a derrocarlo, todo ello en el ámbito espacial de la región andaluza (II División Orgánica).----------------------------Analysis of the process of change of mentality of the military men in the period 1931-1936 and of the circunstances that determinate that a few o...

  13. Recrutamento político

    Directory of Open Access Journals (Sweden)

    Pippa Norris

    2013-06-01

    Full Text Available O objetivo principal deste artigo é apresentar uma breve revisão da literatura sobre recrutamento político e oferecer alguns critérios empíricos para análise. A partir de uma perspectiva integrada, nos estabelecemos um modelo de análise que trabalha com a estrutural social e as instituições políticas. O modelo de oferta e demanda foi mobilizado para relacionar os inputs do background social e as possíveis consequências nas instituições. Os dados apresentados provém de uma diversidade de fontes e privilegiaram os processos de inclusão de mulheres em diferentes tipos de democracias e sociedades. Os resultados mostram que somente através da interação da estrutural social com as demandas institucionais é possível conhecer o resultado final da representatividade e os filtros do recrutamento político. Além disso, os dados nos permitiram desvendar um incremento da participação das bases sociais do partido no processo de nominação de candidatos. Concluímos que o processo de seleção de candidatos é uma das mais técnicas e privadas funções dos partidos políticos. O aumento da oferta e o estreitamento da demanda tem promovido uma série de consequências para a democracia representativa, como a inserção de mulheres ao mesmo tempo em que se profissionalizam os partidos políticos..

  14. Getting up to speed with transcription elongation by RNA polymerase II

    NARCIS (Netherlands)

    Jonkers, Iris; Lis, John T.

    Recent advances in sequencing techniques that measure nascent transcripts and that reveal the positioning of RNA polymerase II (Pol II) have shown that the pausing of Pol II in promoter-proximal regions and its release to initiate a phase of productive elongation are key steps in transcription

  15. Structural basis of RNA polymerase II backtracking, arrest and reactivation.

    Science.gov (United States)

    Cheung, Alan C M; Cramer, Patrick

    2011-03-10

    During gene transcription, RNA polymerase (Pol) II moves forwards along DNA and synthesizes messenger RNA. However, at certain DNA sequences, Pol II moves backwards, and such backtracking can arrest transcription. Arrested Pol II is reactivated by transcription factor IIS (TFIIS), which induces RNA cleavage that is required for cell viability. Pol II arrest and reactivation are involved in transcription through nucleosomes and in promoter-proximal gene regulation. Here we present X-ray structures at 3.3 Å resolution of an arrested Saccharomyces cerevisiae Pol II complex with DNA and RNA, and of a reactivation intermediate that additionally contains TFIIS. In the arrested complex, eight nucleotides of backtracked RNA bind a conserved 'backtrack site' in the Pol II pore and funnel, trapping the active centre trigger loop and inhibiting mRNA elongation. In the reactivation intermediate, TFIIS locks the trigger loop away from backtracked RNA, displaces RNA from the backtrack site, and complements the polymerase active site with a basic and two acidic residues that may catalyse proton transfers during RNA cleavage. The active site is demarcated from the backtrack site by a 'gating tyrosine' residue that probably delimits backtracking. These results establish the structural basis of Pol II backtracking, arrest and reactivation, and provide a framework for analysing gene regulation during transcription elongation.

  16. Occupational hearing loss

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/article/001048.htm Occupational hearing loss To use the sharing features on this page, please enable JavaScript. Occupational hearing loss is damage to the inner ear from noise ...

  17. Occupational Noise Exposure

    Science.gov (United States)

    ... Safety and Health Topics / Occupational Noise Exposure Occupational Noise Exposure This page requires that javascript be enabled ... interprets the signal as sound. x What is noise? Noise and vibration are both fluctuations in the ...

  18. Detection of Pol IV/RDR2-dependent transcripts at the genomic scale in Arabidopsis reveals features and regulation of siRNA biogenesis

    Science.gov (United States)

    Li, Shaofang; Vandivier, Lee E.; Tu, Bin; Gao, Lei; Won, So Youn; Li, Shengben; Zheng, Binglian; Gregory, Brian D.

    2015-01-01

    Twenty-four-nucleotide small interfering (si)RNAs are central players in RNA-directed DNA methylation (RdDM), a process that establishes and maintains DNA methylation at transposable elements to ensure genome stability in plants. The plant-specific RNA polymerase IV (Pol IV) is required for siRNA biogenesis and is believed to transcribe RdDM loci to produce primary transcripts that are converted to double-stranded RNAs (dsRNAs) by RDR2 to serve as siRNA precursors. Yet, no such siRNA precursor transcripts have ever been reported. Here, through genome-wide profiling of RNAs in genotypes that compromise the processing of siRNA precursors, we were able to identify Pol IV/RDR2-dependent transcripts from tens of thousands of loci. We show that Pol IV/RDR2-dependent transcripts correspond to both DNA strands, whereas the RNA polymerase II (Pol II)-dependent transcripts produced upon derepression of the loci are derived primarily from one strand. We also show that Pol IV/RDR2-dependent transcripts have a 5′ monophosphate, lack a poly(A) tail at the 3′ end, and contain no introns; these features distinguish them from Pol II-dependent transcripts. Like Pol II-transcribed genic regions, Pol IV-transcribed regions are flanked by A/T-rich sequences depleted in nucleosomes, which highlights similarities in Pol II- and Pol IV-mediated transcription. Computational analysis of siRNA abundance from various mutants reveals differences in the regulation of siRNA biogenesis at two types of loci that undergo CHH methylation via two different DNA methyltransferases. These findings begin to reveal features of Pol IV/RDR2-mediated transcription at the heart of genome stability in plants. PMID:25414514

  19. Occupational Therapy (For Parents)

    Science.gov (United States)

    ... Staying Safe Videos for Educators Search English Español Occupational Therapy KidsHealth / For Parents / Occupational Therapy What's in this ... care for some kids. Kids Who Might Need Occupational Therapy According to the AOTA, kids with these medical ...

  20. New and Emerging Occupations: Fact or Fancy.

    Science.gov (United States)

    Bienstock, Herbert

    The job market should be considered as interaction between supply and demand, and not from the perspective of new and emerging occupations. Three recent major post-World War II changes in the human resources posture have tended to create labor surpluses: shift from rural South to urban North, increased number of working women, and the postwar baby…

  1. Occupational rhinitis: an update.

    Science.gov (United States)

    Stevens, Whitney W; Grammer, Leslie C

    2015-01-01

    Occupational rhinitis is characterized by nasal congestion, rhinorrhea, nasal itching, and/or sneezing that occur secondary to exposures in the workplace. This disease can be classified into allergic or nonallergic subgroups based upon the underlying disease pathogenesis as well as the type of causative agent. While the true prevalence of occupational rhinitis is unknown, there are certain professions and occupational exposures that place workers at a higher risk for developing the disease. Additionally, occupational rhinitis can be associated with occupational asthma and upper airway symptoms may precede those of the lower respiratory tract. Taken together, occupational rhinitis is an important disease for study given its medical as well as socioeconomic implications. This review will focus on the classification of occupational rhinitis as well the prevalence, diagnosis, and treatment strategies.

  2. Serie Umbral Político - Num 2.

    OpenAIRE

    Equipo Programa de Estudios de Opinión

    2005-01-01

    Este segundo número de Umbral Político sigue la senda de esa pregunta, que planteamos en el primer número: "- ¿A dónde vas Costa Rica?" Pues con él lo que buscamos es establecer un diálogo que dilucide problemas, propicie refl exiones y genere propuestas, en ese proceso colectivo y nacional de construcción de país que se nos impone como imperativo cívico. En éste número: I. Democracia, incertidumbre y abstencionismo Democracia e incertidumbre Incertidumbre y abstencionismoII. Un esfuerz...

  3. Inference for occupancy and occupancy dynamics

    Science.gov (United States)

    O'Connell, Allan F.; Bailey, Larissa L.; O'Connell, Allan F.; Nichols, James D.; Karanth, K. Ullas

    2011-01-01

    This chapter deals with the estimation of occupancy as a state variable to assess the status of, and track changes in, species distributions when sampling with camera traps. Much of the recent interest in occupancy estimation and modeling originated from the models developed by MacKenzie et al. (2002, 2003), although similar methods were developed independently (Azuma et al. 1990; Bayley and Petersen 2001; Nichols and Karanth, 2002; Tyre et al. 2003), all of which deal with species occurrence information and imperfect detection. Less than a decade after these publications, the modeling and estimation of species occurrence and occupancy dynamics have increased significantly. Special features of scientific journals have explored innovative uses of detection–nondetection data with occupancy models (Vojta 2005), and an entire volume has synthesized the use and application of occupancy estimation methods (MacKenzie et al. 2006). Reviews of the topical concepts, philosophical considerations, and various sampling designs that can be used for occupancy estimation are now readily available for a range of audiences (MacKenzie and Royle 2005; MacKenzie et al. 2006; Bailey et al. 2007; Royle and Dorazio 2008; Conroy and Carroll 2009; Kendall and White 2009; Hines et al. 2010; Link and Barker 2010). As a result, it would be pointless here to recast all that these publications have so eloquently articulated, but that said, a review of any scientific topic requires sufficient context and relevant background information, especially when relatively new methodologies and techniques such as occupancy estimation and camera traps are involved. This is especially critical in a digital age where new information is published at warp speed, making it increasingly difficult to stay abreast of theoretical advances and research developments.

  4. Sangres políticas

    Directory of Open Access Journals (Sweden)

    Gabriel Gatti

    2018-03-01

    Full Text Available Trabajamos en las tensiones entre dos continentes en permanente disputa: “sangre” y “política”, “realidad” y “dispositivo”, “naturaleza” y “cultura”. Son viejos asuntos, y viejas tensiones, pero que no dejan de actualizarse y que ahora se manifiestan por doquier en cuestiones como la biometría, los mapas genéticos, la identificación de desaparecidos, las políticas de la identidad indígena o de género o de menores o de drogas, la gestación subrogada o la gestión de la marginalidad. Los diez textos recogidos en este número especial discuten desde una mirada interdisciplinaria sobre la presencia de la sangre —en sus distintas declinaciones— en la definición contemporánea de lo que entendemos por identidad, derechos humanos o ciudadanía.

  5. Mechanisms of backtrack recovery by RNA polymerases I and II.

    Science.gov (United States)

    Lisica, Ana; Engel, Christoph; Jahnel, Marcus; Roldán, Édgar; Galburt, Eric A; Cramer, Patrick; Grill, Stephan W

    2016-03-15

    During DNA transcription, RNA polymerases often adopt inactive backtracked states. Recovery from backtracks can occur by 1D diffusion or cleavage of backtracked RNA, but how polymerases make this choice is unknown. Here, we use single-molecule optical tweezers experiments and stochastic theory to show that the choice of a backtrack recovery mechanism is determined by a kinetic competition between 1D diffusion and RNA cleavage. Notably, RNA polymerase I (Pol I) and Pol II recover from shallow backtracks by 1D diffusion, use RNA cleavage to recover from intermediary depths, and are unable to recover from extensive backtracks. Furthermore, Pol I and Pol II use distinct mechanisms to avoid nonrecoverable backtracking. Pol I is protected by its subunit A12.2, which decreases the rate of 1D diffusion and enables transcript cleavage up to 20 nt. In contrast, Pol II is fully protected through association with the cleavage stimulatory factor TFIIS, which enables rapid recovery from any depth by RNA cleavage. Taken together, we identify distinct backtrack recovery strategies of Pol I and Pol II, shedding light on the evolution of cellular functions of these key enzymes.

  6. Política, marketing e neoliberalismo

    Directory of Open Access Journals (Sweden)

    Pedro Roberto Ferreira

    2004-07-01

    Full Text Available O texto contém uma análise da relação política e sua possível consciência no seu momento específico compreendido pelo processo eleitoral (Londrina - eleições 92. Como este processo eleitoral em nossos dias, nutre-se de algumas técnicas conhecidas como Marketing Político-Eleitoral, e de como estas, contribuem para uma dinâmica de esvaziamento da vida política propriamente dita. Procura ainda, conectar esse esvaziamento político e suas consequências, com o avanço da concepção neoliberal cujo ápice parece fazer coincidir a política como mais uma manifestação de Mercado.

  7. A política do ensaio político de catálogo

    Directory of Open Access Journals (Sweden)

    Julian Stallabrass

    2010-01-01

    Full Text Available Este texto foi originalmente publicado no livro Villa Lituania, que aborda o trabalho homônimo, apresentado pela dupla de artistas lituanos Nomeda & Gediminas Urbonas na 52ª Bienal de Veneza, em 2007. O título designa o edifício que até 1940 sediou, em Roma, a primeira embaixada da república independente da Lituania, mantido sob jurisdição das autoridades russas mesmo após a queda do bloco soviético, em 1989, e considerado, pela ex-república soviética, território nacional ocupado. O trabalho implicou na construção de um pombal na Villa Lituania e numa série de ações de conotação política e social em Veneza, Roma e Vilna, cidade onde a dupla reside. Os artistas são conhecidos internacionalmente pela dimensão política e social que pretendem infundir a suas ações. Não obstante a forte carga ideológica que envolveu a intervenção de Nomeda & Gediminas Urbonas na Bienal de Veneza, neste ensaio o autor, tributário da tradição marxista, demonstra notável ceticismo em relação à potência crítica do discurso marxista evocado em parte significativa da arte contemporânea.This text has been originally published in the book Villa Lituania, which approaches the homonymous work presented by the lithuanian artists Nomeda & Gediminas Urbonas, at the 52ª Venice Biennial, in 2007. The title is the name of the building used until 1940 as the seat for the first independent Lithuania Republic's embassy, in Rome, nevertheless kept under the jurisdiction of Russian authorities since the fall of the soviet bloc, in 1989, and considered, by the ex-soviet Republic, national territory under foreign occupation. The work involved the creation of a pigeon loft at Villa Lituania building, as well as a series of actions targeted at social and politic issues in Venice, Rome and Vilnius, where the tandem lives. Socially and politically addressed actions have made the artists internationally known. Notwithstanding the strong ideological drive

  8. Dimensions of Occupational Prestige

    Science.gov (United States)

    Haug, Marie R.; Widdison, Harold A.

    1975-01-01

    Eight dimensions of occupational prestige are examined for their effect on the general prestige ratings accorded various occupations within the medical profession. Stepwise multiple regression analyzes the relative weight of these dimension among 410 persons. The findings suggested that public stereotypes exert a normative pressure on individual…

  9. Leadership and Occupational Stress

    Science.gov (United States)

    Stickle, Fred E.; Scott, Kelly

    2016-01-01

    In a leadership position, it is important to understand what stress is and how it affects others. In an occupational setting, stressors vary according to personality types, gender, and occupational rank. The purpose of this manuscript is to review the foundations of stress and to explore how personality characteristics influence stress.…

  10. The Heath Occupational Model.

    Science.gov (United States)

    Heath, William E.

    1990-01-01

    Career development programs must identify occupational needs of adults. A model based on Maslow's hierarchy develops occupational questions related to individual motivations (physiology, safety, love, esteem, and self-actualization). Individual needs are then compared with characteristics and benefits of proposed jobs, companies, or careers. (SK)

  11. CAUSES OF OCCUPATIONAL INJURIES

    NARCIS (Netherlands)

    KINGMA, J

    1994-01-01

    The causes of occupational injuries (N = 2,365) were investigated. Accidents with machinery and hand tools were the two main causes (49.9%). 89% of the patients with occupational injuries were male. The highest risk group were in the age category of 19 years or less (51.9%). This age group also

  12. [Attitudes of Polish occupational medicine physicians towards a proposal of requirements for occupational medicine training in Europe].

    Science.gov (United States)

    Indulski, J A; Boczkowski, A; Mikulski, M

    1998-01-01

    In order to determine key competences required of occupational medicine specialists, common throughout Europe, a questionnaire has been developed and distributed among several European countries. The questionnaire contained 115 subjects related to 8 fields of activities carried out by occupational medicine physicians (occupational hazards to health, assessment of disability and fitness for work, communications, research methods, management, environmental medicine, occupational health law and ethics, and health promotion). In each of these fields, competences were classified into three following categories: knowledge, experience and skills. Respondents were asked to allocate a score from 0 to 5 for each subject, where 0 = not necessary; 1 = of minimum importance, and 5 = most important or essential. In Poland the questionnaire was distributed among two groups of specialists: group I--experienced specialists in occupational medicine (leading representatives of occupational health care management), and group II--relatively younger and less experienced occupational medicine physicians, participating in the specialist training, organised by The Nofer Institute of Occupational Medicine. A comprehensive analysis of the completed questionnaires was carried out in two dimensions: substantive (the importance of individual competences as perceived by Polish specialists in occupational medicine), and comparative (evaluation and interpretation of similarities and differences between two groups of respondents). A hierarchy of requirements, occupational medicine training in Poland is to satisfy, was reconstructed with two sets of competences, one recognised by respondents as needless and the other recognised as useful with different grades of importance. Some characteristic differences in opinions between two groups studies were highlighted.

  13. Occupational skin diseases

    DEFF Research Database (Denmark)

    Mahler, V; Aalto-Korte, K; Alfonso, J H

    2017-01-01

    in Science and Technology (COST) Action TD 1206 (StanDerm) (www.standerm.eu). RESULTS: Besides a national health service or a statutory health insurance, most European member states implemented a second insurance scheme specifically geared at occupational diseases [insurance against occupational risks......BACKGROUND: Work-related skin diseases (WSD) are caused or worsened by a professional activity. Occupational skin diseases (OSD) need to fulfil additional legal criteria which differ from country to country. OSD range amongst the five most frequently notified occupational diseases (musculoskeletal...... diseases, neurologic diseases, lung diseases, diseases of the sensory organs, skin diseases) in Europe. OBJECTIVE: To retrieve information and compare the current state of national frameworks and pathways to manage patients with occupational skin disease with regard to prevention, diagnosis, treatment...

  14. Occupational stress among dentists

    DEFF Research Database (Denmark)

    Moore, Rod

    2011-01-01

    Dentists report a high degree of occupational stress.(Cooper, Mallinger, and Kahn, 1978;Coster, Carstens, and Harris, 1987;DiMatteo, Shugars, and Hays, 1993;Hakeberg et al., 1992;Möller and Spangenberg, 1996;Moore, 2000;Myers and Myers, 2004;O'Shea, Corah, and Ayer, 1984) This chapter reviews...... the literature of studies that elaborate on the circumstances of occupational stress of dentists. These will include the frequency of occurrence of occupational stress among dentists in several countries, frequency and intensity of identified stressors specific to dentistry, as well as the consequences...... of this occupational stress. The literature on consequences includes effects on dentists' physical health, personal and occupational performance, including "burnout" phenomena, as well as topics of alcohol or substance abuse and reports of suicidal behaviour among dentists. One specific and less conventionally...

  15. Occupational medicine and toxicology

    Directory of Open Access Journals (Sweden)

    Fischer Axel

    2006-02-01

    Full Text Available Abstract This editorial is to announce the Journal of Occupational Medicine and Toxicology, a new Open Access, peer-reviewed, online journal published by BioMed Central. Occupational medicine and toxicology belong to the most wide ranging disciplines of all medical specialties. The field is devoted to the diagnosis, prevention, management and scientific analysis of diseases from the fields of occupational and environmental medicine and toxicology. It also covers the promotion of occupational and environmental health. The complexity of modern industrial processes has dramatically changed over the past years and today's areas include effects of atmospheric pollution, carcinogenesis, biological monitoring, ergonomics, epidemiology, product safety and health promotion. We hope that the launch of the Journal of Occupational Medicine and Toxicology will aid in the advance of these important areas of research bringing together multi-disciplinary research findings.

  16. The Occupations of Literacy: Occupational Therapy's Role

    Science.gov (United States)

    Frolek Clark, Gloria

    2016-01-01

    Nationally, student proficiency in reading and writing is very low and requires ongoing focus from state and local agencies. With almost 25% of occupational therapists working in early intervention and school settings (AOTA, 2015), their role of facilitating literacy (e.g., reading, writing, speaking and listening) is critical. Occupational…

  17. Edad y cultura política

    Directory of Open Access Journals (Sweden)

    MANUEL JUSTEL

    1992-01-01

    Full Text Available En este artículo se analiza la evolución de algunos aspectos de la cultura política y democrática durante los años ochenta: información y competencia política, participación política, actitudes hacia los partidos y orientaciones políticas. Los datos proceden de sendas encuestas realizadas en 1980 y 1989. Mediante análisis de cohortes de edad, controlando sexo y nivel de estudios, se comprueba el grado diferencial de expansión de actitudes democráticas en los grupos de edad, controlando sexo y nivel de estudios, se comprueba el grado diferencial de expansión de actitudes democráticas en los grupos de edad, el efecto homogeneizador que conlleva y el influjo estratégico de la educación. En el marco teórico de la socialización política en edad adulta y de las relaciones entre sistema social y sistema político, se interpretan los cambios de actitudes distinguiendo efectos de ciclo vital, de cohorte y de periodo. Al mismo tiempo, se discuten algunas consecuencias políticas del envejecimiento poblacional y se constata de un grado notable de plasticidad actitudinal y de adhesión creciente a la democracia de las cohortes de edad avanzada.

  18. BURNOUT AND OCCUPATIONAL PARTICIPATION

    Science.gov (United States)

    Eren, Hakan; Huri, Meral; Bağış, Nilsun; Başıbüyük, Onur; Şahin, Sedef; Umaroğlu, Mutlu; Orhan, Kaan

    2016-11-01

    The aim of the present study was to investigate the prevalence of burnout and occupational participation limitation among dental students in a dental school in Turkey. Four hundred fifty-eight dental students (females=153; males=305) were included in the study. The age range varied from 17-to-38 years. Maslach Burnout Inventory-Student Version (MBI-SV) and Canadian Occupational Performance Measure (COPM) were used to gather data. Descriptive analyses, t-test, and Kruskall-Wallis test for independent groups were used for data analyses. The results indicated that 26% of all the students have burnout in terms of emotional exhaustion (25%), cynicism (18%), and academic efficacy (14%). The results showed that burnout is statistically significant in relation to demographics (pstudents showed considerably decreased occupational performance and satisfaction scores, which suggested occupational participation limitations. Occupational performance and satisfaction scores were inversely correlated with emotional exhaustion and cynicism, while directly correlated with reduced academic efficacy (pburnout and occupational participation limitation can be seen among dental students. Students with burnout may also have occupational participation limitation. Enriching dental education programs with different psychological strategies may be useful for education of healthy dentists and improve the quality of oral and dental health services.

  19. Isometric strength and occupational muscle disorders.

    Science.gov (United States)

    Kilbom, A

    1988-01-01

    In two longitudinal studies, initial muscle strength and endurance of the shoulder-forearm muscles were related to deterioration of shoulder-neck-arm disorders after one year. Group I (n = 32) worked in the automobile industry assembling car motors. Their work was performed when standing and walking, and implied varied postures and exertion of external forces. Group II (n = 96) worked in the electronics industry assembling printed circuit boards. They worked sitting down and were exposed mainly to postural static loads. Muscle strength was negatively related to deterioration in group I but no such relationship was found in group II. The mechanism of occupational muscular injury is discussed, and it is suggested that mechanical overstress of the musculoskeletal system causes injury in occupations where external forces are exerted. The mechanism of injury in static, postural loads remains to be explained.

  20. cobalt (ii), nickel (ii)

    African Journals Online (AJOL)

    DR. AMINU

    ABSTRACT. The manganese (II), cobalt (II), nickel (II) and copper (II) complexes of N, N' – bis(benzoin)ethylenediiminato have been prepared and characterized by infrared, elemental analysis, conductivity measurements and solubility. The potentiometric, and elemental analyses studies of the complexes revealed 1:1 ...

  1. Occupational Mortality, Background on

    DEFF Research Database (Denmark)

    Lynge, Elsebeth

    2016-01-01

    in England and Wales from 1851 to 1979–1983, and these studies have provided key data on social inequalities in health. Death certificate studies have been used for identification of occupational groups with high excess risks from specific diseases. Follow-up studies require linkage of individual records......The study of occupational mortality involves the systematic tabulation of mortality by occupational or socioeconomic groups. Three main methods are used to conduct these studies: cross-sectional studies, death certificate studies, and follow-up studies. Cross-sectional studies were undertaken...

  2. The cyclin-dependent kinase 8 module sterically blocks Mediator interactions with RNA polymerase II

    DEFF Research Database (Denmark)

    Elmlund, Hans; Baraznenok, Vera; Lindahl, Martin

    2006-01-01

    CDK8 (cyclin-dependent kinase 8), along with CycC, Med12, and Med13, form a repressive module (the Cdk8 module) that prevents RNA polymerase II (pol II) interactions with Mediator. Here, we report that the ability of the Cdk8 module to prevent pol II interactions is independent of the Cdk8......-dependent kinase activity. We use electron microscopy and single-particle reconstruction to demonstrate that the Cdk8 module forms a distinct structural entity that binds to the head and middle region of Mediator, thereby sterically blocking interactions with pol II....

  3. RNA polymerase II transcriptional fidelity control and its functional interplay with DNA modifications.

    Science.gov (United States)

    Xu, Liang; Wang, Wei; Chong, Jenny; Shin, Ji Hyun; Xu, Jun; Wang, Dong

    2015-01-01

    Accurate genetic information transfer is essential for life. As a key enzyme involved in the first step of gene expression, RNA polymerase II (Pol II) must maintain high transcriptional fidelity while it reads along DNA template and synthesizes RNA transcript in a stepwise manner during transcription elongation. DNA lesions or modifications may lead to significant changes in transcriptional fidelity or transcription elongation dynamics. In this review, we will summarize recent progress toward understanding the molecular basis of RNA Pol II transcriptional fidelity control and impacts of DNA lesions and modifications on Pol II transcription elongation.

  4. Fuels and Petroleum, Oil & Lubricants (POL) Laboratories

    Data.gov (United States)

    Federal Laboratory Consortium — The Fuels and Lubricants Technology Team operates and maintains the Fuels and POL Labs at TARDEC. Lab experts adhere to standardized American Society for Testing and...

  5. Occupational Respiratory Disease

    Science.gov (United States)

    ... time, and duration. A list of previous jobs, hobbies, and smoking habits, if any. Completed occupational health ... Disease Surveillance Last Updated: March 3, 2017 This article was contributed by: familydoctor.org editorial staff Categories: ...

  6. a la política emancipatoria

    Directory of Open Access Journals (Sweden)

    Benjamín Arditi

    2007-01-01

    Full Text Available Este artículo explora la persistencia de la agitación en políticas de emancipación. Polemiza con la caracterización que hace Bismarck acerca de la política como “arte de lo posible” que fue retomada posteriormente como consigna por el realismo político. También toma distancia de las visiones escatológicas de la emancipación del tipo que asociamos con el jacobinismo. El propósito de esto es desestabilizar las fronteras entre lo posible y lo imposible y entre política revolucionaria y no revolucionaria. La agitación no es un remanente incómodo de la política caliente de antaño sino que sobrevive como periferia interna de la política institucional en democracias liberales. Funciona como un síntoma que impide el cierre de la política en un esquema plenamente normalizado o, lo que es igual, la agitación en combinación con la política emancipatoria hace surgir la “acontecimentalidad” del acontecimiento y permite vislumbrar el papel de lo imposible. Esto me permite introducir posteriormente una definición mínima de emancipación como disputa acerca de si las condiciones actuales impulsan o dañan la igualdad y la libertad, y si otro mundo es o no posible.

  7. Signaling pathways differentially affect RNA polymerase II initiation, pausing, and elongation rate in cells.

    Science.gov (United States)

    Danko, Charles G; Hah, Nasun; Luo, Xin; Martins, André L; Core, Leighton; Lis, John T; Siepel, Adam; Kraus, W Lee

    2013-04-25

    RNA polymerase II (Pol II) transcribes hundreds of kilobases of DNA, limiting the production of mRNAs and lncRNAs. We used global run-on sequencing (GRO-seq) to measure the rates of transcription by Pol II following gene activation. Elongation rates vary as much as 4-fold at different genomic loci and in response to two distinct cellular signaling pathways (i.e., 17β-estradiol [E2] and TNF-α). The rates are slowest near the promoter and increase during the first ~15 kb transcribed. Gene body elongation rates correlate with Pol II density, resulting in systematically higher rates of transcript production at genes with higher Pol II density. Pol II dynamics following short inductions indicate that E2 stimulates gene expression by increasing Pol II initiation, whereas TNF-α reduces Pol II residence time at pause sites. Collectively, our results identify previously uncharacterized variation in the rate of transcription and highlight elongation as an important, variable, and regulated rate-limiting step during transcription. Copyright © 2013 Elsevier Inc. All rights reserved.

  8. Different pathways for the nuclear import of yeast RNA polymerase II.

    Science.gov (United States)

    Gómez-Navarro, Natalia; Estruch, Francisco

    2015-11-01

    Recent studies suggest that RNA polymerase II (Pol II) has to be fully assembled before being imported into the nucleus, while other reports indicate a distinct mechanism to import large and small subunits. In yeast, Iwr1 binds to the holoenzyme assembled in the cytoplasm and directs its nuclear entry. However, as IWR1 is not an essential gene, Iwr1-independent pathway(s) for the nuclear import of Pol II must exist. In this paper, we investigate the transport into the nucleus of several large and small Pol II subunits in the mutants of genes involved in Pol II biogenesis. We also analyse subcellular localization in the presence of drugs that can potentially affect Pol II nuclear import. Our results show differences in the cellular distribution between large and small subunits when Pol II biogenesis was impaired. Our data suggest that, in addition to the fully assembled holoenzyme, Pol II subunits can be imported to the nucleus, either independently or as partial assemblies, through different pathways, including passive diffusion for the small subunits. © 2015 Elsevier B.V. All rights reserved.

