Dendritic cells loaded with HeLa-derived exosomes simulate an antitumor immune response.

Science.gov (United States)

Ren, Guoping; Wang, Yanhong; Yuan, Shexia; Wang, Baolian

2018-05-01

The aim of the present study was to investigate the effect of loading dendritic cells (DCs) with HeLa-derived exosomes on cytotoxic T-lymphocyte (CTL) responses, and the cytotoxic effects of CTL responses on the HeLa cell line. Ultrafiltration centrifugation combined with sucrose density gradient ultracentrifugation was applied to isolate exosomes (HeLa-exo) from the supernatant of HeLa cells. Morphological features of HeLa-exo were identified by transmission electron microscopy (TEM), and the expression of cluster of differentiation (CD)63 was detected by western blotting. Next, monocytes were isolated from peripheral blood and cultured with the removal of adherent cells to induce DC proliferation. DCs were then phenotypically characterized by flow cytometry. Finally, MTT assays were performed to analyze the effects of DCs loaded with HeLa-exo on T cell proliferation and cytotoxicity assays to evaluate the effect of CTL responses on HeLa cells. TEM revealed that HeLa-exo exhibit typical cup-shaped morphology with a diameter range of 30-100 nm. It was also identified that the CD63 surface antigen is expressed on HeLa-exo. Furthermore, monocyte-derived DCs were able to express CD1a, suggesting that DC induction was a success. DCs exhibited hair-like protrusions and other typical dendritic cell morphology. Furthermore, DCs loaded with HeLa-exo could enhance CTL proliferation and the cytotoxic activity of CTLs compared with DCs without HeLa-exo (PHeLa-exo may promote T cell proliferation and induce CTL responses to inhibit the growth of cervical cancer cells in vitro .

Efecto de la Temperatura sobre la Viscosidad de Soluciones Acuosas Diluidas de 1,2-Pentanodiol Effect of the Temperature on the Viscosity of Diluted Aqueous Solutions of 1,2-Pentanediol

OpenAIRE

Manuel S Páez; Jennifer Lafont; Alfonso A Portacio

2009-01-01

Se determinó la viscosidad de las soluciones acuosas diluidas de 1,2-pentanodiol a varias temperaturas entre 283 y 308 K usando un viscosímetro Ubbelohde. Se evaluaron los coeficientes B de viscosidad, la variación dB/dT, la entalpía, entropía y energía libre de Gibbs de activación. Se encontró que el coeficiente B, disminuye con el aumento de la temperatura. Los valores obtenidos para dB/dT son pequeños y negativos para todas las temperaturas, lo cual indica que el 1,2-pentanodiol tiene un e...

Haenamindole, an unusual diketopiperazine derivative from a marine-derived Penicillium sp. KCB12F005.

Science.gov (United States)

Kim, Jong Won; Ko, Sung-Kyun; Son, Sangkeun; Shin, Kee-Sun; Ryoo, In-Ja; Hong, Young-Soo; Oh, Hyuncheol; Hwang, Bang Yeon; Hirota, Hiroshi; Takahashi, Shunji; Kim, Bo Yeon; Osada, Hiroyuki; Jang, Jae-Hyuk; Ahn, Jong Seog

2015-11-15

During the chemical investigation of marine-derived fungus, an unusual diketopiperazine (DKP) alkaloid, haenamindole (1), was isolated from a culture of the marine-derived fungus Penicillium sp. KCB12F005. The structure of 1, which possesses benzyl-hydroxypiperazindione and phenyl-pyrimidoindole rings system in the molecule, was elucidated by analysis of NMR and MS data. The stereochemistry of 1 was determined by ROESY and advanced Marfey's method. Copyright © 2015 Elsevier Ltd. All rights reserved.

17 CFR 240.3b-12 - Definition of OTC derivatives dealer.

Science.gov (United States)

2010-04-01

... to options, forwards, futures, swap agreements, or collars involving currencies, interest or other... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Definition of OTC derivatives... Securities Exchange Act of 1934 Definitions § 240.3b-12 Definition of OTC derivatives dealer. The term OTC...

Evaluation of the antitumor activity of interleukin-12 in an experimental murine model of colorectal cancer induced by 1,2 dimethylhydrazine (DMH Estudio de la respuesta antitumoral de la interleucina-12 en cáncer de colon inducido mediante 1,2-dimetilhidracina (DMH

Directory of Open Access Journals (Sweden)

S. Coca

2005-09-01

I (p=0.028 and group III (p = 0.019. Other parameters measured, such as biggest tumor size and total tumoral volume were found to be lower in group II, although no statistical differences were found between groups. Only 10% of rats in group I showed moderated/extensive NK cell infiltration, vs. 60% of rats in group II (p = 0.077 and 70% in group III (p = 0.02. Conclusion: The administration of DMH to rodents provides a reliable and consistent means of inducing CRC that may be suitable for the evaluation of anti-cancer therapies. Our findings suggest that IL-12 is effective against the development of experimental CRC. Its antineoplastic effect could be attributed to the stimulus of this cytokine on the intratumoral infiltration of NK cells.Objetivo: la interleucina (IL-12 es una citocina que estimula la proliferación y la actividad citotóxica de los linfocito T y las células natural killer (NK. En trabajos previos se ha observado una relación entre la infiltración intratumoral de células NK y una mayor supervivencia en carcinomas colorrectales (CCR. Existen evidencias de un efecto aditivo en la actividad inmunomoduladora de la asociación de IL-12 con IL-2. Así, nos hemos propuesto el estudio de la capacidad de respuesta inmune antitumoral, tras la administración sistémica de IL-12 sola o combinada con IL-2, en un modelo experimental de CCR inducidos mediante la administración de 1,2-dimetilhidracina (DMH. Método: sesenta y cinco ratas Wistar de 6 semanas a las que se administró en inyección subcutánea una dosis semanal de DMH a razón de 20 mg/kg de peso durante 26 semanas. Finalizado el periodo de inducción, los animales se distribuyeron aleatoriamente en tres grupos. I: grupo control. Grupo II, se administró IL-12 recombinante murina. Grupo III: se administró IL-12, combinada con IL-2. Las ratas se sacrificaron en la semana 30, estudiándose los siguientes parámetros: número y localización de tumores, tamaño y carga tumoral. Se realiz

Management Educativo y Desempeño Docente en la Ugel N° 12 – Provincia de Canta

OpenAIRE

Napan Yactayo, Ana Cecilia

2016-01-01

El objetivo general de la presente investigación fue: Determinar la relación del management educativo con el desempeño docente en la Ugel 12 de la provincia de Canta. Y la hipótesis: el Management educativo se relaciona significativamente con el desempeño docente de la Ugel N° 12 de la provincia de Canta. El tipo de investigación fue aplicada y nivel explicativo. Se trabajó con un diseño no probabilístico, con una población de 202 docentes, tomando una muestra no probabilíst...

Solid electrolytes. Extremely fast charge carriers in garnet-type Li{sub 6}La{sub 3}ZrTaO{sub 12} single crystals

Energy Technology Data Exchange (ETDEWEB)

Stanje, Bernhard; Breuer, Stefan; Uitz, Marlena [Christian Doppler Laboratory for Lithium Batteries, and Institute for Chemistry and Technology of Materials, Graz University of Technology (NAWI Graz), Graz (Austria); DFG Research Unit ' ' Mobility of Lithium Ions in Solids' ' , Graz University of Technology, Graz (Austria); Rettenwander, Daniel; Redhammer, Guenther [Department Chemistry and Physics of Materials, University of Salzburg (Austria); Berendts, Stefan; Lerch, Martin [Technische Universitaet Berlin, Institut fuer Chemie (Germany); Uecker, Reinhard [Leibniz Institute for Crystal Growth (Forschungsverbund Berlin e.V.), Berlin (Germany); Hanzu, Ilie; Wilkening, Martin [Christian Doppler Laboratory for Lithium Batteries, and Institute for Chemistry and Technology of Materials, Graz University of Technology (NAWI Graz), Graz (Austria); DFG Research Unit ' ' Mobility of Lithium Ions in Solids' ' , Graz University of Technology, Graz (Austria); Alistore-ERI European Research Institute, Amiens (France)

2017-12-15

The development of all-solid-state electrochemical energy storage systems, such as lithium-ion batteries with solid electrolytes, requires stable, electronically insulating compounds with exceptionally high ionic conductivities. Considering ceramic oxides, garnet-type Li{sub 7}La{sub 3}Zr{sub 2}O{sub 12} and derivatives, see Zr-exchanged Li{sub 6}La{sub 3}ZrTaO{sub 12} (LLZTO), have attracted great attention due to its high Li{sup +} ionic conductivity of 10{sup -3} S cm{sup -1} at ambient temperature. Despite numerous studies focussing on conductivities of powder samples, only few use time-domain NMR methods to probe Li ion diffusion parameters in single crystals. Here we report on temperature-variable NMR relaxometry measurements using both laboratory and spin-lock techniques to probe Li jump rates covering a dynamic time window spanning several decades. Both techniques revealed a consistent picture of correlated Li ion jump diffusion in the single crystal; the data perfectly mirror a modified BPP-type relaxation response being based on a Lorentzian-shaped relaxation function. The rates measured could be parameterized with a single set of diffusion parameters. Results from NMR are completely in line with ion transport parameters derived from conductivity spectroscopy. (copyright 2017 by WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

Algoritmo para el cálculo de la transformada Z inversa utilizando DERIVE // Algorithm for the calculation of the transformed inverse Z using the mathematical assistant DERIVE.

Directory of Open Access Journals (Sweden)

D. Galán Martínez

2000-07-01

Full Text Available Una de las herramientas matemáticas más utilizadas en ingeniería en el estudio de los denominados sistemas de control dedatos muestreados es la transformada Z. La transformada Z como método operacional puede ser utilizada en la resoluciónde ecuaciones en diferencias finitas; las cuales formulan la dinámica de los sistemas de control de datos muestreados. Estatransformada juega un papel similar que el de la transformada de Laplace en el análisis de los sistemas de control de tiempocontinuo.El presente trabajo tiene como objetivo la confección de un programa para computadora digital, utilizando el asistentematemático DERIVE, para la determinación de la transformada Z inversa de una función algebraica racional, las cualesmodelan matemáticamente los sistemas de control de datos muestreados lineales que aparecen con mucha frecuencia en elestudio de los procesos de ingeniería.Palabras claves: Algoritmo, transformada Z, DERIVE, función algebraica racional, modelo matemático._______________________________________________________________________AbstractOne of the mathematical tools more used in engineering in the study of the denominated systems of data control samples isthe transformed Z. The transformed Z like as an operational method can be used in the resolution of equations in finitedifferences; which formulate the dynamics of the systems of data control samples. This transformed plays a similar paperthat the Laplace transformed in the analysis of the systems of control in continuous time.The present work has as objective the confection of a program for digital computer, using the mathematical assistantDERIVES, for the determination of the Z inverse transformed of a rational algebraic function, which model mathematicallythe systems of lineal data control samples that appear very frecuently in the study of the engineering processesKey words: algorithm, Z inverse transformed, Derives, Digital computer program, Rational

Preclinical studies on toxicity, antitumour activity and pharmacokinetics of cisplatin and three recently developed derivatives.

Science.gov (United States)

Lelieveld, P; Van der Vijgh, W J; Veldhuizen, R W; Van Velzen, D; Van Putten, L M; Atassi, G; Danguy, A

1984-08-01

Preclinical studies were performed in mice, rats and dogs of cis-diamminedichloroplatinum(II) (CDDP) and its derivatives cis-1,1-di(aminomethyl) cyclohexane platinum(II) sulphate (TNO-6), cis-diammine-1,1-cyclobutanedicarboxylate platinum(II) (CBDCA) and cis-dichloro, trans-dihydroxybis-isopropylamine platinum(IV) (CHIP). In mice toxicity and antitumour activity were determined. All three derivatives were at least as toxic as CDDP for haemopoietic stem cells and were less active than CDDP against the mouse tumours leukaemia L1210 and osteosarcoma C22LR. Toxicology studies in rats revealed no renal toxicity after a single dose of TNO-6. Fractionated doses of TNO-6 and CBDCA did cause renal toxicity but less than CDDP. CHIP produced little or no kidney damage. In dogs, TNO-6 (1.5 mg/kg) produced more severe kidney damage--although this was reversible--than CDDP (2 mg/kg). Half-lives of distribution were 4.0-5.1 min for TNO-6 and 9.7 min for CDDP, while half-lives of elimination were 3.6-6.6 days and 5.9 days respectively. Plasma levels, normalized for the dose, were at least two times higher after TNO-6 than after CDDP. Twelve weeks after drug administration, plasma levels were undetectable, while tissue concentrations could still be measured. The platinum concentration in kidney cortex was higher after CDDP than after TNO-6.

Effects of heating atmosphere on formation of crystalline citrate-derived LaAlO3 nanoparticles

International Nuclear Information System (INIS)

Yu, Hsuan-Fu; Guo, Yu-Man

2011-01-01

Research highlights: → LaAlO 3 can be crystallized at 550 deg. C in an oxygen-enriched atmosphere. → Calcining the citrate precursor in oxygen atmosphere lowers the reaction temperatures to form crystalline LaAlO 3 . → In oxygen atmosphere, pure citrate-derived LaAlO 3 nanoparticles can be produced at 700 deg. C. - Abstract: Crystalline LaAlO 3 nanoparticles were synthesized at relative low temperatures, using a citrate-precursor technique. La(NO 3 ) 3 , Al(NO 3 ) 3 , and C 3 H 4 (OH)(COOH) 3 , in a molar ratio of 1:1:1, were dissolved in deionized water. NH 4 OH was used to adjust the aqueous solution to pH 7. After drying, the citrate precursors were charred at 350 deg. C, followed by calcination at different temperatures, in air or oxygen atmosphere. The thermochemical properties of the resultant particles were analyzed using thermogravimetric and differential thermal analysis, X-ray diffractometry, infrared spectroscopy, scanning electron microscopy, and transmission electron microscopy. Effects of calcination temperature and heating atmosphere on the formation of crystalline LaAlO 3 nanoparticles were investigated. In O 2 atmosphere, clacining the citrate-derived charred solid precursor at 700 deg. C for 3 h can decompose all intermediates to produce pure LaAlO 3 nanoparticles (particle sizes ≤ 100 nm) with an average crystallite size of about 24 nm and possessing high sinterability.

Structural and dielectric characteristics of double perovskite La2(NiFe)1/2MnO6

Science.gov (United States)

Nasir, Mohd.; Kandasami, Asokan; Sen, Somaditya

2018-05-01

Recently, La2NiMnO6 has drawn significant interest because large magnetic field induced changes in dielectric properties makes this compound a promising material for potential spintronic device applications. In the present study, the structural and dielectric characteristics of sol-gel prepared La2(Ni1/2Fe1/2)MnO6 double perovskite ceramics were evaluated. La2(Ni1/2Fe1/2)MnO6 was crystallized in the monoclinic P21/n structure with ordered Ni2+/Fe2+ and Mn4+ cations. A giant dielectric constant with relaxor-like behavior was observed, which was attributed to the dipolar effects arising from hopping between Ni2+/Fe2+ and Mn4+ ions.

Novel 3-(aminomethyl)naphthoquinone mannich base-platinum(IV) complexes: synthesis, characterization, electrochemical and cytotoxic studies

International Nuclear Information System (INIS)

Silva, Gustavo B. da; Neves, Amanda P.; Vargas, Maria D.; Alves, Wagner A.; Marinho-Filho, Jose D.B.; Pessoa, Claudia; Moraes, Manoel O.; Costa-Lotufo, Leticia V.

2013-01-01

Three novel platinum(IV) complexes cis,cis,trans-[Pt(HL1-3)Cl 2 (OH) 2 ] 1b-3b(HL = 2-hydroxy-3-[(R 1 -amino)(pyridin-2-yl)methyl]-1,4-naphthoquinone, R 1 = n-butyl, HL1; n-heptyl, HL2 and n-decyl, HL3) have been obtained from the oxidation of the respective precursors cis-[Pt(HL1-3)Cl 2 ] 1a-3a. Cyclic voltammetry studies of 1b-3b in MeCN showed the quasi reversible naphthoquinonate (NQO - , i.e., L - ) redox process and irreversible process attributed to the reduction of the Pt 4+ /Pt 2+ pair, at potentials about 400 mV less negative than for the cisplatin precursor cis,cis,trans-[Pt(NH 3 ) 2 Cl 2 (OH) 2 ]. Hydrogen bond interaction between the naphthoquinone 2-hydroxyl group and an axially coordinated hydroxide ligand in 1b-3b has been proposed to favor the Pt 4+ /Pt 2+ reduction. The cytotoxicity studies against four human cancer cell lines have shown that in general the platinum(IV) and platinum(II)derivatives exhibit the same cytotoxic profile and are all more active than cisplatin. The lowest in vitro IC 50 values have been observed for 2b-3b, which bear ligands with the largest R 1 groups (HL2-HL3) being the most lipophilic. Furthermore similar IC 50 values for platinum(II) and platinum(IV) complexes of the same ligands have been associated with rapid in vitro reduction of the latter complexes to afford 1a-3a. (author)

Synthesis and fluorosolvatochromism of 3-arylnaphtho[1,2-b]quinolizinium derivatives

Directory of Open Access Journals (Sweden)

Phil M. Pithan

2016-05-01

Full Text Available Cationic biaryl derivatives were synthesized by Suzuki–Miyaura coupling of 3-bromonaphtho[1,2-b]quinolizinium bromide with arylboronic acids. The resulting cationic biaryl derivatives exhibit pronounced fluorosolvatochromic properties. First photophysical studies in different solvents showed that the emission energy of the biaryl derivatives decreases with increasing solvent polarity. This red-shifted emission in polar solvents is explained by a charge shift (CS in the excited state and subsequent solvent relaxation. Furthermore, the polarity of protic polar and aprotic polar solvents affects the emission energy to different extent, which indicates a major influence of hydrogen bonding on the stabilization of the ground and excited states.

Enthalpies of vaporization of some acetylene peroxy derivatives of carboranes-12

International Nuclear Information System (INIS)

Dibrivnyj, V.N.; Pistun, Z.E.; Van-Chin-Syan, Yu.Ya.; Yuvchenko, A.P.; Zvereva, T.D.

1999-01-01

Temperature dependences of saturated vapor pressure and vaporization enthalpies of five acetylene peroxy derivatives of carboranes-12 are determined by the Knudsen effusion method. Enthalpies and melting points of crystals, as well as temperatures of liquid compounds decomposition start are determined by the method of differential scanning calorimetry. Comparison of evaporation enthalpies determined in the study confirms the conclusions on non-additive character of intermolecular interaction in carboranes and their derivatives, which have been made previously [ru

Low-frequency dielectric dispersion and magnetic properties of La, Gd modified Pb(Fe1/2Ta1/2)O3 multiferroics

International Nuclear Information System (INIS)

Choudhury, R.N.P.; Rodriguez, C.; Bhattacharya, P.; Katiyar, R.S.; Rinaldi, C.

2007-01-01

Pb(Fe 1/2 Ta 1/2 )O 3 (PFT) modified by rare-earth (La and Gd) ions has been synthesized in a single phase using a double-stage synthesis (i.e., Columbite) technique. Scanning electron micrographs (SEM) of the pellet samples have shown a significant change in their grain size and uniform distribution of Gd/La at the Fe-sites. The room temperature X-ray structural analysis shows that the reported cubic (or tetragonal) structure of PFT has been distorted to a monoclinic system on substitution of La/Gd at the Fe-site. Detailed studies of dielectric properties of the above compound on La/Gd substitution have shown strong dielectric dispersion at low frequency (i.e. relaxor behavior) with drastic change in transition temperature. Magnetic characterization shows that though the PFT sample displays an antiferromagnetic transition at ∼150 K, the rare-earth ions-substituted samples do not. Furthermore, temperature dependence of magnetization measurements shows that spin glass transition observed in PFT at low temperatures (5-20 K) does not exist in the La and Gd substituted PFT. Doping of Gd in PFT increases the sample magnetization, especially at low temperature

Luminescence and excited state dynamics in Bi3+-doped LiLaP4O12 phosphates

International Nuclear Information System (INIS)

Babin, V.; Chernenko, K.; Demchenko, P.; Mihokova, E.; Nikl, M.; Pashuk, I.; Shalapska, T.; Voloshinovskii, A.; Zazubovich, S.

2016-01-01

Photo- and X-ray-excited luminescence characteristics of Bi-doped LiLaP 4 O 12 phosphates with different bismuth contents (from 1 to 25 at% in the melt) are investigated in the 4.2–300 K temperature range and compared with the characteristics of the undoped LiLaP 4 O 12 phosphate. The broad 2.95 eV emission band of LiLaP 4 O 12 :Bi excited around 5.4 eV is found to arise from the bismuth dopant. Relatively large FWHM and Stokes shift of the emission band and especially the data on the low-temperature decay kinetics of the 2.95 eV emission and its temperature dependence, indicating a very small spin-orbit splitting energy of the corresponding excited state, allow the conclusion that this emission arises from the radiative decay of the triplet state of an exciton localized around a Bi 3+ ion. No spectral bands are observed, arising from the electron transitions between the energy levels of Bi 3+ ions. Phenomenological model is proposed for the description of the excited state dynamics of the Bi 3+ -related localized exciton in LiLaP 4 O 12 :Bi and the parameters of the triplet localized exciton state are determined. Keywords: Photoluminescence; Time-resolved spectroscopy; Excited states; Bi 3+ centers; LiLaP 4 O 12 :Bi powders

Identification of two distinct chromosome 12-derived amplification units in neuroblastoma cell line NGP

NARCIS (Netherlands)

van Roy, N.; Forus, A.; Myklebost, O.; Cheng, N. C.; Versteeg, R.; Speleman, F.

1995-01-01

The neuroblastoma cell line NGP contains two homogeneously staining regions (hsr). One of these hsrs contains MYCN sequences. Reverse painting experiments demonstrated that the second HSR consisted of two chromosome 12-derived amplification units, located at 12q14-15 and 12q24. Southern blot and

Structure refinement, far infrared spectroscopy, and dielectric characterization of (1-x)La(Mg1/2Ti1/2)O3-xLa2/3TiO3 solid solutions

Science.gov (United States)

Salak, Andrei N.; Khalyavin, Dmitry D.; Ferreira, Victor M.; Ribeiro, José L.; Vieira, Luís G.

2006-05-01

Dielectric properties of (1-x)La(Mg1/2Ti1/2)O3-xLa2/3TiO3 [(1-x)LMT-xLT] ceramics (0infrared (FIR) frequency ranges. The crystal structure sequence in (1-x)LMT-xLT reported by different authors has been analyzed and revised. FIR spectroscopy was used to characterize the lattice contribution to the dielectric response at microwave frequencies. The complex dielectric function was evaluated from the reflectivity data and extrapolated down to a gigahertz range. Compositional variations of the fundamental microwave dielectric parameters estimated by different methods are compared and discussed. The dependence of the quality factor on the composition in LMT-LT is interpreted in terms of the reduction of spatial phonon correlations originated from the increasing amount of La vacancies. This approach could account for the compositional behavior of the dielectric loss commonly observed in a number of microwave mixed systems.

Li+ transport properties of W substituted Li7La3Zr2O12 cubic lithium garnets

Directory of Open Access Journals (Sweden)

L. Dhivya

2013-08-01

Full Text Available Lithium garnet Li7La3Zr2O12 (LLZ sintered at 1230 °C has received considerable importance in recent times as result of its high total (bulk + grain boundary ionic conductivity of 5 × 10−4 S cm−1 at room temperature. In this work we report Li+ transport process of Li7−2xLa3Zr2−xWxO12 (x = 0.3, 0.5 cubic lithium garnets. Among the investigated compounds, Li6.4La3Zr1.7W0.3O12 sintered relatively at lower temperature 1100 °C exhibits highest room temperature (30 °C total (bulk + grain boundary ionic conductivity of 7.89 × 10−4 S cm−1. The temperature dependencies of the bulk conductivity and relaxation frequency in the bulk are governed by the same activation energy. Scaling the conductivity spectra for both Li6.4La3Zr1.7W0.3O12 and Li6La3Zr1.5W0.5O12 sample at different temperatures merges on a single curve, which implies that the relaxation dynamics of charge carriers is independent of temperature. The shape of the imaginary part of the modulus spectra suggests that the relaxation processes are non-Debye in nature. The present studies supports the prediction of optimum Li+ concentration required for the highest room temperature Li+ conductivity in LixLa3M2O12 is around x = 6.4 ± 0.1.

Stress relaxation of La1/2Sr1/2MnO3 and La2/3Ca1/3MnO3 at solid oxide fuel cell interfaces

International Nuclear Information System (INIS)

Lussier, A.; Dvorak, J.; Stadler, S.; Holroyd, J.; Liberati, M.; Arenholz, E.; Ogale, S.B.; Wu, T.; Venkatesan, T.; Idzerda, Y.U.

2008-01-01

Interfacial stress is thought to have significant effects on electrical and oxygen transport properties in thin films of importance in solid oxide fuel cell applications. We investigate how in-plane biaxial stress modifies the electronic structure of La 2/3 Ca 1/3 MnO 3 and La 1/2 Sr 1/2 MnO 3 thin films prepared by pulsed laser deposition on three different substrates to vary the in-plane stress from tensile to compressive. The electronic structure was probed by X-ray absorption spectroscopy of the Mn L 2,3 -edge to characterize the interfacial disruption in this region in an element-specific, site-specific manner. The compressive or tensile interfacial strain modifies the relative concentrations of La and Sr in the interfacial region in order to achieve a better lattice match to the contact material. This atomic migration generates an interfacial region dominated by a compound with a single valency for the transition metal ion, resulting in a severe barrier to oxygen and electron transport through this region

RESPUESTA DE 12 VARIEDADES DE TRIGO A LA SALINIDAD EN LAS ETAPAS INICIALES DEL CRECIMIENTO

OpenAIRE

L. Argentel; L. M. González; R. Plana

2006-01-01

Con el objetivo de analizar la respuesta varietal del cultivo de trigo a la salinidad en las etapas iniciales del crecimiento de las plántulas, se montó un experimento con 12 variedades, aplicando dos niveles de NaCl en la solución. Las variables evaluadas fueron la absorción de agua por las semillas, altura de las plantas y longitud de la raíz, y la acumulación de biomasas fresca y seca. Mediante un análisis de componentes principales, se establecieron los indicadores de mayor contribución a...

Novel 3-(aminomethyl)naphthoquinone mannich base-platinum(IV) complexes: synthesis, characterization, electrochemical and cytotoxic studies

Energy Technology Data Exchange (ETDEWEB)

Silva, Gustavo B. da; Neves, Amanda P.; Vargas, Maria D., E-mail: mdvargas@vm.uff.br [Universidade Federal Fluminense (UFF), Niteroi, RJ (Brazil). Instituto de Quimica; Alves, Wagner A. [Universidade Federal Rural do Rio de Janeiro (UFRRJ), Seropedica, RJ (Brazil). Departamento de Quimica; Marinho-Filho, Jose D.B.; Pessoa, Claudia; Moraes, Manoel O.; Costa-Lotufo, Leticia V. [Universidade Federal do Ceara (UFCE), Fortaleza, CE (Brazil). Centro de Ciencias da Saude. Departamento de Fisiologia e Farmacologia

2013-04-15

Three novel platinum(IV) complexes cis,cis,trans-[Pt(HL1-3)Cl{sub 2}(OH){sub 2}] 1b-3b(HL = 2-hydroxy-3-[(R{sup 1} -amino)(pyridin-2-yl)methyl]-1,4-naphthoquinone, R{sup 1} = n-butyl, HL1; n-heptyl, HL2 and n-decyl, HL3) have been obtained from the oxidation of the respective precursors cis-[Pt(HL1-3)Cl{sub 2}] 1a-3a. Cyclic voltammetry studies of 1b-3b in MeCN showed the quasi reversible naphthoquinonate (NQO{sup -}, i.e., L{sup -}) redox process and irreversible process attributed to the reduction of the Pt{sup 4+}/Pt{sup 2+} pair, at potentials about 400 mV less negative than for the cisplatin precursor cis,cis,trans-[Pt(NH{sub 3}){sub 2}Cl{sub 2}(OH){sub 2}]. Hydrogen bond interaction between the naphthoquinone 2-hydroxyl group and an axially coordinated hydroxide ligand in 1b-3b has been proposed to favor the Pt{sup 4+}/Pt{sup 2+} reduction. The cytotoxicity studies against four human cancer cell lines have shown that in general the platinum(IV) and platinum(II)derivatives exhibit the same cytotoxic profile and are all more active than cisplatin. The lowest in vitro IC{sub 50} values have been observed for 2b-3b, which bear ligands with the largest R{sup 1} groups (HL2-HL3) being the most lipophilic. Furthermore similar IC{sub 50} values for platinum(II) and platinum(IV) complexes of the same ligands have been associated with rapid in vitro reduction of the latter complexes to afford 1a-3a. (author)

Efectos sobre los estados financieros de la aplicación de la norma internacional de contabilidad Nº 12 "Impuesto sobre la ganancias"

OpenAIRE

Giraldo Gómez, Carlos Mario

2014-01-01

El objetivo del presente trabajo: NIC 12 (Normas Internacionales de Contabilidad), “Impuesto a las ganancias e impuesto diferido”, parte integral de las NIIF (Normas Internacionales de Información Financiera), es identificar algunos aspectos especiales que se reflejarán en los estados financieros de las empresas en relación con el manejo del impuesto diferido -- Lo anterior originado en las diferencias que se darán al comparar la información contable con la información fiscal, y que de una ma...

The solubility and site preference of Fe3+ in Li7-3xFexLa3Zr2O12 garnets

Science.gov (United States)

Rettenwander, D.; Geiger, C. A.; Tribus, M.; Tropper, P.; Wagner, R.; Tippelt, G.; Lottermoser, W.; Amthauer, G.

2015-10-01

A series of Fe3+-bearing Li7La3Zr2O12 (LLZO) garnets was synthesized using solid-state synthesis methods. The synthetic products were characterized compositionally using electron microprobe analysis and inductively coupled plasma optical emission spectroscopy (ICP-OES) and structurally using X-ray powder diffraction and 57Fe Mössbauer spectroscopy. A maximum of about 0.25 Fe3+ pfu could be incorporated in Li7-3xFexLa3Zr2O12 garnet solid solutions. At Fe3+ concentrations lower than about 0.16 pfu, both tetragonal and cubic garnets were obtained in the synthesis experiments. X-ray powder diffraction analysis showed only a garnet phase for syntheses with starting materials having intended Fe3+ contents lower than 0.52 Fe3+ pfu. Back-scattered electron images made with an electron microprobe also showed no phase other than garnet for these compositions. The lattice parameter, a0, for all solid-solution garnets is similar with a value of a0≈12.98 Å regardless of the amount of Fe3+. 57Fe Mössbauer spectroscopic measurements indicate the presence of poorly- or nano-crystalline FeLaO3 in syntheses with Fe3+ contents greater than 0.16 Fe3+ pfu. The composition of different phase pure Li7-3xFexLa3Zr2O12 garnets, as determined by electron microprobe (Fe, La, Zr) and ICP-OES (Li) measurements, give Li6.89Fe0.03La3.05Zr2.01O12, Li6.66Fe0.06La3.06Zr2.01O12, Li6.54Fe0.12La3.01Zr1.98O12, and Li6.19Fe0.19La3.02Zr2.04O12. The 57Fe Mössbauer spectrum of cubic Li6.54Fe0.12La3.01Zr1.98O12 garnet indicates that most Fe3+ occurs at the special crystallographic 24d position, which is the standard tetrahedrally coordinated site in garnet. Fe3+ in smaller amounts occurs at a general 96h site, which is only present for certain Li-oxide garnets, and in Li6.54Fe0.12La3.01Zr1.98O12 this Fe3+ has a distorted 4-fold coordination.

Internal Friction of Li7La3Zr2O12 Based Lithium Ionic Conductors

Directory of Open Access Journals (Sweden)

Wang X.P.

2016-03-01

Full Text Available The diffusion mechanisms of lithium ions in tetragonal phase as well as in Al and Nb stabilized cubic Li7La3Zr2O12 compounds were investigated by low-frequency internal friction technique. In the cubic Li7La3Zr2O12 phase, a remarkable relaxation-type internal friction peak PC with a peak height up to 0.12 was observed in the temperature range from 15°C to 60°C. In the tetragonal phase however, the height of the PT peak dropped to 0.01. The obvious difference of the relaxation strength between the cubic and tetragonal phases is due to the different distribution of lithium ions in lattice, ordered in the tetragonal phase and disordered in the cubic phase. Based on the crystalline structure of the cubic garnet-type Li7La3Zr2O12 compound, it is suggested that the high internal friction peak in the cubic phase may be attributed to two diffusion processes of lithium ions: 96h↔96h and 96h↔24d.

Light-induced reduction of rhodium(III) and palladium(II) on titanium dioxide dispersions and the selective photochemical separation and recovery of gold(III), platinum(IV), and rhodium(III) in chloride media

Energy Technology Data Exchange (ETDEWEB)

Borgarello, E.; Serpone, N.; Emo, G.; Harris, R.; Pelizzetti, E.; Minero, C.

1986-12-03

Irradiation of aqueous TiO/sub 2/ dispersions containing palladium(II) or rhodium(III) chloride salts with AM1 simulated sunlight leads to the photoreduction of these metals, which are deposited on the semiconductor particle surface. Oxygen is detrimental to the photoreduction of rhodium(III) but not the photoreduction of palladium(II). However, in both cases the reduction process is most efficient if the solution contains CH/sub 3/OH, which acts to scavenge valence band holes of the illuminated TiO/sub 2/ semiconductor. The selective photoreduction and recovery of precious metals from a dilute solution (as might be found in industrial wastes) have been investigated for a mixture of gold(III), platinum(IV), and rhodium(III) chloride salts as a function of various parameters (pH, presence or absence of O/sub 2/, presence or absence of a hole scavenger, and the concentration of the semiconductor). At pH 0, gold is easily separated from platinum and rhodium. The rate of photoreduction of gold(III) on TiO/sub 2/ is nearly independent of the concentration of the semiconductor, under the experimental conditions employed; the limiting rate is 2.7 x 10/sup -7/ M s/sup -1/. The potential utility of this selective photochemical technique is discussed.

Derivation of orthogonal leads from the 12-lead electrocardiogram. Performance of an atrial-based transform for the derivation of P loops.

Science.gov (United States)

Guillem, M Salud; Sahakian, Alan V; Swiryn, Steven

2008-01-01

The objective of this study was the evaluation of the accuracy of Dower inverse transform for the derivation of the P wave in orthogonal leads. We tested the accuracy of Dower transform on the P wave and compared it with a P-wave-optimized transform in a database of 123 simultaneous recordings of electrocardiograms and vectorcardiograms. This new transform achieved a lower error when we compared derived vs true measured P waves (mean +/- SD, 12.2 +/- 8.0 VRMS) than Dower transform (14.4 +/- 9.5 Root mean squared voltage) and higher correlation values (Rx, 0.93 +/- 0.12; Ry, 0.90 +/- 0.27; Rz, 0.91 +/- 0.18; vs Dower: Rx, 0.88 +/- 0.15; Ry, 0.91 +/- 0.26; Rz, 0.85 +/- 0.23). We conclude that derivation of orthogonal leads for the P wave can be improved by using an atrial-based transform matrix.

12 CFR 956.5 - Authorization for derivative contracts and other transactions.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Authorization for derivative contracts and other transactions. 956.5 Section 956.5 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOME LOAN BANK ASSETS AND OFF-BALANCE SHEET ITEMS FEDERAL HOME LOAN BANK INVESTMENTS § 956.5 Authorization...

Investigation on thermophysical properties of RE{sub 6}UO{sub 12}(s) (RE = La, Pr, Nd, Sm)

Energy Technology Data Exchange (ETDEWEB)

Sahu, Manjulata, E-mail: manju@barc.gov.in [Radioanalytical Chemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085 (India); Krishnan, K. [Fuel Chemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085 (India); Jain, Dheeraj [Chemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085 (India); Saxena, M.K. [Radioanalytical Chemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085 (India); Dash, Smruti [Product development Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085 (India)

2016-08-10

Highlights: • Synthesis of RE{sub 6}UO{sub 12}(s)(RE = La, Pr, Nd, Sm) was performed by combustion method and characterization by XRD. • Thermal expansion measurements were carried out on RE{sub 6}UO{sub 12}(s)(RE = Pr, and Sm) using HT-XRD. • Heat capacity of RE{sub 6}UO{sub 12}(s)(RE = La, Pr, Nd, Sm) was measured in the temperature range 300–870 K. • The nonstoichiometry in RE{sub 6}UO{sub 12}(s) was checked using TG, XPS, chemical analysis and electrical conductivity measurement. - Abstract: RE{sub 6}UO{sub 12}(s) (RE = La, Pr, Nd, Sm) was synthesized by citrate-nitrate combustion method. The synthesis condition for Pr{sub 6}UO{sub 12}(s) was optimized. Nonstoichiometry in these rare earth uranates in argon atmosphere was analysed using various techniques like thermogravimetry (TG), X-ray photo electron spectroscopy (XPS), chemical analysis and electrical conductivity measurements. Thermal expansions of RE{sub 6}UO{sub 12}(s) (RE = Pr and Sm) was studied in the temperature range 298–1273 K by high temperature X-ray powder diffractometry and compared with that of similar rare earth compounds reported in the literature. Heat capacity of RE{sub 6}UO{sub 12}(s) (RE = La, Pr, Nd, Sm) was measured by differential scanning calorimetry in the temperature range 300–870 K. Enthalpy, entropy and Gibbs energy functions of these compounds were computed from the measured heat capacity data.

Platinum(IV) complex LA-12 induces cell cycle phase specific apoptosis in colon carcinoma cell line HCT-116

Czech Academy of Sciences Publication Activity Database

Vondálová Blanářová, Olga; Jelínková, Iva; Jendželovský, R.; Souček, Karel; Hofmanová, Jiřina; Sova, P.; Kozubík, Alois

2009-01-01

Roč. 276, č. 1 (2009), s. 256-257 ISSN 1742-464X. [34th FEBS Congress. 04.07.2009-09.07.2009, Prague] R&D Projects: GA AV ČR(CZ) 1QS500040507; GA ČR(CZ) GA301/07/1557 Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702 Keywords : platinum drugs * cell cycle apoptosis Subject RIV: BO - Biophysics

Fibroblast-derived CXCL12 promotes breast cancer metastasis by facilitating tumor cell intravasation.

Science.gov (United States)

Ahirwar, Dinesh K; Nasser, Mohd W; Ouseph, Madhu M; Elbaz, Mohamad; Cuitiño, Maria C; Kladney, Raleigh D; Varikuti, Sanjay; Kaul, Kirti; Satoskar, Abhay R; Ramaswamy, Bhuvaneswari; Zhang, Xiaoli; Ostrowski, Michael C; Leone, Gustavo; Ganju, Ramesh K

2018-05-03

The chemokine CXCL12 has been shown to regulate breast tumor growth, however, its mechanism in initiating distant metastasis is not well understood. Here, we generated a novel conditional allele of Cxcl12 in mice and used a fibroblast-specific Cre transgene along with various mammary tumor models to evaluate CXCL12 function in the breast cancer metastasis. Ablation of CXCL12 in stromal fibroblasts of mice significantly delayed the time to tumor onset and inhibited distant metastasis in different mouse models. Elucidation of mechanisms using in vitro and in vivo model systems revealed that CXCL12 enhances tumor cell intravasation by increasing vascular permeability and expansion of a leaky tumor vasculature. Furthermore, our studies revealed CXCL12 enhances permeability by recruiting endothelial precursor cells and decreasing endothelial tight junction and adherence junction proteins. High expression of stromal CXCL12 in large cohort of breast cancer patients was directly correlated to blood vessel density and inversely correlated to recurrence and overall patient survival. In addition, our analysis revealed that stromal CXCL12 levels in combination with number of CD31+ blood vessels confers poorer patient survival compared to individual protein level. However, no correlation was observed between epithelial CXCL12 and patient survival or blood vessel density. Our findings describe the novel interactions between fibroblasts-derived CXCL12 and endothelial cells in facilitating tumor cell intrvasation, leading to distant metastasis. Overall, our studies indicate that cross-talk between fibroblast-derived CXCL12 and endothelial cells could be used as novel biomarker and strategy for developing tumor microenvironment based therapies against aggressive and metastatic breast cancer.

Hexagonal perovskites with cationic vacancies. 19. The rhombohedral 12 L stacking polytypes Ba/sub 3/LaBsup(III) (W/sub 2/sup(VI)vacantO/sub 12/)

Energy Technology Data Exchange (ETDEWEB)

Rother, H J; Kemmler-Sack, S [Tuebingen Univ. (Germany, F.R.). Lehrstuhl fuer Anorganische Chemie 2

1980-06-01

Hexagonal perovskites are described for the new type Ba/sub 3/LaBsup(III)(W/sub 2/sup(VI)vacantO/sub 12/) with Bsup(III) = Sc, In, Lu, Yb. According to the intensity calculations for Ba/sub 3/LaIn(W/sub 2/vacantO/sub 12/) they crystallize in a rhombohedral 12 L structure with the sequence (3)(1) respectively (hhcc)/sub 3/; space group R3m. The refined, intensity related R' value is 6.7%.

Valores de referencia de la población diabética para la versión española del SF-12v2 Reference values of the Spanish version of the SF-12v2 for the diabetic population

Directory of Open Access Journals (Sweden)

Olga Monteagudo Piqueras

2009-12-01

Full Text Available Objetivo: Los cuestionarios de salud percibida son instrumentos que proporcionan información importante para la investigación en resultados de salud. La familia de cuestionarios SF requiere valores de referencia para interpretar el impacto en calidad de vida relacionada con la salud. Estudios previos han proporcionado estos valores para la población general española, pero no para condiciones específicas de enfermedad. El objetivo de este trabajo ha sido obtener, para la versión española del SF-12v2, los valores de referencia de la población diabética de la Región de Murcia. Métodos: Estudio transversal con encuesta telefónica a 1.500 personas representativas de los diabéticos tipo 1 y 2, no institucionalizados, de 18 años y más, de la Región de Murcia. Se calcularon medidas de tendencia central, dispersión y percentiles de las ocho dimensiones, e índices resumen (físico y mental, del SF-12v2. Resultados: El índice de salud mental (ISM medio (50,5±12,8 fue superior al físico (ISF (42,5±11,8. En función del sexo, los hombres obtuvieron un ISM (53,6±11,6 y un ISF (44,9±11,2 mejores que las mujeres (ISM: 47,7±13,2; ISF: 40,3±11,9. La dimensión mejor valorada fue la vitalidad (hombres: 57,2±11,1; mujeres: 51,9±12,1, y la peor la salud general (hombres: 39,0±9,7; mujeres: 35,8±10,0. Estratificando por grupos de edad, los hombres seguían presentando mejores puntuaciones que las mujeres. Conclusiones: Estos resultados deben ser considerados como valores de referencia de la población diabética de la Región de Murcia de la versión española del SF-12v2, y pueden ser útiles para establecer objetivos terapéuticos, comparar con población general, sana y con otras enfermedades.Objective: Perceived health status questionnaires provide important information for health outcomes research. Reference measures are required to interpret the health-related quality of life questionnaires belonging to the short form (SF health

Synthesis and superstructure of La sub(2/3) (Mg sub(1/2)W sub(1/2))O/sub 3/

Energy Technology Data Exchange (ETDEWEB)

Torii, Y [Government Industrial Research Inst., Nagoya (Japan)

1979-10-01

A new perovskite La sub(2/3)(Mg sub(1/2)W sub(1/2))O/sub 3/ having an orthorhombic multiple-cell was synthesized. The lattice constants were a = 7.8157(5) A, b = 7.8344(6) A and c = 2 x 7.9067(6) A. The superstructure was found to be due to a NaCl-type ordering of B ions as well as an ordering of A-site vacancies.

Multiferroicity in La1/2Nd1/2FeO3 nanoparticles

Science.gov (United States)

Chanda, Sadhan; Saha, Sujoy; Dutta, Alo; Mahapatra, A. S.; Chakrabarti, P. K.; Kumar, Uday; Sinha, T. P.

2014-11-01

Nano-sized La1/2Nd1/2FeO3 (LNF) powder is synthesized by the sol-gel citrate method. The Rietveld refinement of the X-ray diffraction profile of the sample at room temperature (303 K) shows the orthorhombic phase with Pbnm symmetry. The particle size is obtained by transmission electron microscope. The antiferromagnetic nature of the sample is explained using zero field cooled and field cooled magnetisation and the corresponding hysteresis loop. A signature of weak ferromagnetic phase is observed in LNF at low temperature which is explained on the basis of spin glass like behaviour of surface spins. The dielectric relaxation of the sample has been investigated using impedance spectroscopy in the frequency range from 42 Hz to 1 MHz and in the temperature range from 303 K to 513 K. The Cole-Cole model is used to analyse the dielectric relaxation of LNF. The frequency dependent conductivity spectra follow the power law. The magneto capacitance measurement of the sample confirms its multiferroic behaviour.

[Baicalein promotes the apoptosis of HeLa cells by inhibiting ERK1/2 expression].

Science.gov (United States)

Wang, Yongzhou; Xia, Jiyi; Tang, Xiaoping; Tang, Li; Mao, Xiguang; Zhang, Yujiao; Yu, Xiaolan

2016-11-01

Objective To investigate the effects of baicalein and U0126 treatment on the apoptosis of human cervical carcinoma HeLa cells and the potential mechanism. Methods HeLa cells were subjected to (1, 2, 5, 10, 20, 50, 100, 200, 300) μmol/L baicalein or (1, 2, 5, 10, 20, 30) μmol/L U0126 treatment for 24 hours. The optimal concentrations of baicalein and U0126 for HeLa inhibition was determined by a cell counting Kit-8 assay. HeLa cells were then treated with these inhibitory concentrations for 24 hours separately or in combination. The cell cycle and the degree of apoptosis were analyzed by flow cytometry. The cell apoptosis index was evaluated by the TUNEL assay. The expressions of extracellular signal-regulated kinase 1/2 (ERK1/2), Bax, and Bcl-2 at the mRNA and protein levels were examined by real-time PCR and Western blotting, respectively. Results Optimal inhibitory concentrations of baicalein and U0126 for HeLa cells were 200 μmol/L and 10 μmol/L, respectively. Compared with the control group, baicalein treatment increased the growth rate of cells in the G0/G1 phase but decreased the S phase. Combination treatment of 200 μmol/L baicalein and 10 μmol/L U0126 for 24 hours further reduced the S phase growth rate. Treatment with 10 μmol/L U0126 or 200 μmol/L baicalein for 24 hours induced cell apoptosis, and the combination treatment induced more apoptosis. Treatment by baicalein alone or in combination with U0126 for 24 hours significantly decreased ERK1/2 and Bcl-2 mRNA expressions, and upregulated Bax mRNA expression. It also downregulated ERK1/2 phosphorylation and Bcl-2 protein expression, while increasing Bax protein expression. Conclusion Both baicalein and U012 appear to inhibit proliferation, induce apoptosis, and increase the growth rate in the G0/G1 phase but reduce the S phase of HeLa cells. This effect is enhanced when they are used synergistically.

17 CFR 240.36a1-2 - Exemption from SIPA for OTC derivatives dealers.

Science.gov (United States)

2010-04-01

... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Exemption from SIPA for OTC derivatives dealers. 240.36a1-2 Section 240.36a1-2 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) GENERAL RULES AND REGULATIONS, SECURITIES EXCHANGE ACT OF 1934 Rules and Regulations...

