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Sample records for point-spread functions psfs

  1. Synthesis of atmospheric turbulence point spread functions by sparse and redundant representations

    Science.gov (United States)

    Hunt, Bobby R.; Iler, Amber L.; Bailey, Christopher A.; Rucci, Michael A.

    2018-02-01

    Atmospheric turbulence is a fundamental problem in imaging through long slant ranges, horizontal-range paths, or uplooking astronomical cases through the atmosphere. An essential characterization of atmospheric turbulence is the point spread function (PSF). Turbulence images can be simulated to study basic questions, such as image quality and image restoration, by synthesizing PSFs of desired properties. In this paper, we report on a method to synthesize PSFs of atmospheric turbulence. The method uses recent developments in sparse and redundant representations. From a training set of measured atmospheric PSFs, we construct a dictionary of "basis functions" that characterize the atmospheric turbulence PSFs. A PSF can be synthesized from this dictionary by a properly weighted combination of dictionary elements. We disclose an algorithm to synthesize PSFs from the dictionary. The algorithm can synthesize PSFs in three orders of magnitude less computing time than conventional wave optics propagation methods. The resulting PSFs are also shown to be statistically representative of the turbulence conditions that were used to construct the dictionary.

  2. POINT-SPREAD FUNCTIONS FOR THE EXTREME-ULTRAVIOLET CHANNELS OF SDO/AIA TELESCOPES

    International Nuclear Information System (INIS)

    Poduval, B.; DeForest, C. E.; Schmelz, J. T.; Pathak, S.

    2013-01-01

    We present the stray-light point-spread functions (PSFs) and their inverses we characterized for the Atmospheric Imaging Assembly (AIA) EUV telescopes on board the Solar Dynamics Observatory (SDO) spacecraft. The inverse kernels are approximate inverses under convolution. Convolving the original Level 1 images with them produces images with improved stray-light characteristics. We demonstrate the usefulness of these PSFs by applying them to two specific cases: photometry and differential emission measure (DEM) analysis. The PSFs consist of a narrow Gaussian core, a diffraction component, and a diffuse component represented by the sum of a Gaussian-truncated Lorentzian and a shoulder Gaussian. We determined the diffraction term using the measured geometry of the diffraction pattern identified in flare images and the theoretically computed intensities of the principal maxima of the first few diffraction orders. To determine the diffuse component, we fitted its parameterized model using iterative forward-modeling of the lunar interior in the SDO/AIA images from the 2011 March 4 lunar transit. We find that deconvolution significantly improves the contrast in dark features such as miniature coronal holes, though the effect was marginal in bright features. On a percentage-scattering basis, the PSFs for SDO/AIA are better by a factor of two than that of the EUV telescope on board the Transition Region And Coronal Explorer mission. A preliminary analysis suggests that deconvolution alone does not affect DEM analysis of small coronal loop segments with suitable background subtraction. We include the derived PSFs and their inverses as supplementary digital materials.

  3. POINT-SPREAD FUNCTIONS FOR THE EXTREME-ULTRAVIOLET CHANNELS OF SDO/AIA TELESCOPES

    Energy Technology Data Exchange (ETDEWEB)

    Poduval, B.; DeForest, C. E. [Southwest Research Institute, 1050 Walnut Street, Suite 300, Boulder, CO 80302 (United States); Schmelz, J. T.; Pathak, S., E-mail: bala@boulder.swri.edu [Physics Department, University of Memphis, Memphis, TN 38152 (United States)

    2013-03-10

    We present the stray-light point-spread functions (PSFs) and their inverses we characterized for the Atmospheric Imaging Assembly (AIA) EUV telescopes on board the Solar Dynamics Observatory (SDO) spacecraft. The inverse kernels are approximate inverses under convolution. Convolving the original Level 1 images with them produces images with improved stray-light characteristics. We demonstrate the usefulness of these PSFs by applying them to two specific cases: photometry and differential emission measure (DEM) analysis. The PSFs consist of a narrow Gaussian core, a diffraction component, and a diffuse component represented by the sum of a Gaussian-truncated Lorentzian and a shoulder Gaussian. We determined the diffraction term using the measured geometry of the diffraction pattern identified in flare images and the theoretically computed intensities of the principal maxima of the first few diffraction orders. To determine the diffuse component, we fitted its parameterized model using iterative forward-modeling of the lunar interior in the SDO/AIA images from the 2011 March 4 lunar transit. We find that deconvolution significantly improves the contrast in dark features such as miniature coronal holes, though the effect was marginal in bright features. On a percentage-scattering basis, the PSFs for SDO/AIA are better by a factor of two than that of the EUV telescope on board the Transition Region And Coronal Explorer mission. A preliminary analysis suggests that deconvolution alone does not affect DEM analysis of small coronal loop segments with suitable background subtraction. We include the derived PSFs and their inverses as supplementary digital materials.

  4. Computation of the lateral and axial point spread functions in ...

    Indian Academy of Sciences (India)

    and ρ is the radial coordinate in the aperture plane (u, v). 2.2.1 Computation of the transverse APSF and its irradiance. The amplitude impulse response of the considered aperture or the amplitude point spread function (APSF) is computed by operating the Fourier transform upon the aperture represented by eq. (8) to obtain ...

  5. Point-spread function in depleted and partially depleted CCDs

    International Nuclear Information System (INIS)

    Groom, D.E.; Eberhard, P.H.; Holland, S.E.; Levi, M.E.; Palaio, N.P.; Perlmutter, S.; Stover, R.J.; Wei, M.

    1999-01-01

    The point spread function obtainable in an astronomical instrument using CCD readout is limited by a number of factors, among them the lateral diffusion of charge before it is collected in the potential wells. They study this problem both theoretically and experimentally, with emphasis on the thick CCDs on high-resistivity n-type substrates being developed at Lawrence Berkeley National Laboratory

  6. Modeling of EUV photoresists with a resist point spread function

    International Nuclear Information System (INIS)

    Cain, Jason P.; Naulleau, Patrick; Spanos, Costas J.

    2005-01-01

    Extreme ultraviolet (EUV) lithography is under development for possible deployment at the 32-nm technology node. One active area of research in this field is the development of photoresists that can meet the stringent requirements (high resolution, high sensitivity, low LER, etc.) of lithography in this regime. In order to facilitate research in this and other areas related to EUV lithography, a printing station based upon the 0.3-NA Micro Exposure Tool (MET) optic was established at the Advanced Light Source, a synchrotron facility at Lawrence Berkeley National Laboratory. A resist modeling technique using a resist point spread function has been shown to have good agreement with experiments for certain EUV resists such as Shipley EUV-2D [2]. The resist point spread function is a two-dimensional function that, when convolved with the simulated aerial image for a given mask pattern and applied to a threshold function, gives a representation of the photoresist pattern remaining after development. The simplicity of this modeling approach makes it attractive for rapid modeling of photoresists for process development applications. In this work, the resist point spread functions for three current high-resolution EUV photoresists [Rohm and Haas EUV-2D, Rohm and Haas MET-1K (XP 3454C), and KRS] are extracted experimentally. This model is then used in combination with aerial image simulations (including effects of projection optic aberrations) to predict the resist pattern for a variety of test patterns. A comparison is made between these predictions and experimental results to evaluate the effectiveness of this modeling technique for newer high-resolution EUV resists

  7. Point spread functions and deconvolution of ultrasonic images.

    Science.gov (United States)

    Dalitz, Christoph; Pohle-Fröhlich, Regina; Michalk, Thorsten

    2015-03-01

    This article investigates the restoration of ultrasonic pulse-echo C-scan images by means of deconvolution with a point spread function (PSF). The deconvolution concept from linear system theory (LST) is linked to the wave equation formulation of the imaging process, and an analytic formula for the PSF of planar transducers is derived. For this analytic expression, different numerical and analytic approximation schemes for evaluating the PSF are presented. By comparing simulated images with measured C-scan images, we demonstrate that the assumptions of LST in combination with our formula for the PSF are a good model for the pulse-echo imaging process. To reconstruct the object from a C-scan image, we compare different deconvolution schemes: the Wiener filter, the ForWaRD algorithm, and the Richardson-Lucy algorithm. The best results are obtained with the Richardson-Lucy algorithm with total variation regularization. For distances greater or equal twice the near field distance, our experiments show that the numerically computed PSF can be replaced with a simple closed analytic term based on a far field approximation.

  8. Point spread functions of the T2 decay in k-space trajectories with long echo train.

    Science.gov (United States)

    Qin, Qin

    2012-10-01

    T(2) decay during long echo trains of magnetic resonance (MR) imaging pulse sequences is known to cause a blurring effect, due to the peak broadening of the point spread function (PSF). In contrast, the simultaneous amplitude-loss effect, led by the peak reduction of the PSF, has gained much less attention. In this report, we analyzed the PSFs of both the truncation and T(2) decay for Cartesian (linear profile ordering and low-high ordering) and spiral trajectories, respectively. Then, we derived simple formulas to characterize both the blurring and amplitude-loss effects, which are functions of the ratios of the echo train duration (T(k)) over T(2) (T(k)/T(2)). Signal-to-noise ratio (SNR) per unit time was thus analyzed considering both the amplitude-loss effect induced by the T(2) decay and the SNR gain from the long acquisition duration based on MR sampling theory. Optimum T(k)/T(2) ratios to achieve maximum SNR per unit time were 1.2 for the Cartesian trajectory and 0.8 for the spiral trajectory. Copyright © 2012 Elsevier Inc. All rights reserved.

  9. Design of mobile phone lens with extended depth of field based on point-spread function focus invariance

    Science.gov (United States)

    Sung, Hsin-Yueh; Yang, Sidney S.; Chang, Horng

    2008-08-01

    Due to the application of mobile phone lens, the clear image for the different object distance from infinity to close-up creates a new bargaining. We found that wave-front coding applied to extend the depth of field may solve this problem. By means of using cubic phase mask (CPM), the blurred point-spread function (PSF) is substantially invariant to defocus. Thus, the ideal hyperfocal distance condition can be satisfied as long as the constant blurred image can eventually be recovered by a simple digital signal processing. In this paper, we propose a different design method of computational imaging lens for mobile phone up to ideal depth of field based on PSF focus invariance. Because of the difficulty for comparing the similarity to different PSFs, we define a new metric, of correlation, to evaluate and optimize the PSF similarity. Besides, by means of adding the anti-symmetric free form phase plate at aperture stop and using the correlation and Strehl ratio as the two major optimization operands, we can get the optimum phase plate surface to achieve the required extended depth of field (EDoF). The resulted PSF on focal plane is significantly invariant to object distance varying from infinity to 10cm.

  10. Aberrations of the point spread function of a multimode fiber due to partial mode excitation

    NARCIS (Netherlands)

    Descloux, Adrien; Amitonova, Lyubov; Pinkse, Pepijn Willemszoon Harry

    2016-01-01

    We investigate the point spread function of a multimode fiber. The distortion of the focal spot created on the fiber output facet is studied for a variety of the parameters. We develop a theoretical model of wavefront shaping through a multimode fiber and use it to confirm our experimental results

  11. Point-spread functions for backscattered imaging in the scanning electron microscope

    Science.gov (United States)

    Hennig, Philipp; Denk, Winfried

    2007-12-01

    One knows the imaging system's properties are central to the correct interpretation of any image. In a scanning electron microscope regions of different composition generally interact in a highly nonlinear way during signal generation. Using Monte Carlo simulations we found that in resin-embedded, heavy metal-stained biological specimens staining is sufficiently dilute to allow an approximately linear treatment. We then mapped point-spread functions for backscattered-electron contrast, for primary energies of 3 and 7 keV and for different detector specifications. The point-spread functions are surprisingly well confined (both laterally and in depth) compared even to the distribution of only those scattered electrons that leave the sample again.

  12. Quantitative electron tomography: The effect of the three-dimensional point spread function

    Energy Technology Data Exchange (ETDEWEB)

    Heidari, Hamed [EMAT, University of Antwerp, Groenenborgerlaan 171, B-2020 Antwerp (Belgium); Van den Broek, Wouter [Institut für Experimentelle Physik, Universität Ulm, Albert-Einstein-Allee 11, 89081 Ulm (Germany); Bals, Sara, E-mail: sara.bals@ua.ac.be [EMAT, University of Antwerp, Groenenborgerlaan 171, B-2020 Antwerp (Belgium)

    2013-12-15

    The intensity levels in a three-dimensional (3D) reconstruction, obtained by electron tomography, can be influenced by several experimental imperfections. Such artifacts will hamper a quantitative interpretation of the results. In this paper, we will correct for artificial intensity variations by determining the 3D point spread function (PSF) of a tomographic reconstruction based on high angle annular dark field scanning transmission electron microscopy. The large tails of the PSF cause an underestimation of the intensity of smaller particles, which in turn hampers an accurate radius estimate. Here, the error introduced by the PSF is quantified and corrected a posteriori. - Highlights: • Intensity variations in 3D reconstructions hamper quantification of tomography data. • These variations are corrected based on the point spread function. • The approach can be considered as an optimized route to 3D quantification.

  13. Deconvolution of the two-dimensional point-spread function of area detectors using the maximum-entropy algorithm

    NARCIS (Netherlands)

    Graafsma, H; de Vries, R.Y.

    1999-01-01

    The maximum-entropy method (MEM) has been applied for the deconvolution of the point-spread function (PSF) of two-dimensional X-ray detectors. The method is robust, model and image independent, and only depends on the correct description of the two-dimensional point-spread function and gain factor

  14. Quantitative electron tomography: the effect of the three-dimensional point spread function.

    Science.gov (United States)

    Heidari, Hamed; Van den Broek, Wouter; Bals, Sara

    2013-12-01

    The intensity levels in a three-dimensional (3D) reconstruction, obtained by electron tomography, can be influenced by several experimental imperfections. Such artifacts will hamper a quantitative interpretation of the results. In this paper, we will correct for artificial intensity variations by determining the 3D point spread function (PSF) of a tomographic reconstruction based on high angle annular dark field scanning transmission electron microscopy. The large tails of the PSF cause an underestimation of the intensity of smaller particles, which in turn hampers an accurate radius estimate. Here, the error introduced by the PSF is quantified and corrected a posteriori. Copyright © 2013 Elsevier B.V. All rights reserved.

  15. Aberrations of the point spread function of a multimode fiber due to partial mode excitation

    Science.gov (United States)

    Descloux, Adrien; Amitonova, Lyubov V.; Pinkse, Pepijn W. H.

    2016-08-01

    We investigate the point spread function of a multimode fiber. The distortion of the focal spot created on the fiber output facet is studied for a variety of the parameters. We develop a theoretical model of wavefront shaping through a multimode fiber and use it to confirm our experimental results and analyze the nature of the focal distortions. We show that aberration-free imaging with a large field of view can be achieved by using an appropriate number of segments on the spatial light modulator during the wavefront-shaping procedure. The results describe aberration limits for imaging with multimode fibers as in, e.g., microendoscopy.

  16. Estimation Methods of the Point Spread Function Axial Position: A Comparative Computational Study

    Directory of Open Access Journals (Sweden)

    Javier Eduardo Diaz Zamboni

    2017-01-01

    Full Text Available The precise knowledge of the point spread function is central for any imaging system characterization. In fluorescence microscopy, point spread function (PSF determination has become a common and obligatory task for each new experimental device, mainly due to its strong dependence on acquisition conditions. During the last decade, algorithms have been developed for the precise calculation of the PSF, which fit model parameters that describe image formation on the microscope to experimental data. In order to contribute to this subject, a comparative study of three parameter estimation methods is reported, namely: I-divergence minimization (MIDIV, maximum likelihood (ML and non-linear least square (LSQR. They were applied to the estimation of the point source position on the optical axis, using a physical model. Methods’ performance was evaluated under different conditions and noise levels using synthetic images and considering success percentage, iteration number, computation time, accuracy and precision. The main results showed that the axial position estimation requires a high SNR to achieve an acceptable success level and higher still to be close to the estimation error lower bound. ML achieved a higher success percentage at lower SNR compared to MIDIV and LSQR with an intrinsic noise source. Only the ML and MIDIV methods achieved the error lower bound, but only with data belonging to the optical axis and high SNR. Extrinsic noise sources worsened the success percentage, but no difference was found between noise sources for the same method for all methods studied.

  17. Fast and accurate three-dimensional point spread function computation for fluorescence microscopy.

    Science.gov (United States)

    Li, Jizhou; Xue, Feng; Blu, Thierry

    2017-06-01

    The point spread function (PSF) plays a fundamental role in fluorescence microscopy. A realistic and accurately calculated PSF model can significantly improve the performance in 3D deconvolution microscopy and also the localization accuracy in single-molecule microscopy. In this work, we propose a fast and accurate approximation of the Gibson-Lanni model, which has been shown to represent the PSF suitably under a variety of imaging conditions. We express the Kirchhoff's integral in this model as a linear combination of rescaled Bessel functions, thus providing an integral-free way for the calculation. The explicit approximation error in terms of parameters is given numerically. Experiments demonstrate that the proposed approach results in a significantly smaller computational time compared with current state-of-the-art techniques to achieve the same accuracy. This approach can also be extended to other microscopy PSF models.

  18. Point-spread function in ghost imaging system with thermal light.

    Science.gov (United States)

    Gao, Yang; Bai, Yanfeng; Fu, Xiquan

    2016-10-31

    The point-spread function (PSF) is fundamental importance in estimating the imaging resolution in optical imaging systems. By using the Collins formula, a analytical imaging formula for ghost imaging system is obtained. The intensity fluctuation correlation function can be viewed as the convolution of the original object and a PSF. The imaging resolution is determined by the width of PSF. Based on the optical transfer matrix theory, we present the analytical formula describing the width of the PSF, by which one can estimate imaging resolution of a new-designed imaging scheme when compared with that of the existing imaging system. Several typical ghost imaging systems are chosen to verify experimentally our theoretical results.

  19. Point-spread functions of a polarizing microscope equipped with high-numerical-aperture lenses.

    Science.gov (United States)

    Oldenbourg, R; Török, P

    2000-12-01

    In an effort to establish the imaging properties of a new type of polarized-light microscope, we recorded images of small, uniaxial, birefringent crystals. We show that the sequence of in-focus and out-of-focus images, the so-called point-spread function, of a submicroscopic crystal can be used to measure the orientation of its optic axis in three-dimensional space. By analogy to conoscopic images out-of-focus images reveal the changes in relative phase shift between the extraordinary and the ordinary rays that propagate at different directions through the crystal. We also present simulated images of a pointlike anisotropic scattering particle and compare these with our experimental findings. The theoretical model is based on a complete vectorial theory for partial coherent imaging by use of polarized light and high-numerical-aperture lenses.

  20. Plasmon point spread functions: How do we model plasmon-mediated emission processes?

    Science.gov (United States)

    Willets, Katherine A.

    2014-02-01

    A major challenge with studying plasmon-mediated emission events is the small size of plasmonic nanoparticles relative to the wavelength of light. Objects smaller than roughly half the wavelength of light will appear as diffraction-limited spots in far-field optical images, presenting a significant experimental challenge for studying plasmonic processes on the nanoscale. Super-resolution imaging has recently been applied to plasmonic nanosystems and allows plasmon-mediated emission to be resolved on the order of ˜5 nm. In super-resolution imaging, a diffraction-limited spot is fit to some model function in order to calculate the position of the emission centroid, which represents the location of the emitter. However, the accuracy of the centroid position strongly depends on how well the fitting function describes the data. This Perspective discusses the commonly used two-dimensional Gaussian fitting function applied to super-resolution imaging of plasmon-mediated emission, then introduces an alternative model based on dipole point spread functions. The two fitting models are compared and contrasted for super-resolution imaging of nanoparticle scattering/luminescence, surface-enhanced Raman scattering, and surface-enhanced fluorescence.

  1. Reconstruction of Kelvin probe force microscopy image with experimentally calibrated point spread function.

    Science.gov (United States)

    Lan, Fei; Jiang, Minlin; Tao, Quan; Wei, Fanan; Li, Guangyong

    2017-03-01

    A Kelvin probe force microscopy (KPFM) image is sometimes difficult to interpret because it is a blurred representation of the true surface potential (SP) distribution of the materials under test. The reason for the blurring is that KPFM relies on the detection of electrostatic force, which is a long-range force compared to other surface forces. Usually, KPFM imaging model is described as the convolution of the true SP distribution of the sample with an intrinsic point spread function (PSF) of the measurement system. To restore the true SP signals from the blurred ones, the intrinsic PSF of the system is needed. In this work, we present a way to experimentally calibrate the PSF of the KPFM system. Taking the actual probe shape and experimental parameters into consideration, this calibration method leads to a more accurate PSF than the ones obtained from simulations. Moreover, a nonlinear reconstruction algorithm based on total variation (TV) regularization is applied to KPFM measurement to reverse the blurring caused by PSF during KPFM imaging process; as a result, noises are reduced and the fidelity of SP signals is improved.

  2. Point Spread Function (PSF) noise filter strategy for geiger mode LiDAR

    Science.gov (United States)

    Smith, O'Neil; Stark, Robert; Smith, Philip; St. Romain, Randall; Blask, Steven

    2013-05-01

    LiDAR is an efficient optical remote sensing technology that has application in geography, forestry, and defense. The effectiveness is often limited by signal-to-noise ratio (SNR). Geiger mode avalanche photodiode (APD) detectors are able to operate above critical voltage, and a single photoelectron can initiate the current surge, making the device very sensitive. These advantages come at the expense of requiring computationally intensive noise filtering techniques. Noise is a problem which affects the imaging system and reduces the capability. Common noise-reduction algorithms have drawbacks such as over aggressive filtering, or decimating in order to improve quality and performance. In recent years, there has been growing interest on GPUs (Graphics Processing Units) for their ability to perform powerful massive parallel processing. In this paper, we leverage this capability to reduce the processing latency. The Point Spread Function (PSF) filter algorithm is a local spatial measure that has been GPGPU accelerated. The idea is to use a kernel density estimation technique for point clustering. We associate a local likelihood measure with every point of the input data capturing the probability that a 3D point is true target-return photons or noise (background photons, dark-current). This process suppresses noise and allows for detection of outliers. We apply this approach to the LiDAR noise filtering problem for which we have recognized a speed-up factor of 30-50 times compared to traditional sequential CPU implementation.

  3. Extended Nijboer-Zernike approach for the computation of optical point-spread functions.

    Science.gov (United States)

    Janssen, Augustus J E M

    2002-05-01

    New Bessel-series representations for the calculation of the diffraction integral are presented yielding the point-spread function of the optical system, as occurs in the Nijboer-Zernike theory of aberrations. In this analysis one can allow an arbitrary aberration and a defocus part. The representations are presented in full detail for the cases of coma and astigmatism. The analysis leads to stably converging results in the case of large aberration or defocus values, while the applicability of the original Nijboer-Zernike theory is limited mainly to wave-front deviations well below the value of one wavelength. Because of its intrinsic speed, the analysis is well suited to supplement or to replace numerical calculations that are currently used in the fields of (scanning) microscopy, lithography, and astronomy. In a companion paper [J. Opt. Soc. Am. A 19, 860 (2002)], physical interpretations and applications in a lithographic context are presented, a convergence analysis is given, and a comparison is made with results obtained by using a numerical package.

  4. Point spread function modeling and image restoration for cone-beam CT

    International Nuclear Information System (INIS)

    Zhang Hua; Shi Yikai; Huang Kuidong; Xu Zhe

    2015-01-01

    X-ray cone-beam computed tomography (CT) has such notable features as high efficiency and precision, and is widely used in the fields of medical imaging and industrial non-destructive testing, but the inherent imaging degradation reduces the quality of CT images. Aimed at the problems of projection image degradation and restoration in cone-beam CT, a point spread function (PSF) modeling method is proposed first. The general PSF model of cone-beam CT is established, and based on it, the PSF under arbitrary scanning conditions can be calculated directly for projection image restoration without the additional measurement, which greatly improved the application convenience of cone-beam CT. Secondly, a projection image restoration algorithm based on pre-filtering and pre-segmentation is proposed, which can make the edge contours in projection images and slice images clearer after restoration, and control the noise in the equivalent level to the original images. Finally, the experiments verified the feasibility and effectiveness of the proposed methods. (authors)

  5. Projections onto Convex Sets Super-Resolution Reconstruction Based on Point Spread Function Estimation of Low-Resolution Remote Sensing Images.

    Science.gov (United States)

    Fan, Chong; Wu, Chaoyun; Li, Grand; Ma, Jun

    2017-02-13

    To solve the problem on inaccuracy when estimating the point spread function (PSF) of the ideal original image in traditional projection onto convex set (POCS) super-resolution (SR) reconstruction, this paper presents an improved POCS SR algorithm based on PSF estimation of low-resolution (LR) remote sensing images. The proposed algorithm can improve the spatial resolution of the image and benefit agricultural crop visual interpolation. The PSF of the highresolution (HR) image is unknown in reality. Therefore, analysis of the relationship between the PSF of the HR image and the PSF of the LR image is important to estimate the PSF of the HR image by using multiple LR images. In this study, the linear relationship between the PSFs of the HR and LR images can be proven. In addition, the novel slant knife-edge method is employed, which can improve the accuracy of the PSF estimation of LR images. Finally, the proposed method is applied to reconstruct airborne digital sensor 40 (ADS40) three-line array images and the overlapped areas of two adjacent GF-2 images by embedding the estimated PSF of the HR image to the original POCS SR algorithm. Experimental results show that the proposed method yields higher quality of reconstructed images than that produced by the blind SR method and the bicubic interpolation method.

  6. Projections onto Convex Sets Super-Resolution Reconstruction Based on Point Spread Function Estimation of Low-Resolution Remote Sensing Images

    Directory of Open Access Journals (Sweden)

    Chong Fan

    2017-02-01

    Full Text Available To solve the problem on inaccuracy when estimating the point spread function (PSF of the ideal original image in traditional projection onto convex set (POCS super-resolution (SR reconstruction, this paper presents an improved POCS SR algorithm based on PSF estimation of low-resolution (LR remote sensing images. The proposed algorithm can improve the spatial resolution of the image and benefit agricultural crop visual interpolation. The PSF of the highresolution (HR image is unknown in reality. Therefore, analysis of the relationship between the PSF of the HR image and the PSF of the LR image is important to estimate the PSF of the HR image by using multiple LR images. In this study, the linear relationship between the PSFs of the HR and LR images can be proven. In addition, the novel slant knife-edge method is employed, which can improve the accuracy of the PSF estimation of LR images. Finally, the proposed method is applied to reconstruct airborne digital sensor 40 (ADS40 three-line array images and the overlapped areas of two adjacent GF-2 images by embedding the estimated PSF of the HR image to the original POCS SR algorithm. Experimental results show that the proposed method yields higher quality of reconstructed images than that produced by the blind SR method and the bicubic interpolation method.

  7. The point spread function of the human head and its implications for transcranial current stimulation

    International Nuclear Information System (INIS)

    Dmochowski, Jacek P; Bikson, Marom; Parra, Lucas C

    2012-01-01

    Rational development of transcranial current stimulation (tCS) requires solving the ‘forward problem’: the computation of the electric field distribution in the head resulting from the application of scalp currents. Derivation of forward models has represented a major effort in brain stimulation research, with model complexity ranging from spherical shells to individualized head models based on magnetic resonance imagery. Despite such effort, an easily accessible benchmark head model is greatly needed when individualized modeling is either undesired (to observe general population trends as opposed to individual differences) or unfeasible. Here, we derive a closed-form linear system which relates the applied current to the induced electric potential. It is shown that in the spherical harmonic (Fourier) domain, a simple scalar multiplication relates the current density on the scalp to the electric potential in the brain. Equivalently, the current density in the head follows as the spherical convolution between the scalp current distribution and the point spread function of the head, which we derive. Thus, if one knows the spherical harmonic representation of the scalp current (i.e. the electrode locations and current intensity to be employed), one can easily compute the resulting electric field at any point inside the head. Conversely, one may also readily determine the scalp current distribution required to generate an arbitrary electric field in the brain (the ‘backward problem’ in tCS). We demonstrate the simplicity and utility of the model with a series of characteristic curves which sweep across a variety of stimulation parameters: electrode size, depth of stimulation, head size and anode–cathode separation. Finally, theoretically optimal montages for targeting an infinitesimal point in the brain are shown. (paper)

  8. Influence of Signal-to-Noise Ratio and Point Spread Function on Limits of Super-Resolution

    NARCIS (Netherlands)

    Pham, T.Q.; Vliet, L.J. van; Schutte, K.

    2005-01-01

    This paper presents a method to predict the limit of possible resolution enhancement given a sequence of low resolution images. Three important parameters influence the outcome of this limit: the total Point Spread Function (PSF), the Signal-to-Noise Ratio (SNR) and the number of input images.

  9. Influence of signal-to-noise ratio and point spread function on limits of super-resolution

    NARCIS (Netherlands)

    Pham, T.Q.; Van Vliet, L.; Schutte, K.

    2005-01-01

    This paper presents a method to predict the limit of possible resolution enhancement given a sequence of lowresolution images. Three important parameters influence the outcome of this limit: the total Point Spread Function (PSF), the Signal-to-Noise Ratio (SNR) and the number of input images.

  10. On the complex three-dimensional amplitude point spread function of lenses and microscope objectives: theoretical aspects, simulations and measurements by digital holography.

    Science.gov (United States)

    Marian, A; Charrière, F; Colomb, T; Montfort, F; Kühn, J; Marquet, P; Depeursinge, C

    2007-02-01

    The point spread function is widely used to characterize the three-dimensional imaging capabilities of an optical system. Usually, attention is paid only to the intensity point spread function, whereas the phase point spread function is most often neglected because the phase information is not retrieved in noninterferometric imaging systems. However, phase point spread functions are needed to evaluate phase-sensitive imaging systems and we believe that phase data can play an essential role in the full aberrations' characterization. In this paper, standard diffraction models have been used for the computation of the complex amplitude point spread function. In particular, the Debye vectorial model has been used to compute the amplitude point spread function of x63/0.85 and x100/1.3 microscope objectives, exemplifying the phase point spread function specific for each polarization component of the electromagnetic field. The effect of aberrations on the phase point spread function is then analyzed for a microscope objective used under nondesigned conditions, by developing the Gibson model (Gibson & Lanni, 1991), modified to compute the three-dimensional amplitude point spread function in amplitude and phase. The results have revealed a novel anomalous phase behaviour in the presence of spherical aberration, providing access to the quantification of the aberrations. This work mainly proposes a method to measure the complex three-dimensional amplitude point spread function of an optical imaging system. The approach consists in measuring and interpreting the amplitude point spread function by evaluating in amplitude and phase the image of a single emitting point, a 60-nm-diameter tip of a Near Field Scanning Optical Microscopy fibre, with an original digital holographic experimental setup. A single hologram gives access to the transverse amplitude point spread function. The three-dimensional amplitude point spread function is obtained by performing an axial scan of the

  11. Assessment of an extended Nijboer-Zernike approach for the computation of optical point-spread functions.

    Science.gov (United States)

    Braat, Joseph; Dirksen, Peter; Janssen, Augustus J E M

    2002-05-01

    We assess the validity of an extended Nijboer-Zernike approach [J. Opt. Soc. Am. A 19, 849 (2002)], based on ecently found Bessel-series representations of diffraction integrals comprising an arbitrary aberration and a defocus part, for the computation of optical point-spread functions of circular, aberrated optical systems. These new series representations yield a flexible means to compute optical point-spread functions, both accurately and efficiently, under defocus and aberration conditions that seem to cover almost all cases of practical interest. Because of the analytical nature of the formulas, there are no discretization effects limiting the accuracy, as opposed to the more commonly used numerical packages based on strictly numerical integration methods. Instead, we have an easily managed criterion, expressed in the number of terms to be included in the Bessel-series representations, guaranteeing the desired accuracy. For this reason, the analytical method can also serve as a calibration tool for the numerically based methods. The analysis is not limited to pointlike objects but can also be used for extended objects under various illumination conditions. The calculation schemes are simple and permit one to trace the relative strength of the various interfering complex-amplitude terms that contribute to the final image intensity function.

  12. Three-Dimensional Super-Resolution in Eukaryotic Cells Using the Double-Helix Point Spread Function.

    Science.gov (United States)

    Carr, Alexander R; Ponjavic, Aleks; Basu, Srinjan; McColl, James; Santos, Ana Mafalda; Davis, Simon; Laue, Ernest D; Klenerman, David; Lee, Steven F

    2017-04-11

    Single-molecule localization microscopy, typically based on total internal reflection illumination, has taken our understanding of protein organization and dynamics in cells beyond the diffraction limit. However, biological systems exist in a complicated three-dimensional environment, which has required the development of new techniques, including the double-helix point spread function (DHPSF), to accurately visualize biological processes. The application of the DHPSF approach has so far been limited to the study of relatively small prokaryotic cells. By matching the refractive index of the objective lens immersion liquid to that of the sample media, we demonstrate DHPSF imaging of up to 15-μm-thick whole eukaryotic cell volumes in three to five imaging planes. We illustrate the capabilities of the DHPSF by exploring large-scale membrane reorganization in human T cells after receptor triggering, and by using single-particle tracking to image several mammalian proteins, including membrane, cytoplasmic, and nuclear proteins in T cells and embryonic stem cells. Crown Copyright © 2017. Published by Elsevier Inc. All rights reserved.

  13. Analysis of point source size on measurement accuracy of lateral point-spread function of confocal Raman microscopy

    Science.gov (United States)

    Fu, Shihang; Zhang, Li; Hu, Yao; Ding, Xiang

    2018-01-01

    Confocal Raman Microscopy (CRM) has matured to become one of the most powerful instruments in analytical science because of its molecular sensitivity and high spatial resolution. Compared with conventional Raman Microscopy, CRM can perform three dimensions mapping of tiny samples and has the advantage of high spatial resolution thanking to the unique pinhole. With the wide application of the instrument, there is a growing requirement for the evaluation of the imaging performance of the system. Point-spread function (PSF) is an important approach to the evaluation of imaging capability of an optical instrument. Among a variety of measurement methods of PSF, the point source method has been widely used because it is easy to operate and the measurement results are approximate to the true PSF. In the point source method, the point source size has a significant impact on the final measurement accuracy. In this paper, the influence of the point source sizes on the measurement accuracy of PSF is analyzed and verified experimentally. A theoretical model of the lateral PSF for CRM is established and the effect of point source size on full-width at half maximum of lateral PSF is simulated. For long-term preservation and measurement convenience, PSF measurement phantom using polydimethylsiloxane resin, doped with different sizes of polystyrene microspheres is designed. The PSF of CRM with different sizes of microspheres are measured and the results are compared with the simulation results. The results provide a guide for measuring the PSF of the CRM.

  14. Distortion correction of echo planar images applying the concept of finite rate of innovation to point spread function mapping (FRIP).

    Science.gov (United States)

    Nunes, Rita G; Hajnal, Joseph V

    2018-01-03

    Point spread function (PSF) mapping enables estimating the displacement fields required for distortion correction of echo planar images. Recently, a highly accelerated approach was introduced for estimating displacements from the phase slope of under-sampled PSF mapping data. Sampling schemes with varying spacing were proposed requiring stepwise phase unwrapping. To avoid unwrapping errors, an alternative approach applying the concept of finite rate of innovation to PSF mapping (FRIP) is introduced, using a pattern search strategy to locate the PSF peak, and the two methods are compared. Fully sampled PSF data was acquired in six subjects at 3.0 T, and distortion maps were estimated after retrospective under-sampling. The two methods were compared for both previously published and newly optimized sampling patterns. Prospectively under-sampled data were also acquired. Shift maps were estimated and deviations relative to the fully sampled reference map were calculated. The best performance was achieved when using FRIP with a previously proposed sampling scheme. The two methods were comparable for the remaining schemes. The displacement field errors tended to be lower as the number of samples or their spacing increased. A robust method for estimating the position of the PSF peak has been introduced.

  15. Bayesian penalized-likelihood reconstruction algorithm suppresses edge artifacts in PET reconstruction based on point-spread-function.

    Science.gov (United States)

    Yamaguchi, Shotaro; Wagatsuma, Kei; Miwa, Kenta; Ishii, Kenji; Inoue, Kazumasa; Fukushi, Masahiro

    2018-03-01

    The Bayesian penalized-likelihood reconstruction algorithm (BPL), Q.Clear, uses relative difference penalty as a regularization function to control image noise and the degree of edge-preservation in PET images. The present study aimed to determine the effects of suppression on edge artifacts due to point-spread-function (PSF) correction using a Q.Clear. Spheres of a cylindrical phantom contained a background of 5.3 kBq/mL of [ 18 F]FDG and sphere-to-background ratios (SBR) of 16, 8, 4 and 2. The background also contained water and spheres containing 21.2 kBq/mL of [ 18 F]FDG as non-background. All data were acquired using a Discovery PET/CT 710 and were reconstructed using three-dimensional ordered-subset expectation maximization with time-of-flight (TOF) and PSF correction (3D-OSEM), and Q.Clear with TOF (BPL). We investigated β-values of 200-800 using BPL. The PET images were analyzed using visual assessment and profile curves, edge variability and contrast recovery coefficients were measured. The 38- and 27-mm spheres were surrounded by higher radioactivity concentration when reconstructed with 3D-OSEM as opposed to BPL, which suppressed edge artifacts. Images of 10-mm spheres had sharper overshoot at high SBR and non-background when reconstructed with BPL. Although contrast recovery coefficients of 10-mm spheres in BPL decreased as a function of increasing β, higher penalty parameter decreased the overshoot. BPL is a feasible method for the suppression of edge artifacts of PSF correction, although this depends on SBR and sphere size. Overshoot associated with BPL caused overestimation in small spheres at high SBR. Higher penalty parameter in BPL can suppress overshoot more effectively. Copyright © 2018 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.

  16. Improved image quality in pinhole SPECT by accurate modeling of the point spread function in low magnification systems

    International Nuclear Information System (INIS)

    Pino, Francisco; Roé, Nuria; Aguiar, Pablo; Falcon, Carles; Ros, Domènec; Pavía, Javier

    2015-01-01

    Purpose: Single photon emission computed tomography (SPECT) has become an important noninvasive imaging technique in small-animal research. Due to the high resolution required in small-animal SPECT systems, the spatially variant system response needs to be included in the reconstruction algorithm. Accurate modeling of the system response should result in a major improvement in the quality of reconstructed images. The aim of this study was to quantitatively assess the impact that an accurate modeling of spatially variant collimator/detector response has on image-quality parameters, using a low magnification SPECT system equipped with a pinhole collimator and a small gamma camera. Methods: Three methods were used to model the point spread function (PSF). For the first, only the geometrical pinhole aperture was included in the PSF. For the second, the septal penetration through the pinhole collimator was added. In the third method, the measured intrinsic detector response was incorporated. Tomographic spatial resolution was evaluated and contrast, recovery coefficients, contrast-to-noise ratio, and noise were quantified using a custom-built NEMA NU 4–2008 image-quality phantom. Results: A high correlation was found between the experimental data corresponding to intrinsic detector response and the fitted values obtained by means of an asymmetric Gaussian distribution. For all PSF models, resolution improved as the distance from the point source to the center of the field of view increased and when the acquisition radius diminished. An improvement of resolution was observed after a minimum of five iterations when the PSF modeling included more corrections. Contrast, recovery coefficients, and contrast-to-noise ratio were better for the same level of noise in the image when more accurate models were included. Ring-type artifacts were observed when the number of iterations exceeded 12. Conclusions: Accurate modeling of the PSF improves resolution, contrast, and recovery

  17. Improved image quality in pinhole SPECT by accurate modeling of the point spread function in low magnification systems

    Energy Technology Data Exchange (ETDEWEB)

    Pino, Francisco [Unitat de Biofísica, Facultat de Medicina, Universitat de Barcelona, Barcelona 08036, Spain and Servei de Física Mèdica i Protecció Radiològica, Institut Català d’Oncologia, L’Hospitalet de Llobregat 08907 (Spain); Roé, Nuria [Unitat de Biofísica, Facultat de Medicina, Universitat de Barcelona, Barcelona 08036 (Spain); Aguiar, Pablo, E-mail: pablo.aguiar.fernandez@sergas.es [Fundación Ramón Domínguez, Complexo Hospitalario Universitario de Santiago de Compostela 15706, Spain and Grupo de Imagen Molecular, Instituto de Investigacións Sanitarias de Santiago de Compostela (IDIS), Galicia 15782 (Spain); Falcon, Carles; Ros, Domènec [Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona 08036, Spain and CIBER en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Barcelona 08036 (Spain); Pavía, Javier [Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona 080836 (Spain); CIBER en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Barcelona 08036 (Spain); and Servei de Medicina Nuclear, Hospital Clínic, Barcelona 08036 (Spain)

    2015-02-15

    Purpose: Single photon emission computed tomography (SPECT) has become an important noninvasive imaging technique in small-animal research. Due to the high resolution required in small-animal SPECT systems, the spatially variant system response needs to be included in the reconstruction algorithm. Accurate modeling of the system response should result in a major improvement in the quality of reconstructed images. The aim of this study was to quantitatively assess the impact that an accurate modeling of spatially variant collimator/detector response has on image-quality parameters, using a low magnification SPECT system equipped with a pinhole collimator and a small gamma camera. Methods: Three methods were used to model the point spread function (PSF). For the first, only the geometrical pinhole aperture was included in the PSF. For the second, the septal penetration through the pinhole collimator was added. In the third method, the measured intrinsic detector response was incorporated. Tomographic spatial resolution was evaluated and contrast, recovery coefficients, contrast-to-noise ratio, and noise were quantified using a custom-built NEMA NU 4–2008 image-quality phantom. Results: A high correlation was found between the experimental data corresponding to intrinsic detector response and the fitted values obtained by means of an asymmetric Gaussian distribution. For all PSF models, resolution improved as the distance from the point source to the center of the field of view increased and when the acquisition radius diminished. An improvement of resolution was observed after a minimum of five iterations when the PSF modeling included more corrections. Contrast, recovery coefficients, and contrast-to-noise ratio were better for the same level of noise in the image when more accurate models were included. Ring-type artifacts were observed when the number of iterations exceeded 12. Conclusions: Accurate modeling of the PSF improves resolution, contrast, and recovery

  18. Simulating PSFs for WFIRST and JWST with WebbPSF

    Science.gov (United States)

    Long, Joseph D.; Perrin, Marshall D.; Van Der Marel, Roeland P.

    2016-01-01

    Accurate models of a telescope's point spread function are key to predicting its performance and extracting information from observations. Developed at STScI since 2010, WebbPSF is a flexible Python-based PSF simulation tool initially developed for JWST's imaging, spectroscopy, and coronagraphic instruments. We present improvements that allow this tool to simulate PSFs for the WFIRST wide-field imaging mode, as well as additional spectroscopy modes for the NIRSpec, MIRI, and NIRISS instruments on JWST. The WFIRST wide field imaging mode is also the first WebbPSF model to simulate PSF variation across the entire field of view. These variations are included in the Fraunhofer-domain PSF calculation as Zernike polynomial terms up to Z22. As WFIRST is still early in its development, high-spatial-frequency wavefront errors (beyond Z22) are incorporated using an optical path difference map from another notable 2.4 meter space telescope. Common infrastructure to build simulated optical instruments has been made available as POPPY (Physical Optics Propagation in Python), an open-source library that has seen contributions from users in astronomy and beyond.

  19. DETERMINATION OF THE POINT-SPREAD FUNCTION FOR THE FERMI LARGE AREA TELESCOPE FROM ON-ORBIT DATA AND LIMITS ON PAIR HALOS OF ACTIVE GALACTIC NUCLEI

    Energy Technology Data Exchange (ETDEWEB)

    Ackermann, M. [Deutsches Elektronen Synchrotron DESY, D-15738 Zeuthen (Germany); Ajello, M.; Allafort, A.; Bechtol, K.; Bloom, E. D.; Borgland, A. W.; Bottacini, E.; Buehler, R. [W. W. Hansen Experimental Physics Laboratory, Kavli Institute for Particle Astrophysics and Cosmology, Department of Physics and SLAC National Accelerator Laboratory, Stanford University, Stanford, CA 94305 (United States); Asano, K. [Interactive Research Center of Science, Tokyo Institute of Technology, Meguro City, Tokyo 152-8551 (Japan); Atwood, W. B. [Santa Cruz Institute for Particle Physics, Department of Physics and Department of Astronomy and Astrophysics, University of California at Santa Cruz, Santa Cruz, CA 95064 (United States); Baldini, L.; Bellazzini, R.; Bregeon, J. [Istituto Nazionale di Fisica Nucleare, Sezione di Pisa, I-56127 Pisa (Italy); Ballet, J. [Laboratoire AIM, CEA-IRFU/CNRS/Universite Paris Diderot, Service d' Astrophysique, CEA Saclay, F-91191 Gif sur Yvette (France); Barbiellini, G. [Istituto Nazionale di Fisica Nucleare, Sezione di Trieste, I-34127 Trieste (Italy); Bastieri, D. [Istituto Nazionale di Fisica Nucleare, Sezione di Padova, I-35131 Padova (Italy); Bonamente, E. [Istituto Nazionale di Fisica Nucleare, Sezione di Perugia, I-06123 Perugia (Italy); Brandt, T. J. [CNRS, IRAP, F-31028 Toulouse cedex 4 (France); Brigida, M. [Dipartimento di Fisica ' M. Merlin' dell' Universita e del Politecnico di Bari, I-70126 Bari (Italy); Bruel, P., E-mail: mdwood@slac.stanford.edu, E-mail: mar0@uw.edu [Laboratoire Leprince-Ringuet, Ecole polytechnique, CNRS/IN2P3, F-91128 Palaiseau (France); and others

    2013-03-01

    The Large Area Telescope (LAT) on the Fermi Gamma-ray Space Telescope is a pair-conversion telescope designed to detect photons with energies from Almost-Equal-To 20 MeV to >300 GeV. The pre-launch response functions of the LAT were determined through extensive Monte Carlo simulations and beam tests. The point-spread function (PSF) characterizing the angular distribution of reconstructed photons as a function of energy and geometry in the detector is determined here from two years of on-orbit data by examining the distributions of {gamma} rays from pulsars and active galactic nuclei (AGNs). Above 3 GeV, the PSF is found to be broader than the pre-launch PSF. We checked for dependence of the PSF on the class of {gamma}-ray source and observation epoch and found none. We also investigated several possible spatial models for pair-halo emission around BL Lac AGNs. We found no evidence for a component with spatial extension larger than the PSF and set upper limits on the amplitude of halo emission in stacked images of low- and high-redshift BL Lac AGNs and the TeV blazars 1ES0229+200 and 1ES0347-121.

  20. Impact of point spread function correction in standardized uptake value quantitation for positron emission tomography images. A study based on phantom experiments and clinical images

    International Nuclear Information System (INIS)

    Nakamura, Akihiro; Tanizaki, Yasuo; Takeuchi, Miho

    2014-01-01

    While point spread function (PSF)-based positron emission tomography (PET) reconstruction effectively improves the spatial resolution and image quality of PET, it may damage its quantitative properties by producing edge artifacts, or Gibbs artifacts, which appear to cause overestimation of regional radioactivity concentration. In this report, we investigated how edge artifacts produce negative effects on the quantitative properties of PET. Experiments with a National Electrical Manufacturers Association (NEMA) phantom, containing radioactive spheres of a variety of sizes and background filled with cold air or water, or radioactive solutions, showed that profiles modified by edge artifacts were reproducible regardless of background μ values, and the effects of edge artifacts increased with increasing sphere-to-background radioactivity concentration ratio (S/B ratio). Profiles were also affected by edge artifacts in complex fashion in response to variable combinations of sphere sizes and S/B ratios; and central single-peak overestimation up to 50% was occasionally noted in relatively small spheres with high S/B ratios. Effects of edge artifacts were obscured in spheres with low S/B ratios. In patient images with a variety of focal lesions, areas of higher radioactivity accumulation were generally more enhanced by edge artifacts, but the effects were variable depending on the size of and accumulation in the lesion. PET images generated using PSF-based reconstruction are therefore not appropriate for the evaluation of SUV. (author)

  1. The M 4 Core Project with HST - V. Characterizing the PSFs of WFC3/UVIS by focus★

    Science.gov (United States)

    Anderson, J.; Bedin, L. R.

    2017-09-01

    As part of the astrometric Hubble Space Telescope (HST) large program GO-12911, we conduct an in-depth study to characterize the point spread function (PSF) of the Uv-VISual channel of the Wide Field Camera 3 (WFC3), as a necessary step to achieve the astrometric goals of the program. We extracted a PSF from each of the 589 deep exposures taken through the F467M filter over the course of a year and find that the vast majority of the PSFs lie along a 1-D locus that stretches continuously from one side of focus, through optimal focus, to the other side of focus. We constructed a focus-diverse set of PSFs and find that with only five medium-bright stars in an exposure it is possible to pin down the focus level of that exposure. We show that the focus-optimized PSF does a considerably better job fitting stars than the average 'library' PSF, especially when the PSF is out of focus. The fluxes and positions are significantly improved over the 'library' PSF treatment. These results are beneficial for a much broader range of scientific applications than simply the program at hand, but the immediate use of these PSFs will enable us to search for astrometric wobble in the bright stars in the core of the globular cluster M 4, which would indicate a dark, high-mass companion, such as a white dwarf, neutron star or black hole.

  2. SU-G-IeP3-08: Image Reconstruction for Scanning Imaging System Based On Shape-Modulated Point Spreading Function

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Ruixing; Yang, LV [College of Optoelectronic Science and Engineering, National University of Defense Technology, Changsha, Hunan (China); Xu, Kele [College of Electronical Science and Engineering, National University of Defense Technology, Changsha, Hunan (China); Zhu, Li [Institute of Electrostatic and Electromagnetic Protection, Mechanical Engineering College, Shijiazhuang, Hebei (China)

    2016-06-15

    Purpose: Deconvolution is a widely used tool in the field of image reconstruction algorithm when the linear imaging system has been blurred by the imperfect system transfer function. However, due to the nature of Gaussian-liked distribution for point spread function (PSF), the components with coherent high frequency in the image are hard to restored in most of the previous scanning imaging system, even the relatively accurate PSF is acquired. We propose a novel method for deconvolution of images which are obtained by using shape-modulated PSF. Methods: We use two different types of PSF - Gaussian shape and donut shape - to convolute the original image in order to simulate the process of scanning imaging. By employing deconvolution of the two images with corresponding given priors, the image quality of the deblurred images are compared. Then we find the critical size of the donut shape compared with the Gaussian shape which has similar deconvolution results. Through calculation of tightened focusing process using radially polarized beam, such size of donut is achievable under same conditions. Results: The effects of different relative size of donut and Gaussian shapes are investigated. When the full width at half maximum (FWHM) ratio of donut and Gaussian shape is set about 1.83, similar resolution results are obtained through our deconvolution method. Decreasing the size of donut will favor the deconvolution method. A mask with both amplitude and phase modulation is used to create a donut-shaped PSF compared with the non-modulated Gaussian PSF. Donut with size smaller than our critical value is obtained. Conclusion: The utility of donutshaped PSF are proved useful and achievable in the imaging and deconvolution processing, which is expected to have potential practical applications in high resolution imaging for biological samples.

  3. Clinical evaluation of whole-body oncologic PET with time-of-flight and point-spread function for the hybrid PET/MR system.

    Science.gov (United States)

    Shang, Kun; Cui, Bixiao; Ma, Jie; Shuai, Dongmei; Liang, Zhigang; Jansen, Floris; Zhou, Yun; Lu, Jie; Zhao, Guoguang

    2017-08-01

    Hybrid positron emission tomography/magnetic resonance (PET/MR) imaging is a new multimodality imaging technology that can provide structural and functional information simultaneously. The aim of this study was to investigate the effects of the time-of-flight (TOF) and point-spread function (PSF) on small lesions observed in PET/MR images from clinical patient image sets. This study evaluated 54 small lesions in 14 patients who had undergone 18 F-fluorodeoxyglucose (FDG) PET/MR. Lesions up to 30mm in diameter were included. The PET data were reconstructed with a baseline ordered-subsets expectation-maximization (OSEM) algorithm, OSEM+PSF, OSEM+TOF and OSEM+TOF+PSF. PET image quality and small lesions were visually evaluated and scored by a 3-point scale. A quantitative analysis was then performed using the mean and maximum standardized uptake value (SUV) of the small lesions (SUV mean and SUV max ). The lesions were divided into two groups according to the long-axis diameter and the location respectively and evaluated with each reconstruction algorithm. We also evaluated the background signal by analyzing the SUV liver . OSEM+TOF+PSF provided the highest value and OSEM+TOF or PSF showed a higher value than OSEM for the visual assessment and quantitative analysis. The combination of TOF and PSF increased the SUV mean by 26.6% and the SUV max by 30.0%. The SUV liver was not influenced by PSF or TOF. For the OSEM+TOF+PSF model, the change in SUV mean and SUV max for lesions PET/MR images, potentially improving small lesion detectability. Copyright © 2017 Elsevier B.V. All rights reserved.

  4. X-ray beam-shaping via deformable mirrors: surface profile and point spread function computation for Gaussian beams using physical optics.

    Science.gov (United States)

    Spiga, D

    2018-01-01

    X-ray mirrors with high focusing performances are commonly used in different sectors of science, such as X-ray astronomy, medical imaging and synchrotron/free-electron laser beamlines. While deformations of the mirror profile may cause degradation of the focus sharpness, a deliberate deformation of the mirror can be made to endow the focus with a desired size and distribution, via piezo actuators. The resulting profile can be characterized with suitable metrology tools and correlated with the expected optical quality via a wavefront propagation code or, sometimes, predicted using geometric optics. In the latter case and for the special class of profile deformations with monotonically increasing derivative, i.e. concave upwards, the point spread function (PSF) can even be predicted analytically. Moreover, under these assumptions, the relation can also be reversed: from the desired PSF the required profile deformation can be computed analytically, avoiding the use of trial-and-error search codes. However, the computation has been so far limited to geometric optics, which entailed some limitations: for example, mirror diffraction effects and the size of the coherent X-ray source were not considered. In this paper, the beam-shaping formalism in the framework of physical optics is reviewed, in the limit of small light wavelengths and in the case of Gaussian intensity wavefronts. Some examples of shaped profiles are also shown, aiming at turning a Gaussian intensity distribution into a top-hat one, and checks of the shaping performances computing the at-wavelength PSF by means of the WISE code are made.