  9. RNAs nonspecifically inhibit RNA polymerase II by preventing binding to the DNA template.

    Science.gov (United States)

    Pai, Dave A; Kaplan, Craig D; Kweon, Hye Kyong; Murakami, Kenji; Andrews, Philip C; Engelke, David R

    2014-05-01

    Many RNAs are known to act as regulators of transcription in eukaryotes, including certain small RNAs that directly inhibit RNA polymerases both in prokaryotes and eukaryotes. We have examined the potential for a variety of RNAs to directly inhibit transcription by yeast RNA polymerase II (Pol II) and find that unstructured RNAs are potent inhibitors of purified yeast Pol II. Inhibition by RNA is achieved by blocking binding of the DNA template and requires binding of the RNA to Pol II prior to open complex formation. RNA is not able to displace a DNA template that is already stably bound to Pol II, nor can RNA inhibit elongating Pol II. Unstructured RNAs are more potent inhibitors than highly structured RNAs and can also block specific transcription initiation in the presence of basal transcription factors. Crosslinking studies with ultraviolet light show that unstructured RNA is most closely associated with the two large subunits of Pol II that comprise the template binding cleft, but the RNA has contacts in a basic residue channel behind the back wall of the active site. These results are distinct from previous observations of specific inhibition by small, structured RNAs in that they demonstrate a sensitivity of the holoenzyme to inhibition by unstructured RNA products that bind to a surface outside the DNA cleft. These results are discussed in terms of the need to prevent inhibition by RNAs, either though sequestration of nascent RNA or preemptive interaction of Pol II with the DNA template.

  10. Occupational health in Malaysia.

    Science.gov (United States)

    Rampal, Krishna Gopal; Aw, Tar-Ching; Jefferelli, Shamsul Bahrin

    2002-01-01

    This article provides a detailed examination of Malaysian occupational health agencies and their roles in formulating and enforcing standards, promoting occupational health and safety (OSH), and providing advisory services. Available OSH training is described, and the need for policies and personnel in various industries is outlined. Further, the authors discuss how international models and collaboration have influenced Malaysian OSH, and how some successes can be repeated and failures remedied.

  11. Occupancy in continuous habitat

    Science.gov (United States)

    Efford, Murray G.; Dawson, Deanna K.

    2012-01-01

    The probability that a site has at least one individual of a species ('occupancy') has come to be widely used as a state variable for animal population monitoring. The available statistical theory for estimation when detection is imperfect applies particularly to habitat patches or islands, although it is also used for arbitrary plots in continuous habitat. The probability that such a plot is occupied depends on plot size and home-range characteristics (size, shape and dispersion) as well as population density. Plot size is critical to the definition of occupancy as a state variable, but clear advice on plot size is missing from the literature on the design of occupancy studies. We describe models for the effects of varying plot size and home-range size on expected occupancy. Temporal, spatial, and species variation in average home-range size is to be expected, but information on home ranges is difficult to retrieve from species presence/absence data collected in occupancy studies. The effect of variable home-range size is negligible when plots are very large (>100 x area of home range), but large plots pose practical problems. At the other extreme, sampling of 'point' plots with cameras or other passive detectors allows the true 'proportion of area occupied' to be estimated. However, this measure equally reflects home-range size and density, and is of doubtful value for population monitoring or cross-species comparisons. Plot size is ill-defined and variable in occupancy studies that detect animals at unknown distances, the commonest example being unlimited-radius point counts of song birds. We also find that plot size is ill-defined in recent treatments of "multi-scale" occupancy; the respective scales are better interpreted as temporal (instantaneous and asymptotic) rather than spatial. Occupancy is an inadequate metric for population monitoring when it is confounded with home-range size or detection distance.

  12. Occupational health in Mexico.

    Science.gov (United States)

    Carreón, Tania; Santos-Burgoa, Carlos; Baron, Sherry; Hernández, Sendy

    2002-01-01

    The authors discuss the maquiladoras and child labor, and offer an overview of the history of occupational safety and health in Mexico that covers laws and regulations, social security, unions, and enforcement of legislation. The organization and structure of the various institutions responsible for occupational safety and health (OSH), as well as administrative procedures, are described. This article concludes with a list of the new challenges for OSH in Mexico.

  13. Occupational exposures. Annex H

    International Nuclear Information System (INIS)

    1982-01-01

    This Annex focuses on significant changes in the pattern of occupational exposure which have appeared since the 1972 and 1962 reports, and presents information on trends or particular causes of high exposures. A further objective is to clarify the reasons for which the Committee requires data on occupational exposure, and to suggest areas in which better data collection or analysis may be performed. Data are also reviewed on accidents involving the exposure of workers to substantial radiation doses.

  14. Workplace Congruence and Occupational Outcomes among Social Service Workers.

    Science.gov (United States)

    Graham, John R; Shier, Micheal L; Nicholas, David

    2016-06-01

    Workplace expectations reflect an important consideration in employee experience. A higher prevalence of workplace congruence between worker and employer expectations has been associated with higher levels of productivity and overall workplace satisfaction across multiple occupational groups. Little research has investigated the relationship between workplace congruence and occupational health outcomes among social service workers. This study sought to better understand the extent to which occupational congruence contributes to occupational outcomes by surveying unionised social service workers ( n = 674) employed with the Government of Alberta, Canada. Multiple regression analysis shows that greater congruence between workplace and worker expectations around workloads, workplace values and the quality of the work environment significantly: (i) decreases symptoms related to distress and secondary traumatic stress; (ii) decreases intentions to leave; and (iii) increases overall life satisfaction. The findings provide some evidence of areas within the workplace of large government run social welfare programmes that can be better aligned to worker expectations to improve occupational outcomes among social service workers.

  15. Occupational stressors in nursing

    Directory of Open Access Journals (Sweden)

    N. Nikpeyma

    2009-04-01

    Full Text Available Background and aimsNursing provides a wide range of potential workplace stressors as it is  a profession that requires a high level of skill, teamworking in a variety of situations and provision  of 24-hour delivery of care .Occupational stress is a major factor of Staff sickness an  absenteeism.This study investigates the main occupational stressors in nursing profession in the  hope of identification and reducing it.MethodsIn this study a questionnaire consisting of three parts:demoghraphic data,the nurses  background and questions about occupational stress from Revised index fulfilled by 140 nurses.ResultsLack of reward for work well done(48/6%, Heavy workload(46/4% ,lack of Participation in decisions (39/3% , poor Control of work place(38/4%and lack of job  development (36/4% have been the main sources of Occupational stress for nurses.chronic  diseases, Night Shift working and working hours were positively associated with occupstional  stress.Conclusion Analysis indicated that effects of work factors on occupational stress are more than demoghraphic data. The findings of this study can assist health service organisations to provide an attractive working climate in order to decrease side effects and consequences of occupational stress. Furthermore, understanding this situation can help to develop coping strategies in order to reduce work-related stress.

  16. Occupational Experience, Mobility, and Wages

    DEFF Research Database (Denmark)

    Groes, Fane

    In this paper we present how occupational tenure relates to wage growth and occupational mobility in Danish data. We show that the Danish data produces qualitatively similar results as found in U.S. data with respect to an increase in average wages when experience in an occupation increases. In a...... also is true for workers switching occupation and rm. After ve years of experience in an occupation the average probability of switching any type of occupation, including occupation and rm switches, has fallen from 25% to 12%....

  17. Investigating the experiences in a school-based occupational therapy program to inform community-based paediatric occupational therapy practice.

    Science.gov (United States)

    Rens, Lezahn; Joosten, Annette

    2014-06-01

    A collaborative approach with teachers is required when providing community-based occupational therapy to educationally at risk children. Collaborators share common goals and interact and support each other but challenges arise in providing collaborative occupational therapy in settings outside the school environment. The aim of this study was to capture experiences of teachers and occupational therapists working within a school-based occupational therapy program to determine if their experiences could inform collaborative practice. In this pilot study, participant responses to questionnaires (n = 32) about their experiences formed the basis for focus groups and individual interviews. Two focus group were conducted, one with teachers (n = 11) and one with occupational therapy participants (n = 6). Individual interviews were conducted with the supervising occupational therapist, school principal and two leading teachers. Descriptive statistics were used to analyse the data from closed questions, and thematic analysis using a constant comparison approach was used to analyse open ended questions, focus groups and interviews. Three main themes emerged: (i) the need for occupational therapists to spend time in the school, to explain their role, build relationships, understand classroom routines and the teacher role; (ii) occupational therapists need to not see themselves as the expert but develop equal partnerships to set collaborative goals and (iii) occupational therapists advocating for all parties to be informed throughout the occupational therapy process. The pilot study findings identified teacher and therapist experiences within the school setting that could inform improved collaborative practice with teachers and community-based occupational therapists and these findings warrant further investigation. © 2013 Occupational Therapy Australia.

  18. Population Health and Occupational Therapy.

    Science.gov (United States)

    Braveman, Brent

    2016-01-01

    Occupational therapy practitioners play an important role in improving the health of populations through the development of occupational therapy interventions at the population level and through advocacy to address occupational participation and the multiple determinants of health. This article defines and explores population health as a concept and describes the appropriateness of occupational therapy practice in population health. Support of population health practice as evidenced in the official documents of the American Occupational Therapy Association and the relevance of population health for occupational therapy as a profession are reviewed. Recommendations and directions for the future are included related to celebration of the achievements of occupational therapy practitioners in the area of population health, changes to the Occupational Therapy Practice Framework and educational accreditation standards, and the importance of supporting, recognizing, rewarding, and valuing occupational therapy practitioners who assume roles in which direct care is not their primary function. Copyright © 2016 by the American Occupational Therapy Association, Inc.

  19. Rapid Genome-wide Recruitment of RNA Polymerase II Drives Transcription, Splicing, and Translation Events during T Cell Responses

    Directory of Open Access Journals (Sweden)

    Kathrin Davari

    2017-04-01

    Full Text Available Summary: Activation of immune cells results in rapid functional changes, but how such fast changes are accomplished remains enigmatic. By combining time courses of 4sU-seq, RNA-seq, ribosome profiling (RP, and RNA polymerase II (RNA Pol II ChIP-seq during T cell activation, we illustrate genome-wide temporal dynamics for ∼10,000 genes. This approach reveals not only immediate-early and posttranscriptionally regulated genes but also coupled changes in transcription and translation for >90% of genes. Recruitment, rather than release of paused RNA Pol II, primarily mediates transcriptional changes. This coincides with a genome-wide temporary slowdown in cotranscriptional splicing, even for polyadenylated mRNAs that are localized at the chromatin. Subsequent splicing optimization correlates with increasing Ser-2 phosphorylation of the RNA Pol II carboxy-terminal domain (CTD and activation of the positive transcription elongation factor (pTEFb. Thus, rapid de novo recruitment of RNA Pol II dictates the course of events during T cell activation, particularly transcription, splicing, and consequently translation. : Davari et al. visualize global changes in RNA Pol II binding, transcription, splicing, and translation. T cells change their functional program by rapid de novo recruitment of RNA Pol II and coupled changes in transcription and translation. This coincides with fluctuations in RNA Pol II phosphorylation and a temporary reduction in cotranscriptional splicing. Keywords: RNA Pol II, cotranscriptional splicing, T cell activation, ribosome profiling, 4sU, H3K36, Ser-5 RNA Pol II, Ser-2 RNA Pol II, immune response, immediate-early genes

  20. Nature of the Nucleosomal Barrier to RNA Polymerase II | Center for Cancer Research

    Science.gov (United States)

    In the cell, RNA polymerase II (pol II) efficiently transcribes DNA packaged into nucleosomes, but in vitro encounters with the nucleosomes induce catalytic inactivation (arrest) of the pol II core enzyme. To determine potential mechanisms making nucleosomes transparent to transcription in vivo, we analyzed the nature of the nucleosome-induced arrest. We found that the arrests have been detected mostly at positions of strong intrinsic pause sites of DNA.

  1. Occupational health, cognitive disorders and occupational neuropsychology

    Directory of Open Access Journals (Sweden)

    Leonardo Caixeta

    Full Text Available ABSTRACT Work can be an important etiologic factor in the genesis of some mental disorders including cognitive disability. Occupational neuropsychology constitutes an intriguing new but neglected area of research and clinical practice which deals with the neurocognitive consequences of the work environment and work habits. Neuropsychological knowledge is fundamental to understand cognitive requirements of work competence. Work can impact sleep patterns and mental energy, which in turn can cause neuropsychological symptoms. This report presents relevant evidence to illustrate the relationship between work and cognitive dysfunction.

  2. Enabling occupation: occupation-based and client centred practice in Occupational Therapy

    OpenAIRE

    Tatiana Barcelos Pontes; Helene Polatajko

    2016-01-01

    Occupational therapists have always been dedicated to the human occupation study, however the client hasn’t always been seen as an occupational being, with needs, interests and individual goals. The concern for our clients’ engagement in occupation, rather than the acquisition or restoration of performance components, together with the gradual modification of the concept of occupation from work-related activities to purposeful human activity, requires a broadening of our scope of ...

  3. OCCUPATIONAL EXPOSURE AND COPD

    DEFF Research Database (Denmark)

    Würtz, Else Toft

    Chronic Obstructive Pulmonary Disease (COPD) is a common disease. The main risk factor is smoking although 15% of the COPD cases are expected to be preventable if the occupational exposures from vapour, gas, dust, and fume were eliminated; the population attributable fraction (PAF). The thesis ad...... an impact on the development of COPD ought to be transformed to preventive efforts to eliminate occupational COPD and improve public health.......Chronic Obstructive Pulmonary Disease (COPD) is a common disease. The main risk factor is smoking although 15% of the COPD cases are expected to be preventable if the occupational exposures from vapour, gas, dust, and fume were eliminated; the population attributable fraction (PAF). The thesis...... addresses the association between occupational exposure and COPD in a population-based cohort of Danes aged 45-84-years. 4717 participants were included at baseline and 2624 at the four year follow-up. COPD was defined by spirometry and the occupational exposure was based on specialist defined jobs...

  4. Zoonoses as occupational diseases

    Directory of Open Access Journals (Sweden)

    Giorgio Battelli

    2008-12-01

    Full Text Available Zoonoses are discussed as occupational diseases, with special reference to animal husbandry and related activities. After quoting some historical references, occupational zoonoses are examined in relation to the evolution of the concept of occupational zoonosis, the involvement of the World Health Organization in this field, their socio-economic significance, the principal working activities, zoonoses of greatest importance (with special reference to the Mediterranean region, the evaluation of damage and risks. An outline is made of the transmission of zoonoses from farm workers to animals and the biological hazards from the environment. The present situation of occupational zoonoses and related risks in industrialised and traditional farming activities are presented and the importance of some emerging and re-emerging zoonoses for the health of workers is highlighted. The author concludes by stressing that the prevention of occupational zoonoses must be implemented jointly by both veterinary and medical services through preventive measures and epidemiological surveillance of human and animal health, risk evaluation, diagnosis of infections and prompt reporting. It is hoped that the future will offer better inter-disciplinary collaboration and that legislation will be timely and better tailored to safeguard working health and safety.

  5. Occupational health in Argentina.

    Science.gov (United States)

    Werner, A F

    2000-07-01

    Argentina is within the denominated "new industrialised countries", with the characteristic of having high contrasts in the urban population, based on service and industry, and in the rural population, based on agriculture and cattle, still the main sources of wealth in the country. The process of globalisation and the need to compete hard in international markets have provoked high unemployment and the transfer of workers from a formal market to an informal one. Legislation on occupational health is old and it is in the process of being updated. The system of prevention, assistance and compensation for accidents at work and for occupational illnesses has changed from being optative for employers, to the compulsory hiring of private insurance companies. The Government keeps the role of supervisor of the system. There are enough professionals in occupational health, hygiene and safety but not occupational nurses. The teaching is given by many universities and professional associations, some of which have an active profile in the occupational health of the country.

  6. Occupants' window opening behaviour

    DEFF Research Database (Denmark)

    Fabi, Valentina; Andersen, Rune Korsholm; Corgnati, Stefano

    2012-01-01

    systems is proposed, based on studies presented in literature and a general process leading to the effects on energy consumptions is identified.Existing studies on the topic of window opening behaviour are highlighted and a theoretical framework to deal with occupants' interactions with building controls......, aimed at improving or maintaining the preferred indoor environmental conditions, is elaborated. This approach is used to look into the drivers for the actions taken by the occupants (windows opening and closing) and to investigate the existing models in literature of these actions for both residential...... and office buildings. The analysis of the literature highlights how a shared approach on identifying the driving forces for occupants' window opening and closing behaviour has not yet been reached. However, the reporting of variables found not to be drivers may reveal contradictions in the obtained results...

  7. Marketing occupational therapy services.

    Science.gov (United States)

    Kautzmann, L N

    1985-01-01

    The ability to understand and appropriately apply business skills is a key component in the development of a successful private practice. Marketing is one of the business skills occupational therapists need to have in order to take full advantage of the opportunities available to entrepeneurs in the health care industry. The purpose of this article is to present a structured approach to marketing occupational therapy services through the use of a marketing plan. The four components of a marketing plan, a situation analysis, the identification of problems, opportunities, and target markets, the development of a marketing strategy for each targeted market, and a method to monitor the plan, are discussed. Applications to occupational therapy practice are suggested. The use of a marketing plan as a method for organizing and focusing marketing efforts is an effective means of supporting and enhancing the development of a private practice.

  8. Occupational asthma and the paper recycling industry.

    Science.gov (United States)

    Tran, Steven; Francis, Helen; Hoyle, Jennifer; Niven, Robert

    2009-06-01

    Occupational disease linked to the paper recycling industry has not been well documented. No previously confirmed formal diagnosis of occupational asthma (OA) caused by hydroxylamine has been made. We have assessed and performed occupational assessment of eight workers involved in this industry. Two of these were later diagnosed with OA and are reported here. Both workers developed their respiratory symptoms within 2 years of the first use of the chemical hydroxylamine as part of the 'de-inking' process. Hydroxylamine was used as a substitute for glutaraldehyde on risk grounds, although no prior cases of OA had been found. The two workers had worked at the same plant for 11 and 20 years, respectively. Both gave histories of work-related wheeze, shortness of breath and cough. Both cases performed OASYS peak flow records over a 3-week period and had OASYS II index of 2.85 and 2.67, respectively. Both were redeployed on site to non-exposed areas and subsequently demonstrated improvement in bronchial reactivity. Case 2 subsequently consented to and underwent a blinded, placebo-controlled occupational challenge using hydroxylamine demonstrating a significant isolated late asthmatic response. We believe that these are the first two confirmed cases of OA caused by hydroxylamine in the paper recycling industry.

  9. Miscarriage and occupational activity

    DEFF Research Database (Denmark)

    Bonde, Jens Peter; Jørgensen, Kristian Tore; Bonzini, Matteo

    2013-01-01

    . METHODS: A search in Medline and EMBASE 1966-2012 identified 30 primary papers reporting the relative risk (RR) of miscarriage according to ≥1 of 5 occupational activities of interest. Following an assessment of completeness of reporting, confounding, and bias, each risk estimate was characterized as more......, N=10). RR for working hours and standing became smaller when analyses were restricted to higher quality studies. CONCLUSIONS: These largely reassuring findings do not provide a strong case for mandatory restrictions in relation to shift work, long working hours, occupational lifting, standing...

  10. Danger zone: Men, masculinity and occupational health and safety in high risk occupations.

    Science.gov (United States)

    Stergiou-Kita, Mary; Mansfield, Elizabeth; Bezo, Randy; Colantonio, Angela; Garritano, Enzo; Lafrance, Marc; Lewko, John; Mantis, Steve; Moody, Joel; Power, Nicole; Theberge, Nancy; Westwood, Eleanor; Travers, Krista

    2015-12-01

    The workplace is a key setting where gender issues and organizational structures may influence occupational health and safety practices. The enactment of dominant norms of masculinity in high risk occupations can be particularly problematic, as it exposes men to significant risks for injuries and fatalities. To encourage multi-disciplinary collaborations and advance knowledge in the intersecting areas of gender studies, men's health, work and workplace health and safety, a national network of thirteen researchers and health and safety stakeholders completed a critical literature review examining the intersection between masculinities and men's workplace health and safety in order to: (i) account for research previously undertaken in this area; (ii) identify themes that may inform our understanding of masculinity and workplace health and safety and; (iii) identify research and practice gaps in relation to men's workplace health and safety. In this paper we present key themes from this review. Recommendations are made regarding: (i) how to define gender; (ii) how to attend to and identify how masculinities may influence workers' identities, perceptions of occupational risks and how institutionalized practices can reinforce norms of masculinity; (iii) the importance of considering how masculinities may intersect with other variables (e.g. historical context, age, class, race, geographical location) and; (iv) the added significance of present-day labour market forces on men's occupational health and safety.

  11. A visibilidade política na série The Crown

    Directory of Open Access Journals (Sweden)

    Giovana dos Passos Colling

    2018-02-01

    Full Text Available O presente trabalho tem por objetivo compreender como se configura a visibilidade política na trama da série The Crown, produzida pela Netflix, por meio da análise dos três primeiros episódios. A partir do enredo da série, que conta a história da família real britânica na época em que a Raínha Elizabeth II assume o trono e suas novas responsabilidades políticas, é possível perceber e analisar as relações de poder entre a política, a sociedade e a mídia, além de temáticas como imagem pública, escândalo político, relações políticas entre países e discurso midiático. A análise de conteúdo se dá a partir dos autores Gomes, Thompson e Weber. Assim, torna-se perceptível a indissociabilidade entre a mídia, a sociedade e a política para a manutenção de um governo estável, que se utilizando da visibilidade midiática de maneira favorável, estabelece uma comunicação eficiente e uma imagem pública forte e positiva.

  12. Acciones políticas con las que resisten la cultura política tradicional

    Directory of Open Access Journals (Sweden)

    Catalina María Tabares Ochoa

    2013-01-01

    Full Text Available El artículo presenta resultados de la investigación Jóvenes, formación política y participación democrática, cuyo objetivo principal fue identificar los discursos con los cuales los jóvenes reconfiguran la política. La metodología implementada fue la reflexividad dialógica basada en observaciones participantes, talleres de la memoria y entrevistas semiestructuradas, realizadas con jóvenes de Medellín articulados a colectivos artísticos, ecologistas, vegetarianistas, feministas y antimilitaristas. El texto se compone de tres partes: la primera, denominada contextos investigativos, ubica el problema de investigación y el referente teórico de la cultura política en su dimensión interpretativa en la Ciencia Política; la segunda, describe la imagen que del sistema político tienen los jóvenes, para finalmente mostrar cómo con sus acciones debaten y recrean espacios de socialización política como la familia, la iglesia, la escuela, los medios de comunicación y la calle, dotándolos de nuevos sentidos y significados políticos.

  13. Agendamento de Políticas Públicas

    Directory of Open Access Journals (Sweden)

    Rosane Rosa

    2011-07-01

    Full Text Available Aborda-se o conceito de advocacy e contra-agendamento como uma forma de a Sociedade Civil incluir suas causas na mídia, objetivando a tematização e a possibilidade de transformar-se em política pública. Analisa-se a reportagem “Uma conquista longe das ruas”; resultado de um agendamento compartilhado e que, em muitos aspectos, serve de referência para cobertura de políticas públicas sociais.

  14. Políticas y ambiente

    Directory of Open Access Journals (Sweden)

    Nicolás Cuvi

    2013-10-01

    Full Text Available La presente edición de Letras Verdes está dedicada al amplio tema de las interacciones entre las políticas y el ambiente. Las preguntas que planteamos tenían como fin convocar a reflexiones tanto sobre los cambios discursivos en las políticas ambientales en América Latina, como sobre los impactos materiales que éstas han tenido, al suscitar (o no procesos de transformación en la relación que mantenemos con nuestro entorno.

  15. Occupational Orientation: Business, Marketing and Management Occupations. Experimental Curriculum Materials.

    Science.gov (United States)

    Illinois State Office of Education, Springfield.

    These experimental curriculum materials for one of five clusters developed for the occupational orientation program in Illinois include a series of learning activity packages (LAPs) designed to acquaint the student with the wide range of occupational choices available in the business, marketing, and management occupations field. The 31 LAPs, each…

  16. Occupant Controlled Lighting

    DEFF Research Database (Denmark)

    Logadóttir, Ásta

    2011-01-01

    preferences for correlated colour temperature (CCT). The results suggest that the method of adjustment, previously used in the lighting literature, is not adequate to generalize about occupant preferences for illuminance or CCT. Factors that influence occupants’ lighting preference when applying the method...

  17. Coping With Occupational Stress.

    Science.gov (United States)

    O'Brien, Dianne Boswell

    1981-01-01

    Ways of reducing occupational stress include: (1) avoiding the stressful situation; (2) changing the response to the stress; and (3) changing the environment. Administrators can help teachers manage stress by developing communication techniques, steering committees, and support groups. A second part of this article will be published in the January…

  18. Hospitality Occupations. Curriculum Guide.

    Science.gov (United States)

    California State Dept. of Education, Sacramento. Bureau of Homemaking Education.

    This curriculum guide on the hospitality occupations was developed to help secondary and postsecondary home economics teachers prepare individuals for entry-level jobs in the hospitality industry. The content is in seven sections. The first section presents organizational charts of a medium-size hotel, food and beverage division, housekeeping and…

  19. Predicting occupational lung diseases

    NARCIS (Netherlands)

    Suarthana, E.

    2008-01-01

    This thesis aims at demonstrating the development, validation, and application of prediction models for occupational lung diseases. Prediction models are developed to estimate an individual’s probability of the presence or future likelihood of occurrence of an outcome (i.e. disease of interest or

  20. Characterization of Mycobacterium smegmatis PolD2 and PolD1 as RNA/DNA polymerases homologous to the POL domain of bacterial DNA ligase D.

    Science.gov (United States)

    Zhu, Hui; Bhattarai, Hitesh; Yan, Han-Guang; Shuman, Stewart; Glickman, Michael S

    2012-12-21

    Mycobacteria exploit nonhomologous end-joining (NHEJ) to repair DNA double-strand breaks. The core NHEJ machinery comprises the homodimeric DNA end-binding protein Ku and DNA ligase D (LigD), a modular enzyme composed of a C-terminal ATP-dependent ligase domain (LIG), a central 3'-phosphoesterase domain (PE), and an N-terminal polymerase domain (POL). LigD POL is proficient at adding templated and nontemplated deoxynucleotides and ribonucleotides to DNA ends in vitro and is the catalyst in vivo of unfaithful NHEJ events involving nontemplated single-nucleotide additions to blunt DSB ends. Here, we identify two mycobacterial proteins, PolD1 and PolD2, as stand-alone homologues of the LigD POL domain. Biochemical characterization of PolD1 and PolD2 shows that they resemble LigD POL in their monomeric quaternary structures, their ability to add templated and nontemplated nucleotides to primer-templates and blunt ends, and their preference for rNTPs versus dNTPs. Deletion of polD1, polD2, or both from a Mycobacterium smegmatis strain carrying an inactivating mutation in LigD POL failed to reveal a role for PolD1 or PolD2 in templated nucleotide additions during NHEJ of 5'-overhang DSBs or in clastogen resistance. Whereas our results document the existence and characteristics of new stand-alone members of the LigD POL family of RNA/DNA polymerases, they imply that other polymerases can perform fill-in synthesis during mycobacterial NHEJ.

  1. Occupational Therapy's Role with Autism

    Science.gov (United States)

    Fact Sheet Occupational Therapy’s Role with Autism Autism is a lifelong condition associated with a varied course from early childhood through adulthood. Occupational therapy practitioners are distinctly qualified to ...

  2. Occupational causes of male infertility

    DEFF Research Database (Denmark)

    Bonde, Jens P E

    2013-01-01

    To highlight and discuss the new evidence on occupational and environmental risk to male reproductive function.......To highlight and discuss the new evidence on occupational and environmental risk to male reproductive function....

  3. Mission Critical Occupation (MCO) Charts

    Data.gov (United States)

    Office of Personnel Management — Agencies report resource data and targets for government-wide mission critical occupations and agency specific mission critical and/or high risk occupations. These...

  4. Radiation protection in occupational health

    International Nuclear Information System (INIS)

    1987-01-01

    The document is a training manual for physicians entering the field of occupational medicine for radiation workers. Part 1 contains the general principles for the practice of occupational health, namely health surveillance and the role of the occupational physician in the workplace, and Part 2 provides the essential facts necessary to understand the basic principles of radiation physics, radiobiology, dosimetry and radiation effects which form the basis for occupational radiation health

  5. Occupational chronic obstructive pulmonary disease

    DEFF Research Database (Denmark)

    Omland, Oyvind; Würtz, Else Toft; Aasen, Tor Børvig

    2014-01-01

    Occupational-attributable chronic obstructive pulmonary disease (COPD) presents a substantial health challenge. Focusing on spirometric criteria for airflow obstruction, this review of occupational COPD includes both population-wide and industry-specific exposures.......Occupational-attributable chronic obstructive pulmonary disease (COPD) presents a substantial health challenge. Focusing on spirometric criteria for airflow obstruction, this review of occupational COPD includes both population-wide and industry-specific exposures....