Normas poblacionales de referencia de la versión española del SF-12V2 para la Región de Murcia Population based norms of the Spanish version of the SF-12V2 for Murcia (Spain

Directory of Open Access Journals (Sweden)

Olga Monteagudo Piqueras

2011-02-01

Full Text Available Objetivo: Los cuestionarios de salud percibida proporcionan información sobre resultados de salud. La valoración de su impacto requiere disponer de valores de referencia. En la población española, los estudios previos los han proporcionado para el SF-12v1. El objetivo fue obtener, para la versión española del SF-12v2, las normas poblacionales de referencia de la Región de Murcia. Métodos: Estudio transversal con encuesta telefónica a 3.486 personas no institucionalizadas de 18 años o más de edad, de la Región de Murcia. Se calcularon medidas de tendencia central, dispersión y percentiles de las dimensiones, y componentes sumario físico y mental (CSF y CSM del SF-12v2. Para la evaluación de constructo se compararon diferencias de medias en grupos conocidos (prueba t de Student o ANOVA. Resultados: Participaron en el estudio 3.381 sujetos. El 50,5% eran hombres, con una media de 43,6 años de edad, y de 46,0 en las mujeres. El CSF medio fue 48,6 (±10,6 y el CSM fue 53,6 (±10,7, y estas puntuaciones fueron superiores (mejores en los hombres, los grupos de edad más joven, las personas con estudios superiores y aquellas sin ninguna condición médica crónica (p=0,000. Los hombres presentaron mejores puntuaciones que las mujeres en la mayoría de las dimensiones y componentes sumario. La dimensión peor valorada por hombres y mujeres fue la salud general y el CSF. Conclusiones: Estos resultados, aunque deben considerarse como normas poblacionales de referencia de la versión española del SF-12v2 para la Región de Murcia, pueden ser utilizados por poblaciones similares a la hora de establecer objetivos de salud.Objective: Questionnaires on perceived health provide information on health results. Reference values are needed to assess these results. Previous studies have provided Spanish population-based norms for the SF-12v1. The aim of this study was to obtain the population-based norms for the Spanish version of the SF-12v2 for

New ferrocenic pyrrolo[1,2-a]quinoxaline derivatives: synthesis, and in vitro antimalarial activity.

Science.gov (United States)

Guillon, Jean; Moreau, Stéphane; Mouray, Elisabeth; Sinou, Véronique; Forfar, Isabelle; Fabre, Solene Belisle; Desplat, Vanessa; Millet, Pascal; Parzy, Daniel; Jarry, Christian; Grellier, Philippe

2008-10-15

Following our search for antimalarial compounds, novel series of ferrocenic pyrrolo[1,2-a]quinoxaline derivatives 1-2 were synthesized from various substituted nitroanilines and tested for in vitro activity upon the erythrocytic development of Plasmodiumfalciparum strains with different chloroquine-resistance status. The pyrrolo[1,2-a]quinoxalines 1 were prepared in 6-8 steps through a regioselective palladium-catalyzed monoamination by coupling 4-chloropyrrolo[1,2-a]quinoxalines with 1,3-bis(aminopropyl)piperazine or -methylamine using Xantphos as the ligand. The ferrocenic bispyrrolo[1,2-a]quinoxalines 2 were prepared by reductive amination of previously described bispyrrolo[1,2-a]quinoxalines 9 with ferrocene-carboxaldehyde, by treatment with NaHB(OAc)(3). The best results were observed with ferrocenic pyrrolo[1,2-a]quinoxalines linked by a bis(3-aminopropyl)piperazine. Moreover, it was observed that a methoxy group on the pyrrolo[1,2-a]quinoxaline nucleus and no substitution on the terminal N-ferrocenylmethylamine function enhanced the pharmacological activity. Selected compounds 1b, 1f-h, 1l and 2a were tested for their ability to inhibit beta-haematin formation, the synthetic equivalent of hemozoin, by using the HPIA (heme polymerization inhibitory activity) assay. Of the tested compounds, only 2a showed a beta-haematin formation inhibition, but no inhibition of haem polymerization was observed with the other selected ferrocenic monopyrrolo[1,2-a]quinoxaline derivatives 1b, 1f-h and 1l, as the IC(50) values were superior to 10 equivalents.

Observation of Vacancies, Faults, and Superstructures in Ln5Mo2O12 (Ln = La, Y, and Lu) Compounds with Direct Mo-Mo Bonding.

Science.gov (United States)

Colabello, Diane M; Sobalvarro, Elizabeth M; Sheckelton, John P; Neuefeind, Joerg C; McQueen, Tyrel M; Khalifah, Peter G

2017-11-06

Among oxide compounds with direct metal-metal bonding, the Y 5 Mo 2 O 12 (A 5 B 2 O 12 ) structural family of compounds has a particularly intriguing low-dimensional structure due to the presence of bioctahedral B 2 O 10 dimers arranged in one-dimensional edge-sharing chains along the direction of the metal-metal bonds. Furthermore, these compounds can have a local magnetic moment due to the noninteger oxidation state (+4.5) of the transition metal, in contrast to the conspicuous lack of a local moment that is commonly observed when oxide compounds with direct metal-metal bonding have integer oxidation states resulting from the lifting of orbital degeneracy typically induced by the metal-metal bonding. Although a monoclinic C2/m structure has been previously proposed for Ln 5 Mo 2 O 12 (Ln = La-Lu and Y) members of this family based on prior single crystal diffraction data, it is found that this structural model misses many important structural features. On the basis of synchrotron powder diffraction data, it is shown that the C2/m monoclinic unit cell represents a superstructure relative to a previously unrecognized orthorhombic Immm subcell and that the superstructure derives from the ordering of interchangeable Mo 2 O 10 and LaO 6 building blocks. The superstructure for this reason is typically highly faulted, as evidenced by the increased breadth of superstructure diffraction peaks associated with a coherence length of 1-2 nm in the c* direction. Finally, it is shown that oxygen vacancies can occur when Ln = La, producing an oxygen deficient stoichiometry of La 5 Mo 2 O 11.55 and an approximately 10-fold reduction in the number of unpaired electrons due to the reduction of the average Mo valence from +4.5 to +4.05, a result confirmed by magnetic susceptibility measurements. This represents the first observation of oxygen vacancies in this family of compounds and provides an important means of continuously tuning the magnetic interactions within the one

Ferroelectric properties of sandwich structured (Bi, La)4T3O12/Pb(Zr, Ti)O3/ (Bi, La)4Ti3O12 thin films on Pt/Ti/SiO2/Si substrates

International Nuclear Information System (INIS)

Bao Dinghua; Wakiya, Naoki; Shinozaki, Kazuo; Mizutani, Nobuyasu

2002-01-01

Sandwich structured (Bi, La) 4 Ti 3 O 12 /Pb(Zr, Ti)O 3 /(Bi, La) 4 Ti 3 O 12 thin films were fabricated on Pt/Ti/SiO 2 /Si substrates, with the intention of simultaneously utilizing the advantages of both (Bi, La) 4 Ti 3 O 12 (BLT) and Pb(Zr, Ti)O 3 (PZT) thin films such as non-fatigue behaviours of BLT and good ferroelectric properties of PZT. Both BLT and PZT layers were prepared by a chemical solution deposition technique. The experiments demonstrated that the sandwich structure showed fatigue-free characteristics at least up to 10 10 switching bipolar pulse cycles under 8 V and excellent retention properties. The sandwich structured thin films also exhibited well-defined hysteresis loops with a remanent polarization (2P r ) of 8.8 μC cm -2 and a coercive field (E c ) of 47 kV cm -1 . The room-temperature dielectric constant and dissipation factor were 210 and 0.031, respectively, at a frequency of 100 kHz. These results suggest that this sandwich structure is a promising material combination for ferroelectric memory applications. (author)

Expresión y purificación del preS1/2 del virus de la hepatitis B (VHB y su utilidad en el diagnóstico de la infección

Directory of Open Access Journals (Sweden)

Yismelvy Marquez

2013-12-01

Full Text Available La hepatitis B es una enfermedad inflamatoria del tejido hepático causada por la infección crónica del virus de la hepatitis B (VHB. Su diagnostico se basa en la detección de anticuerpos y antígenos contra dos de sus principales proteínas inmunogenicas, el antígeno de superficie (HBsAg y el del core (HBcAg. Existen otros dos componentes de la envoltura altamente inmunogenicos el preS1/2, sin embargo su papel en la evaluación de la respuesta serológica aún no ha sido evaluado. Es por ello que en este trabajo se propone expresar y purificar el preS1/2 usando a la Escherichia coli como sistema de expresión por ser el menos costoso a fin de obtener una proteína con propiedades antigénicas adecuadas para su utilización en el diagnostico serológico y evaluación de la respuesta inmune. El preS1/2 previamente clonado en el vector pET3d-preS1/2 se utilizó para transformar a la cepa de Escherichia coli (HMS174 y después de inducir la síntesis proteica mediante el uso de IPTG, se purifico mediante columna de afinidad al níquel, posteriormente analizadas en gel de electroforesis poliacrilamida, para seleccionar las fracciones de preS1/2. Después de dializarlas y liofilizarlas se logró obtener 5,4 mg/ml de la proteína pura, confirmado mediante la realización del western blott con un anticuerpo monoclonal específico. Estos resultados indican que este método es fácil, poco costoso y rápido para obtener una proteína pura con potencial uso en el diagnostico serológico de la infección por VHB.

La receta Penal Después de la llegada de la Ley N ° 12.234 / 10 , y su relación con las funciones de protección del Estado

Directory of Open Access Journals (Sweden)

Anelise Coelho Nunes

2016-06-01

Full Text Available Los cambios introducidos por la promulgación de la Ley n° 12.234 /10 trajeron una cierta controversia con respecto a una posible prescripción de la extinción (en forma retroactivo. En este sentido, el texto permite establecer un parámetro de la discusión, con la garantía de que el legislador optó por dar efecto ex tunc a la prescripción de la pretensión punitiva, en base a la sanción específica, sólo desde la recepción de la queja o reclamación. Por lo tanto, este estudio es necesario para tratar sobre el deber fundamental de la protección del Estado, que, por ley, acto administrativo o acciones de hecho, está obligado a actuar positivamente para evitar prácticas aceras sean perjudiciales para los derechos fundamentales.

Derivation of the clinical grade human embryonic stem cell line RCe016-A (RC-12

Directory of Open Access Journals (Sweden)

P.A. De Sousa

2016-05-01

Full Text Available The human embryonic stem cell line RCe016-A (RC-12 was derived under quality assured compliance with UK regulations, EU Directives and International guidance for tissue procurement, processing and storage according to good manufacturing practice (GMP standards. The cell line was derived from a cryopreserved blastocyst stage embryo voluntarily donated as surplus to fertility requirements following informed consent. RCe016-A (RC-12 shows normal pluripotency marker expression and differentiation to three germ layers in vitro. Karyology revealed a mixed male karyotype at early passage (P15, which resolved as normal 46XY by passage 33. Microsatellite PCR identity, HLA and blood group typing data is available.

17 CFR 240.3a12-7 - Exemption for certain derivative securities traded otherwise than on a national securities exchange.

Science.gov (United States)

2010-04-01

... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Exemption for certain derivative securities traded otherwise than on a national securities exchange. 240.3a12-7 Section 240.3a12-7... Miscellaneous Exemptions § 240.3a12-7 Exemption for certain derivative securities traded otherwise than on a...

The solubility and site preference of Fe3+ in Li7−3xFexLa3Zr2O12 garnets

International Nuclear Information System (INIS)

Rettenwander, D.; Geiger, C.A.; Tribus, M.; Tropper, P.; Wagner, R.; Tippelt, G.; Lottermoser, W.; Amthauer, G.

2015-01-01

A series of Fe 3+ -bearing Li 7 La 3 Zr 2 O 12 (LLZO) garnets was synthesized using solid-state synthesis methods. The synthetic products were characterized compositionally using electron microprobe analysis and inductively coupled plasma optical emission spectroscopy (ICP-OES) and structurally using X-ray powder diffraction and 57 Fe Mössbauer spectroscopy. A maximum of about 0.25 Fe 3+ pfu could be incorporated in Li 7−3x Fe x La 3 Zr 2 O 12 garnet solid solutions. At Fe 3+ concentrations lower than about 0.16 pfu, both tetragonal and cubic garnets were obtained in the synthesis experiments. X-ray powder diffraction analysis showed only a garnet phase for syntheses with starting materials having intended Fe 3+ contents lower than 0.52 Fe 3+ pfu. Back-scattered electron images made with an electron microprobe also showed no phase other than garnet for these compositions. The lattice parameter, a 0 , for all solid-solution garnets is similar with a value of a 0 ≈12.98 Å regardless of the amount of Fe 3+ . 57 Fe Mössbauer spectroscopic measurements indicate the presence of poorly- or nano-crystalline FeLaO 3 in syntheses with Fe 3+ contents greater than 0.16 Fe 3+ pfu. The composition of different phase pure Li 7−3x Fe x La 3 Zr 2 O 12 garnets, as determined by electron microprobe (Fe, La, Zr) and ICP-OES (Li) measurements, give Li 6.89 Fe 0.03 La 3.05 Zr 2.01 O 12 , Li 6.66 Fe 0.06 La 3.06 Zr 2.01 O 12 , Li 6.54 Fe 0.12 La 3.01 Zr 1.98 O 12 , and Li 6.19 Fe 0.19 La 3.02 Zr 2.04 O 12 . The 57 Fe Mössbauer spectrum of cubic Li 6.54 Fe 0.12 La 3.01 Zr 1.98 O 12 garnet indicates that most Fe 3+ occurs at the special crystallographic 24d position, which is the standard tetrahedrally coordinated site in garnet. Fe 3+ in smaller amounts occurs at a general 96h site, which is only present for certain Li-oxide garnets, and in Li 6.54 Fe 0.12 La 3.01 Zr 1.98 O 12 this Fe 3+ has a distorted 4-fold coordination. - Graphical abstract: Cubic nominally Li 7 La 3 Zr 2 O

Mechanism of derivation of radioresistance in HeLa cell population after repeated x-irradiation

International Nuclear Information System (INIS)

Kubo, Kihei; Koiwai, Soichiro; Morita, Kazuo

1982-01-01

The Radioresistant strain (X-8-5) was obtained from HeLa-SC population X-irradiated repeatedly for five times with 800 rad. The mean lethal dose (D 0 ) was 196 rad for X-8-5 cells, while it was 166 rad for control HeLa-SC cells. The fraction of cells containing an unusually long acrocentric chromosome (LA 2) exclusively increased with increasing number of irradiation of HeLa-SC population. A clonal strain with LA 2 marker was isolated from X-8-5 population and named RC-355. Since the RC-355 cells were more resistant (D 0 = 220 rad)than parental X-8-5 cells (D 0 = 196 rad), it was suggested that the cells with LA 2 were responsible for the radioresistance of X-8-5 population. The RC-355 cells were further subjected to the analysis of Q-banded karyotypes and it was observed that 18 types of specific markers (rm 1-17 and LA 2) were included in RC-355 cells in addition to 12 types of markers observed in most of HeLa-SC cells. Since the analysis of Q-banded karyotypes of RC-355 cells showed that RC-355 specific markers were not produced by radiation-induced rearrangements of HeLa-SC chromosomes, because twelve kinds of HeLa-SC markers were presented in RC-355 cells without any change, it was concluded that a small number of cells with LA 2 marker were originally presented in the control population and the relative fraction of them occupied increased after irradiation. (author)

Loss of PTEN Facilitates Rosiglitazone-Mediated Enhancement of Platinum(IV) Complex LA-12-Induced Apoptosis in Colon Cancer Cells

Czech Academy of Sciences Publication Activity Database

Lauková, Jarmila; Kozubík, Alois; Hofmanová, Jiřina; Nekvindová, J.; Sova, P.; Moyer, M.P.; Ehrmann, J.; Vaculová, Alena

2015-01-01

Roč. 10, č. 10 (2015) E-ISSN 1932-6203 R&D Projects: GA ČR(CZ) GA15-06650S Institutional support: RVO:68081707 Keywords : ACTIVATED-RECEPTOR-GAMMA * PPAR-GAMMA * ANTITUMOR EFFICACY Subject RIV: BO - Biophysics Impact factor: 3.057, year: 2015

Meningiomas del foramen magno: Reporte de 12 casos y revisión de la literatura

Science.gov (United States)

Campero, Álvaro; Ajler, Pablo; Roman, Guillermo; Rivadeneira, Conrado

2017-01-01

Resumen Objetivo: El propósito del presente trabajo es presentar los resultados de 12 pacientes con diagnóstico de meningiomas del foramen magno (MFM), de localización anterior o lateral, operados con técnicas microquirúrgicas. Método: Desde Junio de 2005 a Diciembre de 2016, 12 pacientes con diagnóstico de MFM fueron intervenidos quirúrgicamente. Se evaluó: edad, sexo, localización de la lesión (anterior o lateral), sintomatología, tipo de abordaje utilizado y resultados postoperatorios. Resultados: De los pacientes intervenidos, 8 fueron mujeres y 4 varones. La edad promedio fue de 47 años. La localización fue anterior en 8 casos y lateral en 4 casos. La sintomatología más frecuente fue dolor occipito-cervical (8 casos), seguido de tetraparesia (3 casos). En los pacientes con MFM de localización anterior se realizó un abordaje extremo-lateral transcondilar (ELTC), mientras que en los tumores laterales el abordaje fue extremo-lateral retrocondilar (ELRC). En 10 casos la resección fue completa. En dos pacientes fue necesario dejar una pequeña lámina de meningioma sobre la arteria vertebral y a nivel del foramen yugular. Como complicaciones postoperatorias, 3 pacientes presentaron una paresia del XII nervio craneano y 2 pacientes paresia del XI nervio craneano; además, 1 paciente presentó una fístula de LCR. Conclusión: La cirugía de los MFM de localización anterior y lateral puede ser realizada de forma segura y efectiva. Es necesario: a) buen conocimiento anatómico de la región; b) disecar los músculos de la nuca en 2 planos, exponiendo el triángulo suboccipital y la arteria vertebral (AV); 3) realizar un abordaje ELRC en los tumores laterales, y ELTC en los tumores anteriores; y 4) buena técnica microquirúrgica. PMID:29142778

Hexagonal perovskites with cationic vacancies. 18. Structure of the rhombohedral 12 L-stacking polytypes Ba/sub 2/La/sub 2/Bsup(II)(W/sub 2/sup(VI)vacantO/sub 12/)

Energy Technology Data Exchange (ETDEWEB)

Rother, H J; Fadini, A; Kemmler-Sack, S [Tuebingen Univ. (Germany, F.R.). Lehrstuhl fuer Anorganische Chemie 2

1980-04-01

According to the intensity calcualtions for Ba/sub 2/La/sub 2/Zn(W/sub 2/vacantO/sub 12/) the compounds of this type crystallize in the space group R3m-Dsub(3d)/sup 5/ with the sequence (3)(1)equivalent (hhcc)/sub 3/. The refined, intensity related R' value is 5,8%. The octahedral net consists of blocks of three face connected octahedra which are linked to each other by corner sharing BO/sub 6/ octahedra. The cationic vacancies are located in the centers of the groups of three octahedra. The two tungsten atoms in the outer positions are displaces by about 0.13 A from their ideal positions in direction of the central void. The (Ba, La) atoms neighbouring a vacancy (all in hexagonal close packed (Ba, La)O/sub 3/ sheets) are also dislocated in direction of the void, while the (Ba, La) atoms in the cubic packed sheets maintain nearly their ideal positions. The vibrational spectra of the compounds Ba/sub 2/La/sub 2/ Bsup(II)(W/sub 2/vacantO/sub 12/) are discussed. The force constants for the W/sub 2/vacantO/sub 12/ groups (factor group and Ppoint Dsub(3d)) were calculated and compared with the correspoinding values of Re/sub 2/vacantO/sub 12/ and ReWvacantO/sub 12/ units.

Luminescence and excited state dynamics in Bi{sup 3+}-doped LiLaP{sub 4}O{sub 12} phosphates

Energy Technology Data Exchange (ETDEWEB)

Babin, V. [Institute of Physics AS CR, Cukrovarnicka 10, 16200 Prague (Czech Republic); Chernenko, K., E-mail: nuclearphys@yandex.ru [Institute of Physics, University of Tartu, Ravila 14c, 50411 Tartu (Estonia); Peter the Great Saint-Petersburg Polytechnic University, Polytekhnicheskaya 29, 195251 St.Petersburg (Russian Federation); Demchenko, P. [Ivan Franko National University of Lviv, Kyryla i Mefodiya 8a, 79005 Lviv (Ukraine); Mihokova, E.; Nikl, M. [Institute of Physics AS CR, Cukrovarnicka 10, 16200 Prague (Czech Republic); Pashuk, I. [Ivan Franko National University of Lviv, Kyryla i Mefodiya 8a, 79005 Lviv (Ukraine); Shalapska, T. [Institute of Physics, University of Tartu, Ravila 14c, 50411 Tartu (Estonia); Voloshinovskii, A. [Ivan Franko National University of Lviv, Kyryla i Mefodiya 8a, 79005 Lviv (Ukraine); Zazubovich, S. [Institute of Physics, University of Tartu, Ravila 14c, 50411 Tartu (Estonia)

2016-08-15

Photo- and X-ray-excited luminescence characteristics of Bi-doped LiLaP{sub 4}O{sub 12} phosphates with different bismuth contents (from 1 to 25 at% in the melt) are investigated in the 4.2–300 K temperature range and compared with the characteristics of the undoped LiLaP{sub 4}O{sub 12} phosphate. The broad 2.95 eV emission band of LiLaP{sub 4}O{sub 12}:Bi excited around 5.4 eV is found to arise from the bismuth dopant. Relatively large FWHM and Stokes shift of the emission band and especially the data on the low-temperature decay kinetics of the 2.95 eV emission and its temperature dependence, indicating a very small spin-orbit splitting energy of the corresponding excited state, allow the conclusion that this emission arises from the radiative decay of the triplet state of an exciton localized around a Bi{sup 3+} ion. No spectral bands are observed, arising from the electron transitions between the energy levels of Bi{sup 3+} ions. Phenomenological model is proposed for the description of the excited state dynamics of the Bi{sup 3+}-related localized exciton in LiLaP{sub 4}O{sub 12}:Bi and the parameters of the triplet localized exciton state are determined. Keywords: Photoluminescence; Time-resolved spectroscopy; Excited states; Bi{sup 3+} centers; LiLaP{sub 4}O{sub 12}:Bi powders.

Ingesta de alimentos, energía y nutrientes en la población de 5 a 12 años de la Comunidad de Madrid: resultados de la encuesta de nutrición infantil 2001-2002.

OpenAIRE

Lucía Díez-Gañán; Iñaki Galán Labaca; Carmen María León Domínguez; Ana Gandarillas Grande; Belén Zorrilla Torras; Francisca Alcaraz Cebrián

2007-01-01

Fundamento: Para conocer la situación alimentaria y nutricional en la población infantil, sobre la que no existía información actualizada, el Instituto de Salud Pública desarrolló la Encuesta de Nutrición Infantil de la Comunidad de Madrid 2001/2002 (ENICM). En este trabajo se analiza la ENICM para describir y evaluar la ingesta de alimentos, energía y nutrientes en esta población. Métodos: Estudio transversal sobre una muestra representativa de la población de 5-12 años ...

Magnetocaloric effect, thermal conductivity, and magnetostriction of epoxy-bonded La(Fe0.88Si0.12)13 hydrides

Science.gov (United States)

Matsumoto, K.; Murayama, D.; Takeshita, M.; Ura, Y.; Abe, S.; Numazawa, T.; Takata, H.; Matsumoto, Y.; Kuriiwa, T.

2017-09-01

Magnetic materials with large magnetocaloric effect are significantly important for magnetic refrigeration. La(Fe0.88Si0.12)13 compounds are one of the promising magnetocaloric materials that have a first order magnetic phase transition. Transition temperature of hydrogenated La(Fe0.88Si0.12)13 increased up to room temperature region while keeping metamagnetic transition properties. From view point of practical usage, bonded composite are very attractive and their properties are important. We made epoxy bonded La(Fe0.88Si0.12)13 hydrides. Magnetocaloric effect was studied by measuring specific heat, magnetization, and temperature change in adiabatic demagnetization. The composite had about 20% smaller entropy change from the hydrogenated La(Fe0.88Si0.12)13 powder in 2 T. Thermal conductivity of the composite was several times smaller than La(Fe,Si)13. The small thermal conductivity was explained due to the small thermal conductivity of epoxy. Thermal conductivity was observed to be insensitive to magnetic field in 2 T. Thermal expansion and magnetostriction of the composite material were measured. The composite expanded about 0.25% when it entered into ferromagnetic phase. Magnetostriction of the composite in ferromagnetic phase was about 0.2% in 5 T and much larger than that in paramagnetic phase. The composite didn’t break after about 100 times magnetic field changes in adiabatic demagnetization experiment even though it has magnetostriction.

Modification of the water-level control system at the Unit 12 of Los Azufres, Mich., geothermal field; Modificacion del sistema de control de nivel de agua en la Unidad 12 del campo geotermico de Los Azufres, Mich.

Energy Technology Data Exchange (ETDEWEB)

Tello Hinojosa, Raul; Aburto Huerta, S. Ramon; Mendoza Covarrubias, Hector M [Comision Federal de Electricidad, Gerencia de Proyectos Geotermoelectricos, Morelia, Michoacan (Mexico)]. E-mail: raul.tello@cfe.gob.mx

2007-01-15

Unit 12 of the Los Azufres, Mich., geothermal field is a binary cycle unit of 1.45 MW, installed at the pad of production well Az-22. There are two separators on this pad. One separates the mix extracted from well Az-22 and the other from adjacent wells. The separated brine from both separators is gathered in a horizontal tank and sent to Unit 12. The steam is sent to Unit 7, which generates 50 MW. Once some interference occurred affecting the power generation of Unit 7 when Unit 12 was off line. This was caused by the original flow arrangement and water-level control system. To avoid interference, a water-level control system was designed and installed in the separators. The system operates independently of Unit 12, with tanks in each separator connected by a pipe. Regulation of the water level is accomplished by three motor valves and a level sensor. To ensure permanent feeding of electrical power to the valves, an automatic system was installed from transmission lines of 23 and 115 kV. In case both lines fail, there is an uninterrupted power supply (UPS) unit. At the beginning of 2005, Unit 12 was again online with a modified water-level control system that has operated satisfactorily since then. Its short periods offline have not affected Unit 7. [Spanish] La Unidad 12 del campo geotermico de Los Azufres, Mich., es una unidad de ciclo binario de 1.45 MW, instalada en la plataforma del pozo productor Az-22. En esta plataforma hay dos separadores, uno de los cuales separa la mezcla extraida del pozo Az-22 y el otro la de varios pozos aledanos. El agua separada de ambos se concentra en un tanque horizontal y de este pasa a la Unidad 12, mientras que el vapor se envia a la Unidad 7, de 50 MW. Por el tipo de arreglo original de flujo y control de nivel de agua en los equipos, ocurrian interferencias que provocaban que cuando la Unidad 12 se disparaba se afectara la generacion en la Unidad 7. Para evitar esta interferencia se diseno e instalo un sistema de control de

Teoría de la Arquitectura. 12_Paisajismo

OpenAIRE

Martínez Medina, Andrés

2012-01-01

Documentación gráfica y escrita (ppt/pdf) que desarrolla las relaciones entre la corriente filosófica del sensualismo británico, la ciencia nueva y moderna con la naturaleza y de esta con la arquitectura (y finalmente con el urbanismo), a través del Paisajismo (y el jardín inglés). Repaso a las concepciones barrocas e ilustradas de la relación del hombre y la arquitectura con la naturaleza.

Superconductivity and transport properties in LaRu4Sb12 single crystals probed by radiation-induced disordering

International Nuclear Information System (INIS)

Goshchitskii, B.; Naumov, S.; Kostromitina, N.; Karkin, A.

2007-01-01

Resistivity ρ(T) and Hall coefficient R H (T) in magnetic fields H up to 14 T were studied in superconducting (T c = 3.3 K) LaRu 4 Sb 12 single crystals disordered by fast neutron irradiation. Atomic disordering leads to increase in residual resistivity ρ 0 , decrease of Hall number and suppression of superconductivity. The upper critical field slope -dH c2 /dT increases approximately linear with ρ 0 . The irradiation effects are almost recovered after annealing at 500 deg. C. The observed radiation-induced effects in LaRu 4 Sb 12 are compared with those in PrOs 4 Sb 12 in terms of unconventional mechanisms of superconductivity

Expresión y purificación del antígeno preS1/2 y su utilidad en el estudio de la patogenia de la infección por el virus de la hepatitis B

Directory of Open Access Journals (Sweden)

Masyelly D. Rojas P

2013-05-01

Full Text Available El preS1/2 es parte de las proteínas de envoltura del virus de la hepatitis B (VHB, con funciones importantes en la inmunopatogenia de la enfermedad. Para su estudio es necesario contar con la proteína pura y así dilucidar su participación en el daño generado en el tejido hepático. Para ello se procedió a la expresión del preS1/2 previamente clonado en el vector peT3d, en la cepa de E coli HMS174 (DE3, seguido por su purificación mediante columnas de afinidad hacia residuos de histidina (6xhistidina y finalmente sometidas a liberación de contaminantes mediante el uso de columnas de afinidad hacia endotoxina y filtración por centrifugación, de esta manera utilizarla para evaluar su efecto sobre hepatocitos humanos. El procedimiento utilizado permitió obtener 1,5 mg de proteína pura funcionalmente estable por cada litro de medio de cultivo. En este trabajo se describe un método sencillo de expresión y purificación del preS1/2 recombinante y se evidencia la obtención de un producto intacto, con potencial uso en estudios funcionales y futuros ensayos terapéuticos Expression and purification of preS1/2 antigen and its usefulness in the hepatitis B virus pathogenesis study Abstract The preS1/2 belongs to the envelope proteins of the hepatitis B virus (HBV, and has an important role in the pathogenesis of the disease. A pure protein is important for their study, and thus elucidates their involvement in the liver tissue damage observed during the diseases. For this purpose preS1/2 previously cloned into the pET3d was expressed in E. coli strain HMS174 (DE3, subsequent was purified by affinity columns histidine residues (6xhistidine and finally treated to release contaminants by using affinity columns endotoxin and filtration by centrifugation, thereby used it to assess their effect on human hepatocytes. The procedure yielded 1,5 mg pure protein per liter of culture medium, functionally stable. In this paper we describe a simple method

La penicilina y sus derivados como agentes desencadenantes de la respuesta inmune Penicillin and its derivatives as immune response unleashing agents

Directory of Open Access Journals (Sweden)

Yulién Alpízar Olivares

2000-08-01

Full Text Available Con el uso de la penicilina y sus derivados aparecen comúnmente reacciones de hipersensibilidad. Con el fin de caracterizarlas, se estudia la estructura química de estos antibióticos y su influencia en dichas reacciones. Existen factores que pueden predisponer al desarrollo de estos efectos adversos, entre los que se encuentran la gran heterogeneidad en la restricción por el sistema principal de histocompatibilidad (SPH, el fenotipo de los clones celulares reactivos a estas drogas y el patrón de citocinas que se liberan. Todo lo anterior da origen al cuadro clínico tan diverso que exhiben las reacciones causadas por estos fármacos. La profundización en el conocimiento de los mecanismos que condicionan estas respuestas constituye un reto para los investigadores en el campo de la inmunologíaThe use of penicillin and its derivatives very often brings about hypersensitivity reactions. To characterize them, we studied the chemical structure of these antibiotics and their influence on such reactions. There are factors that may predispose people to the development of these adverse reactions, among them are the great heterogeneity in restriction by the main histocompatibility system, the phenotype of reactive cell clones to these drugs and the pattern of cytokines that are released. All the above-mentioned gives rise to the so diverse clinical picture of the reactions caused by these drugs. Widening of knowledge on mechanisms leading to these reactions becomes a challenge for researchers in the field of immunology

Les tumeurs desmoides de la paroi thoracique : à propos de 12 cas Dermoid tumors of the thoracic wall: about 12 cases

Directory of Open Access Journals (Sweden)

Abdellatif Benosman

2009-11-01

Full Text Available Les tumeurs desmoides sont des tumeurs rares des tissus mous qui peuvent être très agressives localement. A travers l’expérience de notre service, nous analyserons les résultats du traitement chirurgical de ces tumeurs. De 1980 à 2008, 12 patients ont été opérés pour tumeur desmoide de la paroi thoracique. Le diagnostic a été suspecté sur la base des signes cliniques et radiologiques. Aucun patient n’avait un syndrome de Gardner. L’abord chirurgical a été souvent électif à l’aplomb de la tumeur. La résection a été complète dans 11 cas. La confirmation diagnostique a été apportée par l’étude histologique de la pièce opératoire. La durée du suivi post opératoire variait entre 24 et 180 mois. Une patiente était décédée par insuffisance cardiaque et rénale. 7 cas avaient récidivé, et qui ont été traités par simple résection complète dans 5 cas, dont un avait nécessité une greffe myocutanée ; par ailleurs, deux cas ont été traités par résection incomplète associée à une radiothérapie adjuvante. La chirurgie des tumeurs desmoides de la paroi thoracique doit être aussi large que possible pour diminuer le risque de récidive.

Systematic study of photoluminescence upon band gap excitation in perovskite-type titanates R 1/2Na1/2TiO3:Pr (R=La, Gd, Lu, and Y)

International Nuclear Information System (INIS)

Inaguma, Yoshiyuki; Tsuchiya, Takeshi; Katsumata, Tetsuhiro

2007-01-01

Pr 3+ -doped perovskites R 1/2 Na 1/2 TiO 3 :Pr (R=La, Gd, Lu, and Y) were synthesized, and their structures, optical absorption and luminescent properties were investigated, and the relationship between structures and optical properties are discussed. Optical band gap of R 1/2 Na 1/2 TiO 3 increases in the order R=La, Gd, Y, and Lu, which is primarily due to a decrease in band width accompanied by a decrease in Ti-O-Ti bond angle. Intense red emission assigned to f-f transition of Pr 3+ from the excited 1 D 2 level to the ground 3 H 4 state upon the band gap photo-excitation (UV) was observed for all compounds. The wavelength of emission peaks was red-shifted in the order R=La, Gd, Y, and Lu, which originates from the increase in crystal field splitting of Pr 3+ . This is attributed to the decrease in inter-atomic distances of Pr-O together with the inter-atomic distances (R, Na)-O, i.e., increase in covalency between Pr and O. The results indicate that the luminescent properties in R 1/2 Na 1/2 TiO 3 :Pr are governed by the relative energy level between the ground and excited state of 4f 2 for Pr 3+ , and the conduction and valence band, which is primarily dependent on the structure, e.g., the tilt of TiO 6 octahedra and the Pr-Ti inter-atomic distance and the site symmetry of Pr ion. - Graphical abstract: The red intense emission assigned to f-f transition of Pr 3+ from the excited 1 D 2 level to the ground 3 H 4 state upon the band gap photo-excitation (UV) was observed upon the band gap photo-excitation in perovskites R 1/2 Na 1/2 TiO 3 :Pr(R=La, Gd, Lu, and Y). It was found that the systematic changes in their luminescent properties are strongly dependent on the structure

Tšaikovski, P. La Fille des neiges (musique de scene op. 12) / Serge Martin

Index Scriptorium Estoniae

Martin, Serge

1995-01-01

Uuest heliplaadist "Tšaikovski, P. La Fille des neiges (musique de scene op. 12). University Musical Society Choral Union. Detroit Symphony Orchestra, Neeme Järvi. Chandos CHAN 9324, distribution Media 7 (CD: 157 F). 1994. TT: 1h 19'04"

Seroprevalencia de HTLV-1/2 en donantes de sangre de la Provincia de Misiones Seroprevalence of HTLV-1/2 in blood donors from Misiones Province

Directory of Open Access Journals (Sweden)

Richard Malan

2010-02-01

Full Text Available El Virus Linfotrópico T Humano tipo 1 (HTLV-1, primer oncorretrovirus humano descubierto, es el causante etiológico de la leucemia de células T del adulto (ATL y de la mielopatía asociada al HTLV-1 o paraparesia espástica tropical (HAM/TSP. Es endémico en distintas partes del mundo, inclusive en el noroeste argentino, donde ambas enfermedades fueron detectadas. El HTLV-2, no tiene un rol etiológico definido, si bien ha sido asociado con síndromes neurológicos similares a la HAM/TSP. Ambos virus son endémicos en comunidades originarias del continente americano, tribus de Africa y poblaciones en riesgo. Ambos retrovirus se transmiten por vía sexual, parenteral y de madre a hijo. El objetivo de este trabajo fue determinar la seroprevalencia de HTLV-1/2 en una población de donantes de sangre de la provincia de Misiones. Se analizaron 6912 donaciones de sangre recibidas en el Banco de Sangre Central de la Provincia de Misiones durante 2008. La detección de anticuerpos se realizó por ELISA y aglutinación de partículas, y las muestras reactivas fueron confirmadas por Western Blot. Del total de muestras, 5 resultaron seropositivas con una prevalencia final de 0.00072. De ellas, una era HTLV, tres HTLV-1 y una HTLV-2 positiva. Los donantes positivos provenían de Posadas, Eldorado y Oberá, sin antecedentes de riesgo. Este estudio demuestra la presencia de HTLV-1/2 en donantes de sangre de Misiones, con cifras similares a las notificadas en donantes de sangre de zonas no endémicas.Human T-cell Lymphotropic viruses type 1 (HTLV-1, the first human oncoretrovirus to be discovered, is the etiologic agent of Adult T-cell Leukemia (ATL and HTLV-1 Associated Mielopathy or Tropical Spastic Paraparesis (HAM/TSP. It is endemic worldwide, including the North of Argentina where both associated diseases have also been detected. No etiologic role has been described for HTLV-2, although it has been associated with HAM/TSP-like neurologic syndromes

Conventional proximity effect in bilayers of superconducting underdoped $La_{1.88}Sr_{0.12}CuO_4$ islands coated with non superconducting overdoped $La_{1.65}Sr_{0.35}CuO_4$

OpenAIRE

Koren, G.; Millo, O.

2009-01-01

Following a recent study by our group in which a large $T_c$ enhancement was reported in bilayers of the non-superconducting $La_{1.65}Sr_{0.35}CuO_4$ and superconducting $La_{1.88}Sr_{0.12}CuO_4$ films [Phys. Rev. Lett. \\textbf{101}, 057005 (2008)], we checked if a similar effect occurs when superconducting $La_{1.88}Sr_{0.12}CuO_4$ islands are coated with a continuous layer of the non superconducting $La_{1.65}Sr_{0.35}CuO_4$. We found that no such phenomenon is observed. The bare supercond...

Tannic Acid an Efficient Catalyst for the Synthesis of 12-aryl-8,9,10,12-tetrahydrobenzo[a]xanthen-11-one Derivatives

Directory of Open Access Journals (Sweden)

Deepak S. Kawade

2015-06-01

Full Text Available Tannic acid explore a highly efficient catalytic activity for the synthesis of 12-aryl-8,9,10,12-tetrahydrobenzo[a]xanthen-11-one derivatives in excellent yields via cyclocondensation of aromatic aldehyde, β-naphthol and dimedone. Catalyst having advantages such as it is cheap and biodegradable and the protocol avoids the use of expensive catalyst and toxic solvent. We believe that this methodology is an efficient, simple, highly yielding, time saving and environmentally friendly. DOI: http://dx.doi.org/10.17807/orbital.v7i2.683

Hexagonal perovskites with cationic vacancies. 21. Structure of Ba/sub 4/Nb/sub 2/WvacantO/sub 12/ and Ba/sub 3/LaNb/sub 3/vacantO/sub 12/

Energy Technology Data Exchange (ETDEWEB)

Rother, H J; Kemmler-Sack, S; Treiber, U; Cyris, W R [Tuebingen Univ. (Germany, F.R.). Lehrstuhl fuer Anorganische Chemie 2

1980-07-01

Compounds of type Ba/sub 4/M/sub 2/sup(V)WvacantO/sub 12/ and Ba/sub 3/LaM/sub 3/sup(V)vacantO/sub 12/ with Msup(V) = Nb, Ta belong to the group of rhombohedral 12 L stacking polytypes (space group R-3m, sequence (hhcc)/sub 3/). The structure determinations on powder patterns for the Nb compounds gave a refined, intensity related R' value of 6.3% (Ba/sub 4/Nb/sub 2/WvacantO/sub 12/) and 6.6% (Ba/sub 3/LaNb/sub 3/vacantO/sub 12/). The octahedral net consists of blocks of three face connected octahedra with a central void (M/sub 2/vacantO/sub 12/ unit), which are linked to each other through single corner sharing octahedra. In both compounds the M atoms in the M/sub 2/vacantO/sub 12/ groups are displaced in the direction of the central void. The A atoms move in the same direction but the dislocation for A in the hexagonal packed sheets (neighbouring the vacancies) is stronger than in the cubic packed AO/sub 3/ sheets. The results of the vibrational spectroscopic investigations are reported for Ba/sub 4/Nb/sub 2/WvacantO/sub 12/, Ba/sub 4/Ta/sub 2/WvacantO/sub 12/, Ba/sub 3/LaNb/sub 3/vacantO/sub 12/ and Ba/sub 4/CeW/sub 2/vacantO/sub 12/; they are discussed in connection with the factor group analysis.

Anomalous enhancement of the lower critical field deep in the superconducting state of LaRu4As12

Science.gov (United States)

Juraszek, J.; Bochenek, Ł.; Wawryk, R.; Henkie, Z.; Konczykowski, M.; Cichorek, T.

2018-05-01

LaRu4As12 with the critical temperature Tc = 10.4 K displays several features which point at a non-singlet superconducting order parameter, although the bcc crystal structure of the filled skutterudites does not favour the emergence of multiple energy gaps. LaRu4As12 displays an unexpected enhancement of the lower critical field deep in superconducting state which can be attributed to the existence of two superconducting gaps. At T = 0.4 K, the local magnetization measurements were performed utilizing miniaturized Hall sensors.

Electronic and Transport Properties of LaNi4Sb12 Skutterudite: Modified Becke-Johnson Approach

Science.gov (United States)

Bhat, Tahir Mohiuddin; Singh, Srishti; Gupta, Dinesh C.

2018-05-01

We carried out an ab initio study of structural, electronic, thermodynamic, and thermoelectric properties of the lanthanum-filled skutterudite, LaNi4Sb12. Generalized gradient approximation and modified Becke-Johnson potentials were employed for the exchange-correlation potential. The electronic structure calculations display the metallic behavior of the compound. The alloy offers low lattice thermal conductivity along with a high Seebeck coefficient with a value of - 158 (μVK-1) at room temperature. The effect of high pressure and temperature on thermal properties like thermal expansion coefficient, heat capacity, and Grüneisen parameter are also investigated by means of a quasi-harmonic Debye model. The large Seebeck coefficient and high power factor exhibited by LaNi4Sb12 make it an attractive candidate for thermoelectric materials.

Relación entre la capacidad cardiorrespiratoria y el rendimiento en los tests de condición física relacionada con la salud incluidos en la batería ALPHA en niños de 10-12 años

Directory of Open Access Journals (Sweden)

Daniel Mayorga-Vega

2013-01-01

Full Text Available La condición física es considerada un importante marcador relacionado con la salud en la infancia. Entre sus diferentes componentes, la resistencia cardiorrespiratoria ha sido la que constituye el principal exponente de salud. Sin embargo, su relación con otros componentes de la condición física aún no ha sido ampliamente estudiada entre los niños. El objetivo del presente estudio fue analizar la relación de presentar una alta (o baja capacidad cardiorrespiratoria y el nivel de condición física relacionada con la salud en niños de 10-12 años. Una muestra de 72 escolares (niños, n = 37; niñas, n = 35 voluntarios de 10-12 años de edad participaron en el presente estudio. Los estudiantes fueron evaluados mediante la batería ALPHA basada en la evidencia durante dos clases de Educación Física. En la primera sesión se realizaron las medidas de composición corporal (peso, talla y pliegues cutáneos y en la segunda las pruebas de dinamometría manual, salto de longitud y Course Navette. Los niños que presentaban una alta condición física cardiovascular (> percentil 50 en las marcas del test Course Navette mostraron menores valores de IMC, pliegues cutáneos, porcentaje de grasa corporal, así como mayores valores de salto de longitud, Course Navette y consumo máximo de oxígeno estimado que los del grupo de baja condición física cardiovascular (< percentil 50 en las marcas del test Course Navette. Las pruebas incluidas en la batería de tests ALPHA basada en la evidencia parecen presentar una clara relación con la salud cardiovascular de los niños de 10-12 años.

New lanthanide(III) complexes of chiral nonadendate macrocyclic amine derived from (1R,2R)-1,2-diaminocyclohexane and 2,6-diformyl-4-methylphenol

Energy Technology Data Exchange (ETDEWEB)

Paluch, Marta [Department of Chemistry, University of Wroclaw, 14 F. Joliot-Curie, 50-383 Wroclaw (Poland); Lisowski, Jerzy [Department of Chemistry, University of Wroclaw, 14 F. Joliot-Curie, 50-383 Wroclaw (Poland)], E-mail: jurekl@wchuwr.chem.uni.wroc.pl

2008-02-28

The series of complexes [LnH{sub 4}L(NO{sub 3}){sub 2}](NO{sub 3}){sub 2}.nH{sub 2}O (Ln = La, Ce, Pr, Nd, Gd, Tb, Ho, Er, Tm) of the positively charged protonated form of a chiral macrocyclic amine H{sub 4}L{sup +}, derived from the 3 + 3 condensation product of (1R,2R)-1,2-diaminocyclohexane and 2,6-diformyl-4-methylphenol, have been synthesized. The series of complexes Na{sub x}[LnL](X){sub y}(OH){sub x-y}.n(solv) (X = NO{sup 3-} or Cl{sup -}, and Ln = La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu) of the deprotonated anionic form of the ligand, L{sup 3-}, have also been synthesised. The complexes have been characterised by elemental analyses, {sup 1}H NMR and ESI MS spectra. The X-ray crystal structures of the [LaH{sub 4}L(NO{sub 3}){sub 2}](NO{sub 3}){sub 2}.5CH{sub 3}OH and [GdH{sub 4}L(NO{sub 3}){sub 2}](NO{sub 3}){sub 2}.5CH{sub 3}OH complexes have been determined. The two complexes are isostructural, and the protonated macrocycle acts as pentadentate ligand. The Ln(III) ion is bound to three phenolate oxygen atoms and two amine nitrogen atoms of the macrocyclic ligand and its coordination sphere is completed by the two axial bidendate nitrate anions.

Efecto sobre la viabilidad celular de una nueva serie de espirosteroides sintéticos en células PC12

Directory of Open Access Journals (Sweden)

Laura García-Pupo

2013-03-01

Full Text Available Introducción: la diosgenina y sus derivados se han descrito como potentes inhibidores de la proliferación en varias líneas tumorales. Sin embargo otras moléculas relacionadas estructuralmente con dichos derivados, se han reportado como candidatos terapéuticos y otras de ellas se incluyen en alimentos de consumo humano. Objetivo: el presente trabajo evalúa el efecto sobre la viabilidad celular de una nueva serie de espiroesteroides sintéticos derivados de la diosgenina, en células tipo neurales PC12. Métodos: la viabilidad de los cultivos de PC12 se determinó mediante el ensayo de MTT y se calcularon descriptores moleculares teóricos como la lipofilicidad (logP virtual y la superficie de área polar (SAP, con el objetivo de establecer relaciones estructura-actividad. Resultados: nuestros resultados demuestran que solo el acido taurodesoxicólico disminuye de manera significativa la viabilidad celular. Más aun, dicha molécula presenta valores menores y mayores de logP virtual y SAP, respectivamente, respecto al resto de los esteroides de la serie. Conclusiones: los resultados anteriores avalan el estudio del acido taurodesoxicólico como potencial inhibidor de la proliferación celular y al resto de las moléculas de la serie como candidatos neuroprotectores a evaluar en esta misma línea celular y dosis de tratamiento.