  5. Evaluation of spatial dependence of point spread function-based PET reconstruction using a traceable point-like 22Na source

    Directory of Open Access Journals (Sweden)

    Taisuke Murata

    2016-10-01

    Full Text Available Abstract Background The point spread function (PSF of positron emission tomography (PET depends on the position across the field of view (FOV. Reconstruction based on PSF improves spatial resolution and quantitative accuracy. The present study aimed to quantify the effects of PSF correction as a function of the position of a traceable point-like 22Na source over the FOV on two PET scanners with a different detector design. Methods We used Discovery 600 and Discovery 710 (GE Healthcare PET scanners and traceable point-like 22Na sources (<1 MBq with a spherical absorber design that assures uniform angular distribution of the emitted annihilation photons. The source was moved in three directions at intervals of 1 cm from the center towards the peripheral FOV using a three-dimensional (3D-positioning robot, and data were acquired over a period of 2 min per point. The PET data were reconstructed by filtered back projection (FBP, the ordered subset expectation maximization (OSEM, OSEM + PSF, and OSEM + PSF + time-of-flight (TOF. Full width at half maximum (FWHM was determined according to the NEMA method, and total counts in regions of interest (ROI for each reconstruction were quantified. Results The radial FWHM of FBP and OSEM increased towards the peripheral FOV, whereas PSF-based reconstruction recovered the FWHM at all points in the FOV of both scanners. The radial FWHM for PSF was 30–50 % lower than that of OSEM at the center of the FOV. The accuracy of PSF correction was independent of detector design. Quantitative values were stable across the FOV in all reconstruction methods. The effect of TOF on spatial resolution and quantitation accuracy was less noticeable. Conclusions The traceable 22Na point-like source allowed the evaluation of spatial resolution and quantitative accuracy across the FOV using different reconstruction methods and scanners. PSF-based reconstruction reduces dependence of the spatial resolution on the

  6. Evaluation of the Effect of Tumor Position on Standardized Uptake Value Using Time-of-Flight Reconstruction and Point Spread Function

    Directory of Open Access Journals (Sweden)

    Yasuharu Wakabayashi

    2016-01-01

    Full Text Available Objective(s: The present study was conducted to examine whether the standardized uptake value (SUV may be affected by the spatial position of a lesion in the radial direction on positron emission tomography (PET images, obtained via two methods based on time-of-flight (TOF reconstruction and point spread function (PSF. Methods: A cylinder phantom with the sphere (30mm diameter, located in the center was used in this study. Fluorine-18 fluorodeoxyglucose (18F-FDG concentrations of 5.3 kBq/ml and 21.2 kBq/ml were used for the background in the cylinder phantom and the central sphere respectively. By the use of TOF and PSF, SUVmax and SUVmean were determined while moving the phantom in a horizontal direction (X direction from the center of field of view (FOV: 0 mm at 50, 100, 150 and 200 mm positions, respectively. Furthermore, we examined 41 patients (23 male, 18 female, mean age: 68±11.2 years with lymph node tumors , who had undergone 18F-FDG PET examinations. The distance of each lymph node from FOV center was measured, based on the clinical images. Results: As the distance of a lesion from the FOV center exceeded 100 mm, the value of SUVmax, which was obtained with the cylinder phantom, was overestimated, while SUVmean by TOF and/or PSF was underestimated. Based on the clinical examinations, the average volume of interest was 8.5 cm3. Concomitant use of PSF increased SUVmax and SUVmean by 27.9% and 2.8%, respectively. However, size of VOI and distance from the FOV center did not affect SUVmax or SUVmean in clinical examinations. Conclusion: The reliability of SUV quantification by TOF and/or PSF decreased, when the tumor was located at a 100 mm distance (or farther from the center of FOV. In clinical examinations, if the lymph node was located within 100 mm distance from the center of FOV, SUV remained stable within a constantly increasing range by use of both TOF and PSF. We conclude that, use of both TOF and PSF may be helpful.

  7. The edge artifact in the point-spread function-based PET reconstruction at different sphere-to-background ratios of radioactivity.

    Science.gov (United States)

    Kidera, Daisuke; Kihara, Ken; Akamatsu, Go; Mikasa, Shohei; Taniguchi, Takafumi; Tsutsui, Yuji; Takeshita, Toshiki; Maebatake, Akira; Miwa, Kenta; Sasaki, Masayuki

    2016-02-01

    The aim of this study was to quantitatively evaluate the edge artifacts in PET images reconstructed using the point-spread function (PSF) algorithm at different sphere-to-background ratios of radioactivity (SBRs). We used a NEMA IEC body phantom consisting of six spheres with 37, 28, 22, 17, 13 and 10 mm in inner diameter. The background was filled with (18)F solution with a radioactivity concentration of 2.65 kBq/mL. We prepared three sets of phantoms with SBRs of 16, 8, 4 and 2. The PET data were acquired for 20 min using a Biograph mCT scanner. The images were reconstructed with the baseline ordered subsets expectation maximization (OSEM) algorithm, and with the OSEM + PSF correction model (PSF). For the image reconstruction, the number of iterations ranged from one to 10. The phantom PET image analyses were performed by a visual assessment of the PET images and profiles, a contrast recovery coefficient (CRC), which is the ratio of SBR in the images to the true SBR, and the percent change in the maximum count between the OSEM and PSF images (Δ % counts). In the PSF images, the spheres with a diameter of 17 mm or larger were surrounded by a dense edge in comparison with the OSEM images. In the spheres with a diameter of 22 mm or smaller, an overshoot appeared in the center of the spheres as a sharp peak in the PSF images in low SBR. These edge artifacts were clearly observed in relation to the increase of the SBR. The overestimation of the CRC was observed in 13 mm spheres in the PSF images. In the spheres with a diameter of 17 mm or smaller, the Δ % counts increased with an increasing SBR. The Δ % counts increased to 91 % in the 10-mm sphere at the SBR of 16. The edge artifacts in the PET images reconstructed using the PSF algorithm increased with an increasing SBR. In the small spheres, the edge artifact was observed as a sharp peak at the center of spheres and could result in overestimation.

  8. A new signal restoration method based on deconvolution of the Point Spread Function (PSF) for the Flat-Field Holographic Concave Grating UV spectrometer system

    Science.gov (United States)

    Dai, Honglin; Luo, Yongdao

    2013-12-01

    In recent years, with the development of the Flat-Field Holographic Concave Grating, they are adopted by all kinds of UV spectrometers. By means of single optical surface, the Flat-Field Holographic Concave Grating can implement dispersion and imaging that make the UV spectrometer system design quite compact. However, the calibration of the Flat-Field Holographic Concave Grating is very difficult. Various factors make its imaging quality difficult to be guaranteed. So we have to process the spectrum signal with signal restoration before using it. Guiding by the theory of signals and systems, and after a series of experiments, we found that our UV spectrometer system is a Linear Space- Variant System. It means that we have to measure PSF of every pixel of the system which contains thousands of pixels. Obviously, that's a large amount of calculation .For dealing with this problem, we proposes a novel signal restoration method. This method divides the system into several Linear Space-Invariant subsystems and then makes signal restoration with PSFs. Our experiments turn out that this method is effective and inexpensive.

  9. Multi-kernel deconvolution for contrast improvement in a full field imaging system with engineered PSFs using conical diffraction

    Science.gov (United States)

    Enguita, Jose M.; Álvarez, Ignacio; González, Rafael C.; Cancelas, Jose A.

    2018-01-01

    The problem of restoration of a high-resolution image from several degraded versions of the same scene (deconvolution) has been receiving attention in the last years in fields such as optics and computer vision. Deconvolution methods are usually based on sets of images taken with small (sub-pixel) displacements or slightly different focus. Techniques based on sets of images obtained with different point-spread-functions (PSFs) engineered by an optical system are less popular and mostly restricted to microscopic systems, where a spot of light is projected onto the sample under investigation, which is then scanned point-by-point. In this paper, we use the effect of conical diffraction to shape the PSFs in a full-field macroscopic imaging system. We describe a series of simulations and real experiments that help to evaluate the possibilities of the system, showing the enhancement in image contrast even at frequencies that are strongly filtered by the lens transfer function or when sampling near the Nyquist frequency. Although results are preliminary and there is room to optimize the prototype, the idea shows promise to overcome the limitations of the image sensor technology in many fields, such as forensics, medical, satellite, or scientific imaging.

  10. EPOXI INFLIGHT CALIBRATIONS - HRIV STELLAR PSFS V1.0

    Data.gov (United States)

    National Aeronautics and Space Administration — This data set contains a clear-filtered High Resolution Visible CCD (HRIV) point spread function (PSF) for exoplanet transit targets GJ 436, HAT-P-4, HAT-P-7,...

  11. Intensity-dependent point spread image processing

    International Nuclear Information System (INIS)

    Cornsweet, T.N.; Yellott, J.I.

    1984-01-01

    There is ample anatomical, physiological and psychophysical evidence that the mammilian retina contains networks that mediate interactions among neighboring receptors, resulting in intersecting transformations between input images and their corresponding neural output patterns. The almost universally accepted view is that the principal form of interaction involves lateral inhibition, resulting in an output pattern that is the convolution of the input with a ''Mexican hat'' or difference-of-Gaussians spread function, having a positive center and a negative surround. A closely related process is widely applied in digital image processing, and in photography as ''unsharp masking''. The authors show that a simple and fundamentally different process, involving no inhibitory or subtractive terms can also account for the physiological and psychophysical findings that have been attributed to lateral inhibition. This process also results in a number of fundamental effects that occur in mammalian vision and that would be of considerable significance in robotic vision, but which cannot be explained by lateral inhibitory interaction

  12. Computation of the lateral and axial point spread functions in ...

    Indian Academy of Sciences (India)

    ... confocal scanning microscopes for the above-mentioned amplitude filters. These results of axial and lateral irradiances are graphically represented by constructing a computer program using MATLAB. The obtained results are compared with that obtained in case of circular, annular, and Martinez-Corral apodized aperture ...

  13. Computation of the lateral and axial point spread functions in ...

    Indian Academy of Sciences (India)

    scanning microscopes for the above-mentioned amplitude filters. These results of axial and lateral irradiances are graphically represented by constructing a computer program using MATLAB. The obtained results are compared with that obtained in case of circular, annular, and Martinez-Corral apodized aperture. Keywords ...

  14. Study on Performance Shaping Factors (PSFs) Quantification Method in Human Reliability Analysis (HRA)

    International Nuclear Information System (INIS)

    Kim, Ar Ryum; Jang, Inseok Jang; Seong, Poong Hyun; Park, Jinkyun; Kim, Jong Hyun

    2015-01-01

    The purpose of HRA implementation is 1) to achieve the human factor engineering (HFE) design goal of providing operator interfaces that will minimize personnel errors and 2) to conduct an integrated activity to support probabilistic risk assessment (PRA). For these purposes, various HRA methods have been developed such as technique for human error rate prediction (THERP), simplified plant analysis risk human reliability assessment (SPAR-H), cognitive reliability and error analysis method (CREAM) and so on. In performing HRA, such conditions that influence human performances have been represented via several context factors called performance shaping factors (PSFs). PSFs are aspects of the human's individual characteristics, environment, organization, or task that specifically decrements or improves human performance, thus respectively increasing or decreasing the likelihood of human errors. Most HRA methods evaluate the weightings of PSFs by expert judgment and explicit guidance for evaluating the weighting is not provided. It has been widely known that the performance of the human operator is one of the critical factors to determine the safe operation of NPPs. HRA methods have been developed to identify the possibility and mechanism of human errors. In performing HRA methods, the effect of PSFs which may increase or decrease human error should be investigated. However, the effect of PSFs were estimated by expert judgment so far. Accordingly, in order to estimate the effect of PSFs objectively, the quantitative framework to estimate PSFs by using PSF profiles is introduced in this paper

  15. An experimental investigation on relationship between PSFs and operator performances in the digital main control room

    International Nuclear Information System (INIS)

    Park, Jooyoung; Lee, Daeil; Jung, Wondea; Kim, Jonghyun

    2017-01-01

    Highlights: • The relationship between performance shaping factors and operator performances are experimentally investigated. • The experiment includes features of digital main control room. • The result indicates that the operator’s experience level is the most effective on the performance. - Abstract: This study designs an experiment to investigate the relationship between performance shaping factors (PSFs) and operator performances. This study involves selecting three PSFs that are controllable in the experiments: (1) experience, (2) complexity, and (3) urgency. Six scenarios are developed to reflect the PSFs. The experiment involves the participation of licensed operators and the use of an APR1400 simulator. During the experiment, operator performances, such as completion time, error, secondary task, workload, and situation awareness, are measured and collected. The experimental result indicates that the operator’s experience is most effective on the overall performances. The task complexity influences the secondary tasks and situation awareness.

  16. Human Error Probabilites (HEPs) for generic tasks and Performance Shaping Factors (PSFs) selected for railway operations

    DEFF Research Database (Denmark)

    Thommesen, Jacob; Andersen, Henning Boje

    at task level, which can be performed with fewer resources than a more detailed analysis of specific errors for each task. The generic tasks are presented with estimated Human Error Probabili-ties (HEPs) based on and extrapolated from the HRA literature, and estimates are compared with samples of measures......This report describes an HRA (Human Reliability Assessment) of six generic tasks and four Perfor-mance Shaping Factors (PSFs) targeted at railway operations commissioned by Banedanmark. The selection and characterization of generic tasks and PSFs are elaborated by DTU Management in close...... on estimates derived from industries other than rail and the general warning that a task-based analysis is less precise than an error-based one. The authors recommend that estimates be adjusted to actual measures of task failures when feasible....

  17. “Hot Hand” in the National Basketball Association Point Spread Betting Market: A 34-Year Analysis

    Directory of Open Access Journals (Sweden)

    Benjamin Waggoner

    2014-11-01

    Full Text Available Several articles have looked at factors that affect the adjustments of point spreads, based on hot hands or streaks, for smaller durations of time. This study examines these effects for 34 regular seasons in the National Basketball Association (NBA. Estimating a Seemingly Unrelated Regression model using all 34 seasons, all streaks significantly impacted point spreads and difference in actual points. When estimating each season individually, differences emerged particularly examining winning and losing streaks of six games or more. The results indicate both the presence of momentum effects and the gambler’s fallacy.

  18. Simultaneous Measurement of Air-water Interface Slope and the Point Spread Function for the Propagation of Laser Light

    National Research Council Canada - National Science Library

    Jaffe, Jules S

    2007-01-01

    The objective of this project funded by ONR (grant # N00014-06-1-0374) was to measure, understand and be able to predict the propagation of light through the air-sea interface under various sea states...

  19. The patient-specific functional scale: psychometrics, clinimetrics, and application as a clinical outcome measure.

    Science.gov (United States)

    Horn, Katyana Kowalchuk; Jennings, Sophie; Richardson, Gillian; Vliet, Ditte Van; Hefford, Cheryl; Abbott, J Haxby

    2012-01-01

    Systematic review of the literature. To summarize peer-reviewed literature on the reliability, validity, and responsiveness of the Patient-Specific Functional Scale (PSFS), and to identify its use as an outcome measure. Searches were performed of several electronic databases from 1995 to May 2010. Studies included were published articles containing (1) primary research investigating the psychometric and clinimetrics of the PSFS or (2) the implementation of the PSFS as an outcome measure. We assessed the methodological quality of studies included in the first category. Two hundred forty-two articles published from 1994 to May 2010 were identified. Of these, 66 met the inclusion criteria for this review, with 13 reporting the measurement properties of the PSFS, 55 implementing the PSFS as an outcome measure, and 2 doing both of the above. The PSFS was reported to be valid, reliable, and responsive in populations with knee dysfunction, cervical radiculopathy, acute low back pain, mechanical low back pain, and neck dysfunction. The PSFS was found to be reliable and responsive in populations with chronic low back pain. The PSFS was also reported to be valid, reliable, or responsive in individuals with a limited number of acute, subacute, and chronic conditions. This review found that the PSFS is also being used as an outcome measure in many other conditions, despite a lack of published evidence supporting its validity in these conditions. Although the use of the PSFS as an outcome measure is increasing in physiotherapy practice, there are gaps in the research literature regarding its validity, reliability, and responsiveness in many health conditions.

  20. The reliability and construct validity of the Neck Disability Index and patient specific functional scale in patients with cervical radiculopathy.

    Science.gov (United States)

    Cleland, Joshua A; Fritz, Julie M; Whitman, Julie M; Palmer, Jessica A

    2006-03-01

    Cohort study of patients with cervical radiculopathy undergoing physical therapy. Examine the test-retest reliability, construct validity, and minimum levels of detectable and clinically important change for the Neck Disability Index (NDI) and Patient Specific Functional Scale (PSFS) in cohort of patients with cervical radiculopathy. To date, no studies have investigated the psychometric properties of the NDI or PSFS in a cohort of patients with cervical radiculopathy. Thirty-eight patients with cervical radiculopathy undergoing physical therapy completed the NDI and PSFS, and Numerical Pain Rating Scale (NPRS) at the baseline examination and at a follow-up. In addition, at follow-up, patients completed a 15-point global rating of change (GROC), which was used to dichotomize patients as improved or stable. Changes in the NDI and PSFS were then used to assess test-retest reliability, construct validity, and minimal levels of detectable and clinically important change. Test-retest reliability was moderate for the NDI (intraclass correlation coefficient [ICC] = 0.68; 95% confidence interval [CI], 0.30-0.90) and high for the PSFS (ICC = 0.82; 95% CI, 0.54-0.93). The PSFS was more responsive to change than the NDI. The minimal detectable change for the NDI was 10.2 and for the PSFS 2.1. The minimally clinically important change for the NDI was 7.0 and PSFS 2.0. Our results suggest that the PSFS exhibits superior reliability, construct validity, and responsiveness in this cohort of patients with cervical radiculopathy compared with the NDI. Further research is needed to examine the ability of these measures to accurately reflect changes in individuals, as well as large samples of patients.

  1. Single scan parameterization of space-variant point spread functions in image space via a printed array: the impact for two PET/CT scanners

    Energy Technology Data Exchange (ETDEWEB)

    Kotasidis, F A; Matthews, J C; Angelis, G I; Noonan, P J; Jackson, A [Imaging, Genomics and Proteomics, Wolfson Molecular Imaging Centre, MAHSC, University of Manchester, Manchester (United Kingdom); Price, P [Academic Department of Radiation Oncology, University of Manchester, Manchester (United Kingdom); Lionheart, W R [School of Mathematics, Alan Turing Building, University of Manchester, Manchester (United Kingdom); Reader, A J, E-mail: fotis.kotasidis@mmic.man.ac.uk [Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC (Canada)

    2011-05-21

    Incorporation of a resolution model during statistical image reconstruction often produces images of improved resolution and signal-to-noise ratio. A novel and practical methodology to rapidly and accurately determine the overall emission and detection blurring component of the system matrix using a printed point source array within a custom-made Perspex phantom is presented. The array was scanned at different positions and orientations within the field of view (FOV) to examine the feasibility of extrapolating the measured point source blurring to other locations in the FOV and the robustness of measurements from a single point source array scan. We measured the spatially-variant image-based blurring on two PET/CT scanners, the B-Hi-Rez and the TruePoint TrueV. These measured spatially-variant kernels and the spatially-invariant kernel at the FOV centre were then incorporated within an ordinary Poisson ordered subset expectation maximization (OP-OSEM) algorithm and compared to the manufacturer's implementation using projection space resolution modelling (RM). Comparisons were based on a point source array, the NEMA IEC image quality phantom, the Cologne resolution phantom and two clinical studies (carbon-11 labelled anti-sense oligonucleotide [{sup 11}C]-ASO and fluorine-18 labelled fluoro-l-thymidine [{sup 18}F]-FLT). Robust and accurate measurements of spatially-variant image blurring were successfully obtained from a single scan. Spatially-variant resolution modelling resulted in notable resolution improvements away from the centre of the FOV. Comparison between spatially-variant image-space methods and the projection-space approach (the first such report, using a range of studies) demonstrated very similar performance with our image-based implementation producing slightly better contrast recovery (CR) for the same level of image roughness (IR). These results demonstrate that image-based resolution modelling within reconstruction is a valid alternative to projection-based modelling, and that, when using the proposed practical methodology, the necessary resolution measurements can be obtained from a single scan. This approach avoids the relatively time-consuming and involved procedures previously proposed in the literature.

  2. GEOTECNOLOGIA COMO SUPORTE PARA GERÊNCIA DE PSFs: UM ESTUDO DE CASO PARA O MUNICÍPIO DE VIÇOSA – MG

    Directory of Open Access Journals (Sweden)

    Taciano Oliveira da Silva

    2010-08-01

    Full Text Available Neste artigo abordou-se a aplicação da geotecnologia na área de saúde pública, a partir da elaboração de um banco de dados sobre as ocorrências de diarréias, dengue, diabetes e hipertensão, no município de Viçosa – MG. Os dados foram coletados nos postos de saúde da família (PSFs, no posto de combate a dengues e no setor de vigilância epidemiológica da secretaria municipal de saúde, e são referentes ao ano de 2007, com exceção para as ocorrências de diarréia que constam também os dados do ano de 2006. A geotecnologia, a partir do uso de equipamento GPS e de um sistema de informação geográfica (SIG, forneceu um suporte valioso para a análise e a compreensão do comportamento espacial das doenças analisadas. Este entendimento permitiu verificar os locais mais carentes de assistência de saúde preventiva. A geração de mapas auxiliará os agentes de saúde na localização das áreas de ocorrência dos eventos, otimizando o trabalho preventivo de saúde no município.

  3. Overview of experimental progress on understanding photon strength functions with an emphasis of the Oslo method

    Science.gov (United States)

    Krticka, Milan

    2015-10-01

    The so-called Photon Strength Functions (PSFs) for different multipolarities are, together with the Nuclear Level Density (NLD) the key entities describing the statistical γ-decay of nucleus. It is well known that PSFs at energies above the threshold for particle emission are well described by the Lorentzian shape of the Giant Electric Dipole Resonance (GEDR). On the other hand, shapes of RSFs at the low-energy tail of GEDR are known rather poorly. Information on the PSFs at the GEDR tail can be obtained from several different experimental techniques. They will be summarized and the most important ones briefly introduced in this contribution. Special emphasis will be put on the so-called Oslo method which allows simultaneous extraction of the NLD and the PSFs from particle- γ coincidence measurements. This method has been used for determining the NLD and the PSFs in many nuclei in A ~ 45- 240 range during past years. Examples of the most interesting results obtained with this method will be shown. The results will be compared to information on the PSFs available from other experimental techniques. The strengths and the weaknesses of the method will be thoroughly discussed.

  4. Imagery-derived modulation transfer function and its applications for underwater imaging

    Science.gov (United States)

    Hou, Weilin; Weidemann, Alan D.; Gray, Deric J.; Fournier, Georges R.

    2007-09-01

    The main challenge working with underwater imagery results from both rapid decay of signals due to absorption, which leads to poor signal to noise returns, and the blurring caused by strong scattering by the water itself and constituents within, especially particulates. The modulation transfer function (MTF) of an optical system gives the detailed and precise information regarding the system behavior. Underwater imageries can be better restored with the knowledge of the system MTF or the point spread function (PSF), the Fourier transformed equivalent, extending the performance range as well as the information retrieval from underwater electro-optical system. This is critical in many civilian and military applications, including target and especially mine detection, search and rescue, and diver visibility. This effort utilizes test imageries obtained by the Laser Underwater Camera Imaging Enhancer (LUCIE) from Defense Research and Development Canada (DRDC), during an April-May 2006 trial experiment in Panama City, Florida. Imaging of a standard resolution chart with various spatial frequencies were taken underwater in a controlled optical environment, at varying distances. In-water optical properties during the experiment were measured, which included the absorption and attenuation coefficients, particle size distribution, and volume scattering function. Resulting images were preprocessed to enhance signal to noise ratio by averaging multiple frames, and to remove uneven illumination at target plane. The MTF of the medium was then derived from measurement of above imageries, subtracting the effect of the camera system. PSFs converted from the measured MTF were then used to restore the blurred imageries by different deconvolution methods. The effects of polarization from source to receiver on resulting MTFs were examined and we demonstrate that matching polarizations do enhance system transfer functions. This approach also shows promise in deriving medium optical

  5. Multi-Functional Magnetic Photoluminescent Photocatalytic Polystyrene-Based Micro- and Nano-Fibers Obtained by Electrospinning

    Directory of Open Access Journals (Sweden)

    Michel Schaer

    2014-02-01

    Full Text Available This work reports on the implementation of electrospinning (ES as a facile route to encapsulate nano-engineered materials in a polystyrene (PS matrix. We applied ES to co-encapsulate two kinds of nanoparticles, i.e., upconversion nanophosphors (UCNPs and superparamagnetic iron oxide nanoparticles (SPIONs, in polystyrene (PS-based micro- and nano-fibers (PSFs. This approach made it possible to integrate near-infrared (NIR light-sensitive 500-nm β-NaYF4:Yb, Er UCNPs with 10-nm γ-Fe2O3 SPIONs in PS fibers. During the ES process, PSFs were additionally loaded with a well-established singlet oxygen (1∆g photosensitizer, rose bengal (RB. The thus obtained PSFs revealed the promising features of prospective multi-functional magnetic photoluminescent photocatalytic nano-constructs.

  6. First results on photon strength functions of 78Se from the two-step γ Cascades measurement

    Science.gov (United States)

    Valenta, Stanislav; Bečvář, František; Krtička, Milan; Tomandl, Ivo

    2017-09-01

    Two-step gamma cascades (TSCs) following the radiative capture of thermal neutrons in 77Se were measured at the research reactor at Řež near Prague. Results on photon strength functions (PSFs) of 78Se, obtained from comparison of experimental TSC spectra with outcomes of simulations under different assumptions about level density and PSFs using the DICEBOX algorithm, are presented. The main attention is paid to possible manifestation of the pygmy resonance observed recently in this nucleus in the nuclear resonance fluorescence measurement and low-energy PSF enhancement observed in Oslo-type experiments for all A ≲ 100 nuclei.

  7. A Practical Point Spread Model for Ocean Waters

    National Research Council Canada - National Science Library

    Hou, Weilin; Gray, Deric; Weidemann, Alan D; Arnone, Robert A

    2008-01-01

    .... These inherent optical properties (IOP), although measured frequently due to their important applications in ocean optics, especially in remote sensing, cannot be applied to underwater imaging issues directly, since they inherently reflect the chance of the single scattering.

  8. Development of Image Analysis Software of MAXI

    Science.gov (United States)

    Eguchi, S.; Ueda, Y.; Hiroi, K.; Isobe, N.; Sugizaki, M.; Suzuki, M.; Tomida, H.; Maxi Team

    2010-12-01

    Monitor of All-sky X-ray Image (MAXI) is an X-ray all-sky monitor, attached to the Japanese experiment module Kibo on the International Space Station. The main scientific goals of the MAXI mission include the discovery of X-ray novae followed by prompt alerts to the community (Negoro et al., in this conference), and production of X-ray all-sky maps and new source catalogs with unprecedented sensitivities. To extract the best capabilities of the MAXI mission, we are working on the development of detailed image analysis tools. We utilize maximum likelihood fitting to a projected sky image, where we take account of the complicated detector responses, such as the background and point spread functions (PSFs). The modeling of PSFs, which strongly depend on the orbit and attitude of MAXI, is a key element in the image analysis. In this paper, we present the status of our software development.

  9. Creation of an anti-imaging system using binary optics

    Science.gov (United States)

    Wang, Haifeng; Lin, Jian; Zhang, Dawei; Wang, Yang; Gu, Min; Urbach, H. P.; Gan, Fuxi; Zhuang, Songlin

    2016-01-01

    We present a concealing method in which an anti-point spread function (APSF) is generated using binary optics, which produces a large-scale dark area in the focal region that can hide any object located within it. This result is achieved by generating two identical PSFs of opposite signs, one consisting of positive electromagnetic waves from the zero-phase region of the binary optical element and the other consisting of negative electromagnetic waves from the pi-phase region of the binary optical element. PMID:27620068

  10. The Far-Infrared Surveyor (FIS) for AKARI

    OpenAIRE

    Kawada, Mitsunobu; Baba, Hajime; Barthel, Peter D.; Clements, David; Cohen, Martin; Doi, Yasuo; Figueredo, Elysandra; Fujiwara, Mikio; Goto, Tomotsugu; Hasegawa, Sunao; Hibi, Yasunori; Hirao, Takanori; Hiromoto, Norihisa; Jeong, Woong-Seob; Kaneda, Hidehiro

    2007-01-01

    The Far-Infrared Surveyor (FIS) is one of two focal plane instruments on the AKARI satellite. FIS has four photometric bands at 65, 90, 140, and 160 um, and uses two kinds of array detectors. The FIS arrays and optics are designed to sweep the sky with high spatial resolution and redundancy. The actual scan width is more than eight arcmin, and the pixel pitch is matches the diffraction limit of the telescope. Derived point spread functions (PSFs) from observations of asteroids are similar to ...

  11. On the simulation and mitigation of anisoplanatic optical turbulence for long range imaging

    Science.gov (United States)

    Hardie, Russell C.; LeMaster, Daniel A.

    2017-05-01

    We describe a numerical wave propagation method for simulating long range imaging of an extended scene under anisoplanatic conditions. Our approach computes an array of point spread functions (PSFs) for a 2D grid on the object plane. The PSFs are then used in a spatially varying weighted sum operation, with an ideal image, to produce a simulated image with realistic optical turbulence degradation. To validate the simulation we compare simulated outputs with the theoretical anisoplanatic tilt correlation and differential tilt variance. This is in addition to comparing the long- and short-exposure PSFs, and isoplanatic angle. Our validation analysis shows an excellent match between the simulation statistics and the theoretical predictions. The simulation tool is also used here to quantitatively evaluate a recently proposed block- matching and Wiener filtering (BMWF) method for turbulence mitigation. In this method block-matching registration algorithm is used to provide geometric correction for each of the individual input frames. The registered frames are then averaged and processed with a Wiener filter for restoration. A novel aspect of the proposed BMWF method is that the PSF model used for restoration takes into account the level of geometric correction achieved during image registration. This way, the Wiener filter is able fully exploit the reduced blurring achieved by registration. The BMWF method is relatively simple computationally, and yet, has excellent performance in comparison to state-of-the-art benchmark methods.

  12. Comparison and Validation of Point Spread Models for Imaging in Natural Waters

    National Research Council Canada - National Science Library

    Hou, Weilin; Gray, Deric; Weidemann, Alan; Arnone, Robert

    2008-01-01

    .... This will extend the performance range as well as the information retrieval from underwater electro-optical systems, which is critical in many civilian and military applications, including target...

  13. Functional

    Directory of Open Access Journals (Sweden)

    Fedoua Gandia

    2014-07-01

    Full Text Available The study was carried out to investigate the effects of inhaled Mg alone and associated with F in the treatment of bronchial hyperresponsiveness. 43 male Wistar rats were randomly divided into four groups and exposed to inhaled NaCl 0.9%, MeCh, MgSO4 and MgF2. Pulmonary changes were assessed by means of functional tests and quantitative histological examination of lungs and trachea. Results revealed that delivery of inhaled Mg associated with F led to a significant decrease of total lung resistance better than inhaled Mg alone (p < 0.05. Histological examinations illustrated that inhaled Mg associated with F markedly suppressed muscular hypertrophy (p = 0.034 and bronchoconstriction (p = 0.006 in MeCh treated rats better than inhaled Mg alone. No histological changes were found in the trachea. This study showed that inhaled Mg associated with F attenuated the main principle of the central components of changes in MeCh provoked experimental asthma better than inhaled Mg alone, potentially providing a new therapeutic approach against asthma.

  14. K-space model of motion artifacts in synthetic transmit aperture ultrasound imaging

    DEFF Research Database (Denmark)

    Nikolov, Svetoslav; Jensen, Jørgen Arendt

    2003-01-01

    Synthetic transmit aperture (STA) imaging gives the possibility to acquire an image with only few emissions and is appealing for 3D ultrasound imaging. Even though the number of emissions is low, the change in position of the scatterers prohibits the coherent summations of ultrasound echoes and l...... resolution image as a sum of rotated PSFs of a single LRI. The approximation is validated with a Field II simulation. The model predicts and explains the motion artifacts, and gives an intuitive feeling of what would happen for different velocities....... is used to develop an approximation of the point spread function (PSF) of a LRI. It is shown that the PSF of LRIs obtained by transmitting with different elements can be viewed as rotated versions of each other. Summing several LRIs gives a high resolution image. The model approximates the PSF of a high...

  15. The Far-Infrared Surveyor (FIS) for AKARI

    Science.gov (United States)

    Kawada, M.; Baba, H.; Barthel, P. D.; Clements, D.; Cohen, M.; Doi, Y.; Figueredo, E.; Fujiwara, M.; Goto, T.; Hasegawa, S.; Hibi, Y.; Hirao, T.; Hiromoto, N.; Jeong, W.-S.; Kaneda, H.; Kawai, T.; Kawamura, A.; Kester, D.; Kii, T.; Kobayashi, H.; Kwon, S. M.; Lee, H. M.; Makiuti, S.; Matsuo, H.; Matsuura, S.; Müller, T. G.; Murakami, N.; Nagata, H.; Nakagawa, T.; Narita, M.; Noda, M.; Oh, S. H.; Okada, Y.; Okuda, H.; Oliver, S.; Ootsubo, T.; Pak, S.; Park, Y.-S.; Pearson, C. P.; Rowan-Robinson, M.; Saito, T.; Salama, A.; Sato, S.; Savage, R. S.; Serjeant, S.; Shibai, H.; Shirahata, M.; Sohn, J.; Suzuki, T.; Takagi, T.; Takahashi, H.; Thomson, M.; Usui, F.; Verdugo, E.; Watabe, T.; White, G. J.; Wang, L.; Yamamura, I.; Yamauchi, C.; Yasuda, A.

    2007-10-01

    The Far-Infrared Surveyor (FIS) is one of two focal-plane instruments on the AKARI satellite. FIS has four photometric bands at 65, 90, 140, and 160 µm, and uses two kinds of array detectors. The FIS arrays and optics are designed to sweep the sky with high spatial resolution and redundancy. The actual scan width is more than eight arcminutes, and the pixel pitch matches the diffraction limit of the telescope. Derived point-spread functions (PSFs) from observations of asteroids are similar to those given by the optical model. Significant excesses, however, are clearly seen around tails of the PSFs, whose contributions are about 30% of the total power. All FIS functions are operating well in orbit, and the performance meets the laboratory characterizations, except for the two longer wavelength bands, which are not performing as well as characterized. Furthermore, the FIS has a spectroscopic capability using a Fourier transform spectrometer (FTS). Because the FTS takes advantage of the optics and detectors of the photometer, it can simultaneously make a spectral map. This paper summarizes the in-flight technical and operational performance of the FIS.

  16. Data reduction pipeline for the CHARIS integral-field spectrograph I: detector readout calibration and data cube extraction

    Science.gov (United States)

    Brandt, Timothy D.; Rizzo, Maxime; Groff, Tyler; Chilcote, Jeffrey; Greco, Johnny P.; Kasdin, N. Jeremy; Limbach, Mary Anne; Galvin, Michael; Loomis, Craig; Knapp, Gillian; McElwain, Michael W.; Jovanovic, Nemanja; Currie, Thayne; Mede, Kyle; Tamura, Motohide; Takato, Naruhisa; Hayashi, Masahiko

    2017-10-01

    We present the data reduction pipeline for CHARIS, a high-contrast integral-field spectrograph for the Subaru Telescope. The pipeline constructs a ramp from the raw reads using the measured nonlinear pixel response and reconstructs the data cube using one of three extraction algorithms: aperture photometry, optimal extraction, or χ2 fitting. We measure and apply both a detector flatfield and a lenslet flatfield and reconstruct the wavelength- and position-dependent lenslet point-spread function (PSF) from images taken with a tunable laser. We use these measured PSFs to implement a χ2-based extraction of the data cube, with typical residuals of ˜5% due to imperfect models of the undersampled lenslet PSFs. The full two-dimensional residual of the χ2 extraction allows us to model and remove correlated read noise, dramatically improving CHARIS's performance. The χ2 extraction produces a data cube that has been deconvolved with the line-spread function and never performs any interpolations of either the data or the individual lenslet spectra. The extracted data cube also includes uncertainties for each spatial and spectral measurement. CHARIS's software is parallelized, written in Python and Cython, and freely available on github with a separate documentation page. Astrometric and spectrophotometric calibrations of the data cubes and PSF subtraction will be treated in a forthcoming paper.

  17. Isotope specific resolution recovery image reconstruction in high resolution PET imaging.

    Science.gov (United States)

    Kotasidis, Fotis A; Angelis, Georgios I; Anton-Rodriguez, Jose; Matthews, Julian C; Reader, Andrew J; Zaidi, Habib

    2014-05-01

    Measuring and incorporating a scanner-specific point spread function (PSF) within image reconstruction has been shown to improve spatial resolution in PET. However, due to the short half-life of clinically used isotopes, other long-lived isotopes not used in clinical practice are used to perform the PSF measurements. As such, non-optimal PSF models that do not correspond to those needed for the data to be reconstructed are used within resolution modeling (RM) image reconstruction, usually underestimating the true PSF owing to the difference in positron range. In high resolution brain and preclinical imaging, this effect is of particular importance since the PSFs become more positron range limited and isotope-specific PSFs can help maximize the performance benefit from using resolution recovery image reconstruction algorithms. In this work, the authors used a printing technique to simultaneously measure multiple point sources on the High Resolution Research Tomograph (HRRT), and the authors demonstrated the feasibility of deriving isotope-dependent system matrices from fluorine-18 and carbon-11 point sources. Furthermore, the authors evaluated the impact of incorporating them within RM image reconstruction, using carbon-11 phantom and clinical datasets on the HRRT. The results obtained using these two isotopes illustrate that even small differences in positron range can result in different PSF maps, leading to further improvements in contrast recovery when used in image reconstruction. The difference is more pronounced in the centre of the field-of-view where the full width at half maximum (FWHM) from the positron range has a larger contribution to the overall FWHM compared to the edge where the parallax error dominates the overall FWHM. Based on the proposed methodology, measured isotope-specific and spatially variant PSFs can be reliably derived and used for improved spatial resolution and variance performance in resolution recovery image reconstruction. The

  18. Isotope specific resolution recovery image reconstruction in high resolution PET imaging

    International Nuclear Information System (INIS)

    Kotasidis, Fotis A.; Angelis, Georgios I.; Anton-Rodriguez, Jose; Matthews, Julian C.; Reader, Andrew J.; Zaidi, Habib

    2014-01-01

    Purpose: Measuring and incorporating a scanner-specific point spread function (PSF) within image reconstruction has been shown to improve spatial resolution in PET. However, due to the short half-life of clinically used isotopes, other long-lived isotopes not used in clinical practice are used to perform the PSF measurements. As such, non-optimal PSF models that do not correspond to those needed for the data to be reconstructed are used within resolution modeling (RM) image reconstruction, usually underestimating the true PSF owing to the difference in positron range. In high resolution brain and preclinical imaging, this effect is of particular importance since the PSFs become more positron range limited and isotope-specific PSFs can help maximize the performance benefit from using resolution recovery image reconstruction algorithms. Methods: In this work, the authors used a printing technique to simultaneously measure multiple point sources on the High Resolution Research Tomograph (HRRT), and the authors demonstrated the feasibility of deriving isotope-dependent system matrices from fluorine-18 and carbon-11 point sources. Furthermore, the authors evaluated the impact of incorporating them within RM image reconstruction, using carbon-11 phantom and clinical datasets on the HRRT. Results: The results obtained using these two isotopes illustrate that even small differences in positron range can result in different PSF maps, leading to further improvements in contrast recovery when used in image reconstruction. The difference is more pronounced in the centre of the field-of-view where the full width at half maximum (FWHM) from the positron range has a larger contribution to the overall FWHM compared to the edge where the parallax error dominates the overall FWHM. Conclusions: Based on the proposed methodology, measured isotope-specific and spatially variant PSFs can be reliably derived and used for improved spatial resolution and variance performance in resolution

  19. Methods for deconvolving sparse positive delta function series

    International Nuclear Information System (INIS)

    Trussell, H.J.; Schwalbe, L.A.

    1981-01-01

    Sparse delta function series occur as data in many chemical analyses and seismic methods. These original data are often sufficiently degraded by the recording instrument response that the individual delta function peaks are difficult to distinguish and measure. A method, which has been used to measure these peaks, is to fit a parameterized model by a nonlinear least-squares fitting algorithm. The deconvolution approaches described have the advantage of not requiring a parameterized point spread function, nor do they expect a fixed number of peaks. Two new methods are presented. The maximum power technique is reviewed. A maximum a posteriori technique is introduced. Results on both simulated and real data by the two methods are presented. The characteristics of the data can determine which method gives superior results. 5 figures

  20. SU-E-J-69: Iterative Deconvolution of the Initial Photon Fluence for EPID Dosimetry: A Monte Carlo Based Study

    Energy Technology Data Exchange (ETDEWEB)

    Czarnecki, D; Voigts-Rhetz, P von; Shishechian, D Uchimura [Technische Hochschule Mittelhessen - University of Applied Sciences, Giessen (Germany); Zink, K [Technische Hochschule Mittelhessen - University of Applied Sciences, Giessen (Germany); Germany and Department of Radiotherapy and Radiooncology, University Medical Center Giessen-Marburg, Marburg (Germany)

    2015-06-15

    Purpose: Developing a fast and accurate calculation model to reconstruct the applied photon fluence from an external photon radiation therapy treatment based on an image recorded by an electronic portal image device (EPID). Methods: To reconstruct the initial photon fluence the 2D EPID image was corrected for scatter from the patient/phantom and EPID to generate the transmitted primary photon fluence. This was done by an iterative deconvolution using precalculated point spread functions (PSF). The transmitted primary photon fluence was then backprojected through the patient/phantom geometry considering linear attenuation to receive the initial photon fluence applied for the treatment.The calculation model was verified using Monte Carlo simulations performed with the EGSnrc code system. EPID images were produced by calculating the dose deposition in the EPID from a 6 MV photon beam irradiating a water phantom with air and bone inhomogeneities and the ICRP anthropomorphic voxel phantom. Results: The initial photon fluence was reconstructed using a single PSF and position dependent PSFs which depend on the radiological thickness of the irradiated object. Appling position dependent point spread functions the mean uncertainty of the reconstructed initial photon fluence could be reduced from 1.13 % to 0.13 %. Conclusion: This study presents a calculation model for fluence reconstruction from EPID images. The{sup Result} show a clear advantage when position dependent PSF are used for the iterative reconstruction. The basic work of a reconstruction method was established and further evaluations must be made in an experimental study.

  1. Model-based PSF and MTF estimation and validation from skeletal clinical CT images

    Energy Technology Data Exchange (ETDEWEB)

    Pakdel, Amirreza [Sunnybrook Research Institute, Toronto, Ontario M4N 3M5, Canada and Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3M2 (Canada); Mainprize, James G.; Robert, Normand [Sunnybrook Research Institute, Toronto, Ontario M4N 3M5 (Canada); Fialkov, Jeffery [Division of Plastic Surgery, Sunnybrook Health Sciences Center, Toronto, Ontario M4N 3M5, Canada and Department of Surgery, University of Toronto, Toronto, Ontario M5S 3M2 (Canada); Whyne, Cari M., E-mail: cari.whyne@sunnybrook.ca [Sunnybrook Research Institute, Toronto, Ontario M4N 3M5, Canada and Department of Surgery, Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3M2 (Canada)

    2014-01-15

    Purpose: A method was developed to correct for systematic errors in estimating the thickness of thin bones due to image blurring in CT images using bone interfaces to estimate the point-spread-function (PSF). This study validates the accuracy of the PSFs estimated using said method from various clinical CT images featuring cortical bones. Methods: Gaussian PSFs, characterized by a different extent in the z (scan) direction than in the x and y directions were obtained using our method from 11 clinical CT scans of a cadaveric craniofacial skeleton. These PSFs were estimated for multiple combinations of scanning parameters and reconstruction methods. The actual PSF for each scan setting was measured using the slanted-slit technique within the image slice plane and the longitudinal axis. The Gaussian PSF and the corresponding modulation transfer function (MTF) are compared against the actual PSF and MTF for validation. Results: The differences (errors) between the actual and estimated full-width half-max (FWHM) of the PSFs were 0.09 ± 0.05 and 0.14 ± 0.11 mm for the xy and z axes, respectively. The overall errors in the predicted frequencies measured at 75%, 50%, 25%, 10%, and 5% MTF levels were 0.06 ± 0.07 and 0.06 ± 0.04 cycles/mm for the xy and z axes, respectively. The accuracy of the estimates was dependent on whether they were reconstructed with a standard kernel (Toshiba's FC68, mean error of 0.06 ± 0.05 mm, MTF mean error 0.02 ± 0.02 cycles/mm) or a high resolution bone kernel (Toshiba's FC81, PSF FWHM error 0.12 ± 0.03 mm, MTF mean error 0.09 ± 0.08 cycles/mm). Conclusions: The method is accurate in 3D for an image reconstructed using a standard reconstruction kernel, which conforms to the Gaussian PSF assumption but less accurate when using a high resolution bone kernel. The method is a practical and self-contained means of estimating the PSF in clinical CT images featuring cortical bones, without the need phantoms or any prior knowledge

  2. Pupil filter design by using a Bessel functions basis at the image plane.

    Science.gov (United States)

    Canales, Vidal F; Cagigal, Manuel P

    2006-10-30

    Many applications can benefit from the use of pupil filters for controlling the light intensity distribution near the focus of an optical system. Most of the design methods for such filters are based on a second-order expansion of the Point Spread Function (PSF). Here, we present a new procedure for designing radially-symmetric pupil filters. It is more precise than previous procedures as it considers the exact expression of the PSF, expanded as a function of first-order Bessel functions. Furthermore, this new method presents other advantages: the height of the side lobes can be easily controlled, it allows the design of amplitude-only, phase-only or hybrid filters, and the coefficients of the PSF expansion can be directly related to filter parameters. Finally, our procedure allows the design of filters with very different behaviours and optimal performance.

  3. Improved Hand Function, Self-Rated Health and Decreased Activity Limitations - results after a two month hand osteoarthritis group intervention.

    Science.gov (United States)

    Bjurehed, Linda; Brodin, Nina; Nordenskiöld, Ulla; Björk, Mathilda

    2017-10-03

    Hand Osteoarthritis (hand OA) causes pain, impaired mobility and reduced grip force, which cause activity limitations. Osteoarthritis group interventions in primary care settings are sparsely reported. To evaluate the effects on hand function, activity limitations and self-rated health of a primary care hand OA group intervention. 64 individuals with hand OA agreed to participate, 15 were excluded due to not fulfilling the inclusion criteria. The 49 remaining (90% female) participated in OA group intervention at a primary care unit with education, paraffin wax bath and hand exercise over a six-week period. Data were collected at baseline, end of intervention and after one year. Instruments used were the Grip Ability Test (GAT), the Signals of Functional Impairment (SOFI), the JAMAR (dynamometry), hand pain at rest using Visual Analogue Scale (VAS), the Patient Specific Functional Scale (PSFS), the Quick Disabilities of the Arm, Shoulders and Hand (Quick-DASH) and the EuroQol VAS (EQ VAS). Data were analyzed using nonparametric statistics. Hand function, activity limitation and self-rated health significantly improved from baseline to end of intervention, JAMAR (right hand, plimitation and self-rated health. The benefits are sustained one year after completion of the intervention. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  4. Retinal image degradation by optical aberrations and light scatter in normal and albino chick eyes

    Science.gov (United States)

    Tian, Yibin; Shieh, Kevin; Wildsoet, Christine F.

    2007-02-01

    Comprehensive evaluation of retinal image quality requires that light scatter as well as optical aberrations be considered. In investigating how retinal image degradation affects eye growth in the chick model of myopia, we developed a simple method based on Shack-Hartmann images for evaluating the effects of both monochromatic aberrations and light scatter on retinal image quality. We further evaluated our method in the current study by applying it to data collected from both normal chick eyes and albino eyes that were expected to show increased intraocular light scatter. To analyze light scatter in our method, each Shack-Hartmann dot is treated as a local point spread function (PSF) that is the convolution of a local scatter PSF and a lenslet diffraction PSF. The local scatter PSF is obtained by de-convolution, and is fitted with a circularly symmetric Gaussian function using nonlinear regressions. A whole-eye scatter PSF also can be derived from the local scatter PSFs for the analyzed pupil. Aberrations are analyzed using OSA standard Zernike polynomials, and aberration-related PSF calculated from reconstructed wavefront using fast Fourier transform. Modulation transfer functions (MTFs) are computed separately for aberration and scatter PSFs, and a whole-eye MTF is derived as the product of the two. This method was applied to 4 normal and 4 albino eyes. Compared to normal eyes, albino eyes were more aberrated and showed greater light scatter. As a result, overall retinal image degradation was much greater in albino eyes than in normal eyes, with the relative contribution to retinal image degradation of light scatter compared to aberrations also being greater for albino eyes.

  5. Sharper Fermi LAT Images: Instrument Response Functions for an Improved Event Selection

    Science.gov (United States)

    Portillo, Stephen K. N.; Finkbeiner, Douglas P.

    2014-11-01

    The Large Area Telescope (LAT) on the Fermi Gamma-ray Space Telescope has a point-spread function (PSF) with large tails, consisting of events affected by tracker inefficiencies, inactive volumes, and hard scattering; these tails can make source confusion a limiting factor. The parameter CTBCORE, available in the publicly available Extended Fermi LAT data (available at http://fermi.gsfc.nasa.gov/ssc/data/access/), estimates the quality of each event's direction reconstruction; by implementing a cut in this parameter, the tails of the PSF can be suppressed at the cost of losing effective area. We implement cuts on CTBCORE and present updated instrument response functions derived from the Fermi LAT data itself, along with all-sky maps generated with these cuts. Having shown the effectiveness of these cuts, especially at low energies, we encourage their use in analyses where angular resolution is more important than Poisson noise.

  6. Sharper Fermi LAT images: instrument response functions for an improved event selection

    Energy Technology Data Exchange (ETDEWEB)

    Portillo, Stephen K. N.; Finkbeiner, Douglas P. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, MS-51, Cambridge, MA 02138 (United States)

    2014-11-20

    The Large Area Telescope (LAT) on the Fermi Gamma-ray Space Telescope has a point-spread function (PSF) with large tails, consisting of events affected by tracker inefficiencies, inactive volumes, and hard scattering; these tails can make source confusion a limiting factor. The parameter CTBCORE, available in the publicly available Extended Fermi LAT data (available at http://fermi.gsfc.nasa.gov/ssc/data/access/), estimates the quality of each event's direction reconstruction; by implementing a cut in this parameter, the tails of the PSF can be suppressed at the cost of losing effective area. We implement cuts on CTBCORE and present updated instrument response functions derived from the Fermi LAT data itself, along with all-sky maps generated with these cuts. Having shown the effectiveness of these cuts, especially at low energies, we encourage their use in analyses where angular resolution is more important than Poisson noise.

  7. Geometrical optical transfer function: is it worth calculating?

    Science.gov (United States)

    Díaz, José A; Mahajan, Virendra N

    2017-10-01

    In this paper, we explore the merit of calculating the geometrical optical transfer function (GOTF) in optical design by comparing the time to calculate it with the time to calculate the diffraction optical transfer function (DOTF). We determine the DOTF by numerical integration of the pupil function autocorrelation (that reduces to an integration of a complex exponential of the aberration difference function), 2D digital autocorrelation of the pupil function, and the Fourier transform (FT) of the point-spread function (PSF); and we determine the GOTF by the FT of the geometrical PSF (that reduces to an integration over the pupil plane of a complex exponential that is a scalar product of the spatial frequency and transverse ray aberration vectors) and the FT of the spot diagram. Our starting point for calculating the DOTF is the wave aberrations of the system in its pupil plane, and the transverse ray aberrations in the image plane for the GOTF. Numerical results for primary aberrations and some typical imaging systems show that the direct numerical integrations are slow, but the GOTF calculation by a FT of the spot diagram is two or even three times slower than the DOTF calculation by an FT of the PSF, depending on the aberration. We conclude that the calculation of GOTF is, at best, an approximation of the DOTF and only for large aberrations; GOTF does not offer any advantage in the optical design process, and hence negates its utility.

  8. SU-E-I-109: Sensitivity Analysis of an Electronic Portal Imaging Device Monte Carlo Model to Variations in Optical Transport Parameters.