  6. Química general II

    OpenAIRE

    Olba Torrent, Amparo

    2018-01-01

    El document forma part dels materials docents programats mitjançant l'ajut del Servei de Política Lingüística de la Universitat de València Temes de l'assignatura: Química general II del primer curs del Grau de Química Topics of the course: General Chemistry II in the first year of the Degree in Chemistry

  7. Occupational Safety and Health in Venezuela.

    Science.gov (United States)

    Caraballo-Arias, Yohama

    2015-01-01

    Venezuela has pioneered a preventive-focused and comprehensive movement for Occupational Safety and Health (OSH) in Latin America. However, despite being an oil-rich country, it has some of the lowest salaries for their workers and highest levels of hyperinflation, devaluation, crime, and violence of the world. Review the current status and challenges on relevant aspects of OSH in Venezuela. Review of literature and documents from national governments, UN agencies, NGOs, and the Venezuelan government concerning OSH and related topics since 1986. Reformed in 2005, the Organic Law on Prevention, Conditions and Environment (LOPCYMAT) was a fundamental moment of change for OSH. Factors which have impacted OSH the strongest are (i) the creation of the National Institute of Occupational Safety and Health (INPSASEL) and (ii) the socioeconomic crisis Venezuela is going through. Venezuela's laws are innovative and yet non-compliance is enormous. Almost half of the population works in the informal sector. Following the International Labor Office projections, 5 people die per day in Venezuela due to occupational accidents or diseases, making health and safety at work a luxury rather than a right. The quality of life for the average worker has deteriorated, affecting not only health but the overall well-being of all Venezuelans. The political and socio-economic situation has led to a mass exodus of more than 1.6 million highly qualified and talented professionals. Many statistics concerning OSH are not updated and are unreliable regarding occupational accidents and diseases. There is a substantial difference between what is written to protect individual Venezuelans in the workplace and the reality of workplace conditions. Substantial governmental actions are needed in the immediate future to improve occupational safety and health of Venezuelan workers. Copyright © 2015 The Author. Published by Elsevier Inc. All rights reserved.

  8. Direct configuration interaction and multiconfigurational self-consistent-field method for multiple active spaces with variable occupations. II. Application to oxoMn(salen) and N2O4

    Science.gov (United States)

    Ivanic, Joseph

    2003-11-01

    In a previous paper, a new direct configuration interaction method for multiple active spaces with variable occupations was described. The present article illustrates how this method may be applied to the oxoMn(salen) complex and the N2O4 molecule. In the first application it is shown how complete-active-space self-consistent-field wave functions of the oxoMn(salen) system may be approximated by a drastically reduced number of configurations with negligible loss of accuracy in terms of energetics. In the second application, to N2O4, it is demonstrated how the fully optimized reaction space wave function may be approximated and also how the recovery of dynamic correlation effects may be achieved. The best predictions of the structure (rNN=1.743 Å, rNO=1.189 Å, ∠(ONO)=134.4°) and binding energy (De=16.0 kcal/mol) are both in very good agreement with experiment (rNN=1.756, rNO=1.191, ∠(ONO)=134.46°, De=16.3 kcal/mol).

  9. Subjetividad política: intersectaciones afrodescendientes

    Directory of Open Access Journals (Sweden)

    Adriana Arroyo-Ortega

    2017-01-01

    Full Text Available En el presente artículo recogemos algunos hallazgos sobre la subjetividad política tomados de una investigación doctoral que se encuentra en curso y que explora la narración de una mujer joven afrodescendiente que, en su acción en un colectivo de la ciudad de Medellín, interroga las prácticas cotidianas de exclusión y precisa los intereses que en su lugar de ubicación ha venido desarrollando. En un primer momento, avanzamos sobre la subjetividad política mediante la reflexión que algunos investigadores e investigadoras han realizado al respecto en relación con lo expresado por esta mujer joven en su acción política, articulado posteriormente con una profundización sobre las implicaciones de la expansión de la subjetividad política de las mujeres jóvenes afrodescendientes, para finalizar con unas líneas conclusivas.

  10. Ingeniero, político, economista, inventor

    Directory of Open Access Journals (Sweden)

    Jimena Montaña Cuéllar

    2001-01-01

    Full Text Available Técnica y utopía. Biografía intelectual y política de Alejandro López, 1876-1940. Alberto Mayor Mora. Fondo Editorial Universidad Eafit, colección Cielos de Arena, Medellín, 2001, 621 págs., il.

  11. El marketing político

    Directory of Open Access Journals (Sweden)

    Alvaro H. Cifuentes G.

    2015-04-01

    Full Text Available RESUMEN Si un candidato desea ser elegido, las técnicas de marketing aplicadas a la política, le son imprescindibles. El marketing político (Politing es el análisis  metódico de los diferentes segmentos que integran el ámbito político de una sociedad y de los factores que puedan modificarlos. Se aplican al candidato, a los votantes, al análisis de la publicidad política, a los simpatizantes, a desconocedores  del partido y a los indecisos. Los candidatos colombianos lo están aplicando, y compañías nuestras exportan servicios  de asesoría de países suramericanos.Promocionar  un candidato implica estructurar una compañía tal como una empresa, aplicando técnicas de ventas, de fijación de cuotas y de planeación estratégica.

  12. Oposición política

    OpenAIRE

    Betancourt, Sergio Raimundo; Centeno, Daniel Félix; Luconi, Leonardo Martín; Viadana, Alejandro Daniel

    1991-01-01

    Fil: Betancourt, Sergio Raimundo. Universidad Nacional de Cuyo. Facultad de Ciencias Políticas y Sociales Fil: Centeno, Daniel Félix. Universidad Nacional de Cuyo. Facultad de Ciencias Políticas y Sociales Fil: Luconi, Leonardo Martín . Universidad Nacional de Cuyo. Facultad de Ciencias Políticas y Sociales Fil: Viadana, Alejandro Daniel. Univer...

  13. Influence of Parents\\' Occupation, Gender and School Location on ...

    African Journals Online (AJOL)

    This study examined the influence of parents\\' occupation, gender and school location on vocational interest among students. The population of the study consisted of senior secondary II students. Three hundred and four (304) SSII students were selected through stratified random sampling technique. The instrument used ...

  14. Trayectorias de vida, trayectorias políticas: ejercicios situados de política encarnada

    Directory of Open Access Journals (Sweden)

    Gabriela Montiel

    2016-08-01

    Full Text Available rayectorias de vida, trayectorias políticas: ejercicios situados de una política encarnada, es una invitación a repensar la política y lo político ubicando como pauta de enunciación los cuerpos. Corporalidades que no se configuran a solas, sino que son atravesadas constantemente por discursos de poder (orden, alimentación, belleza, deseo, movilidad, agencia, subordinación, represión. Esta tesis la fuimos tejiendo mediante la narrativa de vida de la mano del Método Biográfico (Sautu, 2004, la propuesta de investigación feminista del Conocimiento Situado (Haraway, 1989 y en cuanto al cuerpo teórico para el análisis concretamente la línea de reflexión desde los Feminismos decoloniales en relación a las identidades políticas y movimientos sociales (Flórez, 2010 y el Transfeminismo (Álvarez Castillo, 2014; Preciado, 2013; Solá, 2013; Sentamans, 2013. ¿Qué implica encarnar la política? Responder a esta pregunta es el objetivo a lo largo de este diálogo entre tres compañeras artistas y mi persona, posicionando este cuerpo situado como principal pauta de enunciación.

  15. Practical occupational medicine in "practice"

    DEFF Research Database (Denmark)

    Ingemann Larsen, Anders; Schmidt, Jan; Jepsen, Jørgen Riis

    2016-01-01

    In Denmark, the practice of occupational medicine tends to be carried out by specialists in occupational medicine and less so by family physicians. The provision of health service to workers is therefore limited. This constraint may also apply in other developed countries and even more in countries...... with few occupational health resources. This Editorial argues that family physicians are indeed in a position where they can make a major positive difference for their working patients and for the enterprises where they work. Without specialist knowledge in occupational medicine, the family physician...... exposed workers. Such involvement would expand the coverage of occupational health service to patients/workers on a global scale....

  16. Enabling occupation: occupation-based and client centred practice in Occupational Therapy

    Directory of Open Access Journals (Sweden)

    Tatiana Barcelos Pontes

    2016-04-01

    Full Text Available Occupational therapists have always been dedicated to the human occupation study, however the client hasn’t always been seen as an occupational being, with needs, interests and individual goals. The concern for our clients’ engagement in occupation, rather than the acquisition or restoration of performance components, together with the gradual modification of the concept of occupation from work-related activities to purposeful human activity, requires a broadening of our scope of practice. The most current theories related to occupational therapy practice have highlightes the use of client centered and occupational based practices. In occupation-based, client-centred practice the client participates actively in negotiating goals, and client occupational goals are given priority and are placed at the centre of assessment, intervention and outcomes. There are numerous evidences in the literature with significantly positive results supporting these approaches. These approaches are based on the premises that goals and objectives of interventions should be focused in occupation and significant activities to the client and reflect the occupational therapy core values: an occupational-centred perspective that respects client’s choices, goals and values, promoting and supporting the engagement on meaningful activities.

  17. Education and Occupational Outcomes

    DEFF Research Database (Denmark)

    Johnes, Geraint; Freguglia, Ricardo; Spricigo, Gisele

    2016-01-01

    Purpose: The purpose of this paper is to examine the dynamic relationship between policies related to educational provision and both educational participation and occupational outcomes in Brazil, using PNAD and RAIS-Migra data. Design/methodology/approach: Outcomes are examined using: static...... multinomial logit analysis, and structural dynamic discrete choice modelling. The latter approach, coupled with the quality of the RAIS-Migra data source, allows the authors to evaluate the education policy impacts over time. Findings: The main results show that the education level raises the propensity...... that the individual will be in formal sector work or still in education, and reduces the probability of the other outcomes. Transition into non-manual formal sector work following education may, however, occur via a spell of manual work. Originality/value: This is the first study of occupational destination...

  18. Occupational dose constraint

    International Nuclear Information System (INIS)

    Heilbron Filho, Paulo Fernando Lavalle; Xavier, Ana Maria

    2005-01-01

    The revision process of the international radiological protection regulations has resulted in the adoption of new concepts, such as practice, intervention, avoidable and restriction of dose (dose constraint). The latter deserving of special mention since it may involve reducing a priori of the dose limits established both for the public and to individuals occupationally exposed, values that can be further reduced, depending on the application of the principle of optimization. This article aims to present, with clarity, from the criteria adopted to define dose constraint values to the public, a methodology to establish the dose constraint values for occupationally exposed individuals, as well as an example of the application of this methodology to the practice of industrial radiography

  19. MEASURES OF OCCUPATIONAL MISMATCH

    Directory of Open Access Journals (Sweden)

    Monica Mihaela MAER MATEI

    2014-11-01

    Full Text Available The research developed in this paper is based on micro data available in Programme for the International Assessment of Adult Competencies (PIAAC. The research aimed to estimate the size of both forms of labour market mismatch: education mismatch and skill mismatch. The first measure of job mismatch is based on workers’ self-assessment. The second one uses the PIAAC assessment regarding the proficiency for each skill dimension (literacy, numeracy and problem solving in technology rich environments. The labor market mismatch was measured for Spain and Italy datasets for the higher education graduates whose occupations are included in Major Group two Professionals, according to the International Standard Classification of Occupations. The estimation results showed that the two measures of labour market mismatch are not correlated.

  20. Occupational safety motivation

    DEFF Research Database (Denmark)

    Pedersen, Louise; Kines, Pete

    2010-01-01

    Background: Motivation is one of the most important factors for safety behaviour and for implementing change in general. However, theoretical and psychometric studies of safety performance have traditionally treated safety motivation, safety compliance and safety participation unidimensionally....... At the same time many motivation questionnaire items are seldom founded on theory and/or do not account for the theories’ ontological and epistemological differences, e.g. of how knowledge, attitude and action are related. Present questionnaire items tap into occupational safety motivation in asking whether...... or not respondents ‘are’ motivated and whether they feel that safety is important or worthwhile. Another important aspect is ‘what’ motivates workers to comply to and participate in safety. The aim of this article is to introduce a new theory-based occupational safety motivation scale which is validated...

  1. Embracing Creativity in Occupational Therapy

    Directory of Open Access Journals (Sweden)

    Lydia Royeen, MOT, OTR/L

    2015-01-01

    Full Text Available Jen Gash, an occupational therapist and creativity coach living in the UK, provided the cover art for the winter 2015 issue of The Open Journal of Occupational Therapy. The picture is titled “Over the Exe.” Jen uses her inspiration of the Kawa River model in this painting. The painting is of her husband and daughter standing where the river meets the sea. This is a metaphoric representation of rejoining the greater collective. In addition, Jen has a passion for occupational therapists to encompass creativity. A core aspect of occupational therapy is the multi-dimensional concept of occupations; it allows for occupational therapists to incorporate creativity into daily practice. Jen’s goal is for occupational therapy to embrace its creative theoretical roots.

  2. Daily Occupations among asylum seekers

    DEFF Research Database (Denmark)

    Morville, Anne-Le

    2014-01-01

    Asylum seekers often find themselves in a situation where the structure and content of daily occupations have been disrupted and they might have limited access to paid work and education. Studies have shown that asylum seekers experience occupational deprivation and a change in daily occupations...... was to assess whether torture had an influence on the occupational satisfaction and performance, and whether this had changed after ten-months. Forty-three asylum seekers from Afghanistan, Iran and Syria participated at baseline and ten months later 17 were available for inclusion in follow-up studies. Study I......-being and health, all of which had associations to occupational satisfaction, activity level and occupational performance. Torture did not appear to have an influence on satisfaction with daily occupations, but physical torture could be a predictor of decline in ADL motor skills (Study III). On arrival...

  3. Perspective on occupational mortality risks

    International Nuclear Information System (INIS)

    Cohen, B.L.

    1981-01-01

    Occupational risks to radiation workers are compared with other occupational risks on the basis of lost life expectancy (LLE) in a full working lifetime. Usual comparisons with National Safety Council accident death statistics for various industry categories are shown to be unfair because the latter average over a variety of particular industries and occupations within each industry. Correcting for these problems makes some common occupations in some industries 20-50 times more dangerous due to accidents alone than being a radiation worker. If more exposed subgroups of radiation workers are compared with more dangerous subgroups of other occupations, these ratios are maintained. Since radiation causes disease rather than acute injury, a wide range effort is made to estimate average loss of life expectancy from occupational disease; the final estimate for this is 500 days. The average American worker loses more than an order of magnitude more life expectancy from occupational disease than the average radiation worker loses from radiation induced cancer. (author)

  4. PREVENTION OF OCCUPATIONAL ACCIDENTS

    Directory of Open Access Journals (Sweden)

    Jovica Jovanovic

    2004-01-01

    Full Text Available Medical services, physicians and nurses play an essential role in the plant safety program through primary treatment of injured workers and by helping to identify workplace hazards. The physician and nurse should participate in the worksite investigations to identify specific hazard or stresses potentially causing the occupational accidents and injuries and in planning the subsequent hazard control program. Physicians and nurses must work closely and cooperatively with supervisors to ensure the prompt reporting and treatment of all work related health and safety problems. Occupational accidents, work related injuries and fatalities result from multiple causes, affect different segments of the working population, and occur in a myriad of occupations and industrial settings. Multiple factors and risks contribute to traumatic injuries, such as hazardous exposures, workplace and process design, work organization and environment, economics, and other social factors. With such a diversity of theories, it will not be difficult to understand that there does not exist one single theory that is considered right or correct and is universally accepted. These theories are nonetheless necessary, but not sufficient, for developing a frame of reference for understanding accident occurrences. Prevention strategies are also varied, and multiple strategies may be applicable to many settings, including engineering controls, protective equipment and technologies, management commitment to and investment in safety, regulatory controls, and education and training. Research needs are thus broad, and the development and application of interventions involve many disciplines and organizations.

  5. Occupational Health in Mountainous Kyrgyzstan.

    Science.gov (United States)

    Dzhusupov, Kenesh O; Colosio, Claudio; Tabibi, Ramin; Sulaimanova, Cholpon T

    2015-01-01

    In the period of transition from a centralized economy to the market economy, occupational health services in Kyrgyzstan have survived through dramatic, detrimental changes. It is common for occupational health regulations to be ignored and for basic occupational health services across many industrial enterprises and farms to be neglected. The aim of this study was to demonstrate the present situation and challenges facing occupational health services in Kyrgyzstan. The transition from centralized to the market economy in Kyrgyzstan has led to increased layoffs of workers and unemployment. These threats are followed by increased workload, and the health and safety of workers becomes of little concern. Private employers ignore occupational health and safety; consequently, there is under-reporting of occupational diseases and accidents. The majority of enterprises, especially those of small or medium size, are unsanitary, and the health status of workers remains largely unknown. The low official rates of occupational diseases are the result of data being deliberately hidden; lack of coverage of working personnel by medical checkups; incompetent management; and the poor quality of staff, facilities, and equipment. Because Kyrgyzstan is a mountainous country, the main environmental and occupational factor of enterprises is hypoxia. Occupational health specialists have greatly contributed to the development of occupational medicine in the mountains through science and practice. The enforcement of existing strong occupational health legislation and increased financing of occupational health services are needed. The maintenance of credible health monitoring and effective health services for workers, re-establishment of medical services and sanitary-hygienic laboratories in industrial enterprises, and support for scientific investigations on occupational risk assessment will increase the role of occupational health services in improving the health of the working population

  6. Occupational trajectories and occupational cost among Senegalese immigrants in Europe

    Directory of Open Access Journals (Sweden)

    Ognjen Obucina

    2013-03-01

    Full Text Available BACKGROUND Immigration from Africa to Europe has increased substantially in recent decades. The main goal of this paper is to contribute to a better understanding of contemporary international migration processes by analyzing the occupational trajectories and occupational costs of Senegalese immigrants in three major European destination countries (France, Italy, and Spain. OBJECTIVE The first objective is to compare the occupational attainment of the Senegalese immigrants before and after migration to Europe, as well as to establish the determinants of the immigrants' occupational attainment and occupational mobility levels after migration. Another major goal is to estimate the occupational cost of migration from Senegal to Europe. The central question this study intends to answer is how much, in terms of occupational status, Senegalese immigrants renounce by migrating to Europe, in both the short and the long term. METHODS The data stem from the Senegalese sample of the MAFE dataset. The standard OLS techniques are used in the analysis of occupational attainment, while discrete-time multinomial logit is used in the section on occupational mobility. The principal techniques for the estimation of occupational cost of migration are random effects with Mundlak correction and nearest-neighbor matching. RESULTS There is a U-shaped pattern of occupational mobility among Senegalese immigrants in Europe: the average occupational status of this group drops just after arrival in Europe, and then slowly improves with the duration of stay. The multivariate analysis reveals that education acquired in Europe plays an especially important role in the successful participation of this immigrant group in the labor market. The results show that there is a statistically significant occupational cost of migration from Senegal to Europe, but that the cost decreases with the duration of stay in Europe.

  7. Improved occupational performance of young adults with a physical disability after a vocational rehabilitation intervention.

    Science.gov (United States)

    Verhoef, Joan A C; Roebroeck, Marij E; van Schaardenburgh, Natascha; Floothuis, Monique C S G; Miedema, Harald S

    2014-03-01

    The purpose of this study was to investigate into more detail how occupational performance of participants of a 1-year multidisciplinary vocational rehabilitation intervention changed over time, using a broad focus on three areas of occupational performance, addressing work, as well as self-care and leisure. In addition, we explored differences between employed and unemployed persons. In a pre-post-intervention design, changes in occupational performance, addressing work, self-care and leisure, were evaluated using the Canadian Occupational Performance Measure (COPM) and the Occupational Performance History Interview (OPHI-II). Eleven young adults (median 22 years) with physical disabilities participated. Post-intervention, participants experienced fewer problems and showed improved occupational performance in work, as well as self-care and leisure, and improved satisfaction with performance. Participants also showed improved occupational identity and occupational competence, and total scores on OPHI-II. Participants who did not achieve employment did not differ in demographic characteristics. They experienced problems in all three areas of occupational performance at pre-intervention, and more difficulty in interacting in occupational settings (environment). Post-intervention, their levels of occupational identity, competence and settings were similar to those of employed persons. Participants showed improved occupational performance after the intervention. The goal of employment and the broad integrated approach of the intervention seemed to motivate participants to resolve problems in work, as well as self-care and leisure. Unemployed persons faced problems in all three areas of occupational performance at start. Although they seemed to catch up during the intervention, they did not achieve employment within 1 year.

  8. Amor y política.

    OpenAIRE

    Hernando Bernal.

    1998-01-01

    Este trabajo pretende hacer una serie de consideraciones que apuntan sobre todo a extraer una definición de lo que es «la política» para el psicoanálisis a partir de una observación que hace Jacques Alain Miller en su texto Lógicas de la vida amorosa sobre cómo Freud introduce una «teoría política» a partir de su texto Psicología de las masas y análisis del yo.En dicho texto Freud hace ver el poder ordenador y apaciguador del amor) significante amo) en la medida en que una masa no es más que ...

  9. La responsabilidad colectiva ante la crisis moral y política colombiana

    Directory of Open Access Journals (Sweden)

    Rodolfo Arango

    2013-01-01

    Full Text Available En este artículo se aborda en tres pasos la pregunta sobre la responsabilidad que el propio pueblo colombiano tiene frente a la situación de crisis que se vive: (i se explorarán algunos factores que pueden ofrecer luces sobre la actual crisis moral y política de Colombia, (ii se analiza la aceptabilidad de extender el concepto de responsabilidad a colectividades políticas y la importancia que dicha extensión tiene para la construcción de una ética pública, y (iii se sugieren algunos campos de acción que permitan aprender de la actual situación y tomar algunas medidas con miras al fortalecimiento de la democracia.

  10. Hans Kelsen: pensador político

    Directory of Open Access Journals (Sweden)

    Sara Lagi

    2011-01-01

    Full Text Available Hasta la publicación de Sobre la esencia y el valor de la democracia, Hans Kelsen era solo conocido como experto en derecho público. El valor de este artículo de Lagi radica en rescatar de la obra kelseniana un aspecto casi por completo olvidado por la crítica, a saber, sus análisis sobre el significado y las características de la democracia parlamentaria en los Estados modernos. Se aborda la cuestión no solo desde el debate teórico sino también desde su contexto histórico¿político. La teoría política de Kelsen es considerada una parte integral de su doctrina central, presentada en Teoría pura del derecho, su obra más conspicua. Un análisis del trabajo sobre la esencia y el valor de la democracia nos restituye la imagen de un Kelsen como original pensador político. Se analizan las dos ediciones de Sobre la esencia y el valor de la democracia (1920¿1929 con estos propósitos: comprender por qué decidió dedicarse a la teoría de la democracia un teórico que rigurosamente defendió la separación de la esfera jurídica respecto de la historia, la filosofía y la política; y por qué no se limitó a explicar la esencia de la democracia sino que decidió concentrarse en clarificar qué se entiende por valor de la democracia.

  11. Novela policiaca, novela política

    Directory of Open Access Journals (Sweden)

    José Colmeiro

    2015-10-01

    Full Text Available Uno de los aspectos más significativos de la evolución de la novela policiaca en España en la última parte del siglo XX ha sido su transformación en un género político, utilizado a menudo como instrumento de observación social y crítica cultural, así como un espacio de resistencia política y subversión ideológica del statu quo por parte de muchos escritores españoles, durante y después del régimen de Franco. La novela negra ha tendido a ofrecer una visión desestabilizadora del crimen en la sociedad, exponiendo los aspectos represivos, el castigo y el control social, centrándose en poner de manifiesto las causas sociales y políticas subyacentes de la delincuencia. En los últimos años, particularmente con la aparición de un número de escritoras de novela negra y de una mayor sensibilidad hacia planteamientos no heteronormativos, el género ha servido también como espacio de exploración, crítica y subversión de los valores patriarcales y del masculinismo característico de los modelos clásicos, como una nueva forma de autocuestionamiento genérico.

  12. Accompanied consultations in occupational health.

    Science.gov (United States)

    Hobson, J; Hobson, H; Sharp, R

    2016-04-01

    Accompanied consultations are often reported as difficult by occupational physicians but have not been studied in the occupational health setting. To collect information about accompanied consultations and the impact of the companion on the consultation. We collected data on all accompanied consultations by two occupational physicians working in a private sector occupational health service over the course of 16 months. Accompanied consultations were matched to non-accompanied consultations for comparison. We collected data on 108 accompanied consultations. Accompanied consultations were more likely to be connected with ill health retirement (P Occupational health practitioners may benefit from better understanding of accompanied consultations and guidance on their management. © The Author 2015. Published by Oxford University Press on behalf of the Society of Occupational Medicine. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  13. Kanerva's Occupational Dermatology

    DEFF Research Database (Denmark)

    Madsen, Jakob Torp; Andersen, Klaus Ejner

    2012-01-01

    Nanoparticles are ultra small particles less than 100 nm in diameter. Nanoparticles may have altered physical and chemical properties compared to their larger-scale counterparts due to increased surface area. Nanoparticles are used in various industrial products including cosmetics, pharmaceutica......, electronics, paint, and sports equipment. No harmful effects of occupational skin exposure to nanoparticles have been published. Risk assessment must be done on a case-by-case basis for each workplace scenario and for each individual nanoparticle because of lack of knowledge....

  14. Gentrification and Occupancy Rights

    DEFF Research Database (Denmark)

    Huber, Jakob; Wolkenstein, Gregor Fabio

    2018-01-01

    What, if anything, is wrong with gentrification? This paper addresses this question from the perspective of normative political theory. We argue that gentrification is a wrong insofar as it involves a violation of city-dwellers occupancy rights. We distinguish these rights from other forms...... of territorial rights, and discuss the different implications of the argument for urban governance. If we agree on the ultimate importance of being able to pursue one’s located life-plans, the argument goes, we must also agree on limiting the impact on gentrification on people’s lives. Limiting gentrification...

  15. Kanerva's Occupational Dermatology

    DEFF Research Database (Denmark)

    Madsen, Jakob Torp

    Nanoparticles are ultra small particles less than 100 nm in diameter. Nanoparticles may have altered physical and chemical properties compared to their larger-scale counterparts due to increased surface area. Nanoparticles are used in various industrial products including cosmetics, pharmaceutica......, electronics, paint, and sports equipment. No harmful effects of occupational skin exposure to nanoparticles have been published. Risk assessment must be done on a case-by-case basis for each workplace scenario and for each individual nanoparticle because of lack of knowledge....

  16. Genome-wide analysis of KAP1, the 7SK snRNP complex, and RNA polymerase II.

    Science.gov (United States)

    McNamara, Ryan P; Guzman, Carlos; Reeder, Jonathan E; D'Orso, Iván

    2016-03-01

    The transition of RNA polymerase II (Pol II) from transcription initiation into productive elongation in eukaryotic cells is regulated by the P-TEFb kinase, which phosphorylates the C-terminal domain of paused Pol II at promoter-proximal regions. Our recent study found that P-TEFb (in an inhibited state bound to the 7SK snRNP complex) interacts with the KAP1/TRIM28 transcriptional regulator, and that KAP1 and the 7SK snRNP co-occupy most gene promoters containing paused Pol II. Here we provide a detailed experimental description and analysis of the ChIP-seq datasets that have been deposited into Gene Expression Omnibus (GEO): GS72622, so that independent groups can replicate and expand upon these findings. We propose these datasets would provide valuable information for researchers studying mechanisms of transcriptional regulation including Pol II pausing and pause release.

  17. A Conserved Nuclear Cyclophilin Is Required for Both RNA Polymerase II Elongation and Co-transcriptional Splicing in Caenorhabditis elegans.

    Directory of Open Access Journals (Sweden)

    Jeong H Ahn

    2016-08-01

    Full Text Available The elongation phase of transcription by RNA Polymerase II (Pol II involves numerous events that are tightly coordinated, including RNA processing, histone modification, and chromatin remodeling. RNA splicing factors are associated with elongating Pol II, and the interdependent coupling of splicing and elongation has been documented in several systems. Here we identify a conserved, multi-domain cyclophilin family member, SIG-7, as an essential factor for both normal transcription elongation and co-transcriptional splicing. In embryos depleted for SIG-7, RNA levels for over a thousand zygotically expressed genes are substantially reduced, Pol II becomes significantly reduced at the 3' end of genes, marks of transcription elongation are reduced, and unspliced mRNAs accumulate. Our findings suggest that SIG-7 plays a central role in both Pol II elongation and co-transcriptional splicing and may provide an important link for their coordination and regulation.

  18. Occupational exposure to ionizing radiation

    International Nuclear Information System (INIS)

    Snihs, J.O.

    1985-01-01

    An overview of occupational exposure is presented. Concepts and quantities used for radiation protection are explained as well as the ICRP system of dose limitation. The risks correlated to the limits are discussed. However, the actual exposure are often much lower than the limits and the average risk in radiation work is comparable with the average risk in other safe occupations. Actual exposures in various occupations are presented and discussed. (author)

  19. Occupational cancer. 4. enlarged ed.

    International Nuclear Information System (INIS)

    Butz, M.

    1991-01-01

    In the fourth, supplementary edition work related cancer illnesses which from 1978 to 1990 were recognized by the Industrial Professional Associations as occupational diseases are described. This covers: Type of occupational disease, organs affected, causal substances, hazardous professions. In addition, for every occupational-disease, detailed data are presented, e.g. latency periods and ages at death. 16 carcinogenic substances and substance classes are considered in this catalogue including ionizing radiation. (orig./MG) [de

  20. [Occupational allergy to mugwort].