EFFET DES VITAMINES B12, B9 ET B6 ET LEURS INTERACTIONS SUR LA FRAGILITE OSMOTIQUE DES ERYTHROCYTES HUMAINS

Directory of Open Access Journals (Sweden)

B HOUCHER

2001-06-01

Full Text Available L’effet des vitamines B12, B9 et B6 sur la fragilité osmotique des érythrocytes humains a été exploré in vitro. De fortes concentrations de vitamines B12 et B6 ont protégé les érythrocytes de l’hémolyse hypotonique, avec une protection maxima atteinte respectivement à 10 et 500 µg/ml. A concentrations plus faibles, cependant, ces vitamines ont favorisé grandement l’hémolyse hypotonique. Par contre, la vitamine B9 a montré uniquement un effet hémolytique de 4 à 200 µg/ml. Cet effet peut être expliqué par la nature acide de la molécule. L’effet nul sur la fragilité osmotique de deux vitamines antagonistes, peut probablement être expliqué par l’antagonisme partiel ou par la présence de ces deux vitamines simultanément: ces dernières se lient en quantités appréciables à la cellule intacte de même qu’à l’hémolysat et il y’ a compétition mutuelle entre ces vitamines et leur transport.

The celecoxib derivatives AR-12 and AR-14 induce autophagy and clear prion-infected cells from prions.

Science.gov (United States)

Abdulrahman, Basant A; Abdelaziz, Dalia; Thapa, Simrika; Lu, Li; Jain, Shubha; Gilch, Sabine; Proniuk, Stefan; Zukiwski, Alexander; Schatzl, Hermann M

2017-12-14

Prion diseases are fatal infectious neurodegenerative disorders that affect both humans and animals. The autocatalytic conversion of the cellular prion protein (PrP C ) into the pathologic isoform PrP Sc is a key feature in prion pathogenesis. AR-12 is an IND-approved derivative of celecoxib that demonstrated preclinical activity against several microbial diseases. Recently, AR-12 has been shown to facilitate clearance of misfolded proteins. The latter proposes AR-12 to be a potential therapeutic agent for neurodegenerative disorders. In this study, we investigated the role of AR-12 and its derivatives in controlling prion infection. We tested AR-12 in prion infected neuronal and non-neuronal cell lines. Immunoblotting and confocal microscopy results showed that AR-12 and its analogue AR-14 reduced PrP Sc levels after only 72 hours of treatment. Furthermore, infected cells were cured of PrP Sc after exposure of AR-12 or AR-14 for only two weeks. We partially attribute the influence of the AR compounds on prion propagation to autophagy stimulation, in line with our previous findings that drug-induced stimulation of autophagy has anti-prion effects in vitro and in vivo. Taken together, this study demonstrates that AR-12 and the AR-14 analogue are potential new therapeutic agents for prion diseases and possibly protein misfolding disorders involving prion-like mechanisms.

Low-temperature synthesis of Li{sub 7}La{sub 3}Zr{sub 2}O{sub 12} with cubic garnet-type structure

Energy Technology Data Exchange (ETDEWEB)

Xie, Hui [Texas Materials Institute, ETC 9.184, University of Texas at Austin, Austin, TX 78712 (United States); Li, Yutao [Texas Materials Institute, ETC 9.184, University of Texas at Austin, Austin, TX 78712 (United States); State Key Laboratory of New Ceramics and Fine Processing, Department of Materials Science and Engineering, Tsinghua University, Beijing 100084 (China); Goodenough, John B., E-mail: jgoodenough@mail.utexas.edu [Texas Materials Institute, ETC 9.184, University of Texas at Austin, Austin, TX 78712 (United States)

2012-05-15

Highlights: Black-Right-Pointing-Pointer One-step synthesis and its optimization of cubic garnet Li{sub 7}La{sub 3}Zr{sub 2}O{sub 12} at 750 Degree-Sign C. Black-Right-Pointing-Pointer Instability above 800 Degree-Sign C of the Al-free cubic Li{sub 7}La{sub 3}Zr{sub 2}O{sub 12}. Black-Right-Pointing-Pointer Li{sup +}-ion conductivity without adventitious Al{sup 3+}. -- Abstract: In this paper, we report the direct synthesis of Li{sub 7}La{sub 3}Zr{sub 2}O{sub 12} with the cubic garnet-type structure at low temperature with a lattice constant of 13.0035 Angstrom-Sign . The synthesis condition is optimized to be at 750 Degree-Sign C for 8 h with 30 wt% excess lithium salt. No intermediate grinding was involved in this straightforward route. Without the adventitious of Al{sup 3+}, the cubic Li{sub 7}La{sub 3}Zr{sub 2}O{sub 12} is unstable above 800 Degree-Sign C and has an ionic conductivity of the order of 10{sup -6} S cm{sup -1}.

Metodología dirigida al desarrollo de la coordinación motriz en el Taekwondo categoría infantil 8 - 12 años de la provincia del Azuay

OpenAIRE

Chango Sigüenza, Joffre

2011-01-01

Esta tesis se ha desarrollado sobre la preparación de los deportistas de taekwondo entre los 8 a 12 años de edad que es la conocida como “La mejor edad de la infancia para el aprendizaje” en donde se desarrolla la técnica la formación multilateral, de motricidad y coordinación a formar y aumentar hábitos y habilidades. Se ha venido practicando este deporte a nivel competitivo como de formación tanto en damas como varones, en nuestro país se realiza en dos direcciones en lo marcial y en lo com...

Association between Genes BoLA-DRB3.2*8 and BoLA-DRB3.2*12 with Resistance and BoLA-DRB3.2*16 with Susceptibility to Infection by Bovine Leukemia Virus

Directory of Open Access Journals (Sweden)

C Úsuga-Monroy*, JJ Echeverri Zuluaga and A López-Herrera

2016-11-01

Full Text Available The Bovine Leukemia Virus (BLV is a retrovirus that affects the immune system of cattle as their target cells are B lymphocytes. Some polymorphisms at the BoLA-DRB 3.2 gene have been associated with resistance/susceptibility to diseases. The objective of this research was to determine the polymorphisms at the BoLA-DRB 3.2 gene and associate them with resistance (R, neutrality (N or susceptibility (S to BLV in a Holstein cow population.500 blood samples were taken. Nested PCR was performed for detecting BLV virus and PCR-RFLP was performed to identify alleles of gene BoLA-DRB 3.2. Susceptibility was determined using odds ratio (OR and P value. According to their genotype, cows were classified in homozygous (R/R, N/N, or S/S and heterozygous (R/N, R/S, N/S. BLV molecular prevalence was 44%. The most frequent allele was BoLA-DRB3.2*22 (16.8%, alleles associated with resistance to BLV were BoLA-DRB3.2*8 (OR=1.489; P<0.10 and BoLA-DRB3.2*12 (OR=3.897; P<0.10 and allele BoLA-DRB3.2*16 (OR=0.710; P<0.10 was associated with susceptibility. Allele BoLA-DRB3.2*8 had the highest allelic frequency for negative cows (0.19. 63.7% of cows with genotype RN and 70% of cows with genotype RR were resistant to infection by BLV. Alleles R and S have a dominant effect on allele N (P<0.05. The use of reliable diagnostic techniques in conjunction with identification of resistant or susceptible animals can monitor the progress of the disease in dairy herds. Alleles BoLA-DRB3.2*8 and *12 were positively related to the disease and therefore cows have low risk of infection, unlike allele BoLA-DRB3.2*16 which was negatively related and animals have high risk for the disease.

La identidad caribe en los 12 cuentos peregrinos.

OpenAIRE

Herrera Molina, Luis Carlos

2014-01-01

En un análisis tentativo sobre los Cuentos Peregrinos aparece una obsesión que trasciende la totalidad de estos cuentos: la identidad latinoamericana. Aspecto que queremos resaltar, para lo cual partimos de la posibilidad de darles una interpretación global.

Syntheses of cytotoxic novel arctigenin derivatives bearing halogen and alkyl groups on aromatic rings.

Science.gov (United States)

Yamauchi, Satoshi; Wukirsari, Tuti; Ochi, Yoshiaki; Nishiwaki, Hisashi; Nishi, Kosuke; Sugahara, Takuya; Akiyama, Koichi; Kishida, Taro

2017-09-01

The new lignano-9,9'-lactones (α,β-dibenzyl-γ-butyrolactone lignans), which showed the higher cytotoxicity than arctigenin, were synthesized. The well-known cytotoxic arctigenin showed activity against HL-60 cells (EC 50 =12μM), however, it was inactive against HeLa cells (EC 50 >100μM). The synthesized (3,4-dichloro, 2'-butoxy)-derivative 55 and (3,4-dichloro, 4'-butyl)-derivative 66 bearing the lignano-9,9'-lactone structures showed the EC 50 values of 10μM and 9.4μM against HL-60 cells, respectively. Against HeLa cells, the EC 50 value of the derivative 66 was 27μM. By comparing the activities with the corresponding 9,9'-epoxy structure (tetrahydrofuran compounds), the importance of the lactone structure of 55 and 66 for the higher activities was shown. The substituents on the aromatic ring of the lignano-9,9'-lactones affected the cytotoxicity level, observing more than 10-fold difference. Copyright © 2017. Published by Elsevier Ltd.

Clarín y Página/12 en el debate sobre la Ley de Servicios de Comunicación Audiovisual

Directory of Open Access Journals (Sweden)

Brenda Inés Di Paolo

2017-07-01

Full Text Available [es] El trabajo de investigación pretende dar cuenta de las modalidades enunciativas adoptadas por dos de los principales diarios de alcance nacional –Clarín y Página/12– en uno de los momentos de mayor tensión en la relación entre los medios concentrados de comunicación y el gobierno de Cristina Fernández de Kirchner, el debate sobre la Ley de Servicios de Comunicación Audiovisual (LSCA. La búsqueda se orienta a establecer criterios que delimiten la especificidad conceptual del campo de lo político y su relación con el campo de la comunicación. Pretende indagar en la tensión entre poder corporativo y poder de democratización del espacio radioeléctrico a través de un análisis de la construcción de títulos y noticias en los diarios Clarín y Página/12 en el debate de audiencias públicas de la LSCA en la Cámara de Diputados, el día 8 de septiembre de 2009. El estudio recorre un corpus de 14 noticias, en las cuales observaremos la producción de los encuadres (volantas, títulos y bajadas y su correspondencia con los cuerpos o textos. El abordaje teórico apunta a problematizar la relación: medios y política articulando las categorías de Eliseo Verón para el análisis de la prensa y su propuesta conceptual sobre la enunciación política. [en] Our research addresses the discursive modes adopted by two of the main national newspapers—Clarín and Pá- gina/12—on the occasion of one of the most stressing moments of the relation between concentrated mass media and Cristina Fernández de Kirchner’s administration: the debate over the Law of Audiovisual Communication Services (LSCA, in Spanish. Our research seeks to establish criteria for the conceptual specification of the political field as related to the communication field. It tackles the tension between corporative and democratic power over the radio space by analyzing the headlines and news in Clarín and Página/12 during the LSCA public hearings in The House

Synthesis and in vitro cytotoxicity of novel C-12 substituted-14-deoxy-andrographolide derivatives as potent anti-cancer agents.

Science.gov (United States)

Kandanur, Sai Giridhar Sarma; Golakoti, Nageswara Rao; Nanduri, Srinivas

2015-12-15

Andrographolide, the major labdane diterpenoid from Andrographis paniculata has been reported to be cytotoxic against various cancer cells in vitro. Our research efforts led to the discovery of novel 12-phenyl thio and 12-aryl amino-14-deoxy-andrographolide derivatives (III q and III r) with potent cytotoxic activity, 12-benzyl amino-14-deoxy-andrographolide analogues showing broad range of cytotoxic activity against most of the cell lines and 12-alkyl amino-14-deoxy-andrographolide derivatives being selective to few cell lines (PC-3 and HOP-92), when the selected analogues were evaluated against 60 human cancer cell line panel at National Cancer Institute (N.C.I.), USA. The SAR (structure activity relationship) studies demonstrated potent activity for the compounds containing the following functionalities at C-12: substituted aryl amino/phenyl thio>benzylamine>alkyl amine. The significant cytotoxic activity observed for compounds III q and III r suggest that these could serve as templates for further optimization. Copyright © 2015 Elsevier Ltd. All rights reserved.

LA Sprouts: A 12-Week Gardening, Nutrition, and Cooking Randomized Control Trial Improves Determinants of Dietary Behaviors.

Science.gov (United States)

Davis, Jaimie N; Martinez, Lauren C; Spruijt-Metz, Donna; Gatto, Nicole M

2016-01-01

To evaluate the effect of an exploratory 12-week nutrition, cooking, and gardening trial (LA Sprouts) on preference for fruit and vegetables (FV); willingness to try FV; identification of FV; self-efficacy to garden, eat, and cook FV; motivation to garden, eat, and cook FV; attitudes toward FV; nutrition and gardening knowledge; and home gardening habits. Randomized controlled trial. Four elementary schools. Three hundred four predominately Hispanic/Latino third- through fifth-grade students were randomized to either the LA Sprouts group (n = 167 students) or control group (n = 137 students). Twelve-week after-school nutrition, cooking, and gardening intervention. Determinants of dietary behavior as measured by questionnaire at baseline and postintervention. Analyses of covariance. After the 12-week program, compared with controls, LA Sprouts participants improved scores for identification of vegetables (+11% vs +5%; P = .001) and nutrition and gardening knowledge (+14.5% vs -5.0%; P = .003), and were more likely to garden at home (+7.5% vs -4.4%; P = .003). The LA Sprouts program positively affected a number of determinants of dietary behaviors that suggest possible mechanisms by which gardening and nutrition education act to improve dietary intake and health outcomes. Copyright © 2016 Society for Nutrition Education and Behavior. Published by Elsevier Inc. All rights reserved.

High-Pressure Synthesis, Structure, and Magnetic Properties of Ge-Substituted Filled Skutterudite Compounds; LnxCo4Sb12−yGey, Ln = La, Ce, Pr, and Nd

Directory of Open Access Journals (Sweden)

Hiroshi Fukuoka

2017-12-01

Full Text Available A series of new Ge-substituted skutterudite compounds with the general composition of LnxCo4Sb12−yGey, where Ln = La, Ce, Pr, and Nd, is prepared by high-pressure and high-temperature reactions at 7 GPa and 800 °C. They have a cubic unit cell and the lattice constant for each compound is 8.9504 (3, 8.94481 (6, 8.9458 (3, and 8.9509 (4 Å for the La, Ce, Pr, and Nd derivatives, respectively. Their chemical compositions, determined by electron prove microanalysis, are La0.57Co4Sb10.1Ge2.38, Ce0.99Co4Sb9.65Ge2.51, Pr0.97Co4Sb9.52Ge2.61, and Nd0.87Co4Sb9.94Ge2.28. Their structural parameters are refined by Rietveld analysis. The guest atom size does not affect the unit cell volume. The Co–Sb/Ge distance mainly determines the unit cell size as well as the size of guest atom site. The valence state of lanthanide ions is 3+.

Segadora Vietnamita GRH-1.2, nueva tecnología en la producción de arroz popular.

Directory of Open Access Journals (Sweden)

Ridelmis Rodríguez Hernández

2007-03-01

Full Text Available El trabajo se realizó en 9.54 hectáreas (ha en los municipios de La Sierpe, Fomento y Jatibonico, así como en la Estación Experimental del Arroz “Sur del Jíbaro”, todo en la provincia de Sancti Spíritus. Para ello se utilizó la segadora manual GRH - 1.2, la que dispone de tracción en sus dos ruedas de jaula, con sistema de corte con cuchillas y transmisión por cadenas, así como unos dedos plásticos que trasladan el arroz cortado hasta depositarlo en el suelo hacia el lado posterior derecho de este equipo. Los resultados de esta validación mostraron la eficiencia de la segadora en la cosecha del arroz, al ser comparada con el corte tradicional con hoz, pues en este último caso resulta más costosa la tarea, al ser necesario el empleo de 16 hombres, con un gasto de 186.75 pesos (MN por encima del correspondiente al primero. Debe señalarse que el corte con segadora resultó más uniforme, además de tener una aceptación muy positiva por parte de especialistas y productores del Sector Popular.

Synthesis and Characterization of New Polyamides from 1,2-Bis hydrazine Derivatives

International Nuclear Information System (INIS)

Salaha, A.; Abdel-Bary, E.M.; Kandilea, N.G.

2005-01-01

Preparation of polyamides having different chemical structures allows obtaining new materials with different mechanical and physical properties. The difference in the chemical structure depends mainly on the starting reactants used in condensation polymerization of polyamides. In this paper the synthesis of new polyamides based on the condensation polymerization of 1,2- Bis(3-carboxyacryloyl or carboxybenzoyl) hydrazine derivatives and various diamines has been described. The polymers obtained were characterized using spectroscopic and X-ray analysis. Besides thermal stability and electrical conductivity have been evaluated and correlated with the chemical structure of the polyamides obtained

Photoinduced second harmonic generation of LaFe4Sb12near spin fluctuated critical points

International Nuclear Information System (INIS)

Nouneh, K.; Viennois, R.; Kityk, I.V.; Terki, F.; Charar, S.; Benet, S.; Paschen, S.

2004-01-01

The temperature dependence of the resistivity, the Seebeck coefficient and photoinduced second harmonic generation (PISHG) are studied near the quantum critical point in the skutterudite compound LaFe 4 Sb 12 , possessing increased spin fluctuations. We observed a large maximum of the PISHG at a temperature of about 15 K. The PISHG signal increases substantially below 35 K. We found a correlation between the temperature dependences of PISHG, resistivity and Seebeck coefficient. We proposed a phenomenological explanation for the occurrence of the PISHG signal in LaFe 4 Sb 12 implying strong spin fluctuations exist in this system, which may present some interest for the study of other spin fluctuation systems. Physical insight into the phenomenon observed is grounded in the participation of anharmonic electron-phonon and electron-paramagnon interactions stimulated by inducing light in the interactions with the photoexcited dipole moments. (copyright 2004 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

Synthesis and Cytotoxic Effect of Some Novel 1,2-Dihydropyridin-3-carbonitrile and Nicotinonitrile Derivatives

Directory of Open Access Journals (Sweden)

Eman M. Flefel

2015-12-01

Full Text Available 1-(2,4-Dichlorophenyl-3-(4-fluorophenylpropen-1-one (1 was prepared and reacted with an active methylene compound (ethyl cyanoacetate in the presence of ammonium acetate to give the corresponding cyanopyridone 2. Compound 2 reacted with hydrazine hydrate, malononitrile, ethyl bromoacetate and phosphorous oxychloride to afford compounds 4 and 7–11, respectively. The 2-chloropyridine derivative 11 reacted with different primary amines, namely benzyl amine, piperonyl amine, 1-phenylethyl amine, and/or the secondary amines 2-methyl-pipridine and morpholine to give the corresponding derivatives 12–15. Hydrazinolysis of chloropyridine derivative 11 with hydrazine hydrate afforded the corresponding hydrazino derivative 17. Condensation of compound 17 with ethyl acetoacetate, acetylacetone, isatin and different aldehydes gave the corresponding derivatives 18–21. Some of newly synthesized compounds were screened for cytotoxic activity against three tumor cell lines. The results indicated that compounds 8 and 16 showed the best results, exhibiting the highest inhibitory effects towards the three tumor cell lines, which were higher than that of the reference doxorubicin and these compounds were non-cytotoxic towards normal cells (IC50 values > 100 μg/mL.

An ab-initio investigation on SrLa intermetallic compound

Science.gov (United States)

Kumar, S. Ramesh; Jaiganesh, G.; Jayalakshmi, V.

2018-05-01

The electronic, elastic and thermodynamic property of CsCl-type SrLa are investigated through density functional theory. The energy-volume relation for this compound has been obtained. The band structure, density of states and charge density in (110) plane are also examined. The elastic constants (C11, C12 and C44) of SrLa is computed, then, using these elastic constants, the bulk moduli, shear moduli, Young's moduli and Poisson's ratio are also derived. The calculated results showed that CsCl-type SrLa is ductile at ambient conditions. The thermodynamic quantities such as free energy, entropy and heat capacity as a function of temperature are estimated and the results obtained are discussed.

Comment on 'Pressure-induced changes in transport properties of layered La1.2Ca1.8Mn2O7'

International Nuclear Information System (INIS)

Ganguly, R.; Siruguri, V.; Gopalakrishnan, I.K.; Yakhmi, J.V.

2000-01-01

We show that the compound La 1.2 Ca 1.8 Mn 2 O 7 does not form with layered Sr 3 Ti 2 O 7 -type structure as reported by Kamenev et al. [Phys. Rev. B 56, R12 688 (1997)]. Detailed analysis of the powder x-ray diffraction pattern of this compound (synthesized by using the solid-state method) by Rietveld method shows that it forms a multiphase mixture comprising hole-doped perovskite manganates (La 1-x Ca x MnO 3 ) as the majority phases and CaO as the minority phase

Magnetotransport of CaCu3Mn4O12 complex perovskite derivatives

International Nuclear Information System (INIS)

Sanchez-Benitez, J.; Andres, A. de; Garcia-Hernandez, M.; Alonso, J.A.; Martinez-Lope, M.J.

2006-01-01

Neutron powder diffraction, magnetic and magnetotransport studies were carried out on new derivatives of the CaCu 3 Mn 4 O 12 (A'A 3 B 4 O 12 ) complex perovskite. The samples were prepared in polycrystalline form under moderate pressure conditions. Substitutions at A and A' sites of CaCu 3 Mn 4 O 12 , with only Mn 4+ and insulating behavior, imply electron doping that affects the magnetic and transport properties. X-ray Absorption Spectroscopy showed that Mn 3+ /Mn 4+ valence mixing occurs only at B site, progressively filling the e g band and providing the metallic character in these compounds, as we observe in most of these samples. A semiconducting behavior is observed in samples with 50% Mn 3+ at B site. This can be understood by the opening of a gap in the conduction band corresponding to the half filling of the e g states. This is the case of the tetravalent rare earth doped samples (Ce and Th at A' site) and of the appropriate A site doped Ca(CuMn 2 )Mn 4 O 12 sample. At the strongly distorted A positions, Mn 3+ , with localized e g electrons, act as magnetic impurities at very low temperatures (<40 K) giving rise to the observed upturn in the resistivity. The magnetic origin of this scattering is evidenced by its drastic reduction under a magnetic field

Synthesis and evaluation of antimalarial activity of curcumin derivatives

International Nuclear Information System (INIS)

Gomes, Patricia Ramos; Miguel, Fabio Balbino; Almeida, Mauro Vieira de; Couri, Mara Rubia Costa; Oliveira, Michael Eder de; Ferreira, Vanessa Viana; Guimaraes, Daniel Silqueira Martins; Lima, Aline Brito de; Barbosa, Camila de Souza; Oliveira, Mariana Amorim de; Almeida, Mauro Vieira de; Viana, Gustavo Henrique Ribeiro; Varotti, Fernando de Pilla

2014-01-01

ne of the main challenges in the development of new antimalarial drugs is to achieve a viable lead candidate with good pharmacokinetic properties. Curcumin has a broad range of biological activities, including antimalarial activity. Herein, we report the antimalarial activity of six curcumin derivatives (6-12) and an initial analysis of their pharmacokinetic properties. Five compounds have demonstrated potent activity against the P. falciparum in vitro (IC 50 values ranging from 1.7 to 15.2 μg mL -1 ), with moderate or low cytotoxicity against the HeLa cell line. The substitution of the carbonyl group in 6 by a 2,4-dinitrophenylhydrazone group (to afford 11) increases the Selective Index. These preliminary results indicate curcumin derivatives as potential antimalarial compounds. (author)

Hexagonal perovskites with cationic vacancies. 23. Rhombohedral 12 L stacking polytypes of type Ba/sub 3/LaBsup(II)Resup(VII)Wsup(VI)vacantO/sub 12/ with Bsup(II) = Mg, Co, Ni, Cu, Zn

Energy Technology Data Exchange (ETDEWEB)

Herrmann, M; Kemmler-Sack, S [Tuebingen Univ. (Germany, F.R.). Lehrstuhl fuer Anorganische Chemie 2

1980-11-01

The rhombohedral 12 L pervoskites with cationic vacancies of type Ba/sub 3/LaBsup(II)ReWvacantO/sub 12/ with Bsup(II) = Mg, Co, Ni, Cu, Zn are isotypic. According to intensity calculations on powder patterns of Ba/sub 3/LaZnReWvacantO/sub 12/ the series crystallize in the space group R-3m with the sequence (hhcc)/sub 3/; the refined, intensity related R' value is 5.7%. The octahedral net consists of blocks of three face connected octahedra with central void (ReWvacantO/sub 12/ units), which are linked via common corners through single octahedra, occupied by zinc.

Patio 2.12: Vivienda prefabricada, sostenible, autosuficiente y energéticamente eficiente. Participación en la competición Solar Decathlon Europe 2012

Directory of Open Access Journals (Sweden)

Terrados-Cepeda, F. J.

2015-06-01

Full Text Available The prototype “Patio 2.12” was Andalucía Team’s proposal for the 2012 Solar Decathlon Competition (SDE 2012, that was held in Madrid during September 2012, where it was awarded several prizes like the first one in Energy Efficiency. The team comprised a group of teachers and students from four Andalusian Universities. It worked for two years in the design and construction of a housing prototype that could be an example of several concepts at the same time: energy efficiency, architectural integration of solar systems, intermediate scale of prefabrication and a today´s interpretation of traditional Mediterranean way of living and building. Patio 2.12 was intended to be a compendium of energy, sustainability and passive conditioning devices.El prototipo Patio 2.12 fue la propuesta del equipo Andalucía Team para la competición Solar Decathlon Europe 2012 (SDE 2012, celebrada en Madrid en septiembre de 2012, en la que recibió hasta 9 premios, entre los que figura el de Eficiencia Energética. El equipo, integrado por profesores y alumnos de cuatro universidades andaluzas, trabajó durante dos años en el diseño y construcción de un prototipo de vivienda basada en la eficiencia energética, en la integración arquitectónica de los sistemas solares, en la prefabricación de escala intermedia y en una reinterpretación de la forma de vivir y construir de la tradición mediterránea. Patio 2.12 pretende ser un compendio de energía, sostenibilidad y mecanismos de acondicionamiento pasivo.

Influencia del tamaño del balón y la altura de la canasta en la eficacia del lanzamiento en categoría pre-infantil (11-12 años femenina.[Influence of ball size and basket height in the effectiveness of the shooting in femalepre-child level (11-12 years

Directory of Open Access Journals (Sweden)

María Teresa Gutiérrez Colón

2010-03-01

Full Text Available Resumen El objetivo de este estudio es conocer cuáles son las mejores condiciones de aprendizaje del lanzamiento a canasta en baloncesto en la etapa pre-infantil. En esta etapa existe un cambio brusco para el niño en función del tamaño del equipamiento, que exige realizar un proceso de adaptación progresivo de las dimensiones del balón y de la canasta, permitiendo que los jugadores tengan un aprendizaje más adecuado y adaptado a sus características. La muestra estuvo formada por 12 jugadoras pre-infantiles (11-12 años, pertenecientes a un equipo de baloncesto femenino. Se analizó la eficacia de los lanzamientos a canasta en función del tamaño del balón y la altura de la canasta, así como de la posición del lanzamiento, antes y después de un proceso de intervención. Los resultados mostraron que al inicio del proceso existían diferencias en la eficacia de los lanzamientos. Las jugadoras eran más eficaces lanzando con balón minibasket (numero 5 y canasta de minibasket que con los del juego adulto (numero 6. Finalmente, tras el proceso de intervención los resultados mostraron como las jugadoras aumentan su eficacia cuando lanzan con balón y canasta grande con respecto al inicio de la temporada. Además, en el pos-test obtuvieron mayores valores de eficacia con este material que con el balón y la canasta pequeña. Palabras clave: baloncesto, pre-infantil, eficacia, lanzamiento, tamaño de balón, altura de la canasta.Abstract The aim of this study is to know which are learning best conditions of the shooting basketball in the phase pre-child. In this phase is a sharp change for the boy depending on the size of the equipment, that demands to carry out a progressive adaptation process of dimensions of the ball and of the basket, allowing that players have a more suitable and adapted learning to his characteristics. The sample was formed by 12 players pre-child (11-12 years, belonging an equipment from feminine basketball. The

Suppression of aqueous corrosion of La(Fe0.88Si0.12)13 by reducing dissolved oxygen concentration for high-performance magnetic refrigeration

International Nuclear Information System (INIS)

Fujieda, S.; Fukamichi, K.; Suzuki, S.

2014-01-01

Highlights: • The aqueous corrosion of La(Fe 0.88 Si 0.12 ) 13 and its suppression were investigated. • The lattice expansion after immersion was caused by the hydrogen absorption. • The itinerant-electron metamagnetic transition became indistinct after immersion. • The aqueous corrosion was suppressed by reducing the dissolved oxygen concentration. - Abstract: The itinerant-electron metamagnetic transition of La(Fe 0.88 Si 0.12 ) 13 becomes indistinct after immersion in distilled-water containing about 8 ppm of the dissolved oxygen (DO) concentration because of aqueous corrosion. However, the aqueous corrosion of La(Fe 0.88 Si 0.12 ) 13 is significantly suppressed by reducing the DO concentration. Thus, isothermal magnetic entropy change after immersion for 30 days in deaerated distilled-water with a DO concentration less than 0.1 ppm is larger than that after immersion for 5 days in distilled-water containing about 8 ppm of the DO concentration. Consequently, the reduction of the DO concentration is effective for preservation of the excellent magnetocaloric effects of La(Fe 0.88 Si 0.12 ) 13 in an aqueous solution, which is a promising heat transfer fluid of room-temperature magnetic refrigeration

Assessment of stress tolerance acquisition in the heat-tolerant derivative strains of Bifidobacterium animalis subsp. lactis BB-12 and Lactobacillus rhamnosus GG.

Science.gov (United States)

Aakko, J; Sánchez, B; Gueimonde, M; Salminen, S

2014-07-01

The purpose of this study was to investigate the heat-shock response at molecular level in Lactobacillus rhamnosus GG, Bifidobacterium animalis subsp. lactis BB-12 and their heat-tolerant derivatives and to characterize the changes that make the derivatives more robust in terms of heat stress. The study strains were exposed for 2 h to a heat-shock treatment, Bif. animalis subsp. lactis BB-12 and its derivative at 50°C and the Lact. rhamnosus GG and its derivative at 60°C. Protein synthesis before and after heat shock was examined using proteomics and RT-qPCR. The analysis revealed that the regulation of seven proteins in both strain pairs was modified as a response to heat or between the original and the derivative strain. The comparison of wild-type strains and the heat-tolerant derivatives suggests that the acquisition of heat tolerance in the Bif. animalis subsp. lactis BB-12 derivative is due to a slightly increased constitutive level of chaperones, while in Lact. rhamnosus GG derivative, the main reason seems to be a higher ability to induce the production of chaperones. This study revealed possible markers of heat tolerance in B. lactis and Lact. rhamnosus strains. This study increases our knowledge on how Lactobacillus and Bifidobacterium strains may acquire heat tolerance. These findings may be useful for improving the heat tolerance of existing probiotic strains as well as screening new heat-tolerant strains. © 2014 The Society for Applied Microbiology.

Structural and electrical properties of Na{sub 1/2}La{sub 1/2}TiO{sub 3} ceramics

Energy Technology Data Exchange (ETDEWEB)

Barik, S K; Mahapatra, P K [Vidyasagar University, Department of Physics and Technophysics, Midnapur, West Bengal (India); Choudhary, R N.P. [Department of Physics and Meteorology, I.I.T. Kharagpur (India)

2006-11-15

Na{sub 1/2}La{sub 1/2}TiO{sub 3} (NLT) ceramic was prepared by a high-temperature solid-state reaction technique. A preliminary structural analysis (XRD) suggested the formation of a single-phase orthorhombic structure. SEM micrograph of the material showed uniform grain distribution on the surface of the sample. The dielectric permittivity and the loss tangent of the sample were measured in a frequency range from 1 kHz to 1 MHz and a temperature range 28 C to 525 C. Electrical properties of the material were studied using an ac impedance spectroscopic technique. Detailed analysis of the impedance spectrum suggested that the electrical properties of the material are strongly temperature dependant. The Nyquist plots clearly showed the presence of both bulk and grain boundary effect in the compound. The activation energy was estimated to be 1.1 eV from the temperature variation of dc conductivity. The a.c. conductivity spectrum suggests a typical signature of ion conducting system. (orig.)

New orthorhombic derivative of CaCu{sub 5}-type structure: RNi{sub 4}Si compounds (R=Y, La, Ce, Sm, Gd–Ho), crystal structure and some magnetic properties

Energy Technology Data Exchange (ETDEWEB)

Morozkin, A.V., E-mail: morozkin@general.chem.msu.ru [Department of Chemistry, Moscow State University, Leninskie Gory, House 1, Building 3, GSP-2, Moscow 119992 (Russian Federation); Knotko, A.V. [Department of Chemistry, Moscow State University, Leninskie Gory, House 1, Building 3, GSP-2, Moscow 119992 (Russian Federation); Yapaskurt, V.O. [Department of Petrology, Geological Faculty, Moscow State University, Leninskie Gory, Moscow 119992 (Russian Federation); Yuan, Fang; Mozharivskyj, Y. [Department of Chemistry and Chemical Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4M1 (Canada); Nirmala, R. [Indian Institute of Technology Madras, Chennai 600036 (India)

2013-12-15

The crystal structure of new YNi{sub 4}Si-type RNi{sub 4}Si (R=Y, La, Ce, Sm, Gd–Ho) compounds has been established using powder X-ray diffraction. The YNi{sub 4}Si structure is a new structure type, which is orthorhombic derivative of CaCu{sub 5}-type structure (space group Cmmm N 65, oC12). GdNi{sub 4}Si and DyNi{sub 4}Si compounds order ferromagnetically at 25 and 19 K, respectively whereas YNi{sub 4}Si shows antiferromagnetic nature. At 15 K, DyNi{sub 4}Si shows second antiferromagnetic-like transition. The magnetic moment of GdNi{sub 4}Si at 5 K in 50 kOe field is ∼7.2 μ{sub B}/f.u. suggesting a completely ordered ferromagnetic state. The magnetocaloric effect of GdNi{sub 4}Si is calculated in terms of isothermal magnetic entropy change and it reaches the maximum value of −12.8 J/kg K for a field change of 50 kOe near T{sub C} ∼25 K. - Graphical abstract: The RNi{sub 4}Si (R=Y, La, Ce, Sm, Gd–Ho) compounds crystallize in new YNi{sub 4}Si-type structure which is orthorhombic derivative of the basic CaCu{sub 5}-type structure. GdNi{sub 4}Si and DyNi{sub 4}Si compounds show the ferromagnetic-like ordering, whereas.YNi{sub 4}Si has the antiferromagnetic nature. The GdNi{sub 4}Si demonstrates the big magnetocaloric effect near temperature of ferromagnetic ordering. The relationship between initial CaCu{sub 5}-type DyNi{sub 5} and YNi{sub 4}Si-type DyNi{sub 4}Si lattices.

Detailed investigation of thermal and electron transport properties in strongly correlated compound Ce6Pd12In5 and its nonmagnetic analog La6Pd12In5

Science.gov (United States)

Falkowski, M.; Krychowski, D.; Strydom, A. M.

2016-11-01

An in-depth study of thermal and electron transport properties including thermal conductivity κ(T), thermoelectric power S(T), and electrical resistivity ρ(T) of the heavy fermion Kondo lattice Ce6Pd12In5 and its nonmagnetic reference compound La6Pd12In5 is presented. The absolute κ(T) value of Ce6Pd12In5 is smaller that than of La6Pd12In5, which indicates that conduction electron-4f electron scattering has a large impact on the reduction of thermal conductivity. The isolated 4f electron contributions to the electrical resistivity ρ 4 f (T), electronic thermal resistivity displayed in the form W e l , 4 f (T) .T, and thermoelectric power S 4 f (T) reveal a low- and high-temperature -lnT behaviour characteristic of Kondo systems with strong crystal-electric field (CEF) interactions. The analysis of phonon scattering processes of lattice thermal conductivity κph(T) in (Ce, La)6Pd12In5 was performed over the whole accessible temperature range according to the Callaway model. In the scope of a theoretical approach based on the perturbation type calculation, we were able to describe our experimental data of ρ 4 f (T) and W e l , 4 f (T) .T by using the model incorporating simultaneously the Kondo effect in the presence of the CEF splitting, as it is foreseen in the framework of the Cornut-Coqblin and Bhattacharjee-Coqblin theory. Considering the fact that there are not many cases of similar studies at all, we also show the numerical calculations of temperature-dependent behaviour of spin-disorder resistivity ρs(T), magnetic resistivity ρ 4 f (T), and occupation number ⟨ N i ⟩ due to the various types of degeneracy of the ground state multiplet of Ce 3 + (J = 5/2).

Hexagonal perovskites with cationic vacancies. 14. The rhombohedral 12 L-stacking polytypes Ba/sub 2/La/sub 2/Bsup(II)(W/sub 2/sup(VI)vacantO/sub 12/)

Energy Technology Data Exchange (ETDEWEB)

Kemmler-Sack, S [Tuebingen Univ. (Germany, F.R.). Lehrstuhl fuer Anorganische Chemie 2

1980-02-01

Rhombohedral 12 L-stacking polytypes with cationic vacancies of type Ba/sub 2/La/sub 2/Bsup(II)(W/sub 2/sup(VI)vacantO/sub 12/) are reported for Bsup(II) = Mg, Zn (white), Ni (light brown) and Co (brown). For Bsup(II) = Cu, as a consequence of the Jahn Teller effect, a triclinic distorted lattice is observed.

Synthesis, Characterization, DNA Interaction, and Antitumor Activities of La (III) Complex with Schiff Base Ligand Derived from Kaempferol and Diethylenetriamine.

Science.gov (United States)

Wang, Qin; Huang, Yu; Zhang, Jin-Sheng; Yang, Xin-Bin

2014-01-01

A novel La (III) complex, [LaL(H2O)3]NO3 ·3H2O, with Schiff base ligand L derived from kaempferol and diethylenetriamine, has been synthesized and characterized by elemental analysis, IR, UV-visible, (1)H NMR, thermogravimetric analysis, and molar conductance measurements. The fluorescence spectra, circular dichroism spectra, and viscosity measurements and gel electrophoresis experiments indicated that the ligand L and La (III) complex could bind to CT-DNA presumably via intercalative mode and the La (III) complex showed a stronger ability to bind and cleave DNA than the ligand L alone. The binding constants (K b ) were evaluated from fluorescence data and the values ranged from 0.454 to 0.659 × 10(5) L mol(-1) and 1.71 to 17.3 × 10(5) L mol(-1) for the ligand L and La (III) complex, respectively, in the temperature range of 298-310 K. It was also found that the fluorescence quenching mechanism of EB-DNA by ligand L and La (III) complex was a static quenching process. In comparison to free ligand L, La (III) complex exhibited enhanced cytotoxic activities against tested tumor cell lines HL-60 and HepG-2, which may correlate with the enhanced DNA binding and cleaving abilities of the La (III) complex.

Principales afecciones dentomaxilofaciales en estudiantes de 12 años de la Escuela Secundaria Básica Urbana "Antonio Maceo Grajales"

Directory of Open Access Journals (Sweden)

Zulema Chávez González

2015-04-01

Full Text Available Se realizó un estudio descriptivo y transversal de 84 estudiantes de 12 años de la Escuela Secundaria Básica Urbana "Antonio Maceo Grajales" de Santiago de Cuba, atendidos en la Clínica Estomatológica Provincial Docente "Mártires del Moncada" de esta ciudad, desde septiembre de 2012 hasta junio de 2013, para determinar las principales afecciones dentomaxilofaciales en ellos. Se tomaron en cuenta las variables: sexo, edad, factores de riesgo de las afecciones bucales, hábitos bucales deformantes (succión digital, lengua protráctil, respiración bucal y onicofagia; estados de la dentición, gingival y de la oclusión, clasificación epidemiológica, examen extrabucal y necesidad de tratamiento. En la casuística predominaron el sexo femenino, la higiene bucal deficiente, la dieta cariogénica y la onicofagia. Se concluyó que era indispensable elevar los conocimientos sobre salud bucal para prevenir afecciones estomatológicas

Derivation of an expression for the roundoff noise determinant det (KW)^{1/2} for digital filters

DEFF Research Database (Denmark)

Jørsboe, Helge

1978-01-01

The minimal roundoff noise in fixed point digital filters is determined by a certain determinant, generally denoted by det(KW)^{1/2}. This determinant may be expressed by the poles and zeros of the filter transfer function H(z). This paper presents a simple and direct derivation of this expression...

Multielectronic conduction in La1-xSrxGa1/2Mn1/2O3-δ as solid oxide fuel cell cathode

Science.gov (United States)

Iguchi, E.; Hashimoto, Y.; Kurumada, M.; Munakata, F.

2003-08-01

Four-probe dc conductivities, capacitances, and thermopower have been measured in the temperature range of 80-1123 K for La1-xSrxGa1/2Mn1/2O3-δ, which is a desirable cathode material for lanthanum-gallate electrolytes of solid oxide fuel cells. The dc conductivities in the specimens (0.1⩽x⩽0.3) are insensitive to x but the thermopower is very sensitive to x, although the x=0 specimen exhibits a somewhat different conduction behavior. At T500 K, the band conduction dominates the electronic transports. The ionic conduction due to O2- migration seems difficult to contribute directly to the dc conduction even at high temperature.

Li{sub 12}Cu{sub 12.60}Al{sub 14.37}. A new ternary derivative of the binary Laves phases

Energy Technology Data Exchange (ETDEWEB)

Pavlyuk, Volodymyr [Ivan Franko Lviv National Univ. (Ukraine). Dept. of Inorganic Chemistry; Jan Dlugosz Univ., Czestochowa (Poland). Inst. of Chemistry, Environment Protection and Biotechnology; Dmytriv, Grygoriy; Tarasiuk, Ivan [Ivan Franko Lviv National Univ. (Ukraine). Dept. of Inorganic Chemistry; Chumak, Ihor [IFW Dresden (Germany); Ehrenberg, Helmut [Karlsruhe Institute of Technology (KIT), Karlsruhe (Germany). Inorganic Chemistry

2011-12-15

New ternary dodecalithium dodecacopper tetradecaaluminium, Li{sub 12}Cu{sub 12.60}Al{sub 14.37} (trigonal, R anti 3m, hR39), crystallizes as a new structure type and belongs to the structural family that derives from binary Laves phases. The Li atoms are enclosed in 15- and 16-vertex and the Al3 atom in 14-vertex pseudo-Frank-Kasper polyhedra. The polyhedra around the statistical mixtures of (Cu,Al)1 and (Al,Cu)2 are distorted icosahedra. The electronic structure was calculated by the TB- LMTO-ASA (tight-binding linear muffin-tin orbital atomic spheres approximation) method. The electron localization function, which indicates bond formation, is mostly located at the Al atoms. Thus, Al-Al bonding is much stronger than Li-Al or Cu-Al bonding. This indicates that, besides metallic bonding which is dominant in this compound, weak covalent Al-Al interactions also exist. (orig.)

Adaptive synchronization of the complex dynamical network with non-derivative and derivative coupling

Energy Technology Data Exchange (ETDEWEB)

Xu Yuhua, E-mail: yuhuaxu2004@163.co [College of Information Science and Technology, Donghua University, Shanghai 201620 (China) and Department of Maths, Yunyang Teachers' College, Hubei 442000 (China); Zhou Wuneng, E-mail: wnzhou@163.co [College of Information Science and Technology, Donghua University, Shanghai 201620 (China); Fang Jian' an [College of Information Science and Technology, Donghua University, Shanghai 201620 (China); Sun Wen [School of Mathematics and Information, Yangtze University, Hubei Jingzhou 434023 (China)

2010-04-05

This Letter investigates the synchronization of a general complex dynamical network with non-derivative and derivative coupling. Based on LaSalle's invariance principle, adaptive synchronization criteria are obtained. Analytical result shows that under the designed adaptive controllers, a general complex dynamical network with non-derivative and derivative coupling can asymptotically synchronize to a given trajectory, and several useful criteria for synchronization are given. What is more, the coupling matrix is not assumed to be symmetric or irreducible. Finally, simulations results show the method is effective.

Prevalencia del déficit de vitamina B12 en mayores de 60 años hospitalizados. Estudio del polimorfismo C677T de la enzima 5-10 MTHFR en pacientes con déficit de vitamina B12

OpenAIRE

Alonso Ortiz, María Belén

2014-01-01

Programa de doctorado: Avances en Medicina Interna. [ES] El déficit de Vitamina B12 es frecuente en los pacientes mayores. Sin embargo, son escasos los trabajos realizados en el ámbito hospitalario. Este déficit se asocia frecuentemente con elevación de la homocisteína plasmática, conocido factor de riesgo cardiovascular. Además la mutación C677T del gen de la enzima MTHFR se relaciona con hiperhomocistenemia, que puede coexistir con déficit de Vitamina B12, cuya frecuencia y consecuencias...

Synthesis and crystal structures of 2-methyl-4-aryl-5-oxo-5H-indeno [1,2-b] pyridine carboxylate derivatives

DEFF Research Database (Denmark)

Pandian, Ramesh; Naushad, Edayadulla; Vijayakumar, Vinodhkumar

2014-01-01

pyridine derivatives through oxidation. Consequently, the interest in this aromatization reaction, investigation of a wide range of 1, 4-DHPs continues to attract the attention of researchers. Herein, we report the preparation of pyridine derivatives and the crystal structures determined by X......-ray crystallographic methods.Results: The crystal structures and conformational studies of two organic compounds, namely ethyl 2-methyl-4-phenyl-5-oxo-5H-indeno [1,2-b] pyridine-3-carboxylate (I) and ethyl 2-methyl-4-(4 chlorophenyl)-5-oxo-5H-indeno [1,2-b] pyridine-3-carboxylate (II) are reported. The terminal ethyl......) dimer running along 011 direction.Conclusion: The crystal structures ethyl 2-methyl-4-phenyl-5-oxo-5H-indeno [1,2-b] pyridine-3-carboxylate and ethyl 2-methyl-4-(4 chlorophenyl)-5-oxo-5H-indeno [1,2-b] pyridine-3-carboxylate have been investigated in detail. The terminal ethyl group of compound I...

Hablemos de la Influenza

Centers for Disease Control (CDC) Podcasts

2010-12-08

En la charla, un médico responde a las preguntas frecuentes sobre la vacuna contra la influenza (gripe).  Created: 12/8/2010 by Centro Nacional para la Inmunización y Enfermedades Respiratorias (NCIRD).   Date Released: 12/8/2010.

Composicion corporal y prevalencia estandarizada de desnutricion en niños de 6 a 12 años de edad, La Costa, Argentina

OpenAIRE

Bolzán,Andrés; Guimarey,Luis M.

2003-01-01

OBJETIVOS: evaluar la composición corporal y la prevalencia estandarizada de desnutrición en niños de seis a 12 años de edad de La Costa, Argentina. MÉTODOS: se midieron la estatura, perímetro braquial y el pliegue cutáneo tricipital, calculando los siguientes indicadores: circunferencia muscular braquial, área muscular braquial, área grasa braquial (AGB), índice área muscular braquial/estatura (AMBE), índice energía/proteína (EP) e índice grasa/músculo braquiales. Se calculó la prevalencia e...

