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Sample records for points sensitivity analyses

  1. Uncertainty and Sensitivity Analyses Plan

    International Nuclear Information System (INIS)

    Simpson, J.C.; Ramsdell, J.V. Jr.

    1993-04-01

    Hanford Environmental Dose Reconstruction (HEDR) Project staff are developing mathematical models to be used to estimate the radiation dose that individuals may have received as a result of emissions since 1944 from the US Department of Energy's (DOE) Hanford Site near Richland, Washington. An uncertainty and sensitivity analyses plan is essential to understand and interpret the predictions from these mathematical models. This is especially true in the case of the HEDR models where the values of many parameters are unknown. This plan gives a thorough documentation of the uncertainty and hierarchical sensitivity analysis methods recommended for use on all HEDR mathematical models. The documentation includes both technical definitions and examples. In addition, an extensive demonstration of the uncertainty and sensitivity analysis process is provided using actual results from the Hanford Environmental Dose Reconstruction Integrated Codes (HEDRIC). This demonstration shows how the approaches used in the recommended plan can be adapted for all dose predictions in the HEDR Project

  2. EPA Region 1 Environmentally Sensitive Areas (Points)

    Data.gov (United States)

    U.S. Environmental Protection Agency — This coverage represents point equivalents of environmentally sensitive areas in EPA New England. This coverage represents polygon equivalents of environmentally...

  3. Sensitivity in risk analyses with uncertain numbers.

    Energy Technology Data Exchange (ETDEWEB)

    Tucker, W. Troy; Ferson, Scott

    2006-06-01

    Sensitivity analysis is a study of how changes in the inputs to a model influence the results of the model. Many techniques have recently been proposed for use when the model is probabilistic. This report considers the related problem of sensitivity analysis when the model includes uncertain numbers that can involve both aleatory and epistemic uncertainty and the method of calculation is Dempster-Shafer evidence theory or probability bounds analysis. Some traditional methods for sensitivity analysis generalize directly for use with uncertain numbers, but, in some respects, sensitivity analysis for these analyses differs from traditional deterministic or probabilistic sensitivity analyses. A case study of a dike reliability assessment illustrates several methods of sensitivity analysis, including traditional probabilistic assessment, local derivatives, and a ''pinching'' strategy that hypothetically reduces the epistemic uncertainty or aleatory uncertainty, or both, in an input variable to estimate the reduction of uncertainty in the outputs. The prospects for applying the methods to black box models are also considered.

  4. Transient point source analyses in the ANTARES neutrino telescope

    Energy Technology Data Exchange (ETDEWEB)

    Sánchez Losa, Agustín, E-mail: Agustin.Sanchez@ific.uv.es

    2014-04-01

    The ANTARES telescope, with a duty cycle close to unity and a full hemisphere of the sky at all the times visible, is well suited to detect neutrinos produced in astrophysical transient sources. Assuming a known neutrino production period, the background and the sensitivity can be drastically improved by selecting a narrow time window around it. GRBs, μ-quasars and AGNs are particularly attractive potential neutrino point sources since neutrinos and gamma-rays may be produced in hadronic interactions with the surrounding medium as they are the most likely sources of the observed ultra high energy cosmic rays. A strong correlation between the gamma-ray and the neutrino fluxes is expected in this scenario. ANTARES data has been analyzed in various transient source analyses with the goal of detecting cosmic neutrinos from GRBs, μ-quasars and AGNs. The sensitivity of a standard time-integrated point source search can be improved by a factor 2–3 by looking for neutrinos only during the most probable emission time. This information can be provided by the different satellite telescope types on the X-rays and γ-rays wavelengths. The results of these different analyses will be presented.

  5. Photovoltaic System Modeling. Uncertainty and Sensitivity Analyses

    Energy Technology Data Exchange (ETDEWEB)

    Hansen, Clifford W. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Martin, Curtis E. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-08-01

    We report an uncertainty and sensitivity analysis for modeling AC energy from ph otovoltaic systems . Output from a PV system is predicted by a sequence of models. We quantify u ncertainty i n the output of each model using empirical distribution s of each model's residuals. We propagate uncertainty through the sequence of models by sampli ng these distributions to obtain a n empirical distribution of a PV system's output. We consider models that: (1) translate measured global horizontal, direct and global diffuse irradiance to plane - of - array irradiance; (2) estimate effective irradiance; (3) predict cell temperature; (4) estimate DC voltage, current and power ; (5) reduce DC power for losses due to inefficient maximum power point tracking or mismatch among modules; and (6) convert DC to AC power . O ur analysis consider s a notional PV system com prising an array of FirstSolar FS - 387 modules and a 250 kW AC inverter ; we use measured irradiance and weather at Albuquerque, NM. We found the uncertainty in PV syste m output to be relatively small, on the order of 1% for daily energy. We found that unce rtainty in the models for POA irradiance and effective irradiance to be the dominant contributors to uncertainty in predicted daily energy. Our analysis indicates that efforts to reduce the uncertainty in PV system output predictions may yield the greatest improvements by focusing on the POA and effective irradiance models.

  6. Analysing Music with Point-Set Compression Algorithms

    DEFF Research Database (Denmark)

    Meredith, David

    2016-01-01

    Several point-set pattern-discovery and compression algorithms designed for analysing music are reviewed and evaluated. Each algorithm takes as input a point-set representation of a score in which each note is represented as a point in pitch-time space. Each algorithm computes the maximal transla...... and sections in pieces of classical music. On the first task, the best-performing algorithms achieved success rates of around 84%. In the second task, the best algorithms achieved mean F1 scores of around 0.49, with scores for individual pieces rising as high as 0.71.......Several point-set pattern-discovery and compression algorithms designed for analysing music are reviewed and evaluated. Each algorithm takes as input a point-set representation of a score in which each note is represented as a point in pitch-time space. Each algorithm computes the maximal...

  7. Sensitivity of surface meteorological analyses to observation networks

    Science.gov (United States)

    Tyndall, Daniel Paul

    A computationally efficient variational analysis system for two-dimensional meteorological fields is developed and described. This analysis approach is most efficient when the number of analysis grid points is much larger than the number of available observations, such as for large domain mesoscale analyses. The analysis system is developed using MATLAB software and can take advantage of multiple processors or processor cores. A version of the analysis system has been exported as a platform independent application (i.e., can be run on Windows, Linux, or Macintosh OS X desktop computers without a MATLAB license) with input/output operations handled by commonly available internet software combined with data archives at the University of Utah. The impact of observation networks on the meteorological analyses is assessed by utilizing a percentile ranking of individual observation sensitivity and impact, which is computed by using the adjoint of the variational surface assimilation system. This methodology is demonstrated using a case study of the analysis from 1400 UTC 27 October 2010 over the entire contiguous United States domain. The sensitivity of this approach to the dependence of the background error covariance on observation density is examined. Observation sensitivity and impact provide insight on the influence of observations from heterogeneous observing networks as well as serve as objective metrics for quality control procedures that may help to identify stations with significant siting, reporting, or representativeness issues.

  8. Measuring sensitivity in pharmacoeconomic studies. Refining point sensitivity and range sensitivity by incorporating probability distributions.

    Science.gov (United States)

    Nuijten, M J

    1999-07-01

    The aim of the present study is to describe a refinement of a previously presented method, based on the concept of point sensitivity, to deal with uncertainty in economic studies. The original method was refined by the incorporation of probability distributions which allow a more accurate assessment of the level of uncertainty in the model. In addition, a bootstrap method was used to create a probability distribution for a fixed input variable based on a limited number of data points. The original method was limited in that the sensitivity measurement was based on a uniform distribution of the variables and that the overall sensitivity measure was based on a subjectively chosen range which excludes the impact of values outside the range on the overall sensitivity. The concepts of the refined method were illustrated using a Markov model of depression. The application of the refined method substantially changed the ranking of the most sensitive variables compared with the original method. The response rate became the most sensitive variable instead of the 'per diem' for hospitalisation. The refinement of the original method yields sensitivity outcomes, which greater reflect the real uncertainty in economic studies.

  9. SENSITIVITY ANALYSIS FOR SALTSTONE DISPOSAL UNIT COLUMN DEGRADATION ANALYSES

    Energy Technology Data Exchange (ETDEWEB)

    Flach, G.

    2014-10-28

    PORFLOW related analyses supporting a Sensitivity Analysis for Saltstone Disposal Unit (SDU) column degradation were performed. Previous analyses, Flach and Taylor 2014, used a model in which the SDU columns degraded in a piecewise manner from the top and bottom simultaneously. The current analyses employs a model in which all pieces of the column degrade at the same time. Information was extracted from the analyses which may be useful in determining the distribution of Tc-99 in the various SDUs throughout time and in determining flow balances for the SDUs.

  10. Balancing data sharing requirements for analyses with data sensitivity

    Science.gov (United States)

    Jarnevich, C.S.; Graham, J.J.; Newman, G.J.; Crall, A.W.; Stohlgren, T.J.

    2007-01-01

    Data sensitivity can pose a formidable barrier to data sharing. Knowledge of species current distributions from data sharing is critical for the creation of watch lists and an early warning/rapid response system and for model generation for the spread of invasive species. We have created an on-line system to synthesize disparate datasets of non-native species locations that includes a mechanism to account for data sensitivity. Data contributors are able to mark their data as sensitive. This data is then 'fuzzed' in mapping applications and downloaded files to quarter-quadrangle grid cells, but the actual locations are available for analyses. We propose that this system overcomes the hurdles to data sharing posed by sensitive data. ?? 2006 Springer Science+Business Media B.V.

  11. Capsaicin-induced central sensitization evokes segmental increases in trigger point sensitivity in humans.

    Science.gov (United States)

    Srbely, John Z; Dickey, James P; Bent, Leah R; Lee, David; Lowerison, Mark

    2010-07-01

    This study investigated whether inducing central sensitization evokes segmental increases in trigger point pressure sensitivity. We evoked central sensitization at the C(5) segment and validated its presence via mechanical cutaneous sensitivity (brush allodynia) testing. Trigger point pressure sensitivity was quantified using the pain pressure threshold (PPT) value. A 50 cm(2) area of the C(5) dermatome at the right lateral elbow was pretreated with 45 degrees heat for 10 minutes. Test subjects (n = 20) then received topical capsaicin cream (0.075%; Medicis, Toronto, Canada) to the C(5) dermatome, whereas control subjects (n = 20) received a topical placebo cream (Biotherm Massage, Montreal, Canada). PPT readings were recorded from the infraspinatus (C(5,6)) and gluteus medius (L(4,5)S(1)) trigger points at zero (pre-intervention), 10, 20, and 30 minutes after intervention; all PPT readings were normalized to pre-intervention (baseline) values. The difference between the PPT readings at the 2 trigger point sites represents the direct influence of segmental mechanisms on the trigger point sensitivity at the infraspinatus site (PPT(seg)). Test subjects demonstrated statistically significant increases in Total Allodynia scores and significant decreases in PPT(seg) at 10, 20, and 30 minutes after application, when compared with control subjects. These results demonstrate that increases in central sensitization evoke increases in trigger point pressure sensitivity in segmentally related muscles. Myofascial pain is the most common form of musculoskeletal pain. Myofascial trigger points play an important role in the clinical manifestation of myofascial pain syndrome. Elucidating the role of central sensitization in the pathophysiology of trigger points is fundamental to developing optimal strategies in the management of myofascial pain syndrome.

  12. Sensitivity Analyses for Robust Causal Inference from Mendelian Randomization Analyses with Multiple Genetic Variants.

    Science.gov (United States)

    Burgess, Stephen; Bowden, Jack; Fall, Tove; Ingelsson, Erik; Thompson, Simon G

    2017-01-01

    Mendelian randomization investigations are becoming more powerful and simpler to perform, due to the increasing size and coverage of genome-wide association studies and the increasing availability of summarized data on genetic associations with risk factors and disease outcomes. However, when using multiple genetic variants from different gene regions in a Mendelian randomization analysis, it is highly implausible that all the genetic variants satisfy the instrumental variable assumptions. This means that a simple instrumental variable analysis alone should not be relied on to give a causal conclusion. In this article, we discuss a range of sensitivity analyses that will either support or question the validity of causal inference from a Mendelian randomization analysis with multiple genetic variants. We focus on sensitivity analyses of greatest practical relevance for ensuring robust causal inferences, and those that can be undertaken using summarized data. Aside from cases in which the justification of the instrumental variable assumptions is supported by strong biological understanding, a Mendelian randomization analysis in which no assessment of the robustness of the findings to violations of the instrumental variable assumptions has been made should be viewed as speculative and incomplete. In particular, Mendelian randomization investigations with large numbers of genetic variants without such sensitivity analyses should be treated with skepticism.

  13. Adjoint sensitivity and uncertainty analyses in Monte Carlo forward calculations

    International Nuclear Information System (INIS)

    Shim, Hyung Jin; Kim, Chang Hyo

    2011-01-01

    The adjoint-weighted perturbation (AWP) method, in which the required adjoint flux is estimated in the course of Monte Carlo (MC) forward calculations, has recently been proposed as an alternative to the conventional MC perturbation techniques, such as the correlated sampling and differential operator sampling (DOS) methods. The equivalence of the first-order AWP method and first-order DOS method with the fission source perturbation taken into account is proven. An algorithm for the AWP calculations is implemented in the Seoul National University MC code McCARD and applied to the sensitivity and uncertainty analyses of the Godiva and Bigten criticalities. (author)

  14. Dual interferometry with a tunable point of minimum magnetic sensitivity

    Science.gov (United States)

    Gomez, Eduardo; Hamzeloui, Saeed; Martinez, Daniel; Abediyeh, Vahide; Arias, Nieves; Valenzuela, Victor Manuel

    2016-05-01

    The clock transition is well known for its minimum magnetic sensitivity at B = 0. The hyperfine transition between F = 1, m = -1 and F = 2, m = 1 in 87Rb also shows a point of minimum magnetic sensitivity but it happens at a field of 3.2 Gauss. An interferometer that uses a mixture of the previous two transitions gives a minimum of magnetic sensitivity at a tunable value of the magnetic field between 0 and 3.2 Gauss. The desired magnetic field value can be selected by varying the population in each transition. The relative populations are controlled with a microwave pulse joining states in both interferometers. Support from CONACYT and Fundacion Marcos Moshinsky.

  15. Sensitivity analysis of point and parametric pedotransfer functions for estimating water retention of soils in Algeria

    Directory of Open Access Journals (Sweden)

    S. Touil

    2016-12-01

    0.0636 cm3 cm−3, respectively. The results of global sensitivity analyses (GSAs showed that the mathematical formalism of PTFs and their input variables reacted differently in terms of point pressure and texture. The point and parametric PTFs were sensitive mainly to the sand fraction in the fine- and medium-textural classes. The use of clay percentage (C % and bulk density (BD as inputs in the medium-textural class improved the estimation of PTFs at −33 kPa.

  16. Sensitivity and uncertainty analyses in aging risk-based prioritizations

    International Nuclear Information System (INIS)

    Hassan, M.; Uryas'ev, S.; Vesely, W.E.

    1993-01-01

    Aging risk evaluations of nuclear power plants using Probabilistic Risk Analyses (PRAs) involve assessments of the impact of aging structures, systems, and components (SSCs) on plant core damage frequency (CDF). These assessments can be used to prioritize the contributors to aging risk reflecting the relative risk potential of the SSCs. Aging prioritizations are important for identifying the SSCs contributing most to plant risk and can provide a systematic basis on which aging risk control and management strategies for a plant can be developed. However, these prioritizations are subject to variabilities arising from uncertainties in data, and/or from various modeling assumptions. The objective of this paper is to present an evaluation of the sensitivity of aging prioritizations of active components to uncertainties in aging risk quantifications. Approaches for robust prioritization of SSCs also are presented which are less susceptible to the uncertainties

  17. Sensitivity analyses on in-vessel hydrogen generation for KNGR

    International Nuclear Information System (INIS)

    Kim, See Darl; Park, S.Y.; Park, S.H.; Park, J.H.

    2001-03-01

    Sensitivity analyses for the in-vessel hydrogen generation, using the MELCOR program, are described in this report for the Korean Next Generation Reactor. The typical accident sequences of a station blackout and a large LOCA scenario are selected. A lower head failure model, a Zircaloy oxidation reaction model and a B 4 C reaction model are considered for the sensitivity parameters. As for the base case, 1273.15K for a failure temperature of the penetrations or the lower head, an Urbanic-Heidrich correlation for the Zircaloy oxidation reaction model and the B 4 C reaction model are used. Case 1 used 1650K as the failure temperature for the penetrations and Case 2 considered creep rupture instead of penetration failure. Case 3 used a MATPRO-EG and G correlation for the Zircaloy oxidation reaction model and Case 4 turned off the B 4 C reaction model. The results of the studies are summarized below : (1) When the penetration failure temperature is higher, or the creep rupture failure model is considered, the amount of hydrogen increases for two sequences. (2) When the MATPRO-EG and G correlation for a Zircaloy oxidation reaction is considered, the amount of hydrogen is less than the Urbanic-Heidrich correlation (Base case) for both scenarios. (3) When the B 4 C reaction model turns off, the amount of hydrogen decreases for two sequences

  18. Point process analyses of variations in smoking rate by setting, mood, gender, and dependence

    Science.gov (United States)

    Shiffman, Saul; Rathbun, Stephen L.

    2010-01-01

    The immediate emotional and situational antecedents of ad libitum smoking are still not well understood. We re-analyzed data from Ecological Momentary Assessment using novel point-process analyses, to assess how craving, mood, and social setting influence smoking rate, as well as assessing the moderating effects of gender and nicotine dependence. 304 smokers recorded craving, mood, and social setting using electronic diaries when smoking and at random nonsmoking times over 16 days of smoking. Point-process analysis, which makes use of the known random sampling scheme for momentary variables, examined main effects of setting and interactions with gender and dependence. Increased craving was associated with higher rates of smoking, particularly among women. Negative affect was not associated with smoking rate, even in interaction with arousal, but restlessness was associated with substantially higher smoking rates. Women's smoking tended to be less affected by negative affect. Nicotine dependence had little moderating effect on situational influences. Smoking rates were higher when smokers were alone or with others smoking, and smoking restrictions reduced smoking rates. However, the presence of others smoking undermined the effects of restrictions. The more sensitive point-process analyses confirmed earlier findings, including the surprising conclusion that negative affect by itself was not related to smoking rates. Contrary to hypothesis, men's and not women's smoking was influenced by negative affect. Both smoking restrictions and the presence of others who are not smoking suppress smoking, but others’ smoking undermines the effects of restrictions. Point-process analyses of EMA data can bring out even small influences on smoking rate. PMID:21480683

  19. Synthesis of Trigeneration Systems: Sensitivity Analyses and Resilience

    Directory of Open Access Journals (Sweden)

    Monica Carvalho

    2013-01-01

    Full Text Available This paper presents sensitivity and resilience analyses for a trigeneration system designed for a hospital. The following information is utilized to formulate an integer linear programming model: (1 energy service demands of the hospital, (2 technical and economical characteristics of the potential technologies for installation, (3 prices of the available utilities interchanged, and (4 financial parameters of the project. The solution of the model, minimizing the annual total cost, provides the optimal configuration of the system (technologies installed and number of pieces of equipment and the optimal operation mode (operational load of equipment, interchange of utilities with the environment, convenience of wasting cogenerated heat, etc. at each temporal interval defining the demand. The broad range of technical, economic, and institutional uncertainties throughout the life cycle of energy supply systems for buildings makes it necessary to delve more deeply into the fundamental properties of resilient systems: feasibility, flexibility and robustness. The resilience of the obtained solution is tested by varying, within reasonable limits, selected parameters: energy demand, amortization and maintenance factor, natural gas price, self-consumption of electricity, and time-of-delivery feed-in tariffs.

  20. Sensitivity analyses of the peach bottom turbine trip 2 experiment

    International Nuclear Information System (INIS)

    Bousbia Salah, A.; D'Auria, F.

    2003-01-01

    In the light of the sustained development in computer technology, the possibilities for code calculations in predicting more realistic transient scenarios in nuclear power plants have been enlarged substantially. Therefore, it becomes feasible to perform 'Best-estimate' simulations through the incorporation of three-dimensional modeling of reactor core into system codes. This method is particularly suited for complex transients that involve strong feedback effects between thermal-hydraulics and kinetics as well as to transient involving local asymmetric effects. The Peach bottom turbine trip test is characterized by a prompt core power excursion followed by a self limiting power behavior. To emphasize and understand the feedback mechanisms involved during this transient, a series of sensitivity analyses were carried out. This should allow the characterization of discrepancies between measured and calculated trends and assess the impact of the thermal-hydraulic and kinetic response of the used models. On the whole, the data comparison revealed a close dependency of the power excursion with the core feedback mechanisms. Thus for a better best estimate simulation of the transient, both of the thermal-hydraulic and the kinetic models should be made more accurate. (author)

  1. Synthesis of Trigeneration Systems: Sensitivity Analyses and Resilience

    Science.gov (United States)

    Carvalho, Monica; Lozano, Miguel A.; Ramos, José; Serra, Luis M.

    2013-01-01

    This paper presents sensitivity and resilience analyses for a trigeneration system designed for a hospital. The following information is utilized to formulate an integer linear programming model: (1) energy service demands of the hospital, (2) technical and economical characteristics of the potential technologies for installation, (3) prices of the available utilities interchanged, and (4) financial parameters of the project. The solution of the model, minimizing the annual total cost, provides the optimal configuration of the system (technologies installed and number of pieces of equipment) and the optimal operation mode (operational load of equipment, interchange of utilities with the environment, convenience of wasting cogenerated heat, etc.) at each temporal interval defining the demand. The broad range of technical, economic, and institutional uncertainties throughout the life cycle of energy supply systems for buildings makes it necessary to delve more deeply into the fundamental properties of resilient systems: feasibility, flexibility and robustness. The resilience of the obtained solution is tested by varying, within reasonable limits, selected parameters: energy demand, amortization and maintenance factor, natural gas price, self-consumption of electricity, and time-of-delivery feed-in tariffs. PMID:24453881

  2. Synthesis of trigeneration systems: sensitivity analyses and resilience.

    Science.gov (United States)

    Carvalho, Monica; Lozano, Miguel A; Ramos, José; Serra, Luis M

    2013-01-01

    This paper presents sensitivity and resilience analyses for a trigeneration system designed for a hospital. The following information is utilized to formulate an integer linear programming model: (1) energy service demands of the hospital, (2) technical and economical characteristics of the potential technologies for installation, (3) prices of the available utilities interchanged, and (4) financial parameters of the project. The solution of the model, minimizing the annual total cost, provides the optimal configuration of the system (technologies installed and number of pieces of equipment) and the optimal operation mode (operational load of equipment, interchange of utilities with the environment, convenience of wasting cogenerated heat, etc.) at each temporal interval defining the demand. The broad range of technical, economic, and institutional uncertainties throughout the life cycle of energy supply systems for buildings makes it necessary to delve more deeply into the fundamental properties of resilient systems: feasibility, flexibility and robustness. The resilience of the obtained solution is tested by varying, within reasonable limits, selected parameters: energy demand, amortization and maintenance factor, natural gas price, self-consumption of electricity, and time-of-delivery feed-in tariffs.

  3. A study of the pointed observation methods and sensitivity of HXMT

    International Nuclear Information System (INIS)

    Jin Jiang; Chen Yong; Zhang Shu; Li Xinqiao; Li Gang; Zhang Shuangnan; Department of Physics, Tsinghua University Beijing

    2010-01-01

    The Hard X-ray Modulation Telescope (HXMT) is an X-ray astronomy satellite consisting of three slat-collimated instruments, the High Energy X-ray Instrument (HE), the Medium Energy X-ray Instrument (ME), and the Low Energy X-ray Instrument (LE). HXMT will carry out an all sky survey and make pointed observations in the 1-250 keV energy band. In order to get the source and background fluxes simultaneously in the pointed observations, two methods, i.e., the combined field of view (FOV) method and the off-axis pointing method are proposed in this paper. Comprehensive analyses of the sensitivities of the three instruments by using these two methods are presented, respectively. It is found that the off-axis pointing method has a higher sensitivity for HE and ME but a lower sensitivity for LE. Since the axes of the three instruments are aligned along the same direction, the off-axis pointing method is recommended as the main method in the pointed observation for HXMT; the combined FOV method can be used when LE is the most relevant instrument in order to satisfy the scientific objective of the observation. (authors)

  4. Geographic Response Plan (GRP) Sensitive Site Points (Editable), Guam, 2016, US EPA Region 9

    Data.gov (United States)

    U.S. Environmental Protection Agency — This is an editable point feature data set with points over Apra Harbor in Guam. These points represent sensitive sites such as access points for public use and...

  5. Accelerated safety analyses - structural analyses Phase I - structural sensitivity evaluation of single- and double-shell waste storage tanks

    International Nuclear Information System (INIS)

    Becker, D.L.

    1994-11-01

    Accelerated Safety Analyses - Phase I (ASA-Phase I) have been conducted to assess the appropriateness of existing tank farm operational controls and/or limits as now stipulated in the Operational Safety Requirements (OSRs) and Operating Specification Documents, and to establish a technical basis for the waste tank operating safety envelope. Structural sensitivity analyses were performed to assess the response of the different waste tank configurations to variations in loading conditions, uncertainties in loading parameters, and uncertainties in material characteristics. Extensive documentation of the sensitivity analyses conducted and results obtained are provided in the detailed ASA-Phase I report, Structural Sensitivity Evaluation of Single- and Double-Shell Waste Tanks for Accelerated Safety Analysis - Phase I. This document provides a summary of the accelerated safety analyses sensitivity evaluations and the resulting findings

  6. On accuracy problems for semi-analytical sensitivity analyses

    DEFF Research Database (Denmark)

    Pedersen, P.; Cheng, G.; Rasmussen, John

    1989-01-01

    The semi-analytical method of sensitivity analysis combines ease of implementation with computational efficiency. A major drawback to this method, however, is that severe accuracy problems have recently been reported. A complete error analysis for a beam problem with changing length is carried out...

  7. Sensitivity analyses for simulating pesticide impacts on honey bee colonies

    Science.gov (United States)

    We employ Monte Carlo simulation and sensitivity analysis techniques to describe the population dynamics of pesticide exposure to a honey bee colony using the VarroaPop+Pesticide model. Simulations are performed of hive population trajectories with and without pesticide exposure to determine the eff...

  8. Respiratory sensitization: toxicological point of view on the available assays.

    Science.gov (United States)

    Chary, Aline; Hennen, Jennifer; Klein, Sebastian G; Serchi, Tommaso; Gutleb, Arno C; Blömeke, Brunhilde

    2018-02-01

    Respiratory sensitization as a consequence of exposure to chemical products has increased over the last decades, leading to an increase of morbidity. The increased use of synthetic compounds resulted in an exponential growth of substances to which we are potentially exposed on a daily basis. Some of them are known to induce respiratory sensitization, meaning that they can trigger the development of allergies. In the past, animal studies provided useful results for the understanding of mechanisms involved in the development of respiratory allergies. However, the mechanistic understanding of the involved cellular effects is still limited. Currently, no in vitro or in vivo models are validated to identify chemical respiratory sensitizers. Nonetheless, chemical respiratory sensitizers elicit a positive response in validated assays for skin sensitization. In this review, we will discuss how these assays could be used for respiratory sensitization and if necessary, what can be learnt from these assays to develop a model to assess the respiratory sensitizing potential of chemicals. In the last decades, much work has been done to study the respiratory toxicity of inhaled compounds especially in developing in vitro assays grown at the air-liquid interface. We will discuss how possibly the tests currently used to investigate general particle toxicity could be transformed to investigate respiratory sensitization. In the present review, we describe the most known mechanism involved in the sensitization process and the experimental in vivo and alternative in vitro models, which are currently available and how to adapt and improve existing models to study respiratory sensitization.

  9. Peer review of HEDR uncertainty and sensitivity analyses plan

    Energy Technology Data Exchange (ETDEWEB)

    Hoffman, F.O.

    1993-06-01

    This report consists of a detailed documentation of the writings and deliberations of the peer review panel that met on May 24--25, 1993 in Richland, Washington to evaluate your draft report ``Uncertainty/Sensitivity Analysis Plan`` (PNWD-2124 HEDR). The fact that uncertainties are being considered in temporally and spatially varying parameters through the use of alternative time histories and spatial patterns deserves special commendation. It is important to identify early those model components and parameters that will have the most influence on the magnitude and uncertainty of the dose estimates. These are the items that should be investigated most intensively prior to committing to a final set of results.

  10. SPES3 Facility RELAP5 Sensitivity Analyses on the Containment System for Design Review

    International Nuclear Information System (INIS)

    Achilli, A.; Congiu, C.; Ferri, R.; Bianchi, F.; Meloni, P.; Grgic, D.; Dzodzo, M.

    2012-01-01

    An Italian MSE R and D programme on Nuclear Fission is funding, through ENEA, the design and testing of SPES3 facility at SIET, for IRIS reactor simulation. IRIS is a modular, medium size, advanced, integral PWR, developed by an international consortium of utilities, industries, research centres and universities. SPES3 simulates the primary, secondary and containment systems of IRIS, with 1:100 volume scale, full elevation and prototypical thermal-hydraulic conditions. The RELAP5 code was extensively used in support to the design of the facility to identify criticalities and weak points in the reactor simulation. FER, at Zagreb University, performed the IRIS reactor analyses with the RELAP5 and GOTHIC coupled codes. The comparison between IRIS and SPES3 simulation results led to a simulation-design feedback process with step-by-step modifications of the facility design, up to the final configuration. For this, a series of sensitivity cases was run to investigate specific aspects affecting the trend of the main parameters of the plant, as the containment pressure and EHRS removed power, to limit fuel clad temperature excursions during accidental transients. This paper summarizes the sensitivity analyses on the containment system that allowed to review the SPES3 facility design and confirm its capability to appropriately simulate the IRIS plant.

  11. SPES3 Facility RELAP5 Sensitivity Analyses on the Containment System for Design Review

    Directory of Open Access Journals (Sweden)

    Andrea Achilli

    2012-01-01

    Full Text Available An Italian MSE R&D programme on Nuclear Fission is funding, through ENEA, the design and testing of SPES3 facility at SIET, for IRIS reactor simulation. IRIS is a modular, medium size, advanced, integral PWR, developed by an international consortium of utilities, industries, research centres and universities. SPES3 simulates the primary, secondary and containment systems of IRIS, with 1:100 volume scale, full elevation and prototypical thermal-hydraulic conditions. The RELAP5 code was extensively used in support to the design of the facility to identify criticalities and weak points in the reactor simulation. FER, at Zagreb University, performed the IRIS reactor analyses with the RELAP5 and GOTHIC coupled codes. The comparison between IRIS and SPES3 simulation results led to a simulation-design feedback process with step-by-step modifications of the facility design, up to the final configuration. For this, a series of sensitivity cases was run to investigate specific aspects affecting the trend of the main parameters of the plant, as the containment pressure and EHRS removed power, to limit fuel clad temperature excursions during accidental transients. This paper summarizes the sensitivity analyses on the containment system that allowed to review the SPES3 facility design and confirm its capability to appropriately simulate the IRIS plant.

  12. Spatially resolved synchrotron-induced X-ray fluorescence analyses of metal point drawings and their mysterious inscriptions

    International Nuclear Information System (INIS)

    Reiche, Ina; Radtke, Martin; Berger, Achim; Goerner, Wolf; Ketelsen, Thomas; Merchel, Silke; Riederer, Josef; Riesemeier, Heinrich; Roth, Michael

    2004-01-01

    Synchrotron-induced X-ray fluorescence (Sy-XRF) analysis was used to study the chemical composition of precious Renaissance silverpoint drawings. Drawings by famous artists such as Albrecht Duerer (1471-1528) and Jan van Eyck (approximately 1395-1441) must be investigated non-destructively. Moreover, extremely sensitive synchrotron- or accelerator-based techniques are needed since only small quantities of silver are deposited on the paper. New criteria for attributing these works to a particular artist could be established based on the analysis of the chemical composition of the metal points used. We illustrate how analysis can give new art historical information by means of two case studies. Two particular drawings, one of Albrecht Duerer, showing a profile portrait of his closest friend, 'Willibald Pirckheimer' (1503), and a second one attributed to Jan van Eyck, showing a 'Portrait of an elderly man', often named 'Niccolo Albergati', are the object of intense art historical controversy. Both drawings show inscriptions next to the figures. Analyses by Sy-XRF could reveal the same kind of silverpoint for the Pirckheimer portrait and its mysterious Greek inscription, contrary to the drawing by Van Eyck where at least three different metal points were applied. Two different types of silver marks were found in this portrait. Silver containing gold marks were detected in the inscriptions and over-subscriptions. This is the first evidence of the use of gold points for metal point drawings in the Middle Ages

  13. A different point of view on the sensitivity of quartz crystal microbalance sensors

    International Nuclear Information System (INIS)

    Arnau, Antonio; Montagut, Yeison; García, José V; Jiménez, Yolanda

    2009-01-01

    In this paper, the sensitivity of a quartz crystal microbalance (QCM) sensor is analysed and discussed in terms of the phase change versus the surface mass change, instead of the classical sensitivity in terms of the resonant frequency change derived from the well-known Sauerbrey equation. The detection sensitivity derived from the Sauerbrey equation is a theoretical detection capability in terms of the frequency change versus the mass change, which increases with the square of frequency. However, when a specific application and measuring system are considered, the detection capability of the QCM sensor must be considered from a different point of view. A new equation is obtained, Δψ ≅ −Δm c /(m q + m L ), which quantifies the phase shift, Δψ, of a fixed frequency signal corresponding to the series resonant frequency of the sensor in a reference state versus a change in the coating mass, Δm c ; m q = η q π/2v q , where η q is the loss viscosity of the unperturbed sensor and v q is the wave propagation speed in quartz, is a parameter which only depends on the physical parameters of the unperturbed resonator and fixes the maximum sensitivity of the sensor and m L = ρ L δ L /2, where ρ L and δ L are, respectively, the liquid density and the wave penetration depth of the wave in the liquid, is the equivalent surface mass density associated with the oscillatory movement of the surface of the sensor in contact with a fluid medium. This equation is an approximate equation around the series resonance frequency of the sensor. The simulation results for 10, 50 and 150 MHz resonance frequency QCM sensors probe its validity. A new electronic system is proposed for QCM biosensor applications based on the equation introduced

  14. Sensitivity of Coastal Environments and Wildlife to Spilled Oil: New Hampshire: NESTS (Nest Points)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains sensitive biological resource data for nesting birds in New Hampshire. Vector points in this data set represent locations of nesting osprey...

  15. Sensitivity of Coastal Environments and Wildlife to Spilled Oil: Florida Panhandle: INVERTPT (Invertebrate Points)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains sensitive biological resource data for threatened/endangered invertebrate species for the Florida Panhandle. Vector points in this data set...

  16. Sensitivity of Coastal Environments and Wildlife to Spilled Oil: Florida Panhandle: REPTPT (Reptile Points)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains sensitive biological resource data for threatened and endangered reptiles/amphibians for the Florida Panhandle. Vector points in this data set...

  17. Sensitivity of Coastal Environments and Wildlife to Spilled Oil: Mississippi: NESTS (Nest Points)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains sensitive biological resource data for gulls and terns in Mississippi. Vector points in this data set represent bird nesting sites. Species...

  18. Sensitivity study of micro four-point probe measurements on small samples

    DEFF Research Database (Denmark)

    Wang, Fei; Petersen, Dirch Hjorth; Hansen, Torben Mikael

    2010-01-01

    The authors calculate the sensitivities of micro four-point probe sheet resistance and Hall effect measurements to the local transport properties of nonuniform material samples. With in-line four-point probes, the measured dual configuration sheet resistance is more sensitive near the inner two...... probes than near the outer ones. The sensitive area is defined for infinite film, circular, square, and rectangular test pads, and convergent sensitivities are observed for small samples. The simulations show that the Hall sheet resistance RH in micro Hall measurements with position error suppression...... is sensitive to both local carrier density and local carrier mobility because the position calculation is affected in the two pseudo-sheet-resistance measurements needed for the position error suppression. Furthermore, they have also simulated the sensitivity for the resistance difference Delta...

  19. Sensitivity analyses of a colloid-facilitated contaminant transport model for unsaturated heterogeneous soil conditions.

    Science.gov (United States)

    Périard, Yann; José Gumiere, Silvio; Rousseau, Alain N.; Caron, Jean

    2013-04-01

    Certain contaminants may travel faster through soils when they are sorbed to subsurface colloidal particles. Indeed, subsurface colloids may act as carriers of some contaminants accelerating their translocation through the soil into the water table. This phenomenon is known as colloid-facilitated contaminant transport. It plays a significant role in contaminant transport in soils and has been recognized as a source of groundwater contamination. From a mechanistic point of view, the attachment/detachment of the colloidal particles from the soil matrix or from the air-water interface and the straining process may modify the hydraulic properties of the porous media. Šimůnek et al. (2006) developed a model that can simulate the colloid-facilitated contaminant transport in variably saturated porous media. The model is based on the solution of a modified advection-dispersion equation that accounts for several processes, namely: straining, exclusion and attachement/detachement kinetics of colloids through the soil matrix. The solutions of these governing, partial differential equations are obtained using a standard Galerkin-type, linear finite element scheme, implemented in the HYDRUS-2D/3D software (Šimůnek et al., 2012). Modeling colloid transport through the soil and the interaction of colloids with the soil matrix and other contaminants is complex and requires the characterization of many model parameters. In practice, it is very difficult to assess actual transport parameter values, so they are often calibrated. However, before calibration, one needs to know which parameters have the greatest impact on output variables. This kind of information can be obtained through a sensitivity analysis of the model. The main objective of this work is to perform local and global sensitivity analyses of the colloid-facilitated contaminant transport module of HYDRUS. Sensitivity analysis was performed in two steps: (i) we applied a screening method based on Morris' elementary

  20. Sedentary Behaviour Profiling of Office Workers: A Sensitivity Analysis of Sedentary Cut-Points.

    Science.gov (United States)

    Boerema, Simone T; Essink, Gerard B; Tönis, Thijs M; van Velsen, Lex; Hermens, Hermie J

    2015-12-25

    Measuring sedentary behaviour and physical activity with wearable sensors provides detailed information on activity patterns and can serve health interventions. At the basis of activity analysis stands the ability to distinguish sedentary from active time. As there is no consensus regarding the optimal cut-point for classifying sedentary behaviour, we studied the consequences of using different cut-points for this type of analysis. We conducted a battery of sitting and walking activities with 14 office workers, wearing the Promove 3D activity sensor to determine the optimal cut-point (in counts per minute (m·s(-2))) for classifying sedentary behaviour. Then, 27 office workers wore the sensor for five days. We evaluated the sensitivity of five sedentary pattern measures for various sedentary cut-points and found an optimal cut-point for sedentary behaviour of 1660 × 10(-3) m·s(-2). Total sedentary time was not sensitive to cut-point changes within ±10% of this optimal cut-point; other sedentary pattern measures were not sensitive to changes within the ±20% interval. The results from studies analyzing sedentary patterns, using different cut-points, can be compared within these boundaries. Furthermore, commercial, hip-worn activity trackers can implement feedback and interventions on sedentary behaviour patterns, using these cut-points.

  1. Scenario sensitivity analyses performed on the PRESTO-EPA LLW risk assessment models

    International Nuclear Information System (INIS)

    Bandrowski, M.S.

    1988-01-01

    The US Environmental Protection Agency (EPA) is currently developing standards for the land disposal of low-level radioactive waste. As part of the standard development, EPA has performed risk assessments using the PRESTO-EPA codes. A program of sensitivity analysis was conducted on the PRESTO-EPA codes, consisting of single parameter sensitivity analysis and scenario sensitivity analysis. The results of the single parameter sensitivity analysis were discussed at the 1987 DOE LLW Management Conference. Specific scenario sensitivity analyses have been completed and evaluated. Scenario assumptions that were analyzed include: site location, disposal method, form of waste, waste volume, analysis time horizon, critical radionuclides, use of buffer zones, and global health effects

  2. Correlation of the ionisation response at selected points of IC sensitive regions with SEE sensitivity parameters under pulsed laser irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Gordienko, A V; Mavritskii, O B; Egorov, A N; Pechenkin, A A; Savchenkov, D V [National Research Nuclear University ' ' MEPhI' ' (Russian Federation)

    2014-12-31

    The statistics of the ionisation response amplitude measured at selected points and their surroundings within sensitive regions of integrated circuits (ICs) under focused femtosecond laser irradiation is obtained for samples chosen from large batches of two types of ICs. A correlation between these data and the results of full-chip scanning is found for each type. The criteria for express validation of IC single-event effect (SEE) hardness based on ionisation response measurements at selected points are discussed. (laser applications and other topics in quantum electronics)

  3. Comparison of two potato simulation models under climate change. I. Model calibration and sensitivity analyses

    NARCIS (Netherlands)

    Wolf, J.

    2002-01-01

    To analyse the effects of climate change on potato growth and production, both a simple growth model, POTATOS, and a comprehensive model, NPOTATO, were applied. Both models were calibrated and tested against results from experiments and variety trials in The Netherlands. The sensitivity of model

  4. Intraosseous blood samples for point-of-care analysis: agreement between intraosseous and arterial analyses.

    Science.gov (United States)

    Jousi, Milla; Saikko, Simo; Nurmi, Jouni

    2017-09-11

    Point-of-care (POC) testing is highly useful when treating critically ill patients. In case of difficult vascular access, the intraosseous (IO) route is commonly used, and blood is aspirated to confirm the correct position of the IO-needle. Thus, IO blood samples could be easily accessed for POC analyses in emergency situations. The aim of this study was to determine whether IO values agree sufficiently with arterial values to be used for clinical decision making. Two samples of IO blood were drawn from 31 healthy volunteers and compared with arterial samples. The samples were analysed for sodium, potassium, ionized calcium, glucose, haemoglobin, haematocrit, pH, blood gases, base excess, bicarbonate, and lactate using the i-STAT® POC device. Agreement and reliability were estimated by using the Bland-Altman method and intraclass correlation coefficient calculations. Good agreement was evident between the IO and arterial samples for pH, glucose, and lactate. Potassium levels were clearly higher in the IO samples than those from arterial blood. Base excess and bicarbonate were slightly higher, and sodium and ionised calcium values were slightly lower, in the IO samples compared with the arterial values. The blood gases in the IO samples were between arterial and venous values. Haemoglobin and haematocrit showed remarkable variation in agreement. POC diagnostics of IO blood can be a useful tool to guide treatment in critical emergency care. Seeking out the reversible causes of cardiac arrest or assessing the severity of shock are examples of situations in which obtaining vascular access and blood samples can be difficult, though information about the electrolytes, acid-base balance, and lactate could guide clinical decision making. The analysis of IO samples should though be limited to situations in which no other option is available, and the results should be interpreted with caution, because there is not yet enough scientific evidence regarding the agreement of IO

  5. Experimental and theoretical analyses of package-on-package structure under three-point bending loading

    International Nuclear Information System (INIS)

    Jia Su; Wang Xi-Shu; Ren Huai-Hui

    2012-01-01

    High density packaging is developing toward miniaturization and integration, which causes many difficulties in designing, manufacturing, and reliability testing. Package-on-Package (PoP) is a promising three-dimensional high-density packaging method that integrates a chip scale package (CSP) in the top package and a fine-pitch ball grid array (FBGA) in the bottom package. In this paper, in-situ scanning electron microscopy (SEM) observation is carried out to detect the deformation and damage of the PoP structure under three-point bending loading. The results indicate that the cracks occur in the die of the top package, then cause the crack deflection and bridging in the die attaching layer. Furthermore, the mechanical principles are used to analyse the cracking process of the PoP structure based on the multi-layer laminating hypothesis and the theoretical analysis results are found to be in good agreement with the experimental results. (condensed matter: structural, mechanical, and thermal properties)

  6. Sensitivity of the Baikal neutrino telescope NT-200 to point sources of very high energy neutrinos

    International Nuclear Information System (INIS)

    Krabi, J.; Spiering, C.; Bugaev, E.V.; Klimushin, S.I.

    1991-12-01

    The sensitivity of the deep underwater muon and neutrino detector 'NT-200' in lake Baikal to point sources of extraterrestrial neutrinos is calculated. Results are given for different assumptions on the neutrino source spectrum and the reconstruction capabilities of the detector. (orig.)

  7. Performance Assessment Modeling and Sensitivity Analyses of Generic Disposal System Concepts.

    Energy Technology Data Exchange (ETDEWEB)

    Sevougian, S. David; Freeze, Geoffrey A.; Gardner, William Payton; Hammond, Glenn Edward; Mariner, Paul

    2014-09-01

    directly, rather than through simplified abstractions. It also a llows for complex representations of the source term, e.g., the explicit representation of many individual waste packages (i.e., meter - scale detail of an entire waste emplacement drift). This report fulfills the Generic Disposal System Analysis Work Packa ge Level 3 Milestone - Performance Assessment Modeling and Sensitivity Analyses of Generic Disposal System Concepts (M 3 FT - 1 4 SN08080 3 2 ).

  8. Uncertainty and sensitivity analyses of the complete program system UFOMOD and of selected submodels

    International Nuclear Information System (INIS)

    Fischer, F.; Ehrhardt, J.; Hasemann, I.

    1990-09-01

    Uncertainty and sensitivity studies with the program system UFOMOD have been performed since several years on a submodel basis to get a deeper insight into the propagation of parameter uncertainties through the different modules and to quantify their contribution to the confidence bands of the intermediate and final results of an accident consequence assessment. In a series of investigations with the atmospheric dispersion module, the models describing early protective actions, the models calculating short-term organ doses and the health effects model of the near range subsystem NE of UFOMOD, a great deal of experience has been gained with methods and evaluation techniques for uncertainty and sensitivity analyses. Especially the influence on results of different sampling techniques and sample sizes, parameter distributions and correlations could be quantified and the usefulness of sensitivity measures for the interpretation of results could be demonstrated. In each submodel investigation, the (5%, 95%)-confidende bounds of the complementary cumulative frequency distributions (CCFDs) of various consequence types (activity concentrations of I-131 and Cs-137, individual acute organ doses, individual risks of nonstochastic health effects, and the number of early deaths) were calculated. The corresponding sensitivity analyses for each of these endpoints led to a list of parameters contributing significantly to the variation of mean values and 99% - fractiles. The most important parameters were extracted and combined for the final overall analysis. (orig.) [de

  9. msgbsR: An R package for analysing methylation-sensitive restriction enzyme sequencing data.

    Science.gov (United States)

    Mayne, Benjamin T; Leemaqz, Shalem Y; Buckberry, Sam; Rodriguez Lopez, Carlos M; Roberts, Claire T; Bianco-Miotto, Tina; Breen, James

    2018-02-01

    Genotyping-by-sequencing (GBS) or restriction-site associated DNA marker sequencing (RAD-seq) is a practical and cost-effective method for analysing large genomes from high diversity species. This method of sequencing, coupled with methylation-sensitive enzymes (often referred to as methylation-sensitive restriction enzyme sequencing or MRE-seq), is an effective tool to study DNA methylation in parts of the genome that are inaccessible in other sequencing techniques or are not annotated in microarray technologies. Current software tools do not fulfil all methylation-sensitive restriction sequencing assays for determining differences in DNA methylation between samples. To fill this computational need, we present msgbsR, an R package that contains tools for the analysis of methylation-sensitive restriction enzyme sequencing experiments. msgbsR can be used to identify and quantify read counts at methylated sites directly from alignment files (BAM files) and enables verification of restriction enzyme cut sites with the correct recognition sequence of the individual enzyme. In addition, msgbsR assesses DNA methylation based on read coverage, similar to RNA sequencing experiments, rather than methylation proportion and is a useful tool in analysing differential methylation on large populations. The package is fully documented and available freely online as a Bioconductor package ( https://bioconductor.org/packages/release/bioc/html/msgbsR.html ).

  10. Sensitivity Analyses for Cross-Coupled Parameters in Automotive Powertrain Optimization

    Directory of Open Access Journals (Sweden)

    Pongpun Othaganont

    2014-06-01

    Full Text Available When vehicle manufacturers are developing new hybrid and electric vehicles, modeling and simulation are frequently used to predict the performance of the new vehicles from an early stage in the product lifecycle. Typically, models are used to predict the range, performance and energy consumption of their future planned production vehicle; they also allow the designer to optimize a vehicle’s configuration. Another use for the models is in performing sensitivity analysis, which helps us understand which parameters have the most influence on model predictions and real-world behaviors. There are various techniques for sensitivity analysis, some are numerical, but the greatest insights are obtained analytically with sensitivity defined in terms of partial derivatives. Existing methods in the literature give us a useful, quantified measure of parameter sensitivity, a first-order effect, but they do not consider second-order effects. Second-order effects could give us additional insights: for example, a first order analysis might tell us that a limiting factor is the efficiency of the vehicle’s prime-mover; our new second order analysis will tell us how quickly the efficiency of the powertrain will become of greater significance. In this paper, we develop a method based on formal optimization mathematics for rapid second-order sensitivity analyses and illustrate these through a case study on a C-segment electric vehicle.

  11. KM3NeT/ARCA sensitivity and discovery potential for neutrino point-like sources

    Directory of Open Access Journals (Sweden)

    Trovato A.

    2016-01-01

    Full Text Available KM3NeT is a large research infrastructure with a network of deep-sea neutrino telescopes in the abyss of the Mediterranean Sea. Of these, the KM3NeT/ARCA detector, installed in the KM3NeT-It node of the network, is optimised for studying high-energy neutrinos of cosmic origin. Sensitivities to galactic sources such as the supernova remnant RXJ1713.7-3946 and the pulsar wind nebula Vela X are presented as well as sensitivities to a generic point source with an E−2 spectrum which represents an approximation for the spectrum of extragalactic candidate neutrino sources.

  12. The necessity for comparative risk analyses as seen from the political point of view

    International Nuclear Information System (INIS)

    Steger, U.

    1981-01-01

    The author describes the current insufficient utilization of risk analyses in the political decision process and investigates if other technologies encounter the same difficulties of acceptance as in the nuclear energy field. This being likely he is trying to find out which contribution comparative risk analyses could make to the process of democratic will-formation so that new technologies are accepted. Firstly the author establishes theses criticizing the recent scientific efforts made in the field of risk analyses and their usability for the political decision process. He then defines the criteria risk analyses have to meet in order to serve as scientific elements for consultative political discussions. (orig./HP) [de

  13. The Extraction of Vegetation Points from LiDAR Using 3D Fractal Dimension Analyses

    Directory of Open Access Journals (Sweden)

    Haiquan Yang

    2015-08-01

    Full Text Available Light Detection and Ranging (LiDAR, a high-precision technique used for acquiring three-dimensional (3D surface information, is widely used to study surface vegetation information. Moreover, the extraction of a vegetation point set from the LiDAR point cloud is a basic starting-point for vegetation information analysis, and an important part of its further processing. To extract the vegetation point set completely and to describe the different spatial morphological characteristics of various features in a LiDAR point cloud, we have used 3D fractal dimensions. We discovered that every feature has its own distinctive 3D fractal dimension interval. Based on the 3D fractal dimensions of tall trees, we propose a new method for the extraction of vegetation using airborne LiDAR. According to this method, target features can be distinguished based on their morphological characteristics. The non-ground points acquired by filtering are processed by region growing segmentation and the morphological characteristics are evaluated by 3D fractal dimensions to determine the features required for the determination of the point set for tall trees. Avon, New York, USA was selected as the study area to test the method and the result proves the method’s efficiency. Thus, this approach is feasible. Additionally, the method uses the 3D coordinate properties of the LiDAR point cloud and does not require additional information, such as return intensity, giving it a larger scope of application.

  14. Mechanical pain sensitivity of deep tissues in children - possible development of myofascial trigger points in children

    Directory of Open Access Journals (Sweden)

    Han Ting-I

    2012-02-01

    Full Text Available Abstract Background It is still unclear when latent myofascial trigger points (MTrPs develop during early life. This study is designed to investigate the mechanical pain sensitivity of deep tissues in children in order to see the possible timing of the development of latent MTrPs and attachment trigger points (A-TrPs in school children. Methods Five hundreds and five healthy school children (age 4- 11 years were investigated. A pressure algometer was used to measure the pressure pain threshold (PPT at three different sites in the brachioradialis muscle: the lateral epicondyle at elbow (site A, assumed to be the A-TrP site, the mid-point of the muscle belly (site B, assumed to be the MTrP site, and the muscle-tendon junction as a control site (site C. Results The results showed that, for all children in this study, the mean PPT values was significantly lower (p p Conclusions It is concluded that a child had increased sensitivity at the tendon attachment site and the muscle belly (endplate zone after age of 4 years. Therefore, it is likely that a child may develop an A-Trp and a latent MTrP at the brachioradialis muscle after the age of 4 years. The changes in sensitivity, or the development for these trigger points, may not be related to the activity level of children aged 7-11 years. Further investigation is still required to indentify the exact timing of the initial occurrence of a-Trps and latent MTrPs.

  15. Sensitivity and specificity of point-of-care rapid combination syphilis-HIV-HCV tests.

    Directory of Open Access Journals (Sweden)

    Kristen L Hess

    Full Text Available New rapid point-of-care (POC tests are being developed that would offer the opportunity to increase screening and treatment of several infections, including syphilis. This study evaluated three of these new rapid POC tests at a site in Southern California.Participants were recruited from a testing center in Long Beach, California. A whole blood specimen was used to evaluate the performance of the Dual Path Platform (DPP Syphilis Screen & Confirm, DPP HIV-Syphilis, and DPP HIV-HCV-Syphilis rapid tests. The gold-standard comparisons were Treponema pallidum passive particle agglutination (TPPA, rapid plasma reagin (RPR, HCV enzyme immunoassay (EIA, and HIV-1/2 EIA.A total of 948 whole blood specimens were analyzed in this study. The sensitivity of the HIV tests ranged from 95.7-100% and the specificity was 99.7-100%. The sensitivity and specificity of the HCV test were 91.8% and 99.3%, respectively. The treponemal-test sensitivity when compared to TPPA ranged from 44.0-52.7% and specificity was 98.7-99.6%. The non-treponemal test sensitivity and specificity when compared to RPR was 47.8% and 98.9%, respectively. The sensitivity of the Screen & Confirm test improved to 90.0% when cases who were both treponemal and nontreponemal positive were compared to TPPA+/RPR ≥ 1 ∶ 8.The HIV and HCV on the multi-infection tests showed good performance, but the treponemal and nontreponemal tests had low sensitivity. These results could be due to a low prevalence of active syphilis in the sample population because the sensitivity improved when the gold standard was limited to those more likely to be active cases. Further evaluation of the new syphilis POC tests is required before implementation into testing programs.

  16. Sensitivity analyses of a global flood model in different geoclimatic regions

    Science.gov (United States)

    Moylan, C.; Neal, J. C.; Freer, J. E.; Pianosi, F.; Wagener, T.; Sampson, C. C.; Smith, A.

    2017-12-01

    Flood models producing global hazard maps now exist, although with significant variation in the modelled hazard extent. Besides explicit structural differences, reasons for this variation is unknown. Understanding the behaviour of these global flood models is necessary to determine how they can be further developed. Preliminary sensitivity analysis was performed using Morris method on the Bristol global flood model, which has 37 parameters, required to translate the remotely sensed data into input for the underlying hydrodynamic model. This number of parameters implies an excess of complexity for flood modelling and should ideally be mitigated. The analysis showed an order of magnitude difference in parameter sensitivities, when comparing total flooded extent. It also showed the most important parameters' influence to be highly interactive rather than just direct; there were surprises in expectation of which parameters are the most important. Despite these findings, conclusions about the model are limited due to the fixed geoclimatic features of the location analysed. Hence more locations with varied geoclimatic characteristics must be chosen, so the consistencies and deviations of parameter sensitivities across these features become quantifiable. Locations are selected using a novel sampling technique, which aggregates the input data of a domain into representative metrics of the geoclimatic features, hypothesised to correlate with one or more parameters. Combinations of these metrics are sampled across a range of geoclimatic areas, and the sensitivities found are correlated with the sampled metrics. From this work, we find the main influences on flood risk prediction at the global scale for the used model structure, which as a methodology is transferable to the other global flood models.

  17. EULAR points to consider when establishing, analysing and reporting safety data of biologics registers in rheumatology

    DEFF Research Database (Denmark)

    Dixon, William G; Carmona, Loreto; Finckh, Axel

    2010-01-01

    upon safety data generated from observational drug registers makes it important to convert the lessons learned from such registers into recommendations for rheumatologists embarking upon the establishment of future registers, or analysing and reporting from new and existing registers.......The introduction of biological therapies for the treatment of rheumatic diseases has drawn attention to the limitations of traditional means of assessing drug safety. Consequently, a series of European academic biologics registers dedicated to this task have been established. Increasing reliance...

  18. Scoping and sensitivity analyses for the Demonstration Tokamak Hybrid Reactor (DTHR)

    International Nuclear Information System (INIS)

    Sink, D.A.; Gibson, G.

    1979-03-01

    The results of an extensive set of parametric studies are presented which provide analytical data of the effects of various tokamak parameters on the performance and cost of the DTHR (Demonstration Tokamak Hybrid Reactor). The studies were centered on a point design which is described in detail. Variations in the device size, neutron wall loading, and plasma aspect ratio are presented, and the effects on direct hardware costs, fissile fuel production (breeding), fusion power production, electrical power consumption, and thermal power production are shown graphically. The studies considered both ignition and beam-driven operations of DTHR and yielded results based on two empirical scaling laws presently used in reactor studies. Sensitivity studies were also made for variations in the following key parameters: the plasma elongation, the minor radius, the TF coil peak field, the neutral beam injection power, and the Z/sub eff/ of the plasma

  19. Hydrophilic property of 316L stainless steel after treatment by atmospheric pressure corona streamer plasma using surface-sensitive analyses

    Energy Technology Data Exchange (ETDEWEB)

    Al-Hamarneh, Ibrahim, E-mail: hamarnehibrahim@yahoo.com [Department of Physics, Faculty of Science, Al-Balqa Applied University, Salt 19117 (Jordan); Pedrow, Patrick [School of Electrical Engineering and Computer Science, Washington State University, Pullman, WA 99164 (United States); Eskhan, Asma; Abu-Lail, Nehal [Gene and Linda Voiland School of Chemical Engineering and Bioengineering, Washington State University, Pullman, WA 99164 (United States)

    2012-10-15

    Highlights: Black-Right-Pointing-Pointer Surface hydrophilic property of surgical-grade 316L stainless steel was enhanced by Ar-O{sub 2} corona streamer plasma treatment. Black-Right-Pointing-Pointer Hydrophilicity, surface morphology, roughness, and chemical composition before and after plasma treatment were evaluated. Black-Right-Pointing-Pointer Contact angle measurements and surface-sensitive analyses techniques, including XPS and AFM, were carried out. Black-Right-Pointing-Pointer Optimum plasma treatment conditions of the SS 316L surface were determined. - Abstract: Surgical-grade 316L stainless steel (SS 316L) had its surface hydrophilic property enhanced by processing in a corona streamer plasma reactor using O{sub 2} gas mixed with Ar at atmospheric pressure. Reactor excitation was 60 Hz ac high-voltage (0-10 kV{sub RMS}) applied to a multi-needle-to-grounded screen electrode configuration. The treated surface was characterized with a contact angle tester. Surface free energy (SFE) for the treated stainless steel increased measurably compared to the untreated surface. The Ar-O{sub 2} plasma was more effective in enhancing the SFE than Ar-only plasma. Optimum conditions for the plasma treatment system used in this study were obtained. X-ray photoelectron spectroscopy (XPS) characterization of the chemical composition of the treated surfaces confirms the existence of new oxygen-containing functional groups contributing to the change in the hydrophilic nature of the surface. These new functional groups were generated by surface reactions caused by reactive oxidation of substrate species. Atomic force microscopy (AFM) images were generated to investigate morphological and roughness changes on the plasma treated surfaces. The aging effect in air after treatment was also studied.

  20. Robust artificial neural network for reliability and sensitivity analyses of complex non-linear systems.

    Science.gov (United States)

    Oparaji, Uchenna; Sheu, Rong-Jiun; Bankhead, Mark; Austin, Jonathan; Patelli, Edoardo

    2017-12-01

    Artificial Neural Networks (ANNs) are commonly used in place of expensive models to reduce the computational burden required for uncertainty quantification, reliability and sensitivity analyses. ANN with selected architecture is trained with the back-propagation algorithm from few data representatives of the input/output relationship of the underlying model of interest. However, different performing ANNs might be obtained with the same training data as a result of the random initialization of the weight parameters in each of the network, leading to an uncertainty in selecting the best performing ANN. On the other hand, using cross-validation to select the best performing ANN based on the ANN with the highest R 2 value can lead to biassing in the prediction. This is as a result of the fact that the use of R 2 cannot determine if the prediction made by ANN is biased. Additionally, R 2 does not indicate if a model is adequate, as it is possible to have a low R 2 for a good model and a high R 2 for a bad model. Hence, in this paper, we propose an approach to improve the robustness of a prediction made by ANN. The approach is based on a systematic combination of identical trained ANNs, by coupling the Bayesian framework and model averaging. Additionally, the uncertainties of the robust prediction derived from the approach are quantified in terms of confidence intervals. To demonstrate the applicability of the proposed approach, two synthetic numerical examples are presented. Finally, the proposed approach is used to perform a reliability and sensitivity analyses on a process simulation model of a UK nuclear effluent treatment plant developed by National Nuclear Laboratory (NNL) and treated in this study as a black-box employing a set of training data as a test case. This model has been extensively validated against plant and experimental data and used to support the UK effluent discharge strategy. Copyright © 2017 Elsevier Ltd. All rights reserved.

  1. Sensitivity Study of Poisson's Ratio Used in Soil Structure Interaction (SSI) Analyses

    Energy Technology Data Exchange (ETDEWEB)

    Han, Seung-ju [KHNP CRI, Daejeon (Korea, Republic of); You, Dong-Hyun [KEPCO Engineering and Construction, Gimcheon (Korea, Republic of); Jang, Jung-bum; Yun, Kwan-hee [KEPCO Research Institute, Daejeon (Korea, Republic of)

    2016-10-15

    The preliminary review for Design Certification (DC) of APR1400 was accepted by NRC on March 4, 2015. After the acceptance of the application for standard DC of APR1400, KHNP has responded the Request for Additional Information (RAI) raised by NRC to undertake a full design certification review. Design certification is achieved through the NRC's rulemaking process, and is founded on the staff's review of the application, which addresses the various safety issues associated with the proposed nuclear power plant design, independent of a specific site. The USNRC issued RAIs pertain to Design Control Document (DCD) Ch.3.7 'Seismic Design' is DCD Tables 3.7A-1 and 3.7A-2 show Poisson’s ratios in the S1 and S2 soil profiles used for SSI analysis as great as 0.47 and 0.48 respectively. Based on staff experience, use of Poisson's ratio approaching these values may result in numerical instability of the SSI analysis results. Sensitivity study is performed using the ACS SASSI NI model of APR1400 with S1 and S2 soil profiles to demonstrate that the Poisson’s ratio values used in the SSI analyses of S1 and S2 soil profile cases do not produce numerical instabilities in the SSI analysis results. No abrupt changes or spurious peaks, which tend to indicate existence of numerical sensitivities in the SASSI solutions, appear in the computed transfer functions of the original SSI analyses that have the maximum dynamic Poisson’s ratio values of 0.47 and 0.48 as well as in the re-computed transfer functions that have the maximum dynamic Poisson’s ratio values limited to 0.42 and 0.45.