    Science.gov (United States)

    Kurzen, Marina; Bayerl, Christiane; Goerdt, Sergij

    2003-04-01

    Mugwort (Artemisia vulgaris) has traditionally been used as a spice, vegetable and as a herbal medicine. The main representatives of the Artemisia family besides Artemisia vulgaris include Artemisia absinthum and Artemisia dracunculus (estragon). Mugwort pollen allergens are important in triggering late summer and fall pollinosis; in addition cross reactivity occurs between Artemisia vulgaris pollen allergens and celery, carrottes and certain spices belonging to the family of Umbelliferae. A florist with a pre-existing sunflower allergy developed a life-threatening glottal edema after occupational contact with mugwort. She did not suffer from an oral allergy syndrome towards mugwort pollen cross allergens. Skin testing (prick and scratch testing) revealed a strong sensitisation against mugwort and estragon. Specific IgE antibodies against mugwort, sunflower, carrots, celery, fennel and anis were elevated in the peripheral blood. The observation of a severe mugwort allergy with life-threatening complications in a florist underscores the high allergenic potential of Artemisia vulgaris and documents for the first time the occupational significance of this allergy.

  1. Occupation and the relevance of primatology to occupational therapy.

    Science.gov (United States)

    Wood, W

    1993-06-01

    The adaptive functions of occupation during the phylogenetic history of the human species and the ontogenetic development of individual primates re examined through a review of relevant research of wild and captive nonhuman primates. This review suggests that the effectiveness of occupation as a therapeutic medium throughout life span development is fundamentally tied to humankind's phylogenetic history. It is accordingly argued that there is considerable justification to maintain occupational therapy's historical commitment to therapeutic occupation as the profession's primary treatment modality. To support this commitment, questions to guide practice and research are identified that emanate from the primate literature and that are highly germane to the therapeutic process in occupational therapy. These questions address: (a) the relationship between the press of the various environments in which occupational therapists practice and subsequent opportunities availed to patients for engagement in occupation; (b) the relationship between the extent to which patients are or are not empowered to exert real control over their use of time and their eventual development of disabling conditions; and (c) the therapeutic efficacy of occupation as compared with other treatment approaches that are not comparably holistic.

  2. A Polícia e suas Polícias: Clientela, Hierarquia, Soldado e Bandido

    OpenAIRE

    Azevedo, Erika Ferreira de

    2017-01-01

    Resumo A polícia militar representa um braço do Estado e apresenta-se para a população de forma contundente, ostensiva e, por vezes, brutal, não só para a sociedade como para ela mesma. Através da Análise Institucional do Discurso, a pesquisa aqui relatada teve como objetivo estudar os efeitos de reconhecimento e desconhecimento das relações no trabalho que permeiam o discurso de soldados da polícia militar: como estes falam de seu trabalho e, através desta fala, posicionam-se e posicionam su...

  3. Elecciones 2003: spots políticos y cultura política

    OpenAIRE

    Concepción Virriel

    2004-01-01

    El presente trabajo aborda el tema de las elecciones federales de 2003, en especial el fenómeno del abstencionismo. Para ello se vincula el comportamiento electoral en dichas elecciones con la cultura política, en donde los aspectos básicos son la cultura del fraude heredada de los gobiernos priístas y la redefinición de los partidos políticos ante una nueva coyuntura, y cómo éstos aspectos influyeron en la forma de comunicarse mediante sus spots. El análisis de dichos spots comprende el anál...

  4. Precision Machining Technologies. Occupational Competency Analysis Profile.

    Science.gov (United States)

    Ohio State Univ., Columbus. Vocational Instructional Materials Lab.

    This Occupational Competency Analysis Profile (OCAP), which is one of a series of OCAPs developed to identify the skills that Ohio employers deem necessary to entering a given occupation/occupational area, lists the occupational, academic, and employability skills required of individuals entering the occupation of precision machinist. The…

  5. Occupational radiation risk to radiologists

    International Nuclear Information System (INIS)

    Schuettmann, W.

    1981-01-01

    A review is given of the most important publications dealing with attempts to estimate the occupational radiation risk to radiologists by comparing data on their mortality from leukemia and other forms of cancer with respective data for other physicians who were not occupationally exposed to ionizing radiation. (author)

  6. Systematic reviews informing occupational therapy.

    Science.gov (United States)

    Bennett, Sally; Hoffmann, Tammy; McCluskey, Annie; Coghlan, Nicole; Tooth, Leigh

    2013-01-01

    We sought to identify and describe the number, topics, and publishing trends of systematic reviews relevant to occupational therapy indexed in the OTseeker database. We performed a cross-sectional survey of the systematic reviews contained in OTseeker in December 2011. Of the 1,940 systematic reviews indexed in OTseeker, only 53 (2.7%) were published in occupational therapy journals. The most common diagnostic categories were stroke (n = 195, 10.1%) and affective disorders (n = 204, 10.5%). The most common intervention categories were consumer education (n = 644, 33.2%) and psychosocial techniques (n = 571, 29.4%). Only 390 (20.1%) of the 1,940 systematic reviews specifically involved occupational therapy. Occupational therapists need to search broadly to locate relevant systematic reviews or, alternatively, to use databases such as OTseeker. Clarity about the involvement of occupational therapy in reports of future research will improve the ability to identify occupational therapy research for all stakeholders. Finally, occupational therapy practitioners need to read systematic reviews critically to determine whether review conclusions are justified. Copyright © 2013 by the American Occupational Therapy Association, Inc.

  7. Spina bifida and parental occupation

    NARCIS (Netherlands)

    Blatter, B.M.

    1997-01-01

    The aims of this thesis were: (1) to identify parental occupations with an increased risk of spina bifida in offspring; (2) to study whether parental occupational exposure to chemicals or radiation during or shortly before pregnancy is a risk factor for the occurrence of spina bifida. In order to

  8. Occupational ergonomics in space

    Science.gov (United States)

    Stramler, J.

    1992-01-01

    Ergonomics is often defined simply as the study of work. Related or synonymous terms include human factors, human engineering, engineering psychology, and others. Occupational ergonomics is a term that has been proposed to describe the study of the working environment, including the physical consequences resulting from having an improperly designed workplace. The routine space working environment presents some problems not found in the typical Earthbound workplace. These include radiation, intravehicular contamination/pollution, temperature extremes, impact with other objects, limited psychosocial relationships, sensory deprivation, and reduced gravity. These are important workplace considerations, and may affect astronauts either directly at work or at some point during their life as a result of their work under these conditions. Some of the major issues associated with each of these hazards are presented.

  9. Política, violencia y literatura

    Directory of Open Access Journals (Sweden)

    Kohut, Karl

    2002-06-01

    Full Text Available Tomando como punto de partida la opinión general de que América Latina es el continente violento por excelencia y la hipótesis defendida por Ariel Dorfman (1972 se analiza aquí la cuestión de la violencia política, ciñéndose a la literatura de la segunda mitad del siglo XX. Tras discutir las definiciones (divergentes de la violencia propuestas por la filosofía política, se pasa a una fenomenología de la violencia en la literatura, examinando hasta qué punto y en qué sentido ésta sería el carácter distintivo de la literatura latinoamericana. Finalmente, se analiza la metarreflexión sobre la violencia política en la literatura ficcional, centrándose en tres puntos: (1 el (presunto ser violento del mundo latinoamericano, (2 la violencia estatal, y (3 la violencia de la resistencia. Se constata, entre otras cosas, que ha habido una tendencia a atacar la violencia estatal y defender la de la resistencia; tendencia comprensible en tiempos de dictadura, pero que se vuelve problemática bajo una democracia. Dos preguntas cierran este trabajo: hasta qué punto la violencia es un fenómeno de la cultura, que crece en su mismo seno, y no un fenómeno extracultural dirigido contra ella, y hasta dónde la libertad individual y la seguridad cívica pueden ser conciliadas, punto que ha ocupado un lugar central en la discusión internacional después de los acontecimientos del 11 de septiembre.

  10. International Occupational Therapy Research Priorities.

    Science.gov (United States)

    Mackenzie, Lynette; Coppola, Susan; Alvarez, Liliana; Cibule, Lolita; Maltsev, Sergey; Loh, Siew Yim; Mlambo, Tecla; Ikiugu, Moses N; Pihlar, Zdenka; Sriphetcharawut, Sarinya; Baptiste, Sue; Ledgerd, Richard

    2017-04-01

    Occupational therapy is a global profession represented by the World Federation of Occupational Therapists (WFOT). International research priorities are needed for strategic guidance on global occupational therapy practice. The objective of this study was to develop international research priorities to reflect global occupational therapy practice. A Delphi study using three rounds of electronic surveys, distributed to WFOT member organizations and WFOT accredited universities, was conducted. Data were analyzed after each round, and priorities were presented for rating and ranking in order of importance. Forty-six (53%) out of 87 WFOT member countries participated in the Delphi process. Eight research priorities were confirmed by the final electronic survey round. Differences were observed in rankings given by member organizations and university respondents. Despite attrition at Round 3, the final research priorities will help to focus research efforts in occupational therapy globally. Follow-up research is needed to determine how the research priorities are being adopted internationally.

  11. Occupational therapy, culture and diversity

    Directory of Open Access Journals (Sweden)

    Salvador Simó Algado

    2016-01-01

    Full Text Available Occupational behaviour is always an environmental behaviour because the occupation is the dialogue between human beings and their environment. Culture is key dimension in our profession. This article is based on previous research and a new review of the scientific literature on the various meanings associated with culture. In the contemporary context the globalization involves the imposition of the American way of life on a planetary scale. In front of ethnocentrism and racism a diatopical hermeneutics is proposed. A cosmopolitan citizenship can be constructed supporting diversity. The article concludes by reflecting on strategies that can be implemented from occupational therapy to develop a culturally safe occupational therapy. An archaeology of meaning must be developed in front of the Americanization. Occupational therapy needs to develop a powerful political activism in order to build an inclusive society based on human rights and sustainability. Culture and diversity are key elements in this process.

  12. DOE 2012 occupational radiation exposure

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2013-10-01

    The U.S. Department of Energy (DOE) Office of Analysis within the Office of Health, Safety and Security (HSS) publishes the annual DOE Occupational Radiation Exposure Report to provide an overview of the status of radiation protection practices at DOE (including the National Nuclear Security Administration [NNSA]). The DOE 2012 Occupational Radiation Exposure Report provides an evaluation of DOE-wide performance regarding compliance with Title 10, Code of Federal Regulations (C.F.R.), Part 835, Occupational Radiation Protection dose limits and as low as reasonably achievable (ALARA) process requirements. In addition, the report provides data to DOE organizations responsible for developing policies for protection of individuals from the adverse health effects of radiation. The report provides a summary and an analysis of occupational radiation exposure information from the monitoring of individuals involved in DOE activities. Over the past 5-year period, the occupational radiation exposure information is analyzed in terms of aggregate data, dose to individuals, and dose by site.

  13. DOE 2011 occupational radiation exposure

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2012-12-01

    The U.S. Department of Energy (DOE) Office of Analysis within the Office of Health, Safety and Security (HSS) publishes the annual DOE Occupational Radiation Exposure Report to provide an overview of the status of radiation protection practices at DOE (including the National Nuclear Security Administration [NNSA]). The DOE 2011 Occupational Radiation Exposure Report provides an evaluation of DOE-wide performance regarding compliance with Title 10, Code of Federal Regulations (C.F.R.), Part 835, Occupational Radiation Protection dose limits and as low as reasonably achievable (ALARA) process requirements. In addition, the report provides data to DOE organizations responsible for developing policies for protection of individuals from the adverse health effects of radiation. The report provides a summary and an analysis of occupational radiation exposure information from the monitoring of individuals involved in DOE activities. The occupational radiation exposure information is analyzed in terms of aggregate data, dose to individuals, and dose by site over the past five years.

  14. Occupational Trends and Program Priorities

    Directory of Open Access Journals (Sweden)

    Dan Rosenthal

    2001-07-01

    Full Text Available Institutions of higher education that respond to the economic base in their region will remain competitive and be better positioned to obtain public funds and donor support. In addition to mandated program viability standards based on measures such as graduation rate, individual institutions and state coordinating boards can use ten-year occupational trend data to assess future program viability. We used an occupational demand model to determine whether academic programs can meet projected statewide needs for high demand and high growth occupations. For example, computer engineering, the highest growth rate occupation in Alabama, is projected to have 365 annual average job openings, with 93.6% total growth over ten years. But only 46 computer engineering majors graduate annually from all Alabama institutions of higher education. We recommend using an occupational demand model as a planning tool, decision-making tool, and catalyst for collaborative initiatives.

  15. Corporate Cost of Occupational Accidents

    DEFF Research Database (Denmark)

    Rikhardsson, Pall M.; Impgaard, M.

    2004-01-01

    The systematic accident cost analysis (SACA) project was carried out during 2001 by The Aarhus School of Business and PricewaterhouseCoopers Denmark with financial support from The Danish National Working Environment Authority. Its focused on developing and testing a method for evaluating...... occupational costs of companies for use by occupational health and safety professionals. The method was tested in nine Danish companies within three different industry sectors and the costs of 27 selected occupational accidents in these companies were calculated. One of the main conclusions is that the SACA...... method could be used in all of the companies without revisions. The evaluation of accident cost showed that 2/3 of the costs of occupational accidents are visible in the Danish corporate accounting systems reviewed while 1/3 is hidden from management view. The highest cost of occupational accidents...

  16. Proviral HIV-genome-wide and pol-gene specific zinc finger nucleases: usability for targeted HIV gene therapy.

    Science.gov (United States)

    Wayengera, Misaki

    2011-07-22

    Infection with HIV, which culminates in the establishment of a latent proviral reservoir, presents formidable challenges for ultimate cure. Building on the hypothesis that ex-vivo or even in-vivo abolition or disruption of HIV-gene/genome-action by target mutagenesis or excision can irreversibly abrogate HIV's innate fitness to replicate and survive, we previously identified the isoschizomeric bacteria restriction enzymes (REases) AcsI and ApoI as potent cleavers of the HIV-pol gene (11 and 9 times in HIV-1 and 2, respectively). However, both enzymes, along with others found to cleave across the entire HIV-1 genome, slice (SX) at palindromic sequences that are prevalent within the human genome and thereby pose the risk of host genome toxicity. A long-term goal in the field of R-M enzymatic therapeutics has thus been to generate synthetic restriction endonucleases with longer recognition sites limited in specificity to HIV. We aimed (i) to assemble and construct zinc finger arrays and nucleases (ZFN) with either proviral-HIV-pol gene or proviral-HIV-1 whole-genome specificity respectively, and (ii) to advance a model for pre-clinically testing lentiviral vectors (LV) that deliver and transduce either ZFN genotype. First, we computationally generated the consensus sequences of (a) 114 dsDNA-binding zinc finger (Zif) arrays (ZFAs or ZifHIV-pol) and (b) two zinc-finger nucleases (ZFNs) which, unlike the AcsI and ApoI homeodomains, possess specificity to >18 base-pair sequences uniquely present within the HIV-pol gene (ZifHIV-polFN). Another 15 ZFNs targeting >18 bp sequences within the complete HIV-1 proviral genome were constructed (ZifHIV-1FN). Second, a model for constructing lentiviral vectors (LVs) that deliver and transduce a diploid copy of either ZifHIV-polFN or ZifHIV-1FN chimeric genes (termed LV- 2xZifHIV-polFN and LV- 2xZifHIV-1FN, respectively) is proposed. Third, two preclinical models for controlled testing of the safety and efficacy of either of these

  17. La polémica del nacionalismo

    Directory of Open Access Journals (Sweden)

    Germán Posada

    1961-10-01

    Full Text Available La polémica empezó con el artículo de Hernando Téllez, hace veinte días. Con el pretexto de defender a los escritores de su propia generación, a quienes, según él, se viene acusando sistemáticamente de producir una literatura desarraigada y ausente de la vida nacional, Téllez se lanzó a combatir las teorías de " nacionalismo literario'' que actualmente se agitan en Colombia.

  18. Amor y política.

    Directory of Open Access Journals (Sweden)

    Hernando Bernal.

    1998-09-01

    Full Text Available Este trabajo pretende hacer una serie de consideraciones que apuntan sobre todo a extraer una definición de lo que es «la política» para el psicoanálisis a partir de una observación que hace Jacques Alain Miller en su texto Lógicas de la vida amorosa sobre cómo Freud introduce una «teoría política» a partir de su texto Psicología de las masas y análisis del yo.En dicho texto Freud hace ver el poder ordenador y apaciguador del amor significante amo en la medida en que una masa no es más que el amor uniendo a muchas personas y reiterado en cada una de ellas. Las fuerzas armadas y la Iglesia son un buen ejemplo de ello.Pero a pesar de la cohesión amorosa de la humanidad por el poder unificante del amor, resta siempre un malestar. El malestar que persiste en la cultura testimonia del fracaso del amor para resolver el empuje del hombre a satisfacerse con el mal. El significante amo no parece entonces solucionar la paradoja del goce. De aquí que preguntarse sobre adónde vaya el goce en el orden social sea también, para el psicoanálisis, una cuestión política. Jacques- Alain Miller observa, en su texto Lógicas de la vida amorosa, cómo, a partir de la Psicología de las masas y análisis del yo, se puede extraer de Freud una «teoría política», que se vincula muy estrechamente con el amor. Esto porque La Psicología de las masas... enseña sobre el poder ordenador y apaciguador del amor, o mejor, del significante «amor» como significante Amo, lo que se puede escribir de la siguiente manera con ayuda de la «teoría de los discursos» o «teoría del vínculo social» de Lacan.

  19. A course in autoethnography: fostering reflective practitioners in occupational therapy.

    Science.gov (United States)

    Hoppes, Steve; Hamilton, Toby Ballou; Robinson, Cyndy

    2007-01-01

    This paper describes an academic course designed to lay the foundation for reflective practice in occupational therapy. In this course, students conduct highly personalized research based on experiences in Level II fieldwork that leads to writing an autoethnography. The paper describes autoethnography, details its use in occupational therapy literature, and discusses the design and outcomes of the course. Students' experiences with this autobiographical genre of qualitative research are illustrated. In the writing process, students find clinical stories that must be told and learn to "move around" in their stories. The outcomes of the course include integration of personal and professional experiences, closure to academic preparation, and deep reflection about what it means to be an occupational therapist.

  20. 75 FR 23834 - Occupational Information System

    Science.gov (United States)

    2010-05-04

    ... SOCIAL SECURITY ADMINISTRATION [Docket No. SSA-2010-0018] Occupational Information System AGENCY... Administration Occupational Information System, September 2009.'' The complete Panel report (including appendices... to provide independent advice and recommendations on creating an occupational information system...

  1. Políticas de reconhecimento uma novidade das políticas sociais do PT?

    Directory of Open Access Journals (Sweden)

    Krischke, Paulo Jose Duval da Silva

    2004-01-01

    Full Text Available O presente trabalho levanta a hipótese de que as ações de governo do PT estão inovando significativamente na necessária convergência (cf. Fraser, 1999; Honnetch, 2003 entre as tradicionais políticas de redistribuição sócio-econômica, e uma nova diretriz de reconhecimento das diferenças sócio-políticas e culturais. O argumento retoma a trajetória sindical do PT e os efeitos das políticas participativas, nas mudanças da cultura política em várias partes do país. Entre esses efeitos, o crescente apoio à democracia parece relacionar-se ao reconhecimento do direito à diferença e ao pluralismo - principalmente entre a juventude e naqueles locais onde o PT tem governado na última década

  2. Economía Política I, 2010-11

    OpenAIRE

    Antón Pérez, José Ignacio

    2010-01-01

    I. Materiales de clase: Teoría: 0. Conceptos básicos; 1. El problema económico; 2. Las ganancias derivadas del comercio; 3. Elementos básicos de la oferta y la demanda; 4. Elasticidades; 5. La medición del bienestar y la política económica; 6. La empresa: producción, costes y beneficios; 7. Las empresas en los mercados competitivos; Ejercicios: Ejercicios del Tema 2; Ejercicios del Tema 3; Ejercicios del Tema 4; Ejercicios del Tema 5; Ejercicios del Tema 6 y 7; Ejercicios de Repaso. II. Bibli...

  3. Historia del Pensamiento Político Premoderno 05 Fin de la polis. Alejandro Magno

    OpenAIRE

    Sanz Díaz, Benito

    2010-01-01

    Tema 5 El fin de la polis y el surgimiento de nuevas escuelas filosóficas 1.- El declive de la polis griega 2.- Transformación, decadencia y fin de las polis griegas 3.- Filipo II de Macedonia 4.- Alejandro Magno 5.- Helenismo y nuevas concepciones políticas 6.- Epicureismo. Epicuro de Samos 7.- Los cínicos. Ni hogar ni patria, ni ciudad ni ley 8.- El estoicismo. El estoico es un ciudadano del mundo. El cosmopolitismo. La stoa 9.- Las Meditaciones de Marco Aurel...

  4. Van der Pol and the history of relaxation oscillations: Toward the emergence of a concept

    Science.gov (United States)

    Ginoux, Jean-Marc; Letellier, Christophe

    2012-06-01

    Relaxation oscillations are commonly associated with the name of Balthazar van der Pol via his paper (Philosophical Magazine, 1926) in which he apparently introduced this terminology to describe the nonlinear oscillations produced by self-sustained oscillating systems such as a triode circuit. Our aim is to investigate how relaxation oscillations were actually discovered. Browsing the literature from the late 19th century, we identified four self-oscillating systems in which relaxation oscillations have been observed: (i) the series dynamo machine conducted by Gérard-Lescuyer (1880), (ii) the musical arc discovered by Duddell (1901) and investigated by Blondel (1905), (iii) the triode invented by de Forest (1907), and (iv) the multivibrator elaborated by Abraham and Bloch (1917). The differential equation describing such a self-oscillating system was proposed by Poincaré for the musical arc (1908), by Janet for the series dynamo machine (1919), and by Blondel for the triode (1919). Once Janet (1919) established that these three self-oscillating systems can be described by the same equation, van der Pol proposed (1926) a generic dimensionless equation which captures the relevant dynamical properties shared by these systems. Van der Pol's contributions during the period of 1926-1930 were investigated to show how, with Le Corbeiller's help, he popularized the "relaxation oscillations" using the previous experiments as examples and, turned them into a concept.

  5. A transcription fork model for Pol IV and Pol V-dependent RNA-directed DNA methylation.

    Science.gov (United States)

    Pikaard, C S; Haag, J R; Pontes, O M F; Blevins, T; Cocklin, R

    2012-01-01

    In Arabidopsis thaliana, nuclear multisubunit RNA polymerase IV (Pol IV) and RNA-DEPENDENT RNA POLYMERASE 2 (RDR2) are required for the biogenesis of 24-nucleotide small interfering RNAs (siRNAs) that direct DNA methylation and transcriptional silencing at target loci transcribed by nuclear multisubunit RNA polymerase V (Pol V). Pol IV and RDR2 physically associate and RDR2's polymerase activity in vitro is dependent on Pol IV. RDR2 transcription of nascent Pol IV transcripts might result in discontinuous second strands, analogous to lagging-strand Okazaki fragments generated during DNA replication. In vitro, Pol V is unable to displace nontemplate DNA during transcriptional elongation. This suggests a need for DNA duplex unwinding by helper proteins, perhaps analogous to the helicase-mediated duplex unwinding that occurs at replication forks to enable leading strand synthesis by DNA polymerase ε. A multiprotein complex (DRD1, DMS3, DMS11, RDM1) known to enable Pol V transcription might facilitate duplex unwinding via ATP-dependent DNA translocase, single-stranded DNA binding, and cohesin-like strand capture activities. These considerations are discussed and incorporated into a "transcription fork" model for Pol IV and Pol V-dependent RNA-directed DNA methylation.

  6. Dinâmica Institucional, Políticas Públicas e o Desempenho Político Ambiental Brasileiro

    Directory of Open Access Journals (Sweden)

    Diego de Freitas Rodrigues

    2011-12-01

    Full Text Available Este estudo buscou analisar os efeitos da interdependência entre instituições políticas e modelos de desenvolvimento no desempenho de políticas ambientais no Brasil. A hipótese central do trabalho é que, dada a interdependência entre os organismos responsáveis pelas políticas ambientais e padrões de desenvolvimento pouco responsivos à complexidade ambiental, ocorre uma dispersão de poder decisório incentivando o modelo de desenvolvimento de alto carbono. Além de revisão da literatura em Políticas Públicas e Economia Ecológica, foram operacionalizadas (1 uma análise do desenho político-institucional brasileiro e (2 o quadro de gastos públicos do governo federal brasileiro com meio ambiente. Dois resultados foram observados: 1o o desenho e as competências das instituições políticas responsáveis pela formulação e implementação de políticas públicas interferem na maior eficiência de políticas ambientais; 2o quanto maior a abertura institucional, maior a tendência de paralisia decisória na formulação e implementação de políticas públicas ambientais.

  7. Croce, Gramsci e a "autonomia da política"

    Directory of Open Access Journals (Sweden)

    Álvaro Bianchi

    2007-11-01

    Full Text Available Na reflexão que Gramsci desenvolveu nos Quaderni del carcere, o tema da autonomia da política ocupa uma importante posição. Foi com base nessa reflexão que Gramsci desenvolveu sua pesquisa a respeito de política e da possibilidade de uma ciência política. Segundo Benedetto Croce, cabia a Nicolau Maquiavel o mérito de ter afirmado pela primeira vez a autonomia da política. Para Croce, essa autonomia permitia estabelecer uma distinção radical entre ética e política e entre "filosofia da política" e "ciência empírica da política". Gramsci tomou criticamente a reflexão croceana como ponto de partida de sua leitura de Maquiavel. O reconhecimento da autonomia da política implicava que esta não poderia ser reduzida à religião ou à ética. Como campo do conhecimento e como atividade, a ciência política e a política tinham regras próprias, que as distinguiam de outras formas do conhecimento e da atividade humana. Mas tal "autonomia" não implicava, para o marxista sardo, uma separação radical entre política e moral. Por essa razão, Gramsci encontrava em Maquiavel um precursor da filosofia da práxis em sentido pleno, ou seja, o criador de uma "ciência-ação revolucionária".

  8. Adeus à política

    Directory of Open Access Journals (Sweden)

    Manoel Mendonça Filho

    2012-01-01

    Full Text Available O artigo trata as questões do "Estado" e da "Política" partindo do exemplo concreto do processo de institucionalização, no Brasil, de práticas profissionais em psicologia reconhecidas como Análise Institucional (vertente grupalista francesa consideravelmente difundida nos últimos 20 anos. Trabalho para expor uma face menos visível da judicialização que funciona ao nível das concepções, crenças e valores entre os operadores dos equipamentos onde se materializam as políticas públicas engendradas pelo excesso legalista. Dentre as modalidades desse apego à lei, toma-se em análise aquela mais próxima de nossas práticas de funcionalismo público marcando o índice de grau máximo de sua institucionalização: a aceitação consensual da competência como critério de legitimidade na operação dos "instrumentos da violência institucional".

  9. Cultura Política na Antiguidade

    Directory of Open Access Journals (Sweden)

    José Petrúcio Farias Júnior

    2009-06-01

    Full Text Available

    Pretendemos discutir nesse artigo algumas implicações do termo cultura política na Antiguidade, especificamente, na sociedade romana imperial. Dessa forma, acreditamos que as considerações que apresentaremos a seguir contribuam para reflexão da utilização desse termo, produto das investigações contemporâneas, sobre os estudos das sociedades antigas. Para a historiadora Profa. Dra. Margarida Maria de Carvalho, tais reflexões representam ainda uma lacuna na historiografia concernente a essa temática. Isso posto, discorreremos, inicialmente, sobre o conceito de cultura e seus desdobramentos para, em seguida, refletirmos sobre o viés interpretativo que fundamenta estudos históricos que se desenvolvem sob o beneplácito da linha de pesquisa intitulada História e Cultura Política.

  10. Política de los intelectuales

    Directory of Open Access Journals (Sweden)

    Todorov Tzevetan

    1998-06-01

    Full Text Available ¿Qué es un intelectual? Por lo que a mi respecta, limito el uso de este término de la siguiente manera: es un estudioso o un artista (categoria que incluye a los escritores que no se contenta con realizar trabajos cientificos o con la creación de una obra de arte, que no se contenta, por lo tanto, con una méra búsqueda de lo verdadero y con un méro desarrollo de lo bello, sino que siente asimismo comprometido con la noción de bienestar público, con los valores de la sociedad en la que vive, es alguien que participa en el debate sobre esos mismos valores. El intelectual así entendido se halla muy lejos del artista o del estudioso a quienes no preocupan en absoluto las dimensiones políticas o éticas de sus obras; muy lejos también, del predicador o del político profesional, que no crean obra alguna.