LA-12 overcomes confluence-dependent resistance of HT-29 colon cancer cells to Pt (II) compounds

Czech Academy of Sciences Publication Activity Database

Šindlerová, Lenka; Foltinová, V.; Vaculová, Alena; Horváth, Viktor; Souček, Karel; Sova, P.; Hofmanová, Jiřina; Kozubík, Alois

2010-01-01

Roč. 30, č. 4 (2010), s. 1183-1188 ISSN 0250-7005 R&D Projects: GA ČR(CZ) GA301/07/1557 Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702 Keywords : LA-12 * resistance * HT-29 Subject RIV: BO - Biophysics Impact factor: 1.656, year: 2010

High stability of the goldalloy fullerenes: A density functional theory investigation of M12@Au20 (M = Na, Al, Ag, Sc, Y, La, Lu, and Au) clusters

International Nuclear Information System (INIS)

Zhang Meng; Feng Xiao-Juan; Zhao Li-Xia; Zhang Hong-Yu; Luo You-Hua

2012-01-01

Discovering highly stable metal fullerenes such as the celebrated C 60 is interesting in cluster science as they have potential applications as building blocks in new nanostructures. We here investigated the structural and electronic properties of the fullerenes M 12 @Au 20 (M = Na, Al, Ag, Sc, Y, La, Lu, and Au), using a first-principles investigation with the density functional theory. It is found that these compound clusters possess a similar cage structure to the icosahedral Au 32 fullerene. La 12 @Au 20 is found to be particularly stable among these clusters. The binding energy of La 12 @Au 20 is 3.43 eV per atom, 1.05 eV larger than that in Au 32 . The highest occupied molecular orbital-lowest unoccupied molecular orbital (HOMO-LUMO) gap of La 12 @Au 20 is only 0.31 eV, suggesting that it should be relatively chemically reactive. (condensed matter: structural, mechanical, and thermal properties)

The hematopoietic chemokine CXCL12 promotes integration of human endothelial colony forming cell-derived cells into immature vessel networks.

Science.gov (United States)

Newey, Sarah E; Tsaknakis, Grigorios; Khoo, Cheen P; Athanassopoulos, Thanassi; Camicia, Rosalba; Zhang, Youyi; Grabowska, Rita; Harris, Adrian L; Roubelakis, Maria G; Watt, Suzanne M

2014-11-15

Proangiogenic factors, vascular endothelial growth factor (VEGF), and fibroblast growth factor-2 (FGF-2) prime endothelial cells to respond to "hematopoietic" chemokines and cytokines by inducing/upregulating expression of the respective chemokine/cytokine receptors. Coculture of human endothelial colony forming cell (ECFC)-derived cells with human stromal cells in the presence of VEGF and FGF-2 for 14 days resulted in upregulation of the "hematopoietic" chemokine CXCL12 and its CXCR4 receptor by day 3 of coculture. Chronic exposure to the CXCR4 antagonist AMD3100 in this vasculo/angiogenesis assay significantly reduced vascular tubule formation, an observation recapitulated by delayed AMD3100 addition. While AMD3100 did not affect ECFC-derived cell proliferation, it did demonstrate a dual action. First, over the later stages of the 14-day cocultures, AMD3100 delayed tubule organization into maturing vessel networks, resulting in enhanced endothelial cell retraction and loss of complexity as defined by live cell imaging. Second, at earlier stages of cocultures, we observed that AMD3100 significantly inhibited the integration of exogenous ECFC-derived cells into established, but immature, vascular networks. Comparative proteome profiler array analyses of ECFC-derived cells treated with AMD3100 identified changes in expression of potential candidate molecules involved in adhesion and/or migration. Blocking antibodies to CD31, but not CD146 or CD166, reduced the ECFC-derived cell integration into these extant vascular networks. Thus, CXCL12 plays a key role not only in endothelial cell sensing and guidance, but also in promoting the integration of ECFC-derived cells into developing vascular networks.

Evaluación de la tolerancia a la crioconservación de dos cepas de Escherichia coli K12 de uso frecuente en biotecnología

Directory of Open Access Journals (Sweden)

Diliana Celeste Pérez-Reytor*, Angela Estela Sosa Espinosa

2010-08-01

Full Text Available Uno de los métodos más recomendados para la conservación de E. coli es la congelación entre -20ºC y -70ºC, donde comúnmente se utiliza glicerol o dimetilsulfóxido como criopreservante. Los bancos de E. coli que se conservan por esta vía pueden mantener altas viabilidades por más de 10 años. A pesar de que es una práctica común están poco documentadas las diferencias que existen entre las cepas de interés biotecnológico en cuanto a la resistencia a la congelación. En este artículo se comparan dos cepas mutantes de E. coli K12: la cepa RRI y la cepa HB101, con el objetivo de evaluar el comportamiento de ambas a dos temperaturas de almacenamiento y diferentes concentraciones de glicerol, después de ocho ciclos sucesivos de congelación-descongelación. Las cepas estudiadas sólo difieren en su capacidad de reparación al daño sobre el ADN al presentar la HB101 una variante mutada del gen recA. Cuando se utilizó una temperatura de almacenamiento de -70 ºC y diferentes concentraciones de criopreservante las cepas tuvieron un comportamiento similar de supervivencia, después de los ocho ciclos. Sin embargo, el comportamiento de la supervivencia difiere cuando la temperatura de congelación en los ciclos es de -20 ºC. Además de la supervivencia y la estabilidad de los marcadores genéticos estudiados, observamos que el efecto de los ciclos de congelación y descongelación retardó el tiempo de aparición de las colonias en medio sólido.

The solubility and site preference of Fe{sup 3+} in Li{sub 7−3x}Fe{sub x}La{sub 3}Zr{sub 2}O{sub 12} garnets

Energy Technology Data Exchange (ETDEWEB)

Rettenwander, D., E-mail: daniel.rettenwander@sbg.ac.at [Department of Materials Research and Physics, University of Salzburg, 5020 Salzburg (Austria); Geiger, C.A. [Department of Materials Research and Physics, University of Salzburg, 5020 Salzburg (Austria); Tribus, M.; Tropper, P. [Institute of Mineralogy and Petrography, Faculty of Geo- and Atmospheric Sciences, University of Innsbruck, Innrain 52, 6020 Innsbruck (Austria); Wagner, R.; Tippelt, G.; Lottermoser, W.; Amthauer, G. [Department of Materials Research and Physics, University of Salzburg, 5020 Salzburg (Austria)

2015-10-15

A series of Fe{sup 3+}-bearing Li{sub 7}La{sub 3}Zr{sub 2}O{sub 12} (LLZO) garnets was synthesized using solid-state synthesis methods. The synthetic products were characterized compositionally using electron microprobe analysis and inductively coupled plasma optical emission spectroscopy (ICP-OES) and structurally using X-ray powder diffraction and {sup 57}Fe Mössbauer spectroscopy. A maximum of about 0.25 Fe{sup 3+} pfu could be incorporated in Li{sub 7−3x}Fe{sub x}La{sub 3}Zr{sub 2}O{sub 12} garnet solid solutions. At Fe{sup 3+} concentrations lower than about 0.16 pfu, both tetragonal and cubic garnets were obtained in the synthesis experiments. X-ray powder diffraction analysis showed only a garnet phase for syntheses with starting materials having intended Fe{sup 3+} contents lower than 0.52 Fe{sup 3+} pfu. Back-scattered electron images made with an electron microprobe also showed no phase other than garnet for these compositions. The lattice parameter, a{sub 0}, for all solid-solution garnets is similar with a value of a{sub 0}≈12.98 Å regardless of the amount of Fe{sup 3+}. {sup 57}Fe Mössbauer spectroscopic measurements indicate the presence of poorly- or nano-crystalline FeLaO{sub 3} in syntheses with Fe{sup 3+} contents greater than 0.16 Fe{sup 3+} pfu. The composition of different phase pure Li{sub 7−3x}Fe{sub x}La{sub 3}Zr{sub 2}O{sub 12} garnets, as determined by electron microprobe (Fe, La, Zr) and ICP-OES (Li) measurements, give Li{sub 6.89}Fe{sub 0.03}La{sub 3.05}Zr{sub 2.01}O{sub 12}, Li{sub 6.66}Fe{sub 0.06}La{sub 3.06}Zr{sub 2.01}O{sub 12}, Li{sub 6.54}Fe{sub 0.12}La{sub 3.01}Zr{sub 1.98}O{sub 12}, and Li{sub 6.19}Fe{sub 0.19}La{sub 3.02}Zr{sub 2.04}O{sub 12}. The {sup 57}Fe Mössbauer spectrum of cubic Li{sub 6.54}Fe{sub 0.12}La{sub 3.01}Zr{sub 1.98}O{sub 12} garnet indicates that most Fe{sup 3+} occurs at the special crystallographic 24d position, which is the standard tetrahedrally coordinated site in garnet. Fe{sup 3+} in smaller

Enzyme Inhibitory Radicinol Derivative from Endophytic fungus Bipolaris sorokiniana LK12, Associated with Rhazya stricta

Directory of Open Access Journals (Sweden)

Abdul Latif Khan

2015-07-01

Full Text Available Endophytes, living inside plant tissues, play an essential role in plant growth and development, whilst producing unique bioactive secondary metabolites. In the current study, the endophytic fungus Bipolaris sorokiniana LK12 was isolated from the leaves of ethno-medicinal and alkaloidal rich Rhazya stricta. The bulk amount of ethyl acetate extract of fungus was subjected to advance column chromatographic techniques, which resulted in the isolation of a new radicinol derivative, bipolarisenol (1. It was found to be a derivative of radicinol. The structure elucidation was carried out by the combined use of 1D and 2D nuclear magnetic resonance, infrared spectroscopy, mass, and UV spectrometric analyses. The bipolarisenol was assessed for its potential role in enzyme inhibition of urease and acetyl cholinesterase (AChE. Results showed that bipolarisenol significantly inhibited the AChE activity with low IC50 (67.23 ± 5.12 µg·mL−1. Bipolarisenol inhibited urease in a dose-dependent manner with high IC50 (81.62 ± 4.61 µg·mL−1. The new compound also showed a moderate anti-lipid peroxidation potential (IC50 = 168.91 ± 4.23 µg·mL−1. In conclusion, endophytes isolated from medicinal plants possess a unique potential to be considered for future drug discovery.

The dynamics of some oxidative stress markers in 3, 6 and 12-months alcohol abstinent patients: possible relevance for the usage of antioxidants in alcohol withdrawal / Dinamica unor markeri ai stresului oxidativ la 3, 6 şi 12 luni de abstinenţă de la alcool: posibila relevanţă a utilizării de antioxidanţi

Directory of Open Access Journals (Sweden)

Petrariu Florin

2014-12-01

Full Text Available În prezentul articol am fost interesaţi să studiem relevanţa stresului oxidativ în cadrul proceselor legate de abstinenţa de la alcool, având în vedere în special faptul că literatura de specialitate este extrem de controversată în acest domeniu de cercetare. Astfel, am determinat nivelul unor markeri specifici ai stresului oxidativ la pacienţii selectaţi după 3, 6 şi 12 luni de abstinenţă de la alcool. 62 de pacienţi de sex masculin au fost selectaţi pentru studiu. În cadrul studiului s-au prezentat 33 de pacienţi pentru determinările bazale, 14 pacienţi la 3 luni, 14 pacienţi la 6 luni şi 15 pacienţi la 12 luni de abstinenţa de la alcool, în timp ce lotul control a inclus 32 de persoane sănătoase, potrivite ca vârstă si sex-ratio cu celelalte grupuri de studiu. Astfel, în ceea ce priveşte rezultatele, în cazul superoxid dismutazei (SOD am observat o diferenţă semnificativă între cele trei loturi de studiu (p<0.0001, precum şi o creştere semnificativă din punct de vedere statistic a valorilor SOD la pacienţii aflaţi la 3 luni (p<0.0001, 6 luni (p<0.0001 şi respectiv 12 luni (p<0.0001 de abstinenţa de la alcool, faţă de determinările bazale. De asemenea, în cazul glutation peroxidazei, am observat o diferenţă semnificativă din punct de vedere statistic între grupuri (p=0.0003, plus creşteri importante la 6 luni (p=0.03 şi 12 luni (p=0.006, faţă de determinările bazale. În ceea ce priveşte malondialdehida (MDA, ca şi principal marker al proceselor de peroxidare lipidică, am putut observa de asemenea diferenţe semnificative între grupurile de studiu (p<0.0001. Mai mult, în cazul tuturor celor 3 grupe de pacienţi s-au putut observa scăderi semnificative ale concentraţiei de MDA, în comparaţie cu determinările bazale (p=0.003 pentru 3 luni, p=0.01 pentru 6 luni şi p=0.0002 pentru 12 luni. În concluzie, aceste date confirmă un stress oxidativ crescut la pacienţii consumatori

Magnon Broadening Effects in Double Layered Manganite La_1.2 Sr_1.8 Mn_2 O_7

OpenAIRE

Furukawa, Nobuo; Hirota, Kazuma

1999-01-01

Magnon linewidth of La_1.2 Sr_1.8 Mn_2 O_7 near the Brillouin zone boundary is investigated from both theoretical and experimental points of view. Abrupt magnon broadening is ascribed to a strong magnon-phonon coupling. Magnon broadening observed in cubic perovskite manganites is also discussed.

Respuesta de anticuerpos inducidos por la vacuna antimeningocócica cubana VA-MENGOC-BC® frente a la cepa de Neisseria meningitidis B:4:P1.19,15 en adolescentes después de 12 años de inmunizados

Directory of Open Access Journals (Sweden)

María A. Camaraza

2006-12-01

Full Text Available Se estudió la respuesta de anticuerpos inducida por la vacuna antimeningocócica cubana VA-MENGOC-BC® contra la cepa de Neisseria meningitidis B:4:P1.19,15 mediante el Ensayo Bactericida del Suero (EBS y ELISA de tipo indirecto, para medir anticuerpos contra vesículas de membrana externa (VME de N. meningitidis B a 184 adolescentes de un politécnico de Ciego de Ávila que fueron inmunizados en campañas masivas 12 años antes. Se realizaron extracciones de sangre antes de aplicar la primera dosis (T0, 4 semanas después de ésta (T1 y 4 semanas después de la segunda dosis (T2. Transcurridos 12 años de esta vacunación el 42% de los adolescentes presentó títulos bactericidas ≥ 1:4 frente a la cepa homóloga (B:4:P1.19,15 y el 98% mostró anticuerpos detectables contra las VME. En el EBS; el porcentaje de seroconversión T1/T0 fue del 57% y T2/T0 del 60%. Mediante ELISA la seroconversión fue del 59% y 54%, respectivamente, por lo que se demostró que la aplicación de una sola dosis después de 12 años indujo una respuesta inmune importante que puede sugerir una respuesta anamnésica.

Influencia de la preparación física en el dominio técnico futbolista 12-14 años del Club el Nacional

OpenAIRE

Alomoto Navarrete, Rocío

2014-01-01

Siendo conocedores de la realidad deportiva ecuatoriana en la formación de deportistas en diferentes etápas sabiendo que en la étapa de inciación deportiva el aprendizaje de la técnica deportiva depende de una buena preparación física es importante analizar la influencia de la preparación física en el dominio técnico de futbolista 12-14 años así como su influencia en el dominio técnico de este deporte. El objetivo es proponer una programa de ejercicios para la influencia de la preparación fís...

Platinum(IV) complex LA-12 exerts higher ability than cisplatin to enhance TRAIL-induced cancer cell apoptosis via stimulation of mitochondrial pathway

Czech Academy of Sciences Publication Activity Database

Jelínková, Iva; Šafaříková, Barbora; Blanářová, Olga; Skender, Belma; Hofmanová, Jiřina; Sova, P.; Moyer, M.P.; Kozubík, Alois; Kolář, Z.; Ehrmann, J.; Vaculová, Alena

2014-01-01

Roč. 92, č. 3 (2014), s. 415-424 ISSN 0006-2952 R&D Projects: GA MŠk(CZ) ED1.100/02/0123 Institutional support: RVO:68081707 Keywords : IN-VITRO * C-MYC * CHEMOTHERAPEUTIC DRUGS Subject RIV: BO - Biophysics Impact factor: 5.009, year: 2014

Suplementación de ácido fólico con o sin vitamina B12 para prevenir el deterioro cognitivo en sujetos de edad avanzada: análisis crítico de la literatura

Directory of Open Access Journals (Sweden)

Raúl Alberto Aguilera-Eguía

2016-01-01

Full Text Available La demencia es un síndrome que interfiere en funciones corticales de la persona, posiblemente causado por déficit de vitamina B12. Se cree que la suplementación de ácido fólico con o sin vitamina B12 puede prevenir el deterioro cognitivo o disminuirlo en sujetos sanos de edad avanzada que presentan altos niveles de homocisteína en plasma. El objetivo de este trabajo fue comprobar la validez y aplicabilidad de los resultados con respecto a la efectividad de la suplementación de ácido fólico con o sin vitamina B12 en sujetos de edad avanzada con niveles elevados de homocisteína y responder al siguiente interrogante: en sujetos sanos de edad avanzada con niveles altos de homocisteína, ¿puede la suplementación de ácido fólico con o sin vitamina B12 prevenir o disminuir el deterioro de las funciones cognitivas? Se analizó la revisión sistemática Cochrane “Ácido fólico con o sin vitamina B12 para la prevención y el tratamiento de personas sanas de edad avanzada con demencia”, de Malouf et al. (2008. La administración de ácido fólico por tres años con o sin vitamina B12 en sujetos sanos de edad avanzada con un alto nivel de homocisteína en plasma, podrían mejorar significativamente la función cognitiva global, presentando una diferencia media ponderada de 0,05 (IC 95%; 0,004 a 0,096. A pesar de las limitaciones metodológicas y la escasa cantidad de estudios primarios incluidos en la revisión sistemática analizada, encontramos razonable el uso de ácido fólico con o sin vitamina B12 para mejorar la función cognitiva en personas sanas de edad avanzada con niveles elevados de homocisteína.

Synthesis of novel 4,6-di(substituted)amino-1,2-dihydro-1,3,5-triazine derivatives as topical antiseptic agents.

Science.gov (United States)

Maeda, Shirou; Kita, Toshiko; Meguro, Kanji

2009-02-12

A series of novel 4,6-di(substituted)amino-1,2-dihydro-1,3,5-triazine derivatives designed to have ClogP of 5.1-7.5 was synthesized and evaluated for their antiseptic properties by MIC and MBC tests against Gram-positive and Gram-negative bacteria, including MRSA, VRE, and P. aeruginosa. Among these compounds, 4-alkyl-6-aralkyl derivatives having ClogP of 6.6-7.1 and 4-alkyl-6-aryl or 4,6-dialkyl derivatives with ClogP of 6.0-6.4 showed pronounced antibacterial activities in both tests.

Factores Intrinsecos asociados a la Maloclusión Dentaria en Estudiantes de 12 a 16 años de edad en la Institución Educativa Secundaria Comercial N°45 Puno-2015

OpenAIRE

Atencio Apomayta, Mercedes Ayde

2015-01-01

El presente trabajo de investigación titulado “Factores intrínsecos asociados a la Maloclusión dentaria en estudiantes de 12 a 16 años de edad en la Institución Educativa Secundaria comercial Nº 45 Puno - 2015”, cuya problemática principal es: ¿Cuáles son los factores intrínsecos asociados a la mal oclusión dentaria?, mientras que el objetivo principal fue: Determinar los factores intrínsecos asociados a la maloclusión dentaria, y como hipótesis se planteó: Los factores intrínsecos están dire...

Morbilidad de la extracción de los terceros molares en pacientes entre los 12 y 18 años de edad

OpenAIRE

Chaparro Avendaño, Angie Virginia; Pérez García, Silvia; Valmaseda Castellón, E.; Berini Aytés, Leonardo; Gay Escoda, Cosme

2005-01-01

Objetivo: El propósito de este estudio fue analizar la incidencia de complicaciones después de la extracción quirúrgica de los terceros molares en pacientes de 12 a 18 años de edad. Pacientes y método: Se realizó un estudio retrospectivo de 390 extracciones quirúgicas de terceros molares superiores e inferiores en 173 pacientes en edades comprendidas entre los 12 y 18 años de edad, intervenidos bajo anestesia locorregional en el año 2000 en el Máster de Cirugía Bucal e Im...

12. Consommations alimentaires liées à la mondialisation

OpenAIRE

Russel, Marie; Esnouf, Catherine

2017-01-01

Pour qu’une alimentation soit durable, elle doit protéger la biodiversité et les écosystèmes, être acceptable culturellement, accessible économiquement, loyale, sûre, bonne pour la santé, et optimiser l’usage des ressources naturelles et humaines. La durabilité de l’alimentation est mise à l’épreuve face à un environnement de plus en plus incertain : croissance démographique, urbanisation, changement climatique, raréfaction et qualité des ressources naturelles, augmentation du prix du carbone...

The position of imidazopyridine and metabolic activation are pivotal factors in the antimutagenic activity of novel imidazo[1,2-a]pyridine derivatives.

Science.gov (United States)

El-Sayed, Wael M; Hussin, Warda A; Al-Faiyz, Yasair S; Ismail, Mohamed A

2013-09-05

The antimutagenic activity of eight novel imidazo[1,2-a]pyridine derivatives (I-VIII) against sodium azide (NaN3) and benzo[a]pyrene (B[a]P) was evaluated using the Salmonella reverse mutation assay. At non-toxic concentrations (12.5-50 µM), imidazopyridines I, II, III, and V with a terminal imidazopyridine group were mutagenic, while derivatives VII and VIII with a central imidazopyridine group were not mutagenic. Compounds IV, VII, and VIII exerted a moderate antimutagenic activity against NaN3 under pre-exposure conditions, and a strong activity (>40%) against B[a]P in the presence of S9 under both pre- and co-exposure conditions and mostly independent on the dose. Imidazopyridines possibly inhibited the microsomal-dependent activation of B[a]P. The demethylated derivative VII was the most active antimutagen. All imidazopyridines had a low to moderate antioxidant activity. The antibacterial activity of imidazopyridines was sporadic and moderate probably due to the failure of bacteria to convert imidazopyridines into active metabolites. The position of imidazopyridine was a pivotal factor in the mutagenic/antimutagenic activity. The strong antimutagenic compounds were dicationic planar compounds with a centered imidazo[1,2-a]pyridine spacer. With LD50 of 60 mg/kg in mice for both derivatives VII and VIII, it is safe to investigate the anticancer activity of these derivatives in animal models. © 2013 Elsevier B.V. All rights reserved.

Efectos de la Respuesta del Lector y del Uso de Ejemplos sobre la Composición Escrita

Directory of Open Access Journals (Sweden)

Virginia Pacheco

2013-01-01

Full Text Available Se evaluó el papel de la respuesta del lector y del uso de ejemplos en la elaboración de procedimientos de un escritor en estudiantes universitarios, en dos sesiones: en la primera 36 escritores describieron una figura y una ruta en un mapa; en la segunda, los escritores fueron distribuidos en tres grupos: DM: 12 escritores modificaron sus descripciones con base en ejemplos de procedimientos similares y en dibujos elaborados por 12 lectores; D: 12 escritores modificaron sus textos con base en dibujos de 12 lectores y SDSM: 12 escritores hicieron modificaciones sin ver dibujos ni ejemplos. Los grupos DM y D hicieron descripciones más precisas. Se discute la relevancia de analizar las interacciones escritoras en función del propósito y la complejidad de la tarea.

La memoria y su gestión en la etapa de 6 a 12 años

OpenAIRE

Merino Pérez, Raúl

2014-01-01

La memoria es una de las capacidades más importantes en el desarrollo de las personas, y por lo tanto, es factor determinante en el desarrollo de los niños. El aprendizaje y la memoria son dos términos que van inevitablemente de la mano. El trabajo pretende profundizar en el conocimiento que se tiene acerca de la memoria e intentar relacionarlo con la etapa de Educación Primaria. La primera parte del trabajo nos servirá para conocer el concepto de memoria y su funcionamiento, según los ...

Novel NSAID-Derived Drugs for the Potential Treatment of Alzheimer’s Disease

Directory of Open Access Journals (Sweden)

Ivana Cacciatore

2016-06-01

Full Text Available Nonsteroidal anti-inflammatory drugs (NSAIDs have been suggested for the potential treatment of neurodegenerative diseases, such as Alzheimer’s disease (AD. Prolonged use of NSAIDs, however, produces gastrointestinal (GI toxicity. To overcome this serious limitation, the aim of this study was to develop novel NSAID-derived drug conjugates (Anti-inflammatory-Lipoyl derivatives, AL4–9 that preserve the beneficial effects of NSAIDS without causing GI problems. As such, we conjugated selected well-known NSAIDs, such as (S-naproxen and (R-flurbiprofen, with (R-α-lipoic acid (LA through alkylene diamine linkers. The selection of the antioxidant LA was based on the proposed role of oxidative stress in the development and/or progression of AD. Our exploratory studies revealed that AL7 containing the diaminoethylene linker between (R-flurbiprofen and LA had the most favorable chemical and in vitro enzymatic stability profiles among the synthesized compounds. Upon pretreatment, this compound exhibited excellent antioxidant activity in phorbol 12-miristate 13-acetate (PMA-stimulated U937 cells (lymphoblast lung from human and Aβ(25–35-treated THP-1 cells (leukemic monocytes. Furthermore, AL7 also modulated the expression of COX-2, IL-1β and TNF-α in these cell lines, suggesting anti-inflammatory activity. Taken together, AL7 has emerged as a potential lead worthy of further characterization and testing in suitable in vivo models of AD.

Efecto del derivado de la lactosa sobre la población microbiana de muestras fecales de cerdos posdestete

Directory of Open Access Journals (Sweden)

Rosero Olga Lucía

2006-03-01

Full Text Available COMPENDIO Se estudió el efecto prebiótico del derivado de la lactosa (DL en la población microbiana presente en las muestras de heces (inóculo fecal de los cerdos posdestete. Se utilizó la técnica de producción de gas in vitro en 2 sustratos: el control pulpa de remolacha (PR y DL. Se desarrollaron dos etapas. En la primera se determinó la producción del gas y las proporciones de ácidos grasos volátiles (AGV, evaluando la actividad microbiana en los niveles (0, 0.2, 2, 20 y 100% de DL reemplazando a la PR, durante la fermentación de 144h. El tiempo medio de la producción del gas potencial se alcanzó a las 12h de la fermentación. Este tiempo se utilizó para la segunda etapa con tres niveles de DL (0, 20 y 100%. Se determinó el efecto del DL sobre la composición de la población microbiana (E. coli, lactobacillus y anaerobios facultativos totales, concentración de AGV y sobre el pH, como resultado de la fermentación bacteriana . Se incrementó la concentración del butirato (P < 0.001 y la acidificación (P < 0.001 del medio. El DL modificó la composición microbiana, que se reflejó en la disminución (P < 0.001 del número de colonias microbianas de E. coli. En conclusión el DL en niveles altos presentó efectos prebióticos. Palabras claves: Lactosa, prebiótico, fermentación in vitro, cerdo, butirato, Escherichia coli ABSTRACT Effect of Lactose Derivative (LD on the present microbial populationʼs in the sample faeces of weaned piglets The pre­biotic effect of Lactose Derivative (LD on the present microbial populationʼs in the sample faeces (faecal inocula of weaned piglets was studied . The in vitro gas-production technique was used. Using 2 substrates: sugarbeet pulp (SBP as control and LD as evaluation. Two stages were developed. In the first it the gas production and the Volatile Fatty Acids (VFA proportions, during 144h fermentation, to evaluate the effect of the microbial activity with different

Progesterone radioimmunoassay with the use of progesterone derivative substituted at 12α position

International Nuclear Information System (INIS)

Kula, E.; Stupnicka, R.

1981-01-01

A direct (non-extraction) radioimmunoassay method for progesterone determination in blood plasma has been presented. A new progesterone derivative substituted at 12α position was used as antigen for production of antibody. Cheap and easily accessible substrate -deoxycholic acid - was used as starting material for 9 step degradation procedure yielding 12α-hydroxy-progesterone. The latter compound was subsequently esterified with succinic anhydrine and conjugated with bovine serum albumin. The conjugate was then used for the immunization of rabbits to obtain immune antisera. After the detailed characterization, the obtained antibodies have been used for the determination of progesterone in human and cattle blood plasma. Transcortin present in samples used for the determinations was saturated with the excess of cortisol. The sensitivity of the method was found to be 5 pg in a sample, which corresponds to the concentration of about 0.25 ng/ml in blood plasma, in as much as the volume of plasma used for analysis was 20 ml. The within-series error was 7% when progesterone concentration in plasma samples was higher than 2.5 ng/ml. (author)

High effectiveness of novel platinum derivative with adamantylamine LA-12 and possible mechanisms of its action

Czech Academy of Sciences Publication Activity Database

Kozubík, Alois; Horváth, Viktor; Šindlerová, Lenka; Souček, Karel; Vondráček, Jan; Sova, P.; Hofmanová, Jiřina

2006-01-01

Roč. 18, č. 1 (2006), S51-S51 ISSN 1107-3756. [The 11th World Congress on Advances in Oncology and 9th International Symposium on Molecular Medicine . 12.10.2006-14.10.2006, Hersonissos] R&D Projects: GA AV ČR(CZ) 1QS500040507 Institutional research plan: CEZ:AV0Z50040507 Keywords : ovarian cancer * cisplatin * cell cycle Subject RIV: BO - Biophysics

Synthesis of pyrido[1,2-a]benzimidazoles and other fused imidazole derivatives with a bridgehead nitrogen atom

Science.gov (United States)

Begunov, Roman S.; Ryzvanovich, Galina A.

2013-01-01

Main methods for the synthesis of fused imidazole derivatives with a bridgehead nitrogen atom are systematically considered and summarized. The reaction mechanisms that underlie the methods for the synthesis of pyrido[1,2-a]benzimidazoles and related compounds are described. Biological properties and mechanisms of the biological activity of fused azaheterocycles are discussed. The bibliography includes 152 references.

Magneto-optical properties BaBi{sub x}La{sub x}Fe{sub 12−2x}O{sub 19} (0.0≤x≤0.5) hexaferrites

Energy Technology Data Exchange (ETDEWEB)

Auwal, I.A. [Department of Chemistry, Fatih University, 34500 B.Çekmece, İstanbul (Turkey); Baykal, A., E-mail: hbaykal@fatih.edu.tr [Department of Chemistry, Fatih University, 34500 B.Çekmece, İstanbul (Turkey); Güner, S. [Department of Physics, Fatih University, 34500 B.Çekmece, İstanbul (Turkey); Sertkol, M. [Department of Physics Engineering, Istanbul Technical University, 34469 Maslak, Istanbul (Turkey); Sözeri, H. [TUBITAK-UME, National Metrology Institute, P.O. Box 54, 41470 Gebze, Kocaeli (Turkey)

2016-07-01

BaBi{sub x}La{sub x}Fe{sub (12−2x)}O{sub 19} (0.0≤x≤0.5) hexaferrites were synthesized by solid state synthesis route and the effects of Bi, La substitutions on structural, magnetic and optical properties were investigated. X-ray powder diffraction, Scanning electron microscopy, Vibrating sample magnetometer, and Percent diffuse reflectance spectroscopy were used to study the physical properties. Room temperature specific magnetization (M–H) curves revealed the ferromagnetic nature of all products. The increasing Bi, La compositions increased the magnetic properties at different magnitudes with respect to undoped BaFe{sub 12}O{sub 19} sample. The maximum values of remnant specific magnetization (M{sub r}=30.3 emu/g), extrapolated specific saturation magnetization (M{sub s}=62.12 emu/g), and magneton number (n{sub B}=16.27) were recorded from BaBi{sub 0.2}La{sub 0.2}Fe{sub 11.4}O{sub 19} hexaferrite. The average crystallite size varies in a range of (37.35–51.36) nm. The coercive field (H{sub c}) of undoped hexaferrites is 1180 Oe and increased to maximum 2320 Oe belonging to BaBi{sub 0.4}La{sub 0.4}Fe{sub 11.2}O{sub 19}. Magnetic anisotropy was confirmed as uniaxial and calculated effective anisotropy constants (K{sub eff}) are between 4.27×10{sup 5} Ergs/g and 5.05×10{sup 5} Ergs/g. The high magnitudes of magnetocrystalline anisotropy (H{sub a}) above than 16,200 Oe revealed that all samples are magnetically hard materials. The Tauc plots were drawn to extrapolate the direct optical energy band gap (E{sub g}) of hexaferrites. The E{sub g} values decreased from 1.76 eV to 1.47 eV with increasing Bi, La compositions. - Highlights: • BaBi{sub x}La{sub x}Fe{sub (12−2x)}O{sub 19} (0.0≤x≤0.5) hexaferrites were synthesized by solid state synthesis route. • The E{sub g} values decreased from 1.76 eV to 1.47 eV with increasing Bi, La compositions. • BaBi{sub xx}La{sub xx}Fe{sub 12-2x}O{sub 19} hexaferrites good candidate for potential applications

Synthesis, properties, crystal structures, and semiconductor characteristics of naphtho[1,2-b:5,6-b']dithiophene and -diselenophene derivatives.

Science.gov (United States)

Shinamura, Shoji; Miyazaki, Eigo; Takimiya, Kazuo

2010-02-19

In this paper we present the synthesis, structures, characterization, and applications to field-effect transistors (FETs) of naphtho[1,2-b:5,6-b']dithiophene (NDT) and -diselenophene (NDS) derivatives. Treatment of 1,5-dichloro-2,6-diethynylnaphthalenes, easily derived from commercially available 2,6-dihydroxynaphthalene, with sodium chalcogenide afforded a straightforward access to NDTs and NDSs including the parent and dioctyl and diphenyl derivatives. Physicochemical evaluations of NDT and NDS derivatives showed that these heteroarenes have a similar electronic structure with isomeric [1]benzothieno[2,3-b][1]benzothiophene (BTBT) and [1]benzoselenopheneno[2,3-b][1]benzoselenophene (BSBS) derivatives, respectively. Although attempts to fabricate solution-processed field-effect transistors (FETs) with soluble dioctyl-NDT (C(8)-NDT) and -NDS (C(8)-NDS) failed, diphenyl derivatives (DPh-NDT and DPh-NDS) afforded vapor-processed FETs showing field-effect mobility as high as 0.7 cm(2) V(-1) s(-1). These results indicated that NDT and NDS are new potential heteroarene core structures for organic semiconducting materials.

Direct catalytic conversion of brown seaweed-derived alginic acid to furfural using 12-tungstophosphoric acid catalyst in tetrahydrofuran/water co-solvent

International Nuclear Information System (INIS)

Park, Geonu; Jeon, Wonjin; Ban, Chunghyeon; Woo, Hee Chul; Kim, Do Heui

2016-01-01

Highlights: • Furfural was produced by catalytic conversion of macroalgae-derived alginic acid. • 12-Tungstophosphoric acid (H_3PW_1_2O_4_0) showed remarkable catalytic performance. • Tetrahydrofuran (THF) as a reaction medium significantly enhanced production of furfural. - Abstract: Furfural, a biomass-derived platform chemical, was produced by acid-catalyzed reaction of alginic acid extracted from brown seaweed. Three acid catalysts, H_2SO_4, Amberlyst15 and 12-tungstophosphoric acid (H_3PW_1_2O_4_0), were compared to evaluate their catalytic performance for the alginic acid conversion. The H_3PW_1_2O_4_0 catalyst showed the highest catalytic activity, yielding the maximum furfural yield (33.8%) at 180 °C for 30 min in tetrahydrofuran/water co-solvent. Higher reaction temperature promoted the conversion of alginic acid to furfural, but the transformation of furfural to humin was also accelerated. To our knowledge, this is the highest furfural yield among studies about the direct catalytic conversion of alginic acid. Furthermore, products distribution with time-on-stream was investigated in detail, which led us to propose a reaction pathway.

La Edad Biológica en la Preparación Física de las Atletas de Baloncesto Categoría 11-12 años de la EIDE Ormani Arenado de Pinar del Río

Directory of Open Access Journals (Sweden)

Abel Castillo López

2009-03-01

Full Text Available Este trabajo es el resultado de un largo y minucioso proceso investigativo encaminado  al estudio del proceso del entrenamiento y su relación con la edad biológica de las atletas escolares de baloncesto femenino, para perfeccionar el proceso de preparación física del deportista y contar con un criterio científico y preciso para el entrenamiento deportivo en las edades tempranas. Se apoya en un conjunto de métodos científicos teóricos y empíricos, dentro de los teóricos el Análisis-Síntesis, Inductivo-Deductivo, Histórico-Lógico y entre los empíricos: la entrevista y la medición, todo ello encaminado al diagnóstico, la sistematización de los conceptos más actualizados a que tuvimos acceso sobre el tema y en los resultados finales  que derivaron en la propuesta de un conjunto de acciones. Se empleó una muestra de 25 atletas, 5 entrenadores de Baloncesto, 2 Médicos Deportivos  y  3  Directivos  de  las  comisiones  provinciales  a  los  cuales  se  le aplicaron los diferentes métodos empleados. Los resultados se procesaron estadísticamente por el método  matemático de análisis porcentual y se determinaron estadígrafos tales como la media y la  desviación Standard. Como resultado se proponen un conjunto de acciones que permiten la incorporación del criterio de la edad biológica en la preparación física de las atletas de baloncesto de la categoría 11-12 años femenino.

Microencapsulation and Fermentation of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12

Directory of Open Access Journals (Sweden)

Maryam Yari

2015-09-01

Full Text Available Because of poor survival of probiotic bacteria, microencapsulation evolved from the immobilized cell culture technology used in the biotechnological industry. Two probiotic strains, Bifidobacterium (BB-12 and Lactobacillus acidophilus (LA-5 were immobilized in calcium alginate by extrusion method. Encapsulation parameters and efficacy of this method were evaluated. Growth factors of these two bacteria were also measured by culturing in 10-L fermenter. Growth curves were obtained with respect to optical density and dry biomass weight. Encapsulation yield was over than 60% in each experiment. Scanning electron microscopy (SEM of Entrapment of cells in alginate matrix and cross-sections of dried bead were obtained and illustrated. Bifidobacterium have been shown better biotechnological properties.

Prevalence of mild serum vitamin B12 deficiency in rural and urban Costa Rican young adults Prevalencia de la deficiencia moderada de vitamina B12 sérica en jóvenes adultos de zonas rurales y urbanas de Costa Rica

Directory of Open Access Journals (Sweden)

Ileana Holst-Schumacher

2007-12-01

Full Text Available OBJECTIVE: Recent studies have shown an increase of mild serum cobalamin (vitamin B12 deficiency in some Latin American countries; however, no data are available from Costa Rica. The purpose of this work was to establish the prevalence of serum vitamin B12 deficiency among Costa Rican young adults and to study some factors that may help explain the serum cobalamin concentrations. METHODS: A cross-sectional survey was conducted among 400 adults aged 20 to 40 years old from urban and rural areas of the central valley of Costa Rica to determine serum vitamin B12 levels. Additionally, cobalamin dietary intake and the detection of Helicobacter pylori IgG antibodies were studied as possible determinants of the serum vitamin B12 concentrations. RESULTS: The mean serum concentration of vitamin B12 was 268 ± 125 pmol/L, and no significant differences were found by gender or area. Study data indicate an overall prevalence of inadequate serum cobalamin levels of 42.4% (11.2% deficient and 31.2% marginal; more than 50% but less than 75% of individuals had an intake of vitamin B12 below the U.S. Estimated Average Requirement (EAR and 61.2% had IgG antibodies to H. pylori. CONCLUSIONS: The prevalence of mild serum vitamin B12 deficiency in young Costa Rican subjects is as high as in other Latin American countries. More investigation should be done to elucidate the etiological factors that are generating deficient and marginal serum cobalamin levels in Costa Rican adults in order to define appropriate public health actions.OBJETIVO: Aunque estudios recientes han demostrado un incremento en el déficit moderado de cobalamina (vitamina B12 sérica en algunos países de América Latina, no hay datos de Costa Rica. El propósito de este trabajo fue determinar la prevalencia de la deficiencia de vitamina B12 sérica en jóvenes adultos de Costa Rica y estudiar algunos factores que pueden ayudar a explicar las concentraciones séricas de cobalamina. MÉTODOS: Se

Preparation of Ce- and La-Doped Li4Ti5O12 Nanosheets and Their Electrochemical Performance in Li Half Cell and Li4Ti5O12/LiFePO4 Full Cell Batteries

Directory of Open Access Journals (Sweden)

Meng Qin

2017-06-01

Full Text Available This work reports on the synthesis of rare earth-doped Li4Ti5O12 nanosheets with high electrochemical performance as anode material both in Li half and Li4Ti5O12/LiFePO4 full cell batteries. Through the combination of decreasing the particle size and doping by rare earth atoms (Ce and La, Ce and La doped Li4Ti5O12 nanosheets show the excellent electrochemical performance in terms of high specific capacity, good cycling stability and excellent rate performance in half cells. Notably, the Ce-doped Li4Ti5O12 shows good electrochemical performance as anode in a full cell which LiFePO4 was used as cathode. The superior electrochemical performance can be attributed to doping as well as the nanosized particle, which facilitates transportation of the lithium ion and electron transportation. This research shows that the rare earth doped Li4Ti5O12 nanosheets can be suitable as a high rate performance anode material in lithium-ion batteries.

Preparation of Ce- and La-Doped Li4Ti5O12 Nanosheets and Their Electrochemical Performance in Li Half Cell and Li4Ti5O12/LiFePO4 Full Cell Batteries

Science.gov (United States)

Qin, Meng; Li, Yueming; Lv, Xiao-Jun

2017-01-01

This work reports on the synthesis of rare earth-doped Li4Ti5O12 nanosheets with high electrochemical performance as anode material both in Li half and Li4Ti5O12/LiFePO4 full cell batteries. Through the combination of decreasing the particle size and doping by rare earth atoms (Ce and La), Ce and La doped Li4Ti5O12 nanosheets show the excellent electrochemical performance in terms of high specific capacity, good cycling stability and excellent rate performance in half cells. Notably, the Ce-doped Li4Ti5O12 shows good electrochemical performance as anode in a full cell which LiFePO4 was used as cathode. The superior electrochemical performance can be attributed to doping as well as the nanosized particle, which facilitates transportation of the lithium ion and electron transportation. This research shows that the rare earth doped Li4Ti5O12 nanosheets can be suitable as a high rate performance anode material in lithium-ion batteries. PMID:28632167

Suppression of aqueous corrosion of La(Fe{sub 0.88}Si{sub 0.12}){sub 13} by reducing dissolved oxygen concentration for high-performance magnetic refrigeration

Energy Technology Data Exchange (ETDEWEB)

Fujieda, S., E-mail: fujieda@tagen.tohoku.ac.jp; Fukamichi, K.; Suzuki, S.

2014-07-05

Highlights: • The aqueous corrosion of La(Fe{sub 0.88}Si{sub 0.12}){sub 13} and its suppression were investigated. • The lattice expansion after immersion was caused by the hydrogen absorption. • The itinerant-electron metamagnetic transition became indistinct after immersion. • The aqueous corrosion was suppressed by reducing the dissolved oxygen concentration. - Abstract: The itinerant-electron metamagnetic transition of La(Fe{sub 0.88}Si{sub 0.12}){sub 13} becomes indistinct after immersion in distilled-water containing about 8 ppm of the dissolved oxygen (DO) concentration because of aqueous corrosion. However, the aqueous corrosion of La(Fe{sub 0.88}Si{sub 0.12}){sub 13} is significantly suppressed by reducing the DO concentration. Thus, isothermal magnetic entropy change after immersion for 30 days in deaerated distilled-water with a DO concentration less than 0.1 ppm is larger than that after immersion for 5 days in distilled-water containing about 8 ppm of the DO concentration. Consequently, the reduction of the DO concentration is effective for preservation of the excellent magnetocaloric effects of La(Fe{sub 0.88}Si{sub 0.12}){sub 13} in an aqueous solution, which is a promising heat transfer fluid of room-temperature magnetic refrigeration.

Apple derived cellulose scaffolds for 3D mammalian cell culture.

Directory of Open Access Journals (Sweden)

Daniel J Modulevsky

Full Text Available There are numerous approaches for producing natural and synthetic 3D scaffolds that support the proliferation of mammalian cells. 3D scaffolds better represent the natural cellular microenvironment and have many potential applications in vitro and in vivo. Here, we demonstrate that 3D cellulose scaffolds produced by decellularizing apple hypanthium tissue can be employed for in vitro 3D culture of NIH3T3 fibroblasts, mouse C2C12 muscle myoblasts and human HeLa epithelial cells. We show that these cells can adhere, invade and proliferate in the cellulose scaffolds. In addition, biochemical functionalization or chemical cross-linking can be employed to control the surface biochemistry and/or mechanical properties of the scaffold. The cells retain high viability even after 12 continuous weeks of culture and can achieve cell densities comparable with other natural and synthetic scaffold materials. Apple derived cellulose scaffolds are easily produced, inexpensive and originate from a renewable source. Taken together, these results demonstrate that naturally derived cellulose scaffolds offer a complementary approach to existing techniques for the in vitro culture of mammalian cells in a 3D environment.

Cancer cells cause vascular endothelial cell (vEC) retraction via 12(S)HETE secretion; the possible role of cancer cell derived microparticle.

Science.gov (United States)

Uchide, Keiji; Sakon, Masato; Ariyoshi, Hideo; Nakamori, Syouji; Tokunaga, Masaru; Monden, Morito

2007-02-01

Cancer cell mediated vascular endothelial cell (vEC) retraction plays a pivotal role in cancer metastasis. The aim of this study is to clarify the biochemical character of vEC retraction factor derived from human breast cancer cell line, MCF-7. In order to estimate vEC retracting activity, transwell chamber assay system was employed. We first tested the effects of trypsin digestion as well as lipid extraction of culture medium (CM). Trypsin digestion of CM resulted in approximately 40% loss of vEC retracting activity and lipid extraction of CM by Brigh and Dyer methods recovered approximately 60% of vEC retracting activity, suggesting that approximately 60% of vEC retracting activity in MCF-7 derived CM is due to lipid. Although Nordihydroguaiaretic acid (NDGA), the specific lipoxygenase inhibitor, suppressed vEC retracting activity in CM, Acetyl salicylic acid (ASA), a specific cyclooxygenase inhibitor, did not affect the activity, suggesting that lipid exerting vEC retracting activity in CM belongs to lipoxygenase mediated arachidonate metabolites. Thin layer chromatography clearly demonstrated that Rf value of lipid vEC retracting factor in CM is identical to 12HETE. Authentic 12(S)HETE, but not 12(R)HETE, showed vEC retracting activity. After the ultracentrifugation of CM, most lipid vEC retracting activity was recovered from the pellet fraction, and flow cytometric analysis using specific antibody against 12(S)HETE clearly showed the association of 12(S)HETE with small particle in CM. These findings suggested the principal involvement of 12(S)HETE in cancer cell derived microparticles in cancer cell mediated vEC retraction.

La evolución de la autoestima en la Enseñanza Primaria y su relación con el rendimiento

Directory of Open Access Journals (Sweden)

Francisco MATEOS CLAROS

2009-11-01

Full Text Available RESUMEN: Este trabajo, parte de una investigación sobre la autoestima, tiene como objetivo analizar los cambios evolutivos en la autoestima y estudiar las relaciones entre las dimensiones de ésta y el rendimiento escolar. La muestra está constituida por 503 sujetos de 7 a 12 años. Se utilizó un cuestionario construido expresamente para la investigación basado en cuatro dimensiones, singularidad, vinculación, poder y modelos. Los resultados indican el carácter evolutivo de la autoestima. Las dimensiones que más peso tienen en todas las edades son la singularidad y la vinculación y menos la sensación de poder y la presencia de modelos. Siguiendo el desarrollo de estas dimensiones se pudo elaborar el perfil evolutivo de la autoestima. La regresión múltiple identifica como dimensiones predictoras del rendimiento la singularidad, en todas las edades excepto en el tramo de 10-11 años que lo hace la presencia de modelos, y la sensación de poder, que tampoco está presente en el tramo de 11-12 años que es sustituida por la vinculación.ABSTRACT: This work, is a part of a investigation about the self-respect, the objetive is to analyze the evolution change in the self respect and study the relations between the dimension of this and the scholastic efficiency. The test consists in different test about 503 people between 7-12 years old. Used a questionnarie made expressly for the investigation based in four dimensions, singularity, linking, power and pattern. The result shows the evolution character of self-respect. The strongest point of the dimension in all the ages are singularity and the linking and a little less sensation of power and the presence of models. Following the growing of these dimensions we could made the evolutive profile of the self respect. The multiple regresión identify how forecast dimension of the scholastic the singularity in all the ages except between 10-11 years old that made the presence of the models and the

Demencia por déficit de vitamina B12: reporte de caso

OpenAIRE

Junco Bonet, Miguel Damián

2014-01-01

Fundamento: la deficiencia de vitamina B12 (cianocobalamina) puede producir varios desórdenes neurológicos, incluida la neuropatía periférica, degeneración subaguda combinada de la médula espinal, neuropatía óptica y alteraciones cognitivas que van desde la confusión leve hasta la demencia o la psicosis. La causa más frecuente de deficiencia de vitamina B12 es la anemia perniciosa. Objetivo: presentar un caso clínico de demencia por déficit de vitamina B12. Caso clínico: paciente masculino de...