    Science.gov (United States)

    Blake, S; Vial, P; Holloway, L; McNamara, A; Greer, P; Kuncic, Z

    2012-06-01

    To investigate the sensitivity of a Monte Carlo (MC) model of a standard clinical amorphous silicon (a-Si) electron portal imaging device (EPID) to variations in optical photon transport parameters. The Geant4 MC toolkit was used to develop a comprehensive model of an indirect-detection a-Si EPID incorporating x-ray and optical photon transport. The EPID was modeled as a series of uniform layers with properties specified by the manufacturer (PerkinElmer, Santa Clara, CA) of a research EPID at our centre. Optical processes that were modeled include bulk absorption, Rayleigh scattering, and boundary processes (reflection and refraction). Model performance was evaluated by scoring optical photons absorbed by the a-Si photodiode as a function of radial distance from a point source of x-rays on an event-by-event basis (0.025 mm resolution). Primary x-ray energies were sampled from a clinical 6 MV photon spectrum. Simulations were performed by varying optical transport parameters and the resulting point spread functions (PSFs) were compared. The optical parameters investigated include: x-ray transport cutoff thresholds; absorption path length; optical energy spectrum; refractive indices; and the 'roughness' of boundaries within phosphor screen layers. The transport cutoffs and refractive indices studied were found to minimally affect resulting PSFs. A monoenergetic optical spectrum slightly broadened the PSF in comparison with the use of a polyenergetic spectrum. The absorption path length only significantly altered the PSF when decreased drastically. Variations in the treatment of boundaries noticeably broadened resulting PSFs. Variation in optical transport parameters was found to affect resulting PSF calculations. Current work is focusing on repeating this analysis with a coarser resolution more typical of a commercial a-Si EPID to observe if these effects continue to alter the EPID PSF. Experimental measurement of the EPID line spread function to validate these

  9. Reducing depth induced spherical aberration in 3D widefield fluorescence microscopy by wavefront coding using the SQUBIC phase mask

    Science.gov (United States)

    Patwary, Nurmohammed; Doblas, Ana; King, Sharon V.; Preza, Chrysanthe

    2014-03-01

    Imaging thick biological samples introduces spherical aberration (SA) due to refractive index (RI) mismatch between specimen and imaging lens immersion medium. SA increases with the increase of either depth or RI mismatch. Therefore, it is difficult to find a static compensator for SA1. Different wavefront coding methods2,3 have been studied to find an optimal way of static wavefront correction to reduce depth-induced SA. Inspired by a recent design of a radially symmetric squared cubic (SQUBIC) phase mask that was tested for scanning confocal microscopy1 we have modified the pupil using the SQUBIC mask to engineer the point spread function (PSF) of a wide field fluorescence microscope. In this study, simulated images of a thick test object were generated using a wavefront encoded engineered PSF (WFEPSF) and were restored using space-invariant (SI) and depth-variant (DV) expectation maximization (EM) algorithms implemented in the COSMOS software4. Quantitative comparisons between restorations obtained with both the conventional and WFE PSFs are presented. Simulations show that, in the presence of SA, the use of the SIEM algorithm and a single SQUBIC encoded WFE-PSF can yield adequate image restoration. In addition, in the presence of a large amount of SA, it is possible to get adequate results using the DVEM with fewer DV-PSFs than would typically be required for processing images acquired with a clear circular aperture (CCA) PSF. This result implies that modification of a widefield system with the SQUBIC mask renders the system less sensitive to depth-induced SA and suitable for imaging samples at larger optical depths.

  10. Linking self-determined functional problems of patients with neck pain to the International Classification of Functioning, Disability, and Health (ICF

    Directory of Open Access Journals (Sweden)

    Andelic N

    2012-10-01

    activities (d920; 13%. Only two meaningful concepts, described as “be active” and “to function after activities,” were not assigned to a specific ICF category.Conclusion: The majority of the specific functional problems presented by patients in this study showed a good fit with the ICF model. The substantial number of links to the activities and participation categories, such as mobility, domestic life, employment, and social and civic life, suggests that a comprehensive approach, as well as the involvement of a multidisciplinary team, should be present in the rehabilitation of neck pain-related disability.Keywords: neck pain disability, self-determined functional problems, PSFS, ICF

  11. Simulation of anisoplanatic imaging through optical turbulence using numerical wave propagation with new validation analysis

    Science.gov (United States)

    Hardie, Russell C.; Power, Jonathan D.; LeMaster, Daniel A.; Droege, Douglas R.; Gladysz, Szymon; Bose-Pillai, Santasri

    2017-07-01

    We present a numerical wave propagation method for simulating imaging of an extended scene under anisoplanatic conditions. While isoplanatic simulation is relatively common, few tools are specifically designed for simulating the imaging of extended scenes under anisoplanatic conditions. We provide a complete description of the proposed simulation tool, including the wave propagation method used. Our approach computes an array of point spread functions (PSFs) for a two-dimensional grid on the object plane. The PSFs are then used in a spatially varying weighted sum operation, with an ideal image, to produce a simulated image with realistic optical turbulence degradation. The degradation includes spatially varying warping and blurring. To produce the PSF array, we generate a series of extended phase screens. Simulated point sources are numerically propagated from an array of positions on the object plane, through the phase screens, and ultimately to the focal plane of the simulated camera. Note that the optical path for each PSF will be different, and thus, pass through a different portion of the extended phase screens. These different paths give rise to a spatially varying PSF to produce anisoplanatic effects. We use a method for defining the individual phase screen statistics that we have not seen used in previous anisoplanatic simulations. We also present a validation analysis. In particular, we compare simulated outputs with the theoretical anisoplanatic tilt correlation and a derived differential tilt variance statistic. This is in addition to comparing the long- and short-exposure PSFs and isoplanatic angle. We believe this analysis represents the most thorough validation of an anisoplanatic simulation to date. The current work is also unique that we simulate and validate both constant and varying Cn2(z) profiles. Furthermore, we simulate sequences with both temporally independent and temporally correlated turbulence effects. Temporal correlation is introduced

  12. The HST/WFC3 Quicklook Project: A User Interface to Hubble Space Telescope Wide Field Camera 3 Data

    Science.gov (United States)

    Bourque, Matthew; Bajaj, Varun; Bowers, Ariel; Dulude, Michael; Durbin, Meredith; Gosmeyer, Catherine; Gunning, Heather; Khandrika, Harish; Martlin, Catherine; Sunnquist, Ben; Viana, Alex

    2017-06-01

    The Hubble Space Telescope's Wide Field Camera 3 (WFC3) instrument, comprised of two detectors, UVIS (Ultraviolet-Visible) and IR (Infrared), has been acquiring ~ 50-100 images daily since its installation in 2009. The WFC3 Quicklook project provides a means for instrument analysts to store, calibrate, monitor, and interact with these data through the various Quicklook systems: (1) a ~ 175 TB filesystem, which stores the entire WFC3 archive on disk, (2) a MySQL database, which stores image header data, (3) a Python-based automation platform, which currently executes 22 unique calibration/monitoring scripts, (4) a Python-based code library, which provides system functionality such as logging, downloading tools, database connection objects, and filesystem management, and (5) a Python/Flask-based web interface to the Quicklook system. The Quicklook project has enabled large-scale WFC3 analyses and calibrations, such as the monitoring of the health and stability of the WFC3 instrument, the measurement of ~ 20 million WFC3/UVIS Point Spread Functions (PSFs), the creation of WFC3/IR persistence calibration products, and many others.

  13. An integrated gait rehabilitation training based on Functional Electrical Stimulation cycling and overground robotic exoskeleton in complete spinal cord injury patients: Preliminary results.

    Science.gov (United States)

    Mazzoleni, S; Battini, E; Rustici, A; Stampacchia, G

    2017-07-01

    The aim of this study is to investigate the effects of an integrated gait rehabilitation training based on Functional Electrical Stimulation (FES)-cycling and overground robotic exoskeleton in a group of seven complete spinal cord injury patients on spasticity and patient-robot interaction. They underwent a robot-assisted rehabilitation training based on two phases: n=20 sessions of FES-cycling followed by n= 20 sessions of robot-assisted gait training based on an overground robotic exoskeleton. The following clinical outcome measures were used: Modified Ashworth Scale (MAS), Numerical Rating Scale (NRS) on spasticity, Penn Spasm Frequency Scale (PSFS), Spinal Cord Independence Measure Scale (SCIM), NRS on pain and International Spinal Cord Injury Pain Data Set (ISCI). Clinical outcome measures were assessed before (T0) after (T1) the FES-cycling training and after (T2) the powered overground gait training. The ability to walk when using exoskeleton was assessed by means of 10 Meter Walk Test (10MWT), 6 Minute Walk Test (6MWT), Timed Up and Go test (TUG), standing time, walking time and number of steps. Statistically significant changes were found on the MAS score, NRS-spasticity, 6MWT, TUG, standing time and number of steps. The preliminary results of this study show that an integrated gait rehabilitation training based on FES-cycling and overground robotic exoskeleton in complete SCI patients can provide a significant reduction of spasticity and improvements in terms of patient-robot interaction.

  14. Measurement of the presampled two-dimensional modulation transfer function of digital imaging systems

    International Nuclear Information System (INIS)

    Fetterly, Kenneth A.; Hangiandreou, Nicholas J.; Schueler, Beth A.; Ritenour, E. Russell

    2002-01-01

    The purpose of this work was to develop methods to measure the presampled two-dimensional modulation transfer function (2D MTF) of digital imaging systems. A custom x-ray 'point source' phantom was created by machining 256 holes with diameter 0.107 mm through a 0.5-mm-thick copper plate. The phantom was imaged several times, resulting in many images of individual x-ray 'spots'. The center of each spot (with respect to the pixel matrix) was determined to subpixel accuracy by fitting each spot to a 2D Gaussian function. The subpixel spot center locations were used to create a 5x oversampled system point spread function (PSF), which characterizes the optical and electrical properties of the system and is independent of the pixel sampling of the original image. The modulus of the Fourier transform of the PSF was calculated. Next, the Fourier function was normalized to the zero frequency value. Finally, the Fourier transform function was divided by the first-order Bessel function that defined the frequency content of the holes, resulting in the presampled 2D MTF. The presampled 2D MTF of a 0.1 mm pixel pitch computed radiography system and 0.2 mm pixel pitch flat panel digital imaging system that utilized a cesium iodide scintillator was measured. Comparison of the axial components of the 2D MTF to one-dimensional MTF measurements acquired using an edge device method demonstrated that the two methods produced consistent results

  15. The status of MUSIC: the multiwavelength sub-millimeter inductance camera

    Science.gov (United States)

    Sayers, Jack; Bockstiegel, Clint; Brugger, Spencer; Czakon, Nicole G.; Day, Peter K.; Downes, Thomas P.; Duan, Ran P.; Gao, Jiansong; Gill, Amandeep K.; Glenn, Jason; Golwala, Sunil R.; Hollister, Matthew I.; Lam, Albert; LeDuc, Henry G.; Maloney, Philip R.; Mazin, Benjamin A.; McHugh, Sean G.; Miller, David A.; Mroczkowski, Anthony K.; Noroozian, Omid; Nguyen, Hien Trong; Schlaerth, James A.; Siegel, Seth R.; Vayonakis, Anastasios; Wilson, Philip R.; Zmuidzinas, Jonas

    2014-08-01

    The Multiwavelength Sub/millimeter Inductance Camera (MUSIC) is a four-band photometric imaging camera operating from the Caltech Submillimeter Observatory (CSO). MUSIC is designed to utilize 2304 microwave kinetic inductance detectors (MKIDs), with 576 MKIDs for each observing band centered on 150, 230, 290, and 350 GHz. MUSIC's field of view (FOV) is 14' square, and the point-spread functions (PSFs) in the four observing bands have 45'', 31'', 25'', and 22'' full-widths at half maximum (FWHM). The camera was installed in April 2012 with 25% of its nominal detector count in each band, and has subsequently completed three short sets of engineering observations and one longer duration set of early science observations. Recent results from on-sky characterization of the instrument during these observing runs are presented, including achieved map- based sensitivities from deep integrations, along with results from lab-based measurements made during the same period. In addition, recent upgrades to MUSIC, which are expected to significantly improve the sensitivity of the camera, are described.

  16. Gaussian Process Kalman Filter for Focal Plane Wavefront Correction and Exoplanet Signal Extraction

    Science.gov (United States)

    Sun, He; Kasdin, N. Jeremy

    2018-01-01

    Currently, the ultimate limitation of space-based coronagraphy is the ability to subtract the residual PSF after wavefront correction to reveal the planet. Called reference difference imaging (RDI), the technique consists of conducting wavefront control to collect the reference point spread function (PSF) by observing a bright star, and then extracting target planet signals by subtracting a weighted sum of reference PSFs. Unfortunately, this technique is inherently inefficient because it spends a significant fraction of the observing time on the reference star rather than the target star with the planet. Recent progress in model based wavefront estimation suggests an alternative approach. A Kalman filter can be used to estimate the stellar PSF for correction by the wavefront control system while simultaneously estimating the planet signal. Without observing the reference star, the (extended) Kalman filter directly utilizes the wavefront correction data and combines the time series observations and model predictions to estimate the stellar PSF and planet signals. Because wavefront correction is used during the entire observation with no slewing, the system has inherently better stability. In this poster we show our results aimed at further improving our Kalman filter estimation accuracy by including not only temporal correlations but also spatial correlations among neighboring pixels in the images. This technique is known as a Gaussian process Kalman filter (GPKF). We also demonstrate the advantages of using a Kalman filter rather than RDI by simulating a real space exoplanet detection mission.

  17. Sodium ((23)Na) ultra-short echo time imaging in the human brain using a 3D-Cones trajectory.

    Science.gov (United States)

    Riemer, Frank; Solanky, Bhavana S; Stehning, Christian; Clemence, Matthew; Wheeler-Kingshott, Claudia A M; Golay, Xavier

    2014-02-01

    Sodium magnetic resonance imaging ((23)Na-MRI) of the brain has shown changes in (23)Na signal as a hallmark of various neurological diseases such as stroke, Alzheimer's disease, Multiple Sclerosis and Huntington's disease. To improve scan times and image quality, we have implemented the 3D-Cones (CN) sequence for in vivo (23)Na brain MRI. Using signal-to-noise (SNR) as a measurement of sequence performance, CN is compared against more established 3D-radial k-space sampling schemes featuring cylindrical stack-of-stars (SOS) and 3D-spokes kooshball (KB) trajectories, on five healthy volunteers in a clinical setting. Resolution was evaluated by simulating the point-spread-functions (PSFs) and experimental measures on a phantom. All sequences were shown to have a similar SNR arbitrary units (AU) of 6-6.5 in brain white matter, 7-9 in gray matter and 17-18 AU in cerebrospinal fluid. SNR between white and gray matter were significantly different for KB and CN (p = 0.046 and time with no significant trade-off in SNR is achieved. CN is therefore more suitable for (23)Na-MRI in the brain.

  18. The diffractive achromat full spectrum computational imaging with diffractive optics

    KAUST Repository

    Peng, Yifan

    2016-07-11

    Diffractive optical elements (DOEs) have recently drawn great attention in computational imaging because they can drastically reduce the size and weight of imaging devices compared to their refractive counterparts. However, the inherent strong dispersion is a tremendous obstacle that limits the use of DOEs in full spectrum imaging, causing unacceptable loss of color fidelity in the images. In particular, metamerism introduces a data dependency in the image blur, which has been neglected in computational imaging methods so far. We introduce both a diffractive achromat based on computational optimization, as well as a corresponding algorithm for correction of residual aberrations. Using this approach, we demonstrate high fidelity color diffractive-only imaging over the full visible spectrum. In the optical design, the height profile of a diffractive lens is optimized to balance the focusing contributions of different wavelengths for a specific focal length. The spectral point spread functions (PSFs) become nearly identical to each other, creating approximately spectrally invariant blur kernels. This property guarantees good color preservation in the captured image and facilitates the correction of residual aberrations in our fast two-step deconvolution without additional color priors. We demonstrate our design of diffractive achromat on a 0.5mm ultrathin substrate by photolithography techniques. Experimental results show that our achromatic diffractive lens produces high color fidelity and better image quality in the full visible spectrum. © 2016 ACM.

  19. Performance Evaluation of Large Aperture 'Polished Panel' Optical Receivers Based on Experimental Data

    Science.gov (United States)

    Vilnrotter, Victor

    2013-01-01

    Recent interest in hybrid RF/Optical communications has led to the development and installation of a "polished-panel" optical receiver evaluation assembly on the 34-meter research antenna at Deep-Space Station 13 (DSS-13) at NASA's Goldstone Communications Complex. The test setup consists of a custom aluminum panel polished to optical smoothness, and a large-sensor CCD camera designed to image the point-spread function (PSF) generated by the polished aluminum panel. Extensive data has been obtained via realtime tracking and imaging of planets and stars at DSS-13. Both "on-source" and "off-source" data were recorded at various elevations, enabling the development of realistic simulations and analytic models to help determine the performance of future deep-space communications systems operating with on-off keying (OOK) or pulse-position-modulated (PPM) signaling formats with photon-counting detection, and compared with the ultimate quantum bound on detection performance for these modulations. Experimentally determined PSFs were scaled to provide realistic signal-distributions across a photon-counting detector array when a pulse is received, and uncoded as well as block-coded performance analyzed and evaluated for a well-known class of block codes.

  20. Tomographic PIV: particles versus blobs

    International Nuclear Information System (INIS)

    Champagnat, Frédéric; Cornic, Philippe; Besnerais, Guy Le; Plyer, Aurélien; Cheminet, Adam; Leclaire, Benjamin

    2014-01-01

    We present an alternative approach to tomographic particle image velocimetry (tomo-PIV) that seeks to recover nearly single voxel particles rather than blobs of extended size. The baseline of our approach is a particle-based representation of image data. An appropriate discretization of this representation yields an original linear forward model with a weight matrix built with specific samples of the system’s point spread function (PSF). Such an approach requires only a few voxels to explain the image appearance, therefore it favors much more sparsely reconstructed volumes than classic tomo-PIV. The proposed forward model is general and flexible and can be embedded in a classical multiplicative algebraic reconstruction technique (MART) or a simultaneous multiplicative algebraic reconstruction technique (SMART) inversion procedure. We show, using synthetic PIV images and by way of a large exploration of the generating conditions and a variety of performance metrics, that the model leads to better results than the classical tomo-PIV approach, in particular in the case of seeding densities greater than 0.06 particles per pixel and of PSFs characterized by a standard deviation larger than 0.8 pixels. (paper)

  1. Modeling digital breast tomosynthesis imaging systems for optimization studies

    Science.gov (United States)

    Lau, Beverly Amy

    Digital breast tomosynthesis (DBT) is a new imaging modality for breast imaging. In tomosynthesis, multiple images of the compressed breast are acquired at different angles, and the projection view images are reconstructed to yield images of slices through the breast. One of the main problems to be addressed in the development of DBT is the optimal parameter settings to obtain images ideal for detection of cancer. Since it would be unethical to irradiate women multiple times to explore potentially optimum geometries for tomosynthesis, it is ideal to use a computer simulation to generate projection images. Existing tomosynthesis models have modeled scatter and detector without accounting for oblique angles of incidence that tomosynthesis introduces. Moreover, these models frequently use geometry-specific physical factors measured from real systems, which severely limits the robustness of their algorithms for optimization. The goal of this dissertation was to design the framework for a computer simulation of tomosynthesis that would produce images that are sensitive to changes in acquisition parameters, so an optimization study would be feasible. A computer physics simulation of the tomosynthesis system was developed. The x-ray source was modeled as a polychromatic spectrum based on published spectral data, and inverse-square law was applied. Scatter was applied using a convolution method with angle-dependent scatter point spread functions (sPSFs), followed by scaling using an angle-dependent scatter-to-primary ratio (SPR). Monte Carlo simulations were used to generate sPSFs for a 5-cm breast with a 1-cm air gap. Detector effects were included through geometric propagation of the image onto layers of the detector, which were blurred using depth-dependent detector point-spread functions (PRFs). Depth-dependent PRFs were calculated every 5-microns through a 200-micron thick CsI detector using Monte Carlo simulations. Electronic noise was added as Gaussian noise as a

  2. A method of PSF generation for 3D brightfield deconvolution.

    Science.gov (United States)

    Tadrous, P J

    2010-02-01

    This paper addresses the problem of 3D deconvolution of through focus widefield microscope datasets (Z-stacks). One of the most difficult stages in brightfield deconvolution is finding the point spread function. A theoretically calculated point spread function (called a 'synthetic PSF' in this paper) requires foreknowledge of many system parameters and still gives only approximate results. A point spread function measured from a sub-resolution bead suffers from low signal-to-noise ratio, compounded in the brightfield setting (by contrast to fluorescence) by absorptive, refractive and dispersal effects. This paper describes a method of point spread function estimation based on measurements of a Z-stack through a thin sample. This Z-stack is deconvolved by an idealized point spread function derived from the same Z-stack to yield a point spread function of high signal-to-noise ratio that is also inherently tailored to the imaging system. The theory is validated by a practical experiment comparing the non-blind 3D deconvolution of the yeast Saccharomyces cerevisiae with the point spread function generated using the method presented in this paper (called the 'extracted PSF') to a synthetic point spread function. Restoration of both high- and low-contrast brightfield structures is achieved with fewer artefacts using the extracted point spread function obtained with this method. Furthermore the deconvolution progresses further (more iterations are allowed before the error function reaches its nadir) with the extracted point spread function compared to the synthetic point spread function indicating that the extracted point spread function is a better fit to the brightfield deconvolution model than the synthetic point spread function.

  3. Accurate evaluation of modulation transfer function using the Fourier shift theorem

    Science.gov (United States)

    Kim, Yong Gwon; Ryu, Yeunchul

    2017-12-01

    Accurate determination of the line spread function (LSF) on the basis of the edge processing algorithm in X-ray imaging systems is one of the most basic procedures for evaluating the performance of such systems. Extensive research has been focused on algorithms for the precise or fast measurement of the LSF in digital X-ray systems. Most of the standard methods for evaluating the performance of an imaging system are based on a fully digitalized radiographic system or a film-based system. However, images obtained by computed radiography (CR), which converts a captured analog signal into a digital image through an analog-to-digital converting scanner, show the combined characteristics of analog and digital imaging systems. Fundamentally, the characteristics of digital imaging systems differ substantially from those of film imaging systems because of their different methods of acquiring and displaying image data. In addition, a system with both analog and digital component has characteristics that differ from those of both digital and analog systems. In this research, we present a new modulation transfer function (MTF) that mimics the existing MTF in terms of measurement but satisfies existing standard protocols through modification of the hypothesis contents. In the case of the LSF and the point spread function measured with a CR system, the developed edge algorithm shows better performance than the conventional methods. We also demonstrate the usefulness of this method in an actual measurement with a CR digital X-ray imaging system.

  4. Spinal inhibition and motor function in adults with spastic cerebral palsy

    Science.gov (United States)

    Condliffe, E. G.; Jeffery, D. T.; Emery, D. J.

    2016-01-01

    Key points Abnormal activation of motoneurons in the spinal cord by sensory pathways is thought to contribute to impaired movement control and spasticity in individuals with cerebral palsy.Here we use single motor unit recordings to show how individual motoneurons in the spinal cord respond to sensory inputs in a group of participants with cerebral palsy having different degrees of motor dysfunction.In participants who had problems walking independently and required assistive devices such as wheelchairs, sensory pathways only excited motoneurons in the spinal cord.In contrast, in participants with cerebral palsy who walked independently for long distances, sensory inputs both inhibited and excited motoneurons in the spinal cord, similar to what we found in uninjured control participants.These findings demonstrate that in individuals with severe cerebral palsy, inhibitory control of motoneurons from sensory pathways is reduced and may contribute to motor dysfunction and spasticity. Abstract Reduced inhibition of spinal motoneurons by sensory pathways may contribute to heightened reflex activity, spasticity and impaired motor function in individuals with cerebral palsy (CP). To measure if the activation of inhibitory post‐synaptic potentials (IPSPs) by sensory inputs is reduced in CP, the tonic discharge rate of single motor units from the soleus muscle was plotted time‐locked to the occurrence of a sensory stimulation to produce peri‐stimulus frequencygrams (PSFs). Stimulation to the medial arch of the foot was used to activate cutaneomuscular afferents in 17 adults with bilateral spastic CP and 15 neurologically intact (NI) peers. Evidence of IPSP activation from the PSF profiles, namely a marked pause or reduction in motor unit firing rates at the onset of the cutaneomuscular reflex, was found in all NI participants but in only half of participants with CP. In the other half of the participants with CP, stimulation of cutaneomuscular afferents produced a PSF

  5. The role of off-focus radiation in scatter correction for dedicated cone beam breast CT.

    Science.gov (United States)

    Shi, Linxi; Vedantham, Srinivasan; Karellas, Andrew; Zhu, Lei

    2018-01-01

    Dedicated cone beam breast CT (CBBCT) suffers from x-ray scatter contamination. We aim to identify the source of the significant difference between the scatter distributions estimated by two recent methods proposed by our group and to investigate its effect on CBBCT image quality. We recently proposed two novel methods of scatter correction for CBBCT, using a library based (LB) technique and a forward projection (FP) model. Despite similar enhancement on CBBCT image qualities, these two methods obtain very different scatter distributions. We hypothesize that the off-focus radiation (OFR) is the contributor and results in nontrivial signals in x-ray projections, which is ignored in the scatter estimation via the LB method. Experiments using a thin wire test tool are designed to study the effect of OFR on CBBCT spatial resolution by measuring the point spread function (PSF) and the modulation transfer function (MTF). A narrow collimator setting is used to suppress the OFR-induced signals. In addition, "PSFs" and "MTFs" are measured on clinical CBBCT images obtained by the LB and FP methods using small calcifications as point sources. The improvement of spatial resolution achieved by suppressing OFR in the wire experiment as well as in the clinical study is quantified by the improvement ratios of PSFs and spatial frequencies at different MTF values. Our hypothesis that OFR causes the imaging difference between the FP and LB methods is verified if these ratios obtained from experimental and clinical data are consistent. In the wire experiment, the results show that suppression of OFR increases the maximum signal of the PSF by about 14% and reduces the full-width-at-half-maximum (FWHM) by about 12.0%. Similar improvement on spatial resolution is achieved by the FP method compared with the LB method in the patient study. The improvement ratios of spatial frequencies at different MTF values without OFR match very well in both studies at a level of around 16%, with an

  6. Functional Boxplots

    KAUST Repository

    Sun, Ying

    2011-01-01

    This article proposes an informative exploratory tool, the functional boxplot, for visualizing functional data, as well as its generalization, the enhanced functional boxplot. Based on the center outward ordering induced by band depth for functional data, the descriptive statistics of a functional boxplot are: the envelope of the 50% central region, the median curve, and the maximum non-outlying envelope. In addition, outliers can be detected in a functional boxplot by the 1.5 times the 50% central region empirical rule, analogous to the rule for classical boxplots. The construction of a functional boxplot is illustrated on a series of sea surface temperatures related to the El Niño phenomenon and its outlier detection performance is explored by simulations. As applications, the functional boxplot and enhanced functional boxplot are demonstrated on children growth data and spatio-temporal U.S. precipitation data for nine climatic regions, respectively. This article has supplementary material online. © 2011 American Statistical Association.

  7. Functionalized Calixpyrroles

    DEFF Research Database (Denmark)

    Vargas-Zúñiga, Gabriela; Sessler, Jonathan; Bähring, Steffen

    2016-01-01

    as the extraction and transport of anionic species and ion pairs including cesium halide and sulfate salts. It is divided into seven sections. The first section describes the synthetic methods employed to functionalized calix[4]pyrrole. The second section focuses on functionalized calix[4]pyrroles that display...... enhanced anion binding properties compared to the non-functionalized parent system, octamethylcalix[4]pyrrole. The use of functionalized calix[4]pyrroles containing a fluorescent group or functionalized calix[4]pyrroles as building blocks for the preparation of stimulus-responsive materials is discussed...... and the eventual development of therapeutics that function via the transport of anions across cell membranes, are discussed....

  8. A PUBLIC Ks -SELECTED CATALOG IN THE COSMOS/ULTRAVISTA FIELD: PHOTOMETRY, PHOTOMETRIC REDSHIFTS, AND STELLAR POPULATION PARAMETERS ,

    International Nuclear Information System (INIS)

    Muzzin, Adam; Franx, Marijn; Labbé, Ivo; Marchesini, Danilo; Stefanon, Mauro; Milvang-Jensen, Bo; Fynbo, J. P. U.; Dunlop, James S.; Brammer, Gabriel; Van Dokkum, Pieter

    2013-01-01

    We present a catalog covering 1.62 deg 2 of the COSMOS/UltraVISTA field with point-spread function (PSF) matched photometry in 30 photometric bands. The catalog covers the wavelength range 0.15-24 μm including the available GALEX, Subaru, Canada-France-Hawaii Telescope, VISTA, and Spitzer data. Catalog sources have been selected from the DR1 UltraVISTA K s band imaging that reaches a depth of K s,tot = 23.4 AB (90% completeness). The PSF-matched catalog is generated using position-dependent PSFs ensuring accurate colors across the entire field. Also included is a catalog of photometric redshifts (z phot ) for all galaxies computed with the EAZY code. Comparison with spectroscopy from the zCOSMOS 10k bright sample shows that up to z ∼ 1.5 the z phot are accurate to Δz/(1 + z) = 0.013, with a catastrophic outlier fraction of only 1.6%. The z phot also show good agreement with the z phot from the NEWFIRM Medium Band Survey out to z ∼ 3. A catalog of stellar masses and stellar population parameters for galaxies determined using the FAST spectral energy distribution fitting code is provided for all galaxies. Also included are rest-frame U – V and V – J colors, L 2800 and L IR . The UVJ color-color diagram confirms that the galaxy bi-modality is well-established out to z ∼ 2. Star-forming galaxies also obey a star-forming 'main sequence' out to z ∼ 2.5, and this sequence evolves in a manner consistent with previous measurements. The COSMOS/UltraVISTA K s -selected catalog covers a unique parameter space in both depth, area, and multi-wavelength coverage and promises to be a useful tool for studying the growth of the galaxy population out to z ∼ 3-4.

  9. The LBTI Fizeau imager - I. Fundamental gain in high-contrast imaging

    Science.gov (United States)

    Patru, F.; Esposito, S.; Puglisi, A.; Riccardi, A.; Pinna, E.; Arcidiacono, C.; Antichi, J.; Mennesson, B.; Defrère, D.; Hinz, P. M.; Hill, J. M.

    2017-12-01

    We show by numerical simulations a fundamental gain in contrast when combining coherently monochromatic light from two adaptive optics (AO) telescopes instead of using a single stand-alone AO telescope, assuming efficient control and acquisition systems at high speed. A contrast gain map is defined as the normalized point spread functions (PSFs) ratio of a single Large Binocular Telescope (LBT) aperture over the dual Large Binocular Telescope Interferometer (LBTI) aperture in Fizeau mode. The global gain averaged across the AO-corrected field of view is improved by a factor of 2 in contrast in long exposures and by a factor of 10 in contrast in short exposures (i.e. in exposures, respectively, longer or shorter than the coherence time). The fringed speckle halo in short exposures contains not only high-angular resolution information, as stated by speckle imaging and speckle interferometry, but also high-contrast imaging information. A high-gain zone is further produced in the valleys of the PSF formed by the dark Airy rings and/or the dark fringes. Earth rotation allows us to exploit various areas in the contrast gain map. A huge-contrast gain in narrow zones can be achieved when both a dark fringe and a dark ring overlap on to an exoplanet. Compared to a single 8-m LBT aperture, the 23-m LBTI Fizeau imager can provide a gain in sensitivity (by a factor of 4), a gain in angular resolution (by a factor of 3) and, as well, a gain in raw contrast (by a factor of 2-1000 varying over the AO-corrected field of view).

  10. The Demographics and Properties of Wide-Orbit, Planetary-Mass Companions from PSF Fitting of Spitzer/IRAC Images

    Science.gov (United States)

    Martinez, Raquel; Kraus, Adam L.

    2017-06-01

    Over the past decade, a growing population of planetary-mass companions ( 100 AU) from their host stars, challenging existing models of both star and planet formation. It is unclear whether these systems represent the low-mass extreme of stellar binary formation or the high-mass and wide-orbit extreme of planet formation theories, as various proposed formation pathways inadequately explain the physical and orbital aspects of these systems. Even so, determining which scenario best reproduces the observed characteristics of the PMCs will come once a statistically robust sample of directly-imaged PMCs are found and studied.We are developing an automated pipeline to search for wide-orbit PMCs to young stars in Spitzer/IRAC images. A Markov Chain Monte Carlo (MCMC) algorithm is the backbone of our novel point spread function (PSF) subtraction routine that efficiently creates and subtracts χ2-minimizing instrumental PSFs, simultaneously measuring astrometry and infrared photometry of these systems across the four IRAC channels (3.6 μm, 4.5 μm, 5.8 μm, and 8 μm). In this work, we present the results of a Spitzer/IRAC archival imaging study of 11 young, low-mass (0.044-0.88 M⊙ K3.5-M7.5) stars known to have faint, low-mass companions in 3 nearby star-forming regions (Chameleon, Taurus, and Upper Scorpius). We characterize the systems found to have low-mass companions with non-zero [I1] - [I4] colors, potentially signifying the presence of a circum(sub?)stellar disk. Plans for future pipeline improvements and paths forward will also be discussed. Once this computational foundation is optimized, the stage is set to quickly scour the nearby star-forming regions already imaged by Spitzer, identify potential candidates for further characterization with ground- or space-based telescopes, and increase the number of widely-separated PMCs known.

  11. Invited Article: Deep Impact instrument calibration.

    Science.gov (United States)

    Klaasen, Kenneth P; A'Hearn, Michael F; Baca, Michael; Delamere, Alan; Desnoyer, Mark; Farnham, Tony; Groussin, Olivier; Hampton, Donald; Ipatov, Sergei; Li, Jianyang; Lisse, Carey; Mastrodemos, Nickolaos; McLaughlin, Stephanie; Sunshine, Jessica; Thomas, Peter; Wellnitz, Dennis

    2008-09-01

    Calibration of NASA's Deep Impact spacecraft instruments allows reliable scientific interpretation of the images and spectra returned from comet Tempel 1. Calibrations of the four onboard remote sensing imaging instruments have been performed in the areas of geometric calibration, spatial resolution, spectral resolution, and radiometric response. Error sources such as noise (random, coherent, encoding, data compression), detector readout artifacts, scattered light, and radiation interactions have been quantified. The point spread functions (PSFs) of the medium resolution instrument and its twin impactor targeting sensor are near the theoretical minimum [ approximately 1.7 pixels full width at half maximum (FWHM)]. However, the high resolution instrument camera was found to be out of focus with a PSF FWHM of approximately 9 pixels. The charge coupled device (CCD) read noise is approximately 1 DN. Electrical cross-talk between the CCD detector quadrants is correctable to <2 DN. The IR spectrometer response nonlinearity is correctable to approximately 1%. Spectrometer read noise is approximately 2 DN. The variation in zero-exposure signal level with time and spectrometer temperature is not fully characterized; currently corrections are good to approximately 10 DN at best. Wavelength mapping onto the detector is known within 1 pixel; spectral lines have a FWHM of approximately 2 pixels. About 1% of the IR detector pixels behave badly and remain uncalibrated. The spectrometer exhibits a faint ghost image from reflection off a beamsplitter. Instrument absolute radiometric calibration accuracies were determined generally to <10% using star imaging. Flat-field calibration reduces pixel-to-pixel response differences to approximately 0.5% for the cameras and <2% for the spectrometer. A standard calibration image processing pipeline is used to produce archival image files for analysis by researchers.

  12. Quantifying colocalization of a conditionally active transcription factor FOXP3 in three-dimensional cellular space

    Science.gov (United States)

    Abraham, Thomas; Allan, Sarah E.; Levings, Megan K.

    2009-02-01

    Biological macromolecular interactions between proteins, transcription factors, DNA and other types of biomolecules, are fundamentally important to several cellular and biological processes. 3D Multi-channel confocal microscopy and colocalization analysis of fluorescent signals have proven to be invaluable tools for detecting such molecular interactions. The aim of this work was to quantify colocalization of the FOXP3 transcription factor in 3D cellular space generated from the confocal 3D image sets. 293T cells transfected with a conditionally active form of FOXP3 were stained for nuclei with Hoechst, for FOXP3 with anti-FOXP3 conjugated to PE, and 4-hydroxytamoxifen used as protein translocation and activation agent. Since the protein signal was weak and nonspecific intensity contributions were strong, it was difficult to perform colocalization analysis and estimate colocalization quantities. We performed 3D restoration by deconvolution method on the confocal images using experimentally measured point spread functions (PSFs) and subsequently a color shift correction. The deconvolution method eliminated nonspecific intensity contributions originating from PSF imposed by optical microscopy diffraction resolution limits and noise since these factors significantly affected colocalization analysis and quantification. Visual inspection of the deconvolved 3D image suggested that the FOXP3 molecules are predominantly colocalized within the nuclei although the fluorescent signals from FOXP3 molecules were also present in the cytoplasm. A close inspection of the scatter plot (colocalization map) and correlation quantities such as the Pearsons and colocalization coefficients showed that the fluorescent signals from the FOXP3 molecules and DNA are strongly correlated. In conclusion, our colocalization quantification approach confirms the preferential association of the FOXP3 molecules with the DNA despite the presence of fluorescent signals from the former one both in the

  13. Entire functions

    CERN Document Server

    Markushevich, A I

    1966-01-01

    Entire Functions focuses on complex numbers and the algebraic operations on them and the basic principles of mathematical analysis.The book first elaborates on the concept of an entire function, including the natural generalization of the concept of a polynomial and power series. The text then takes a look at the maximum absolute value and the order of an entire function, as well as calculations for the coefficients of power series representing a given function, use of integrals, and complex numbers. The publication elaborates on the zeros of an entire function and the fundamen

  14. Bacterial Preferences for Specific Soil Particle Size Fractions Revealed by Community Analyses

    Directory of Open Access Journals (Sweden)

    Michael Hemkemeyer

    2018-02-01

    Full Text Available Genetic fingerprinting demonstrated in previous studies that differently sized soil particle fractions (PSFs; clay, silt, and sand with particulate organic matter (POM harbor microbial communities that differ in structure, functional potentials and sensitivity to environmental conditions. To elucidate whether specific bacterial or archaeal taxa exhibit preference for specific PSFs, we examined the diversity of PCR-amplified 16S rRNA genes by high-throughput sequencing using total DNA extracted from three long-term fertilization variants (unfertilized, fertilized with minerals, and fertilized with animal manure of an agricultural loamy sand soil and their PSFs. The PSFs were obtained by gentle ultrasonic dispersion, wet sieving, and centrifugation. The abundance of bacterial taxa assigned to operational taxonomic units (OTUs differed less than 2.7% between unfractionated soil and soil based on combined PSFs. Across the three soil variants, no archaeal OTUs, but many bacterial OTUs, the latter representing 34–56% of all amplicon sequences, showed significant preferences for specific PSFs. The sand-sized fraction with POM was the preferred site for members of Bacteroidetes and Alphaproteobacteria, while Gemmatimonadales preferred coarse silt, Actinobacteria and Nitrosospira fine silt, and Planctomycetales clay. Firmicutes were depleted in the sand-sized fraction. In contrast, archaea, which represented 0.8% of all 16S rRNA gene sequences, showed only little preference for specific PSFs. We conclude that differently sized soil particles represent distinct microenvironments that support specific bacterial taxa and that these preferences could strongly contribute to the spatial heterogeneity and bacterial diversity found in soils.

  15. Bacterial Preferences for Specific Soil Particle Size Fractions Revealed by Community Analyses

    Science.gov (United States)

    Hemkemeyer, Michael; Dohrmann, Anja B.; Christensen, Bent T.; Tebbe, Christoph C.

    2018-01-01

    Genetic fingerprinting demonstrated in previous studies that differently sized soil particle fractions (PSFs; clay, silt, and sand with particulate organic matter (POM)) harbor microbial communities that differ in structure, functional potentials and sensitivity to environmental conditions. To elucidate whether specific bacterial or archaeal taxa exhibit preference for specific PSFs, we examined the diversity of PCR-amplified 16S rRNA genes by high-throughput sequencing using total DNA extracted from three long-term fertilization variants (unfertilized, fertilized with minerals, and fertilized with animal manure) of an agricultural loamy sand soil and their PSFs. The PSFs were obtained by gentle ultrasonic dispersion, wet sieving, and centrifugation. The abundance of bacterial taxa assigned to operational taxonomic units (OTUs) differed less than 2.7% between unfractionated soil and soil based on combined PSFs. Across the three soil variants, no archaeal OTUs, but many bacterial OTUs, the latter representing 34–56% of all amplicon sequences, showed significant preferences for specific PSFs. The sand-sized fraction with POM was the preferred site for members of Bacteroidetes and Alphaproteobacteria, while Gemmatimonadales preferred coarse silt, Actinobacteria and Nitrosospira fine silt, and Planctomycetales clay. Firmicutes were depleted in the sand-sized fraction. In contrast, archaea, which represented 0.8% of all 16S rRNA gene sequences, showed only little preference for specific PSFs. We conclude that differently sized soil particles represent distinct microenvironments that support specific bacterial taxa and that these preferences could strongly contribute to the spatial heterogeneity and bacterial diversity found in soils. PMID:29527192

  16. Single-pixel interior filling function approach for detecting and correcting errors in particle tracking.

    Science.gov (United States)

    Burov, Stanislav; Figliozzi, Patrick; Lin, Binhua; Rice, Stuart A; Scherer, Norbert F; Dinner, Aaron R

    2017-01-10

    We present a general method for detecting and correcting biases in the outputs of particle-tracking experiments. Our approach is based on the histogram of estimated positions within pixels, which we term the single-pixel interior filling function (SPIFF). We use the deviation of the SPIFF from a uniform distribution to test the veracity of tracking analyses from different algorithms. Unbiased SPIFFs correspond to uniform pixel filling, whereas biased ones exhibit pixel locking, in which the estimated particle positions concentrate toward the centers of pixels. Although pixel locking is a well-known phenomenon, we go beyond existing methods to show how the SPIFF can be used to correct errors. The key is that the SPIFF aggregates statistical information from many single-particle images and localizations that are gathered over time or across an ensemble, and this information augments the single-particle data. We explicitly consider two cases that give rise to significant errors in estimated particle locations: undersampling the point spread function due to small emitter size and intensity overlap of proximal objects. In these situations, we show how errors in positions can be corrected essentially completely with little added computational cost. Additional situations and applications to experimental data are explored in SI Appendix In the presence of experimental-like shot noise, the precision of the SPIFF-based correction achieves (and can even exceed) the unbiased Cramér-Rao lower bound. We expect the SPIFF approach to be useful in a wide range of localization applications, including single-molecule imaging and particle tracking, in fields ranging from biology to materials science to astronomy.

  17. Simple Demonstration of the Impact of Spherical Aberration on Optical Imaging

    Science.gov (United States)

    Escobar, Isabel; Saavedra, Genaro; Pons, Amparo; Martinez-Corral, Manuel

    2008-01-01

    We present an experiment, well adapted for students of introductory optics courses, for the visualization of the impact of spherical aberration in the point spread function of imaging systems. The demonstrations are based on the analogy between the point-spread function of spherically aberrated systems, and the defocused patterns of 1D slit-like…

  18. Functional analysis

    CERN Document Server

    Kantorovich, L V

    1982-01-01

    Functional Analysis examines trends in functional analysis as a mathematical discipline and the ever-increasing role played by its techniques in applications. The theory of topological vector spaces is emphasized, along with the applications of functional analysis to applied analysis. Some topics of functional analysis connected with applications to mathematical economics and control theory are also discussed. Comprised of 18 chapters, this book begins with an introduction to the elements of the theory of topological spaces, the theory of metric spaces, and the theory of abstract measure space

  19. Functionalized amphipols

    DEFF Research Database (Denmark)

    Della Pia, Eduardo Antonio; Hansen, Randi Westh; Zoonens, Manuela

    2014-01-01

    Amphipols are amphipathic polymers that stabilize membrane proteins isolated from their native membrane. They have been functionalized with various chemical groups in the past years for protein labeling and protein immobilization. This large toolbox of functionalized amphipols combined...... with their interesting physico-chemical properties give opportunities to selectively add multiple functionalities to membrane proteins and to tune them according to the needs. This unique combination of properties makes them one of the most versatile strategies available today for exploiting membrane proteins onto...... surfaces for various applications in synthetic biology. This review summarizes the properties of functionalized amphipols suitable for synthetic biology approaches....

  20. Cognitive Function

    Science.gov (United States)

    Because chemicals can adversely affect cognitive function in humans, considerable effort has been made to characterize their effects using animal models. Information from such models will be necessary to: evaluate whether chemicals identified as potentially neurotoxic by screenin...

  1. Functional unparsing

    DEFF Research Database (Denmark)

    Danvy, Olivier

    2000-01-01

    A string-formatting function such as printf in C seemingly requires dependent types, because its control string determines the rest of its arguments. Examples: formula here We show how changing the representation of the control string makes it possible to program printf in ML (which does not allow...... dependent types). The result is well typed and perceptibly more efficient than the corresponding library functions in Standard ML of New Jersey and in Caml....

  2. Functional Unparsing

    DEFF Research Database (Denmark)

    Danvy, Olivier

    1998-01-01

    A string-formatting function such as printf in C seemingly requires dependent types, because its control string determines the rest of its arguments. We show how changing the representation of the control string makes it possible to program printf in ML (which does not allow dependent types......). The result is well typed and perceptibly more efficient than the corresponding library functions in Standard ML of New Jersey and in Caml....

  3. Noninvasive image derived heart input function for CMRglc measurements in small animal slow infusion FDG PET studies

    Science.gov (United States)

    Xiong, Guoming; Cumming, Paul; Todica, Andrei; Hacker, Marcus; Bartenstein, Peter; Böning, Guido

    2012-12-01

    Absolute quantitation of the cerebral metabolic rate for glucose (CMRglc) can be obtained in positron emission tomography (PET) studies when serial measurements of the arterial [18F]-fluoro-deoxyglucose (FDG) input are available. Since this is not always practical in PET studies of rodents, there has been considerable interest in defining an image-derived input function (IDIF) by placing a volume of interest (VOI) within the left ventricle of the heart. However, spill-in arising from trapping of FDG in the myocardium often leads to progressive contamination of the IDIF, which propagates to underestimation of the magnitude of CMRglc. We therefore developed a novel, non-invasive method for correcting the IDIF without scaling to a blood sample. To this end, we first obtained serial arterial samples and dynamic FDG-PET data of the head and heart in a group of eight anaesthetized rats. We fitted a bi-exponential function to the serial measurements of the IDIF, and then used the linear graphical Gjedde-Patlak method to describe the accumulation in myocardium. We next estimated the magnitude of myocardial spill-in reaching the left ventricle VOI by assuming a Gaussian point-spread function, and corrected the measured IDIF for this estimated spill-in. Finally, we calculated parametric maps of CMRglc using the corrected IDIF, and for the sake of comparison, relative to serial blood sampling from the femoral artery. The uncorrected IDIF resulted in 20% underestimation of the magnitude of CMRglc relative to the gold standard arterial input method. However, there was no bias with the corrected IDIF, which was robust to the variable extent of myocardial tracer uptake, such that there was a very high correlation between individual CMRglc measurements using the corrected IDIF with gold-standard arterial input results. Based on simulation, we furthermore find that electrocardiogram-gating, i.e. ECG-gating is not necessary for IDIF quantitation using our approach.

  4. interval functions

    Directory of Open Access Journals (Sweden)

    J. A. Chatfield

    1978-01-01

    Full Text Available Suppose N is a Banach space of norm |•| and R is the set of real numbers. All integrals used are of the subdivision-refinement type. The main theorem [Theorem 3] gives a representation of TH where H is a function from R×R to N such that H(p+,p+, H(p,p+, H(p−,p−, and H(p−,p each exist for each p and T is a bounded linear operator on the space of all such functions H. In particular we show that TH=(I∫abfHdα+∑i=1∞[H(xi−1,xi−1+−H(xi−1+,xi−1+]β(xi−1+∑i=1∞[H(xi−,xi−H(xi−,xi−]Θ(xi−1,xiwhere each of α, β, and Θ depend only on T, α is of bounded variation, β and Θ are 0 except at a countable number of points, fH is a function from R to N depending on H and {xi}i=1∞ denotes the points P in [a,b]. for which [H(p,p+−H(p+,p+]≠0 or [H(p−,p−H(p−,p−]≠0. We also define an interior interval function integral and give a relationship between it and the standard interval function integral.

  5. Bessel functions

    CERN Document Server

    Nambudiripad, K B M

    2014-01-01

    After presenting the theory in engineers' language without the unfriendly abstraction of pure mathematics, several illustrative examples are discussed in great detail to see how the various functions of the Bessel family enter into the solution of technically important problems. Axisymmetric vibrations of a circular membrane, oscillations of a uniform chain, heat transfer in circular fins, buckling of columns of varying cross-section, vibrations of a circular plate and current density in a conductor of circular cross-section are considered. The problems are formulated purely from physical considerations (using, for example, Newton's law of motion, Fourier's law of heat conduction electromagnetic field equations, etc.) Infinite series expansions, recurrence relations, manipulation of expressions involving Bessel functions, orthogonality and expansion in Fourier-Bessel series are also covered in some detail. Some important topics such as asymptotic expansions, generating function and Sturm-Lioville theory are r...

  6. Algebraic functions

    CERN Document Server

    Bliss, Gilbert Ames

    1933-01-01

    This book, immediately striking for its conciseness, is one of the most remarkable works ever produced on the subject of algebraic functions and their integrals. The distinguishing feature of the book is its third chapter, on rational functions, which gives an extremely brief and clear account of the theory of divisors.... A very readable account is given of the topology of Riemann surfaces and of the general properties of abelian integrals. Abel's theorem is presented, with some simple applications. The inversion problem is studied for the cases of genus zero and genus unity. The chapter on t

  7. Functional neurosurgery

    African Journals Online (AJOL)

    term saving of money are the reasons why developing countries should be investing in functional neurosurgery units. Surgery for medical refractory epilepsy can save large amounts of money in the long run if one considers the cost of second and thirdline antiepileptic drugs and the associated morbidity of uncontrolled ...

  8. Functional hyposplenism.

    Science.gov (United States)

    Kirkineska, L; Perifanis, V; Vasiliadis, T

    2014-01-01

    Functional hyposplenism is a condition accompanying many diseases such as sickle cell disease, celiac disease, alcoholic liver disease, hepatic cirrhosis, lymphomas and autoimmune disorders. It is characterised mostly by defective immune responses against infectious agents, especially encapsulated organisms, since the spleen is thought to play an important role in the production and maturation of B-memory lymphocytes and other substances like opsonins, both of which are considered crucial elements of the immune system for fighting infections. It is also associated with thrombocytosis, which might lead to thromboembolic events. Functional hyposplenism is diagnosed by the presence of Howell-Jolly bodies and pitted erythrocytes in the peripheral blood smear, and by nuclear imaging modalities such as spleen scintigraphy with the use of Technetium-99m and/or spleen scintigraphy with the use of heat-damaged Technetium-99m labeled erythrocytes. Severe infections accompanying functional hyposplenism can lead to the overwhelming post infection syndrome, which can often be fatal. Identifying patients with functional hyposplenism is important because simple measures such as vaccination against common infective microorganisms (e.g. Streptococcus pneumonia, Neisseria meningitides and Haemophilous influenzae) and antibiotic therapy when needed are considered beneficial in diminishing the frequency and gravity of the infections accompanying the syndrome.

  9. Functional dyspepsia

    NARCIS (Netherlands)

    Kleibeuker, JH; Thijs, JC

    2004-01-01

    Purpose of review Functional dyspepsia is a common disorder, most of the time of unknown etiology and with variable pathophysiology. Therapy has been and still is largely empirical. Data from recent studies provide new clues for targeted therapy based on knowledge of etiology and pathophysiologic

  10. Bacterial Preferences for Specific Soil Particle Size Fractions Revealed by Community Analyses

    DEFF Research Database (Denmark)

    Hemkemeyer, Michael; Dohrmann, Anja B.; Christensen, Bent Tolstrup

    2018-01-01

    Genetic fingerprinting demonstrated in previous studies that differently sized soil particle fractions (PSFs; clay, silt, and sand with particulate organic matter (POM)) harbor microbial communities that differ in structure, functional potentials and sensitivity to environmental conditions....... To elucidate whether specific bacterial or archaeal taxa exhibit preference for specific PSFs, we examined the diversity of PCR-amplified 16S rRNA genes by high-throughput sequencing using total DNA extracted from three long-term fertilization variants (unfertilized, fertilized with minerals, and fertilized...

  11. Functional Credentials

    Directory of Open Access Journals (Sweden)

    Deuber Dominic

    2018-04-01

    Full Text Available A functional credential allows a user to anonymously prove possession of a set of attributes that fulfills a certain policy. The policies are arbitrary polynomially computable predicates that are evaluated over arbitrary attributes. The key feature of this primitive is the delegation of verification to third parties, called designated verifiers. The delegation protects the privacy of the policy: A designated verifier can verify that a user satisfies a certain policy without learning anything about the policy itself. We illustrate the usefulness of this property in different applications, including outsourced databases with access control. We present a new framework to construct functional credentials that does not require (non-interactive zero-knowledge proofs. This is important in settings where the statements are complex and thus the resulting zero-knowledge proofs are not efficient. Our construction is based on any predicate encryption scheme and the security relies on standard assumptions. A complexity analysis and an experimental evaluation confirm the practicality of our approach.

  12. Lung function

    International Nuclear Information System (INIS)

    Sorichter, S.

    2009-01-01

    The term lung function is often restricted to the assessment of volume time curves measured at the mouth. Spirometry includes the assessment of lung volumes which can be mobilised with the corresponding flow-volume curves. In addition, lung volumes that can not be mobilised, such as the residual volume, or only partially as FRC and TLC can be measured by body plethysmography combined with the determination of the airway resistance. Body plethysmography allows the correct positioning of forced breathing manoeuvres on the volume-axis, e.g. before and after pharmacotherapy. Adding the CO single breath transfer factor (T LCO ), which includes the measurement of the ventilated lung volume using He, enables a clear diagnosis of different obstructive, restrictive or mixed ventilatory defects with and without trapped air. Tests of reversibility and provocation, as well as the assessment of inspiratory mouth pressures (PI max , P 0.1 ) help to classify the underlying disorder and to clarify treatment strategies. For further information and to complete the diagnostic of disturbances of the ventilation, diffusion and/or perfusion (capillar-)arterial bloodgases at rest and under physical strain sometimes amended by ergospirometry are recommended. Ideally, lung function measurements are amended by radiological and nuclear medicine techniques. (orig.) [de

  13. Functional Angioplasty

    Directory of Open Access Journals (Sweden)

    Rohit Tewari

    2013-01-01

    Full Text Available Coronary angiography underestimates or overestimates lesion severity, but still remains the cornerstone in the decision making for revascularization for an overwhelming majority of interventional cardiologists. Guidelines recommend and endorse non invasive functional evaluation ought to precede revascularization. In real world practice, this is adopted in less than 50% of patients who go on to have some form of revascularization. Fractional flow reserve (FFR is the ratio of maximal blood flow in a stenotic coronary relative to maximal flow in the same vessel, were it normal. Being independent of changes in heart rate, BP or prior infarction; and take into account the contribution of collateral blood flow. It is a majorly specific index with a reasonably high sensitivity (88%, specificity (100%, positive predictive value (100%, and overall accuracy (93%. Whilst FFR provides objective determination of ischemia and helps select appropriate candidates for revascularization (for both CABG and PCI in to cath lab itself before intervention, whereas intravascular ultrasound/optical coherence tomography guidance in PCI can secure the procedure by optimizing stent expansion. Functional angioplasty simply is incorporating both intravascular ultrasound and FFR into our daily Intervention practices.