  11. Política digital: El uso de Facebook en política electoral en Costa Rica (II

    Directory of Open Access Journals (Sweden)

    Roberto Cruz Romero

    2017-07-01

    Full Text Available Se presenta una continuación al trabajo realizado sobre el uso de Internet en procesos electorales, trazando paralelismos y subrayando las diferencias que subyacen entre la significancia simbólica de una elección presidencial y las elecciones municipales para la ciudadanía. Nuevamente, se recurre a un análisis del comportamiento en redes sociales, Facebook específicamente, y un análisis contextual de la realidad sociopolítica percibida en las distintas localidades, y en cada partido. Se estudiaron 26 partidos inscritos solamente a escala cantonal, y se profundizó en los casos de cinco partidos cantonales que obtuvieron la victoria en la respectiva alcaldía. Esto respalda y robustece la línea de investigación que desde el Programa Sociedad de la Información y el Conocimiento (PROSIC se ha trabajado, en aras de presentar el potencial de la tecnología en la democracia, como un elemento más en la construcción de una sociedad basada en la información y el conocimiento

  12. Occupation and cancer in Britain.

    Science.gov (United States)

    Rushton, L; Bagga, S; Bevan, R; Brown, T P; Cherrie, J W; Holmes, P; Fortunato, L; Slack, R; Van Tongeren, M; Young, C; Hutchings, S J

    2010-04-27

    Prioritising control measures for occupationally related cancers should be evidence based. We estimated the current burden of cancer in Britain attributable to past occupational exposures for International Agency for Research on Cancer (IARC) group 1 (established) and 2A (probable) carcinogens. We calculated attributable fractions and numbers for cancer mortality and incidence using risk estimates from the literature and national data sources to estimate proportions exposed. 5.3% (8019) cancer deaths were attributable to occupation in 2005 (men, 8.2% (6362); women, 2.3% (1657)). Attributable incidence estimates are 13 679 (4.0%) cancer registrations (men, 10 063 (5.7%); women, 3616 (2.2%)). Occupational attributable fractions are over 2% for mesothelioma, sinonasal, lung, nasopharynx, breast, non-melanoma skin cancer, bladder, oesophagus, soft tissue sarcoma, larynx and stomach cancers. Asbestos, shift work, mineral oils, solar radiation, silica, diesel engine exhaust, coal tars and pitches, occupation as a painter or welder, dioxins, environmental tobacco smoke, radon, tetrachloroethylene, arsenic and strong inorganic mists each contribute 100 or more registrations. Industries and occupations with high cancer registrations include construction, metal working, personal and household services, mining, land transport, printing/publishing, retail/hotels/restaurants, public administration/defence, farming and several manufacturing sectors. 56% of cancer registrations in men are attributable to work in the construction industry (mainly mesotheliomas, lung, stomach, bladder and non-melanoma skin cancers) and 54% of cancer registrations in women are attributable to shift work (breast cancer). This project is the first to quantify in detail the burden of cancer and mortality due to occupation specifically for Britain. It highlights the impact of occupational exposures, together with the occupational circumstances and industrial areas where exposures to carcinogenic agents

  13. Economia política da disputa por terras em Minas Gerais

    Directory of Open Access Journals (Sweden)

    Ari Francisco de Araujo Junior

    2008-09-01

    Full Text Available O artigo estuda os determinantes da probabilidade de ocorrência de conflitos de terra, ocupações e assentamentos nos municípios mineiros. Os resultados apontam para a importância de fatores econômicos e políticos. Aparentemente, militantes pró-reforma agrária se adequam ao ciclo político, causando menos conflito em municípios governados por aliados. Por sua vez, a pobreza e o elevado crescimento arrefecem o ímpeto desses militantes.The article analyzes the determinants of the probability of dispute over land (conflicts, occupations and settlement projects in the Brazilian state of Minas Gerais. Through the use of a logit model, we found that the main influences are political and economical ones. Apparently, the behavior of the agrarian reform's supporters follows the political incentive, with fewer occurrences of conflicts in towns governed by political allies. By other hand, the economical determinants - degree of poverty and the economic growth - have negative impacts on it.

  14. Workplace Congruence and Occupational Outcomes among Social Service Workers

    Science.gov (United States)

    Graham, John R.; Shier, Micheal L.; Nicholas, David

    2016-01-01

    Workplace expectations reflect an important consideration in employee experience. A higher prevalence of workplace congruence between worker and employer expectations has been associated with higher levels of productivity and overall workplace satisfaction across multiple occupational groups. Little research has investigated the relationship between workplace congruence and occupational health outcomes among social service workers. This study sought to better understand the extent to which occupational congruence contributes to occupational outcomes by surveying unionised social service workers (n = 674) employed with the Government of Alberta, Canada. Multiple regression analysis shows that greater congruence between workplace and worker expectations around workloads, workplace values and the quality of the work environment significantly: (i) decreases symptoms related to distress and secondary traumatic stress; (ii) decreases intentions to leave; and (iii) increases overall life satisfaction. The findings provide some evidence of areas within the workplace of large government run social welfare programmes that can be better aligned to worker expectations to improve occupational outcomes among social service workers. PMID:27559216

  15. Occupancy models to study wildlife

    Science.gov (United States)

    Bailey, Larissa; Adams, Michael John

    2005-01-01

    Many wildlife studies seek to understand changes or differences in the proportion of sites occupied by a species of interest. These studies are hampered by imperfect detection of these species, which can result in some sites appearing to be unoccupied that are actually occupied. Occupancy models solve this problem and produce unbiased estimates of occupancy and related parameters. Required data (detection/non-detection information) are relatively simple and inexpensive to collect. Software is available free of charge to aid investigators in occupancy estimation.

  16. Wanted: entrepreneurs in occupational therapy.

    Science.gov (United States)

    Anderson, Kristin M; Nelson, David L

    2011-01-01

    The American Occupational Therapy Association (AOTA) has challenged occupational therapy practitioners to advance the profession so that we may become more "powerful" and "widely recognized" by the year 2017 (AOTA, 2007a). To fully achieve this vision, this article argues that the profession should encourage occupational therapy entrepreneurship. As Herz, Bondoc, Richmond, Richman, and Kroll (2005, p.2) stated, "Entrepreneurship may provide us with the means to achieve the outcomes we need to succeed in the current health care environment." This article also argues the urgency of seizing the many opportunities that entrepreneurship offers and recommends specific actions to be taken by AOTA and by therapists.

  17. As armadilhas do tripé da política macroeconômica brasileira

    Directory of Open Access Journals (Sweden)

    ANDRÉ NASSIF

    2015-09-01

    Full Text Available RESUMOEste artigo analisa o chamado tripé da política macroeconômica brasileira, que desde 1999 tem combinado um regime de metas de inflação, um regime de taxa de câmbio flutuante e metas de superávit fiscal primário. A menos que o seu modus operandi seja alterado, o tripé não será capaz de libertar a economia brasileira de outra "possível trindade": altas taxas de juros reais, a apreciação da taxa de câmbio real e crescimento econômico muito baixo. Depois de analisar brevemente a base teórica sob o tripé macroeconômico, o artigo mostra por que este regime de política macroeconômica, se avaliado numa perspectiva de longo ou médio prazo, não tem sido capaz de garantir a estabilidade dos preços nem o crescimento econômico. Além da sugestão de romper com a estratégia brasileira de crescer com poupança externa, o documento também sugere três principais formas de mudar o modus operandi do tripé brasileiro: i aumentar o horizonte de tempo para atingir a meta de inflação, como tem sido o experiência da maioria dos países que adotam esse regime de política monetária; ii restaurar o papel anticíclico da política fiscal brasileira; e iii adotar uma combinação de mecanismos que visem prevenir que a moeda brasileira entre em uma nova tendência cíclica da apreciação em termos reais.

  18. O conceito de liberdade política em Montesquieu

    Directory of Open Access Journals (Sweden)

    Maria Beatriz Nizza da Silva

    1969-06-01

    Full Text Available O primeiro passo na análise do conceito de liberdade política, tal como êle se nos apresenta em De l'esprit des lois, deverá assina-lar uma diferença, fundamental para Montesquieu, entre "liberdade filosófica" e "liberdade política".

  19. Occupational cancer and radiation

    International Nuclear Information System (INIS)

    Brahams, D.

    1988-01-01

    There have been two High Court actions and seven inquests in the UK, with reference to the debate on occupational hazards of long term, low dose exposure. In July, 1987, two cases alleging that workers in the nuclear industry had contracted cancer due to their exposure to radiation at work had to be abandoned halfway through the trial after the judge had heard the medical evidence. A 57-year old man claimed that Hodgkin's disease had been caused by radiation while at work at Sellafield. However, medical opinion was that Hodgkin's disease had never been accepted as caused by radiation. In the second case a man who had died of stomach cancer at the age of 54 after working for UKAEA at Dounreay for 7 years, had received 190 mSv. The defendants' experts rated the likelihood of radiation as the cause at 3-6%; the plaintiffs' experts had suggested 30-50%. Seven inquest juries sitting in West Cumbria from 1983 to 1988 have brought in three verdicts of death caused by an industrial disease, three open verdicts, and one of natural causes. The men had all worked for BNFL at Sellafield for many years. (author)

  20. Historia del Pensamiento Político Premoderno 04 Aristoteles

    OpenAIRE

    Sanz Díaz, Benito

    2010-01-01

    Tema 4 Aristóteles. Política 1.- Aristóteles el Estagirita 2.- Ética y la política en Aristóteles 3.- Las formas de gobierno en La Política 4.- El gobierno democrático es la libertad. 5.- El método Aristotélico. 6.- ¿Qué tipo de Constituciones distingue Aristóteles? 7.- El contexto personal, histórico y político en el que Aristóteles escribe La Política 8.- ¿En que situación se encuentra Grecia en vida de Aristóteles?

  1. History of occupational exposure to natural radioisotopes

    International Nuclear Information System (INIS)

    Steinhausler, F.

    1993-01-01

    From pre-historic times miners represented the group which received, inadvertently, occupational exposure to natural radionuclides. At the end of the 19th century scientists researching the newly found radiation called ''radioactivity'' became exposed frequently to uranium, thorium and their decay chains, still hardly aware of the potential risks associated with their work. In the first half of the 20th century some employees in the radium industry received high doses in the course of their professional duties as chemists, maintenance workers, or radium dial painters; many of them lacked adequate information on radiation protection. After World War II the increased international demand for uranium in the military and civilian sector caused overexposures of several thousands of miners (volunteers, prisoners), mostly due to the inhalation of elevated levels of radon and its decay products. By comparison on an international scale a relatively small number of workers was exposed to increased levels of thorium and its decay products in the thorium and rare-earth extraction industry. Health effects due to these past exposures range from relatively weak associations to statistically significant excesses for a variety of symptoms, such as respiratory diseases or cancer of the bone, lung or pancreas. An assessment of today industrial exposure situations indicates a wide range of occupations exposed to partly significant levels of natural radionuclides. 36 refs., 7 tabs., 3 figs

  2. Occupational Emergency Medicine - Introduction

    Science.gov (United States)

    2011-01-01

    8217ly of ~I(:a l li l pn f ,.,~io ll a l ~ (i n liud ing II ,IL " Ill y (1<..( 1- pJ liOlia l ph ~i~ iam hUI also () llIPBlillnal-f1l’allh o u rw...8217, Ih’Slill llllilirc iml 1I l i,lIly- un’ , " " yh .. d. r"ad t1 ,,’ m ’" ,lJJ’ Mnl I ~1\\6; 1 8:71\\-~{). Ill" Ihere " ’ ld ntla nJl l d q u e~ lio

  3. Occupational Safety and Health Administration

    Science.gov (United States)

    ... Translate UNITED STATES DEPARTMENT OF LABOR Facebook Twitter Instagram RSS Subscribe Search A TO Z INDEX UNITED STATES DEPARTMENT OF LABOR Facebook Twitter Instagram RSS Subscribe Occupational Safety and Health Administration English | ...

  4. Occupational therapy for multiple sclerosis.

    NARCIS (Netherlands)

    Steultjens, E.M.J.; Dekker, J.; Bouter, L.M.; Cardol, M.; Nes, J.C.M. van de; Ende, C.H.M. van den

    2003-01-01

    Background: Multiple sclerosis (MS) patients are referred to occupational therapy with complaints about fatigue, limb weakness, alteration of upper extremity fine motor coordination, loss of sensation and spasticity that causes limitations in performance of activities of daily living and social

  5. DOE 2009 occupational radiation exposure

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2010-09-01

    The U.S. Department of Energy (DOE) Office of Corporate Safety Analysis (HS-30) within the Office of Health, Safety and Security (HSS) publishes the annual DOE Occupational Radiation Exposure Report to provide an overview of the status of radiation protection practices at DOE.* The DOE 2009 Occupational Radiation Exposure Report provides an evaluation of DOE-wide performance regarding compliance with DOE Part 835 dose limits and as low as reasonably achievable (ALARA) process requirements. In addition, the report provides data to DOE organizations responsible for developing policies for protection of individuals from the effects of radiation. The report provides a summary and an analysis of occupational radiation exposure information from the monitoring of individuals involved in DOE activities. The occupational radiation exposure information is analyzed in terms of aggregate data, dose to individuals, and dose by site over the past 5 years.

  6. Occupational contact dermatitis in hairdressers

    DEFF Research Database (Denmark)

    Schwensen, Jakob F; Johansen, Jeanne D; Veien, Niels K

    2014-01-01

    BACKGROUND: Occupational contact dermatitis among hairdressers is frequent, owing to daily exposure to irritants and allergens. OBJECTIVES: To identify sensitization to the most common allergens associated with the occupation of hairdressing. METHODS: Patch test results of 399 hairdressers and 1995...... matched controls with contact dermatitis, registered by the Danish Contact Dermatitis Group between January 2002 and December 2011, were analysed. All patients were patch tested with the European baseline series, and hairdressers were additionally tested with the hairdressing series. RESULTS: Occupational...... with a statistically significant association with the occupation of hairdressing were p-phenylenediamine, thiuram mix, and benzocaine. Frequent sensitizers from the hairdressing series were ammonium persulfate, toluene-2,5-diamine, 3-aminophenol, and 4-aminophenol. Cysteamine hydrochloride and chloroacetamide emerged...

  7. DOE 2010 occupational radiation exposure

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2011-11-01

    The U.S. Department of Energy (DOE) Office of Analysis within the Office of Health, Safety and Security (HSS) publishes the annual DOE Occupational Radiation Exposure Report to provide an overview of the status of radiation protection practices at DOE.* The DOE 2010 Occupational Radiation Exposure Report provides an evaluation of DOE-wide performance regarding compliance with DOE Part 835 dose limits and as low as reasonably achievable (ALARA) process requirements. In addition, the report provides data to DOE organizations responsible for developing policies for protection of individuals from the effects of radiation. The report provides a summary and an analysis of occupational radiation exposure information from the monitoring of individuals involved in DOE activities. The occupational radiation exposure information is analyzed in terms of aggregate data, dose to individuals, and dose by site over the past 5 years.

  8. Sleep in High Stress Occupations

    Science.gov (United States)

    Flynn-Evans, Erin

    2014-01-01

    High stress occupations are associated with sleep restriction, circadian misalignment and demanding workload. This presentation will provide an overview of sleep duration, circadian misalignment and fatigue countermeasures and performance outcomes during spaceflight and commercial aviation.

  9. Spiritual Assessments in Occupational Therapy

    Directory of Open Access Journals (Sweden)

    Barbara Hemphill

    2015-07-01

    Full Text Available Spirituality is recognized as an important concept in the study and practice of medicine, including occupational therapy. This aligns with occupational therapy’s core value of treating people holistically—mind, body, and spirit. Currently, the Joint Commission for the Accreditation of Hospital Organizations ( JCAHO requires that a spiritual assessment be given to patients on admission. To conduct effective spiritual assessments, occupational therapists must distinguish between religion and spirituality. They also must be aware of their own spiritual beliefs and practices and how those might influence their clinical interactions. This article presents spiritual assessment tools that occupational therapists can use in clinical practice; they range from history taking, to questionnaires, to observation scales. Guidelines are presented for selecting among several spiritual assessments. A case study is presented in which a patient’s faith tradition is being challenged, which could affect the outcome of therapy. Finally, treatment and intervention planning and ethical considerations are discussed.

  10. Occupational Health and the Arts.

    Science.gov (United States)

    Hinkamp, David L; McCann, Michael; Babin, Angela

    2017-09-01

    Work in the visual arts, performing arts, and writing can involve exposures to occupational hazards, including hazardous materials, equipment, and conditions, but few art workplaces have strong occupational health resources. Literature searches were conducted for articles that illustrate these concerns. Medical databases were searched for art-related health articles. Other sources were also reviewed, including, unindexed art-health publications, and popular press articles. Information was located that described some exposed populations, art-related hazards, and resulting disorders. Anecdotal reports were used when more complete data were not available. Health hazards in the arts are significant. Occupational health professionals are familiar with most of these concerns and understand their treatment and prevention. The occupational health approach can reduce the health hazards encountered by at-risk art workers. Additional research would benefit these efforts. Resources for further information are available.

  11. Building Bridges Through Meaningful Occupation

    Directory of Open Access Journals (Sweden)

    Jennifer Fortuna

    2017-07-01

    Full Text Available Mary Block, MS, OTR/L, an occupational therapist and artist based in Illinois, provided the cover art for the Summer 2017 issue of The Open Journal of Occupational Therapy (OJOT. Generations is a sculpture made from concrete that measures 240 x100 in. (6.096 x 2.54 m. The piece was commissioned by Mary’s home town, the Village of Deerfield, IL. Mary always knew she wanted to be an artist. When competing paradigms altered Mary’s career path, the field of occupational therapy helped her to shape a new worldview. In uncertain times, meaningful occupation empowered Mary to start over again where she originally began

  12. Going to an Occupational Therapist

    Science.gov (United States)

    ... is to grow , learn, do schoolwork, and play. Occupational therapy (or OT) helps kids who have a physical, sensory, or cognitive disability carry out everyday activities like brushing their teeth or putting on shoes ...

  13. Occupational therapy for rheumatoid arthritis.

    NARCIS (Netherlands)

    Steultjens, E. M.; Dekker, J.; Bouter, L. M.; van Schaardenburg, D.; van Kuyk, M. A.; van den Ende, C. H.

    2004-01-01

    BACKGROUND: For persons with rheumatoid arthritis (RA) the physical, personal, familial, social and vocational consequences are extensive. Occupational therapy (OT), with the aim to facilitate task performance and to decrease the consequences of rheumatoid arthritis for daily life activities, is

  14. Occupational therapy for rheumatoid arthritis.

    NARCIS (Netherlands)

    Steultjens, E.M.J.; Dekker, J.; Bouter, L.M.; Schaardenburg, D.J. van; Kuyk, M.A.H. van; Ende, C.H.M. van den

    2004-01-01

    Background: For persons with rheumatoid arthritis (RA) the physical, personal, familial, social and vocational consequences are extensive. Occupational therapy (OT), with the aim to facilitate task performance and to decrease the consequences of rheumatoid arthritis for daily life activities, is

  15. [Prevention levels in occupational nursing].

    Science.gov (United States)

    Nogueira, Maria Jacyra de Campos

    1982-12-01

    The autor, based in nursing functions concepts of HENDERSON and of HORTA, and in the prevention levels of LEAVELL & CLARK, write about the of the occupational health nursing personnel in Brasil and describes their actions and activities.

  16. DOE 2008 occupational radiation exposure

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2009-10-01

    The U.S. Department of Energy (DOE) Office of Corporate Safety Analysis (HS-30) within the Office of Health, Safety and Security (HSS) publishes the annual DOE Occupational Radiation Exposure Report to provide an overview of the status of radiation protection practices at DOE. The DOE 2008 Occupational Radiation Exposure Report provides an evaluation of DOE-wide performance regarding compliance with DOE Part 835 dose limits and as low as reasonably achievable (ALARA) process requirements. In addition, the report provides data to DOE organizations responsible for developing policies for protection of individuals from the effects of radiation. This report provides a summary and an analysis of occupational radiation exposure information from the monitoring of individuals involved in DOE activities. The occupational radiation exposure information is analyzed in terms of aggregate data, dose to individuals, and dose by site over the past 5 years.

  17. Sleep as an Occupational Need.

    Science.gov (United States)

    Tester, Nicole J; Foss, Joanne Jackson

    In the same way the human body requires food, hydration, and oxygen, it also requires sleep. Even among healthy people, the amount and quality of sleep substantially influence health and quality of life because sleep helps regulate physiological functioning. Given the impact of sleep on participation, the American Occupational Therapy Association reclassified sleep from an activity of daily living to an occupational domain. Poor sleep is a frequent medical complaint, especially among populations with neurological impairment. Occupational therapy practitioners should consider routinely screening for factors affecting their clients' sleep. By addressing such factors, as well as related routines and habits, practitioners can enhance the effectiveness of rehabilitation, promote health and well-being, and increase engagement and life quality. Practitioners should acknowledge the importance of sleep in practice, and the study of sleep should be prioritized by researchers in the field to meet client needs and establish evidence for interventions. Copyright © 2018 by the American Occupational Therapy Association, Inc.

  18. Occupational health and the radiographer

    International Nuclear Information System (INIS)

    Stronach, T.

    1990-01-01

    This paper identifies some of the occupational health hazards faced by radiographers in the hospital environment. There has been very little work done in this area in the past, and as the subject is so large this paper can do little other than raise some of the issues . The hazards addressed include: radiation, ergonomics, chemical, environmental, biological, occupational injury and accident, stress. 14 refs., 2 figs

  19. A política da Igreja Universal e seus reflexos nos campos religioso e político brasileiros

    Directory of Open Access Journals (Sweden)

    Oro Ari Pedro

    2003-01-01

    Full Text Available Este texto versa sobre a inserção da Igreja Universal do Reino de Deus (IURD na política nacional e seus efeitos nos campos religioso e político. Em razão da eficácia de seu carisma institucional, a Universal procedeu, dentro do próprio grupo religioso, a uma ressemantização do ato de votar em particular e da percepção da política em geral, inscrevendo-os em sua lógica religiosa. Isso é uma importante chave explicativa para o elevado grau de fidelidade de votos e o êxito político cada vez maior constatado nas últimas eleições. Ademais, a prática política da Universal está produzindo um efeito mimético em outra igrejas evangélicas, que tendem a imitar seu modelo de fazer política. Sua inserção política, sobretudo por intermédio do Partido Liberal, não passa despercebida pelos partidos, constituindo-se, assim, em um ator relevante na atual conjuntura política brasileira.

  20. Occupation and cancer in Britain

    Energy Technology Data Exchange (ETDEWEB)

    Rushton, L.; Bagga, S.; Bevan, R.; Brown, T.P.; Cherrie, J.W.; Holmes, P.; Fortunato, L.; Slack, R.; Van Tongeren, M.; Young, C.; Hutchings, S.J. [University of London Imperial College of Science Technology & Medicine, London (United Kingdom)

    2010-04-27

    Prioritising control measures for occupationally related cancers should be evidence based. We estimated the current burden of cancer in Britain attributable to past occupational exposures for International Agency for Research on Cancer (IARC) group 1 (established) and 2A (probable) carcinogens. We calculated attributable fractions and numbers for cancer mortality and incidence using risk estimates from the literature and national data sources to estimate proportions exposed. 5.3% (8019) cancer deaths were attributable to occupation in 2005 (men, 8.2% (6362); women, 2.3% (1657)). Attributable incidence estimates are 13, 679 (4.0%) cancer registrations (men, 10 063 (5.7%); women, 3616 (2.2%)). Occupational attributable fractions are over 2% for mesothelioma, sinonasal, lung, nasopharynx, breast, non-melanoma skin cancer, bladder, oesophagus, soft tissue sarcoma, larynx and stomach cancers. Asbestos, shift work, mineral oils, solar radiation, silica, diesel engine exhaust, coal tars and pitches, occupation as a painter or welder, dioxins, environmental tobacco smoke, radon, tetrachloroethylene, arsenic and strong inorganic mists each contribute 100 or more registrations. Industries and occupations with high cancer registrations include construction, metal working, personal and household services, mining, land transport, printing/publishing, retail/hotels/restaurants, public administration/defence, farming and several manufacturing sectors. 56% of cancer registrations in men are attributable to work in the construction industry (mainly mesotheliomas, lung, stomach, bladder and non-melanoma skin cancers) and 54% of cancer registrations in women are attributable to shift work (breast cancer).

  1. Occupational risk of building construction

    International Nuclear Information System (INIS)

    Aneziris, O.N.; Topali, E.; Papazoglou, I.A.

    2012-01-01

    This paper presents the quantification of occupational risk of a building construction project. Risk assessment is based on the Occupational Risk Model (ORCA) developed under the Workgroup Occupational Risk Model project (WORM), in the Netherlands, for quantifying occupational risk. This model assesses occupational risk of a worker, by taking into account his various tasks, activities and their hazards. Risk is evaluated for three types of consequences: recoverable injury, permanent injury and death. The occupational risk model is based on a set of 63 bowties, which assess risk owing to different hazards such as fall from ladder, scaffold, roofs, falling object, struck by moving vehicle, contact by moving parts, etc. ORCA calculates the risk profile of a building construction site, consisting of thirty-eight workers in different job positions, such as operators of excavators, loaders, compaction equipment, workers in excavation and framing phases, etc. All risk profiles of workers have been quantified and jobs have been ranked according to their risk. Workers installing timber formworks have the highest fatality risk (1.57×10 −3 /yr), followed by the workers installing reinforcement (1.52×10 −3 /yr).

  2. The cost of occupational dose

    International Nuclear Information System (INIS)

    Fleishman, A.B.; Clark, M.J.

    1980-01-01

    The optimization of radiological protection will routinely involve the balancing of public and occupational exposure, particularly within the nuclear fuel cycle. For example the reduction of public exposure from an effluent stream could lead to increases in occupational exposure from treatment, storage and disposal operations. A methodology is propased for the estimation of the cost of occupational exposure in the UK (Pound man-Sv -1 ) based on valuations of changes in risk. A variable value for the cost of the occupational man-Sv is obtained depending on per caput dose levels. The values at particular per caput dose levels are different for occupational workers and the general public, because of different demography and assumptions on risk perception and aversion. They are however approximately the same when the per caput doses are expressed as percentages of the dose limits for workers and the general public respectively. An example of the application of the derived cost of the occupational man-Sv to an optimisation problem is given. (author)

  3. Occupational dermatoses: An Asian perspective

    Directory of Open Access Journals (Sweden)

    Riti Bhatia

    2017-01-01

    Full Text Available Occupational dermatoses contribute to a significant portion of work-related diseases, especially in Asia, where a major portion of the workforce is in the unorganized sector. This review article is focussed on the frequency and pattern of occupational skin diseases reported across Asian countries and type of allergens implicated in different occupations. The literature was searched systematically using key words 'occupational dermatoses,' 'occupational skin disease' and name of each Asian country. Ninty five full-text articles were considered relevant and evaluated. Some of the dermatoses seen in industrial workers in Asian countries are similar to those in Western countries, including dermatoses due to chromate in construction and electroplating workers, epoxy resin, and chromate in painters, wood dust in workers in the furniture industry, azo dyes in textile workers and formaldehyde and chromates in those working in the leather and dyeing industries, dermatoses in domestic workers, chefs and health-care workers. Dermatoses in workers engaged in agriculture, beedi (tiny cigars manufacture, agarbatti (incense sticks production, fish processing, carpet weaving, sanitation and those working in coffee plantations and coal mines appear to be unique to Asian countries. Recognition of clinical patterns and geographic variations in occupational skin diseases will provide an impetus to further strengthen future research in these areas, as well as improving their management.

  4. Fathers' occupation and pregnancy outcome

    International Nuclear Information System (INIS)

    McDonald, A.D.; McDonald, J.C.; Armstrong, B.; Cherry, N.M.; Nolin, A.D.; Robert, D.

    1989-01-01

    Findings from a survey of 56,067 women in Montreal on maternal occupation and pregnancy outcome have been reported. Paternal occupation recorded in the same survey was analysed for spontaneous abortion in 24 occupational groups retaining the six main sectors of maternal occupation and allowing, by means of logistic regression, for seven potentially confounding variables. In only one of the 24 fathers' occupational groups was there a statistically significant excess of spontaneous abortions-mechanics, repairers, and certain assemblers (O/E = 1.10, 90% CI = 1.02-1.20); subdivision of this group suggested that this excess was mainly attributable to the large group of motor vehicle mechanics (O/E = 1.17). No significant excess of known chromosomally determined defects was found in any of the 24 occupational groups. An association of developmental defects was found with food and beverage processing (18 defects observed compared with 8.02 expected; p < 0.05); however, there was no specificity in type of food, beverage, or congenital defect, and no obvious explanatory mechanism. (author)

  5. Taxonomic Approaches to Enlisted Occupational Classification. Volume II,

    Science.gov (United States)

    1979-12-01

    located in hyperspace as a function of its values on the set of dimensions used to describe it. Those samples which are located in the same general...Wing) 41 1.6 80.5 Administrative PO/CPO 39 1.5 82.0 Test Cell Operator 32 1.3 83.3 Tool Room PO 30 1.2 84.5 Check Crew Leader 29 1.1 85.6 Line...Dollies 523 20.4 Spray Gun 512 19.9 Chain Fall 495 19.3 Pressure Regulators 489 19.0 Vacuum Cleaner 481 18.7 Impact Wrench 464 18.1 Fuel Cell Removal

  6. Occupational Socialization Processes of Classroom Teachers

    Science.gov (United States)

    Kucukbayram, Canan; Ottekin Demirbolat, Ayse

    2017-01-01

    Purpose: Occupational socialization is a process by which individuals internalize occupational culture. The aim of the present study was to ascertain the views and perceptions of classroom teachers regarding the efficiency of occupational socialization periods and the level of their occupational socialization, and to describe the same by sex and…

  7. Industrial Occupations. Education for Employment Task Lists.

    Science.gov (United States)

    Lake County Area Vocational Center, Grayslake, IL.