Evaluation of the stability, bioavailability, and hypersensitivity of the omega-3 derived anti-leukemic prostaglandin: Δ(12-prostaglandin J3.

Directory of Open Access Journals (Sweden)

Avinash K Kudva

Full Text Available Previous studies have demonstrated the ability of an eicosapentaenoic acid (EPA-derived endogenous cyclopentenone prostaglandin (CyPG metabolite, Δ(12-PGJ3, to selectively target leukemic stem cells, but not the normal hematopoietic stems cells, in in vitro and in vivo models of chronic myelogenous leukemia (CML. Here we evaluated the stability, bioavailability, and hypersensitivity of Δ(12-PGJ3. The stability of Δ(12-PGJ3 was evaluated under simulated conditions using artificial gastric and intestinal juice. The bioavailability of Δ(12-PGJ3 in systemic circulation was demonstrated upon intraperitoneal injection into mice by LC-MS/MS. Δ(12-PGJ3 being a downstream metabolite of PGD3 was tested in vitro using primary mouse bone marrow-derived mast cells (BMMCs and in vivo mouse models for airway hypersensitivity. ZK118182, a synthetic PG analog with potent PGD2 receptor (DP-agonist activity and a drug candidate in current clinical trials, was used for toxicological comparison. Δ(12-PGJ3 was relatively more stable in simulated gastric juice than in simulated intestinal juice that followed first-order kinetics of degradation. Intraperitoneal injection into mice revealed that Δ(12-PGJ3 was bioavailable and well absorbed into systemic circulation with a Cmax of 263 µg/L at 12 h. Treatment of BMMCs with ZK118182 for 12 h resulted in increased production of histamine, while Δ(12-PGJ3 did not induce degranulation in BMMCs nor increase histamine. In addition, in vivo testing for hypersensitivity in mice showed that ZK118182 induces higher airways hyperresponsiveness when compared Δ(12-PGJ3 and/or PBS control. Based on the stability studies, our data indicates that intraperitoneal route of administration of Δ(12-PGJ3 was favorable than oral administration to achieve effective pharmacological levels in the plasma against leukemia. Δ(12-PGJ3 failed to increase histamine and IL-4 in BMMCs, which is in agreement with reduced airway

Variabilidad de la frecuencia cardíaca como indicador de salud en el deporte: validación con un cuestionario de calidad de vida (SF-12)

OpenAIRE

Capdevila Ortís, Lluís; Rodas Font, Gil; Ocaña Mariné, Marta; Parrado Romero, Eva; Pintanel Bassets, Mónica; Valero Herreros, Montserrat

2008-01-01

Introducción y objetivo: El análisis de la variabilidad de la frecuencia cardíaca (VFC) se utiliza cada vez más en el ámbito de la medicina del deporte para evaluar la adaptación al entrenamiento de los deportistas. Nuestro objetivo es validar el análisis de la VFC como indicador de salud, comparando los parámetros de VFC con las puntuaciones del SF-12 en una muestra de personas sanas. Método: Estudio experimental con 32 sujetos sanos, 18 varones y 14 mujeres (26,19 años de promedio). Se util...

Matrix metalloproteinase-12 gene regulation by a PPAR alpha agonist in human monocyte-derived macrophages

International Nuclear Information System (INIS)

Souissi, Imen Jguirim; Billiet, Ludivine; Cuaz-Perolin, Clarisse; Slimane, Mohamed-Naceur; Rouis, Mustapha

2008-01-01

MMP-12, a macrophage-specific matrix metalloproteinase with large substrate specificity, has been reported to be highly expressed in mice, rabbits and human atherosclerotic lesions. Increased MMP-12 from inflammatory macrophages is associated with several degenerative diseases such as atherosclerosis. In this manuscript, we show that IL-1β, a proinflammatory cytokine found in atherosclerotic plaques, increases both mRNA and protein levels of MMP-12 in human monocyte-derived macrophages (HMDM). Since peroxisome proliferator-activated receptors (PPARs), such as PPARα and PPARγ, are expressed in macrophages and because PPAR activation exerts an anti-inflammatory effect on vascular cells, we have investigated the effect of PPARα and γ isoforms on MMP-12 regulation in HMDM. Our results show that MMP-12 expression (mRNA and protein) is down regulated in IL-1β-treated macrophages only in the presence of a specific PPARα agonist, GW647, in a dose-dependent manner. In contrast, this inhibitory effect was abolished in IL-1β-stimulated peritoneal macrophages isolated from PPARα -/- mice and treated with the PPARα agonist, GW647. Moreover, reporter gene transfection experiments using different MMP-12 promoter constructs showed a reduction of the promoter activities by ∼ 50% in IL-1β-stimulated PPARα-pre-treated cells. However, MMP-12 promoter analysis did not reveal the presence of a PPRE response element. The IL-1β effect is known to be mediated through the AP-1 binding site. Mutation of the AP-1 site, located at - 81 in the MMP-12 promoter region relative to the transcription start site, followed by transfection analysis, gel shift and ChIP experiments revealed that the inhibitory effect was the consequence of the protein-protein interaction between GW 647-activated PPARα and c-Fos or c-Jun transcription factors, leading to inhibition of their binding to the AP-1 motif. These studies suggest that PPARα agonists may be used therapeutically, not only for lipid

La Tumba del Elefante de la Necrópolis Romana de Carmona. Una revisión necesaria desde la Arqueología de la Arquitectura y la Arqueoastronomía

Directory of Open Access Journals (Sweden)

Jiménez Hernández, Alejandro

2012-12-01

Full Text Available We present a review of the Tomb of the Elephant at the Roman Necropolis of Carmona (Sevilla made under the methodological principles of Building Archaeology and Archaeoastronomy. The results show that the building had several phases of use and was built to be a mithraeum as indicate its form and symbolism derived from the archaeoastronomical analysis of the window solar orientation.Presentamos una revisión de la Tumba del Elefante en la Necrópolis Romana de Carmona (Sevilla realizada bajo principios metodológicos de la Arqueología de la Arquitectura y la Arqueoastronomía. Los resultados obtenidos muestran que el edificio tuvo varias fases de uso y que fue construido para albergar un mitreo como indican su forma y la simbología derivada del análisis arqueoastronómico de la orientación solar de la ventana.

Transport and magnetic properties of CezLa1-zFe4Sb12

International Nuclear Information System (INIS)

Viennois, R; Charar, S; Ravot, D; Mauger, A; Haen, P; Tedenac, J C

2006-01-01

Transport and magnetic properties of Ce z La 1-z Fe 4 Sb 12 have been investigated in the whole range of substitution 0 Ce to the resistivity goes through a maximum at temperature ∼ 140K, close to the spin fluctuation temperature T sf for CeFe 4 Sb 12 . T sf is the single magnetic energy scale which accounts for the magnetic properties of the Ce Kondo lattice. At low temperature, the resistivity shows a T 2 -deviation from saturation. At z≤0.7 this is the behaviour expected for Ce impurities in metals in the Kondo limit. At z = 1, however, Hall effect measurements show that this behaviour is due to a decrease of the free carrier concentration which we can attribute to the formation of a hybridization pseudogap E g ∼ 25 meV. Upon dilution of the cerium, E g decreases and this pseudogap is smeared out, replaced by the Kondo resonance at the Fermi level characteristic of Kondo impurities in the small z limit

Cross sections for 12C+12C→12C(0+2)+12C(g.s.) using breathing mode doorways

International Nuclear Information System (INIS)

Ahmed, M.U.; Beres, W.P.

1982-01-01

A previously derived projection operator method is applied to the calculation of the cross section for 12 C+ 12 C→ 12 C(0 + 2 )+ 12 C(g.s.) with a breathing mode model being used to describe the 0 + 2 (7.68 MeV) state of 12 C. The relationship to processes leading to alpha particle channels is discussed. The cross section for 12 C+ 12 C→ 12 C(3 - )+ 12 C(g.s.) is also calculated and possible correlations with inelastic scattering to the 0 + 2 and 2 + states of 12 C are discussed. The results for both 0 + 2 and 3 - inelastic scattering are in reasonable agreement with experiment

Enfermedad de Niemann Pick tipo-A. Presentación de 12 casos

Directory of Open Access Journals (Sweden)

Jorge Zarco-Román

2017-05-01

Full Text Available INTRODUCCIÓN: la enfermedad de Niemann Pick tipo A es una enfermedad hereditaria de depósito lisosomal, debida a un déficit de la enzima esfingomielinasa ácida, lo que da lugar a la acumulación de esfingomielina en las células del sistema reticuloendotelial y nervioso central. OBJETIVO: se describe el curso de la enfermedad de Niemann Pick tipo A en 12 pacientes: tres niños y nueve niñas, con edades entre 3 a 33 meses. MATERIAL Y MÉTODOS: estudio retrospectivo efectuado con base en la información de los expedientes de 12 pacientes, evaluados mediante un examen físico completo, oftalmológico, análisis de laboratorio, ultrasonido de abdomen, tomografía axial computarizada o resonancia magnética nuclear cerebral, radiografías de tórax, ecocardiograma, electroencefalograma, potenciales evocados auditivos y visuales, serie esofagogastroduodenal y serie ósea. Se obtuvo información sobre enfermedades intercurrentes y causas de muerte. RESULTADOS: la sintomatología comenzó en promedio a los 5.9 meses (2 a 16 meses y el diagnóstico definitivo se realizó a la edad de los 15.6 meses (3 a 33 meses a través del cuadro clínico sugestivo, con presencia de células espumosas en el aspirado de médula ósea 12/12 (100% y deficiencia de la enzima esfingomielinasa ácida en 12/12 pacientes (100%; la biopsia hepática fue sugestiva de enfermedad por atesoramiento en 5/12 (41.6%. Las manifestaciones clínicas por orden de frecuencia fueron: hepatoesplenomegalia y afección neurológica en 12/12 (100%, alteración pulmonar 11/12 (91.6%, hematológica 9/12 (80%, oftalmológica con mancha rojo cereza 9/12 (75%, ósea 6/12 (50%, y cardiaca 4/12 (33.3%. Únicamente hubo antecedente de consanguinidad en 4 familias (33.3%. CONCLUSIONES: el curso clínico de la enfermedad de Niemann Pick tipo A es muy similar entre los pacientes afectados, el primer dato clínico detectado es la hepatoesplenomegalia. Los pacientes están asintomáticos los primeros

When Deriving the Spatial QRS-T Angle from the 12-lead ECG, which Transform is More Frank: Regression or Inverse Dower?

Science.gov (United States)

Schlegel, Todd T.; Cortez, Daniel

2010-01-01

Our primary objective was to ascertain which commonly used 12-to-Frank-lead transformation yields spatial QRS-T angle values closest to those obtained from simultaneously collected true Frank-lead recordings. Simultaneous 12-lead and Frank XYZ-lead recordings were analyzed for 100 post-myocardial infarction patients and 50 controls. Relative agreement, with true Frank-lead results, of 12-to-Frank-lead transformed results for the spatial QRS-T angle using Kors regression versus inverse Dower was assessed via ANOVA, Lin s concordance and Bland-Altman plots. Spatial QRS-T angles from the true Frank leads were not significantly different than those derived from the Kors regression-related transformation but were significantly smaller than those derived from the inverse Dower-related transformation (P less than 0.001). Independent of method, spatial mean QRS-T angles were also always significantly larger than spatial maximum (peaks) QRS-T angles. Spatial QRS-T angles are best approximated by regression-related transforms. Spatial mean and spatial peaks QRS-T angles should also not be used interchangeably.

Field-induced interplanar magnetic correlations in the high-temperature superconductor La1.88Sr0.12CuO4

DEFF Research Database (Denmark)

Rømer, A. T.; Jensen, P.; Jacobsen, H.

2015-01-01

We present neutron-scattering studies of the interplanar magnetic correlations in the high-temperature superconductor La1.88Sr0.12CuO4 (Tc=27 K). The correlations are studied both in a magnetic field applied perpendicular to the CuO2 planes, and in zero field under different cooling conditions. We...

10-oxo-12(Z)-octadecenoic acid, a linoleic acid metabolite produced by gut lactic acid bacteria, potently activates PPARγ and stimulates adipogenesis

Energy Technology Data Exchange (ETDEWEB)

Goto, Tsuyoshi, E-mail: tgoto@kais.kyoto-u.ac.jp [Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji 611-0011 (Japan); Research Unit for Physiological Chemistry, The Center for the Promotion of Interdisciplinary Education and Research, Kyoto University (Japan); Kim, Young-Il; Furuzono, Tomoya [Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji 611-0011 (Japan); Takahashi, Nobuyuki [Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji 611-0011 (Japan); Research Unit for Physiological Chemistry, The Center for the Promotion of Interdisciplinary Education and Research, Kyoto University (Japan); Yamakuni, Kanae; Yang, Ha-Eun; Li, Yongjia [Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji 611-0011 (Japan); Ohue, Ryuji [Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji 611-0011 (Japan); Research Unit for Physiological Chemistry, The Center for the Promotion of Interdisciplinary Education and Research, Kyoto University (Japan); Nomura, Wataru [Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji 611-0011 (Japan); Sugawara, Tatsuya [Laboratory of Marine Bioproducts Technology, Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502 (Japan); Yu, Rina [Department of Food Science and Nutrition, University of Ulsan, Ulsan 680-749 (Korea, Republic of); Kitamura, Nahoko [Laboratory of Fermentation Physiology and Applied Microbiology, Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502 (Japan); and others

2015-04-17

Our previous study has shown that gut lactic acid bacteria generate various kinds of fatty acids from polyunsaturated fatty acids such as linoleic acid (LA). In this study, we investigated the effects of LA and LA-derived fatty acids on the activation of peroxisome proliferator-activated receptors (PPARs) which regulate whole-body energy metabolism. None of the fatty acids activated PPARδ, whereas almost all activated PPARα in luciferase assays. Two fatty acids potently activated PPARγ, a master regulator of adipocyte differentiation, with 10-oxo-12(Z)-octadecenoic acid (KetoA) having the most potency. In 3T3-L1 cells, KetoA induced adipocyte differentiation via the activation of PPARγ, and increased adiponectin production and insulin-stimulated glucose uptake. These findings suggest that fatty acids, including KetoA, generated in gut by lactic acid bacteria may be involved in the regulation of host energy metabolism. - Highlights: • Most LA-derived fatty acids from gut lactic acid bacteria potently activated PPARα. • Among tested fatty acids, KetoA and KetoC significantly activated PPARγ. • KetoA induced adipocyte differentiation via the activation of PPARγ. • KetoA enhanced adiponectin production and glucose uptake during adipogenesis.

10-oxo-12(Z)-octadecenoic acid, a linoleic acid metabolite produced by gut lactic acid bacteria, potently activates PPARγ and stimulates adipogenesis

International Nuclear Information System (INIS)

Goto, Tsuyoshi; Kim, Young-Il; Furuzono, Tomoya; Takahashi, Nobuyuki; Yamakuni, Kanae; Yang, Ha-Eun; Li, Yongjia; Ohue, Ryuji; Nomura, Wataru; Sugawara, Tatsuya; Yu, Rina; Kitamura, Nahoko

2015-01-01

Our previous study has shown that gut lactic acid bacteria generate various kinds of fatty acids from polyunsaturated fatty acids such as linoleic acid (LA). In this study, we investigated the effects of LA and LA-derived fatty acids on the activation of peroxisome proliferator-activated receptors (PPARs) which regulate whole-body energy metabolism. None of the fatty acids activated PPARδ, whereas almost all activated PPARα in luciferase assays. Two fatty acids potently activated PPARγ, a master regulator of adipocyte differentiation, with 10-oxo-12(Z)-octadecenoic acid (KetoA) having the most potency. In 3T3-L1 cells, KetoA induced adipocyte differentiation via the activation of PPARγ, and increased adiponectin production and insulin-stimulated glucose uptake. These findings suggest that fatty acids, including KetoA, generated in gut by lactic acid bacteria may be involved in the regulation of host energy metabolism. - Highlights: • Most LA-derived fatty acids from gut lactic acid bacteria potently activated PPARα. • Among tested fatty acids, KetoA and KetoC significantly activated PPARγ. • KetoA induced adipocyte differentiation via the activation of PPARγ. • KetoA enhanced adiponectin production and glucose uptake during adipogenesis

Specific heat of filled skutterudite PrOs4P12

International Nuclear Information System (INIS)

Matsuhira, Kazuyuki; Doi, Yoshihiro; Wakeshima, Makoto; Hinatsu, Yukio; Kihou, Kunihiro; Sekine, Chihiro; Shirotani, Ichimin

2005-01-01

We report the specific heat of filled skutterudite compounds PrOs 4 P 12 and LaOs 4 P 12 down to 1.8K. The specific heat divided by temperature C(T)/T in PrOs 4 P 12 shows a shoulder around 13K. This shoulder is caused by a Schottky anomaly due to a crystalline electric field effect. The electronic specific heat coefficients γ of PrOs 4 P 12 and LaOs 4 P 12 are estimated to be 56.5 and 21.6mJ/K 2 mol, respectively. The value of γ in PrOs 4 P 12 is 2.6 times larger than that in LaOs 4 P 12

Antineurodegenerative effect of phenolic extracts and caffeic acid derivatives in romaine lettuce on neuron-like PC-12 cells.

Science.gov (United States)

Im, Sung-Eun; Yoon, Hyungeun; Nam, Tae-Gyu; Heo, Ho Jin; Lee, Chang Yong; Kim, Dae-Ok

2010-08-01

In recent decades, romaine lettuce has been one of the fastest growing vegetables with respect to its consumption and production. An understanding is needed of the effect of major phenolic phytochemicals from romaine lettuce on biological protection for neuron-like PC-12 cells. Phenolics in fresh romaine lettuce were extracted, and then its total phenolics and total antioxidant capacity were measured spectrophotometrically. Neuroprotective effects of phenolic extract of romaine lettuce and its pure caffeic acid derivatives (caffeic, chicoric, chlorogenic, and isochlorogenic acids) in PC-12 cells were evaluated using two different in vitro methods: lactate dehydrogenase release and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide reduction assays. Total phenolics and total antioxidant capacity of 100 g of fresh romaine lettuce averaged 22.7 mg of gallic acid equivalents and 31.0 mg of vitamin C equivalents, respectively. The phenolic extract of romaine lettuce protected PC-12 cells against oxidative stress caused by H(2)O(2) in a dose-dependent manner. Isochlorogenic acid, one of the phenolics in romaine lettuce, showed stronger neuroprotection than the other three caffeic acid derivatives also found in the lettuce. Although romaine lettuce had lower levels of phenolics and antioxidant capacity compared to other common vegetables, its contribution to total antioxidant capacity and antineurodegenerative effect in human diets would be higher because of higher amounts of its daily per capita consumption compared to other common vegetables.

Improved electrochemical properties of Li{sub 4}Ti{sub 5}O{sub 12}–Li{sub 0.33}La{sub 0.56}TiO{sub 3} composite anodes prepared by a solid-state synthesis

Energy Technology Data Exchange (ETDEWEB)

Zhu, Yan-Rong; Yuan, Jing; Zhu, Min [School of Chemistry and Chemical Engineering, Anhui University of Technology, Maanshan, Anhui 243002 (China); Hao, Guodong [College of Chemistry and Chemical Engineering, Mudanjiang Normal University, Mudanjiang, Heilongjiang 157012 (China); Yi, Ting-Feng, E-mail: tfyihit@163.com [School of Chemistry and Chemical Engineering, Anhui University of Technology, Maanshan, Anhui 243002 (China); Xie, Ying, E-mail: xieying@hlju.edu.cn [Key Laboratory of Functional Inorganic Material Chemistry, Ministry of Education, School of Chemistry and Materials Science, Heilongjiang University, Harbin, Heilongjiang 150080 (China)

2015-10-15

Li{sub 4}Ti{sub 5}O{sub 12}–Li{sub 0.33}La{sub 0.56}TiO{sub 3} composite anodes are successfully prepared by a facile solid state route. The structure, morphology and electrochemical performance of all samples are characterized by X-ray diffraction (XRD), Raman spectroscopy, scanning electron microscope (SEM), cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and charge–discharge tests, respectively. XRD reveals that the little La{sup 3+} ions enter into the lattice, and then make the crystal lattice of Li{sub 4}Ti{sub 5}O{sub 12} expand. SEM shows that all samples are composed of 1–2 μm primary particles with irregular shapes. CV and EIS imply that Li{sub 4}Ti{sub 5}O{sub 12}–Li{sub 0.33}La{sub 0.56}TiO{sub 3} composites have lower polarization, larger lithium-ion diffusion coefficient and smaller charge transfer resistance corresponding to a much higher conductivity than those of Li{sub 4}Ti{sub 5}O{sub 12} corresponding to the extraction of Li{sup +} ions. The improved electrochemical performance of Li{sub 4}Ti{sub 5}O{sub 12}–Li{sub 0.33}La{sub 0.56}TiO{sub 3} composites can be attributed to the enhanced transfer kinetics of both the lithium ions and electrons. Particularly, Li{sub 4}Ti{sub 5}O{sub 12}–Li{sub 0.33}La{sub 0.56}TiO{sub 3} (5 wt.%) composite shows a excellent high-rate capability and cycling stability. Therefore, the present Li{sub 4}Ti{sub 5}O{sub 12}–Li{sub 0.33}La{sub 0.56}TiO{sub 3} (5 wt.%) composite anode is capable of large-scale applications, such as electric vehicles and hybrid electric vehicles, requiring high energy, long life and excellent safety. - Highlights: • The electrochemical property of Li{sub 4}Ti{sub 5}O{sub 12}–Li{sub 0.33}La{sub 0.56}TiO{sub 3} down to 0 V is first reported. • Li{sub 0.33}La{sub 0.56}TiO{sub 3} modifying results in fast lithium insertion/extraction kinetics. • Li{sub 4}Ti{sub 5}O{sub 12}–Li{sub 0.33}La{sub 0.56}TiO{sub 3} (5 wt.%) exhibits a good fast charge

Synthesis and photocatalytic activity of hydrated layered perovskite K2-xLa2Ti3-xNb xO10 (0 ≤ x ≤ 1) and protonated derivatives

International Nuclear Information System (INIS)

Huang Yunfang; Wu Jihuai; Wei Yuelin; Hao Sancun; Huang Miaoliang; Lin Jianming

2007-01-01

A series of photocatalytic intercalated materials K 2-x La 2 Ti 3-x Nb x O 10 (0 ≤ x ≤ 1) and a series of its protonated derivatives H 2-x La 2 Ti 3-x Nb x O 10 were prepared by solid-state reaction and ion-exchange reaction. The photocatalytic activities of samples were evaluated using methanol as electron donor under UV irradiation. All H 2-x La 2 Ti 3-x Nb x O 10 samples possessed approximately twofold higher photocatalytic activity than the corresponding K 2-x La 2 Ti 3-x Nb x O 10 . This difference was most pronounced for the photocatalyst H 1.9 La 2 Ti 2.9 Nb 0.1 O 10 which showed the highest activity: 22 μmol H 2 /catalyst (g) for 5 h, more than three times the activity of K 1.9 La 2 Ti 2.9 Nb 0.1 O 10

XMCD study of the Ruddlesden-Popper phase La1.2Nd0.2Sr1.6Mn2O7

International Nuclear Information System (INIS)

Weigand, F.; Goering, E.; Geissler, J.; Justen, M.; Ruck, K.; Schuetz, G.; Doerr, K.

2001-01-01

X-ray Magnetic Circular Dichroism (XMCD) measurements of the Ruddlesden-Popper Phase La 1.2 Nd 0.2 Sr 1.6 Mn 2 O 7 are reported. The Mn K, La and Nd L 2 , 3 edges have been measured on a powder sample at two different magnetic fields at low temperature. The analysis of the spectra at B = 1T indicates a large orbital moment of the Nd 5d-states and a significant spin-polarization of the La 5d-band. Furthermore at the Mn Κ-edge a XMCD-signal is observed, showing a polarization of the Mn 4p-band. At lower field (0.2T) all XMCD-signals are about two times smaller corresponding to the lower total magnetization. The signal at the Nd L 2 edge vanishes completely at 0.2T. (au)

Radiometría de campo en la enseñanza de la teledetección

OpenAIRE

Epema, Gerrit F.

1992-01-01

Se describe en este artículo la utilización en la enseñanza de la teledetección de un sencillo instrumento para la realización de medidas de reflectividad. El ejemplo que aquí se expone se ha extraído de un curso introductorio sobre aplicaciones de la teledetección que se imparte en la Universidad agrícola de Wageningen, en los Paises Bajos. Use of a simple instrument to measure reflectance in remote sensing education is described. The example is derived from an introductory course i...

Plasma stromal cell-derived factor 1α/CXCL12 level predicts long-term adverse cardiovascular outcomes in patients with coronary artery disease.

Science.gov (United States)

Ghasemzadeh, Nima; Hritani, Abdul Wahab; De Staercke, Christine; Eapen, Danny J; Veledar, Emir; Al Kassem, Hatem; Khayata, Mohamed; Zafari, A Maziar; Sperling, Laurence; Hooper, Craig; Vaccarino, Viola; Mavromatis, Kreton; Quyyumi, Arshed A

2015-01-01

Stromal derived factor-1α/CXCL12 is a chemoattractant responsible for homing of progenitor cells to ischemic tissues. We aimed to investigate the association of plasma CXCL12 with long-term cardiovascular outcomes in patients with coronary artery disease (CAD). 785 patients aged: 63 ± 12 undergoing coronary angiography were independently enrolled into discovery (N = 186) and replication (N = 599) cohorts. Baseline levels of plasma CXCL12 were measured using Quantikine CXCL12 ELISA assay (R&D systems). Patients were followed for cardiovascular death and/or myocardial infarction (MI) for a mean of 2.6 yrs. Cox proportional hazard was used to determine independent predictors of cardiovascular death/MI. The incidence of cardiovascular death/MI was 13% (N = 99). High CXCL12 level based on best discriminatory threshold derived from the ROC analysis predicted risk of cardiovascular death/MI (HR = 4.81, p = 1 × 10(-6)) independent of traditional risk factors in the pooled cohort. Addition of CXCL12 to a baseline model was associated with a significant improvement in c-statistic (AUC: 0.67-0.73, p = 0.03). Addition of CXCL12 was associated with correct risk reclassification of 40% of events and 10.5% of non-events. Similarly for the outcome of cardiovascular death, the addition of the CXCL12 to the baseline model was associated with correct reclassification of 20.7% of events and 9% of non-events. These results were replicated in two independent cohorts. Plasma CXCL12 level is a strong independent predictor of adverse cardiovascular outcomes in patients with CAD and improves risk reclassification. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

La presencia de Negros en la Nordpatagonia. 1779-1837

Directory of Open Access Journals (Sweden)

Dora Noemí Martínez de Gorla

2003-12-01

Full Text Available This paper studies the juridical and social effects created by the individual assimilation of the slave and freeperson in the Rio Negro and the massive entrance of blacks during the war with Brazil, a historic moment when differences were established between African blacks and American blacks. This distinction was modified with the decree of September 12, 1827, when such distinctions were abolished.//Este trabajo estudia los efectos jurídicos y sociales creados por la asimilación individual del esclavo y de la persona libre en el Rio Negro y la entrada masiva de africanos durante la guerra con Brasil, momento histórico en el que las diferencias entre africanos negros y americanos negros fueron establecidas. Esta distinción fue modificada con el decreto 12 de 1827, cuando se abolieron tales diferencias.

La política ambiental pública en el sector extractivismo petrolero ecuatoriano, con énfasis en áreas naturales protegidas. Caso de estudio: bloque 12-15, empresa pública Petroamazonas.

OpenAIRE

Orbe Bastidas, Sofía Alejandra

2016-01-01

La presente investigacio?n aborda la problema?tica en torno a la poli?tica ambiental pu?blica en el sector extractivo petrolero ecuatoriano, con e?nfasis en a?reas naturales protegidas, el intere?s de esta tesis es estudiar como incide la poli?tica ambiental pu?blica en el marco garantista de derechos en la gestio?n ambiental de la empresa pu?blica Petroamazonas en los Bloques 12 y 15, ya que representa el referente de la gestio?n ambiental “responsable” y “sustentable” de la industria hidroc...

Determinación de parámetros cinéticos por la técnica calorimétrica de barrido único. Aplicación a la cristalización no isoterma de la aleación Sb0.12As0.40Se0.48

Directory of Open Access Journals (Sweden)

Jiménez-Garay, R.

2000-08-01

Full Text Available A procedure has been developed for analyzing the evolution with time of the crystallized fraction and for calculating the kinetic parameters at non-isothermal reactions involving formation and growth of nuclei. Considering the assumptions of extended volume and random nucleation, a general expression of the transformed fraction as a function of time has been obtained in isothermal crystallization processes. The crystallization rate deduced has been applied to the non-isothermal processes under the restriction of a nucleation which takes place early in the transformation and the nucleation frequency is zero thereafter. In these conditions, the kinetic parameters have been deduced by using the technique of single-scan. The theoretical method developed has been applied to the crystallization kinetics of the semiconducting Sb0.12As0.40Se0.48 alloy. The kinetic parameters obtained differ by only about 6% of those calculated by multiple-scan techniques, which confirms the reliability and accuracy of the single-scan technique when calculating the mentioned parameters in non-isothermal processes.Se ha desarrollado un procedimiento para analizar la evolución temporal de la fracción cristalizada y calcular los parámetros cinéticos de reacciones no isotermas que implican la formación y crecimiento de núcleos. Considerando las hipótesis de volumen extendido y nucleación al azar, se ha obtenido una expresión general de la fracción transformada como función del tiempo en procesos de cristalización isotermos. La velocidad de cristalización deducida se ha aplicado a procesos no isotermos bajo la restricción de nucleación al principio de la transformación y que se anula posteriormente. En estas condiciones, se han deducido los parámetros cinéticos usando la técnica de barrido único. El método teórico desarrollado se ha aplicado a la cristalización de la aleación semiconductora Sb0.12As0.40Se0.48. Los parámetros cinéticos obtenidos

Color-tunable and luminescence properties of phosphors of Ce{sup 3+} and Tb{sup 3+} co-doped La{sub 5}Si{sub 3}O{sub 12}N for UV w-LEDs

Energy Technology Data Exchange (ETDEWEB)

Deng, Junru; Chen, Jian; Liu, Yangai, E-mail: liuyang@cugb.edu.cn

2016-02-15

A series of Ce{sup 3+}, Tb{sup 3+} and Ce{sup 3+}/Tb{sup 3+} co-doped in La{sub 5}Si{sub 3}O{sub 12}N phosphors were synthesized by conventional high temperature solid state reaction method. With the increase of Tb{sup 3+}, the green emission was realized in (La{sub 0.94−y}Ce{sub 0.06}Tb{sub y}){sub 5}Si{sub 3}O{sub 12}N phosphors on the basis of the efficient energy transfer from Ce{sup 3+} to Tb{sup 3+} with an efficiency (η{sub T}) over 58.72%. The room temperature PL decay curves of the Ce{sup 3+} ions in (La{sub 0.94−y}Ce{sub 0.06}Tb{sub y}){sub 5}Si{sub 3}O{sub 12}N phosphors monitored at 460 nm with an excitation at 365 nm indicated that the energy transfer process between Ce{sup 3+} and Tb{sup 3+} indeed took place. The CIE chromaticity diagrams for (La{sub 0.94−y}Ce{sub 0.06}Tb{sub y}){sub 5}Si{sub 3}O{sub 12}N phosphors were also observed, which shows the color tuned from blue to blue-greenish to green with the increase of Tb{sup 3+} concentration from 0.01 to 0.08. These results demonstrated that Tb{sup 3+} ion with low 4f–4f absorption efficiency in near UV region can play the role of an activator in narrow green-emitting phosphor through efficient energy feeding by allowing 4f–5d absorption of Ce{sup 3+} with high oscillator strength. All the results indicated that the Ce{sup 3+} and Tb{sup 3+} activated La{sub 5}Si{sub 3}O{sub 12}N phosphor may be good candidates for blue-green components in n-UV white LEDs. - Highlights: • A series of Ce{sup 3+}, Tb{sup 3+} and Ce{sup 3+}/Tb{sup 3+} co-doped in La{sub 5}Si{sub 3}O{sub 12}N phosphors were synthesized by high temperature solid state reaction method. • The green emission was realized in (La{sub 0.94−y}Ce{sub 0.06}Tb{sub y})Si{sub 3}O{sub 12}N phosphors on the basis of the highly efficient energy transfer. • The Ce{sup 3+} and Tb{sup 3+} activated La{sub 5}Si{sub 3}O{sub 12}N phosphor may be good candidates for blue-green components in n-UV white LEDs.

Stability of low-temperature Li{sub 7}La{sub 3}Zr{sub 2}O{sub 12} cubic phase: The role of temperature and atmosphere

Energy Technology Data Exchange (ETDEWEB)

Quinzeni, Irene; Capsoni, Doretta; Berbenni, Vittorio; Mustarelli, Piercarlo [Chemistry Department, Physical-Chemistry Section, University of Pavia, Viale Taramelli 16, 27100 Pavia (Italy); Sturini, Michela [Chemistry Department, Analytical Section, University of Pavia, Viale Taramelli 12, 27100 Pavia (Italy); Bini, Marcella, E-mail: bini@unipv.it [Chemistry Department, Physical-Chemistry Section, University of Pavia, Viale Taramelli 16, 27100 Pavia (Italy)

2017-01-01

Rechargeable all solid-state lithium batteries are a promising technology for the next generation of safer batteries. In this context, strict requirements are placed on the electrolytes, among which is emerging the Li{sub 7}La{sub 3}Zr{sub 2}O{sub 12} garnet, chiefly for the relationships among synthesis conditions and phase stability. Here, the structural modifications of the low temperature (LT) Li{sub 7}La{sub 3}Zr{sub 2}O{sub 12} cubic form were investigated by using in situ X-Rays diffraction analysis. In particular, we studied the role of both temperature and atmosphere (air or argon) on phase stabilization. In argon flow, the LT phase is stable under 750 °C, and it transforms into the tetragonal one at lower temperature. In air, it partially decomposes to La{sub 2}Zr{sub 2}O{sub 7} due to Li loss above 250 °C. ICP-OES analysis confirmed that garnet stoichiometry was maintained in argon, whereas in air lithium loss occurred. The structural transformations are driven by the CO{sub 2} absorbed in the LT structure that can form Li{sub 2}CO{sub 3} and/or La{sub 2}(CO{sub 3}){sub 3} so causing stoichiometry changes responsible of the structural evolution. - Highlights: • Li{sub 7}La{sub 3}Zr{sub 2}O{sub 12} is a promising electrolyte for rechargeable all solid state batteries. • The stability of low temperature cubic phase of garnet in argon and air was determined. • The garnet stoichiometry was maintained in argon while in air lithium loss occurred. • The influence of CO{sub 2} adsorption on the structural modifications of garnet was proved.

Microwave dielectric properties of La{sub (1-2x/3)}Ba{sub x}(Mg{sub 0.5}Sn{sub 0.5})O{sub 3} ceramics

Energy Technology Data Exchange (ETDEWEB)

Chen, Yih-Chien; Chen, Kuei-Chien; Hsu, Wei-Yu [Department of Electrical Engineering, Lunghwa University of Science and Technology, Gueishan Shiang, Taoyuan County (China)

2010-11-15

This study examined the potential applications of microwave dielectric properties of La{sub (1-2x/3)}Ba{sub x}(Mg{sub 0.5}Sn{sub 0.5})O{sub 3} ceramics in rectenna. The La{sub (1-2x/3)}Ba{sub x}(Mg{sub 0.5}Sn{sub 0.5})O{sub 3} ceramics were prepared by the conventional solid-state method with various sintering temperatures. An apparent density of 6.62 g/cm{sup 3}, a dielectric constant of 20.3, a quality factor of 51,700 GHz, and a temperature coefficient of resonant frequency of -78.2 ppm/K were obtained for La{sub 2.98/3}Ba{sub 0.01}(Mg{sub 0.5}Sn{sub 0.5})O{sub 3} ceramics that were sintered at 1550 C for 4 h. (copyright 2010 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

Influencia de la transformación austenita-martensita en la estabilidad dimensional de un nuevo acero para herramientas aleado con niobio (0,08% y vanadio (0,12%

Directory of Open Access Journals (Sweden)

Conejero Ortega, Gerardo

2014-09-01

Full Text Available Austenite-martensite transformation influence on the dimensional stability of a new experimental tool steel alloyed with niobium (0.08% wt. and vanadium (0.12% wt. has been studied. The dimensional stability of this new steel was compared with the dimensional stability of commercial steel, after and before two thermal treatments, T1 (860 °C and T2 (900 °C. The thermal treatments consisted on heating and cooling, at 1 atmosphere of pressure, in N2 atmosphere furnace, fol lowing by heating in a conventional furnace at 180 °C during 1 hour. Initially, the experimental steel composition and Ac1 and Ac3 transformation temperatures were determined by glow-discharge luminescence (GDL and dilatometric tests, respectively, in order to select the austenization temperatures of T1 and T2 treatments. After hardness measurement, the microstructure of both steels was characterized by X-Ray Diffraction (XRD and optical metallography, before and after of T1 and T2 thermal treatments. Finally, longitudinal and angular dimensional stability analyses were realized for both commercial and experimental steels. After a contrastive hypothesis analysis, the results showed that the longitudinal relative variation of the experimental steel calculated was around 0.2% and the angular relative variation was not significantSe ha estudiado la influencia de la transformación de austenita a martensita en la estabilidad dimensional de un acero experimental para herramientas aleado con niobio (0,08% en peso y vanadio (0,12% en peso. La estabilidad dimensional del acero experimental fue comparada con la de un acero comercial antes y después de ser sometidos, ambos aceros, a dos tratamientos térmicos diferentes. Los tratamientos térmicos consistieron en un calentamiento y mantenimiento durante una hora a temperaturas de 860 °C (T1 y 900 °C (T2 y un enfriamiento final en horno con nitrógeno (N2 a 1 atmósfera de presión. Inicialmente, se determinaron las composiciones del

A mild pulsed electric field condition that improves acid tolerance, growth, and protease activity of Lactobacillus acidophilus LA-K and Lactobacillus delbrueckii subspecies bulgaricus LB-12.

Science.gov (United States)

Najim, N; Aryana, Kayanush J

2013-06-01

Pulsed electric field (PEF) processing involves the application of pulses of voltage for less than 1 s to fluid products placed between 2 electrodes. The effect of mild PEF on beneficial characteristics of probiotic bacteria Lactobacillus acidophilus and Lactobacillus delbrueckii ssp. bulgaricus is not clearly understood. The objective of this study was to determine the influence of mild PEF conditions on acid tolerance, growth, and protease activity of Lb. acidophilus LA-K and Lactobacillus delbrueckii ssp. bulgaricus LB-12. A pilot plant PEF system (OSU-4M; The Ohio State University, Columbus) was used. The PEF treatments were positive square unipolar pulse width of 3 µs, pulse period of 0.5s, electric field strength of 1 kV/cm, delay time of 20 µs, flow rate of 60 mL/min, and 40.5°C PEF treatment temperature. Both Lb. acidophilus LA-K and Lb. bulgaricus LB-12 subjected to mild PEF conditions were acid tolerant until the end of the 120 min of incubation, unlike the Lb. bulgaricus control, which was not acid tolerant after 30 min. The mild PEF-treated Lb. acidophilus LA-K and Lb. bulgaricus LB-12 reached the logarithmic phase of growth an hour earlier than the control. Mild PEF conditions studied significantly improved acid tolerance, exponential growth, and protease activity of both Lb. acidophilus LA-K and Lb. bulgaricus LB-12 compared with the control. The mild PEF conditions studied can be recommended for pretreating cultures to enhance these desirable attributes. Copyright © 2013 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

METODOLOGÍAS EN LA ENSEÑANZA DE LA DERIVADA: URACCAN-NUEVA GUINEA

Directory of Open Access Journals (Sweden)

William Oswaldo Flores López

2013-10-01

Full Text Available Esta investigación describe la metodología que utilizan profesores de la URACCAN -Nueva Guinea, en la enseñanza-aprendizaje de la Derivada a estudiantes de Administración de Empresas, y cómo esta metodología educativa influye en el rendimiento de la asignatura “Matemática Financiera”. Fue un estudio de caso en el que participaron dos profesores de matemática; los datos fueron obtenidos a través de un cuestionario y entrevista abierta; además, una encuesta que se le suministró al alumnado en las que se les solicitó información relacionada a los procesos metodológicos en el aula. El análisis se desarrolló en función de las redes sistémicas y los resultados muestran que existen diferencias significativas a la hora de abordar el contenido, los resultados comparativos favorecen a los estudiantes a quienes se les facilitó  clases en  la enseña de la Derivada con pertinencia al contexto social y en cuanto al profesor que aborda la Derivada desde el enfoque tradicional, se evidencian calificaciones bajas por parte del estudiantado.SummaryThis research describes the methodology that is been used by teachers of URACCAN-Nueva Guinea, in the teaching and learning of the derivatives with students of Business Administration, and how this educational methodology influences the performance of "Financial Mathematics" as a subject. In this case-study two mathematics teachers participated; the data were obtained through a questionnaire and open interviews, as well as a survey that was provided to the students in which they requested information related to the methodological processes in the classroom.  The analysis was developed based on the systemic networks and the results demonstrated significant differences in addressing the content. The comparative results favor students, due to the fact that they were provided with training classes related to the derivative with pertinence to the social context; and as for the teacher who teaches

A recurrent human papillomavirus integration site at chromosome region 12q14-q15 in SW756 and SK-v cell lines derived from genital tumors

International Nuclear Information System (INIS)

Sastre-Garau, X.; Couturier, J.; Favre, M.; Orth, G.

1995-01-01

The SW756 cell line, derived from an invasive cancer of the uterine cervix, harbours integrated human papillomavirus (HPV) 18 DNA sequences which have been located in chromosome band 12q13. By in situ hybridization experiments with tritiated and digoxigenin-labelled HPV18 probes on R-banded chromosomes, we now localize the integrated viral sequences in 12q14-q15. Interestingly, we have previously localized integrated HPV16 sequences in the same chromosomal region in SK-v cells, derived from a pre-invasive vulvar neoplasia. The chromosomal region 12q14-q15 could thus correspond to a preferential site for the integration of HPV DNA in genital tumors. (authors). 29 refs., 2 figs

La perception d’aliments croquants chez des enfants de 6 à 12 ans : le pain et les pommes

Directory of Open Access Journals (Sweden)

Marie-Odile Monneuse

2003-09-01

Full Text Available Les facteurs organoleptiques des aliments conditionnent la prise alimentaire. L’aspect croquant, une de ces qualités sensorielles qui peut être définie comme la sonorité en bouche, est encore peu étudié. Comment ce critère intervient-il dans le choix de variétés de pain et de pomme, couramment consommées en France, leur appréciation et leur consommation ? Une étude a été menée auprès d’enfants de la région parisienne, 162 pour le pain, 132 pour la pomme, garçons et filles de 6 à 12 ans. Ils ont participé à un test de dégustation (perception et appréciation de deux sortes de pain, baguette et pain de seigle, ou de deux variétés de pomme, Granny Smith et Red Chief, et ils ont répondu à un questionnaire portant sur leur consommation de pains ou de pommes et sur diverses attitudes sensorielles. Les réponses obtenues ont été homogènes, ne variant pas en fonction de l’âge et du sexe. Les enfants se reconnaissent sensibles à la sonorité croquante du pain ou des pommes. Ils disent que l’aspect croquant fait partie des critères d’appréciation des pains ou des pommes, au même titre que d’autres critères, la couleur, la forme, la prise en main, le goût et l’odeur mais ils ne le situent pas tout à fait au même rang, ce qui témoigne de la particularité sensorielle de chacun de ces aliments. L’aspect croquant pourrait participer à l’évaluation de l’appréciation globale d’un morceau de pain, lors de cette dégustation au moins, alors qu’il ne semble pas intervenir pour l’appréciation des pommes dont les saveurs légèrement sucré ou acide sont immédiatement reconnues. Pour le pain, particulièrement la baguette, à la différence de la pomme, semble intervenir un aspect « craquant » correspondant à la sonorité obtenue lorsqu’il est touché à la main ou rompu avant d’être mordu et mastiqué.Among the organoleptic factors involved in food intake, "crunchiness" is a sensory

Derivation of transplantable 7,12-dimethylbenz[a]anthracene-induced chicken fibrosarcoma lines: differences in metastasizing properties and organ specificity

International Nuclear Information System (INIS)

Galton, J.E.; Xue, B.; Hochwald, G.M.; Thorbecke, G.J.

1982-01-01

Transplantable 7,12-dimethylbenz[a]anthracene-induced SC chicken fibrosarcoma (CHCT-NYU) lines were studied for their ability to grow in internal organs after iv injection (artificial metastases) into 1- to 3-week-old chickens. Some tumor lines were recently derived, whereas others were studied after many serial subcutaneous transplantations. Artificial metastases were seen in the stomach, pancreas, lungs, heart, and muscle, and occasionally in the kidneys and liver. Agammaglobulinemic recipients showed more extensive organ involvement than normal recipients of the same age. Whole-body ν-irradiation enhanced the incidence of artificial metastases, particularly in lungs. Antibody from the serum of a primary tumor-bearing host reduced the growth of the corresponding tumor in many organs. The metastatic pattern of line CHCT-NYU4 was a relatively stable property. However, intravenous transplantation of tumor cells from line CHCT-NYU4 taken from the liver, lungs, and pancreas of a single recipient established sublines with changes in organ specificity. After a few such serial transplants of liver-derived tumor, a line was derived that grew virtually in the liver alone. A subline with preference for growth in lungs was also obtained, but its ability to grow in the pancreas persisted. A pancreas-derived tumor line also grew in the liver and lungs. Subcutaneous transplants of tissue fragments of the lung-derived tumor line caused the appearance of spontaneous metastases in lungs. The incidence of spontaneous metastases with the lung-derived line was much greater than that with the liver-derived line or with the original CHCT-NYU4 line

Equazioni a derivate parziali metodi, modelli e applicazioni

CERN Document Server

Salsa, Sandro

2016-01-01

Il testo costituisce una introduzione alla teoria delle equazioni a derivate parziali, strutturata in modo da abituare il lettore ad una sinergia tra modellistica e aspetti teorici. La prima parte riguarda le più note equazioni della fisica-matematica, idealmente raggruppate nelle tre macro-aree diffusione, propagazione e trasporto, onde e vibrazioni. Nella seconda parte si presenta la formulazione variazionale dei principali problemi iniziali e/o al bordo e la loro analisi con i metodi dell'Analisi Funzionale negli spazi di Hilbert.