  14. Functional Myelography

    Energy Technology Data Exchange (ETDEWEB)

    Lee, S. R.; Park, S. K.; Kim, J. J. [Hanyang University College of Medicine, Seoul (Korea, Republic of); Jeon, H. J.; Jeon, H. S.; Kim, D. Y. [Gang Nam Hospital, Seoul (Korea, Republic of)

    1984-09-15

    Morphologic changes of spinal canal and dural sac during spinal movement (flexion-extension) were analysed and reported with the base of cross sectional anatomy, as early as 1942. After that, this movement was emphasized and used in myelography in many countries under the name of functional myelography, for accurate diagnosis of spinal stenosis as herniated disc, but nor used commonly in Korea. Authors analysed functional myelographic findings of 78 cases, 37 of normal and 41 of surgically confirmed herniated disc, to intend to confirm the necessity of spinal movement during myelography. The results were as follows; 1. In normal group, anterior border of dural sac is stright with flexion, but indented in extension at the level of intervertebral space and this indentation is less prominent at L5-S1. 2. In normal group with extension, posterior indentation of dural sac is more prominent at the level of intervertebral space than body, A-P diameter of dural sac is narrowed all the level of intervertebral space except L5-S1,and dural sac moved anteriorly (near to the posterior portion of spinal body or intervertebral space) at the level L5-S1 and all spinal body. 3. In disc patient, anterior indentation of dural sac is persist in both views (flexion and extension) and much more exaggerated with extension, but less prominent at L5-S1. 4. In herniated disc patient with extension, anterior movement of anterior dural border at the level of L5-S1 is much decreased than normal.

  15. Functional Myelography

    International Nuclear Information System (INIS)

    Lee, S. R.; Park, S. K.; Kim, J. J.; Jeon, H. J.; Jeon, H. S.; Kim, D. Y.

    1984-01-01

    Morphologic changes of spinal canal and dural sac during spinal movement (flexion-extension) were analysed and reported with the base of cross sectional anatomy, as early as 1942. After that, this movement was emphasized and used in myelography in many countries under the name of functional myelography, for accurate diagnosis of spinal stenosis as herniated disc, but nor used commonly in Korea. Authors analysed functional myelographic findings of 78 cases, 37 of normal and 41 of surgically confirmed herniated disc, to intend to confirm the necessity of spinal movement during myelography. The results were as follows; 1. In normal group, anterior border of dural sac is stright with flexion, but indented in extension at the level of intervertebral space and this indentation is less prominent at L5-S1. 2. In normal group with extension, posterior indentation of dural sac is more prominent at the level of intervertebral space than body, A-P diameter of dural sac is narrowed all the level of intervertebral space except L5-S1,and dural sac moved anteriorly (near to the posterior portion of spinal body or intervertebral space) at the level L5-S1 and all spinal body. 3. In disc patient, anterior indentation of dural sac is persist in both views (flexion and extension) and much more exaggerated with extension, but less prominent at L5-S1. 4. In herniated disc patient with extension, anterior movement of anterior dural border at the level of L5-S1 is much decreased than normal.

  16. Functional analysis

    CERN Document Server

    Kesavan, S

    2009-01-01

    The material presented in this book is suited for a first course in Functional Analysis which can be followed by Masters students. While covering all the standard material expected of such a course, efforts have been made to illustrate the use of various theorems via examples taken from differential equations and the calculus of variations, either through brief sections or through exercises. In fact, this book will be particularly useful for students who would like to pursue a research career in the applications of mathematics. The book includes a chapter on weak and weak topologies and their applications to the notions of reflexivity, separability and uniform convexity. The chapter on the Lebesgue spaces also presents the theory of one of the simplest classes of Sobolev spaces. The book includes a chapter on compact operators and the spectral theory for compact self-adjoint operators on a Hilbert space. Each chapter has large collection of exercises at the end. These illustrate the results of the text, show ...

  17. WE-DE-207B-05: Measuring Spatial Resolution in Digital Breast Tomosynthesis: Update of AAPM Task Group 245

    Energy Technology Data Exchange (ETDEWEB)

    Scaduto, DA; Hu, Y-H; Zhao, W [Stony Brook Medicine, Stony Brook, NY (United States); Goodsitt, M; Chan, H-P [University Michigan, Ann Arbor, MI (United States); Olafsdottir, H [Image Owl, 105 Reykjavik (Iceland); Das, M [University Houston, Houston, TX (United States); Fredenberg, E [Philips Healthcare, Solna (Sweden); Geiser, W [UT MD Anderson Cancer Center, Houston, TX (United States); Goodenough, D [The George Washington University, Washington, DC (United States); Heid, P [ARCADES, Marseille (France); Liu, B [Massachusetts General Hospital, Boston, MA (United States); Mainprize, J [Sunnybrook Health Sciences Centre, North York, ON (Canada); Reiser, I [The University of Chicago, Chicago, IL (United States); Van Engen, R [LRCB, Nijmegen (Netherlands); Varchena, V [CIRS Inc., Norfolk, VA (United States); Vecchio, S [I.M.S., Pontecchio Marconi (Italy); Glick, S [Food and Drug Administration, Silver Spring, MD (United States)

    2016-06-15

    Purpose: Spatial resolution in digital breast tomosynthesis (DBT) is affected by inherent/binned detector resolution, oblique entry of x-rays, and focal spot size/motion; the limited angular range further limits spatial resolution in the depth-direction. While DBT is being widely adopted clinically, imaging performance metrics and quality control protocols have not been standardized. AAPM Task Group 245 on Tomosynthesis Quality Control has been formed to address this deficiency. Methods: Methods of measuring spatial resolution are evaluated using two prototype quality control phantoms for DBT. Spatial resolution in the detector plane is measured in projection and reconstruction domains using edge-spread function (ESF), point-spread function (PSF) and modulation transfer function (MTF). Spatial resolution in the depth-direction and effective slice thickness are measured in the reconstruction domain using slice sensitivity profile (SSP) and artifact spread function (ASF). An oversampled PSF in the depth-direction is measured using a 50 µm angulated tungsten wire, from which the MTF is computed. Object-dependent PSF is derived and compared with ASF. Sensitivity of these measurements to phantom positioning, imaging conditions and reconstruction algorithms is evaluated. Results are compared from systems of varying acquisition geometry (9–25 projections over 15–60°). Dependence of measurements on feature size is investigated. Results: Measurements of spatial resolution using PSF and LSF are shown to depend on feature size; depth-direction spatial resolution measurements are shown to similarly depend on feature size for ASF, though deconvolution with an object function removes feature size-dependence. A slanted wire may be used to measure oversampled PSFs, from which MTFs may be computed for both in-plane and depth-direction resolution. Conclusion: Spatial resolution measured using PSF is object-independent with sufficiently small object; MTF is object

  18. Functional Kaolinite.

    Science.gov (United States)

    Detellier, Christian

    2018-01-04

    The world resources of all clays are extremely large. Among the various types of clays, the world mine production of kaolin in 2016 was 37.0 Mt, the largest mined clay. Kaolin is traditionally used in ceramics, refractories and as paper coating and filling. But kaolin, as it is demonstrated in this paper, has a bright potential for use in non-traditional, high value-added, applications. This is particularly true for its principal component: the mineral species kaolinite which has a chemical structure allowing its functionalization, leading to a variety of potential applications. Kaolinite is a layered 1 : 1 clay mineral, the layer being made of two different sheets, a tetrahedral silica sheet and an octahedral alumina sheet. Large dipole-dipole interactions, in addition to a network of H-bonds, link the siloxane surface of a layer to the aluminol surface of another layer, making intercalation of guest species in kaolinite challenging. There is however a limited number of molecular units (molecules or salts) that can directly intercalate in kaolinite to form "pre-intercalates". Once intercalated these molecular units can be exchanged by a large number and variety of guests, providing access to the interlayer space of kaolinite, and to its reactive aluminol internal surfaces. The intercalation of molecules of pharmacological interest showed the potential of kaolinite to act as a slow-releasing agent for drugs, and the intercalation of polymers resulted in the creation of intercalated nanocomposites. The intercalation of ionic liquids gave materials with ionic conductivity properties in the solid-state. Intercalates are however unstable in water. One needed to make these organo-inorgano nanohybrid materials resistant to hydrolysis and more thermally stable. The network of aluminol groups on the internal surfaces of kaolinite offers the opportunity to design and create controlled organo-inorgano nanohybrid materials, taking advantage of their reactivity, in

  19. Special functions & their applications

    CERN Document Server

    Lebedev, N N

    1972-01-01

    Famous Russian work discusses the application of cylinder functions and spherical harmonics; gamma function; probability integral and related functions; Airy functions; hyper-geometric functions; more. Translated by Richard Silverman.

  20. Functional Programming in R

    DEFF Research Database (Denmark)

    Mailund, Thomas

    Master functions and discover how to write functional programs in R. In this book, you'll make your functions pure by avoiding side-effects; you’ll write functions that manipulate other functions, and you’ll construct complex functions using simpler functions as building blocks. In Functional...... Programming in R, you’ll see how we can replace loops, which can have side-effects, with recursive functions that can more easily avoid them. In addition, the book covers why you shouldn't use recursion when loops are more efficient and how you can get the best of both worlds. Functional programming...... functions by combining simpler functions. You will: Write functions in R including infix operators and replacement functions Create higher order functions Pass functions to other functions and start using functions as data you can manipulate Use Filer, Map and Reduce functions to express the intent behind...

  1. Fast computation of far-field pulse-echo PSF of arbitrary arrays for large sparse 2-D ultrasound array design.

    Science.gov (United States)

    Li, Zhaohui; Chi, Cheng

    2018-03-01

    Large wideband two-dimensional (2-D) arrays are essential for high-resolution three-dimensional (3-D) ultrasound imaging. Since the tremendous element number of a full sampled large 2-D array is not affordable in any practical 3-D ultrasound imaging system, it is necessary to reduce the element number through sparse 2-D array design. Sparse array design requires that both the positions and weights of the array elements should be arbitrarily alterable. Hence a proper evaluation tool that can deal with arbitrary array is integral to optimizing the array structure and apodization function. It is known that pulse-echo point spread function (PSF) has been a common tool used to evaluate the performance of wideband arrays in ultrasound imaging all along, which also plays an important role in wideband ultrasound simulations. However, so far the conventional ultrasound simulation tools can only calculate pulse-echo PSF of arbitrary wideband arrays in the time domain because of the existence of nonuniform nodes in the spatial impulse response expressions, which obstructs their application of FFT to do fast computation of the time-domain convolutions. As a result, ultra-high time consumption of pulse-echo PSF computation of a large arbitrary wideband array hampers it to be taken as the evaluation tool by any stochastic optimization methods which need massive iterations in designing large sparse 2-D arrays. This paper aims to make available the pulse-echo PSF tool in designing large sparse 2-D arrays by proposing a fast computation method of far-field pulse-echo PSFs of arbitrary wideband arrays. In the paper, fast computation of wideband spatial impulse responses of a 2-D array is first realized in frequency domain by employing the nonuniform fast Fourier transform (NUFFT), under the point source assumption in far-field. On the basis of that, fast computation of time-domain convolutions is made possible by using FFT. In addition, a short inverse FFT (IFFT) is applied in

  2. Functional Training Revisited.

    Science.gov (United States)

    Siff, Mel C.

    2002-01-01

    Asserts that though functional training is vital in all sporting preparation, it is only one aspect of the overall process. The paper defines functional training; discusses facets of functionality, functionality and balancing drills, and functional training and periodization; and concludes that functionality is best defined in terms of the outcome…

  3. Functional Programming in R

    DEFF Research Database (Denmark)

    Mailund, Thomas

    2017-01-01

    Master functions and discover how to write functional programs in R. In this book, you'll make your functions pure by avoiding side-effects; you’ll write functions that manipulate other functions, and you’ll construct complex functions using simpler functions as building blocks. In Functional...... Programming in R, you’ll see how we can replace loops, which can have side-effects, with recursive functions that can more easily avoid them. In addition, the book covers why you shouldn't use recursion when loops are more efficient and how you can get the best of both worlds. Functional programming...

  4. 78 FR 13352 - Government-Owned Inventions; Availability for Licensing

    Science.gov (United States)

    2013-02-27

    ... deconvolution procedure that recovers images that have been blurred by a known point spread function. The.... Wilson RM. Nanodiamonds are promising quantum probes of living cells. Phys Today 2011 Aug;64(8):17. [doi...

  5. Impact of error management culture on knowledge performance in professional service firms

    Directory of Open Access Journals (Sweden)

    Tabea Scheel

    2014-01-01

    Full Text Available Knowledge is the most crucial resource of the 21st century. For professional service firms (PSFs, knowledge represents the input as well as the output, and thus the fundamental base for performance. As every organization, PSFs have to deal with errors – and how they do that indicates their error culture. Considering the positive potential of errors (e.g., innovation, error management culture is positively related to organizational performance. This longitudinal quantitative study investigates the impact of error management culture on knowledge performance in four waves. The study was conducted in 131 PSFs, i.e. tax accounting offices. As a standard quality management system (QMS was assumed to moderate the relationship between error management culture and knowledge performance, offices' ISO 9000 certification was assessed. Error management culture correlated positively with knowledge performance at a significant level and predicted knowledge performance one year later. While the ISO 9000 certification correlated positively with knowledge performance, its assumed moderation of the relationship between error management culture and knowledge performance was not consistent. The process-oriented QMS seems to function as facilitator for the more behavior-oriented error management culture. However, the benefit of ISO 9000 certification for tax accounting remains to be proven. Given the impact of error management culture on knowledge performance, PSFs should focus on actively promoting positive attitudes towards errors.

  6. Fully automated calculation of image-derived input function in simultaneous PET/MRI in a sheep model

    Energy Technology Data Exchange (ETDEWEB)

    Jochimsen, Thies H.; Zeisig, Vilia [Department of Nuclear Medicine, Leipzig University Hospital, Liebigstr. 18, Leipzig (Germany); Schulz, Jessica [Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstr. 1a, Leipzig, D-04103 (Germany); Werner, Peter; Patt, Marianne; Patt, Jörg [Department of Nuclear Medicine, Leipzig University Hospital, Liebigstr. 18, Leipzig (Germany); Dreyer, Antje Y. [Fraunhofer Institute of Cell Therapy and Immunology, Perlickstr. 1, Leipzig, D-04103 (Germany); Translational Centre for Regenerative Medicine, University Leipzig, Philipp-Rosenthal-Str. 55, Leipzig, D-04103 (Germany); Boltze, Johannes [Fraunhofer Institute of Cell Therapy and Immunology, Perlickstr. 1, Leipzig, D-04103 (Germany); Translational Centre for Regenerative Medicine, University Leipzig, Philipp-Rosenthal-Str. 55, Leipzig, D-04103 (Germany); Fraunhofer Research Institution of Marine Biotechnology and Institute for Medical and Marine Biotechnology, University of Lübeck, Lübeck (Germany); Barthel, Henryk; Sabri, Osama; Sattler, Bernhard [Department of Nuclear Medicine, Leipzig University Hospital, Liebigstr. 18, Leipzig (Germany)

    2016-02-13

    Obtaining the arterial input function (AIF) from image data in dynamic positron emission tomography (PET) examinations is a non-invasive alternative to arterial blood sampling. In simultaneous PET/magnetic resonance imaging (PET/MRI), high-resolution MRI angiographies can be used to define major arteries for correction of partial-volume effects (PVE) and point spread function (PSF) response in the PET data. The present study describes a fully automated method to obtain the image-derived input function (IDIF) in PET/MRI. Results are compared to those obtained by arterial blood sampling. To segment the trunk of the major arteries in the neck, a high-resolution time-of-flight MRI angiography was postprocessed by a vessel-enhancement filter based on the inertia tensor. Together with the measured PSF of the PET subsystem, the arterial mask was used for geometrical deconvolution, yielding the time-resolved activity concentration averaged over a major artery. The method was compared to manual arterial blood sampling at the hind leg of 21 sheep (animal stroke model) during measurement of blood flow with O15-water. Absolute quantification of activity concentration was compared after bolus passage during steady state, i.e., between 2.5- and 5-min post injection. Cerebral blood flow (CBF) values from blood sampling and IDIF were also compared. The cross-calibration factor obtained by comparing activity concentrations in blood samples and IDIF during steady state is 0.98 ± 0.10. In all examinations, the IDIF provided a much earlier and sharper bolus peak than in the time course of activity concentration obtained by arterial blood sampling. CBF using the IDIF was 22 % higher than CBF obtained by using the AIF yielded by blood sampling. The small deviation between arterial blood sampling and IDIF during steady state indicates that correction of PVE and PSF is possible with the method presented. The differences in bolus dynamics and, hence, CBF values can be explained by the

  7. [Psychological function in aging].

    Science.gov (United States)

    Wada, Kenji; Yamamoto, Mikie; Nakashima, Kenji

    2013-10-01

    Physical function was declined in aging as well as sensory function in human. Motor slowness and unbalance gait occur as well as decline of ability visual acuity and hearing let elderly people live in limited daily activity. Psychological functions are also thought to be decline in aging. In International Classification of Functioning, Disability and Health(ICF), psychological functions are classified into attention, memory, psychomotor, emotion, perception, thought, higher-level cognitive functions, language, calculation, sequencing complex movements, experience of self and time functions and unspecified functions. It is difficult to assess an individual psychological function itself, because some functions may affect each other and results of evaluations of a psychological function may not represent the meaning of the function. There were numerous reports on physical function in aging in a cross sectional or a longitudinal study design. In this article, we review changes of psychological function in aging.

  8. Generalized Probability Functions

    Directory of Open Access Journals (Sweden)

    Alexandre Souto Martinez

    2009-01-01

    Full Text Available From the integration of nonsymmetrical hyperboles, a one-parameter generalization of the logarithmic function is obtained. Inverting this function, one obtains the generalized exponential function. Motivated by the mathematical curiosity, we show that these generalized functions are suitable to generalize some probability density functions (pdfs. A very reliable rank distribution can be conveniently described by the generalized exponential function. Finally, we turn the attention to the generalization of one- and two-tail stretched exponential functions. We obtain, as particular cases, the generalized error function, the Zipf-Mandelbrot pdf, the generalized Gaussian and Laplace pdf. Their cumulative functions and moments were also obtained analytically.

  9. Functionality and homogeneity.

    NARCIS (Netherlands)

    2011-01-01

    Functionality and homogeneity are two of the five Sustainable Safety principles. The functionality principle aims for roads to have but one exclusive function and distinguishes between traffic function (flow) and access function (residence). The homogeneity principle aims at differences in mass,

  10. The spatial extent of polycyclic aromatic hydrocarbons emission in the Herbig star HD 179218

    Science.gov (United States)

    Taha, A. S.; Labadie, L.; Pantin, E.; Matter, A.; Alvarez, C.; Esquej, P.; Grellmann, R.; Rebolo, R.; Telesco, C.; Wolf, S.

    2018-04-01

    Aim. We investigate, in the mid-infrared, the spatial properties of the polycyclic aromatic hydrocarbons (PAHs) emission in the disk of HD 179218, an intermediate-mass Herbig star at 300 pc. Methods: We obtained mid-infrared images in the PAH-1, PAH-2 and Si-6 filters centered at 8.6, 11.3, and 12.5 μm, and N-band low-resolution spectra using CanariCam on the 10-m Gran Telescopio Canarias (GTC). We compared the point spread function (PSF) profiles measured in the PAH filters to the profile derived in the Si-6 filter, where the thermal continuum emission dominates. We performed radiative transfer modeling of the spectral energy distribution (SED) and produced synthetic images in the three filters to investigate different spatial scenarios. Results: Our data show that the disk emission is spatially resolved in the PAH-1 and PAH-2 filters, while unresolved in the Si-6 filter. Thanks to very good observing conditions, an average full width at half maximum (FWHM) of 0.232'', 0.280'' and 0.293'' is measured in the three filters, respectively. Gaussian disk fitting and quadratic subtraction of the science and calibrator PSFs suggests a lower-limit characteristic angular diameter of the emission of 100 mas, or 30 au. The photometric and spectroscopic results are compatible with previous findings. Our radiative transfer (RT) modeling of the continuum suggests that the resolved emission should result from PAH molecules on the disk atmosphere being UV-excited by the central star. Simple geometrical models of the PAH component compared to the underlying continuum point to a PAH emission uniformly extended out to the physical limits of the disk model. Furthermore, our RT best model of the continuum requires a negative exponent of the surface density power-law, in contrast with earlier modeling pointing to a positive exponent. Conclusions: We have spatially resolved - for the first time to our knowledge - the PAHs emission in the disk of HD 179218 and set constraints on its

  11. Fully 3D list-mode time-of-flight PET image reconstruction on GPUs using CUDA.

    Science.gov (United States)

    Cui, Jing-Yu; Pratx, Guillem; Prevrhal, Sven; Levin, Craig S

    2011-12-01

    -generated images for all cases. A list-mode ToF OSEM library was developed on the GPU-CUDA platform. Our studies show that the GPU reformulation is considerably faster than a single-threaded reference CPU method especially for ToF processing, while producing virtually identical images. This new method can be easily adapted to enable more advanced algorithms for high resolution PET reconstruction based on additional information such as depth of interaction (DoI), photon energy, and point spread functions (PSFs).

  12. Axial sidelobe reduction in single-photon 4Pi microscopy by Toraldo filters

    International Nuclear Information System (INIS)

    Martinex-Corral, M.; Pons, A.; Caballero, M.T.

    2002-01-01

    Full text: The 4Pi-confocal fluorescence microscope is a recently developed 3D imaging technique in which two opposing high-NA objectives are used for coherently illuminating and/or detecting the same point of the fluorescent sample. The interference process yields an intensity point spread function (PSF) with an extremely narrow axial core, but with very large axial sidelobes, which compromise the actual improvement in axial resolution. To overcome this problem we propose the use, in the illumination arm of the 4Pi-confocal microscope, of multiple-zones phase filters whose design is based on the Toraldo-design principle. Note that the Toraldo procedure allows to select at will the positions of the zeros of the PSF of an optical system. Then, what we propose here if to design a phase pupil filter such that the position of the first zero of the illumination axial PSF is close to the position of the maximum of the first axial sidelobe of the detection PSF. In the design procedure it is taken into account that: 1. The value of the parameter ε = λ exc /λ det which, in a single-photon fluorescent process, is the responsible for the different scales of the illumination and detection PSFs. 2. The Toraldo procedure was originally designed to control the position of zeros of the transverse PSF. In this case the procedure is adapted to the aim of controlling the position of zeros of the axial PSF. 3. Since 4Pi-confocal microscopes are only useful when built with high-NA objectives, the Toraldo principle is reformulated in terms of the nonparaxial diffraction theory. We show that by using Toraldo filters in the illumination part of a 4Pi-confocal microscope it is possible to obtain up to a 60% reduction of height of the axial sidelobe of the whole-system axial PSF. This fact permits to fully benefit the axial resolution from the strong narrowness of the central peak of the axial PSF, inherent to the 4Pi principle. Copyright (2002) Australian Society for Electron Microscopy

  13. The IAC Stripe 82 Legacy Project: a wide-area survey for faint surface brightness astronomy

    Science.gov (United States)

    Fliri, Jürgen; Trujillo, Ignacio

    2016-02-01

    We present new deep co-adds of data taken within Stripe 82 of the Sloan Digital Sky Survey (SDSS), especially stacked to reach the faintest surface brightness limits of this data set. Stripe 82 covers 275 ° ^2 within -50° ≤ RA ≤ +60° and -1.25° ≤ Dec. ≤ +1.25°. We discuss the steps of our reduction which puts special emphasis on preserving the characteristics of the background (sky + diffuse light) in the input images using a non-aggressive sky subtraction strategy. Our reduction reaches a limit of ˜28.5 mag arcsec-2 (3σ, 10 × 10 arcsec2) in the r band. The effective surface brightness limit (50 per cent completeness for exponential light distribution) lies at ˜ 25.5 mag arcsec-2. For point sources, we reach 50 per cent completeness limits (3σ level) of (24.2, 25.2, 24.7, 24.3, 23.0) mag in (u, g, r, I, z). This is between 1.7 and 2.0 mag deeper than the single-epoch SDSS releases. The co-adds show point spread functions (PSFs) with median full width at half-maximum values ranging from 1 arcsec in I and z to 1.3 arcsec in the u band. The imaging data are made publicly available at http://www.iac.es/proyecto/stripe82. The release includes deep co-adds and representations of the PSF for each field. Additionally, we provide object catalogues with stars and galaxies confidently separated until g ˜ 23 mag. The IAC Stripe 82 co-adds offer a rather unique possibility to study the low surface brightness Universe, exemplified by the discovery of stellar streams around NGC 0426 and NGC 0936. We also discuss further science cases like stellar haloes and disc truncations, low surface brightness galaxies, the intracluster light in galaxy clusters and the diffuse emission of Galactic dust known as Galactic Cirrus.

  14. CFHTLenS: improving the quality of photometric redshifts with precision photometry

    Science.gov (United States)

    Hildebrandt, H.; Erben, T.; Kuijken, K.; van Waerbeke, L.; Heymans, C.; Coupon, J.; Benjamin, J.; Bonnett, C.; Fu, L.; Hoekstra, H.; Kitching, T. D.; Mellier, Y.; Miller, L.; Velander, M.; Hudson, M. J.; Rowe, B. T. P.; Schrabback, T.; Semboloni, E.; Benítez, N.

    2012-04-01

    Here we present the results of various approaches to measure accurate colours and photometric redshifts (photo-z) from wide-field imaging data. We use data from the Canada-France-Hawaii Telescope Legacy Survey which have been re-processed by the Canada-France-Hawaii Telescope Lensing Survey (CFHTLenS) team in order to carry out a number of weak gravitational lensing studies. An emphasis is put on the correction of systematic effects in the photo-z arising from the different point spread functions (PSFs) in the five optical bands. Different ways of correcting these effects are discussed and the resulting photo-z accuracies are quantified by comparing the photo-z to large spectroscopic redshift (spec-z) data sets. Careful homogenization of the PSF between bands leads to increased overall accuracy of photo-z. The gain is particularly pronounced at fainter magnitudes where galaxies are smaller and flux measurements are affected more by PSF effects. We discuss ways of defining more secure subsamples of galaxies as well as a shape- and colour-based star-galaxy separation method, and we present redshift distributions for different magnitude limits. We also study possible re-calibrations of the photometric zero-points (ZPs) with the help of galaxies with known spec-z. We find that if PSF effects are properly taken into account, a re-calibration of the ZPs becomes much less important suggesting that previous such re-calibrations described in the literature could in fact be mostly corrections for PSF effects rather than corrections for real inaccuracies in the ZPs. The implications of this finding for future surveys like the Kilo Degree Survey (KiDS), Dark Energy Survey (DES), Large Synoptic Survey Telescope or Euclid are mixed. On the one hand, ZP re-calibrations with spec-z values might not be as accurate as previously thought. On the other hand, careful PSF homogenization might provide a way out and yield accurate, homogeneous photometry without the need for full

  15. Astrometry and orbits of Nix, Kerberos, AND Hydra

    Energy Technology Data Exchange (ETDEWEB)

    Buie, Marc W. [Southwest Research Institute, 1050 Walnut Street, Suite 300, Boulder, CO 80302 (United States); Grundy, William M. [Lowell Observatory, 1400 West Mars Hill Road, Flagstaff, AZ 86001 (United States); Tholen, David J., E-mail: buie@boulder.swri.edu, E-mail: grundy@lowell.edu, E-mail: tholen@ifa.hawaii.edu [Institute for Astronomy, University of Hawaii, 2680 Woodlawn Drive, Honolulu, HI 96822 (United States)

    2013-12-01

    We present new Hubble Space Telescope observations of three of Pluto's outer moons, Nix, Kerberos, and Hydra. This work revises previously published astrometry of Nix and Hydra from 2002 to 2003. New data from a four-month span during 2007 include observations designed to better measure the positions of Nix and Hydra. A third data set from 2010 also includes data on Nix and Hydra as well as some pre-discovery observations of Kerberos. The data were fitted using numerical point-spread function (PSF) fitting techniques to get accurate positions but also to remove the extended wings of the Pluto and Charon PSFs when working on these faint satellites. The resulting astrometric data were fitted with two-body Keplerian orbits that are useful for short-term predictions of the future positions of these satellites for stellar occultation and for guiding encounter planning for the upcoming New Horizons flyby of the Pluto system. The mutual inclinations of the satellites are all within 0.°2 of the plane of Charon's orbit. The periods for all continue to show that their orbits are near but distinct from integer period ratios relative to Charon. Based on our results, the period ratios are Hydra:Charon = 5.98094 ± 0.00001, Kerberos:Charon = 5.0392 ± 0.0003, and Nix:Charon = 3.89135 ± 0.00001. Based on period ratios alone, there is a trend of increased distance from an integer period ratio with decreasing distance from Charon. Our analysis shows that orbital uncertainties for Nix and Hydra are now low enough to permit useful stellar occultation predictions and for New Horizons encounter planning. In 2015 July, our orbits predict a position error of 60 km for Nix and 38 km for Hydra, well below other limiting errors that affect targeting. The orbit for Kerberos, however, still needs a lot of work as its uncertainty in 2015 is quite large at 22,000 km based on these data.

  16. Modeling astronomical adaptive optics performance with temporally filtered Wiener reconstruction of slope data.

    Science.gov (United States)

    Correia, Carlos M; Bond, Charlotte Z; Sauvage, Jean-François; Fusco, Thierry; Conan, Rodolphe; Wizinowich, Peter L

    2017-10-01

    We build on a long-standing tradition in astronomical adaptive optics (AO) of specifying performance metrics and error budgets using linear systems modeling in the spatial-frequency domain. Our goal is to provide a comprehensive tool for the calculation of error budgets in terms of residual temporally filtered phase power spectral densities and variances. In addition, the fast simulation of AO-corrected point spread functions (PSFs) provided by this method can be used as inputs for simulations of science observations with next-generation instruments and telescopes, in particular to predict post-coronagraphic contrast improvements for planet finder systems. We extend the previous results presented in Correia and Teixeira [J. Opt. Soc. Am. A31, 2763 (2014)JOAOD60740-323210.1364/JOSAA.31.002763] to the closed-loop case with predictive controllers and generalize the analytical modeling of Rigaut et al. [Proc. SPIE3353, 1038 (1998)PSISDG0277-786X10.1117/12.321649], Flicker [Technical Report (W. M. Keck Observatory, 2007)], and Jolissaint [J. Eur. Opt. Soc.5, 10055 (2010)1990-257310.2971/jeos.2010.10055]. We follow closely the developments of Ellerbroek [J. Opt. Soc. Am. A22, 310 (2005)JOAOD60740-323210.1364/JOSAA.22.000310] and propose the synthesis of a distributed Kalman filter to mitigate both aniso-servo-lag and aliasing errors while minimizing the overall residual variance. We discuss applications to (i) analytic AO-corrected PSF modeling in the spatial-frequency domain, (ii) post-coronagraphic contrast enhancement, (iii) filter optimization for real-time wavefront reconstruction, and (iv) PSF reconstruction from system telemetry. Under perfect knowledge of wind velocities, we show that ∼60  nm rms error reduction can be achieved with the distributed Kalman filter embodying antialiasing reconstructors on 10 m class high-order AO systems, leading to contrast improvement factors of up to three orders of magnitude at few λ/D separations (∼1-5λ/D) for a

  17. Investigating body function

    International Nuclear Information System (INIS)

    Monks, R.; Riley, A.L.M.

    1981-01-01

    This invention relates to the investigation of body function, especially small bowel function but also liver function, using bile acids and bile salts or their metabolic precursors labelled with radio isotopes and selenium or tellurium. (author)

  18. Random functions and turbulence

    CERN Document Server

    Panchev, S

    1971-01-01

    International Series of Monographs in Natural Philosophy, Volume 32: Random Functions and Turbulence focuses on the use of random functions as mathematical methods. The manuscript first offers information on the elements of the theory of random functions. Topics include determination of statistical moments by characteristic functions; functional transformations of random variables; multidimensional random variables with spherical symmetry; and random variables and distribution functions. The book then discusses random processes and random fields, including stationarity and ergodicity of random

  19. Every storage function is a state function

    NARCIS (Netherlands)

    Trentelman, H.L.; Willems, J.C.

    1997-01-01

    It is shown that for linear dynamical systems with quadratic supply rates, a storage function can always be written as a quadratic function of the state of an associated linear dynamical system. This dynamical system is obtained by combining the dynamics of the original system with the dynamics of

  20. The Interpretive Function

    DEFF Research Database (Denmark)

    Agerbo, Heidi

    2017-01-01

    Approximately a decade ago, it was suggested that a new function should be added to the lexicographical function theory: the interpretive function(1). However, hardly any research has been conducted into this function, and though it was only suggested that this new function was relevant to incorp......Approximately a decade ago, it was suggested that a new function should be added to the lexicographical function theory: the interpretive function(1). However, hardly any research has been conducted into this function, and though it was only suggested that this new function was relevant...... to incorporate into lexicographical theory, some scholars have since then assumed that this function exists(2), including the author of this contribution. In Agerbo (2016), I present arguments supporting the incorporation of the interpretive function into the function theory and suggest how non-linguistic signs...... can be treated in specific dictionary articles. However, in the current article, due to the results of recent research, I argue that the interpretive function should not be considered an individual main function. The interpretive function, contrary to some of its definitions, is not connected...

  1. Functional Object Analysis

    DEFF Research Database (Denmark)

    Raket, Lars Lau

    -effect formulations, where the observed functional signal is assumed to consist of both fixed and random functional effects. This thesis takes the initial steps toward the development of likelihood-based methodology for functional objects. We first consider analysis of functional data defined on high...

  2. Cryptographic Hash Functions

    DEFF Research Database (Denmark)

    Thomsen, Søren Steffen

    2009-01-01

    functions have received a huge amount of attention due to new attacks on widely used hash functions. This PhD thesis, having the title "Cryptographic Hash Functions", contains both a general description of cryptographic hash functions, including their applications and expected properties as well as some...

  3. Functional Programming in R

    DEFF Research Database (Denmark)

    Mailund, Thomas

    Master functions and discover how to write functional programs in R. In this book, you'll make your functions pure by avoiding side-effects; you’ll write functions that manipulate other functions, and you’ll construct complex functions using simpler functions as building blocks. In Functional...... Programming in R, you’ll see how we can replace loops, which can have side-effects, with recursive functions that can more easily avoid them. In addition, the book covers why you shouldn't use recursion when loops are more efficient and how you can get the best of both worlds. Functional programming...... is a style of programming, like object-oriented programming, but one that focuses on data transformations and calculations rather than objects and state. Where in object-oriented programming you model your programs by describing which states an object can be in and how methods will reveal or modify...

  4. The Interpretive Function

    DEFF Research Database (Denmark)

    Agerbo, Heidi

    2017-01-01

    to acting and therefore the only difference between reception and interpretation is that they work with different types of sign. However, the type of sign is not relevant for a function, or rather, it should not be a criterion for distinguishing between functions. The lemma selection for the communicative......Approximately a decade ago, it was suggested that a new function should be added to the lexicographical function theory: the interpretive function(1). However, hardly any research has been conducted into this function, and though it was only suggested that this new function was relevant...... to incorporate into lexicographical theory, some scholars have since then assumed that this function exists(2), including the author of this contribution. In Agerbo (2016), I present arguments supporting the incorporation of the interpretive function into the function theory and suggest how non-linguistic signs...

  5. Sampling functions for geophysics

    Science.gov (United States)

    Giacaglia, G. E. O.; Lunquist, C. A.

    1972-01-01

    A set of spherical sampling functions is defined such that they are related to spherical-harmonic functions in the same way that the sampling functions of information theory are related to sine and cosine functions. An orderly distribution of (N + 1) squared sampling points on a sphere is given, for which the (N + 1) squared spherical sampling functions span the same linear manifold as do the spherical-harmonic functions through degree N. The transformations between the spherical sampling functions and the spherical-harmonic functions are given by recurrence relations. The spherical sampling functions of two arguments are extended to three arguments and to nonspherical reference surfaces. Typical applications of this formalism to geophysical topics are sketched.

  6. Functionalized boron nitride nanotubes

    Science.gov (United States)

    Sainsbury, Toby; Ikuno, Takashi; Zettl, Alexander K

    2014-04-22

    A plasma treatment has been used to modify the surface of BNNTs. In one example, the surface of the BNNT has been modified using ammonia plasma to include amine functional groups. Amine functionalization allows BNNTs to be soluble in chloroform, which had not been possible previously. Further functionalization of amine-functionalized BNNTs with thiol-terminated organic molecules has also been demonstrated. Gold nanoparticles have been self-assembled at the surface of both amine- and thiol-functionalized boron nitride Nanotubes (BNNTs) in solution. This approach constitutes a basis for the preparation of highly functionalized BNNTs and for their utilization as nanoscale templates for assembly and integration with other nanoscale materials.

  7. A Blue Lagoon Function

    DEFF Research Database (Denmark)

    Markvorsen, Steen

    2007-01-01

    We consider a specific function of two variables whose graph surface resembles a blue lagoon. The function has a saddle point $p$, but when the function is restricted to any given straight line through $p$ it has a {\\em{strict local minimum}} along that line at $p$.......We consider a specific function of two variables whose graph surface resembles a blue lagoon. The function has a saddle point $p$, but when the function is restricted to any given straight line through $p$ it has a {\\em{strict local minimum}} along that line at $p$....

  8. Scattering function S (Q, w), correlation functions

    International Nuclear Information System (INIS)

    Binder, K.

    1978-01-01

    The following subjects are dealt with in this paper: 1) Two-Particle problem in quantum mechanics and inelastic scattering 2) The doubly differential cross section for many-particle systems 3) The van Hove transformation and the scattering funktion S (Q, w) 4) Relation between scattering functions and correlation functions 5) Examples: ideal gas, liquids 6) Differential cross section, sum rules, convolution approximation. (orig.) [de

  9. Functional Median Polish

    KAUST Repository

    Sun, Ying

    2012-08-03

    This article proposes functional median polish, an extension of univariate median polish, for one-way and two-way functional analysis of variance (ANOVA). The functional median polish estimates the functional grand effect and functional main factor effects based on functional medians in an additive functional ANOVA model assuming no interaction among factors. A functional rank test is used to assess whether the functional main factor effects are significant. The robustness of the functional median polish is demonstrated by comparing its performance with the traditional functional ANOVA fitted by means under different outlier models in simulation studies. The functional median polish is illustrated on various applications in climate science, including one-way and two-way ANOVA when functional data are either curves or images. Specifically, Canadian temperature data, U. S. precipitation observations and outputs of global and regional climate models are considered, which can facilitate the research on the close link between local climate and the occurrence or severity of some diseases and other threats to human health. © 2012 International Biometric Society.

  10. Ecological Functions of Landscapes

    Science.gov (United States)

    Kiryushin, V. I.

    2018-01-01

    Ecological functions of landscapes are considered a system of processes ensuring the development, preservation, and evolution of ecosystems and the biosphere as a whole. The concept of biogeocenosis can be considered a model that integrates biotic and environmental functions. The most general biogeocenotic functions specify the biodiversity, biotic links, self-organization, and evolution of ecosystems. Close interaction between biocenosis and the biotope (ecotope) is ensured by the continuous exchange of matter, energy, and information. Ecotope determines the biocenosis. The group of ecotopic functions includes atmospheric (gas exchange, heat exchange, hydroatmospheric, climate-forming), lithospheric (geodynamic, geophysical, and geochemical), hydrologic and hydrogeologic functions of landscape and ecotopic functions of soils. Bioecological functions emerge as a result of the biotope and ecotope interaction; these are the bioproductive, destructive, organoaccumulative, biochemical (gas, concentration, redox, biochemical, biopedological), pedogenetic, and energy functions

  11. Functionalized diamond nanoparticles

    KAUST Repository

    Beaujuge, Pierre M.

    2014-10-21

    A diamond nanoparticle can be functionalized with a substituted dienophile under ambient conditions, and in the absence of catalysts or additional reagents. The functionalization is thought to proceed through an addition reaction.

  12. Integrals of Bessel functions

    OpenAIRE

    Babusci, D.; Dattoli, G.; Germano, B.; Martinelli, M. R.; Ricci, P. E.

    2011-01-01

    We use the operator method to evaluate a class of integrals involving Bessel or Bessel-type functions. The technique we propose is based on the formal reduction of these family of functions to Gaussians.

  13. Adding functionality to garments

    CSIR Research Space (South Africa)

    Hunter, L

    2014-11-01

    Full Text Available various functionalities, such as retention of appearance, durability, comfort, handle and tailorability can be enhanced in garments. The tests used to assess and quantify the different functionalities are described....

  14. Smart hydrogel functional materials

    CERN Document Server

    Chu, Liang-Yin; Ju, Xiao-Jie

    2014-01-01

    This book systematically introduces smart hydrogel functional materials with the configurations ranging from hydrogels to microgels. It serves as an excellent reference for designing and fabricating artificial smart hydrogel functional materials.

  15. Functional Python programming

    CERN Document Server

    Lott, Steven

    2015-01-01

    This book is for developers who want to use Python to write programs that lean heavily on functional programming design patterns. You should be comfortable with Python programming, but no knowledge of functional programming paradigms is needed.

  16. The Measure of Human Error: Direct and Indirect Performance Shaping Factors

    Energy Technology Data Exchange (ETDEWEB)

    Ronald L. Boring; Candice D. Griffith; Jeffrey C. Joe

    2007-08-01

    The goal of performance shaping factors (PSFs) is to provide measures to account for human performance. PSFs fall into two categories—direct and indirect measures of human performance. While some PSFs such as “time to complete a task” are directly measurable, other PSFs, such as “fitness for duty,” can only be measured indirectly through other measures and PSFs, such as through fatigue measures. This paper explores the role of direct and indirect measures in human reliability analysis (HRA) and the implications that measurement theory has on analyses and applications using PSFs. The paper concludes with suggestions for maximizing the reliability and validity of PSFs.

  17. and chebyshev functions

    Directory of Open Access Journals (Sweden)

    Mohsen Razzaghi

    2000-01-01

    Full Text Available A direct method for finding the solution of variational problems using a hybrid function is discussed. The hybrid functions which consist of block-pulse functions plus Chebyshev polynomials are introduced. An operational matrix of integration and the integration of the cross product of two hybrid function vectors are presented and are utilized to reduce a variational problem to the solution of an algebraic equation. Illustrative examples are included to demonstrate the validity and applicability of the technique.

  18. Pseudolinear functions and optimization

    CERN Document Server

    Mishra, Shashi Kant

    2015-01-01

    Pseudolinear Functions and Optimization is the first book to focus exclusively on pseudolinear functions, a class of generalized convex functions. It discusses the properties, characterizations, and applications of pseudolinear functions in nonlinear optimization problems.The book describes the characterizations of solution sets of various optimization problems. It examines multiobjective pseudolinear, multiobjective fractional pseudolinear, static minmax pseudolinear, and static minmax fractional pseudolinear optimization problems and their results. The authors extend these results to locally

  19. Degenerate Euler zeta function

    OpenAIRE

    Kim, Taekyun

    2015-01-01

    Recently, T. Kim considered Euler zeta function which interpolates Euler polynomials at negative integer (see [3]). In this paper, we study degenerate Euler zeta function which is holomorphic function on complex s-plane associated with degenerate Euler polynomials at negative integers.

  20. Managing Functional Power

    DEFF Research Database (Denmark)

    Rosenstand, Claus Andreas Foss; Laursen, Per Kyed

    2013-01-01

    How does one manage functional power relations between leading functions in vision driven digital media creation, and this from idea to master during the creation cycle? Functional power is informal, and it is understood as roles, e.g. project manager, that provide opportunities to contribute...

  1. On Functional Calculus Estimates

    NARCIS (Netherlands)

    Schwenninger, F.L.

    2015-01-01

    This thesis presents various results within the field of operator theory that are formulated in estimates for functional calculi. Functional calculus is the general concept of defining operators of the form $f(A)$, where f is a function and $A$ is an operator, typically on a Banach space. Norm

  2. Automatic differentiation of functions

    International Nuclear Information System (INIS)

    Douglas, S.R.

    1990-06-01

    Automatic differentiation is a method of computing derivatives of functions to any order in any number of variables. The functions must be expressible as combinations of elementary functions. When evaluated at specific numerical points, the derivatives have no truncation error and are automatically found. The method is illustrated by simple examples. Source code in FORTRAN is provided

  3. Operations Between Functions

    DEFF Research Database (Denmark)

    Gardner, Richard J.; Kiderlen, Markus

    A structural theory of operations between real-valued (or extended-real-valued) functions on a nonempty subset A of Rn is initiated. It is shown, for example, that any operation ∗ on a cone of functions containing the constant functions, which is pointwise, positively homogeneous, monotonic...

  4. Generating generic functions

    NARCIS (Netherlands)

    Jeuring, J.T.; Rodriquez, A.; Smeding, G.

    2006-01-01

    We present an approach to the generation of generic functions from user-provided specifications. The specifications consist of the type of a generic function, examples of instances that it should “match” when specialized, and properties that the generic function should satisfy. We use the

  5. Phylogenetic molecular function annotation

    International Nuclear Information System (INIS)

    Engelhardt, Barbara E; Jordan, Michael I; Repo, Susanna T; Brenner, Steven E

    2009-01-01

    It is now easier to discover thousands of protein sequences in a new microbial genome than it is to biochemically characterize the specific activity of a single protein of unknown function. The molecular functions of protein sequences have typically been predicted using homology-based computational methods, which rely on the principle that homologous proteins share a similar function. However, some protein families include groups of proteins with different molecular functions. A phylogenetic approach for predicting molecular function (sometimes called 'phylogenomics') is an effective means to predict protein molecular function. These methods incorporate functional evidence from all members of a family that have functional characterizations using the evolutionary history of the protein family to make robust predictions for the uncharacterized proteins. However, they are often difficult to apply on a genome-wide scale because of the time-consuming step of reconstructing the phylogenies of each protein to be annotated. Our automated approach for function annotation using phylogeny, the SIFTER (Statistical Inference of Function Through Evolutionary Relationships) methodology, uses a statistical graphical model to compute the probabilities of molecular functions for unannotated proteins. Our benchmark tests showed that SIFTER provides accurate functional predictions on various protein families, outperforming other available methods.

  6. Expanding Pseudorandom Functions

    DEFF Research Database (Denmark)

    Damgård, Ivan Bjerre; Nielsen, Jesper Buus

    2002-01-01

    Given any weak pseudorandom function, we present a general and efficient technique transforming such a function to a new weak pseudorandom function with an arbitrary length output. This implies, among other things, an encryption mode for block ciphers. The mode is as efficient as known (and widely...

  7. Clinical functional MRI. Presurgical functional neuroimaging

    Energy Technology Data Exchange (ETDEWEB)

    Stippich, C. (ed.) [Heidelberg Univ. (Germany). Div. of Neuroradiology

    2007-07-01

    Functional magnetic resonance imaging (fMRI) permits noninvasive imaging of the ''human brain at work'' under physiological conditions. This is the first textbook on clinical fMRI. It is devoted to preoperative fMRI in patients with brain tumors and epilepsies, which are the most well-established clinical applications. By localizing and lateralizing specific brain functions, as well as epileptogenic zones, fMRI facilitates the selection of a safe treatment and the planning and performance of function-preserving neurosurgery. State of the art fMRI procedures are presented, with detailed consideration of the physiological and methodological background, imaging and data processing, normal and pathological findings, diagnostic possibilities and limitations, and other related techniques. All chapters are written by recognized experts in their fields, and the book is designed to be of value to beginners, trained clinicians and experts alike. (orig.)

  8. Nonparametric Transfer Function Models

    Science.gov (United States)

    Liu, Jun M.; Chen, Rong; Yao, Qiwei

    2009-01-01

    In this paper a class of nonparametric transfer function models is proposed to model nonlinear relationships between ‘input’ and ‘output’ time series. The transfer function is smooth with unknown functional forms, and the noise is assumed to be a stationary autoregressive-moving average (ARMA) process. The nonparametric transfer function is estimated jointly with the ARMA parameters. By modeling the correlation in the noise, the transfer function can be estimated more efficiently. The parsimonious ARMA structure improves the estimation efficiency in finite samples. The asymptotic properties of the estimators are investigated. The finite-sample properties are illustrated through simulations and one empirical example. PMID:20628584

  9. Implementing function spreadsheets

    DEFF Research Database (Denmark)

    Sestoft, Peter

    2008-01-01

    : that of turning an expression into a named function. Hence they proposed a way to define a function in terms of a worksheet with designated input and output cells; we shall call it a function sheet. The goal of our work is to develop implementations of function sheets and study their application to realistic...... examples. Therefore, we are also developing a simple yet comprehensive spreadsheet core implementation for experimentation with this technology. Here we report briefly on our experiments with function sheets as well as other uses of our spreadsheet core implementation....

  10. Transfer function combinations

    KAUST Repository

    Zhou, Liang

    2012-10-01

    Direct volume rendering has been an active area of research for over two decades. Transfer function design remains a difficult task since current methods, such as traditional 1D and 2D transfer functions, are not always effective for all data sets. Various 1D or 2D transfer function spaces have been proposed to improve classification exploiting different aspects, such as using the gradient magnitude for boundary location and statistical, occlusion, or size metrics. In this paper, we present a novel transfer function method which can provide more specificity for data classification by combining different transfer function spaces. In this work, a 2D transfer function can be combined with 1D transfer functions which improve the classification. Specifically, we use the traditional 2D scalar/gradient magnitude, 2D statistical, and 2D occlusion spectrum transfer functions and combine these with occlusion and/or size-based transfer functions to provide better specificity. We demonstrate the usefulness of the new method by comparing to the following previous techniques: 2D gradient magnitude, 2D occlusion spectrum, 2D statistical transfer functions and 2D size based transfer functions. © 2012 Elsevier Ltd.

  11. Operator Lipschitz functions

    Science.gov (United States)

    Aleksandrov, A. B.; Peller, V. V.

    2016-08-01

    The goal of this survey is a comprehensive study of operator Lipschitz functions. A continuous function f on the real line {R} is said to be operator Lipschitz if \\Vert f(A)-f(B)\\Vert≤slant{const}\\Vert A-B\\Vert for arbitrary self-adjoint operators A and B. Sufficient conditions and necessary conditions are given for operator Lipschitzness. The class of operator differentiable functions on {R} is also studied. Further, operator Lipschitz functions on closed subsets of the plane are considered, and the class of commutator Lipschitz functions on such subsets is introduced. An important role for the study of such classes of functions is played by double operator integrals and Schur multipliers. Bibliography: 77 titles.

  12. Cryptographic Hash Functions

    DEFF Research Database (Denmark)

    Gauravaram, Praveen; Knudsen, Lars Ramkilde

    2010-01-01

    Cryptographic hash functions are an important tool of cryptography and play a fundamental role in efficient and secure information processing. A hash function processes an arbitrary finite length input message to a fixed length output referred to as the hash value. As a security requirement, a hash...... important applications has also been analysed. This successful cryptanalysis of the standard hash functions has made National Institute of Standards and Technology (NIST), USA to initiate an international public competition to select the most secure and efficient hash function as the future hash function...... value should not serve as an image for two distinct input messages and it should be difficult to find the input message from a given hash value. Secure hash functions serve data integrity, non-repudiation and authenticity of the source in conjunction with the digital signature schemes. Keyed hash...

  13. Pair Correlation Function Integrals

    DEFF Research Database (Denmark)

    Wedberg, Nils Hejle Rasmus Ingemar; O'Connell, John P.; Peters, Günther H.J.

    2011-01-01

    We describe a method for extending radial distribution functions obtained from molecular simulations of pure and mixed molecular fluids to arbitrary distances. The method allows total correlation function integrals to be reliably calculated from simulations of relatively small systems. The long-d...... distribution function has structure beyond the sampling limit imposed by the system size, the integration is more reliable, and usually more accurate, than simple integral truncation.......We describe a method for extending radial distribution functions obtained from molecular simulations of pure and mixed molecular fluids to arbitrary distances. The method allows total correlation function integrals to be reliably calculated from simulations of relatively small systems. The long......, and J. Abildskov, Mol. Simul. 36, 1243 (2010); Fluid Phase Equilib. 302, 32 (2011)], but describe here its theoretical basis more thoroughly and derive long-distance approximations for the direct correlation functions. We describe the numerical implementation of the method in detail, and report...

  14. Time functions revisited

    Science.gov (United States)

    Fathi, Albert

    2015-07-01

    In this paper we revisit our joint work with Antonio Siconolfi on time functions. We will give a brief introduction to the subject. We will then show how to construct a Lipschitz time function in a simplified setting. We will end with a new result showing that the Aubry set is not an artifact of our proof of existence of time functions for stably causal manifolds.

  15. SPLINE, Spline Interpolation Function

    International Nuclear Information System (INIS)

    Allouard, Y.

    1977-01-01

    1 - Nature of physical problem solved: The problem is to obtain an interpolated function, as smooth as possible, that passes through given points. The derivatives of these functions are continuous up to the (2Q-1) order. The program consists of the following two subprograms: ASPLERQ. Transport of relations method for the spline functions of interpolation. SPLQ. Spline interpolation. 2 - Method of solution: The methods are described in the reference under item 10

  16. Functional Programming With Relations

    OpenAIRE

    Hutton, Graham

    1991-01-01

    While programming in a relational framework has much to offer over the functional style in terms of expressiveness, computing with relations is less efficient, and more semantically troublesome. In this paper we propose a novel blend of the functional and relational styles. We identify a class of "causal relations", which inherit some of the bi-directionality properties of relations, but retain the efficiency and semantic foundations of the functional style.

  17. Photon structure function

    International Nuclear Information System (INIS)

    Bardeen, W.A.