    The duties and tasks found in these task lists form the basis of instructional content for secondary, postsecondary, and adult occupational training programs for industrial occupations. The industrial occupations are divided into eight clusters. The clusters and occupations are: construction cluster (bricklayer, carpenter, building maintenance…

  8. Occupational exposure in MRI.

    Science.gov (United States)

    McRobbie, D W

    2012-04-01

    This article reviews occupational exposure in clinical MRI; it specifically considers units of exposure, basic physical interactions, health effects, guideline limits, dosimetry, results of exposure surveys, calculation of induced fields and the status of the European Physical Agents Directive. Electromagnetic field exposure in MRI from the static field B(0), imaging gradients and radiofrequency transmission fields induces electric fields and currents in tissue, which are responsible for various acute sensory effects. The underlying theory and its application to the formulation of incident and induced field limits are presented. The recent International Commission on Non-Ionizing Radiation Protection (ICNIRP) Bundesministerium für Arbeit und Soziales and Institute of Electrical and Electronics Engineers limits for incident field exposure are interpreted in a manner applicable to MRI. Field measurements show that exposure from movement within the B(0) fringe field can exceed ICNIRP reference levels within 0.5 m of the bore entrance. Rate of change of field dB/dt from the imaging gradients is unlikely to exceed the new limits, although incident field limits can be exceeded for radiofrequency (RF) exposure within 0.2-0.5 m of the bore entrance. Dosimetric surveys of routine clinical practice show that staff are exposed to peak values of 42 ± 24% of B(0), with time-averaged exposures of 5.2 ± 2.8 mT for magnets in the range 0.6-4 T. Exposure to time-varying fields arising from movement within the B(0) fringe resulted in peak dB/dt of approximately 2 T s(-1). Modelling of induced electric fields from the imaging gradients shows that ICNIRP-induced field limits are unlikely to be exceeded in most situations; however, movement through the static field may still present a problem. The likely application of the limits is discussed with respect to the reformulation of the European Union (EU) directive and its possible implications for MRI.

  9. Pb II

    African Journals Online (AJOL)

    Windows User

    ., 2009) biomaterials. However, the ..... reported for various microorganisms by various researchers (Gong et al., 2005). At biomass ... the increase in initial Pb (II) was also observed for removal of Pb (II) by loofa sponge immobilized Aspergillus.

  10. Occupational therapy practice in emergency care: Occupational therapists' perspectives.

    Science.gov (United States)

    Spang, Lisa; Holmqvist, Kajsa

    2015-01-01

    Emergency care takes place in a complex work environment that is characterized by critically ill patients, short hospital stays, and a wide variety of different healthcare professionals. Studies of occupational therapists' (OTs) experiences of working within emergency care have shown that they often experience difficulties in explaining the essence of occupational therapy and have to justify their approaches. Much effort has been made in Sweden to help OTs dispel the notion that occupational therapy is difficult to explain, and the aim of this study was to describe how Swedish OTs perceive their work in emergency care. A qualitative descriptive approach was taken, and 14 interviews were conducted with OTs working in emergency care. Qualitative content analysis was used to analyse the data. The overall theme that emerged was "Feeling established through deliberate occupation-based work". The underlying categories showed different strategies used by the OTs to provide occupational therapy in an emergency care context. Deliberate strategies were used to demonstrate the effectiveness of occupational therapy and its approaches to patients and other health care professionals, and this resulted in the OTs feeling both established and needed. Unlike the OTs in previous studies, the Swedish OTs experienced no difficulties in explaining occupational therapy and could make convincing arguments for their interventions. Parallel to their clinical work, the OTs worked with on-going development to find ways to improve their approaches. In summary, these Swedish OTs seem to have been provided with a professional language and the knowledge required to establish themselves in an emergency care setting.

  11. [Occupational risks during pregnancy: Feedback from occupational medical services].

    Science.gov (United States)

    Henrotin, J-B; Vaissière, M; Etaix, M; Dziurla, M; Malard, S; Lafon, D

    2018-01-01

    To describe the follow-up of pregnancies at work and exposures to pregnancy occupational hazards. A cross-sectional study was performed between January and December 2014 in occupational health services of Languedoc-Roussillon region. Eligible workers were interviewed by occupational health physicians (OHPs) after delivery and at the time of returning to work (exposure, anticipation, prevention, communication, sick leave). Occupational skill levels were classified according to the French standard classification of occupations (version 2003) from the French National Institute of Statistics. Socioeconomic deprivation was assessed using the Evaluation of Deprivation and Inequalities in Health Examination (EPICES) individual scale. A total of 1347 workers were recruited. The mean age was at 30.7±4.5 years. Among pregnant workers, there were 54.2% of employees, 30.7% of intermediate occupations, 10.4% of managers and, 4.7% of manual workers. Twenty-two percent of workers were classed as deprived. Also, 43.2% of workers were exposed to three or more occupational hazards during pregnancy. Only 17.7% of workers had medical visits with OHP during pregnancy and 14.7% benefited from workstation adjustments. In contrast, the level of sick leaves was high (74.2%). Our results argue for the need to follow pregnancies at work. However, the low level of prevention activities and the high level of sick leaves raise the question of the management of pregnant women at work. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  12. A Polícia e suas Polícias: Clientela, Hierarquia, Soldado e Bandido

    Directory of Open Access Journals (Sweden)

    Erika Ferreira de Azevedo

    Full Text Available Resumo A polícia militar representa um braço do Estado e apresenta-se para a população de forma contundente, ostensiva e, por vezes, brutal, não só para a sociedade como para ela mesma. Através da Análise Institucional do Discurso, a pesquisa aqui relatada teve como objetivo estudar os efeitos de reconhecimento e desconhecimento das relações no trabalho que permeiam o discurso de soldados da polícia militar: como estes falam de seu trabalho e, através desta fala, posicionam-se e posicionam sua clientela, sua hierarquia, seu objeto de trabalho (os “bandidos” e eles próprios. Buscou-se também analisar que lugar a violência ocupou neste discurso. Dez soldados da polícia militar do Estado de São Paulo foram entrevistados e a transcrição destas estrevistas foi analisada. A partir das análises, é possível refletir sobre a dubiedade do verdadeiro objetivo do trabalho policial, deslizando facilmente do cuidado da população desamparada ao cuidado de si, desamparado sob a pressão da farda.

  13. Occupational deprivation in an asylum centre:

    DEFF Research Database (Denmark)

    Morville, Anne-Le; Erlandsson, Lena-Karin

    2013-01-01

    This article presents a study of three asylum-seeking men from Iran and Afghanistan. It aimed to explore how and if they experienced occupations as occupations in a Danish asylum centre and how their life experience shaped their choice and value of current occupations. In-depth narrative interviews...... explored the participants’ occupational history and its influence on their occupations in the asylum centre. A thematic analysis showed that the participants had been subjected to occupational disruption and deprivation by politically oppressive systems even before their flight. Their occupations...... in Denmark were to a certain extent influenced by their earlier occupations and the current occupational deprivation they all experienced was due to limited possibilities in the centre. Although they tried their best to fill their days and create structure, there was a loss of valued occupations...

  14. (II) complexes

    African Journals Online (AJOL)

    activities of Schiff base tin (II) complexes. Neelofar1 ... Conclusion: All synthesized Schiff bases and their Tin (II) complexes showed high antimicrobial and ...... Singh HL. Synthesis and characterization of tin (II) complexes of fluorinated Schiff bases derived from amino acids. Spectrochim Acta Part A: Molec Biomolec.

  15. Occupationally Based Disaster Medicine

    Science.gov (United States)

    2011-01-01

    whether appropria ll’ pJ tit:llt arc ca n be ct ’Ii or ’.1, Evny ED employl’l’ tllll’ J’ll’ l’ lb "Iledst I n JW IT- n ess cO llrs(.’ in di saster I...Pns tJ llnd drL ’ Ihe mOSI V.1IU.ll>k rCSOll f C , hUI l’l’ f ’ Onn I nlll Sp ’Cil ic::til I Irained I, ) w ork (( gel lter ill I ’a rn s [o r d is...Y e m ergen 1201, In any ca c, DC lIpal ionai medici n re ou r e hould be meci Lo moniLO r the a f ·ty, h ’a lth . alld perf rm n ct ’ oJ 1:: 0

  16. Aonde vai a teoria política?

    Directory of Open Access Journals (Sweden)

    Terence Ball

    2004-11-01

    Full Text Available Neste texto o autor propõe uma reavaliação da Teoria Política, a partir da constatação de sua "morte" e, ao mesmo tempo, da revalorização da disciplina a partir de meados dos anos 1970. A resposta do autor consiste em estabelecer uma distinção entre teorizações de primeira e segunda ordens, isto é, entre reflexões sobre as condições gerais de vida política em comum e o estudo dessas reflexões. Em seguida, o autor indica como os fatores que desvalorizaram a teorização normativa em décadas anteriores - em particular a Ciência Política comportamentalista - declinaram, ao mesmo tempo em que novas questões relativas à vida política em comum (nos Estados Unidos: a Guerra do Vietnã, o movimento pelos direitos civis, o movimento feminista puseram na ordem do dia a disciplina da Teoria Política. O autor encerra o texto lembrando a importância do trabalho em conjunto dos cientistas políticos "empíricos" e dos teóricos políticos "normativos", como sendo relativos a dois aspectos estreitamente relacionados de um mesmo fenômeno - como cientistas e como cidadãos.

  17. Uncovering your hidden occupancy costs.

    Science.gov (United States)

    Apgar, M

    1993-01-01

    Senior managers at large companies may not believe that they can have much impact on the "bricks and mortar" of their cost structure. They may even think that occupancy costs are too insignificant to worry about, too technical to analyze, and too fixed to control. But as real estate consultant Mahlon Apgar argues, occupancy costs can hurt a company's earnings, share value, and overall performance. On the other hand, every dollar saved drops straight to the bottom line. Shearson Lehman Brothers, for example, has found that it can save as much as $20 million annually by reducing occupancy costs in its branch offices and headquarters. Managing occupancy costs isn't easy. But it is timely. As companies strive to improve productivity by consolidating functions and downsizing staff, they are saddled with excess office space. Expansions abroad present completely different market conditions that put a premium on reducing occupancy costs. At the same time, the changing nature of work is challenging deeply held beliefs about the workplace, and, consequently, traditional expectations of office space are giving way to innovations that are less costly and more productive. To manage occupancy costs, managers must be able to identify their components, measure their impact, understand what drives them, and develop options to change them. Four basic tools help diagnose problems: a cost history, a loss analysis, a component analysis, and a lease aging profile. Understanding cost drivers like leasing, location, and layout can give executives the insights they need to reduce occupancy costs while improving the effectiveness of facilities to support day-to-day operations.

  18. The selection of occupancy factors

    International Nuclear Information System (INIS)

    Lakey, J.R.A.

    1977-01-01

    An estimate of the proportion of time that an area is occupied by radiation workers is often used in radiological protection to permit relaxation of exposure rate limits above those for continuous occupation. This proportion is known as an occupancy factor and is used most frequently in X-ray facilities. The strategy for controlling the external exposure of radiation workers must be decided before occupancy factors are selected for the design of the radiation protection facilities. When shielding has to be designed the occupancy factor effects the design objectives and permits increased exposure rates at the shield surface. It is useful to note that the selection of occupancy factors with due regard to the expected spatial variation of the exposure rate can help to reduce the range of the worker's radiation exposure because field gradients are usually steeper close to the shield. When other hazards, such as internal exposure, and other constraints, such as cost of the space consumed, are added, the selection of the optimum set of occupancy factors is more difficult. Two zone occupancy factors are discussed in this paper and proposals are made for a strategy to be used when there is more than one hazard and the designer has to meet constraints imposed by limitations of the facilities available. An important feature of the strategy is the avoidance of high radiation exposure to small groups of workers. The errors involved in assessment of the actual dose received by the radiation worker must be taken into account and in particular the selection of the higher exposure rate limits must be made with attention to the accident potential

  19. Occupational diseases in Poland, 2012

    Directory of Open Access Journals (Sweden)

    Urszula Wilczyńska

    2013-06-01

    Full Text Available Background: The aim of the paper was to present basic statistical data on occupational diseases diagnosed in 2012. Material and Methods: The work was based on the data from "Occupational Disease Reporting Forms" received by the Central Register of Occupational Diseases in 2012. The data comprised information on nosologic units, gender and age of patients, duration of occupational exposure, sections of the national economy and voivodeships. The incidence was specified in terms of the number of cases in relation to paid employees or to employed people. Results: The number of occupational diseases accounted for 2402 cases. The incidence rate was 23 cases per 100 000 paid employees. In spite of the general decline in the number of cases, the incidence of infectious and parasitic diseases increased by 8.6%. The highest incidence was noted for infectious and parasitic diseases (6.8/100 000, pneumoconioses (5.5/100 000, hearing loss (2.1/100 000, diseases of: the peripheral nervous system (2/100 000, voice disorders (1.9/100 000 and the musculo-skeletal system pathologies (1.1/100 000. The pathologies specified above accounted in total for 84% of all occupational diseases. The industrial sectors of the national economy characterized by the highest incidence included mining and quarrying (288.3/100 000 and manufacturing (27.8/100 000. The highest incidence was recorded in the Silesian (46.2/100 000 and the lowest in the Opolskie (4.2/100 000 voivodeships. Conclusions: The downward trend in the incidence of occupational diseases continues. Different incidence of voice disorders among teachers in individual provinces suggests that uniform preventive, diagnostic and certification standards are missing. Med Pr 2013;64(3:317–326

  20. Hannah Arendt e a Liberdade na Política

    Directory of Open Access Journals (Sweden)

    Juliana Scherdien Amaral

    2016-12-01

    Full Text Available Hannah Arendt (1906-1975 a partir do "Fenômeno do Totalitarismo", refletiu sobre a importância da política e do agir político, momento em que é necessário que haja “liberdade política”, nos termos dela. A liberdade é entendida por Arendt como a manifestação do ser humano no espaço público, cujo aparecimento é mediado pela linguagem sem coação, na pluralidade, na singularidade, visando a ação. A ausência da liberdade pode provocar experiências nada edificantes para a existência do homem, como os fatos do Nazismo, por exemplo – campos de concentração e de extermínio, a mentira política, entre outros. Nesse sentido, é preciso compreender como Arendt entende a liberdade, momento em que surge a questão: como a liberdade é (ou pode ser condição para a política? Por quê? Na concepção dela, "o sentido da política é a liberdade". Para tanto, ela distingue a liberdade política da filosófica. A liberdade política precisa da presença de seres humanos que pensem e julguem, que escolham e ajam, e seu exercício será efetivo, e não um mero comportamento. Arendt enfatiza, em seus estudos, a liberdade política, pois para ela a liberdade corresponde à possibilidade de agir.

  1. Extending Beyond Qualitative Interviewing to Illuminate the Tacit Nature of Everyday Occupation: Occupational Mapping and Participatory Occupation Methods.

    Science.gov (United States)

    Huot, Suzanne; Rudman, Debbie Laliberte

    2015-07-01

    The study of human occupation requires a variety of methods to fully elucidate its complex, multifaceted nature. Although qualitative approaches have commonly been used within occupational therapy and occupational science, we contend that such qualitative research must extend beyond the sole use of interviews. Drawing on qualitative methodological literature, we discuss the limits of interview methods and outline other methods, particularly visual methods, as productive means to enhance qualitative research. We then provide an overview of our critical ethnographic study that used narrative, visual, and observational methods to explore the occupational transitions experienced by immigrants to Canada. We describe our use of occupational mapping and participatory occupation methods and the contributions of these combined methods. We conclude that adopting a variety of methods can enable a deeper understanding of the tacit nature of everyday occupation, and is key to advancing knowledge regarding occupation and to informing occupational therapy practice.

  2. Serie Umbral Político - Num 4.

    OpenAIRE

    Equipo Programa de Estudios de Opinión

    2005-01-01

    Desde el espacio que hemos venido construyendo en Umbral Político, lanzamos una mirada atenta, con espíritu crítico y un profundo sentimiento democrático, a la coyuntura electoral actual. Acompañamos, pues, en primer lugar a la ciudadanía costarricense y a las fuerzas políticas democráticas que participan en este proceso electoral, haciendo un sencillo aporte al proceso de elucidación, información y formación política, que el deber y el amor cívico nos imponen, como universitarios y como ciud...

  3. Historia del pensamiento político moderno (02 Maquiavelo)

    OpenAIRE

    Sanz Díaz, Benito

    2010-01-01

    Tema 2.- Nicolás Maquiavelo. El Príncipe 1. Nicolás Maquiavelo (1469-1527). Nicolás Maquiavelo en el contexto político de la época. 2. Maquiavelo, pensador político. El Galileo de la política.3. Maquiavelo y El príncipe: mito y realidad. Un libro maldito. 4. Hito y mito de la modernidad. 5. Maquiavelo, notario de la realidad de su tiempo. Lectura para comentario en clase. Citas.

  4. Elementos para una política de seguridad urbana

    OpenAIRE

    Sanguino Páez, Antonio

    2016-01-01

    La seguridad es central en la agenda estatal por su relación con derechos ciudadanos en un Estado de Derecho. Este trabajo entra al debate sobre seguridad, aporta elementos en políticas públicas de seguridad urbana y da instrumentos metodológicos para su gestión. Además revisa la política de seguridad de Bogotá en 20 años, examina enfoques, identifica lecciones y formula recomendaciones para una política de seguridad urbana. El fin de la guerra fría y la Doctrina de Seguridad Nacional generó ...

  5. Política em Rousseau: Utopia e Realismo

    OpenAIRE

    Eduardo Leonel Corrêa Cardoso

    2014-01-01

    Diante da diversidade de registros deixados pelo pensador Jean-Jacques Rousseau, a dissertação que se segue propõe analisar sua filosofia política de acordo com duas chaves de leitura política: a utopia e o realismo. Com base nas referências de utopia como transgressão e realismo como redução de danos, encontradas em Renato Janine Ribeiro, pretende-se encontrar uma convergência/aproximação dessas duas tradições de pensamento político no pensamento de Rousseau que se pressupõe transitar justa...

  6. Arma del contrapoder: Humor político y medios

    OpenAIRE

    César Ulloa Tapia

    2008-01-01

    El humor político en los medios de comunicación tiene enorme acogida en las audiencias ya que logra lo que pueden editoriales, análisis académicos y demás espacios de opinión. Es la mejor manera de denunciar, advertir, sancionar e incluso develar lo que hace o deja de hacer el poder político. El humor político está considerado como contrapoder. El periodismo que usa el humor es eficaz, tanto en el mensaje como en su efecto, pues describe las situaciones y recurre a comparaciones y símiles....

  7. Occupational asthma caused by palladium

    Energy Technology Data Exchange (ETDEWEB)

    Daenen, M.; Rochette, F.; Demedts, M.; Nemery, B. [K.U. Leuven, Pneumology (Belgium); Rogiers, P. [A.Z. St-Lucas, Brugge (Belgium); Walle, C. Van de [Siemens, Oostkamp (Belgium)

    1999-01-01

    Occupational exposure to complex platinum salts is a well-known cause of occupational asthma. Although there is evidence that platinum refinery workers may also be sensitized to other precious metals, such as palladium or rhodium, no instances of occupational asthma due to an isolated sensitization to palladium have been reported. A case is reported of occupational rhinoconjunctivitis and asthma in a previously healthy worker exposed to the fumes of an electroplating bath containing palladium. There was no exposure to platinum. Sensitization to palladium was documented by skin-prick tests. The skin-prick test was positive with Pd(NH{sub 3}){sub 4}Cl{sub 2}, but not with (NH{sub 4}){sub 2}PdCl{sub 4}. Corresponding salts of platinum were all negative. A bronchial provocation test with Pd(NH{sub 34})Cl{sub 2} (0.0001 % for a total of 315 s, followed by 0.001 % for a total of 210 s) led to an early decrease in forced expiratory volume in one second (-35%). A similar exposure (0.001 % for a total of 16 min) in an unrelated asthmatic gave no reaction. This case shows that an isolated sensitization to palladium can occur and that respiratory exposure to palladium is a novel cause of metal-induced occupational asthma. (au) 24 refs.

  8. DOE 2013 occupational radiation exposure

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2014-11-01

    The Office of Analysis within the U.S. Department of Energy (DOE) Office of Environment, Health, Safety and Security (EHSS) publishes the annual DOE Occupational Radiation Exposure Report to provide an overview of the status of radiation protection practices at DOE (including the National Nuclear Security Administration [NNSA]). The DOE 2013 Occupational Radiation Exposure Report provides an evaluation of DOE-wide performance regarding compliance with Title 10, Code of Federal Regulations (C.F.R.), Part 835, Occupational Radiation Protection dose limits and as low as reasonably achievable (ALARA) process requirements. In addition, the report provides data to DOE organizations responsible for developing policies for protection of individuals from the adverse health effects of radiation. The report provides a summary and an analysis of occupational radiation exposure information from the monitoring of individuals involved in DOE activities. Over the past five-year period, the occupational radiation exposure information has been analyzed in terms of aggregate data, dose to individuals, and dose by site.

  9. Occupational skin cancer and precancer

    Directory of Open Access Journals (Sweden)

    Fifinela Raissa

    2016-12-01

    Full Text Available Occupational skin cancer and precancerous lesions are skin disorders caused by exposure to chemical carcinogens such as polycyclic hydrocarbons and arsenic, or radiation, such as ultraviolet light and ionizing light in the workplace. Annual increase in skin cancer incidence is believed to be related to various factors such as frequent intense sunlight exposure (i.e. at work, recreational activities, and sun-tanning habit, ozone depletion, an increase in number of geriatric population, and an increase of public awareness in skin cancer. The most common occupational skin cancers are basal cell carcinoma, squamous cell carcinoma, and melanoma. Examples of occupational precancerous lesion of the skin are actinic keratosis and Bowen’s disease. Particular diagnostic criteria to diagnose occupational diseases has been developed. Early detection of occupational skin cancer and precancerous lesion is necessary. An effective prevention program consists of primary prevention such as prevention of hazardous material exposure, secondary prevention such as early detection of disease for early intervention, and tertiary prevention such as minimizing long-term impact of the disease.

  10. Occupational burnout among nursing personel

    Directory of Open Access Journals (Sweden)

    Sylwia Wieder-Huszla

    2016-02-01

    Full Text Available Background. Occupational stress and the related burnout syndrome is undoubtedly one of the most important challenges for public health. Objectives . The objective of the study was identifying occupational burnout among nurses. Material and methods . The questionnaire was responded by 408 professionally active male and female nurses, working in the territory of the West Pomeranian Voivodeship. In the evaluation of occupational burnout the standardized Maslach Burnout Inventory (MBI was applied. Results . Mean values of the level of occupational burnout for the study group amounted to 39.3 ± 30.9 with regard to emotional exhaustion, 30.64 ± 27.89 with respect to the depersonalization subscale and 66.26 ± 27.94 – the lowered level of job satisfaction. Conclusions . 1. The studied nursing personnel showed symptoms of occupational burnout in all dimensions of the syndrome, i.e. high levels of emotional exhaustion and depersonalization as well as low job satisfaction. 2. Individuals with higher education scored lower on the emotional exhaustion scale. 3. Emotional exhaustion is influenced by workplace and position.

  11. Modeling Single Occupant Vehicle Behavior in High-Occupancy Toll (HOT) Facilities

    Science.gov (United States)

    2009-12-14

    High-occupancy toll (HOT) lanes are in operation, under construction, and planned for in several major metropolitan areas. The premise behind HOT lanes is to allow single occupant vehicles (SOVs) to access high occupancy vehicle (HOV) lanes (and theo...

  12. Occupational hazard evaluation model underground coal mine based on unascertained measurement theory

    Science.gov (United States)

    Deng, Quanlong; Jiang, Zhongan; Sun, Yaru; Peng, Ya

    2017-05-01

    In order to study how to comprehensively evaluate the influence of several occupational hazard on miners’ physical and mental health, based on unascertained measurement theory, occupational hazard evaluation indicator system was established to make quantitative and qualitative analysis. Determining every indicator weight by information entropy and estimating the occupational hazard level by credible degree recognition criteria, the evaluation model was programmed by Visual Basic, applying the evaluation model to occupational hazard comprehensive evaluation of six posts under a coal mine, and the occupational hazard degree was graded, the evaluation results are consistent with actual situation. The results show that dust and noise is most obvious among the coal mine occupational hazard factors. Excavation face support workers are most affected, secondly, heading machine drivers, coal cutter drivers, coalface move support workers, the occupational hazard degree of these four types workers is II mild level. The occupational hazard degree of ventilation workers and safety inspection workers is I level. The evaluation model could evaluate underground coal mine objectively and accurately, and can be employed to the actual engineering.

  13. Engagement in occupation as an inquiring process

    DEFF Research Database (Denmark)

    Madsen, Jacob Østergaard; Josephsson, Staffan

    2017-01-01

    the situatedness of occupation from the perspective of how situation and occupation work together. We argue that this approach can provide a theoretical understanding of engagement in occupation as a natural inquiry process. Viewing occupation from this perspective, we suggest, reveals its transformative capacity......A number of existing contributions within occupational science have explored the situatedness of occupation by asking what. We identify this perspective as limiting understandings of the relationship of situation and occupation. Instead, we propose using John Dewey’s theory of inquiry to explore......, situating it in the doing of explorative actions, depending on contextual cues. The implications of the suggested situatedness of occupation are discussed, and the authors present ‘enacted situated inquiry’ as a way to further understandings of the relationship of occupation and situation, along...

  14. Hannah Arendt - Filosofia e Política

    Directory of Open Access Journals (Sweden)

    Eduardo Jardim de Moraes

    2007-12-01

    Full Text Available O artigo apresenta a visão de Hannah Arendt de três momentos em que se configura, na história da filosofia política, a relação entre filosofia e política.O primeiro é o contexto antigo, representado na obra de Platão, quando a filosofia é entendida como metafísica e o conceito central da política é o de autoridade.O segundo remete à moderna crise do conceito metafísico de verdade e do conceito político de autoridade.O terceiro refere-se à leitura de Arendt da obra de Kant e aponta para a relevância da sua teoria do juízo.

  15. Lo social desde la política

    Directory of Open Access Journals (Sweden)

    Darío Salinas Figueredo

    2000-01-01

    Full Text Available Sin desconocer las aproximaciones existentes sobre aspectos fundamentales de la problemática social en América Latina, por ejemplo la pobreza y la índole de política que de manera predominante se formula para encararla, la trayectoria argumental de este trabajo se encamina a mostrar la importancia de trabajar hacia el desarrollo de una perspectiva más amplia. Las referencias empíricas cotejadas no se refieren a hechos puntuales, sino a indicadores que pautan tendencias. Siendo los propósitos aquí reunidos de naturaleza comprensiva, se parte de la premisa según la cual escasamente se problematiza lo social y la propia política social, sus vínculos con la política general, el modelo de desarrollo y el tipo de democracia que la política predominante busca proyectar.

  16. Epidemiologia e políticas públicas

    OpenAIRE

    Barata,Rita Barradas

    2013-01-01

    Este ensaio trata das relações entre a epidemiologia e as políticas públicas, destacando inicialmente a posição da disciplina no campo da saúde coletiva, analisando os impactos de políticas públicas sobre o perfil epidemiológico e as contribuições da epidemiologia para a formulação, implementação e avaliação de políticas públicas de saúde. No primeiro tópico são discutidos os vínculos da disciplina com o campo da saúde coletiva, o modelo de determinantes sociais e de ação política formulados ...

  17. Occupational health programme for lead workers in battery plants

    Science.gov (United States)

    Lee, Byung-Kook

    The realization of problems resulting from the exposure to undue high lead levels of workers in lead-using industries, particularly in storage battery plants, has given rise to a new occupational health service, the so-called type specific (harmful agent specific) group occupational health. In 1988, the Korean Ministry of Labor designated the Institute of Industrial Medicine, Soonchunhyang University, as an authorized organization to take care of lead workers in lead industries. The following occupational health services are provided by the Institute: (i) physical health examination; (ii) biological monitoring with zinc protoporphyrin, urine δ-aminolevulinic acid and blood lead; (iii) respiratory protection with maintenance-free respirators; (iv) measurement of the environmental condition of workplaces; (v) health education. A three-year occupational health programme for lead workers has contributed to improvements in the working conditions of lead industries, particularly in large-scale battery plants, and has decreased the unnecessary high lead burden of workers through on-going medical surveillance with biological monitoring and health education schemes. The strong commitment of both employers and the government to improve the working conditions of lead industries, together with the full cooperation of lead workers, has served to reduce the high lead burdens of lead workers. This decreases the number of lead-poisoning cases and provides more comfortable workplaces, particularly in battery plants.

  18. Occupational asthma in maritime environments

    DEFF Research Database (Denmark)

    Lucas, David; Loddé, Brice; Jepsen, Jørgen Riis

    2016-01-01

    In 2006 we published our first review based on the available literature on occupational asthma in maritime environments in the “International Maritime Health” journal. Since then, we have obtained a great deal of new knowledge on asthma in seafood workers and fishermen and on the impact...... of exposures from sulphites preservatives, container fumigants etc. in maritime workers. This review aims to provide an update of the current knowledge base about occupational asthma in a maritime context and to provide recommendations regarding medical surveillance of workers at risk....

  19. The Healing Nature of Occupation

    Directory of Open Access Journals (Sweden)

    Jennifer Fortuna

    2017-03-01

    Full Text Available Moses Hamilton, an artist based in Hawaii, provided the cover art for the Spring 2017 edition of The Open Journal of Occupational Therapy (OJOT. “Pali Kai” is a 11”x14” painting made from acrylic on canvas. When a tragic car accident left Hamilton paralyzed from the chest down, mouth painting provided an outlet for selfexpression and stress relief. Participation in a meaningful occupation helped Hamilton find his path in life. With their colorful impressionist-style, Hamilton’s paintings have brought happiness to people all over the world.