  2. Nouveaux instruments de paiement: une analyse du point de vue de la banque centrale

    OpenAIRE

    Li-Chun Yuan

    2003-01-01

    Les évolutions technologiques apportent des solutions de paiement de détail innovantes (paiements par téléphone mobile par exemple). Ce cahier d'études aborde le sujet de la qualification des nouveaux instruments de paiement. Il contient une analyse basée sur la définition des différentes formes de monnaie (dont la monnaie électronique) et des instruments de paiement, dans le cadre général des paiements et des systèmes de paiement, ainsi que dans leur contexte réglementaire national et europé...

  3. [Analyses of coding sequence point mutation and polymorphism of TGFBI gene in Chinese patients with keratoconus].

    Science.gov (United States)

    GUAN, Tao; MA, Zhang-wei; DING, Shi-ping

    2011-04-01

    To investigate the point mutations and polymorphisms of transforming growth factor beta-induced gene (TGFBI) in Chinese patients with keratoconus and discuss the relationship between the feature of gene mutations and single nucleotide polymorphisms of TGFBI gene and keratoconus. Polymerase chain reaction single strand conformation polymorphism and DNA direct sequencing were performed in 30 keratoconus cases and 30 healthy controls. All 17 exons of the TGFBI gene were analyzed for point mutations and single nucleotide polymorphisms. Totally two heterozygous nucleotide changes were identified in exon 12 of the TGFBI gene. The codon 535 is changed from GGA to TGA in 1 patient, leading to a substitution of glycine to a stop codon at the protein level (G535X). The codon 540 is changed from TTT to TTC in 2 patients and 1 control individual, resulting in a nonsense mutation (F54F), and is a single nucleotide polymorphism of the gene. Mutation and polymorphisms of the TGFBI gene were detected in Chinese patients with keratoconus in this study. The results suggest that TGFBI gene might play an important role in the pathogenesis of keratoconus.

  4. Analyses of methyltransferases across the pathogenicity spectrum of different mycobacterial species point to an extremophile connection.

    Science.gov (United States)

    Grover, Sonam; Gupta, Paras; Kahlon, Parvinderdeep S; Goyal, Sukriti; Grover, Abhinav; Dalal, Kuldeep; Sabeeha; Ehtesham, Nasreen Z; Hasnain, Seyed E

    2016-05-26

    Tuberculosis is a devastating disease, taking one human life every 20 seconds globally. We hypothesize that professional pathogens such as M.tb have acquired specific features that might assist in causing infection, persistence and transmissible pathology in their host. We have identified 121 methyltransferases (MTases) in the M.tb proteome, which use a variety of substrates - DNA, RNA, protein, intermediates of mycolic acid biosynthesis and other fatty acids - that are involved in cellular maintenance within the host. A comparative analysis of the proteome of the virulent strain H37Rv and the avirulent strain H37Ra identified 3 MTases, which displayed significant variations in terms of N-terminal extension/deletion and point mutations, possibly impacting various physicochemical properties. The cross-proteomic comparison of MTases of M.tb H37Rv with 15 different Mycobacterium species revealed the acquisition of novel MTases in a MTB complex as a function of evolution. Phylogenetic analysis revealed that these newly acquired MTases showed common roots with certain extremophiles such as halophilic and acidophilic organisms. Our results establish an evolutionary relationship of M.tb with halotolerant organisms and also the role of MTases of M.tb in withstanding the host osmotic stress, thereby pointing to their likely role in pathogenesis, virulence and niche adaptation.

  5. Systematic comparative and sensitivity analyses of additive and outranking techniques for supporting impact significance assessments

    International Nuclear Information System (INIS)

    Cloquell-Ballester, Vicente-Agustin; Monterde-Diaz, Rafael; Cloquell-Ballester, Victor-Andres; Santamarina-Siurana, Maria-Cristina

    2007-01-01

    Assessing the significance of environmental impacts is one of the most important and all together difficult processes of Environmental Impact Assessment. This is largely due to the multicriteria nature of the problem. To date, decision techniques used in the process suffer from two drawbacks, namely the problem of compensation and the problem of identification of the 'exact boundary' between sub-ranges. This article discusses these issues and proposes a methodology for determining the significance of environmental impacts based on comparative and sensitivity analyses using the Electre TRI technique. An application of the methodology for the environmental assessment of a Power Plant project within the Valencian Region (Spain) is presented, and its performance evaluated. It is concluded that contrary to other techniques, Electre TRI automatically identifies those cases where allocation of significance categories is most difficult and, when combined with sensitivity analysis, offers greatest robustness in the face of variation in weights of the significance attributes. Likewise, this research demonstrates the efficacy of systematic comparison between Electre TRI and sum-based techniques, in the solution of assignment problems. The proposed methodology can therefore be regarded as a successful aid to the decision-maker, who will ultimately take the final decision

  6. Analytical sensitivity of four commonly used hCG point of care devices.

    Science.gov (United States)

    Kamer, Sandy M; Foley, Kevin F; Schmidt, Robert L; Greene, Dina N

    2015-04-01

    Point of care (POC) hCG assays are often used to rule-out pregnancy and therefore diagnostic sensitivity, especially at low concentrations of hCG, is important. There are very few studies in the literature that seek to verify the claimed analytical sensitivity of hCG POC devices. The analytical sensitivity of four commonly used hCG POC devices (Alere hCG Combo Cassette, ICON 20 hCG, OSOM hCG Combo Test, and Sure-Vue Serum/Urine hCG-STAT) was challenged using urine samples (n=50) selected based on quantitative hCG concentrations. The majority of these specimens (n=40) had an hCG concentration between 20 and 200 U/L. Each specimen/device combination was reviewed by three individuals. Statistical calculations were performed using Stata 12. The analytical sensitivity of the OSOM was significantly lower inferior than that of the other POC devices. There was no significant difference in the sensitivity of the Alere, ICON 20 and Sure-Vue devices. There was no significant difference in the individual interpretation of the hCG POC results. All hCG POC devices evaluated in this study were susceptible to false negative results at low concentrations of urine hCG. Laboratorians and clinicians should be aware that there are limitations when using urine hCG POC devices to rule out early pregnancy. Copyright © 2014 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

  7. Advances in global sensitivity analyses of demographic-based species distribution models to address uncertainties in dynamic landscapes

    Directory of Open Access Journals (Sweden)

    Ilona Naujokaitis-Lewis

    2016-07-01

    Full Text Available Developing a rigorous understanding of multiple global threats to species persistence requires the use of integrated modeling methods that capture processes which influence species distributions. Species distribution models (SDMs coupled with population dynamics models can incorporate relationships between changing environments and demographics and are increasingly used to quantify relative extinction risks associated with climate and land-use changes. Despite their appeal, uncertainties associated with complex models can undermine their usefulness for advancing predictive ecology and informing conservation management decisions. We developed a computationally-efficient and freely available tool (GRIP 2.0 that implements and automates a global sensitivity analysis of coupled SDM-population dynamics models for comparing the relative influence of demographic parameters and habitat attributes on predicted extinction risk. Advances over previous global sensitivity analyses include the ability to vary habitat suitability across gradients, as well as habitat amount and configuration of spatially-explicit suitability maps of real and simulated landscapes. Using GRIP 2.0, we carried out a multi-model global sensitivity analysis of a coupled SDM-population dynamics model of whitebark pine (Pinus albicaulis in Mount Rainier National Park as a case study and quantified the relative influence of input parameters and their interactions on model predictions. Our results differed from the one-at-time analyses used in the original study, and we found that the most influential parameters included the total amount of suitable habitat within the landscape, survival rates, and effects of a prevalent disease, white pine blister rust. Strong interactions between habitat amount and survival rates of older trees suggests the importance of habitat in mediating the negative influences of white pine blister rust. Our results underscore the importance of considering habitat

  8. Accelerator mass spectrometry analyses of environmental radionuclides: sensitivity, precision and standardisation

    International Nuclear Information System (INIS)

    Hotchkis, Michael; Fink, David; Tuniz, Claudio; Vogt, Stephan

    2000-01-01

    Accelerator Mass Spectrometry (AMS) is the analytical technique of choice for the detection of long-lived radionuclides which cannot be practically analysed with decay counting or conventional mass spectrometry. AMS allows an isotopic sensitivity as low as one part in 10 15 for 14 C (5.73 ka), 10 Be (1.6 Ma), 26 Al (720 ka), 36 Cl (301 ka), 41 Ca (104 ka), 129 I (16 Ma) and other long-lived radionuclides occurring in nature at ultra-trace levels. These radionuclides can be used as tracers and chronometers in many disciplines: geology, archaeology, astrophysics, biomedicine and materials science. Low-level decay counting techniques have been developed in the last 40-50 years to detect the concentration of cosmogenic, radiogenic and anthropogenic radionuclides in a variety of specimens. Radioactivity measurements for long-lived radionuclides are made difficult by low counting rates and in some cases the need for complicated radiochemistry procedures and efficient detectors of soft β-particles and low energy x-rays. The sensitivity of AMS is unaffected by the half-life of the isotope being measured, since the atoms not the radiations that result from their decay, are counted directly. Hence, the efficiency of AMS in the detection of long-lived radionuclides is 10 6 -10 9 times higher than decay counting and the size of the sample required for analysis is reduced accordingly. For example, 14 C is being analysed in samples containing as little as 20 μg carbon. There is also a world-wide effort to use AMS for the analysis of rare nuclides of heavy mass, such as actinides, with important applications in safeguards and nuclear waste disposal. Finally, AMS microprobes are being developed for the in-situ analysis of stable isotopes in geological samples, semiconductors and other materials. Unfortunately, the use of AMS is limited by the expensive accelerator technology required, but there are several attempts to develop compact AMS spectrometers at low (≤0.5 MV) terminal

  9. Incorporating uncertainty of management costs in sensitivity analyses of matrix population models.

    Science.gov (United States)

    Salomon, Yacov; McCarthy, Michael A; Taylor, Peter; Wintle, Brendan A

    2013-02-01

    The importance of accounting for economic costs when making environmental-management decisions subject to resource constraints has been increasingly recognized in recent years. In contrast, uncertainty associated with such costs has often been ignored. We developed a method, on the basis of economic theory, that accounts for the uncertainty in population-management decisions. We considered the case where, rather than taking fixed values, model parameters are random variables that represent the situation when parameters are not precisely known. Hence, the outcome is not precisely known either. Instead of maximizing the expected outcome, we maximized the probability of obtaining an outcome above a threshold of acceptability. We derived explicit analytical expressions for the optimal allocation and its associated probability, as a function of the threshold of acceptability, where the model parameters were distributed according to normal and uniform distributions. To illustrate our approach we revisited a previous study that incorporated cost-efficiency analyses in management decisions that were based on perturbation analyses of matrix population models. Incorporating derivations from this study into our framework, we extended the model to address potential uncertainties. We then applied these results to 2 case studies: management of a Koala (Phascolarctos cinereus) population and conservation of an olive ridley sea turtle (Lepidochelys olivacea) population. For low aspirations, that is, when the threshold of acceptability is relatively low, the optimal strategy was obtained by diversifying the allocation of funds. Conversely, for high aspirations, the budget was directed toward management actions with the highest potential effect on the population. The exact optimal allocation was sensitive to the choice of uncertainty model. Our results highlight the importance of accounting for uncertainty when making decisions and suggest that more effort should be placed on

  10. Sensitivity analyses of seismic behavior of spent fuel dry cask storage systems

    International Nuclear Information System (INIS)

    Luk, V.K.; Spencer, B.W.; Shaukat, S.K.; Lam, I.P.; Dameron, R.A.

    2003-01-01

    Sandia National Laboratories is conducting a research project to develop a comprehensive methodology for evaluating the seismic behavior of spent fuel dry cask storage systems (DCSS) for the Office of Nuclear Regulatory Research of the U.S. Nuclear Regulatory Commission (NRC). A typical Independent Spent Fuel Storage Installation (ISFSI) consists of arrays of free-standing storage casks resting on concrete pads. In the safety review process of these cask systems, their seismically induced horizontal displacements and angular rotations must be quantified to determine whether casks will overturn or neighboring casks will collide during a seismic event. The ABAQUS/Explicit code is used to analyze three-dimensional coupled finite element models consisting of three submodels, which are a cylindrical cask or a rectangular module, a flexible concrete pad, and an underlying soil foundation. The coupled model includes two sets of contact surfaces between the submodels with prescribed coefficients of friction. The seismic event is described by one vertical and two horizontal components of statistically independent seismic acceleration time histories. A deconvolution procedure is used to adjust the amplitudes and frequency contents of these three-component reference surface motions before applying them simultaneously at the soil foundation base. The research project focused on examining the dynamic and nonlinear seismic behavior of the coupled model of free-standing DCSS including soil-structure interaction effects. This paper presents a subset of analysis results for a series of parametric analyses. Input variables in the parametric analyses include: designs of the cask/module, time histories of the seismic accelerations, coefficients of friction at the cask/pad interface, and material properties of the soil foundation. In subsequent research, the analysis results will be compiled and presented in nomograms to highlight the sensitivity of seismic response of DCSS to

  11. Demonstrating the efficiency of the EFPC criterion by means of Sensitivity analyses

    Energy Technology Data Exchange (ETDEWEB)

    Munier, Raymond

    2007-04-15

    Within the framework of a project to characterise large fractures, a modelling effort was initiated to evaluate the use of a pair of full perimeter criteria, FPC and EFPC, for detecting fractures that could jeopardize the integrity of the canisters in the case of a large nearby earthquake. Though some sensitivity studies were performed in the method study of these mainly targeted aspects of Monte-Carlo simulations. The impact of uncertainties in the DFN model upon the efficiency of the FPI criteria was left unattended. The main purpose of this report is, therefore, to explore the impact of DFN variability upon the efficiency of the FPI criteria. The outcome of the present report may thus be regarded as complementary analyses to the ones presented in SKB-R-06-54. To appreciate the details of the present report, the reader should be acquainted with the simulation procedure described the earlier report. The most important conclusion of this study is that the efficiency of the EFPC is high for all tested model variants. That is, compared to blind deposition, the EFPC is a very powerful tool to identify unsuitable deposition holes and it is essentially insensitive to variations in the DFN Model. If information from adjacent tunnels is used in addition to EFPC, then the probability of detecting a critical deposition hole is almost 100%.

  12. Evaluation of a new handheld point-of-care blood gas analyser using 100 equine blood samples.

    Science.gov (United States)

    Bardell, David; West, Eleanor; Mark Senior, J

    2017-02-22

    To determine whether the Enterprise point-of-care blood analysis system (EPOC) produces results in agreement with two other blood gas analysers in regular clinical use (i-STAT and Radiometer ABL77) and to investigate the precision of the new machine when used with equine whole blood. Prospective, randomized, non-blinded, comparative laboratory analyser study. Horses admitted to a university teaching hospital requiring arterial or venous blood gas analysis as part of their routine clinical management. One hundred equine blood samples were run immediately, consecutively and in randomized order on three blood gas analysers. Results of variables common to all three analysers were tested for agreement and compared with guidelines used in human medicine. These require 80% of results from the test analyser to fall within a defined range or percentage of results from the comparator devices to achieve acceptability. Additionally, 21 samples were run twice in quick succession on the EPOC analyser to investigate precision. Agreement targets were not met for haematocrit, haemoglobin and base excess for either i-STAT or ABL77 analysers. EPOC precision targets were not met for partial pressure of carbon dioxide, ionized calcium, haematocrit and haemoglobin. Overall comparative performance of the EPOC was good to excellent for pH, oxygen tension, potassium, bicarbonate and oxygen saturation of haemoglobin, but marginal to poor for other parameters. The EPOC may be useful in performing analysis of equine whole blood, but trend analysis of carbon dioxide tension, ionized calcium, haematocrit and haemoglobin should be interpreted with caution. The EPOC should not be used interchangeably with other blood gas analysers. Copyright © 2016 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia. Published by Elsevier Ltd. All rights reserved.

  13. Defining optimal DEM resolutions and point densities for modelling hydrologically sensitive areas in agricultural catchments dominated by microtopography

    Science.gov (United States)

    Thomas, I. A.; Jordan, P.; Shine, O.; Fenton, O.; Mellander, P.-E.; Dunlop, P.; Murphy, P. N. C.

    2017-02-01

    Defining critical source areas (CSAs) of diffuse pollution in agricultural catchments depends upon the accurate delineation of hydrologically sensitive areas (HSAs) at highest risk of generating surface runoff pathways. In topographically complex landscapes, this delineation is constrained by digital elevation model (DEM) resolution and the influence of microtopographic features. To address this, optimal DEM resolutions and point densities for spatially modelling HSAs were investigated, for onward use in delineating CSAs. The surface runoff framework was modelled using the Topographic Wetness Index (TWI) and maps were derived from 0.25 m LiDAR DEMs (40 bare-earth points m-2), resampled 1 m and 2 m LiDAR DEMs, and a radar generated 5 m DEM. Furthermore, the resampled 1 m and 2 m LiDAR DEMs were regenerated with reduced bare-earth point densities (5, 2, 1, 0.5, 0.25 and 0.125 points m-2) to analyse effects on elevation accuracy and important microtopographic features. Results were compared to surface runoff field observations in two 10 km2 agricultural catchments for evaluation. Analysis showed that the accuracy of modelled HSAs using different thresholds (5%, 10% and 15% of the catchment area with the highest TWI values) was much higher using LiDAR data compared to the 5 m DEM (70-100% and 10-84%, respectively). This was attributed to the DEM capturing microtopographic features such as hedgerow banks, roads, tramlines and open agricultural drains, which acted as topographic barriers or channels that diverted runoff away from the hillslope scale flow direction. Furthermore, the identification of 'breakthrough' and 'delivery' points along runoff pathways where runoff and mobilised pollutants could be potentially transported between fields or delivered to the drainage channel network was much higher using LiDAR data compared to the 5 m DEM (75-100% and 0-100%, respectively). Optimal DEM resolutions of 1-2 m were identified for modelling HSAs, which balanced the need

  14. Point processes statistics of stable isotopes: analysing water uptake patterns in a mixed stand of Aleppo pine and Holm oak

    Directory of Open Access Journals (Sweden)

    Carles Comas

    2015-04-01

    Full Text Available Aim of study: Understanding inter- and intra-specific competition for water is crucial in drought-prone environments. However, little is known about the spatial interdependencies for water uptake among individuals in mixed stands. The aim of this work was to compare water uptake patterns during a drought episode in two common Mediterranean tree species, Quercus ilex L. and Pinus halepensis Mill., using the isotope composition of xylem water (δ18O, δ2H as hydrological marker. Area of study: The study was performed in a mixed stand, sampling a total of 33 oaks and 78 pines (plot area= 888 m2. We tested the hypothesis that both species uptake water differentially along the soil profile, thus showing different levels of tree-to-tree interdependency, depending on whether neighbouring trees belong to one species or the other. Material and Methods: We used pair-correlation functions to study intra-specific point-tree configurations and the bivariate pair correlation function to analyse the inter-specific spatial configuration. Moreover, the isotopic composition of xylem water was analysed as a mark point pattern. Main results: Values for Q. ilex (δ18O = –5.3 ± 0.2‰, δ2H = –54.3 ± 0.7‰ were significantly lower than for P. halepensis (δ18O = –1.2 ± 0.2‰, δ2H = –25.1 ± 0.8‰, pointing to a greater contribution of deeper soil layers for water uptake by Q. ilex. Research highlights: Point-process analyses revealed spatial intra-specific dependencies among neighbouring pines, showing neither oak-oak nor oak-pine interactions. This supports niche segregation for water uptake between the two species.

  15. Sustained nociceptive mechanical stimulation of latent myofascial trigger point induces central sensitization in healthy subjects.

    Science.gov (United States)

    Xu, Yi-Meng; Ge, Hong-You; Arendt-Nielsen, Lars

    2010-12-01

    The aim of the study is to test if sustained nociceptive mechanical stimulation (SNMS) of latent myofascial trigger points (MTrPs) induces widespread mechanical hyperalgesia. SNMS was obtained by inserting and retaining an intramuscular electromyographic (EMG) needle within a latent MTrP or a nonMTrP in the finger extensor muscle for 8 minutes in 12 healthy subjects. Pain intensity (VAS) and referred pain area induced by SNMS were recorded. Pressure pain threshold (PPT) was measured immediately before and after, and 10-, 20-, and 30-minutes after SNMS at the midpoint of the contralateral tibialis anterior muscle. Surface and intramuscular EMG during SNMS were recorded. When compared to nonMTrPs, maximal VAS and the area under VAS curve (VASauc) were significantly higher and larger during SNMS of latent MTrPs (both, P induction of local and referred pain. This study shows that MTrPs are one of the important peripheral pain generators and initiators for central sensitization. Therapeutic methods for decreasing the sensitivity and motor-unit excitability of MTrPs may prevent the development of muscle cramps and thus decrease local and referred pain. Copyright © 2010 American Pain Society. Published by Elsevier Inc. All rights reserved.

  16. Improved LFIAs for highly sensitive detection of BNP at point-of-care.

    Science.gov (United States)

    Gong, Yan; Hu, Jie; Choi, Jane Ru; You, Minli; Zheng, Yamin; Xu, Bo; Wen, Ting; Xu, Feng

    2017-01-01

    Heart failure (HF) has become a major cause of morbidity and mortality with a significant global economic burden. Although well-established clinical tests could provide early diagnosis, access to these tests is limited in developing countries, where a relatively higher incidence of HF is present. This has prompted an urgent need for developing a cost-effective, rapid and robust diagnostic tool for point-of-care (POC) detection of HF. Lateral flow immunoassay (LFIA) has found widespread applications in POC diagnostics. However, the low sensitivity of LFIA limits its ability to detect important HF biomarkers (e.g., brain natriuretic peptide [BNP]) that are normally present in low concentration in blood. To address this issue, we developed an improved LFIA by optimizing the gold nanoparticle (GNP)-antibody conjugate conditions (e.g., the conjugate pH and the amount of added antibody), the diameter of GNP and the concentration of antibody embedded on the test line and modifying the structure of test strip. Through these improvements, the proposed test strip enabled the detection of BNP down to 0.1 ng/mL within 10-15 min, presenting ~15-fold sensitivity enhancement over conventional lateral flow assay. We also successfully applied our LFIA in the analysis of BNP in human serum samples, highlighting its potential use for clinical assessment of HF. The developed LFIA for BNP could rapidly rule out HF with the naked eye, offering tremendous potential for POC test and personalized medicine.

  17. Muscle Trigger Points and Pressure Pain Sensitivity Maps of the Feet in Women with Fibromyalgia Syndrome.

    Science.gov (United States)

    Tornero-Caballero, Maria C; Salom-Moreno, Jaime; Cigarán-Méndez, Margarita; Morales-Cabezas, Matilde; Madeleine, Pascal; Fernández-de-Las-Peñas, César

    2016-10-01

    OBJECTIVE : To investigate the presence of trigger points (TrPs) in feet musculature and topographical pressure sensitivity maps of the feet as well as the relationship between TrPs, pressure pain maps, and clinical variables in women with fibromyalgia (FMS). METHODS : Fifty-one FMS women and 24 comparable healthy women participated. TrPs within the flexor hallucis brevis, adductor hallucis, dorsal interossei, extensor digitorum brevis, and quadratus plantae, as well as external and internal gastrocnemius, were explored. Pressure pain thresholds (PPTs) were assessed in a blind manner over seven locations on each foot. Topographical pressure sensitivity maps of the plantar region were generated using the averaged PPT of each location. RESULTS : The prevalence rate of foot pain was 63% (n = 32). The number of active TrPs for each FMS woman with foot pain was 5 ± 1.5 without any latent TrPs. Women with FMS without foot pain and healthy controls had only latent TrPs (2.2 ± 0.8 and 1.5 ± 1.3, respectively). Active TrPs in the flexor hallucis brevis and adductor hallucis muscles were the most prevalent. Topographical pressure pain sensitivity maps revealed that FMS women with foot pain had lower PPT than FMS women without pain and healthy controls, and higher PPT on the calcaneus bone (P pain in women with FMS is high. The referred pain elicited by active TrPs in the foot muscles reproduced the symptoms in these patients. FMS women suffering foot pain showed higher pressure hypersensitivity in the plantar region than those FMS women without pain. © 2016 American Academy of Pain Medicine. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  18. Sensitivity of Coastal Environments and Wildlife to Spilled Oil: Northwest Arctic, Alaska: M_MAMPT (Marine Mammal Points)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains sensitive biological resource data for Steller sea lions and polar bears in Northwest Arctic, Alaska. Vector points in this data set represent...

  19. High sensitivity point-of-care device for direct virus diagnostics

    DEFF Research Database (Denmark)

    Kiilerich-Pedersen, Katrine; Dapra, Johannes; Cherré, Solène

    2013-01-01

    Influenza infections are associated with high morbidity and mortality, carry the risk of pandemics, and pose a considerable economic burden worldwide. To improve the management of the illness, it is essential with accurate and fast point-of-care diagnostic tools for use in the field or at the pat......Influenza infections are associated with high morbidity and mortality, carry the risk of pandemics, and pose a considerable economic burden worldwide. To improve the management of the illness, it is essential with accurate and fast point-of-care diagnostic tools for use in the field...... or at the patient's bedside. Conventional diagnostic methods are time consuming, expensive and require specialized laboratory facilities. We present a highly sensitive, highly specific, and low cost platform to test for acute virus infections in less than 15. min, employing influenza A virus (H1N1) as an example...... of its usability. An all polymer microfluidic system with a functionalized conductive polymer (PEDOT-OH:TsO) microelectrode array was developed and exploited for label free and real time electrochemical detection of intact influenza A virus (H1N1) particles. DNA aptamers with affinity for influenza...

  20. Analyses of single nucleotide polymorphisms in selected nutrient-sensitive genes in weight-regain prevention

    DEFF Research Database (Denmark)

    Larsen, Lesli Hingstrup; Ängquist, Lars Henrik; Vimaleswaran, Karani S

    2012-01-01

    Differences in the interindividual response to dietary intervention could be modified by genetic variation in nutrient-sensitive genes.......Differences in the interindividual response to dietary intervention could be modified by genetic variation in nutrient-sensitive genes....

  1. Parameterization and sensitivity analyses of a radiative transfer model for remote sensing plant canopies

    Science.gov (United States)

    Hall, Carlton Raden

    A major objective of remote sensing is determination of biochemical and biophysical characteristics of plant canopies utilizing high spectral resolution sensors. Canopy reflectance signatures are dependent on absorption and scattering processes of the leaf, canopy properties, and the ground beneath the canopy. This research investigates, through field and laboratory data collection, and computer model parameterization and simulations, the relationships between leaf optical properties, canopy biophysical features, and the nadir viewed above-canopy reflectance signature. Emphasis is placed on parameterization and application of an existing irradiance radiative transfer model developed for aquatic systems. Data and model analyses provide knowledge on the relative importance of leaves and canopy biophysical features in estimating the diffuse absorption a(lambda,m-1), diffuse backscatter b(lambda,m-1), beam attenuation alpha(lambda,m-1), and beam to diffuse conversion c(lambda,m-1 ) coefficients of the two-flow irradiance model. Data sets include field and laboratory measurements from three plant species, live oak (Quercus virginiana), Brazilian pepper (Schinus terebinthifolius) and grapefruit (Citrus paradisi) sampled on Cape Canaveral Air Force Station and Kennedy Space Center Florida in March and April of 1997. Features measured were depth h (m), projected foliage coverage PFC, leaf area index LAI, and zenith leaf angle. Optical measurements, collected with a Spectron SE 590 high sensitivity narrow bandwidth spectrograph, included above canopy reflectance, internal canopy transmittance and reflectance and bottom reflectance. Leaf samples were returned to laboratory where optical and physical and chemical measurements of leaf thickness, leaf area, leaf moisture and pigment content were made. A new term, the leaf volume correction index LVCI was developed and demonstrated in support of model coefficient parameterization. The LVCI is based on angle adjusted leaf

  2. Sensitivity analyses of OH missing sinks over Tokyo metropolitan area in the summer of 2007

    Directory of Open Access Journals (Sweden)

    K. Ishii

    2009-11-01

    Full Text Available OH reactivity is one of key indicators which reflect impacts of photochemical reactions in the atmosphere. An observation campaign has been conducted in the summer of 2007 at the heart of Tokyo metropolitan area to measure OH reactivity. The total OH reactivity measured directly by the laser-induced pump and probe technique was higher than the sum of the OH reactivity calculated from concentrations and reaction rate coefficients of individual species measured in this campaign. And then, three-dimensional air quality simulation has been conducted to evaluate the simulation performance on the total OH reactivity including "missing sinks", which correspond to the difference between the measured and calculated total OH reactivity. The simulated OH reactivity is significantly underestimated because the OH reactivity of volatile organic compounds (VOCs and missing sinks are underestimated. When scaling factors are applied to input emissions and boundary concentrations, a good agreement is observed between the simulated and measured concentrations of VOCs. However, the simulated OH reactivity of missing sinks is still underestimated. Therefore, impacts of unidentified missing sinks are investigated through sensitivity analyses. In the cases that unknown secondary products are assumed to account for unidentified missing sinks, they tend to suppress formation of secondary aerosol components and enhance formation of ozone. In the cases that unidentified primary emitted species are assumed to account for unidentified missing sinks, a variety of impacts may be observed, which could serve as precursors of secondary organic aerosols (SOA and significantly increase SOA formation. Missing sinks are considered to play an important role in the atmosphere over Tokyo metropolitan area.

  3. Contributions to sensitivity analysis and generalized discriminant analysis; Contributions a l'analyse de sensibilite et a l'analyse discriminante generalisee

    Energy Technology Data Exchange (ETDEWEB)

    Jacques, J

    2005-12-15

    Two topics are studied in this thesis: sensitivity analysis and generalized discriminant analysis. Global sensitivity analysis of a mathematical model studies how the output variables of this last react to variations of its inputs. The methods based on the study of the variance quantify the part of variance of the response of the model due to each input variable and each subset of input variables. The first subject of this thesis is the impact of a model uncertainty on results of a sensitivity analysis. Two particular forms of uncertainty are studied: that due to a change of the model of reference, and that due to the use of a simplified model with the place of the model of reference. A second problem was studied during this thesis, that of models with correlated inputs. Indeed, classical sensitivity indices not having significance (from an interpretation point of view) in the presence of correlation of the inputs, we propose a multidimensional approach consisting in expressing the sensitivity of the output of the model to groups of correlated variables. Applications in the field of nuclear engineering illustrate this work. Generalized discriminant analysis consists in classifying the individuals of a test sample in groups, by using information contained in a training sample, when these two samples do not come from the same population. This work extends existing methods in a Gaussian context to the case of binary data. An application in public health illustrates the utility of generalized discrimination models thus defined. (author)

  4. Neuro Emotional Technique for the treatment of trigger point sensitivity in chronic neck pain sufferers: A controlled clinical trial

    OpenAIRE

    Bablis, Peter; Pollard, Henry; Bonello, Rod

    2008-01-01

    Abstract Background Trigger points have been shown to be active in many myofascial pain syndromes. Treatment of trigger point pain and dysfunction may be explained through the mechanisms of central and peripheral paradigms. This study aimed to investigate whether the mind/body treatment of Neuro Emotional Technique (NET) could significantly relieve pain sensitivity of trigger points presenting in a cohort of chronic neck pain sufferers. Methods Sixty participants presenting to a private chiro...

  5. An improved lake model for climate simulations: Model structure, evaluation, and sensitivity analyses in CESM1

    Directory of Open Access Journals (Sweden)

    Zachary Subin

    2012-02-01

    Full Text Available Lakes can influence regional climate, yet most general circulation models have, at best, simple and largely untested representations of lakes. We developed the Lake, Ice, Snow, and Sediment Simulator(LISSS for inclusion in the land-surface component (CLM4 of an earth system model (CESM1. The existing CLM4 lake modelperformed poorly at all sites tested; for temperate lakes, summer surface water temperature predictions were 10–25uC lower than observations. CLM4-LISSS modifies the existing model by including (1 a treatment of snow; (2 freezing, melting, and ice physics; (3 a sediment thermal submodel; (4 spatially variable prescribed lakedepth; (5 improved parameterizations of lake surface properties; (6 increased mixing under ice and in deep lakes; and (7 correction of previous errors. We evaluated the lake model predictions of water temperature and surface fluxes at three small temperate and boreal lakes where extensive observational data was available. We alsoevaluated the predicted water temperature and/or ice and snow thicknesses for ten other lakes where less comprehensive forcing observations were available. CLM4-LISSS performed very well compared to observations for shallow to medium-depth small lakes. For large, deep lakes, the under-prediction of mixing was improved by increasing the lake eddy diffusivity by a factor of 10, consistent with previouspublished analyses. Surface temperature and surface flux predictions were improved when the aerodynamic roughness lengths were calculated as a function of friction velocity, rather than using a constant value of 1 mm or greater. We evaluated the sensitivity of surface energy fluxes to modeled lake processes and parameters. Largechanges in monthly-averaged surface fluxes (up to 30 W m22 were found when excluding snow insulation or phase change physics and when varying the opacity, depth, albedo of melting lake ice, and mixing strength across ranges commonly found in real lakes. Typical

  6. Xenon-131 surface sensitive imaging of aerogels in liquid xenon near the critical point.

    Science.gov (United States)

    Pavlovskaya, G; Blue, A K; Gibbs, S J; Haake, M; Cros, F; Malier, L; Meersmann, T

    1999-03-01

    In recent years, optically pumped xenon-129 has received a great deal of attention as a contrast agent in gas-phase imaging. This report is about the other NMR active xenon isotope (i.e., xenon-131, S = 32) which exhibits distinctive features for imaging applications in material sciences that are not obtainable from xenon-129 (S = (1/2)). The spin dynamics of xenon-131 in gas and liquid phases is largely determined by quadrupolar interactions which depend strongly on the surface of the surrounding materials. This leads to a surface dependent dispersion of relaxation rates, which can be substantial for this isotope. The dephasing of the coherence due to quadrupolar interactions may be used to yield surface specific contrast for imaging. Although optical pumping is not practical for this isotope because of its fast quadrupolar relaxation, a high spin density of liquid xenon close to the critical point (289 K) overcomes the sensitivity problems of xenon-131. We report the first xenon-131 magnetic resonance images and have tested this technique on various meso-porous aerogels as host structures. Aerogels of different densities and changing levels of hydration can clearly be distinguished from the images obtained. Copyright 1999 Academic Press.

  7. Point-of-care detection of extracellular vesicles: Sensitivity optimization and multiple-target detection.

    Science.gov (United States)

    Oliveira-Rodríguez, Myriam; Serrano-Pertierra, Esther; García, Agustín Costa; López-Martín, Soraya; Yañez-Mo, María; Cernuda-Morollón, Eva; Blanco-López, M C

    2017-01-15

    Extracellular vesicles (EVs) are membrane-bound nanovesicles delivered by different cellular lineages under physiological and pathological conditions. Although these vesicles have shown relevance as biomarkers for a number of diseases, their isolation and detection still has several technical drawbacks, mainly related with problems of sensitivity and time-consumed. Here, we reported a rapid and multiple-targeted lateral flow immunoassay (LFIA) system for the detection of EVs isolated from human plasma. A range of different labels (colloidal gold, carbon black and magnetic nanoparticles) was compared as detection probe in LFIA, being gold nanoparticles that showed better results. Using this platform, we demonstrated that improvements may be carried out by incorporating additional capture lines with different antibodies. The device exhibited a limit of detection (LOD) of 3.4×10 6 EVs/µL when anti-CD81 and anti-CD9 were selected as capture antibodies in a multiple-targeted format, and anti-CD63 labeled with gold nanoparticles was used as detection probe. This LFIA, coupled to EVs isolation kits, could become a rapid and useful tool for the point-of-care detection of EVs, with a total analysis time of two hours. Copyright © 2016 Elsevier B.V. All rights reserved.

  8. Sensitivity of the direct stop pair production analyses in phenomenological MSSM simplified models with the ATLAS detectors

    CERN Document Server

    Snyder, Ian Michael; The ATLAS collaboration

    2018-01-01

    The sensitivity of the searches for the direct pair production of stops often has been evaluated in simple SUSY scenarios, where only a limited set of supersymmetric particles take part to the stop decay. In this talk, the interpretations of the analyses requiring zero, one or two leptons in the final states to simple but well motivated MSSM scenarios will be discussed.

  9. Evidence of Territoriality and Species Interactions from Spatial Point-Pattern Analyses of Subarctic-Nesting Geese

    Science.gov (United States)

    Reiter, Matthew E.; Andersen, David E.

    2013-01-01

    Quantifying spatial patterns of bird nests and nest fate provides insights into processes influencing a species’ distribution. At Cape Churchill, Manitoba, Canada, recent declines in breeding Eastern Prairie Population Canada geese (Branta canadensis interior) has coincided with increasing populations of nesting lesser snow geese (Chen caerulescens caerulescens) and Ross’s geese (Chen rossii). We conducted a spatial analysis of point patterns using Canada goose nest locations and nest fate, and lesser snow goose nest locations at two study areas in northern Manitoba with different densities and temporal durations of sympatric nesting Canada and lesser snow geese. Specifically, we assessed (1) whether Canada geese exhibited territoriality and at what scale and nest density; and (2) whether spatial patterns of Canada goose nest fate were associated with the density of nesting lesser snow geese as predicted by the protective-association hypothesis. Between 2001 and 2007, our data suggest that Canada geese were territorial at the scale of nearest neighbors, but were aggregated when considering overall density of conspecifics at slightly broader spatial scales. The spatial distribution of nest fates indicated that lesser snow goose nest proximity and density likely influence Canada goose nest fate. Our analyses of spatial point patterns suggested that continued changes in the distribution and abundance of breeding lesser snow geese on the Hudson Bay Lowlands may have impacts on the reproductive performance of Canada geese, and subsequently the spatial distribution of Canada goose nests. PMID:24312520

  10. High-sensitivity detection of cardiac troponin I with UV LED excitation for use in point-of-care immunoassay

    OpenAIRE

    Rodenko, Olga; Eriksson, Susann; Tidemand-Lichtenberg, Peter; Troldborg, Carl Peder; Fodgaard, Henrik; van Os, Sylvana; Pedersen, Christian

    2017-01-01

    High-sensitivity cardiac troponin assay development enables determination of biological variation in healthy populations, more accurate interpretation of clinical results and points towards earlier diagnosis and rule-out of acute myocardial infarction. In this paper, we report on preliminary tests of an immunoassay analyzer employing an optimized LED excitation to measure on a standard troponin I and a novel research high-sensitivity troponin I assay. The limit of detection is improved by fac...

  11. Criticality safety and sensitivity analyses of PWR spent nuclear fuel repository facilities

    NARCIS (Netherlands)

    Maucec, M; Glumac, B

    Monte Carlo criticality safety and sensitivity calculations of pressurized water reactor (PWR) spent nuclear fuel repository facilities for the Slovenian nuclear power plant Krsko are presented. The MCNP4C code was deployed to model and assess the neutron multiplication parameters of pool-based

  12. Sensitivity analyses of biodiesel thermo-physical properties under diesel engine conditions

    DEFF Research Database (Denmark)

    Cheng, Xinwei; Ng, Hoon Kiat; Gan, Suyin

    2016-01-01

    This reported work investigates the sensitivities of spray and soot developments to the change of thermo-physical properties for coconut and soybean methyl esters, using two-dimensional computational fluid dynamics fuel spray modelling. The choice of test fuels made was due to their contrasting s...

  13. Tests of methods and software for set-valued model calibration and sensitivity analyses

    NARCIS (Netherlands)

    Janssen PHM; Sanders R; CWM

    1995-01-01

    Testen worden besproken die zijn uitgevoerd op methoden en software voor calibratie middels 'rotated-random-scanning', en voor gevoeligheidsanalyse op basis van de 'dominant direction analysis' en de 'generalized sensitivity analysis'. Deze technieken werden

  14. Genome-wide functional genomic and transcriptomic analyses for genes regulating sensitivity to vorinostat.

    Science.gov (United States)

    Falkenberg, Katrina J; Gould, Cathryn M; Johnstone, Ricky W; Simpson, Kaylene J

    2014-01-01

    Identification of mechanisms of resistance to histone deacetylase inhibitors, such as vorinostat, is important in order to utilise these anticancer compounds more efficiently in the clinic. Here, we present a dataset containing multiple tiers of stringent siRNA screening for genes that when knocked down conferred sensitivity to vorinostat-induced cell death. We also present data from a miRNA overexpression screen for miRNAs contributing to vorinostat sensitivity. Furthermore, we provide transcriptomic analysis using massively parallel sequencing upon knockdown of 14 validated vorinostat-resistance genes. These datasets are suitable for analysis of genes and miRNAs involved in cell death in the presence and absence of vorinostat as well as computational biology approaches to identify gene regulatory networks.

  15. Using ambulatory care sensitive hospitalisations to analyse the effectiveness of primary care services in Mexico.

    OpenAIRE

    Lugo-Palacios, DG; Cairns, J

    2015-01-01

    Ambulatory care sensitive hospitalisations (ACSH) have been widely used to study the quality and effectiveness of primary care. Using data from 248 general hospitals in Mexico during 2001-2011 we identify 926,769 ACSHs in 188 health jurisdictions before and during the health insurance expansion that took place in this period, and estimate a fixed effects model to explain the association of the jurisdiction ACSH rate with patient and community factors. National ACSH rate increased by 50%, but ...

  16. Specific binding of 125I-labeled human chorionic gonadotropin to gonadal tissue: comparison of limited-point saturation analyses to Scatchard analyses for determining binding capacities and factors affecting estimates of binding capacity

    International Nuclear Information System (INIS)

    Spicer, L.J.; Ireland, J.J.

    1986-01-01

    Experiments were conducted to compare gonadotropin binding capacity calculated from limited-point saturation analyses to those obtained from Scatchard analyses, and to test the effects of membrane purity and source of gonadotropin receptors on determining the maximum percentage of radioiodinated hormone bound to receptors (maximum bindability). One- to four-point saturation analyses gave results comparable to results by Scatchard analyses when examining relative binding capacities of receptors. Crude testicular homogenates had lower estimates of maximum bindability of 125 I-labeled human chorionic gonadotropin than more purified gonadotropin receptor preparations. Under similar preparation techniques, some gonadotropin receptor sources exhibited low maximum bindability

  17. Pre-waste-emplacement ground-water travel time sensitivity and uncertainty analyses for Yucca Mountain, Nevada

    International Nuclear Information System (INIS)

    Kaplan, P.G.

    1993-01-01

    Yucca Mountain, Nevada is a potential site for a high-level radioactive-waste repository. Uncertainty and sensitivity analyses were performed to estimate critical factors in the performance of the site with respect to a criterion in terms of pre-waste-emplacement ground-water travel time. The degree of failure in the analytical model to meet the criterion is sensitive to the estimate of fracture porosity in the upper welded unit of the problem domain. Fracture porosity is derived from a number of more fundamental measurements including fracture frequency, fracture orientation, and the moisture-retention characteristic inferred for the fracture domain

  18. An approach of sensitivity and uncertainty analyses methods installation in a safety calculation

    International Nuclear Information System (INIS)

    Pepin, G.; Sallaberry, C.

    2003-01-01

    Simulation of the migration in deep geological formations leads to solve convection-diffusion equations in porous media, associated with the computation of hydrogeologic flow. Different time-scales (simulation during 1 million years), scales of space, contrasts of properties in the calculation domain, are taken into account. This document deals more particularly with uncertainties on the input data of the model. These uncertainties are taken into account in total analysis with the use of uncertainty and sensitivity analysis. ANDRA (French national agency for the management of radioactive wastes) carries out studies on the treatment of input data uncertainties and their propagation in the models of safety, in order to be able to quantify the influence of input data uncertainties of the models on the various indicators of safety selected. The step taken by ANDRA consists initially of 2 studies undertaken in parallel: - the first consists of an international review of the choices retained by ANDRA foreign counterparts to carry out their uncertainty and sensitivity analysis, - the second relates to a review of the various methods being able to be used in sensitivity and uncertainty analysis in the context of ANDRA's safety calculations. Then, these studies are supplemented by a comparison of the principal methods on a test case which gathers all the specific constraints (physical, numerical and data-processing) of the problem studied by ANDRA

  19. Response surfaces and sensitivity analyses for an environmental model of dose calculations

    International Nuclear Information System (INIS)

    Iooss, Bertrand; Van Dorpe, Francois; Devictor, Nicolas

    2006-01-01

    A parametric sensitivity analysis is carried out on GASCON, a radiological impact software describing the radionuclides transfer to the man following a chronic gas release of a nuclear facility. An effective dose received by age group can thus be calculated according to a specific radionuclide and to the duration of the release. In this study, we are concerned by 18 output variables, each depending of approximately 50 uncertain input parameters. First, the generation of 1000 Monte-Carlo simulations allows us to calculate correlation coefficients between input parameters and output variables, which give a first overview of important factors. Response surfaces are then constructed in polynomial form, and used to predict system responses at reduced computation time cost; this response surface will be very useful for global sensitivity analysis where thousands of runs are required. Using the response surfaces, we calculate the total sensitivity indices of Sobol by the Monte-Carlo method. We demonstrate the application of this method to one site of study and to one reference group near the nuclear research Center of Cadarache (France), for two radionuclides: iodine 129 and uranium 238. It is thus shown that the most influential parameters are all related to the food chain of the goat's milk, in decreasing order of importance: dose coefficient 'effective ingestion', goat's milk ration of the individuals of the reference group, grass ration of the goat, dry deposition velocity and transfer factor to the goat's milk

  20. High-sensitivity detection of cardiac troponin I with UV LED excitation for use in point-of-care immunoassay

    DEFF Research Database (Denmark)

    Rodenko, Olga; Eriksson, Susann; Tidemand-Lichtenberg, Peter

    2017-01-01

    High-sensitivity cardiac troponin assay development enables determination of biological variation in healthy populations, more accurate interpretation of clinical results and points towards earlier diagnosis and rule-out of acute myocardial infarction. In this paper, we report on preliminary test...

  1. Sensitivity and specificity of a rapid point-of-care test for active yaws: a comparative study.

    Science.gov (United States)

    Ayove, Telek; Houniei, Wendy; Wangnapi, Regina; Bieb, Sibauk V; Kazadi, Walter; Luke, Lisol-Nirau; Manineng, Clement; Moses, Penias; Paru, Raymond; Esfandiari, Javan; Alonso, Pedro L; de Lazzari, Elisa; Bassat, Quique; Mabey, David; Mitjà, Oriol

    2014-07-01

    To eradicate yaws, national control programmes use the Morges strategy (initial mass treatment and biannual resurveys). The resurvey component is designed to actively detect and treat remaining yaws cases and is initiated on the basis of laboratory-supported reactive non-treponemal serology (using the rapid plasma reagin [RPR] test). Unfortunately, the RPR test is available rarely in yaws-endemic areas. We sought to assess a new point-of-care assay-the Dual Path Platform (DPP) syphilis assay, which is based on simultaneous detection of antibodies to treponemal and non-treponemal antigens-for guiding use of antibiotics for yaws eradication. A secondary goal was to ascertain at what timepoint the DPP assay line reverted to negative after treatment. 703 children (aged 1-18 years) with suspected clinical yaws living in two remote, yaws-endemic villages in Papua New Guinea were enrolled. Clinical suspicion of yaws was established according to a WHO pictorial guide. We obtained blood samples from all patients. We calculated the sensitivity and specificity of the DPP assay for detection of antibodies to treponemal (T1) and non-treponemal (T2) antigens and compared values against those obtained with standard laboratory tests (the Treponema pallidum haemagglutination assay [TPHA] and the RPR test). We followed up a subsample of children with dually positive serology (T1 and T2) to monitor changes in DPP optical density (using an automatic reader) at 3 and 6 months. This trial is registered with ClinicalTrials.gov, number NCT01841203. Of 703 participants, 389 (55%) were reactive for TPHA, 305 (43%) for the RPR test, and 287 (41%) for both TPHA and the RPR test. The DPP T1 (treponemal) assay had a sensitivity of 88·4% (95% CI 84·8-91·4) and specificity of 95·2% (92·2-97·3). The DPP T2 (non-treponemal) assay had a sensitivity of 87·9% (83·7-91·3) and specificity of 92·5% (89·4-94·9). In subgroup analyses, sensitivities and specificities did not differ according to

  2. Sensitivity of Coastal Environments and Wildlife to Spilled Oil: Florida Panhandle: NESTS (Nest Points)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains sensitive biological resource data for wading birds, shorebirds, raptors, diving birds, and gulls and terns in for the Florida Panhandle....

  3. ESI-HI09 Naliikakani Point, Island of Hawaii, Hawaii 2001 (Environmental Sensitivity Index Map)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Environmental Sensitivity Index (ESI) maps are an integral component in oil-spill contingency planning and assessment. They serve as a source of information in the...

  4. Sensitivity of Coastal Environments and Wildlife to Spilled Oil: South Florida: NESTS (Nest Points)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains sensitive biological resource data for diving birds, gulls, terns, passerine birds, pelagic birds, raptors, shorebirds, wading birds, and...

  5. Sensitivity of Coastal Environments and Wildlife to Spilled Oil: Upper Coast of Texas: NESTS (Nest Points)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains sensitive biological resource data for shorebirds, diving birds, raptors, waterfowl, wading birds, terns, and gulls for the Upper Coast of...

  6. Sensitivity of Coastal Environments and Wildlife to Spilled Oil: Southern California: NESTS (Nest Points)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains sensitive biological resource data for nesting and roosting gulls, terns, seabirds, shorebirds, and T/E species in Southern California. Vector...

  7. Uncertainty and Sensitivity Analyses of a Pebble Bed HTGR Loss of Cooling Event

    Directory of Open Access Journals (Sweden)

    Gerhard Strydom

    2013-01-01

    Full Text Available The Very High Temperature Reactor Methods Development group at the Idaho National Laboratory identified the need for a defensible and systematic uncertainty and sensitivity approach in 2009. This paper summarizes the results of an uncertainty and sensitivity quantification investigation performed with the SUSA code, utilizing the International Atomic Energy Agency CRP 5 Pebble Bed Modular Reactor benchmark and the INL code suite PEBBED-THERMIX. Eight model input parameters were selected for inclusion in this study, and after the input parameters variations and probability density functions were specified, a total of 800 steady state and depressurized loss of forced cooling (DLOFC transient PEBBED-THERMIX calculations were performed. The six data sets were statistically analyzed to determine the 5% and 95% DLOFC peak fuel temperature tolerance intervals with 95% confidence levels. It was found that the uncertainties in the decay heat and graphite thermal conductivities were the most significant contributors to the propagated DLOFC peak fuel temperature uncertainty. No significant differences were observed between the results of Simple Random Sampling (SRS or Latin Hypercube Sampling (LHS data sets, and use of uniform or normal input parameter distributions also did not lead to any significant differences between these data sets.

  8. UAV-based detection and spatial analyses of periglacial landforms on Demay Point (King George Island, South Shetland Islands, Antarctica)

    Science.gov (United States)

    Dąbski, Maciej; Zmarz, Anna; Pabjanek, Piotr; Korczak-Abshire, Małgorzata; Karsznia, Izabela; Chwedorzewska, Katarzyna J.

    2017-08-01

    High-resolution aerial images allow detailed analyses of periglacial landforms, which is of particular importance in light of climate change and resulting changes in active layer thickness. The aim of this study is to show possibilities of using UAV-based photography to perform spatial analysis of periglacial landforms on the Demay Point peninsula, King George Island, and hence to supplement previous geomorphological studies of the South Shetland Islands. Photogrammetric flights were performed using a PW-ZOOM fixed-winged unmanned aircraft vehicle. Digital elevation models (DEM) and maps of slope and contour lines were prepared in ESRI ArcGIS 10.3 with the Spatial Analyst extension, and three-dimensional visualizations in ESRI ArcScene 10.3 software. Careful interpretation of orthophoto and DEM, allowed us to vectorize polygons of landforms, such as (i) solifluction landforms (solifluction sheets, tongues, and lobes); (ii) scarps, taluses, and a protalus rampart; (iii) patterned ground (hummocks, sorted circles, stripes, nets and labyrinths, and nonsorted nets and stripes); (iv) coastal landforms (cliffs and beaches); (v) landslides and mud flows; and (vi) stone fields and bedrock outcrops. We conclude that geomorphological studies based on commonly accessible aerial and satellite images can underestimate the spatial extent of periglacial landforms and result in incomplete inventories. The PW-ZOOM UAV is well suited to gather detailed geomorphological data and can be used in spatial analysis of periglacial landforms in the Western Antarctic Peninsula region.

  9. Sensitivity of Coastal Environments and Wildlife to Spilled Oil: Central California: ALERTS (Vulnerable Resource Location Points)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains vector points representing locations in Central California that should be highlighted for protection due to the presence of certain highly...

  10. Aleutian Islands Coastal Resources Inventory and Environmental Sensitivity Maps: M_MAMPT (Marine Mammal Points)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains biological resource data for seals and sea lions in the Aleutian Islands, Alaska. Points in this data set represent locations of haulout and...

  11. Surface-sensitive conductivity measurement using a micro multi-point probe approach

    DEFF Research Database (Denmark)

    Perkins, Edward; Barreto, Lucas; Wells, Justin

    2013-01-01

    measurements with an equidistant four-point probe for a wide range of contact spacings. In this way, it is possible to distinguish between bulk-like and surface-like conduction. The paper describes the design of the instrument and the approach to data and error analysis. Application examples are given......An instrument for microscale electrical transport measurements in ultra-high vacuum is presented. The setup is constructed around collinear lithographically-created multi-point probes with a contact spacing down to 500 nm. Most commonly, twelve-point probes are used. These probes are approached...... to the surface via piezoelectric positioners. Standard four-point resistance measurements can be performed using any combination of contacts out of the twelve available. Current/voltage measurements are taken semi-automatically for a variety of the possible contact configurations, effectively emulating...

  12. Aleutian Islands Coastal Resources Inventory and Environmental Sensitivity Maps: VOLCANOS (Volcano Points)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains point locations of active volcanoes as compiled by Motyka et al., 1993. Eighty-nine volcanoes with eruptive phases in the Quaternary are...

  13. Sensitivity of Coastal Environments and Wildlife to Spilled Oil: Hudson River: STAGING (Staging Site Points)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains human-use resource data for staging sites along the Hudson River. Vector points in this data set represent locations of possible staging areas...

  14. Job Demands, Burnout, and Teamwork in Healthcare Professionals Working in a General Hospital that Was Analysed At Two Points in Time

    Directory of Open Access Journals (Sweden)

    Dragan Mijakoski

    2018-04-01

    CONCLUSION: Actual longitudinal study revealed significantly higher mean values of emotional exhaustion and depersonalization in 2014 that could be explained by significantly increased job demands between analysed points in time.

  15. Reduced plantar sole sensitivity facilitates early adaptation to a visual rotation pointing task when standing upright

    Directory of Open Access Journals (Sweden)

    Maxime Billot

    2016-09-01

    Full Text Available Humans are capable of pointing to a target with accuracy. However, when vision is distorted through a visual rotation or mirror-reversed vision, the performance is initially degraded and thereafter improves with practice. There are suggestions this gradual improvement results from a sensorimotor recalibration involving initial gating of the somatosensory information from the pointing hand. In the present experiment, we examined if this process interfered with balance control by asking participants to point to targets with a visual rotation from a standing posture. This duality in processing sensory information (i.e., gating sensory signals from the hand while processing those arising from the control of balance could generate initial interference leading to a degraded pointing performance. We hypothesized that if this is the case, the attenuation of plantar sole somatosensory information through cooling could reduce the sensorimotor interference, and facilitate the early adaptation (i.e. improvement in the pointing task. Results supported this hypothesis. These observations suggest that processing sensory information for balance control interferes with the sensorimotor recalibration process imposed by a pointing task when vision is rotated.

  16. Using ambulatory care sensitive hospitalisations to analyse the effectiveness of primary care services in Mexico.

    Science.gov (United States)

    Lugo-Palacios, David G; Cairns, John

    2015-11-01

    Ambulatory care sensitive hospitalisations (ACSH) have been widely used to study the quality and effectiveness of primary care. Using data from 248 general hospitals in Mexico during 2001-2011 we identify 926,769 ACSHs in 188 health jurisdictions before and during the health insurance expansion that took place in this period, and estimate a fixed effects model to explain the association of the jurisdiction ACSH rate with patient and community factors. National ACSH rate increased by 50%, but trends and magnitude varied at the jurisdiction and state level. We find strong associations of the ACSH rate with socioeconomic conditions, health care supply and health insurance coverage even after controlling for potential endogeneity in the rolling out of the insurance programme. We argue that the traditional focus on the increase/decrease of the ACSH rate might not be a valid indicator to assess the effectiveness of primary care in a health insurance expansion setting, but that the ACSH rate is useful when compared between and within states once the variation in insurance coverage is taken into account as it allows the identification of differences in the provision of primary care. The high heterogeneity found in the ACSH rates suggests important state and jurisdiction differences in the quality and effectiveness of primary care in Mexico. Copyright © 2015 Elsevier Ltd. All rights reserved.

  17. Sensitivity analyses of acoustic impedance inversion with full-waveform inversion

    Science.gov (United States)

    Yao, Gang; da Silva, Nuno V.; Wu, Di

    2018-04-01

    Acoustic impedance estimation has a significant importance to seismic exploration. In this paper, we use full-waveform inversion to recover the impedance from seismic data, and analyze the sensitivity of the acoustic impedance with respect to the source-receiver offset of seismic data and to the initial velocity model. We parameterize the acoustic wave equation with velocity and impedance, and demonstrate three key aspects of acoustic impedance inversion. First, short-offset data are most suitable for acoustic impedance inversion. Second, acoustic impedance inversion is more compatible with the data generated by density contrasts than velocity contrasts. Finally, acoustic impedance inversion requires the starting velocity model to be very accurate for achieving a high-quality inversion. Based upon these observations, we propose a workflow for acoustic impedance inversion as: (1) building a background velocity model with travel-time tomography or reflection waveform inversion; (2) recovering the intermediate wavelength components of the velocity model with full-waveform inversion constrained by Gardner’s relation; (3) inverting the high-resolution acoustic impedance model with short-offset data through full-waveform inversion. We verify this workflow by the synthetic tests based on the Marmousi model.

  18. Uncertainty propagation on fuel cycle codes: Monte Carlo vs Sensitivity Analyses

    Energy Technology Data Exchange (ETDEWEB)

    García Martínez, M.; Alvarez-Velarde, F.

    2015-07-01

    Uncertainty propagation on fuel cycle calculations is usually limited by parametric restrictions that only allow the study of small sets of linearly correlated input and output parameters. A Monte Carlo tool has been developed in order to be able to address the simultaneous impact of several magnitudes’ uncertainties in the final results, no matter the relationship between them. TR{sub E}VOL code has been updated and optimized in order to be able to run a significant number of perturbed samples of the same reference scenario. Both a Sensitivity Analysis and a Monte Carlo technique have been implemented in the code. The first aims to address the contribution of each input parameter on the output magnitudes, while the second one is intended to provide a better estimation of the global uncertainty when non-linear relations do not allow such approach. These two methodologies have been applied to the study of a series of scenarios developed from a OECD/NEA study, which is of particular interest for Europe. The results are presented in terms of materials’ mass according to their total accumulated value, final value or maximum reached value, as defined by the user. These results are given as mean values and their uncertainties as the standard deviation of the samples. Non-linear effects can be seen as biases that affect the shape of the results’ Gaussian curves. (Author)

  19. Rapid, high sensitivity, point-of-care test for cardiac troponin based on optomagnetic biosensor

    NARCIS (Netherlands)

    Dittmer, W.U.; Evers, T.H.; Hardeman, W.M.; Huijnen-Keur, W.M.; Kamps, R.; De Kievit, P.; Neijzen, J.H.M.; Sijbers, M.J.J.; Nieuwenhuis, J.H.; Hefti, M.H.; Dekkers, D.; Martens, M.

    2010-01-01

    BACKGROUND: We present a handheld integrated device based on a novel magnetic-optical technology for the sensitive detection of cardiactroponin I, a biomarker for the positive diagnosis of myocardial infarct, in a finger-prick blood sample. The test can be performed with a turn-around time of 5

  20. Analyse of relationships between freezing point and selected indicators of udder health state among cow, goat and sheep milk

    Directory of Open Access Journals (Sweden)

    Oto Hanuš

    2009-01-01

    Full Text Available Milk freezing point (MFP is important quality indicator. Aim was to analyse the relationships of MFP to selected udder health milk indicators (MIs by comparison between cows (reference, goats and sheep. Bulk milk samples came from 3 herds of Czech Fleckvieh (B, n 93 and 1 goat herd and sheep flock (White short-haired, W, n 60; Tsigai, C, n 60. Animal nutrition was performed under the typical country conditions. MIs which were investigated: DM, dry matter; SNF, solid non fat; L, lactose (all in %; SCC, somatic cell count (103 ml−1; EC, electrical conductivity (mS cm−1; MFP (°C; Na and K (in mg kg−1. W MFP was −0.5544 ± 0.0293, B −0.5221 ± 0.0043 and C −0.6048 ± 0.0691 °C. The B MFP was related to L (−0.36; P < 0.01, W was not related to L (−0.07; P > 0.05 and C was related to L (0.40; P < 0.01. These facts could be explainable by worse SCC geometric averages for used W (3,646 103 ml−1 and C (560 103 ml−1 milk as compared to B (159 103 ml−1. Only 0.5 and 10.5% of variations in MFP were explainable by variations in DM and SNF in B, 32.7 and 12.8% in W but already 49.4 and 45.0% in C. Higher C values were caused by high MFP variability, 11.8% (C versus 0.8% (B. There is possible to derive the more reliable MFP qualitative limits for more efficient monitoring rules of milk quality problems in B, W and C.