    1980-11-01

    Theoretical understanding of the photon structure function is reviewed. As an illustration of the pointlike component, the parton model is briefly discussed. However, the systematic study of the photon structure function is presented through the framework of the operator product expansion. Perturbative QCD is used as the theoretical basis for the calculation of leading contributions to the operator product expansion. The influence of higher order QCD effects on these results is discussed. Recent results for the polarized structure functions are discussed

  18. Normal Functions as a New Way of Defining Computable Functions

    Directory of Open Access Journals (Sweden)

    Leszek Dubiel

    2004-01-01

    Full Text Available Report sets new method of defining computable functions. This is formalization of traditional function descriptions, so it allows to define functions in very intuitive way. Discovery of Ackermann function proved that not all functions that can be easily computed can be so easily described with Hilbert's system of recursive functions. Normal functions lack this disadvantage.

  19. Normal Functions As A New Way Of Defining Computable Functions

    Directory of Open Access Journals (Sweden)

    Leszek Dubiel

    2004-01-01

    Full Text Available Report sets new method of defining computable functions. This is formalization of traditional function descriptions, so it allows to define functions in very intuitive way. Discovery of Ackermann function proved that not all functions that can be easily computed can be so easily described with Hilbert’s system of recursive functions. Normal functions lack this disadvantage.

  20. The gamma function

    CERN Document Server

    Artin, Emil

    2015-01-01

    This brief monograph on the gamma function was designed by the author to fill what he perceived as a gap in the literature of mathematics, which often treated the gamma function in a manner he described as both sketchy and overly complicated. Author Emil Artin, one of the twentieth century's leading mathematicians, wrote in his Preface to this book, ""I feel that this monograph will help to show that the gamma function can be thought of as one of the elementary functions, and that all of its basic properties can be established using elementary methods of the calculus."" Generations of teachers

  1. Coded Network Function Virtualization

    DEFF Research Database (Denmark)

    Al-Shuwaili, A.; Simone, O.; Kliewer, J.

    2016-01-01

    Network function virtualization (NFV) prescribes the instantiation of network functions on general-purpose network devices, such as servers and switches. While yielding a more flexible and cost-effective network architecture, NFV is potentially limited by the fact that commercial off-the-shelf ha......Network function virtualization (NFV) prescribes the instantiation of network functions on general-purpose network devices, such as servers and switches. While yielding a more flexible and cost-effective network architecture, NFV is potentially limited by the fact that commercial off...

  2. Perceptual Audio Hashing Functions

    Directory of Open Access Journals (Sweden)

    Emin Anarım

    2005-07-01

    Full Text Available Perceptual hash functions provide a tool for fast and reliable identification of content. We present new audio hash functions based on summarization of the time-frequency spectral characteristics of an audio document. The proposed hash functions are based on the periodicity series of the fundamental frequency and on singular-value description of the cepstral frequencies. They are found, on one hand, to perform very satisfactorily in identification and verification tests, and on the other hand, to be very resilient to a large variety of attacks. Moreover, we address the issue of security of hashes and propose a keying technique, and thereby a key-dependent hash function.

  3. Nonrespiratory lung function

    International Nuclear Information System (INIS)

    Isawa, Toyoharu

    1994-01-01

    The function of the lungs is primarily the function as a gas exchanger: the venous blood returning to the lungs is arterialized with oxygen in the lungs and the arterialized blood is sent back again to the peripheral tissues of the whole body to be utilized for metabolic oxygenation. Besides the gas exchanging function which we call ''respiratory lung function'' the lungs have functions that have little to do with gas exchange itself. We categorically call the latter function of the lungs as ''nonrespiratory lung function''. The lungs consist of the conductive airways, the gas exchanging units like the alveoli, and the interstitial space that surrounds the former two compartments. The interstitial space contains the blood and lymphatic capillaries, collagen and elastic fibers and cement substances. The conductive airways and the gas exchanging units are directly exposed to the atmosphere that contains various toxic and nontoxic gases, fume and biological or nonbiological particles. Because the conductive airways are equipped with defense mechanisms like mucociliary clearance or coughs to get rid of these toxic gases, particles or locally produced biological debris, we are usually free from being succumbed to ill effects of inhaled materials. By use of nuclear medicine techniques, we can now evaluate mucociliary clearance function, and other nonrespiratory lung functions as well in vivo

  4. Control functions in MFM

    DEFF Research Database (Denmark)

    Lind, Morten

    2011-01-01

    Multilevel Flow Modeling (MFM) has been proposed as a tool for representing goals and functions of complex industrial plants and suggested as a basis for reasoning about control situations. Lind presents an introduction to MFM but do not describe how control functions are used in the modeling....... The purpose of the present paper is to serve as a companion paper to this introduction by explaining the basic principles used in MFM for representation of control functions. A theoretical foundation for modeling control functions is presented and modeling examples are given for illustration....

  5. Subordination by convex functions

    Directory of Open Access Journals (Sweden)

    Rosihan M. Ali

    2006-01-01

    Full Text Available For a fixed analytic function g(z=z+∑n=2∞gnzn defined on the open unit disk and γ<1, let Tg(γ denote the class of all analytic functions f(z=z+∑n=2∞anzn satisfying ∑n=2∞|angn|≤1−γ. For functions in Tg(γ, a subordination result is derived involving the convolution with a normalized convex function. Our result includes as special cases several earlier works.

  6. Mapping Cognitive Function

    OpenAIRE

    Stufflebeam, Steven M.; Rosen, Bruce

    2007-01-01

    Cognitive functions are fundamental to being human. Although tremendous progress has been made in the science of cognition using neuroimaging, the clinical applications of neuroimaging are just beginning to be realized. A unifying theme of this chapter is the concept that a more complete understanding of cognition only comes through integration of multimodal structural and functional imaging technologies.

  7. Photon strength functions

    International Nuclear Information System (INIS)

    Bergqvist, I.

    1976-01-01

    Methods for extracting photon strength functions are briefly discussed. We follow the Brink-Axel approach to relate the strength functions to the giant resonances observed in photonuclear work and summarize the available data on the E1, E2 and M1 resonances. Some experimental and theoretical problems are outlined. (author)

  8. Marine functional food

    NARCIS (Netherlands)

    Luten, J.B.

    2009-01-01

    This book reviews the research on seafood and health, the use and quality aspects of marine lipids and seafood proteins as ingredients in functional foods and consumer acceptance of (marine) functional food. The first chapter covers novel merging areas where seafood may prevent disease and improve

  9. Functional Magnetic Resonance Imaging

    Science.gov (United States)

    Voos, Avery; Pelphrey, Kevin

    2013-01-01

    Functional magnetic resonance imaging (fMRI), with its excellent spatial resolution and ability to visualize networks of neuroanatomical structures involved in complex information processing, has become the dominant technique for the study of brain function and its development. The accessibility of in-vivo pediatric brain-imaging techniques…

  10. Who Researches Functional Literacy?

    Science.gov (United States)

    Shaw, Donita; Perry, Kristen H.; Ivanyuk, Lyudmyla; Tham, Sarah

    2017-01-01

    The purpose of our study was to discover who researches functional literacy. This study was situated within a larger systematic literature review. We searched seven electronic databases and identified 90 sources to answer our larger question regarding how functional literacy is defined and conceptualized as well as the specific question pertinent…

  11. Functional foods innovations

    Science.gov (United States)

    The aim of the Dairy and Functional Foods Research Unit (DFFRU), ERRC, ARS, USDA, is to improve human health and well being by developing functional food and consumer products that utilize milk and fruit and vegetable processing residues of specialty crops. Major research approaches involve: biotec...

  12. New Similarity Functions

    DEFF Research Database (Denmark)

    Yazdani, Hossein; Ortiz-Arroyo, Daniel; Kwasnicka, Halina

    2016-01-01

    In data science, there are important parameters that affect the accuracy of the algorithms used. Some of these parameters are: the type of data objects, the membership assignments, and distance or similarity functions. This paper discusses similarity functions as fundamental elements in membership...

  13. Functional polymer amphiphiles

    NARCIS (Netherlands)

    Loos, Femke de

    2009-01-01

    'The exact structures of large, biologically interesting molecules such as proteins are very important for the functions these molecules fulfill. In order to increase our understanding of the relationship between structure and function and to enhance the predictive power of theoretical models the

  14. Bandlimited Lipschitz functions

    OpenAIRE

    Lyubarskii, Yurii; Ortega Cerdà, Joaquim

    2014-01-01

    We study the space of bandlimited Lipschitz functions in one variable. In particular we provide a geometrical description of the natural interpolating and sampling sequences for this space. We also find a description of the trace of such functions to sequences of critical density in terms of a cancellation condition.

  15. Neurophysiology of functional imaging

    NARCIS (Netherlands)

    van Eijsden, Pieter; Hyder, Fahmeed; Rothman, Douglas L.; Shulman, Robert G.

    2009-01-01

    The successes of PET and fMRI in non-invasively localizing sensory functions had encouraged efforts to transform the subjective concepts of cognitive psychology into objective physical measures. The assumption was that mental functions could be decomposed into non-overlapping, context-independent

  16. Function spaces, 1

    CERN Document Server

    Pick, Luboš; John, Oldrich; Fucík, Svatopluk

    2012-01-01

    This is the first part of the second revised and extended edition of a well established monograph. It is an introduction to function spaces defined in terms of differentiability and integrability classes. It provides a catalogue of various spaces and benefits as a handbook for those who use function spaces to study other topics such as partial differential equations. Volum

  17. Functional Discourse Grammar

    NARCIS (Netherlands)

    Hengeveld, K.; Mackenzie, J.L.; Heine, B.; Narrog, H.

    2010-01-01

    Functional Discourse Grammar (FDG) is a typologically based structural-functional theory of language. It has a top-down organization to achieve psychological adequacy, and takes the Discourse Act as its basic unit of analysis to achieve pragmatic adequacy. Although itself strictly a model of

  18. The Functional C Experience

    NARCIS (Netherlands)

    Hartel, Pieter H.; Muller, Henk; Glaser, Hugh

    A functional programming language can be taught successfully as a First language, but if there is no follow up the students do not appreciate the functional approach. Following discussions concerning this issue at the 1995 FPLE conf. we decided to develop such a follow up by writing a book that

  19. Functional sensory symptoms

    NARCIS (Netherlands)

    Stone, J.; Vermeulen, M.

    2017-01-01

    Functional (psychogenic) sensory symptoms are those in which the patient genuinely experiences alteration or absence of normal sensation in the absence of neurologic disease. The hallmark of functional sensory symptoms is the presence of internal inconsistency revealing a pattern of symptoms

  20. A phased translation function

    International Nuclear Information System (INIS)

    Read, R.J.; Schierbeek, A.J.

    1988-01-01

    A phased translation function, which takes advantage of prior phase information to determine the position of an oriented mulecular replacement model, is examined. The function is the coefficient of correlation between the electron density computed with the prior phases and the electron density of the translated model, evaluated in reciprocal space as a Fourier transform. The correlation coefficient used in this work is closely related to an overlap function devised by Colman, Fehlhammer and Bartels. Tests with two protein structures, one of which was solved with the help of the phased translation function, show that little phase information is required to resolve the translation problem, and that the function is relatively insensitive to misorientation of the model. (orig.)

  1. Functional data analysis

    CERN Document Server

    Ramsay, J O

    1997-01-01

    Scientists today collect samples of curves and other functional observations. This monograph presents many ideas and techniques for such data. Included are expressions in the functional domain of such classics as linear regression, principal components analysis, linear modelling, and canonical correlation analysis, as well as specifically functional techniques such as curve registration and principal differential analysis. Data arising in real applications are used throughout for both motivation and illustration, showing how functional approaches allow us to see new things, especially by exploiting the smoothness of the processes generating the data. The data sets exemplify the wide scope of functional data analysis; they are drwan from growth analysis, meterology, biomechanics, equine science, economics, and medicine. The book presents novel statistical technology while keeping the mathematical level widely accessible. It is designed to appeal to students, to applied data analysts, and to experienced researc...

  2. On complex functions analyticity

    CERN Document Server

    Karavashkin, S B

    2002-01-01

    We analyse here the conventional definitions of analyticity and differentiability of functions of complex variable. We reveal the possibility to extend the conditions of analyticity and differentiability to the functions implementing the non-conformal mapping. On this basis we formulate more general definitions of analyticity and differentiability covering those conventional. We present some examples of such functions. By the example of a horizontal belt on a plane Z mapped non-conformally onto a crater-like harmonic vortex, we study the pattern of trajectory variation of a body motion in such field in case of field power function varying in time. We present the technique to solve the problems of such type with the help of dynamical functions of complex variable implementing the analytical non-conformal mapping

  3. A Functional HAZOP Methodology

    DEFF Research Database (Denmark)

    Liin, Netta; Lind, Morten; Jensen, Niels

    2010-01-01

    A HAZOP methodology is presented where a functional plant model assists in a goal oriented decomposition of the plant purpose into the means of achieving the purpose. This approach leads to nodes with simple functions from which the selection of process and deviation variables follow directly....... The functional HAZOP methodology lends itself directly for implementation into a computer aided reasoning tool to perform root cause and consequence analysis. Such a tool can facilitate finding causes and/or consequences far away from the site of the deviation. A functional HAZOP assistant is proposed...... and investigated in a HAZOP study of an industrial scale Indirect Vapor Recompression Distillation pilot Plant (IVaRDiP) at DTU-Chemical and Biochemical Engineering. The study shows that the functional HAZOP methodology provides a very efficient paradigm for facilitating HAZOP studies and for enabling reasoning...

  4. properties and luminosity functions

    Directory of Open Access Journals (Sweden)

    Hektor Monteiro

    2007-01-01

    Full Text Available In this article, we present an investigation of a sample of 1072 stars extracted from the Villanova Catalog of Spectroscopically Identified White Dwarfs (2005 on-line version, studying their distribution in the Galaxy, their physical properties and their luminosity functions. The distances and physical properties of the white dwarfs are determined through interpolation of their (B-V or (b-y colors in model grids. The solar position relative to the Galactic plane, luminosity function, as well as separate functions for each white dwarf spectral type are derived and discussed. We show that the binary fraction does not vary significantly as a function of distance from the Galactic disk out to 100 pc. We propose that the formation rates of DA and non-DAs have changed over time and/or that DAs evolve into non-DA types. The luminosity functions for DAs and DBs have peaks possibly related to a star burst event.

  5. Time Functions as Utilities

    Science.gov (United States)

    Minguzzi, E.

    2010-09-01

    Every time function on spacetime gives a (continuous) total preordering of the spacetime events which respects the notion of causal precedence. The problem of the existence of a (semi-)time function on spacetime and the problem of recovering the causal structure starting from the set of time functions are studied. It is pointed out that these problems have an analog in the field of microeconomics known as utility theory. In a chronological spacetime the semi-time functions correspond to the utilities for the chronological relation, while in a K-causal (stably causal) spacetime the time functions correspond to the utilities for the K + relation (Seifert’s relation). By exploiting this analogy, we are able to import some mathematical results, most notably Peleg’s and Levin’s theorems, to the spacetime framework. As a consequence, we prove that a K-causal (i.e. stably causal) spacetime admits a time function and that the time or temporal functions can be used to recover the K + (or Seifert) relation which indeed turns out to be the intersection of the time or temporal orderings. This result tells us in which circumstances it is possible to recover the chronological or causal relation starting from the set of time or temporal functions allowed by the spacetime. Moreover, it is proved that a chronological spacetime in which the closure of the causal relation is transitive (for instance a reflective spacetime) admits a semi-time function. Along the way a new proof avoiding smoothing techniques is given that the existence of a time function implies stable causality, and a new short proof of the equivalence between K-causality and stable causality is given which takes advantage of Levin’s theorem and smoothing techniques.

  6. Does the Feldenkrais Method make a difference? An investigation into the use of outcome measurement tools for evaluating changes in clients.

    Science.gov (United States)

    Connors, Karol Anne; Pile, Carolyn; Nichols, Margo Elaine

    2011-10-01

    Evidence-based practice confirms the need for outcome measures. Feldenkrais Method practitioners struggle to use such tools because of the broad range of applications of the Feldenkrais Method and the difficulty identifying suitable measurement tools. A pre/post-test design was used to investigate the use of three outcome measurement tools [Patient-specific Functional Scale (PSFS), Pain Outcome Profile (POP) and Short Form12v2 Health questionnaire (SF12v2)] for clients experiencing problems performing everyday functional tasks who attended Feldenkrais sessions. Eleven Feldenkrais practitioners submitted data on 48 clients. Changes were detected in the clients' ability to perform everyday tasks (PSFS improved 3.8 points, p Feldenkrais sessions. Crown Copyright © 2010. Published by Elsevier Ltd. All rights reserved.

  7. Mapping cognitive function.

    Science.gov (United States)

    Stufflebeam, Steven M; Rosen, Bruce R

    2007-11-01

    Cognitive functions are fundamental to being human. Although tremendous progress has been made in the science of cognition using neuroimaging, the clinical applications of neuroimaging are just beginning to be realized. This article focuses on selected technologies, analysis techniques, and applications that have, or will soon have, direct clinical impact. The authors discuss how cognition can be imaged using MR imaging, functional MR imaging, positron emission tomography, magnetoencephalography and electroencephalography, and MR imaging diffusion tensor imaging. A unifying theme of this article is the concept that a more complete understanding of cognition only comes through integration of multimodal structural and functional imaging technologies.

  8. Functional Amyloids in Reproduction.

    Science.gov (United States)

    Hewetson, Aveline; Do, Hoa Quynh; Myers, Caitlyn; Muthusubramanian, Archana; Sutton, Roger Bryan; Wylie, Benjamin J; Cornwall, Gail A

    2017-06-29

    Amyloids are traditionally considered pathological protein aggregates that play causative roles in neurodegenerative disease, diabetes and prionopathies. However, increasing evidence indicates that in many biological systems nonpathological amyloids are formed for functional purposes. In this review, we will specifically describe amyloids that carry out biological roles in sexual reproduction including the processes of gametogenesis, germline specification, sperm maturation and fertilization. Several of these functional amyloids are evolutionarily conserved across several taxa, including human, emphasizing the critical role amyloids perform in reproduction. Evidence will also be presented suggesting that, if altered, some functional amyloids may become pathological.

  9. Harmonic oscillator Green's function

    International Nuclear Information System (INIS)

    Macek, J.H.; Ovchinnikov, S.Yu.; Khrebtukov, D.B.

    2000-01-01

    The Green's function for the harmonic oscillator in three dimensions plays an important role in the theory of atomic collisions. One representation of low-energy ion-atom collisions involves harmonic oscillator potentials. A closed-form expression for the harmonic oscillator Green's function, needed to exploit this representation, is derived. This expression is similar to the expression for the Coulomb Green's function obtained by Hostler and Pratt. Calculations of electron distributions for a model system of ion-atom collisions are reported to illustrate the theory.

  10. Functionalized expanded porphyrins

    Science.gov (United States)

    Sessler, Jonathan L; Pantos, Patricia J

    2013-11-12

    Disclosed are functionalized expanded porphyrins that can be used as spectrometric sensors for high-valent actinide cations. The disclosed functionalized expanded porphyrins have the advantage over unfunctionalized systems in that they can be immobilized via covalent attachment to a solid support comprising an inorganic or organic polymer or other common substrates. Substrates comprising the disclosed functionalized expanded porphyrins are also disclosed. Further, disclosed are methods of making the disclosed compounds (immobilized and free), methods of using them as sensors to detect high valent actinides, devices that comprise the disclosed compounds, and kits.

  11. Polysheroidal periodic functions

    International Nuclear Information System (INIS)

    Truskova, N.F.

    1985-01-01

    Separation of variables in the Helmholtz N-dimensional (N≥4) equation in polyspheroidal coordinate systems leads to the necessity of solving equations going over into equations for polyspheroidal periodic functions used for solving the two-centre problem in quantum mechanics, the three-body problem with Coulomb interaction, etc. For these functions the expansions are derived in terms of the Jacobi polynomials and Bessel functions. Their basic properties, asymptotics are considered. The algorithm of their computer calculations is developed. The results of numerical calculations are given

  12. Choice probability generating functions

    DEFF Research Database (Denmark)

    Fosgerau, Mogens; McFadden, Daniel; Bierlaire, Michel

    2010-01-01

    This paper establishes that every random utility discrete choice model (RUM) has a representation that can be characterized by a choice-probability generating function (CPGF) with specific properties, and that every function with these specific properties is consistent with a RUM. The choice...... probabilities from the RUM are obtained from the gradient of the CPGF. Mixtures of RUM are characterized by logarithmic mixtures of their associated CPGF. The paper relates CPGF to multivariate extreme value distributions, and reviews and extends methods for constructing generating functions for applications...

  13. Skin barrier function

    DEFF Research Database (Denmark)

    2016-01-01

    barrier integrity, factors influencing the penetration of the skin, influence of wet work, and guidance for prevention and saving the barrier. Distinguished researchers have contributed to this book, providing a comprehensive and thorough overview of the skin barrier function. Researchers in the field...... on the subject. It covers new basic research on skin markers, including results on filaggrin and on methods for the assessment of the barrier function. Biological variation and aspects of skin barrier function restoration are discussed as well. Further sections are dedicated to clinical implications of skin...

  14. Lectures on Functional Analysis

    CERN Document Server

    Kurepa, Svetozar; Kraljević, Hrvoje

    1987-01-01

    This volume consists of a long monographic paper by J. Hoffmann-Jorgensen and a number of shorter research papers and survey articles covering different aspects of functional analysis and its application to probability theory and differential equations.

  15. Introduction to structure functions

    International Nuclear Information System (INIS)

    Kwiecinski, J.

    1996-07-01

    The theory of deep inelastic scattering structure functions is reviewed with an emphasis put on the QCD expectations of their behaviour in the region of small values of Bjorken parameter x. (author). 56 refs

  16. Reasoning about Function Objects

    Science.gov (United States)

    Nordio, Martin; Calcagno, Cristiano; Meyer, Bertrand; Müller, Peter; Tschannen, Julian

    Modern object-oriented languages support higher-order implementations through function objects such as delegates in C#, agents in Eiffel, or closures in Scala. Function objects bring a new level of abstraction to the object-oriented programming model, and require a comparable extension to specification and verification techniques. We introduce a verification methodology that extends function objects with auxiliary side-effect free (pure) methods to model logical artifacts: preconditions, postconditions and modifies clauses. These pure methods can be used to specify client code abstractly, that is, independently from specific instantiations of the function objects. To demonstrate the feasibility of our approach, we have implemented an automatic prover, which verifies several non-trivial examples.

  17. Functional Use Database (FUse)

    Data.gov (United States)

    U.S. Environmental Protection Agency — There are five different files for this dataset: 1. A dataset listing the reported functional uses of chemicals (FUse) 2. All 729 ToxPrint descriptors obtained from...

  18. Catalytic Functions of Standards

    NARCIS (Netherlands)

    K. Blind (Knut)

    2009-01-01

    textabstractThe three different areas and the examples have illustrated several catalytic functions of standards for innovation. First, the standardisation process reduces the time to market of inventions, research results and innovative technologies. Second, standards themselves promote the

  19. Contributing to Functionality

    DEFF Research Database (Denmark)

    Törpel, Bettina

    2006-01-01

    advocated in this paper, emerges in the specific dynamic interplay of actors, objectives, structures, practices and means. In this view, functionality is the result of creating, harnessing and inhabiting computer supported joint action spaces. The successful creation and further development of a computer......The objective of this paper is the design of computer supported joint action spaces. It is argued against a view of functionality as residing in computer applications. In such a view the creation of functionality is equivalent to the creation of computer applications. Functionality, in the view...... supported joint action space comprises a whole range of appropriate design contributions. The approach is illustrated by the example of the creation of the computer supported joint action space "exchange network of voluntary union educators". As part of the effort a group of participants created...

  20. Fundamentals of functional analysis

    CERN Document Server

    Farenick, Douglas

    2016-01-01

    This book provides a unique path for graduate or advanced undergraduate students to begin studying the rich subject of functional analysis with fewer prerequisites than is normally required. The text begins with a self-contained and highly efficient introduction to topology and measure theory, which focuses on the essential notions required for the study of functional analysis, and which are often buried within full-length overviews of the subjects. This is particularly useful for those in applied mathematics, engineering, or physics who need to have a firm grasp of functional analysis, but not necessarily some of the more abstruse aspects of topology and measure theory normally encountered. The reader is assumed to only have knowledge of basic real analysis, complex analysis, and algebra. The latter part of the text provides an outstanding treatment of Banach space theory and operator theory, covering topics not usually found together in other books on functional analysis. Written in a clear, concise manner,...

  1. Center for Functional Nanomaterials

    Data.gov (United States)

    Federal Laboratory Consortium — The Center for Functional Nanomaterials (CFN) explores the unique properties of materials and processes at the nanoscale. The CFN is a user-oriented research center...

  2. Assessment of splenic function

    NARCIS (Netherlands)

    de Porto, A.P.N.A.; Lammers, A.J.J.; Bennink, R.J.; ten Berge, R.J.M.; Speelman, P.; Hoekstra, J.B.L.

    2010-01-01

    Hyposplenic patients are at risk of overwhelming post-splenectomy infection (OPSI), which carries mortality of up to 70%. Therefore, preventive measures are warranted. However, patients with diminished splenic function are difficult to identify. In this review we discuss immunological,

  3. Haskell_#: Coordinating Functional Processes

    OpenAIRE

    Junior, Francisco Heron de Carvalho; Lins, Rafael Dueire

    2012-01-01

    This paper presents Haskell#, a coordination language targeted at the efficient implementation of parallel scientific applications on loosely coupled parallel architectures, using the functional language Haskell. Examples of applications, their implementation details and performance figures are presented.

  4. Normal Functioning Family

    Science.gov (United States)

    ... Spread the Word Shop AAP Find a Pediatrician Family Life Medical Home Family Dynamics Adoption & Foster Care ... Español Text Size Email Print Share Normal Functioning Family Page Content Article Body Is there any way ...

  5. Characterisation of Functional Surfaces

    DEFF Research Database (Denmark)

    Lonardo, P.M.; De Chiffre, Leonardo; Bruzzone, A.A.

    2004-01-01

    Characterisation of surfaces is of fundamental importance to control the manufacturing process and the functional performance of the part. Many applications concern contact and tribology problems, which include friction, wear and lubrication. This paper presents the techniques and instruments for...

  6. Safety performance functions.

    Science.gov (United States)

    2014-10-01

    This project developed safety performance functions for roadway segments and intersections for two-lane rural highways in : Pennsylvania. The statistical modeling methodology was consistent with that used in the first edition of the American : Associ...

  7. Smooth functions statistics

    International Nuclear Information System (INIS)

    Arnold, V.I.

    2006-03-01

    To describe the topological structure of a real smooth function one associates to it the graph, formed by the topological variety, whose points are the connected components of the level hypersurface of the function. For a Morse function, such a graph is a tree. Generically, it has T triple vertices, T + 2 endpoints, 2T + 2 vertices and 2T + 1 arrows. The main goal of the present paper is to study the statistics of the graphs, corresponding to T triple points: what is the growth rate of the number φ(T) of different graphs? Which part of these graphs is representable by the polynomial functions of corresponding degree? A generic polynomial of degree n has at most (n - 1) 2 critical points on R 2 , corresponding to 2T + 2 = (n - 1) 2 + 1, that is to T = 2k(k - 1) saddle-points for degree n = 2k

  8. Degenerate Gauss hypergeometric functions

    OpenAIRE

    Vidunas, Raimundas

    2004-01-01

    This is a study of terminating and ill-defined Gauss hypergeometric functions. Corresponding hypergeometric equations have a degenerate set of of 24 Kummer's solutions. We describe those solutions and relations between them.

  9. MATLAB: Creating Functions

    OpenAIRE

    2003-01-01

    sim tut Simulation Tutorial Interactive Media Element This interactive tutorial on MATLAB covers the following: Create M-files, scripts, and functions., Write HELP comments for the functions., Determine the order in which MATLAB chooses to execute entities with identical names.The interactions involve entering MATLAB instructions and observing the outcomes. Self-check questions are provided to help learners determine their level of understanding of the content presented. EC1...

  10. On Transcendental Functions

    Indian Academy of Sciences (India)

    Functions like loge X, eX, x real, and eZ loge Z, Z complex are very important in mathematics and physics. The re- sults in this article are not new, but they are presented in a very natural way. It is observed that eZ is the one and only one complex analytic extension of the real analytic function eX with the preservation of ...

  11. Production Functions Behaving Badly

    DEFF Research Database (Denmark)

    Fredholm, Thomas

    This paper reconsiders Anwar Shaikh's critique of the neoclassical theory of growth and distribution based on its use of aggregate production functions. This is done by reconstructing and extending Franklin M. Fisher's 1971 computer simulations, which Shaikh used to support his critique. Together...... with other recent extensions to Shaikh's seminal work, my results support and strengthen the evidence against the use of aggregate production functions....

  12. Applied functional analysis

    CERN Document Server

    Griffel, DH

    2002-01-01

    A stimulating introductory text, this volume examines many important applications of functional analysis to mechanics, fluid mechanics, diffusive growth, and approximation. Detailed enough to impart a thorough understanding, the text is also sufficiently straightforward for those unfamiliar with abstract analysis. Its four-part treatment begins with distribution theory and discussions of Green's functions. Essentially independent of the preceding material, the second and third parts deal with Banach spaces, Hilbert space, spectral theory, and variational techniques. The final part outlines the

  13. Inequalities for Humbert functions

    Directory of Open Access Journals (Sweden)

    Ayman Shehata

    2014-04-01

    Full Text Available This paper is motivated by an open problem of Luke’s theorem. We consider the problem of developing a unified point of view on the theory of inequalities of Humbert functions and of their general ratios are obtained. Some particular cases and refinements are given. Finally, we obtain some important results involving inequalities of Bessel and Whittaker’s functions as applications.

  14. Purely Functional Structured Programming

    OpenAIRE

    Obua, Steven

    2010-01-01

    The idea of functional programming has played a big role in shaping today's landscape of mainstream programming languages. Another concept that dominates the current programming style is Dijkstra's structured programming. Both concepts have been successfully married, for example in the programming language Scala. This paper proposes how the same can be achieved for structured programming and PURELY functional programming via the notion of LINEAR SCOPE. One advantage of this proposal is that m...

  15. Exponential and Logarithmic Functions

    OpenAIRE

    Todorova, Tamara

    2010-01-01

    Exponential functions find applications in economics in relation to growth and economic dynamics. In these fields, quite often the choice variable is time and economists are trying to determine the best timing for certain economic activities to take place. An exponential function is one in which the independent variable appears in the exponent. Very often that exponent is time. In highly mathematical courses, it is a truism that students learn by doing, not by reading. Tamara Todorova’s Pr...

  16. Functionally graded materials

    CERN Document Server

    Mahamood, Rasheedat Modupe

    2017-01-01

    This book presents the concept of functionally graded materials as well as their use and different fabrication processes. The authors describe the use of additive manufacturing technology for the production of very complex parts directly from the three dimension computer aided design of the part by adding material layer after layer. A case study is also presented in the book on the experimental analysis of functionally graded material using laser metal deposition process.

  17. Confinement from correlation functions

    Science.gov (United States)

    Fister, Leonard; Pawlowski, Jan M.

    2013-08-01

    We compute the Polyakov loop potential in Yang-Mills theory from the fully dressed primitively divergent correlation functions only. This is done in a variety of functional approaches ranging from functional renormalization group equations over Dyson-Schwinger equations to two-particle irreducible functionals. We present a confinement criterion that links the infrared behavior of propagators and vertices to the Polyakov loop expectation value. The present work extends the works of [J. Braun , Phys. Lett. B 684, 262 (2010)PYLBAJ0370-2693; F. Marhauser and J. M. Pawlowski, arXiv:0812.1144; J. Braun , Eur. Phys. J. C 70, 689 (2010)EPCFFB1434-6044] to general functional methods and sharpens the confinement criterion presented there. The computations are based on the thermal correlation functions in the Landau gauge calculated in [L. Fister and J. M. Pawlowski, arXiv:1112.5440; L. Fister and J. M. Pawlowski, arXiv:1112.5429; L. Fister, Ph.D. thesis, Heidelberg University, 2012].

  18. Functional balance tests

    Directory of Open Access Journals (Sweden)

    Parvin Raji

    2012-12-01

    Full Text Available Background and Aim: All activities of daily living need to balance control in static and dynamic movements. In recent years, a numerous increase can be seen in the functional balance assessment tools. Functional balance tests emphasize on static and dynamic balance, balance in weight transfer, the equilibrium response to the imbalances, and functional mobility. These standardized and available tests assess performance and require minimal or no equipment and short time to run. Functional balance is prerequisite for the most static and dynamic activities in daily life and needs sufficient interaction between sensory and motor systems. According to the critical role of balance in everyday life, and wide application of functional balance tests in the diagnosis and assessment of patients, a review of the functional balance tests was performed.Methods: The Google Scholar, PubMed, Science Direct, Scopus, Magiran, Iran Medex, and IranDoc databases were reviewed and the reliable and valid tests which were mostly used by Iranian researchers were assessed.Conclusion: It seems that Berg balance scale (BBS have been studied by Iranian and foreign researches more than the other tests. This test has high reliability and validity in elderly and in the most neurological disorders.

  19. Handbook of functional equations functional inequalities

    CERN Document Server

    2014-01-01

    As Richard Bellman has so elegantly stated at the Second International Conference on General Inequalities (Oberwolfach, 1978), “There are three reasons for the study of inequalities: practical, theoretical, and aesthetic.” On the aesthetic aspects, he said, “As has been pointed out, beauty is in the eye of the beholder. However, it is generally agreed that certain pieces of music, art, or mathematics are beautiful. There is an elegance to inequalities that makes them very attractive.” The content of the Handbook focuses mainly on both old and recent developments on approximate homomorphisms, on a relation between the Hardy–Hilbert and the Gabriel inequality, generalized Hardy–Hilbert type inequalities on multiple weighted Orlicz spaces, half-discrete Hilbert-type inequalities, on affine mappings, on contractive operators, on multiplicative Ostrowski and trapezoid inequalities, Ostrowski type inequalities for the  Riemann–Stieltjes integral, means and related functional inequalities, Weighted G...

  20. Functional integration over geometries

    International Nuclear Information System (INIS)

    Mottola, E.

    1995-01-01

    The geometric construction of the functional integral over coset spaces M/G is reviewed. The inner product on the cotangent space of infinitesimal deformations of M defines an invariant distance and volume form, or functional integration measure on the full configuration space. Then, by a simple change of coordinates parameterizing the gauge fiber G, the functional measure on the coset space M/G is deduced. This change of integration variables leads to a Jacobian which is entirely equivalent to the Faddeev--Popov determinant of the more traditional gauge fixed approach in non-abelian gauge theory. If the general construction is applied to the case where G is the group of coordinate reparameterizations of spacetime, the continuum functional integral over geometries, i.e. metrics modulo coordinate reparameterizations may be defined. The invariant functional integration measure is used to derive the trace anomaly and effective action for the conformal part of the metric in two and four dimensional spacetime. In two dimensions this approach generates the Polyakov--Liouville action of closed bosonic non-critical string theory. In four dimensions the corresponding effective action leads to novel conclusions on the importance of quantum effects in gravity in the far infrared, and in particular, a dramatic modification of the classical Einstein theory at cosmological distance scales, signaled first by the quantum instability of classical de Sitter spacetime. Finite volume scaling relations for the functional integral of quantum gravity in two and four dimensions are derived, and comparison with the discretized dynamical triangulation approach to the integration over geometries are discussed. Outstanding unsolved problems in both the continuum definition and the simplicial approach to the functional integral over geometries are highlighted

  1. A new measurement method for effective aperture of thick pinhole

    International Nuclear Information System (INIS)

    Xie Hongwei; Zhang Jianhua; Zhang Faqiang; Li Linbo; Qi Jianmin; Chen Jinchuan; Chen Dingyang

    2014-01-01

    The Lucy-Richardson super resolution image processing technique, combined with the introduced virtual point spread function (PSF), was used to develop a measurement method of the processing precision of the superfine thick pinhole aperture. The principles of the technique were based on the known ideal image and degraded image. After the restoration and reconstruction of the degraded image with the introduced virtual point spread function (PSF), the comparison is made between the reconstructed image and the ideal image to judge the correctness of the virtual point spread function (PSF). During this process, the simulation of the effects of the point spread function (PSF) upon the image reconstruction was carried out at first. As indicated by the simulation, the ideal point spread function (PSF) used in the image restoration and reconstruction could provide ideal results of the image reconstruction. However, in the case of relatively bigger size of the point spread function (PSF), the reconstructed image would be obtained smaller than the ideal image. Besides, related experiments were carried out on the cobalt radiation sources. In the experiments, the aperture of the shielded collimator to restrict and align the radiation source was known to be l.0 mm, the thick pinholes respectively 0.7 mm and 0.45 mm in aperture were used for the imaging of the ϕl mm radiation source, and the radiation image was recorded in imaging plates 0.05 mm × O.05 mm in spatial resolution. Based on the hypothesis that the processing precision of the thick pinhole fulfill the experiment requirements, the point spread function obtained from the simulated computation was introduced into the restoration and reconstruction of the recorded images. At the area with an intensity of 50%, the thick pinhole with 0.7 mm aperture could provide homogenous image of the radiation source. However, the thick pinhole with 0.45 mm aperture provided an elliptical image with a major-minor axis ratio of 5 : 3

  2. The Functions of Sleep

    Directory of Open Access Journals (Sweden)

    Samson Z Assefa

    2015-08-01

    Full Text Available Sleep is a ubiquitous component of animal life including birds and mammals. The exact function of sleep has been one of the mysteries of biology. A considerable number of theories have been put forward to explain the reason(s for the necessity of sleep. To date, while a great deal is known about what happens when animals sleep, there is no definitive comprehensive explanation as to the reason that sleep is an inevitable part of animal functioning. It is well known that sleep is a homeostatically regulated body process, and that prolonged sleep deprivation is fatal in animals. In this paper, we present some of the theories as to the functions of sleep and provide a review of some hypotheses as to the overall physiologic function of sleep. To better understand the purpose for sleeping, we review the effects of sleep deprivation on physical, neurocognitive and psychic function. A better understanding of the purpose for sleeping will be a great advance in our understanding of the nature of the animal kingdom, including our own.

  3. Sperm function test

    Directory of Open Access Journals (Sweden)

    Pankaj Talwar

    2015-01-01

    Full Text Available With absolute normal semen analysis parameters it may not be necessary to shift to specialized tests early but in cases with borderline parameters or with history of fertilization failure in past it becomes necessary to do a battery of tests to evaluate different parameters of spermatozoa. Various sperm function tests are proposed and endorsed by different researchers in addition to the routine evaluation of fertility. These tests detect function of a certain part of spermatozoon and give insight on the events in fertilization of the oocyte. The sperms need to get nutrition from the seminal plasma in the form of fructose and citrate (this can be assessed by fructose qualitative and quantitative estimation, citrate estimation. They should be protected from the bad effects of pus cells and reactive oxygen species (ROS (leukocyte detection test, ROS estimation. Their number should be in sufficient in terms of (count, structure normal to be able to fertilize eggs (semen morphology. Sperms should have intact and functioning membrane to survive harsh environment of vagina and uterine fluids (vitality and hypo-osmotic swelling test, should have good mitochondrial function to be able to provide energy (mitochondrial activity index test. They should also have satisfactory acrosome function to be able to burrow a hole in zona pellucida (acrosome intactness test, zona penetration test. Finally, they should have properly packed DNA in the nucleus to be able to transfer the male genes (nuclear chromatic decondensation test to the oocyte during fertilization.

  4. Renal Function in Hypothyroidism

    International Nuclear Information System (INIS)

    Khalid, S.; Khalid, M; Elfaki, M.; Hassan, N.; Suliman, S.M.

    2007-01-01

    Background Hypothyroidism induces significant changes in the function of organ systems such as the heart, muscles and brain. Renal function is also influenced by thyroid status. Physiological effects include changes in water and electrolyte metabolism, notably hyponatremia, and reliable alterations of renal hemodynamics, including decrements in renal blood flow, renal plasma flow, glomerular filtration rate (GFR). Objective Renal function is profoundly influenced by thyroid status; the purpose of the present study was to determine the relationship between renal function and thyroid status of patients with hypothyroidism. Design and Patients In 5 patients with primary hypothyroidism and control group renal functions are measured by serum creatinine and glomerular filtration rate (GFR) using modified in diet renal disease (MDRD) formula. Result In hypothyroidism, mean serum creatinine increased and mean estimated GFR decreased, compared to the control group mean serum creatinine decreased and mean estimated GFR Increased. The hypothyroid patients showed elevated serum creatinine levels (> 1.1mg/dl) compared to control group (p value .000). In patients mean estimated GFR decreased, compared to mean estimated GFR increased in the control group (p value= .002).

  5. Renal Function in Hypothyroidism

    International Nuclear Information System (INIS)

    Khalid, A. S; Ahmed, M.I; Elfaki, H.M; Hassan, N.; Suliman, S. M.

    2006-12-01

    Background hypothyroidism induces significant changes in the function of organ systems such as the heart, muscles and brain. Renal function is also influenced by thyroid status. Physiological effects include changes in water and electrolyte metabolism, notably hyponatraemia, and reliable alterations of renal hemodynamics, including decrements in renal blood flow, renal plasma flow, glomerular filtration rate (GFR). Objective renal function is profoundly influenced by thyroid status, the purpose of the present study was to determine the relationship between renal function and thyroid status of patients with hypothyroidism. Design and patients in 5 patients with primary hypothyroidism and control group renal functions are measured by serum creatinine and glomerular filtration rate(GFR) using modified in diet renal disease (MDRD) formula. Result in hypothyroidism, mean serum creatinine increased and mean estimated GFR decreased, compared to the control group mean serum creatinine decreased and mean estimated GFR increased. The hypothyroid patients showed elevated serum creatinine levels(>1.1 mg/d1) compared to control group (p value= 000). In patients mean estimated GFR increased in the control group (p value=.002).Conclusion thus the kidney, in addition to the brain, heart and muscle, is an important target of the action of thyroid hormones.(Author)

  6. Histamine and astrocyte function.

    Science.gov (United States)

    Jurič, Damijana M; Kržan, Mojca; Lipnik-Stangelj, Metoda

    2016-09-01

    Astrocytes support the brain through numerous functional interactions in health and disease. The recent advances in our knowledge of astrocyte involvement in various neurological disorders raised up several questions about their role and functioning in the central nervous system. From the evidence discussed in this review, we show that histamine importantly influences the main astrocytic activities such as ion homeostasis, energy metabolism, neurotransmitter clearance, neurotrophic activity and immune response. These processes are mediated through at least three histamine receptor subtypes, H1, H2 and H3, expressed on the astrocyte surface. Thus, we recognize histamine as an important player in the modulation of astrocytic functions that deserves further considerations in exploring involvement of astrocytes in neurological disorders. Copyright © 2016 Elsevier Ltd. All rights reserved.

  7. Functional studies using NMR

    International Nuclear Information System (INIS)

    McCready, V.R.; Leach, M.O.; Sutton; Ell, P.

    1986-01-01

    The object of this book is to discuss and evaluate an area of Nuclear Magnetic Resonance which to date has been less emphasized than it might be, namely the use of NMR for functional studies. The book commences with a discussion of the areas in which the NMR techniques might be needed due to deficiencies in other techniques. The physics of NMR especially relating to functional measurement are then explained. Technical factors in producing functional images are discussed and the use of paramagnetic substances for carrying out flow studies are detailed. Particular attention is paid to specific studies in the various organs. The book ends with a survey of imaging in each organ and the relation of NMR images to other techniques such as ultrasound, nuclear medicine and X-rays

  8. Tendon functional extracellular matrix.

    Science.gov (United States)

    Screen, Hazel R C; Berk, David E; Kadler, Karl E; Ramirez, Francesco; Young, Marian F

    2015-06-01

    This article is one of a series, summarizing views expressed at the Orthopaedic Research Society New Frontiers in Tendon Research Conference. This particular article reviews the three workshops held under the "Functional Extracellular Matrix" stream. The workshops focused on the roles of the tendon extracellular matrix, such as performing the mechanical functions of tendon, creating the local cell environment, and providing cellular cues. Tendon is a complex network of matrix and cells, and its biological functions are influenced by widely varying extrinsic and intrinsic factors such as age, nutrition, exercise levels, and biomechanics. Consequently, tendon adapts dynamically during development, aging, and injury. The workshop discussions identified research directions associated with understanding cell-matrix interactions to be of prime importance for developing novel strategies to target tendon healing or repair. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.

  9. Protein Functionalized Nanodiamond Arrays

    Directory of Open Access Journals (Sweden)

    Liu YL

    2010-01-01

    Full Text Available Abstract Various nanoscale elements are currently being explored for bio-applications, such as in bio-images, bio-detection, and bio-sensors. Among them, nanodiamonds possess remarkable features such as low bio-cytotoxicity, good optical property in fluorescent and Raman spectra, and good photostability for bio-applications. In this work, we devise techniques to position functionalized nanodiamonds on self-assembled monolayer (SAMs arrays adsorbed on silicon and ITO substrates surface using electron beam lithography techniques. The nanodiamond arrays were functionalized with lysozyme to target a certain biomolecule or protein specifically. The optical properties of the nanodiamond-protein complex arrays were characterized by a high throughput confocal microscope. The synthesized nanodiamond-lysozyme complex arrays were found to still retain their functionality in interacting with E. coli.

  10. Ghrelin and Functional Dyspepsia

    Directory of Open Access Journals (Sweden)

    Takashi Akamizu

    2010-01-01

    Full Text Available The majority of patients with dyspepsia have no identifiable cause of their disease, leading to a diagnosis of functional dyspepsia (FD. While a number of different factors affect gut activity, components of the nervous and endocrine systems are essential for normal gut function. Communication between the brain and gut occurs via direct neural connections or endocrine signaling events. Ghrelin, a peptide produced by the stomach, affects gastric motility/emptying and secretion, suggesting it may play a pathophysiological role in FD. It is also possible that the functional abnormalities in FD may affect ghrelin production in the stomach. Plasma ghrelin levels are reported to be altered in FD, correlating with FD symptom score. Furthermore, some patients with FD suffer from anorexia with body-weight loss. As ghrelin increases gastric emptying and promotes feeding, ghrelin therapy may be a new approach to the treatment of FD.

  11. Spaces of continuous functions

    CERN Document Server

    Groenewegen, G L M

    2016-01-01

    The space C(X) of all continuous functions on a compact space X carries the structure of a normed vector space, an algebra and a lattice. On the one hand we study the relations between these structures and the topology of X, on the other hand we discuss a number of classical results according to which an algebra or a vector lattice can be represented as a C(X). Various applications of these theorems are given. Some attention is devoted to related theorems, e.g. the Stone Theorem for Boolean algebras and the Riesz Representation Theorem. The book is functional analytic in character. It does not presuppose much knowledge of functional analysis; it contains introductions into subjects such as the weak topology, vector lattices and (some) integration theory.

  12. Quantal density functional theory

    CERN Document Server

    Sahni, Viraht

    2016-01-01

    This book deals with quantal density functional theory (QDFT) which is a time-dependent local effective potential theory of the electronic structure of matter. The treated time-independent QDFT constitutes a special case. In the 2nd edition, the theory is extended to include the presence of external magnetostatic fields. The theory is a description of matter based on the ‘quantal Newtonian’ first and second laws which is in terms of “classical” fields that pervade all space, and their quantal sources. The fields, which are explicitly defined, are separately representative of electron correlations due to the Pauli exclusion principle, Coulomb repulsion, correlation-kinetic, correlation-current-density, and correlation-magnetic effects. The book further describes Schrödinger theory from the new physical perspective of fields and quantal sources. It also describes traditional Hohenberg-Kohn-Sham DFT, and explains via QDFT the physics underlying the various energy functionals and functional derivatives o...

  13. Platelet function in dogs

    DEFF Research Database (Denmark)

    Nielsen, Line A.; Zois, Nora Elisabeth; Pedersen, Henrik D.

    2007-01-01

    Background: Clinical studies investigating platelet function in dogs have had conflicting results that may be caused by normal physiologic variation in platelet response to agonists. Objectives: The objective of this study was to investigate platelet function in clinically healthy dogs of 4...... different breeds by whole-blood aggregometry and with a point-of-care platelet function analyzer (PFA-100), and to evaluate the effect of acetylsalicylic acid (ASA) administration on the results from both methods. Methods: Forty-five clinically healthy dogs (12 Cavalier King Charles Spaniels [CKCS], 12...... applied. However, the importance of these breed differences remains to be investigated. The PFA-100 method with Col + Epi as agonists, and ADP-induced platelet aggregation appear to be sensitive to ASA in dogs....

  14. The triad value function

    DEFF Research Database (Denmark)

    Vedel, Mette

    2016-01-01

    the triad value function. Next, the applicability and validity of the concept is examined in a case study of four closed vertical supply chain triads. Findings - The case study demonstrates that the triad value function facilitates the analysis and understanding of an apparent paradox; that distributors...... expands exponentially with the number of ties in the network. Moreover, it must be applied in the study of service triads and open vertical supply chain triads to further verify the practical adequacy of the concept. Practical implications - The triad value function cannot be used normatively...... or prescriptively. It is a descriptive tool which indirectly supports managerial decision-making through the analysis of how the structural context of a triad influences the value of relationships. Originality/value - The paper offers an additional aspect for the study of value in and of triads. It illustrates...

  15. Functional Programming Using F#

    DEFF Research Database (Denmark)

    Hansen, Michael Reichhardt; Rischel, Hans

    This comprehensive introduction to the principles of functional programming using F# shows how to apply basic theoretical concepts to produce succinct and elegant programs. It demonstrates the role of functional programming in a wide spectrum of applications including databases and systems....... Coverage also includes advanced features in the .NET library, the imperative features of F# and topics such as text processing, sequences, computation expressions and asynchronous computation. With a broad spectrum of examples and exercises, the book is perfect for courses in functional programming...... and for self-study. Enhancing its use as a text is an accompanying website with downloadable programs, lecture slides, a mini-projects and links to further F# sources....

  16. Functional brain imaging

    International Nuclear Information System (INIS)

    Frackowiak, R.S.J.

    1996-01-01

    Major advances in computing and mathematics, especially the back-projection algorithms introduced for reconstructing tomographic data obtained by non-invasive imaging, have led to new opportunities for the study of the structure, function and structure-function relationships of the human brain. Functional neuro-imaging methods fall, broadly, into two classes. Those methods that provide information about synaptic activity and those that provide information of a chemical or neurochemical nature. The former methods usually depend on some form of perfusion mapping because of the tight coupling between local glucose metabolism and blood flow in the brain at rest and at times of altered synaptic activity. The latter methods depend on identification of a chemical species of interest by using an appropriate radioligand, or by using the intrinsic magnetic properties of a compound. (author)

  17. Functional illiteracy in Slovenia

    Directory of Open Access Journals (Sweden)

    Ester Možina

    1999-12-01

    Full Text Available The author draws attention to the fact that, in determining functional illiteracy, there remain many terminological disagreements and diverse opinions regarding illiteracy. Furthermore, there are also different methods for measuring writing abilities, thus leading to disparate results. The introductory section presents the dilemmas relating to the term of functional illiteracy, while the second part is concerned with the various methods for measuring literacy. Thus, the author also critically assesses the research studies aimed at evaluating the scope of literacy amongst adults in Slovenia during the past decade. ln this paper, she has adopted a methodology which would not determine what is functional and what is not in our society, in order to avoid limiting the richness of individual writing praxis.

  18. Nucleon structure functions

    International Nuclear Information System (INIS)

    Virchaux, M.

    1992-11-01

    The present status of experimental measurements of the nucleon structure functions is reviewed. The results from nearly all deep inelastic experiments are in good mutual agreement. Principles of the analysis of these structure function data in the framework of QCD are described. The specific features of the perturbative QCD predictions are observed in the data. This provides quantitative tests of the validity of QCD as well as determinations of the various parton distributions in the nucleon and some of the most precise measurements of the strong coupling constant αs. The future of this field of experimental physics is sketched

  19. The Functions of Sleep

    OpenAIRE

    Samson Z Assefa; Montserrat Diaz-Abad; Emerson M Wickwire; Steven M Scharf

    2015-01-01

    Sleep is a ubiquitous component of animal life including birds and mammals. The exact function of sleep has been one of the mysteries of biology. A considerable number of theories have been put forward to explain the reason(s) for the necessity of sleep. To date, while a great deal is known about what happens when animals sleep, there is no definitive comprehensive explanation as to the reason that sleep is an inevitable part of animal functioning. It is well known that sleep is a homeostatic...

  20. Ego functions in epilepsy

    DEFF Research Database (Denmark)

    Sørensen, A S; Hansen, H; Høgenhaven, H

    1988-01-01

    Two groups of epilepsy patients (28 patients with temporal lobe epilepsy and 15 patients with primary generalized epilepsy) entered a study of personality traits related to epilepsy, based on a modification of Bellak's semistructured interview for assessment of ego strength. Two groups of subjects...... than 15 years when the disease began. The number of anticonvulsants administered did not influence the results. No difference on adaptive level of ego functioning was found between the group with primary generalized epilepsy and the group with temporal lobe epilepsy. Similarly, the temporal lobe...... epilepsy group with predominantly right-sided and left-sided EEG changes, respectively, showed similar adaptive levels of ego functioning....

  1. Complex function theory

    CERN Document Server

    Sarason, Donald

    2007-01-01

    Complex Function Theory is a concise and rigorous introduction to the theory of functions of a complex variable. Written in a classical style, it is in the spirit of the books by Ahlfors and by Saks and Zygmund. Being designed for a one-semester course, it is much shorter than many of the standard texts. Sarason covers the basic material through Cauchy's theorem and applications, plus the Riemann mapping theorem. It is suitable for either an introductory graduate course or an undergraduate course for students with adequate preparation. The first edition was published with the title Notes on Co

  2. GADRAS Detector Response Function.

    Energy Technology Data Exchange (ETDEWEB)

    Mitchell, Dean J.; Harding, Lee; Thoreson, Gregory G; Horne, Steven M.