  20. Politeia: la política

    Directory of Open Access Journals (Sweden)

    Manuel Briceño Jáuregui

    1982-07-01

    Full Text Available Se trata solamente de La Política, una versión reciente que está en proceso de publicación. Aristóteles sostiene que la felicidad completa del individuo no es posible sino en la sociedad, especialmente en la polis, que es la sociedad por excelencia. El individuo no puede por sí mismo satisfacer sus necesidad es materiales ni alcanzar la virtud. Para mostrarlo examina primero los diferentes grupos humanos, a partir de la familia; analiza luego las diversas politeias (constituciones de entonces, algunas de las cuales condena. Distingue siguiendo a su maestro Platón tres politeias (formas de gobierno legítimas monarquía, aristocracia, democracia, que dan lugar a su vez a tres desviaciones de las mismas tiranía , oligarquía y demagogia respectivamente. Termina señalando la importancia humana y cívica de la educación.

  1. Improving occupational safety and health by integration into product development

    DEFF Research Database (Denmark)

    Broberg, Ole

    1996-01-01

    A cross-sectional case study was performed in a large company producing electro-mechanical products for industrial application. The objectives were: (i) to study the product development process and the role of key actors', (ii) to identify current practice on integrating occupational safety and h...... and studies of documents. A questionnaire regarding product development tasks and occupational safety and health were distributed to 30 design and production engineers. A total of 27 completed the questionnaire corresponding to a response rate of 90 per cent.......A cross-sectional case study was performed in a large company producing electro-mechanical products for industrial application. The objectives were: (i) to study the product development process and the role of key actors', (ii) to identify current practice on integrating occupational safety...... and health into the development process, especially the efforts and attitudes of design and production engineers', and (iii) to identify key actors'reflections on how to improve this integration. The study was based on qualitative as well as quantitative methods including interviews, questionnaires...

  2. Hearing loss in the elderly: History of occupational noise exposure.

    Science.gov (United States)

    Meneses-Barriviera, Caroline Luiz; Melo, Juliana Jandre; Marchiori, Luciana Lozza de Moraes

    2013-04-01

     Noise exposure is one of the most common health risk factors, and workers are exposed to sound pressure levels capable of producing hearing loss.  To assess the prevalence of hearing loss in the elderly and its possible association with a history of occupational noise exposure and with sex.  A prospective study in subjects aged over 60 years. The subjects underwent anamnesis and audiological assessment. The Mann-Whitney test and multiple logistic regression, with 95% confidence interval and p hearing I (500, 1000, and 2000 Hz p = 0.8318) and the mean hearing II (3000, 4000, and 6000 Hz; p occupational noise exposure, we obtained the medium hearing I (p = 0.9542) and the mean hearing II (p = 0.0007).  There was a statistically significant association between hearing loss at high frequencies and the risk factors being male and occupational noise exposure.

  3. Occupational Asthma after Withdrawal from the Occupational Allergen Exposure

    Czech Academy of Sciences Publication Activity Database

    Klusáčková, P.; Pelclová, D.; Lebedová, J.; Marečková, H.; Brabec, Marek

    2006-01-01

    Roč. 44, č. 4 (2006), s. 629-638 ISSN 0019-8366 Source of funding: V - iné verejné zdroje Keywords : occupational asthma * allergen exposure withdrawal Subject RIV: BB - Applied Statistics, Operational Research Impact factor: 0.911, year: 2006 http://www.jniosh.go.jp/en/indu_hel/pdf/indhealth_44_4_629.pdf

  4. Civilian law: from occupational medicine to occupational event.

    Science.gov (United States)

    Mpotos, N; Watelet, J B

    Civilian law:from occupational medicine to occupational event. Despite the growing importance of objective measurements, the health effects of many occupational risk factors are currently not fully quantified. Occupational noise, as a widespread risk factor, is illustrative in this regard; there is a strong body of evidence linking it to an important health outcome (hearing loss), but it is less decisively associated with others (such as psychological disorders). It is also distinct from environmental noise, and therefore falls under the responsibility of employers as well as individuals. Noise-induced hearing loss (NIHL) is, at present, incurable and irreversible. However, it is preventable, if effective and global hearing conservation programmes can be implemented. These programmes should not be isolated efforts, but should be integrated into the overall hazard prevention and control programme of the workplace. Belgian law encompasses a set of provisions for prevention and the protection of the health and safety of workers within the workplace, including aspects pertaining to the hygiene of the workplace and psychosocial aspects at work (stress, violence, bullying and sexual harassment, among others). In principle, combating environmental noise is fully addressed in this country. However, other levels of policy-making also play an important role in this regard. For example, the federal government is in charge of product standards, and therefore also of noise emission standards for products. The interpretation and enforcement of Belgian legislation on well-being at work converts European directives and international agreements on well-being at work into Belgian law.

  5. On the Relationship Between First Occupation and Current Occupational Status

    Science.gov (United States)

    Beck, E. M.; Madans, J. H.

    1974-01-01

    Three alternative models are presented to represent the decreased importance of the status of first job on current occupational status overtime; there is evidence that the effects of first job erode with time. Models not explicitly incorporating labor force experience may suffer a serious specification error. (Author/AJ)

  6. [Prevention of HIV transmission (vertical, occupational and non-occupational)].

    Science.gov (United States)

    Azkune, Harkaitz; Ibarguren, Maialen; Camino, Xabier; Iribarren, José Antonio

    2011-10-01

    In these almost thirty years since the epidemic of HIV infection strategies have been developed to decrease the transmission risk when a non-infected person comes into contact with HIV. One of the key landmarks was the use zidovudine was shown to reduce the risk of HIV infection by vertical transmission from 25% to 8% when given from the second trimester of pregnancy, during partum and for several weeks in the newborn. These strategies have been subsequently perfected until achieving vertical transmission rates less than 1%. Almost at the same time, strategies have been developed in an attempt to reduce the risk of transmission of infection after occupational accidents and, in the last few years prophylaxis after non-occupational exposure has been a field of particular concern. Even in this past year several experiments on pre-exposure prophylaxis have been published, which are generating an intense debate on is applicability. In this article, we analyse the state of the art in the prevention of vertical transmission and occupational and non-occupational prophylaxis, from a perspective of applying this in the developed world. We also review the published data on pre-exposure prophylaxis. Copyright © 2011 Elsevier España, S.L. All rights reserved.

  7. Política y Geometría

    Directory of Open Access Journals (Sweden)

    Isabel Lillo Villalobos

    2011-04-01

    Full Text Available En este trabajo se aplican conceptos matemáticos al planteamiento deun problema de competición política. Se desarrolla y se implementaademás un método que usa herramientas relacionadas con la geometríacomputacional para la resolución de dicho problema, probándose dicho método en un ejemplo basado en la política española.

  8. Oposición política y juicio del gobierno en las Cortes de 1592-98

    Directory of Open Access Journals (Sweden)

    I. A. A. THOMPSON

    2009-12-01

    Full Text Available RESUMEN: Las Cortes de Castilla de 1592-98 fueron con mucho las más largas del reinado de Felipe II, y las más dificultosas. Su propia duración hacía deseable y, a la vez, facilitaba un esfuerzo extraordinario por parte del gobierno para influir en la actuación de la asamblea. Pero, asimismo, posibilitaba la formación de una oposición organizada con un proyecto político coherente. El análisis detallado de las pautas de voto de los procuradores permite descubrir la existencia de determinadas agrupaciones políticas dentro de las Cortes y poner de manifiesto las bases ideológicas de la política opositora, así como los intereses, tanto en la corte como en las ciudades, que reflejaba en el crespúsculo del gobierno de Felipe II.ABSTRACT: The Cortes of 1592-98 were by far the longest and most difficult parliament of Philip II's reign. That very length both called for and facilitated an unparalleled effort at management by ministers of the Crown. It also made possible the formation within the assembly of an organised opposition with a coherent political programme. The close analysis of the voting behaviour of the proctors permits the reconstruction of definable political groupings within the Cortes and reveals the ideological bases of an oppositional position, as well as pointing to the political interests in the court and in the country which lay behind it as Philip II's government limped to its end.

  9. A questão da continuidade da política macroeconômica entre o governo Cardoso e Lula (1995-2006

    Directory of Open Access Journals (Sweden)

    José Marcos Nayme Novelli

    2010-06-01

    Full Text Available O objetivo do artigo é compreender a continuidade da política macroeconômica entre o governo Cardoso e o governo Lula. O artigo organiza-se em três seções. Na primeira, descreve-se sucintamente a política macroeconômica dos governos Cardoso e Lula. Na segunda, apresenta-se e discute-se o debate da literatura especializada a respeito da hipótese da continuidade da política macroeconômica entre os dois governos. Na terceira seção, é feito um mapeamento dos dirigentes estatais, em que ressaltamos certos aspectos que contribuíram para tal continuidade entre os dois governos. Sem desconsiderar a ação dos beneficiários últimos dos resultados de tal política, identificamos três fatores para explicar a manutenção da política macroeconômica: i a própria estrutura do capitalismo brasileiro e sua inserção na economia mundial; ii a força das idéias ortodoxas difundidas pela mídia e dominantes na equipe econômica (Ministério da Fazenda e Banco Central do Brasil, que foi recrutada no mesmo "campo"; iii a aceitação das "regras do jogo" da democracia pelo Partido dos Trabalhadores (PT.

  10. Cultura política y partidos en Jalisco

    Directory of Open Access Journals (Sweden)

    Carlos Silva Moreno

    2000-01-01

    Full Text Available El presente trabajo es un intento de análisis y reflexión sobre la cultura política de uno de los componentes de todo sistema político que se precie de ser democrático (al menos formalmente: los partidos políticos. Se estudia la cultura política de los partidos políticos en Jalisco a partir del análisis de las representaciones y valores que los partidos políticos tienen sobre la democracia interna, para después contrastarlas con algunas prácticas referentes al liderazgo, dirección y formas de competencia. Debido a que las dimensiones de la democracia son muy amplias y variadas, nos centramos en dos indicadores: la forma en que se da la competencia por los cargos de dirección interna y el carácter de la dirección y el liderazgo.

  11. Mitochondrial DNA replication: a PrimPol perspective

    Science.gov (United States)

    Bailey, Laura J.

    2017-01-01

    PrimPol, (primase–polymerase), the most recently identified eukaryotic polymerase, has roles in both nuclear and mitochondrial DNA maintenance. PrimPol is capable of acting as a DNA polymerase, with the ability to extend primers and also bypass a variety of oxidative and photolesions. In addition, PrimPol also functions as a primase, catalysing the preferential formation of DNA primers in a zinc finger-dependent manner. Although PrimPol's catalytic activities have been uncovered in vitro, we still know little about how and why it is targeted to the mitochondrion and what its key roles are in the maintenance of this multicopy DNA molecule. Unlike nuclear DNA, the mammalian mitochondrial genome is circular and the organelle has many unique proteins essential for its maintenance, presenting a differing environment within which PrimPol must function. Here, we discuss what is currently known about the mechanisms of DNA replication in the mitochondrion, the proteins that carry out these processes and how PrimPol is likely to be involved in assisting this vital cellular process. PMID:28408491

  12. Retrospectiva de la política universitaria en Venezuela

    Directory of Open Access Journals (Sweden)

    Pedro Rodríguez Rojas

    2017-07-01

    Full Text Available El propósito de este artículo es hacer una breve revisión histórica de la política universitaria en Venezuela. La política universitaria en Venezuela tiene como antecedente la Universidad Colonial, pero surge más concretamente a partir de la reforma de 1827. Las universidades son un ente fundamentalmente político. Las universidades no son solamente espacios para el adiestramiento y formación de los profesionales que requiere la nación. Las universidades reflejan a la sociedad a la que pertenecen. Cuando se refiere a la política universitaria venezolana estamos haciendo referencia a las políticas de los respectivos estados y gobiernos en relación al papel que debe jugar las universidades en el desenvolvimiento del país. Pretendemos responder a las preguntas: ¿cómo ha sido la relación entre los gobiernos y las universidades?, ¿Ha existido una política universitaria en Venezuela?, ¿Cómo han evolucionado los principios de equidad, democracia y autonomía en las universidades?, ¿Quién manda en las universidades?¿Qué y quiénes investigan?, ¿Cómo y quién mide la cal

  13. Mentir en la vida política

    Directory of Open Access Journals (Sweden)

    Martínez de la Escalera, Ana María

    2005-06-01

    Full Text Available In this paper the act of lying is seen as a necessary component of the political discourse of the polis. Plato and Arendt are examined as the representatives of a line of thought in which the political realm needs the act of lying. The actual problematic of lying in politics is debated.

    El texto «Mentir en política» aborda el papel que la mentira ha jugado en el lenguaje de la política y el lugar problemático que la Filosofía política le ha otorgado. Se escogen dos autores, Platón y Arendt, para mostrar la necesidad de incluir el discurso mentiroso como un componente esencial de la vida política de la ciudad. En breve, se trata de analizar los límites que la ciudad impone al discurso de lo político y de la política.

  14. Herencia política y económica

    Directory of Open Access Journals (Sweden)

    Wesley C. Marshall

    2011-01-01

    Full Text Available El artículo busca resaltar la relevancia de la vida política de Hilferding en el actual contexto de la crisis financiera global y la probablemente alta radicalización de las posiciones políticas de los países dominantes como resultado de aquella. Como se argumenta, había un alto grado de coherencia entre el pensamiento económico de Hilferding y su actuación política. Justamente por el hecho de que el proyecto socialista alemán durante la Republica Weimar no logró sus objetivos, el pensamiento político y económico de su líder intelectual es altamente relevante en el escenario global actual, donde la crisis económica y descomposición social y política que la acompañen reclaman a los principales políticos del mundo un entendimiento económico más amplio y profundo para que las tragedias de Europa central de los años treinta y cuarenta del siglo XX no se reproduzcan.

  15. Broadening the occupational therapy toolkit: an executive functioning lens for occupational therapy with children and youth.

    Science.gov (United States)

    Cramm, Heidi; Krupa, Terry; Missiuna, Cheryl; Lysaght, Rosemary M; Parker, Kevin C H

    2013-01-01

    Attention to executive functioning (EF) and its effect on occupational performance is increasing in the occupational therapy literature. This study explored occupational therapists' perceptions of how EF is recognized and addressed within occupational therapy for children and youth. Inductive qualitative content analysis was used to analyze the in-depth interview data from 13 occupational therapists with a range of practice contexts and experience. EF should be explicitly considered during clinical reasoning. System and professional barriers create challenges to occupational therapists, constraining their ability to recognize, label, and address EF performance issues. Occupational therapists who have integrated EF into their practice perspective have acquired knowledge and skills through interprofessional collaborations, client interactions, and professional development opportunities. Occupational therapists working with children and youth need an occupational EF framework and practice resources if they are to integrate an EF lens to more broadly enable occupational performance. Copyright © 2013 by the American Occupational Therapy Association, Inc.

  16. Estudo Pré-Clínico de Stent com Polímero Biodegradável e Liberação Abluminal de Sirolimus

    Directory of Open Access Journals (Sweden)

    Celso Kiyochi Takimura

    2014-06-01

    Full Text Available Fundamento: Stents recobertos com polímeros bioabsorvíveis e fármacos apenas na face abluminal podem ser mais seguros que stents farmacológicos com polímeros permanentes. Objetivo: Relatar os resultados experimentais com o stent Inspiron(r, um stent recoberto com polímero bioabsorvível e com liberação de sirolimus apenas da face abluminal, recentemente aprovado para uso clínico. Métodos: Foram implantados 45 stents nas artérias coronárias de 15 porcos e, no 28° dia pós-implante, foram obtidos os resultados angiográficos, de ultrassonografia intracoronária e de histomorfologia. Cinco grupos foram avaliados: Grupo I (nove stents sem recobrimento; Grupo II (nove stents com polímero bioabsorvível nas faces luminal e abluminal; Grupo III (oito stents com polímero bioabsorvível na face abluminal; Grupo IV (nove stents com polímero bioabsorvível e sirolimus nas faces luminal e abluminal; e Grupo V (dez stents com polímero bioabsorvível e sirolimus na face abluminal exclusivamente. Resultados: Observamos, para os Grupos I, II, III, IV e V respectivamente: porcentual de estenose de 29 ± 20; 36 ± 14; 33 ± 19; 22 ± 13 e 26 ± 15 (p = 0,443; perda luminal tardia (em mm de 1,02 ± 0,60; 1,24 ± 0,48; 1,11 ± 0,54; 0,72 ± 0,44 e 0,78 ± 0,39 (p = 0,253; área neointimal (em mm2 de 2,60 ± 1,99; 2,74 ± 1,51; 2,74 ± 1,30; 1,30 ± 1,14 e 0,97 ± 0,84 (p = 0,001; Grupos IV e V versus Grupos I, II e III e porcentual de área neointimal de 35 ± 25; 38 ± 18; 39 ± 19; 19 ± 18 e 15 ± 12 (p = 0,001; Grupo IV e V versus Grupo I, II e III. Os escores de injúria e inflamação foram baixos e sem diferenças entre os grupos. Conclusão: O stent Inspiron(r foi seguro e inibiu significativamente a hiperplasia neointimal observada no 28° dia pós-implante em artérias coronárias porcinas.

  17. Towards inclusive occupational therapy: Introducing the CORE approach for inclusive and occupation-focused practice.

    Science.gov (United States)

    Pereira, Robert B

    2017-12-01

    Occupation is a human right and a social determinant of health. It is also taken for granted. Having access to, and participating in, occupation, is intricately linked to positive health and wellbeing. Despite theory and evidence to support the link between occupation, health and wellbeing, occupational therapists can struggle with applying an occupation focus in practice and knowing how to use occupational frameworks to enable occupation. The purpose of this paper is to introduce the Capabilities, Opportunities, Resources and Environments (CORE) approach for inclusive and occupation-focused practice. It provides occupational therapists with a means of operationalising occupational enablement and facilitating social inclusion. The CORE approach is introduced by linking its main ideas to Economist and Nobel Prize Laureate Amartya Sen's capabilities approach, as well as findings from the author's doctoral research into entrenched disadvantage and social inclusion. Practical questions guided by the CORE approach's acronym are given to explore how the approach can be utilised alongside other occupational models and frameworks to encourage strategies for effective enablement through occupation for social inclusion. As experts in enabling occupation, occupational therapists can use the CORE approach to design occupation-focused interventions and promote inclusive occupational therapy. © 2017 Occupational Therapy Australia.

  18. 8224 OCCUPATIONAL DIVERSIFICATION AMONG RURAL ...

    African Journals Online (AJOL)

    and stabilize their incomes which are determined by their portfolio of assets - social, human, financial, natural and physical capital [5]. Non-agricultural activities vary ... occupational adjustment, income-earning re-orientation, social identification and spatial relocation away from agricultural-based modes of livelihood [10].

  19. Occupational Neurotoxic Diseases in Taiwan

    Directory of Open Access Journals (Sweden)

    Chi-Hung Liu

    2012-12-01

    Full Text Available Occupational neurotoxic diseases have become increasingly common in Taiwan due to industrialization. Over the past 40 years, Taiwan has transformed from an agricultural society to an industrial society. The most common neurotoxic diseases also changed from organophosphate poisoning to heavy metal intoxication, and then to organic solvent and semiconductor agent poisoning. The nervous system is particularly vulnerable to toxic agents because of its high metabolic rate. Neurological manifestations may be transient or permanent, and may range from cognitive dysfunction, cerebellar ataxia, Parkinsonism, sensorimotor neuropathy and autonomic dysfunction to neuromuscular junction disorders. This study attempts to provide a review of the major outbreaks of occupational neurotoxins from 1968 to 2012. A total of 16 occupational neurotoxins, including organophosphates, toxic gases, heavy metals, organic solvents, and other toxic chemicals, were reviewed. Peer-reviewed articles related to the electrophysiology, neuroimaging, treatment and long-term follow up of these neurotoxic diseases were also obtained. The heavy metals involved consisted of lead, manganese, organic tin, mercury, arsenic, and thallium. The organic solvents included n-hexane, toluene, mixed solvents and carbon disulfide. Toxic gases such as carbon monoxide, and hydrogen sulfide were also included, along with toxic chemicals including polychlorinated biphenyls, tetramethylammonium hydroxide, organophosphates, and dimethylamine borane. In addition we attempted to correlate these events to the timeline of industrial development in Taiwan. By researching this topic, the hope is that it may help other developing countries to improve industrial hygiene and promote occupational safety and health care during the process of industrialization.

  20. Human capital formation from occupations

    DEFF Research Database (Denmark)

    de Pleijt, Alexandra M.; Weisdorf, Jacob L.

    2017-01-01

    We use HISCLASS to code the occupational titles of over 30,000 English male workers according to the skill content of their work. We then track the evolution of the sampled working skills across three centuries of English history, from 1550 to 1850. We observe a modest rise in the share of ‘high...

  1. OCCUPATIONAL HEALTH HAZARDS AMONG QUARRY ...

    African Journals Online (AJOL)

    Key Words: Occupational health hazards, Industrial pollution, Quarry industry, Sources of hazards, Preventive practices, Awareness ... The type of quarrying industry present in Ebonyi State ranges from manual stone crushing industry to small and medium ..... Lagos: Macmillan Printing Press. Ashley, M.N. (2004) Dustiness, ...

  2. Employee occupational stress in banking.

    Science.gov (United States)

    Michailidis, Maria; Georgiou, Yiota

    2005-01-01

    Occupational stress literature emphasizes the importance of assessment and management of work related stress. The recognition of the harmful physical and psychological effects of stress on both individuals and organizations is widely studied in many parts of the world. However, in other regions such research is only at the introductory stages. The present study examines occupational stress of employees in the banking sector. A sample of 60 bank employees at different organizational levels and educational backgrounds was used. Data collection utilized the Occupational Stress Indicator (OSI). Results of data analysis provided evidence that employees' educational levels affect the degree of stress they experience in various ways. Bank employees cannot afford the time to relax and "wind down" when they are faced with work variety, discrimination, favoritism, delegation and conflicting tasks. The study also shows the degree to which some employees tend to bring work-related problems home (and take family problems to work) depends on their educational background, the strength of the employees' family support, and the amount of time available for them to relax. Finally, the drinking habits (alcohol) of the employees were found to play a significant role in determining the levels of occupational stress.

  3. Travel Agent. Occupational Simulation Kit.

    Science.gov (United States)

    Peterson, Wayne

    This career exploration instructional booklet on the travel agent's occupation is one of several resulting from the rural southwestern Colorado CEPAC Project (Career Education Process of Attitude Change). Based on a job analysis and utilizing a programed instructional format, the following content is included: A brief description of what a travel…

  4. Copper (II)

    African Journals Online (AJOL)

    CLEMENT O BEWAJI

    ABSTRACT: A Schiff base was prepared from the reaction of 2 - amino - 3 – methylbutanoic acid and 2, 4 - pentanedione. The reaction of the prepared Schiff base with ethanolic solution of copper (II) chloride formed diaquo bis( N – 2 – amino – 3 - methylbutyl - 2, 4 - pentanedionato) copper (II) complex. The Schiff base is ...

  5. Grupos Políticos Romanos (150-133 a.C.

    Directory of Open Access Journals (Sweden)

    Enrique GARCÍA RIAZA

    2009-11-01

    Full Text Available RESUMEN: Este trabajo analiza el tejido político de la aristocracia romana en los años centrales del siglo II a.C, momento en el que los condicionantes socio-económicos derivados de la expansión mediterránea generan, a un tiempo, un aumento de las reivindicaciones de la plebe, y una importante acentuación de las rivalidades internas en el seno de la aristocracia. Con estas premisas, abordamos el estudio de los grupos de solidaridad política constituidos en torno a determinados individuos y familias. La significación de la figura de Escipión Emiliano no debe ocultar el papel de Mételo Macedónico, de los Calpurnios Pisones y, especialmente, de los Claudio-Fulvios, quienes ensayarán, de forma paralela a Emiliano, una nueva vía de protagonismo basada en la política social. ABSTRACT: This paper deals with the political organization of the Roman aristocracy during the central years of the Ilnd. Century b.C. The Roman conquest of the Mediterranean World, achieved by means of a considerable military effort, was responsible of the development in Italy of new social and economical factors. The growing popular claims and the acentuation of aristocratical competition are the main features of this trend. A prosopographical research makes it clear that some relevant political groups have been traditionaly hidden because of an excesive focus on Scipio Aemilianus. Thus, Metellus Macedonicus, the Calpurnii Pisones and, above all, the Claudii-Fulvii played a decisive paper in the context of political struggle, and some of their members even shared with Scipio an interest in pro-popular politics.

  6. The Danish Press during the German Occupation

    DEFF Research Database (Denmark)

    Roslyng-Jensen, Palle

    2010-01-01

    Censorship, self-censorship in Danish newspapers and Danish Radio during the German occupation of Denmark 1940-45......Censorship, self-censorship in Danish newspapers and Danish Radio during the German occupation of Denmark 1940-45...

  7. American Association of Occupational Health Nurses

    Science.gov (United States)

    ... Online Store Workplace Health & Safety Journal Awards & Recognition Occupational Health Nurses Week Member Discounts Monthly Newsletter Foundation About ... effective January 1, 2018. The American Association of Occupational Health Nurses, Inc. is the primary association for the ...

  8. National Institute for Occupational Safety and Health

    Science.gov (United States)

    ... Submit Search The CDC The National Institute for Occupational Safety and Health (NIOSH) Note: Javascript is disabled or is not ... and Events NIOSH Contact Information Related Federal Agencies Occupational Safety and Health Administration Mine Safety and Health Administration Follow NIOSH ...

  9. Physical Therapy and Occupational Therapy in Progeria

    Science.gov (United States)

    Physical Therapy and Occupational Therapy in Progeria Information for Families and Caretakers from The Progeria Research Foundation ... Inc. All rights reserved. Page 2 of 5 Physical and Occupational Therapy in Progeria Hutchinson-Gilford Progeria ...

  10. Research priorities in mental health occupational therapy: A study of clinician perspectives.

    Science.gov (United States)

    Hitch, Danielle; Lhuede, Kate

    2015-10-01

    The evidence to support mental health occupational therapy has proliferated in the early years of this century, but this growth has tended to be organic rather than targeted. Previous efforts to identify research priorities in this area of practice are either out dated, or encompass discrete areas of practice. The aim of this study was to identify priority areas for research in mental health occupational therapy from clinician's perspectives. A Policy Delphi method was used to enable occupational therapists to define and differentiate their perspectives on research priorities. Forty-two occupational therapists took part in the first two rounds of this method, with 69% (n = 29) going on to complete the third and final round of data collection. A Likert scale was used to rate the importance of each priority, and descriptive quantitative analysis undertaken to identify those most consistently identified as being highly important. Four research priorities were identified as being highly important in this study: (i) working in an occupationally focussed way; (ii) consumer experience of therapy groups; (iii) identifying factors which increase consumer engagement in occupation; and (iv) engaging patients on the inpatient unit in meaningful and positive occupation. Two of the priority areas are already the subject of substantial evidence bases, but there has been far less research into consumer experiences of groups and occupational engagement in acute settings. Collaboration between research teams and greater consumer inclusion are recommended for the future. This study provides an updated indication of research priorities for mental health occupational therapy in Australia. © 2015 Occupational Therapy Australia.

  11. Occupational rhinitis due to steel welding fumes.

    Science.gov (United States)

    Castano, Roberto; Suarthana, Eva

    2014-12-01

    Exposure to welding fumes is a recognized respiratory hazard. Occupational asthma but not occupational rhinitis has been documented in workers exposed to steel welding fumes. We report a 26-year-old male with work-related rhinitis symptoms as well as lower airways symptoms suggestive of occupational asthma and metal fume fever associated with exposure to steel welding fumes. The diagnosis of occupational rhinitis was confirmed by specific inhalation challenge. © 2014 Wiley Periodicals, Inc.

  12. Occupational skin cancer may be underreported

    DEFF Research Database (Denmark)

    Carøe, Tanja Korfitsen; Ebbehøj, Niels Erik; Wulf, Hans Christian

    2013-01-01

    Skin cancer may, in some cases, be caused by occupational exposures. The aim of this study was to investigate the prevalence of and exposures leading to occupationally induced skin cancers in Denmark during a ten-year period.......Skin cancer may, in some cases, be caused by occupational exposures. The aim of this study was to investigate the prevalence of and exposures leading to occupationally induced skin cancers in Denmark during a ten-year period....

  13. Tyrosine phosphorylation of RNA polymerase II CTD is associated with antisense promoter transcription and active enhancers in mammalian cells

    Science.gov (United States)

    Descostes, Nicolas; Heidemann, Martin; Spinelli, Lionel; Schüller, Roland; Maqbool, Muhammad Ahmad; Fenouil, Romain; Koch, Frederic; Innocenti, Charlène; Gut, Marta; Gut, Ivo; Eick, Dirk; Andrau, Jean-Christophe

    2014-01-01

    In mammals, the carboxy-terminal domain (CTD) of RNA polymerase (Pol) II consists of 52 conserved heptapeptide repeats containing the consensus sequence Tyr1-Ser2-Pro3-Thr4-Ser5-Pro6-Ser7. Post-translational modifications of the CTD coordinate the transcription cycle and various steps of mRNA maturation. Here we describe Tyr1 phosphorylation (Tyr1P) as a hallmark of promoter (5′ associated) Pol II in mammalian cells, in contrast to what was described in yeast. Tyr1P is predominantly found in antisense orientation at promoters but is also specifically enriched at active enhancers. Mutation of Tyr1 to phenylalanine (Y1F) prevents the formation of the hyper-phosphorylated Pol IIO form, induces degradation of Pol II to the truncated Pol IIB form, and results in a lethal phenotype. Our results suggest that Tyr1P has evolved specialized and essential functions in higher eukaryotes associated with antisense promoter and enhancer transcription, and Pol II stability. DOI: http://dx.doi.org/10.7554/eLife.02105.001 PMID:24842994

  14. Communications-Related Occupations. Reprinted from the Occupational Outlook Handbook, 1978-79 Edition.

    Science.gov (United States)

    Bureau of Labor Statistics (DOL), Washington, DC.