  1. IASI's sensitivity to near-surface carbon monoxide (CO): Theoretical analyses and retrievals on test cases

    Science.gov (United States)

    Bauduin, Sophie; Clarisse, Lieven; Theunissen, Michael; George, Maya; Hurtmans, Daniel; Clerbaux, Cathy; Coheur, Pierre-François

    2017-03-01

    Separating concentrations of carbon monoxide (CO) in the boundary layer from the rest of the atmosphere with nadir satellite measurements is of particular importance to differentiate emission from transport. Although thermal infrared (TIR) satellite sounders are considered to have limited sensitivity to the composition of the near-surface atmosphere, previous studies show that they can provide information on CO close to the ground in case of high thermal contrast. In this work we investigate the capability of IASI (Infrared Atmospheric Sounding Interferometer) to retrieve near-surface CO concentrations, and we quantitatively assess the influence of thermal contrast on such retrievals. We present a 3-part analysis, which relies on both theoretical forward simulations and retrievals on real data, performed for a large range of negative and positive thermal contrast situations. First, we derive theoretically the IASI detection threshold of CO enhancement in the boundary layer, and we assess its dependence on thermal contrast. Then, using the optimal estimation formalism, we quantify the role of thermal contrast on the error budget and information content of near-surface CO retrievals. We demonstrate that, contrary to what is usually accepted, large negative thermal contrast values (ground cooler than air) lead to a better decorrelation between CO concentrations in the low and the high troposphere than large positive thermal contrast (ground warmer than the air). In the last part of the paper we use Mexico City and Barrow as test cases to contrast our theoretical predictions with real retrievals, and to assess the accuracy of IASI surface CO retrievals through comparisons to ground-based in-situ measurements.

  2. Chronic whiplash and central sensitization; an evaluation of the role of a myofascial trigger points in pain modulation

    Directory of Open Access Journals (Sweden)

    Freeman Michael D

    2009-04-01

    Full Text Available Abstract Objective it has been established that chronic neck pain following whiplash is associated with the phenomenon of central sensitization, in which injured and uninjured parts of the body exhibit lowered pain thresholds due to an alteration in central pain processing. it has furthermore been hypothesized that peripheral sources of nociception in the muscles may perpetuate central sensitization in chronic whiplash. the hypothesis explored in the present study was whether myofascial trigger points serve as a modulator of central sensitization in subjects with chronic neck pain. Design controlled case series. Setting outpatient chronic pain clinic. Subjects seventeen patients with chronic and intractable neck pain and 10 healthy controls without complaints of neck pain. Intervention symptomatic subjects received anesthetic infiltration of myofascial trigger points in the upper trapezius muscles and controls received the anesthetic in the thigh. Outcome measures: pre and post injection cervical range of motion, pressure pain thresholds (ppt over the infraspinatus, wrist extensor, and tibialis anterior muscles. sensitivity to light (photophobia and subjects' perception of pain using a visual analog scale (vas were also evaluated before and after injections. only the ppt was evaluated in the asymptomatic controls. Results immediate (within 1 minute alterations in cervical range of motion and pressure pain thresholds were observed following an average of 3.8 injections with 1–2 cc of 1% lidocaine into carefully identified trigger points. cervical range of motion increased by an average of 49% (p = 0.000 in flexion and 44% (p = 0.001 in extension, 47% (p = 0.000 and 28% (p Conclusion the present data suggest that myofascial trigger points serve to perpetuate lowered pain thresholds in uninjured tissues. additionally, it appears that lowered pain thresholds associated with central sensitization can be immediately reversed, even when associated

  3. Performance Assessment and Sensitivity Analyses of Disposal of Plutonium as Can-in-Canister Ceramic

    International Nuclear Information System (INIS)

    Rainer Senger

    2001-01-01

    The purpose of this analysis is to examine whether there is a justification for using high-level waste (HLW) as a surrogate for plutonium disposal in can-in-canister ceramic in the total-system performance assessment (TSPA) model for the Site Recommendation (SR). In the TSPA-SR model, the immobilized plutonium waste form is not explicitly represented, but is implicitly represented as an equal number of canisters of HLW. There are about 50 metric tons of plutonium in the U. S. Department of Energy inventory of surplus fissile material that could be disposed. Approximately 17 tons of this material contain significant quantities of impurities and are considered unsuitable for mixed-oxide (MOX) reactor fuel. This material has been designated for direct disposal by immobilization in a ceramic waste form and encapsulating this waste form in high-level waste (HLW). The remaining plutonium is suitable for incorporation into MOX fuel assemblies for commercial reactors (Shaw 1999, Section 2). In this analysis, two cases of immobilized plutonium disposal are analyzed, the 17-ton case and the 13-ton case (Shaw et al. 2001, Section 2.2). The MOX spent-fuel disposal is not analyzed in this report. In the TSPA-VA (CRWMS M and O 1998a, Appendix B, Section B-4), the calculated dose release from immobilized plutonium waste form (can-in-canister ceramic) did not exceed that from an equivalent amount of HLW glass. This indicates that the HLW could be used as a surrogate for the plutonium can-in-canister ceramic. Representation of can-in-canister ceramic as a surrogate is necessary to reduce the number of waste forms in the TSPA model. This reduction reduces the complexity and running time of the TSPA model and makes the analyses tractable. This document was developed under a Technical Work Plan (CRWMS M and O 2000a), and is compliant with that plan. The application of the Quality Assurance (QA) program to the development of that plan (CRWMS M and O 2000a) and of this Analysis is

  4. A regional tidal/subtidal circulation model of the southeastern Bering Sea: development, sensitivity analyses and hindcasting

    Science.gov (United States)

    Hermann, Albert J.; Stabeno, Phyllis J.; Haidvogel, Dale B.; Musgrave, David L.

    2002-12-01

    A regional eddy-resolving primitive equation circulation model was used to simulate circulation on the southeastern Bering Sea (SEBS) shelf and basin. This model resolves the dominant observed mean currents, eddies and meanders in the region, and simultaneously includes both tidal and subtidal dynamics. Circulation, temperature, and salinity fields for years 1995 and 1997 were hindcast, using daily wind and buoyancy flux estimates, and tidal forcing derived from a global model. This paper describes the development of the regional model, a comparison of model results with available Eulerian and Lagrangian data, a comparison of results between the two hindcast years, and a sensitivity analysis. Based on these hindcasts and sensitivity analyses, we suggest the following: (1) The Bering Slope Current is a primary source of large ( ˜100 km diameter) eddies in the SEBS basin. Smaller meanders are also formed along the 100 m isobath on the southeastern shelf, and along the 200-m isobath near the shelf break. (2) There is substantial interannual variability in the statistics of eddies within the basin, driven by variability in the strength of the ANSC. (3) The mean flow on the shelf is not strongly sensitive to changes in the imposed strength of the ANSC; rather, it is strongly sensitive to the local wind forcing. (4) Vertical mixing in the SEBS is strongly affected by both tidal and subtidal dynamics. Strongest mixing in the SEBS may in fact occur between the 100- and 400-m isobaths, near the Pribilof Islands, and in Unimak Pass.

  5. Thermal Error Modeling Method with the Jamming of Temperature-Sensitive Points' Volatility on CNC Machine Tools

    Science.gov (United States)

    MIAO, Enming; LIU, Yi; XU, Jianguo; LIU, Hui

    2017-05-01

    Aiming at the deficiency of the robustness of thermal error compensation models of CNC machine tools, the mechanism of improving the models' robustness is studied by regarding the Leaderway-V450 machining center as the object. Through the analysis of actual spindle air cutting experimental data on Leaderway-V450 machine, it is found that the temperature-sensitive points used for modeling is volatility, and this volatility directly leads to large changes on the collinear degree among modeling independent variables. Thus, the forecasting accuracy of multivariate regression model is severely affected, and the forecasting robustness becomes poor too. To overcome this effect, a modeling method of establishing thermal error models by using single temperature variable under the jamming of temperature-sensitive points' volatility is put forward. According to the actual data of thermal error measured in different seasons, it is proved that the single temperature variable model can reduce the loss of forecasting accuracy resulted from the volatility of temperature-sensitive points, especially for the prediction of cross quarter data, the improvement of forecasting accuracy is about 5 μm or more. The purpose that improving the robustness of the thermal error models is realized, which can provide a reference for selecting the modeling independent variable in the application of thermal error compensation of CNC machine tools.

  6. Spontaneous fluctuation indices of the cardiovagal baroreflex accurately measure the baroreflex sensitivity at the operating point during upright tilt.

    Science.gov (United States)

    Schwartz, Christopher E; Medow, Marvin S; Messer, Zachary; Stewart, Julian M

    2013-06-15

    Spontaneous fluctuation indices of cardiovagal baroreflex have been suggested to be inaccurate measures of baroreflex function during orthostatic stress compared with alternate open-loop methods (e.g. neck pressure/suction, modified Oxford method). We therefore tested the hypothesis that spontaneous fluctuation measurements accurately reflect local baroreflex gain (slope) at the operating point measured by the modified Oxford method, and that apparent differences between these two techniques during orthostasis can be explained by a resetting of the baroreflex function curve. We computed the sigmoidal baroreflex function curves supine and during 70° tilt in 12 young, healthy individuals. With the use of the modified Oxford method, slopes (gains) of supine and upright curves were computed at their maxima (Gmax) and operating points. These were compared with measurements of spontaneous indices in both positions. Supine spontaneous analyses of operating point slope were similar to calculated Gmax of the modified Oxford curve. In contrast, upright operating point was distant from the centering point of the reset curve and fell on the nonlinear portion of the curve. Whereas spontaneous fluctuation measurements were commensurate with the calculated slope of the upright modified Oxford curve at the operating point, they were significantly lower than Gmax. In conclusion, spontaneous measurements of cardiovagal baroreflex function accurately estimate the slope near operating points in both supine and upright position.

  7. Reproduction of the Yucca Mountain Project TSPA-LA Uncertainty and Sensitivity Analyses and Preliminary Upgrade of Models

    Energy Technology Data Exchange (ETDEWEB)

    Hadgu, Teklu [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Nuclear Waste Disposal Research and Analysis; Appel, Gordon John [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Nuclear Waste Disposal Research and Analysis

    2016-09-01

    Sandia National Laboratories (SNL) continued evaluation of total system performance assessment (TSPA) computing systems for the previously considered Yucca Mountain Project (YMP). This was done to maintain the operational readiness of the computing infrastructure (computer hardware and software) and knowledge capability for total system performance assessment (TSPA) type analysis, as directed by the National Nuclear Security Administration (NNSA), DOE 2010. This work is a continuation of the ongoing readiness evaluation reported in Lee and Hadgu (2014) and Hadgu et al. (2015). The TSPA computing hardware (CL2014) and storage system described in Hadgu et al. (2015) were used for the current analysis. One floating license of GoldSim with Versions 9.60.300, 10.5 and 11.1.6 was installed on the cluster head node, and its distributed processing capability was mapped on the cluster processors. Other supporting software were tested and installed to support the TSPA-type analysis on the server cluster. The current tasks included verification of the TSPA-LA uncertainty and sensitivity analyses, and preliminary upgrade of the TSPA-LA from Version 9.60.300 to the latest version 11.1. All the TSPA-LA uncertainty and sensitivity analyses modeling cases were successfully tested and verified for the model reproducibility on the upgraded 2014 server cluster (CL2014). The uncertainty and sensitivity analyses used TSPA-LA modeling cases output generated in FY15 based on GoldSim Version 9.60.300 documented in Hadgu et al. (2015). The model upgrade task successfully converted the Nominal Modeling case to GoldSim Version 11.1. Upgrade of the remaining of the modeling cases and distributed processing tasks will continue. The 2014 server cluster and supporting software systems are fully operational to support TSPA-LA type analysis.

  8. Neuro Emotional Technique for the treatment of trigger point sensitivity in chronic neck pain sufferers: A controlled clinical trial

    Directory of Open Access Journals (Sweden)

    Pollard Henry

    2008-05-01

    Full Text Available Abstract Background Trigger points have been shown to be active in many myofascial pain syndromes. Treatment of trigger point pain and dysfunction may be explained through the mechanisms of central and peripheral paradigms. This study aimed to investigate whether the mind/body treatment of Neuro Emotional Technique (NET could significantly relieve pain sensitivity of trigger points presenting in a cohort of chronic neck pain sufferers. Methods Sixty participants presenting to a private chiropractic clinic with chronic cervical pain as their primary complaint were sequentially allocated into treatment and control groups. Participants in the treatment group received a short course of Neuro Emotional Technique that consists of muscle testing, general semantics and Traditional Chinese Medicine. The control group received a sham NET protocol. Outcome measurements included pain assessment utilizing a visual analog scale and a pressure gauge algometer. Pain sensitivity was measured at four trigger point locations: suboccipital region (S; levator scapulae region (LS; sternocleidomastoid region (SCM and temporomandibular region (TMJ. For each outcome measurement and each trigger point, we calculated the change in measurement between pre- and post- treatment. We then examined the relationships between these measurement changes and six independent variables (i.e. treatment group and the above five additional participant variables using forward stepwise General Linear Model. Results The visual analog scale (0 to 10 had an improvement of 7.6 at S, 7.2 at LS, 7.5 at SCM and 7.1 at the TMJ in the treatment group compared with no improvement of at S, and an improvement of 0.04 at LS, 0.1 at SCM and 0.1 at the TMJ point in the control group, (P Conclusion After a short course of NET treatment, measurements of visual analog scale and pressure algometer recordings of four trigger point locations in a cohort of chronic neck pain sufferers were significantly

  9. Neuro Emotional Technique for the treatment of trigger point sensitivity in chronic neck pain sufferers: a controlled clinical trial.

    Science.gov (United States)

    Bablis, Peter; Pollard, Henry; Bonello, Rod

    2008-05-21

    Trigger points have been shown to be active in many myofascial pain syndromes. Treatment of trigger point pain and dysfunction may be explained through the mechanisms of central and peripheral paradigms. This study aimed to investigate whether the mind/body treatment of Neuro Emotional Technique (NET) could significantly relieve pain sensitivity of trigger points presenting in a cohort of chronic neck pain sufferers. Sixty participants presenting to a private chiropractic clinic with chronic cervical pain as their primary complaint were sequentially allocated into treatment and control groups. Participants in the treatment group received a short course of Neuro Emotional Technique that consists of muscle testing, general semantics and Traditional Chinese Medicine. The control group received a sham NET protocol. Outcome measurements included pain assessment utilizing a visual analog scale and a pressure gauge algometer. Pain sensitivity was measured at four trigger point locations: suboccipital region (S); levator scapulae region (LS); sternocleidomastoid region (SCM) and temporomandibular region (TMJ). For each outcome measurement and each trigger point, we calculated the change in measurement between pre- and post- treatment. We then examined the relationships between these measurement changes and six independent variables (i.e. treatment group and the above five additional participant variables) using forward stepwise General Linear Model. The visual analog scale (0 to 10) had an improvement of 7.6 at S, 7.2 at LS, 7.5 at SCM and 7.1 at the TMJ in the treatment group compared with no improvement of at S, and an improvement of 0.04 at LS, 0.1 at SCM and 0.1 at the TMJ point in the control group, (P algometer recordings of four trigger point locations in a cohort of chronic neck pain sufferers were significantly improved when compared to a control group which received a sham protocol of NET. Chronic neck pain sufferers may benefit from NET treatment in the relief

  10. Dual-cloud point extraction and tertiary amine labeling for selective and sensitive capillary electrophoresis-electrochemiluminescent detection of auxins.

    Science.gov (United States)

    Yin, Xue-Bo; Guo, Jun-Min; Wei, Wei

    2010-02-19

    The low concentrations of the auxins in samples of plant tissue necessitate the use of selective and sensitive techniques for their quantification. Herein a selective and sensitive method based on dual-cloud point extraction (dCPE) and tertiary amine labeling for the quantification of indole-3-acetic acid (IAA) and indole-3-butyric acid (IBA) by capillary electrophoresis-electrochemiluminescence (CE-ECL) is proposed. The procedure for dCPE included two cloud point processes with Triton X-114 as the extractant. The two auxins became hydrophobic in an acidic solution and were extracted into surfactant-rich phase after the first cloud point procedure. They were then back-extracted into the alkaline aqueous phase during the second cloud point step. The extracted auxins were reacted with 2-(2-aminoethyl)-1-methylpyrrolidine (AEMP) in acetonitrile that contained N,N'-dicyclohexylcarbodiimide and 3,4-dihydro-3-hydroxy-4-oxo-1,2,3-benzotriazine to produce their AEMP-derivatives. The two auxin-AEMP-derivatives were subjected into CE and detected by Ru(bpy)(3)(2+)-based ECL. The preconcentration factors for IAA and IBA with dCPE were 40.5 and 43.4, respectively. The on-capillary detection limits (S/N=3) were 2.5 and 2.8nM for IAA and IBA. This protocol presents a clear advantage in that it reduces the interference from the matrixes extensively and gives a high sensitivity for the detection of auxins. The proposed method was applied successfully to the detection of the two auxins in acacia tender leaves, buds, and bean sprout. Copyright 2009 Elsevier B.V. All rights reserved.

  11. Sensitivity and uncertainty analyses of unsaturated flow travel time in the CHnz unit of Yucca Mountain, Nevada

    International Nuclear Information System (INIS)

    Nichols, W.E.; Freshley, M.D.

    1991-10-01

    This report documents the results of sensitivity and uncertainty analyses conducted to improve understanding of unsaturated zone ground-water travel time distribution at Yucca Mountain, Nevada. The US Department of Energy (DOE) is currently performing detailed studies at Yucca Mountain to determine its suitability as a host for a geologic repository for the containment of high-level nuclear wastes. As part of these studies, DOE is conducting a series of Performance Assessment Calculational Exercises, referred to as the PACE problems. The work documented in this report represents a part of the PACE-90 problems that addresses the effects of natural barriers of the site that will stop or impede the long-term movement of radionuclides from the potential repository to the accessible environment. In particular, analyses described in this report were designed to investigate the sensitivity of the ground-water travel time distribution to different input parameters and the impact of uncertainty associated with those input parameters. Five input parameters were investigated in this study: recharge rate, saturated hydraulic conductivity, matrix porosity, and two curve-fitting parameters used for the van Genuchten relations to quantify the unsaturated moisture-retention and hydraulic characteristics of the matrix. 23 refs., 20 figs., 10 tabs

  12. Surface Observation and Pore Size Analyses of Polypropylene/Low-Melting Point Polyester Filter Materials: Influences of Heat Treatment

    Directory of Open Access Journals (Sweden)

    Lin Jia-Horng

    2016-01-01

    Full Text Available This study proposes making filter materials with polypropylene (PP and low-melting point (LPET fibers. The influences of temperatures and times of heat treatment on the morphology of thermal bonding points and average pore size of the PP/LPET filter materials. The test results indicate that the morphology of thermal bonding points is highly correlated with the average pore size. When the temperature of heat treatment is increased, the fibers are joined first with the thermal bonding points, and then with the large thermal bonding areas, thereby decreasing the average pore size of the PP/LPET filter materials. A heat treatment of 110 °C for 60 seconds can decrease the pore size from 39.6 μm to 12.0 μm.

  13. From water analytics to the point-of-care-testing. Biosensors for the quantitative analysis in different matrices; Von der Wasseranalytik bis zum Point-of-Care-Testing. Biosensoren zur quantitativen Analyse in verschiedenen Matrices

    Energy Technology Data Exchange (ETDEWEB)

    Albrecht, C.; Gauglitz, G. [Tuebingen Univ. (DE). Inst. fuer Physikalische und Theoretische Chemie (IPTC)

    2008-03-15

    In many ranges of control analytics, a continuous monitoring is increasingly necessary. Classical methods such as gas chromatography or HPLC enable a sensitive proof of analytes. However, these classical methods are not suitable for high flow rates. Biosensors fulfill the requirements of a fast, economical and sensitive detection. Under this aspect, the authors of the contribution under consideration report on biosensors for the automated employment with the quantitative measurement in different matrices. The modular structure of the used surface chemistry permits a flexible adjustment to extern conditions. Thus a high stability of the sensitive, biological layer is to be achieved. The potential of the technology is pointed out on the basis of three applications to the measurement in water, cow's milk and human serum (point-of-care-testing).

  14. Walsh-Hadamard-Based 3-D Steganography for Protecting Sensitive Information in Point-of-Care.

    Science.gov (United States)

    Abuadbba, Alsharif; Khalil, Ibrahim

    2017-09-01

    Remote points-of-care has recently had a lot of attention for their advantages such as saving lives and cost reduction. The transmitted streams usually contain 1) normal biomedical signals (e.g., electrocardiograms) and 2) highly private information (e.g., patient identity). Despite the obvious advantages, the primary concerns are privacy and authenticity of the transferred data. Therefore, this paper introduces a novel steganographic mechanism that ensures 1) strong privacy preservation of private information by random concealing inside the transferred signals employing a key and 2) evidence of originality for the biomedical signals. To maximize hiding, fast Walsh-Hadamard transform is utilized to transform the signals into a group of coefficients. To ensure the lowest distortion, only less-significant values of coefficients are employed. To strengthen security, the key is utilized in a three-dimensional (3-D) random coefficients' reform to produce a 3-D order employed in the concealing process. The resultant distortion has been thoroughly measured in all stages. After extensive experiments on three types of signals, it has been proved that the algorithm has a little impact on the genuine signals ( 1 %). The security evaluation also confirms that unlawful retrieval of the hidden information within rational time is mightily improbable.

  15. Evaluating the effect of sample type on American alligator (Alligator mississippiensis) analyte values in a point-of-care blood analyser

    OpenAIRE

    Hamilton, Matthew T.; Finger, John W.; Winzeler, Megan E.; Tuberville, Tracey D.

    2016-01-01

    The assessment of wildlife health has been enhanced by the ability of point-of-care (POC) blood analysers to provide biochemical analyses of non-domesticated animals in the field. However, environmental limitations (e.g. temperature, atmospheric humidity and rain) and lack of reference values may inhibit researchers from using such a device with certain wildlife species. Evaluating the use of alternative sample types, such as plasma, in a POC device may afford researchers the opportunity to d...

  16. Why the Center-Point of Bridged Carbon Nanotube Length is the Most Mass Sensitive Location for Mass Attachment?

    DEFF Research Database (Denmark)

    Mehdipour, I; Barari, Amin

    2012-01-01

    The continuum mechanics method and a bending model were used to obtain the resonant frequencies of bridged single-walled carbon nanotubes (SWCNTs) with masses rigidly attached at various positions along the tube. The frequency response equations were derived using the Euler–Bernoulli theory....... The resonant frequency decreased as the mass was increased, and the mass sensitivity increased as the attachment position approached the center of the bridged tube. The validity and accuracy of the equations were compared to other mass sensor models described in the literature. These new sensor equations may...... be used to model the behavior of CNT-based biosensors with reasonable accuracy. As a result, center point of bridged carbon nanotube is the most sensitive location for mass attachment....

  17. Frequency and Proximity Clustering Analyses for Georeferencing Toponyms and Points-of-Interest Names from a Travel Journal

    Science.gov (United States)

    McDermott, Scott D.

    2017-01-01

    This research study uses geographic information retrieval (GIR) to georeference toponyms and points-of-interest (POI) names from a travel journal. Travel journals are an ideal data source with which to conduct this study because they are significant accounts specific to the author's experience, and contain geographic instances based on the…

  18. Preliminary investigation of fuel cycle in fast reactors by the correlations method and sensitivity analyses of nuclear characteristics

    International Nuclear Information System (INIS)

    Amorim, E.S. do; Castro Lobo, P.D. de.

    1980-11-01

    A reduction of computing effort was achieved as a result of the application of space - independent continuous slowing down theory in the spectrum averaged cross sections and further expressing then in a quadratic corelation whith the temperature and the composition. The decoupling between variables that express some of the important nuclear characteristics allowed to introduce a sensitivity analyses treatment for the full prediction of the behavior, over the fuel cycle, of the LMFBR considered. As a potential application of the method here in developed is to predict the nuclear characteristics of another reactor, face some reference reactor of the family considered. Excellent agreement with exact calculation is observed only when perturbations occur in nuclear data and/or fuel isotopic characteristics, but fair results are obtained whith variations in system components other than the fuel. (Author) [pt

  19. Trend and change point analyses of annual precipitation in the Souss-Massa Region in Morocco during 1932-2010

    Science.gov (United States)

    Abahous, H.; Ronchail, J.; Sifeddine, A.; Kenny, L.; Bouchaou, L.

    2017-11-01

    In the context of an arid area such as Souss Massa Region, the availability of time series analysis of observed local data is vital to better characterize the regional rainfall configuration. In this paper, dataset of monthly precipitation collected from different local meteorological stations during 1932-2010, are quality controlled and analyzed to detect trend and change points. The temporal distribution of outliers shows an annual cycle and a decrease of their number since the 1980s. The results of the standard normal homogeneity test, penalized maximal t test, and Mann-Whitney-Pettit test show that 42% of the series are homogeneous. The analysis of annual precipitation in the region of Souss Massa during 1932-2010 shows wet conditions with a maximum between 1963 and 1965 followed by a decrease since 1973. The latter is identified as a statistically significant regional change point in Western High Atlas and Anti Atlas Mountains highlighting a decline in long-term average precipitation.

  20. Uncertainty and sensitivity analyses for gas and brine migration at the Waste Isolation Pilot Plant, May 1992

    Energy Technology Data Exchange (ETDEWEB)

    Helton, J.C. [Arizona State Univ., Tempe, AZ (United States); Bean, J.E. [New Mexico Engineering Research Inst., Albuquerque, NM (United States); Butcher, B.M. [Sandia National Labs., Albuquerque, NM (United States); Garner, J.W.; Vaughn, P. [Applied Physics, Inc., Albuquerque, NM (United States); Schreiber, J.D. [Science Applications International Corp., Albuquerque, NM (United States); Swift, P.N. [Tech Reps, Inc., Albuquerque, NM (United States)

    1993-08-01

    Uncertainty and sensitivity analysis techniques based on Latin hypercube sampling, partial correlation analysis, stepwise regression analysis and examination of scatterplots are used in conjunction with the BRAGFLO model to examine two phase flow (i.e., gas and brine) at the Waste Isolation Pilot Plant (WIPP), which is being developed by the US Department of Energy as a disposal facility for transuranic waste. The analyses consider either a single waste panel or the entire repository in conjunction with the following cases: (1) fully consolidated shaft, (2) system of shaft seals with panel seals, and (3) single shaft seal without panel seals. The purpose of this analysis is to develop insights on factors that are potentially important in showing compliance with applicable regulations of the US Environmental Protection Agency (i.e., 40 CFR 191, Subpart B; 40 CFR 268). The primary topics investigated are (1) gas production due to corrosion of steel, (2) gas production due to microbial degradation of cellulosics, (3) gas migration into anhydrite marker beds in the Salado Formation, (4) gas migration through a system of shaft seals to overlying strata, and (5) gas migration through a single shaft seal to overlying strata. Important variables identified in the analyses include initial brine saturation of the waste, stoichiometric terms for corrosion of steel and microbial degradation of cellulosics, gas barrier pressure in the anhydrite marker beds, shaft seal permeability, and panel seal permeability.

  1. Lateral Flow Assay Based on Paper-Hydrogel Hybrid Material for Sensitive Point-of-Care Detection of Dengue Virus.

    Science.gov (United States)

    Choi, Jane Ru; Yong, Kar Wey; Tang, Ruihua; Gong, Yan; Wen, Ting; Yang, Hui; Li, Ang; Chia, Yook Chin; Pingguan-Murphy, Belinda; Xu, Feng

    2017-01-01

    Paper-based devices have been broadly used for the point-of-care detection of dengue viral nucleic acids due to their simplicity, cost-effectiveness, and readily observable colorimetric readout. However, their moderate sensitivity and functionality have limited their applications. Despite the above-mentioned advantages, paper substrates are lacking in their ability to control fluid flow, in contrast to the flow control enabled by polymer substrates (e.g., agarose) with readily tunable pore size and porosity. Herein, taking the benefits from both materials, the authors propose a strategy to create a hybrid substrate by incorporating agarose into the test strip to achieve flow control for optimal biomolecule interactions. As compared to the unmodified test strip, this strategy allows sensitive detection of targets with an approximately tenfold signal improvement. Additionally, the authors showcase the potential of functionality improvement by creating multiple test zones for semi-quantification of targets, suggesting that the number of visible test zones is directly proportional to the target concentration. The authors further demonstrate the potential of their proposed strategy for clinical assessment by applying it to their prototype sample-to-result test strip to sensitively and semi-quantitatively detect dengue viral RNA from the clinical blood samples. This proposed strategy holds significant promise for detecting various targets for diverse future applications. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  2. Evaluation of pain sensitivity by tender point counts and myalgic score in patients with and without obstructive sleep apnea syndrome.

    Science.gov (United States)

    Terzi, Rabia; Yılmaz, Zahide

    2017-03-01

    The purpose of this study was to assess the difference between patients with and without obstructive sleep apnea syndrome (OSAS) with respect to pain sensitivity. The study was conducted on 31 womens diagnosed with OSAS and 31 healthy women. All patients underwent polysomnographic testing. A pressure algometer (dolorimeter) was used to measure the pressure pain threshold. Fibromyalgia was diagnosed based on the 1990 American College of Rheumatology diagnosis criteria. The myalgic score was 73.95 ± 18.09 in patients with OSAS, while this value was 84.18 ± 24.31 in the control group. The difference between the groups was statistically significant (P = 0.041).The number of tender points was 8.19 ± 3.35 in the patient group with OSAS, while this number was 6.35 ± 2.23 in the control group. The difference between the two groups was statistically significant (P = 0.014). No statistically significant differences were found between age, body mass index, Beck depression scores, control point score and the presence of fibromyalgia, between the two groups (P > 0.05). A statistically significant positive correlation was found between the myalgic scores and mean saturation O 2 (%) values of the patients (r = 0.357; P = 0.049). The differences noted between OSAS patients and the control group with respect to myalgic score and the number of tender points suggest that there might be a relation between OSAS and pain sensitivity. There might be an association between low oxygen saturation and total myalgic score. © 2015 Asia Pacific League of Associations for Rheumatology and Wiley Publishing Asia Pty Ltd.

  3. Tackling reproducibility in microcantilever biosensors: a statistical approach for sensitive and specific end-point detection of immunoreactions.

    Science.gov (United States)

    Kosaka, Priscila M; Tamayo, Javier; Ruz, José J; Puertas, Sara; Polo, Ester; Grazu, Valeria; de la Fuente, Jesús M; Calleja, Montserrat

    2013-02-21

    In the last decade, microcantilever biosensors have shown enormous potential for highly sensitive label-free detection of nucleic acid and proteins. Despite the enormous advances, the promise of applications of this technology in the biomedical field has been frustrated because of its low reproducibility. Here we tackle the reproducibility issue in microcantilever biosensors and provide the guidelines to minimize the deviations in the biosensor response between different assays. We use as a model system the label-free end-point detection of horseradish peroxidase. We choose the end-point detection mode because of its suitability for implementation in the clinical field that requires simplicity and point-of-care capability. Our study comprises the analysis of 1012 cantilevers with different antibody surface densities, two blocking strategies based on polyethylene-glycol (PEG) and bovine serum albumin (BSA) and stringent controls. The study reveals that the performance of the assay critically depends on both antibody surface density and blocking strategies. We find that the optimal conditions involve antibody surface densities near but below saturation and blocking with PEG. We find that the surface stress induced by the antibody-antigen binding is significantly correlated with the surface stress generated during the antibody attachment and blocking steps. The statistical correlation is harnessed to identify immobilization failure or success, and thus enhancing the specificity and sensitivity of the assay. This procedure enables achieving rates of true positives and true negatives of 90% and 91% respectively. The detection limit is of 10 ng mL(-1) (250 pM) that is similar to the detection limit obtained in our enzyme-linked immunosorbent assay (ELISA) and at least two orders of magnitude smaller than that achieved with well-established label-free biosensors such as a quartz crystal microbalance (QCM) and surface plasmon resonance (SPR) sensor.

  4. Combined comparative genomic hybridization and transcriptomic analyses of ovarian granulosa cell tumors point to novel candidate driver genes.

    Science.gov (United States)

    Caburet, Sandrine; Anttonen, Mikko; Todeschini, Anne-Laure; Unkila-Kallio, Leila; Mestivier, Denis; Butzow, Ralf; Veitia, Reiner A

    2015-04-10

    Ovarian granulosa cell tumors (GCTs) are the most frequent sex cord-stromal tumors. Several studies have shown that a somatic mutation leading to a C134W substitution in the transcription factor FOXL2 appears in more than 95% of adult-type GCTs. Its pervasive presence suggests that FOXL2 is the main cancer driver gene. However, other mutations and genomic changes might also contribute to tumor formation and/or progression. We have performed a combined comparative genomic hybridization and transcriptomic analyses of 10 adult-type GCTs to obtain a picture of the genomic landscape of this cancer type and to identify new candidate co-driver genes. Our results, along with a review of previous molecular studies, show the existence of highly recurrent chromosomal imbalances (especially, trisomy 14 and monosomy 22) and preferential co-occurrences (i.e. trisomy 14/monosomy 22 and trisomy 7/monosomy 16q). In-depth analyses showed the presence of recurrently broken, amplified/duplicated or deleted genes. Many of these genes, such as AKT1, RUNX1 and LIMA1, are known to be involved in cancer and related processes. Further genomic explorations suggest that they are functionally related. Our combined analysis identifies potential candidate genes, whose alterations might contribute to adult-type GCT formation/progression together with the recurrent FOXL2 somatic mutation.

  5. Flight time beta spectrometer with position sensitive detectors for electronic structure investigation at points of hydrogen adsorption on surface

    International Nuclear Information System (INIS)

    Zhdanov, V.S.; Petukhov, V.K.; Burminsky, V.P.; Lubov, S.K.

    1997-01-01

    The basis of flight time beta spectrometer for investigation of electronic emission with energy not over 500 eV have been created. This device will be used for carrying out the first study of electronic structure at the points of hydrogen adsorption through the measuring of spectra of Auger relaxation electrons emitted by the system investigated surface-tritium. The momentum resolution of beta spectrometer accounts for (0,1 - 0,2)% at 'traditional' solid angle equals to 0,25% from 4π sr owing to the use positron sensitive start and stop detectors on a basis of microchannel plates. Taking into consideration that the area of our beta source is minimum 100 times larger as compared to 'traditional' spectrometers and a spectrum here is registered simultaneously over all energy interval containing useful information, we obtain high quality beta spectrometer. (author)

  6. Evaluation of portable point-of-care CD4 counter with high sensitivity for detecting patients eligible for antiretroviral therapy.

    Directory of Open Access Journals (Sweden)

    Yukari C Manabe

    Full Text Available BACKGROUND: Accurate, inexpensive point-of-care CD4+ T cell testing technologies are needed that can deliver CD4+ T cell results at lower level health centers or community outreach voluntary counseling and testing. We sought to evaluate a point-of-care CD4+ T cell counter, the Pima CD4 Test System, a portable, battery-operated bench-top instrument that is designed to use finger stick blood samples suitable for field use in conjunction with rapid HIV testing. METHODS: Duplicate measurements were performed on both capillary and venous samples using Pima CD4 analyzers, compared to the BD FACSCalibur (reference method. The mean bias was estimated by paired Student's t-test. Bland Altman plots were used to assess agreement. RESULTS: 206 participants were enrolled with a median CD4 count of 396 (range; 18-1500. The finger stick PIMA had a mean bias of -66.3 cells/µL (95%CI -83.4-49.2, P500 cells/µL with a mean bias of -120.6 (95%CI -162.8, -78.4, P<0.001. The sensitivity (95%CI of the Pima CD4 analyzer was 96.3% (79.1-99.8% for a <250 cells/ul cut-off with a negative predictive value of 99.2% (95.1-99.9%. CONCLUSIONS: The Pima CD4 finger stick test is an easy-to-use, portable, relatively fast device to test CD4+ T cell counts in the field. Issues of negatively-biased CD4 cell counts especially at higher absolute numbers will limit its utility for longitudinal immunologic response to ART. The high sensitivity and negative predictive value of the test makes it an attractive option for field use to identify patients eligible for ART, thus potentially reducing delays in linkage to care and ART initiation.

  7. Analysing the Zenith Tropospheric Delay Estimates in On-line Precise Point Positioning (PPP) Services and PPP Software Packages.

    Science.gov (United States)

    Mendez Astudillo, Jorge; Lau, Lawrence; Tang, Yu-Ting; Moore, Terry

    2018-02-14

    As Global Navigation Satellite System (GNSS) signals travel through the troposphere, a tropospheric delay occurs due to a change in the refractive index of the medium. The Precise Point Positioning (PPP) technique can achieve centimeter/millimeter positioning accuracy with only one GNSS receiver. The Zenith Tropospheric Delay (ZTD) is estimated alongside with the position unknowns in PPP. Estimated ZTD can be very useful for meteorological applications, an example is the estimation of water vapor content in the atmosphere from the estimated ZTD. PPP is implemented with different algorithms and models in online services and software packages. In this study, a performance assessment with analysis of ZTD estimates from three PPP online services and three software packages is presented. The main contribution of this paper is to show the accuracy of ZTD estimation achievable in PPP. The analysis also provides the GNSS users and researchers the insight of the processing algorithm dependence and impact on PPP ZTD estimation. Observation data of eight whole days from a total of nine International GNSS Service (IGS) tracking stations spread in the northern hemisphere, the equatorial region and the southern hemisphere is used in this analysis. The PPP ZTD estimates are compared with the ZTD obtained from the IGS tropospheric product of the same days. The estimates of two of the three online PPP services show good agreement (PPP services perform better than the selected PPP software packages at all stations.

  8. Sensitivity and Specificity Improvement in Abdominal Obesity Diagnosis Using Cluster Analysis during Waist Circumference Cut-Off Point Selection

    Directory of Open Access Journals (Sweden)

    Valmore Bermúdez

    2015-01-01

    Full Text Available Introduction. The purpose of this study was to analyze the influence of metabolic phenotypes during the construction of ROC curves for waist circumference (WC cutpoint selection. Materials and Methods. A total of 1,902 subjects of both genders were selected from the Maracaibo City Metabolic Syndrome Prevalence Study database. Two-Step Cluster Analysis (TSCA was applied to select metabolically healthy and sick men and women. ROC curves were constructed to determine WC cutoff points by gender. Results. Through TSCA, metabolic phenotype predictive variables were selected: HOMA2-IR and HOMA2-βcell for women and HOMA2-IR, HOMA2-βcell, and TAG for men. Subjects were classified as healthy normal weight, metabolically obese normal weight, healthy and metabolically disturbed overweight, and healthy and metabolically disturbed obese. Final WC cutpoints were 91.50 cm for women (93.4% sensitivity, 93.7% specificity and 98.15 cm for men (96% sensitivity, 99.5% specificity. Conclusions. TSCA in the selection of the groups used in ROC curves construction proved to be an important tool, aiding in the detection of MOWN and MHO which cannot be identified with WC alone. The resulting WC cutpoints were <91.00 cm for women and <98.00 cm for men. Furthermore, anthropometry is insufficient to determine healthiness, and, biochemical analysis is needed to properly filter subjects during classification.

  9. Evaluation of bentonite alteration due to interactions with iron. Sensitivity analyses to identify the important factors for the bentonite alteration

    International Nuclear Information System (INIS)

    Sasamoto, Hiroshi; Wilson, James; Sato, Tsutomu

    2013-01-01

    Performance assessment of geological disposal systems for high-level radioactive waste requires a consideration of long-term systems behaviour. It is possible that the alteration of swelling clay present in bentonite buffers might have an impact on buffer functions. In the present study, iron (as a candidate overpack material)-bentonite (I-B) interactions were evaluated as the main buffer alteration scenario. Existing knowledge on alteration of bentonite during I-B interactions was first reviewed, then the evaluation methodology was developed considering modeling techniques previously used overseas. A conceptual model for smectite alteration during I-B interactions was produced. The following reactions and processes were selected: 1) release of Fe 2+ due to overpack corrosion; 2) diffusion of Fe 2+ in compacted bentonite; 3) sorption of Fe 2+ on smectite edge and ion exchange in interlayers; 4) dissolution of primary phases and formation of alteration products. Sensitivity analyses were performed to identify the most important factors for the alteration of bentonite by I-B interactions. (author)

  10. Sensitivity Analyses in Small Break LOCA with HPI-Failure: Effect of Break-Size in Secondary-Side Depressurization

    Science.gov (United States)

    Kinoshita, Ikuo; Torige, Toshihide; Yamada, Minoru

    2014-06-01

    In the case of total failure of the high pressure injection (HPI) system following small break loss of coolant accident (SBLOCA) in pressurized water reactor (PWR), the break size is so small that the primary system does not depressurize to the accumulator (ACC) injection pressure before the core is uncovered extensively. Therefore, steam generator (SG) secondary-side depressurization is necessary as an accident management in order to grant accumulator system actuation and core reflood. A thermal-hydraulic analysis using RELAP5/MOD3 was made on SBLOCA with HPI-failure for Oi Units 3/4 operated by Kansai Electoric Power Co., which are conventional 4 loop PWR plants. The effectiveness of SG secondary-side depressurization procedure was investigated for the real plant design and operational characteristics. The sensitivity analyses using RELAP5/MOD3.2 showed that the accident management was effective for a wide range of break sizes, various orientations and positions. The critical break can be 3 inch cold-leg bottom break.

  11. Sensitivity of Coastal Environments and Wildlife to Spilled Oil: Puget Sound and Strait of Juan de Fuca, Washington: SOCECON (Socioeconomic Resource Points and Lines)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains points that represent the following sensitive human-use socioeconomic sites in Puget Sound and the Strait of Juan de Fuca, Washington: access...

  12. Analysing the Zenith Tropospheric Delay Estimates in On-line Precise Point Positioning (PPP Services and PPP Software Packages

    Directory of Open Access Journals (Sweden)

    Jorge Mendez Astudillo

    2018-02-01

    Full Text Available As Global Navigation Satellite System (GNSS signals travel through the troposphere, a tropospheric delay occurs due to a change in the refractive index of the medium. The Precise Point Positioning (PPP technique can achieve centimeter/millimeter positioning accuracy with only one GNSS receiver. The Zenith Tropospheric Delay (ZTD is estimated alongside with the position unknowns in PPP. Estimated ZTD can be very useful for meteorological applications, an example is the estimation of water vapor content in the atmosphere from the estimated ZTD. PPP is implemented with different algorithms and models in online services and software packages. In this study, a performance assessment with analysis of ZTD estimates from three PPP online services and three software packages is presented. The main contribution of this paper is to show the accuracy of ZTD estimation achievable in PPP. The analysis also provides the GNSS users and researchers the insight of the processing algorithm dependence and impact on PPP ZTD estimation. Observation data of eight whole days from a total of nine International GNSS Service (IGS tracking stations spread in the northern hemisphere, the equatorial region and the southern hemisphere is used in this analysis. The PPP ZTD estimates are compared with the ZTD obtained from the IGS tropospheric product of the same days. The estimates of two of the three online PPP services show good agreement (<1 cm with the IGS ZTD values at the northern and southern hemisphere stations. The results also show that the online PPP services perform better than the selected PPP software packages at all stations.

  13. Modeling Acequia Irrigation Systems Using System Dynamics: Model Development, Evaluation, and Sensitivity Analyses to Investigate Effects of Socio-Economic and Biophysical Feedbacks

    Directory of Open Access Journals (Sweden)

    Benjamin L. Turner

    2016-10-01

    Full Text Available Agriculture-based irrigation communities of northern New Mexico have survived for centuries despite the arid environment in which they reside. These irrigation communities are threatened by regional population growth, urbanization, a changing demographic profile, economic development, climate change, and other factors. Within this context, we investigated the extent to which community resource management practices centering on shared resources (e.g., water for agricultural in the floodplains and grazing resources in the uplands and mutualism (i.e., shared responsibility of local residents to maintaining traditional irrigation policies and upholding cultural and spiritual observances embedded within the community structure influence acequia function. We used a system dynamics modeling approach as an interdisciplinary platform to integrate these systems, specifically the relationship between community structure and resource management. In this paper we describe the background and context of acequia communities in northern New Mexico and the challenges they face. We formulate a Dynamic Hypothesis capturing the endogenous feedbacks driving acequia community vitality. Development of the model centered on major stock-and-flow components, including linkages for hydrology, ecology, community, and economics. Calibration metrics were used for model evaluation, including statistical correlation of observed and predicted values and Theil inequality statistics. Results indicated that the model reproduced trends exhibited by the observed system. Sensitivity analyses of socio-cultural processes identified absentee decisions, cumulative income effect on time in agriculture, and land use preference due to time allocation, community demographic effect, effect of employment on participation, and farm size effect as key determinants of system behavior and response. Sensitivity analyses of biophysical parameters revealed that several key parameters (e.g., acres per

  14. Phenotypic and genetic analyses of the varroa sensitive hygienic trait in Russian honey bee (hymenoptera: apidae) colonies.

    Science.gov (United States)

    Kirrane, Maria J; de Guzman, Lilia I; Holloway, Beth; Frake, Amanda M; Rinderer, Thomas E; Whelan, Pádraig M

    2014-01-01

    Varroa destructor continues to threaten colonies of European honey bees. General hygiene, and more specific Varroa Sensitive Hygiene (VSH), provide resistance towards the Varroa mite in a number of stocks. In this study, 32 Russian (RHB) and 14 Italian honey bee colonies were assessed for the VSH trait using two different assays. Firstly, colonies were assessed using the standard VSH behavioural assay of the change in infestation of a highly infested donor comb after a one-week exposure. Secondly, the same colonies were assessed using an "actual brood removal assay" that measured the removal of brood in a section created within the donor combs as a potential alternative measure of hygiene towards Varroa-infested brood. All colonies were then analysed for the recently discovered VSH quantitative trait locus (QTL) to determine whether the genetic mechanisms were similar across different stocks. Based on the two assays, RHB colonies were consistently more hygienic toward Varroa-infested brood than Italian honey bee colonies. The actual number of brood cells removed in the defined section was negatively correlated with the Varroa infestations of the colonies (r2 = 0.25). Only two (percentages of brood removed and reproductive foundress Varroa) out of nine phenotypic parameters showed significant associations with genotype distributions. However, the allele associated with each parameter was the opposite of that determined by VSH mapping. In this study, RHB colonies showed high levels of hygienic behaviour towards Varroa -infested brood. The genetic mechanisms are similar to those of the VSH stock, though the opposite allele associates in RHB, indicating a stable recombination event before the selection of the VSH stock. The measurement of brood removal is a simple, reliable alternative method of measuring hygienic behaviour towards Varroa mites, at least in RHB stock.

  15. Phenotypic and Genetic Analyses of the Varroa Sensitive Hygienic Trait in Russian Honey Bee (Hymenoptera: Apidae) Colonies

    Science.gov (United States)

    Kirrane, Maria J.; de Guzman, Lilia I.; Holloway, Beth; Frake, Amanda M.; Rinderer, Thomas E.; Whelan, Pádraig M.

    2015-01-01

    Varroa destructor continues to threaten colonies of European honey bees. General hygiene, and more specific Varroa Sensitive Hygiene (VSH), provide resistance towards the Varroa mite in a number of stocks. In this study, 32 Russian (RHB) and 14 Italian honey bee colonies were assessed for the VSH trait using two different assays. Firstly, colonies were assessed using the standard VSH behavioural assay of the change in infestation of a highly infested donor comb after a one-week exposure. Secondly, the same colonies were assessed using an “actual brood removal assay” that measured the removal of brood in a section created within the donor combs as a potential alternative measure of hygiene towards Varroa-infested brood. All colonies were then analysed for the recently discovered VSH quantitative trait locus (QTL) to determine whether the genetic mechanisms were similar across different stocks. Based on the two assays, RHB colonies were consistently more hygienic toward Varroa-infested brood than Italian honey bee colonies. The actual number of brood cells removed in the defined section was negatively correlated with the Varroa infestations of the colonies (r2 = 0.25). Only two (percentages of brood removed and reproductive foundress Varroa) out of nine phenotypic parameters showed significant associations with genotype distributions. However, the allele associated with each parameter was the opposite of that determined by VSH mapping. In this study, RHB colonies showed high levels of hygienic behaviour towards Varroa -infested brood. The genetic mechanisms are similar to those of the VSH stock, though the opposite allele associates in RHB, indicating a stable recombination event before the selection of the VSH stock. The measurement of brood removal is a simple, reliable alternative method of measuring hygienic behaviour towards Varroa mites, at least in RHB stock. PMID:25909856

  16. Variations in shape-sensitive restriction points mirror differences in the regeneration capacities of avian and mammalian ears.

    Directory of Open Access Journals (Sweden)

    Maria Sol Collado

    Full Text Available When inner ear hair cells die, humans and other mammals experience permanent hearing and balance deficits, but non-mammalian vertebrates quickly recover these senses after epithelial supporting cells give rise to replacement hair cells. A postnatal decline in cellular plasticity appears to limit regeneration in mammalian balance organs, where declining proliferation responses are correlated with decreased spreading of supporting cells on artificial and native substrates. By culturing balance epithelia on substrates that differed in flexibility, we assessed spreading effects independent of age, showing a strong correlation between shape change and supporting cell proliferation. Then we made excision wounds in utricles cultured from young and old chickens and mice and compared quantified levels of spreading and proliferation. In utricles from young mice, and both young and old chickens, wounds re-epithelialized in <24 hours, while those in utricles from mature mice took three times longer. More cells changed shape in the fastest healing wounds, which accounted for some differences in the levels of proliferation, but inter-species and age-related differences in shape-sensitive restriction points, i.e., the cellular thresholds for shape changes that promote S-phase, were evident and may be particularly influential in the responses to hair cell losses in vivo.

  17. Influence of Immersion Conditions on The Tensile Strength of Recycled Kevlar®/Polyester/Low-Melting-Point Polyester Nonwoven Geotextiles through Applying Statistical Analyses

    Directory of Open Access Journals (Sweden)

    Jing-Chzi Hsieh

    2016-05-01

    Full Text Available The recycled Kevlar®/polyester/low-melting-point polyester (recycled Kevlar®/PET/LPET nonwoven geotextiles are immersed in neutral, strong acid, and strong alkali solutions, respectively, at different temperatures for four months. Their tensile strength is then tested according to various immersion periods at various temperatures, in order to determine their durability to chemicals. For the purpose of analyzing the possible factors that influence mechanical properties of geotextiles under diverse environmental conditions, the experimental results and statistical analyses are incorporated in this study. Therefore, influences of the content of recycled Kevlar® fibers, implementation of thermal treatment, and immersion periods on the tensile strength of recycled Kevlar®/PET/LPET nonwoven geotextiles are examined, after which their influential levels are statistically determined by performing multiple regression analyses. According to the results, the tensile strength of nonwoven geotextiles can be enhanced by adding recycled Kevlar® fibers and thermal treatment.

  18. Effects of spray and stretch on postneedling soreness and sensitivity after dry needling of a latent myofascial trigger point.

    Science.gov (United States)

    Martín-Pintado Zugasti, Aitor; Rodríguez-Fernández, Ángel L; García-Muro, Francisco; López-López, Almudena; Mayoral, Orlando; Mesa-Jiménez, Juan; Fernández-Carnero, Josue

    2014-10-01

    To investigate (1) the effect of spray and stretch versus control on reducing postneedling soreness of 1 latent myofascial trigger point (MTrP) and (2) whether higher levels of psychological distress are associated with increased postneedling pain intensity. A 72-hour follow-up, single-blind randomized controlled trial. University community. Healthy volunteers (N=70; 40 men, 30 women) aged 18 to 36 years (mean age, 21±4y) with latent MTrP in 1 upper trapezius muscle. All subjects received a dry needling application over the upper trapezius muscle. Then, participants were randomly divided into 2 groups: an intervention group, which received spray and stretch over the needled trapezius muscle, and a control group, which did not receive any intervention. Visual analog scale (at postneedling, posttreatment, and 6, 12, 24, 48, and 72h after needling), pressure pain threshold (at preneedling, postneedling, and 24 and 48h after needling). Psychological distress was evaluated by using the Symptom Checklist-90-Revised. Repeated-measures analysis of variance demonstrated a significant interaction between group and time (F3,204.8=3.19; P.05). Repeated measures of covariance showed that none of the psychological covariates affected these results. Somatization, anxiety, interpersonal sensitivity, and hostility were significantly correlated (P<.05) with postneedling pain intensity. Repeated-measures analysis of variance did not show a significant effect of spray and stretch on mechanical hyperalgesia (F2.6,175=1.9; P=.131; ηp(2)=.02). The spray and stretch had a short-term (<6h) effect in reducing postneedling soreness of a latent MTrP. Pressure pain threshold did not significantly change after spray and stretch. Psychological factors are related to postneedling pain. Copyright © 2014 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

  19. Sensitivities and Tipping Points of Power System Operations to Fluctuations Caused by Water Availability and Fuel Prices

    Science.gov (United States)

    O'Connell, M.; Macknick, J.; Voisin, N.; Fu, T.

    2017-12-01

    The western US electric grid is highly dependent upon water resources for reliable operation. Hydropower and water-cooled thermoelectric technologies represent 67% of generating capacity in the western region of the US. While water resources provide a significant amount of generation and reliability for the grid, these same resources can represent vulnerabilities during times of drought or low flow conditions. A lack of water affects water-dependent technologies and can result in more expensive generators needing to run in order to meet electric grid demand, resulting in higher electricity prices and a higher cost to operate the grid. A companion study assesses the impact of changes in water availability and air temperatures on power operations by directly derating hydro and thermo-electric generators. In this study we assess the sensitivities and tipping points of water availability compared with higher fuel prices in electricity sector operations. We evaluate the impacts of varying electricity prices by modifying fuel prices for coal and natural gas. We then analyze the difference in simulation results between changes in fuel prices in combination with water availability and air temperature variability. We simulate three fuel price scenarios for a 2010 baseline scenario along with 100 historical and future hydro-climate conditions. We use the PLEXOS electricity production cost model to optimize power system dispatch and cost decisions under each combination of fuel price and water constraint. Some of the metrics evaluated are total production cost, generation type mix, emissions, transmission congestion, and reserve procurement. These metrics give insight to how strained the system is, how much flexibility it still has, and to what extent water resource availability or fuel prices drive changes in the electricity sector operations. This work will provide insights into current electricity operations as well as future cases of increased penetration of variable

  20. Understanding N2O formation mechanisms through sensitivity analyses using a plant-wide benchmark simulation model

    DEFF Research Database (Denmark)

    Boiocchi, Riccardo; Gernaey, Krist; Sin, Gürkan

    2017-01-01

    In the present work, sensitivity analyses are performed on a plant-wide model incorporating the typical treatment unit of a full-scale wastewater treatment plant and N2O production and emission dynamics. The influence of operating temperatureis investigated. The results are exploited to identify...

  1. Sensitivity of landscape resistance estimates based on point selection functions to scale and behavioral state: Pumas as a case study

    Science.gov (United States)

    Katherine A. Zeller; Kevin McGarigal; Paul Beier; Samuel A. Cushman; T. Winston Vickers; Walter M. Boyce

    2014-01-01

    Estimating landscape resistance to animal movement is the foundation for connectivity modeling, and resource selection functions based on point data are commonly used to empirically estimate resistance. In this study, we used GPS data points acquired at 5-min intervals from radiocollared pumas in southern California to model context-dependent point selection...

  2. Global Sensitivity and Data-Worth Analyses in iTOUGH2: User's Guide

    Energy Technology Data Exchange (ETDEWEB)

    Wainwright, Haruko Murakami [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Earth Sciences Division; Univ. of California, Berkeley, CA (United States); Finsterle, Stefan [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Earth Sciences Division; Univ. of California, Berkeley, CA (United States)

    2016-07-15

    This manual explains the use of local sensitivity analysis, the global Morris OAT and Sobol’ methods, and a related data-worth analysis as implemented in iTOUGH2. In addition to input specification and output formats, it includes some examples to show how to interpret results.

  3. Thermal threshold and sensitivity of the only symbiotic Mediterranean gorgonian Eunicella singularis by morphometric and genotypic analyses.

    Science.gov (United States)

    Pey, Alexis; Catanéo, Jérôme; Forcioli, Didier; Merle, Pierre-Laurent; Furla, Paola

    2013-07-01

    The only symbiotic Mediterranean gorgonian, Eunicella singularis, has faced several mortality events connected to abnormal high temperatures. Since thermotolerance data remain scarce, heat-induced necrosis was monitored in aquarium by morphometric analysis. Gorgonian tips were sampled at two sites: Medes (Spain) and Riou (France) Islands, and at two depths: -15 m and-35 m. Although coming from contrasting thermal regimes, seawater above 28 °C led to rapid and complete tissue necrosis for all four populations. However, at 27 °C, the time length leading to 50% tissue necrosis allowed us to classify samples within three classes of thermal sensitivity. Irrespectively of the depth, Medes specimens were either very sensitive or resistant, while Riou fragments presented a medium sensitivity. Microsatellite analysis revealed that host and symbiont were genetically differentiated between sites, but not between depths. Finally, these genetic differentiations were not directly correlated to a specific thermal sensitivity whose molecular bases remain to be discovered. Copyright © 2013 Académie des sciences. Published by Elsevier SAS. All rights reserved.

  4. Phenotypic and genetic analyses of the Varroa Sensitive Hygienic trait in Russian Honey Bee (Hymenoptera: Apidae) colonies

    Science.gov (United States)

    Varroa destructor continues to threaten colonies of European honey bees. General hygiene and more specific VarroaVarroa Sensitive Hygiene (VSH) provide resistance toward the Varroa mite in a number of stocks. In this study, Russian (RHB) and Italian honey bees were assessed for the VSH trait. Two...

  5. Analysed a defective of the machine for a cap-tube nuclear fuel element ME-27 from its electricity point of view

    International Nuclear Information System (INIS)

    Achmad Suntoro

    2009-01-01

    It has been analysed a defective of the machine for a cap-tube nuclear fuel element ME-27 from its electricity point of view. The machine uses magnetic force resistance welding technique. A short circuit was happened within the machine because the nut for tightening high voltage cable for welding transformer was broken so that the cable touched the machine body and produced the short circuit. This condition made both the primary circuit breaker in the building down and produced high voltage pulse induction to the electronic circuit within the machine so that one of its electronic components was defective. This case becomes warnings on how important of tightening a nut according to its strength specification (using wrench torque) and the necessity of voltage transient limitation circuit to be installed. Both of the warnings are necessary for any equipment consuming high electric current oriented such as the ME-27 machine. (author)

  6. The march from early life food sensitization to allergic disease: a systematic review and meta-analyses of birth cohort studies.

    Science.gov (United States)

    Alduraywish, S A; Lodge, C J; Campbell, B; Allen, K J; Erbas, B; Lowe, A J; Dharmage, S C

    2016-01-01

    There is growing evidence for an increase in food allergies. The question of whether early life food sensitization, a primary step in food allergies, leads to other allergic disease is a controversial but important issue. Birth cohorts are an ideal design to answer this question. We aimed to systematically investigate and meta-analyse the evidence for associations between early food sensitization and allergic disease in birth cohorts. MEDLINE and SCOPUS databases were searched for birth cohorts that have investigated the association between food sensitization in the first 2 years and subsequent wheeze/asthma, eczema and/or allergic rhinitis. We performed meta-analyses using random-effects models to obtain pooled estimates, stratified by age group. The search yielded fifteen original articles representing thirteen cohorts. Early life food sensitization was associated with an increased risk of infantile eczema, childhood wheeze/asthma, eczema and allergic rhinitis and young adult asthma. Meta-analyses demonstrated that early life food sensitization is related to an increased risk of wheeze/asthma (pooled OR 2.9; 95% CI 2.0-4.0), eczema (pooled OR 2.7; 95% CI 1.7-4.4) and allergic rhinitis (pooled OR 3.1; 95% CI 1.9-4.9) from 4 to 8 years. Food sensitization in the first 2 years of life can identify children at high risk of subsequent allergic disease who may benefit from early life preventive strategies. However, due to potential residual confounding in the majority of studies combined with lack of follow-up into adolescence and adulthood, further research is needed. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  7. Evaluation of habitat suitability index models by global sensitivity and uncertainty analyses: a case study for submerged aquatic vegetation

    Science.gov (United States)

    Zajac, Zuzanna; Stith, Bradley M.; Bowling, Andrea C.; Langtimm, Catherine A.; Swain, Eric D.

    2015-01-01

    Habitat suitability index (HSI) models are commonly used to predict habitat quality and species distributions and are used to develop biological surveys, assess reserve and management priorities, and anticipate possible change under different management or climate change scenarios. Important management decisions may be based on model results, often without a clear understanding of the level of uncertainty associated with model outputs. We present an integrated methodology to assess the propagation of uncertainty from both inputs and structure of the HSI models on model outputs (uncertainty analysis: UA) and relative importance of uncertain model inputs and their interactions on the model output uncertainty (global sensitivity analysis: GSA). We illustrate the GSA/UA framework using simulated hydrology input data from a hydrodynamic model representing sea level changes and HSI models for two species of submerged aquatic vegetation (SAV) in southwest Everglades National Park: Vallisneria americana (tape grass) and Halodule wrightii (shoal grass). We found considerable spatial variation in uncertainty for both species, but distributions of HSI scores still allowed discrimination of sites with good versus poor conditions. Ranking of input parameter sensitivities also varied spatially for both species, with high habitat quality sites showing higher sensitivity to different parameters than low-quality sites. HSI models may be especially useful when species distribution data are unavailable, providing means of exploiting widely available environmental datasets to model past, current, and future habitat conditions. The GSA/UA approach provides a general method for better understanding HSI model dynamics, the spatial and temporal variation in uncertainties, and the parameters that contribute most to model uncertainty. Including an uncertainty and sensitivity analysis in modeling efforts as part of the decision-making framework will result in better-informed, more robust

  8. Evaluation of habitat suitability index models by global sensitivity and uncertainty analyses: a case study for submerged aquatic vegetation.

    Science.gov (United States)

    Zajac, Zuzanna; Stith, Bradley; Bowling, Andrea C; Langtimm, Catherine A; Swain, Eric D

    2015-07-01

    Habitat suitability index (HSI) models are commonly used to predict habitat quality and species distributions and are used to develop biological surveys, assess reserve and management priorities, and anticipate possible change under different management or climate change scenarios. Important management decisions may be based on model results, often without a clear understanding of the level of uncertainty associated with model outputs. We present an integrated methodology to assess the propagation of uncertainty from both inputs and structure of the HSI models on model outputs (uncertainty analysis: UA) and relative importance of uncertain model inputs and their interactions on the model output uncertainty (global sensitivity analysis: GSA). We illustrate the GSA/UA framework using simulated hydrology input data from a hydrodynamic model representing sea level changes and HSI models for two species of submerged aquatic vegetation (SAV) in southwest Everglades National Park: Vallisneria americana (tape grass) and Halodule wrightii (shoal grass). We found considerable spatial variation in uncertainty for both species, but distributions of HSI scores still allowed discrimination of sites with good versus poor conditions. Ranking of input parameter sensitivities also varied spatially for both species, with high habitat quality sites showing higher sensitivity to different parameters than low-quality sites. HSI models may be especially useful when species distribution data are unavailable, providing means of exploiting widely available environmental datasets to model past, current, and future habitat conditions. The GSA/UA approach provides a general method for better understanding HSI model dynamics, the spatial and temporal variation in uncertainties, and the parameters that contribute most to model uncertainty. Including an uncertainty and sensitivity analysis in modeling efforts as part of the decision-making framework will result in better-informed, more robust

  9. Sensitivity of LDEF foil analyses using ultra-low background germanium vs. large NaI(Tl) multidimensional spectrometers

    International Nuclear Information System (INIS)

    Reeves, J.H.; Arthur, R.J.; Brodzinski, R.L.