    2014-11-01

    The Gamma Detector Response and Analysis Software (GADRAS) applies a Detector Response Function (DRF) to compute the output of gamma-ray and neutron detectors when they are exposed to radiation sources. The DRF is fundamental to the ability to perform forward calculations (i.e., computation of the response of a detector to a known source), as well as the ability to analyze spectra to deduce the types and quantities of radioactive material to which the detectors are exposed. This document describes how gamma-ray spectra are computed and the significance of response function parameters that define characteristics of particular detectors.

  3. Chromatin Structure and Function

    CERN Document Server

    Wolffe, Alan P

    1999-01-01

    The Third Edition of Chromatin: Structure and Function brings the reader up-to-date with the remarkable progress in chromatin research over the past three years. It has been extensively rewritten to cover new material on chromatin remodeling, histone modification, nuclear compartmentalization, DNA methylation, and transcriptional co-activators and co-repressors. The book is written in a clear and concise fashion, with 60 new illustrations. Chromatin: Structure and Function provides the reader with a concise and coherent account of the nature, structure, and assembly of chromatin and its active

  4. Integral inequalities under beta function and preinvex type functions.

    Science.gov (United States)

    Ahmad, Izhar

    2016-01-01

    In the present paper, the notion of P-preinvex function is introduced and new integral inequalities for this kind of function along with beta function are establised. The work extends the results appeared in the literature.

  5. Graphical functions in parametric space

    Science.gov (United States)

    Golz, Marcel; Panzer, Erik; Schnetz, Oliver

    2017-06-01

    Graphical functions are positive functions on the punctured complex plane C{\\setminus }{0,1} which arise in quantum field theory. We generalize a parametric integral representation for graphical functions due to Lam, Lebrun and Nakanishi, which implies the real analyticity of graphical functions. Moreover, we prove a formula that relates graphical functions of planar dual graphs.

  6. Diet and Endothelial Function

    Directory of Open Access Journals (Sweden)

    ADA M CUEVAS

    2004-01-01

    Full Text Available Endothelial dysfunction is one of the earliest events in atherogenesis. A consequence of endothelial damage is a lower availability of nitric oxide (NO, the most potent endogenous vasodilator. NO inhibits platelet aggregation, smooth muscle cell proliferation and adhesion of monocytes to endothelial cells. Endothelial dysfunction is present in patients with cardiovascular disease and/or coronary risk factors, such as hypertension, dyslipidemia, diabetes, smoking or hyperhomocysteinemia. At present, soluble markers and high resolution ultrasound of the brachial artery, have provided simple tools for the study of endothelial function and the effects of several interventions. It has been demonstrated that dietary factors may induce significant changes on vascular reactivity. Nutrients, such as fish oil, antioxidants, L-arginine, folic acid and soy protein have shown an improvement in endothelial function that can mediate, at least partially, the cardioprotective effects of these substances. Attention has been focused on dietary patterns in populations with lower prevalence of cardiovascular disease. There is some evidence suggesting that Mediterranean diet characterized by high consumption of vegetables, fish, olive oil and moderate wine consumption may have a positive effect on endothelial function. These results give us evidence on the significant role of diet on endothelial function and its impact on the pathogenesis of atherosclerosis

  7. Automatic Functional Harmonic Analysis

    NARCIS (Netherlands)

    de Haas, W.B.|info:eu-repo/dai/nl/304841250; Magalhães, J.P.; Wiering, F.|info:eu-repo/dai/nl/141928034; Veltkamp, R.C.|info:eu-repo/dai/nl/084742984

    2013-01-01

    Music scholars have been studying tonal harmony intensively for centuries, yielding numerous theories and models. Unfortunately, a large number of these theories are formulated in a rather informal fashion and lack mathematical precision. In this article we present HarmTrace, a functional model of

  8. Functions of public relations

    Directory of Open Access Journals (Sweden)

    Baranov G. V.

    2016-09-01

    Full Text Available the article reveals the importance of communication with the public in the implementation of human rights and the ideals of mankind; characterized by the specificity of public relations in the information culture of belief; PR functions are explained on the criterion of optimization of activity of social interactions on the basis of cultural ideals.

  9. Linear Classification Functions.

    Science.gov (United States)

    Huberty, Carl J.; Smith, Jerry D.

    Linear classification functions (LCFs) arise in a predictive discriminant analysis for the purpose of classifying experimental units into criterion groups. The relative contribution of the response variables to classification accuracy may be based on LCF-variable correlations for each group. It is proved that, if the raw response measures are…

  10. Fuss Over Function

    DEFF Research Database (Denmark)

    Elsmore, Matthew James

    is an inherent work-in-progress, and hence labelled ‘Draft’. Moreover, this precise point, and my intended wider audience, also helps explain the inclusion of this essay on SSRN. Note: This draft essay has not been reviewed. Thus, any comments on its form and function are welcome, either via the IPKat post...

  11. Executive functions in synesthesia

    NARCIS (Netherlands)

    Rouw, R.; van Driel, J.; Knip, K.; Ridderinkhof, K.R.

    2013-01-01

    In grapheme-color synesthesia, a number or letter can evoke two different and possibly conflicting (real and synesthetic) color sensations at the same time. In this study, we investigate the relationship between synesthesia and executive control functions. First, no general skill differences were

  12. Functional ingredients from microalgae

    NARCIS (Netherlands)

    Buono, S.; Langellotti, A.L.; Martello, A.; Rinna, F.; Fogliano, V.

    2014-01-01

    A wide variety of natural sources are under investigation to evaluate their possible use for new functional ingredient formulation. Some records attested the traditional and ancient use of wild harvested microalgae as human food but their cultivation for different purposes started about 40 years

  13. Gluing Nekrasov Partition Functions

    Science.gov (United States)

    Qiu, Jian; Tizzano, Luigi; Winding, Jacob; Zabzine, Maxim

    2015-07-01

    In this paper we summarise the localisation calculation of 5D super Yang-Mills on simply connected toric Sasaki-Einstein (SE) manifolds. We show how various aspects of the computation, including the equivariant index, the asymptotic behaviour and the factorisation property are governed by the combinatorial data of the toric geometry. We prove that the perturbative partition function on a simply connected SE manifold corresponding to an n-gon toric diagram factorises to n copies of perturbative part (zero instanton sector) of the Nekrasov partition function. This leads us to conjecture a prescription for the computation of the complete partition function, by gluing n copies of the full Nekrasov partition functions. This work is a generalisation of some earlier computation carried out on Y p, q manifolds, whose moment map cone has a quadrangle base and our result is valid for manifolds whose moment map cones have pentagon base, hexagon base, etc. The algorithm we used for dealing with general cones may also be of independent interest.

  14. Objectification and Semiotic Function

    Science.gov (United States)

    Santi, George

    2011-01-01

    The objective of this paper is to study students' difficulties when they have to ascribe the same meaning to different representations of the same mathematical object. We address two theoretical tools that are at the core of Radford's cultural semiotic and Godino's onto-semiotic approaches: objectification and the semiotic function. The analysis…

  15. The Grindahl Hash Functions

    DEFF Research Database (Denmark)

    Knudsen, Lars Ramkilde; Rechberger, Christian; Thomsen, Søren Steffen

    2007-01-01

    In this paper we propose the Grindahl hash functions, which are based on components of the Rijndael algorithm. To make collision search sufficiently difficult, this design has the important feature that no low-weight characteristics form collisions, and at the same time it limits access to the st...

  16. Functional System Dynamics

    NARCIS (Netherlands)

    Ligterink, N.E.

    2007-01-01

    Functional system dynamics is the analysis, modelling, and simulation of continuous systems usually described by partial differential equations. From the infinite degrees of freedom of such systems only a finite number of relevant variables have to be chosen for a practical model description. The

  17. Nonlinear functional analysis

    CERN Document Server

    Deimling, Klaus

    1985-01-01

    topics. However, only a modest preliminary knowledge is needed. In the first chapter, where we introduce an important topological concept, the so-called topological degree for continuous maps from subsets ofRn into Rn, you need not know anything about functional analysis. Starting with Chapter 2, where infinite dimensions first appear, one should be familiar with the essential step of consider­ ing a sequence or a function of some sort as a point in the corresponding vector space of all such sequences or functions, whenever this abstraction is worthwhile. One should also work out the things which are proved in § 7 and accept certain basic principles of linear functional analysis quoted there for easier references, until they are applied in later chapters. In other words, even the 'completely linear' sections which we have included for your convenience serve only as a vehicle for progress in nonlinearity. Another point that makes the text introductory is the use of an essentially uniform mathematical languag...

  18. Functional Communication Training

    Science.gov (United States)

    Durand, V. Mark; Moskowitz, Lauren

    2015-01-01

    Thirty years ago, the first experimental demonstration was published showing that educators could improve significant challenging behavior in children with disabilities by replacing these behaviors with forms of communication that served the same purpose, a procedure called functional communication training (FCT). Since the publication of that…

  19. The function of ornaments

    DEFF Research Database (Denmark)

    Glaveanu, Vlad Petre

    2014-01-01

    of their manifold functions that integrates aesthetic and utilitarian, individual and social roles. Ornaments help us to identify and locate, tell or communicate, remind and organise our action, they guide our attention, express and individualise, can generate an experience, beautify as well as re...

  20. Automate functional testing

    Directory of Open Access Journals (Sweden)

    Ramesh Kalindri

    2014-06-01

    Full Text Available Currently, software engineers are increasingly turning to the option of automating functional tests, but not always have successful in this endeavor. Reasons range from low planning until over cost in the process. Some principles that can guide teams in automating these tests are described in this article.

  1. Density Functional Theory

    Indian Academy of Sciences (India)

    (1) The total energy of an electron system in an external potential is a unique functional of the total electron density; and. (2)The density that minimizes the energy is the ground-state density, and this minimum energy is the ground-state energy of the system.

  2. Functional consequences of hemispherectomy

    NARCIS (Netherlands)

    van Empelen, R; Jennekens-Schinkel, A; Buskens, E; Helders, PJM; van Nieuwenhuizen, O

    Using the International Classification of Functioning Disability and Health (ICF) (WHO, 2001), impairments, activities and social participation are reported in 12 children (mean age at surgery 5.9 years) who were investigated before and three times over a 2-year period after hemispherectomy.

  3. Laboratory Density Functionals

    OpenAIRE

    Giraud, B. G.

    2007-01-01

    We compare several definitions of the density of a self-bound system, such as a nucleus, in relation with its center-of-mass zero-point motion. A trivial deconvolution relates the internal density to the density defined in the laboratory frame. This result is useful for the practical definition of density functionals.

  4. Choice probability generating functions

    DEFF Research Database (Denmark)

    Fosgerau, Mogens; McFadden, Daniel; Bierlaire, Michel

    2013-01-01

    This paper considers discrete choice, with choice probabilities coming from maximization of preferences from a random utility field perturbed by additive location shifters (ARUM). Any ARUM can be characterized by a choice-probability generating function (CPGF) whose gradient gives the choice...

  5. Choice Probability Generating Functions

    DEFF Research Database (Denmark)

    Fosgerau, Mogens; McFadden, Daniel L; Bierlaire, Michel

    This paper considers discrete choice, with choice probabilities coming from maximization of preferences from a random utility field perturbed by additive location shifters (ARUM). Any ARUM can be characterized by a choice-probability generating function (CPGF) whose gradient gives the choice...

  6. Mapping functional connectivity

    Science.gov (United States)

    Peter Vogt; Joseph R. Ferrari; Todd R. Lookingbill; Robert H. Gardner; Kurt H. Riitters; Katarzyna Ostapowicz

    2009-01-01

    An objective and reliable assessment of wildlife movement is important in theoretical and applied ecology. The identification and mapping of landscape elements that may enhance functional connectivity is usually a subjective process based on visual interpretations of species movement patterns. New methods based on mathematical morphology provide a generic, flexible,...

  7. Empirical microeconomics action functionals

    Science.gov (United States)

    Baaquie, Belal E.; Du, Xin; Tanputraman, Winson

    2015-06-01

    A statistical generalization of microeconomics has been made in Baaquie (2013), where the market price of every traded commodity, at each instant of time, is considered to be an independent random variable. The dynamics of commodity market prices is modeled by an action functional-and the focus of this paper is to empirically determine the action functionals for different commodities. The correlation functions of the model are defined using a Feynman path integral. The model is calibrated using the unequal time correlation of the market commodity prices as well as their cubic and quartic moments using a perturbation expansion. The consistency of the perturbation expansion is verified by a numerical evaluation of the path integral. Nine commodities drawn from the energy, metal and grain sectors are studied and their market behavior is described by the model to an accuracy of over 90% using only six parameters. The paper empirically establishes the existence of the action functional for commodity prices that was postulated to exist in Baaquie (2013).

  8. Functional genomics of tomato

    Indian Academy of Sciences (India)

    2014-10-20

    Oct 20, 2014 ... very first challenge before scientists working on tomato functional biology is to exploit this high-quality reference sequence for tapping of the ... and exploitation of the genomic diversity present in Solanum genus, in general, and ..... associated with this tool retain its labour-intensive nature, ineffectiveness for ...

  9. Generalized elementary functions

    Czech Academy of Sciences Publication Activity Database

    Monteiro, Giselle Antunes; Slavík, A.

    2014-01-01

    Roč. 411, č. 2 (2014), s. 838-852 ISSN 0022-247X Institutional support: RVO:67985840 Keywords : elementary functions * Kurzweil-Stieltjes integral * generalized linear ordinary differential equations * time scale calculus Subject RIV: BA - General Mathematics Impact factor: 1.120, year: 2014 http://www.sciencedirect.com/science/article/pii/S0022247X13009141

  10. Functional Maximum Autocorrelation Factors

    DEFF Research Database (Denmark)

    Larsen, Rasmus; Nielsen, Allan Aasbjerg

    2005-01-01

    \\verb+~+\\$\\backslash\\$cite{ramsay97} to functional maximum autocorrelation factors (MAF)\\verb+~+\\$\\backslash\\$cite{switzer85,larsen2001d}. We apply the method to biological shapes as well as reflectance spectra. {\\$\\backslash\\$bf Methods}. MAF seeks linear combination of the original variables that maximize autocorrelation between...

  11. Cobham recursive set functions

    Czech Academy of Sciences Publication Activity Database

    Beckmann, A.; Buss, S.; Friedman, S.-D.; Müller, M.; Thapen, Neil

    2016-01-01

    Roč. 167, č. 3 (2016), s. 335-369 ISSN 0168-0072 R&D Projects: GA ČR GBP202/12/G061 Institutional support: RVO:67985840 Keywords : set function * polynomial time * Cobham recursion Subject RIV: BA - General Mathematics Impact factor: 0.647, year: 2016 http://www.sciencedirect.com/science/article/pii/S0168007215001293

  12. density functional theory (DFT)

    Indian Academy of Sciences (India)

    Abstract. In the present investigation, interaction of ruthenium (Ru) atoms with fluorine (F) atoms was studied using the density functional theory utilizing B3LYP method. It was found that up to seven F atoms can bind to a single Ru atom which results in increase of electron affinities successively, reaching a peak value of ...

  13. Educating executive function.

    Science.gov (United States)

    Blair, Clancy

    2017-01-01

    Executive functions are thinking skills that assist with reasoning, planning, problem solving, and managing one's life. The brain areas that underlie these skills are interconnected with and influenced by activity in many different brain areas, some of which are associated with emotion and stress. One consequence of the stress-specific connections is that executive functions, which help us to organize our thinking, tend to be disrupted when stimulation is too high and we are stressed out, or too low when we are bored and lethargic. Given their central role in reasoning and also in managing stress and emotion, scientists have conducted studies, primarily with adults, to determine whether executive functions can be improved by training. By and large, results have shown that they can be, in part through computer-based videogame-like activities. Evidence of wider, more general benefits from such computer-based training, however, is mixed. Accordingly, scientists have reasoned that training will have wider benefits if it is implemented early, with very young children as the neural circuitry of executive functions is developing, and that it will be most effective if embedded in children's everyday activities. Evidence produced by this research, however, is also mixed. In sum, much remains to be learned about executive function training. Without question, however, continued research on this important topic will yield valuable information about cognitive development. WIREs Cogn Sci 2017, 8:e1403. doi: 10.1002/wcs.1403 For further resources related to this article, please visit the WIREs website. © 2016 Wiley Periodicals, Inc.

  14. Uniqueness property for quasiharmonic functions

    Directory of Open Access Journals (Sweden)

    Sevdiyor A. Imomkulov

    2014-10-01

    Full Text Available In this paper we consider a class of continuous functions, called quasiaharmonic functions, admitting best approximations by harmonic polynomials. In this class we prove a uniqueness theorem by analogy with the analytic functions.

  15. Quasi-extended asymptotic functions

    International Nuclear Information System (INIS)

    Todorov, T.D.

    1979-01-01

    The class F of ''quasi-extended asymptotic functions'' is introduced. It contains all extended asymptotic functions as well as some new asymptotic functions very similar to the Schwartz distributions. On the other hand, every two quasiextended asymptotic functions can be multiplied as opposed to the Schwartz distributions; in particular, the square delta 2 of an asymptotic function delta similar to Dirac's delta-function, is constructed as an example

  16. The Relationships between Weight Functions, Geometric Functions,and Compliance Functions in Linear Elastic Fracture Mechanics

    Energy Technology Data Exchange (ETDEWEB)

    Yuan, Rong [Univ. of California, Berkeley, CA (United States)

    2007-01-01

    Linear elastic fracture mechanics is widely used in industry because it established simple and explicit relationships between the permissible loading conditions and the critical crack size that is allowed in a structure. Stress intensity factors are the above-mentioned functional expressions that relate load with crack size through geometric functions or weight functions. Compliance functions are to determine the crack/flaw size in a structure when optical inspection is inconvenient. As a result, geometric functions, weight functions and compliance functions have been intensively studied to determine the stress intensity factor expressions for different geometries. However, the relations between these functions have received less attention. This work is therefore to investigate the intrinsic relationships between these functions. Theoretical derivation was carried out and the results were verified on single-edge cracked plate under tension and bending. It is found out that the geometric function is essentially the non-dimensional weight function at the loading point. The compliance function is composed of two parts: a varying part due to crack extension and a constant part from the intact structure if no crack exists. The derivative of the compliance function at any location is the product of the geometric function and the weight function at the evaluation point. Inversely, the compliance function can be acquired by the integration of the product of the geometric function and the weight function with respect to the crack size. The integral constant is just the unchanging compliance from the intact structure. Consequently, a special application of the relations is to obtain the compliance functions along a crack once the geometric function and weight functions are known. Any of the three special functions can be derived once the other two functions are known. These relations may greatly simplify the numerical process in obtaining either geometric functions, weight

  17. Density functional theory

    International Nuclear Information System (INIS)

    Das, M.P.

    1984-07-01

    The state of the art of the density functional formalism (DFT) is reviewed. The theory is quantum statistical in nature; its simplest version is the well-known Thomas-Fermi theory. The DFT is a powerful formalism in which one can treat the effect of interactions in inhomogeneous systems. After some introductory material, the DFT is outlined from the two basic theorems, and various generalizations of the theorems appropriate to several physical situations are pointed out. Next, various approximations to the density functionals are presented and some practical schemes, discussed; the approximations include an electron gas of almost constant density and an electron gas of slowly varying density. Then applications of DFT in various diverse areas of physics (atomic systems, plasmas, liquids, nuclear matter) are mentioned, and its strengths and weaknesses are pointed out. In conclusion, more recent developments of DFT are indicated

  18. Differentiation of real functions

    CERN Document Server

    Bruckner, Andrew

    1994-01-01

    Topics related to the differentiation of real functions have received considerable attention during the last few decades. This book provides an efficient account of the present state of the subject. Bruckner addresses in detail the problems that arise when dealing with the class \\Delta ' of derivatives, a class that is difficult to handle for a number of reasons. Several generalized forms of differentiation have assumed importance in the solution of various problems. Some generalized derivatives are excellent substitutes for the ordinary derivative when the latter is not known to exist; others are not. Bruckner studies generalized derivatives and indicates "geometric" conditions that determine whether or not a generalized derivative will be a good substitute for the ordinary derivative. There are a number of classes of functions closely linked to differentiation theory, and these are examined in some detail. The book unifies many important results from the literature as well as some results not previously pub...

  19. Process for functionalizing alkanes

    Science.gov (United States)

    Bergman, R.G.; Janowicz, A.H.; Periana-Pillai, R.A.

    1984-06-12

    Process for functionalizing saturated hydrocarbons selectively in the terminal position comprises: (a) reacting said saturated hydrocarbons with a metal complex CpRhPMe/sub 3/H/sub 2/ in the presence of ultraviolet radiation at -60/sup 0/ to -17/sup 0/C to form a hydridoalkyl complex CpRhPMe/sub 3/RH; (b) reacting said hydridoalkyl complex with a haloform CHX/sub 3/ at -60/sup 0/ to -17/sup 0/C to form the corresponding haloalkyl complex of step (a) CpRhPMe/sub 3/RX; and (c) reacting said haloalkyl complex with halogen -60 to 25/sup 0/C to form a functional haloalkyl compound.

  20. Nuclear Parton Distribution Functions

    Energy Technology Data Exchange (ETDEWEB)

    I. Schienbein, J.Y. Yu, C. Keppel, J.G. Morfin, F. Olness, J.F. Owens

    2009-06-01

    We study nuclear effects of charged current deep inelastic neutrino-iron scattering in the framework of a {chi}{sup 2} analysis of parton distribution functions (PDFs). We extract a set of iron PDFs which are used to compute x{sub Bj}-dependent and Q{sup 2}-dependent nuclear correction factors for iron structure functions which are required in global analyses of free nucleon PDFs. We compare our results with nuclear correction factors from neutrino-nucleus scattering models and correction factors for charged-lepton--iron scattering. We find that, except for very high x{sub Bj}, our correction factors differ in both shape and magnitude from the correction factors of the models and charged-lepton scattering.

  1. Ramanujan's theta functions

    CERN Document Server

    Cooper, Shaun

    2017-01-01

    Theta functions were studied extensively by Ramanujan. This book provides a systematic development of Ramanujan’s results and extends them to a general theory. The author’s treatment of the subject is comprehensive, providing a detailed study of theta functions and modular forms for levels up to 12. Aimed at advanced undergraduates, graduate students, and researchers, the organization, user-friendly presentation, and rich source of examples, lends this book to serve as a useful reference, a pedagogical tool, and a stimulus for further research. Topics, especially those discussed in the second half of the book, have been the subject of much recent research; many of which are appearing in book form for the first time. Further results are summarized in the numerous exercises at the end of each chapter.

  2. Functional foods in Europe

    DEFF Research Database (Denmark)

    Bech-Larsen, Tino; Scholderer, Joachim

    2007-01-01

    reading of the main principles of the harmonized regulation COM/2003/0424, this situation is about to change. This article reviews the regulatory aspects, the results of consumer research and the marketing strategies regarding the use of health claims for functional foods in Europe, and it comments......The fact that the European markets for functional foods generally are less developed, compared to the US and the Japanese markets, has often been attributed to a restrictive and inconsistent health claim legislation in and between the European countries. With the European Parliament's second...... on the lack of correspondence between the new regulation and the marketing experiences and research as regard consumer reactions to health claims....

  3. Functionalization of Carbon Nanotubes

    Science.gov (United States)

    Khare, Bishun N. (Inventor); Meyyappan, Meyya (Inventor)

    2009-01-01

    Method and system for functionalizing a collection of carbon nanotubes (CNTs). A selected precursor gas (e.g., H2 or F2 or CnHm) is irradiated to provide a cold plasma of selected target species particles, such as atomic H or F, in a first chamber. The target species particles are d irected toward an array of CNTs located in a second chamber while suppressing transport of ultraviolet radiation to the second chamber. A CNT array is functionalized with the target species particles, at or below room temperature, to a point of saturation, in an exposure time interval no longer than about 30 sec. *Discrimination against non-target species is provided by (i) use of a target species having a lifetime that is much greater than a lifetime of a non-target species and/or (2) use of an applied magnetic field to discriminate between charged particle trajectories for target species and for non-target species.

  4. Functional studies using NMR

    International Nuclear Information System (INIS)

    McCready, V.R.; Leach, M.; Ell, P.J.

    1987-01-01

    This volume is based on a series of lectures delivered at a one-day teaching symposium on functional and metabolic aspects of NMR measurements held at the Middlesex Hospital Medical School on 1st September 1985 as a part of the European Nuclear Medicine Society Congress. Currently the major emphasis in medical NMR in vivo is on its potential to image and display abnormalities in conventional radiological images, providing increased contrast between normal and abnormal tissue, improved definition of vasculature, and possibly an increased potential for differential diagnosis. Although these areas are undeniably of major importance, it is probable that NMR will continue to complement conventional measurement methods. The major potential benefits to be derived from in vivo NMR measurements are likely to arise from its use as an instrument for functional and metabolic studies in both clinical research and in the everyday management of patients. It is to this area that this volume is directed

  5. Sexual function and obesity

    DEFF Research Database (Denmark)

    Larsen, S H; Wagner, G; Heitmann, B L

    2007-01-01

    function and dysfunction. COMMENTS: Four prospective and seven cross-sectional studies were found describing association between obesity and erectile dysfunction (ED). One cross-sectional study was found describing obesity and female sexual dysfunction (FSD). The prospective studies on ED all demonstrated......OBJECTIVE: To review the literature on the relationship between obesity and sexual function. METHOD: A search in the medical literature from 1966 and onwards was carried out through Medline and Embase for publications on obesity, in combination with Medical Subject Heading words related to sexual...... a direct association and so did five of the seven cross-sectional studies. The single FSD study did not find any relationship. Eight intervention studies on weight loss and sexual difficulties were identified. All included few individuals and results were mixed even if most indicated an increase of sexual...

  6. Ego functions in epilepsy

    DEFF Research Database (Denmark)

    Sørensen, A S; Hansen, H; Høgenhaven, H

    1988-01-01

    Two groups of epilepsy patients (28 patients with temporal lobe epilepsy and 15 patients with primary generalized epilepsy) entered a study of personality traits related to epilepsy, based on a modification of Bellak's semistructured interview for assessment of ego strength. Two groups of subjects...... served as controls: 15 patients with a non-neurological but relapsing disorder, psoriasis, and 15 healthy volunteers. Compared with the group of healthy volunteers, a decreased adaptive level of ego functioning was found in the epilepsy groups, regardless of seizure types and EEG findings, and...... than 15 years when the disease began. The number of anticonvulsants administered did not influence the results. No difference on adaptive level of ego functioning was found between the group with primary generalized epilepsy and the group with temporal lobe epilepsy. Similarly, the temporal lobe...

  7. The Function of Sleep

    Directory of Open Access Journals (Sweden)

    Daniel A. Barone

    2015-06-01

    Full Text Available The importance of sleep can be ascertained by noting the effects of its loss, which tends to be chronic and partial, on cognition, mood, alertness, and overall health. Many theories have been put forth to explain the function of sleep in humans, including proposals based on energy conservation, ecological adaptations, neurocognitive function, neural plasticity, nervous system and physical health, and performance. Most account for only a portion of sleep behavior and few are based on strong experimental support. In this review, we present theories proposing why sleep is necessary and supporting data demonstrating the effects of inadequate sleep, with the intention of gleaning further information as to its necessity, which remains one of the most perplexing mysteries in biology.

  8. Pancreatic exocrine function testing

    International Nuclear Information System (INIS)

    Goff, J.S.

    1981-01-01

    It is important to understand which pancreatic function tests are available and how to interpret them when evaluating patients with malabsorption. Available direct tests are the secretin stimulation test, the Lundh test meal, and measurement of serum or fecal enzymes. Indirect tests assess pancreatic exocrine function by measuring the effect of pancreatic secretion on various nutrients. These include triglycerides labeled with carbon 14, cobalamin labeled with cobalt 57 and cobalt 58, and para-aminobenzoic acid bound to a dipeptide. Of all these tests the secretin stimulation test is the most accurate and reliable if done by experienced personnel. However, the indirect tests are simpler to do and appear to be comparable to the secretin test at detecting pancreatic exocrine insufficiency. These indirect tests are becoming clinically available and clinicians should familiarize themselves with the strengths and weaknesses of each

  9. Towards the Innovation Function

    Directory of Open Access Journals (Sweden)

    Paulo Antônio Zawislak

    2008-12-01

    Full Text Available This paper explores the main elements that influence innovation and the relationships among them. It is pointed out that innovation results from an entrepreneurial action inside an established institutional context, sustained by resources, abilities and competences and with the support of the necessary financial capital. Therefore, it is proposed that innovation is a function (just as the microeconomic production function composed of entrepreneurship, institutions, capabilities and capital. Each one of these elements is explored individually, so that later the relationships among them can be analyzed. It is still suggested that the size of the firm is a moderator in the relationship between these elements and innovation. The study’s contribution it is the development of a conceptual model.

  10. Vestibular function testing.

    LENUS (Irish Health Repository)

    Lang, E E

    2010-06-01

    Vestibular symptoms of vertigo, dizziness and dysequilibrium are common complaints which can be disabling both physically and psychologically. Routine examination of the ear nose and throat and neurological system are often normal in these patients. An accurate history and thorough clinical examination can provide a diagnosis in the majority of patients. However, in a subgroup of patients, vestibular function testing may be invaluable in arriving at a correct diagnosis and ultimately in the optimal treatment of these patients.

  11. Applied functional analysis

    CERN Document Server

    Oden, J Tinsley

    2010-01-01

    The textbook is designed to drive a crash course for beginning graduate students majoring in something besides mathematics, introducing mathematical foundations that lead to classical results in functional analysis. More specifically, Oden and Demkowicz want to prepare students to learn the variational theory of partial differential equations, distributions, and Sobolev spaces and numerical analysis with an emphasis on finite element methods. The 1996 first edition has been used in a rather intensive two-semester course. -Book News, June 2010

  12. Generalised twisted partition functions

    CERN Document Server

    Petkova, V B

    2001-01-01

    We consider the set of partition functions that result from the insertion of twist operators compatible with conformal invariance in a given 2D Conformal Field Theory (CFT). A consistency equation, which gives a classification of twists, is written and solved in particular cases. This generalises old results on twisted torus boundary conditions, gives a physical interpretation of Ocneanu's algebraic construction, and might offer a new route to the study of properties of CFT.

  13. Cobham recursive set functions

    Czech Academy of Sciences Publication Activity Database

    Beckmann, A.; Buss, S.; Friedman, S.-D.; Müller, M.; Thapen, Neil

    2016-01-01

    Roč. 167, č. 3 (2016), s. 335-369 ISSN 0168-0072 R&D Projects: GA ČR GBP202/12/G061 Institutional support: RVO:67985840 Keywords : set function * polynomial time * Cobham recursion Subject RIV: BA - General Mathematics Impact factor: 0.647, year: 2016 http://www. science direct.com/ science /article/pii/S0168007215001293

  14. Function integrated track system

    OpenAIRE

    Hohnecker, Eberhard

    2010-01-01

    The paper discusses a function integrated track system that focuses on the reduction of acoustic emissions from railway lines. It is shown that the combination of an embedded rail system (ERS), a sound absorbing track surface, and an integrated mini sound barrier has significant acoustic advantages compared to a standard ballast superstructure. The acoustic advantages of an embedded rail system are particularly pronounced in the case of railway bridges. Finally, it is shown that a...

  15. Controlling Lipschitz functions

    OpenAIRE

    Kupavskii, Andrey; Pach, Janos; Tardos, Gabor

    2017-01-01

    Given any positive integers $m$ and $d$, we say the a sequence of points $(x_i)_{i\\in I}$ in $\\mathbb R^m$ is {\\em Lipschitz-$d$-controlling} if one can select suitable values $y_i\\; (i\\in I)$ such that for every Lipschitz function $f:\\mathbb R^m\\rightarrow \\mathbb R^d$ there exists $i$ with $|f(x_i)-y_i|

  16. Migrativity of aggregation functions

    Czech Academy of Sciences Publication Activity Database

    Bustince, H.; Montero, J.; Mesiar, Radko

    2009-01-01

    Roč. 160, č. 6 (2009), s. 766-777 ISSN 0165-0114 R&D Projects: GA ČR GA402/08/0618 Institutional research plan: CEZ:AV0Z10750506 Keywords : Aggregation functions * Associativity * Bisymmetry * Migrativity * Nullnorms * t-Norms * Uninorms Subject RIV: BA - General Mathematics Impact factor: 2.138, year: 2009 http://library.utia.cas.cz/separaty/2009/E/masiar-migrativityofaggregationfunctions.pdf

  17. Peroxisome Biogenesis and Function

    OpenAIRE

    Kaur, Navneet; Reumann, Sigrun; Hu, Jianping

    2009-01-01

    Peroxisomes are small and single membrane-delimited organelles that execute numerous metabolic reactions and have pivotal roles in plant growth and development. In recent years, forward and reverse genetic studies along with biochemical and cell biological analyses in Arabidopsis have enabled researchers to identify many peroxisome proteins and elucidate their functions. This review focuses on the advances in our understanding of peroxisome biogenesis and metabolism, and further explores the ...

  18. Functional organic thin films

    OpenAIRE

    Scharnberg, Michael

    2007-01-01

    Organic thin films are used in many technological and engineering applications nowadays. They find use as coatings, sensors, detectors, as matrix materials in nanocomposites, as self-assembled monolayers for surface functionalization, as low-k dielectrics in integrated circuits and in advanced organic electronic applications like organic light emitting diodes, organic field effect transistors and organic photovoltaics (esp. organic solar cells) and many other applications. OLED displays are n...

  19. Cybernetic functioning in stuttering

    Directory of Open Access Journals (Sweden)

    Ursula Zsilavecz

    1981-11-01

    Full Text Available The aim of this study was to evaluate different kinds of masking noise and DAF, in order to identify the condition which would elicit the highest incidence of fluency in a group of stutterers. The study demonstrates that masking noise and DAF can be effectively applied as an aid in a therapy programme, viz. noise can effectively be put to use so as to encourage and reinforce somesthesia. Stuttering is viewed as defective functioning in the cybernetic system.

  20. Engineering functional bladder tissues.

    Science.gov (United States)

    Horst, Maya; Madduri, Srinivas; Gobet, Rita; Sulser, Tullio; Milleret, Vinzent; Hall, Heike; Atala, Anthony; Eberli, Daniel

    2013-07-01

    End stage bladder disease can seriously affect patient quality of life and often requires surgical reconstruction with bowel tissue, which is associated with numerous complications. Bioengineering of functional bladder tissue using tissue-engineering techniques could provide new functional tissues for reconstruction. In this review, we discuss the current state of this field and address different approaches to enable physiologic voiding in engineered bladder tissues in the near future. In a collaborative effort, we gathered researchers from four institutions to discuss the current state of functional bladder engineering. A MEDLINE® and PubMed® search was conducted for articles related to tissue engineering of the bladder, with special focus on the cells and biomaterials employed as well as the microenvironment, vascularisation and innervation strategies used. Over the last decade, advances in tissue engineering technology have laid the groundwork for the development of a biological substitute for bladder tissue that can support storage of urine and restore physiologic voiding. Although many researchers have been able to demonstrate the formation of engineered tissue with a structure similar to that of native bladder tissue, restoration of physiologic voiding using these constructs has never been demonstrated. The main issues hindering the development of larger contractile tissues that allow physiologic voiding include the development of correct muscle alignment, proper innervation and vascularization. Tissue engineering of a construct that will support the contractile properties that allow physiologic voiding is a complex process. The combination of smart scaffolds with controlled topography, the ability to deliver multiple trophic factors and an optimal cell source will allow for the engineering of functional bladder tissues in the near future. Copyright © 2012 John Wiley & Sons, Ltd.

  1. Hexagonalization of correlation functions

    International Nuclear Information System (INIS)

    Fleury, Thiago; Komatsu, Shota

    2017-01-01

    We propose a nonperturbative framework to study general correlation functions of single-trace operators in N=4 supersymmetric Yang-Mills theory at large N. The basic strategy is to decompose them into fundamental building blocks called the hexagon form factors, which were introduced earlier to study structure constants using integrability. The decomposition is akin to a triangulation of a Riemann surface, and we thus call it hexagonalization. We propose a set of rules to glue the hexagons together based on symmetry, which naturally incorporate the dependence on the conformal and the R-symmetry cross ratios. Our method is conceptually different from the conventional operator product expansion and automatically takes into account multi-trace operators exchanged in OPE channels. To illustrate the idea in simple set-ups, we compute four-point functions of BPS operators of arbitrary lengths and correlation functions of one Konishi operator and three short BPS operators, all at one loop. In all cases, the results are in perfect agreement with the perturbative data. We also suggest that our method can be a useful tool to study conformal integrals, and show it explicitly for the case of ladder integrals.

  2. Hexagonalization of correlation functions

    Energy Technology Data Exchange (ETDEWEB)

    Fleury, Thiago [Instituto de Física Teórica, UNESP - University Estadual Paulista,ICTP South American Institute for Fundamental Research,Rua Dr. Bento Teobaldo Ferraz 271, 01140-070, São Paulo, SP (Brazil); Komatsu, Shota [Perimeter Institute for Theoretical Physics,31 Caroline St N Waterloo, Ontario N2L 2Y5 (Canada)

    2017-01-30

    We propose a nonperturbative framework to study general correlation functions of single-trace operators in N=4 supersymmetric Yang-Mills theory at large N. The basic strategy is to decompose them into fundamental building blocks called the hexagon form factors, which were introduced earlier to study structure constants using integrability. The decomposition is akin to a triangulation of a Riemann surface, and we thus call it hexagonalization. We propose a set of rules to glue the hexagons together based on symmetry, which naturally incorporate the dependence on the conformal and the R-symmetry cross ratios. Our method is conceptually different from the conventional operator product expansion and automatically takes into account multi-trace operators exchanged in OPE channels. To illustrate the idea in simple set-ups, we compute four-point functions of BPS operators of arbitrary lengths and correlation functions of one Konishi operator and three short BPS operators, all at one loop. In all cases, the results are in perfect agreement with the perturbative data. We also suggest that our method can be a useful tool to study conformal integrals, and show it explicitly for the case of ladder integrals.

  3. [Endocrine function in obesity].

    Science.gov (United States)

    Álvarez-Castro, Paula; Sangiao-Alvarellos, Susana; Brandón-Sandá, Iria; Cordido, Fernando

    2011-10-01

    Obesity is associated to significant disturbances in endocrine function. Hyper insulinemia and insulin resistance are the best known changes in obesity, but their mechanisms and clinical significance are not clearly established. Adipose tissue is considered to be a hormone-secreting endocrine organ; and increased leptin secretion from the adipocyte, a satiety signal, is a well-established endocrine change in obesity. In obesity there is a decreased GH secretion. Impairment of somatotropic function in obesity is functional and may be reversed in certain circumstances. The pathophysiological mechanism responsible for low GH secretion in obesity is probably multifactorial. There are many data suggesting that a chronic state of somatostatin hypersecretion results in inhibition of GH release. Increased FFA levels, as well as a deficient ghrelin secretion, probably contribute to the impaired GH secretion. In women, abdominal obesity is associated to hyperandrogenism and low sex hormone-binding globulin levels. Obese men, particularly those with morbid obesity, have decreased testosterone and gonadotropin levels. Obesity is associated to an increased cortisol production rate, which is compensated for by a higher cortisol clearance, resulting in plasma free cortisol levels that do not change when body weight increases. Ghrelin is the only known circulating orexigenic factor, and has been found to be decreased in obese people. In obesity there is also a trend to increased TSH and free T3 levels. Copyright © 2011 SEEN. Published by Elsevier Espana. All rights reserved.

  4. Carbasugars: Synthesis and Functions

    Science.gov (United States)

    Kobayashi, Yoshiyuki

    It is well recognized that glycosidase inhibitors are not only tools to elucidate the mechanism of a living system manipulated by glycoconjugates but also potential clinical drugs and insecticides by inducing the failure of glycoconjugates to perform their function. In this chapter, the syntheses and functions of natural glycosidase inhibitors (cyclophelitol , allosamidine , and trehazoilin ), which possess highly oxygenated and functionalized cyclohexanes or cyclopentanes in their structures and are defined as carbasugars , and the structure and activity relationships (SAR) of their derivatives are described. Also, recently much attention has been focused on neuraminidase inhibitors as anti-influenza drugs since relenza , which was derived from sialic acid, and also, tamiflu , which is the artificial carbasugar designed as a transition state analogue in the hydrolysis pathway of substrates by neuraminidase, were launched in the market. Herein, the medicinal chemistry efforts to discover tamiflu and some efficient syntheses applicable to process chemistry are described. Finally, useful synthetic methodologies for carbasugar formation from sugars are also introduced in this chapter.

  5. Lutein and Brain Function

    Directory of Open Access Journals (Sweden)

    John W. Erdman

    2015-10-01

    Full Text Available Lutein is one of the most prevalent carotenoids in nature and in the human diet. Together with zeaxanthin, it is highly concentrated as macular pigment in the foveal retina of primates, attenuating blue light exposure, providing protection from photo-oxidation and enhancing visual performance. Recently, interest in lutein has expanded beyond the retina to its possible contributions to brain development and function. Only primates accumulate lutein within the brain, but little is known about its distribution or physiological role. Our team has begun to utilize the rhesus macaque (Macaca mulatta model to study the uptake and bio-localization of lutein in the brain. Our overall goal has been to assess the association of lutein localization with brain function. In this review, we will first cover the evolution of the non-human primate model for lutein and brain studies, discuss prior association studies of lutein with retina and brain function, and review approaches that can be used to localize brain lutein. We also describe our approach to the biosynthesis of 13C-lutein, which will allow investigation of lutein flux, localization, metabolism and pharmacokinetics. Lastly, we describe potential future research opportunities.

  6. Multilevel functional clustering analysis.

    Science.gov (United States)

    Serban, Nicoleta; Jiang, Huijing

    2012-09-01

    In this article, we investigate clustering methods for multilevel functional data, which consist of repeated random functions observed for a large number of units (e.g., genes) at multiple subunits (e.g., bacteria types). To describe the within- and between variability induced by the hierarchical structure in the data, we take a multilevel functional principal component analysis (MFPCA) approach. We develop and compare a hard clustering method applied to the scores derived from the MFPCA and a soft clustering method using an MFPCA decomposition. In a simulation study, we assess the estimation accuracy of the clustering membership and the cluster patterns under a series of settings: small versus moderate number of time points; various noise levels; and varying number of subunits per unit. We demonstrate the applicability of the clustering analysis to a real data set consisting of expression profiles from genes activated by immunity system cells. Prevalent response patterns are identified by clustering the expression profiles using our multilevel clustering analysis. © 2012, The International Biometric Society.

  7. Functions of multivector variables.

    Directory of Open Access Journals (Sweden)

    James M Chappell

    Full Text Available As is well known, the common elementary functions defined over the real numbers can be generalized to act not only over the complex number field but also over the skew (non-commuting field of the quaternions. In this paper, we detail a number of elementary functions extended to act over the skew field of Clifford multivectors, in both two and three dimensions. Complex numbers, quaternions and Cartesian vectors can be described by the various components within a Clifford multivector and from our results we are able to demonstrate new inter-relationships between these algebraic systems. One key relationship that we discover is that a complex number raised to a vector power produces a quaternion thus combining these systems within a single equation. We also find a single formula that produces the square root, amplitude and inverse of a multivector over one, two and three dimensions. Finally, comparing the functions over different dimension we observe that Cl(R(3 provides a particularly versatile algebraic framework.

  8. [Functional hypothalamic amenorrhea].

    Science.gov (United States)

    Stárka, Luboslav; Dušková, Michaela

    2015-10-01

    Functional hypothalamic amenorrhea (FHA) besides pregnancy and syndrome of polycystic ovary is one of the most common causes of secondary amenorrhea. FHA results from the aberrations in pulsatile gonadotropin-releasing hormone (GnRH) secretion, which in turn causes impairment of the gonadotropins (follicle-stimulating hormone and luteinizing hormone). FHA is a form of the defence of organism in situations where life functions are more important than reproductive function. FHA is reversible; it can be normalized after ceasing the stress situation. There are three types of FHA: weight loss related, stress-related, and exercise-related amenorrhea. The final consequences are complex hormonal changes manifested by profound hypoestrogenism. Additionally, these patients present mild hypercortisolemia, low serum insulin levels, low insulin-like growth factor 1 (IGF-1) and low total triiodothyronine. Women health in this disorder is disturbed in several aspects including the skeletal system, cardiovascular system, and mental problems. Patients manifest a decrease in bone mass density, which is related to an increase in fracture risk. Therefore, osteopenia and osteoporosis are the main long-term complications of FHA. Cardiovascular complications include endothelial dysfunction and abnormal changes in the lipid profile. FHA patients present significantly higher depression and anxiety and also sexual problems compared to healthy subjects.

  9. Orexins and gastrointestinal functions.

    Science.gov (United States)

    Baccari, M C

    2010-03-01

    Orexin A (OXA) and orexin B (OXB) are recently discovered neuropeptides that appear to play a role in various distinct functions such as arousal and the sleep-wake cycle as well as on appetite and regulation of feeding and energy homeostasis. Orexins were first described as neuropeptides expressed by a specific population of neurons in the lateral hypothalamic area, a region classically implicated in feeding behaviour. Orexin neurons project to numerous brain regions, where orexin receptors have been shown to be widely distributed: both OXA and OXB act through two subtypes of receptors (OX1R and OX2R) that belong to the G protein-coupled superfamily of receptors. Growing evidence indicates that orexins act in the central nervous system also to regulate gastrointestinal functions: animal studies have indeed demonstrated that centrally-injected orexins or endogenously released orexins in the brain stimulates gastric secretion and influence gastrointestinal motility. The subsequent identification of orexins and their receptors in the enteric nervous system (including the myenteric and the submucosal plexuses) as well as in mucosa and smooth muscles has suggested that these neuropeptides may also play a local action. In this view, emerging studies indicate that orexins also exert region-specific contractile or relaxant effects on isolated gut preparations. The aim of the proposed review is to summarize both centrally- and peripherally-mediated actions of orexins on gastrointestinal functions and to discuss the related physiological role on the basis of the most recent findings.

  10. A functional RG equation for the c-function

    DEFF Research Database (Denmark)

    Codello, A.; D'Odorico, G.; Pagani, C.

    2014-01-01

    , local potential approximation and loop expansion. In each case we construct the relative approximate c-function and find it to be consistent with Zamolodchikov's c-theorem. Finally, we present a relation between the c-function and the (matter induced) beta function of Newton's constant, allowing us...... to use heat kernel techniques to compute the RG running of the c-function....

  11. Strange functions in real analysis

    CERN Document Server

    Kharazishvili, AB

    2005-01-01

    Weierstrass and Blancmange nowhere differentiable functions, Lebesgue integrable functions with everywhere divergent Fourier series, and various nonintegrable Lebesgue measurable functions. While dubbed strange or "pathological," these functions are ubiquitous throughout mathematics and play an important role in analysis, not only as counterexamples of seemingly true and natural statements, but also to stimulate and inspire the further development of real analysis.Strange Functions in Real Analysis explores a number of important examples and constructions of pathological functions. After introducing the basic concepts, the author begins with Cantor and Peano-type functions, then moves to functions whose constructions require essentially noneffective methods. These include functions without the Baire property, functions associated with a Hamel basis of the real line, and Sierpinski-Zygmund functions that are discontinuous on each subset of the real line having the cardinality continuum. Finally, he considers e...

  12. Microbial Functional Gene Diversity Predicts Groundwater Contamination and Ecosystem Functioning.

    Science.gov (United States)

    He, Zhili; Zhang, Ping; Wu, Linwei; Rocha, Andrea M; Tu, Qichao; Shi, Zhou; Wu, Bo; Qin, Yujia; Wang, Jianjun; Yan, Qingyun; Curtis, Daniel; Ning, Daliang; Van Nostrand, Joy D; Wu, Liyou; Yang, Yunfeng; Elias, Dwayne A; Watson, David B; Adams, Michael W W; Fields, Matthew W; Alm, Eric J; Hazen, Terry C; Adams, Paul D; Arkin, Adam P; Zhou, Jizhong

    2018-02-20

    Contamination from anthropogenic activities has significantly impacted Earth's biosphere. However, knowledge about how environmental contamination affects the biodiversity of groundwater microbiomes and ecosystem functioning remains very limited. Here, we used a comprehensive functional gene array to analyze groundwater microbiomes from 69 wells at the Oak Ridge Field Research Center (Oak Ridge, TN), representing a wide pH range and uranium, nitrate, and other contaminants. We hypothesized that the functional diversity of groundwater microbiomes would decrease as environmental contamination (e.g., uranium or nitrate) increased or at low or high pH, while some specific populations capable of utilizing or resistant to those contaminants would increase, and thus, such key microbial functional genes and/or populations could be used to predict groundwater contamination and ecosystem functioning. Our results indicated that functional richness/diversity decreased as uranium (but not nitrate) increased in groundwater. In addition, about 5.9% of specific key functional populations targeted by a comprehensive functional gene array (GeoChip 5) increased significantly ( P contamination and ecosystem functioning. This study indicates great potential for using microbial functional genes to predict environmental contamination and ecosystem functioning. IMPORTANCE Disentangling the relationships between biodiversity and ecosystem functioning is an important but poorly understood topic in ecology. Predicting ecosystem functioning on the basis of biodiversity is even more difficult, particularly with microbial biomarkers. As an exploratory effort, this study used key microbial functional genes as biomarkers to provide predictive understanding of environmental contamination and ecosystem functioning. The results indicated that the overall functional gene richness/diversity decreased as uranium increased in groundwater, while specific key microbial guilds increased significantly as

  13. Keep wetlands wet: the myth of sustainable development of tropical peatlands - implications for policies and management.

    Science.gov (United States)

    Evers, Stephanie; Yule, Catherine M; Padfield, Rory; O'Reilly, Patrick; Varkkey, Helena

    2017-02-01

    Pristine tropical peat swamp forests (PSFs) represent a unique wetland ecosystem of distinctive hydrology which support unique biodiversity and globally significant stores of soil carbon. Yet in Indonesia and Malaysia, home to 56% of the world's tropical peatland, they are subject to considerable developmental pressures, including widespread drainage to support agricultural needs. In this article, we review the ecology behind the functioning and ecosystem services provided by PSFs, with a particular focus on hydrological processes as well as the role of the forest itself in maintaining those services. Drawing on this, we review the suitability of current policy frameworks and consider the efficacy of their implementation. We suggest that policies in Malaysia and Indonesia are often based around the narrative of oil palm and other major monocrops as drivers of prosperity and development. However, we also argue that this narrative is also being supported by a priori claims concerning the possibility of sustainability of peat swamp exploitation via drainage-based agriculture through the adherence to best management practices. We discuss how this limits their efficacy, uptake and the political will towards enforcement. Further, we consider how both narratives (prosperity and sustainability) clearly exclude important considerations concerning the ecosystem value of tropical PSFs which are dependent on their unimpacted hydrology. Current research clearly shows that the actual debate should be focused not on how to develop drainage-based plantations sustainably, but on whether the sustainable conversion to drainage-based systems is possible at all. © 2016 John Wiley & Sons Ltd.

  14. Functional Foods for Women's Health.

    Science.gov (United States)

    Lindeman, Alice K.

    2002-01-01

    Describes functional foods for women's health (foods or food ingredients that provide health benefits beyond basic nutrition), explaining that both whole and modified foods can be included as functional foods. The paper discusses the history, regulation, and promotion of functional foods; consumer interest in functional foods; how to incorporate…

  15. [Functional heart pain].

    Science.gov (United States)

    Grabhorn, Ralph; Jordan, Jochen

    2004-09-01

    Functional heart symptoms, especially chest pain, are very widespread and, according to the International Classification of Diseases (ICD-10), are described as "somatoform autonomous functional disorders of the cardiovascular system". Although they are very often accompanied by considerable anxiety about having a heart attack, for example, they are initially not recognizable as such and have to be distinguished from somatic complaints. The most prevalent of these symptoms (Table 2) are chest pains, followed by feelings of weakness, a tendency to become easily fatigued and breathing difficulties. The perception of changes in cardiac activity, such as tachycardia, heart palpitations, irregular heartbeat or arrhythmias, is also extremely unsettling and thus anxiety-provoking. Therefore, although a responsible cardiac diagnosis is the basis for every further step taken, it is advisable to carry out a brief anamnesis immediately, if possible, to determine the prior history (Table 1). For example, previously conducted clarification of somatic causes, consultations with more than one physician in parallel or repeated medical emergency calls can be helpful for orientation. Moreover, in the interview during the diagnostic measures, the possibility of functional causes should always be pointed out in order to counteract a somatic fixation early on. The health-care policy role that lies in early diagnosis of functional cardiac complaints has to be regarded as highly relevant. Following exclusionary diagnosis, the patients should not be discharged as "healthy" from the cardiological practice without a more in-depth anamnesis of their complaints, because differentiated questioning of the patient not only about typical physical and psychic symptoms, but also about behavior patterns (Table 3) that can accompany functional cardiac complaints, works in favor of a doctor-patient relationship that is based on trust. Since, in addition to anxiety disorders, above all depressive states

  16. Bioinspired, functional nanoscale materials

    Science.gov (United States)

    Jun, In-Kook

    Functional nanomaterials in nature exhibit many unique functions and optical and mechanical properties. Examples of this include the dry adhesion of a gecko's foot, the reduced drag on a shark's skin, the high strength and toughness of nacre, and the superhydrophobic self-cleaning of a lotus leaf. This dissertation is devoted to creating unique and enhanced properties by mimicking such functional materials. We have developed a novel self-pumping membrane, which does not require an applied voltage. The self-pumping membrane harvests chemical energy from a surrounding fluid and uses it for accelerated mass transport across the membrane. A device such as this has promising applications in implantable or remotely operating autonomous devices and membrane-based purification systems. Reproducible and highly active surface enhanced Raman scattering (SERS) substrates were developed using a bottom-up self-assembly technology. With their high sensitivity and good reproducibility, the developed nanostructures (gold nanoparticle and nanohole arrays) as SERS substrates are very promising for applications such as ultra-sensitive detectors for chemicals and reproducible sensors for chemical and biological molecules. Binary colloidal crystals were created using a simple, fast, and scalable spin-coating technology. Although further investigation of the procedure is needed to improve the ordering of particles in the individual layers, the developed assembly technology has a promising outlook in applications such as optical integrated circuits and high-speed optical computing. Inorganic-organic nanocomposites were realized by assembling synthesized gibbsite nanoplatelets using the electrophoretic deposition and infiltration of a monomer followed by polymerization. Via surface modifications of gibbsite nanoplatelets, nanocomposites were further reinforced with covalent linkages between the inorganic platelets and organic matrix.