El recurso previo de inconstitucionalidad según la Ley Orgánica 12/2015: un regreso esperado, una reforma insuficiente // Prior appeal of unconstitutionality according to the Organic Law 12/2015: an expected return, an insufficient amendment

Directory of Open Access Journals (Sweden)

Miguel Ángel Alegre Martínez

2016-12-01

Full Text Available Resumen Este trabajo gira en torno a la Ley Orgánica 12/2015 de 22 de septiembre, que recupera la figura del recurso previo de inconstitucionalidad para los Estatutos de Autonomía y sus reformas. Dicha Ley encuentra sus antecedentes más cercanos en las dos iniciativas parlamentarias presentadas en 2014 por los grupos popular y socialista (que finalmente pactarían su contenido y su precedente más remoto en la anterior regulación del recurso previo por la Ley Orgánica 2/1979 de 3 de octubre, con la que también guarda gran similitud, fundamentalmente en cuanto a legitimación, momento de interponer el recurso, o tramitación del mismo. La comparación entre estas cuatro versiones del recurso previo se lleva a cabo primeramente desde una óptica más descriptiva, dejando paso después a un enfoque más crítico sobre el contenido de la LO 12/2015 y algunos de los problemas que plantea, tanto por el contenido de la reforma que reintroduce el recurso previo (legitimación, plazo para dictar sentencia, coexistencia con el control sucesivo, como por todo lo que en ella se echa de menos (extensión del recurso previo a las leyes orgánicas y otras normas. Las reformas estatutarias emprendidas en España a partir de 2006 reabrieron el debate sobre el recurso previo (que hasta su supresión en 1985 era posible para los Estatutos de Autonomía y las demás Leyes Orgánicas y la necesidad de su recuperación. La LO 12/2015 cubre solo parcialmente las expectativas, puesto que introduce un recurso previo reducido y escasamente renovado, limitando su objeto a los Estatutos de Autonomía y sus reformas, y no extendiéndolo a las demás leyes orgánicas, las reformas constitucionales y otras normas, respecto de las cuales presentaría importantes ventajas frente al control sucesivo. Cualquier solución que se adopte para controlar la constitucionalidad de las leyes es mejorable. Una de las vías para fortalecer el modelo español sería la previsión de

La relación, fuente de valor

OpenAIRE

San Genaro Crego, Alicia

2014-01-01

Ahora más que nunca es crucial tener una buena estrategia de comunicación que derive de la estrategia institucional. La emisión de múltiples mensajes en cualquier medio y en diferentes soportes ha generado en la empresa unas necesidades diferentes, necesidades que ha de suplirse partiendo de un denominador común: la identidad de la organización para generar valor

Synthesis of DL-adrenaline (methyl C{sup 14}) (1961); Synthese de la DL-adrenaline (methyle {sup 14}C) (1961)

Energy Technology Data Exchange (ETDEWEB)

Pichat, L; Audinot, M [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1961-07-01

The sodium derivative of 5-3-4 dibenzyl oxyphenyl 2-oxazolidinone reacted with methyl iodide {sup 14}C, in stoichiometric quantity, gives rise to the corresponding N-methyl {sup 14}C derivative. The oxazolidinone ring is opened by concentrated hydrochloric acid and the benzyl groups removed by catalytic hydrogenolysis. Adrenaline methyl {sup 14}C is then purified on Dowex 50 X-12 exchange resin. Overall-yield is 45 per cent based upon methyl iodide {sup 14}C. (author) [French] Le derive sode de la (dibenzyloxy-3-4-phenyl)-5 oxazolidinone-2 traite par l'iodure de methyle {sup 14}C, en proportion stoechiometrique, fournit le derive N-methyle {sup 14}C correspondant. Apres ouverture du cycle oxazolidinone par HCL concentre et debenzylation par hydrogenation catalytique, on purifie l'adrenaline (methyle {sup 14}C) par chromatographie sur resine echangeuse Dowex 50 X-12. Le rendement est de 45 pour cent par rapport a l'iodure de methyle {sup 14}C. (auteurs)

Synthesis of DL-adrenaline (methyl C{sup 14}) (1961); Synthese de la DL-adrenaline (methyle {sup 14}C) (1961)

Energy Technology Data Exchange (ETDEWEB)

Pichat, L.; Audinot, M. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1961-07-01

The sodium derivative of 5-3-4 dibenzyl oxyphenyl 2-oxazolidinone reacted with methyl iodide {sup 14}C, in stoichiometric quantity, gives rise to the corresponding N-methyl {sup 14}C derivative. The oxazolidinone ring is opened by concentrated hydrochloric acid and the benzyl groups removed by catalytic hydrogenolysis. Adrenaline methyl {sup 14}C is then purified on Dowex 50 X-12 exchange resin. Overall-yield is 45 per cent based upon methyl iodide {sup 14}C. (author) [French] Le derive sode de la (dibenzyloxy-3-4-phenyl)-5 oxazolidinone-2 traite par l'iodure de methyle {sup 14}C, en proportion stoechiometrique, fournit le derive N-methyle {sup 14}C correspondant. Apres ouverture du cycle oxazolidinone par HCL concentre et debenzylation par hydrogenation catalytique, on purifie l'adrenaline (methyle {sup 14}C) par chromatographie sur resine echangeuse Dowex 50 X-12. Le rendement est de 45 pour cent par rapport a l'iodure de methyle {sup 14}C. (auteurs)

Análisis de la diversidad genética de una población de caballos Criollo Argentino mediante polimorfismos de nucleótido simple de los genes IL12B y TNF-α

Directory of Open Access Journals (Sweden)

Claudia Corbi Botto

2016-12-01

Full Text Available La caracterización de una población es el primer paso en el camino hacia su conservación y utilización. La raza Criollo Argentino es una de las referentes de la especie equina en Argentina y, por lo tanto, un patrimonio ganadero local que representa un recurso único en cuanto a la identidad y al sistema productivo del país. El objetivo de este trabajo fue analizar una población de caballos Criollo Argentino del norte de Argentina por medio de la caracterización de la variabilidad genética de cuatro marcadores moleculares del tipo single nucleotide polymorphism (SNP localizados en los genes que codifican para las citoquinas IL-12B y TNF-α. Se recolectaron muestras de 50 caballos Criollo Argentino y se extrajo ADN genómico que se utilizó para tipificar mediante PCR-Pirosecuenciación®, tres SNPs en el promotor del gen TNF-α y uno localizado en el exón 5 del gen IL-12B. Se estimaron frecuencias génicas y genotípicas, equilibrio de Hardy-Weinberg y diversidad genética. En IL-12B se detectaron dos alelos, mientras que en TNF-α se observaron 4 haplotipos, entre ellos uno no descripto hasta el momento en equinos. Los resultados muestran que la heterocigosis esperada fue superior en TNF-α (He=0,764 y la población se encuentra en equilibrio para el locus IL-12B (p-valor ≥0,05. Se destaca la importancia del caballo Criollo Argentino como acervo génico para el estudio de características genéticas y enfermedades de la especie equina.

Identification of Protein Targets of 12/15-Lipoxygenase-Derived Lipid Electrophiles in Mouse Peritoneal Macrophages Using Omega-Alkynyl Fatty Acid.

Science.gov (United States)

Isobe, Yosuke; Kawashima, Yusuke; Ishihara, Tomoaki; Watanabe, Kenji; Ohara, Osamu; Arita, Makoto

2018-04-20

The 12/15-lipoxygenase (12/15-LOX) enzyme introduces peroxyl groups, in a position-specific manner, into polyunsaturated fatty acids to form various kinds of bioactive lipid metabolites, including lipid-derived electrophiles (LDE). The resident peritoneal macrophage is the site of highest 12/15-LOX expression in the mouse. However, the role of the enzyme in the regulation of resident macrophages is not fully understood. Here, we describe a chemoproteomic method to identify the targets of enzymatically generated LDE. By treating mouse peritoneal macrophages with omega-alkynyl arachidonic acid (aAA), we identified a series of proteins adducted by LDE generated through a 12/15-LOX catalyzed reaction. Pathway analysis revealed a dramatic enrichment of proteins involved in energy metabolism and found that glycolytic flux and mitochondrial respiration were significantly affected by the expression of 12/15-LOX. Our findings thus highlight the utility of chemoproteomics using aAA for identifying intracellular targets of enzymatically generated LDE.

La danza y su influencia en la percepción de plenitud y bienestar psicoemocional.

OpenAIRE

Rengifo Rodríguez, Lorelcris; Carrero Planes, Virginia

2016-01-01

Introducción: Desde los resultados obtenidos en diversas investigaciones que han identificado la influencia del trabajo corporal sobre la inteligencia emocional y otras variables psicológicas, se derivó el interés por descubrir los efectos o beneficios de la danza sobre las habilidades emocionales u otros procesos psicosociales asociados al bienestar y plenitud. El trabajo que se presenta tiene como objetivo explorar la vivencia de personas que practican danza, de manera profes...

Incorporación de la fase Zn7Sb2O12 previamente sintetizada en varistores cerámicos basados en ZnO

Directory of Open Access Journals (Sweden)

Caballero, A. C.

2002-02-01

Full Text Available During the sintering process of ZnO-Bi2O3-Sb2O3 based varistors, different reactions take place. The formation of the Zn7Sb2O12 spinel phase occurs between 900 and 1100ºC depending on the composition of the material. The spinel phase acts as ZnO grain growth inhibitor and its distribution on the whole material as a secondary phase in the matrix of ZnO grains determines the kinetics of grain growth. However, it is difficult to control the nucleation and growth of this phase, and this concerns on the final grain size and consequently on the characteristics of the varistor device. The present study has focused on the incorporation of the previously synthesized spinel phase. Scanning Electronic Microscopy analysis of sintered samples reveals a better control of microstructure in those materials with the synthesized spinel phase. The electrical behaviour of these materials agrees with the microstructural features and a greater reproducibility is observed.Una de las reacciones que tiene lugar durante la sinterización de varistores cerámicos basados en el sistema ZnO-Bi2O3-Sb2O3 es la formación de la fase Zn7Sb2O12, de estructura tipo espinela, que ocurre en el intervalo de temperaturas comprendido entre 900 y 1100ºC, dependiendo de la composición específica del material. Esta fase es la responsable del control del crecimiento de grano y su distribución en el seno del material como una segunda fase dispersa en la matriz mayoritaria de granos de ZnO determinará la cinética del crecimiento de los granos. Sin embargo, el proceso de nucleación y crecimiento de esta fase resulta difícil de controlar cuantitativamente, aspecto que se refleja en las características finales del dispositivo varistor obtenido. En el presente trabajo se analiza el efecto de la incorporación de la fase espinela previamente sintetizada a partir de los óxidos de zinc y antimonio. El análisis mediante Microscopía Electrónica de Barrido (MEB de la microestructura de

A study of the complexation of [99mTcO2+] by 2,4-dioxo-1,5,8,12-tetraazacyclotetradecane, 2-oxo-1,5,8,12-tetraazacyclotetradecane and their methylated derivatives in position 3

International Nuclear Information System (INIS)

Riche, F.; Vidal, M.; Pasqualini, R.; Duatti, A.

1992-01-01

The kinetics of complexation of TcO 2 + by 2,4-dioxo-1,5,8,12-tetraazacyclotetradecane, 2-oxo-1,5,8,12-tetraazacyclotetradecane and their methylated derivatives were studied by reducing 99m TcO 4 - with stannous tartrate. The charges of the complexes obtained were studied by electrophoresis; equilibration studies of the complexes with cyclam and a comparative study of the complexation kinetics have served to demonstrate the remarkable kinetic stability of [1,4,8,11-tetraazacyclotetradecane-TcO 2 + ] and [2-oxo-1,5,8,12-tetraazacyclotetradecane-TcO 2 + ]. (author)

Repercusión de la respiración bucal en el sistema estomatognático en niños de 9 a 12 años

Directory of Open Access Journals (Sweden)

Zoila Rosa Podadera Valdés

2013-08-01

Full Text Available Introducción: el acto respiratorio es de gran importancia para estimular y mantener un balance del sistema estomatognático. Objetivo: evaluar la repercusión de la respiración bucal en el sistema estomatognático en niños de 9 a 12 años de edad pertenecientes a la Clínica Estomatológica Docente "Ormani Arenado" de Pinar del Río en el año 2012. Material y método: estudio descriptivo transversal. Universo: todos los niños de 9 a 12 años de edad. Muestra: 197 niños seleccionados mediante un muestreo aleatorio simple. Variables: edad, tipo de respiración, tipo de maloclusión, anomalía de la oclusión, profundidad palatina y tipo facial. Se utilizaron medidas de resumen para variables cualitativas (frecuencia absoluta y porcentajes y medidas de tendencia central (media y desviación estándar para las variables cuantitativas. Para determinar la influencia del tipo de respiración en el tipo de maloclusión y el tipo facial se empleó la prueba Chi-cuadrado y la prueba T de Student en el caso de las variables resalte y profundidad palatina. Resultados: el 27,4% de los pacientes cumplieron la condición de respiradores bucales, con mayor representación del grupo de 10 años de edad (35,2%. En este grupo se diagnosticó una causa determinada en el 61,1%; el 98,1% presentó maloclusión, con predominio de la Clase II; la anomalía de la oclusión más frecuente fue el resalte aumentado y hubo un ligero predominio del tipo dolicofacial. Conclusiones: se concluye que existe una fuerte asociación entre el tipo de respiración y el tipo de maloclusión y el tipo facial.

Composicion corporal y prevalencia estandarizada de desnutricion en niños de 6 a 12 años de edad, La Costa, Argentina

Directory of Open Access Journals (Sweden)

Bolzán Andrés

2003-01-01

Full Text Available OBJETIVOS: evaluar la composición corporal y la prevalencia estandarizada de desnutrición en niños de seis a 12 años de edad de La Costa, Argentina. MÉTODOS: se midieron la estatura, perímetro braquial y el pliegue cutáneo tricipital, calculando los siguientes indicadores: circunferencia muscular braquial, área muscular braquial, área grasa braquial (AGB, índice área muscular braquial/estatura (AMBE, índice energía/proteína (EP e índice grasa/músculo braquiales. Se calculó la prevalencia estandarizada de desnutrición (PE. Se consideraron además tres indicadores sociales. El análisis estadístico incluyó ANOVA multifactorial, correlación de Pearson y de Spearman. RESULTADOS: existió dimorfismo sexual sólo para el AGB. A mayor tamaño de la familia los indicadores antropométricos fueron menores. La PE mostró diferencias con el estándar. El tejido muscular resultó más desviado que el adiposo, aunque el índice AMBT se mantuvo dentro de la normalidad. CONCLUSIONS: El tamaño de la familia modificó el crecimiento global de la población viéndose más afectados los indicadores que incluyen tejido adiposo. Las PE reflejaron mayor sesgo de los indicadores de reserva proteica: AM, PMB que los de reserva energética: PCT, AG.

Egr-1 activation by cancer-derived extracellular vesicles promotes endothelial cell migration via ERK1/2 and JNK signaling pathways.

Directory of Open Access Journals (Sweden)

Yae Jin Yoon

Full Text Available Various mammalian cells, including cancer cells, shed extracellular vesicles (EVs, also known as exosomes and microvesicles, into surrounding tissues. These EVs play roles in tumor growth and metastasis by promoting angiogenesis. However, the detailed mechanism of how cancer-derived EVs elicit endothelial cell activation remains unknown. Here, we provide evidence that early growth response-1 (Egr-1 activation in endothelial cells is involved in the angiogenic activity of colorectal cancer cell-derived EVs. Both RNA interference-mediated downregulation of Egr-1 and ERK1/2 or JNK inhibitor significantly blocked EV-mediated Egr-1 activation and endothelial cell migration. Furthermore, lipid raft-mediated endocytosis inhibitor effectively blocked endothelial Egr-1 activation and migration induced by cancer-derived EVs. Our results suggest that Egr-1 activation in endothelial cells may be a key mechanism involved in the angiogenic activity of cancer-derived EVs. These findings will improve our understanding regarding the proangiogenic activities of EVs in diverse pathological conditions including cancer, cardiovascular diseases, and neurodegenerative diseases.

Uno de análisis reflejo en la Ley de Relaciones del Trabajo n . 12.984 del 02/06/2014 que castiga la discriminación de los portadores del virus VIH y enfermos de SIDA

Directory of Open Access Journals (Sweden)

Maria Aparecida Alkimin

2016-06-01

Full Text Available Desde su surgimiento, la SIDA se hizo una de las grandes causas de discriminación del trabajador en el ambiente laboral y, sin una tutela específica, pero sólo genérica, intensifica la vulnerabilidad del trabajador portador de esa enfermedad. En Brasil, en el ámbito laboral, no hay norma específica en la tutela jurídica de los portadores de SIDA/VIH, valiéndose de orientaciones emanadas por la Constitución Federal y de la Ley 9.029/95 para la defensa de esos trabajadores. La edición de la Ley 12.984/14, objetiva hacer crimen, cualquier forma de discriminación contra la persona en razón de condición de portador del virus o enfermo de SIDA. En el presente trabajo, se hace un análisis en los reflejos que el crimen de discriminación previsto en esta ley pueda repercutir en la seara del Derecho del Trabajo. Se demuestra que la aplicación es bastante promissora, pues el texto comprende tanto la relación de trabajo cuánto relación de empleo, inclusive relación de vínculo estatutario. Buscó la ley proteger el trabajador enmedio ambiente de trabajo, defendiendo el respeto a la dignidad de la persona humana y la consideración a las condiciones físicas del portador del virus y de la enfermedad. Con la presente ley, es indiscutível el avance legislativo brasileño, puniendo con multa y prisión cualquiera ato directo o indirecto de discriminación a las personas en razón de su condición de portador de la enfermedad. Pero aún queda el desafío de la haces visible y realiza su aplicabilidade.

Effects of FeSb6 octahedral deformations on the electronic structure of LaFe4Sb12

KAUST Repository

Pulikkotil, Jiji Thomas Joseph

2011-09-01

First-principles density functional based electronic structure calculations are performed in order to clarify the influence of FeSb6 octahedral deformations on the structural and electronic structure properties of LaFe 4Sb12. Our results show that octahedral tiltings correlate with the band dispersions and, consequently, the band masses. While total energy variation points at an enhanced role of lattice anharmonicity, flat bands emerge from a redistribution of the electronic states. © 2011 Elsevier B.V. All rights reserved.

DE LA DISCIPLINARIEDAD A LA TRANSDISCIPLINARIEDAD. UNA VISIÓN DESDE LA PERSPECTIVA DE LA FORMACIÓN DEL CONTADOR PÚBLICO

Directory of Open Access Journals (Sweden)

Rosa Aura Casal de Altuve

2010-07-01

Full Text Available Los organismos internacionales exigen cambios en cuanto a la formación del contador público. Esta investigación busca presentar los criterios del tránsito disciplinar al transdisciplinar en la formación del contador público. El estudio es de tipo documental y analítico apoyado en discusiones grupales realizadas a los profesores del Departamento de Contabilidad y Finanzas de la Universidad de Los Andes – Venezuela. Como técnica interpretativa se utilizó la hermenéutica y se derivó que el contador público debido a su formación tan disciplinar, ha tenido como efecto una excesiva fragmentación y reducción de los problemas contables, pero por otra parte, no se habla de una formación sólida del contador público sin un estudio profundo de la disciplina contable. Por su parte, la formación del contador público desde la transdisciplinariedad, implica una concepción holística y amplia de los problemas contables, pero requiere no sólo de un cambio de planes de estudio, o de estructuras universitarias, sino un cambio del sujeto (estudiante-docente-autoridad y de la forma de ver al mundo.

Perovskites Ba/sub 2/Bsub(1/2)sup(I)Bsub(1/2)sup(III)Usup(VI)O/sub 6/

Energy Technology Data Exchange (ETDEWEB)

Roller, H; Kemmler-Sack, S [Tuebingen Univ. (Germany, F.R.). Inst. fuer Chemie

1978-11-01

Compounds of type Ba/sub 2/Lisub(1/2)Bsub(1/2)sup(III)Usup(VI)O/sub 6/ and Ba/sub 2/Nasub(1/2)Bsub(1/2)sup(III)Usup(VI)O/sub 6/ are formed with Bsup(III) = La, Nd, Sm, Gd, Y, In as red to reddish brown perovskites. They are for Bsup(III) = La, Nd and Sm polymorphic. With Bsup(III) = La both HT-forms crystallize cubic. In the Li series the HT-modifications with Bsup(III) = Nd, Sm are monoclinic (a < c/..sqrt..2 < b) and in the Na series rhombic (c/..sqrt..2 < a < b); the corresponding Gd, Y, and In compounds have the same structure. The transformation HT ..-->.. TT is reversible. The TT modifications crystallize monoclinic (a < b < c/..sqrt..2). Unlike the HT forms an increase of c and a decrease of a and b is observed, the cell volumina rested nearly unchanged. The origin for the transformation are order disorder phenomena.

294 Analyse de la variabilité germinative de la vesce commune ...

African Journals Online (AJOL)

marwen

... la santé publique [1,2] ; notons l'exemple des régions irriguées par les eaux usées au ... La salinité des sols ainsi que de l'eau de l'irrigation dans ces terrains pose un ... L'application des traitements a été faite dès la mise des graines en ...

Eficacia de la aplicación de actividades físico-recreativas, en el desarrollo motriz en los niños de 10-12 años de la Escuela Santa María de los Lojas

OpenAIRE

Hernández Mite, Kelly Deysi

2014-01-01

La carencia de actividades físico recreativas presentadas en los niños de 10 y 12 años de la Escuela Santa María Los Lojas, y su incidencia en el desarrollo físico motor, dio lugar a esta investigación, dirigida a elaborar una propuesta de programa físico recreativo para ser ejecutado dentro de la jornada escolar, que mejorará el uso del tiempo libre como medio del desarrollo motriz, en los niños de esta escuela. Para ellos se aplicó una encuesta a 42 de ellos, de ambos sexos para determinar ...

Magnetic and ultrasonic studies on double layered CMR manganite La1.2Sr1.8Mn2O7

International Nuclear Information System (INIS)

Reddy, Y.S.; Vishnuvardhan Reddy, C.

2014-01-01

Magnetic and ultrasonic studies were done on La 1.2 Sr 1.8 Mn 2 O 7 to understand the correlation between its magnetic and ultrasonic transitions. The sample transforms from paramagnetic-insulator to ferromagnetic-metallic state at T c ≈124 K. The significant hardening in longitudinal sound velocity measurements (below T c ) is attributed to the coupling between ferromagnetic spins and longitudinal acoustic phonons. (author)

Molecular cytogenetic characterization of mosaicism for a small supernumerary marker chromosome derived from chromosome 8 or r(8(::p12→q13.1:: associated with phenotypic abnormalities

Directory of Open Access Journals (Sweden)

Chih-Ping Chen

2016-12-01

Conclusion: Mosaic sSMC(8 derived from r(8(::p12→q13.1:: can present phenotypic abnormalities. Chromosome 8q12 duplication syndrome should be included in differential diagnosis when an sSMC(8 contains 8q12.2 and CHD7.

A new glucosidic phthalide from Helichrysum microphyllum subsp. tyrrhenicum from La Maddalena Island (Sardinia, Italy).

Science.gov (United States)

Venditti, Alessandro; Lattanzi, Claudia; Ornano, Luigi; Maggi, Filippo; Sanna, Cinzia; Ballero, Mauro; Alvino, Antonello; Serafini, Mauro; Bianco, Armandodoriano

2016-01-01

In this study, we reported the analysis of the medium polarity fraction obtained from an accession of Helichrysum microphyllum subsp. tyrrhenicum from La Maddalena Island. Besides several compounds already evidenced in this species and related genera, i.e. micropyrone (1), arzanol (2), helipyrone (3), acetyl-bitalin derivatives (4, 5), gnaphaliol (6), caffeic acid (7), ursolic acid (8), 7-O-β-(D-glucopyranosyl)-5-methoxy-1(3H)-isobenzofuranone (9), gnaphaliol-9-O-β-D-glucopyranoside (11) and gnaphaliol-3-O-β-D-glucopyranoside (12), the presence of a new glycosidic phthalide, 6-O-β-(D-glucopyranosyl)-4-methoxy-1(3H)-benzofuranone (10), was evidenced for the first time, which resulted in a structural isomer of compound (9). The occurrence of this new benzofuranone derivative is an additional evidence of the deep intraspecific variability expressed by this species, which was also stated for the non-volatile components, and may be a distinctive trait of the population growing on La Maddalena Island.

INTENSIDAD DE LA MUSICA: EFECTO SOBRE LA FRECUENCIA CARDIACA Y EL ESFUERZO PERCIBIDO DURANTE LA ACTIVIDAD FISICA

Directory of Open Access Journals (Sweden)

Jorge Marín Hernández

2001-12-01

Full Text Available La música ha sido ampliamente utilizada en la práctica de ejercicios aeróbicos en la industria deportiva. El propósito de este estudio fue comparar el efecto de diferentes intensidades de la música sobre la frecuencia cardiaca (FC y el esfuerzo percibido (EP durante ejercicio estandarizado en un cicloergómetro. 13 hombres y 5 mujeres voluntarios, físicamente activos (edad 20.6 ± 2.2 años realizaron una prueba bajo tres condiciones en diferentes días, asignadas en un diseño contrabalanceado de medidas repetidas: no música (NM, música a 70 dB, (M70 y música a 85 dB (M85. Ellos se ejercitaron por 20 min. con una carga de trabajo constante predeterminada y equivalente al 80% de su FCMax (kp = 1.47 ± 0.4, 90 rev/min. La música utilizada fue del tipo 'Merengue House' en español con un tempo de 131 ± 4.30 bpm, las diferentes intensidades fueron calibradas con un sonómetro. La FC y el EP fueron registrados a los 10 y 20 min. con un monitor de FC Polar y la escala EP-15 de Borg. Prueba FC 10 min. FC 20 min. EP 10 min. EP 20 min. NM 164.78 ± 8.37 172.11 ± 8.54 12.06 ±1.92 13.78 ±2.58 M70 165.11 ±11.16 173.00 ±12.05 12.00 ±2.11 13.56 ±2.89 M85 163.00 ± 7.58 170.17 ± 7.87 11.50 ±1.55 12.94 ±2.07 Tanto para FC como para EP un ANOVA 3 x 2 con medidas repetidas indicó que los promedios a los 20 min. fueron significativamente mayores que a los 10 min. (p<0.05. Las diferencias en FC y EP entre las tres condiciones no fueron significativas (p >0.05. Los resultados indican que los rangos de intensidades de música estudiados M70 y M85 no produjeron un efecto sobre el EP y la FC cuando se realizó ejercicio estandarizado en un cicloergómetro comparado con una condición sin música NM.

Factors affecting antimicrobial activity of MUC7 12-mer, a human salivary mucin-derived peptide

Directory of Open Access Journals (Sweden)

Bobek Libuse A

2007-11-01

Full Text Available Abstract Background MUC7 12-mer (RKSYKCLHKRCR, a cationic antimicrobial peptide derived from the human low-molecular-weight salivary mucin MUC7, possesses potent antimicrobial activity in vitro. In order to evaluate the potential therapeutic application of the MUC7 12-mer, we examined the effects of mono- and divalent cations, EDTA, pH, and temperature on its antimicrobial activity. Methods Minimal Inhibitory Concentrations (MICs were determined using a liquid growth inhibition assay in 96-well microtiter plates. MUC7 12-mer was added at concentrations of 1.56–50 μM. MICs were determined at three endpoints: MIC-0, MIC-1, and MIC-2 (the lowest drug concentration showing 10%, 25% and 50% of growth, respectively. To examine the effect of salts or EDTA, a checkerboard microdilution technique was used. Fractional inhibitory concentration index (FICi was calculated on the basis of MIC-0. The viability of microbial cells treated with MUC7 12-mer in the presence of sodium or potassium was also determined by killing assay or flow cytometry. Results The MICs of MUC7 12-mer against organisms tested ranged from 6.25–50 μM. For C. albicans, antagonism (FICi 4.5 was observed for the combination of MUC7 12-mer and calcium; however, there was synergism (FICi 0.22 between MUC7 12-mer and EDTA, and the synergism was retained in the presence of calcium at its physiological concentration (1–2 mM. No antagonism but additivity or indifference (FICi 0.55–2.5 was observed for the combination of MUC7 12-mer and each K+, Na+, Mg2+, or Zn2+. MUC7 12-mer peptide (at 25 μM also exerted killing activity in the presence of NaCl, (up to 25 mM for C. albicans and up to 150 mM for E. coli, a physiological concentration of sodium in the oral cavity and serum, respectively and retained candidacidal activity in the presence of KCl (up to 40 mM. The peptide exhibited higher inhibitory activity against C. albicans at pH 7, 8, and 9 than at pH 5 and 6, and temperature up to

Impact of Bifidobacterium animalis subsp. lactis BB-12 and, Lactobacillus acidophilus LA-5-containing yoghurt, on fecal bacterial counts of healthy adults.

Science.gov (United States)

Savard, Patricia; Lamarche, Benoît; Paradis, Marie-Eve; Thiboutot, Hélène; Laurin, Émilie; Roy, Denis

2011-09-01

This randomized, placebo-controlled, double blind, parallel dose-response study investigated the impact of 4-week commercial yoghurt consumption supplemented with Bifidobacterium animalis subsp. lactis (BB-12) and Lactobacillus acidophilus (LA-5) on fecal bacterial counts of healthy adults. Fifty-eight volunteers were randomly assigned to three different groups: 1. placebo (no probiotic, no starter and no green tea extract); 2. Yoptimal (10(9)cfu/100g of BB-12 and LA-5 and 40mg of green tea extract) and 3. Yoptimal-10 (10(10)cfu/100g of BB-12, 10(9)cfu/100g of LA-5 and 40mg of green tea extract). These yoghurt products also contained Lactobacillus delbrueckii subsp. bulgaricus (10(7)cfu/100g) and Streptococcus thermophilus (10(10)cfu/100g). The quantitative PCR (qPCR) results showed that there were significant increases (P=0.02) in bifidobacteria counts with the Yoptimal treatment as compared to baseline. The fecal numbers of B. animalis subsp. lactis and LA-5 significantly increased in the two probiotic treatments compared to the placebo treatment. Viable counts of fecal lactobacilli were significantly higher (P=0.05) and those of enterococci were significantly lower (P=0.04) after the intervention when compared to placebo. No significant difference was observed between treatments in volunteers' weight, waist girth, blood pressure, fasting plasma triglyceride and HDL-C concentrations, as well as cholesterol/HDL-cholesterol ratio. However, a significant increase in plasma cholesterol levels was observed in the placebo group (P=0.0018) but the levels remained stable in the two probiotic yoghurt groups. These results show that probiotic strains supplemented in the form of yoghurt remain active during gut transit and are associated with an increase in beneficial bacteria and a reduction in potentially pathogenic bacteria. This trial was registered at clinicaltrials.gov as NCT00730626. Copyright © 2011 Elsevier B.V. All rights reserved.

U12, a UDCA derivative, acts as an anti-hepatoma drug lead and inhibits the mTOR/S6K1 and cyclin/CDK complex pathways.

Directory of Open Access Journals (Sweden)

Yang Xu

Full Text Available U12, one of 20 derivatives synthesized from ursodeoxycholic acid (UDCA, has been found to have anticancer effects in liver cancer cell lines (SMMC-7721 and HepG2 and to protect normal liver cells from deoxycholic acid (DCA damage (QSG-7701. Its anticancer mechanism was investigated using computer-aided network pharmacology and comparative proteomics. Results showed that its anti-malignancy activities were activated by mTOR/S6K1, cyclinD1/CDK2/4 and caspase-dependent apoptotic signaling pathways in hepatocellular carcinoma cells (HCC. The action of U12 may be similar to that of rapamycin. Animal testing confirmed that U12 exerted better anti-tumor activity than UDCA and had less severe side effects than fluorouracil (5-Fu. These observations indicate that U12 differs from UDCA and other derivatives and may be a suitable lead for the development of compounds useful in the treatment of HCC.

Detection by radio-auto-histography of the β-indolylacetic acid and its metabolic derivatives. Test of application to the search for their histological and cytological location; Detection, par radioautohistographie, de l'acide β-indolylacetique et de ses derives metaboliques. Essai d'application a la recherche de leur localisation histologique et cytologique

Energy Technology Data Exchange (ETDEWEB)

Figier, Jacques

1961-02-04

After having given an overview of research works in biophysics and biochemistry related to the study of the auxinic action within a cell, this research thesis reports the use of radio-auto-histography to detect the βindolylacetic acid within tissues and within a cell. The author reports experiments performed by using this acid either in its normal status, or marked either with carbon 14 or with tritium. Growth tests have been performed by using different plants. The author also presents insolubilization techniques which have been applied to the acid for this study. In vivo tests have been performed with the radioactive acid and other precipitation compounds (lead acetate, mercury nitrate). The acid detection technique is presented, and results are discussed [French] Dans le but de detecter, par radioautohistographie, l'acide β-indolylacetique marque au tritium et ses derives metaboliques, nous avons mis au point des techniques nouvelles d'insolubilisation de l'A.I.A. L'acide picrique et l'acetate de plomb donnant avec l'auxine un precipite insoluble dans les liquides de fixation (Formol neutre-Liquide de Bouin) et d'inclusion, nous avons reussi a conserver dans des epicotyles de pois et de haricot, des racines de feve et de pois, des coleoptiles d'avoine, une importante fraction de l'A.I.A. marque fourni a ces tissus (a des concentrations superieures ou egales a 10 mg/l). Cette detection etant satisfaisante, nous avons essaye de localiser l'A.I.A. et ses derives, avec plus de precision, dans la cellule en particulier. Mais il fallait alors tenir compte de plusieurs causes d'erreur possible: l'effet nocif eventuel du liquide precipitant (acide picrique ou acetate de plomb), - la diffusion d'A.I.A. dans ce liquide, - la cytologie imparfaite et en particulier l'incertitude sur la limite vacuole-cytoplasme. Compte tenu de ces critiques, il nous semble que la radioactivite (due a la presence d'A.I.A. et des produits derives) se localise plus particulierement au

Validación de método analítico para el control de la calidad de vitamina B12 10 000 inyección Validation of analytical method for quality control of B12 Vitamin-10 000 injection

Directory of Open Access Journals (Sweden)

Martha Botet García

2009-12-01

Full Text Available Se validó el método analítico reportado en la Farmacopea de los Estados Unidos, para el control de la calidad de vitamina B12 10 000 U (cianocobalamina inyectable, por espectrofotometría ultravioleta, por ser este un método más sencillo, económico y que permite controlar la calidad del producto terminado. La curva de calibración se realizó en el intervalo de 60 al 140 %, donde fue lineal con un coeficiente de correlación igual a 0,9999; la prueba estadística para el intercepto y la pendiente se consideró no significativa. Se obtuvo un recobrado del 99,97 % en el intervalo de concentraciones estudiado, y las pruebas de Cochran (G y Student (t resultaron no significativas. El coeficiente de variación en el estudio de la repetibilidad fue igual a 0,59 % para las 6 réplicas ensayadas, mientras que en los análisis de la precisión intermedia las pruebas de Fischer y Student no significativas. El método analítico resultó lineal, preciso, específico y exacto en el intervalo de concentraciones estudiadas.Analytical method reported by USA Pharmacopeia was validated for quality control of injectable B12 Vitamin (10 000 U by UV spectrophotometry because this is a simpler and low-cost method allowing quality control of finished product. Calibration curve was graphed at 60 to 140 % interval, where it was linear with a correlation coefficient similar to 0, 9999; statistical test for interception and slope was considered non-significant. There was a recovery of 99.7 % in study concentrations interval where the Cochran (G and Student(t test were not significant too. Variation coefficient in repetition study was similar to 0.59 % for the 6 assayed replies, whereas in intermediate precision analysis, the Fisher and Student tests were not significant. Analytical method was linear, precise, specific and exact in study concentrations interval.

Impacto de la resistencia a la meticilina sobre la mortalidad y vigilancia de la sensibilidad a la vancomicina en bacteriemias causadas por Staphylococcus aureus Impact of methicillin resistance on mortality and surveillance of vancomycin susceptibility in bacteremias caused by Staphylococcus aureus

Directory of Open Access Journals (Sweden)

F. Traverso

2010-12-01

Full Text Available Staphylococcus aureus es uno de los principales patógenos nosocomiales y produce una alta morbimortalidad en numerosos hospitales del mundo. Además, la incidencia de bacteriemias por este microorganismo ha aumentado significativamente en las últimas décadas. Los objetivos del presente trabajo fueron identificar los factores de riesgo que favorecen la aparición de resistencia a la meticilina en aislamientos de S. aureus y los factores que afectan la mortalidad por bacteriemias asociadas a este patógeno, así como evaluar la sensibilidad a la vancomicina de las cepas resistentes a la meticilina. Se estudiaron 39 aislamientos de S. aureus provenientes de hemocultivos de pacientes internados con bacteriemia en la Nueva Clínica Chacabuco de Tandil (Pcia. de Buenos Aires, Argentina en el período 01/2006-12/2008. La mortalidad global fue del 51,3% y estuvo significativamente asociada con la resistencia a la meticilina (OR: 4,20; IC95%: 1,08-16,32; p: 0,05; aunque dicho factor no fue un predictor independiente de mortalidad. La cirugía previa (OR: 17,23; IC95%: 1,80-164,60 y la estancia previa en la unidad de cuidados intensivos (OR: 21,12; IC95%: 2,33-191,30 fueron predictores independientes de la resistencia a la meticilina y la asistencia respiratoria mecánica (OR: 15,99; IC: 3,24-78,86 fue un predictor independiente de la mortalidad. No se detectaron cepas con sensibilidad disminuida a la vancomicina. Todos los aislamientos estudiados fueron sensibles in vitro a la vancomicina, con una CIM50 y una CIM90 de 0,5 μg/ml.Staphylococcus aureus is a major nosocomial pathogen that causes severe morbidity and mortality in many hospitals worldwide. Besides, the incidence of S. aureus bacteremia has significantly increased over the past decades. The aims of this study were to detect the risk factors for methicillin resistance and mortality and to evaluate vancomycin susceptibility in methicillin-resistant isolates. Thus, 39 S. aureus isolates from

Sobre la igualdad entre hombres y mujeres en la Unión Europea : la resolución del Parlamento Europeo, de 8 de marzo de 2011

OpenAIRE

Rodríguez García, Margarita

2011-01-01

I. ANTECEDENTES. II. LA IGUALDAD EN MATERIA LABORAL. 1. El reforzamiento del papel de la mujer en el mercado de trabajo. 1.1. La crisis y las tasas de desempleo. 1.2. La lucha contra la brecha salarial. 2. El fortalecimiento de la presencia de la mujer en puestos de responsabilidad. 3. La eliminación de los estereotipos. III. LA LUCHA FRENTE A LA VIOLENCIA CONTRA LAS MUJERES. IV. LAS POSIBLES SOLUCIONES QUE APORTA EL PARLAMENTO EUROPEO. V. BIBLIOGRAFÍA. Se aborda el exame...

Microstructure evolution and large magnetocaloric effect of La0.8Ce0.2(Fe0.95Co0.05)11.8Si1.2 alloy prepared by strip-casting and annealing

Science.gov (United States)

Zhong, X. C.; Feng, X. L.; Huang, J. H.; Zhang, H.; Huang, Y. L.; Liu, Z. W.; Jiao, D. L.

2018-04-01

The microstructure and magnetocaloric effect of the La0.8Ce0.2(Fe0.95Co0.05)11.8Si1.2 strip-cast flakes annealed between 1273K and 1423K for different time have been investigated. For the flakes annealed for 2h from 1273K to 1423K, the shape and distribution of α-Fe, La-rich and NaZn13-type 1:13 phases are quite sensitive to the annealing temperature. Especially, at a high annealing temperature of 1423K, the 1:13 phase began to decompose into macroscopic α-Fe conglomerations and La-rich dendrites. With the increase of annealing time from 0 to 12h at 1323K, the amount of 1:13 phase increased significantly and reached ˜93.50 wt.% at 12h. However, an overlong annealing time also led to 1:13 phase decomposition and influenced the magnetic performance. For the flakes annealed at 1323K for 12h, large magnetic entropy change value of 18.12Jkg-1K-1 at 5T has been obtained. The present results indicate that strip casting method can potentially be used in mass production of high performance magnetocaloric materials.

Efectividad de la retención post ortodoncia en pacientes de 12-35 años relacionada con 2 tipos de retención fija. Revisión sistemática de la literatura

Directory of Open Access Journals (Sweden)

Marcela Gómez

Full Text Available Resumen Identificar la efectividad de la retención post ortodoncia en pacientes de 12 a 35 años con dos tipos de retención fija, mediante una revisión sistemática de la literatura. Método: Se identificaron las publicaciones mediante búsqueda electrónica en las bases de datos: Cochrane, Pubmed, Science Direct, Isi Web Science, Scielo. Palabras claves: Tooth crowding, Posttreatment, Retainer, Maloclusión, Recurrence, Orthodontic stability, Relapse. Se analizaron por título, resumen y texto completo. Se seleccionaron aquellos que cumplían con los criterios de elegibilidad. Se evaluó la calidad metodológica de los artículos seleccionados, a través de la lista de chequeo Mincir. Se determino el nivel de evidencia y el grado de recomendación a través de la lista SIGN. Resultados: En la búsqueda electrónica inicial, se identificaron 6.632 artículos, de los cuales, posterior a los filtros, se seleccionaron 15 que cumplían con los criterios de inclusión. Se obtuvieron finalmente 4 artículos que cumplieron con los criterios de calidad y de inclusión. Conclusiones: No existe suficiente evidencia científica, en las publicaciones analizadas, que sustente cuál de los dos tipos de retenedores evaluados, presenta mayor efectividad en la retención postortodoncia.

Tumor Imaging in Patients with Advanced Tumors Using a New 99mTc-Radiolabeled Vitamin B12 Derivative

DEFF Research Database (Denmark)

Sah, Bert-Ram; Schibli, Roger; Waibel, Robert

2014-01-01

Targeting cancer cells with vitamin B12 (cobalamin) is hampered by unwanted physiologic tissue uptake mediated by transcobalamin. Adhering to good manufacturing practice, we have developed a new (99m)Tc-cobalamin derivative ((99m)Tc(CO)3-[(4-amido-butyl)-pyridin-2-yl-methyl-amino-acetato] cobalamin......, (99m)Tc-PAMA-cobalamin). The derivative shows no binding to transcobalamin but is recognized by haptocorrin, a protein present in the circulation and notably expressed in many tumor cells. In this prospective study, we investigated cancer-specific uptake of (99m)Tc-PAMA-cobalamin in 10 patients...... with various metastatic tumors. METHODS: Ten patients with biopsy-proven metastatic cancer were included. Dynamic imaging was started immediately after injection of 300-500 MBq of (99m)Tc-PAMA-cobalamin, and whole-body scintigrams were obtained at 10, 30, 60, 120, and 240 min and after 24 h. The relative tumor...

Empleo de la sutura microquirúrgica en la transureteroureterostomía

Directory of Open Access Journals (Sweden)

Rafael Toirac Martínez

1995-06-01

Full Text Available Utilizando 5 perros beagles, se realizó la técnica de la transureteroureterostomía y se aplicaron los procederes de la sutura microquirúrgica; se derivó el uréter izquierdo a través del derecho mediante puntos discontinuos seromusculares, con hilo de sutura de poliamida 10-0 monofilamento y aguja curva espatulada; el objetivo fue demostrar la superioridad de la técnica microquirúrgica sobre el método usualmente empleado. Se exponen los resultados radiológicos y anatomopatológicos obtenidos a los 3, 4 y 6 meses, los que demuestran, radiográficamente, ausencia de lesiones renales y de los sistemas excretores, con buen funcionamiento de la transureteroureterostomía; y anatomopatológicamente, tanto en el estudio macroscópico como en los cortes histológicos de los riñones y del sitio de la anastomosis se comprobó la ausencia de lesiones renales, así como reconstrucción de todos los planos de la pared del uréter. Esta técnica de derivación mediante la microcirugía puede constituir la operación alternativa ideal cuando no sea posible la sutura término-terminal

Geología de la margen activa del Perú entre los 3° y 12° de latitud sur

Directory of Open Access Journals (Sweden)

1990-01-01

Full Text Available GEOLOGIE DE LA MARGE ACTIVE DU PEROU ENTRE 3° ET 12° DE LATITUDE SUD. La structure de la marge de type andin du Pérou est bien connue le long de trois profils sismiques multitraces localisés entre 5° et 12º Sud, au large de Paita (Profil CDP3, de Chimbote (CDP2 et Huacho (CDP1, du Nord vers le Sud. Des données additionnelles existent le long de ces transects il s'agit des levers SeaBEAM et SeaMARC II couvrant de vastes surfaces, de dragages et de carottages. Pendant le Leg. 112 du programme ODP, le Joides Resolution a foré 10 sites essentiellement localisés le long des profils CDP1 (679, 680, 681, 682 et 683 et CDP2 (683, 684 et 685. Les résultats du 'Nazca Plate Project' (1972-1980 ont montré que les roches métamorphiques du socle sud-américain s'étendent au moins jusqu'au bord du plateau continental et que l'accrétion de sédiments existe sur le bas de la pente continentale. Le retraitement postérieur des profils sismiques CDP1, CDP2 et CDP3 et les données bathymétriques SeaBEAM ont montré que la limite entre le socle continental de la marge et le prisme d'accrétion est localisé à la limite entre la pente moyenne et la pente inférieure de la marge. Cette limite marque également un changement dans le régime tectonique de la marge qui passe de l'extension pour le haut de pente à la compression vers le bas de pente. Les profils sismiques CDP1 et CDP2 montrent une discordance majeure de l'Eocène sur le socle identique à celle forée aux puits pétroliers Delphin et Ballena. Cette discordance est attribuée à la phase Incaïque (67 Ma à 57 Ma bien connue à terre. Pendant le Leg. 112, l'Eocène a été foré sur trois sites de la pente moyenne et du bas de pente de la marge. Au site 688, l'Eocène présente des faciès marins de faible profondeur d'eau appartenant au plateau continental et à la pente supérieure comme l'indiquent les foraminifères benthiques. Cet Eocène (57 Ma à 40 Ma est recouvert en discordance

Dense garnet-like Li5La3Nb2O12 solid electrolyte prepared by self-consolidation method

Science.gov (United States)

Zhao, Pengcheng; Xiang, Yu; Xu, Yan; Wen, Yuehua; Zhang, Wenfeng; Zhu, Xiayu; Li, Meng; Zhang, Sontong; Ming, Hai; Jin, Zhaoqing; Cao, Gaoping

2018-06-01

Li5La3Nb2O12 (LLNO) is a typical garnet-like solid electrolyte with solitary cubic structure. However, its ionic conductivity is relatively low due to the low relative density when prepared by cold isostatic pressing method, which usually involves high-pressure machines, poor productivity, tedious pressing operations, and low density. In this paper, self-consolidation method is developed to sinter dense LLNO electrolyte. Although not any pressing operations are employed in the entire process, the relative density of LLNO is promoted up to 95%, which is much higher than the reported values of 45-80%. SEM images reveal that the sample is built by huge particles in size of 80 μm indicating that there are few boundaries in the sample. Moreover, a rich content of Li-Al-O compounds is detected out in the boundary areas, which may act as sintering aids for the sample to consolidate automatically. According to the highest density, the bulk ionic conductivity of LLNO sample reaches up to 1.61 × 10-4 S cm-1 at 30 °C, which is in the same order of magnitude as the value of cubic Li7La3Zr2O12 electrolyte. This work verifies the self-consolidation mechanism for the sintering of ceramic electrolytes and could significantly facilitate the development of LLNO membrane technology.

Design, synthesis and antimalarial activity of novel bis{N-[(pyrrolo[1,2-a]quinoxalin-4-yl)benzyl]-3-aminopropyl}amine derivatives.