    1992-06-01

    Cobalt foils and stainless steel samples were analyzed for induced 6O Co activity with both an ultra-low background germanium gamma-ray spectrometer and with a large NaI(Tl) multidimensional spectrometer, both of which use electronic anticoincidence shielding to reduce background counts resulting from cosmic rays. Aluminum samples were analyzed for 22 Na. The results, in addition to the relative sensitivities and precisions afforded by the two methods, are presented

  10. Mise au point sur l’analyse de la régiodistribution en acides gras des triacylglycérols

    Directory of Open Access Journals (Sweden)

    Turon Fabrice

    2003-03-01

    Full Text Available Dans la première partie de cette mise au point sont examinées les deux méthodes usuelles (enzymatique et chimique pour l’analyse de la régiodistribution en acides gras des triacylglycérols. Le but est notamment de montrer les limites de leurs applications ainsi que les problèmes posés par la mise en œuvre des modes opératoires. Dans la deuxième partie de cet exposé, une nouvelle méthode d’analyse de la régiodistribution à partir des α‐monoacylglycérols obtenus par dégradation des triacylglycérols avec un réactif de Grignard est examinée à la lumière des résultats d’une étude théorique faite sur un triacylglycérol modèle.

  11. Evaluating the effect of sample type on American alligator (Alligator mississippiensis) analyte values in a point-of-care blood analyser.

    Science.gov (United States)

    Hamilton, Matthew T; Finger, John W; Winzeler, Megan E; Tuberville, Tracey D

    2016-01-01

    The assessment of wildlife health has been enhanced by the ability of point-of-care (POC) blood analysers to provide biochemical analyses of non-domesticated animals in the field. However, environmental limitations (e.g. temperature, atmospheric humidity and rain) and lack of reference values may inhibit researchers from using such a device with certain wildlife species. Evaluating the use of alternative sample types, such as plasma, in a POC device may afford researchers the opportunity to delay sample analysis and the ability to use banked samples. In this study, we examined fresh whole blood, fresh plasma and frozen plasma (sample type) pH, partial pressure of carbon dioxide (PCO2), bicarbonate (HCO3 (-)), total carbon dioxide (TCO2), base excess (BE), partial pressure of oxygen (PO2), oxygen saturation (sO2) and lactate concentrations in 23 juvenile American alligators (Alligator mississippiensis) using an i-STAT CG4+ cartridge. Our results indicate that sample type had no effect on lactate concentration values (F 2,65 = 0.37, P = 0.963), suggesting that the i-STAT analyser can be used reliably to quantify lactate concentrations in fresh and frozen plasma samples. In contrast, the other seven blood parameters measured by the CG4+ cartridge were significantly affected by sample type. Lastly, we were able to collect blood samples from all alligators within 2 min of capture to establish preliminary reference ranges for juvenile alligators based on values obtained using fresh whole blood.

  12. ESI-VI3 East Point, St. Croix, U.S. Virgin Islands 2000 (Environmental Sensitivity Index Map)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Environmental Sensitivity Index (ESI) maps are an integral component in oil-spill contingency planning and assessment. They serve as a source of information in the...

  13. Stochastic methods for the quantification of sensitivities and uncertainties in criticality analyses; Stochastische Methoden zur Quantifizierung von Sensitivitaeten und Unsicherheiten in Kritikalitaetsanalysen

    Energy Technology Data Exchange (ETDEWEB)

    Behler, Matthias; Bock, Matthias; Stuke, Maik; Wagner, Markus

    2014-06-15

    This work describes statistical analyses based on Monte Carlo sampling methods for criticality safety analyses. The methods analyse a large number of calculations of a given problem with statistically varied model parameters to determine uncertainties and sensitivities of the computed results. The GRS development SUnCISTT (Sensitivities and Uncertainties in Criticality Inventory and Source Term Tool) is a modular, easily extensible abstract interface program, designed to perform such Monte Carlo sampling based uncertainty and sensitivity analyses in the field of criticality safety. It couples different criticality and depletion codes commonly used in nuclear criticality safety assessments to the well-established GRS tool SUSA for sensitivity and uncertainty analyses. For uncertainty analyses of criticality calculations, SunCISTT couples various SCALE sequences developed at Oak Ridge National Laboratory and the general Monte Carlo N-particle transport code MCNP from Los Alamos National Laboratory to SUSA. The impact of manufacturing tolerances of a fuel assembly configuration on the neutron multiplication factor for the various sequences is shown. Uncertainties in nuclear inventories, dose rates, or decay heat can be investigated via the coupling of the GRS depletion system OREST to SUSA. Some results for a simplified irradiated Pressurized Water Reactor (PWR) UO{sub 2} fuel assembly are shown. SUnCISTT also combines the two aforementioned modules for burnup credit criticality analysis of spent nuclear fuel to ensures an uncertainty and sensitivity analysis using the variations of manufacturing tolerances in the burn-up code and criticality code simultaneously. Calculations and results for a storage cask loaded with typical irradiated PWR UO{sub 2} fuel are shown, including Monte Carlo sampled axial burn-up profiles. The application of SUnCISTT in the field of code validation, specifically, how it is applied to compare a simulation model to available benchmark

  14. Sensitivity of Coastal Environments and Wildlife to Spilled Oil: North Carolina: SOCECON (Socioeconomic Resource Points and Lines)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains human-use resource data for abandoned vessels, access points, airports, archaeological sites, artifical reefs, beaches, boat ramps,...

  15. Sensitivity of Coastal Environments and Wildlife to Spilled Oil: Southern California: SOCECON (Socioeconomic Resource Points and Lines)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains human-use resource point data for access sites, airports, aquaculture sites, beaches, boat ramps, marinas, coast guard facilities, oil...

  16. Sensitivity of Coastal Environments and Wildlife to Spilled Oil: Florida Panhandle: SOCECON (Socioeconomic Resource Points and Lines)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains human-use resource data (e.g., abandoned vessels, access points, airports, aquaculture sites, archaeological sites, artificial reefs, beaches,...

  17. Sensitivity of Coastal Environments and Wildlife to Spilled Oil: Upper Coast of Texas: SOCECON (Socioeconomic Resource Points and Lines)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains human-use resource data for access points, aquaculture sites, airports, artificial reefs, boat ramps, coast guard stations, heliports,...

  18. Sensitivity of Coastal Environments and Wildlife to Spilled Oil: South Florida: SOCECON (Socioeconomic Resource Points and Lines)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains human-use resource data for abandoned vessels, access points, airports, aquaculture sites, beaches, boat ramps, coast guard stations, ferries,...

  19. Sensitivity of Coastal Environments and Wildlife to Spilled Oil: Northwest Arctic, Alaska: SOCECON (Socioeconomic Resource Points and Lines)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains vector points and lines representing human-use resource data for airports, marinas, and mining sites in Northwest Arctic, Alaska....

  20. High-resolution linkage analyses to identify genes that influence Varroa sensitive hygiene behavior in honey bees.

    Directory of Open Access Journals (Sweden)

    Jennifer M Tsuruda

    Full Text Available Varroa mites (V. destructor are a major threat to honey bees (Apis melilfera and beekeeping worldwide and likely lead to colony decline if colonies are not treated. Most treatments involve chemical control of the mites; however, Varroa has evolved resistance to many of these miticides, leaving beekeepers with a limited number of alternatives. A non-chemical control method is highly desirable for numerous reasons including lack of chemical residues and decreased likelihood of resistance. Varroa sensitive hygiene behavior is one of two behaviors identified that are most important for controlling the growth of Varroa populations in bee hives. To identify genes influencing this trait, a study was conducted to map quantitative trait loci (QTL. Individual workers of a backcross family were observed and evaluated for their VSH behavior in a mite-infested observation hive. Bees that uncapped or removed pupae were identified. The genotypes for 1,340 informative single nucleotide polymorphisms were used to construct a high-resolution genetic map and interval mapping was used to analyze the association of the genotypes with the performance of Varroa sensitive hygiene. We identified one major QTL on chromosome 9 (LOD score = 3.21 and a suggestive QTL on chromosome 1 (LOD = 1.95. The QTL confidence interval on chromosome 9 contains the gene 'no receptor potential A' and a dopamine receptor. 'No receptor potential A' is involved in vision and olfaction in Drosophila, and dopamine signaling has been previously shown to be required for aversive olfactory learning in honey bees, which is probably necessary for identifying mites within brood cells. Further studies on these candidate genes may allow for breeding bees with this trait using marker-assisted selection.

  1. SURE: a system of computer codes for performing sensitivity/uncertainty analyses with the RELAP code. [PWR

    Energy Technology Data Exchange (ETDEWEB)

    Bjerke, M.A.

    1983-02-01

    A package of computer codes has been developed to perform a nonlinear uncertainty analysis on transient thermal-hydraulic systems which are modeled with the RELAP computer code. Using an uncertainty around the analyses of experiments in the PWR-BDHT Separate Effects Program at Oak Ridge National Laboratory. The use of FORTRAN programs running interactively on the PDP-10 computer has made the system very easy to use and provided great flexibility in the choice of processing paths. Several experiments simulating a loss-of-coolant accident in a nuclear reactor have been successfully analyzed. It has been shown that the system can be automated easily to further simplify its use and that the conversion of the entire system to a base code other than RELAP is possible.

  2. Complex patterns of divergence among green-sensitive (RH2a African cichlid opsins revealed by Clade model analyses

    Directory of Open Access Journals (Sweden)

    Weadick Cameron J

    2012-10-01

    Full Text Available Abstract Background Gene duplications play an important role in the evolution of functional protein diversity. Some models of duplicate gene evolution predict complex forms of paralog divergence; orthologous proteins may diverge as well, further complicating patterns of divergence among and within gene families. Consequently, studying the link between protein sequence evolution and duplication requires the use of flexible substitution models that can accommodate multiple shifts in selection across a phylogeny. Here, we employed a variety of codon substitution models, primarily Clade models, to explore how selective constraint evolved following the duplication of a green-sensitive (RH2a visual pigment protein (opsin in African cichlids. Past studies have linked opsin divergence to ecological and sexual divergence within the African cichlid adaptive radiation. Furthermore, biochemical and regulatory differences between the RH2aα and RH2aβ paralogs have been documented. It thus seems likely that selection varies in complex ways throughout this gene family. Results Clade model analysis of African cichlid RH2a opsins revealed a large increase in the nonsynonymous-to-synonymous substitution rate ratio (ω following the duplication, as well as an even larger increase, one consistent with positive selection, for Lake Tanganyikan cichlid RH2aβ opsins. Analysis using the popular Branch-site models, by contrast, revealed no such alteration of constraint. Several amino acid sites known to influence spectral and non-spectral aspects of opsin biochemistry were found to be evolving divergently, suggesting that orthologous RH2a opsins may vary in terms of spectral sensitivity and response kinetics. Divergence appears to be occurring despite intronic gene conversion among the tandemly-arranged duplicates. Conclusions Our findings indicate that variation in selective constraint is associated with both gene duplication and divergence among orthologs in African

  3. Sensitivity and uncertainty analyses applied to one-dimensional radionuclide transport in a layered fractured rock: Evaluation of the Limit State approach, Iterative Performance Assessment, Phase 2

    International Nuclear Information System (INIS)

    Wu, Y.T.; Gureghian, A.B.; Sagar, B.; Codell, R.B.

    1992-12-01

    The Limit State approach is based on partitioning the parameter space into two parts: one in which the performance measure is smaller than a chosen value (called the limit state), and the other in which it is larger. Through a Taylor expansion at a suitable point, the partitioning surface (called the limit state surface) is approximated as either a linear or quadratic function. The success and efficiency of the limit state method depends upon choosing an optimum point for the Taylor expansion. The point in the parameter space that has the highest probability of producing the value chosen as the limit state is optimal for expansion. When the parameter space is transformed into a standard Gaussian space, the optimal expansion point, known as the lost Probable Point (MPP), has the property that its location on the Limit State surface is closest to the origin. Additionally, the projections onto the parameter axes of the vector from the origin to the MPP are the sensitivity coefficients. Once the MPP is determined and the Limit State surface approximated, formulas (see Equations 4-7 and 4-8) are available for determining the probability of the performance measure being less than the limit state. By choosing a succession of limit states, the entire cumulative distribution of the performance measure can be detemined. Methods for determining the MPP and also for improving the estimate of the probability are discussed in this report

  4. Quantitative analyses reveal distinct sensitivities of the capture of HIV-1 primary viruses and pseudoviruses to broadly neutralizing antibodies.

    Science.gov (United States)

    Kim, Jiae; Jobe, Ousman; Peachman, Kristina K; Michael, Nelson L; Robb, Merlin L; Rao, Mangala; Rao, Venigalla B

    2017-08-01

    Development of vaccines capable of eliciting broadly neutralizing antibodies (bNAbs) is a key goal to controlling the global AIDS epidemic. To be effective, bNAbs must block the capture of HIV-1 to prevent viral acquisition and establishment of reservoirs. However, the role of bNAbs, particularly during initial exposure of primary viruses to host cells, has not been fully examined. Using a sensitive, quantitative, and high-throughput qRT-PCR assay, we found that primary viruses were captured by host cells and converted into a trypsin-resistant form in less than five minutes. We discovered, unexpectedly, that bNAbs did not block primary virus capture, although they inhibited the capture of pseudoviruses/IMCs and production of progeny viruses at 48h. Further, viruses escaped bNAb inhibition unless the bNAbs were present in the initial minutes of exposure of virus to host cells. These findings will have important implications for HIV-1 vaccine design and determination of vaccine efficacy. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  5. Preliminary performance assessment for the Waste Isolation Pilot Plant, December 1992. Volume 5, Uncertainty and sensitivity analyses of gas and brine migration for undisturbed performance

    Energy Technology Data Exchange (ETDEWEB)

    1993-08-01

    Before disposing of transuranic radioactive waste in the Waste Isolation Pilot Plant (WIPP), the United States Department of Energy (DOE) must evaluate compliance with applicable long-term regulations of the United States Environmental Protection Agency (EPA). Sandia National Laboratories is conducting iterative performance assessments (PAs) of the WIPP for the DOE to provide interim guidance while preparing for a final compliance evaluation. This volume of the 1992 PA contains results of uncertainty and sensitivity analyses with respect to migration of gas and brine from the undisturbed repository. Additional information about the 1992 PA is provided in other volumes. Volume 1 contains an overview of WIPP PA and results of a preliminary comparison with 40 CFR 191, Subpart B. Volume 2 describes the technical basis for the performance assessment, including descriptions of the linked computational models used in the Monte Carlo analyses. Volume 3 contains the reference data base and values for input parameters used in consequence and probability modeling. Volume 4 contains uncertainty and sensitivity analyses with respect to the EPA`s Environmental Standards for the Management and Disposal of Spent Nuclear Fuel, High-Level and Transuranic Radioactive Wastes (40 CFR 191, Subpart B). Finally, guidance derived from the entire 1992 PA is presented in Volume 6. Results of the 1992 uncertainty and sensitivity analyses indicate that, conditional on the modeling assumptions and the assigned parameter-value distributions, the most important parameters for which uncertainty has the potential to affect gas and brine migration from the undisturbed repository are: initial liquid saturation in the waste, anhydrite permeability, biodegradation-reaction stoichiometry, gas-generation rates for both corrosion and biodegradation under inundated conditions, and the permeability of the long-term shaft seal.

  6. Updated model for radionuclide transport in the near-surface till at Forsmark - Implementation of decay chains and sensitivity analyses

    Energy Technology Data Exchange (ETDEWEB)

    Pique, Angels; Pekala, Marek; Molinero, Jorge; Duro, Lara; Trinchero, Paolo; Vries, Luis Manuel de [Amphos 21 Consulting S.L., Barcelona (Spain)

    2013-02-15

    The Forsmark area has been proposed for potential siting of a deep underground (geological) repository for radioactive waste in Sweden. Safety assessment of the repository requires radionuclide transport from the disposal depth to recipients at the surface to be studied quantitatively. The near-surface quaternary deposits at Forsmark are considered a pathway for potential discharge of radioactivity from the underground facility to the biosphere, thus radionuclide transport in this system has been extensively investigated over the last years. The most recent work of Pique and co-workers (reported in SKB report R-10-30) demonstrated that in case of release of radioactivity the near-surface sedimentary system at Forsmark would act as an important geochemical barrier, retarding the transport of reactive radionuclides through a combination of retention processes. In this report the conceptual model of radionuclide transport in the quaternary till at Forsmark has been updated, by considering recent revisions regarding the near-surface lithology. In addition, the impact of important conceptual assumptions made in the model has been evaluated through a series of deterministic and probabilistic (Monte Carlo) sensitivity calculations. The sensitivity study focused on the following effects: 1. Radioactive decay of {sup 135}Cs, {sup 59}Ni, {sup 230}Th and {sup 226}Ra and effects on their transport. 2. Variability in key geochemical parameters, such as the composition of the deep groundwater, availability of sorbing materials in the till, and mineral equilibria. 3. Variability in hydraulic parameters, such as the definition of hydraulic boundaries, and values of hydraulic conductivity, dispersivity and the deep groundwater inflow rate. The overarching conclusion from this study is that the current implementation of the model is robust (the model is largely insensitive to variations in the parameters within the studied ranges) and conservative (the Base Case calculations have a

  7. Modification and Validation of the Triglyceride-to-HDL Cholesterol Ratio as a Surrogate of Insulin Sensitivity in White Juveniles and Adults without Diabetes Mellitus: The Single Point Insulin Sensitivity Estimator (SPISE).

    Science.gov (United States)

    Paulmichl, Katharina; Hatunic, Mensud; Højlund, Kurt; Jotic, Aleksandra; Krebs, Michael; Mitrakou, Asimina; Porcellati, Francesca; Tura, Andrea; Bergsten, Peter; Forslund, Anders; Manell, Hannes; Widhalm, Kurt; Weghuber, Daniel; Anderwald, Christian-Heinz

    2016-09-01

    The triglyceride-to-HDL cholesterol (TG/HDL-C) ratio was introduced as a tool to estimate insulin resistance, because circulating lipid measurements are available in routine settings. Insulin, C-peptide, and free fatty acids are components of other insulin-sensitivity indices but their measurement is expensive. Easier and more affordable tools are of interest for both pediatric and adult patients. Study participants from the Relationship Between Insulin Sensitivity and Cardiovascular Disease [43.9 (8.3) years, n = 1260] as well as the Beta-Cell Function in Juvenile Diabetes and Obesity study cohorts [15 (1.9) years, n = 29] underwent oral-glucose-tolerance tests and euglycemic clamp tests for estimation of whole-body insulin sensitivity and calculation of insulin sensitivity indices. To refine the TG/HDL ratio, mathematical modeling was applied including body mass index (BMI), fasting TG, and HDL cholesterol and compared to the clamp-derived M-value as an estimate of insulin sensitivity. Each modeling result was scored by identifying insulin resistance and correlation coefficient. The Single Point Insulin Sensitivity Estimator (SPISE) was compared to traditional insulin sensitivity indices using area under the ROC curve (aROC) analysis and χ(2) test. The novel formula for SPISE was computed as follows: SPISE = 600 × HDL-C(0.185)/(TG(0.2) × BMI(1.338)), with fasting HDL-C (mg/dL), fasting TG concentrations (mg/dL), and BMI (kg/m(2)). A cutoff value of 6.61 corresponds to an M-value smaller than 4.7 mg · kg(-1) · min(-1) (aROC, M:0.797). SPISE showed a significantly better aROC than the TG/HDL-C ratio. SPISE aROC was comparable to the Matsuda ISI (insulin sensitivity index) and equal to the QUICKI (quantitative insulin sensitivity check index) and HOMA-IR (homeostasis model assessment-insulin resistance) when calculated with M-values. The SPISE seems well suited to surrogate whole-body insulin sensitivity from inexpensive fasting single-point blood draw and BMI

  8. Diagnosing acute HIV infection at point of care: a retrospective analysis of the sensitivity and specificity of a fourth-generation point-of-care test for detection of HIV core protein p24.

    Science.gov (United States)

    Fitzgerald, Naomi; Cross, Maria; O'Shea, Siobhan; Fox, Julie

    2017-03-01

    Detection of acute HIV infection is vital in preventing onward transmission. HIV point-of-care testing (POCT) has improved uptake of HIV testing but has been limited to third-generation assays, which only detect chronic HIV infection. Previous evaluation of the fourth-generation Alere Determine HIV-1/2 Ag/Ab Combo POCT showed only 50% sensitivity for HIV core protein p24 (p24 antigen) detection, which is suboptimal for diagnosis of acute HIV infection with limited advantage over third-generation POCT. We aimed to assess the sensitivity of the new Alere HIV Combo POCT to detect acute HIV infection. Stored samples in samples already identified as p24-positive using standard-of-care fourth-generation assays were randomly selected alongside groups of antibody-positive samples and HIV-negative samples. Each sample was tested using the new Alere POCT according to manufacturer's instructions. Sensitivity and specificity were then calculated. The Alere HIV Combo POCT test demonstrated 88% sensitivity 95% CI (78% to 98%) and 100% specificity 95% CI (99.7% to 100%) for detection of p24 antigen. This new POCT shows improved sensitivity for detection of p24 antigen and may be of value for clinical use in detecting acute HIV infection. Further evaluation of its use in a clinical setting is still required. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  9. Global sensitivity analysis of thermo-mechanical models in numerical weld modelling; Analyse de sensibilite globale de modeles thermomecaniques de simulation numerique du soudage

    Energy Technology Data Exchange (ETDEWEB)

    Petelet, M

    2007-10-15

    Current approach of most welding modellers is to content themselves with available material data, and to chose a mechanical model that seems to be appropriate. Among inputs, those controlling the material properties are one of the key problems of welding simulation: material data are never characterized over a sufficiently wide temperature range {exclamation_point} This way to proceed neglect the influence of the uncertainty of input data on the result given by the computer code. In this case, how to assess the credibility of prediction? This thesis represents a step in the direction of implementing an innovative approach in welding simulation in order to bring answers to this question, with an illustration on some concretes welding cases. The global sensitivity analysis is chosen to determine which material properties are the most sensitive in a numerical welding simulation and in which range of temperature. Using this methodology require some developments to sample and explore the input space covering welding of different steel materials. Finally, input data have been divided in two groups according to their influence on the output of the model (residual stress or distortion). In this work, complete methodology of the global sensitivity analysis has been successfully applied to welding simulation and lead to reduce the input space to the only important variables. Sensitivity analysis has provided answers to what can be considered as one of the probable frequently asked questions regarding welding simulation: for a given material which properties must be measured with a good accuracy and which ones can be simply extrapolated or taken from a similar material? (author)

  10. The Relationship between Rate of Algometer Application and Pain Pressure Threshold in the Assessment of Myofascial Trigger Point Sensitivity.

    Science.gov (United States)

    Linde, Lukas D; Kumbhare, Dinesh A; Joshi, Maneil; Srbely, John Z

    2018-02-01

    Pressure algometry is a commonly employed technique in the assessment of both regional and widespread musculoskeletal pain. Despite its acceptance amongst clinicians and scientists, the relationship between rate of pressure application (RoA) and pain pressure threshold (PPT) remains poorly understood. We set out to test the hypothesis that a strong, positive, linear relationship exists between the RoA and the PPT within the infraspinatus of young healthy subjects. Thirty-three participants were randomly recruited from the local university community. PPT measures were recorded from a clinically identified myofascial trigger point within the right infraspinatus muscle during pressure algometry. A total of 2 PPT measures were recorded using each of 3 different RoAs, including low (15 N/s), medium (35 N/s), and high (55 N/s). Three baseline trials were also conducted at 30 N/s. The Pearson's correlation coefficient between RoA and PPT was calculated for each subject and averaged across participants. The mean(SD) correlation between subjects was 0.77 (0.19), and the mean (SD) slope of the linear regression was 0.13 (0.09). Our results demonstrate that there is a strong, linear relationship between the RoA and PPT when using the pressure algometry technique. The low slope between RoA and PPT suggests clinicians can rely on PPT assessments despite small RoA fluctuations. Future research should explore this relationship further in a clinical population and in other muscles affected by chronic myofascial pain. Advancing cost-effective, reliable, and clinically feasible tools such as algometry is important to enhancing the diagnosis and management of chronic myofascial pain. © 2017 World Institute of Pain.

  11. Determination of sensitivity, specificity and cut off point of visual- Motor Bender Gestalt Test in the diagnosis of traumatic brain injury

    Directory of Open Access Journals (Sweden)

    tayebeh Rezaie nasab

    2013-02-01

    Results: In this study, cut-off point was calculated as 6.5%, sensitivity as 55.8%, characteristic as 81.2%, and the area under the Roc curve as 0.69. Moreover, positive predictive value, negative predictive value and efficiency were 95.08%, 22.03%, and 59.17%, respectively. Conclusion: Results of this study revealed that Bender Gestalt Test is relatively weak in diagnosis of mild TBI. Hence, its characteristic is high and it was successful in diagnosing healthy individuals.

  12. Multiple active myofascial trigger points and pressure pain sensitivity maps in the temporalis muscle are related in women with chronic tension type headache.

    Science.gov (United States)

    Fernández-de-las-Peñas, César; Caminero, Ana B; Madeleine, Pascal; Guillem-Mesado, Amparo; Ge, Hong-You; Arendt-Nielsen, Lars; Pareja, Juan A

    2009-01-01

    To describe the common locations of active trigger points (TrPs) in the temporalis muscle and their referred pain patterns in chronic tension type headache (CTTH), and to determine if pressure sensitivity maps of this muscle can be used to describe the spatial distribution of active TrPs. Forty women with CTTH were included. An electronic pressure algometer was used to assess pressure pain thresholds (PPT) from 9 points over each temporalis muscle: 3 points in the anterior, medial and posterior part, respectively. Both muscles were examined for the presence of active TrPs over each of the 9 points. The referred pain pattern of each active TrP was assessed. Two-way analysis of variance detected significant differences in mean PPT levels between the measurement points (F=30.3; P<0.001), but not between sides (F=2.1; P=0.2). PPT scores decreased from the posterior to the anterior column (P<0.001). No differences were found in the number of active TrPs (F=0.3; P=0.9) between the dominant side the nondominant side. Significant differences were found in the distribution of the active TrPs (chi2=12.2; P<0.001): active TrPs were mostly found in the anterior column and in the middle of the muscle belly. The analysis of variance did not detect significant differences in the referred pain pattern between active TrPs (F=1.1, P=0.4). The topographical pressure pain sensitivity maps showed the distinct distribution of the TrPs indicated by locations with low PPTs. Multiple active TrPs in the temporalis muscle were found, particularly in the anterior column and in the middle of the muscle belly. Bilateral posterior to anterior decreased distribution of PPTs in the temporalis muscle in women with CTTH was found. The locations of active TrPs in the temporalis muscle corresponded well to the muscle areas with lower PPT, supporting the relationship between multiple active muscle TrPs and topographical pressure sensitivity maps in the temporalis muscle in women with CTTH.

  13. Rapid, sensitive and reproducible method for point-of-collection screening of liquid milk for adulterants using a portable Raman spectrometer with novel optimized sample well

    Science.gov (United States)

    Nieuwoudt, Michel K.; Holroyd, Steve E.; McGoverin, Cushla M.; Simpson, M. Cather; Williams, David E.

    2017-02-01

    Point-of-care diagnostics are of interest in the medical, security and food industry, the latter particularly for screening food adulterated for economic gain. Milk adulteration continues to be a major problem worldwide and different methods to detect fraudulent additives have been investigated for over a century. Laboratory based methods are limited in their application to point-of-collection diagnosis and also require expensive instrumentation, chemicals and skilled technicians. This has encouraged exploration of spectroscopic methods as more rapid and inexpensive alternatives. Raman spectroscopy has excellent potential for screening of milk because of the rich complexity inherent in its signals. The rapid advances in photonic technologies and fabrication methods are enabling increasingly sensitive portable mini-Raman systems to be placed on the market that are both affordable and feasible for both point-of-care and point-of-collection applications. We have developed a powerful spectroscopic method for rapidly screening liquid milk for sucrose and four nitrogen-rich adulterants (dicyandiamide (DCD), ammonium sulphate, melamine, urea), using a combined system: a small, portable Raman spectrometer with focusing fibre optic probe and optimized reflective focusing wells, simply fabricated in aluminium. The reliable sample presentation of this system enabled high reproducibility of 8% RSD (residual standard deviation) within four minutes. Limit of detection intervals for PLS calibrations ranged between 140 - 520 ppm for the four N-rich compounds and between 0.7 - 3.6 % for sucrose. The portability of the system and reliability and reproducibility of this technique opens opportunities for general, reagentless adulteration screening of biological fluids as well as milk, at point-of-collection.

  14. Sensitivity of the Hydrogen Epoch of Reionization Array and its build-out stages to one-point statistics from redshifted 21 cm observations

    Science.gov (United States)

    Kittiwisit, Piyanat; Bowman, Judd D.; Jacobs, Daniel C.; Beardsley, Adam P.; Thyagarajan, Nithyanandan

    2018-03-01

    We present a baseline sensitivity analysis of the Hydrogen Epoch of Reionization Array (HERA) and its build-out stages to one-point statistics (variance, skewness, and kurtosis) of redshifted 21 cm intensity fluctuation from the Epoch of Reionization (EoR) based on realistic mock observations. By developing a full-sky 21 cm light-cone model, taking into account the proper field of view and frequency bandwidth, utilizing a realistic measurement scheme, and assuming perfect foreground removal, we show that HERA will be able to recover statistics of the sky model with high sensitivity by averaging over measurements from multiple fields. All build-out stages will be able to detect variance, while skewness and kurtosis should be detectable for HERA128 and larger. We identify sample variance as the limiting constraint of the measurements at the end of reionization. The sensitivity can also be further improved by performing frequency windowing. In addition, we find that strong sample variance fluctuation in the kurtosis measured from an individual field of observation indicates the presence of outlying cold or hot regions in the underlying fluctuations, a feature that can potentially be used as an EoR bubble indicator.

  15. Short-term changes in neck pain, widespread pressure pain sensitivity, and cervical range of motion after the application of trigger point dry needling in patients with acute mechanical neck pain: a randomized clinical trial.

    Science.gov (United States)

    Mejuto-Vázquez, María J; Salom-Moreno, Jaime; Ortega-Santiago, Ricardo; Truyols-Domínguez, Sebastián; Fernández-de-Las-Peñas, César

    2014-04-01

    Randomized clinical trial. To determine the effects of trigger point dry needling (TrPDN) on neck pain, widespread pressure pain sensitivity, and cervical range of motion in patients with acute mechanical neck pain and active trigger points in the upper trapezius muscle. TrPDN seems to be effective for decreasing pain in individuals with upper-quadrant pain syndromes. Potential effects of TrPDN for decreasing pain and sensitization in individuals with acute mechanical neck pain are needed. Methods Seventeen patients (53% female) were randomly assigned to 1 of 2 groups: a single session of TrPDN or no intervention (waiting list). Pressure pain thresholds over the C5-6 zygapophyseal joint, second metacarpal, and tibialis anterior muscle; neck pain intensity; and cervical spine range-of-motion data were collected at baseline (pretreatment) and 10 minutes and 1 week after the intervention by an assessor blinded to the treatment allocation of the patient. Mixed-model analyses of variance were used to examine the effects of treatment on each outcome variable. Patients treated with 1 session of TrPDN experienced greater decreases in neck pain, greater increases in pressure pain threshold, and higher increases in cervical range of motion than those who did not receive an intervention at both 10 minutes and 1 week after the intervention (Pneck pain intensity and widespread pressure pain sensitivity, and also increase active cervical range of motion, in patients with acute mechanical neck pain. Changes in pain, pressure pain threshold, and cervical range of motion surpassed their respective minimal detectable change values, supporting clinically relevant treatment effects. Level of Evidence Therapy, level 1b-.

  16. Central Sensitization Is Modulated Following Trigger Point Anesthetization in Patients with Chronic Pain from Whiplash Trauma. A Double-Blind, Placebo-Controlled, Crossover Study.

    Science.gov (United States)

    Nystrom, N Ake; Freeman, Michael D

    2018-01-01

    Central sensitization (CS) with low peripheral pain thresholds (PPTs) is a common finding among patients with chronic pain after whiplash (CPWI). While it has been proposed that myofascial myofascial trigger points (MTrPs) may act as modulators of central sensitization, previously reported findings are conflicting and inconclusive. The present study was designed to investigate immediate responsiveness of CS to alterations in nociceptive input. Controlled, double-blind, cross-over. Thirty-one patients with chronic pain (trapezius myalgia) and CS after whiplash. Participants were referred by randomization to group A for injection of a single peripheral pain generator (MTrP or other discrete tender point) with local anesthetic or to group B for sham injection and cross-over. Documentation of PPT (Algometer), maximum jaw opening (caliper), and grip strength (Vigorimeter), as well as subjective overall pain (visual analog scale [VAS]), was made before and after each intervention. Statistical analysis of data (Student's t test, analysis of variance) confirmed that peripheral pain thresholds were significantly higher and maximum jaw opening significantly greater after anesthetizing a focal pain generator in the trapezius, but not after a sham injection. In contrast with the objective variables, subjective generalized pain improved (VAS) after not only an injection of local anesthetic, but also, and to a similar extent, after a sham injection. CS, as expressed by lowered PPT, is a rapidly adjusting physiological response to nociceptive stimuli in some patients with chronic pain after whiplash. PPT are likely modulated by myofascial tender points in selected patients with CS. With reference to the present findings, surgical ablation of MTrPs is discussed as a potential treatment modality for CS. © 2017 American Academy of Pain Medicine. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com

  17. Rapid and sensitive detection of Feline immunodeficiency virus using an insulated isothermal PCR-based assay with a point-of-need PCR detection platform.

    Science.gov (United States)

    Wilkes, Rebecca Penrose; Kania, Stephen A; Tsai, Yun-Long; Lee, Pei-Yu Alison; Chang, Hsiu-Hui; Ma, Li-Juan; Chang, Hsiao-Fen Grace; Wang, Hwa-Tang Thomas

    2015-07-01

    Feline immunodeficiency virus (FIV) is an important infectious agent of cats. Clinical syndromes resulting from FIV infection include immunodeficiency, opportunistic infections, and neoplasia. In our study, a 5' long terminal repeat/gag region-based reverse transcription insulated isothermal polymerase chain reaction (RT-iiPCR) was developed to amplify all known FIV strains to facilitate point-of-need FIV diagnosis. The RT-iiPCR method was applied in a point-of-need PCR detection platform--a field-deployable device capable of generating automatically interpreted RT-iiPCR results from nucleic acids within 1 hr. Limit of detection 95% of FIV RT-iiPCR was calculated to be 95 copies standard in vitro transcription RNA per reaction. Endpoint dilution studies with serial dilutions of an ATCC FIV type strain showed that the sensitivity of lyophilized FIV RT-iiPCR reagent was comparable to that of a reference nested PCR. The established reaction did not amplify any nontargeted feline pathogens, including Felid herpesvirus 1, feline coronavirus, Feline calicivirus, Feline leukemia virus, Mycoplasma haemofelis, and Chlamydophila felis. Based on analysis of 76 clinical samples (including blood and bone marrow) with the FIV RT-iiPCR, test sensitivity was 97.78% (44/45), specificity was 100.00% (31/31), and agreement was 98.65% (75/76), determined against a reference nested-PCR assay. A kappa value of 0.97 indicated excellent correlation between these 2 methods. The lyophilized FIV RT-iiPCR reagent, deployed on a user-friendly portable device, has potential utility for rapid and easy point-of-need detection of FIV in cats. © 2015 The Author(s).

  18. Optimal production lot size and reorder point of a two-stage supply chain while random demand is sensitive with sales teams' initiatives

    Science.gov (United States)

    Sankar Sana, Shib

    2016-01-01

    The paper develops a production-inventory model of a two-stage supply chain consisting of one manufacturer and one retailer to study production lot size/order quantity, reorder point sales teams' initiatives where demand of the end customers is dependent on random variable and sales teams' initiatives simultaneously. The manufacturer produces the order quantity of the retailer at one lot in which the procurement cost per unit quantity follows a realistic convex function of production lot size. In the chain, the cost of sales team's initiatives/promotion efforts and wholesale price of the manufacturer are negotiated at the points such that their optimum profits reached nearer to their target profits. This study suggests to the management of firms to determine the optimal order quantity/production quantity, reorder point and sales teams' initiatives/promotional effort in order to achieve their maximum profits. An analytical method is applied to determine the optimal values of the decision variables. Finally, numerical examples with its graphical presentation and sensitivity analysis of the key parameters are presented to illustrate more insights of the model.

  19. Sensitivity of Multiangle, Multispectral Polarimetric Remote Sensing Over Open Oceans to Water-Leaving Radiance: Analyses of RSP Data Acquired During the MILAGRO Campaign

    Science.gov (United States)

    Chowdhary, Jacek; Cairns, Brian; Waquet, Fabien; Knobelspiesse, Kirk; Ottaviani, Matteo; Redemann, Jens; Travis, Larry; Mishchenko, Michael

    2012-01-01

    For remote sensing of aerosol over the ocean, there is a contribution from light scattered underwater. The brightness and spectrum of this light depends on the biomass content of the ocean, such that variations in the color of the ocean can be observed even from space. Rayleigh scattering by pure sea water, and Rayleigh-Gans type scattering by plankton, causes this light to be polarized with a distinctive angular distribution. To study the contribution of this underwater light polarization to multiangle, multispectral observations of polarized reflectance over ocean, we previously developed a hydrosol model for use in underwater light scattering computations that produces realistic variations of the ocean color and the underwater light polarization signature of pure sea water. In this work we review this hydrosol model, include a correction for the spectrum of the particulate scattering coefficient and backscattering efficiency, and discuss its sensitivity to variations in colored dissolved organic matter (CDOM) and in the scattering function of marine particulates. We then apply this model to measurements of total and polarized reflectance that were acquired over open ocean during the MILAGRO field campaign by the airborne Research Scanning Polarimeter (RSP). Analyses show that our hydrosol model faithfully reproduces the water-leaving contributions to RSP reflectance, and that the sensitivity of these contributions to Chlorophyll a concentration [Chl] in the ocean varies with the azimuth, height, and wavelength of observations. We also show that the impact of variations in CDOM on the polarized reflectance observed by the RSP at low altitude is comparable to or much less than the standard error of this reflectance whereas their effects in total reflectance may be substantial (i.e. up to >30%). Finally, we extend our study of polarized reflectance variations with [Chl] and CDOM to include results for simulated spaceborne observations.

  20. Point of Care Tuberculosis Sero-Diagnosis Kit for Wild Animals: Combination of Proteins for Improving the Diagnostic Sensitivity and Specificity.

    Science.gov (United States)

    Veerasami, Maroudam; Venkataraman, K; Karuppannan, Chitra; Shanmugam, Arun Attur; Prudhvi, Mallepaddi Chand; Holder, Thomas; Rathnagiri, Polavarapu; Arunmozhivarman, K; Raj, Gopal Dhinakar; Vordermeier, Martin; Mohana Subramanian, B

    2018-03-01

    Tuberculosis is a significant problem globally for domestic animals as well as captive and free ranging wild life. Rapid point of care (POC) serology kits are well suited for the diagnosis of TB in wild animals. However, wild animals are invariably exposed to environmental non-pathogenic mycobacterium species with the development of cross reacting antibodies. In the present study, POC TB diagnosis kit was developed using a combination of pathogenic Mycobacteria specific recombinant antigens and purified protein derivatives of pathogenic and non-pathogenic Mycobacteria . To benchmark the TB antibody detection kit, particularly in respect to specificity which could not be determined in wildlife due to the lack of samples from confirmed uninfected animals, we first tested well-characterized sera from 100 M. bovis infected and 100 uninfected cattle. Then we investigated the kit's performance using sera samples from wildlife, namely Sloth Bears (n = 74), Elephants (n = 9), Cervidae (n = 14), Felidae (n = 21), Cape buffalo (n = 2), Wild bear (n = 1) and Wild dog (n = 1).In cattle, a sensitivity of 81% and a specificity of 90% were obtained. The diagnostic sensitivity of the kit was 94% when the kit was tested using known TB positive sloth bear sera samples. 47.4% of the in-contact sloth bears turned seropositive using the rapid POC TB diagnostic kit. Seropositivity in other wild animals was 25% when the sera samples were tested using the kit. A point of care TB sero-diagnostic kit with the combination of proteins was developed and the kit was validated using the sera samples of wild animals.

  1. Sensitivity analysis of non-point sources in a water quality model applied to a dammed low-flow-reach river.

    Science.gov (United States)

    Silva, Nayana G M; von Sperling, Marcos

    2008-01-01

    Downstream of Capim Branco I hydroelectric dam (Minas Gerais state, Brazil), there is the need of keeping a minimum flow of 7 m3/s. This low flow reach (LFR) has a length of 9 km. In order to raise the water level in the low flow reach, the construction of intermediate dikes along the river bed was decided. The LFR has a tributary that receives the discharge of treated wastewater. As part of this study, water quality of the low-flow reach was modelled, in order to gain insight into its possible behaviour under different scenarios (without and with intermediate dikes). QUAL2E equations were implemented in FORTRAN code. The model takes into account point-source pollution and diffuse pollution. Uncertainty analysis was performed, presenting probabilistic results and allowing identification of the more important coefficients in the LFR water-quality model. The simulated results indicate, in general, very good conditions for most of the water quality parameters The variables of more influence found in the sensitivity analysis were the conversion coefficients (without and with dikes), the initial conditions in the reach (without dikes), the non-point incremental contributions (without dikes) and the hydraulic characteristics of the reach (with dikes). (c) IWA Publishing 2008.

  2. Semi-quantitative and simulation analyses of effects of {gamma} rays on determination of calibration factors of PET scanners with point-like {sup 22}Na sources

    Energy Technology Data Exchange (ETDEWEB)

    Hasegawa, Tomoyuki [School of Allied Health Sciences, Kitasato University, 1-15-1, Kitasato, Minamiku, Sagamihara, Kanagawa, 252-0373 (Japan); Sato, Yasushi [National Institute of Advanced Industrial Science and Technology, 1-1-1, Umezono, Tsukuba, Ibaraki, 305-8568 (Japan); Oda, Keiichi [Tokyo Metropolitan Institute of Gerontology, 1-1, Nakamachi, Itabashi, Tokyo, 173-0022 (Japan); Wada, Yasuhiro [RIKEN Center for Molecular Imaging Science, 6-7-3, Minamimachi, Minatoshima, Chuo, Kobe, Hyogo, 650-0047 (Japan); Murayama, Hideo [National Institute of Radiological Sciences, 4-9-1, Anagawa, Inage, Chiba, 263-8555 (Japan); Yamada, Takahiro, E-mail: hasegawa@kitasato-u.ac.jp [Japan Radioisotope Association, 2-28-45, Komagome, Bunkyo-ku, Tokyo, 113-8941 (Japan)

    2011-09-21

    The uncertainty of radioactivity concentrations measured with positron emission tomography (PET) scanners ultimately depends on the uncertainty of the calibration factors. A new practical calibration scheme using point-like {sup 22}Na radioactive sources has been developed. The purpose of this study is to theoretically investigate the effects of the associated 1.275 MeV {gamma} rays on the calibration factors. The physical processes affecting the coincidence data were categorized in order to derive approximate semi-quantitative formulae. Assuming the design parameters of some typical commercial PET scanners, the effects of the {gamma} rays as relative deviations in the calibration factors were evaluated by semi-quantitative formulae and a Monte Carlo simulation. The relative deviations in the calibration factors were less than 4%, depending on the details of the PET scanners. The event losses due to rejecting multiple coincidence events of scattered {gamma} rays had the strongest effect. The results from the semi-quantitative formulae and the Monte Carlo simulation were consistent and were useful in understanding the underlying mechanisms. The deviations are considered small enough to correct on the basis of precise Monte Carlo simulation. This study thus offers an important theoretical basis for the validity of the calibration method using point-like {sup 22}Na radioactive sources.

  3. Tmc1 Point Mutation Affects Ca2+ Sensitivity and Block by Dihydrostreptomycin of the Mechanoelectrical Transducer Current of Mouse Outer Hair Cells.

    Science.gov (United States)

    Corns, Laura F; Johnson, Stuart L; Kros, Corné J; Marcotti, Walter

    2016-01-13

    The transduction of sound into electrical signals depends on mechanically sensitive ion channels in the stereociliary bundle. The molecular composition of this mechanoelectrical transducer (MET) channel is not yet known. Transmembrane channel-like protein isoforms 1 (TMC1) and 2 (TMC2) have been proposed to form part of the MET channel, although their exact roles are still unclear. Using Beethoven (Tmc1(Bth/Bth)) mice, which have an M412K point mutation in TMC1 that adds a positive charge, we found that Ca(2+) permeability and conductance of the MET channel of outer hair cells (OHCs) were reduced. Tmc1(Bth/Bth) OHCs were also less sensitive to block by the permeant MET channel blocker dihydrostreptomycin, whether applied extracellularly or intracellularly. These findings suggest that the amino acid that is mutated in Bth is situated at or near the negatively charged binding site for dihydrostreptomycin within the permeation pore of the channel. We also found that the Ca(2+) dependence of the operating range of the MET channel was altered by the M412K mutation. Depolarization did not increase the resting open probability of the MET current of Tmc1(Bth/Bth) OHCs, whereas raising the intracellular concentration of the Ca(2+) chelator BAPTA caused smaller increases in resting open probability in Bth mutant OHCs than in wild-type control cells. We propose that these observations can be explained by the reduced Ca(2+) permeability of the mutated MET channel indirectly causing the Ca(2+) sensor for adaptation, at or near the intracellular face of the MET channel, to become more sensitive to Ca(2+) influx as a compensatory mechanism. In the auditory system, the hair cells convert sound-induced mechanical movement of the hair bundles atop these cells into electrical signals through the opening of mechanically gated ion channels at the tips of the bundles. Although the nature of these mechanoelectrical transducer (MET) channels is still unclear, recent studies implicate

  4. Uncertainty and Sensitivity Analyses for CFD Codes: an Attempt of a State of the Art on the Basis of the CEA Experience

    International Nuclear Information System (INIS)

    Crecy, Agnes de; Bazin, Pascal

    2013-01-01

    Uncertainty and sensitivity analyses, associated to best-estimate calculations become paramount for licensing processes and are known as BEPU (Best-Estimate Plus Uncertainties) methods. A recent activity such as the BEMUSE benchmark has shown that the present methods are mature enough for the system thermal-hydraulics codes, even if issues such as the quantification of the uncertainties of the input parameters, and especially, the physical models must be improved. But CFD codes are more and more used for fine 3-D modeling such as, for example, those necessary in dilution or stratification problems. The application of the BEPU methods to CFD codes becomes an issue that must be now addressed. That is precisely the goal of this paper. It consists of two main parts. In the chapter 2, the specificities of CFD codes for BEPU methods are listed, with focuses on the possible difficulties. In the chapter 3, the studies performed at CEA are described. It is important to note that CEA research in this field is only beginning and must not be viewed as a reference approach. (authors)

  5. Substantial Variability Exists in Utilities' Nuclear Decommissioning Funding Adequacy: Baseline Trends (1997-2001); and Scenario and Sensitivity Analyses (Year 2001)

    International Nuclear Information System (INIS)

    Williams, D. G.

    2003-01-01

    This paper explores the trends over 1997-2001 in my baseline simulation analysis of the sufficiency of electric utilities' funds to eventually decommission the nation's nuclear power plants. Further, for 2001, I describe the utilities' funding adequacy results obtained using scenario and sensitivity analyses, respectively. In this paper, I focus more on the wide variability observed in these adequacy measures among utilities than on the results for the ''average'' utility in the nuclear industry. Only individual utilities, not average utilities -- often used by the nuclear industry to represent its funding adequacy -- will decommission their nuclear plants. Industry-wide results tend to mask the varied results for individual utilities. This paper shows that over 1997-2001, the variability of my baseline decommissioning funding adequacy measures (in percentages) for both utility fund balances and current contributions has remained very large, reflected in the sizable ranges and frequency distributions of these percentages. The relevance of this variability for nuclear decommissioning funding adequacy is, of course, focused more on those utilities that show below ideal balances and contribution levels. Looking backward, 42 of 67 utility fund (available) balances, in 2001, were above (and 25 below) their ideal baseline levels; in 1997, 42 of 76 were above (and 34 below) ideal levels. Of these, many utility balances were far above, and many far below, such ideal levels. The problem of certain utilities continuing to show balances much below ideal persists even with increases in the adequacy of ''average'' utility balances

  6. Onset of slugging criterion based on singular points and stability analyses of transient one-dimensional two-phase flow equations of two-fluid model

    International Nuclear Information System (INIS)

    Sung, Chang Kyung; Chun, Moon Hyun

    1996-01-01

    A two-step approach has been used to obtain a new criterion for the onset of slug formation : (1) In the first step, a more general expression than the existing models for the onset of slug flow criterion has been derived from the analysis of singular points and neutral stability conditions of the transient one-dimensional two-phase flow equations of two-fluid model. (2) In the second step, introducing simplifications and incorporating a parameter into the general expression obtained in the first step to satisfy a number of physical conditions a priori specified, a new simple criterion for the onset of slug flow has been derived. Comparisons of the present model with existing models and experimental data show that the present model agree very closely with Taitel and Dukler's model and experimental data in horizontal pipes. In an inclined pipe (θ=50 deg ), however, the difference between the predictions of the present model and those of existing models is appreciably large and the present model gives the best agreement with Ohnuki et al.'s data. 17 refs., 5 figs., 1 tab. (author)

  7. A New Method for Blood NT-proBNP Determination Based on a Near-infrared Point of Care Testing Device with High Sensitivity and Wide Scope.

    Science.gov (United States)

    Zhang, Xiao Guang; Shu, Yao Gen; Gao, Ju; Wang, Xuan; Liu, Li Peng; Wang, Meng; Cao, Yu Xi; Zeng, Yi

    2017-06-01

    To develop a rapid, highly sensitive, and quantitative method for the detection of NT-proBNP levels based on a near-infrared point-of-care diagnostic (POCT) device with wide scope. The lateral flow assay (LFA) strip of NT-proBNP was first prepared to achieve rapid detection. Then, the antibody pairs for NT-proBNP were screened and labeled with the near-infrared fluorescent dye Dylight-800. The capture antibody was fixed on a nitrocellulose membrane by a scribing device. Serial dilutions of serum samples were prepared using NT-proBNP-free serum series. The prepared test strips, combined with a near-infrared POCT device, were validated by known concentrations of clinical samples. The POCT device gave the output of the ratio of the intensity of the fluorescence signal of the detection line to that of the quality control line. The relationship between the ratio value and the concentration of the specimen was plotted as a work curve. The results of 62 clinical specimens obtained from our method were compared in parallel with those obtained from the Roche E411 kit. Based on the log-log plot, the new method demonstrated that there was a good linear relationship between the ratio value and NT-proBNP concentrations ranging from 20 pg/mL to 10 ng/mL. The results of the 62 clinical specimens measured by our method showed a good linear correlation with those measured by the Roche E411 kit. The new LFA detection method of NT-proBNP levels based on the near-infrared POCT device was rapid and highly sensitive with wide scope and was thus suitable for rapid and early clinical diagnosis of cardiac impairment. Copyright © 2017 The Editorial Board of Biomedical and Environmental Sciences. Published by China CDC. All rights reserved.

  8. ANÁLISIS DEL RIESGO DE INCENDIOS FORESTALES: UN ENFOQUE BASADO EN PROCESOS PUNTUALES // FOREST WILDFIRE HAZARD ANALYSES: A POINT PROCESSES APPROACH

    Directory of Open Access Journals (Sweden)

    Rafael González de Gouveia

    2017-06-01

    Full Text Available Los procesos estocásticos puntuales representan una herramienta de gran utilidad para el análisis de los factores de riesgo en los incendios forestales. En este artículo se estudia la ocurrencia de los incendios forestales a partir de un proceso de Poisson espacio temporal, en el que se considera la función de intensidad del mismo como una caracterización del riesgo de incendio a partir de técnicas paramétricas y no paramétricas. Finalmente, se considera un conjunto de datos reales, suministrados por el Ministerio del Poder Popular para el Ambiente a través del Instituto Nacional de Meteorología e Hidrología (INAMEH en Venezuela, relativos a los incendios forestales producidos en un día en particular. Se estiman las funciones de riesgo basadas en el modelo propuesto y se generan mapas de riesgo de incendios lo cuales se ajustan a las características geográficas y climáticas del país. // Point stochastic processes represent a very useful tool for the analysis of hazard factors in wildfire. In this article, the occurrence of wildfire is studied from a spatial-temporal Poisson process, in which the intensity function thereof is considered as a wildfire hazard characterization based on parametric and non-parametric techniques. Finally, it is considered a set of real data, provided by the Ministerio del Poder Popular para el Ambiente from Instituto Nacional de Meteorología e Hidrologia (INAMEH of Venezuela, relating to widlfire produced on a particular day. The hazard functions are estimated based on the proposed model and wildfire hazard maps are generated, which are adjusted to the geographical and climatic characteristics of the country.

  9. Comparative study of reference points by dosimetric analyses for late complications after uniform external radiotherapy and high-dose-rate brachytherapy for cervical cancer

    International Nuclear Information System (INIS)

    Chen, S.-W.; Liang, J.-A.; Yeh, L.-S.; Yang, S.-N.; Shiau, A.-C.; Lin, F.-J.

    2004-01-01

    Purpose: This study aimed to correlate and compare the predictive values of rectal and bladder reference doses of uniform external beam radiotherapy without shielding and high-dose-rate intracavitary brachytherapy (HDRICB) with late sequelae in patients with uterine cervical cancer. Methods and materials: Between September 1992 and December 1998, 154 patients who survived more than 12 months after treatment were studied. Initially, they were treated with 10-MV X-rays (44 to 45 Gy/22 to 25 fractions over 4 to 5 weeks) to the whole pelvis, after which HDRICB was performed using 192 Ir remote afterloading at 1-week intervals for 4 weeks. The standard prescribed dose for each HDRICB was 6.0 Gy to point A. Patient- and treatment-related-factors were evaluated for late rectal complications using logistic regression modeling. Results: The probability of rectal complications showed better correlation of dose-response with increasing total ICRU (International Committee on Radiotherapy Units and Measurements) rectal dose. Multivariate logistic regression demonstrated a high risk of late rectal sequelae in patients who developed rectal complications (p 0.0001;relative risk, 15.06;95% CI, 2.89∼43.7) and total ICRU rectal dose greater than 16 Gy (p = 0.02;relative risk, 2.07;95% CI, 1.13∼4.55). The high risk factors for bladder complications were seen in patients who developed rectal complications (p = 0.0001;relative risk, 15.2;95% CI, 2.81∼44.9) and total ICRU bladder dose greater than 24 Gy (p = 0.02;relative risk, 8.93;95% CI, 1.79∼33.1). Conclusion: This study demonstrated the predictive value of ICRU rectal and bladder reference dosing in HDRICB for patients receiving uniform external beam radiation therapy without central shielding. Patients who had a total ICRU rectal dose greater than 16 Gy, or a total ICRU bladder dose over 24 Gy, were at risk of late sequelae

  10. Curie-point depths estimated from fractal spectral analyses of magnetic anomalies in the western United States and northeast Pacific Oecan

    Science.gov (United States)

    Wang, J.; Li, C.

    2011-12-01

    We estimate Curie-point depths (Zb) of the western United States and northeast Pacific Ocean by analyzing radially averaged amplitude spectra of magnetic anomalies based on a fractal magnetization model. The amplitude spectrum of source magnetization is proportional to the wavenumber (k) raised to a fractal exponent (-β). We first test whether long-wavelength components are captured appropriately by using variable overlapping windows ranging in sizes from 75 × 75 km2 to 200 × 200 km2. For each sliding window, the amplitude spectrum is pre-multiplied with the factor k-β prior to computation. We then use the centroid method (Tanaka et al., 1999) to calculate Zb. We find that when the window size approaches 200 × 200 km2 the resolution of estimated Zb is too low to reveal important geological features. For our study, fractal exponents larger than 0.6 will result in overcorrection. Considering the difficulty of simultaneous inversion of the depths to the top and centroid of magnetic sources (Zt and Z0 respectively) and β, we fix β = 0.5 for the whole study area. Note that β here is defined for amplitude spectrum, which is equivalent to 1 for power spectrum of 2D magnetic sources. Our results show that the estimated Curie depths range from 4 km to 40 km. The average Zb in the northern part of the northeast Pacific Ocean is about 14 km below the sea level, and almost the same depths are found in the junction of the active and ancient Cascade arcs and remanent track of Yellowstone hotspot. Subduction beneath the North American plate and consequent magmatism can account for small Zb in the above mentioned volcanic arc regions. The Mendocino Triple Junction separates the northeast Pacific into northern (mainly consisting of the Explorer, Juan de Fuca and Gorda plates) and southern parts. Both the Zb and the thickness of magnetic layer in the southern part are larger than those in the northern part. This contrast is due to the fact that the Pacific plate to the south

  11. Sensitivity of predictions in an effective model: Application to the chiral critical end point position in the Nambu-Jona-Lasinio model

    International Nuclear Information System (INIS)

    Biguet, Alexandre; Hansen, Hubert; Brugiere, Timothee; Costa, Pedro; Borgnat, Pierre

    2015-01-01

    The measurement of the position of the chiral critical end point (CEP) in the QCD phase diagram is under debate. While it is possible to predict its position by using effective models specifically built to reproduce some of the features of the underlying theory (QCD), the quality of the predictions (e.g., the CEP position) obtained by such effective models, depends on whether solving the model equations constitute a well- or ill-posed inverse problem. Considering these predictions as being inverse problems provides tools to evaluate if the problem is ill-conditioned, meaning that infinitesimal variations of the inputs of the model can cause comparatively large variations of the predictions. If it is ill-conditioned, it has major consequences because of finite variations that could come from experimental and/or theoretical errors. In the following, we shall apply such a reasoning on the predictions of a particular Nambu-Jona-Lasinio model within the mean field + ring approximations, with special attention to the prediction of the chiral CEP position in the (T-μ) plane. We find that the problem is ill-conditioned (i.e. very sensitive to input variations) for the T-coordinate of the CEP, whereas, it is well-posed for the μ-coordinate of the CEP. As a consequence, when the chiral condensate varies in a 10MeV range, μ CEP varies far less. As an illustration to understand how problematic this could be, we show that the main consequence when taking into account finite variation of the inputs, is that the existence of the CEP itself cannot be predicted anymore: for a deviation as low as 0.6% with respect to vacuum phenomenology (well within the estimation of the first correction to the ring approximation) the CEP may or may not exist. (orig.)

  12. Bayesian change-point analyses in ecology

    Science.gov (United States)

    Brian Bekcage; Lawrence Joseph; Patrick Belisle; David B. Wolfson; William J. Platt

    2007-01-01

    Ecological and biological processes can change from one state to another once a threshold has been crossed in space or time. Threshold responses to incremental changes in underlying variables can characterize diverse processes from climate change to the desertification of arid lands from overgrazing.

  13. Effects of Environmental Enrichment on Nicotine Sensitization in Rats Neonatally Treated with Quinpirole: Analyses of Glial Cell Line-Derived Neurotrophic Factor and Implications towards Schizophrenia.

    Science.gov (United States)

    Brown, Russell W; Schlitt, Marjorie A; Owens, Alex S; DePreter, Caitlynn C; Cummins, Elizabeth D; Kirby, Seth L; Gill, W Drew; Burgess, Katherine C

    2018-01-01

    The current study analyzed the effects of environmental enrichment versus isolation housing on the behavioral sensitization to nicotine in the neonatal quinpirole (NQ; dopamine D2-like agonist) model of dopamine D2 receptor supersensitivity, a rodent model of schizophrenia. NQ treatment in rats increases dopamine D2 receptor sensitivity throughout the animal's lifetime, consistent with schizophrenia. Animals were administered NQ (1 mg/kg) or saline (NS) from postnatal day (P)1 to P21, weaned, and immediately placed into enriched housing or isolated in wire cages throughout the experiment. Rats were behaviorally sensitized to nicotine (0.5 mg/kg base) or saline every consecutive day from P38 to P45, and brain tissue was harvested at P46. Results revealed that neither housing condition reduced nicotine sensitization in NQ rats, whereas enrichment reduced sensitization to nicotine in NS-treated animals. The nucleus accumbens (NAcc) was analyzed for glial cell line-derived neurotrophic factor (GDNF), a neurotrophin important in dopamine plasticity. Results were complex, and revealed that NAcc GDNF was increased in animals given nicotine, regardless of housing condition. Further, enrichment increased GDNF in NQ rats regardless of adolescent drug treatment and in NS-treated rats given nicotine, but did not increase GDNF in NS-treated controls compared to the isolated housing condition. This study demonstrates that environmental experience has a prominent impact on the behavioral and the neural plasticity NAcc response to nicotine in adolescence. © 2018 S. Karger AG, Basel.

  14. Utility of ultrasound assisted-cloud point extraction and spectophotometry as a preconcentration and determination tool for the sensitive quantification of mercury species in fish samples

    Science.gov (United States)

    Altunay, Nail

    2018-01-01

    The current study reports, for the first time, the development of a new analytical method employing ultrasound assisted-cloud point extraction (UA-CPE) for the extraction of CH3Hg+ and Hg2 + species from fish samples. Detection and quantification of mercury species were performed at 550 nm by spectrophotometry. The analytical variables affecting complex formation and extraction efficiency were extensively evaluated and optimized by univariate method. Due to behave 14-fold more sensitive and selective of thiophene 2,5-dicarboxylic acid (H2TDC) to Hg2 + ions than CH3Hg+ in presence of mixed surfactant, Tween 20 and SDS at pH 5.0, the amounts of free Hg2 + and total Hg were spectrophotometrically established at 550 nm by monitoring Hg2 + in the pretreated- and extracted-fish samples in ultrasonic bath to speed up extraction using diluted acid mixture (1:1:1, v/v, 4 mol L- 1 HNO3, 4 mol L- 1 HCl, and 0.5 mol L- 1 H2O2), before and after pre-oxidation with permanganate in acidic media. The amount of CH3Hg+ was calculated from difference between total Hg and Hg2 + amounts. The UA-CPE method showed to be suitable for the extraction and determination of mercury species in certified reference materials. The results were in a good agreement (with Student's t-test at 95% confidence limit) with the certified values, and the relative standard deviation was lower than 3.2%. The limits of detection have been 0.27 and 1.20 μg L- 1, for Hg2 + from aqueous calibration solutions and matrix-matched calibration solutions spiked before digestion, respectively, while it is 2.43 μg L- 1 for CH3Hg+ from matrix-matched calibration solutions. A significant matrix effect was not observed from comparison of slopes of both calibration curves, so as to represent the sample matrix. The method was applied to fish samples for speciation analysis of Hg2 + and CH3Hg+. In terms of speciation, while total Hg is detected in range of 2.42-32.08 μg kg- 1, the distribution of mercury in fish were in

  15. The Groningen Longitudinal Glaucoma Study. I. Baseline sensitivity and specificity of the frequency doubling perimeter and the GDx nerve fibre analyser

    NARCIS (Netherlands)

    Heeg, GP; Blanksma, LJ; Hardus, PLLJ; Jansonius, NM

    Purpose: To describe the baseline data of a large cohort of patients included for follow-up with perimetry using the frequency doubling technique (FDT) and with quantification of the retinal nerve fibre layer as assessed by GDx, and to calculate the sensitivity and specificity of both devices from

  16. Estimation of strain sensitivity of seismic velocity changes using the Earth tide: Analyses of seismic small array data at Izu-Oshima volcano, Japan

    Science.gov (United States)

    Takano, T.; Nishimura, T.; Nakahara, H.; Ueda, H.; Fujita, E.