    Focusing on communications-related occupations, this document is one in a series of forty-one reprints from the Occupational Outlook Handbook providing current information and employment projections for individual occupations and industries through 1985. The specific occupations covered in this document include advertising workers, interpreters,…

  15. 75 FR 5333 - Safety and Occupational Health Study Section (SOHSS), National Institute for Occupational Safety...

    Science.gov (United States)

    2010-02-02

    ... Occupational Health Study Section (SOHSS), National Institute for Occupational Safety and Health (NIOSH) In... Section 10(d) Public Law 92-463. Purpose: The Safety and Occupational Health Study Section will review... and funding cycles pertaining to research issues in occupational safety and health, and allied areas...

  16. 78 FR 56235 - Safety and Occupational Health Study Section (SOHSS), National Institute for Occupational Safety...

    Science.gov (United States)

    2013-09-12

    ... Occupational Health Study Section (SOHSS), National Institute for Occupational Safety and Health (NIOSH or... Occupational Health Study Section will review, discuss, and evaluate grant application(s) received in response... occupational safety and health, and allied areas. It is the intent of NIOSH to support broad-based research...

  17. 78 FR 24751 - Safety and Occupational Health Study Section (SOHSS), National Institute for Occupational Safety...

    Science.gov (United States)

    2013-04-26

    ... Occupational Health Study Section (SOHSS), National Institute for Occupational Safety and Health (NIOSH or... and Occupational Health Study Section will review, discuss, and evaluate grant application(s) received... issues in occupational safety and health, and allied areas. It is the intent of NIOSH to support broad...

  18. 76 FR 18220 - Safety and Occupational Health Study Section (SOHSS), National Institute for Occupational Safety...

    Science.gov (United States)

    2011-04-01

    ... Occupational Health Study Section (SOHSS), National Institute for Occupational Safety and Health (NIOSH) In... Services Office, CDC, pursuant to Public Law 92-463. Purpose: The Safety and Occupational Health Study... standard grants review and funding cycles pertaining to research issues in occupational safety and health...

  19. 76 FR 3908 - Safety and Occupational Health Study Section (SOHSS); National Institute for Occupational Safety...

    Science.gov (United States)

    2011-01-21

    ... Occupational Health Study Section (SOHSS); National Institute for Occupational Safety and Health (NIOSH...: (703) 684-5900, Fax: (703) 684-1403. Purpose: The Safety and Occupational Health Study Section will... grants review and funding cycles pertaining to research issues in occupational safety and health, and...

  20. 77 FR 75633 - Safety and Occupational Health Study Section (SOHSS), National Institute for Occupational Safety...

    Science.gov (United States)

    2012-12-21

    ... Occupational Health Study Section (SOHSS), National Institute for Occupational Safety and Health (NIOSH) In... Public Law 92-463. Purpose: The Safety and Occupational Health Study Section will review, discuss, and... cycles pertaining to research issues in occupational safety and health, and allied areas. It is the...

  1. 77 FR 4048 - Safety and Occupational Health Study Section (SOHSS), National Institute for Occupational Safety...

    Science.gov (United States)

    2012-01-26

    ... Occupational Health Study Section (SOHSS), National Institute for Occupational Safety and Health, (NIOSH) In... the magnitude of the aggregate health burden associated with occupational injuries and illnesses, as... occupational safety and health services, and the prevention of work-related injury and illness. It is...

  2. 77 FR 27776 - Safety and Occupational Health Study Section (SOHSS), National Institute for Occupational Safety...

    Science.gov (United States)

    2012-05-11

    ... Occupational Health Study Section (SOHSS), National Institute for Occupational Safety and Health (NIOSH) In... Services Office, CDC, pursuant to Public Law 92-463. Purpose: The Safety and Occupational Health Study... standard grants review and funding cycles pertaining to research issues in occupational safety and health...

  3. 78 FR 75922 - Safety and Occupational Health Study Section (SOHSS), National Institute for Occupational Safety...

    Science.gov (United States)

    2013-12-13

    ... Occupational Health Study Section (SOHSS), National Institute for Occupational Safety and Health (NIOSH or... Occupational Health Study Section will review, discuss, and evaluate grant application(s) received in response... occupational safety and health, and allied areas. It is the intent of NIOSH to support broad-based research...

  4. 75 FR 56549 - National Institute for Occupational Safety and Health (NIOSH), Safety and Occupational Health...

    Science.gov (United States)

    2010-09-16

    ... Institute for Occupational Safety and Health (NIOSH), Safety and Occupational Health Study Section (SOHSS...-1403. Purpose: The Safety and Occupational Health Study Section will review, discuss, and evaluate... pertaining to research issues in occupational safety and health, and allied areas. It is the intent of NIOSH...

  5. 76 FR 52330 - Safety and Occupational Health Study Section (SOHSS), National Institute for Occupational Safety...

    Science.gov (United States)

    2011-08-22

    ... Occupational Health Study Section (SOHSS), National Institute for Occupational Safety and Health (NIOSH) In... the magnitude of the aggregate health burden associated with occupational injuries and illnesses, as... occupational safety and health services, and the prevention of work-related injury and illness. It is...

  6. 77 FR 51810 - Safety and Occupational Health Study Section (SOHSS), National Institute for Occupational Safety...

    Science.gov (United States)

    2012-08-27

    ... Occupational Health Study Section (SOHSS), National Institute for Occupational Safety and Health (NIOSH) In... the magnitude of the aggregate health burden associated with occupational injuries and illnesses, as... occupational safety and health services, and the prevention of work-related injury and illness. It is...

  7. 75 FR 26266 - Safety and Occupational Health Study Section (SOHSS), National Institute for Occupational Safety...

    Science.gov (United States)

    2010-05-11

    ... Occupational Health Study Section (SOHSS), National Institute for Occupational Safety and Health (NIOSH) In...) Public Law 92-463. Purpose: The Safety and Occupational Health Study Section will review, discuss, and... cycles pertaining to research issues in occupational safety and health, and allied areas. It is the...

  8. Sales Occupations. Reprinted from the Occupational Outlook Handbook, 1978-79 Edition.

    Science.gov (United States)

    Bureau of Labor Statistics (DOL), Washington, DC.

    Focusing on sales occupations, this document is one in a series of forty-one reprints from the Occupational Outlook Handbook providing current information and employment projections for individual occupations and industries through 1985. The specific occupations covered in this document include automobile sales workers, buyers, insurance…

  9. The U-Shapes of Occupational Mobility

    DEFF Research Database (Denmark)

    Groes, Fane Naja; Kircher, Philipp; Manovskii, Iourii

    2015-01-01

    Using administrative panel data on the entire Danish population we document a new set of facts characterizing occupational mobility. For most occupations, mobility is U-shaped and directional: not only low but also high wage earners within an occupation have a particularly large probability...

  10. The U-Shapes of Occupational Mobility

    DEFF Research Database (Denmark)

    Groes, Fane; Kircher, Philipp; Manovskii, Iourii

    Using administrative panel data on the entire Danish population we document a new set of facts characterizing occupational mobility. For most occupations, mobility is U-shaped and directional: both low and high wage earners within an occupation have a particularly large probability of leaving...

  11. Occupational therapists in the Colombian penitentiary system

    Directory of Open Access Journals (Sweden)

    Angélica María Garzón-Sarmiento

    2017-01-01

    Conclusions: Occupational therapy should be strengthened in relation to the justice sector, and occupation should be recognized as a fundamental axis in re-socializing processes. Sectorial paths and related normative contents make employment visible as a strategy and indicator of changes in a population that, after transgressing the legal norms, can contribute to society through occupational and productive potential.

  12. Occupational health services in PR China

    International Nuclear Information System (INIS)

    Liang Youxin; Xiang Quanyong

    2004-01-01

    In China, the origin of occupational health started in the mid 1950s soon after the founding of the People's Republic of China. However, more complete concept and practice of occupational health was defined after the early 1980s, when China started her full-scale drive for economic reform and policy of openness. The integrity intends to cover occupational health, occupational medicine, industrial toxicology, industrial hygiene, occupational ergonomics, and occupational psychology as theoretical and practical components of occupational health. As a result, occupational health in China has undergone many changes and has improved over the past decades. These changes and improvements came about, most likely due to a new scheme, where a holistic approach of the recognition, regulation, and provision of occupational health services in a wider coverage is gradually formed and brought into effect. This presentation provides the current status of occupational health and safety problems, the latest legislative to occupational health and safety, and a general scenario of the organizational structure and function of occupational health services in China. It attempts to share with participants both our experience and lessons learned towards creating a more open and effective channel of ideas and information sharing

  13. The Evaluation of Occupational Social Work.

    Science.gov (United States)

    Googins, Bradley; Godfrey, Joline

    1985-01-01

    The evolution of occupational social work from its beginnings in welfare capitalism, through the human relations movement in the 1930s and 1940s, and into the occupational alcoholism programs and employee assistance programs of the last decade is surveyed. A broad definition of occupational social work is offered. (Author)

  14. protecting miners against occupational injuries and diseases

    African Journals Online (AJOL)

    user

    Against this background, safety and health at work lie at the heart of the system of social security. The occupational health and safety system plays a crucial role in protecting employees against occupational injuries and diseases in their workplace. In fact, the occupational health and safety system has far-reaching ...

  15. An interdisciplinary approach to occupational respiratory disorders

    NARCIS (Netherlands)

    van Rooy, G.B.G.J.

    2010-01-01

    The World Health Organization estimates that worldwide about 50 million new cases of occupational respiratory diseases emerge every year. Without preventative action, the burden of occupational diseases is expected to increase. In this thesis an alternative approach to deliver occupational health

  16. Zagazig Journal of Occupational Health and Safety

    African Journals Online (AJOL)

    Zagazig Journal of Occupational Health and Safety is aimed at physicians and researchers in the wide-ranging discipline of occupational and environmental health and safety. The field is devoted to the diagnosis, prevention, management and scientific analysis of occupational , environmental and safety health problems; ...

  17. Assessment of occupational injuries in Tendaho Agricultural ...

    African Journals Online (AJOL)

    ... to the prevailing occupational injuries. Conclusion: Multiple factors related to the work organization and employee's behavior increased the risk of occupational injuries. Continued on the job training, sustained work place inspections and proving occupational health and safety services should get emphasis in work places.

  18. Occupations, Role Characteristics, and Intergenerational Transmission.

    Science.gov (United States)

    Spenner, Kenneth I.

    1981-01-01

    Analysis of correlations in role relationships involving parent occupation and child's career choice and occupational aspiration were made to determine which characteristics of occupations play a part in intergenerational role transmission. Requirements and rewards were found to be the salient features. (Author/SK)

  19. Occupant modeling in the aerospace environment

    NARCIS (Netherlands)

    Yaklin, P.; Lim, T.; Marshall, R.

    1999-01-01

    Dynamic testing and occupant protection standards are a reality in the aerospace industry. Methods to model these situations are evolving. A method of modeling an occupant on a crew seat, in a drop test is presented. This method combines a rigid body occupant model with a finite element model of the

  20. Dissonance Reduction Through Shifting Occupational Involvement.

    Science.gov (United States)

    Washburne, Chandler

    This article attempts to demonstrate that an individual's occupational goals become adjusted to the position he is in---blocked goals tend to become of less interest and available goals are of increased interest, which tends to decrease dissonance. The author's hypothesis is that middle class occupational status occupants over a period of time…

  1. Women's Occupational Mobility After Work Interruption

    Directory of Open Access Journals (Sweden)

    Megumi Omori

    2006-04-01

    Full Text Available The basic tenents human capital theory suggest that women who leave occupations whith high atrophy rates will be those most likely to experience downward occupational mobility upon labor force renentry. The theory is confirmed. However, the impact on occupational mobility of an actual childbirth may opeerate indirectly through the length of time a woman is out of the labor force.

  2. Women's Occupational Mobility After Work Interruption

    OpenAIRE

    Megumi Omori; Shelley A. Smith

    2006-01-01

    The basic tenents human capital theory suggest that women who leave occupations whith high atrophy rates will be those most likely to experience downward occupational mobility upon labor force renentry. The theory is confirmed. However, the impact on occupational mobility of an actual childbirth may opeerate indirectly through the length of time a woman is out of the labor force.

  3. Occupations Classified by Their Age Structure

    Science.gov (United States)

    Smith, John M.

    1975-01-01

    An analysis of occupational age structures for males has pragmatic implications for vocational advice and decisions (particularly for older workers), personnel and manpower planning, and experimental research. (A 5-page appendix lists occupational age ratios for 2( categories of occupations based on 1961 census data.) (Author/AG)

  4. Exploring occupational therapy graduates' conceptualisations of ...

    African Journals Online (AJOL)

    Background. The concept of occupational justice was derived from a social justice perspective in response to a renewed commitment by the occupational therapy profession to address the occupational needs of individuals, groups and communities who experience social injustice. Accordingly, it is acknowledged that ...

  5. An Analysis of the Automobile Sales Occupation.

    Science.gov (United States)

    Bohac, Robert D.; Vernon, Robert C.

    The general purpose of the occupational analysis is to provide workable, basic information dealing with the many and varied duties performed in the auto sales occupation. The analysis follows the salesperson through the essential everyday performance of the tasks in the occupation. The duties involve the process of obtaining the prospects and…

  6. O neopragmatismo de Richard Rorty e a reflexão política contemporânea

    Directory of Open Access Journals (Sweden)

    Sérgio Eduardo Ferraz

    2014-03-01

    Full Text Available Este artigo examina o pensamento filosófico de Richard Rorty e, em particular, sua dimensão política, delineando seu tratamento original e crítico de temas centrais à teoria política contemporânea. O objetivo do texto é triplo: chamar a atenção para a fertilidade das ideias de um autor ainda pouco lido no Brasil (i, assinalar as notáveis consequências corrosivas da abordagem rortyana para pressupostos e pretensões fundantes de importantes vertentes da teoria política (ii, e, numa ótica mais positiva, apontar o potencial inspirador dos escritos desse autor para a reflexão sobre novos modos de justificação da democracia (iii. Salientam-se também, nesse último caso, os limites impostos a esse tipo de empreitada político-intelectual. A abordagem empregada consiste em demarcar os contornos gerais do projeto filosófico do autor, seguindo-se uma apresentação dos tópicos mais propriamente políticos da obra de Rorty. Mais especificamente, o artigo explora a proposta rortyana de substituição da noção de verdade pela de justificação, assinalando-se suas consequências para pretensões de verdade, objetividade e universalismo, presentes em diversas linhas da teoria política. Nesse veio, o artigo discute as eventuais implicações relativistas das teses rortyanas, chegando-se, por essa rota, às ideias de contingência, imaginação e persuasão, núcleos conceituais vitais à reflexão em tela. Um breve contraste com posições de autores como Habermas e Rawls, caros ao próprio Rorty, é esboçado no propósito de tornar mais clara a especificidade da abordagem rortyana da política. Transitando, do modo assinalado, por esses tópicos, o texto resulta em um panorama sintético da perspectiva rortyana acerca do que vem a ser, contemporaneamente, uma "política democrática", liberta de "universalismos" e "objetividades", na qual ganham estatuto decisivo questões de justificação, tolerância e coexist

  7. Estado e planejamento: o plano de metas do governo de Santa Catarina (1961 – 1970 – PLAMEG i e ii – enquanto instrumento de política desenvolvimentista State and planning: ‘PLAMEG i’ and ‘PLAMEG ii’ as instruments to improve the development in state of Santa Catarina (Brazil during the years 1961 and 1970

    Directory of Open Access Journals (Sweden)

    Caio Lauth Gualberto

    2013-03-01

    Full Text Available Este texto refere-se a uma pesquisa predominantemente qualitativa, fruto de um estudo exploratório-descritivo acerca das experiências de planejamento econômico realizadas pelo governo estadual em Santa Catarina, elaboradas durante o período compreendido entre 1961 e 1970, durante as gestões de Celso Ramos e Ivo Silveira e que ficaram conhecidas como Plano de Metas do Governo - PLAMEG I e II. Com o propósito de superar pontos de estrangulamentos que limitavam a expansão do setor produtivo, o governo estadual investiu nas áreas de educação, transporte, energia, sistema de crédito e agricultura e os resultados alcançados nesse decênio se refletiram na expansão no número de salas de aulas, ginásios de esporte, qualificação de professores, tempo de estudo de alunos, implantação e reformas de rodovias, expansão da oferta de energia, criação de sistema de crédito estadual, aumento da oferta agrícola, integração de produtores rurais, entre outros. Os dados coletados revelam que ao fim desse período, Santa Catarina pode contar com melhores condições infraestruturais para participar do movimento de crescimento da economia nacional. Em consequência disso, os resultados da pesquisa de maneira geral apontam que os ideais defendidos pela corrente desenvolvimentista, ou seja, aquela que entende que o Estado é o agente responsável pela garantia da criação das condições favoráveis à expansão das atividades produtivas e, consequentemente, pelo avanço em relação aos indicadores de desenvolvimento, ficam fortalecidos.  This paper describe the result of a descriptive and exploratory study that refers to an predominantly qualitative research about the experiences of economic planning carried out by the government of Santa Catarina (Brazil during the period between 1961 and 1970 and which became known as PLAMEG I and PLAMEG II.  In order to overcome the limits to the expansion of the productive sector, the government has

  8. Raymond Aron ante el maquiavelismo político

    Directory of Open Access Journals (Sweden)

    Molina Cano, Jerónimo

    2008-08-01

    Full Text Available It is a simplification of Raymond Aron´s thought to consider him as a mere neo-liberal political thinker. The French sociologist, a well-known political realist, took part in the famous controversy about Machiavellianism that was Aron´s intellectual watershed from the Forties. Starting from that controversy the aim of the present paper is to inquire into his contribution to the so-called “moderate Machiavellianism”, whose Arcanum is that it is not always possible to choose the optimal means to face the right political action. Machiavellianism is not a merely scientific or epistemological question, but something that deeply determines all political actions.

    La presentación de Raymond Aron como un escritor político neoliberal constituye una simplificación de su pensamiento. El sociólogo francés, que pertenece a la tradición del realismo político, tuvo una destacada intervención en la famosa polémica sobre el maquiavelismo que marcó un punto de inflexión en su pensamiento. Este artículo examina su contribución a esa inagotable polémica intelectual desde los años 40 y constata, finalmente, su encuadramiento en el denominado “maquiavelismo moderado”, cuyo arcano político es que, en política, no siempre se pueden elegir los medios de la acción. El maquiavelismo no es, en este sentido, un asunto científico o epistemológico, sino que determina profundamente toda acción política.

  9. 77 FR 2340 - Occupational Information Development Advisory Panel

    Science.gov (United States)

    2012-01-17

    ..., forensic vocational assessment, and physical or occupational therapy; (c) occupational or physical... activities to create an occupational information system (OIS) tailored specifically for our disability... SOCIAL SECURITY ADMINISTRATION [Docket No. SSA-2012-0003] Occupational Information Development...

  10. 76 FR 2189 - Occupational Information Development Advisory Panel

    Science.gov (United States)

    2011-01-12

    ... occupational therapy; (c) occupational or physical rehabilitation medicine, psychiatry, or psychology; and (d... plans and activities to create an occupational information system (OIS) tailored specifically for SSA's... SOCIAL SECURITY ADMINISTRATION [Docket No. SSA-2011-0006] Occupational Information Development...

  11. Food system sustainability and vulnerability: food acquisition during the military occupation of Kuwait.

    Science.gov (United States)

    Alajmi, Fahhad; Somerset, Shawn M

    2015-11-01

    To document food acquisition experiences during Iraqi military occupation in Kuwait. Retrospective cross-sectional study. Urban areas in Kuwait during occupation. Those living in Kuwait during the period of occupation, and aged between 15 to 50 years at the time of occupation, recruited by snowball sampling. A total of 390 completed questionnaires (response rate 78%, 202 female and 188 male) were returned. During the occupation, food became increasingly difficult to acquire. Two food systems emerged: (i) an underground Kuwaiti network linked to foods recovered from local food cooperatives and (ii) a black market supplied by food imported through Iraq or stolen locally. Food shortages led to reductions in meal size and frequency. Some respondents (47·7%) reported not having sufficient income to purchase food and 22·1% had to sell capital items to purchase food. There was a significant increase (Pweight during the occupation. Although the Kuwaiti population fell by about 90 % and domestic food production increased during the 7-month occupation, the local population continued to rely heavily on imported food to meet population needs. The high prevalence of self-reported weight loss indicates the inadequacies of this food supply. High apparent food security in systems which significantly exceed the ecological carrying capacity of the local environment and rely on mass food importation remains vulnerable.

  12. Occupational health care return-to-work practices for workers with job burnout.

    Science.gov (United States)

    Kärkkäinen, Riitta; Saaranen, Terhi; Räsänen, Kimmo

    2018-02-23

    Occupational health care supports return to work in cases of burnout; however, there is little research on return-to-work practices. To describe occupational health care return-to-work practices for workers with burnout and to identify potential for the development of the practices. Open-ended interviews and essays were used to collect data from 25 occupational health care professionals. A qualitative content analysis method was used. Occupational health care was involved in the return-to-work support in the off-work, work re-entry and maintenance phases during the return-to-work process. However, occupational health care had no influence in the advancement phase. The key return-to-work actions were: (i) defining burnout, (ii) supporting disengagement from work, (iii) supporting recovery, (iv) determining the return-to-work goal, (v) supporting re-engagement with work, (vi) monitoring the job-person match, (vii) re-evaluating the return-to-work goal, (viii) supporting the maintenance of the achieved return-to-work goal, and, where appropriate, (ix) supporting an alternative return-to-work goal. There were varied return-to-work practices among the occupational health care centers evaluated. The occupational health care return-to-work practices for workers with burnout are described with recommendations to further develop common practice guidelines.

  13. An outstanding female figure in the history of occupational health: Ersilia Majno Bronzini.

    Science.gov (United States)

    Salerno, Silvana

    2010-01-01

    Starting with the obituary "Ersilia Majno Bronzini: an outstanding female figure in Occupational Health", probably written by Luigi Devoto and published in the journal La Medicina del Lavoro (1933), a reappraisal is made of Majno Bronzini's contribution to occupational health. Most references were collected from the archives of the journal Il Lavoro (1901), the archives of the association "Union of Women", the periodical founded by Majno Bronzini (1899) and other material. Majno Bronzini's selected published papers (1895, 1900, 1902) on the working conditions of women and child labour proposing a national occupational health law were found. The importance of a women's network for occupational health is also shown in Majno Bronzini's correspondence with Anna Celli Frantzel and Maria Montessori. In 1902 Angelo Celli officially congratulated Majno Bronzini's (and Anne Kuliscioff's) efforts to promulgate the first law on women and child labour during his speech before the Italian Parliament, published by II Lavoro. Majno Bronzini and Nina Rignano Sullam were the only two women participating in the First International Congress on Occupational Health in Milan (1906). The correspondence between Majno Bronzini and Devoto (1901-1933) and Devoto's formal acknowledgement of Majno Bronzini (1910) when inaugurating the new "Clinica del Lavoro" institute is well documented. Majno Bronzini dedicated a significant part of her life to occupational health, together with Anna Celli Frantzel and Maria Montessori along with many others. This research shows how important her contribution was to occupational health development.

  14. Orthoretroviral-like prototype foamy virus gag-pol expression is compatible with viral replication

    Directory of Open Access Journals (Sweden)

    Reh Juliane

    2011-08-01

    Full Text Available Abstract Background Foamy viruses (FVs unlike orthoretroviruses express Pol as a separate precursor protein and not as a Gag-Pol fusion protein. A unique packaging strategy, involving recognition of briding viral RNA by both Pol precursor and Gag as well as potential Gag-Pol protein interactions, ensures Pol particle encapsidation. Results Several Prototype FV (PFV Gag-Pol fusion protein constructs were generated to examine whether PFV replication is compatible with an orthoretroviral-like Pol expression. During their analysis, non-particle-associated secreted Pol precursor protein was discovered in extracellular wild type PFV particle preparations of different origin, copurifying in simple virion enrichment protocols. Different analysis methods suggest that extracellular wild type PFV particles contain predominantly mature p85PR-RT and p40IN Pol subunits. Characterization of various PFV Gag-Pol fusion constructs revealed that PFV Pol expression in an orthoretroviral manner is compatible with PFV replication as long as a proteolytic processing between Gag and Pol proteins is possible. PFV Gag-Pol translation by a HIV-1 like ribosomal frameshift signal resulted in production of replication-competent virions, although cell- and particle-associated Pol levels were reduced in comparison to wild type. In-frame fusion of PFV Gag and Pol ORFs led to increased cellular Pol levels, but particle incorporation was only marginally elevated. Unlike that reported for similar orthoretroviral constructs, a full-length in-frame PFV Gag-Pol fusion construct showed wildtype-like particle release and infectivity characteristics. In contrast, in-frame PFV Gag-Pol fusion with C-terminal Gag ORF truncations or non-removable Gag peptide addition to Pol displayed wildtype particle release, but reduced particle infectivity. PFV Gag-Pol precursor fusion proteins with inactivated protease were highly deficient in regular particle release, although coexpression of p71Gag

  15. User involvement in measuring service quality of local authority occupational therapy services: a new approach.

    NARCIS (Netherlands)

    Sixma, H.J.; Calnan, S.; Calnan, M.; Groenewegen, P.P.

    2001-01-01

    The aim of this paper is two-fold: (i) to describe the development of a new measuring instrument for quality of care from the perspective of the users of local authority Occupational Therapy (OT) services, and (ii) to evaluate the potential of the new instrument as a standardized approach for the

  16. 29 CFR 1604.2 - Sex as a bona fide occupational qualification.

    Science.gov (United States)

    2010-07-01

    ... example, the assumption that the turnover rate among women is higher than among men. (ii) The refusal to... occupational qualification, e.g., an actor or actress. (b) Effect of sex-oriented State employment legislation... wage and premium pay for overtime be provided for female employees. An employer will be deemed to have...

  17. Does occupational noise cause asymmetric hearing loss?

    Science.gov (United States)

    Dobie, Robert A

    2014-01-01

    Determine whether occupational noise exposure increases audiometric asymmetry. Audiograms were performed on 2044 men from the Occupational Noise and Hearing Survey, representing four groups based on preliminary screening (for previous noise exposure, otologic history, and otoscopy) and current occupational noise exposure. The effects of current noise exposure on audiometric asymmetry were tested using ANCOVA, with binaural average thresholds as covariates. There were no significant differences in asymmetry attributable to current occupational noise exposure. Occupational noise exposure does not usually cause or exacerbate audiometric asymmetry.

  18. Polímeros como modificadores asfálticos

    Directory of Open Access Journals (Sweden)

    Letícia SocaI da Silva

    2009-12-01

    Full Text Available

    Neste trabalho foram preparadas diferentes misturas de ligante asfáltico modificado com polímeros. Foram utilizadas quatro amostras de polímeros, sendo duas de SBS, uma de SEBS e uma de Polietileno Modificado, as quais foram caracterizadas quanto a sua estrutura e propriedades térmicas através de técnicas de Ressonância Magnética Nuclear (RMN, Cromatografia por Permeação a Gel (GPC, Análise Termogravimétrica (TGA e Calorimetria Diferencial de Varredura (DSC. O ligante modificado foi avaliado quanto a sua viscosidade, retorno elástico, comportamento reológico e estabilidade à estocagem. Foram correlacionadas a estrutura química e as transições térmicas dos polímeros com as características do ligante modificado. Os polímeros do tipo SBS foram os melhores modificadores de asfalto, quando comparado com os demais polímeros avaliados.

  19. Ideologia e comportamento político no eleitorado brasileiro

    Directory of Open Access Journals (Sweden)

    Carlos Oliveira

    2015-12-01

    Full Text Available Este artigo aborda o papel das ideologias esquerda edireita sobre o comportamento político do eleitorado brasileiro, com foco na constrição que essas ideologias devem gerar sobre suas preferências políticas. Em outras palavras, avalia se o eleitor estrutura suas atitudes políticas em consonância com a ideologia de que diz ser adepto. Usando dados de survey do Estudo Eleitoral Brasileiro (Eseb, os achados indicam que parte significativa do eleitorado do Brasil nem se autoposiciona ideologicamente. Pior ainda, a ideologia declarada por poucos eleitores não constringe suas preferências políticas. Seguramente, a grande maioria dos eleitores não conhece a complexidade envolta no antagonismo programático de cada lado do espectro ideológico. Conclui-se, portanto, que as ideologias não são importantes para o comportamento político do eleitorado brasileiro.

  20. Por que rir da Filosofia Política?: Abertura

    Directory of Open Access Journals (Sweden)

    Lessa Renato

    1998-01-01

    Full Text Available As diferentes intervenções que compuseram este debate têm como referência comum uma reflexão sobre os lugares da Filosofia Política na tradição disciplinar que designamos como Ciência Política. Recusando a perspectiva que dissocia a Filosofia Política da dimensão empiricamente orientada da disciplina, os argumentos apresentados destacam o papel de fertilização de formas de vida cumprido pela primeira. A agenda dos pesquisadores devotados à boa faina da investigação empírica foi, e segue sendo, em grande medida definida e configurada por exercícios prévios de invenção social e política e por decisões de ordem ontológica, epistemológica e retórica. Neste sentido, a distinção entre ciência e filosofia é, além de obscurantista e marcada por enorme otimismo epistemológico, sintoma de um desconhecimento forte com relação à história do conhecimento político.