  17. Defining functional dyspepsia.

    Science.gov (United States)

    Mearin, Fermín; Calleja, José Luis

    2011-12-01

    Dyspepsia and functional dyspepsia represent a highly significant public health issue. A good definition of dyspepsia is key for helping us to better approach symptoms, decision making, and therapy indications.During the last few years many attempts were made at establishing a definition of dyspepsia. Results were little successful on most occasions, and clear discrepancies arose on whether symptoms should be associated with digestion, which types of symptoms were to be included, which anatomic location should symptoms have, etc.The Rome III Committee defined dyspepsia as "a symptom or set of symptoms that most physicians consider to originate from the gastroduodenal area", including the following: postprandial heaviness, early satiety, and epigastric pain or burning. Two new entities were defined: a) food-induced dyspeptic symptoms (postprandial distress syndrome); and b) epigastric pain (epigastric pain syndrome). These and other definitions have shown both strengths and weaknesses. At times they have been much too complex, at times much too simple; furthermore, they have commonly erred on the side of being inaccurate and impractical. On the other hand, some (the most recent ones) are difficult to translate into the Spanish language. In a meeting of gastroenterologists with a special interest in digestive functional disorders, the various aspects of dyspepsia definition were discussed and put to the vote, and the following conclusions were arrived at: dyspepsia is defined as a set of symptoms, either related or unrelated to food ingestion, localized on the upper half of the abdomen. They include: a) epigastric discomfort (as a category of severity) or pain; b) postprandial heaviness; and c) early satiety. Associated complaints include: nausea, belching, bloating, and epigastric burn (heartburn). All these must be scored according to severity and frequency. Furthermore, psychological factors may be involved in the origin of functional dyspepsia. On the other hand

  18. Neurophysiology of functional imaging.

    Science.gov (United States)

    van Eijsden, Pieter; Hyder, Fahmeed; Rothman, Douglas L; Shulman, Robert G

    2009-05-01

    The successes of PET and fMRI in non-invasively localizing sensory functions had encouraged efforts to transform the subjective concepts of cognitive psychology into objective physical measures. The assumption was that mental functions could be decomposed into non-overlapping, context-independent modules that are operated on by separable areas of a computer-like brain. The failures of cognitive modularity and of a very localized phrenology are generally, but not universally, accepted; but in their place, and usually not distinguished from the original revolutionary hopes of clarification, experimental results are being interpreted in terms of rather flexible definitions of both cognitive concepts and the degree of localization. In an alternative approach, we have connected fMRI, (13)C MRS, and electrophysiology measurements of brain energy to connect with observable properties of mental life (i.e., awareness). We illustrate this approach with a sensory stimulation experiment; the degree of localization found in BOLD signals was related to the global energy of the brain which, when manipulated by anesthetics, affected the degree of awareness. The influence of brain energy upon functional imaging maps is changing the interpretations of neuroimaging experiments, from psychological concepts generating computer-like responses to empirical responses dominated by the high brain energy and signaling at rest. In our view "baseline" is an operational term, an adjective that defines a property of a state of the system before it is perturbed by a stimulus. Given the dependence of observable psychological properties upon the "baseline" energy, we believe that it is unnecessarily limiting to define a particular state as the baseline.

  19. Perioperative functional residual capacity.

    Science.gov (United States)

    Wahba, R W

    1991-04-01

    The literature dealing with the magnitude, mechanism and effects of reduced FRC in the perioperative period is reviewed. During general anaesthesia FRC is reduced by approximately 20%. The reduction is greater in the obese and in patients with COPD. The most likely mechanism is the loss of inspiratory muscle tone of the muscles acting on the rib cage. Gas trapping is an additional mechanism. Lung compliance decreases and airways resistance increases, in large part, due to decreased FRC. The larynx is displaced anteriorly and elongated, making laryngoscopy and intubation more difficult. The change in FRC creates or increases intrapulmonary shunt and areas of low ventilation to perfusion. This is due to the occurrence of compression atelectasis, and to regional changes in mechanics and airway closure which tend to reduce ventilation to dependent lung zones which are still well perfused. Abdominal and thoracic operations tend to increase shunting further. Large tidal volume but not PEEP will improve oxygenation, although both increase FRC. Both FRC and vital capacity are reduced following abdominal and thoracic surgery in a predictable pattern. The mechanism is the combined effect of incisional pain and reflex dysfunction of the diaphragm. Additional effects of thoracic surgery include pleural effusion, cooling of the phrenic nerve and mediastinal widening. Postoperative hypoxaemia is a function of reduced FRC and airway closure. There is no real difference among the various methods of active lung expansion in terms of the speed of restoration of lung function, or in preventing postoperative atelectasis/pneumonia. Epidural analgesia does not influence the rate of recovery of lung function, nor does it prevent atelectasis/pneumonia.

  20. DNA: Structure and function

    DEFF Research Database (Denmark)

    Sinden, Richard R.; E. Pearson, Christopher; N. Potaman, Vladimir

    1998-01-01

    This chapter discusses the structure and function of DNA. DNA occupies a critical role in cells, because it is the source of all intrinsic genetic information. Chemically, DNA is a very stable molecule, a characteristic important for a macromolecule that may have to persist in an intact form...... for a long period of time before its information is accessed by the cell. Although DNA plays a critical role as an informational storage molecule, it is by no means as unexciting as a computer tape or disk drive. The structure of the DNA described by Watson and Crick in 1953 is a right handed helix of two...

  1. Matrix string partition function

    CERN Document Server

    Kostov, Ivan K; Kostov, Ivan K.; Vanhove, Pierre

    1998-01-01

    We evaluate quasiclassically the Ramond partition function of Euclidean D=10 U(N) super Yang-Mills theory reduced to a two-dimensional torus. The result can be interpreted in terms of free strings wrapping the space-time torus, as expected from the point of view of Matrix string theory. We demonstrate that, when extrapolated to the ultraviolet limit (small area of the torus), the quasiclassical expressions reproduce exactly the recently obtained expression for the partition of the completely reduced SYM theory, including the overall numerical factor. This is an evidence that our quasiclassical calculation might be exact.

  2. Fabrics in Function

    DEFF Research Database (Denmark)

    Bang, Anne Louise

    2007-01-01

    to the establishment of an initial framework for the project it has a focus on how to explore costumers and users emotional experiences with fabrics. The three year research project is based on experimental design research and the textile designer's competences and knowledge. During the research project exploring...... sensing of fabrics in function. It is proposed that tactile and visual sensing of fabrics is a way to investigate and express emotional utility values. The further purpose is to use experiments with repertory grid models as part of the mapping of the entire research project and also as a basis...

  3. Functions and graphs

    CERN Document Server

    Gelfand, I M; Shnol, E E

    1969-01-01

    The second in a series of systematic studies by a celebrated mathematician I. M. Gelfand and colleagues, this volume presents students with a well-illustrated sequence of problems and exercises designed to illuminate the properties of functions and graphs. Since readers do not have the benefit of a blackboard on which a teacher constructs a graph, the authors abandoned the customary use of diagrams in which only the final form of the graph appears; instead, the book's margins feature step-by-step diagrams for the complete construction of each graph. The first part of the book employs simple fu

  4. Early Functional Abilities

    DEFF Research Database (Denmark)

    Lorentzen, Jakob; Poulsen, Ingrid

    2005-01-01

    deltager i teamet omkring patientens rehabilitering og består af fire funktionsområder, der hver især har underpunkter (items): Det vegetative system: sygeplejepersonale (fire items) Facio-oral function: ergoterapeut, logopæd, sygeplejepersonale (fire items) Sensomotorisk funktion: fysioterapeuter (syv...... items) Kognitiv funktion: ergoterapeut, neuropsykolog (fem items) De fire områder reflekterer ifølge kildematerialet de områder, der er centrale at vurdere som tidlige funktionelle færdigheder for den senhjerneskadede patient (ikke medfødte hjerneskader), og som netop skulle gøre at responsen på den...

  5. The hash function BLAKE

    CERN Document Server

    Aumasson, Jean-Philippe; Phan, Raphael; Henzen, Luca

    2014-01-01

    This is a comprehensive description of the cryptographic hash function BLAKE, one of the five final contenders in the NIST SHA3 competition, and of BLAKE2, an improved version popular among developers. It describes how BLAKE was designed and why BLAKE2 was developed, and it offers guidelines on implementing and using BLAKE, with a focus on software implementation.   In the first two chapters, the authors offer a short introduction to cryptographic hashing, the SHA3 competition, and BLAKE. They review applications of cryptographic hashing, they describe some basic notions such as security de

  6. Notes on functional analysis

    CERN Document Server

    Bhatia, Rajendra

    2009-01-01

    These notes are a record of a one semester course on Functional Analysis given by the author to second year Master of Statistics students at the Indian Statistical Institute, New Delhi. Students taking this course have a strong background in real analysis, linear algebra, measure theory and probability, and the course proceeds rapidly from the definition of a normed linear space to the spectral theorem for bounded selfadjoint operators in a Hilbert space. The book is organised as twenty six lectures, each corresponding to a ninety minute class session. This may be helpful to teachers planning a course on this topic. Well prepared students can read it on their own.

  7. Functional and Operatorial Statistics

    CERN Document Server

    Dabo-niang, Sophie

    2008-01-01

    An increasing number of statistical problems and methods involve infinite-dimensional aspects. This is due to the progress of technologies which allow us to store more and more information while modern instruments are able to collect data much more effectively due to their increasingly sophisticated design. This evolution directly concerns statisticians, who have to propose new methodologies while taking into account such high-dimensional data (e.g. continuous processes, functional data, etc.). The numerous applications (micro-arrays, paleo- ecological data, radar waveforms, spectrometric curv

  8. Pfaff tau functions

    OpenAIRE

    Adler, M.; Shiota, T.; Van Moerbeke, Pierre

    1999-01-01

    Consider the evolution $$ \\frac{\\pl m_\\iy}{\\pl t_n}=\\Lb^n m_\\iy, \\frac{\\pl m_\\iy}{\\pl s_n}=-m_\\iy(\\Lb^\\top)^n, $$ on bi- or semi-infinite matrices $m_\\iy=m_\\iy(t,s)$, with skew-symmetric initial data $m_{\\iy}(0,0)$. Then, $m_\\iy(t,-t)$ is skew-symmetric, and so the determinants of the successive "upper-left corners" vanish or are squares of Pfaffians. In this paper, we investigate the rich nature of these Pfaffians, as functions of t. This problem is motivated by questions c...

  9. Functional Constipation in Pediatrics

    Directory of Open Access Journals (Sweden)

    Luis De la Torre Mondragón

    2014-10-01

    Full Text Available Constipation is a common disease and one of the most frequent reasons of visits in pediatric clinics, complications related to constipation denote an inadequate diagnosis and/or treatment. This article is addressed for physicians who provide care to children with functional constipation and, it proposes in a practical manner how to diagnose this problem, emphasizing the essential information that should be obtained from the clinical history and from the workup helpful for its diagnosis. The “bowel management program” is the proposed treatment; this pro- gram has a rate success higher than 90%, even, in patients with severe chronic constipation with frequent relapses and multiple treatments.

  10. Ramanujan's mock theta functions.

    Science.gov (United States)

    Griffin, Michael; Ono, Ken; Rolen, Larry

    2013-04-09

    In his famous deathbed letter, Ramanujan introduced the notion of a mock theta function, and he offered some alleged examples. Recent work by Zwegers [Zwegers S (2001) Contemp Math 291:268-277 and Zwegers S (2002) PhD thesis (Univ of Utrecht, Utrecht, The Netherlands)] has elucidated the theory encompassing these examples. They are holomorphic parts of special harmonic weak Maass forms. Despite this understanding, little attention has been given to Ramanujan's original definition. Here, we prove that Ramanujan's examples do indeed satisfy his original definition.

  11. Plasmodesmata: Structure and Function

    Directory of Open Access Journals (Sweden)

    Thomas David Geydan

    2006-07-01

    Full Text Available Plasmodesmata are channels that transverse the cell wall and membrane. These specialized and non passive channels act like gates that facilitate and regulate both communication and transportation of molecules such as water, nutrients, metabolites and macromolecules between plant cells. In the last decade a new point of view of plasmodesmata has emerged, and studies have  demonstrated that these channels are more complex. In this brief note, we pretend to expose the actual knowledge of plasmodesmata, focusing on their structure and function.

  12. Varicocele and testicular function

    Directory of Open Access Journals (Sweden)

    Alexander W Pastuszak

    2015-01-01

    Full Text Available Testicular varicocele, a dilation of the veins of the pampiniform plexus thought to increase testicular temperature via venous congestion, is commonly associated with male infertility. Significant study has clarified the negative impact of varicocele on semen parameters and more recent work has shed light on its detrimental effects on the molecular and ultrastructural features of sperm and the testicular microenvironment, as well as more clearly defined the positive impacts of treatment on couples′ fertility. The relationship between varicocele and testicular endocrine function, while known for some time based on histologic evaluation, has become more apparent in the clinical setting with a growing link between varicocele and hypogonadism. Finally, in the pediatric setting, while future study will clarify the impact of varicocele on fertility and testicular function, recent work supports a parallel effect of varicocele in adolescents and adults, suggesting a re-evaluation of current treatment approaches in light of the progressive nature of the condition and potential increased risk of future disease.

  13. Mast Cell Function

    Science.gov (United States)

    da Silva, Elaine Zayas Marcelino; Jamur, Maria Célia

    2014-01-01

    Since first described by Paul Ehrlich in 1878, mast cells have been mostly viewed as effectors of allergy. It has been only in the past two decades that mast cells have gained recognition for their involvement in other physiological and pathological processes. Mast cells have a widespread distribution and are found predominantly at the interface between the host and the external environment. Mast cell maturation, phenotype and function are a direct consequence of the local microenvironment and have a marked influence on their ability to specifically recognize and respond to various stimuli through the release of an array of biologically active mediators. These features enable mast cells to act as both first responders in harmful situations as well as to respond to changes in their environment by communicating with a variety of other cells implicated in physiological and immunological responses. Therefore, the critical role of mast cells in both innate and adaptive immunity, including immune tolerance, has gained increased prominence. Conversely, mast cell dysfunction has pointed to these cells as the main offenders in several chronic allergic/inflammatory disorders, cancer and autoimmune diseases. This review summarizes the current knowledge of mast cell function in both normal and pathological conditions with regards to their regulation, phenotype and role. PMID:25062998

  14. Monopoles and Baker functions

    Science.gov (United States)

    Ercolani, N.; Sinha, A.

    1989-09-01

    The work in this paper pertains to the solutions of Nahm's equations, which arise in the Atiyah-Drinfield-Hitchin-Manin-Nahm construction of solutions to the Bogomol'nyi equations for static monopoles. This paper provides an explicit construction of the solution of Nahm's equations which satisfy regularity and reality conditions. The Lax form of Nahm's equations is reduced to a standard eigenvalue problem by a special gauge transformation. These equations may then be solved by the method of Baker-Krichever. This leads to a compact representation of the solutions of Nahm's equations. The regularity condition is shown to be related to the monodromy of the gauge reduced linear operator. Hitchin showed that the solutions of Nahm's equations can be characterized by an algebraic curve and some data on that curve. Here, this characterization reduces to a transcendental equation involving certain loop integrals of a meromorphic differential. Donaldson coordinatized the moduli space of k-monopoles by a class of rational maps from the Riemann sphere to itself. The data of a Baker function is equivalent to this map. This method gives an “apriori” construction of the (known) two monopole solutions. We also give a generalization of the two monopole solution to a class of elliptic solutions of arbitrary charge. These solutions correspond to reducible curves with elliptic components and the associated Donaldson rational function has a simple partial fraction expansion.

  15. Monopoles and Baker functions

    International Nuclear Information System (INIS)

    Ercolani, N.; Sinha, A.

    1989-01-01

    The work in this paper pertains to the solutions of Nahm's equations, which arise in the Atiyah-Drinfield-Hitchin-Manin-Nahm construction of solutions to the Bogomol'nyi equations for static monopoles. This paper provides an explicit construction of the solution of Nahm's equations which satisfy regularity and reality conditions. The Lax form of Nahm's equations is reduced to a standard eigenvalue problem by a special gauge transformation. These equations may then be solved by the method of Baker-Krichever. This leads to a compact representation of the solutions of Nahm's equations. The regularity condition is shown to be related to the monodromy of the gauge reduced linear operator. Hitchin showed that the solutions of Nahm's equations can be characterized by an algebraic curve and some data on that curve. Here, this characterization reduces to a transcendental equation involving certain loop integrals of a meromorphic differential. Donaldson coordinatized the moduli space of k-monopoles by a class of rational maps from the Riemann sphere to itself. The data of a Baker function is equivalent to this map. This method gives an 'apriori' construction of the (known) two monopole solutions. We also give a generalization of the two monopole solution to a class of elliptic solutions of arbitrary charge. These solutions correspond to reducible curves with elliptic components and the associated Donaldson rational function has a simple partial fraction expansion. (orig.)

  16. Menstrual function in sports.

    Science.gov (United States)

    Roupas, Nikolaos D; Georgopoulos, Neoklis A

    2011-01-01

    To highlight the recent developments in the field of menstrual function in sports and to provide an overview of our current understanding in regard to the pathophysiology, evaluation and management strategies of exercise-related reproductive dysfunction. A PUBMED search was carried out and all articles published from 1980 to 2010 with title words related to exercise, athletes, menstrual function and primary and secondary amenorrhea were reviewed. The review structure includes a pathophysiology overview, menstrual dysfunction among different athletic disciplines, clinical manifestations, evaluation and management strategies, with particular emphasis on recent data regarding the use of oral contraceptives and hormone replacement therapy. Exercise-related reproductive dysfunction appears to be multifactorial in origin and remains a diagnosis of exclusion. Recent findings underscore the endocrine role of adipose tissue in the regulation of metabolism and reproduction, providing further data on our understanding of the pathophysiology of exercise-related reproductive dysfunction. Clinical manifestations range from primary amenorrhea or delayed menarche to luteal phase deficiency, oligomenorrhea, anovulation and secondary amenorrhea. Amenorrhea constitutes the most serious clinical consequence and is associated with bone pathology. Early diagnosis, thorough evaluation and individualized management (ranging from diet and exercise, or behavior adjustments to pharmacologic treatment) should be achieved in order to preserve bone mass.

  17. Amusia and musical functioning.

    Science.gov (United States)

    Alossa, Nicoletta; Castelli, Lorys

    2009-01-01

    Music, as language, is a universal and specific trait to humans; it is a complex ability with characteristics that are unique compared to other cognitive abilities. Nevertheless, several issues are still open to debate, such as, for example, whether music is a faculty that is independent from the rest of the cognitive system, and whether musical skills are mediated by a single mechanism or by a combination of processes that are independent from one another. Moreover, the anatomical correlations of music have yet to be clarified. The goal of this review is to illustrate the current condition of the neuropsychology of music and to describe different approaches to the study of the musical functions. Hereby, we will describe the neuropsychological findings, suggesting that music is a special function carried out by different and dedicated processes that are probably subserved by different anatomical regions of the brain. Moreover, we will review the evidence obtained by working with brain-damaged patients suffering from music agnosia, a selective impairment in music recognition. Copyright 2009 S. Karger AG, Basel.

  18. ESD - FUNCTIONAL CLOTHING

    Directory of Open Access Journals (Sweden)

    SCARLAT Razvan

    2016-05-01

    Full Text Available The functional clothing represents a sustainable development direction of in the field of technical textiles, a bridge between various activity domains, a solution to user’s complex requirements. The research and development potential in the field is supported by the new fibers/ yarns generation, the new technologies and the market niches, as well. Protective clothing is now a major part of textile classified under technical textile. Protective clothing refers to the garment and other fabric related items designed to protect the wearer from harsh environmental effects that results in injuries or death. The innovation, as a result of convergence processing technologies, consumer demands and what is viable on the market, defines the personal protective equipment field. In this article, we present the work of an ESD protective clothing development. Therefore, it has been applied a modern knitting technology, on 7E and 12E STOLL machines, using cotton and wool yarns as base yarn and conductive yarns for plaiting structures. Also, the optimal parameters establishment and the functional requirements are aspects of the research activity performed. The experimental models have been conducted in order to demonstrate the design concept used and choosing the optimal variant. The characterization of the developed experimental variants took into account the evaluation of physico-mechanical and electrical characteristics. From the electrical point of view, the variants have been mainly evaluated through “point to point” method in terms of electrical isolation efficiency dimensional changes analysis.

  19. Verbal Functions in Psychopathy.

    Science.gov (United States)

    de Almeida Brites, José; Ladera, Valentina; Perea, Victoria; García, Ricardo

    2015-12-01

    The aim of this study was to compare the verbal functions and language skills of male psychopathic individuals (in prison and outside) with non-psychopaths. The purpose was therefore to analyze phonological processing, reading and writing skills, the meaning of words and images, and the understanding of sentences. Ninety individuals with an average age of 38.19 (SD = 7.67) voluntarily participated in this study. The data were collected in different settings: prisons, a private charitable organization, and private clinics and health centers. All participants completed the Psychopathy Checklist Revised and the Psycholinguistic Assessment of Language Processing in Aphasia, to assess psychopathy traits and language skills, respectively. Participants were allocated into four different groups: incarcerated psychopathic offenders (n = 13), non-incarcerated psychopathic non-offenders living in the community (n = 13), incarcerated non-psychopathic offenders (n = 25), and non-psychopathic non-offenders living in the community (n = 39). The results showed that the verbal functions and language skills between psychopaths and non-psychopaths are very similar, showing a common profile. The data presented indicate the need for more specific work opportunities for both groups within the correctional setting, with the use of appropriate language and individualized programs as necessary. © The Author(s) 2014.

  20. Construction of bent functions from near-bent functions

    DEFF Research Database (Denmark)

    Leander, Gregor; McGuire, G.

    2009-01-01

    We give a construction of bent functions in dimension 2m from near-bent functions in dimension 2m - 1. in particular, we give the first ever examples of non-weakly-normal bent functions in dimensions 10 and 12, which demonstrates the significance of our construction.......We give a construction of bent functions in dimension 2m from near-bent functions in dimension 2m - 1. in particular, we give the first ever examples of non-weakly-normal bent functions in dimensions 10 and 12, which demonstrates the significance of our construction....

  1. Functionally Graded Materials Database

    Science.gov (United States)

    Kisara, Katsuto; Konno, Tomomi; Niino, Masayuki

    2008-02-01

    Functionally Graded Materials Database (hereinafter referred to as FGMs Database) was open to the society via Internet in October 2002, and since then it has been managed by the Japan Aerospace Exploration Agency (JAXA). As of October 2006, the database includes 1,703 research information entries with 2,429 researchers data, 509 institution data and so on. Reading materials such as "Applicability of FGMs Technology to Space Plane" and "FGMs Application to Space Solar Power System (SSPS)" were prepared in FY 2004 and 2005, respectively. The English version of "FGMs Application to Space Solar Power System (SSPS)" is now under preparation. This present paper explains the FGMs Database, describing the research information data, the sitemap and how to use it. From the access analysis, user access results and users' interests are discussed.

  2. Functional memory metals

    International Nuclear Information System (INIS)

    Dunne, D.P.

    2000-01-01

    The field of shape memory phenomena in metals and alloys has developed in a sporadic fashion from a scientific curiosity to a vigorously growing niche industry, over a period close to a full working lifetime. Memory metal research and development is replete with scientist and engineer 'true believers', who can finally feel content that their longstanding confidence in the potential of these unusual functional materials has not been misplaced. This paper reviews the current range of medical and non-medical systems and devices which are based on memory metals and attempts to predict trends in applications over the next decade. The market is dominated by Ni Ti alloys which have proved to exhibit the best and most reproducible properties for application in a wide range of medical and non-medical devices

  3. Physically Functional Materials

    DEFF Research Database (Denmark)

    2002-01-01

    of information (holographic data storage), nonlinear optics (NLO), as photoconductors, photonic band-gap materials, electrically conducting materials, electroluminescent materials, piezo-electric materials, pyroelectric materials, magnetic materials, ferromagnetic materials, ferroelectric materials...... acids or peptides having azobenzenes or other physicially functional groups, e.g., photoresponsive groups, as side chains. These compounds may be synthesized using solid phase peptide synthesis techniques. Materials, e.g., thin films, comprising such compounds may be used for optical storage......, photorefractive materials, or materials in which light-induced conformational changes can be produced. Optical anisotropy may reversibly be generated with polarized laser light whereby a hologram is formed. First order diffraction efficiencies of up to around 80% have been obtained....

  4. Nostalgia: content, triggers, functions.

    Science.gov (United States)

    Wildschut, Tim; Sedikides, Constantine; Arndt, Jamie; Routledge, Clay

    2006-11-01

    Seven methodologically diverse studies addressed 3 fundamental questions about nostalgia. Studies 1 and 2 examined the content of nostalgic experiences. Descriptions of nostalgic experiences typically featured the self as a protagonist in interactions with close others (e.g., friends) or in momentous events (e.g., weddings). Also, the descriptions contained more expressions of positive than negative affect and often depicted the redemption of negative life scenes by subsequent triumphs. Studies 3 and 4 examined triggers of nostalgia and revealed that nostalgia occurs in response to negative mood and the discrete affective state of loneliness. Studies 5, 6, and 7 investigated the functional utility of nostalgia and established that nostalgia bolsters social bonds, increases positive self-regard, and generates positive affect. These findings demarcate key landmarks in the hitherto uncharted research domain of nostalgia.

  5. Spices as functional foods.

    Science.gov (United States)

    Viuda-Martos, M; Ruiz-Navajas, Y; Fernández-López, J; Pérez-Alvarez, J A

    2011-01-01

    Spices and aromatic herbs have been used since antiquity as preservatives, colorants, and flavor enhancers. Spices, which have long been the basis of traditional medicine in many countries, have also been the subject of study, particularly by the chemical, pharmaceutical, and food industries, because of their potential use for improving health. Both in vitro and in vivo studies have demonstrated how these substances act as antioxidants, digestive stimulants, and hypolipidemics and show antibacterial, anti-inflammatory, antiviral, and anticancerigenic activities. These beneficial physiological effects may also have possible preventative applications in a variety of pathologies. The aim of this review is to present an overview of the potential of spices and aromatic herbs as functional foods.

  6. Functional bowel disease

    DEFF Research Database (Denmark)

    Rumessen, J J; Gudmand-Høyer, E

    1988-01-01

    Twenty-five patients with functional bowel disease were given fructose, sorbitol, fructose-sorbitol mixtures, and sucrose. The occurrence of malabsorption was evaluated by means of hydrogen breath tests and the gastrointestinal symptoms, if any, were recorded. One patient could not be evaluated...... of fructose caused marked abdominal distress in patients with demonstrable malabsorption. Ingestion of sucrose in these patients gave less pronounced symptoms of abdominal distress. Malabsorption of a 5-g dose of sorbitol could be detected in 8 of 13 patients. Mixtures of 25 g of fructose and 5 g of sorbitol...... caused significantly increased abdominal distress, and more than additive malabsorption was found in several cases. The present study shows that pronounced gastrointestinal distress may be provoked by malabsorption of small amounts of fructose, sorbitol, and fructose-sorbitol mixtures in patients...

  7. Indicators and their functions

    DEFF Research Database (Denmark)

    Gudmundsson, Henrik; Joumard, Robert; Aschemann, Ralf

    2010-01-01

    This report is the final report of the action COST 356 'EST - Towards the definition of a measurable environmentally sustainable transport'. It tries to answer the following questions: How can environmental impacts of transport be measured? How can measurements be transformed into operational...... indicators? How can several indicators be jointly considered? And how can indicators be used in planning and decision making? Firstly we provide definition of 'indicator of environmental sustainability in transport'. The functions, strengths and weaknesses of indicators as measurement tools, and as decision...... support tools are discussed. We define what "environmental sustainability in transport" may mean through the transport system, the concepts of sustainable development and of environment. The concept of 'chain of causality' between a source and a final target is developed, as a common reference...

  8. Function valued metric spaces

    Directory of Open Access Journals (Sweden)

    Madjid Mirzavaziri

    2010-11-01

    Full Text Available In this paper we introduce the notion of an ℱ-metric, as a function valued distance mapping, on a set X and we investigate the theory of ℱ-metrics paces. We show that every metric space may be viewed as an F-metric space and every ℱ-metric space (X,δ can be regarded as a topological space (X,τδ. In addition, we prove that the category of the so-called extended F-metric spaces properly contains the category of metric spaces. We also introduce the concept of an `ℱ-metric space as a completion of an ℱ-metric space and, as an application to topology, we prove that each normal topological space is `ℱ-metrizable.

  9. Cost function estimation

    DEFF Research Database (Denmark)

    Andersen, C K; Andersen, K; Kragh-Sørensen, P

    2000-01-01

    , marital status and presence of any co-morbidity other than dementia. Models with a log-transformed dependent variable, where predicted health care costs were re-transformed to the unlogged original scale by multiplying the exponential of the expected response on the log-scale with the average...... a regression model based on the quality of its predictions. In exploring the econometric issues, the objective of this study was to estimate a cost function in order to estimate the annual health care cost of dementia. Using different models, health care costs were regressed on the degree of dementia, sex, age...... of the exponentiated residuals, were part of the considered models. The root mean square error (RMSE), the mean absolute error (MAE) and the Theil U-statistic criteria were used to assess which model best predicted the health care cost. Large values on each criterion indicate that the model performs poorly. Based...

  10. Integration a functional approach

    CERN Document Server

    Bichteler, Klaus

    1998-01-01

    This book covers Lebesgue integration and its generalizations from Daniell's point of view, modified by the use of seminorms. Integrating functions rather than measuring sets is posited as the main purpose of measure theory. From this point of view Lebesgue's integral can be had as a rather straightforward, even simplistic, extension of Riemann's integral; and its aims, definitions, and procedures can be motivated at an elementary level. The notion of measurability, for example, is suggested by Littlewood's observations rather than being conveyed authoritatively through definitions of (sigma)-algebras and good-cut-conditions, the latter of which are hard to justify and thus appear mysterious, even nettlesome, to the beginner. The approach taken provides the additional benefit of cutting the labor in half. The use of seminorms, ubiquitous in modern analysis, speeds things up even further. The book is intended for the reader who has some experience with proofs, a beginning graduate student for example. It might...

  11. NRC operation center's function

    International Nuclear Information System (INIS)

    Weiss, E.W.

    1987-01-01

    The Nuclear Regulatory Commission has maintained a 24-hour-a-day, 365 days-a-year, manned Operations Center since the emergency incident at the Three Mile Island Nuclear Power Plant in 1979. The Center functions as the NRC's point of direct communication through dedicated telephone lines for reports of significant events at licensed nuclear power plants and certain fuel cycle facilities. The Center has become a key element in the agency's emergency preparedness. The effectiveness of the NRC Operations Center depends in large measure on complete and accurate reports from the licensees. The information provided is used to: identify generic safety issues and precursor events that may compromise plant safety; develop licensee performance trends that are used to adjust NRC regulatory emphasis; and, evaluate and provide for the appropriate NRC response to events in a real time mode

  12. Baryons with functional methods

    International Nuclear Information System (INIS)

    Fischer, Christian S.

    2017-01-01

    We summarise recent results on the spectrum of ground-state and excited baryons and their form factors in the framework of functional methods. As an improvement upon similar approaches we explicitly take into account the underlying momentum-dependent dynamics of the quark-gluon interaction that leads to dynamical chiral symmetry breaking. For light octet and decuplet baryons we find a spectrum in very good agreement with experiment, including the level ordering between the positive- and negative-parity nucleon states. Comparing the three-body framework with the quark-diquark approximation, we do not find significant differences in the spectrum for those states that have been calculated in both frameworks. This situation is different in the electromagnetic form factor of the Δ, which may serve to distinguish both pictures by comparison with experiment and lattice QCD.

  13. Exercise and functional foods

    Directory of Open Access Journals (Sweden)

    Naito Yuji

    2006-06-01

    Full Text Available Abstract Appropriate nutrition is an essential prerequisite for effective improvement of athletic performance, conditioning, recovery from fatigue after exercise, and avoidance of injury. Nutritional supplements containing carbohydrates, proteins, vitamins, and minerals have been widely used in various sporting fields to provide a boost to the recommended daily allowance. In addition, several natural food components have been found to show physiological effects, and some of them are considered to be useful for promoting exercise performance or for prevention of injury. However, these foods should only be used when there is clear scientific evidence and with understanding of the physiological changes caused by exercise. This article describes various "functional foods" that have been reported to be effective for improving exercise performance or health promotion, along with the relevant physiological changes that occur during exercise.

  14. [Functional endoscopic sinus surgery].

    Science.gov (United States)

    Han, D M

    1992-01-01

    Eighty-two cases of functional endoscopic sinus surgery were analyzed. It include 62 males and 20 females; the oldest was 72 years of age and the youngest eight years of age. A hard endoscope with a diameter of 4mm and the CCD micro-videorecorder produced by Circon and Olympus Company were used. Operations were done under general anesthesia in all cases. Twenty-three cases (28.1%) recovered in one stage and recovery was delayed in 28 cases (34.2%); late inflammation occurred in 23 cases (28.1%); 8 cases failed (9.8%). The cure rate was 62.2%. Two cases (2.4%) had operative complications namely injury to the lamina papyracea and anterior ethmoidal artery, all recovered uneventfully.

  15. Lyapunov functionals and stability of stochastic functional differential equations

    CERN Document Server

    Shaikhet, Leonid

    2013-01-01

    Stability conditions for functional differential equations can be obtained using Lyapunov functionals. Lyapunov Functionals and Stability of Stochastic Functional Differential Equations describes the general method of construction of Lyapunov functionals to investigate the stability of differential equations with delays. This work continues and complements the author’s previous book Lyapunov Functionals and Stability of Stochastic Difference Equations, where this method is described for discrete- and continuous-time difference equations. The text begins with a description of the peculiarities of deterministic and stochastic functional differential equations. There follow basic definitions for stability theory of stochastic hereditary systems, and a formal procedure of Lyapunov functionals construction is presented. Stability investigation is conducted for stochastic linear and nonlinear differential equations with constant and distributed delays. The proposed method is used for stability investigation of di...

  16. Functional ionic liquids

    International Nuclear Information System (INIS)

    Baecker, Tobias

    2012-01-01

    In the thesis at hand, new functional ionic liquids were investigated. Main focus was attended to their structure property relations and the structural features leading to a decrease of the melting point. New compounds of the type 1-butyl-3-methylimidazolium tris(N,Ndialkyldithiocarbamato) uranylate with variously substituated dithiocarbamato ligands were synthesized and characterized. Ligands with asymmetrical substitution pattern proved to be most suitable for ionic liquid formation. The single-crystal X-ray structures revealed the interactions in the solid state. Here, the first spectroscopic investigation of the U-S bond in sulfur donated uranyl complexes, up to now only observed in single-crystal X-ray structures, is presented, and the participation of the uranium f-orbitals is shown by theoretical calculations. Electrochemical investigations showed the accessibility of the respective U V O 2 + compounds. As well, ionic liquids with [FeCl 4 ] - and [Cl 3 FeOFeCl 3 ] 2- as anion were synthesized. Both of these anions contain high-spin Fe(III) centres in distorted tetrahedral environment, but exhibit different magnetic behaviour. The tetrachloroferrates show the usual paramagnetism, the m-oxobis(trichloroferrate) exhibits unexpectedly strong antiferromagnetic coupling, as was observed by NMR experiments and susceptibility measurements. To investigate structure-property relations in functionalized ionic liquids, a set of protic, primary alkylammonium and aprotic, quarternary trimethylalkylammonium based ionic liquids was synthesized, and characterized. The length of the alkyl chain was systematically varied, and all compounds were synthesized with and without hydroxyl group, as well as formate and bis(triflyl)amide salts, aiming at getting insight into the influence of the different structure parts on the respective ionic liquid's properties.

  17. Tamoxifen and ovarian function.

    Directory of Open Access Journals (Sweden)

    Martine Berliere

    Full Text Available BACKGROUND: Some studies suggest that the clinical parameter "amenorrhea" is insufficient to define the menopausal status of women treated with chemotherapy or tamoxifen. In this study, we investigated and compared the ovarian function defined either by clinical or biological parameters in pre-menopausal breast cancer patients treated with tamoxifen administered as adjuvant therapy. MATERIALS AND METHODS: Between 1999 and 2003, 138 premenopausal patients consecutively treated for early breast cancer were included. Sixty-eight received tamoxifen in monotherapy as the only adjuvant systemic treatment (Group I and 70 were treated with tamoxifen after adjuvant chemotherapy (Group II. All patients had a confirmed premenopausal status based on clinical parameters and hormonal values at study entry. They were followed prospectively every 3 months for 3 years: menses data, physical examination and blood tests (LH, FSH, 17-beta-estradiol. Vaginal ultrasonography was carried out every 6 months. After 3 years, prospective evaluation was completed and monitoring of ovarian function was performed as usual in our institution (1x/year. All data were retrospectively evaluated in 2011. RESULTS: Three patients were excluded from the study in group I and 2 were excluded in group II. Patients were divided into 4 subgroups according to clinical data, i.e. menses patterns. These patterns were assessed by questionnaires. a: Regular menses (>10 cycles/year b: Oligomenorrhea (5 to 9 cycles/year c: Severe oligomenorrhea (1 to 4 cycles/year d: Complete amenorrhea Estrogen levels did not appear to have any impact on disease-free survival rates after 3 or 8 years. FSH values were also documented and analyzed. They exhibited the same profile as estradiol values. CONCLUSIONS: Amenorrhea is an insufficient parameter to define menopausal status in patients receiving tamoxifen. Low estradiol levels must be coupled with other biological parameters to characterize endocrine status

  18. Construction of global Lyapunov functions using radial basis functions

    CERN Document Server

    Giesl, Peter

    2007-01-01

    The basin of attraction of an equilibrium of an ordinary differential equation can be determined using a Lyapunov function. A new method to construct such a Lyapunov function using radial basis functions is presented in this volume intended for researchers and advanced students from both dynamical systems and radial basis functions. Besides an introduction to both areas and a detailed description of the method, it contains error estimates and many examples.

  19. Sinc-function based Network

    DEFF Research Database (Denmark)

    Madsen, Per Printz

    1999-01-01

    The purpose of this paper is to describe a neural network (SNN), that is based on Shannons ideas of reconstruction of a real continuous function from its samples. The basic function, used in this network, is the Sinc-function. Two learning algorithms are described. A simple one called IM-learning......The purpose of this paper is to describe a neural network (SNN), that is based on Shannons ideas of reconstruction of a real continuous function from its samples. The basic function, used in this network, is the Sinc-function. Two learning algorithms are described. A simple one called IM...

  20. Extended asymptotic functions - some examples

    International Nuclear Information System (INIS)

    Todorov, T.D.

    1981-01-01

    Several examples of extended asymptotic functions of two variables are given. This type of asymptotic functions has been introduced as an extension of continuous ordinary functions. The presented examples are realizations of some Schwartz distributions delta(x), THETA(x), P(1/xsup(n)) and can be multiplied in the class of the asymptotic functions as opposed to the theory of Schwartz distributions. The examples illustrate the method of construction of extended asymptotic functions similar to the distributions. The set formed by the extended asymptotic functions is also considered. It is shown, that this set is not closed with respect to addition and multiplication

  1. Symmetric q-Bessel functions

    Directory of Open Access Journals (Sweden)

    Giuseppe Dattoli

    1996-05-01

    Full Text Available q analog of bessel functions, symmetric under the interchange of q and q^ −1 are introduced. The definition is based on the generating function realized as product of symmetric q-exponential functions with appropriate arguments. Symmetric q-Bessel function are shown to satisfy various identities as well as second-order q-differential equations, which in the limit q → 1 reproduce those obeyed by the usual cylindrical Bessel functions. A brief discussion on the possible algebraic setting for symmetric q-Bessel functions is also provided.

  2. Methylmercury toxicity and functional programming

    DEFF Research Database (Denmark)

    Grandjean, Philippe

    2007-01-01

    PURPOSE: Adverse health effects of developmental toxicants may induce abnormal functional programming that leads to lasting functional deficits. This notion is considered from epidemiological evidence using developmental methylmercury neurotoxicity as an example. MOST IMPORTANT FINDINGS...... by neurodevelopmental methylmercury toxicity fit into the pattern of functional programming, with effects opposite to those linked to beneficial stimuli....... of certain brain functions, thereby causing confounding bias. The functional deficits caused by prenatal methylmercury exposure appear to be permanent, and their extent may depend on the joint effect of toxicants and nutrients. PRINCIPAL CONCLUSIONS: The lasting functional changes caused...

  3. Variational energy functionals of the Green function tested on molecules

    NARCIS (Netherlands)

    Dahlen, NE; Von Barth, U; Dahlen, Nils Erik

    2005-01-01

    It was recently proposed to use variational functionals based on manybody perturbation theory for the calculation of the total energies of many-electron systems. The accuracy of such functionals depends on the degree of sophistication of the underlying perturbation expansions. The energy functionals

  4. Properties of field functionals and characterization of local functionals

    Science.gov (United States)

    Brouder, Christian; Dang, Nguyen Viet; Laurent-Gengoux, Camille; Rejzner, Kasia

    2018-02-01

    Functionals (i.e., functions of functions) are widely used in quantum field theory and solid-state physics. In this paper, functionals are given a rigorous mathematical framework and their main properties are described. The choice of the proper space of test functions (smooth functions) and of the relevant concept of differential (Bastiani differential) are discussed. The relation between the multiple derivatives of a functional and the corresponding distributions is described in detail. It is proved that, in a neighborhood of every test function, the support of a smooth functional is uniformly compactly supported and the order of the corresponding distribution is uniformly bounded. Relying on a recent work by Dabrowski, several spaces of functionals are furnished with a complete and nuclear topology. In view of physical applications, it is shown that most formal manipulations can be given a rigorous meaning. A new concept of local functionals is proposed and two characterizations of them are given: the first one uses the additivity (or Hammerstein) property, the second one is a variant of Peetre's theorem. Finally, the first step of a cohomological approach to quantum field theory is carried out by proving a global Poincaré lemma and defining multi-vector fields and graded functionals within our framework.

  5. Current density functional theory for optical spectra : A polarization functional

    NARCIS (Netherlands)

    Boeij, P.L. de; Kootstra, F.; Berger, J.A.; Leeuwen, R. van; Snijders, J.G.

    2001-01-01

    In this paper we present a new approach to calculate optical spectra, which for the first time uses a polarization dependent functional within current density functional theory (CDFT), which was proposed by Vignale and Kohn. This polarization dependent functional includes exchange-correlation (xc)

  6. New Bilateral Type Generating Function Associated with I-Function

    Directory of Open Access Journals (Sweden)

    Praveen Agarwal

    2014-01-01

    Full Text Available We aim at establishing a new bilateral type generating function associated with the I-function and a Mellin-Barnes type of contour integral. The results derived here are of general character and can yield a number of (known and new results in the theory of generating functions.

  7. Parallel transaction processing in functional languages, towards practical functional databases

    NARCIS (Netherlands)

    Wevers, L.; Huisman, Marieke; de Keijzer, Ander

    2013-01-01

    This paper shows how functional languages can be adapted for transaction processing, and discusses the implementation of a parallel runtime system for such functional transaction processing languages. We extend functional languages with current state variables and result state variables to allow the

  8. On functions of bounded semivariation

    Czech Academy of Sciences Publication Activity Database

    Monteiro, Giselle Antunes

    2015-01-01

    Roč. 40, č. 2 (2015), s. 233-276 ISSN 0147-1937 Institutional support: RVO:67985840 Keywords : semivariation * functions of bounded variation * regulated functions Subject RIV: BA - General Mathematics http://projecteuclid.org/euclid. rae /1491271216

  9. Antiderivative Series for Differentiable Functions

    Science.gov (United States)

    Howard, Roy M.

    2004-01-01

    A series defining the antiderivative of an n th order differentiable function is defined. This series provides an explicit expression for the second part of the Fundamental Theorem of Calculus and can facilitate the establishment of new antiderivative functions.

  10. Functional programming for computer vision

    Science.gov (United States)

    Breuel, Thomas M.

    1992-04-01

    Functional programming is a style of programming that avoids the use of side effects (like assignment) and uses functions as first class data objects. Compared with imperative programs, functional programs can be parallelized better, and provide better encapsulation, type checking, and abstractions. This is important for building and integrating large vision software systems. In the past, efficiency has been an obstacle to the application of functional programming techniques in computationally intensive areas such as computer vision. We discuss and evaluate several 'functional' data structures for representing efficiently data structures and objects common in computer vision. In particular, we will address: automatic storage allocation and reclamation issues; abstraction of control structures; efficient sequential update of large data structures; representing images as functions; and object-oriented programming. Our experience suggests that functional techniques are feasible for high- performance vision systems, and that a functional approach simplifies the implementation and integration of vision systems greatly. Examples in C++ and SML are given.

  11. Cognition and brain functional aging

    Directory of Open Access Journals (Sweden)

    Hui-jie LI

    2014-03-01

    Full Text Available China has the largest population of elderly adults. Meanwhile, it is one of the countries showing fastest aging speed in the world. Aging processing is always companied with a series of brain structural and functional changes, which result in the decline of processing speed, working memory, long-term memory and executive function, etc. The studies based on functional magnetic resonance imaging (fMRI found certain aging effects on brain function activation, spontaneous activity and functional connectivity in old people. However, few studies have explored the brain functional curve during the aging process while most previous studies explored the differences in the brain function between young people and old people. Delineation of the human brain functional aging curve will promote the understanding of brain aging mechanisms and support the normal aging monitoring and early detection of abnormal aging changes. doi: 10.3969/j.issn.1672-6731.2014.03.005

  12. Functionalized silica materials for electrocatalysis

    Indian Academy of Sciences (India)

    air batteries, fuel cells, electrochemical sensors, etc. To increase the efficiency of the electrocatalytic process and to increase the electrochemical accessibility of the immobilized electrocatalysts, functionalized and non-functionalized meso-.

  13. Coefficient regions for schlicht functions

    CERN Document Server

    Schaeffer, A C

    2013-01-01

    Instead of investigating various isolated extremal problems in the theory of schlicht functions, the authors have concentrated their efforts on the investigation of the family of extremal schlicht functions in the large.

  14. Lung function; Lungenfunktion

    Energy Technology Data Exchange (ETDEWEB)

    Sorichter, S. [Universitaetsklinikum Freiburg, Abteilung Pneumologie, Freiburg (Germany)

    2009-08-15

    The term lung function is often restricted to the assessment of volume time curves measured at the mouth. Spirometry includes the assessment of lung volumes which can be mobilised with the corresponding flow-volume curves. In addition, lung volumes that can not be mobilised, such as the residual volume, or only partially as FRC and TLC can be measured by body plethysmography combined with the determination of the airway resistance. Body plethysmography allows the correct positioning of forced breathing manoeuvres on the volume-axis, e.g. before and after pharmacotherapy. Adding the CO single breath transfer factor (T{sub LCO}), which includes the measurement of the ventilated lung volume using He, enables a clear diagnosis of different obstructive, restrictive or mixed ventilatory defects with and without trapped air. Tests of reversibility and provocation, as well as the assessment of inspiratory mouth pressures (PI{sub max}, P{sub 0.1}) help to classify the underlying disorder and to clarify treatment strategies. For further information and to complete the diagnostic of disturbances of the ventilation, diffusion and/or perfusion (capillar-)arterial bloodgases at rest and under physical strain sometimes amended by ergospirometry are recommended. Ideally, lung function measurements are amended by radiological and nuclear medicine techniques. (orig.) [German] Unter dem Begriff Lungenfunktion wird die Bestimmung der Lungenvolumina am Mund verstanden. Dabei werden die mobilisierbaren Lungenvolumina mit den zugehoerigen Fluss-Volumen-Kurven mittels Spirometrie und Ganzkoerperplethysmographie (GKP) und die nicht (RV) und teilweise mobilisierbaren Lungenvolumina (FRC, TLC) einschliesslich der Atemwegswiderstaende bestimmt. Die GKP ermoeglicht zusaetzlich die korrekte (Volumenachsen-)Positionierung der forcierten Atemmanoever. Dieses erlaubt eine uebersichtlichere graphische Darstellung z. B. vor und nach der Applikation pharmakologisch wirksamer Substanzen. Wird die GKP

  15. Functional equations for Feynman integrals

    International Nuclear Information System (INIS)

    Tarasov, O.V.

    2011-01-01

    New types of equations for Feynman integrals are found. It is shown that Feynman integrals satisfy functional equations connecting integrals with different kinematics. A regular method is proposed for obtaining such relations. The derivation of functional equations for one-loop two-, three- and four-point functions with arbitrary masses and external momenta is given. It is demonstrated that functional equations can be used for the analytic continuation of Feynman integrals to different kinematic domains

  16. Algorithm for programming function generators

    International Nuclear Information System (INIS)

    Bozoki, E.

    1981-01-01

    The present paper deals with a mathematical problem, encountered when driving a fully programmable μ-processor controlled function generator. An algorithm is presented to approximate a desired function by a set of straight segments in such a way that additional restrictions (hardware imposed) are also satisfied. A computer program which incorporates this algorithm and automatically generates the necessary input for the function generator for a broad class of desired functions is also described

  17. Sub-Rayleigh ghost imaging via sparsity constraints based on a digital micro-mirror device

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Jie; Gong, Wenlin, E-mail: gongwl@siom.ac.cn; Han, Shensheng, E-mail: sshan@mail.shcnc.ac.cn

    2013-10-30

    In a diffraction-limited system, the imaging resolution limit is given by Rayleigh criterion. When both the image's sparsity and the point spread function determined by the optical system's Rayleigh diffraction limit are taken as popular a priori, sub-Rayleigh ghost imaging, which is backed up by numerical simulation and experiments, is achieved by modulating the thermal light with a digital micro-mirror device (DMD). The differences between this approach and former ghost imaging without considering the optical system's point spread function are also discussed.

  18. Microbial Functional Gene Diversity Predicts Groundwater Contamination and Ecosystem Functioning

    Science.gov (United States)

    Zhang, Ping; Wu, Linwei; Rocha, Andrea M.; Shi, Zhou; Wu, Bo; Qin, Yujia; Wang, Jianjun; Yan, Qingyun; Curtis, Daniel; Ning, Daliang; Van Nostrand, Joy D.; Wu, Liyou; Watson, David B.; Adams, Michael W. W.; Alm, Eric J.; Adams, Paul D.; Arkin, Adam P.

    2018-01-01

    ABSTRACT Contamination from anthropogenic activities has significantly impacted Earth’s biosphere. However, knowledge about how environmental contamination affects the biodiversity of groundwater microbiomes and ecosystem functioning remains very limited. Here, we used a comprehensive functional gene array to analyze groundwater microbiomes from 69 wells at the Oak Ridge Field Research Center (Oak Ridge, TN), representing a wide pH range and uranium, nitrate, and other contaminants. We hypothesized that the functional diversity of groundwater microbiomes would decrease as environmental contamination (e.g., uranium or nitrate) increased or at low or high pH, while some specific populations capable of utilizing or resistant to those contaminants would increase, and thus, such key microbial functional genes and/or populations could be used to predict groundwater contamination and ecosystem functioning. Our results indicated that functional richness/diversity decreased as uranium (but not nitrate) increased in groundwater. In addition, about 5.9% of specific key functional populations targeted by a comprehensive functional gene array (GeoChip 5) increased significantly (P contamination and ecosystem functioning. This study indicates great potential for using microbial functional genes to predict environmental contamination and ecosystem functioning. PMID:29463661

  19. Function Point Analysis Depot

    Science.gov (United States)

    Muniz, R.; Martinez, El; Szafran, J.; Dalton, A.

    2011-01-01

    The Function Point Analysis (FPA) Depot is a web application originally designed by one of the NE-C3 branch's engineers, Jamie Szafran, and created specifically for the Software Development team of the Launch Control Systems (LCS) project. The application consists of evaluating the work of each developer to be able to get a real estimate of the hours that is going to be assigned to a specific task of development. The Architect Team had made design change requests for the depot to change the schema of the application's information; that information, changed in the database, needed to be changed in the graphical user interface (GUI) (written in Ruby on Rails (RoR and the web service/server side in Java to match the database changes. These changes were made by two interns from NE-C, Ricardo Muniz from NE-C3, who made all the schema changes for the GUI in RoR and Edwin Martinez, from NE-C2, who made all the changes in the Java side.

  20. Functionalized Carbon Nanotubes

    Science.gov (United States)

    Lebron, Marisabel; Mintz, Eric; Meador, Michael A.; Hull, David R.; Scheiman, Daniel A.; Willis, Peter; Smalley, Richard E.

    2001-01-01

    Carbon nanotubes have created a great deal of excitement in the Materials Science community because of their outstanding mechanical, electrical, and thermal properties. Use of carbon nanotubes as reinforcements for polymers could lead to a new class of composite materials with properties, durability, and performance far exceeding that of conventional fiber reinforced composites. Organized arrays of carbon nanotubes, e.g., nanotube monolayers, could find applications as thermal management materials, light emitting devices, and sensor arrays. Carbon nanotubes could also be used as templates upon which nanotubes from other materials could be constructed. Successful use of carbon nanotubes in any of these potential applications requires the ability to control the interactions of nanotubes with each other and with other materials, e.g., a polymer matrix. One approach to achieving this control is to attach certain chemical groups to the ends and/or side-walls of the nanotubes. The nature of these chemical groups can be varied to achieve the desired result, such as better adhesion between the nanotubes and a polymer. Under a joint program between NASA Glenn, Clark Atlanta University, and Rice University researchers are working on developing a chemistry "tool-kit" that will enable the functionalization of carbon nanotubes with a variety of chemical groups. Recent results of this effort will be discussed.