    2017-12-01

    Seismic velocity changes in the crust and/or subsurface have been often observed in association with the occurrences of earthquakes or volcanic activities. Mechanisms of the velocity changes are, for example, non-linear behavior of subsurface, strain changes, ground water level changes etc. To examine the effects of strain changes, the solid earth tide is a good input signal because the strain sensitivity of velocity changes can be measured at many places by using seismic interferometry [Takano et al., 2014; Hillers et al., 2015]. However, there are few reports which detect the velocity changes due to the Earth tide by seismic interferometry. The aim of this study is to estimate the strain sensitivity of velocity changes using the Earth tide at Izu-Oshima volcano, where the small seismic array and seismic network are deployed. We analyze the ambient noises recorded at the seismic array operated by NIED. The array consists of 7 short-period sensors with a diameter of 100 m. The continuous data from 1 Apr. 2014 to 1 Apr. 2015 is analyzed. The tidal strain is extracted from the raw data of the strain-meter deployed by JMA using Baytap-08 [Tamura et al., 1991]. We estimate the velocity changes due to the Earth tide as follows. First, we divide the observation period into five episodes: dilatational and contractional, according to volumetric strain values. CCFs of ambient noise at 2 - 4 Hz are separately stacked for each divided episode. Subsequently, we measure the velocity changes by calculating the phase delay between stacked CCFs at lapse time of less than 6 s. It is recognized that seismic velocity decreases during the dilatational episode with respect to the contractional episode. Strain sensitivity of seismic velocity changes, which is obtained by averaging for six station pairs, is estimated to be (-1.6±0.5)×104 strain-1. The strain sensitivity of the seismic velocity changes is consistent with that at the foot of Mt. Iwate [Takano et al., 2014]. We also

  17. Global sensitivity analysis of thermomechanical models in modelling of welding; Analyse de sensibilite globale de modeles thermomecanique de simulation numerique du soudage

    Energy Technology Data Exchange (ETDEWEB)

    Petelet, M

    2008-07-01

    Current approach of most welding modellers is to content themselves with available material data, and to chose a mechanical model that seems to be appropriate. Among inputs, those controlling the material properties are one of the key problems of welding simulation: material data are never characterized over a sufficiently wide temperature range. This way to proceed neglect the influence of the uncertainty of input data on the result given by the computer code. In this case, how to assess the credibility of prediction? This thesis represents a step in the direction of implementing an innovative approach in welding simulation in order to bring answers to this question, with an illustration on some concretes welding cases.The global sensitivity analysis is chosen to determine which material properties are the most sensitive in a numerical welding simulation and in which range of temperature. Using this methodology require some developments to sample and explore the input space covering welding of different steel materials. Finally, input data have been divided in two groups according to their influence on the output of the model (residual stress or distortion). In this work, complete methodology of the global sensitivity analysis has been successfully applied to welding simulation and lead to reduce the input space to the only important variables. Sensitivity analysis has provided answers to what can be considered as one of the probable frequently asked questions regarding welding simulation: for a given material which properties must be measured with a good accuracy and which ones can be simply extrapolated or taken from a similar material? (author)

  18. Whole genome and transcriptome analyses of environmental antibiotic sensitive and multi-resistant Pseudomonas aeruginosa isolates exposed to waste water and tap water.

    Science.gov (United States)

    Schwartz, Thomas; Armant, Olivier; Bretschneider, Nancy; Hahn, Alexander; Kirchen, Silke; Seifert, Martin; Dötsch, Andreas

    2015-01-01

    The fitness of sensitive and resistant Pseudomonas aeruginosa in different aquatic environments depends on genetic capacities and transcriptional regulation. Therefore, an antibiotic-sensitive isolate PA30 and a multi-resistant isolate PA49 originating from waste waters were compared via whole genome and transcriptome Illumina sequencing after exposure to municipal waste water and tap water. A number of different genomic islands (e.g. PAGIs, PAPIs) were identified in the two environmental isolates beside the highly conserved core genome. Exposure to tap water and waste water exhibited similar transcriptional impacts on several gene clusters (antibiotic and metal resistance, genetic mobile elements, efflux pumps) in both environmental P. aeruginosa isolates. The MexCD-OprJ efflux pump was overexpressed in PA49 in response to waste water. The expression of resistance genes, genetic mobile elements in PA49 was independent from the water matrix. Consistently, the antibiotic sensitive strain PA30 did not show any difference in expression of the intrinsic resistance determinants and genetic mobile elements. Thus, the exposure of both isolates to polluted waste water and oligotrophic tap water resulted in similar expression profiles of mentioned genes. However, changes in environmental milieus resulted in rather unspecific transcriptional responses than selected and stimuli-specific gene regulation. © 2014 The Authors. Microbial Biotechnology published by John Wiley & Sons Ltd and Society for Applied Microbiology.

  19. Sensitivity of Coastal Environments and Wildlife to Spilled Oil: Puget Sound and Strait of Juan de Fuca, Washington: NESTS (Nest Points)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains sensitive biological resource data for bald eagle, great blue heron, and seabird nesting sites in Puget Sound and Strait of Juan de Fuca,...

  20. Sensitivity of Coastal Environments and Wildlife to Spilled Oil: Puget Sound and Strait of Juan de Fuca, Washington: M_MAMPT (Marine Mammal Points)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains sensitive biological resource data for sea otters, sea lions, and harbor seals in Puget Sound and Strait of Juan de Fuca, Washington. Vector...

  1. Deterministic sensitivity analysis for the numerical simulation of contaminants transport; Analyse de sensibilite deterministe pour la simulation numerique du transfert de contaminants

    Energy Technology Data Exchange (ETDEWEB)

    Marchand, E

    2007-12-15

    The questions of safety and uncertainty are central to feasibility studies for an underground nuclear waste storage site, in particular the evaluation of uncertainties about safety indicators which are due to uncertainties concerning properties of the subsoil or of the contaminants. The global approach through probabilistic Monte Carlo methods gives good results, but it requires a large number of simulations. The deterministic method investigated here is complementary. Based on the Singular Value Decomposition of the derivative of the model, it gives only local information, but it is much less demanding in computing time. The flow model follows Darcy's law and the transport of radionuclides around the storage site follows a linear convection-diffusion equation. Manual and automatic differentiation are compared for these models using direct and adjoint modes. A comparative study of both probabilistic and deterministic approaches for the sensitivity analysis of fluxes of contaminants through outlet channels with respect to variations of input parameters is carried out with realistic data provided by ANDRA. Generic tools for sensitivity analysis and code coupling are developed in the Caml language. The user of these generic platforms has only to provide the specific part of the application in any language of his choice. We also present a study about two-phase air/water partially saturated flows in hydrogeology concerning the limitations of the Richards approximation and of the global pressure formulation used in petroleum engineering. (author)

  2. Production and repair of chromosome damage in an X-ray sensitive CHO mutant visualized and analysed in interphase using the technique of premature chromosome condensation

    International Nuclear Information System (INIS)

    Iliakis, G.E.; Pantelias, G.E.

    1990-01-01

    Production of chromosome damage per unit of absorbed radiation dose was in xrs-5 cells larger by a factor of 2.6 than in CHO cells (5.2 breaks per cell per Gy). Changes in chromatin structure, associated with the radiation-sensitive pheno-type of xrs-5 cells, that increase the probability of conversion of a DNA double-strand break (dsb) to a chromosome break are invoked to explain this. Repair of chromosome breaks as measured in plateau-phase G 1 cells was deficient in xrs-5 cells and the number of residual chromosome breaks practically identical to the number of lethal lesions calculated from survival data, suggesting that non-repaired chromosome breaks are likely to be manifestations of lethal events in the cell. The yield of ring chromosomes scored after a few hours of repair was higher by a factor of three in xrs-5 compared with CHO cells. (author)

  3. Improving the Sensitivity and Functionality of Mobile Webcam-Based Fluorescence Detectors for Point-of-Care Diagnostics in Global Health

    Directory of Open Access Journals (Sweden)

    Reuven Rasooly

    2016-05-01

    Full Text Available Resource-poor countries and regions require effective, low-cost diagnostic devices for accurate identification and diagnosis of health conditions. Optical detection technologies used for many types of biological and clinical analysis can play a significant role in addressing this need, but must be sufficiently affordable and portable for use in global health settings. Most current clinical optical imaging technologies are accurate and sensitive, but also expensive and difficult to adapt for use in these settings. These challenges can be mitigated by taking advantage of affordable consumer electronics mobile devices such as webcams, mobile phones, charge-coupled device (CCD cameras, lasers, and LEDs. Low-cost, portable multi-wavelength fluorescence plate readers have been developed for many applications including detection of microbial toxins such as C. Botulinum A neurotoxin, Shiga toxin, and S. aureus enterotoxin B (SEB, and flow cytometry has been used to detect very low cell concentrations. However, the relatively low sensitivities of these devices limit their clinical utility. We have developed several approaches to improve their sensitivity presented here for webcam based fluorescence detectors, including (1 image stacking to improve signal-to-noise ratios; (2 lasers to enable fluorescence excitation for flow cytometry; and (3 streak imaging to capture the trajectory of a single cell, enabling imaging sensors with high noise levels to detect rare cell events. These approaches can also help to overcome some of the limitations of other low-cost optical detection technologies such as CCD or phone-based detectors (like high noise levels or low sensitivities, and provide for their use in low-cost medical diagnostics in resource-poor settings.

  4. A mechanistic model of H{sub 2}{sup 18}O and C{sup 18}OO fluxes between ecosystems and the atmosphere: Model description and sensitivity analyses

    Energy Technology Data Exchange (ETDEWEB)

    Riley, W.J.; Still, C.J.; Torn, M.S.; Berry, J.A.

    2002-01-01

    The concentration of 18O in atmospheric CO2 and H2O is a potentially powerful tracer of ecosystem carbon and water fluxes. In this paper we describe the development of an isotope model (ISOLSM) that simulates the 18O content of canopy water vapor, leaf water, and vertically resolved soil water; leaf photosynthetic 18OC16O (hereafter C18OO) fluxes; CO2 oxygen isotope exchanges with soil and leaf water; soil CO2 and C18OO diffusive fluxes (including abiotic soil exchange); and ecosystem exchange of H218O and C18OO with the atmosphere. The isotope model is integrated into the land surface model LSM, but coupling with other models should be straightforward. We describe ISOLSM and apply it to evaluate (a) simplified methods of predicting the C18OO soil-surface flux; (b) the impacts on the C18OO soil-surface flux of the soil-gas diffusion coefficient formulation, soil CO2 source distribution, and rooting distribution; (c) the impacts on the C18OO fluxes of carbonic anhydrase (CA) activity in soil and leaves; and (d) the sensitivity of model predictions to the d18O value of atmospheric water vapor and CO2. Previously published simplified models are unable to capture the seasonal and diurnal variations in the C18OO soil-surface fluxes simulated by ISOLSM. Differences in the assumed soil CO2 production and rooting depth profiles, carbonic anhydrase activity in soil and leaves, and the d18O value of atmospheric water vapor have substantial impacts on the ecosystem CO2 flux isotopic composition. We conclude that accurate prediction of C18OO ecosystem fluxes requires careful representation of H218O and C18OO exchanges and transport in soils and plants.

  5. Outliers affecting cardiac troponin I measurement: comparison of a new high sensitivity assay with a contemporary assay on the Abbott ARCHITECT analyser.

    Science.gov (United States)

    Sawyer, Nicola; Blennerhassett, John; Lambert, Ramon; Sheehan, Paul; Vasikaran, Samuel D

    2014-07-01

    False-positive cardiac troponin (Tn) results caused by outliers have been reported on various analytical platforms. We have compared the precision profile and outlier rate of the Abbott Diagnostics contemporary troponin I (TnI) assay with their high sensitivity (hs) TnI assay. Three studies were conducted over a 10-month period using routine patients' samples. TnI was measured in duplicate using the contemporary TnI assay in Study 1 and Study 2 (n = 7011 and 7089) and the hs-TnI assay in Study 3 (n = 1522). Critical outliers were defined as duplicate results whose absolute difference exceeded a critical difference (CD = z x √2 x SDAnalytical) at a probability level of 0.0005, with one of the results on the opposite side of the decision limit to its partner. The TnI concentration at 10% imprecision (coefficient of variation) for the contemporary TnI assay was 0.034 µg/L (Study 1) and 0.042 µg/L (Study 2), and 0.006 µg/L (6 ng/L) for the hs-TnI assay. The critical outlier rates for the contemporary TnI assay were 0.51% (Study 1) and 0.37% (Study 2) using a cut-off of 0.04 µg/L, and 0% for the hs-TnI assay using gender-specific cut-offs. The significant number of critical outliers detected using the contemporary TnI assay may pose a risk for misclassification of patients. By contrast, no critical outliers were detected using the hs-TnI assay. However, the total outlier rates for both assays were significantly higher than the expected variability of either assay. The cause of these outliers remains unclear. © The Author(s) 2013 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

  6. Sensitivity analysis of groundwater flow

    International Nuclear Information System (INIS)

    Bao Yungbing

    1990-12-01

    A sensitivity analysis of general linear and nonlinear simulation equation sets is developed in this study in order to facilitate the application of the sensitivity analysis to groundwater flow problems. Two methods are considered for the sensitivity calculation: the 'direct method' and the 'adjoint method'. Sensitivity theory was used to establish a sensitivity analysis model for general three dimensional transient groundwater flow. Three different methods for calculation of the sensitivity coefficient are presented. The sensitivity equations and the groundwater flow equations were nummerically solved by the Galerkin finite element method in the model. Sensitivity coefficients were carried out both numerically with the developed direct method and with the known analytic solution. Very good agreement between the two solutions was obtained. The developed sensitivity model was applied to three dimensional (axi-symmetric) groundwater flow in a tunnel system, which was supposed to be located at a depth of 500 meters below the ground surface in a four-layered rock formation. In this case, the sensitivity distribution of the piezometric head was calculated with the direct method and the sensitivity of multiple performance functions to perturbations of the permeability were analysed by using the adjoint method. The calculations results showed that the peaks of the sensitivity coefficients appear mostly in the area around the tunnel. The piezometric head at the studied points (nodes) was quite sensitive to perturbations of the permeability in the layer where the points were located, but practically insensitive to perturbations of the permeability in the bottom layer. The flux into the tunnel and the velocity performance were mostly sensitive to perturbation of the permeability in the layer next to the top layer, but practically insensitive to perturbation of the permeability in the bottom layer. (author)

  7. Behavioral and molecular analyses of olfaction-mediated avoidance responses of Rana (Lithobates) catesbeiana tadpoles: Sensitivity to thyroid hormones, estrogen, and treated municipal wastewater effluent.

    Science.gov (United States)

    Heerema, Jody L; Jackman, Kevin W; Miliano, Rachel C; Li, Linda; Zaborniak, Tristan S M; Veldhoen, Nik; van Aggelen, Graham; Parker, Wayne J; Pyle, Gregory G; Helbing, Caren C

    2017-10-04

    Olfaction is critical for survival, facilitating predator avoidance and food location. The nature of the olfactory system changes during amphibian metamorphosis as the aquatic herbivorous tadpole transitions to a terrestrial, carnivorous frog. Metamorphosis is principally dependent on the action of thyroid hormones (THs), l-thyroxine (T 4 ) and 3,5,3'-triiodothyronine (T 3 ), yet little is known about their influence on olfaction during this phase of postembryonic development. We exposed Taylor Kollros stage I-XIII Rana (Lithobates) catesbeiana tadpoles to physiological concentrations of T 4 , T 3 , or 17-beta-estradiol (E 2 ) for 48h and evaluated a predator cue avoidance response. The avoidance response in T 3 -exposed tadpoles was abolished while T 4 - or E 2 -exposed tadpoles were unaffected compared to control tadpoles. qPCR analyses on classic TH-response gene transcripts (thra, thrb, and thibz) in the olfactory epithelium demonstrated that, while both THs produced molecular responses, T 3 elicited greater responses than T 4 . Municipal wastewater feed stock was spiked with a defined pharmaceutical and personal care product (PPCP) cocktail and treated with an anaerobic membrane bioreactor (AnMBR). Despite substantially reduced PPCP levels, exposure to this effluent abolished avoidance behavior relative to AnMBR effluent whose feed stock was spiked with vehicle. Thibz transcript levels increased upon exposure to either effluent indicating TH mimic activity. The present work is the first to demonstrate differential TH responsiveness of the frog tadpole olfactory system with both behavioral and molecular alterations. A systems-based analysis is warranted to further elucidate the mechanism of action on the olfactory epithelium and identify further molecular bioindicators linked to behavioral response disruption. Copyright © 2017 Elsevier Inc. All rights reserved.

  8. Mutation analyses in 17 patients with deficiency in acid beta-galactosidase: three novel point mutations and high correlation of mutation W273L with Morquio disease type B.

    Science.gov (United States)

    Paschke, E; Milos, I; Kreimer-Erlacher, H; Hoefler, G; Beck, M; Hoeltzenbein, M; Kleijer, W; Levade, T; Michelakakis, H; Radeva, B

    2001-08-01

    An inherited deficiency in beta-galactosidase can result in GM1 gangliosidosis, with several phenotypes of generalized or chronic psychomotor deterioration, as well as in Morquio disease type B, a characteristic mucopolysaccharidosis free of neurological symptoms. We performed mutation analyses in 17 juvenile and adult patients from various European regions with a deficiency in beta-galactosidase and skeletal abnormalities. Fifteen of these had the Morquio B phenotype and have remained neurologically healthy until now while the two others exhibited psychomotor retardation of juvenile onset. A two-base substitution (851-852TG-->CT; W273L) was present in 14 of the 15 Morquio B cases. Even if one excludes alleles from patients with possible common descent, there was a much higher frequency (79%) among those with Morquio B phenotype for the W273L mutation than previously reported in the literature (37%). That the Morquio phenotype is also expressed in heterozygotes for W273L and alleles typically found in GM1 gangliosidosis makes it possible to predict the phenotype and reliably detect heterozygotes. A single French patient had a novel missense point mutation (Q408P) together with a known mutation (T500A) while the mentally retarded patients were both heterozygous for two mutations known in chronic GM1 gangliosidosis together with two novel missense point mutations (Y270D and H281Y) in the vicinity of W273L. Our results confirm the high impact of Trp 273 for the function of beta-galactosidase and the expression of the Morquio B phenotype. In addition, a second domain around the amino acids 400-500 may also be of significance.

  9. Area under the curve predictions of dalbavancin, a new lipoglycopeptide agent, using the end of intravenous infusion concentration data point by regression analyses such as linear, log-linear and power models.

    Science.gov (United States)

    Bhamidipati, Ravi Kanth; Syed, Muzeeb; Mullangi, Ramesh; Srinivas, Nuggehally

    2018-02-01

    1. Dalbavancin, a lipoglycopeptide, is approved for treating gram-positive bacterial infections. Area under plasma concentration versus time curve (AUC inf ) of dalbavancin is a key parameter and AUC inf /MIC ratio is a critical pharmacodynamic marker. 2. Using end of intravenous infusion concentration (i.e. C max ) C max versus AUC inf relationship for dalbavancin was established by regression analyses (i.e. linear, log-log, log-linear and power models) using 21 pairs of subject data. 3. The predictions of the AUC inf were performed using published C max data by application of regression equations. The quotient of observed/predicted values rendered fold difference. The mean absolute error (MAE)/root mean square error (RMSE) and correlation coefficient (r) were used in the assessment. 4. MAE and RMSE values for the various models were comparable. The C max versus AUC inf exhibited excellent correlation (r > 0.9488). The internal data evaluation showed narrow confinement (0.84-1.14-fold difference) with a RMSE regression models, a single time point strategy of using C max (i.e. end of 30-min infusion) is amenable as a prospective tool for predicting AUC inf of dalbavancin in patients.

  10. The sensitivity of modeled ozone to the temporal distribution of point, area, and mobile source emissions in the eastern United States

    Science.gov (United States)

    Castellanos, Patricia; Stehr, Jeffrey W.; Dickerson, Russell R.; Ehrman, Sheryl H.

    Ozone remains one of the most recalcitrant air pollution problems in the US. Hourly emissions fields used in air quality models (AQMs) generally show less temporal variability than corresponding measurements from continuous emissions monitors (CEM) and field campaigns would imply. If emissions control scenarios to reduce emissions at peak ozone forming hours are to be assessed with AQMs, the effect of emissions' daily variability on modeled ozone must be understood. We analyzed the effects of altering all anthropogenic emissions' temporal distributions by source group on 2002 summer-long simulations of ozone using the Community Multiscale Air Quality Model (CMAQ) v4.5 and the Carbon Bond IV (CBIV) chemical mechanism with 12 km resolution. We find that when mobile source emissions were made constant over the course of a day, 8-h maximum ozone predictions changed by ±7 parts per billion by volume (ppbv) in many urban areas on days when ozone concentrations greater than 80 ppbv were simulated in the base case. Increasing the temporal variation of point sources resulted in ozone changes of +6 and -6 ppbv, but only for small areas near sources. Changing the daily cycle of mobile source emissions produces substantial changes in simulated ozone, especially in urban areas at night; results suggest that shifting the emissions of NO x from day to night, for example in electric powered vehicles recharged at night, could have beneficial impacts on air quality.

  11. Climate Sensitivity

    Energy Technology Data Exchange (ETDEWEB)

    Lindzen, Richard [M.I.T.

    2011-11-09

    Warming observed thus far is entirely consistent with low climate sensitivity. However, the result is ambiguous because the sources of climate change are numerous and poorly specified. Model predictions of substantial warming aredependent on positive feedbacks associated with upper level water vapor and clouds, but models are notably inadequate in dealing with clouds and the impacts of clouds and water vapor are intimately intertwined. Various approaches to measuring sensitivity based on the physics of the feedbacks will be described. The results thus far point to negative feedbacks. Problems with these approaches as well as problems with the concept of climate sensitivity will be described.

  12. On-line complexation/cloud point preconcentration for the sensitive determination of dysprosium in urine by flow injection inductively coupled plasma-optical emission spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Ortega, Claudia; Cerutti, Soledad; Silva, Maria F. [Departamento de Quimica Analitica, Facultad de Quimica, Bioquimica y Farmacia, Universidad Nacional de San Luis, Chacabuco y Pedernera, 5700, San Luis (Argentina); Olsina, Roberto A.; Martinez, Luis D. [Departamento de Quimica Analitica, Facultad de Quimica, Bioquimica y Farmacia, Universidad Nacional de San Luis, Chacabuco y Pedernera, 5700, San Luis (Argentina); Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET), Avda. Rivadavia 1917, CP C1033AAJJ, Buenos Aires (Argentina)

    2003-01-01

    An on-line dysprosium preconcentration and determination system based on the hyphenation of cloud point extraction (CPE) to flow injection analysis (FIA) associated with ICP-OES was studied. For the preconcentration of dysprosium, a Dy(III)-2-(5-bromo-2-pyridylazo)-5-diethylaminophenol complex was formed on-line at pH 9.22 in the presence of nonionic micelles of PONPE-7.5. The micellar system containing the complex was thermostated at 30 C in order to promote phase separation, and the surfactant-rich phase was retained in a microcolumn packed with cotton at pH 9.2. The surfactant-rich phase was eluted with 4 mol L{sup -1} nitric acid at a flow rate of 1.5 mL min{sup -1}, directly in the nebulizer of the plasma. An enhancement factor of 50 was obtained for the preconcentration of 50 mL of sample solution. The detection limit value for the preconcentration of 50 mL of aqueous solution of Dy was 0.03 {mu}g L{sup -1}. The precision for 10 replicate determinations at the 2.0 {mu}g L{sup -1}Dy level was 2.2% relative standard deviation (RSD), calculated from the peak heights obtained. The calibration graph using the preconcentration system for dysprosium was linear with a correlation coefficient of 0.9994 at levels near the detection limits up to at least 100 {mu}g L {sup -1}. The method was successfully applied to the determination of dysprosium in urine. (orig.)

  13. Tipping Point

    Medline Plus

    Full Text Available ... en español Blog About OnSafety CPSC Stands for Safety The Tipping Point Home > 60 Seconds of Safety (Videos) > The Tipping Point The Tipping Point by ... danger death electrical fall furniture head injury product safety television tipover tv Watch the video in Adobe ...

  14. Sensitive analyses of neutral N-glycans using anion-doped liquid matrix G3CA by negative-ion matrix-assisted laser desorption/ionization mass spectrometry.

    Science.gov (United States)

    Nishikaze, Takashi; Fukuyama, Yuko; Kawabata, Shin-ichirou; Tanaka, Koichi

    2012-07-17

    Negative-ion fragmentation of N-glycans has been proven to be more informative than that of positive-ion. In particular, it defines structural features such as the specific composition of the two antennae and the location of fucose. However, negative-ion formation of neutral N-glycans by matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) remains a challenging task, and the detection limit of N-glycans in negative-ion mode is merely at the subpicomole level. Thus, practical applications are limited. In this study, combinations of five liquid matrices and nine anions were used to ionize N-glycans as anionic adducts, and their performances for sensitive analyses were evaluated. The best results were obtained with anion-doped liquid matrix G(3)CA, which consists of p-coumaric acid and 1,1,3,3-tetramethylguanidine; the detection limits of anion adducted N-glycans were 1 fmol/well for NO(3)(-), and 100 amol/well for BF(4)(-). Negative-ion MS(2) spectra of 1 fmol N-glycans were successfully acquired with a sufficient signal-to-noise ratio and were quite useful for MS-based structural determination. The anion-doped G(3)CA matrix opens the way for sensitive and rapid analysis of neutral N-glycans in negative-ion MALDI at a low femtomole level.

  15. High-sensitivity matrix-assisted laser desorption/ionization Fourier transform mass spectrometry analyses of small carbohydrates and amino acids using oxidized carbon nanotubes prepared by chemical vapor deposition as matrix.

    Science.gov (United States)

    Wang, Cui-hong; Li, Jian; Yao, Sheng-jun; Guo, Yin-long; Xia, Xing-hua

    2007-12-05

    In matrix-assisted laser desorption/ionization (MALDI) Fourier transform mass spectrometry (FTMS) analyses of small oligosaccharides and amino acids, high sensitivities for oligosaccharides (10 fmol) were obtained by introducing oxidized carbon nanotubes (CNTs) with short and open-end structure as valuable matrix. The CNTs were deposited in porous anodic alumina (PAA) templates by chemical vapor deposition. Transmission electron microscopy (TEM) images show that those CNTs include low levels of amorphous carbon. Thus, the background interference signals generally caused by amorphous carbon powder in CNTs can be reduced effectively. Experiments also confirmed that the FTMS signal intensity of CNTs prepared in PAA template is much lower than that of commercial multi-wall carbon nanotubes (MCNTs). Moreover, the purified process for CNTs with mixed acid (H2SO4 and HNO3) also contributed to the minimization of background. Intense signals corresponding to alkali cation adduct of neutral carbohydrates and amino acids have been acquired. In addition, reliable quantitative analyses for urine and corn root were also achieved successfully. The present work will open a new way to the application of oxidized CNTs as an effective matrix in MALDI MS research.

  16. Sensitivity analyses of underground drift temperature, stresses, and safety factors to variation in the rock mass properties of tuff for a nuclear waste repository located at Yucca Mountain, Nevada

    International Nuclear Information System (INIS)

    Ehgartner, B.L.

    1987-05-01

    Preliminary two-dimensional thermal and thermal/mechanical sensitivity analyses of the design of the horizontal emplacement drift were performed for times out to 100 years after waste emplacement. The purpose of the analyses is to provide insight into the relative importance of the thermal and thermal/mechanical properties that impact the stability of the emplacement drift-specifically, heat capacity, conductivity, thermal expansion, insitu thermal gradient, insitu stress, joint cohesion and friction angle, elastic modulus, Poisson's ratio, rock friction angle, rock compressive and tensile strength. This will help prioritize future characterization and analysis activities prior to development. The model input properties were varied over the expected range of their values and the corresponding effect on the temperature, stresses, and safety factors of the rock mass surrounding the drift were recorded. First, the properties were varied individually to determine the independent effects on drift performance. Second, select properties were varied simultaneously to assess joint effects and estimate the probability of undesired drift performance. The results represent a first attempt to estimate the variability of the properties and their effects on the drift. Other sources of variability that can affect drift design are not considered, hence the results are considered preliminary. As site characterization proceeds, the enhanced understanding of property variability will lead to updating the results and conclusions of this report. 15 refs., 2 figs., 8 tabs

  17. Tipping Point

    Medline Plus

    Full Text Available ... OnSafety CPSC Stands for Safety The Tipping Point Home > 60 Seconds of Safety (Videos) > The Tipping Point ... 24 hours a day. For young children whose home is a playground, it’s the best way to ...

  18. Fixed Points

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 5; Issue 5. Fixed Points - From Russia with Love - A Primer of Fixed Point Theory. A K Vijaykumar. Book Review Volume 5 Issue 5 May 2000 pp 101-102. Fulltext. Click here to view fulltext PDF. Permanent link:

  19. Fast and highly sensitive fiber-enhanced Raman spectroscopic monitoring of molecular H2 and CH4 for point-of-care diagnosis of malabsorption disorders in exhaled human breath.

    Science.gov (United States)

    Hanf, Stefan; Bögözi, Timea; Keiner, Robert; Frosch, Torsten; Popp, Jürgen

    2015-01-20

    Breath gas analysis is a novel powerful technique for noninvasive, early-stage diagnosis of metabolic disorders or diseases. Molecular hydrogen and methane are biomarkers for colonic fermentation, because of malabsorption of oligosaccharides (e.g., lactose or fructose) and for small intestinal bacterial overgrowth. Recently, the presence of these gases in exhaled breath was also correlated with obesity. Here, we report on the highly selective and sensitive detection of molecular hydrogen and methane within a complex gas mixture (consisting of H2, CH4, N2, O2, and CO2) by means of fiber-enhanced Raman spectroscopy (FERS). An elaborate FERS setup with a microstructured hollow core photonic crystal fiber (HCPCF) provided a highly improved analytical sensitivity. The simultaneous monitoring of H2 with all other gases was achieved by a combination of rotational (H2) and vibrational (other gases) Raman spectroscopy within the limited spectral transmission range of the HCPCF. The HCPCF was combined with an adjustable image-plane aperture pinhole, in order to separate the H2 rotational Raman bands from the silica background signal and improve the sensitivity down to a limit of detection (LOD) of 4.7 ppm (for only 26 fmol H2). The ability to monitor the levels of H2 and CH4 in a positive hydrogen breath test (HBT) was demonstrated. The FERS sensor possesses a high dynamic range (∼5 orders of magnitude) with a fast response time of few seconds and provides great potential for miniaturization. We foresee that this technique will pave the way for fast, noninvasive, and painless point-of-care diagnosis of metabolic diseases in exhaled human breath.

  20. Rapid, sensitive, and specific lateral-flow immunochromatographic point-of-care device for detection of herpes simplex virus type 2-specific immunoglobulin G antibodies in serum and whole blood.

    Science.gov (United States)

    Laderman, Elisabeth I; Whitworth, Emma; Dumaual, Erickson; Jones, Mark; Hudak, Andrew; Hogrefe, Wayne; Carney, Jim; Groen, Jan

    2008-01-01

    Herpes simplex virus type 2 (HSV-2) is a common human pathogen that can cause a variety of clinical manifestations in humans. In order to provide near-patient results to allow for faster counseling and treatment, a rapid point-of-care test that is accurate and simple to use is desirable. Here, we describe the development and evaluation of an HSV-2 immunoglobulin G (IgG)-specific antibody lateral-flow immunochromatographic assay (LFIA) based on colloidal gold nanoparticles. A total of 359 serum samples and 100 whole-blood samples were tested in the newly developed HSV-2 LFIA. Serum results were compared to those from the HerpeSelect HSV-2 enzyme-linked immunosorbent assay (ELISA), and whole-blood sample results were compared to those of both ELISA and HerpeSelect HSV-1 and -2 immunoblotting (IB). The sensitivity of the HSV-2 LFIA compared to that of the HerpeSelect ELISA was 100% (89/89), and the specificity was 97.3% (257/264). Cross-reactivity with HSV-1 IgG-positive serum samples was observed in 2.6% (5/196) of samples, 2.9% (1/34) for rubella virus, and 6.2% (1/16) for Epstein-Barr virus. No cross-reactivity in varicella-zoster virus or cytomegalovirus IgG-positive serum samples was observed. No interference was observed from bilirubin-, triglyceride-, albumin-, or hemoglobin-spiked samples. The concordance of the LFIA results between capillary whole blood, EDTA-treated venous whole blood, heparin-treated venous whole blood, and serum was 99% (99/100). In conclusion, the LFIA for HSV-2 IgG-specific antibodies demonstrated excellent sensitivity, specificity, and concordance for both serum and whole-blood samples compared to the sensitivity, specificity, and concordance of both HSV-2 ELISA and IB.

  1. Rapid, Sensitive, and Specific Lateral-Flow Immunochromatographic Point-of-Care Device for Detection of Herpes Simplex Virus Type 2-Specific Immunoglobulin G Antibodies in Serum and Whole Blood▿

    Science.gov (United States)

    Laderman, Elisabeth I.; Whitworth, Emma; Dumaual, Erickson; Jones, Mark; Hudak, Andrew; Hogrefe, Wayne; Carney, Jim; Groen, Jan

    2008-01-01

    Herpes simplex virus type 2 (HSV-2) is a common human pathogen that can cause a variety of clinical manifestations in humans. In order to provide near-patient results to allow for faster counseling and treatment, a rapid point-of-care test that is accurate and simple to use is desirable. Here, we describe the development and evaluation of an HSV-2 immunoglobulin G (IgG)-specific antibody lateral-flow immunochromatographic assay (LFIA) based on colloidal gold nanoparticles. A total of 359 serum samples and 100 whole-blood samples were tested in the newly developed HSV-2 LFIA. Serum results were compared to those from the HerpeSelect HSV-2 enzyme-linked immunosorbent assay (ELISA), and whole-blood sample results were compared to those of both ELISA and HerpeSelect HSV-1 and -2 immunoblotting (IB). The sensitivity of the HSV-2 LFIA compared to that of the HerpeSelect ELISA was 100% (89/89), and the specificity was 97.3% (257/264). Cross-reactivity with HSV-1 IgG-positive serum samples was observed in 2.6% (5/196) of samples, 2.9% (1/34) for rubella virus, and 6.2% (1/16) for Epstein-Barr virus. No cross-reactivity in varicella-zoster virus or cytomegalovirus IgG-positive serum samples was observed. No interference was observed from bilirubin-, triglyceride-, albumin-, or hemoglobin-spiked samples. The concordance of the LFIA results between capillary whole blood, EDTA-treated venous whole blood, heparin-treated venous whole blood, and serum was 99% (99/100). In conclusion, the LFIA for HSV-2 IgG-specific antibodies demonstrated excellent sensitivity, specificity, and concordance for both serum and whole-blood samples compared to the sensitivity, specificity, and concordance of both HSV-2 ELISA and IB. PMID:18003814

  2. On conditions and parameters important to model sensitivity for unsaturated flow through layered, fractured tuff; Results of analyses for HYDROCOIN [Hydrologic Code Intercomparison Project] Level 3 Case 2: Yucca Mountain Project

    Energy Technology Data Exchange (ETDEWEB)

    Prindle, R.W.; Hopkins, P.L.

    1990-10-01

    The Hydrologic Code Intercomparison Project (HYDROCOIN) was formed to evaluate hydrogeologic models and computer codes and their use in performance assessment for high-level radioactive-waste repositories. This report describes the results of a study for HYDROCOIN of model sensitivity for isothermal, unsaturated flow through layered, fractured tuffs. We investigated both the types of flow behavior that dominate the performance measures and the conditions and model parameters that control flow behavior. We also examined the effect of different conceptual models and modeling approaches on our understanding of system behavior. The analyses included single- and multiple-parameter variations about base cases in one-dimensional steady and transient flow and in two-dimensional steady flow. The flow behavior is complex even for the highly simplified and constrained system modeled here. The response of the performance measures is both nonlinear and nonmonotonic. System behavior is dominated by abrupt transitions from matrix to fracture flow and by lateral diversion of flow. The observed behaviors are strongly influenced by the imposed boundary conditions and model constraints. Applied flux plays a critical role in determining the flow type but interacts strongly with the composite-conductivity curves of individual hydrologic units and with the stratigraphy. One-dimensional modeling yields conservative estimates of distributions of groundwater travel time only under very limited conditions. This study demonstrates that it is wrong to equate the shortest possible water-travel path with the fastest path from the repository to the water table. 20 refs., 234 figs., 10 tabs.

  3. Tipping Point

    Medline Plus

    Full Text Available ... Point by CPSC Blogger September 22, 2009 appliance child Childproofing CPSC danger death electrical fall furniture head ... see news reports about horrible accidents involving young children and furniture, appliance and tv tip-overs. The ...

  4. Hybrid Capture-Based Comprehensive Genomic Profiling Identifies Lung Cancer Patients with Well-Characterized Sensitizing Epidermal Growth Factor Receptor Point Mutations That Were Not Detected by Standard of Care Testing.

    Science.gov (United States)

    Suh, James H; Schrock, Alexa B; Johnson, Adrienne; Lipson, Doron; Gay, Laurie M; Ramkissoon, Shakti; Vergilio, Jo-Anne; Elvin, Julia A; Shakir, Abdur; Ruehlman, Peter; Reckamp, Karen L; Ou, Sai-Hong Ignatius; Ross, Jeffrey S; Stephens, Philip J; Miller, Vincent A; Ali, Siraj M

    2018-03-14

    In our recent study, of cases positive for epidermal growth factor receptor ( EGFR ) exon 19 deletions using comprehensive genomic profiling (CGP), 17/77 (22%) patients with prior standard of care (SOC) EGFR testing results available were previously negative for exon 19 deletion. Our aim was to compare the detection rates of CGP versus SOC testing for well-characterized sensitizing EGFR point mutations (pm) in our 6,832-patient cohort. DNA was extracted from 40 microns of formalin-fixed paraffin-embedded sections from 6,832 consecutive cases of non-small cell lung cancer (NSCLC) of various histologies (2012-2015). CGP was performed using a hybrid capture, adaptor ligation-based next-generation sequencing assay to a mean coverage depth of 576×. Genomic alterations (pm, small indels, copy number changes and rearrangements) involving EGFR were recorded for each case and compared with prior testing results if available. Overall, there were 482 instances of EGFR exon 21 L858R (359) and L861Q (20), exon 18 G719X (73) and exon 20 S768I (30) pm, of which 103 unique cases had prior EGFR testing results that were available for review. Of these 103 cases, CGP identified 22 patients (21%) with sensitizing EGFR pm that were not detected by SOC testing, including 9/75 (12%) patients with L858R, 4/7 (57%) patients with L861Q, 8/20 (40%) patients with G719X, and 4/7 (57%) patients with S768I pm (some patients had multiple EGFR pm). In cases with available clinical data, benefit from small molecule inhibitor therapy was observed. CGP, even when applied to low tumor purity clinical-grade specimens, can detect well-known EGFR pm in NSCLC patients that would otherwise not be detected by SOC testing. Taken together with EGFR exon 19 deletions, over 20% of patients who are positive for EGFR -activating mutations using CGP are previously negative by SOC EGFR mutation testing, suggesting that thousands of such patients per year in the U.S. alone could experience improved clinical

  5. Addition of docetaxel or bisphosphonates to standard of care in men with localised or metastatic, hormone-sensitive prostate cancer: a systematic review and meta-analyses of aggregate data.

    Science.gov (United States)

    Vale, Claire L; Burdett, Sarah; Rydzewska, Larysa H M; Albiges, Laurence; Clarke, Noel W; Fisher, David; Fizazi, Karim; Gravis, Gwenaelle; James, Nicholas D; Mason, Malcolm D; Parmar, Mahesh K B; Sweeney, Christopher J; Sydes, Matthew R; Tombal, Bertrand; Tierney, Jayne F

    2016-02-01

    benefit from the addition of zoledronic acid (0·94 [0·83-1·07]; p=0·323), which translates to an absolute improvement in survival of 2% (-3 to 7). Of 17 trials of bisphosphonates for men with M0 disease, survival results from four trials (4079 [66%] of 6220 men) showed no evidence of benefit from the addition of bisphosphonates (1·03 [0·89-1·18]; p=0·724) or zoledronic acid (0·98 [0·82-1·16]; p=0·782). Failure-free survival definitions were too inconsistent for formal meta-analyses for the bisphosphonate trials. The addition of docetaxel to standard of care should be considered standard care for men with M1 hormone-sensitive prostate cancer who are starting treatment for the first time. More evidence on the effects of docetaxel on survival is needed in the M0 disease setting. No evidence exists to suggest that zoledronic acid improves survival in men with M1 or M0 disease, and any potential benefit is probably small. Medical Research Council UK. Copyright © 2016 Vale et al. Open Access article distributed under the terms of CC-BY. Published by Elsevier Ltd.. All rights reserved.

  6. Sensitivity and uncertainty analysis

    CERN Document Server

    Cacuci, Dan G; Navon, Ionel Michael

    2005-01-01

    As computer-assisted modeling and analysis of physical processes have continued to grow and diversify, sensitivity and uncertainty analyses have become indispensable scientific tools. Sensitivity and Uncertainty Analysis. Volume I: Theory focused on the mathematical underpinnings of two important methods for such analyses: the Adjoint Sensitivity Analysis Procedure and the Global Adjoint Sensitivity Analysis Procedure. This volume concentrates on the practical aspects of performing these analyses for large-scale systems. The applications addressed include two-phase flow problems, a radiative c

  7. Analyse de Le web 2.0 en classe de langue – Une réflexion théorique et des activités pratiques pour faire le point

    Directory of Open Access Journals (Sweden)

    Maud Ciekanski

    2012-12-01

    Full Text Available 1. Délimitation de l'ouvrage L'ouvrage Le web 2.0 en classe de langue, co-écrit par Christian Ollivier et Laurent Puren, de l'université de La Réunion, tous deux experts dans la formation de formateurs et dans l'utilisation des TIC (technologies de l'information et de la communication en situation d'apprentissage des langues, se propose de faire le point sur ce que les auteurs nomment "le phénomène web 2.0" de façon à permettre aux enseignants de langues d'enrichir leurs pratiques en découvr...

  8. A new high-resolution small-angle X-ray scattering apparatus using a fine-focus rotating anode, point-focusing collimation and a position-sensitive proportional counter

    International Nuclear Information System (INIS)

    Yoda, O.

    1984-01-01

    A high-resolution small-angle X-ray scattering camera has been built, which has the following features. (i) The point collimation optics employed allows the scattering cross section of the sample to be directly measured without corrections for desmearing. (ii) A small-angle resolution better than 0.5 mrad is achieved with a camera length of 1.6 m. (iii) A high photon flux of 0.9 photons μs -1 is obtained on the sample with the rotating-anode X-ray generator operated at 40 kV-30 mA. (iv) Incident X-rays are monochromatized by a bent quartz crystal, which makes the determination of the incident X-ray intensity simple and unambiguous. (v) By rotation of the position-sensitive proportional counter around the direct beam, anisotropic scattering patterns can be observed without adjusting the sample. Details of the design and performance are presented with some applications. (Auth.)

  9. Maryland ESI: NESTS (Nest Points)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains sensitive biological resource data for raptors in Maryland. Vector points in this data set represent bird nesting sites. Species-specific...

  10. Virginia ESI: REPTPT (Reptile Points)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains sensitive biological resource data for sea turtles in Virginia. Vector points in this data set represent nesting sites. Species-specific...

  11. Louisiana ESI: NESTS (Nest Points)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains sensitive biological resource data for seabird and wading bird nesting colonies in coastal Louisiana. Vector points in this data set represent...

  12. Hawaii ESI: NESTS (Nest Points)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains sensitive biological resource data for seabird nesting colonies in coastal Hawaii. Vector points in this data set represent locations of...

  13. LHS (latin hypercubes) sampling of the material properties of steels for the analysis of the global sensitivity in welding numerical simulation; Echantillonnage LHS des proprietes materiau des aciers pour l analyse de sensibilite globale en simulation numerique du soudage

    Energy Technology Data Exchange (ETDEWEB)

    Petelet, Matthieu; Asserin, Olivier [CEA, DRT / LITEN / DTH / LTA, Bat 611, 91191 Gif sur Yvette Cedex (France); Iooss, Bertrand [CEA, DEN / CAD / DER / SESI / LCFR, Bat 212, 13108 St-Paul-lez-Durance Cedex (France); Petelet, Matthieu; Loredo, Alexandre [ISAT / LRMA, 49 rue Melle Bourgeois, BP 31, 58027 Nevers Cedex (France)

    2006-07-01

    In this work, the method of sensitivity analysis allowing to identify the inlet data the most influential on the variability of the responses (residual stresses and distortions). Classically, the sensitivity analysis is carried out locally what limits its validity domain to a given material. A global sensitivity analysis method is proposed; it allows to cover a material domain as wide as those of the steels series. A probabilistic modeling giving the variability of the material parameters in the steels series is proposed. The original aspect of this work consists in the use of the sampling method by latin hypercubes (LHS) of the material parameters which forms the inlet data (dependent of temperature) of the numerical simulations. Thus, a statistical approach has been applied to the welding numerical simulation: LHS sampling of the material properties, global sensitivity analysis what has allowed the reduction of the material parameterization. (O.M.)

  14. In situ sulfur isotopes (δ{sup 34}S and δ{sup 33}S) analyses in sulfides and elemental sulfur using high sensitivity cones combined with the addition of nitrogen by laser ablation MC-ICP-MS

    Energy Technology Data Exchange (ETDEWEB)

    Fu, Jiali [State Key Laboratory of Geological Processes and Mineral Resources, China University of Geosciences, Wuhan 430074 (China); Hu, Zhaochu, E-mail: zchu@vip.sina.com [State Key Laboratory of Geological Processes and Mineral Resources, China University of Geosciences, Wuhan 430074 (China); The Beijing SHRIMP Center, Institute of Geology, Chinese Academy of Geological Sciences, Beijing 102206 (China); Zhang, Wen [State Key Laboratory of Geological Processes and Mineral Resources, China University of Geosciences, Wuhan 430074 (China); Yang, Lu [State Key Laboratory of Geological Processes and Mineral Resources, China University of Geosciences, Wuhan 430074 (China); National Research Council Canada, 1200 Montreal Rd., Ottawa, Ontario K1A 0R6 (Canada); Liu, Yongsheng; Li, Ming; Zong, Keqing; Gao, Shan; Hu, Shenghong [State Key Laboratory of Geological Processes and Mineral Resources, China University of Geosciences, Wuhan 430074 (China)

    2016-03-10

    The sulfur isotope is an important geochemical tracer in diverse fields of geosciences. In this study, the effects of three different cone combinations with the addition of N{sub 2} on the performance of in situ S isotope analyses were investigated in detail. The signal intensities of S isotopes were improved by a factor of 2.3 and 3.6 using the X skimmer cone combined with the standard sample cone or the Jet sample cone, respectively, compared with the standard arrangement (H skimmer cone combined with the standard sample cone). This signal enhancement is important for the improvement of the precision and accuracy of in situ S isotope analysis at high spatial resolution. Different cone combinations have a significant effect on the mass bias and mass bias stability for S isotopes. Poor precisions of S isotope ratios were obtained using the Jet and X cones combination at their corresponding optimum makeup gas flow when using Ar plasma only. The addition of 4–8 ml min{sup −1} nitrogen to the central gas flow in laser ablation MC-ICP-MS was found to significantly enlarge the mass bias stability zone at their corresponding optimum makeup gas flow in these three different cone combinations. The polyatomic interferences of OO, SH, OOH were also significantly reduced, and the interference free plateaus of sulfur isotopes became broader and flatter in the nitrogen mode (N{sub 2} = 4 ml min{sup −1}). However, the signal intensity of S was not increased by the addition of nitrogen in this study. The laser fluence and ablation mode had significant effects on sulfur isotope fractionation during the analysis of sulfides and elemental sulfur by laser ablation MC-ICP-MS. The matrix effect among different sulfides and elemental sulfur was observed, but could be significantly reduced by line scan ablation in preference to single spot ablation under the optimized fluence. It is recommended that the d{sub 90} values of the particles in pressed powder pellets for accurate

  15. In situ sulfur isotopes (δ34S and δ33S) analyses in sulfides and elemental sulfur using high sensitivity cones combined with the addition of nitrogen by laser ablation MC-ICP-MS

    International Nuclear Information System (INIS)

    Fu, Jiali; Hu, Zhaochu; Zhang, Wen; Yang, Lu; Liu, Yongsheng; Li, Ming; Zong, Keqing; Gao, Shan; Hu, Shenghong

    2016-01-01

    The sulfur isotope is an important geochemical tracer in diverse fields of geosciences. In this study, the effects of three different cone combinations with the addition of N 2 on the performance of in situ S isotope analyses were investigated in detail. The signal intensities of S isotopes were improved by a factor of 2.3 and 3.6 using the X skimmer cone combined with the standard sample cone or the Jet sample cone, respectively, compared with the standard arrangement (H skimmer cone combined with the standard sample cone). This signal enhancement is important for the improvement of the precision and accuracy of in situ S isotope analysis at high spatial resolution. Different cone combinations have a significant effect on the mass bias and mass bias stability for S isotopes. Poor precisions of S isotope ratios were obtained using the Jet and X cones combination at their corresponding optimum makeup gas flow when using Ar plasma only. The addition of 4–8 ml min −1 nitrogen to the central gas flow in laser ablation MC-ICP-MS was found to significantly enlarge the mass bias stability zone at their corresponding optimum makeup gas flow in these three different cone combinations. The polyatomic interferences of OO, SH, OOH were also significantly reduced, and the interference free plateaus of sulfur isotopes became broader and flatter in the nitrogen mode (N 2  = 4 ml min −1 ). However, the signal intensity of S was not increased by the addition of nitrogen in this study. The laser fluence and ablation mode had significant effects on sulfur isotope fractionation during the analysis of sulfides and elemental sulfur by laser ablation MC-ICP-MS. The matrix effect among different sulfides and elemental sulfur was observed, but could be significantly reduced by line scan ablation in preference to single spot ablation under the optimized fluence. It is recommended that the d 90 values of the particles in pressed powder pellets for accurate and precise S isotope

  16. Fertility chip, a point-of-care semen analyser

    NARCIS (Netherlands)

    Segerink, Loes Irene

    2011-01-01

    Before assistive reproductive treatment will be started for a couple that is childless by default, the cause of the fertility disorder needs to be investigated for both the man as well as the woman. For the man this implies that the quality of his semen needs to be known. Currently, at the hospital

  17. Common variants in the ATP-sensitive K channel genes KCNJ11 (Kir6.2) and ABCC8 (SUR1) in relation to glucose intolerance: population-based studies and meta-analyses

    NARCIS (Netherlands)

    Dam, van R.M.; Hoebee, B.; Seidell, J.C.; Schaap, M.M.; Bruin, de T.W.; Feskens, E.J.M.

    2005-01-01

    Abstract Aims To evaluate the relation between common variants in the ATP-sensitive K(+) channel genes and glucose intolerance. Methods We conducted a meta-analysis of reported association studies in Caucasian populations for common variants in the ABCC8 (exons 16 and 18) and the KCNJ11 (E23K) gene

  18. Analyse de la sensibilité aux paramètres gazoles d'un moteur diesel d'automobile à injection directe Small Direct Injection Diesel Engine Sensitivity to the Diesel Fuel Characteristics

    Directory of Open Access Journals (Sweden)

    Montagne X.

    2006-12-01

    particules totales sont plutôt dépendantes de la viscosité et des fractions légères des carburants. Les émissions sonores sont étroitement liées à l'indice de cétane. Par ailleurs, l'ensemble des résultats acquis semble indiquer que les paramètres pilotant le délai d'auto-inflammation sont importants sur ce type de convertisseur. Il serait cependant nécessaire de disposer de mesures directes des caractéristiques des jets d'injection (taille des gouttelettes, pénétration du spray en fonction des différents carburants pour pouvoir quantifier l'effet des paramètres tels que la viscosité et la densité sur la partie physique du délai d'auto-inflammation. Among the technical solutions that can lead to energy converters with low pollutant emissions and low fuel consumption, diesel engines rank, by nature, in a good position. On this base, direct injection diesel engine has been developed and are now spreading in private passanger cars because of their performances, especially in terms of fuel consumption. However, this equipment requires an efficient injection system, electronically driven, needs EGR and an oxidation catalyst to improve the pollutant emissions and the noise level. Thus, it is a major concern to be able to assess precisely the sensitivity to fuel characteristics of direct injection engines as to take the best advantage of this technology. With a set of fuels formulated to cover a large range of chemical nature, viscosity, cetane number and density, an Audi direct injection engine (1Z model was run at the test bench. The impact of the fuel characteristics on pollutant emissions, regulated or unregulated (PAH, aldehydes, and on noise levels was assessed either under standard tuning conditions, either by changing the EGR rate and the injection timing. The results obtained at the end of this program point out the main criteria that have an influence on emissions. They also allow a comparison between direct injection engines and their homologues

  19. Latent myofascial trigger points.

    Science.gov (United States)

    Ge, Hong-You; Arendt-Nielsen, Lars

    2011-10-01

    A latent myofascial trigger point (MTP) is defined as a focus of hyperirritability in a muscle taut band that is clinically associated with local twitch response and tenderness and/or referred pain upon manual examination. Current evidence suggests that the temporal profile of the spontaneous electrical activity at an MTP is similar to focal muscle fiber contraction and/or muscle cramp potentials, which contribute significantly to the induction of local tenderness and pain and motor dysfunctions. This review highlights the potential mechanisms underlying the sensory-motor dysfunctions associated with latent MTPs and discusses the contribution of central sensitization associated with latent MTPs and the MTP network to the spatial propagation of pain and motor dysfunctions. Treating latent MTPs in patients with musculoskeletal pain may not only decrease pain sensitivity and improve motor functions, but also prevent latent MTPs from transforming into active MTPs, and hence, prevent the development of myofascial pain syndrome.

  20. Reliability Analyses of Groundwater Pollutant Transport

    Energy Technology Data Exchange (ETDEWEB)

    Dimakis, Panagiotis

    1997-12-31

    This thesis develops a probabilistic finite element model for the analysis of groundwater pollution problems. Two computer codes were developed, (1) one using finite element technique to solve the two-dimensional steady state equations of groundwater flow and pollution transport, and (2) a first order reliability method code that can do a probabilistic analysis of any given analytical or numerical equation. The two codes were connected into one model, PAGAP (Probability Analysis of Groundwater And Pollution). PAGAP can be used to obtain (1) the probability that the concentration at a given point at a given time will exceed a specified value, (2) the probability that the maximum concentration at a given point will exceed a specified value and (3) the probability that the residence time at a given point will exceed a specified period. PAGAP could be used as a tool for assessment purposes and risk analyses, for instance the assessment of the efficiency of a proposed remediation technique or to study the effects of parameter distribution for a given problem (sensitivity study). The model has been applied to study the greatest self sustained, precipitation controlled aquifer in North Europe, which underlies Oslo`s new major airport. 92 refs., 187 figs., 26 tabs.

  1. ACS Zero Point Verification

    Science.gov (United States)

    Dolphin, Andrew

    2005-07-01

    The uncertainties in the photometric zero points create a fundamental limit to the accuracy of photometry. The current state of the ACS calibration is surprisingly poor, with zero point uncertainties of 0.03 magnitudes. The reason for this is that the ACS calibrations are based primarily on semi-emprical synthetic zero points and observations of fields too crowded for accurate ground-based photometry. I propose to remedy this problem by obtaining ACS images of the omega Cen standard field with all nine broadband ACS/WFC filters. This will permit the direct determination of the ACS zero points by comparison with excellent ground-based photometry, and should reduce their uncertainties to less than 0.01 magnitudes. A second benefit is that it will facilitate the comparison of the WFPC2 and ACS photometric systems, which will be important as WFPC2 is phased out and ACS becomes HST's primary imager. Finally, three of the filters will be repeated from my Cycle 12 observations, allowing for a measurement of any change in sensitivity.

  2. Stress and odor sensitivity in persons with noise sensitivity.

    Science.gov (United States)

    Nordin, Steven; Ljungberg, Jessica Korning; Claeson, Anna-Sara; Neely, Gregory

    2013-01-01

    Previous research has indicated that sensory sensitivity/intolerance to a specific modality may be part of a more general environmental hypersensitivity, and possibly mediated by stress. This study investigated the relationship between noise sensitivity, perceived stress, and odor sensitivity in a group of men. A quasi-experimental design was used. One-hundred and thirty-four male undergraduate students completed Weinstein's noise sensitivity scale from which a low-sensitivity group (n = 16) and a high-sensitivity (n = 16) group were formed. These two groups were screened for loss in auditory and olfactory detection sensitivity, and completed the perceived stress questionnaire (PSQ) and the chemical sensitivity scale (CSS). One-way analysis of variance and Spearman correlational analyses were performed. Significantly higher scores on the PSQ (P noise-sensitivity group compared to the low noise-sensitivity group. These findings raise the question of whether the relation between noise and odor sensitivity reflects a general environmental sensitivity.

  3. Clinical sensitivity and specificity of the Check-Points Check-Direct ESBL Screen for BD MAX, a real-time PCR for direct ESBL detection from rectal swabs

    NARCIS (Netherlands)

    Souverein, Dennis; Euser, Sjoerd M.; Reijden, Wil A. van der; Herpers, Bjorn L.; Kluytmans, Jan; Rossen, John W A; Den Boer, Jeroen W.

    Objectives: To determine the diagnostic accuracy of the Check-Direct ESBL Screen for BD MAX (ESBL qPCR) and an ESBL culture method to identify ESBLs directly from rectal swabs. Methods: Rectal swabs were obtained from clinical patients by performing cross-sectional (point) prevalence measurements in

  4. Development, Testing, and Sensitivity and Uncertainty Analyses of a Transport and Reaction Simulation Engine (TaRSE) for Spatially Distributed Modeling of Phosphorus in South Florida Peat Marsh Wetlands

    Science.gov (United States)

    Jawitz, James W.; Munoz-Carpena, Rafael; Muller, Stuart; Grace, Kevin A.; James, Andrew I.

    2008-01-01

    in the phosphorus cycling mechanisms were simulated in these case studies using different combinations of phosphorus reaction equations. Changes in water column phosphorus concentrations observed under the controlled conditions of laboratory incubations, and mesocosm studies were reproduced with model simulations. Short-term phosphorus flux rates and changes in phosphorus storages were within the range of values reported in the literature, whereas unknown rate constants were used to calibrate the model output. In STA-1W Cell 4, the dominant mechanism for phosphorus flow and transport is overland flow. Over many life cycles of the biological components, however, soils accrue and become enriched in phosphorus. Inflow total phosphorus concentrations and flow rates for the period between 1995 and 2000 were used to simulate Cell 4 phosphorus removal, outflow concentrations, and soil phosphorus enrichment over time. This full-scale application of the model successfully incorporated parameter values derived from the literature and short-term experiments, and reproduced the observed long-term outflow phosphorus concentrations and increased soil phosphorus storage within the system. A global sensitivity and uncertainty analysis of the model was performed using modern techniques such as a qualitative screening tool (Morris method) and the quantitative, variance-based, Fourier Amplitude Sensitivity Test (FAST) method. These techniques allowed an in-depth exploration of the effect of model complexity and flow velocity on model outputs. Three increasingly complex levels of possible application to southern Florida were studied corresponding to a simple soil pore-water and surface-water system (level 1), the addition of plankton (level 2), and of macrophytes (level 3). In the analysis for each complexity level, three surface-water velocities were considered that each correspond to residence times for the selected area (1-kilometer long) of 2, 10, and 20

  5. Severe Accident Recriticality Analyses (SARA)

    Energy Technology Data Exchange (ETDEWEB)

    Frid, W. [Swedish Nuclear Power Inspectorate, Stockholm (Sweden); Hoejerup, F. [Risoe National Lab. (Denmark); Lindholm, I.; Miettinen, J.; Puska, E.K. [VTT Energy, Helsinki (Finland); Nilsson, Lars [Studsvik Eco and Safety AB, Nykoeping (Sweden); Sjoevall, H. [Teoliisuuden Voima Oy (Finland)

    1999-11-01

    rate of 2000 kg/s. In most cases, however, the predicted energy deposition was much smaller, below the regulatory limits for fuel failure, but close or above recently observed thresholds for fragmentation and dispersion of high burn-up fuel. The highest calculated quasi steady-state power following initial power excursion was in most cases about 20 % of the nominal reactor power, according to SIMULATE-3K and APROS. RECRIT predictions were in general different in this respect with either oscillating power or power increase approaching 50 % of nominal power which in both cases resulted in fuel temperatures above the melting point as a result of insufficient cooling. Long-term containment response to recriticality was assessed through MELCOR calculations for Olkiluoto 1 plant. At stabilised reactor power of 19 % of nominal power the containment failure due to overpressurization was predicted to occur 1.3 h after recriticality, if the accident is not mitigated. The SARA studies have clearly shown the sensitivity of recriticality phenomena to thermal-hydraulic modelling, the specifics of accident scenario, such as distribution of boron-carbide, and importance of multi-dimensional kinetics for determination of local power distribution in the core. The results of the project have pointed out the importance of adequate accident management procedures to be used by reactor operators and emergency staff during recovery actions. Recommendations in this area are given in the report.

  6. Network class superposition analyses.

    Directory of Open Access Journals (Sweden)

    Carl A B Pearson

    Full Text Available Networks are often used to understand a whole system by modeling the interactions among its pieces. Examples include biomolecules in a cell interacting to provide some primary function, or species in an environment forming a stable community. However, these interactions are often unknown; instead, the pieces' dynamic states are known, and network structure must be inferred. Because observed function may be explained by many different networks (e.g., ≈ 10(30 for the yeast cell cycle process, considering dynamics beyond this primary function means picking a single network or suitable sample: measuring over all networks exhibiting the primary function is computationally infeasible. We circumvent that obstacle by calculating the network class ensemble. We represent the ensemble by a stochastic matrix T, which is a transition-by-transition superposition of the system dynamics for each member of the class. We present concrete results for T derived from boolean time series dynamics on networks obeying the Strong Inhibition rule, by applying T to several traditional questions about network dynamics. We show that the distribution of the number of point attractors can be accurately estimated with T. We show how to generate Derrida plots based on T. We show that T-based Shannon entropy outperforms other methods at selecting experiments to further narrow the network structure. We also outline an experimental test of predictions based on T. We motivate all of these results in terms of a popular molecular biology boolean network model for the yeast cell cycle, but the methods and analyses we introduce are general. We conclude with open questions for T, for example, application to other models, computational considerations when scaling up to larger systems, and other potential analyses.