Science.gov (United States)

Guillon, Jean; Cohen, Anita; Gueddouda, Nassima Meriem; Das, Rabindra Nath; Moreau, Stéphane; Ronga, Luisa; Savrimoutou, Solène; Basmaciyan, Louise; Monnier, Alix; Monget, Myriam; Rubio, Sandra; Garnerin, Timothée; Azas, Nadine; Mergny, Jean-Louis; Mullié, Catherine; Sonnet, Pascal

2017-12-01

Novel series of bis- and tris-pyrrolo[1,2-a]quinoxaline derivatives 1 were synthesized and tested for in vitro activity upon the intraerythrocytic stage of W2 and 3D7 Plasmodium falciparum strains. Biological results showed good antimalarial activity with IC 50 in the μM range. In attempting to investigate the large broad-spectrum antiprotozoal activities of these new derivatives, their properties toward Leishmania donovani were also investigated and revealed their selective antiplasmodial profile. In parallel, the in vitro cytotoxicity of these molecules was assessed on the human HepG2 cell line. Structure-activity relationships of these new synthetic compounds are discussed here. The bis-pyrrolo[1,2-a]quinoxalines 1n and 1p were identified as the most potent antimalarial candidates with selectivity index (SI) of 40.6 on W2 strain, and 39.25 on 3D7 strain, respectively. As the telomeres of the parasite could constitute an attractive target, we investigated the possibility of targeting Plasmodium telomeres by stabilizing the Plasmodium telomeric G-quadruplexes through a FRET melting assay by our new compounds.

La influencia de la red social en la salud mental de la población anciana The influence of the social network on mental health in the elderly

Directory of Open Access Journals (Sweden)

Carol Lahuerta

2004-04-01

Full Text Available Objetivos: Describir la red social, el apoyo social y la salud mental en la población no institucionalizada de 65 o más años de Barcelona, y analizar la relación entre salud mental, red social y apoyo social según el sexo y el grupo de edad. Métodos: Estudio transversal. La muestra esta formada por personas de 65 o más años entrevistadas en la Encuesta de Salud de Barcelona 2000 (389 varones y 609 mujeres. La salud mental se valoró mediante el General Health Questionnaire-12 (GHQ-12. Se realizó un análisis descriptivo, así como un análisis bivariado y multivariado (regresión logística, para evaluar la relación entre la presencia de trastornos mentales y las variables de red y apoyo social, ajustado por el estado de salud percibido y las discapacidades. Resultados: Según el GHQ-12, el 21,8% de las mujeres y el 9,4% de los varones sufren trastornos mentales. El análisis multivariado en los varones pone de manifiesto que no ver a los amigos regularmente está asociado con sufrir trastornos mentales en el grupo ≥ 75 años (odds ratio [OR] = 5,76; intervalo de confianza [IC] del 95%, 1,77-18,7; el menor apoyo social, según el Perfil de Duke, y la falta de apoyo emocional están relacionados en los 2 grupos de edad analizados (65-74 y ≥ 75 años. En las mujeres de 75 o más años, el no ver a los amigos regularmente también se asocia con la presencia de trastornos mentales, y el menor apoyo social según el Perfil de Duke se asocia en ambos grupos de edad analizados. Conclusiones: Existe una relación entre la red y el apoyo social y la salud mental en la población anciana de Barcelona. Las políticas de integración social podrían tener efectos beneficiosos para la salud mental de esta población.Objectives: To describe social networks, social support and mental health among non-institutionalized individuals aged 65 years or older of Barcelona (Spain, and to analyze the relationship between mental health and social network

Las geociencias en la filatelia

Directory of Open Access Journals (Sweden)

Moreno Murillo Juan Manuel

1993-10-01

Full Text Available

12pt;">La Filatelia ha sido conocida desde antaño como el "pasatiempo de los reyes y el rey de los pasatiempos", manteniendo y aumentando su popularidad, aun luego de cumplir 153 años desde la introducción del sello de correos.

12pt;">La Academia de la Lengua Española define la Filatelia como el Arte o Ciencia que consiste en estudiar y coleccionar sellos de correos o estampillas postales y  materiales afines. Sin embargo, el Correo es anterior a las estampillas pero estas, fueron la causa por la cual el correo se popularizó.

12pt;">La palabra Filatelia está compuesta de dos vocablos griegos: phi/os que significa amante o amigo y, atelia que se deriva de ateles y que significa pegado de antemano, es decir sello.

La función guerrera en la mitología de la Gallaecia antigua. Contribución a la sociología de la cultura castreña

Directory of Open Access Journals (Sweden)

José Carlos BERMEJO BARRERA

2009-12-01

Full Text Available RESUMEN: En este trabajo, partiendo de la descripción dada por Estrabón (III, 3, 7 [155] acerca del culto tributado por los pueblos del Norte de la Península aun dios similar al Ares griego, se deduce la existencia de una deidad céltica de la Segunda Función similar al Mars romano, al Ares griego y a los dioses de la guerra célticos, que aparece representado en los términos derivados de la raíz coso- en la epigrafía latina de la región. Esta divinidad, como las restantes divinidades de la guerra, aparece asociada a un grupo social muy concreto: la aristocracia militar, formada por guerreros profesionales.ABSTRACT: In this work, starting from the description given by Strabo (III, 3, 7 [155] about the homage paid by the North Iberian Peninsula people to a God of War similar to the Greek Ares, a conclusion is reach regarding the existence of a Celtic deity of the Second Function similar to the Roman Mars, the Greek Ares and the Celtic War Gods, that appears symbolized in the terms derived from the root coso- in the Latin inscriptions of the region. This deity —like the remaining martial deities that are similar— appears linked to a very concrete social group: the military aristocracy, formed by professional warriors.

Effect of halogen substitution on the enthalpies of solvation and hydrogen bonding of organic solutes in chlorobenzene and 1,2-dichlorobenzene derived using multi-parameter correlations

Energy Technology Data Exchange (ETDEWEB)

Varfolomeev, Mikhail A.; Rakipov, Ilnaz T.; Khachatrian, Artashes A. [Department of Physical Chemistry, Kazan Federal University, Kremlevskaya 18, Kazan 420008 (Russian Federation); Acree, William E., E-mail: acree@unt.edu [Department of Chemistry, 1155 Union Circle # 305070, University of North Texas, Denton, TX 76203-5017 (United States); Brumfield, Michela [Department of Chemistry, 1155 Union Circle # 305070, University of North Texas, Denton, TX 76203-5017 (United States); Abraham, Michael H. [Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ (United Kingdom)

2015-10-10

Graphical abstract: - Highlights: • Enthalpies of solution measured for 43 solutes dissolved in chlorobenzene. • Enthalpies of solution measured for 72 solutes dissolved in 1,2-dichlorobenzene. • Mathematical expressions derived for predicting enthalpies of solvation of solutes in chlorobenzene. • Mathematical expressions derived for predicting enthalpies of solvation of solutes in 1,2-chlorobenzene. - Abstract: Enthalpies of solution at infinite dilution at 298 K, Δ{sub soln}H{sup A/Solvent}, have been measured by isothermal solution calorimetry for 43 and 72 organic solutes dissolved in chlorobenzene and 1,2-dichlorobenzene, respectively. The measured Δ{sub soln}H{sup A/Solvent} data, along with published Δ{sub soln}H{sup A/Solvent} values taken from the published literature for solutes dissolved in both chlorobenzene solvents, were converted to enthalpies of solvation, Δ{sub solv}H{sup A/Solvent}, using standard thermodynamic equations. Abraham model correlations were developed from the experimental Δ{sub solv}H{sup A/Solvent} data. The best derived correlations describe the experimental gas-to-chlorobenzene and gas-to-1,2-dichlorobenzene enthalpies of solvation to within standard deviations of 1.5 kJ mol{sup −1} and 1.9 kJ mol{sup −1}, respectively. Enthalpies of X−H…π (X – O, N, and C) hydrogen bond formation of proton donor solutes (alcohols, amines, chlorinated hydrocarbons, etc.) with chlorobenzene and 1,2-dichlorobenzene were calculated based on the Abraham solvation equation. Obtained values are in good agreement with the results determined using conventional methods.

Electron addition to alkyl cobalamins, coenzyme B12 and vitamin B12

International Nuclear Information System (INIS)

Rao, D.N.R.; Symons, M.C.R.

1983-01-01

Exposure of dilute solutions of methyl and ethyl cobalamins and coenzyme B 12 in dilute solutions (D 2 O+CD 3 OD) to 60 Co #betta#-rays at 77 K gave a single broad feature in the free-spin region assigned to electron-capture species with the excess electron largely confined to a π* corrin orbital. On warming above 77 K the methyl derivative gave a novel species with spectral features characteristic of an unpaired electron in the Co(dsub(x 2 -y 2 )) orbital. The other two substrates gave spectra due to Cosup(II)Bsub(12r) both on warming and after photolyses with visible light. The acetyl derivative gave an electron-capture species whose e.s.r. spectrum was characteristic of an electron in the Co(dsub(z 2 )) orbital, which on warming above 77 K changed to the normal Cosup(II)Bsub(12r) spectrum. The cyano derivative (vitamin B 12 ) gave electron addition into the Co(dsub(z 2 )) orbital, as evidenced by the large hyperfine coupling to 13 C from 13 CN ligands. On annealing, cyanide ions were lost irreversibly, Bsub(12r) being detected by e.s.r. spectroscopy. In contrast, the dicyano derivative on electron addition at 77 K gave a species containing only one 13 CN ligand. Hence in this case one CN - ligand was lost at 77 K, with no return of the dimethylbenzimidazole ligand. These results are discussed in terms of a new mechanism for electron-addition to alkyl cobalamins. (author)

e-Tesis: la biblioteca digital de tesis doctorales de la Universidad de Córdoba

OpenAIRE

Murillo-Fernández, José Ángel; Guzmán-Pérez, Catalina; Cámara-Aroca, Mercedes

2008-01-01

Comunicación presentada a la 3ª Reunión del Grupo OS/Repositorios: La proyección de los repositorios institucionales. Madrid, 10-12 Diciembre 2008. Se presenta en el trabajo una herramienta diseñada para la gestión integral de las tesis doctorales de la Universidad de Córdoba (UCO). La aplicación “e-Tesis” permite el seguimiento electrónico del proceso desde que el doctorando presenta la tesis, el período de exposición pública, la lectura y la publicación digital; todo ello garantizando...

Synthesis and biological evaluation of new C-12(α/β)-(N-) sulfamoyl-phenylamino-14-deoxy-andrographolide derivatives as potent anti-cancer agents.

Science.gov (United States)

Kandanur, Sai Giridhar Sarma; Nanduri, Srinivas; Golakoti, Nageswara Rao

2017-07-01

Andrographolide, the major diterpenoidal constituent of Andrographis paniculata (Acanthaceae) and its derivatives have been reported to possess plethora of biological properties including potent anti-cancer activity. In this work, synthesis and in-vitro anti-cancer evaluation of new C-12-substituted aryl amino 14-deoxy-andrographolide derivatives (III a-f) are reported. The substitutions include various sulfonamide moieties -SO 2 -NH-R 1 . The new derivatives (III a-e) exhibited improved cytotoxicity (GI 50 , TGI and LC 50 ) compared to andrographolide (I) and the corresponding 3,14,19-O-triacetyl andrographolide (II) when evaluated against 60 NCI cell line panel. Compounds III c and III e are found to be non-toxic to normal human dermal fibroblasts (NHDF) cells compared to reference drug THZ-1. Copyright © 2017 Elsevier Ltd. All rights reserved.

Novedades nomenclaturales en la tribu Stipeae (Poaceae, Pooideae) para la Flora Argentina

OpenAIRE

Ana María Cialdella

2010-01-01

Durante la revisión de los géneros de Stipeae (Poaceae) para la flora argentina y de acuerdo a los últimos estudios filogenéticos en la tribu, se confirmó la necesidad de transferir algunos taxones recientemente descriptos de Stipa a Nassella, Jarava o Pappostipa. En este trabajo se presentan 12 nuevas combinaciones: Jarava ichu var. pungens, Nassella brachyglumis, N. macrotricha, Pappostipa arenicola, P. choconensis, P. colloncurensis, P. frigida var. longifolia, P. jucunda, P. kieslingii, P...

Influencia de las alteraciones estéticas buco-dentales sobre la autoimagen y sociabilización en adolescentes entre 12-17 años

Directory of Open Access Journals (Sweden)

Paola Naranjo

2015-12-01

Full Text Available El impacto que causan las patologías bucales sobre la estética facial ha sido motivo de numerosos estudios, llegando a deducir que la apariencia física es un factor trascendental a la hora de entablar relaciones sociales o simplemente para realizar una autocrítica y que la odontología estaría implicada en brindar soluciones a estos problemas. La presente investigación tuvo como objetivo principal el estudio de la influencia de las alteraciones estéticas buco-dentales sobre la autoimagen y la sociabilización en los adolescentes de edades comprendidas entre 12 y 17 años pertenecientes al Instituto Tecnológico Andrés F. Córdova. Se llevó a cabo un estudio analítico, descriptivo, observacional y transversal en el cual se examinaron clínicamente a los participantes y únicamente se seleccionaron a aquellos que presentaron alteraciones patológicas buco-dentales que afectaran su estética facial, los cuales fueron 161 y posteriormente se pidió a cada uno de ellos contestar una encuesta de 15 ítems donde se valora la presencia de problemas de autocrítica o sociabilización y cuáles son sus acciones, sentimientos, manifestaciones y expectativas acerca de su problema. El estudio evidenció que los jóvenes experimentaron un impacto negativo sobre su imagen personal que influye en el desarrollo de problemas de autopercepción. Por otro lado los participantes fueron menos críticos en la evaluación de su aspecto estético en relación a lo social, ya que no hacían alusión la influencia de la afección estética buco-dental sobre la socialización.

New functionalized mercaptoundecahydrododecaborate derivatives for potential application in boron neutron capture therapy: synthesis, characterization and dynamic visualization in cells.

Science.gov (United States)

Genady, Afaf R; Ioppolo, Joseph A; Azaam, Mohamed M; El-Zaria, Mohamed E

2015-03-26

A series of mercaptoundecahydrododecaborate (B12H11SH(2-), BSH) bearing mono- and dicarboxyalkyl derivatives was prepared, characterized, and their reactivity towards amidation and esterification in DMF was evaluated. Symmetrical alkylation of BSH was achieved by treatment with primary haloalkyl carboxylic acids in aqueous acetonitrile to produce S,S-bis(carboxyalkyl)sulfonium-undecahydro-closo-dodecaborate tetramethylammonium salts. Unsymmetrically substituted sulfonium salts were obtained through a similar treatment of cyanoethylthioether-undecahydro-closo-dodecaborate tetramethylammonium salt with haloalkyl carboxylic acid. Selective removal of the remaining cyanoethyl group upon treatment with tetramethylammonium hydroxide yielded S-carboxyalkyl-thioether-undecahydro-closo-dodecaborate ditetramethylammonium salts. N,N'-dicyclohexylcarbodiimide (DCC) activated amidation of S,S-bis(carboxyalkyl)sulfonium-undecahydro-closo-dodecaborate or S-carboxyalkyl-thioether-undecahydro-closo-dodecaborate tetramethylammonium salts with propargylamine provided the opportunity to install terminal acetylene groups for further conjugation. These compounds acted as powerful building blocks for the synthesis of a broad range of 1,4-disubstituted 1,2,3-triazole products in high yields, utilizing the Cu(I)-mediated click cycloaddition reaction. The synthesis of BSH-lipid with a two-tailed moiety was also achieved, by esterification of S,S-bis(carboxyethyl)sulfoniumundecahydro-closo-dodecaborate(1-) tetramethylammonium salt with 1,2-O-distearoyl-sn-3-glycerol, which may prove useful in the liposomal boron delivery system. The bio-compatibility of the azide-alkyne click reaction was then utilized by performing this reaction in cell culture. The distribution of BSH in HeLa cells could be visualized by treating the cells first with a BSH-alkyne compound and then with Alexa Fluor 488(®) azide dye. The BSH-dye conjugate, which did not wash out, revealed the distribution of boron in the HeLa

Efecto de la aireación y la concentración de cloruro sódico en el desarrollo de la flora microbiológica y en los parámetros fisicoquímicos en la fermentación de Olea europaea L. c.v. Sevillana al estilo negras naturales en la zona de La Yarada-Tacna

Directory of Open Access Journals (Sweden)

Clavijo Koc, C.

2013-06-01

Full Text Available The aerobic fermentation of the table olive variety, Sevillana a black style, was carried out, taking into account the parameters of fermentation of fixed acidity between 1.2 to 1.5% and depended on the chloride concentration in the brine. This concentration was under 6.5% in the 9 treatments assayed, allowing for the lactic bacteria to develop. In the aerobic fermentation there were no differences in the decline of pH in relation to the anaerobic fermentation, which reached values below 3.5. The air effect is of great significance in the purge of the carbon dioxide in the brine. At the same time, the effect of air significantly affects the increase in aerobic yeast. The facultative anaerobic yeasts developed in the treatments with an initial salt level of 12% at the beginning of fermentation. The reduction of sugar concentration into the fruit decreased significantly in the treatment with air. Aerobic fermentation is more rapid than anaerobic fermentation.La fermentación aerobia de aceituna variedad Sevillana estilo negra se desarrolló en los parámetros de acidez fija entre de 1.2 a 1.5%, debido a la concentración de cloruros en la salmuera los cuales se mantuvieron por debajo de 6.5% durante el periodo de fermentación en los 9 tratamientos ensayados lo que permitió el desarrollo de bacterias lácticas. No hubo diferencia en la evolución del pH entre la fermentación con aireación o en condiciones anaeróbicas alcanzándose valores menores a 3.5. La aireación tiene un efecto significativo en la purga del CO2 en la salmuera e incrementó la población de levaduras aerobias; así mismo en los tratamientos con 12% de sal se favoreció el desarrollo de levaduras fermentativas al inicio de la fermentación. La concentración de azúcares reductores en el fruto disminuyó significativamente en los tratamientos con aireación, acelerando el proceso de fermentación con respecto a la fermentación anaerobia.

La Chalupa mission No. 12. Final report

International Nuclear Information System (INIS)

Castro, R.; Davis, P.H.; Kimmel, J.J.; Purcell, T.W.; Rivera, J.A.

1975-03-01

The Islote area on the north coast of Puerto Rico is under consideration as a nuclear power plant site. The Puerto Rico Nuclear Center (PRNC) has been contracted to collect both physical and biological baseline data on the marine environment at this site. The underwater habitat, La Chalupa, was made available for 16 days in May and June 1974. This facility allowed PRNC staff an opportunity to evaluate the ecology of the area from a different perspective, itioned approximately 900 meters offshore in 22 meters of water. Within this area, different habitats were determined, observations were made, and samples were collected. The relative distribution of the dominant benthic flora and fauna was studied. The ecological relationships of several commercially valuable organisms such as conch, lobster, and crabs were investigated. Several physical parameters (sedimentation, sediment transport, and currents) were considered in relation to animal distribution. Most fishes could be observed and their abundance and importance in the area estimated. Data gathered during the mission provides informationa in the form of: identification of populations and major species near the bottom; determination of changes which might occur in the populations as a result of tidal influences or time of day; and determination of a crude idea of productivity in the study area by use of cell counts, chlorophyll measurements, and dark-light bottle studies. Evaluation of La Chalupa tool is presented. Tables are presented of species lists of benthic organisms, fishes, and phytoplankton. (U.S.)

Electronic spectra and DFT calculations of some pyrimido[1,2-a]benzimidazole derivatives

Science.gov (United States)

Elshakre, Mohamed E.; Moustafa, H.; Hassaneen, Huwaida. M. E.; Moussa, Abdelrahim. Z.

2015-06-01

Ground state properties of 2,4-diphenyl-1,4-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine, compound 1, and its derivatives are investigated experimentally and theoretically in Dioxane and DMF. The calculations show that all the studied compounds (1-7) are non-planar, resulting in a significant impact on the electronic and structural properties. The ground state properties of compounds 1-7 at B3LYP/6-311G (d, p) show that compound 5 has the lowest EHOMO, ELUMO, and ΔE indicating highest reactivity. Compound 7 is found to have the highest polarity. The observed UV spectra in Dioxane and DMF of compounds 1-4 show 2 bands, while compounds 5-7 show 4 bands in both solvents. Band maxima (λmax) and intensities of the spectra are found to have solvent dependence reflected as blue and red shifts. The theoretical spectra computed at TD-B3LYP/6-311G (d, p) in gas phase, Dioxane and DMF indicate a good agreement with the observed spectra.

Interrelation of transport properties, defect structure and spin state of Ni3+ in La1.2Sr0.8Ni0.9Fe0.1O4+δ

Science.gov (United States)

Gilev, A. R.; Kiselev, E. A.; Zakharov, D. M.; Cherepanov, V. A.

2017-10-01

The total conductivity, Seebeck coefficient and oxygen non-stoichiometry for La1.2Sr0.8Ni0.9Fe0.1O4+δ have been measured vs temperature and oxygen partial pressure P(O2). The measurements were carried out at 800, 850, 900 and 950 °C within the P(O2) range of 10-5-0.21 atm. La1.2Sr0.8Ni0.9Fe0.1O4+δ was shown to be oxygen deficient in all temperature and P(O2) ranges studied. The calculated values of the partial molar enthalpy of oxygen depend very slightly on oxygen content (δ), indicating that La1.2Sr0.8Ni0.9Fe0.1O4+δ with the oxygen deficiency can be considered an ideal solution. The model of point defect equilibria in La1.2Sr0.8Ni0.9Fe0.1O4+δ has been proposed and fitted to experimental dependencies. Subsequent joint analysis of the defect structure and transport properties revealed that electron holes can coexist in both localized and quasi-delocalized states in the oxide: the former corresponded to high-spin state Ni3+ and the latter - to low-spin state Ni3+. The mobilities of localized electron holes were shown to be significantly lower in comparison to quasi-delocalized ones. The behavior of localized electron holes was explained in terms of a small polaron conduction mechanism; in contrast, quasi-delocalized electron holes were described in terms of a band conduction approach. The small polaron conduction mechanism was shown to be predominant in the Sr- and Fe-co-doped lanthanum nickelate.

La derrota de la agronomía, romper un camino a través del bosque

Directory of Open Access Journals (Sweden)

Torres Enrique

2002-12-01

Full Text Available

12.0pt; font-family: ";Arial";,";sans-serif";;">Quienes tienen la fortuna de abrevar en las fuentes de la evolución saben que todo lo que nos rodea, sean ciudades y culturas, ciencia y tecnología, estructuras sociales, políticas y económicas, fauna y flora, o mitos, ritos, y símbolos, debe su existencia a los cambios y no pocas veces a la desaparición de formas arcaicas. En efecto, la muerte y las extinciones despejan el camino para nuevos e impredecibles desarrollos. Para citar un ejemplo cercano y trillado, la extinción de los dinosaurios hace 60 millones de años permitió la expansión de los mamíferos que condujo a su vez al surgimiento de los euprimates hace 56 millones de años.

12.0pt; font-family: ";Arial";,";sans-serif";;"> 

12.0pt; font-family: ";Arial";,";sans-serif";;">El lenguaje no es ajeno a esta suerte, y al examinar la evolución de vocablos de hoy podemos entrever sus vicisitudes y hasta rescatar significados sugestivos de nuevas perspectivas, como en las obras de los grandes artistas plásticos. Tal es el caso de los sustantivos que componen el título de esta nota, DERROTA y AGRONOMIA.

12.0pt; font-family: ";Arial";,";sans-serif";;"> 

Enfermedades diarreicas, infecciones respiratorias y características de la alimentación de los niños de 12 a 35 meses de edad en el Perú

Directory of Open Access Journals (Sweden)

Carlos Rojas D

2004-07-01

Full Text Available Objetivos: Describir las características de las prácticas de alimentación y cuantificar las enfermedades diarreicas agudas e infecciones respiratorias agudas en los niños de 12 a 35 meses en el Perú. Materiales y Métodos: La información formó parte de la Encuesta Nacional de Consumo de los Alimentos en Mujeres en Edad Fértil y Niños entre 12 y 35 meses en el año 2003. La muestra fue de 2908 niños (1514 varones y 1394 mujeres, cuyas madres fueron interrogadas sobre las características de alimentación complementaria. Resultados: A nivel nacional 21,2% de los niños presentó diarrea en las dos semanas anteriores a la encuesta, siendo las regiones de la selva las más afectadas. Además 17,1% de los niños en el país tuvo infección respiratoria aguda. A nivel nacional, la mediana de duración de lactancia materna exclusiva se dio a los 5 meses de edad. La mediana de duración total de lactancia materna a nivel nacional se dio a los 14 meses; mientras que la mediana de introducción de aguas azucaradas e infusiones a la alimentación infantil ocurrió a los 5 meses. La mediana de la frecuencia de alimentación fue de 4 veces al día. Además, 65,3% de las madres consideraron mejor ofrecer comidas espesas al niño. Aproximadamente 38% de las entrevistadas consideraron necesario agregar aceite a las preparaciones de los niños. Conclusiones: Existen aún elevadas prevalencias de enfermedades infecciosas, mientras que las características de alimentación del niño, aún no siguen los patrones recomendados, afectando la salud y nutrición de los niños del Perú.

CARACTERIZACIÓN DE LA PRODUCCIÓN DE LECHE DE LA CONEJA CON ENFASIS EN LA SUPERVIVENCIA Y CRECIMIENTO DE LA CAMADA EN RAZAS NUEVA ZELANDA BLANCO Y CALIFORNIA

Directory of Open Access Journals (Sweden)

Benjamin Gómez-Ramos

2010-10-01

Full Text Available El objetivo fue integrar los conocimientos sobre factores genéticos y ambientales que inciden en la producción de leche (PL de la coneja y su efecto en la supervivencia y crecimiento de la camada. Las investigaciones sugieren que la PL se relaciona con el crecimiento y supervivencia del gazapo durante las primeras tres semanas de vida. En cuanto a los aspectos genéticos, se ha estimado que existen diferencias en PL entre razas puras y sus cruzas, además de que el índice de herencia (h2 para PL en Nueva Zelanda Blanco, California y sus cruzas reciprocas es de 0.12%, lo cual establece un mayor efecto ambiental sobre PL. Al parecer la PL alcanza su máxima producción (219.6 g con 12 gazapos/camada y su pico de producción se alcanza al tercer parto y disminuye a partir del quinto parto. Sin embargo, la PL es determinada por: la condición fisiológica de la coneja -lactante-gestante (130 g/día o lactante-no gestante (141 g/día-; el número de pezones, conejas con 10 pezones produjeron 10% más leche que aquellas con 8; la temperatura ambiente, por cada grado centígrado por arriba de 20°C la PL disminuye 7.7 g/día. Los principales factores que influyen sobre la PL de la coneja no son atribuibles a esta. Por lo tanto, es importante controlar la naturaleza aleatoria de la mayoría de los factores no-genéticos que afectan a PL.

Informe sobre la alimentación de Tyto alba (Lechuza común) en Villacastín (Segovia) el 12 de abril de 1956

OpenAIRE

Valverde Gómez, José Antonio, 1926-2003

2008-01-01

Informe cuantitativo sobre la alimentación de Tyto alba (Lechuza común) en Villacastín (Segovia) el 12 de abril de 1956, a partir de diverso material encontrado en el desván de la iglesia del pueblo. Se observaron restos de insectos (fundamentalmente coleópteros y ortópteros), ranas, los siguientes mamíferos: Apodemus sp. (Ratón), Arvicola sapidus (Rata de agua, también llamado Ratón aguadero), Crocidura sp. (Musaraña) y "Pytimis" (llamado así por el autor, siendo posiblemente el actual géne...

Pensamiento del alumno sobre la educación física según la edad

Directory of Open Access Journals (Sweden)

Juan Antonio Moreno Murcia

2006-06-01

Full Text Available El pensamiento del alumno de Educación Secundaria Obligatoria hacia la Educación Física es un tema de gran interés entre los docentes. Existen numerosas variables que determinan dicho pensamiento. En nuestra investigación hemos analizado cómo se relaciona la edad (12-13 y 14-15 años del alumno con otros aspectos de la Educación Física: la importancia y el interés que el alumno concede a la Educación Física, la práctica físico-deportiva extraescolar y el contexto en el que se realiza dicha práctica (fe­derada o por su cuenta. Para ello hemos utilizado el Cuestionario para el Análisis del Pensamiento del Alumno en Educación Física (C.A.P.A.E.F. elaborado para esta investigación, aplicándolo a una muestra de 1499 estudiantes de primer y segundo ciclo de Enseñanza Secundaria Obligatoria de la Región de Murcia. Para el análisis de resultados hemos realizado estadísticos descriptivos de todas las variables, así como análisis de independencia entre variables mediante las pruebas de Chi-cuadrado de Pearson completada con análisis de residuos tipificados corregidos. Las principales conclusiones a las que hemos llegado han sido: la Educación Física gusta más a los alumnos de 12-13 años que a los de 14-15 años, encontrándola muy importante y útil, ya que les ayuda a relacionarse con lo demás y a ser más inteligentes. La Educación Física es ante todo competición y diversión, para los alumnos de 12-13 años, por ello los contenidos más importantes son la Condición Física y la Salud, los Juegos y Deportes y las Actividades en el medio natural, en cambio, la Expresión Corporal no recibe la misma consideración. A los alumnos de 12-13 años les gusta que el profesor sea bueno, alegre, justo, les anime, les corrija en clase y vista ropa deportiva.

Synthesis and optical properties of novel pyrido[1,2-a]benzimidazole-containing 1,3,4-oxadiazole derivatives

International Nuclear Information System (INIS)

Yang He; Ge Yanqing; Jia Jiong; Wang Jianwu

2011-01-01

A series of novel substituted 1,3,4-oxadiazole derivatives containing pyrido[1,2-a]benzimidazole moiety were synthesized and characterized using FTIR, 1 H NMR, 13 C NMR, and HRMS. An efficient tandem reaction was employed as a key step in constructing the pyrido[1,2-a]benzimidazole moiety under very mild condition. The structure of compound 4a was established by X-ray crystallography. The UV-vis absorption and fluorescence spectral characteristics of these compounds were investigated in several solvents. Compounds 4a-i display similar absorptions, with absorption peaks ranging from 330 to 339 nm in acetonitrile, while the absorption maxima of compound 4j bearing a diphenylamino group on the benzene ring is red-shifted distinctly to 377 nm due to the strong electron-donating property of its substituent and extended π-conjugated system. All these target heterocyclic compounds present blue-green emissions (461-487 nm) in dilute solutions and show high quantum yields of fluorescence (φ PL =0.65-0.99) in dichloromethane. - Research Highlights: → The first report about the unique optical properties of pyrido[1,2-a]benzimidazole heteroaromatic compounds containing 1,3,4-oxadiazole unit. → Synthesis of pyrido[1,2-a]benzimidazole moiety via a novel efficient tandem reaction. → The target heterocyclic compounds showing high quantum yields of fluorescence, with great potential for use as fluorescent pigments and in optical/electro devices.

Efecto de la Esplenectomia en la infección a Babesias de la ardilla Citellus Tridecemlineatus

Directory of Open Access Journals (Sweden)

Arístides Herrer

1956-07-01

Full Text Available Observaciones en el Citellus tridecemilineatus con infecciones latentes a babesias ponen de manifiesto que la esplenectomía desencadena una inusitada intensificación del parasitismo, marcada anemia y otras alteraciones que pueden conducir a la muerte del animal. De cifras inferiores a 1 por mil que usualmente se observa en las infecciones latentes, con la esplenectomía la parasitemia se intensifica en tal forma que en ciertas ocasiones suele comprender a algo más del 80 por ciento de los eritrocitos. De igual manera aumenta notablemente la intensidad con que son parasitados los hematies, verificándose después de la extirpación del bazo eritrocitos con 8, 10 y 12 parásitos. Los resultados de estos estudios señalan la enorme importancia que el bazo tendría en la defensa contra la infección latente de esta especie de babesia, de manera parecida a lo que sucede principalmente en las infecciones a bartonellas de ciertos animales.

Ressources vegetales de la foret classee de la lama et alimentation ...

African Journals Online (AJOL)

L'étude s'est déroulée dans la forêt classée de la Lama située entre 6°55-7°00N et 2°04-2°12 E. Elle a permis de mettre en exergue la diversité et la densité des ressources forestières alimentaires consommées par les populations des villages Holli et Fon vivant dans cette forêt. Au total, 45 espèces végétales sont ...

RENDIMIENTO DE 12 HÍBRIDOS COMERCIALES DE ZANAHORIA (Daucus carota L. EN EL CAMPO Y EN LA PLANTA DE EMPAQUE

Directory of Open Access Journals (Sweden)

Fernando Richmond-Zumbado

2010-01-01

Full Text Available Se evaluaron 12 híbridos comerciales de zanahoria (Daucus carota L. en Cot de Oreamuno, Cartago, Costa Rica, con el objetivo de evaluar el rendimiento en el campo y la planta de empaque, de junio a octubre del 2007. Los híbridos evaluados fueron: Bangor F1, Big Sur, Bolero F1, Concerto F1 (VAC 03 F1, XCR3688, Esperanza, Nandrin F1, Napoli F1, S-505, Spearhead, Trinity y Sirkana. Se obtuvo el número y peso de las raíces de los híbridos comerciales clasificadas en raíces totales, comerciales y diferentes variables de rechazo; en el campo y en la planta de empaque. Los híbridos con el mayor rendimiento comercial en campo y en planta empacadora, en orden decreciente, fueron: Bangor F1, Esperanza, Concerto F1, Nandrin F1 y Sirkana. Los materiales con menor rechazo en campo fueron Nandrin F1, Sirkana y Bangor F1, y en planta empacadora fueron: Big Sur, Sirkana, Napoli F1, Bolero F1 y XCR3688. Las principales causas de rechazo de la zanahoria en el campo y en la planta empacadora fueron: raíces bifurcadas, con rajadura, raíz pequeña y tamaño jumbo.

Propiedades psicométricas de la Escala de Satisfacción con la Vida en los Estudiantes (SLSS de Huebner en niños y niñas de 10 a 12 años de Chile

Directory of Open Access Journals (Sweden)

Jaime Alfaro

Full Text Available Este trabajo analiza las propiedades psicométricas de la escala SLSS de Huebner en una muestra de niños y niñas chilenos. Se aplicó a 1096 estudiantes de 10 a 12 años (M=11; DT= 0.89 que asistían a establecimientos municipales, particulares subvencionados y particulares pagados en las ciudades de Santiago, Valparaíso y Concepción. Se realizaron análisis de fiabilidad de consistencia interna, análisis factorial exploratorio (AFE y confirmatorio (AFE. Los resultados exhiben una aceptable fiabilidad en tanto consistencia interna de la escala (α=.86, el análisis factorial arroja dos factores en la estructura factorial de la escala que se corresponden con satisfacción con la vida y deseo de cambio. Se discute la solución bifactorial del modelo seleccionado en tanto no se corresponde con lo comunmente reportado en otras investigaciones. El estudio reporta resultados del uso de SLSS en población infantil y aporta al uso y desarrollo de herramientas de medición de autorreporte para el estudio del bienestar subjetivo en niños chilenos.

Synthesis and evaluation of antimalarial activity of curcumin derivatives; Sintese e avaliacao da atividade antimalarica de compostos derivados da curcumina

Energy Technology Data Exchange (ETDEWEB)

Gomes, Patricia Ramos; Miguel, Fabio Balbino; Almeida, Mauro Vieira de; Couri, Mara Rubia Costa [Universidade Federal de Juiz de Fora (UFSJ), MG (Brazil). Instituto de Ciencias Exatas. Departamento de Quimica; Oliveira, Michael Eder de; Ferreira, Vanessa Viana; Guimaraes, Daniel Silqueira Martins; Lima, Aline Brito de; Barbosa, Camila de Souza; Oliveira, Mariana Amorim de; Almeida, Mauro Vieira de; Viana, Gustavo Henrique Ribeiro; Varotti, Fernando de Pilla, E-mail: varotti@ufsj.edu.br [Universidade Federal de Sao Joao Del Rei (UFSJ), MG (Brazil). Centro de Ciencias da Saude; others, and

2014-05-15

ne of the main challenges in the development of new antimalarial drugs is to achieve a viable lead candidate with good pharmacokinetic properties. Curcumin has a broad range of biological activities, including antimalarial activity. Herein, we report the antimalarial activity of six curcumin derivatives (6-12) and an initial analysis of their pharmacokinetic properties. Five compounds have demonstrated potent activity against the P. falciparum in vitro (IC{sub 50} values ranging from 1.7 to 15.2 μg mL{sup -1}), with moderate or low cytotoxicity against the HeLa cell line. The substitution of the carbonyl group in 6 by a 2,4-dinitrophenylhydrazone group (to afford 11) increases the Selective Index. These preliminary results indicate curcumin derivatives as potential antimalarial compounds. (author)

La corte constitucional: entre la ley de gradualidad y la gradualidad de la ley. A propósito del fallo sobre el aborto

OpenAIRE

Ilva Myriam Hoyos

2006-01-01

El artículo, escrito un mes después de proferido el fallo de la Corte Constitucional sobre el aborto, presenta algunas reflexiones críticas sobre el polémico fallo. La tesis central que desarrolla, con base en los comunicados de prensa del 11 y 12 de mayo de 2006, y en las declaraciones de prensa de una de las demandantes y del magistrado ponente, es que, a diferencia de lo que sostiene la Corte, en Colombia se legalizó el aborto en tres amplios supuestos. Esa legalización i...

La responsabilidad del Contador Público en empresas imputadas por delitos tipificados en la Ley Penal Tributaria

OpenAIRE

Rossana Greco; Oscar Nedel

2013-01-01

El objeto de estudio del presente trabajo es la responsabilidad del contador público en su actuación como auditor externo de estados contables, en el marco de la ley penal tributaria y previsional, teniendo en cuenta la modificación de la ley 24.769 introducida por la ley 26.735 (BO: 28.12.2011) que incorpora el concepto de responsabilidad empresarial, aceptando como sujeto no solo a la persona física, sino que también a la persona jurídica. La metodología utilizada se basó en la revisión doc...

La investigación - acción en el contexto de la Educación Musical

Directory of Open Access Journals (Sweden)

Jimeno, María Manuela

2000-05-01

Full Text Available Investigación que propone un marco para adecuar, organizar, estructurar e interrelacionar los "Curriculum" de Escuelas de Música (3-12 años y Educación Musical en: Educación Infantil y Primaria (3-12 años, analizando convergencias y divergencias, fundamentando la música en su dualidad de Ciencia y Arte. Dicha investigación dirigida por Mª Manuela Jimeno, ha sido realizada con la participación de un equipo de profesores de Educación Infantil y Primaria así como de Escuelas de Música.La investigación que presentamos se está llevando a cabo en estos momentos en varios Centros de la Comunidad Foral de Navarra bajo el Patrocinio del Gobierno de Navarra, Departamento de Educación y Cultura. El planteamiento Teórico y Análisis de las propuestas se lleva a cabo en la Universidad Pública de Navarra, desde 1995 hasta la fecha.La finalidad de este proyecto pedagógico-musical es conseguir para los niños/as entre 3 y 12 años una cultura y formación musical equilibradas, el acercamiento más profundo al hecho musical, apostando por la unidad y convergencia de los "Currículos" como eje vertebrador, con la doble finalidad de servir de formación básica para unos, y como formación y preparación más específica, para aquellos otros que posean aptitudes para optar a las pruebas de grado medio de las Enseñanzas regladas de Música, o servir de fundamento para la apertura hacia otros itinerarios de expresión ARTÍSTICA.El planteamiento de la investigación que presentamos nos brinda la oportunidad de reflexionar y analizar sobre:Nuestra concepción del alumno/a. Nuestra concepción de Investigación Ecológica y la situación de la Investigación en la Acción. Las hipótesis de Trabajo. Como realizamos una sesión práctica. El Modelo creado que se sigue en la Investigación. Valoración de Datos y Conclusiones obtenidas hasta la fecha.

The crystal structure of Cu_1.6Pb_1.6Bi_6.4S₁₂, a new 44.8 Å derivative of the bismuthinite-aikinite solid-solution series

DEFF Research Database (Denmark)

Topa, Dan; Balic-Zunic, Tonci; Makovicky, Emil

2000-01-01

Cu1.6Pb1.6Bi6.4S12, aikinite-bismuthinite derivative, crystal structure, Felbertal, scheelite deposit, Austria......Cu1.6Pb1.6Bi6.4S12, aikinite-bismuthinite derivative, crystal structure, Felbertal, scheelite deposit, Austria...

Alteration of rare-earth-metal cluster iodides R(R6I12Z) through cation substitution

International Nuclear Information System (INIS)

Jensen, E.A.; Corbett, J.D.

2003-01-01

Four examples of (A x R 1-x )R 6 I 12 Z phases further illustrate the flexibility of the rhombohedral R 7 X 12 Z structure to substitution of heterocations for the isolated R III atoms without destruction of the structure. The examples with R=La, Pr, Z=Fe, Co, Ir, and stoichiometric amounts of A=Na or Ca were prepared by traditional high temperature techniques and characterized by single crystal and Guinier powder X-ray diffraction techniques. Product compositions refined in the parent space group R3-bar from reactions of stoichiometry AR 6 I 12 Z were (Na 0.90 Pr 0.10 )Pr 6 I 12 Ir, (Na 0.954 La 0.046 )La 6 I 12 Fe, and (Ca 0.801 La 0.199 )La 6 I 12 Co. More general characteristics of and trends in the family of R 7 X 12 Z structures are also considered, including distortions of the ideal motif as a function of extremes in the components

Evaluación de la definición clínica de dengue sugerida por la Organización Mundial de la Salud.

OpenAIRE

Ruth Aralí Martínez; Fredi Alexander Díaz; Luis Angel Villar

2005-01-01

Introducción. Clínicamente es difícil diferenciar el dengue de otras entidades con sintomatología similar. Objetivo. Evaluar la utilidad diagnóstica de la definición de caso presunto de dengue sugerida por la Organización Mundial de la Salud, en un área endémica (Bucaramanga, Colombia). Materiales y métodos. En una cohorte con síndrome febril agudo sin causa aparente (mayores de 12 años), se determinó la sensibilidad, la especificidad y los valores pronósticos de dicha definición que incluye ...

TRATAMIENTO PENITENCIARIO EN LA PROVINCIA DE BUENOS AIRES EL DESAFÍO DE AJUSTAR LA LEGISLACIÓN A LA PRÁCTICA INTERNACIONAL.

Directory of Open Access Journals (Sweden)

Fabián A. Quintero

2011-05-01

Full Text Available El tratamiento penitenciario en la Provincia de Buenos Aires (Argentina seencuentra normado por la ley 12.256 en forma genérica. Dicha norma nodiferencia entre las condiciones generales para garantizar la factibilidad deltratamiento penitenciario y los objetivos y alcances del tratamiento en sí mismo.Diferenciando tres aspectos de la función penitenciaria a saber, el tratamiento penitenciario, la asistencia penitenciaria y la preservación de los derechos en los sujetos privados de la libertad, se pretende analizar los actuales instrumentos que instaura la legislación y consecuentemente postular posibles ajustes a la normativa internacional. Se colige, de un análisis comparado, la necesidad de modificaciones que permitan definir el objeto de intervención, delimitar los objetivos y sus alcances, determinar las condiciones de base para la intervencióny garantizar evaluaciones a largo plazo, corrigiendo así la miopía estructural del programa institucional penitenciario.

Influence of the addition of Lactobacillus acidophilus La-05, Bifidobacterium animalis subsp. lactis Bb-12 and inulin on the technological, physicochemical, microbiological and sensory features of creamy goat cheese.

Science.gov (United States)

Barbosa, Ilsa C; Oliveira, Maria E G; Madruga, Marta S; Gullón, Beatriz; Pacheco, Maria T B; Gomes, Ana M P; Batista, Ana S M; Pintado, Maria M E; Souza, Evandro L; Queiroga, Rita C R E

2016-10-12

The effects of the addition of Lactobacillus acidophilus LA-05, Bifidobacterium animalis subsp. lactis BB-12 and inulin on the quality characteristics of creamy goat cheese during refrigerated storage were evaluated. The manufactured cheeses included the addition of starter culture (Lactococcus lactis subsp. lactis and Lactococcus lactis subsp. cremoris - R-704) (CC); starter culture, L. acidophilus LA-05 and inulin (CLA); starter culture, B. lactis BB-12 and inulin (CBB); or starter culture, L. acidophilus LA-05, B. lactis BB-12 and inulin (CLB). In the synbiotic cheeses (CLA, CBB and CLB), the counts of L. acidophilus LA-05 and B. lactis BB-12 were greater than 6log CFU g -1 , the amount of inulin was greater than 6 g per 100 g, and the firmness was reduced. The cheeses evaluated had high brightness values (L*), with a predominance of yellow (b*). CC had higher contents of proteins, lipids and minerals compared to the other cheeses. There was a decrease in the amount of short-chain fatty acids (SCFAs) and an increase of medium-chain (MCFAs) and long-chain fatty acids (LCFAs) in the synbiotic cheeses compared to CC. The amount of conjugated linoleic acid increased in CLA, CBB and CLB. The highest depth of proteolysis and the greatest changes in the release of free amino acids were found in CLB. The addition of inulin and probiotics, alone or in co-culture, did not affect the cheese acceptance. Inulin and probiotics can be used together for the production of creamy goat cheese without negatively affecting the general quality characteristics of the product, and to add value because of its synbiotic potential.

PAPEL DE LOS HEMICANALES FORMADOS POR LA PANEXINA1 Y DEL ATP EXTRACELULAR DURANTE LA ADQUISICION DEL COMPROMISO MIOGENICO Y LA POTENCIACION DE LA CONTRACCION MUSCULAR ESQUELETICA ADULTA.

OpenAIRE

RIQUELME PEREZ, MANUEL ANTONIO; RIQUELME PEREZ, MANUEL ANTONIO

2010-01-01

En la ontogenia y estado adulto del músculo esquelético numerosas funciones 2+ dependen de incrementos de la concentracion intracelular de Ca 2- libre ([Ca ]'). Concordantemente, las células C 2C 12 de reserva (CR), modelo in vitro de células precursoras 110p.

Complete fusion of the 12C+12O, 14N+12C and 15N+12C systems

International Nuclear Information System (INIS)

Conjeaud, M.; Gary, S.; Harar, S.; Wieleczko, J.P.

1978-01-01

Cross sections for evaporation residues following the complete fusion of the 12 C+ 12 C, 14 N+ 12 C and 15 N+ 12 C systems have been measured with a E-ΔE counter telescope in a wide range of incident energies. They are fairly well reproduced by evaporation calculations based on the statistical theory. The total fusion excitation function of the 12 C+ 12 C system shows strong structure, which is compared to the predictions of the reaction cross sections derived from coupled channel calculations and to the integrated inelastic cross sections. Critical angular momenta have been obtained from the fusion cross-section data and these values are discussed in the framework of compound nucleus and entrance channel effects. A striking difference is observed between the fusion cross sections of the 14 N+ 12 C and 15 N+ 12 C systems and shows the importance of the valence nucleons of colliding ions in the fusion process. A possible interpretation might be the influence of the yrast line of the compound nuclei. (Auth.)

32 CFR 2400.16 - Derivative classification markings.

Science.gov (United States)

2010-07-01

... SECURITY PROGRAM Derivative Classification § 2400.16 Derivative classification markings. (a) Documents... 32 National Defense 6 2010-07-01 2010-07-01 false Derivative classification markings. 2400.16..., as described in § 2400.12 of this part, the information may not be used as a basis for derivative...