  1. Functional neuroanatomy of tics.

    Science.gov (United States)

    Neuner, Irene; Schneider, Frank; Shah, N Jon

    2013-01-01

    The therapeutic success of haloperidol in the treatment of Tourette syndrome (TS) put an end to the discussion about a "hysteric" or "neurotic" origin of TS. The cortico-striato-thalamo-cortical circuit has been identified as an underlying neurobiological correlate of TS. In this review we explore the main findings of structural alterations in TS including cortical areas, basal ganglia, hippocampus, amygdala, midbrain, and cerebellum. Based on the structural changes we examine the functional pattern described by the findings of fMRI and (15)O-PET/(18)FDG PET investigations. From the neuroimaging findings a cortical origin of the generation of tics is indicated. Future research on the neuronal footprint of TS should be directed towards addressing the question of which patterns of connectivity distinguish individuals in whom tics disappear during early adulthood from those in whom the tics persist. The understanding of this pathomechanism could provide a key on how to influence dysconnectivity in TS, for example, by more specific pharmaceutical intervention or by individually adopted EEG and/or fMRI neurofeedback. © 2013 Elsevier Inc. All rights reserved.

  2. Seafood as functional food

    Directory of Open Access Journals (Sweden)

    Marcilene C. Heidmann Soccol

    2003-06-01

    Full Text Available Functional food presents specific physiological properties, supplies nutrients and can be naturally found in formulated food or added to it. Seafood plays an important role in human diet, representing the largest stock available of w-3 polyunsaturated fatty acids, especially eicosapentaenoic (EPA and docosahexaenoic (DHA. Scientific researchers have intensified their studies on fatty acids due to their importance in preventing and/or curing diseases, especially cardiovascular and inflammatory ones. This review describes the most important aspects of w-3 fatty acids found in fish, as well as their roles in the mechanism involved in the prevention and control of diseases.O pescado é um importante constituinte da dieta humana e possui a maior reserva de ácidos graxos polinsaturados, especialmente o eicosapentanóico (EPA e o docosahexanóico (DHA da série w-3. Têm-se intensificado as pesquisas científicas a respeito desses ácidos graxos por estes estarem envolvidos na prevenção e/ou cura de doenças, principalmente cardiovasculares e inflamatórias. Esta revisão teve como objetivo discutir os aspectos mais importantes dos ácidos graxos w-3 presentes no pescado, bem como, os seus mecanismos de ação, envolvidos na prevenção e controle de doenças.

  3. Recycling retention functions

    International Nuclear Information System (INIS)

    Skrable, K.W.; Chabot, G.E.; Johnson, M.H.

    1981-01-01

    Beginning with the concept of any number of physiologically meaningful compartments that recycle material with a central extracellular fluid compartment and considering various excretion pathways, we solve the differential equations describing the kinetics by the method of Laplace to obtain concise algebraic expressions for the retentions. These expressions contain both fundamental and eigenvalue rate constants; the eigenvalue rate constants are obtained from the solution of a polynomial incorporating the fundamental rate constants. Mathematically exact expressions that predict the biodistribution resulting from continuous uptakes are used to obtain very simple mathematically exact steady state expressions as well as approximate expressions applicable to any time. These steady state and approximate expressions contain only the fundamental rate constants; also, they include a recycling factor that describes the increase in the biodistributions because of recycling. To obtain the values of the fundamental rate constants, short term kinetics studies along with data on the long term distributions are suggested. Retention functions obtained in this way predict both the short term and long term distributions; they therefore are useful in the interpretation of bioassay data and in the estimation of internal doses

  4. Fuzzy SP-irresolute functions

    International Nuclear Information System (INIS)

    Abbas, S.E.

    2004-01-01

    In this paper, fuzzy SP-irresolute, fuzzy SP-irresolute open and fuzzy SP-irresolute closed functions between fuzzy topological spaces in Sostak sense are defined. Their properties and the relationships between these functions and other functions introduced previously are investigated. Next fuzzy SP-connectedness is introduced and studied with the help of r-fuzzy strongly preopen sets

  5. Structure function measurements from HERA

    Indian Academy of Sciences (India)

    Structure function measurements from HERA. A MEHTA. Department of Physics, Oliver Lodge Laboratory, Liverpool University, Liverpool, L69 7ZR, UK. Abstract. In this paper recent measurements of structure functions from the HERA Collaborations are presented. Keywords. Structure functions; HERA; F2; F3; FL. PACS No.

  6. Family Functioning in Pediatric Trichotillomania

    Science.gov (United States)

    Moore, Phoebe S.; Franklin, Martin E.; Keuthen, Nancy J.; Flessner, Christopher A.; Woods, Douglas W.; Piacentini, John A.; Stein, Dan J.; Loew, Benjamin

    2009-01-01

    Little is known about how pediatric trichotillomania (TTM), a clinically significant and functionally impairing disorder, is impacted by, and impacts, family functioning. We explored dimensions of family functioning and parental attitudes in a sample of children and adolescents who participated in an Internet-based survey and satisfied…

  7. Education Function of Botanical Gardens

    OpenAIRE

    Ruhugül Özge Ocak; Banu Öztürk Kurtaslan

    2015-01-01

    Botanical gardens are very significant organizations which protect the environment against the increasing environmental problems, provide environmental education for people, offer recreation possibilities, etc. This article describes botanical gardens and their functions. The most important function of botanical garden is to provide environmental education for people and improve environmental awareness. Considering this function, some botanical gardens were examined and o...

  8. What is a Sorting Function?

    DEFF Research Database (Denmark)

    Henglein, Fritz

    2009-01-01

    What is a sorting function—not a sorting function for a given ordering relation, but a sorting function with nothing given? Formulating four basic properties of sorting algorithms as defining requirements, we arrive at intrinsic notions of sorting and stable sorting: A function is a sorting funct...... are derivable without compromising data abstraction. Finally we point out that stable sorting functions as default representations of ordering relations have the advantage of permitting linear-time sorting algorithms; inequality tests forfeit this possibility.......What is a sorting function—not a sorting function for a given ordering relation, but a sorting function with nothing given? Formulating four basic properties of sorting algorithms as defining requirements, we arrive at intrinsic notions of sorting and stable sorting: A function is a sorting...... function if and only it is an intrinsically parametric permutation function. It is a stable sorting function if and only if it is an intrinsically stable permutation function. We show that ordering relations can be represented isomorphically as inequality tests, comparators and stable sorting functions...

  9. Divisors, measures and critical functions

    Indian Academy of Sciences (India)

    obtained by Popescu et al [5]. Keywords. Trace function; divisors; minimal polynomial; critical function. .... In §5 we define the critical function associated to divisors with compact support. We show in Theorem 5.5 that ...... Remark 5.6. Based on Remark 4.4 one might think that Theorem 5.5 is weaker than. Theorem 1.11 in [5].

  10. Disgust: Evolved function and structure

    NARCIS (Netherlands)

    Tybur, J.M.; Lieberman, D.; Kurzban, R.; DeScioli, P.

    2013-01-01

    Interest in and research on disgust has surged over the past few decades. The field, however, still lacks a coherent theoretical framework for understanding the evolved function or functions of disgust. Here we present such a framework, emphasizing 2 levels of analysis: that of evolved function and

  11. Functional unit for a processor

    NARCIS (Netherlands)

    Rohani, A.; Kerkhoff, Hans G.

    2013-01-01

    The invention relates to a functional unit for a processor, such as a Very Large Instruction Word Processor. The invention further relates to a processor comprising at least one such functional unit. The invention further relates to a functional unit and processor capable of mitigating the effect of

  12. Mahlburg's Work on Crank Functions

    Indian Academy of Sciences (India)

    IAS Admin

    plaining partition congruences of Ramanujan-type and it has once again opened discussions on congruence mod- ulo functions by Ramanujan. Mahlburg's theory not only gave general ideas on crank functions but showed a novel way to generate them through crank generating functions. He proved Ken Ono's conjecture ...

  13. about the Dirac Delta Function(?)

    Indian Academy of Sciences (India)

    we enter "delta function" in quotes. This produces a less stupendous 58,600 references. As even this is too much, we try Dirac delta function, to get ... this down to 872, while "the delta function of Dirac" yields a comfortable (but not uniformly helpful) 19 ref- erences. Motivated by a desire to include some interesting histor-.

  14. A lung function information system

    NARCIS (Netherlands)

    A.F.M. Verbraak (Anton); E.J. Hoorn (Ewout); J. de Vries (Julius); J.M. Bogaard (Jan); A. Versprille (Adrian)

    1991-01-01

    markdownabstractAbstract A lung function information system (LFIS) was developed for the data analysis of pulmonary function tests at different locations. This system was connected to the hospital information system (HIS) for the retrieval of patient data and the storage of the lung function

  15. Generalized Boolean Functions as Combiners

    Science.gov (United States)

    2017-06-01

    backbone of many computer functions. Cryptography drives online commerce and allows privileged information safe transit between two parties as well as many...the backbone of many computer functions. Cryptography drives online commerce and allows privileged information safe transit be- tween two parties as...Functions 5 2.1 Linear Feedback Shift Registers . . . . . . . . . . . . . . . . . . 5 2.2 Combiners . . . . . . . . . . . . . . . . . . . . . . . . . . . 8

  16. Extended screened exchange functional derived from transcorrelated density functional theory.

    Science.gov (United States)

    Umezawa, Naoto

    2017-09-14

    We propose a new formulation of the correlation energy functional derived from the transcorrelated method in use in density functional theory (TC-DFT). An effective Hamiltonian, H TC , is introduced by a similarity transformation of a many-body Hamiltonian, H, with respect to a complex function F: H TC =1FHF. It is proved that an expectation value of H TC for a normalized single Slater determinant, D n , corresponds to the total energy: E[n] = ⟨Ψ n |H|Ψ n ⟩/⟨Ψ n |Ψ n ⟩ = ⟨D n |H TC |D n ⟩ under the two assumptions: (1) The electron density nr associated with a trial wave function Ψ n = D n F is v-representable and (2) Ψ n and D n give rise to the same electron density nr. This formulation, therefore, provides an alternative expression of the total energy that is useful for the development of novel correlation energy functionals. By substituting a specific function for F, we successfully derived a model correlation energy functional, which resembles the functional form of the screened exchange method. The proposed functional, named the extended screened exchange (ESX) functional, is described within two-body integrals and is parametrized for a numerically exact correlation energy of the homogeneous electron gas. The ESX functional does not contain any ingredients of (semi-)local functionals and thus is totally free from self-interactions. The computational cost for solving the self-consistent-field equation is comparable to that of the Hartree-Fock method. We apply the ESX functional to electronic structure calculations for a solid silicon, H - ion, and small atoms. The results demonstrate that the TC-DFT formulation is promising for the systematic improvement of the correlation energy functional.

  17. Work function of carburized rhenium

    International Nuclear Information System (INIS)

    Pallmer, P.G. Jr.; Gordon, R.L.; Dresser, M.J.

    1980-01-01

    Variations of the electronic work function of carburized rhenium foils containing approximately 5 at.% carbon have been observed using the contact potential difference technique. Surface work function was observed to vary between 5.25 and 4.1 eV, with the work function of pure rhenium taken as 5.0 eV. Decrease in work function has been ascribed to the formation of graphitic layers on the surface at temperatures below the temperature of saturated solubility. The high work function surface was observed with all carbon in solution and has been ascribed to the presence of amorphous carbon near the surface

  18. Functional Analysis in Interdisciplinary Applications

    CERN Document Server

    Nursultanov, Erlan; Ruzhansky, Michael; Sadybekov, Makhmud

    2017-01-01

    This volume presents current research in functional analysis and its applications to a variety of problems in mathematics and mathematical physics. The book contains over forty carefully refereed contributions to the conference “Functional Analysis in Interdisciplinary Applications” (Astana, Kazakhstan, October 2017). Topics covered include the theory of functions and functional spaces; differential equations and boundary value problems; the relationship between differential equations, integral operators and spectral theory; and mathematical methods in physical sciences. Presenting a wide range of topics and results, this book will appeal to anyone working in the subject area, including researchers and students interested to learn more about different aspects and applications of functional analysis.

  19. Functional equations with causal operators

    CERN Document Server

    Corduneanu, C

    2003-01-01

    Functional equations encompass most of the equations used in applied science and engineering: ordinary differential equations, integral equations of the Volterra type, equations with delayed argument, and integro-differential equations of the Volterra type. The basic theory of functional equations includes functional differential equations with causal operators. Functional Equations with Causal Operators explains the connection between equations with causal operators and the classical types of functional equations encountered by mathematicians and engineers. It details the fundamentals of linear equations and stability theory and provides several applications and examples.

  20. Banach spaces of analytic functions

    CERN Document Server

    Hoffman, Kenneth

    2007-01-01

    A classic of pure mathematics, this advanced graduate-level text explores the intersection of functional analysis and analytic function theory. Close in spirit to abstract harmonic analysis, it is confined to Banach spaces of analytic functions in the unit disc.The author devotes the first four chapters to proofs of classical theorems on boundary values and boundary integral representations of analytic functions in the unit disc, including generalizations to Dirichlet algebras. The fifth chapter contains the factorization theory of Hp functions, a discussion of some partial extensions of the f

  1. [Functional imaging of pain].

    Science.gov (United States)

    Peyron, Roland

    2014-01-01

    In this review, we summarize the contribution of functional imaging to the question of nociception in humans. In the beginning of the 90's, brain areas supposed to be involved in physiological pain processes essentially concerned the primary somatosensory area (SI), thalamus, and anterior cingulate cortex. In spite of these a priori hypotheses, the first imaging studies revealed that the main brain areas and those providing the most consistent activations in pain conditions were the insular and the SII cortices, bilaterally. This has been checked with other techniques such as intracerebral recordings of evoked potentials after nociceptive stimulations with laser showing a consistent response in the operculo-insular area whose amplitude correlates with pain intensity. In spite of electrode implantations in other areas of the brain, only rare and inconsistent responses have been found outside the operculo-insular cortices. With electrical stimulation delivered directly in the brain, it has also been shown that stimulation in this area only - and not in other brain areas - was able to elicit a painful sensation. Thus, over the last 15 years, the operculo-insular cortex has been re-discovered as a main area of pain integration, mainly in its sensory and intensity aspects. In neuropathic pain also, these areas have been demonstrated as being abnormally recruited, bilaterally, in response to innocuous stimuli. These results suggest that plastic changes may occur in brain areas that were pre-defined for generating pain sensations. Conversely, when the brain activations concomitant to pain relief were taken in account, a large number of studies pointed out medial prefrontal and rostral cingulate areas as being associated with pain controls. Interestingly, these activations may correlate with the magnitude of pain relief, with the activation of the peri-acqueductal grey (PAG) and, at least in some instances, with the involvement of endogenous opioids. © Société de

  2. (Implications, Motivations and Functions

    Directory of Open Access Journals (Sweden)

    Mahmood Shahabi

    2015-03-01

    Full Text Available A major concern in the last few years has been the fact that the Cultural Centers are keeping distance with what they have been established for, and instead of reproducing the hegemony, they have turned into a place for resistance and reproduction of resistance against hegemony. Cultural Centers, as urban public spaces in the last two decades, have been the subject of ideological discussions and debates. In such spaces, consumption is not just limited to the utilization of programs in cultural centers, but the consumption of Cultural Center’s spaces prevail the consumption of activities and programs in these Cultural Centers. Such consumption is associated with the introduction of several social and cultural definitions. The main purpose of this study is to identify the application and implications of the Cultural Centers for the youth in Tehran and the motivations and functions resulting from the consumption of these spaces. The study uses the method of basic theorization for the data collection and analysis. For this purpose, 25 of clients in Bahman, Shafagh, Honar, Kar, Quran and Eshragh Cultural Centers located in Tehran have been the subjects of in-depth interview. Totally, the results of this study show that Cultural Centers are a part of rites of transition to the adulthood for the youth of Tehran. They satisfy many of the needs related to their age, and in one word, they draw their own painting on the canvass of this public space. The Present study is going to describe and elaborate the painting patterns and interference in and intervention with the public space of the Cultural Centers. In this study, Cultural Center is considered as a context and its several implications for the users of this space are analyzed.

  3. Functional Magnetic Nanoparticles

    Science.gov (United States)

    Gass, James

    Nanoparticle system research and characterization is the focal point of this research and dissertation. In the research presented here, magnetite, cobalt, and ferrite nanoparticle systems have been explored in regard to their magnetocaloric effect (MCE) properties, as well as for use in polymer composites. Both areas of study have potential applications across a wide variety of interdisciplinary fields. Magnetite nanoparticles have been successfully dispersed in a polymer. The surface chemistry of the magnetic nanoparticle proves critical to obtaining a homogenous and well separated high density dispersion in PMMA. Theoretical studies found in the literature have indicated that surface interface energy is a critical component in dispersion. Oleic acid is used to alter the surface of magnetite nanoparticles and successfully achieve good dispersion in a PMMA thin film. Polypyrrole is then coated onto the PMMA composite layer. The bilayer is characterized using cross-sectional TEM, cross-sectional SEM, magnetic characterization, and low frequency conductivity. The results show that the superparmagnetic properties of the as synthesized particles are maintained in the composite. With further study of the properties of these nanoparticles for real and functional uses, MCE is studied on a variety of magnetic nanoparticle systems. Magnetite, manganese zinc ferrite, and cobalt ferrite systems show significant broadening of the MCE and the ability to tune the peak temperature of MCE by varying the size of the nanoparticles. Four distinct systems are studied including cobalt, cobalt core silver shell nanoparticles, nickel ferrite, and ball milled zinc ferrite. The results demonstrate the importance of surface characteristics on MCE. Surface spin disorder appears to have a large influence on the low temperature magnetic and magnetocalorie characteristics of these nanoparticle systems.

  4. Density functional theory

    International Nuclear Information System (INIS)

    Freyss, M.

    2015-01-01

    This chapter gives an introduction to first-principles electronic structure calculations based on the density functional theory (DFT). Electronic structure calculations have a crucial importance in the multi-scale modelling scheme of materials: not only do they enable one to accurately determine physical and chemical properties of materials, they also provide data for the adjustment of parameters (or potentials) in higher-scale methods such as classical molecular dynamics, kinetic Monte Carlo, cluster dynamics, etc. Most of the properties of a solid depend on the behaviour of its electrons, and in order to model or predict them it is necessary to have an accurate method to compute the electronic structure. DFT is based on quantum theory and does not make use of any adjustable or empirical parameter: the only input data are the atomic number of the constituent atoms and some initial structural information. The complicated many-body problem of interacting electrons is replaced by an equivalent single electron problem, in which each electron is moving in an effective potential. DFT has been successfully applied to the determination of structural or dynamical properties (lattice structure, charge density, magnetisation, phonon spectra, etc.) of a wide variety of solids. Its efficiency was acknowledged by the attribution of the Nobel Prize in Chemistry in 1998 to one of its authors, Walter Kohn. A particular attention is given in this chapter to the ability of DFT to model the physical properties of nuclear materials such as actinide compounds. The specificities of the 5f electrons of actinides will be presented, i.e., their more or less high degree of localisation around the nuclei and correlations. The limitations of the DFT to treat the strong 5f correlations are one of the main issues for the DFT modelling of nuclear fuels. Various methods that exist to better treat strongly correlated materials will finally be presented. (author)

  5. Functional imaging of the pancreas

    International Nuclear Information System (INIS)

    Nakanishi, Fumiko

    1984-01-01

    An image processing technique for functional imaging of the pancreas was developed and is here reported. In this paper, clinical efficacy of the technique for detecting pancreatic abnormality is evaluated in comparison with conventional pancreatic scintigraphy and CT. For quantitative evaluation, functional rate, i.e. the rate of normal functioning pancreatic area, was calculated from the functional image and subtraction image. Two hundred and ninety-five cases were studied using this technique. Conventional image had a sensitivity of 65 % and a specificity of 78 %, while the use of functional imaging improved sensitivity to 88 % and specificity to 88 %. The mean functional rate in patients with pancreatic disease was significantly lower (33.3+-24.5 in patients with chronic pancreatitis, 28.1+-26.9 in patients with acute pancreatitis, 43.4+-22.3 in patients with diabetes mellitus, 20.4+-23.4 in patients with pancreatic cancer) than the mean functional rate in cases without pancreatic disease (86.4+-14.2). It is suggested that functional image of the pancreas reflecting pancreatic exocrine function and functional rate is a useful indicator of pancreatic exocrine function. (author)

  6. Functional hepatocellular regeneration measured by hepatobiliary scintigraphy, functional regeneration or functional hepatocytes?

    NARCIS (Netherlands)

    Olthof, Pim B.; Cieslak, Kasia P.; Bennink, Roelof J.; van Gulik, Thomas M.

    2016-01-01

    In a recent issue of this journal, Fernandes et al(1) reported on functional hepatocellular regeneration in elderly patients undergoing hepatectomy. They used (99m) Tc-mebrofinin HBS to quantify liver function before and after surgery and concluded that functional regeneration is already present at

  7. Statistical model based iterative reconstruction (MBIR) in clinical CT systems. Part II. Experimental assessment of spatial resolution performance

    International Nuclear Information System (INIS)

    Li, Ke; Chen, Guang-Hong; Garrett, John; Ge, Yongshuai

    2014-01-01

    Purpose: Statistical model based iterative reconstruction (MBIR) methods have been introduced to clinical CT systems and are being used in some clinical diagnostic applications. The purpose of this paper is to experimentally assess the unique spatial resolution characteristics of this nonlinear reconstruction method and identify its potential impact on the detectabilities and the associated radiation dose levels for specific imaging tasks. Methods: The thoracic section of a pediatric phantom was repeatedly scanned 50 or 100 times using a 64-slice clinical CT scanner at four different dose levels [CTDI vol =4, 8, 12, 16 (mGy)]. Both filtered backprojection (FBP) and MBIR (Veo ® , GE Healthcare, Waukesha, WI) were used for image reconstruction and results were compared with one another. Eight test objects in the phantom with contrast levels ranging from 13 to 1710 HU were used to assess spatial resolution. The axial spatial resolution was quantified with the point spread function (PSF), while the z resolution was quantified with the slice sensitivity profile. Both were measured locally on the test objects and in the image domain. The dependence of spatial resolution on contrast and dose levels was studied. The study also features a systematic investigation of the potential trade-off between spatial resolution and locally defined noise and their joint impact on the overall image quality, which was quantified by the image domain-based channelized Hotelling observer (CHO) detectability index d′. Results: (1) The axial spatial resolution of MBIR depends on both radiation dose level and image contrast level, whereas it is supposedly independent of these two factors in FBP. The axial spatial resolution of MBIR always improved with an increasing radiation dose level and/or contrast level. (2) The axial spatial resolution of MBIR became equivalent to that of FBP at some transitional contrast level, above which MBIR demonstrated superior spatial resolution than FBP (and

  8. Respiratory function and functional capacity in chronic stroke patients 1

    OpenAIRE

    Machado, Anna Cláudia Martinez; Silva, Nathália Grasielle Marinho; Diniz, Gisele do Carmo Leite; Pessoa, Bruno Porto; Scalzo, Paula Luciana

    2016-01-01

    Abstract Introduction: Cerebrovascular accident (CVA) or stroke results in weakness of the trunk muscles and physical unfitness. Objectives: To evaluate respiratory changes caused by stroke and correlate them with the functional capacity of chronic stroke patients who were treated at the Clinical Center of Physical Therapy of the Pontifical Catholic University of Minas Gerais, Betim. Methods: Fifteen patients were recruited for assessment of respiratory function and functional capacity. W...

  9. Wigner's function and other distribution functions in mock phase spaces

    International Nuclear Information System (INIS)

    Balazs, N.L.; Jennings, B.K.

    1983-06-01

    This review deals with the methods of associating functions with quantum mechanical operators in such a manner that these functions should furnish conveniently semiclassical approximations. We present a unified treatment of methods and result which usually appear under the expressions Wigner's functions, Weyl's association, Kirkwood's expansion, Glauber's coherent state representation, etc.; we also construct some new associations. The mathematical paraphernalia are collected in the appendices

  10. On harmonic morphisms projecting harmonic functions to harmonic functions

    International Nuclear Information System (INIS)

    Mustafa, M.T.

    2002-08-01

    For Riemannian manifolds M and N. admitting a submersive harmonic morphism φ with compact fibres, we introduce the vertical and horizontal components of a real-valued function f on V is contained in M. By comparing the Laplacians on M and N. we determine conditions under which a harmonic function on V=φ -1 (U) is contained in M projects down, via its horizontal component, to a harmonic function on U is contained in N. (author)

  11. Discovery of functional and approximate functional dependencies in relational databases

    Directory of Open Access Journals (Sweden)

    Ronald S. King

    2003-01-01

    Full Text Available This study develops the foundation for a simple, yet efficient method for uncovering functional and approximate functional dependencies in relational databases. The technique is based upon the mathematical theory of partitions defined over a relation's row identifiers. Using a levelwise algorithm the minimal non-trivial functional dependencies can be found using computations conducted on integers. Therefore, the required operations on partitions are both simple and fast. Additionally, the row identifiers provide the added advantage of nominally identifying the exceptions to approximate functional dependencies, which can be used effectively in practical data mining applications.

  12. Transfer Function Identification Using Orthogonal Fourier Transform Modeling Functions

    Science.gov (United States)

    Morelli, Eugene A.

    2013-01-01

    A method for transfer function identification, including both model structure determination and parameter estimation, was developed and demonstrated. The approach uses orthogonal modeling functions generated from frequency domain data obtained by Fourier transformation of time series data. The method was applied to simulation data to identify continuous-time transfer function models and unsteady aerodynamic models. Model fit error, estimated model parameters, and the associated uncertainties were used to show the effectiveness of the method for identifying accurate transfer function models from noisy data.

  13. Cell functional enviromics: Unravelling the function of environmental factors

    Directory of Open Access Journals (Sweden)

    Alves Paula M

    2011-06-01

    Full Text Available Abstract Background While functional genomics, focused on gene functions and gene-gene interactions, has become a very active field of research in molecular biology, equivalent methodologies embracing the environment and gene-environment interactions are relatively less developed. Understanding the function of environmental factors is, however, of paramount importance given the complex, interactive nature of environmental and genetic factors across multiple time scales. Results Here, we propose a systems biology framework, where the function of environmental factors is set at its core. We set forth a "reverse" functional analysis approach, whereby cellular functions are reconstructed from the analysis of dynamic envirome data. Our results show these data sets can be mapped to less than 20 core cellular functions in a typical mammalian cell culture, while explaining over 90% of flux data variance. A functional enviromics map can be created, which provides a template for manipulating the environmental factors to induce a desired phenotypic trait. Conclusion Our results support the feasibility of cellular function reconstruction guided by the analysis and manipulation of dynamic envirome data.

  14. Spontaneous processing of functional and non-functional action sequences

    DEFF Research Database (Denmark)

    Nielbo, Kristoffer Laigaard; Sørensen, Jesper

    2011-01-01

    as sub-categories of non-functional behavior (i.e., actions lacking causal coherence and a necessary integration between subparts). New insights in human action processing can help us explain how cognition might vary depending on the type of behavior processed. Using an event segmentation paradigm, we...... conducted two experiments eliciting differences in participants' response patterns to functional and non-functional actions. Participants consistently segmented non-functional action sequences into smaller units indicating either an attentional shift to the level of gesture analysis or a problem...

  15. 309 Building deactivation function analysis report

    International Nuclear Information System (INIS)

    Lund, D.P.

    1995-09-01

    The document contains the functions, function definitions, function interfaces, function interface definitions, Input Computer Automated Manufacturing Definition (IDEFO) diagrams, and a function hierarchy chart that describe what needs to be performed to deactivate the 309 Building

  16. PUREX Plant deactivation function analysis report

    International Nuclear Information System (INIS)

    Lund, D.P.

    1995-09-01

    The document contains the functions, function definitions, function interfaces, function interface definitions, Input Computer Automated Manufacturing Definition (IDEFO) diagrams, and a function hierarchy chart that describe what needs to be performed to deactivate PUREX

  17. FFTF Plant transition function analysis report

    International Nuclear Information System (INIS)

    Lund, D.P.

    1995-09-01

    The document contains the functions, function definitions, function interfaces, function interface definitions, Input Computer Automated Manufacturing Definition (IDEFO) diagrams, and function hierarchy charts that describe what needs to be performed to deactivate FFTF

  18. 308 Building deactivation function analysis report

    International Nuclear Information System (INIS)

    Lund, D.P.

    1995-09-01

    The document contains the functions, function definitions, function interfaces, function interface definitions, Input Computer Automated Manufacturing Definition (IDEFO) diagrams, and a function hierarchy chart that describes what needs to be performed to deactivate the 308 Building

  19. Methods of making functionalized nanorods

    Science.gov (United States)

    Gur, Ilan [San Francisco, CA; Milliron, Delia [Berkeley, CA; Alivisatos, A Paul [Oakland, CA; Liu, Haitao [Berkeley, CA

    2012-01-10

    A process for forming functionalized nanorods. The process includes providing a substrate, modifying the substrate by depositing a self-assembled monolayer of a bi-functional molecule on the substrate, wherein the monolayer is chosen such that one side of the bi-functional molecule binds to the substrate surface and the other side shows an independent affinity for binding to a nanocrystal surface, so as to form a modified substrate. The process further includes contacting the modified substrate with a solution containing nanocrystal colloids, forming a bound monolayer of nanocrystals on the substrate surface, depositing a polymer layer over the monolayer of nanocrystals to partially cover the monolayer of nanocrystals, so as to leave a layer of exposed nanocrystals, functionalizing the exposed nanocrystals, to form functionalized nanocrystals, and then releasing the functionalized nanocrystals from the substrate.

  20. Geometric Operators on Boolean Functions

    DEFF Research Database (Denmark)

    Frisvad, Jeppe Revall; Falster, Peter

    In truth-functional propositional logic, any propositional formula represents a Boolean function (according to some valuation of the formula). We describe operators based on Decartes' concept of constructing coordinate systems, for translation of a propositional formula to the image of a Boolean...... function. With this image of a Boolean function corresponding to a propositional formula, we prove that the orthogonal projection operator leads to a theorem describing all rules of inference in propositional reasoning. In other words, we can capture all kinds of inference in propositional logic by means...... of a few geometric operators working on the images of Boolean functions. The operators we describe, arise from the niche area of array-based logic and have previously been tightly bound to an array-based representation of Boolean functions. We redefine the operators in an abstract form to make them...

  1. An introduction to special functions

    CERN Document Server

    Viola, Carlo

    2016-01-01

    The subjects treated in this book have been especially chosen to represent a bridge connecting the content of a first course on the elementary theory of analytic functions with a rigorous treatment of some of the most important special functions: the Euler gamma function, the Gauss hypergeometric function, and the Kummer confluent hypergeometric function. Such special functions are indispensable tools in "higher calculus" and are frequently encountered in almost all branches of pure and applied mathematics. The only knowledge assumed on the part of the reader is an understanding of basic concepts to the level of an elementary course covering the residue theorem, Cauchy's integral formula, the Taylor and Laurent series expansions, poles and essential singularities, branch points, etc. The book addresses the needs of advanced undergraduate and graduate students in mathematics or physics.

  2. Mechanics of advanced functional materials

    CERN Document Server

    Wang, Biao

    2013-01-01

    Mechanics of Advanced Functional Materials emphasizes the coupling effect between the electric and mechanical field in the piezoelectric, ferroelectric and other functional materials. It also discusses the size effect on the ferroelectric domain instability and phase transition behaviors using the continuum micro-structural evolution models. Functional materials usually have a very wide application in engineering due to their unique thermal, electric, magnetic, optoelectronic, etc., functions. Almost all the applications demand that the material should have reasonable stiffness, strength, fracture toughness and the other mechanical properties. Furthermore, usually the stress and strain fields on the functional materials and devices have some important coupling effect on the functionality of the materials. Much progress has been made concerning the coupling electric and mechanical behaviors such as the coupled electric and stress field distribution in piezoelectric solids, ferroelectric domain patterns in ferr...

  3. The relativity of biological function.

    Science.gov (United States)

    Laubichler, Manfred D; Stadler, Peter F; Prohaska, Sonja J; Nowick, Katja

    2015-12-01

    Function is a central concept in biological theories and explanations. Yet discussions about function are often based on a narrow understanding of biological systems and processes, such as idealized molecular systems or simple evolutionary, i.e., selective, dynamics. Conflicting conceptions of function continue to be used in the scientific literature to support certain claims, for instance about the fraction of "functional DNA" in the human genome. Here we argue that all biologically meaningful interpretations of function are necessarily context dependent. This implies that they derive their meaning as well as their range of applicability only within a specific theoretical and measurement context. We use this framework to shed light on the current debate about functional DNA and argue that without considering explicitly the theoretical and measurement contexts all attempts to integrate biological theories are prone to fail.

  4. Methylmercury toxicity and functional programming.

    Science.gov (United States)

    Grandjean, Philippe

    2007-01-01

    Adverse health effects of developmental toxicants may induce abnormal functional programming that leads to lasting functional deficits. This notion is considered from epidemiological evidence using developmental methylmercury neurotoxicity as an example. Accumulating evidence indicates that adverse effects may occur even at low-level methylmercury exposures from seafood and freshwater fish. Neurobehavioral outcomes are usually non-specific, and imprecise exposure assessment results in a bias toward the null. Essential nutrients may promote the development of certain brain functions, thereby causing confounding bias. The functional deficits caused by prenatal methylmercury exposure appear to be permanent, and their extent may depend on the joint effect of toxicants and nutrients. The lasting functional changes caused by neurodevelopmental methylmercury toxicity fit into the pattern of functional programming, with effects opposite to those linked to beneficial stimuli.

  5. Dansk skepsis mod "functional foods"

    DEFF Research Database (Denmark)

    Bech-Larsen, Tino

    2000-01-01

    MAPP Centret har undersøgt danske, finske og amerikanske forbrugeres holdninger til functional foods og til genmodificerede fødevarer. Undersøgelsen er baseret på personlige interviews med 1500 danske, finske og nordamerikanske forbrugere. På trods af den store udbredelse af functional foods i USA......, viste undersøgelsen, at finnerne faktisk var mere positive over for functional foods end amerikanerne. De danske forbrugere var klart de mest skeptiske....

  6. Morse functions with sphere fibers

    OpenAIRE

    Saeki, Osamu

    2006-01-01

    A smooth closed manifold is said to be an almost sphere if it admits a Morse function with exactly two critical points. In this paper, we characterize those smooth closed manifolds which admit Morse functions such that each regular fiber is a finite disjoint union of almost spheres. We will see that such manifolds coincide with those which admit Morse functions with at most three critical values. As an application, we give a new proof of the characterization theorem of those closed manifolds ...

  7. Covering Numbers for Semicontinuous Functions

    Science.gov (United States)

    2016-04-29

    Although a comparison to the classical result of O(ε−d) for Lipschitz continuous functions on bounded subsets, which goes back to [17] (see for...Covering Numbers for Semicontinuous Functions Johannes O. Royset Operations Research Department Naval Postgraduate School joroyset@nps.edu Abstract...Considering the metric space of extended real-valued lower semicontinuous functions under the epi-distance, the paper gives an upper bound on the

  8. Functional footprinting of regulatory DNA.

    Science.gov (United States)

    Vierstra, Jeff; Reik, Andreas; Chang, Kai-Hsin; Stehling-Sun, Sandra; Zhou, Yuanyue; Hinkley, Sarah J; Paschon, David E; Zhang, Lei; Psatha, Nikoletta; Bendana, Yuri R; O'Neil, Colleen M; Song, Alexander H; Mich, Andrea K; Liu, Pei-Qi; Lee, Gary; Bauer, Daniel E; Holmes, Michael C; Orkin, Stuart H; Papayannopoulou, Thalia; Stamatoyannopoulos, George; Rebar, Edward J; Gregory, Philip D; Urnov, Fyodor D; Stamatoyannopoulos, John A

    2015-10-01

    Regulatory regions harbor multiple transcription factor (TF) recognition sites; however, the contribution of individual sites to regulatory function remains challenging to define. We describe an approach that exploits the error-prone nature of genome editing-induced double-strand break repair to map functional elements within regulatory DNA at nucleotide resolution. We demonstrate the approach on a human erythroid enhancer, revealing single TF recognition sites that gate the majority of downstream regulatory function.

  9. Mandarin functional MRI Language paradigms

    OpenAIRE

    Ci, He; van Graan, Andre; Gonz?lvez, Gloria; Thompson, Pamela; Hill, Andrea; Duncan, John S.

    2016-01-01

    Abstract Objective The objective of this study was to implement convenient, fast, and accurate Mandarin task paradigms for functional MRI, and to locate the Chinese language functional areas in frontal and temporal lobes. Materials and Methods Nineteen healthy Chinese volunteers participated in this study, which utilized a block design with four language tasks: auditory naming (AN), picture naming (PN), verbal fluency?character (VFC), and verbal fluency?letter (VFL). All functional images wer...

  10. Domains of bosonic functional integrals

    International Nuclear Information System (INIS)

    Botelho, Luiz C.L.; Para Univ., Belem, PA

    1998-07-01

    We propose a mathematical framework for bosonic Euclidean quantum field functional integrals based on the theory of integration on the dual algebraic vector space of classical field sources. We present a generalization of the Minlos-Dao Xing theorem and apply it to determine exactly the domain of integration associated to the functional integral representation of the two-dimensional quantum electrodynamics Schwinger generating functional. (author)

  11. Functional representations of integrable hierarchies

    International Nuclear Information System (INIS)

    Dimakis, Aristophanes; Mueller-Hoissen, Folkert

    2006-01-01

    We consider a general framework for integrable hierarchies in Lax form and derive certain universal equations from which 'functional representations' of particular hierarchies (such as KP, discrete KP, mKP, AKNS), i.e. formulations in terms of functional equations, are systematically and quite easily obtained. The formalism genuinely applies to hierarchies where the dependent variables live in a noncommutative (typically matrix) algebra. The obtained functional representations can be understood as 'noncommutative' analogues of 'Fay identities' for the KP hierarchy

  12. Imaging of brain function based on the analysis of functional ...

    African Journals Online (AJOL)

    Results: The right cerebrum temporal lobe was selected as the seed point to analyze the functional connectivity. It had a functional connectivity with right cerebrum superior frontal gyrus, limbic lobe cingulate gyrus and left cerebrum inferior temporal gyrus (BA 37), inferior parietal lobule compared by before vs. after ...

  13. Approximation of Analytic Functions by Bessel's Functions of Fractional Order

    Directory of Open Access Journals (Sweden)

    Soon-Mo Jung

    2011-01-01

    Full Text Available We will solve the inhomogeneous Bessel's differential equation x2y″(x+xy′(x+(x2-ν2y(x=∑m=0∞amxm, where ν is a positive nonintegral number and apply this result for approximating analytic functions of a special type by the Bessel functions of fractional order.

  14. On functions defined by sums of products of Bessel functions

    International Nuclear Information System (INIS)

    Martin, P A

    2008-01-01

    Various functions, defined as infinite series of products of Bessel functions of the first kind, are studied. Integral representations are obtained, and then used to deduce asymptotic approximations. Although several methods have been investigated (including power series expansions and integral transforms), methods based on Fourier series emerge as the most useful

  15. Harmonic functions with varying coefficients

    Directory of Open Access Journals (Sweden)

    Jacek Dziok

    2016-05-01

    Full Text Available Abstract Complex-valued harmonic functions that are univalent and sense preserving in the open unit disk can be written in the form f = h + g ‾ $f=h+\\overline{g}$ , where h and g are analytic. In this paper we investigate some classes of univalent harmonic functions with varying coefficients related to Janowski functions. By using the extreme points theory we obtain necessary and sufficient convolution conditions, coefficients estimates, distortion theorems, and integral mean inequalities for these classes of functions. The radii of starlikeness and convexity for these classes are also determined.

  16. A deterministic width function model

    Directory of Open Access Journals (Sweden)

    C. E. Puente

    2003-01-01

    Full Text Available Use of a deterministic fractal-multifractal (FM geometric method to model width functions of natural river networks, as derived distributions of simple multifractal measures via fractal interpolating functions, is reported. It is first demonstrated that the FM procedure may be used to simulate natural width functions, preserving their most relevant features like their overall shape and texture and their observed power-law scaling on their power spectra. It is then shown, via two natural river networks (Racoon and Brushy creeks in the United States, that the FM approach may also be used to closely approximate existing width functions.

  17. Functional statistics and related fields

    CERN Document Server

    Bongiorno, Enea; Cao, Ricardo; Vieu, Philippe

    2017-01-01

    This volume collects latest methodological and applied contributions on functional, high-dimensional and other complex data, related statistical models and tools as well as on operator-based statistics. It contains selected and refereed contributions presented at the Fourth International Workshop on Functional and Operatorial Statistics (IWFOS 2017) held in A Coruña, Spain, from 15 to 17 June 2017. The series of IWFOS workshops was initiated by the Working Group on Functional and Operatorial Statistics at the University of Toulouse in 2008. Since then, many of the major advances in functional statistics and related fields have been periodically presented and discussed at the IWFOS workshops. .

  18. Green's functions in quantum physics

    CERN Document Server

    Economou, Eleftherios N

    2006-01-01

    The main part of this book is devoted to the simplest kind of Green's functions, namely the solutions of linear differential equations with a -function source. It is shown that these familiar Green's functions are a powerful tool for obtaining relatively simple and general solutions of basic problems such as scattering and bound-level information. The bound-level treatment gives a clear physical understanding of "difficult" questions such as superconductivity, the Kondo effect, and, to a lesser degree, disorder-induced localization. The more advanced subject of many-body Green's functions is presented in the last part of the book.

  19. Prestarlike functions with negative coefficients

    Directory of Open Access Journals (Sweden)

    H. Silverman

    1979-01-01

    Full Text Available The extreme points for prestarlike functions having negative coefficients are determined. Coefficient, distortion and radii of univalence, starlikeness, and convexity theorems are also obtained.

  20. Molecular calculations with B functions

    International Nuclear Information System (INIS)

    Steinborn, E.O.; Homeier, H.H.H.; Ema, I.; Lopez, R.; Ramirez, G.

    2000-01-01

    A program for molecular calculations with B functions is reported and its performance is analyzed. All the one- and two-center integrals and the three-center nuclear attraction integrals are computed by direct procedures, using previously developed algorithms. The three- and four-center electron repulsion integrals are computed by means of Gaussian expansions of the B functions. A new procedure for obtaining these expansions is also reported. Some results on full molecular calculations are included to show the capabilities of the program and the quality of the B functions to represent the electronic functions in molecules

  1. Assessing Respiratory System Mechanical Function.

    Science.gov (United States)

    Restrepo, Ruben D; Serrato, Diana M; Adasme, Rodrigo

    2016-12-01

    The main goals of assessing respiratory system mechanical function are to evaluate the lung function through a variety of methods and to detect early signs of abnormalities that could affect the patient's outcomes. In ventilated patients, it has become increasingly important to recognize whether respiratory function has improved or deteriorated, whether the ventilator settings match the patient's demand, and whether the selection of ventilator parameters follows a lung-protective strategy. Ventilator graphics, esophageal pressure, intra-abdominal pressure, and electric impedance tomography are some of the best-known monitoring tools to obtain measurements and adequately evaluate the respiratory system mechanical function. Copyright © 2016 Elsevier Inc. All rights reserved.

  2. Wigner functions of s waves

    DEFF Research Database (Denmark)

    Dahl, Jens Peder; Varro, S.; Wolf, A.

    2007-01-01

    We derive explicit expressions for the Wigner function of wave functions in D dimensions which depend on the hyperradius-that is, of s waves. They are based either on the position or the momentum representation of the s wave. The corresponding Wigner function depends on three variables......: the absolute value of the D-dimensional position and momentum vectors and the angle between them. We illustrate these expressions by calculating and discussing the Wigner functions of an elementary s wave and the energy eigenfunction of a free particle....

  3. Center for Functional Nanomaterials (CFN)

    Data.gov (United States)

    Federal Laboratory Consortium — The CFN at Brookhaven National Laboratory focuses on understanding the chemical and physical response of nanomaterials to make functional materials such as sensors,...

  4. A critique of functional localisers.

    Science.gov (United States)

    Friston, K J; Rotshtein, P; Geng, J J; Sterzer, P; Henson, R N

    2006-05-01

    In this critique, we review the usefulness of functional localising scans in functional MRI studies. We consider their conceptual motivations and the implications for experimental design and inference. Functional localisers can often be viewed as acquiring data from cells that have been removed from an implicit factorial design. This perspective reveals their potentially restrictive nature. We deconstruct two examples from the recent literature to highlight the key issues. We conclude that localiser scans can be unnecessary and, in some instances, lead to a biased and inappropriately constrained characterisation of functional anatomy.

  5. Supersymmetry Inspired QCD Beta Function

    DEFF Research Database (Denmark)

    Ryttov, Thomas; Sannino, Francesco

    2008-01-01

    We propose an all orders beta function for ordinary Yang-Mills theories with or without fermions inspired by the Novikov-Shifman-Vainshtein-Zakharov beta function of N=1 supersymmetric gauge theories. The beta function allows us to bound the conformal window. When restricting to one adjoint Weyl...... fermion we show how the proposed beta function matches the one of supersymmetric Yang-Mills theory. The running of the pure Yang-Mills coupling is computed and the deviation from the two loop result is presented. We then compare the deviation with the one obtained from lattice data also with respect...

  6. Correlation Functions and Power Spectra

    DEFF Research Database (Denmark)

    Larsen, Jan

    2006-01-01

    The present lecture note is a supplement to the textbook Digital Signal Processing by J. Proakis and D.G. Manolakis used in the IMM/DTU course 02451 Digital Signal Processing and provides an extended discussion of correlation functions and power spectra. The definitions of correlation functions....... It is possible to define correlation functions and associated spectra for aperiodic, periodic and random signals although the interpretation is different. Moreover, we will discuss correlation functions when mixing these basic signal types. In addition, the note include several examples for the purpose...

  7. Autonomous functioning of the goitre

    International Nuclear Information System (INIS)

    Emrich, D.

    1994-01-01

    The article summarizes the status of knowledge on functional autonomy of the thyroid gland from the standpoint of definition, pathogenesis, pathophysiology, epidemiology, diagnostics and treatment. (orig.) [de

  8. What dentition assures oral function?

    DEFF Research Database (Denmark)

    Gotfredsen, Klaus; Walls, Angus W G

    2007-01-01

    specific areas of oral function were addressed; (I) masticatory function, (II) aesthetics, satisfaction and psychosocial ability, (III) occlusal support and stability and (IV) other functionality including tactile perception, phonetics and taste. RESULTS: From an initial pool of 1460 citations, 83 articles...... groups, social classes, cultures, regions and countries. For most people, occlusal support and stability are obtained with three to four functional posterior units with a symmetrical pattern of tooth loss or five to six units with an asymmetrical pattern. There was no relationship between occlusal...

  9. Incorporating functional inter-relationships into protein function prediction algorithms

    Directory of Open Access Journals (Sweden)

    Kumar Vipin

    2009-05-01

    Full Text Available Abstract Background Functional classification schemes (e.g. the Gene Ontology that serve as the basis for annotation efforts in several organisms are often the source of gold standard information for computational efforts at supervised protein function prediction. While successful function prediction algorithms have been developed, few previous efforts have utilized more than the protein-to-functional class label information provided by such knowledge bases. For instance, the Gene Ontology not only captures protein annotations to a set of functional classes, but it also arranges these classes in a DAG-based hierarchy that captures rich inter-relationships between different classes. These inter-relationships present both opportunities, such as the potential for additional training examples for small classes from larger related classes, and challenges, such as a harder to learn distinction between similar GO terms, for standard classification-based approaches. Results We propose a method to enhance the performance of classification-based protein function prediction algorithms by addressing the issue of using these interrelationships between functional classes constituting functional classification schemes. Using a standard measure for evaluating the semantic similarity between nodes in an ontology, we quantify and incorporate these inter-relationships into the k-nearest neighbor classifier. We present experiments on several large genomic data sets, each of which is used for the modeling and prediction of over hundred classes from the GO Biological Process ontology. The results show that this incorporation produces more accurate predictions for a large number of the functional classes considered, and also that the classes benefitted most by this approach are those containing the fewest members. In addition, we show how our proposed framework can be used for integrating information from the entire GO hierarchy for improving the accuracy of

  10. Prediction Error During Functional and Non-Functional Action Sequences

    DEFF Research Database (Denmark)

    Nielbo, Kristoffer Laigaard; Sørensen, Jesper

    2013-01-01

    behavioral study has shown that human subjects segment non-functional behavior in a more fine-grained way than functional behavior. This increase in segmentation rate implies that non-functionality elicits a stronger error signal. To further explore the implications, two computer simulations using simple...... error. Non-functionality in this proximal sense is a feature of many socio-cultural practices, such as those found in religious rituals private and social, as well as pathological practices, such as ritualized behavior found among people suffering from Obsessive Compulsory Disorder (OCD). A recent...... recurrent networks were made and the results are presented in this article. The simulations show that non-functional action sequences do indeed increase prediction error, but that context representations, such as abstract goal information, can modulate the error signal considerably. It is also shown...

  11. Functional enrichment analyses and construction of functional similarity networks with high confidence function prediction by PFP

    Directory of Open Access Journals (Sweden)

    Kihara Daisuke

    2010-05-01

    Full Text Available Abstract Background A new paradigm of biological investigation takes advantage of technologies that produce large high throughput datasets, including genome sequences, interactions of proteins, and gene expression. The ability of biologists to analyze and interpret such data relies on functional annotation of the included proteins, but even in highly characterized organisms many proteins can lack the functional evidence necessary to infer their biological relevance. Results Here we have applied high confidence function predictions from our automated prediction system, PFP, to three genome sequences, Escherichia coli, Saccharomyces cerevisiae, and Plasmodium falciparum (malaria. The number of annotated genes is increased by PFP to over 90% for all of the genomes. Using the large coverage of the function annotation, we introduced the functional similarity networks which represent the functional space of the proteomes. Four different functional similarity networks are constructed for each proteome, one each by considering similarity in a single Gene Ontology (GO category, i.e. Biological Process, Cellular Component, and Molecular Function, and another one by considering overall similarity with the funSim score. The functional similarity networks are shown to have higher modularity than the protein-protein interaction network. Moreover, the funSim score network is distinct from the single GO-score networks by showing a higher clustering degree exponent value and thus has a higher tendency to be hierarchical. In addition, examining function assignments to the protein-protein interaction network and local regions of genomes has identified numerous cases where subnetworks or local regions have functionally coherent proteins. These results will help interpreting interactions of proteins and gene orders in a genome. Several examples of both analyses are highlighted. Conclusion The analyses demonstrate that applying high confidence predictions from PFP

  12. Study of quark structure functions

    International Nuclear Information System (INIS)

    Dao, F.T.; Flaminio, E.; Lai, K.; Metcalf, M.; Wang, L.

    1977-01-01

    The quark structure functions of the proton are determined through a combined analysis of the reactions pN → ll-barX and eN → eX. The valence-quark structure function of the pion is also given by analyzing the πN → μμ-barX data measured by the Branson et al

  13. Functions in Biological Kind Classification

    Science.gov (United States)

    Lombrozo, Tania; Rehder, Bob

    2012-01-01

    Biological traits that serve functions, such as a zebra's coloration (for camouflage) or a kangaroo's tail (for balance), seem to have a special role in conceptual representations for biological kinds. In five experiments, we investigate whether and why functional features are privileged in biological kind classification. Experiment 1…

  14. Incentives in Supply Function Equilibrium

    DEFF Research Database (Denmark)

    Vetter, Henrik

    2014-01-01

    The author analyses delegation in homogenous duopoly under the assumption that the firm-managers compete in supply functions. In supply function equilibrium, managers’ decisions are strategic complements. This reverses earlier findings in that the author finds that owners give managers incentives...

  15. Weights of Exact Threshold Functions

    DEFF Research Database (Denmark)

    Babai, László; Hansen, Kristoffer Arnsfelt; Podolskii, Vladimir V.

    2010-01-01

    We consider Boolean exact threshold functions defined by linear equations, and in general degree d polynomials. We give upper and lower bounds on the maximum magnitude (absolute value) of the coefficients required to represent such functions. These bounds are very close and in the linear case in ...... leave a substantial gap, a challenge for future work....

  16. Cosmetic and Functional Nasal Deformities

    Science.gov (United States)

    ... nasal complaints. Nasal deformity can be categorized as “cosmetic” or “functional.” Cosmetic deformity of the nose results in a less ... taste , nose bleeds and/or recurrent sinusitis . A cosmetic or functional nasal deformity may occur secondary to ...

  17. Limb vascular function in women

    DEFF Research Database (Denmark)

    Hellsten, Ylva; Gliemann, Lasse

    2018-01-01

    tone and oxidative stress and thereby functions such as oxygen delivery and blood pressure. The acute hormonal fluctuations do not substantially impact health, but their influence should be considered with regard to measurements of vascular function. The chronic hormonal change with menopause strongly...

  18. Parotid gland function after radiotherapy

    NARCIS (Netherlands)

    Roesink, Judith Maria

    2005-01-01

    Radiotherapy is a common treatment for head and neck cancer patients. Unfortunately, it produces serious acute and long-term side effects to the oral cavity. One severe complication is the loss of salivary gland function, which can persists for many years. Saliva has multiple functions relating to

  19. The Statistics of a Function

    Science.gov (United States)

    Gordon, Sheldon P.; Gordon, Florence S.

    2010-01-01

    One of the most important applications of the definite integral in a modern calculus course is the mean value of a function. Thus, if a function "f" is defined on an interval ["a", "b"], then the mean, or average value, of "f" is given by [image omitted]. In this note, we will investigate the meaning of other statistics associated with a function…

  20. Proposals for Iterated Hash Functions

    DEFF Research Database (Denmark)

    Knudsen, Lars Ramkilde; Thomsen, Søren Steffen

    2008-01-01

    some generic attacks. We also give a concrete proposal for a new hash function construction, given a secure compression function which, unlike in typical existing constructions, is not required to be resistant to all types of collisions. Finally, we show how members of the SHA-family can be turned...... into constructions of our proposed type....