  7. Sensitivity analysis

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/article/003741.htm Sensitivity analysis To use the sharing features on this page, please enable JavaScript. Sensitivity analysis determines the effectiveness of antibiotics against microorganisms (germs) ...

  8. Address Points - Allegheny County Address Points 201601

    Data.gov (United States)

    NSGIC Education | GIS Inventory — This dataset contains Address Points in Allegheny County. The Address Points were created by GDR for the Allegheny County CAD project, October 2008. Data is updated...

  9. Sensitivity to volcanic field boundary

    Science.gov (United States)

    Runge, Melody; Bebbington, Mark; Cronin, Shane; Lindsay, Jan; Rashad Moufti, Mohammed

    2016-04-01

    Volcanic hazard analyses are desirable where there is potential for future volcanic activity to affect a proximal population. This is frequently the case for volcanic fields (regions of distributed volcanism) where low eruption rates, fertile soil, and attractive landscapes draw populations to live close by. Forecasting future activity in volcanic fields almost invariably uses spatial or spatio-temporal point processes with model selection and development based on exploratory analyses of previous eruption data. For identifiability reasons, spatio-temporal processes, and practically also spatial processes, the definition of a spatial region is required to which volcanism is confined. However, due to the complex and predominantly unknown sub-surface processes driving volcanic eruptions, definition of a region based solely on geological information is currently impossible. Thus, the current approach is to fit a shape to the known previous eruption sites. The class of boundary shape is an unavoidable subjective decision taken by the forecaster that is often overlooked during subsequent analysis of results. This study shows the substantial effect that this choice may have on even the simplest exploratory methods for hazard forecasting, illustrated using four commonly used exploratory statistical methods and two very different regions: the Auckland Volcanic Field, New Zealand, and Harrat Rahat, Kingdom of Saudi Arabia. For Harrat Rahat, sensitivity of results to boundary definition is substantial. For the Auckland Volcanic Field, the range of options resulted in similar shapes, nevertheless, some of the statistical tests still showed substantial variation in results. This work highlights the fact that when carrying out any hazard analysis on volcanic fields, it is vital to specify how the volcanic field boundary has been defined, assess the sensitivity of boundary choice, and to carry these assumptions and related uncertainties through to estimates of future activity and

  10. A TOUCH-SENSITIVE DEVICE

    DEFF Research Database (Denmark)

    2009-01-01

    The present invention relates to an optical touch-sensitive device and a method of determining a position and determining a position change of an object contacting an optical touch sensitive device. In particular, the present invention relates to an optical touch pad and a method of determining...... a position and determining a position change of an object contacting an optical touch pad. A touch-sensitive device, according to the present invention may comprise a light source, a touch- sensitive waveguide, a detector array, and a first light redirecting member, wherein at least a part of the light...... propagating towards a specific point of the detector array is prevented from being incident upon the specific point of the detector array when an object contacts a touch-sensitive surface of the touch-sensitive waveguide at a corresponding specific contact point....

  11. The Temporal Tipping Point

    DEFF Research Database (Denmark)

    Hermann, A. K.

    2016-01-01

    “Slow journalism” is a term anthropologist and sociologists sometimes use to describe their empirical work, ethnography. To journalists and media observers, meanwhile, “slow journalism” signifies a newfound dedication to serious long-form journalism. Not surprisingly, thus, “ethnographic journalism......”—a genre where reporters adopt research strategies from social science—takes “slow” to the extreme. Immersing themselves in communities for weeks, months and years, ethnographic journalists seek to gain what anthropologists call “the native's point of view”. Based on in-depth interviews with practitioners...... and analyses of their journalistic works, this paper offers a study of ethnographic journalism suggesting that slow time operates in at least three separate registers. First, in terms of regimentation, ethnographic journalism is mostly long-form pieces that demand time-consuming research and careful writing...

  12. Low-energy point source searches with IceCube

    Directory of Open Access Journals (Sweden)

    Euler Sebastian

    2016-01-01

    Full Text Available Due to the overwhelming background of atmospheric muons, the traditional IceCube point source search in the Southern Hemisphere is mainly sensitive to neutrinos with energies above 100TeV. A new approach focuses on events starting inside the instrumented volume. By utilizing different veto techniques we are able to significantly reduce the energy threshold and can now for the first time explore the entire Southern Hemisphere at neutrino energies as low as 100GeV. We present the results of two analyses targeting slightly different energy ranges. Both use one year of data taken with the completed IceCube detector in 2011/12.

  13. Beyond sensitivity analysis

    DEFF Research Database (Denmark)

    Lund, Henrik; Sorknæs, Peter; Mathiesen, Brian Vad

    2018-01-01

    point of view, the typical way of handling this challenge has been to predict future prices as accurately as possible and then conduct a sensitivity analysis. This paper includes a historical analysis of such predictions, leading to the conclusion that they are almost always wrong. Not only...

  14. Development of a simple, sensitive and inexpensive ion-pairing cloud point extraction approach for the determination of trace inorganic arsenic species in spring water, beverage and rice samples by UV-Vis spectrophotometry.

    Science.gov (United States)

    Gürkan, Ramazan; Kır, Ufuk; Altunay, Nail

    2015-08-01

    The determination of inorganic arsenic species in water, beverages and foods become crucial in recent years, because arsenic species are considered carcinogenic and found at high concentrations in the samples. This communication describes a new cloud-point extraction (CPE) method for the determination of low quantity of arsenic species in the samples, purchased from the local market by UV-Visible Spectrophotometer (UV-Vis). The method is based on selective ternary complex of As(V) with acridine orange (AOH(+)) being a versatile fluorescence cationic dye in presence of tartaric acid and polyethylene glycol tert-octylphenyl ether (Triton X-114) at pH 5.0. Under the optimized conditions, a preconcentration factor of 65 and detection limit (3S blank/m) of 1.14 μg L(-1) was obtained from the calibration curve constructed in the range of 4-450 μg L(-1) with a correlation coefficient of 0.9932 for As(V). The method is validated by the analysis of certified reference materials (CRMs). Copyright © 2015 Elsevier Ltd. All rights reserved.

  15. Hawaii ESI: HABPT (Habitat and Plant Points)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains sensitive biological resource data for rare/native terrestrial plants in coastal Hawaii. Vector points in this data set represent rare/native...

  16. Columbia River ESI: NESTS (Nest Points)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains sensitive biological resource data for bird nesting sites in the Columbia River area. Vector points in this data set represent locations of...

  17. Parametric Sensitivity Analysis of Oscillatory Delay Systems with an Application to Gene Regulation.

    Science.gov (United States)

    Ingalls, Brian; Mincheva, Maya; Roussel, Marc R

    2017-07-01

    A parametric sensitivity analysis for periodic solutions of delay-differential equations is developed. Because phase shifts cause the sensitivity coefficients of a periodic orbit to diverge, we focus on sensitivities of the extrema, from which amplitude sensitivities are computed, and of the period. Delay-differential equations are often used to model gene expression networks. In these models, the parametric sensitivities of a particular genotype define the local geometry of the evolutionary landscape. Thus, sensitivities can be used to investigate directions of gradual evolutionary change. An oscillatory protein synthesis model whose properties are modulated by RNA interference is used as an example. This model consists of a set of coupled delay-differential equations involving three delays. Sensitivity analyses are carried out at several operating points. Comments on the evolutionary implications of the results are offered.

  18. Biochemical testing in a laboratory tent and semi-intensive care of Ebola patients on-site in a remote part of Guinea: a paradigm shift based on a bleach-sensitive point-of-care device.

    Science.gov (United States)

    Irenge, Leonid M; Dindart, Jean-Michel; Gala, Jean-Luc

    2017-10-26

    During the West Africa Ebola virus disease (EVD) outbreak, a Belgian laboratory was deployed for supporting the Ebola treatment unit (ETU) of N'Zerekore, Guinea. Besides diagnosis of EVD and malaria, biochemical parameters were tested and used to guide supportive treatment of EVD. To preserve analytes stability, lithium-heparin blood samples were analyzed using the i-STAT® point-of-care testing (POCT) handheld device without the viral inactivation step. To mitigate the risk of Ebola virus transmission, assays were performed inside a portable glovebox with strict biosafety procedures. Providing the medical staff with real-time biochemical data modified their therapeutic attitude, shifting from empiric to a semi-intensive laboratory-guided treatment of hydro-electrolytic disturbances, metabolic acidosis and/or impaired kidney function. As illustrated with representative EVD cases (n=8), optimized supportive treatment with intravenous fluid therapy and electrolyte replacement often helped correct these abnormalities. However, the harsh operating conditions, especially the use of bleach decontamination inside the glovebox, caused several technical failures and the final breakdown of the POCT device. POCT availability resulted in a paradigm shift in laboratory practice and care delivery at the N'Zerekore ETU. We conclude that there is urgent need for novel well-designed and validated POCT devices usable by non-expert operators in high ambient temperature and limited space. These devices should withstand regular and thorough decontamination by the personnel working on-site with life-threatening pathogens and be compatible with high biosafety level procedures. Such specific users' requirements need a European validation and standardization process of proposed solutions led by the EU Standardization Committee (CEN).

  19. Allergic sensitization

    DEFF Research Database (Denmark)

    van Ree, Ronald; Hummelshøj, Lone; Plantinga, Maud

    2014-01-01

    Allergic sensitization is the outcome of a complex interplay between the allergen and the host in a given environmental context. The first barrier encountered by an allergen on its way to sensitization is the mucosal epithelial layer. Allergic inflammatory diseases are accompanied by increased pe...

  20. Analyses for designing objects in mechanical design

    International Nuclear Information System (INIS)

    Nakajima, Norihiro; Miyamura, Hiroko N.; Kawakami, Yoshiaki; Kawamura, Takuma

    2015-01-01

    Defining factors to induce the damage that can be assumed in the mechanical structures, it is a loaded work to analyze a damage possibility point derived by the assumption phenomenon that can occur is, but it is the important designing process. Taking factors caused by the earthquake as an example, and simulating the phenomenon that can be assumed, the computational result was analyzed with information visualization. A damage possibility point by analyzing the result mathematically. The illustration of analytical results may give points to designers as means for a designer to recognize a damage possibility point from the sensitivity of the designer. (author)

  1. Constrained sensitivity theory

    International Nuclear Information System (INIS)

    Greenspan, E.; Williams, M.L.

    1980-01-01

    In sensitivity and uncertainty analysis of to-be-built reactors it is customary to use k-reset sensitivity functions - accounting for the combined effects of the change (or uncertainty) in the input data and of the alteration in some design variable applied to maintain criticality. Critical reactors are usually subjected to several constraints, such as power peaking factor and breeding ratio constraints, in addition to the criticality constraint. Perturbation theory formulations which can account, simultaneously, for several constraints both in critical reactors and in source driven systems (such as radiation shields and blankets of fusion devices) are presented. All the sensitivity and uncertainty analyses of source driven systems carried out so far used unconstrained sensitivity functions despite the fact that such systems can be also subjected to a variety of constraints

  2. Gluten Sensitivity

    Science.gov (United States)

    Gluten is a protein found in wheat, rye, and barley. It is found mainly in foods but ... products like medicines, vitamins, and supplements. People with gluten sensitivity have problems with gluten. It is different ...

  3. Radioecological sensitivity

    International Nuclear Information System (INIS)

    Howard, Brenda J.; Strand, Per; Assimakopoulos, Panayotis

    2003-01-01

    After the release of radionuclide into the environment it is important to be able to readily identify major routes of radiation exposure, the most highly exposed individuals or populations and the geographical areas of most concern. Radioecological sensitivity can be broadly defined as the extent to which an ecosystem contributes to an enhanced radiation exposure to Man and biota. Radioecological sensitivity analysis integrates current knowledge on pathways, spatially attributes the underlying processes determining transfer and thereby identifies the most radioecologically sensitive areas leading to high radiation exposure. This identifies where high exposure may occur and why. A framework for the estimation of radioecological sensitivity with respect to humans is proposed and the various indicators by which it can be considered have been identified. These are (1) aggregated transfer coefficients (Tag), (2) action (and critical) loads, (3) fluxes and (4) individual exposure of humans. The importance of spatial and temporal consideration of all these outputs is emphasized. Information on the extent of radionuclide transfer and exposure to humans at different spatial scales is needed to reflect the spatial differences which can occur. Single values for large areas, such as countries, can often mask large variation within the country. Similarly, the relative importance of different pathways can change with time and therefore assessments of radiological sensitivity are needed over different time periods after contamination. Radioecological sensitivity analysis can be used in radiation protection, nuclear safety and emergency preparedness when there is a need to identify areas that have the potential of being of particular concern from a risk perspective. Prior identification of radioecologically sensitive areas and exposed individuals improve the focus of emergency preparedness and planning, and contribute to environmental impact assessment for future facilities. The

  4. Analysing and Comparing Encodability Criteria

    Directory of Open Access Journals (Sweden)

    Kirstin Peters

    2015-08-01

    Full Text Available Encodings or the proof of their absence are the main way to compare process calculi. To analyse the quality of encodings and to rule out trivial or meaningless encodings, they are augmented with quality criteria. There exists a bunch of different criteria and different variants of criteria in order to reason in different settings. This leads to incomparable results. Moreover it is not always clear whether the criteria used to obtain a result in a particular setting do indeed fit to this setting. We show how to formally reason about and compare encodability criteria by mapping them on requirements on a relation between source and target terms that is induced by the encoding function. In particular we analyse the common criteria full abstraction, operational correspondence, divergence reflection, success sensitiveness, and respect of barbs; e.g. we analyse the exact nature of the simulation relation (coupled simulation versus bisimulation that is induced by different variants of operational correspondence. This way we reduce the problem of analysing or comparing encodability criteria to the better understood problem of comparing relations on processes.

  5. Myofascial trigger point pain.

    Science.gov (United States)

    Jaeger, Bernadette

    2013-01-01

    Myofascial trigger point pain is an extremely prevalent cause of persistent pain disorders in all parts of the body, not just the head, neck, and face. Features include deep aching pain in any structure, referred from focally tender points in taut bands of skeletal muscle (the trigger points). Diagnosis depends on accurate palpation with 2-4 kg/cm2 of pressure for 10 to 20 seconds over the suspected trigger point to allow the referred pain pattern to develop. In the head and neck region, cervical muscle trigger points (key trigger points) often incite and perpetuate trigger points (satellite trigger points) and referred pain from masticatory muscles. Management requires identification and control of as many perpetuating factors as possible (posture, body mechanics, psychological stress or depression, poor sleep or nutrition). Trigger point therapies such as spray and stretch or trigger point injections are best used as adjunctive therapy.

  6. Induction of formaldehyde contact sensitivity

    DEFF Research Database (Denmark)

    Andersen, Klaus Ejner; Boman, A; Vølund, A

    1985-01-01

    , and formaldehyde 1% and 0.1% was used for challenge. The incidence of contact sensitivity depended on the intradermal, but not on the topical induction dose. Statistical analyses showed a non-monotonous (non-linear) dose response relationship. The estimated maximal sensitization rate in Copenhagen was 80% after...

  7. Kamusal Karar Alma Süreçlerinde Sosyal Tercih Duyarlılığı ve Sürece İlişkin Yapısal Çözümlemeler(The Sensitivity of Social Preferences in Public Decisions Making Process and The Structural Analyses Connected with The Process

    Directory of Open Access Journals (Sweden)

    A. Niyazi ÖZKER

    2014-06-01

    Full Text Available In the study, we aim to bring up the social preferences location that have an important influence on the components of process consisting of social-economics together with the dynamics which should be considered by decision makers as the balanced component between the central government characteristics and the social preferences in public decision making process. Also, the dynamics’ negative effects as under approaches management of central governments’ politic strategies on the socially choices by taking shape publically point of view have been aimed to analyze connected with participation process. Hence, it is appear that the decisions’phenomenon directed towards to analyzes appear in very important the structural models in order to ensure the desired reality participation in decision making and also, the provided participation sensitive that lay the gramework for overtaking some paradox related to decision making process must be required to take into consideration and and check over as the primary point especially in the countries that have the structural politics matters.

  8. Global optimization and sensitivity analysis

    International Nuclear Information System (INIS)

    Cacuci, D.G.

    1990-01-01

    A new direction for the analysis of nonlinear models of nuclear systems is suggested to overcome fundamental limitations of sensitivity analysis and optimization methods currently prevalent in nuclear engineering usage. This direction is toward a global analysis of the behavior of the respective system as its design parameters are allowed to vary over their respective design ranges. Presented is a methodology for global analysis that unifies and extends the current scopes of sensitivity analysis and optimization by identifying all the critical points (maxima, minima) and solution bifurcation points together with corresponding sensitivities at any design point of interest. The potential applicability of this methodology is illustrated with test problems involving multiple critical points and bifurcations and comprising both equality and inequality constraints

  9. Impedance analysis of acupuncture points and pathways

    International Nuclear Information System (INIS)

    Teplan, Michal; Kukucka, Marek; Ondrejkovicová, Alena

    2011-01-01

    Investigation of impedance characteristics of acupuncture points from acoustic to radio frequency range is addressed. Discernment and localization of acupuncture points in initial single subject study was unsuccessfully attempted by impedance map technique. Vector impedance analyses determined possible resonant zones in MHz region.

  10. Impedance analysis of acupuncture points and pathways

    Science.gov (United States)

    Teplan, Michal; Kukučka, Marek; Ondrejkovičová, Alena

    2011-12-01

    Investigation of impedance characteristics of acupuncture points from acoustic to radio frequency range is addressed. Discernment and localization of acupuncture points in initial single subject study was unsuccessfully attempted by impedance map technique. Vector impedance analyses determined possible resonant zones in MHz region.

  11. The End of Points

    Science.gov (United States)

    Feldman, Jo

    2018-01-01

    Have teachers become too dependent on points? This article explores educators' dependency on their points systems, and the ways that points can distract teachers from really analyzing students' capabilities and achievements. Feldman argues that using a more subjective grading system can help illuminate crucial information about students and what…

  12. Sensing with Superconducting Point Contacts

    Directory of Open Access Journals (Sweden)

    Argo Nurbawono

    2012-05-01

    Full Text Available Superconducting point contacts have been used for measuring magnetic polarizations, identifying magnetic impurities, electronic structures, and even the vibrational modes of small molecules. Due to intrinsically small energy scale in the subgap structures of the supercurrent determined by the size of the superconducting energy gap, superconductors provide ultrahigh sensitivities for high resolution spectroscopies. The so-called Andreev reflection process between normal metal and superconductor carries complex and rich information which can be utilized as powerful sensor when fully exploited. In this review, we would discuss recent experimental and theoretical developments in the supercurrent transport through superconducting point contacts and their relevance to sensing applications, and we would highlight their current issues and potentials. A true utilization of the method based on Andreev reflection analysis opens up possibilities for a new class of ultrasensitive sensors.

  13. Point-of-Care Platforms

    Science.gov (United States)

    Gauglitz, Günter

    2014-06-01

    Point-of-care applications are gaining increasing interest in clinical diagnostics and emergency applications. Biosensors are used to monitor the biomolecular interaction process between a disease biomarker and a recognition element such as a reagent. Essential are the quality and selectivity of the recognition elements and assay types used to improve sensitivity and to avoid nonspecific interactions. In addition, quality measures are influenced by the detection principle and the evaluation strategies. For these reasons, this review provides a survey and validation of recognition elements, assays, and various types of detection methods for point-of-care testing (POCT) platforms. Common applications of clinical parameters are discussed and considered. In this ever-changing field, a snapshot of current applications is needed. We provide such a snapshot by way of a table including literature citations and also discuss these applications in more detail throughout.

  14. A Laboratory-Based Evaluation of Four Rapid Point-of-Care Tests for Syphilis

    Science.gov (United States)

    Causer, Louise M.; Kaldor, John M.; Fairley, Christopher K.; Donovan, Basil; Karapanagiotidis, Theo; Leslie, David E.; Robertson, Peter W.; McNulty, Anna M.; Anderson, David; Wand, Handan; Conway, Damian P.; Denham, Ian; Ryan, Claire; Guy, Rebecca J.

    2014-01-01

    Background Syphilis point-of-care tests may reduce morbidity and ongoing transmission by increasing the proportion of people rapidly treated. Syphilis stage and co-infection with HIV may influence test performance. We evaluated four commercially available syphilis point-of-care devices in a head-to-head comparison using sera from laboratories in Australia. Methods Point-of-care tests were evaluated using sera stored at Sydney and Melbourne laboratories. Sensitivity and specificity were calculated by standard methods, comparing point-of-care results to treponemal immunoassay (IA) reference test results. Additional analyses by clinical syphilis stage, HIV status, and non-treponemal antibody titre were performed. Non-overlapping 95% confidence intervals (CI) were considered statistically significant differences in estimates. Results In total 1203 specimens were tested (736 IA-reactive, 467 IA-nonreactive). Point-of-care test sensitivities were: Determine 97.3%(95%CI:95.8–98.3), Onsite 92.5%(90.3–94.3), DPP 89.8%(87.3–91.9) and Bioline 87.8%(85.1–90.0). Specificities were: Determine 96.4%(94.1–97.8), Onsite 92.5%(90.3–94.3), DPP 98.3%(96.5–99.2), and Bioline 98.5%(96.8–99.3). Sensitivity of the Determine test was 100% for primary and 100% for secondary syphilis. The three other tests had reduced sensitivity among primary (80.4–90.2%) compared to secondary syphilis (94.3–98.6%). No significant differences in sensitivity were observed by HIV status. Test sensitivities were significantly higher among high-RPR titre (RPR≥8) (range: 94.6–99.5%) than RPR non-reactive infections (range: 76.3–92.9%). Conclusions The Determine test had the highest sensitivity overall. All tests were most sensitive among high-RPR titre infections. Point-of-care tests have a role in syphilis control programs however in developed countries with established laboratory infrastructures, the lower sensitivities of some tests observed in primary syphilis suggest these would

  15. Characterization and simulation of fate and transport of selected volatile organic compounds in the vicinities of the Hadnot Point Industrial Area and landfill: Chapter A Supplement 6 in Analyses and historical reconstruction of groundwater flow, contaminant fate and transport, and distribution of drinking water within the service areas of the Hadnot Point and Holcomb Boulevard Water Treatment Plants and vicinities, U.S. Marine Corps Base Camp Lejeune, North Carolina

    Science.gov (United States)

    Jones, L. Elliott; Suárez-Soto, René J.; Anderson, Barbara A.; Maslia, Morris L.

    2013-01-01

    This supplement of Chapter A (Supplement 6) describes the reconstruction (i.e. simulation) of historical concentrations of tetrachloroethylene (PCE), trichloroethylene (TCE), and benzene3 in production wells supplying water to the Hadnot Base (USMCB) Camp Lejeune, North Carolina (Figure S6.1). A fate and transport model (i.e., MT3DMS [Zheng and Wang 1999]) was used to simulate contaminant migration from source locations through the groundwater system and to estimate mean contaminant concentrations in water withdrawn from water-supply wells in the vicinity of the Hadnot Point Industrial Area (HPIA) and the Hadnot Point landfill (HPLF) area.4 The reconstructed contaminant concentrations were subsequently input into a flow-weighted, materials mass balance (mixing) model (Masters 1998) to estimate monthly mean concentrations of the contaminant in finished water 5 at the HPWTP (Maslia et al. 2013). The calibrated fate and transport models described herein were based on and used groundwater velocities derived from groundwater-flow models that are described in Suárez-Soto et al. (2013). Information data pertinent to historical operations of water-supply wells are described in Sautner et al. (2013) and Telci et al. (2013).

  16. Periodic safety analyses

    International Nuclear Information System (INIS)

    Gouffon, A.; Zermizoglou, R.

    1990-12-01

    The IAEA Safety Guide 50-SG-S8 devoted to 'Safety Aspects of Foundations of Nuclear Power Plants' indicates that operator of a NPP should establish a program for inspection of safe operation during construction, start-up and service life of the plant for obtaining data needed for estimating the life time of structures and components. At the same time the program should ensure that the safety margins are appropriate. Periodic safety analysis are an important part of the safety inspection program. Periodic safety reports is a method for testing the whole system or a part of the safety system following the precise criteria. Periodic safety analyses are not meant for qualification of the plant components. Separate analyses are devoted to: start-up, qualification of components and materials, and aging. All these analyses are described in this presentation. The last chapter describes the experience obtained for PWR-900 and PWR-1300 units from 1986-1989

  17. Laser Beam Focus Analyser

    DEFF Research Database (Denmark)

    Nielsen, Peter Carøe; Hansen, Hans Nørgaard; Olsen, Flemming Ove

    2007-01-01

    the obtainable features in direct laser machining as well as heat affected zones in welding processes. This paper describes the development of a measuring unit capable of analysing beam shape and diameter of lasers to be used in manufacturing processes. The analyser is based on the principle of a rotating...... mechanical wire being swept through the laser beam at varying Z-heights. The reflected signal is analysed and the resulting beam profile determined. The development comprised the design of a flexible fixture capable of providing both rotation and Z-axis movement, control software including data capture...... and finally data analysis based on the ISO approach. The device was calibrated and tested on commercially available laser systems. It showed good reproducibility. It was the target to be able to measure CW lasers with a power up to 200 W, focused down to spot diameters in the range of 10µm. In order...

  18. Contesting Citizenship: Comparative Analyses

    DEFF Research Database (Denmark)

    Siim, Birte; Squires, Judith

    2007-01-01

    importance of particularized experiences and multiple ineequality agendas). These developments shape the way citizenship is both practiced and analysed. Mapping neat citizenship modles onto distinct nation-states and evaluating these in relation to formal equality is no longer an adequate approach....... Comparative citizenship analyses need to be considered in relation to multipleinequalities and their intersections and to multiple governance and trans-national organisinf. This, in turn, suggests that comparative citizenship analysis needs to consider new spaces in which struggles for equal citizenship occur...

  19. Dialogisk kommunikationsteoretisk analyse

    DEFF Research Database (Denmark)

    Phillips, Louise Jane

    2018-01-01

    analysemetode, der er blevet udviklet inden for dialogisk kommunikationsforskning - The Integrated Framework for Analysing Dialogic Knowledge Production and Communication (IFADIA). IFADIA-metoden bygger på en kombination af Bakhtins dialogteori og Foucaults teori om magt/viden og diskurs. Metoden er beregnet...

  20. Probabilistic safety analyses (PSA)

    International Nuclear Information System (INIS)

    1997-01-01

    The guide shows how the probabilistic safety analyses (PSA) are used in the design, construction and operation of light water reactor plants in order for their part to ensure that the safety of the plant is good enough in all plant operational states

  1. Meta-analyses

    NARCIS (Netherlands)

    Hendriks, Maria A.; Luyten, Johannes W.; Scheerens, Jaap; Sleegers, P.J.C.; Scheerens, J

    2014-01-01

    In this chapter results of a research synthesis and quantitative meta-analyses of three facets of time effects in education are presented, namely time at school during regular lesson hours, homework, and extended learning time. The number of studies for these three facets of time that could be used

  2. Analysing Access Control Specifications

    DEFF Research Database (Denmark)

    Probst, Christian W.; Hansen, René Rydhof

    2009-01-01

    . Recent events have revealed intimate knowledge of surveillance and control systems on the side of the attacker, making it often impossible to deduce the identity of an inside attacker from logged data. In this work we present an approach that analyses the access control configuration to identify the set...

  3. Wavelet Analyses and Applications

    Science.gov (United States)

    Bordeianu, Cristian C.; Landau, Rubin H.; Paez, Manuel J.

    2009-01-01

    It is shown how a modern extension of Fourier analysis known as wavelet analysis is applied to signals containing multiscale information. First, a continuous wavelet transform is used to analyse the spectrum of a nonstationary signal (one whose form changes in time). The spectral analysis of such a signal gives the strength of the signal in each…

  4. Filmstil - teori og analyse

    DEFF Research Database (Denmark)

    Hansen, Lennard Højbjerg

    Filmstil påvirker på afgørende vis vores oplevelse af film. Men filmstil, måden, de levende billeder organiserer fortællingen på fylder noget mindre end filmens handling, når vi taler om film. Filmstil - teori og analyse er en rigt eksemplificeret præsentation, kritik og videreudvikling af...

  5. Risico-analyse brandstofpontons

    NARCIS (Netherlands)

    Uijt de Haag P; Post J; LSO

    2001-01-01

    Voor het bepalen van de risico's van brandstofpontons in een jachthaven is een generieke risico-analyse uitgevoerd. Er is een referentiesysteem gedefinieerd, bestaande uit een betonnen brandstofponton met een relatief grote inhoud en doorzet. Aangenomen is dat de ponton gelegen is in een

  6. Metaharmonic Lattice Point Theory

    CERN Document Server

    Freeden, Willi

    2011-01-01

    Metaharmonic Lattice Point Theory covers interrelated methods and tools of spherically oriented geomathematics and periodically reflected analytic number theory. The book establishes multi-dimensional Euler and Poisson summation formulas corresponding to elliptic operators for the adaptive determination and calculation of formulas and identities of weighted lattice point numbers, in particular the non-uniform distribution of lattice points. The author explains how to obtain multi-dimensional generalizations of the Euler summation formula by interpreting classical Bernoulli polynomials as Green

  7. Parameter validation of analytical methods of insecticide residue analyses in foods of animal origin, feed and water.

    Science.gov (United States)

    Debebe, Amsalu; Kuttalam, S

    2011-06-01

    The study was conducted to examine the interrelationship and coherence of analytical parameters in method validation. Recovery, sensitivity, linearity, precision and limits of detection (LOD) were tested in six methods for organochlorine and organophosphate insecticides. Compounds that fell out of the stipulated recovery, 70-120%, in a matrix have concurrently failed to meet the requirements for sensitivity (≥ 0.7), linearity (R² > 0.99) and precision (< 0.2) in the same matrix. Highest LOD was recorded in those compounds and matrices. Different from the conventional point estimate, a new approach was introduced for setting upper and lower confidence limits of the LOD in quantitative analyses.

  8. Kantian Turning Point in Gadamer's Philosophical Hermeneutics

    Directory of Open Access Journals (Sweden)

    Kristína Bosáková

    2016-11-01

    Full Text Available The paper is treating the theme of a Kantian turning-point in the philosophical hermeneutics of H.- G. Gadamer based on of the harmonic relationship between metaphysics and science in Kantian philosophy from the point of view of the philosophical hermeneutics of Gadamer. The philosophical work of Kant had such an influence on Gadamer that without exaggerating we can talk about the Kantian turning-point in Gadamerian hermeneutics. Grondin, a former student of Gadamer, is talking about Kantian turning-point on the field of aesthetics, but in reality Kantian turning-point means much more than a mere change in the reception of the concept of judgement. It is a discovery of harmonical relationship between the beauty and the moral, between the reason and the sensitivity, between the modern sciences and the metaphysical tradition in the Kantian philosophy, made by Gadamer. This is what we call the Kantian turning-point in Gadamerian hermeneutics.

  9. The experienced temperature sensitivity and regulation survey

    Science.gov (United States)

    Van Someren, Eus J. W.; Dekker, Kim; Te Lindert, Bart H. W.; Benjamins, Jeroen S.; Moens, Sarah; Migliorati, Filippo; Aarts, Emmeke; van der Sluis, Sophie

    2016-01-01

    ABSTRACT Individuals differ in thermosensitivity, thermoregulation, and zones of thermoneutrality and thermal comfort. Whereas temperature sensing and -effectuating processes occur in part unconsciously and autonomic, awareness of temperature and thermal preferences can affect thermoregulatory behavior as well. Quantification of trait-like individual differences of thermal preferences and experienced temperature sensitivity and regulation is therefore relevant to obtain a complete understanding of human thermophysiology. Whereas several scales have been developed to assess instantaneous appreciation of heat and cold exposure, a comprehensive scale dedicated to assess subjectively experienced autonomic or behavioral thermoregulatory activity has been lacking so far. We constructed a survey that specifically approaches these domains from a trait-like perspective, sampled 240 volunteers across a wide age range, and analyzed the emergent component structure. Participants were asked to report their thermal experiences, captured in 102 questions, on a 7-point bi-directional Likert scale. In a second set of 32 questions, participants were asked to indicate the relative strength of experiences across different body locations. Principal component analyses extracted 21 meaningful dimensions, which were sensitive to sex-differences and age-related changes. The questions were also assessed in a matched sample of 240 people with probable insomnia to evaluate the sensitivity of these dimensions to detect group differences in a case-control design. The dimensions showed marked mean differences between cases and controls. The survey thus has discriminatory value. It can freely be used by anyone interested in studying individual or group differences in thermosensitivity and thermoregulation. PMID:27227080

  10. Interesting Interest Points

    DEFF Research Database (Denmark)

    Aanæs, Henrik; Dahl, Anders Lindbjerg; Pedersen, Kim Steenstrup

    2012-01-01

    Not all interest points are equally interesting. The most valuable interest points lead to optimal performance of the computer vision method in which they are employed. But a measure of this kind will be dependent on the chosen vision application. We propose a more general performance measure bas...

  11. Poisson branching point processes

    International Nuclear Information System (INIS)

    Matsuo, K.; Teich, M.C.; Saleh, B.E.A.

    1984-01-01

    We investigate the statistical properties of a special branching point process. The initial process is assumed to be a homogeneous Poisson point process (HPP). The initiating events at each branching stage are carried forward to the following stage. In addition, each initiating event independently contributes a nonstationary Poisson point process (whose rate is a specified function) located at that point. The additional contributions from all points of a given stage constitute a doubly stochastic Poisson point process (DSPP) whose rate is a filtered version of the initiating point process at that stage. The process studied is a generalization of a Poisson branching process in which random time delays are permitted in the generation of events. Particular attention is given to the limit in which the number of branching stages is infinite while the average number of added events per event of the previous stage is infinitesimal. In the special case when the branching is instantaneous this limit of continuous branching corresponds to the well-known Yule--Furry process with an initial Poisson population. The Poisson branching point process provides a useful description for many problems in various scientific disciplines, such as the behavior of electron multipliers, neutron chain reactions, and cosmic ray showers

  12. Indexing Moving Points

    DEFF Research Database (Denmark)

    Agarwal, Pankaj K.; Arge, Lars Allan; Erickson, Jeff

    2003-01-01

    We propose three indexing schemes for storing a set S of N points in the plane, each moving along a linear trajectory, so that any query of the following form can be answered quickly: Given a rectangle R and a real value t, report all K points of S that lie inside R at time t. We first present an...

  13. Model Breaking Points Conceptualized

    Science.gov (United States)

    Vig, Rozy; Murray, Eileen; Star, Jon R.

    2014-01-01

    Current curriculum initiatives (e.g., National Governors Association Center for Best Practices and Council of Chief State School Officers 2010) advocate that models be used in the mathematics classroom. However, despite their apparent promise, there comes a point when models break, a point in the mathematical problem space where the model cannot,…

  14. Multispectral Image Feature Points

    Directory of Open Access Journals (Sweden)

    Cristhian Aguilera

    2012-09-01

    Full Text Available This paper presents a novel feature point descriptor for the multispectral image case: Far-Infrared and Visible Spectrum images. It allows matching interest points on images of the same scene but acquired in different spectral bands. Initially, points of interest are detected on both images through a SIFT-like based scale space representation. Then, these points are characterized using an Edge Oriented Histogram (EOH descriptor. Finally, points of interest from multispectral images are matched by finding nearest couples using the information from the descriptor. The provided experimental results and comparisons with similar methods show both the validity of the proposed approach as well as the improvements it offers with respect to the current state-of-the-art.

  15. Biomass feedstock analyses

    Energy Technology Data Exchange (ETDEWEB)

    Wilen, C.; Moilanen, A.; Kurkela, E. [VTT Energy, Espoo (Finland). Energy Production Technologies

    1996-12-31

    The overall objectives of the project `Feasibility of electricity production from biomass by pressurized gasification systems` within the EC Research Programme JOULE II were to evaluate the potential of advanced power production systems based on biomass gasification and to study the technical and economic feasibility of these new processes with different type of biomass feed stocks. This report was prepared as part of this R and D project. The objectives of this task were to perform fuel analyses of potential woody and herbaceous biomasses with specific regard to the gasification properties of the selected feed stocks. The analyses of 15 Scandinavian and European biomass feed stock included density, proximate and ultimate analyses, trace compounds, ash composition and fusion behaviour in oxidizing and reducing atmospheres. The wood-derived fuels, such as whole-tree chips, forest residues, bark and to some extent willow, can be expected to have good gasification properties. Difficulties caused by ash fusion and sintering in straw combustion and gasification are generally known. The ash and alkali metal contents of the European biomasses harvested in Italy resembled those of the Nordic straws, and it is expected that they behave to a great extent as straw in gasification. Any direct relation between the ash fusion behavior (determined according to the standard method) and, for instance, the alkali metal content was not found in the laboratory determinations. A more profound characterisation of the fuels would require gasification experiments in a thermobalance and a PDU (Process development Unit) rig. (orig.) (10 refs.)

  16. Possible future HERA analyses

    International Nuclear Information System (INIS)

    Geiser, Achim

    2015-12-01

    A variety of possible future analyses of HERA data in the context of the HERA data preservation programme is collected, motivated, and commented. The focus is placed on possible future analyses of the existing ep collider data and their physics scope. Comparisons to the original scope of the HERA pro- gramme are made, and cross references to topics also covered by other participants of the workshop are given. This includes topics on QCD, proton structure, diffraction, jets, hadronic final states, heavy flavours, electroweak physics, and the application of related theory and phenomenology topics like NNLO QCD calculations, low-x related models, nonperturbative QCD aspects, and electroweak radiative corrections. Synergies with other collider programmes are also addressed. In summary, the range of physics topics which can still be uniquely covered using the existing data is very broad and of considerable physics interest, often matching the interest of results from colliders currently in operation. Due to well-established data and MC sets, calibrations, and analysis procedures the manpower and expertise needed for a particular analysis is often very much smaller than that needed for an ongoing experiment. Since centrally funded manpower to carry out such analyses is not available any longer, this contribution not only targets experienced self-funded experimentalists, but also theorists and master-level students who might wish to carry out such an analysis.

  17. Sensitivity, Recalculated

    Energy Technology Data Exchange (ETDEWEB)

    Brodsky, J. P. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2016-11-07

    Prior to this study, the sensitivity in nEXO was calculated using an approximate method that does not provide 90% coverage. I find it useful to understand the confidence level of a limit by focusing on the confidence level as a property of the method used to find the limit.A particular method (algorithm,formula) is applied to an experiment to produce a limit. That experiment was conducted in a particular universe with certain values of the physical parameters. We’d like a method than produces a correct limit for 90% of the experiments that could run. We also want that to be true for every universe—that is, regardless of the physical parameter value, the method should still produce a correct limit 90% of the time.

  18. Dandelions, tulips and orchids: evidence for the existence of low-sensitive, medium-sensitive and high-sensitive individuals.

    Science.gov (United States)

    Lionetti, Francesca; Aron, Arthur; Aron, Elaine N; Burns, G Leonard; Jagiellowicz, Jadzia; Pluess, Michael

    2018-01-22

    According to empirical studies and recent theories, people differ substantially in their reactivity or sensitivity to environmental influences with some being generally more affected than others. More sensitive individuals have been described as orchids and less-sensitive ones as dandelions. Applying a data-driven approach, we explored the existence of sensitivity groups in a sample of 906 adults who completed the highly sensitive person (HSP) scale. According to factor analyses, the HSP scale reflects a bifactor model with a general sensitivity factor. In contrast to prevailing theories, latent class analyses consistently suggested the existence of three rather than two groups. While we were able to identify a highly sensitive (orchids, 31%) and a low-sensitive group (dandelions, 29%), we also detected a third group (40%) characterised by medium sensitivity, which we refer to as tulips in keeping with the flower metaphor. Preliminary cut-off scores for all three groups are provided. In order to characterise the different sensitivity groups, we investigated group differences regarding the Big Five personality traits, as well as experimentally assessed emotional reactivity in an additional independent sample. According to these follow-up analyses, the three groups differed in neuroticism, extraversion and emotional reactivity to positive mood induction with orchids scoring significantly higher in neuroticism and emotional reactivity and lower in extraversion than the other two groups (dandelions also differed significantly from tulips). Findings suggest that environmental sensitivity is a continuous and normally distributed trait but that people fall into three distinct sensitive groups along a sensitivity continuum.

  19. A systematic evaluation of immunoassay point-of-care testing to define impact on patients' outcomes.

    Science.gov (United States)

    Pecoraro, Valentina; Banfi, Giuseppe; Germagnoli, Luca; Trenti, Tommaso

    2017-07-01

    Background Point-of-care testing has been developed to provide rapid test results. Most published studies focus on analytical performance, neglecting its impact on patient outcomes. Objective To review the analytical performance and accuracy of point-of-care testing specifically planned for immunoassay and to evaluate the impact of faster results on patient management. Methods A search of electronic databases for studies reporting immunoassay results obtained in both point-of-care testing and central laboratory scenarios was performed. Data were extracted concerning the study details, and the methodological quality was assessed. The analytical characteristics and diagnostic accuracy of six points-of-care testing: troponin, procalcitonin, parathyroid hormone, brain natriuretic peptide, C-reactive protein and neutrophil gelatinase-associated lipocalin were evaluated. Results A total of 116 scientific papers were analysed. Studies measuring procalcitonin, parathyroid hormone and neutrophil gelatinase-associated lipocalin reported a limited impact on diagnostic decisions. Seven studies measuring C-reactive protein claimed a significant reduction of antibiotic prescription. Several authors evaluated brain natriuretic peptide or troponin reporting faster decision-making without any improvement in clinical outcome. Forty-four per cent of studies reported analytical data, showing satisfactory correlations between results obtained through point-of-care testing and central laboratory setting. Half of studies defined the diagnostic accuracy of point-of-care testing as acceptable for troponin (median sensitivity and specificity: 74% and 94%, respectively), brain natriuretic peptide (median sensitivity and specificity: 82% and 88%, respectively) and C-reactive protein (median sensitivity and specificity 85%). Conclusions Point-of-care testing immunoassay results seem to be reliable and accurate for troponin, brain natriuretic peptide and C-reactive protein. The satisfactory

  20. Do acupuncture points exist?

    International Nuclear Information System (INIS)

    Yan Xiaohui; Zhang Xinyi; Liu Chenglin; Dang, Ruishan; Huang Yuying; He Wei; Ding Guanghong

    2009-01-01

    We used synchrotron x-ray fluorescence analysis to probe the distribution of four chemical elements in and around acupuncture points, two located in the forearm and two in the lower leg. Three of the four acupuncture points showed significantly elevated concentrations of elements Ca, Fe, Cu and Zn in relation to levels in the surrounding tissue, with similar elevation ratios for Cu and Fe. The mapped distribution of these elements implies that each acupuncture point seems to be elliptical with the long axis along the meridian. (note)

  1. Do acupuncture points exist?

    Energy Technology Data Exchange (ETDEWEB)

    Yan Xiaohui; Zhang Xinyi [Department of Physics, Surface Physics Laboratory (State Key Laboratory), and Synchrotron Radiation Research Center of Fudan University, Shanghai 200433 (China); Liu Chenglin [Physics Department of Yancheng Teachers' College, Yancheng 224002 (China); Dang, Ruishan [Second Military Medical University, Shanghai 200433 (China); Huang Yuying; He Wei [Beijing Synchrotron Radiation Facility, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100039 (China); Ding Guanghong [Shanghai Research Center of Acupuncture and Meridian, Pudong, Shanghai 201203 (China)

    2009-05-07

    We used synchrotron x-ray fluorescence analysis to probe the distribution of four chemical elements in and around acupuncture points, two located in the forearm and two in the lower leg. Three of the four acupuncture points showed significantly elevated concentrations of elements Ca, Fe, Cu and Zn in relation to levels in the surrounding tissue, with similar elevation ratios for Cu and Fe. The mapped distribution of these elements implies that each acupuncture point seems to be elliptical with the long axis along the meridian. (note)

  2. AMS analyses at ANSTO

    International Nuclear Information System (INIS)

    Lawson, E.M.

    1998-01-01

    The major use of ANTARES is Accelerator Mass Spectrometry (AMS) with 14 C being the most commonly analysed radioisotope - presently about 35 % of the available beam time on ANTARES is used for 14 C measurements. The accelerator measurements are supported by, and dependent on, a strong sample preparation section. The ANTARES AMS facility supports a wide range of investigations into fields such as global climate change, ice cores, oceanography, dendrochronology, anthropology, and classical and Australian archaeology. Described here are some examples of the ways in which AMS has been applied to support research into the archaeology, prehistory and culture of this continent's indigenous Aboriginal peoples. (author)

  3. Point/Counterpoint

    DEFF Research Database (Denmark)

    Ungar, David; Ernst, Erik

    2007-01-01

    Point Argument: "Dynamic Languages (in Reactive Environments) Unleash Creativity," by David Ungar. For the sake of creativity, the profession needs to concentrate more on inventing new and better dynamic languages and environments and less on improving static languages. Counterpoint Argument...

  4. Bedrock Outcrop Points Compilation

    Data.gov (United States)

    Vermont Center for Geographic Information — A compilation of bedrock outcrops as points and/or polygons from 1:62,500 and 1:24,000 geologic mapping by the Vermont Geological Survey, the United States...

  5. Triple Point Topological Metals

    Directory of Open Access Journals (Sweden)

    Ziming Zhu

    2016-07-01

    Full Text Available Topologically protected fermionic quasiparticles appear in metals, where band degeneracies occur at the Fermi level, dictated by the band structure topology. While in some metals these quasiparticles are direct analogues of elementary fermionic particles of the relativistic quantum field theory, other metals can have symmetries that give rise to quasiparticles, fundamentally different from those known in high-energy physics. Here, we report on a new type of topological quasiparticles—triple point fermions—realized in metals with symmorphic crystal structure, which host crossings of three bands in the vicinity of the Fermi level protected by point group symmetries. We find two topologically different types of triple point fermions, both distinct from any other topological quasiparticles reported to date. We provide examples of existing materials that host triple point fermions of both types and discuss a variety of physical phenomena associated with these quasiparticles, such as the occurrence of topological surface Fermi arcs, transport anomalies, and topological Lifshitz transitions.

  6. National Wetlands Inventory Points

    Data.gov (United States)

    Minnesota Department of Natural Resources — Wetland point features (typically wetlands that are too small to be as area features at the data scale) mapped as part of the National Wetlands Inventory (NWI). The...

  7. Allegheny County Address Points

    Data.gov (United States)

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — This dataset contains address points which represent physical address locations assigned by the Allegheny County addressing authority. Data is updated by County...

  8. Designated Wildlife Lakes - points

    Data.gov (United States)

    Minnesota Department of Natural Resources — This is a point shapefile of Designated Wildlife Lakes in Minnesota. This shapefile was created by converting lake polygons from the Designated Wildlife Lakes...

  9. Arctic climate tipping points.

    Science.gov (United States)

    Lenton, Timothy M

    2012-02-01

    There is widespread concern that anthropogenic global warming will trigger Arctic climate tipping points. The Arctic has a long history of natural, abrupt climate changes, which together with current observations and model projections, can help us to identify which parts of the Arctic climate system might pass future tipping points. Here the climate tipping points are defined, noting that not all of them involve bifurcations leading to irreversible change. Past abrupt climate changes in the Arctic are briefly reviewed. Then, the current behaviour of a range of Arctic systems is summarised. Looking ahead, a range of potential tipping phenomena are described. This leads to a revised and expanded list of potential Arctic climate tipping elements, whose likelihood is assessed, in terms of how much warming will be required to tip them. Finally, the available responses are considered, especially the prospects for avoiding Arctic climate tipping points.

  10. Dynamic Pointing Triggers Shifts of Visual Attention in Young Infants

    Science.gov (United States)

    Rohlfing, Katharina J.; Longo, Matthew R.; Bertenthal, Bennett I.

    2012-01-01

    Pointing, like eye gaze, is a deictic gesture that can be used to orient the attention of another person towards an object or an event. Previous research suggests that infants first begin to follow a pointing gesture between 10 and 13 months of age. We investigated whether sensitivity to pointing could be seen at younger ages employing a technique…

  11. Unconventional Quantum Critical Points

    OpenAIRE

    Xu, Cenke

    2012-01-01

    In this paper we review the theory of unconventional quantum critical points that are beyond the Landau's paradigm. Three types of unconventional quantum critical points will be discussed: (1). The transition between topological order and semiclassical spin ordered phase; (2). The transition between topological order and valence bond solid phase; (3). The direct second order transition between different competing orders. We focus on the field theory and universality class of these unconventio...

  12. Uncertainty Analyses and Strategy

    International Nuclear Information System (INIS)

    Kevin Coppersmith

    2001-01-01

    The DOE identified a variety of uncertainties, arising from different sources, during its assessment of the performance of a potential geologic repository at the Yucca Mountain site. In general, the number and detail of process models developed for the Yucca Mountain site, and the complex coupling among those models, make the direct incorporation of all uncertainties difficult. The DOE has addressed these issues in a number of ways using an approach to uncertainties that is focused on producing a defensible evaluation of the performance of a potential repository. The treatment of uncertainties oriented toward defensible assessments has led to analyses and models with so-called ''conservative'' assumptions and parameter bounds, where conservative implies lower performance than might be demonstrated with a more realistic representation. The varying maturity of the analyses and models, and uneven level of data availability, result in total system level analyses with a mix of realistic and conservative estimates (for both probabilistic representations and single values). That is, some inputs have realistically represented uncertainties, and others are conservatively estimated or bounded. However, this approach is consistent with the ''reasonable assurance'' approach to compliance demonstration, which was called for in the U.S. Nuclear Regulatory Commission's (NRC) proposed 10 CFR Part 63 regulation (64 FR 8640 [DIRS 101680]). A risk analysis that includes conservatism in the inputs will result in conservative risk estimates. Therefore, the approach taken for the Total System Performance Assessment for the Site Recommendation (TSPA-SR) provides a reasonable representation of processes and conservatism for purposes of site recommendation. However, mixing unknown degrees of conservatism in models and parameter representations reduces the transparency of the analysis and makes the development of coherent and consistent probability statements about projected repository

  13. Properties of residuals for spatial point processes

    DEFF Research Database (Denmark)

    Baddeley, A.; Møller, Jesper; Pakes, A.G.

    For any point process in $R^d$ that has a Papangelou conditional intensity $lambda$, we define a random measure of ‘innovations’ which has mean zero. When the point process model parameters are estimated from data, there is an analogous random measure of ‘residuals’. We analyse properties of the ...... of the innovations and residuals, including first and second moments, conditional independence, a martingale property, lack of correlation, and marginal distributions....

  14. Maternal sensitivity: a concept analysis.

    Science.gov (United States)

    Shin, Hyunjeong; Park, Young-Joo; Ryu, Hosihn; Seomun, Gyeong-Ae

    2008-11-01

    The aim of this paper is to report a concept analysis of maternal sensitivity. Maternal sensitivity is a broad concept encompassing a variety of interrelated affective and behavioural caregiving attributes. It is used interchangeably with the terms maternal responsiveness or maternal competency, with no consistency of use. There is a need to clarify the concept of maternal sensitivity for research and practice. A search was performed on the CINAHL and Ovid MEDLINE databases using 'maternal sensitivity', 'maternal responsiveness' and 'sensitive mothering' as key words. The searches yielded 54 records for the years 1981-2007. Rodgers' method of evolutionary concept analysis was used to analyse the material. Four critical attributes of maternal sensitivity were identified: (a) dynamic process involving maternal abilities; (b) reciprocal give-and-take with the infant; (c) contingency on the infant's behaviour and (d) quality of maternal behaviours. Maternal identity and infant's needs and cues are antecedents for these attributes. The consequences are infant's comfort, mother-infant attachment and infant development. In addition, three positive affecting factors (social support, maternal-foetal attachment and high self-esteem) and three negative affecting factors (maternal depression, maternal stress and maternal anxiety) were identified. A clear understanding of the concept of maternal sensitivity could be useful for developing ways to enhance maternal sensitivity and to maximize the developmental potential of infants. Knowledge of the attributes of maternal sensitivity identified in this concept analysis may be helpful for constructing measuring items or dimensions.

  15. EEG analyses with SOBI.

    Energy Technology Data Exchange (ETDEWEB)

    Glickman, Matthew R.; Tang, Akaysha (University of New Mexico, Albuquerque, NM)

    2009-02-01

    The motivating vision behind Sandia's MENTOR/PAL LDRD project has been that of systems which use real-time psychophysiological data to support and enhance human performance, both individually and of groups. Relevant and significant psychophysiological data being a necessary prerequisite to such systems, this LDRD has focused on identifying and refining such signals. The project has focused in particular on EEG (electroencephalogram) data as a promising candidate signal because it (potentially) provides a broad window on brain activity with relatively low cost and logistical constraints. We report here on two analyses performed on EEG data collected in this project using the SOBI (Second Order Blind Identification) algorithm to identify two independent sources of brain activity: one in the frontal lobe and one in the occipital. The first study looks at directional influences between the two components, while the second study looks at inferring gender based upon the frontal component.

  16. A simple beam analyser

    International Nuclear Information System (INIS)

    Lemarchand, G.

    1977-01-01

    (ee'p) experiments allow to measure the missing energy distribution as well as the momentum distribution of the extracted proton in the nucleus versus the missing energy. Such experiments are presently conducted on SACLAY's A.L.S. 300 Linac. Electrons and protons are respectively analysed by two spectrometers and detected in their focal planes. Counting rates are usually low and include time coincidences and accidentals. Signal-to-noise ratio is dependent on the physics of the experiment and the resolution of the coincidence, therefore it is mandatory to get a beam current distribution as flat as possible. Using new technologies has allowed to monitor in real time the behavior of the beam pulse and determine when the duty cycle can be considered as being good with respect to a numerical basis

  17. Analyse af elbilers forbrug

    DEFF Research Database (Denmark)

    Andersen, Ove; Krogh, Benjamin Bjerre; Torp, Kristian

    2014-01-01

    Denne rapport undersøger GPS og CAN bus datagrundlaget opsamlet ved kørsel med elbiler og analysere på elbilers forbrug. Analyserne er baseret på godt 133 millioner GPS og CAN bus målinger opsamlet fra 164 elbiler (Citroen C-Zero, Mitsubishi iMiev og Peugeot Ion) i kalenderåret 2012....... For datagrundlaget kan det konstateres, at der er behov for væsentlige, men simple opstramninger for fremadrettet at gøre det nemmere at anvende GPS/CAN bus data fra elbiler i andre analyser. Brugen af elbiler er sammenlignet med brændstofbiler og konklusionen er, at elbiler generelt kører 10-15 km/t langsommere på...

  18. Analyse de "La banlieue"

    Directory of Open Access Journals (Sweden)

    Nelly Morais

    2006-11-01

    Full Text Available 1. Préambule - Conditions de réalisation de la présente analyse Un groupe d'étudiants de master 1 de FLE de l'université Paris 3 (donc des étudiants en didactique des langues se destinant à l'enseignement du FLE a observé le produit au cours d'un module sur les TIC (Technologies de l'Information et de la Communication et la didactique des langues. Une discussion s'est ensuite engagée sur le forum d'une plate-forme de formation à distance à partir de quelques questions posées par l'enseigna...

  19. Fundamental data analyses for measurement control

    International Nuclear Information System (INIS)

    Campbell, K.; Barlich, G.L.; Fazal, B.; Strittmatter, R.B.

    1987-02-01

    A set of measurment control data analyses was selected for use by analysts responsible for maintaining measurement quality of nuclear materials accounting instrumentation. The analyses consist of control charts for bias and precision and statistical tests used as analytic supplements to the control charts. They provide the desired detection sensitivity and yet can be interpreted locally, quickly, and easily. The control charts provide for visual inspection of data and enable an alert reviewer to spot problems possibly before statistical tests detect them. The statistical tests are useful for automating the detection of departures from the controlled state or from the underlying assumptions (such as normality). 8 refs., 3 figs., 5 tabs

  20. Characterization of MIPAS elevation pointing

    Directory of Open Access Journals (Sweden)

    M. Kiefer

    2007-01-01

    Full Text Available Sufficient knowledge of the pointing is essential for analyses of limb emission measurements. The scientific retrieval processor for MIPAS on ENVISAT operated at IMK allows the retrieval of pointing information in terms of tangent altitudes along with temperature. The retrieved tangent altitudes are independent of systematic offsets in the engineering Line-Of-Sight (LOS information delivered with the ESA Level 1b product. The difference of pointing retrieved from the reprocessed high resolution MIPAS spectra and the engineering pointing information was examined with respect to spatial/temporal behaviour. Among others the following characteristics of MIPAS pointing could be identified: Generally the engineering tangent altitudes are too high by 0–1.8 km with conspicuous variations in this range over time. Prior to December of 2003 there was a drift of about 50–100 m/h, which was due to a slow change in the satellite attitude. A correction of this attitude is done twice a day, which leads to discontinuities in the order of 1–1.5 km in the tangent altitudes. Occasionally discontinuities up to 2.5 km are found, as already reported from MIPAS and SCIAMACHY observations. After an update of the orbit position software in December 2003 values of drift and jumps are much reduced. There is a systematic difference in the mispointing between the poles which amounts to 1.5–2 km, i.e. there is a conspicuous orbit-periodic feature. The analysis of the correlation between the instrument's viewing angle azimuth and differential mispointing supports the hypotheses that a major part of this latter phenomenon can be attributed to an error in the roll angle of the satellite/instrument system of approximately 42 mdeg. One conclusion is that ESA level 2 data should be compared to other data exclusively on tangent pressure levels. Complementary to IMK data, ESA operational LOS calibration results were used to characterize MIPAS pointing. For this purpose

  1. Seismic fragility analyses

    International Nuclear Information System (INIS)

    Kostov, Marin

    2000-01-01

    In the last two decades there is increasing number of probabilistic seismic risk assessments performed. The basic ideas of the procedure for performing a Probabilistic Safety Analysis (PSA) of critical structures (NUREG/CR-2300, 1983) could be used also for normal industrial and residential buildings, dams or other structures. The general formulation of the risk assessment procedure applied in this investigation is presented in Franzini, et al., 1984. The probability of failure of a structure for an expected lifetime (for example 50 years) can be obtained from the annual frequency of failure, β E determined by the relation: β E ∫[d[β(x)]/dx]P(flx)dx. β(x) is the annual frequency of exceedance of load level x (for example, the variable x may be peak ground acceleration), P(fI x) is the conditional probability of structure failure at a given seismic load level x. The problem leads to the assessment of the seismic hazard β(x) and the fragility P(fl x). The seismic hazard curves are obtained by the probabilistic seismic hazard analysis. The fragility curves are obtained after the response of the structure is defined as probabilistic and its capacity and the associated uncertainties are assessed. Finally the fragility curves are combined with the seismic loading to estimate the frequency of failure for each critical scenario. The frequency of failure due to seismic event is presented by the scenario with the highest frequency. The tools usually applied for probabilistic safety analyses of critical structures could relatively easily be adopted to ordinary structures. The key problems are the seismic hazard definitions and the fragility analyses. The fragility could be derived either based on scaling procedures or on the base of generation. Both approaches have been presented in the paper. After the seismic risk (in terms of failure probability) is assessed there are several approaches for risk reduction. Generally the methods could be classified in two groups. The

  2. Cloud Point Depressants

    OpenAIRE

    Ali, Hassan

    2012-01-01

    Wax formation and deposition in subsea crude oil piepline is most important problem in cold environments faced by petroleum industry. Significant research is been going on at industrial as well as academic levels to develop additives which are able to break the wax crystal structure or at least weakens it. Addition of cloud point depressants has been found to be an effective way of dealing with waxes. The main focus of this project is chemical control of wax gel formation by using cloud point...

  3. Website-analyse

    DEFF Research Database (Denmark)

    Thorlacius, Lisbeth

    2009-01-01

    eller blindgyder, når han/hun besøger sitet. Studier i design og analyse af de visuelle og æstetiske aspekter i planlægning og brug af websites har imidlertid kun i et begrænset omfang været under reflektorisk behandling. Det er baggrunden for dette kapitel, som indleder med en gennemgang af æstetikkens......Websitet er i stigende grad det foretrukne medie inden for informationssøgning,virksomhedspræsentation, e-handel, underholdning, undervisning og social kontakt. I takt med denne voksende mangfoldighed af kommunikationsaktiviteter på nettet, er der kommet mere fokus på at optimere design og...... planlægning af de funktionelle og indholdsmæssige aspekter ved websites. Der findes en stor mængde teori- og metodebøger, som har specialiseret sig i de tekniske problemstillinger i forbindelse med interaktion og navigation, samt det sproglige indhold på websites. Den danske HCI (Human Computer Interaction...

  4. A channel profile analyser

    International Nuclear Information System (INIS)

    Gobbur, S.G.

    1983-01-01

    It is well understood that due to the wide band noise present in a nuclear analog-to-digital converter, events at the boundaries of adjacent channels are shared. It is a difficult and laborious process to exactly find out the shape of the channels at the boundaries. A simple scheme has been developed for the direct display of channel shape of any type of ADC on a cathode ray oscilliscope display. This has been accomplished by sequentially incrementing the reference voltage of a precision pulse generator by a fraction of a channel and storing ADC data in alternative memory locations of a multichannel pulse height analyser. Alternative channels are needed due to the sharing at the boundaries of channels. In the flat region of the profile alternate memory locations are channels with zero counts and channels with the full scale counts. At the boundaries all memory locations will have counts. The shape of this is a direct display of the channel boundaries. (orig.)

  5. Mutual long-term effects of school bullying, victimization, and justice sensitivity in adolescents.

    Science.gov (United States)

    Bondü, Rebecca; Rothmund, Tobias; Gollwitzer, Mario

    2016-04-01

    In the present study, we investigate long-term relations between experiences of aggression at school and the development of justice sensitivity as a personality disposition in adolescents. We assessed justice sensitivity (from the victim, observer, and perpetrator perspective), bullying, and victimization among 565 German 12- to 18-year-olds in a one-year longitudinal study with two measurement points. Latent path analyses revealed gender differences in long-term effects of bullying and victimization on observer sensitivity and victim sensitivity. Experiences of victimization at T1 predicted an increase in victim sensitivity among girls and a decrease in victim sensitivity among boys. Bullying behavior at T1 predicted an increase in victim sensitivity among boys and a decrease in observer sensitivity among girls. We did not find long-term effects of justice sensitivity on bullying and victimization. Our findings indicate that experiences of bullying and victimization have gender-specific influences on the development of moral personality dispositions in adolescents. Copyright © 2016 The Foundation for Professionals in Services for Adolescents. Published by Elsevier Ltd. All rights reserved.

  6. Father involvement, paternal sensitivity, and father-child attachment security in the first 3 years.

    Science.gov (United States)

    Brown, Geoffrey L; Mangelsdorf, Sarah C; Neff, Cynthia

    2012-06-01

    To reach a greater understanding of the early father-child attachment relationship, this study examined concurrent and longitudinal associations among father involvement, paternal sensitivity, and father-child attachment security at 13 months and 3 years of age. Analyses revealed few associations among these variables at 13 months of age, but involvement and sensitivity independently predicted father-child attachment security at age 3. Moreover, sensitivity moderated the association between involvement and attachment security at 3 years. Specifically, involvement was unrelated to attachment security when fathers were highly sensitive, but positively related to attachment security when fathers were relatively less sensitive. Father involvement was also moderately stable across the two time points, but paternal sensitivity was not. Furthermore, there was significant stability in father-child attachment security from 13 months to 3 years. Secure attachment at 13 months also predicted greater levels of paternal sensitivity at 3 years, with sensitivity at age 3 mediating the association between 13 month and 3 year attachment security. In sum, a secure father-child attachment relationship (a) was related to both quantity and quality of fathering behavior, (b) remained relatively stable across early childhood, and (c) predicted increased paternal sensitivity over time. These findings further our understanding of the correlates of early father-child attachment, and underscore the need to consider multiple domains of fathers' parenting and reciprocal relations between fathering behavior and father-child attachment security. PsycINFO Database Record (c) 2012 APA, all rights reserved.

  7. Phantom pain : A sensitivity analysis

    NARCIS (Netherlands)

    Borsje, Susanne; Bosmans, JC; Van der Schans, CP; Geertzen, JHB; Dijkstra, PU

    2004-01-01

    Purpose : To analyse how decisions to dichotomise the frequency and impediment of phantom pain into absent and present influence the outcome of studies by performing a sensitivity analysis on an existing database. Method : Five hundred and thirty-six subjects were recruited from the database of an

  8. PowerPoint Presentation

    Indian Academy of Sciences (India)

    Table of contents. PowerPoint Presentation · CHANDIPURA VIRUS · Slide 3 · Slide 4 · Slide 5 · VIRUSES · PROPERTIES OF VIRUSES · CLASSIFICATION OF VIRUSES · VIRUS FAMILIES · VIRUS FAMILIES – contd · General Classification · Slide 12 · Slide 13 · Slide 14 · Slide 15 · Slide 16 · Slide 17 · Slide 18 · Slide 19.

  9. Building Temperature Set Point

    Energy Technology Data Exchange (ETDEWEB)

    Meincke, Carol L. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Evans, Christopher A. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2014-09-01

    This white paper provides information and recommendations for an actionable and enforceable corporate policy statement on temperature set points for office and related spaces at Sandia and presents a strategy that balances the need to achieve the energy goals with optimizing employee comfort and productivity.

  10. Point Lepreau generating station

    International Nuclear Information System (INIS)

    Ganong, G.H.D.; Strang, A.E.; Gunter, G.E.; Thompson, T.S.

    Point Lepreau-1 reactor is a 600 MWe generating station expected to be in service by October 1979. New Brunswick is suffering a 'catch up' phenomenon in load growth and needs to decrease dependence on foreign oil. The site is on salt water and extensive study has gone into corrosion control. Project management, financing and scheduling have unique aspects. (E.C.B.)

  11. PowerPoint Presentation

    Indian Academy of Sciences (India)

    Table of contents. PowerPoint Presentation · Slide 2 · Receptor-mediated endocytosis · Slide 4 · Publications – Direct therapeutic approaches · Importance of ECM recognition · Publications – ECM interactions · Slide 8 · L. donovani, when attached to the macrophage surface, behaves like any other microbe which are killed ...

  12. Publication point indicators

    DEFF Research Database (Denmark)

    Elleby, Anita; Ingwersen, Peter

    2010-01-01

    with novel publication point indicators (PPIs) that are formalized and exemplified. Two diachronic citation windows are applied: 2006-07 and 2006-08. Web of Science (WoS) as well as Google Scholar (GS) are applied to observe the cite delay and citedness for the different document types published by DIIS...

  13. Holographic Three point Functions

    DEFF Research Database (Denmark)

    Martirosyan, Ara

    . In the spirit of understanding this problem better, the thesis discusses the divergences appearing in the calculation of structure constants involving two giant and one point-like gravitons in the string theories on AdS_5 x S^5 and AdS_4 x S^7/Z_k backgrounds. Coherent state approach for the tree-level...

  14. New Novae snack point

    CERN Multimedia

    2012-01-01

    Located next to the car park by the flag poles, a few metres from the Main CERN Reception (building 33), a new snack point catered by Novae will open to the public on Wednesday 8 August. More information will be available in the next issue of the Bulletin!

  15. Hillclimbing saddle point inflation

    Science.gov (United States)

    Kawana, Kiyoharu; Sakai, Katsuta

    2018-03-01

    Recently a new inflationary scenario was proposed in [1] which can be applicable to an inflaton having multiple vacua. In this letter, we consider a more general situation where the inflaton potential has a (UV) saddle point around the Planck scale. This class of models can be regarded as a natural generalization of the hillclimbing Higgs inflation [2].

  16. Point kinetics modeling

    International Nuclear Information System (INIS)

    Kimpland, R.H.

    1996-01-01

    A normalized form of the point kinetics equations, a prompt jump approximation, and the Nordheim-Fuchs model are used to model nuclear systems. Reactivity feedback mechanisms considered include volumetric expansion, thermal neutron temperature effect, Doppler effect and void formation. A sample problem of an excursion occurring in a plutonium solution accidentally formed in a glovebox is presented

  17. Electro-sensitivity: the physicians-laymen relationship under the test of an environmental pathology

    International Nuclear Information System (INIS)

    Oullion, Amandine

    2014-01-01

    This academic work addresses sociological and anthropological aspects of contemporary techniques. The authors more particularly examined how electro-sensitivity contributes to the re-composition of the relationship between physicians and laymen. After some methodological and theoretical considerations, the authors first addresses this issue from a macro-sociological and political point of view, i.e. by discussing the role of laymen in the definition and addressing of public health issues. They analyse the implication of electro-sensitive persons in the process of politicisation of their disease, and in research arrangements implemented on these issues. Then, they address the way electro-sensitivity reshapes the meeting between physician and patient. In the last part, they address the way electro-sensitivity questions the medical institution itself in terms of medical practices, and of power relationships within this institution

  18. Layered Fixed Point Logic

    DEFF Research Database (Denmark)

    Filipiuk, Piotr; Nielson, Flemming; Nielson, Hanne Riis

    2012-01-01

    are a Moore Family result and a parametrized worst case time complexity result. We show that the logic and the associated solver can be used for rapid prototyping of analyses and illustrate a wide variety of applications within Static Analysis, Constraint Satisfaction Problems and Model Checking. In all cases...

  19. Risk Characterization uncertainties associated description, sensitivity analysis

    International Nuclear Information System (INIS)

    Carrillo, M.; Tovar, M.; Alvarez, J.; Arraez, M.; Hordziejewicz, I.; Loreto, I.

    2013-01-01

    The power point presentation is about risks to the estimated levels of exposure, uncertainty and variability in the analysis, sensitivity analysis, risks from exposure to multiple substances, formulation of guidelines for carcinogenic and genotoxic compounds and risk subpopulations

  20. Point of Care Ultrasound

    DEFF Research Database (Denmark)

    Dietrich, Christoph F; Goudie, Adrian; Chiorean, Liliana

    2017-01-01

    Over the last decade, the use of portable ultrasound scanners has enhanced the concept of point of care ultrasound (PoC-US), namely, "ultrasound performed at the bedside and interpreted directly by the treating clinician." PoC-US is not a replacement for comprehensive ultrasound, but rather allow...... and critical care medicine, cardiology, anesthesiology, rheumatology, obstetrics, neonatology, gynecology, gastroenterology and many other applications. In the future, PoC-US will be more diverse than ever and be included in medical student training.......Over the last decade, the use of portable ultrasound scanners has enhanced the concept of point of care ultrasound (PoC-US), namely, "ultrasound performed at the bedside and interpreted directly by the treating clinician." PoC-US is not a replacement for comprehensive ultrasound, but rather allows...

  1. Precise Point Positioning

    DEFF Research Database (Denmark)

    Zhang, Xiaohong

    performance of point positioning for kinematic applications, the precise point positioning attracted a lot of attention and opened a new alternative door to kinematic positioning. In this report different tests have been done to evaluate the ability and accuracy of the software TriP in the kinematic...... and static case by using internal consistency (residuals, RMS, repeatability etc.), known coordinates, ground truth and double-differenced solutions. The kinematic GPS positioning accuracy using four different software systems has been investigated and tested by comparing the degree of agreement between...... the airborne lidar system misalignment angle by automating the matching of lidar data with ground truth. Kinematic GPS positioning has been widely used, but the available commercial software systems are normally only suitable for the short or medium range kinematic baseline. However, in polar areas, airborne...

  2. Point clouds in BIM

    Science.gov (United States)

    Antova, Gergana; Kunchev, Ivan; Mickrenska-Cherneva, Christina

    2016-10-01

    The representation of physical buildings in Building Information Models (BIM) has been a subject of research since four decades in the fields of Construction Informatics and GeoInformatics. The early digital representations of buildings mainly appeared as 3D drawings constructed by CAD software, and the 3D representation of the buildings was only geometric, while semantics and topology were out of modelling focus. On the other hand, less detailed building representations, with often focus on ‘outside’ representations were also found in form of 2D /2,5D GeoInformation models. Point clouds from 3D laser scanning data give a full and exact representation of the building geometry. The article presents different aspects and the benefits of using point clouds in BIM in the different stages of a lifecycle of a building.

  3. PowerPoint Presentation

    Indian Academy of Sciences (India)

    PowerPoint Presentation · Slide 2 · Slide 3 · Slide 4 · Slide 5 · Slide 6 · HABITAT TYPES & PRIMATE GROUPS · Slide 8 · Slide 9 · TOPOGRAPHY OF KARNATAKA · SOUTHERN PLATEAU · Slide 13 · Slide 14 · WESTERN GHATS · Slide 16 · Slide 17 · LARGE SQUIRRELS · Slide 19 · OPEN PLAINS · Slide 21 · Slide 22.

  4. PowerPoint Presentation

    Indian Academy of Sciences (India)

    PowerPoint Presentation · Slide 2 · Slide 3 · Getting Smart with Smart Windows! Slide 5 · Energy Crisis!! Total World Primary Energy Supply · “We Ride on Water!” Volume for storage of 4 kg H2 in different states · Slide 10 · Linkers make a Difference! Coordination Polymers · Principle Behind Formation of MOFs · Slide 14.

  5. PowerPoint Presentation

    Indian Academy of Sciences (India)

    Table of contents. PowerPoint Presentation · Slide 2 · Distribution of viral encephalitis · Slide 4 · Slide 5 · Slide 6 · Slide 7 · Slide 8 · Slide 9 · Slide 10 · Slide 11 · Slide 12 · Slide 13 · Slide 14 · Slide 15 · Slide 16 · Slide 17 · Slide 18 · Slide 19 · Slide 20 · Slide 21 · Slide 22 · Slide 23 · Status dystonicus in Japanese encephalitis.

  6. PowerPoint Presentation

    Indian Academy of Sciences (India)

    Table of contents. PowerPoint Presentation · Slide 2 · Slide 3 · Slide 4 · Slide 5 · Slide 6 · Slide 7 · Slide 8 · Slide 9 · Slide 10 · Slide 11 · Slide 12 · Slide 13 · Slide 14 · Slide 15 · Slide 16 · Slide 17 · Slide 18 · Slide 19 · Slide 20 · Slide 21 · Slide 22 · Slide 23 · Slide 24 · Slide 25.

  7. PowerPoint Presentation

    Indian Academy of Sciences (India)

    PowerPoint Presentation · Slide 2 · Slide 3 · Slide 4 · Slide 5 · Slide 6 · Slide 7 · Planck CMB sky map · Slide 9 · Planck Angular power spectrum · CMB Polarization spectra · Slide 12 · Slide 13 · Cosmological Parameters · Slide 15 · Slide 16 · Slide 17 · Slide 18 · Slide 19 · Hemispherical asymmetry · Modulation model of SI ...

  8. PowerPoint Presentation

    Indian Academy of Sciences (India)

    PowerPoint Presentation · Slide 2 · The Heat Engine of the Earth · Slide 4 · Volcanoes at various settings · Slide 6 · Why study carbonatites? Uniqueness of Carbonatites · Origin of Carbonatites · Slide 10 · Slide 11 · Slide 12 · Slide 13 · Primary Objectives · Methods/Tracers Used · Slide 16 · Slide 17 · Slide 18 · Slide 19.

  9. PowerPoint Presentation

    Indian Academy of Sciences (India)

    PowerPoint Presentation · Slide 2 · Slide 3 · Demands for Space Transportation Systems for the next 30 years · Slide 5 · Slide 6 · Launch demand & costs · Slide 8 · Slide 9 · Slide 10 · Slide 11 · Slide 12 · Slide 13 · Slide 14 · Slide 15 · Slide 16 · Slide 17 · Slide 18 · Slide 19 · Slide 20 · Slide 21 · Slide 22 · Slide 23 · Slide 24.

  10. Mise au point

    African Journals Online (AJOL)

    7 mai 2012 ... cervico-thoracique confirme l'existence d'un goitre plon- geant aux dépens du lobe droit restant à 15 mm de la crosse aortique associé à un processus expansif tissulai- ... DU CANCER DIFFERENCIE DE LA ThYROIDE. R. BEN M'hAMED et al. Journal ORL N°26 .ai:Mise au point 07/05/12 09:45 page54 ...

  11. Critical point predication device

    International Nuclear Information System (INIS)

    Matsumura, Kazuhiko; Kariyama, Koji.

    1996-01-01

    An operation for predicting a critical point by using a existent reverse multiplication method has been complicated, and an effective multiplication factor could not be plotted directly to degrade the accuracy for the prediction. The present invention comprises a detector counting memory section for memorizing the counting sent from a power detector which monitors the reactor power, a reverse multiplication factor calculation section for calculating the reverse multiplication factor based on initial countings and current countings of the power detector, and a critical point prediction section for predicting the criticality by the reverse multiplication method relative to effective multiplication factors corresponding to the state of the reactor core previously determined depending on the cases. In addition, a reactor core characteristic calculation section is added for analyzing an effective multiplication factor depending on the state of the reactor core. Then, if the margin up to the criticality is reduced to lower than a predetermined value during critical operation, an alarm is generated to stop the critical operation when generation of a period of more than a predetermined value predicted by succeeding critical operation. With such procedures, forecasting for the critical point can be easily predicted upon critical operation to greatly mitigate an operator's burden and improve handling for the operation. (N.H.)

  12. Cost-effectiveness of point-of-care testing for dehydration in the pediatric ED.

    Science.gov (United States)

    Whitney, Rachel E; Santucci, Karen; Hsiao, Allen; Chen, Lei

    2016-08-01

    Acute gastroenteritis (AGE) and subsequent dehydration account for a large proportion of pediatric emergency department (PED) visits. Point-of-care (POC) testing has been used in conjunction with clinical assessment to determine the degree of dehydration. Despite the wide acceptance of POC testing, little formal cost-effective analysis of POC testing in the PED exists. We aim to examine the cost-effectiveness of using POC electrolyte testing vs traditional serum chemistry testing in the PED for children with AGE. This was a cost-effective analysis using data from a randomized control trial of children with AGE. A decision analysis model was constructed to calculate cost-savings from the point of view of the payer and the provider. We used parameters obtained from the trial, including cost of testing, admission rates, cost of admission, and length of stay. Sensitivity analyses were performed to evaluate the stability of our model. Using the data set of 225 subjects, POC testing results in a cost savings of $303.30 per patient compared with traditional serum testing from the point of the view of the payer. From the point-of-view of the provider, POC testing results in consistent mean savings of $36.32 ($8.29-$64.35) per patient. Sensitivity analyses demonstrated the stability of the model and consistent savings. This decision analysis provides evidence that POC testing in children with gastroenteritis-related moderate dehydration results in significant cost savings from the points of view of payers and providers compared to traditional serum chemistry testing. Copyright © 2016 Elsevier Inc. All rights reserved.

  13. Analysis of Consumers' Preferences and Price Sensitivity to Native Chickens.

    Science.gov (United States)

    Lee, Min-A; Jung, Yoojin; Jo, Cheorun; Park, Ji-Young; Nam, Ki-Chang

    2017-01-01

    This study analyzed consumers' preferences and price sensitivity to native chickens. A survey was conducted from Jan 6 to 17, 2014, and data were collected from consumers (n=500) living in Korea. Statistical analyses evaluated the consumption patterns of native chickens, preference marketing for native chicken breeds which will be newly developed, and price sensitivity measurement (PSM). Of the subjects who preferred broilers, 24.3% do not purchase native chickens because of the dryness and tough texture, while those who preferred native chickens liked their chewy texture (38.2%). Of the total subjects, 38.2% preferred fried native chickens (38.2%) for processed food, 38.4% preferred direct sales for native chicken distribution, 51.0% preferred native chickens to be slaughtered in specialty stores, and 32.4% wanted easy access to native chickens. Additionally, the price stress range (PSR) was 50 won and the point of marginal cheapness (PMC) and point of marginal expensiveness (PME) were 6,980 won and 12,300 won, respectively. Evaluation of the segmentation market revealed that consumers who prefer broiler to native chicken breeds were more sensitive to the chicken price. To accelerate the consumption of newly developed native chicken meat, it is necessary to develop a texture that each consumer needs, to increase the accessibility of native chickens, and to have diverse menus and recipes as well as reasonable pricing for native chickens.

  14. Inhibition effect of calcium hydroxide point and chlorhexidine point on root canal bacteria of necrosis teeth

    Directory of Open Access Journals (Sweden)

    Andry Leonard Je

    2006-03-01

    Full Text Available Calcium Hydroxide point and Chlorhexidine point are new drugs for eliminating bacteria in the root canal. The points slowly and controly realease Calcium Hydroxide and Chlorhexidine into root canal. The purpose of the study was to determined the effectivity of Calcium hydroxide point (Calcium hydroxide plus point and Chlorhexidine point in eleminating the root canal bacteria of nescrosis teeth. In this study 14 subjects were divided into 2 groups. The first group was treated with Calcium hydroxide point and the second was treated with Chlorhexidine poin. The bacteriological sampling were measured with spectrofotometry. The Paired T Test analysis (before and after showed significant difference between the first and second group. The Independent T Test which analysed the effectivity of both groups had not showed significant difference. Although there was no significant difference in statistical test, the result of second group eliminate more bacteria than the first group. The present finding indicated that the use of Chlorhexidine point was better than Calcium hydroxide point in seven days period. The conclusion is Chlorhexidine point and Calcium hydroxide point as root canal medicament effectively eliminate root canal bacteria of necrosis teeth.

  15. Sensitivity to friction for primary explosives

    Energy Technology Data Exchange (ETDEWEB)

    Matyas, Robert, E-mail: robert.matyas@upce.cz [Institute of Energetic Materials, Faculty of Chemical Technology, University of Pardubice, Pardubice 532 10 (Czech Republic); Selesovsky, Jakub; Musil, Tomas [Institute of Energetic Materials, Faculty of Chemical Technology, University of Pardubice, Pardubice 532 10 (Czech Republic)

    2012-04-30

    Highlights: Black-Right-Pointing-Pointer The friction sensitivity of 14 samples of primary explosives was determined. Black-Right-Pointing-Pointer The same apparatus (small scale BAM) and the same method (probit analysis) was used. Black-Right-Pointing-Pointer The crystal shapes and sizes were documented with microscopy. Black-Right-Pointing-Pointer Almost all samples are less sensitive than lead azide, which is commercially used. Black-Right-Pointing-Pointer The organic peroxides (TATP, DADP, HMTD) are not as sensitive as often reported. - Abstract: The sensitivity to friction for a selection of primary explosives has been studied using a small BAM friction apparatus. The probit analysis was used for the construction of a sensitivity curve for each primary explosive tested. Two groups of primary explosives were chosen for measurement (a) the most commonly used industrially produced primary explosives (e.g. lead azide, tetrazene, dinol, lead styphnate) and (b) the most produced improvised primary explosives (e.g. triacetone triperoxide, hexamethylenetriperoxide diamine, mercury fulminate, acetylides of heavy metals). A knowledge of friction sensitivity is very important for determining manipulation safety for primary explosives. All the primary explosives tested were carefully characterised (synthesis procedure, shape and size of crystals). The sensitivity curves obtained represent a unique set of data, which cannot be found anywhere else in the available literature.

  16. Probabilistic derivation of the interspecies assessment factor for skin sensitization.

    NARCIS (Netherlands)

    Bil, W; Schuur, A G; Ezendam, J; Bokkers, B G H

    An interspecies sensitization assessment factor (SAF) is used in the quantitative risk assessment (QRA) for skin sensitization when a murine-based NESIL (No Expected Sensitization Induction Level) is taken as point of departure. Several studies showed that, on average, the murine sensitization

  17. Columbia River ESI: M_MAMPT (Marine Mammal Points)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains sensitive biological resource data for sea lions and harbor seals in Columbia River. Vector points in this data set represent locations of...

  18. American Samoa ESI: T_MAMPT (Terrestrial Mammal Points)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains sensitive biological resource data for bats in American Samoa. Vector points in this data set represent bat roosts and caves. Species-specific...

  19. Hawaii ESI: M_MAMPT (Marine Mammal Points)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains sensitive biological resource data for endangered Hawaiian monk seal pupping and haul-out sites. Vector points in this data set represent...

  20. Tipping point leadership.

    Science.gov (United States)

    Kim, W Chan; Mauborgne, Renée

    2003-04-01

    When William Bratton was appointed police commissioner of New York City in 1994, turf wars over jurisdiction and funding were rife and crime was out of control. Yet in less than two years, and without an increase in his budget, Bratton turned New York into the safest large city in the nation. And the NYPD was only the latest of five law-enforcement agencies Bratton had turned around. In each case, he succeeded in record time despite limited resources, a demotivated staff, opposition from powerful vested interests, and an organization wedded to the status quo. Bratton's turnarounds demonstrate what the authors call tipping point leadership. The theory of tipping points hinges on the insight that in any organization, fundamental changes can occur quickly when the beliefs and energies of a critical mass of people create an epidemic movement toward an idea. Bratton begins by overcoming the cognitive hurdles that block organizations from recognizing the need for change. He does this by putting managers face-to-face with operational problems. Next, he manages around limitations on funds, staff, or equipment by concentrating resources on the areas that are most in need of change and that have the biggest payoffs. He meanwhile solves the motivation problem by singling out key influencers--people with disproportionate power due to their connections or persuasive abilities. Finally, he closes off resistance from powerful opponents. Not every CEO has the personality to be a Bill Bratton, but his successes are due to much more than his personality. He relies on a remarkably consistent method that any manager looking to turn around an organization can use to overcome the forces of inertia and reach the tipping point.

  1. PowerPoint Presentation

    Indian Academy of Sciences (India)

    Table of contents. PowerPoint Presentation · Slide 2 · Slide 3 · Slide 4 · Slide 5 · Slide 6 · Slide 7 · Metal Oxides: Range of properties · Slide 9 · Slide 10 · Slide 11 · Slide 12 · Slide 13 · Slide 14 · Slide 15 · Slide 16 · Slide 17 · Slide 18 · Slide 19 · Slide 20 · Slide 21 · Slide 22 · Slide 23 · Slide 24 · Slide 25 · Slide 26 · Slide 27.

  2. PowerPoint Presentation

    Indian Academy of Sciences (India)

    PowerPoint Presentation · Slide 2 · Slide 3 · Slide 4 · Slide 5 · Slide 6 · Slide 7 · Slide 8 · Slide 9 · Slide 10 · Slide 11 · Slide 12 · 2-D Aromaticity · Condensed Aromatics and Hückel Rule · Slide 15 · Slide 16 · Slide 17 · Slide 18 · Slide 19 · Slide 20 · Slide 21 · Slide 22 · Slide 23 · Slide 24 · Slide 25 · Slide 26 · Slide 27 · Slide 28.

  3. Mise au point

    African Journals Online (AJOL)

    tomie est replacé et fixé par des fils d'acier, krönlein lais- sait ce fragment pédiculé au fascia temporalis afin d'évi- ter la dépression de la fosse temporale due à la désinser- tion du muscle temporal [20] ; dans notre série, après reconstitution du cadre, le muscle temporal est suturé à son point d'insertion. pour les tumeurs ...

  4. The point on.

    International Nuclear Information System (INIS)

    1996-01-01

    In this last article, we find the point of view about the world petroleum activity, the reserves and the recent discoveries, the deep offshore, the technological developments in petroleum upstream. The petroleum situation in China is treated. The trends of world refining are described. The recent technological developments in the petroleum downstream are detailed. The prices of crude oil and the refining margins are the subject of a chapter. The investments of hydrocarbons area are given, the world trade and the lng projects, the gas availability in Western Europe have their place. The trends of European automobile industry and the fuels distribution are also discussed. (N.C.)

  5. Torsades de Pointes

    Directory of Open Access Journals (Sweden)

    Richard J Chen, MD

    2018-04-01

    Full Text Available History of present illness: 70-year-old male with a history ventricular arrhythmia, AICD (automated implantable cardioverter defibrillator, coronary artery disease and cardiac stents presented to the Emergency Department after three AICD discharges with dyspnea but no chest pain. During triage, he was found to have an irregular radial pulse and was placed on a cardiac monitor. Significant findings: The patient was found to be in a polymorphic ventricular tachycardia; he was alert, awake and asymptomatic. A rhythm strip showed a wide complex tachycardia with the QRS complex varying in amplitude around the isoelectric line consistent with Torsades de Pointes. Discussion: Torsades de Pointes (TdP is a specific type of polymorphic ventricular tachycardia. The arrhythmia’s characteristic morphology consists of the QRS complex “twisting” around the isoelectric line with gradual variation of the amplitude, reflecting its literal translation of “twisting of the points.”1 This arrhythmia occurs in the context of prolonged QT. The most common form of acquired QT prolongation is medication induced. Common causes include antiarrhythmics, antipsychotics, antiemetics, and antibiotics.2 Patient specific risk factors include female sex, bradycardia, hypokalemia, hypomagnesemia, hypocalcemia, hypothermia and heart disease.3 In the setting of prolonged QT, the repolarization phase is extended. TdP is initiated when a PVC (premature ventricular contraction occurs during this repolarization, known as an ‘R on T’ phenomenon. TdP is often asymptomatic and self-limited. The danger in TdP is its potential to deteriorate into ventricular fibrillation. A mainstay of management of TdP is prevention of risk factors when possible.4 Unstable patients should be treated with synchronized cardioversion. Magnesium sulfate should be administered in all cases of TdP.1 If a patient is not responsive to magnesium, consider isoproterenol, amiodarone, and overdrive

  6. Transaction charges allocation using sensitivity factor methodology

    Indian Academy of Sciences (India)

    power flow due to each transaction is calculated based on a sensitivity factor called (ACPTDF) and the transmission ... basic transmission pricing methods in the deregulated power system are Postage Stamp Pric- ing Method ..... (southern major power source point) and Madurai (middle major power demand point). This is.

  7. Relative Critical Points

    Directory of Open Access Journals (Sweden)

    Debra Lewis

    2013-05-01

    Full Text Available Relative equilibria of Lagrangian and Hamiltonian systems with symmetry are critical points of appropriate scalar functions parametrized by the Lie algebra (or its dual of the symmetry group. Setting aside the structures – symplectic, Poisson, or variational – generating dynamical systems from such functions highlights the common features of their construction and analysis, and supports the construction of analogous functions in non-Hamiltonian settings. If the symmetry group is nonabelian, the functions are invariant only with respect to the isotropy subgroup of the given parameter value. Replacing the parametrized family of functions with a single function on the product manifold and extending the action using the (coadjoint action on the algebra or its dual yields a fully invariant function. An invariant map can be used to reverse the usual perspective: rather than selecting a parametrized family of functions and finding their critical points, conditions under which functions will be critical on specific orbits, typically distinguished by isotropy class, can be derived. This strategy is illustrated using several well-known mechanical systems – the Lagrange top, the double spherical pendulum, the free rigid body, and the Riemann ellipsoids – and generalizations of these systems.

  8. Referential Zero Point

    Directory of Open Access Journals (Sweden)

    Matjaž Potrč

    2016-04-01

    Full Text Available Perhaps the most important controversy in which ordinary language philosophy was involved is that of definite descriptions, presenting referential act as a community-involving communication-intention endeavor, thereby opposing the direct acquaintance-based and logical proper names inspired reference aimed at securing truth conditions of referential expression. The problem of reference is that of obtaining access to the matters in the world. This access may be forthcoming through the senses, or through descriptions. A review of how the problem of reference is handled shows though that one main practice is to indulge in relations of acquaintance supporting logical proper names, demonstratives, indexicals and causal or historical chains. This testifies that the problem of reference involves the zero point, and with it phenomenology of intentionality. Communication-intention is but one dimension of rich phenomenology that constitutes an agent’s experiential space, his experiential world. Zero point is another constitutive aspect of phenomenology involved in the referential relation. Realizing that the problem of reference is phenomenology based opens a new perspective upon the contribution of analytical philosophy in this area, reconciling it with continental approach, and demonstrating variations of the impossibility related to the real. Chromatic illumination from the cognitive background empowers the referential act, in the best tradition of ordinary language philosophy.

  9. Bright point study

    International Nuclear Information System (INIS)

    Tang, F.; Harvey, K.; Bruner, M.; Kent, B.; Antonucci, E.

    1982-01-01

    Transition region and coronal observations of bright points by instruments aboard the Solar Maximum Mission and high resolution photospheric magnetograph observations on September 11, 1980 are presented. A total of 31 bipolar ephemeral regions were found in the photosphere from birth in 9.3 hours of combined magnetograph observations from three observatories. Two of the three ephemeral regions present in the field of view of the Ultraviolet Spectrometer-Polarimeter were observed in the C IV 1548 line. The unobserved ephemeral region was determined to be the shortest-lived (2.5 hr) and lowest in magnetic flux density (13G) of the three regions. The Flat Crystal Spectrometer observed only low level signals in the O VIII 18.969 A line, which were not statistically significant to be positively identified with any of the 16 ephemeral regions detected in the photosphere. In addition, the data indicate that at any given time there lacked a one-to-one correspondence between observable bright points and photospheric ephemeral regions, while more ephemeral regions were observed than their counterparts in the transition region and the corona

  10. 76 FR 63913 - Commercial Building Workforce Job/Task Analyses

    Science.gov (United States)

    2011-10-14

    ... of persons in the commercial building space. DATES: Comments on the six Job/Task Analyses must be.../Task Analyses. 2. Support increased workforce mobility up career ladders and across career lattices by... held. To help DOE better understand at which point in the commenter's career certain skills are...

  11. Analysing Scenarios of Cell Population System Development

    Directory of Open Access Journals (Sweden)

    M. S. Vinogradova

    2014-01-01

    Full Text Available The article considers an isolated population system consisting of two types of human stem cells, namely normal cells and cells with chromosomal abnormalities (abnormal ones. The system develops in the laboratory (in vitro. The article analyses possible scenarios of the population system development, which are implemented for different values of its parameters. An investigated model of the cell population system takes into account the limited resources. It is represented as a system of two nonlinear differential equations with continuous right-hand part. The model is considered with non-negative values of the variables; the domain is divided into four sets. The model feature is that in each set the right part of the system of differential equations has a different form.The article analyses a quality of the rest points of the system in each of four sets. The analytical conditions for determination of the number of rest points and the quality of rest points, with, at least, one zero coordinate, are obtained.It is shown that the population system under study cannot have more than two points of rest, both coordinates of which are positive (non-zero. It is difficult to determine quality of such rest points depending on the model parameters due to the complexity of the expressions, which define the systems of the first approximation, recorded in a neighborhood of these points of rest. Numerical research results of the stability of these points of rest are obtained, and phase portraits with the specified specific values of the system parameters are demonstrated. The main scenarios for the cell population development are adduced. Analysis of mathematical model shows that a cell population system may remain the system consisting of populations of normal and abnormal cells; it can degenerate into a population of abnormal cells or perish. The scenario, in which there is only the population of normal cells, is not implemented. The numerical simulation

  12. The Point Mass Concept

    Directory of Open Access Journals (Sweden)

    Lehnert B.

    2011-04-01

    Full Text Available A point-mass concept has been elaborated from the equations of the gravitational field. One application of these deductions results in a black hole configuration of the Schwarzschild type, having no electric charge and no angular momentum. The critical mass of a gravitational collapse with respect to the nuclear binding energy is found to be in the range of 0.4 to 90 solar masses. A second application is connected with the spec- ulation about an extended symmetric law of gravitation, based on the options of positive and negative mass for a particle at given positive energy. This would make masses of equal polarity attract each other, while masses of opposite polarity repel each other. Matter and antimatter are further proposed to be associated with the states of positive and negative mass. Under fully symmetric conditions this could provide a mechanism for the separation of antimatter from matter at an early stage of the universe.

  13. Critical Points of Contact

    DEFF Research Database (Denmark)

    Jensen, Ole B.; Morelli, Nicola

    2011-01-01

    In contemporary urban societies multiple networks and systems interact, overlap, exist in parallel, converge, conflict etc. creating unforeseen complexity and less transparency. By exploring how layered networks of physical movement, service information, goods delivery, commercial communication etc....... are connected (and disconnected) we get a much better understanding of how to design and intervene regardless if we are thinking about public spaces in the city or new systems of service design. The many networks orchestrating and facilitating contemporary everyday life are dependent on the strategic sites...... where the networks meet and establish contact. Thus we argue for the usefulness of the notion of Critical Point of Contact (CPC) to deepen our understanding of the actual life within networks. En route to this notion we draw upon theories within as diverse realms such as interaction design, service...

  14. Point Pollution Sources Dimensioning

    Directory of Open Access Journals (Sweden)

    Georgeta CUCULEANU

    2011-06-01

    Full Text Available In this paper a method for determining the main physical characteristics of the point pollution sources is presented. It can be used to find the main physical characteristics of them. The main physical characteristics of these sources are top inside source diameter and physical height. The top inside source diameter is calculated from gas flow-rate. For reckoning the physical height of the source one takes into account the relation given by the proportionality factor, defined as ratio between the plume rise and physical height of the source. The plume rise depends on the gas exit velocity and gas temperature. That relation is necessary for diminishing the environmental pollution when the production capacity of the plant varies, in comparison with the nominal one.

  15. The Point Mass Concept

    Directory of Open Access Journals (Sweden)

    Lehnert B.

    2011-04-01

    Full Text Available A point-mass concept has been elaborated from the equations of the gravitational field. One application of these deductions results in a black hole configuration of the Schwarzschild type, having no electric charge and no angular momentum. The critical mass of a gravitational collapse with respect to the nuclear binding energy is found to be in the range of 0.4 to 90 solar masses. A second application is connected with the speculation about an extended symmetric law of gravitation, based on the options of positive and negative mass for a particle at given positive energy. This would make masses of equal polarity attract each other, while masses of opposite polarity repel each other. Matter and antimatter are further proposed to be associated with the states of positive and negative mass. Under fully symmetric conditions this could provide a mechanism for the separation of antimatter from matter at an early stage of the universe.

  16. Critical Points of Contact

    DEFF Research Database (Denmark)

    Jensen, Ole B.; Wind, Simon; Lanng, Ditte Bendix

    2012-01-01

    student studios made at the 1st semester of the Urban Design Master Programme in the fall of 2009 and 2010. The CPC concept is double edged since it both provides the stepping-stone for analysis as well as scaffolding for intervention and re-design. Thereby, it fits the underlying philosophy of teaching......In this brief article, we shall illustrate the application of the analytical and interventionist concept of ‘Critical Points of Contact’ (CPC) through a number of urban design studios. The notion of CPC has been developed over a span of the last three to four years and is reported in more detail...... elsewhere (Jensen & Morelli 2011). In this article, we will only discuss the conceptual and theoretical framing superficially, since our real interest is to show and discuss the concept's application value to spatial design in a number of urban design studios. The 'data' or the projects presented are seven...

  17. Properties of residuals for spatial point processes

    DEFF Research Database (Denmark)

    Baddeley, A.; Møller, Jesper; Pakes, A. G.

    2008-01-01

    For any point process in Rd that has a Papangelou conditional intensity λ, we define a random measure of ‘innovations' which has mean zero. When the point process model parameters are estimated from data, there is an analogous random measure of ‘residuals'. We analyse properties of the innovation...... and residuals, including first and second moments, conditional independence, a martingale property, and lack of correlation. Some large sample asymptotics are studied. We derive the marginal distribution of smoothed residuals by solving a distributional equivalence....

  18. Proposal of cutoff points for pediatric daytime sleepiness scale to identify excessive daytime sleepiness.

    Science.gov (United States)

    Meyer, Carolina; Barbosa, Diego Grasel; Junior, Geraldo Jose Ferrari; Andrade, Rubian Diego; Silva, Diego Augusto Santos; Pelegrini, Andreia; Gomes Felden, Érico Pereira

    2018-03-01

    The objective of the present study was to propose cutoff points for the Pediatric Daytime Sleepiness Scale (PDSS) through sensitivity and specificity analyses in order to identify excessive daytime sleepiness, considering parameters such as duration and quality of sleep, health perception, stress control and depressive moods (feelings of sadness) in adolescents. A total of 1,132 adolescents, aged 14-19 years old, of both sexes, from the public high school of São José - SC, answered the questionnaire with information on age, daytime sleepiness, sleep duration, health perception, stress management, depressive moods (feelings of sadness) and quality of sleep. The Receiver Operating Characteristic (ROC) curve was used to estimate cutoff points considering the sensitivity and specificity values ​​that best identify adolescents with excessive daytime sleepiness, using independent variables as a reference. The majority of the sample was female (54.2%), aged 14-16 years. The girls presented worse quality of sleep (66.4%), and the boys had a more positive perception of health (74.8%), better stress control (64.8%) and lower depressive moods (feelings of sadness) (63.3%). The largest area in the ROC curve was the one that considered sleep quality as a parameter in both sexes (area of the curve = 0.709 and 0.659, respectively, for boys and girls, p sleep quality as a reference, the cutoff point for excessive daytime sleepiness was 15 points. The other parameters used were also significant (p sleep quality was the parameter most strongly related to daytime sleepiness, and a cutoff of 15 points for the PDSS for both sexes should be used in the definition of excessive daytime sleepiness. For the other parameters, stress management, depressive mood (feelings of sadness) and health perception, different cutoff points are suggested for boys and girls.

  19. Cloud-point extraction and spectrophotometric determination of ...

    African Journals Online (AJOL)

    Aneco-friendly, simple and very sensitive method was developed for preconcentration and determination of clonazepam (CLO) in pharmaceutical dosage forms using cloud point extraction (CPE) technique. The method is based on cloud point extraction of product from oxidative coupling between reduced CLO and ...

  20. Relationships between melting point and boiling point of organic compounds

    Energy Technology Data Exchange (ETDEWEB)

    Yalkowsky, S.H.; Krzyzaniak, J.F.; Myrdal, P.B. (Univ. of Arizona, Tucson, AZ (United States). College of Pharmacy)

    1994-07-01

    Relationships between melting point and boiling point are shown to be dependent upon the molecular symmetry number and a modified count of the total number of atoms in the molecule. Using the above relationships, the boiling and melting points of nearly 1,000 non-hydrogen-bonding organic compounds have been correlated. The correlations for boiling point and melting point have root mean square errors of 28 and 36 C, respectively.

  1. May 2002 Lidar Point Data of Southern California Coastline: Dana Point to Point La Jolla

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains lidar point data from a strip of Southern California coastline (including water, beach, cliffs, and top of cliffs) from Dana Point to Point La...

  2. September 2002 Lidar Point Data of Southern California Coastline: Dana Point to Point La Jolla

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains lidar point data from a strip of Southern California coastline (including water, beach, cliffs, and top of cliffs) from Dana Point to Point La...

  3. Infrared point sensors for homeland defense applications

    Science.gov (United States)

    Thomas, Ross C.; Carter, Michael T.; Homrighausen, Craig L.

    2004-03-01

    We report recent progress toward the development of infrared point sensors for the detection of chemical warfare agents and explosive related chemicals, which pose a significant threat to both health and environment. Technical objectives have focused on the development of polymer sorbents to enhance the infrared response of these hazardous organic compounds. For example, infrared point sensors which part-per-billion detection limits have been developed that rapidlypartition chemical warfare agents and explosive related chemicals into polymer thin films with desirable chemical and physical properties. These chemical sensors demonstrate novel routes to reversible sensing of hazardous organic compounds. The development of small, low-power, sensitive, and selective instruments employing these chemical sensors would enhance the capabilities of federal, state, and local emergency response to incidents involving chemical terrorism. Specific applications include chemical defense systems for military personnel and homeland defense, environmental monitors for remediation and demilitarization, and point source detectors for emergency and maintenance response teams.

  4. Sensitivity analysis of EQ3

    International Nuclear Information System (INIS)

    Horwedel, J.E.; Wright, R.Q.; Maerker, R.E.

    1990-01-01

    A sensitivity analysis of EQ3, a computer code which has been proposed to be used as one link in the overall performance assessment of a national high-level waste repository, has been performed. EQ3 is a geochemical modeling code used to calculate the speciation of a water and its saturation state with respect to mineral phases. The model chosen for the sensitivity analysis is one which is used as a test problem in the documentation of the EQ3 code. Sensitivities are calculated using both the CHAIN and ADGEN options of the GRESS code compiled under G-float FORTRAN on the VAX/VMS and verified by perturbation runs. The analyses were performed with a preliminary Version 1.0 of GRESS which contains several new algorithms that significantly improve the application of ADGEN. Use of ADGEN automates the implementation of the well-known adjoint technique for the efficient calculation of sensitivities of a given response to all the input data. Application of ADGEN to EQ3 results in the calculation of sensitivities of a particular response to 31,000 input parameters in a run time of only 27 times that of the original model. Moreover, calculation of the sensitivities for each additional response increases this factor by only 2.5 percent. This compares very favorably with a running-time factor of 31,000 if direct perturbation runs were used instead. 6 refs., 8 tabs

  5. CADDIS Volume 4. Data Analysis: Advanced Analyses - Controlling for Natural Variability: SSD Plot Diagrams

    Science.gov (United States)

    Methods for controlling natural variability, predicting environmental conditions from biological observations method, biological trait data, species sensitivity distributions, propensity scores, Advanced Analyses of Data Analysis references.

  6. Function Point Analysis Depot

    Science.gov (United States)

    Muniz, R.; Martinez, El; Szafran, J.; Dalton, A.

    2011-01-01

    The Function Point Analysis (FPA) Depot is a web application originally designed by one of the NE-C3 branch's engineers, Jamie Szafran, and created specifically for the Software Development team of the Launch Control Systems (LCS) project. The application consists of evaluating the work of each developer to be able to get a real estimate of the hours that is going to be assigned to a specific task of development. The Architect Team had made design change requests for the depot to change the schema of the application's information; that information, changed in the database, needed to be changed in the graphical user interface (GUI) (written in Ruby on Rails (RoR and the web service/server side in Java to match the database changes. These changes were made by two interns from NE-C, Ricardo Muniz from NE-C3, who made all the schema changes for the GUI in RoR and Edwin Martinez, from NE-C2, who made all the changes in the Java side.

  7. Five points on columns

    Directory of Open Access Journals (Sweden)

    Kathleen S Rockland

    2010-06-01

    Full Text Available Abstract “Column,” like “gene,” has both conceptual and linguistic shortcomings. The simple question “what is a column” is not easy to answer and the word itself is not easy to replace. In the present article, I have selected five points, in no way comprehensive or canonical, but which may nevertheless serve as a prompt and aid for further discussions and reevaluation. These are: that anatomical columns are not solid structures, that they are part of locally interdigitating systems, that any delimited column also participates in a widely distributed network, that columns are not an obligatory cortical feature, and that columns (as “modules” occur widely in the brain in non-cortical structures. I focus on the larger scale macrocolumns, mainly from an anatomical perspective. My position is that cortical organization is inherently dynamic and likely to incorporate multiple processing styles. One can speculate that the distributed mappings within areas like piriform cortex may resemble at least one mode of neocortical processing strategy.

  8. ATLAS Point 1 Construction

    CERN Multimedia

    Inigo-Golfin, J

    After 3 years of work in point 1, a number of surface buildings have already been completed and handed over to CERN (the control, the gas and the cooling and ventilation buildings) and, probably more appealing to the public, 60,000 m3 of earth have already been excavated from underground. At present, the technical cavern USA15 and its access shaft are almost finished, leaving only the main cavern and the liaison galleries to be completed in the coming year and a half. The main cavern has been excavated down to the radiation limit and its walls and vault will presently be concreted (see below the picture of the section of the vault with the impressive shell of 1.2 m thickness). The excavation of the bench (27 vertical metres to go yet!) will proceed from August, when some additional civil engineering work in the LHC tunnel will be undertaken. Needless to say many different services are necessary around the detector, both for its installation and future operation for physics. To that end much of the heavy...

  9. Point 1 Updates

    CERN Multimedia

    Inigo-Golfin, J.

    The ATLAS experimental area is located in Point 1, just across the main CERN entrance, in the commune of Meyrin. There people are ever so busy to finish the different infrastructures for ATLAS. Not only has Civil Engineering finished the construction of the USA15 technical cavern, but the excavation of the main UX15 cavern has resumed below the machine tunnel, after a brief halt to allow the construction of the UJ-caverns for the power converters of the LHC machine. The excavation work should end in August 2002. The UX15 hand-over to ATLAS is expected in April 2003. On the surface civil engineering is starting to complete the last two surface buildings (SDX1 and SH1), once the services (cooling pipes, ventilation ducts and the largest item, the lift modules and its lift of course) in the shaft PX15 have been completed. But the civil engineering is not all. A lot more is under way. The site installation of the steel structures in the caverns is to begin in Autumn, along with all the cooling pipes, airconditi...

  10. Rational points on varieties

    CERN Document Server

    Poonen, Bjorn

    2017-01-01

    This book is motivated by the problem of determining the set of rational points on a variety, but its true goal is to equip readers with a broad range of tools essential for current research in algebraic geometry and number theory. The book is unconventional in that it provides concise accounts of many topics instead of a comprehensive account of just one-this is intentionally designed to bring readers up to speed rapidly. Among the topics included are Brauer groups, faithfully flat descent, algebraic groups, torsors, étale and fppf cohomology, the Weil conjectures, and the Brauer-Manin and descent obstructions. A final chapter applies all these to study the arithmetic of surfaces. The down-to-earth explanations and the over 100 exercises make the book suitable for use as a graduate-level textbook, but even experts will appreciate having a single source covering many aspects of geometry over an unrestricted ground field and containing some material that cannot be found elsewhere. The origins of arithmetic (o...

  11. "Point de suspension"

    CERN Document Server

    2004-01-01

    CERN - Globe of Science and Innovation 20 and 21 October Acrobatics, mime, a cappella singing, projections of images, a magical setting... a host of different tools of a grandeur matching that of the Universe they relate. A camera makes a massive zoom out to reveal the multiple dimensions of Nature. Freeze the frame: half way between the infinitesimally small and the infinitesimally large, a man suspends his everyday life (hence the title "Point de Suspension", which refers to the three dots at the end of an uncompleted sentence) to take a glimpse of the place he occupies in the great history of the Universe. An unusual perspective on what it means to be a human being... This wondrous show in the Globe of Science and Innovation, specially created by the Miméscope* company for the official ceremony marking CERN's fiftieth anniversary, is a gift from the Government of the Republic and Canton of Geneva, which also wishes to share this moment of wonder with the local population. There will be three perfo...

  12. "Point de suspension"

    CERN Multimedia

    2004-01-01

    http://www.cern.ch/cern50/ CERN - Globe of Science and Innovation 20 and 21 October Acrobatics, mime, a cappella singing, projections of images, a magical setting... a host of different tools of a grandeur matching that of the Universe they relate. A camera makes a massive zoom out to reveal the multiple dimensions of Nature. Freeze the frame: half way between the infinitesimally small and the infinitesimally large, a man suspends his everyday life (hence the title "Point de Suspension", which refers to the three dots at the end of an uncompleted sentence) to take a glimpse of the place he occupies in the great history of the Universe. An unusual perspective on what it means to be a human being... This wondrous show in the Globe of Science and Innovation, specially created by the Miméscope* company for the official ceremony marking CERN's fiftieth anniversary, is a gift from the Government of the Republic and Canton of Geneva, which also wishes to share this moment of wonder with the local pop...

  13. "Point de suspension"

    CERN Document Server

    2004-01-01

    CERN - Globe of Science and Innovation 20 and 21 October Acrobatics, mime, a cappella singing, projections of images, a magical setting... a host of different tools of a grandeur matching that of the Universe they relate. A camera makes a massive zoom out to reveal the multiple dimensions of Nature. Freeze the frame: half way between the infinitesimally small and the infinitesimally large, a man suspends his everyday life (hence the title "Point de Suspension", which refers to the three dots at the end of an uncompleted sentence) to take a glimpse of the place he occupies in the great history of the Universe. An unusual perspective on what it means to be a human being... This spectacle in the Globe of Science and Innovation, specially created by the Miméscope* company for the official ceremony marking CERN's fiftieth anniversary, is a gift from the Government of the Republic and Canton of Geneva, which also wishes to share this moment of wonder with the local population. There will be three performances for...

  14. The Tipping Points of Technology Development

    Directory of Open Access Journals (Sweden)

    Tauno Kekäle

    2014-07-01

    Full Text Available The tipping point, the decisive point in time in the competition between old and new, is an interesting phenomenon in physics of today. This aspect in technology acceptance is connected to many business decisions such as technology investments, product releases, resource allocation, sales forecasts and, ultimately, affects the profitability and even survival of a company. The tipping point itself is based on many stochastic and dynamic variables, and the process may at least partly be described as path-dependent. This paper analyses the tipping point from three aspects: (1 product performance, (2 features of the market and infrastructure (including related technologies and human network externalities, and (3 actions of the incumbents (including customer lock-in, systems lock-in, and sustaining innovation. The paper is based on the Bass s-curve idea and the technology trajectory concept proposed by Dosi. Three illustrative cases are presented to make the point of the multiple factors affecting technology acceptance and, thus, the tipping point. The paper also suggests outlines for further research in field of computer simulation.

  15. Pratique de l'analyse fonctionelle

    CERN Document Server

    Tassinari, Robert

    1997-01-01

    Mettre au point un produit ou un service qui soit parfaitement adapté aux besoins et aux exigences du client est indispensable pour l'entreprise. Pour ne rien laisser au hasard, il s'agit de suivre une méthodologie rigoureuse : celle de l'analyse fonctionnelle. Cet ouvrage définit précisément cette méthode ainsi que ses champs d'application. Il décrit les méthodes les plus performantes en termes de conception de produit et de recherche de qualité et introduit la notion d'analyse fonctionnelle interne. Un ouvrage clé pour optimiser les processus de conception de produit dans son entreprise. -- Idées clés, par Business Digest

  16. Cost/benefit analyses of environmental impact

    International Nuclear Information System (INIS)

    Goldman, M.I.

    1974-01-01

    Various aspects of cost-benefit analyses are considered. Some topics discussed are: regulations of the National Environmental Policy Act (NEPA); statement of AEC policy and procedures for implementation of NEPA; Calvert Cliffs decision; AEC Regulatory Guide; application of risk-benefit analysis to nuclear power; application of the as low as practicable (ALAP) rule to radiation discharges; thermal discharge restrictions proposed by EPA under the 1972 Amendment to the Water Pollution Control Act; estimates of somatic and genetic insult per unit population exposure; occupational exposure; EPA Point Source Guidelines for Discharges from Steam Electric Power Plants; and costs of closed-cycle cooling using cooling towers. (U.S.)

  17. PynPoint code for exoplanet imaging

    Science.gov (United States)

    Amara, A.; Quanz, S. P.; Akeret, J.

    2015-04-01

    We announce the public release of PynPoint, a Python package that we have developed for analysing exoplanet data taken with the angular differential imaging observing technique. In particular, PynPoint is designed to model the point spread function of the central star and to subtract its flux contribution to reveal nearby faint companion planets. The current version of the package does this correction by using a principal component analysis method to build a basis set for modelling the point spread function of the observations. We demonstrate the performance of the package by reanalysing publicly available data on the exoplanet β Pictoris b, which consists of close to 24,000 individual image frames. We show that PynPoint is able to analyse this typical data in roughly 1.5 min on a Mac Pro, when the number of images is reduced by co-adding in sets of 5. The main computational work, the calculation of the Singular-Value-Decomposition, parallelises well as a result of a reliance on the SciPy and NumPy packages. For this calculation the peak memory load is 6 GB, which can be run comfortably on most workstations. A simpler calculation, by co-adding over 50, takes 3 s with a peak memory usage of 600 MB. This can be performed easily on a laptop. In developing the package we have modularised the code so that we will be able to extend functionality in future releases, through the inclusion of more modules, without it affecting the users application programming interface. We distribute the PynPoint package under GPLv3 licence through the central PyPI server, and the documentation is available online (http://pynpoint.ethz.ch).

  18. Multiple Imputation for Network Analyses

    NARCIS (Netherlands)

    Krause, Robert; Huisman, Mark; Steglich, Christian; Snijders, Thomas

    2016-01-01

    Missing data on network ties is a fundamental problem for network analyses. The biases induced by missing edge data, even when missing completely at random (MCAR), are widely acknowledged and problematic for network analyses (Kossinets, 2006; Huisman & Steglich, 2008; Huisman, 2009). Although

  19. Exploring Foundation Concepts in Introductory Statistics Using Dynamic Data Points

    Science.gov (United States)

    Ekol, George

    2015-01-01

    This paper analyses introductory statistics students' verbal and gestural expressions as they interacted with a dynamic sketch (DS) designed using "Sketchpad" software. The DS involved numeric data points built on the number line whose values changed as the points were dragged along the number line. The study is framed on aggregate…

  20. The computed cranial focal point

    NARCIS (Netherlands)

    Jong, G.A. de; Maal, T.J.J.; Delye, H.

    2015-01-01

    INTRODUCTION: Stereophotogrammetry is a radiation-free method for monitoring skull development after craniosynostosis repair. Lack of clear fixed reference points complicate longitudinal comparison of 3D photographs. Therefore we developed the 'computed cranial focal point' (CCFP). METHODS: The CCFP

  1. Hazards And Critical Control Points Of Yoghurt Produced In A ...

    African Journals Online (AJOL)

    Hazard analyses of yoghurt, produced by the Dairy Unit of a Research Institute farm in Zaria were conducted to determine hazards associated with the processing of milk supplied to the unit into the milk product, and also to determine critical control points that are necessary for effective control of the hazards. The analyses ...

  2. EULAR points to consider when establishing, analysing and reporting safety data of biologics registers in rheumatology

    DEFF Research Database (Denmark)

    Dixon, William G; Carmona, Loreto; Finckh, Axel

    2010-01-01

    The introduction of biological therapies for the treatment of rheumatic diseases has drawn attention to the limitations of traditional means of assessing drug safety. Consequently, a series of European academic biologics registers dedicated to this task have been established. Increasing reliance...

  3. Statistical improvements in functional magnetic resonance imaging analyses produced by censoring high-motion data points.

    Science.gov (United States)

    Siegel, Joshua S; Power, Jonathan D; Dubis, Joseph W; Vogel, Alecia C; Church, Jessica A; Schlaggar, Bradley L; Petersen, Steven E

    2014-05-01

    Subject motion degrades the quality of task functional magnetic resonance imaging (fMRI) data. Here, we test two classes of methods to counteract the effects of motion in task fMRI data: (1) a variety of motion regressions and (2) motion censoring ("motion scrubbing"). In motion regression, various regressors based on realignment estimates were included as nuisance regressors in general linear model (GLM) estimation. In motion censoring, volumes in which head motion exceeded a threshold were withheld from GLM estimation. The effects of each method were explored in several task fMRI data sets and compared using indicators of data quality and signal-to-noise ratio. Motion censoring decreased variance in parameter estimates within- and across-subjects, reduced residual error in GLM estimation, and increased the magnitude of statistical effects. Motion censoring performed better than all forms of motion regression and also performed well across a variety of parameter spaces, in GLMs with assumed or unassumed response shapes. We conclude that motion censoring improves the quality of task fMRI data and can be a valuable processing step in studies involving populations with even mild amounts of head movement. Copyright © 2013 Wiley Periodicals, Inc.

  4. Developments in Kosovo’s economy analysed on a macroeconomic point of view

    Directory of Open Access Journals (Sweden)

    Dr.Sc. Myrvete Badivuku - Pantina

    2011-12-01

    Full Text Available Despite that in the last years, Kosovo has experienced economic growth, it still remains the least developed country in Europe. Kosovo’s economy is still fragile. During 2009 Kosovo’s economy peaked at 4.0% while during 2010, economic growth achieved 4.6%, while the GDP was estimated to be 4.2 Billion Euros. During 2009, Kosovo’s economy was characterised by deflation (-2.4%, during 2010 it saw a raise in inflation, while consumer price index was rated at 3.5%. There is still a high rate of unemployment in the labour market, about 45%, and it remains a challenge for the country’s economy. During 2009, money deposited from Kosovars living abroad experienced a decline of 5.6%, where during 2010 these deposits marked a slight improvement. Trading imbalances since the post-war period have continued in 2010, which has created a high level of dependence of commercial deficit (deficit constitutes about 45% of the GDP. The purpose of this study is to give a clear view of the macroeconomic situation of Kosovo through a comprehensive analysis and critical approach towards developments so far, in order to improve the economic state in the future.

  5. Analysing the distribution of synaptic vesicles using a spatial point process model

    DEFF Research Database (Denmark)

    Khanmohammadi, Mahdieh; Waagepetersen, Rasmus; Nava, Nicoletta

    2014-01-01

    Stress can affect the brain functionality in many ways. As the synaptic vesicles have a major role in nervous signal transportation in synapses, their distribution in relationship to the active zone is very important in studying the neuron responses. We study the effect of stress on brain functio...

  6. Stress sensitivity in psychopathology: mechanisms and consequences.

    Science.gov (United States)

    Hammen, Constance

    2015-02-01

    The special section on "Stress Sensitivity in Psychopathology: Mechanisms and Consequences" presents an array of articles and results across samples of children, adolescents, and adults that are at once exciting for the field and challenging. The articles highlight an empirically and conceptually important topic in psychopathology- the role of stress. For many years, this topic was mainly a focus of depression research but has now widened to include relevance to a variety of forms of psychological disorders, as shown in this special section. In addition to the applications to many different disorders, our field of psychopathology is enriched by highlighting the remarkable range of naturalistic and experimental paradigms for studying stress processes in humans, and to learn about diverse conceptual models. The authors of the articles in this special section have given us much food for thought in their innovative studies, and their work provides fruitful guides for next steps. It is to be hoped that such work points to future integrative and collaborative studies, across levels of analyses, methods, and samples that will further elaborate on the associations between stress and psychopathology, as well as the mechanisms that have relevance to the advancement of knowledge of disorders and their treatment. (PsycINFO Database Record (c) 2015 APA, all rights reserved).

  7. Magic Pointing for Eyewear Computers

    DEFF Research Database (Denmark)

    Jalaliniya, Shahram; Mardanbegi, Diako; Pederson, Thomas

    2015-01-01

    In this paper, we propose a combination of head and eye movements for touchlessly controlling the "mouse pointer" on eyewear devices, exploiting the speed of eye pointing and accuracy of head pointing. The method is a wearable computer-targeted variation of the original MAGIC pointing approach...

  8. Noise sensitivity and reactions to noise and other environmental conditions

    NARCIS (Netherlands)

    Miedema, H.M.E.; Vos, H.

    2003-01-01

    This article integrates findings from the literature and new results regarding noise sensitivity. The new results are based on analyses of 28 combined datasets (N=23 038), and separate analyses of a large aircraft noise study (N=10939). Three topics regarding noise sensitivity are discussed, namely,

  9. Risk factors associated with sensitization to hydroxyisohexyl 3-cyclohexene carboxaldehyde.

    Science.gov (United States)

    Uter, Wolfgang; Geier, Johannes; Schnuch, Axel; Gefeller, Olaf

    2013-08-01

    Hydroxyisohexyl 3-cyclohexene carboxaldehyde (HICC) is a synthetic fragrance chemical and an important contact allergen, at least in Europe. Despite this importance, little is known about risk factors associated with this allergen. To examine factors from the history and clinical presentation of patch tested patients associated with HICC sensitization. Contact allergy surveillance data of 95 637 patients collected by the Information Network of Departments of Dermatology (IVDK, www.ivkd.org) in 2002-2011 were analysed. Point and interval estimates of the relative risk were derived from multifactorial logistic regression modelling. The overall prevalence of HICC sensitization was 2.24%. The strongest risk factors were polysensitization and dermatitis of the axillae, followed by dermatitis at other sites. No consistent and significant time trend was observed in this analysis. As compared with the youngest patients, the odds of HICC sensitization increased approximately three-fold in the 52-67-year age group, and strongly declined with further increasing age. The risk pattern with regard to age and affected anatomical site differed from that observed with other fragrance screening allergens. Cosmetic exposure, as broadly defined here, was a stronger and more prevalent individual risk factor than occupational exposure. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  10. Sensitivity Analysis of Multidisciplinary Rotorcraft Simulations

    Science.gov (United States)

    Wang, Li; Diskin, Boris; Biedron, Robert T.; Nielsen, Eric J.; Bauchau, Olivier A.

    2017-01-01

    A multidisciplinary sensitivity analysis of rotorcraft simulations involving tightly coupled high-fidelity computational fluid dynamics and comprehensive analysis solvers is presented and evaluated. An unstructured sensitivity-enabled Navier-Stokes solver, FUN3D, and a nonlinear flexible multibody dynamics solver, DYMORE, are coupled to predict the aerodynamic loads and structural responses of helicopter rotor blades. A discretely-consistent adjoint-based sensitivity analysis available in FUN3D provides sensitivities arising from unsteady turbulent flows and unstructured dynamic overset meshes, while a complex-variable approach is used to compute DYMORE structural sensitivities with respect to aerodynamic loads. The multidisciplinary sensitivity analysis is conducted through integrating the sensitivity components from each discipline of the coupled system. Numerical results verify accuracy of the FUN3D/DYMORE system by conducting simulations for a benchmark rotorcraft test model and comparing solutions with established analyses and experimental data. Complex-variable implementation of sensitivity analysis of DYMORE and the coupled FUN3D/DYMORE system is verified by comparing with real-valued analysis and sensitivities. Correctness of adjoint formulations for FUN3D/DYMORE interfaces is verified by comparing adjoint-based and complex-variable sensitivities. Finally, sensitivities of the lift and drag functions obtained by complex-variable FUN3D/DYMORE simulations are compared with sensitivities computed by the multidisciplinary sensitivity analysis, which couples adjoint-based flow and grid sensitivities of FUN3D and FUN3D/DYMORE interfaces with complex-variable sensitivities of DYMORE structural responses.

  11. Imaging study on acupuncture points

    Energy Technology Data Exchange (ETDEWEB)

    Yan, X H; Zhang, X Y [Synchrotron Radiation Research Center, Physics Department, and Surface Physics Laboratory (State Key Laboratory) of Fudan University, Shanghai 200433 (China); Liu, C L [Physics Department of Yancheng Teachers College, Yancheng 224002 (China); Dang, R S [Second Military Medical University, Shanghai 200433 (China); Ando, M [DDS center, Research Institute for Science and Technology, Tokyo University of Science, Yamasaki 2541, Noda, Chiba 278-8510 (Japan); Sugiyama, H [Photon Factory, Institute of Material Structure Science, High Energy Accelerator Research Organization, Oho 1-1, Tsukuba, Ibaraki 305-0801 (Japan); Chen, H S [Institute of Modern Physics, Fudan University, Shanghai 200433 (China); Ding, G H, E-mail: xy-zhang@fudan.edu.c [Shanghai Research Center of Acupuncture and Meridian, Shanghai 201203 (China)

    2009-09-01

    The topographic structures of acupuncture points were investigated by using the synchrotron radiation based Dark Field Image (DFI) method. Four following acupuncture points were studied: Sanyinjiao, Neiguan, Zusanli and Tianshu. We have found that at acupuncture point regions there exists the accumulation of micro-vessels. The images taken in the surrounding tissue out of the acupuncture points do not show such kind of structure. It is the first time to reveal directly the specific structure of acupuncture points by X-ray imaging.

  12. Imaging study on acupuncture points

    International Nuclear Information System (INIS)

    Yan, X H; Zhang, X Y; Liu, C L; Dang, R S; Ando, M; Sugiyama, H; Chen, H S; Ding, G H

    2009-01-01

    The topographic structures of acupuncture points were investigated by using the synchrotron radiation based Dark Field Image (DFI) method. Four following acupuncture points were studied: Sanyinjiao, Neiguan, Zusanli and Tianshu. We have found that at acupuncture point regions there exists the accumulation of micro-vessels. The images taken in the surrounding tissue out of the acupuncture points do not show such kind of structure. It is the first time to reveal directly the specific structure of acupuncture points by X-ray imaging.

  13. PowerPoint 2010 Bible

    CERN Document Server

    Wempen, Faithe

    2010-01-01

    Master PowerPoint and improve your presentation skills-with one book!. It's no longer enough to have slide after slide of text, bullets, and charts. It's not even enough to have good speaking skills if your PowerPoint slides bore your audience. Get the very most out of all that PowerPoint 2010 has to offer while also learning priceless tips and techniques for making good presentations in this new PowerPoint 2010 Bible. Well-known PowerPoint expert and author Faithe Wempen provides formatting tips; shows you how to work with drawings, tables, and SmartArt; introduces new collaboration tools; wa

  14. TEMAC, Top Event Sensitivity Analysis

    International Nuclear Information System (INIS)

    Iman, R.L.; Shortencarier, M.J.

    1988-01-01

    1 - Description of program or function: TEMAC is designed to permit the user to easily estimate risk and to perform sensitivity and uncertainty analyses with a Boolean expression such as produced by the SETS computer program. SETS produces a mathematical representation of a fault tree used to model system unavailability. In the terminology of the TEMAC program, such a mathematical representation is referred to as a top event. The analysis of risk involves the estimation of the magnitude of risk, the sensitivity of risk estimates to base event probabilities and initiating event frequencies, and the quantification of the uncertainty in the risk estimates. 2 - Method of solution: Sensitivity and uncertainty analyses associated with top events involve mathematical operations on the corresponding Boolean expression for the top event, as well as repeated evaluations of the top event in a Monte Carlo fashion. TEMAC employs a general matrix approach which provides a convenient general form for Boolean expressions, is computationally efficient, and allows large problems to be analyzed. 3 - Restrictions on the complexity of the problem - Maxima of: 4000 cut sets, 500 events, 500 values in a Monte Carlo sample, 16 characters in an event name. These restrictions are implemented through the FORTRAN 77 PARAMATER statement

  15. Evaluating Google, Twitter, and Wikipedia as Tools for Influenza Surveillance Using Bayesian Change Point Analysis: A Comparative Analysis.

    Science.gov (United States)

    Sharpe, J Danielle; Hopkins, Richard S; Cook, Robert L; Striley, Catherine W

    2016-10-20

    Traditional influenza surveillance relies on influenza-like illness (ILI) syndrome that is reported by health care providers. It primarily captures individuals who seek medical care and misses those who do not. Recently, Web-based data sources have been studied for application to public health surveillance, as there is a growing number of people who search, post, and tweet about their illnesses before seeking medical care. Existing research has shown some promise of using data from Google, Twitter, and Wikipedia to complement traditional surveillance for ILI. However, past studies have evaluated these Web-based sources individually or dually without comparing all 3 of them, and it would be beneficial to know which of the Web-based sources performs best in order to be considered to complement traditional methods. The objective of this study is to comparatively analyze Google, Twitter, and Wikipedia by examining which best corresponds with Centers for Disease Control and Prevention (CDC) ILI data. It was hypothesized that Wikipedia will best correspond with CDC ILI data as previous research found it to be least influenced by high media coverage in comparison with Google and Twitter. Publicly available, deidentified data were collected from the CDC, Google Flu Trends, HealthTweets, and Wikipedia for the 2012-2015 influenza seasons. Bayesian change point analysis was used to detect seasonal changes, or change points, in each of the data sources. Change points in Google, Twitter, and Wikipedia that occurred during the exact week, 1 preceding week, or 1 week after the CDC's change points were compared with the CDC data as the gold standard. All analyses were conducted using the R package "bcp" version 4.0.0 in RStudio version 0.99.484 (RStudio Inc). In addition, sensitivity and positive predictive values (PPV) were calculated for Google, Twitter, and Wikipedia. During the 2012-2015 influenza seasons, a high sensitivity of 92% was found for Google, whereas the PPV for

  16. Chemical kinetic functional sensitivity analysis: Elementary sensitivities

    International Nuclear Information System (INIS)

    Demiralp, M.; Rabitz, H.

    1981-01-01

    Sensitivity analysis is considered for kinetics problems defined in the space--time domain. This extends an earlier temporal Green's function method to handle calculations of elementary functional sensitivities deltau/sub i//deltaα/sub j/ where u/sub i/ is the ith species concentration and α/sub j/ is the jth system parameter. The system parameters include rate constants, diffusion coefficients, initial conditions, boundary conditions, or any other well-defined variables in the kinetic equations. These parameters are generally considered to be functions of position and/or time. Derivation of the governing equations for the sensitivities and the Green's funciton are presented. The physical interpretation of the Green's function and sensitivities is given along with a discussion of the relation of this work to earlier research

  17. Compilation and network analyses of cambrian food webs.

    Directory of Open Access Journals (Sweden)

    Jennifer A Dunne

    2008-04-01

    Full Text Available A rich body of empirically grounded theory has developed about food webs--the networks of feeding relationships among species within habitats. However, detailed food-web data and analyses are lacking for ancient ecosystems, largely because of the low resolution of taxa coupled with uncertain and incomplete information about feeding interactions. These impediments appear insurmountable for most fossil assemblages; however, a few assemblages with excellent soft-body preservation across trophic levels are candidates for food-web data compilation and topological analysis. Here we present plausible, detailed food webs for the Chengjiang and Burgess Shale assemblages from the Cambrian Period. Analyses of degree distributions and other structural network properties, including sensitivity analyses of the effects of uncertainty associated with Cambrian diet designations, suggest that these early Paleozoic communities share remarkably similar topology with modern food webs. Observed regularities reflect a systematic dependence of structure on the numbers of taxa and links in a web. Most aspects of Cambrian food-web structure are well-characterized by a simple "niche model," which was developed for modern food webs and takes into account this scale dependence. However, a few aspects of topology differ between the ancient and recent webs: longer path lengths between species and more species in feeding loops in the earlier Chengjiang web, and higher variability in the number of links per species for both Cambrian webs. Our results are relatively insensitive to the exclusion of low-certainty or random links. The many similarities between Cambrian and recent food webs point toward surprisingly strong and enduring constraints on the organization of complex feeding interactions among metazoan species. The few differences could reflect a transition to more strongly integrated and constrained trophic organization within ecosystems following the rapid

  18. Specifying exposure classification parameters for sensitivity analysis: family breast cancer history

    Directory of Open Access Journals (Sweden)

    Anne M Jurek

    2009-07-01

    Full Text Available Anne M Jurek,1,2 Timothy L Lash,3 George Maldonado41Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA; 2University of Minnesota Masonic Cancer Center, Minneapolis, MN, USA; 3Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA; 4Division of Environmental Health Sciences, University of Minnesota School of Public Health, Minneapolis, MN,  USAAbstract: One of the challenges to implementing sensitivity analysis for exposure misclassification is the process of specifying the classification proportions (eg, sensitivity and specificity. The specification of these assignments is guided by three sources of information: estimates from validation studies, expert judgment, and numerical constraints given the data. The purpose of this teaching paper is to describe the process of using validation data and expert judgment to adjust a breast cancer odds ratio for misclassification of family breast cancer history. The parameterization of various point estimates and prior distributions for sensitivity and specificity were guided by external validation data and expert judgment. We used both nonprobabilistic and probabilistic sensitivity analyses to investigate the dependence of the odds ratio estimate on the classification error. With our assumptions, a wider range of odds ratios adjusted for family breast cancer history misclassification resulted than portrayed in the conventional frequentist confidence interval.Keywords: breast cancer, family cancer history, sensitivity analysis, sensitivity, specificity

  19. Pseudo-dynamic source modelling with 1-point and 2-point statistics of earthquake source parameters

    KAUST Repository

    Song, S. G.

    2013-12-24

    Ground motion prediction is an essential element in seismic hazard and risk analysis. Empirical ground motion prediction approaches have been widely used in the community, but efficient simulation-based ground motion prediction methods are needed to complement empirical approaches, especially in the regions with limited data constraints. Recently, dynamic rupture modelling has been successfully adopted in physics-based source and ground motion modelling, but it is still computationally demanding and many input parameters are not well constrained by observational data. Pseudo-dynamic source modelling keeps the form of kinematic modelling with its computational efficiency, but also tries to emulate the physics of source process. In this paper, we develop a statistical framework that governs the finite-fault rupture process with 1-point and 2-point statistics of source parameters in order to quantify the variability of finite source models for future scenario events. We test this method by extracting 1-point and 2-point statistics from dynamically derived source models and simulating a number of rupture scenarios, given target 1-point and 2-point statistics. We propose a new rupture model generator for stochastic source modelling with the covariance matrix constructed from target 2-point statistics, that is, auto- and cross-correlations. Our sensitivity analysis of near-source ground motions to 1-point and 2-point statistics of source parameters provides insights into relations between statistical rupture properties and ground motions. We observe that larger standard deviation and stronger correlation produce stronger peak ground motions in general. The proposed new source modelling approach will contribute to understanding the effect of earthquake source on near-source ground motion characteristics in a more quantitative and systematic way.

  20. Lefschetz Fixed Point Theorem and Lattice Points in Convex Polytopes

    OpenAIRE

    Sardo-Infirri, Sacha

    1993-01-01

    A simple convex lattice polytope $\\Box$ defines a torus-equivariant line bundle $\\LB$ over a toric variety $\\XB.$ Atiyah and Bott's Lefschetz fixed-point theorem is applied to the torus action on the $d''$-complex of $\\LB$ and information is obtained about the lattice points of $\\Box$. In particular an explicit formula is derived, computing the number of lattice points and the volume of $\\Box$ in terms of geometric data at its extreme points. We show this to be equivalent the results of Brion...

  1. Microcephaly in Pernambuco State, Brazil: epidemiological characteristics and evaluation of the diagnostic accuracy of cutoff points for reporting suspected cases.

    Science.gov (United States)

    Souza, Wayner Vieira de; Araújo, Thalia Velho Barreto de; Albuquerque, Maria de Fátima P Militão; Braga, Maria Cynthia; Ximenes, Ricardo Arraes de Alencar; Miranda-Filho, Demócrito de Barros; Bezerra, Luciana Caroline Albuquerque; Dimech, George Santiago; Carvalho, Patrícia Ismael de; Assunção, Romildo Siqueira de; Santos, Roselene Hans; Oliveira, Wanderson Kleber de; Rodrigues, Laura Cunha; Martelli, Celina Maria Turchi

    2016-01-01

    The increase in the number of reported cases of microcephaly in Pernambuco State, and Northeast Brazil, characterized an epidemic that led the Brazilian Ministry of Health to declare a national public health emergency. The Brazilian Ministry of Health initially defined suspected cases as newborns with gestational age (GA) ≥ 37 weeks and head circumference (HC) ≤ 33cm, but in December 2015 this cutoff was lowered to 32cm. The current study aimed to estimate the accuracy, sensitivity, and specificity of different cutoff points for HC, using ROC curves, with the Fenton and Intergrowth (2014) curves as the gold standard. The study described cases reported in Pernambuco from August 8 to November 28, 2015, according to sex and GA categories. The Fenton and Intergrowth methods provide HC growth curves according to GA and sex, and microcephaly is defined as a newborn with HC below the 3rd percentile in these distributions. Of the 684 reported cases, 599 were term or post-term neonates. For these, the analyses with ROC curves show that according to the Fenton criterion the cutoff point with the largest area under the ROC curve, with sensitivity greater than specificity, is 32cm for both sexes. Using the Intergrowth method and following the same criteria, the cutoff points are 32cm and 31.5cm for males and females, respectively. The cutoff point identified by the Fenton method (32cm) coincided with the Brazilian Ministry of Health recommendation. Adopting Intergrowth as the standard, the choice would be 32cm for males and 31.5cm for females. The study identified the need to conduct critical and on-going analyses to evaluate cutoff points, including other characteristics for microcephaly case definition.

  2. How sensitizing is chlorocresol?

    DEFF Research Database (Denmark)

    Andersen, Klaus Ejner; Hamann, K

    1984-01-01

    Chlorocresol is a biocide with widespread use in industry and pharmaceutical products. It is an occasional human contact sensitizer. The sensitizing potential of chlorocresol was judged strong using the guinea pig maximization test (GPMT) and doubtful in the less sensitive open epicutaneous test ...

  3. Sensitivity analysis of a PWR pressurizer

    International Nuclear Information System (INIS)

    Bruel, Renata Nunes

    1997-01-01

    A sensitivity analysis relative to the parameters and modelling of the physical process in a PWR pressurizer has been performed. The sensitivity analysis was developed by implementing the key parameters and theoretical model lings which generated a comprehensive matrix of influences of each changes analysed. The major influences that have been observed were the flashing phenomenon and the steam condensation on the spray drops. The present analysis is also applicable to the several theoretical and experimental areas. (author)

  4. An extensible analysable system model

    DEFF Research Database (Denmark)

    Probst, Christian W.; Hansen, Rene Rydhof

    2008-01-01

    Analysing real-world systems for vulnerabilities with respect to security and safety threats is a difficult undertaking, not least due to a lack of availability of formalisations for those systems. While both formalisations and analyses can be found for artificial systems such as software......, this does not hold for real physical systems. Approaches such as threat modelling try to target the formalisation of the real-world domain, but still are far from the rigid techniques available in security research. Many currently available approaches to assurance of critical infrastructure security...... are based on (quite successful) ad-hoc techniques. We believe they can be significantly improved beyond the state-of-the-art by pairing them with static analyses techniques. In this paper we present an approach to both formalising those real-world systems, as well as providing an underlying semantics, which...

  5. Sample preparation in foodomic analyses.

    Science.gov (United States)

    Martinović, Tamara; Šrajer Gajdošik, Martina; Josić, Djuro

    2018-04-16

    Representative sampling and adequate sample preparation are key factors for successful performance of further steps in foodomic analyses, as well as for correct data interpretation. Incorrect sampling and improper sample preparation can be sources of severe bias in foodomic analyses. It is well known that both wrong sampling and sample treatment cannot be corrected anymore. These, in the past frequently neglected facts, are now taken into consideration, and the progress in sampling and sample preparation in foodomics is reviewed here. We report the use of highly sophisticated instruments for both high-performance and high-throughput analyses, as well as miniaturization and the use of laboratory robotics in metabolomics, proteomics, peptidomics and genomics. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  6. Mitogenomic analyses from ancient DNA

    DEFF Research Database (Denmark)

    Paijmans, Johanna L. A.; Gilbert, Tom; Hofreiter, Michael

    2013-01-01

    The analysis of ancient DNA is playing an increasingly important role in conservation genetic, phylogenetic and population genetic analyses, as it allows incorporating extinct species into DNA sequence trees and adds time depth to population genetics studies. For many years, these types of DNA...... analyses (whether using modern or ancient DNA) were largely restricted to the analysis of short fragments of the mitochondrial genome. However, due to many technological advances during the past decade, a growing number of studies have explored the power of complete mitochondrial genome sequences...... (mitogenomes). Such studies were initially limited to analyses of extant organisms, but developments in both DNA sequencing technologies and general methodological aspects related to working with degraded DNA have resulted in complete mitogenomes becoming increasingly popular for ancient DNA studies as well...

  7. Linear covariance analysis for gimbaled pointing systems

    Science.gov (United States)

    Christensen, Randall S.

    Linear covariance analysis has been utilized in a wide variety of applications. Historically, the theory has made significant contributions to navigation system design and analysis. More recently, the theory has been extended to capture the combined effect of navigation errors and closed-loop control on the performance of the system. These advancements have made possible rapid analysis and comprehensive trade studies of complicated systems ranging from autonomous rendezvous to vehicle ascent trajectory analysis. Comprehensive trade studies are also needed in the area of gimbaled pointing systems where the information needs are different from previous applications. It is therefore the objective of this research to extend the capabilities of linear covariance theory to analyze the closed-loop navigation and control of a gimbaled pointing system. The extensions developed in this research include modifying the linear covariance equations to accommodate a wider variety of controllers. This enables the analysis of controllers common to gimbaled pointing systems, with internal states and associated dynamics as well as actuator command filtering and auxiliary controller measurements. The second extension is the extraction of power spectral density estimates from information available in linear covariance analysis. This information is especially important to gimbaled pointing systems where not just the variance but also the spectrum of the pointing error impacts the performance. The extended theory is applied to a model of a gimbaled pointing system which includes both flexible and rigid body elements as well as input disturbances, sensor errors, and actuator errors. The results of the analysis are validated by direct comparison to a Monte Carlo-based analysis approach. Once the developed linear covariance theory is validated, analysis techniques that are often prohibitory with Monte Carlo analysis are used to gain further insight into the system. These include the creation

  8. Making Sense of Boiling Points and Melting Points

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 12; Issue 6. Making Sense of Boiling Points and Melting Points. S Prahlada Rao Shravan Sunkada. General Article Volume 12 Issue 6 June 2007 pp 43-57. Fulltext. Click here to view fulltext PDF. Permanent link:

  9. Approximation point par point pour la resolution du probleme de ...

    African Journals Online (AJOL)

    Approximation point par point pour la resolution du probleme de dirichlet dans un disque pour l'equation elliptique du second ordre a coefficients constants dans le cas ou les racines de l'equation caracteristique sont distinctes. AMJ Tchalla, K Tcharie ...

  10. Feasibility Analyses of Integrated Broiler Production

    Directory of Open Access Journals (Sweden)

    L. Komalasari

    2010-12-01

    Full Text Available The major obstacles in the development of broiler raising is the expensive price of feed and the fluctuative price of DOCs. The cheap price of imported leg quarters reduces the competitiveness of the local broilers. Therefore, an effort to increase production efficiency is needed through integration between broiler raising and corn farmers and feed producers (integrated farming. The purpose of this study is to analyze the feasibility of integrating broiler raising with corn cultivation and feed production. Besides that, a simulation was conducted to analyze the effects of DOC price changes, broiler price and production capacity. The analyses showed that integrated farming and a mere combination between broiler raising and feed factory of a 10,000 bird capacity is not financially feasible. Increasing the production to 25,000 broiler chickens will make the integrated farming financially feasible. Unintegrated broiler raising is relatively sensitive to broiler price decreases and DOC price increases compared to integrated farming.

  11. Null point of discrimination in crustacean polarisation vision.

    Science.gov (United States)

    How, Martin J; Christy, John; Roberts, Nicholas W; Marshall, N Justin

    2014-07-15

    The polarisation of light is used by many species of cephalopods and crustaceans to discriminate objects or to communicate. Most visual systems with this ability, such as that of the fiddler crab, include receptors with photopigments that are oriented horizontally and vertically relative to the outside world. Photoreceptors in such an orthogonal array are maximally sensitive to polarised light with the same fixed e-vector orientation. Using opponent neural connections, this two-channel system may produce a single value of polarisation contrast and, consequently, it may suffer from null points of discrimination. Stomatopod crustaceans use a different system for polarisation vision, comprising at least four types of polarisation-sensitive photoreceptor arranged at 0, 45, 90 and 135 deg relative to each other, in conjunction with extensive rotational eye movements. This anatomical arrangement should not suffer from equivalent null points of discrimination. To test whether these two systems were vulnerable to null points, we presented the fiddler crab Uca heteropleura and the stomatopod Haptosquilla trispinosa with polarised looming stimuli on a modified LCD monitor. The fiddler crab was less sensitive to differences in the degree of polarised light when the e-vector was at -45 deg than when the e-vector was horizontal. In comparison, stomatopods showed no difference in sensitivity between the two stimulus types. The results suggest that fiddler crabs suffer from a null point of sensitivity, while stomatopods do not. © 2014. Published by The Company of Biologists Ltd.

  12. Developing cultural sensitivity

    DEFF Research Database (Denmark)

    Ruddock, Heidi; Turner, deSalle

    2007-01-01

    Title. Developing cultural sensitivity: nursing students’ experiences of a study abroad programme Aim. This paper is a report of a study to explore whether having an international learning experience as part of a nursing education programme promoted cultural sensitivity in nursing students....... Background. Many countries are becoming culturally diverse, but healthcare systems and nursing education often remain mono-cultural and focused on the norms and needs of the majority culture. To meet the needs of all members of multicultural societies, nurses need to develop cultural sensitivity...... on the deliver of culturally sensitive care. Keywords: cultural sensitivity, nursing students, empirical research, report, interviews, study abroad programmes, phenomenology...

  13. Sensitivity analysis using probability bounding

    International Nuclear Information System (INIS)

    Ferson, Scott; Troy Tucker, W.

    2006-01-01

    Probability bounds analysis (PBA) provides analysts a convenient means to characterize the neighborhood of possible results that would be obtained from plausible alternative inputs in probabilistic calculations. We show the relationship between PBA and the methods of interval analysis and probabilistic uncertainty analysis from which it is jointly derived, and indicate how the method can be used to assess the quality of probabilistic models such as those developed in Monte Carlo simulations for risk analyses. We also illustrate how a sensitivity analysis can be conducted within a PBA by pinching inputs to precise distributions or real values

  14. Research on Nonlinear Feature of Electrical Resistance of Acupuncture Points

    Directory of Open Access Journals (Sweden)

    Jianzi Wei

    2012-01-01

    Full Text Available A highly sensitive volt-ampere characteristics detecting system was applied to measure the volt-ampere curves of nine acupuncture points, LU9, HT7, LI4, PC6, ST36, SP6, KI3, LR3, and SP3, and corresponding nonacupuncture points bilaterally from 42 healthy volunteers. Electric currents intensity was increased from 0 μA to 20 μA and then returned to 0 μA again. The results showed that the volt-ampere curves of acupuncture points had nonlinear property and magnetic hysteresis-like feature. On all acupuncture point spots, the volt-ampere areas of the increasing phase were significantly larger than that of the decreasing phase (P<0.01. The volt-ampere areas of ten acupuncture point spots were significantly smaller than those of the corresponding nonacupuncture point spots when intensity was increase (P<0.05~P<0.001. And when intensity was decrease, eleven acupuncture point spots showed the same property as above (P<0.05~P<0.001, while two acupuncture point spots showed opposite phenomenon in which the areas of two acupuncture point spots were larger than those of the corresponding nonacupuncture point spots (P<0.05~P<0.01. These results show that the phenomenon of low skin resistance does not exist to all acupuncture points.

  15. Time Stamps for Fixed-Point Approximation

    DEFF Research Database (Denmark)

    Damian, Daniela

    2001-01-01

    Time stamps were introduced in Shivers's PhD thesis for approximating the result of a control-flow analysis. We show them to be suitable for computing program analyses where the space of results (e.g., control-flow graphs) is large. We formalize time-stamping as a top-down, fixed-point approximat......Time stamps were introduced in Shivers's PhD thesis for approximating the result of a control-flow analysis. We show them to be suitable for computing program analyses where the space of results (e.g., control-flow graphs) is large. We formalize time-stamping as a top-down, fixed...

  16. Calibrated HDRI in 3D point clouds

    DEFF Research Database (Denmark)

    Bülow, Katja; Tamke, Martin

    2017-01-01

    the challenges of dynamic smart lighting planning in outdoor urban space. This paper presents findings on how 3D capturing of outdoor environments combined with HDRI establishes a new way for analysing and representing the spatial distribution of light in combination with luminance data.......3D-scanning technologies and point clouds as means for spatial representation introduce a new paradigm to the measuring and mapping of physical artefacts and space. This technology also offers possibilities for the measuring and mapping of outdoor urban lighting and has the potential to meet...

  17. Electrochemical biosensors for hormone analyses.

    Science.gov (United States)

    Bahadır, Elif Burcu; Sezgintürk, Mustafa Kemal

    2015-06-15

    Electrochemical biosensors have a unique place in determination of hormones due to simplicity, sensitivity, portability and ease of operation. Unlike chromatographic techniques, electrochemical techniques used do not require pre-treatment. Electrochemical biosensors are based on amperometric, potentiometric, impedimetric, and conductometric principle. Amperometric technique is a commonly used one. Although electrochemical biosensors offer a great selectivity and sensitivity for early clinical analysis, the poor reproducible results, difficult regeneration steps remain primary challenges to the commercialization of these biosensors. This review summarizes electrochemical (amperometric, potentiometric, impedimetric and conductometric) biosensors for hormone detection for the first time in the literature. After a brief description of the hormones, the immobilization steps and analytical performance of these biosensors are summarized. Linear ranges, LODs, reproducibilities, regenerations of developed biosensors are compared. Future outlooks in this area are also discussed. Copyright © 2014 Elsevier B.V. All rights reserved.

  18. Descriptive Analyses of Mechanical Systems

    DEFF Research Database (Denmark)

    Andreasen, Mogens Myrup; Hansen, Claus Thorp

    2003-01-01

    Forord Produktanalyse og teknologianalyse kan gennmføres med et bredt socio-teknisk sigte med henblik på at forstå kulturelle, sociologiske, designmæssige, forretningsmæssige og mange andre forhold. Et delområde heri er systemisk analyse og beskrivelse af produkter og systemer. Nærværende kompend...

  19. Millifluidic droplet analyser for microbiology

    NARCIS (Netherlands)

    Baraban, L.; Bertholle, F.; Salverda, M.L.M.; Bremond, N.; Panizza, P.; Baudry, J.; Visser, de J.A.G.M.; Bibette, J.

    2011-01-01

    We present a novel millifluidic droplet analyser (MDA) for precisely monitoring the dynamics of microbial populations over multiple generations in numerous (=103) aqueous emulsion droplets (100 nL). As a first application, we measure the growth rate of a bacterial strain and determine the minimal

  20. Myofascial trigger points: spontaneous electrical activity and its consequences for pain induction and propagation

    Science.gov (United States)

    2011-01-01

    Active myofascial trigger points are one of the major peripheral pain generators for regional and generalized musculoskeletal pain conditions. Myofascial trigger points are also the targets for acupuncture and/or dry needling therapies. Recent evidence in the understanding of the pathophysiology of myofascial trigger points supports The Integrated Hypothesis for the trigger point formation; however unanswered questions remain. Current evidence shows that spontaneous electrical activity at myofascial trigger point originates from the extrafusal motor endplate. The spontaneous electrical activity represents focal muscle fiber contraction and/or muscle cramp potentials depending on trigger point sensitivity. Local pain and tenderness at myofascial trigger points are largely due to nociceptor sensitization with a lesser contribution from non-nociceptor sensitization. Nociceptor and non-nociceptor sensitization at myofascial trigger points may be part of the process of muscle ischemia associated with sustained focal muscle contraction and/or muscle cramps. Referred pain is dependent on the sensitivity of myofascial trigger points. Active myofascial trigger points may play an important role in the transition from localized pain to generalized pain conditions via the enhanced central sensitization, decreased descending inhibition and dysfunctional motor control strategy. PMID:21439050

  1. Myofascial trigger points: spontaneous electrical activity and its consequences for pain induction and propagation.

    Science.gov (United States)

    Ge, Hong-You; Fernández-de-Las-Peñas, César; Yue, Shou-Wei

    2011-03-25

    Active myofascial trigger points are one of the major peripheral pain generators for regional and generalized musculoskeletal pain conditions. Myofascial trigger points are also the targets for acupuncture and/or dry needling therapies. Recent evidence in the understanding of the pathophysiology of myofascial trigger points supports The Integrated Hypothesis for the trigger point formation; however unanswered questions remain. Current evidence shows that spontaneous electrical activity at myofascial trigger point originates from the extrafusal motor endplate. The spontaneous electrical activity represents focal muscle fiber contraction and/or muscle cramp potentials depending on trigger point sensitivity. Local pain and tenderness at myofascial trigger points are largely due to nociceptor sensitization with a lesser contribution from non-nociceptor sensitization. Nociceptor and non-nociceptor sensitization at myofascial trigger points may be part of the process of muscle ischemia associated with sustained focal muscle contraction and/or muscle cramps. Referred pain is dependent on the sensitivity of myofascial trigger points. Active myofascial trigger points may play an important role in the transition from localized pain to generalized pain conditions via the enhanced central sensitization, decreased descending inhibition and dysfunctional motor control strategy.

  2. Myofascial trigger points: spontaneous electrical activity and its consequences for pain induction and propagation

    Directory of Open Access Journals (Sweden)

    Fernández-de-las-Peñas César

    2011-03-01

    Full Text Available Abstract Active myofascial trigger points are one of the major peripheral pain generators for regional and generalized musculoskeletal pain conditions. Myofascial trigger points are also the targets for acupuncture and/or dry needling therapies. Recent evidence in the understanding of the pathophysiology of myofascial trigger points supports The Integrated Hypothesis for the trigger point formation; however unanswered questions remain. Current evidence shows that spontaneous electrical activity at myofascial trigger point originates from the extrafusal motor endplate. The spontaneous electrical activity represents focal muscle fiber contraction and/or muscle cramp potentials depending on trigger point sensitivity. Local pain and tenderness at myofascial trigger points are largely due to nociceptor sensitization with a lesser contribution from non-nociceptor sensitization. Nociceptor and non-nociceptor sensitization at myofascial trigger points may be part of the process of muscle ischemia associated with sustained focal muscle contraction and/or muscle cramps. Referred pain is dependent on the sensitivity of myofascial trigger points. Active myofascial trigger points may play an important role in the transition from localized pain to generalized pain conditions via the enhanced central sensitization, decreased descending inhibition and dysfunctional motor control strategy.

  3. Brocard Point and Euler Function

    Science.gov (United States)

    Sastry, K. R. S.

    2007-01-01

    This paper takes a known point from Brocard geometry, a known result from the geometry of the equilateral triangle, and bring in Euler's [empty set] function. It then demonstrates how to obtain new Brocard Geometric number theory results from them. Furthermore, this paper aims to determine a [triangle]ABC whose Crelle-Brocard Point [omega]…

  4. Model plant Key Measurement Points

    International Nuclear Information System (INIS)

    Schneider, R.A.

    1984-01-01

    For IAEA safeguards a Key Measurement Point is defined as the location where nuclear material appears in such a form that it may be measured to determine material flow or inventory. This presentation describes in an introductory manner the key measurement points and associated measurements for the model plant used in this training course

  5. The Random Material Point Method

    NARCIS (Netherlands)

    Wang, B.; Vardon, P.J.; Hicks, M.A.

    2017-01-01

    The material point method is a finite element variant which allows the material, represented by a point-wise discretization, to move through the background mesh. This means that large deformations, such as those observed post slope failure, can be computed. By coupling this material level

  6. Mathematical points as didactical ideas

    DEFF Research Database (Denmark)

    Mogensen, Arne

    Mathematics teaching in Denmark was recently recommended better organized in sequences with clear mathematical pedagogical goals and a focus on mathematical points. In this paper I define a mathematical point and inform on coding of transcripts in a video based Danish research study on grade 8...

  7. Conditioning in spatial point processes

    DEFF Research Database (Denmark)

    Coeurjolly, Jean-Francois; Møller, Jesper; Waagepetersen, Rasmus

    This tutorial provides an introduction to conditioning in spatial point processes or so-called Palm distributions. Initially, in the context of finite point processes, we give an explicit definition of Palm distributions in terms of their density functions. Then we review Palm distributions...... in the general case. Finally we discuss some examples of specific models and applications...

  8. Review of NJ point system.

    Science.gov (United States)

    2013-03-01

    The purpose of this study is to investigate the comparative effectiveness of point-based versus incident-based : negligent driver monitoring systems and to explore how certain changes to the existing point-based system used in : New Jersey might impr...

  9. Improved Dynamic Planar Point Location

    DEFF Research Database (Denmark)

    Brodal, Gerth Stølting; Arge, Lars; Georgiadis, Loukas

    2006-01-01

    We develop the first linear-space data structures for dynamic planar point location in general subdivisions that achieve logarithmic query time and poly-logarithmic update time.......We develop the first linear-space data structures for dynamic planar point location in general subdivisions that achieve logarithmic query time and poly-logarithmic update time....

  10. Inertial Pointing and Positioning System

    Science.gov (United States)

    Yee, Robert (Inventor); Robbins, Fred (Inventor)

    1998-01-01

    An inertial pointing and control system and method for pointing to a designated target with known coordinates from a platform to provide accurate position, steering, and command information. The system continuously receives GPS signals and corrects Inertial Navigation System (INS) dead reckoning or drift errors. An INS is mounted directly on a pointing instrument rather than in a remote location on the platform for-monitoring the terrestrial position and instrument attitude. and for pointing the instrument at designated celestial targets or ground based landmarks. As a result. the pointing instrument and die INS move independently in inertial space from the platform since the INS is decoupled from the platform. Another important characteristic of the present system is that selected INS measurements are combined with predefined coordinate transformation equations and control logic algorithms under computer control in order to generate inertial pointing commands to the pointing instrument. More specifically. the computer calculates the desired instrument angles (Phi, Theta. Psi). which are then compared to the Euler angles measured by the instrument- mounted INS. and forms the pointing command error angles as a result of the compared difference.

  11. Response surface use in safety analyses

    International Nuclear Information System (INIS)

    Prosek, A.

    1999-01-01

    When thousands of complex computer code runs related to nuclear safety are needed for statistical analysis, the response surface is used to replace the computer code. The main purpose of the study was to develop and demonstrate a tool called optimal statistical estimator (OSE) intended for response surface generation of complex and non-linear phenomena. The performance of optimal statistical estimator was tested by the results of 59 different RELAP5/MOD3.2 code calculations of the small-break loss-of-coolant accident in a two loop pressurized water reactor. The results showed that OSE adequately predicted the response surface for the peak cladding temperature. Some good characteristic of the OSE like monotonic function between two neighbor points and independence on the number of output parameters suggest that OSE can be used for response surface generation of any safety or system parameter in the thermal-hydraulic safety analyses.(author)

  12. Nuclear data covariances and sensitivity analysis, validation of a methodology based on the perturbation theory; application to an innovative concept: the molten thorium salt fueled reactor; Analyses de sensibilite et d'incertitude de donnees nucleaires. Contribution a la validation d'une methodologie utilisant la theorie des perturbations; application a un concept innovant: reacteur a sels fondus thorium a spectre epithermique

    Energy Technology Data Exchange (ETDEWEB)

    Bidaud, A

    2005-10-15

    Neutron transport simulation of nuclear reactors is based on the knowledge of the neutron-nucleus interaction (cross-sections, fission neutron yields and spectra...) for the dozens of nuclei present in the core over a very large energy range (fractions of eV to several MeV). To obtain the goal of the sustainable development of nuclear power, future reactors must have new and more strict constraints to their design: optimization of ore materials will necessitate breeding (generation of fissile material from fertile material), and waste management will require transmutation. Innovative reactors that could achieve such objectives - generation IV or ADS (accelerator driven system) - are loaded with new fuels (thorium, heavy actinides) and function with neutron spectra for which nuclear data do not benefit from 50 years of industrial experience, and thus present particular challenges. After validation on an experimental reactor using an international benchmark, we take classical reactor physics tools along with available nuclear data uncertainties to calculate the sensitivities and uncertainties of the criticality and temperature coefficient of a thorium molten salt reactor. In addition, a study based on the important reaction rates for the calculation of cycle's equilibrium allows us to estimate the efficiency of different reprocessing strategies and the contribution of these reaction rates on the uncertainty of the breeding and then on the uncertainty of the size of the reprocessing plant. Finally, we use this work to propose an improvement of the high priority experimental request list. (author)

  13. A miniaturised, nested-cylindrical electrostatic analyser geometry for dual electron and ion, multi-energy measurements

    Energy Technology Data Exchange (ETDEWEB)

    Bedington, Robert, E-mail: r.bedington@nus.edu.sg; Kataria, Dhiren; Smith, Alan

    2015-09-01

    The CATS (Cylindrical And Tiny Spectrometer) electrostatic optics geometry features multiple nested cylindrical analysers to simultaneously measure multiple energies of electron and multiple energies of ion in a configuration that is targeted at miniaturisation and MEMS fabrication. In the prototyped model, two configurations of cylindrical analyser were used, featuring terminating side-plates that caused particle trajectories to either converge (C type) or diverge (D type) in the axial direction. Simulations show how these different electrode configurations affect the particle focussing and instrument parameters; C-type providing greater throughputs but D-type providing higher resolving powers. The simulations were additionally used to investigate unexpected plate spacing variations in the as-built model, revealing that the k-factors are most sensitive to the width of the inter-electrode spacing at its narrowest point. - Highlights: • A new nested cylindrical miniaturised electrostatic analyser geometry is described. • “Converging” (C) and “diverging” (D) type channel properties are investigated. • C channels are shown to have greater throughputs and D greater resolving powers. • Plate factors are shown to be sensitive to the minimum in inter-electrode spacing.

  14. NPDES permits and water analyses

    International Nuclear Information System (INIS)

    Pojasek, R.B.

    1975-01-01

    Provisions of the Federal Water Pollution Control Act, as amended by P. L. 92-500, including an explanation of the National Pollutant Discharge Elimination System (NPDES), and EPA's criteria for the analysis of pollutants are discussed. The need for a revision of current restrictive variance procedures is pointed out. References for the comparison of analytical methods for water pollutants under permits, including radioactive parameters, are tabulated. (U.S.)

  15. A miniaturised image based fluorescence detection system for point-of-care-testing of cocaine abuse

    Science.gov (United States)

    Walczak, Rafał; Krüger, Jan; Moynihan, Shane

    2015-08-01

    In this paper, we describe a miniaturised image-based fluorescence detection system and demonstrate its viability as a highly sensitive tool for point-of-care-analysis of drugs of abuse in human sweat with a focus on monitor individuals for drugs of abuse. Investigations of miniaturised and low power optoelectronic configurations and methodologies for real-time image analysis were successfully carried out. The miniaturised fluorescence detection system was validated against a reference detection system under controlled laboratory conditions by analysing spiked sweat samples in dip stick and then strip with sample pad. As a result of the validation studies, a 1 ng mL-1 limit of detection of cocaine in sweat and full agreement of test results with the reference detection system can be reported. Results of the investigations open the way towards a detection system that integrates a hand-held fluorescence reader and a wearable skinpatch, and which can collect and in situ analyse sweat for the presence of cocaine at any point for up to tenths hours.

  16. Sensitivity to coffee and subjective health

    NARCIS (Netherlands)

    Snel, J.; Koppes, L.L.J.; Twisk, J.W.

    2009-01-01

    The question was whether health complaints are associated with coffee consumption and self reported sensitivity to coffee. Participants were 89 men and 107 women, all coffee drinkers. Questionnaires were used at 2 points of time with an interval of 3.7 years. The correlations among coffee

  17. Context Sensitive Modeling of Cancer Drug Sensitivity.

    Directory of Open Access Journals (Sweden)

    Bo-Juen Chen

    Full Text Available Recent screening of drug sensitivity in large panels of cancer cell lines provides a valuable resource towards developing algorithms that predict drug response. Since more samples provide increased statistical power, most approaches to prediction of drug sensitivity pool multiple cancer types together without distinction. However, pan-cancer results can be misleading due to the confounding effects of tissues or cancer subtypes. On the other hand, independent analysis for each cancer-type is hampered by small sample size. To balance this trade-off, we present CHER (Contextual Heterogeneity Enabled Regression, an algorithm that builds predictive models for drug sensitivity by selecting predictive genomic features and deciding which ones should-and should not-be shared across different cancers, tissues and drugs. CHER provides significantly more accurate models of drug sensitivity than comparable elastic-net-based models. Moreover, CHER provides better insight into the underlying biological processes by finding a sparse set of shared and type-specific genomic features.

  18. Geodetic Control Points - Multi-State Control Point Database

    Data.gov (United States)

    NSGIC State | GIS Inventory — The Multi-State Control Point Database (MCPD) is a database of geodetic and mapping control covering Idaho and Montana. The control were submitted by registered land...

  19. Chronic Opioid Therapy and Central Sensitization in Sickle Cell Disease.

    Science.gov (United States)

    Carroll, C Patrick; Lanzkron, Sophie; Haywood, Carlton; Kiley, Kasey; Pejsa, Megan; Moscou-Jackson, Gyasi; Haythornthwaite, Jennifer A; Campbell, Claudia M

    2016-07-01

    Chronic opioid therapy (COT) for chronic non-cancer pain is frequently debated, and its effectiveness is unproven in sickle cell disease (SCD). The authors conducted a descriptive study among 83 adult SCD patients and compared the severity of disease and pain symptoms among those who were prescribed COT (n=29) with those who were not using COT. All patients completed baseline laboratory pain assessment and questionnaires between January 2010 and June 2014. Thereafter, participants recorded daily pain, crises, function, and healthcare utilization for 90 days using electronic diaries. Analyses were conducted shortly after the final diary data collection period. Patients on COT did not differ on age, sex, or measures of disease severity. However, patients on COT exhibited greater levels of clinical pain (particularly non-crisis); central sensitization; and depression and increased diary measures of pain severity, function, and healthcare utilization on crisis and non-crisis diary days, as well as a greater proportion of days in crisis. Including depressive symptoms in multivariate models did not change the associations between COT and pain, interference, central sensitization, or utilization. Additionally, participants not on COT displayed the expected positive relationship between central sensitization and clinical pain, whereas those on COT demonstrated no such relationship, despite having both higher central sensitization and higher clinical pain. Overall, the results point out a high symptom burden in SCD patients on COT, including those on high-dose COT, and suggest that nociceptive processing in SCD patients on COT differs from those who are not. Copyright © 2016 American Journal of Preventive Medicine. Published by Elsevier Inc. All rights reserved.

  20. An optical fiber point liquid level sensor

    Science.gov (United States)

    Zhang, Wei; Gong, Ying; Ge, Junfeng; Hua, Bin; Zhang, Hongjie; Ye, Lin

    2015-10-01

    An optical fiber sensor to accurately judge the level of a point is presented in this paper. Three fibers are used in the sensor, one as the source to emit infrared light, and the others as the differential inputs to absorb the scattering of light. Adopting a differential structure of dual signal fibers helps removing the interference of external environment and the change of the intensity of the light source. When the sensor contacts the liquid, the emitted light will be scatted by the liquid so that the output voltage will have significant difference from it when the sensor is above the liquid. A 45 degree oblique end-face of fibers is not just used to reduce the adhesion of liquid but also can increase discrepancy between differential inputs due to different scattered light intensity at different position, and then enhance the sensitivity. Base on this point, the optical fiber point liquid level sensor is designed and its working performance is investigated by experiments. The experimental results indicated stability, accuracy and excellent performance in the use of this sensor to measure the status of liquid level. And the safety will be ensured for the characteristic of fiber and excellent electrical isolation.

  1. Hawaii ESI: INVERTPT (Invertebrate Points)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains sensitive biological resource data for native stream invertebrates, anchialine pool invertebrates, and threatened/endangered terrestrial...

  2. Hawaii ESI: FISHPT (Fish Points)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains sensitive biological resource data for native stream and anchialine pool fish species in coastal Hawaii. (Anchialine pools are small,...

  3. Is it pointing to grasping or grasping pointing?

    Science.gov (United States)

    Savelsbergh, G J; Van der Kamp, J

    1999-07-01

    The Smeets and Brenner view on grasping is simple: grasping is in fact pointing. In our comments we examine the model beyond the reach-to-grasp task, namely, by grasping (without reaching) of moving objects and eating. The model fits the data of both tasks. Although generalization of a model to different tasks usually strengthens its acceptance, in the present case it reveals its shortcomings, namely, both tasks include a clear grasping component that is hard to accept as pointing.

  4. Workload analyse of assembling process

    Science.gov (United States)

    Ghenghea, L. D.

    2015-11-01

    The workload is the most important indicator for managers responsible of industrial technological processes no matter if these are automated, mechanized or simply manual in each case, machines or workers will be in the focus of workload measurements. The paper deals with workload analyses made to a most part manual assembling technology for roller bearings assembling process, executed in a big company, with integrated bearings manufacturing processes. In this analyses the delay sample technique have been used to identify and divide all bearing assemblers activities, to get information about time parts from 480 minutes day work time that workers allow to each activity. The developed study shows some ways to increase the process productivity without supplementary investments and also indicated the process automation could be the solution to gain maximum productivity.

  5. Dosimetric adaptive IMRT driven by fiducial points

    International Nuclear Information System (INIS)

    Crijns, Wouter; Van Herck, Hans; Defraene, Gilles; Van den Bergh, Laura; Haustermans, Karin; Slagmolen, Pieter; Maes, Frederik; Van den Heuvel, Frank

    2014-01-01

    Purpose: Intensity modulated radiotherapy (IMRT) and volumetric modulated arc therapy have become standard treatments but are more sensitive to anatomical variations than 3D conformal techniques. To correct for inter- and intrafraction anatomical variations, fast and easy to implement methods are needed. Here, the authors propose a full dosimetric IMRT correction that finds a compromise in-between basic repositioning (the current clinical practice) and full replanning. It simplifies replanning by avoiding a recontouring step and a full dose calculation. It surpasses repositioning by updating the preoptimized fluence and monitor units (MU) using a limited number of fiducial points and a pretreatment (CB)CT. To adapt the fluence the fiducial points were projected in the beam's eye view (BEV). To adapt the MUs, point dose calculation towards the same fiducial points were performed. The proposed method is intrinsically fast and robust, and simple to understand for operators, because of the use of only four fiducial points and the beam data based point dose calculations. Methods: To perform our dosimetric adaptation, two fluence corrections in the BEV are combined with two MU correction steps along the beam's path. (1) A transformation of the fluence map such that it is realigned with the current target geometry. (2) A correction for an unintended scaling of the penumbra margin when the treatment beams scale to the current target size. (3) A correction for the target depth relative to the body contour and (4) a correction for the target distance to the source. The impact of the correction strategy and its individual components was evaluated by simulations on a virtual prostate phantom. This heterogeneous reference phantom was systematically subjected to population based prostate transformations to simulate interfraction variations. Additionally, a patient example illustrated the clinical practice. The correction strategy was evaluated using both dosimetric

  6. Reproducibility of neuroimaging analyses across operating systems.

    Science.gov (United States)

    Glatard, Tristan; Lewis, Lindsay B; Ferreira da Silva, Rafael; Adalat, Reza; Beck, Natacha; Lepage, Claude; Rioux, Pierre; Rousseau, Marc-Etienne; Sherif, Tarek; Deelman, Ewa; Khalili-Mahani, Najmeh; Evans, Alan C

    2015-01-01

    Neuroimaging pipelines are known to generate different results depending on the computing platform where they are compiled and executed. We quantify these differences for brain tissue classification, fMRI analysis, and cortical thickness (CT) extraction, using three of the main neuroimaging packages (FSL, Freesurfer and CIVET) and different versions of GNU/Linux. We also identify some causes of these differences using library and system call interception. We find that these packages use mathematical functions based on single-precision floating-point arithmetic whose implementations in operating systems continue to evolve. While these differences have little or no impact on simple analysis pipelines such as brain extraction and cortical tissue classification, their accumulation creates important differences in longer pipelines such as subcortical tissue classification, fMRI analysis, and cortical thickness extraction. With FSL, most Dice coefficients between subcortical classifications obtained on different operating systems remain above 0.9, but values as low as 0.59 are observed. Independent component analyses (ICA) of fMRI data differ between operating systems in one third of the tested subjects, due to differences in motion correction. With Freesurfer and CIVET, in some brain regions we find an effect of build or operating system on cortical thickness. A first step to correct these reproducibility issues would be to use more precise representations of floating-point numbers in the critical sections of the pipelines. The numerical stability of pipelines should also be reviewed.

  7. Safety analyses of surface facilities

    International Nuclear Information System (INIS)

    Anspach, W.; Baran, A.; Dorst, H.J.; Eifert, B.; Gruen, M.; Behrendt, V.; Berkhan, W.; Dincklage, R.D. v.; Doehler, J.; Bruecher, H.

    1981-01-01

    The investigations were carried out using the example of the Gorleben waste disposal center and the planning documents established for this center. The safety analyses refer to the transport of spent fuel elements, the water-cooled interin storage and the reprocessing stage. Regarding the risk analysis of the technical systems the dynamics of the courses of incidents can be better taken into account by doing a methodical development. (DG) [de

  8. Technical center for transportation analyses

    International Nuclear Information System (INIS)

    Foley, J.T.

    1978-01-01

    A description is presented of an information search/retrieval/research activity of Sandia Laboratories which provides technical environmental information which may be used in transportation risk analyses, environmental impact statements, development of design and test criteria for packaging of energy materials, and transportation mode research studies. General activities described are: (1) history of center development; (2) environmental information storage/retrieval system; (3) information searches; (4) data needs identification; and (5) field data acquisition system and applications

  9. Methodology of cost benefit analyses

    International Nuclear Information System (INIS)

    Patrik, M.; Babic, P.

    2000-10-01

    The report addresses financial aspects of proposed investments and other steps which are intended to contribute to nuclear safety. The aim is to provide introductory insight into the procedures and potential of cost-benefit analyses as a routine guide when making decisions on costly provisions as one of the tools to assess whether a particular provision is reasonable. The topic is applied to the nuclear power sector. (P.A.)

  10. Uncertainty in Operational Atmospheric Analyses and Re-Analyses

    Science.gov (United States)

    Langland, R.; Maue, R. N.

    2016-12-01

    This talk will describe uncertainty in atmospheric analyses of wind and temperature produced by operational forecast models and in re-analysis products. Because the "true" atmospheric state cannot be precisely quantified, there is necessarily error in every atmospheric analysis, and this error can be estimated by computing differences ( variance and bias) between analysis products produced at various centers (e.g., ECMWF, NCEP, U.S Navy, etc.) that use independent data assimilation procedures, somewhat different sets of atmospheric observations and forecast models with different resolutions, dynamical equations, and physical parameterizations. These estimates of analysis uncertainty provide a useful proxy to actual analysis error. For this study, we use a unique multi-year and multi-model data archive developed at NRL-Monterey. It will be shown that current uncertainty in atmospheric analyses is closely correlated with the geographic distribution of assimilated in-situ atmospheric observations, especially those provided by high-accuracy radiosonde and commercial aircraft observations. The lowest atmospheric analysis uncertainty is found over North America, Europe and Eastern Asia, which have the largest numbers of radiosonde and commercial aircraft observations. Analysis uncertainty is substantially larger (by factors of two to three times) in most of the Southern hemisphere, the North Pacific ocean, and under-developed nations of Africa and South America where there are few radiosonde or commercial aircraft data. It appears that in regions where atmospheric analyses depend primarily on satellite radiance observations, analysis uncertainty of both temperature and wind remains relatively high compared to values found over North America and Europe.

  11. A software program for quantitative analysis of alveolar oxygen partial pressure (p{sub A}O{sub 2}) with oxygen-sensitive {sup 3}He-MRI; Ein Auswerteprogramm zur quantitativen Analyse von Messungen des alveolaeren Sauerstoffpartialdrucks (p{sub A}O{sub 2}) mit der sauerstoffsensitiven {sup 3}He-MR-Tomographie

    Energy Technology Data Exchange (ETDEWEB)

    Lehmann, F.; Gast, K.K.; Schreiber, W.G. [Mainz Univ. (Germany). Klinik und Poliklinik fuer Radiologie; Eberle, B.; Markstaller, K. [Universitaet Mainz (Germany). Klinik fuer Anaesthesiologie; Schmiedeskamp, J. [Mainz Univ. (Germany). Inst. fuer Physik; Bluemler, P. [Max-Planck-Institut fuer Polymerforschung, Mainz (Germany); Kauczor, H.-U. [Mainz Univ. (Germany). Klinik und Poliklinik fuer Radiologie; Deutsches Krebsforschungszentrum, Heidelberg (Germany)

    2004-10-01

    Purpose: To develop a software tool for quantitative analysis of alveolar oxygen partial pressure (p{sub A}O{sub 2}) as well as its time course during apnea. Material and Methods: T{sub 1}-relaxation times of hyperpolarized {sup 3}He are reduced by paramagnetic oxygen rendering {sup 3}He-MRI sensitive to oxygen and thus allowing the assessment of the local oxygen partial pressure in the pulmonary airspaces. Oxygen-related relaxation and loss of polarization by RF-excitation can be discriminated by acquiring two image series with varying interscan delay and/or flip angles. Software was developed to calculate the p{sub A}O{sub 2} and the decay rate in user-defined regions of interest (ROIs) automatically. Moreover, parameter maps can be calculated. In addition to the analysis of 2-dimensional data sets, the software allows the evaluation of 3-dimensional measurements for the first time. Artifacts due to lung motion were reduced by implementing a motion correction algorithm. Results: The software was successfully applied to data sets from healthy volunteers and from patients with various lung diseases. The parameter maps demonstrated a more homogeneous distribution of p{sub A}O{sub 2} for the volunteers than for the patients. A regional increase in p{sub A}O{sub 2} was found in a few patients. Conclusion: the described software allows the absolute quantification of p{sub A}O{sub 2} as well as its variation over time. In the future therefore, the software may gain importance for detecting mis-matches between ventilation and perfusion, e.g., in patients with pulmonary embolism or chronic obstructive lung diseases. (orig.)

  12. Hidden Second-order Stationary Spatial Point Processes

    DEFF Research Database (Denmark)

    Hahn, Ute; Jensen, Eva B. Vedel

    2016-01-01

    In the existing statistical literature, the almost default choice for inference on inhomogeneous point processes is the most well-known model class for inhomogeneous point processes: reweighted second-order stationary processes. In particular, the K-function related to this type of inhomogeneity ....... Using the new theoretical framework, we reanalyse three inhomogeneous point patterns that have earlier been analysed in the statistical literature and show that the conclusions concerning an appropriate model class must be revised for some of the point patterns.......In the existing statistical literature, the almost default choice for inference on inhomogeneous point processes is the most well-known model class for inhomogeneous point processes: reweighted second-order stationary processes. In particular, the K-function related to this type of inhomogeneity...

  13. Investigating Clinically and Scientifically Useful Cut Points on the Compulsive Sexual Behavior Inventory.

    Science.gov (United States)

    Miner, Michael H; Raymond, Nancy; Coleman, Eli; Swinburne Romine, Rebecca

    2017-05-01

    One of the major obstacles to conducting epidemiologic research and determining the incidence and prevalence of compulsive sexual behavior (CSB) has been the lack of relevant empirically derived cut points on the various instruments that have been used to measure the concept. To further develop the Compulsive Sexual Behavior Inventory (CSBI) through exploring predictive validity and developing an empirically determined and clinically useful cut point for defining CSB. A sample of 242 men who have sex with men was recruited from various sites in a moderate-size Midwestern city. Participants were assigned to a CSB group or a control group using an interview for the diagnosis that was patterned after the Structured Clinical Interview for the Diagnostic and Statistical Manual for Mental Disorders, Fourth Edition. The 22-item CSBI was administered as part of a larger battery of self-report inventories. Receiver operating characteristic analyses were used to compute area-under-the-curve measurements to ascertain the predictive validity of the total scale, the control subscale, and the violence subscale. Cut points were determined through consensus of experts balancing sensitivity and specificity as determined by receiver operating characteristic curves. Analyses indicated that the 22-item CSBI was a good predictor of group membership, as was the 13-item control subscale. The violence subscale added little to the predictive accuracy of the instrument; thus, it likely measures something other than CSB. Two relevant cut points were found, one that minimized false negatives and another, more conservative cut point that minimized false positives. The CSBI as currently configured measures two different constructions and only the control subscale is helpful in diagnosing CSB. Therefore, we decided to eliminate the violence subscale and move forward with a 13-item scale that we have named the CSBI-13. Two cut points were developed from this revised scale, one that is useful as a

  14. Used Fuel Management System Interface Analyses - 13578

    Energy Technology Data Exchange (ETDEWEB)

    Howard, Robert; Busch, Ingrid [Oak Ridge National Laboratory, P.O. Box 2008, Bldg. 5700, MS-6170, Oak Ridge, TN 37831 (United States); Nutt, Mark; Morris, Edgar; Puig, Francesc [Argonne National Laboratory (United States); Carter, Joe; Delley, Alexcia; Rodwell, Phillip [Savannah River National Laboratory (United States); Hardin, Ernest; Kalinina, Elena [Sandia National Laboratories (United States); Clark, Robert [U.S. Department of Energy (United States); Cotton, Thomas [Complex Systems Group (United States)

    2013-07-01

    Preliminary system-level analyses of the interfaces between at-reactor used fuel management, consolidated storage facilities, and disposal facilities, along with the development of supporting logistics simulation tools, have been initiated to provide the U.S. Department of Energy (DOE) and other stakeholders with information regarding the various alternatives for managing used nuclear fuel (UNF) generated by the current fleet of light water reactors operating in the United States. An important UNF management system interface consideration is the need for ultimate disposal of UNF assemblies contained in waste packages that are sized to be compatible with different geologic media. Thermal analyses indicate that waste package sizes for the geologic media under consideration by the Used Fuel Disposition Campaign may be significantly smaller than the canisters being used for on-site dry storage by the nuclear utilities. Therefore, at some point along the UNF disposition pathway, there could be a need to repackage fuel assemblies already loaded and being loaded into the dry storage canisters currently in use. The implications of where and when the packaging or repackaging of commercial UNF will occur are key questions being addressed in this evaluation. The analysis demonstrated that thermal considerations will have a major impact on the operation of the system and that acceptance priority, rates, and facility start dates have significant system implications. (authors)

  15. Autisme et douleur – analyse bibliographique

    Science.gov (United States)

    Dubois, Amandine; Rattaz, Cécile; Pry, René; Baghdadli, Amaria

    2010-01-01

    La présente analyse bibliographique a pour objectif de réaliser un bilan des travaux publiés dans le champ de la douleur et de l’autisme. L’article aborde, dans un premier temps, les études publiées concernant les modes d’expression de la douleur observés dans cette population. Différentes hypothèses permettant d’expliquer les particularités expressives des personnes avec autisme sont ensuite passées en revue : excès d’endorphines, particularités dans le traitement sensoriel, déficit sociocommunicatif. Cette analyse bibliographique aborde, pour terminer, la question de l’évaluation et de la prise en compte de la douleur chez les personnes avec autisme. Les auteurs concluent à l’absence d’homogénéité des résultats des études publiées et au besoin de poursuivre les recherches afin de parvenir à des données consensuelles sur un domaine d’étude encore peu exploité au plan scientifique. Sur un plan clinique, l’approfondissement des connaissances dans ce domaine devrait permettre de mettre au point des outils d’évaluation de la douleur et d’ainsi en assurer une meilleure prise en charge au quotidien. PMID:20808970

  16. Myofascial Trigger Point Pain Syndromes.

    Science.gov (United States)

    Gerwin, Robert D

    2016-10-01

    Myofascial pain syndromes caused by trigger points (TrPs) in muscle are a common cause of local and generalized pain. Trigger points are hyperirritable zones in contracted bands of muscle, thought to be caused by muscle overload or stress. Stress TrPs have characteristic electromyographic features, and can be visualized with ultrasound and magnetic resonance elastography. Trigger point needling or injection can be effective in inactivating TrP, but correcting triggers is also critical. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

  17. NOTE: Do acupuncture points exist?

    Science.gov (United States)

    Yan, Xiaohui; Zhang, Xinyi; Liu, Chenglin; Dang, Ruishan; Huang, Yuying; He, Wei; Ding, Guanghong

    2009-05-01

    We used synchrotron x-ray fluorescence analysis to probe the distribution of four chemical elements in and around acupuncture points, two located in the forearm and two in the lower leg. Three of the four acupuncture points showed significantly elevated concentrations of elements Ca, Fe, Cu and Zn in relation to levels in the surrounding tissue, with similar elevation ratios for Cu and Fe. The mapped distribution of these elements implies that each acupuncture point seems to be elliptical with the long axis along the meridian.

  18. PowerPoint 2013 bible

    CERN Document Server

    Wempen, Faithe

    2013-01-01

    Master PowerPoint and improve your presentation skills with one book! In today's business climate, you need to know PowerPoint inside and out, and that's not all. You also need to be able to make a presentation that makes an impact. From using sophisticated transitions and animation in your PowerPoint presentations to interfacing in person with your audience, this information-packed book helps you succeed. Start creating professional-quality slides that captivate audiences and discover essential tips and techniques for making first-rate presentations, whether you're at a podium or

  19. Calorimetry end-point predictions

    International Nuclear Information System (INIS)

    Fox, M.A.

    1981-01-01

    This paper describes a portion of the work presently in progress at Rocky Flats in the field of calorimetry. In particular, calorimetry end-point predictions are outlined. The problems associated with end-point predictions and the progress made in overcoming these obstacles are discussed. The two major problems, noise and an accurate description of the heat function, are dealt with to obtain the most accurate results. Data are taken from an actual calorimeter and are processed by means of three different noise reduction techniques. The processed data are then utilized by one to four algorithms, depending on the accuracy desired to determined the end-point

  20. Hacking point of sale payment application secrets, threats, and solutions

    CERN Document Server

    Gomzin, Slava

    2014-01-01

    Must-have guide for professionals responsible for securing credit and debit card transactions As recent breaches like Target and Neiman Marcus show, payment card information is involved in more security breaches than any other data type. In too many places, sensitive card data is simply not protected adequately. Hacking Point of Sale is a compelling book that tackles this enormous problem head-on. Exploring all aspects of the problem in detail - from how attacks are structured to the structure of magnetic strips to point-to-point encryption, and more - it's packed with practical recommendati