High magnetic ordering temperature in the perovskites Sr{sub 4-x}La{sub x}Fe{sub 3}ReO{sub 12} (x=0.0, 1.0, 2.0)

Energy Technology Data Exchange (ETDEWEB)

Retuerto, M.; Li, M.-R.; Go, Y.B. [Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, 610 Taylor Road, Piscataway, NJ 08854 (United States); Ignatov, A.; Croft, M. [Department of Physics and Astronomy, Rutgers, The State University of New Jersey, 136 Frelinghuysen Road, Piscataway, NJ 08854 (United States); Ramanujachary, K.V. [Department of Chemistry and Physics, Rowan University, 210 Mullica Hill Road, Glassboro, NJ 08028 (United States); Herber, R.H.; Nowik, I. [Racah Institute of Physics, Hebrew University, Jerusalem, 91904 Israel (Israel); Hodges, J.P. [Spallation Neutron Source, Oak Ridge National Laboratory, Oak Ridge, TN 37831 (United States); Dachraoui, W.; Hadermann, J. [EMAT, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp (Belgium); Greenblatt, M., E-mail: martha@rutchem.rutgers.edu [Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, 610 Taylor Road, Piscataway, NJ 08854 (United States)

2012-10-15

A series of perovskites Sr{sub 4-x}La{sub x}Fe{sub 3}ReO{sub 12} (x=0.0, 1.0, 2.0) has been prepared by wet chemistry methods. The structure analyses by powder X-ray and neutron diffraction and electron microscopy show that these compounds adopt simple perovskite structures without cation ordering over the B sites: tetragonal (I4/mcm) for x=0.0 and 1.0 and orthorhombic (Pbmn) for x=2.0. The oxidation states of the cations in the compound with x=0.0 appear to be Fe{sup 3+/4+} and Re{sup 7+} and decrease for both with La substitution as evidenced by X-ray absorption spectroscopy. All the compounds are antiferromagnetically ordered above room temperature, as demonstrated by Moessbauer spectroscopy and the magnetic structures, which were determined by powder neutron diffraction. The substitution of Sr by La strongly affects the magnetic properties with an increase of T{sub N} up to {approx}750 K. - Graphical abstract: High resolution transmission electron microscopy image of Sr{sub 4-x}La{sub x}Fe{sub 3}ReO{sub 12} (x=2.0), showing twin domains. Fourier transforms are given of the areas indicated by the circles. Highlights: Black-Right-Pointing-Pointer Sr{sub 4-x}La{sub x}Fe{sub 3}ReO{sub 12} (x=0.0, 1.0, 2.0) perovskites prepared by wet chemistry. Black-Right-Pointing-Pointer PXD, PND, ED, indicate no cation ordering, I4/mcm) for x=0.0, 1.0, Pbmn for x=2. Black-Right-Pointing-Pointer XAS show oxidation states Fe{sup 3+/4+} and Re{sup 7+}; both decrease with increasing x. Black-Right-Pointing-Pointer All order antiferromagnetically above RT, with highest T{sub N} {approx}750 K.

La agonía de Magda Portal: Entre la Poesía Vanguardista y la Política Nacionalista

Directory of Open Access Journals (Sweden)

Youngkyun Choi

2015-09-01

Full Text Available El presente artículo trata de Magda Portal, mujer intelectual del Perú a comienzos del siglo XX. Fue una de pocas mujeres que publicaron poemas y ensayos en la revista literaria Amauta, de José Carlos Mariátegui. También desempeñó un papel importante en la APRA, partido nacionalista dirigido por Víctor Raúl Haya de la Torre. Sin embargo, existe cierta ruptura entre su mundo de artista literaria y el de aprista política, dado que Portal dejó de escribir poesía cuando decidió afiliarse a la APRA, alejándose de Mariátegui. Este hecho constituye la pregunta central del presente artículo: la conciliación y el choque entre la poética vanguardista, la idea feminista y la política nacionalista. En los poemas recopilados en Una esperanza y el mar (1927 de Magda Portal, se observan la deconstrucción del yo poético y la impureza de la vida. La poeta tuvo que abandonar el mundo ambiguo e inseguro, que refleja la poética vanguardista, para trasladarse a la tierra de la doctrina única y nacionalista de la APRA. En contraste con sus poemas, el folleto aprista El aprismo y la mujer (1933 construye y consolida la nueva identidad llamada “mujer nueva”, como resultado de la negociación con el nacionalismo para movilizar a las mujeres “colaboradoras” en el movimiento aprista. El pacto con los nacionalistas resultó vano y derivó en una tragedia de traición. Fracaso inevitable al intentar crear una figura femenina basada en el marco nacionalista que es esencialmente masculino.

Novedades nomenclaturales en la tribu Stipeae (Poaceae, Pooideae para la Flora Argentina

Directory of Open Access Journals (Sweden)

Ana María Cialdella

2010-01-01

Full Text Available Durante la revisión de los géneros de Stipeae (Poaceae para la flora argentina y de acuerdo a los últimos estudios filogenéticos en la tribu, se confirmó la necesidad de transferir algunos taxones recientemente descriptos de Stipa a Nassella, Jarava o Pappostipa. En este trabajo se presentan 12 nuevas combinaciones: Jarava ichu var. pungens, Nassella brachyglumis, N. macrotricha, Pappostipa arenicola, P. choconensis, P. colloncurensis, P. frigida var. longifolia, P. jucunda, P. kieslingii, P. mapuche, P. marqueziana y P. zulmae. Se incluye también una clave para identificar los géneros de Stipeae en la Argentina.

Collective Dynamics and Strong Pinning near the Onset of Charge Order in La1.48Nd0.4Sr0.12CuO4

Science.gov (United States)

Baity, P. G.; Sasagawa, T.; Popović, Dragana

2018-04-01

The dynamics of charge-ordered states is one of the key issues in underdoped cuprate high-temperature superconductors, but static short-range charge-order (CO) domains have been detected in almost all cuprates. We probe the dynamics across the CO (and structural) transition in La1.48Nd0.4Sr0.12CuO4 by measuring nonequilibrium charge transport, or resistance R as the system responds to a change in temperature and to an applied magnetic field. We find evidence for metastable states, collective behavior, and criticality. The collective dynamics in the critical regime indicates strong pinning by disorder. Surprisingly, nonequilibrium effects, such as avalanches in R , are revealed only when the critical region is approached from the charge-ordered phase. Our results on La1.48Nd0.4Sr0.12CuO4 provide the long-sought evidence for the fluctuating order across the CO transition, and also set important constraints on theories of dynamic stripes.

Endogenous protection derived from activin A/Smads transduction loop stimulated via ischemic injury in PC12 cells.

Science.gov (United States)

Mang, Jing; Mei, Chun-Li; Wang, Jiao-Qi; Li, Zong-Shu; Chu, Ting-Ting; He, Jin-Ting; Xu, Zhong-Xin

2013-10-17

Activin A (ActA), a member of transforming growth factor-beta (TGF-b) super- family, affects many cellular processes, including ischemic stroke. Though the neuroprotective effects of exogenous ActA on oxygen-glucose deprivation (OGD) injury have already been reported by us, the endogenous role of ActA remains poorly understood. To further define the role and mechanism of endogenous ActA and its signaling in response to acute ischemic damage, we used an OGD model in PC12 cells to simulate ischemic injury on neurons in vitro. Cells were pre-treated by monoclonal antibody against activin receptor type IIA (ActRII-Ab). We found that ActRII-Ab augments ischemic injury in PC12 cells. Further, the extracellular secretion of ActA as well as phosphorylation of smad3 in PC12 cells was also up-regulated by OGD, but suppressed by ActRII-Ab. Taken together, our results show that ActRII-Ab may augment ischemic injury via blocking of transmembrane signal transduction of ActA, which confirmed the existence of endogenous neuroprotective effects derived from the ActA/Smads pathway. ActRIIA plays an important role in transferring neuronal protective signals inside. It is highly possible that ActA transmembrance signaling is a part of the positive feed-back loop for extracellular ActA secretion.

Endogenous Protection Derived from Activin A/Smads Transduction Loop Stimulated via Ischemic Injury in PC12 Cells

Directory of Open Access Journals (Sweden)

Zhong-Xin Xu

2013-10-01

Full Text Available Activin A (ActA, a member of transforming growth factor-beta (TGF-b super- family, affects many cellular processes, including ischemic stroke. Though the neuroprotective effects of exogenous ActA on oxygen-glucose deprivation (OGD injury have already been reported by us, the endogenous role of ActA remains poorly understood. To further define the role and mechanism of endogenous ActA and its signaling in response to acute ischemic damage, we used an OGD model in PC12 cells to simulate ischemic injury on neurons in vitro. Cells were pre-treated by monoclonal antibody against activin receptor type IIA (ActRII-Ab. We found that ActRII-Ab augments ischemic injury in PC12 cells. Further, the extracellular secretion of ActA as well as phosphorylation of smad3 in PC12 cells was also up-regulated by OGD, but suppressed by ActRII-Ab. Taken together, our results show that ActRII-Ab may augment ischemic injury via blocking of transmembrane signal transduction of ActA, which confirmed the existence of endogenous neuroprotective effects derived from the ActA/Smads pathway. ActRIIA plays an important role in transferring neuronal protective signals inside. It is highly possible that ActA transmembrance signaling is a part of the positive feed-back loop for extracellular ActA secretion.

Peniciadametizine A, a Dithiodiketopiperazine with a Unique Spiro[furan-2,7'-pyrazino[1,2-b][1,2]oxazine] Skeleton, and a Related Analogue, Peniciadametizine B, from the Marine Sponge-Derived Fungus Penicillium adametzioides

Directory of Open Access Journals (Sweden)

Yang Liu

2015-06-01

Full Text Available Peniciadametizine A (1; a new dithiodiketopiperazine derivative possessing a unique spiro[furan-2,7'-pyrazino[1,2-b][1,2]oxazine] skeleton, together with a highly oxygenated new analogue, peniciadametizine B (2; as well as two known compounds, brasiliamide A (3; and viridicatumtoxin (4, were isolated and identified from Penicillium adametzioides AS-53, a fungus obtained from an unidentified marine sponge. The unambiguous assignment of the relative and absolute configuration for the spiro center C-2 of compound 1 was solved by the combination of NMR and ECD measurements with Density-Functional Theory (DFT conformational analysis and Time-Dependent Density-Functional Theory-Electronic Circular Dichroism (TDDFT-ECD calculations. The spiro[furan-2,7'-pyrazino[1,2-b][1,2]oxazine] skeleton of 1 has not been reported yet among natural products and the biosynthetic pathway for 1 and 2 was discussed. Compounds 1 and 2 showed inhibitory activity against the pathogenic fungus Alternaria brassicae.

12/15 lipoxygenase regulation of colorectal tumorigenesis is determined by the relative tumor levels of its metabolite 12-HETE and 13-HODE in animal models

OpenAIRE

Chang, Jian; Jiang, Li; Wang, Yinqiu; Yao, Bing; Yang, Shilin; Zhang, Bixiang; Zhang, Ming-Zhi

2014-01-01

Colorectal cancer (CRC) continues to be a major cause of morbidity and mortality. The arachidonic acid (AA) pathway and linoleic acid (LA) pathway have been implicated as important contributors to CRC development and growth. Human 15-lipoxygenase 1 (15-LOX-1) converts LA to anti-tumor 13-S-hydroxyoctadecadienoic acid (13-HODE)and 15-LOX-2 converts AA to 15-hydroxyeicosatetraenoic acid (15-HETE). In addition, human 12-LOX metabolizes AA to pro-tumor 12-HETE. In rodents, the function of 12-LOX ...

Construction of a bi parametric analysis system. Application to the study of the decay of the 16.11 MeV level of {sup 12}C; Realisation d'un ensemble d'analyse biparametrique. Application a l'etude de la desintegration du niveau de 16,11 MeV du {sup 12}C

Energy Technology Data Exchange (ETDEWEB)

Engelhardt, H D [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

1966-11-15

A baroreceptor analysis system has been assembled to measure {alpha}-{alpha} spectra in coincidence (resolution 2 {tau} = 10 ns). The correlations in energy and angle of the {alpha}-particles emitted from the reaction {sup 11}B(p,{alpha}) have been studied using 163 keV protons produced by a Van-de-Graaff accelerator. Evidence has been obtained for the sequential decay of {sup 12}C{sup *} (16.11 MeV) via the 0{sup +} and 2{sup +} states of {sup 8}Be. Contributions from the {sup 8}Be{sup *}(4{sup +}) level or from the simultaneous break-up of {sup 12}C{sup *} (16.11 MeV) into three {alpha}-particles cannot be excluded. (author) [French] On a mis au point un dispositif d'analyse biparametrique de spectres {alpha}-{alpha} en coincidences (resolution 2 {tau} = 10 ns). On a etudie, a l'aide de ce dispositif et d'un accelerateur Van de Graaff la correlation d'energie et angulaire entre les particules a de la reaction {sup 11}B(p,{alpha}) a une energie de protons E{sub p} = 163 keV. On a mis en evidence la desintegration sequentielle du {sup 12}C{sup *} (16.11 MeV) par les etats (0{sup +} et 2{sup +}) du {sup 8}Be. La contribution d'un niveau (4{sup +}) du {sup 8}Be{sup *} ou d'une desintegration simultanee du {sup 12}C{sup *} (16,11 MeV) en 3 {alpha} ne peut pas etre exclue. (auteur)

1-(2-Chlorobenzyloxy-3-[1,2,3]triazol-1-yl-propan-2-ol Derivatives: Synthesis, Characterization, and DFT-Based Descriptors Analysis

Directory of Open Access Journals (Sweden)

Eloisa Román-Maldonado

2017-01-01

Full Text Available A novel series of 1-(2-chlorobenzyloxy-3-[1,2,3]triazol-1-yl-propan-2-ol derivatives was designed and synthesized using copper catalyzed alkyne-azide cycloaddition in the key step. Theoretical investigation of molecular and electronic properties by means of global and local reactivity indexes of the synthetized compounds was carried out, using DFT (Density Functional Theory at PBEPBE/6-31++G⁎⁎ level.

Síndrome de Brown: A propósito de 12 casos Brown's syndrome: Apropos of 12 cases

Directory of Open Access Journals (Sweden)

Alina Pedroso Llanes

2004-06-01

Full Text Available Se realizó un estudio descriptivo retrospectivo de 12 pacientes con diagnóstico de síndrome de Brown, que asistieron a la Consulta de Oftalmología Pediátrica y Estrabismo del Hospital Oftalmológico Docente "Ramón Pando Ferrer" desde enero del 1999 a enero de 2000 con los objetivos de precisar la frecuencia del ojo afectado y el grado de severidad del síndrome, identificar los síntomas presentes que motivaron la consulta, determinar los criterios que decidieron la intervención quirúrgica y describir las desviaciones horizontales y verticales asociadas. En la muestra estudiada el 50 % de los pacientes tenían afectación del ojo derecho, el 70 % de los casos presentaban un estadio ligero de la enfermedad, la limitación de la elevación en aducción estuvo presente en el 100 % de los casos, el 30 % de los pacientes tuvieron criterio quirúrgico y el 90 % presentaban desviaciones asociadasA descriptive retrospective study was conducted among 12 patients that were diagnosed Brown's syndrome and who were seen at the Pediatric Ophthalmology and Strabismus Office of "Ramón Pando Ferrer" Ophthalmological Teaching Hospital from January 1999 to January 2000 in order to determine the frequency of the affected eye and the severity degree, to identify the symptoms that motivated the visit, to determine the criteria that decided the surgical procedure and to describe the associated horizontal and vertical deviations. In the studied sample, 50 % of the patients had the right eye affected and 70 % of the cases presented a mild state of the disease. The limitation of the elevation in abduction was present in 100 % of the cases, 30 % of the cases had surgical criterion and 90 % presented associated deviations

Electrochemical Stability of Li6.5La3Zr1.5M0.5O12 (M = Nb or Ta) against Metallic Lithium

International Nuclear Information System (INIS)

Kim, Yunsung; Yoo, Aeri; Schmidt, Robert; Sharafi, Asma; Lee, Heechul; Wolfenstine, Jeff; Sakamoto, Jeff

2016-01-01

The electrochemical stability of Li 6.5 La 3 Zr 1.5 Nb 0.5 O 12 (LLZNO) and Li 6.5 La 3 Zr 1.5 Ta 0.5 O 12 (LLZTO) against metallic Li was studied using direct current (DC) and electrochemical impedance spectroscopy (EIS). Dense polycrystalline LLZNO (ρ = 97%) and LLZTO (ρ = 92%) were made using sol–gel synthesis and rapid induction hot-pressing at 1100°C and 15.8 MPa. During DC cycling tests at room temperature (± 0.01 mA/cm 2 for 36 cycles), LLZNO exhibited an increase in Li–LLZNO interface resistance and eventually short-circuiting while the LLZTO was stable. After DC cycling, LLZNO appeared severely discolored while the LLZTO did not change in appearance. We believe the increase in Li–LLZNO interfacial resistance and discoloration are due to reduction of Nb 5+ to Nb 4+ . The negligible change in interfacial resistance and no color change in LLZTO suggest that Ta 5+ may be more stable against reduction than Nb 5+ in cubic garnet versus Li during cycling.

Effect of La-CO substitution on the crystal structure and magnetic properties of low temperature sintered Sr1-xLaxFe12-xCoxO19 (x=0-0.5) ferrites

Science.gov (United States)

Peng, Long; Li, Lezhong; Wang, Rui; Hu, Yun; Tu, Xiaoqiang; Zhong, Xiaoxi

2015-11-01

The La-Co substituted Sr1-xLaxFe12-xCoxO19 (x=0-0.5) ferrites with appropriate Bi2O3 additive were prepared at a low sintering temperature of 890 °C compatible with LTCC (low temperature co-fired ceramics) systems, and the effect of La-Co substitution on their crystal structure and magnetic properties was investigated. The results show that the pure M-type phase is successfully obtained when the La-Co substitution amount x does not exceed 0.3. However, the single M-type phase structure transforms to multiphase structure with further increased x, where the α-Fe2O3 phase and La2O3 phase coexist with the M-type phase. Moreover, the saturation magnetization Ms, magnetic anisotropy field Ha, intrinsic coercivity Hci, and Curie temperature TC of the ferrites depend on the La-Co substitution amount strongly, which are suggested to be determined by the partially substitution of La3+-Co2+ ions for Sr2+-Fe3+ ions with x not higher than 0.3. It is found that the obtained Sr1-xLaxFe12-xCoxO19 (x=0.2 and 0.3) ferrites can provide improved magnetic properties (Ms>62 emu/g, Ha>1400 kA/m, and Hci>320 kA/m) as low temperature sintered M-type hexaferrites for microwave LTCC applications.

Induction of the lambda bacteriophage synthesis in Escherichia coli K 12 by polonium alpha rays; Induction de la synthese du bacteriophage lambda chez Escherichia coli K 12 par les rayons alpha du polonium

Energy Technology Data Exchange (ETDEWEB)

Devoret, Raymond

1958-06-15

This research thesis reports the study of the inducing action of polonium alpha radiations in Escherichia Coli K 12 by using an external irradiation device. This work comprised the development of a method to spread bacteria in layer with a thickness less than 20 microns, and the measurement of the number of α particles falling on the irradiated surface. This measurement has been performed by using a nuclear emulsion and a simple photographic film. It appears that alpha radiations have an inducing action, and that at most 15 per cent of bacteria can be induced. The comparison of the induction curve with the survival curves of lysogen and sensitive stains shows that there is no abortive induction. Thus, it appears that this inducing action is not due to an indirect effect of the irradiated medium [French] Dans ce travail on a etudie l'action inductrice des rayons alphas du polonium chez Escherichia Coli K 12 par un diapoaitif d'irradiation externe. Son utilisation necessitait: - une methode d'etalement des bacteries en couche de moins de 20 microns d'epaisseur; - une mesure du nombre des particules alpha tombant sur la surface etendue irradiee. Les mesures ont ete faites a l'aide d'une emulsion nucleaire et d'un film photographique ordinaire. 1) Les rayons alphas ont une action inductrice. Au plus 15 pc des bacteries peuvent etre induites. 2) La oomparaison de la courbe d'induction et des courbes de survie des souches lysogene et sensible montre qu'il n'y a pas d'inductions abortives. 3) Cette action inductrice n'est pas due a un effet indirect du milieu irradie. (auteur)

Influencia del probiótico Sorbifauna en la producción y calidad de la leche de vacas mestizas en pastoreo

Directory of Open Access Journals (Sweden)

Tania Sánchez

Full Text Available El objetivo de la investigación fue evaluar la inclusión del probiótico Sorbifauna en la producción y calidad de la leche de vacas Holstein × Cebú que pastoreaban en una asociación de Leucaena leucocephala cv. Cunningham y Megathyrsus maximus cv. Likoni; el estudio se realizó en el periodo mayo-junio de 2013, en la Estación Experimental de Pastos y Forrajes Indio Hatuey. Se utilizaron 12 vacas (clínicamente sanas en un diseño Switch Back, con tres tratamientos: A: pastoreo en la asociación + 60 g de aditivo, B: pastoreo en la asociación + 90 g de aditivo, y C: pastoreo en la asociación + 120 g de aditivo. Se estimó la disponibilidad de pasto y se midió la producción de leche durante el experimento, para lo que se tuvo en cuenta la producción promedio inicial (10,0 ± 2,2 kg, en 84 ± 54 días de lactancia. Además, se determinaron los porcentajes de grasa, proteína, lactosa y sólidos totales. La producción de leche fue de 11,9; 12,1 y 12,2 kg/vaca/día, sin diferencias significativas entre los tratamientos, al igual que para la grasa (3,8; 4,0 y 3,9 % y la proteína (3,3; 3,4 y 3,4 %; en la lactosa y los sólidos totales se obtuvo un comportamiento similar. Se concluye que no hubo diferencias significativas en la producción y calidad de la leche en vacas de mediano potencial al incluir el probiótico Sorbifauna cuando estas pastan en un sistema silvopastoril, por lo que se recomienda evaluarlo en sistemas de gramíneas sin fertilizar.

The dam in Garganta del Ciervo, 12th century (Segura de la Sierra, Jaén, España: contributions to Andalusian hydraulic engineering | La presa de la Garganta del Ciervo, s. XII (Segura de la Sierra, Jaén, España: aportaciones a la ingeniería hidráulica andalusí

Directory of Open Access Journals (Sweden)

Vicente Salvatierra Cuenca

2016-12-01

Full Text Available In this text we analyze a remarkable Islamic dam located in Sierra de Segura, dated from the 12th century. The size of the dam, 11 m high and 9 m thick, its location in a mostly flat area, the technique used to build it, the reservoir that it created, etc. makes dams a very singular element among the irrigation architecture in Al-Andalus. In addition to describing the dam, we also intend to discuss to which point the purpose of this structure was truly different from what was usually done at that time, and, therefore, if it means both a technological and social change, or if its configuration hid other objectives. | En este texto analizamos una notable presa islámica localizada en la Sierra de Segura, fechada en el siglo XII. Su envergadura, 11 m de altura y 9 m de grosor, su situación en una zona sustancialmente llana, su técnica de fabricación, el pantano que generaba, etc. la convierten en principio en un elemento muy atípico dentro de la arquitectura de regadío andalusí. Además de realizar su descripción, nos proponemos discutir hasta qué punto la finalidad de esta estructura era realmente diferente a lo que se hacía en la época, y si supone por tanto un cambio tecnológico y social. O si su configuración escondía otros objetivos.

De ciudades saludables a ciudades sostenibles: la experiencia de Castilla-La Mancha en la Agenda Local 21

Directory of Open Access Journals (Sweden)

Francisco Javier Santamarta Álvarez

2005-12-01

Full Text Available La cumbre de la Tierra celebrada en Río de Janeiro, en 1992, hace un llamamiento a las autoridades locales para que elaboren la Agenda 21 Local. Posteriormente, la I Conferencia Europea de Ciudades Sostenibles, celebrada en Aalborg en 1994, crea la Campaña de Ciudades Europeas Sostenibles.En Castilla-La Mancha se había creado ya en 1991 la Red de Ciudades Saludables de Castilla-La Mancha. En un principio esta red estaba formada por nueve ciudades que se comprometieron a desarrollar el proyecto de la Organización Mundial de la Salud (OMS, Ciudades Saludables. Durante los 12 años de la Red de Ciudades Saludables se editaron nueve boletines, se realizaron cinco congresos regionales y se presentó el libro La Red de Ciudades Saludables de Castilla-La Mancha 1991-2002. Esta red llegó a tener 100 municipios integrados, que eran gestionados por 30 coordinadores.Con la creación, en el año 2003, de la Consejería de Medio Ambiente, la red se transformó e integró en la Red de Ciudades y Pueblos Sostenibles de Castilla-La Mancha. En la actual Red se suman la larga experiencia de la Red de Ciudades Saludables de Castilla-La Mancha con la más reciente de la Federación Española de Municipios y Provincias (FEMP y Diputaciones Provinciales, dando lugar a la creación de una red de ciudades y pueblos sostenibles con unas características propias y con un crecimiento extraordinario que la ha situado como uno de los proyectos más importantes en materia de desarrollo sostenible a nivel regional y una experiencia pionera a nivel nacional.

Resultados de un sistema para la vigilancia de caries de la infancia temprana

OpenAIRE

Eduardo BERNABÉ ORTIZ; Elsa Karina DELGADO-ANGULO; Pablo César SÁNCHEZ-BORJAS

2006-01-01

Objetivo: Describir los resultados de un sistema, implementado con los estudiantes de la Facultad de Estomatología Roberto Beltrán Neira, para la vigilancia de caries de la infancia temprana (CIT) en niños entre 6 y 36 meses de edad de comunidades urbano-marginales de Sol Naciente de Carabayllo. Materiales y métodos: Sesenta y dos de los 97 niños que aceptaron participar en la evaluación inicial durante el semestre 2004-I, fueron reexaminados a los 12 (semestre 2005-I) y 18 meses (semestre 20...

Elastic Properties of the Solid Electrolyte Li₇La₃Zr₂O₁₂ (LLZO)

DEFF Research Database (Denmark)

Yu, Seungho; Schmidt, Robert D.; Garcia-Mendez, Regina

2016-01-01

The oxide known as LLZO, with nominal composition Li7La3Zr2O12, is a promising solid electrolyte for Li-based batteries due to its high Li ion conductivity and chemical stability with respect to lithium. Solid electrolytes may also enable the use of metallic Li anodes by serving as a physical bar...

Ejercicios técnico-tácticos para la ejecución de los pases con el empeine exterior del pie en futbolistas de la categoría 12-13 años / Technical-tactical exercises for the execution of the passes with the outer instep of the foot in soccer players of the category 12-13 years

Directory of Open Access Journals (Sweden)

Dayron Alberto Rice-Nelson

2016-08-01

Full Text Available Resumen El proceso de preparación técnico-táctica ofensiva en el fútbol constituye un pilar fundamental para lograr un buen desarrollo del juego y también alcanzar resultados favorables cuando se compite. Se pudo comprobar mediante un diagnóstico que los futbolistas de la categoría 12-13 años del Combinado Deportivo Previsora, municipio Camagüey, presentan insuficiencias en la ejecución de los pases con el empeine exterior del pie mientras compiten o entrenan, lo que afecta sus resultados; por tanto, esta investigación tiene como objetivo diseñar juegos y ejercicios que favorezcan la ejecución técnico-táctica de los pases con el empeine exterior del pie. Para ello se emplearon diversos métodos y técnicas como la entrevista, la revisión documental, la observación a sesiones de entrenamientos y la observación a competencias. Estos arrojaron como resultados que la ofensiva era poco variable, poco sorpresiva, con una constante pérdida de balones en su desarrollo. La elaboración del conjunto de juegos y ejercicios favorece la correcta ejecución técnico-táctica de los pases con el empeine exterior del pie y eleva el nivel de preparación deportiva. Abstract The process of technical-tactical preparation offensive in football is a fundamental pillar to achieve a good development of the game and also achieve a favorable outcome when competing. It was possible to verify by means of a diagnosis that the soccer players of the category 12-13 years of Combined Sport Previsora, municipality Camagüey, present insufficiencies in the execution of the passes with the outside instep of the foot while competing or training, which affects the results of its Football activity. Therefore, the present research aimed to design a set of games and exercises that favor the technical-tactical execution of the passes with the outer instep of the foot. For this, various methods and techniques were used, such as interviewing, document review, observing

La estatización bancaria en México: Una interpretación desde la perspectiva del pensamiento económico

Directory of Open Access Journals (Sweden)

Eduardo Turrent Díaz

2011-12-01

Full Text Available A 25 años de distancia, no contamos con una explicación convincente de por qué tuvo lugar la expropiación bancaria de 1982. En este trabajo se argumenta que el hecho tuvo su origen en posturas de pensamiento heterodoxas de las cuales derivó una propuesta de política económica alternativa a la que se había aplicado de 1958 a 1970. En general, la nueva propuesta de política económica contenía contradicciones que desembocaron en una crisis cambiaria de gran intensidad. En lo específico, el expansionismo fiscal y monetario implícito en esa política era incompatible con el mantenimiento de la estabilidad cambiaria. En congruencia con las posturas de pensamiento subyacentes en la política económica alternativa que se adoptó, la solución sugerida al presidente López Portillo por sus asesores económicos "reformistas" fue expropiar la banca y aplicar un control integral de cambios.25 years have passed since expropriation of private banks was decreed in Mexico in 1982. Since then, no convincing explanations of that decision have been presented. In this paper it is argued that the origins derived from heterodox currents of thought based on which an alternative economic policy was adopted, different to the one applied from 1958 to 1970. In general terms, that alternative economic policy implied strong contradictions, and its application derived in an intense devaluation crisis. Specifically, the fiscal and monetary expansionism implicit in the economic policy adopted, was incompatible with the maintenance of exchange stability. Based also on those heterodox currents of thought, the solutions suggested by his "Reformist" economic advisors to the president Lopez Portillo were to expropriate the private banks and apply a general exchange control.

Aplicación de la prueba de Gant en la predicción de la enfermedad hipertensiva gestacional

Directory of Open Access Journals (Sweden)

Berta de la C Moya Romero

1996-06-01

Full Text Available Se realizó un estudio en el Grupo Básico de Trabajo No. 3 del Policlínico Comunitario Docente "Jorge Ruiz Ramírez", del municipio Playa, a todas las embarazadas atendidas allí en el período comprendido entre el 1ro de enero de 1992 al 31 de diciembre de 1993 (ambos inclusive y que su parto ocurrió en los hospitales ginecoobstétricos de nuestra área de atención, "Eusebio Hernández" y "Clodomira Acosta"; se analizó la atención brindada a ellas hasta la terminación del embarazo. Se entrenó a todos los médicos para la realización de la prueba de Gant y se investigaron conjuntamente los siguientes parámetros: edad, peso de la gestante previo al embarazo, ganancia total de peso, paridad y los resultados obtenidos al realizar la prueba. Se concluye que la hipertensión inducida por el embarazo es frecuente en las edades extremas, que el sobrepeso antes del embarazo y la ganancia global mayor de 12 kg fueron factores predisponentes de importancia en la aparición de la enfermedad, y que la prueba de Gant es de gran efectividad en la predicción de esta afección.The Basic Working Group No. 3 from the "Jorge Ruiz Ramírez" Community Teaching Polyclinic, Playa municipality, conducted an study of all pregnant women treated there between January 1st, 1992 and December 31st, 1993 (even both, and who delivered at the "Eusebio Hernández" and "Clodomira Acosta" gynecoobstetric hospitals within our health area. Medical attention given to them until the end of pregnancy was analyzed. All physicians were trained to perform the Gant's test and the following parameters were investigated: age, body weight of expectant before pregnancy, total weight gain, parity, and the results obtained with the test. It is concluded that hypertension induced by pregnancy is common at extreme ages, that over weight before pregnancy and the global gain over 12 kg were important predisposing factors for the appereance of the disease, and that the Gant's test is

Un congreso de fisica estudia la composicion de las capas de la tierra

CERN Multimedia

2003-01-01

"El Congreso de Internacional de Neutrinos, que ayer comenzo en el Jardin Botanico de Valencia, aborda, entre otros aspectos, la composicion y el perfil tomografico de las distintas capas de estratos del interior de la Tierra, segun informo a Efe el profesor Jose Furtado Valle" (1/2 page).

Entre las novelas y las series: la recepción de la TV, hoy

Directory of Open Access Journals (Sweden)

Paulo Negri

2016-12-01

Full Text Available El Dr. Guillermo Orozco Gómez nació en 1954 en Guadalajara, México. Es licenciado en Ciencias de la Comunicación, por la Universidad Jesuita de Guadalajara (Iteso. Su doctorado fue en Educación, por la Universidad de Harvard. Sus líneas de investigación se han centrado principalmente en estudiar el impacto de la televisión en la formación de audiencias en América Latina.DOI: http://dx.doi.org/10.21882/ruc.v4i7.661 Recebido: 06/11/2016 Publicado: 07/12/2016 

LA FUNCIÓN VESTIBULAR Y SU CONCORDANCIA FRENOLÓGICA: CONECTANDO LA HISTORIA DE LA FUNCIÓN CEREBRAL VESTIBULAR

Directory of Open Access Journals (Sweden)

Jorge Eduardo Duque Parra

2012-09-01

Full Text Available En el presente trabajo se inter-relacionan eventos históricos y contemporáneos, que han permitido desde la intuición de los primeros frenólogos y posteriormente con aspectos clínicos y experimentales, determinar un acercamiento a la localización funcional cerebral del procesamiento de información vestibular, asociada con los movimientos de la cabeza. El objetivo es aclarar si se puede establecer un vínculo entre la información frenológica del siglo XVIII con el procesamiento funcional cortical vestibular, con base en investigaciones contemporáneas. Metodológicamente se compara la información vestibular que surgió de la frenología, con los datos contemporáneos de funcionales cerebrales. Se encontró que el sentido de la orientación espacial se postuló en la región craneal parietal de forma intuitiva por los pioneros de la Frenología, en coincidencia con el sabido procesamiento cerebral parietal para la aceleración angular y linear del movimiento de la cabeza. Se concluye que la asignación de la región frenológica 12 en la zona parietal craneal, es concordante, si se extrapola al lobo parietal, para el sentido del lugar y el sentido espacial, pues varios trabajos indican la asignación como zona cortical vestibular principal, a la que se encuentra en dicha región cerebral.

ESTUDIO DEL EFECTO DE LA ISOTERMA EN EL PROCESO DE SÍNTESIS DEL COMPUESTO DE ESTRONCIO Sr4Al6O12SO4 POR REACCIÓN EN ESTADO SÓLIDO

Directory of Open Access Journals (Sweden)

José Rodríguez-García

2012-01-01

Full Text Available Se estudió el efecto de la isoterma en la síntesis del compuesto de estroncio Sr 4 Al 6 O 12 SO 4 por reacción en estado sólido. Se conformaron (100MPa gránulos a partir de la mezcla 3:3:1 molar de SrCO 3 , Al 2 O 3 y SrSO 4 , respectivamente. Las muestras fueron tratadas térmicamente a temperaturas de 800, 900, 1000, 1100 y 1200°C por periodos de 4, 6, 8 y 10 horas. Las muestras, en presentación de polvo y pastilla, fueron analizadas por ATG, ATD, DRX y MEB, desde temperatura ambiente ha sta los 1200°C. Los resultad os de análisis térmico señalan que el rango de formación del compuesto de estroncio Sr 4 Al 6 O 12 SO 4 es entre los 800 y 1200°C. Por otro lado, de acuerdo a los patrones de difr acción de rayos X, la formación del mismo se favorece al incrementarse la isoterma del tratamiento térmico. Existen dos fases meta-estables presentes durante el proceso antes mencionado, las mismas que son observadas en el MEB.

Cellulose Derivatives Enhanced Stability of Alginate-Based Beads Loaded with Lactobacillus plantarum LAB12 against Low pH, High Temperature and Prolonged Storage.

Science.gov (United States)

Fareez, Ismail M; Lim, Siong Meng; Zulkefli, Nurul Aida Ashyqin; Mishra, Rakesh K; Ramasamy, Kalavathy

2017-05-10

The susceptibility of probiotics to low pH and high temperature has limited their use as nutraceuticals. In this study, enhanced protection of probiotics via microencapsulation was achieved. Lactobacillus plantarum LAB12 were immobilised within polymeric matrix comprised of alginate (Alg) with supplementation of cellulose derivatives (methylcellulose (MC), sodium carboxymethyl cellulose (NaCMC) or hydroxypropyl methylcellulose (HPMC)). L. plantarum LAB12 encapsulated in Alg-HPMC(1.0) and Alg-MC(1.0) elicited improved survivability (91%) in simulated gastric conditions and facilitated maximal release (∼100%) in simulated intestinal condition. Alg-HPMC(1.0) and Alg-MC(1.0) significantly reduced (P 7 log CFU g -1 . Alg-MC and Alg-HPMC improved the survival of LAB12 against simulated gastric condition (9.24 and 9.55 log CFU g -1 , respectively), temperature up to 90 °C (9.54 and 9.86 log CFU g -1 , respectively) and 4-week of storage at 4 °C (8.61 and 9.23 log CFU g -1 , respectively) with sustained release of probiotic in intestinal condition (>9 log CFU g -1 ). These findings strongly suggest the potential of cellulose derivatives supplemented Alg bead as protective micro-transport for probiotic strains. They can be safely incorporated into new functional food or nutraceutical products.

Propuesta de un conjunto de Actividades Recreativas para la ocupación del tiempo libre en los adolescentes en la edad comprendida de 12 a 15 años de la Circunscripción 18. Consejo Popular Carlos Manuel de Céspedes” del municipio Pinar del Río

Directory of Open Access Journals (Sweden)

Elisa Isabel Vázquez Molina

2009-12-01

Full Text Available Nuestro trabajo se realizó con el fin de desarrollar actividades que estuvieran en correspondencia con las características de la población seleccionada, en los adolescentes en edad comprendida de 12 a 15 años de la ESBU Julio A. Mella del Consejo Popular Carlos Manuel de Céspedes del municipio de Pinar del Río La necesidad de proporcionar una generación saludable, físicamente, multilateral y armónicamente desarrollada resulta cada vez más una exigencia de nuestra sociedad. Cada día la Cultura Física y sus distintas salidas como la Educación Física, Deporte y Recreación se convierten en una necesidad de cada individuo y de toda humanidad. Con independencia a estos logros es evidente que las actividades de la Recreación Física de una planificación que responda a los intereses recreativos implican una forma de recreación activo, que tiene como finalidad el desarrollo multifacético de los niños, jóvenes y adultos Es evidente que muchas de las actividades recreativas que realizan, son los jóvenes los que las llevan a cabo, aunque existen irregularidades que limitan las opciones que se brindan para el disfrute de la juventud, la realidad exige que existía una buena planificación partiendo de las posibilidades reales para el desarrollo óptimo de sus programas recreativos, de ahí que las bases del desarrollo social estén encaminados a satisfacer las necesidades cada vez más crecientes de la población. La planificación y programación de estas actividades dependen en gran medida de aspectos tan importantes como: la edad de los participantes, los gustos e intereses, así como la cultura requerida para su realización. La programación y oferta de las actividades recreativas debe ser de la preferencia de la sociedad a fin de que responda a los intereses comunes individuales, lo cual tributa a la conservación del carácter motivacional y recreativo de las actividades estando en correspondencia con la zona de residencia

Correlación de la t(9;22, t(12;21 e hiperdiploidía de ADN con el inmunofenotipo y la tasa de proliferación de células B neoplásicas en niños con leucemia linfoblástica aguda de precursores B

Directory of Open Access Journals (Sweden)

Sandra Milena Quijano

2013-09-01

Full Text Available Introducción. Del 60 al 80 % de los pacientes con leucemia linfoblástica aguda de precursores B presentan alteraciones genéticas que influyen en el pronóstico de la enfermedad y en la biología del tumor. Objetivo. Analizar distintas alteraciones genéticas en leucemia linfoblástica aguda de precursores B en niños, y su relación con el inmunofenotipo y con la tasa de proliferación, en comparación con precursores B normales. Materiales y métodos. En 44 pacientes se evaluó, por citometría de flujo, el inmunofenotipo, el contenido de ADN y la proliferación, y por RT-PCR, las traslocaciones t(9;22, t(12;21, t(4;11 y t(1;19. Mediante un análisis jerarquizado de conglomerados se identificaron los patrones inmunofenotípicosde expresión asociados a las traslocaciones, tomando como referencia precursores B normales. Resultados. La cuantificación del ADN mostró que el 21 % de los casos de leucemia linfoblástica aguda de precursores B eran hiperdiploides de índice alto y, el 47,7 %, hiperdiploides de índice bajo. La presencia de hiperdiploidía se asoció con mayor proliferación tumoral y con inmunofenotipos aberrantes, que incluyeron expresión anormal de CD10, TdT, CD38 y CD45 y un mayor tamaño de los linfoblastos. La presencia de t(9;22 y t(12;21 discrimina células normales de células tumorales con aberraciones en la expresión de CD19, CD20, CD13, CD33, CD38, CD34 y CD45. Conclusiones. El perfil de aberraciones fenotípicas detectado en conjunto con anormalidades en la proliferación tumoral, se asocia de forma significativa con hiperdiploidiía de ADN y discrimina deforma clara linfoblastos con t(9;22 y t(12;21 de los precursores B normales. La identificación de estos parámetros será de gran utilidad como herramienta para la clasificación y seguimiento de lospacientes.   doi: http://dx.doi.org/10.7705/biomedica.v33i3.1441

A Study of the Radioprotective Activity of the Imidazole Nucleus and Some of Its Derivatives; Etude de l'activite radioprotectrice du noyau imidazole et de quelquesuns de ses derives

Energy Technology Data Exchange (ETDEWEB)

Rinaldi, R; Bernard, Y [Commissariat a l' Energie Atomique. Centre d' Etudes Nucleaires, 38 - Grenoble (France)

1962-07-01

A study was made of the radioprotective properties of 8 compounds derived from imidazole. The effectiveness of the compounds was tested in mice exposed to a lethal dose of x radiation. Results showed that imidazole afforded protection to about 85% of the animals. Little protection was afforded by imidazoline and thione-imidazoline compounds in spite of the existence of a free sulfhydryl group in these compounds. (authors) [French] Cette etude a ete consacree a la determination des proprietes radioprotectrices eventuelles de huit composes derives de l'imidazole. Ces substances ont ete, soit synthetisees, soit obtenues dans le commerce. Leur efficacite a ete mise en evidence par le pourcentage de survie obtenu chez des souris soumises a une dose mortelle de rayons X. Les resultats ont fait apparaitre: - l'activite remarquable de l'imidazole qui protege environ 85 pour cent des animaux; - la protection faible ou nulle obtenue avec les imidazolinones et les thione-imidazolines, malgre la presence dans la molecule de ces dernieres d'un groupement sulfhydrile libre. (auteurs)

LA PARIDAD DE PODER DE COMPRAEN MÉXICO (1930-1960

Directory of Open Access Journals (Sweden)

Frederick H. Wallace

2011-01-01

Full Text Available Empleamos una serie de datos no explotados anteriormente para calcular el tipo de cambio real respecto al dólar para México durante 1930.01-1960.12 a fin de probar la paridad de poder de compra (PPC. Los resultados iniciales de la prueba de Dickey-Fuller aumentada (DFA muestran un débil apoyo para la PPC. La prueba de Kapetanios, Shin, and Snell (KSS, con otra hipótesis de reversión no lineal a la media, muestra bastante apoyo para la PPC. Sin embargo, encontramos que los residuos de estas pruebas presentan no normalidad o heteroscedasticidad. Usando el enfoque de wild bootstrap, calculamos los valores críticos de la distribución empírica de los residuos y reevaluamos los estadísticos de prueba empleando estos nuevos valores críticos. Concluimos que hay evidencia de ajuste no lineal a la PPC para 1930.01-1951.12, pero esta evidencia no se mantiene durante 1952.01-1960.12, el periodo de sustitución de importaciones en México.

El cuerpo entre la educación, la política y los estudios sociales.

Directory of Open Access Journals (Sweden)

Javier Schargorodsky

2016-09-01

Full Text Available P { margin-bottom: 0.21cm; direction: ltr; color: rgb(0, 0, 0; text-align: left; }P.western { font-family: "Liberation Serif",serif; font-size: 12pt; }P.cjk { font-family: "Tahoma (Thai"; font-size: 12pt; }P.ctl { font-family: "Times New Roman CE"; font-size: 12pt; } En el libro Cuerpo, educación, política: tensiones epistémicas, históricas y prácticas, Eduardo Galak y Emiliano Gambarotta compilan ocho artículos en los cuales, desde diversos enfoques, se realizan aportes a las investigaciones sociales sobre el cuerpo. La compilación está estructurada en tres partes. La primera, titulada “Tensiones epistemológicas: la conquista del problema”, está compuesta por tres capítulos que brindan herramientas para la construcción del objeto de estudio en cuestión, objeto que oscila entre el cuerpo y las prácticas corporales. La segunda parte se titula “Tensiones histórico-genealógicas en la educación de los cuerpos”. Allí se inscriben dos textos en los que se muestran las consonancias y disonancias entre las políticas educativas del distrito bonaerense y las políticas nacionales. La tercera parte del libro “Tensiones de las prácticas corporales: deportes, juegos, danzas”, se centra en prácticas corporales específicas. Los autores de los capítulos son: Ricardo Crisorio, Emiliano Gambarotta, Santiago Pich, Sidinei Pithan da Silva, Paulo Fensterseifer, Myriam Southwell, Eduardo Galak, Alexandre Fernández Vaz, Carolina Duek, Noelia Enriz y Ana Sabrina Mora.

Uso e influencia de la televisión en la infancia

OpenAIRE

Arroyo Jiménez, Isabel

2012-01-01

Esta investigación está contextualizada en torno al uso e influencia que ejerce la televisión en la infancia. En concreto hemos escogido un grupo de niños del tercer ciclo de Educación Primaria (10-12 años). Primeramente, tratamos de comprobar el uso que hacen de la televisión los alumnos que hemos tomado como muestra así como el tipo de programas que ven. Posteriormente, analizaremos una pequeña muestra de esos programas más seguidos por nuestros alumnos encuestados. Para ello, partire...

Competitive accumulation of betaines by Escherichia coli K-12 and derivative strains lacking betaine porters.

Science.gov (United States)

Randall, K; Lever, M; Peddie, B A; Chambers, S T

1995-08-17

Escherichia coli was grown in hyperosmotic media containing both glycine betaine and one other betaine. E. coli K-12 derivative WG439 (putP- proP- proU-) did not accumulate any of 15 betaines. Strains WG445 (putP- proP- proU+), WG443 (putP- proP+ proU-) and the control strains all accumulated less betaine, (CH3)3N(+)-(CH2)n-COO-, when n was greater than 1. Accumulation was not detectable when n = 5. Both L- and D-isomers of alpha-substituted betaines were accumulated by both strains WG443 and WG445, the D-isomers more slowly. Hydroxylated alpha-substituted betaines were accumulated relatively more through the osmoregulated transport protein ProU than through ProP. In actively growing cultures glycine betaine appeared to be the preferred substrate for accumulation, but the proportion of the second accumulated betaine increased as cultures approached stationary phase.

Tesis sobre hegel y la revolución

OpenAIRE

Korsch, Karl

2011-01-01

I. No puede comprenderse la filosofía hegeliana y su método dialectico más que en su conexión con la revolución.1. Ella derivó históricamente del movimiento histórico de suépoca.2. Cumplió la tarea de traducir en el pensamiento el movimiento revolucionario de su tiempo.3. .El pensamiento dialectico es revolucionario también en cuanto a la forma:a) Separación de los datos inmediatos, ruptura radical con lo que existe, inversión, nuevo comienzo;b) Principio de la oposición y de la negación;c) P...

La vocación en los evangelios

OpenAIRE

Morales, J. (José)

2002-01-01

 1. LOS PRIMEROS DISCÍPULOS DE JESÚS. 2. LLAMADA DIRECTA. 3. LLAMADA PERSONAL. 4. UNA INVITACIÓN IMPREVISIBLE. 5. LA EFICACIA DE LA LLAMADA. 6. EL NÚCLEO DE LOS DISCÍPULOS: LOS DOCE. 7. LA LLAMADA PARA EL SERVICIO DEL REINO. 8. LLAMADA DE JESÚS Y ELECCIÓN DIVINA. 9. LA URGENCIA DE LA ACEPTACIÓN. 10. SEGUIMIENTO SIN CONDICIONES. 11. SEGURIDAD Y RIESGO. 12. LA VOCACIÓN COMO GRACIA. 13. ELEGIDOS EN EL HIJO.

Relación entre el receptor de la favina y la galactosil uridil transferasa de la membrana de eritrocitos

Directory of Open Access Journals (Sweden)

María Inés Silva

2010-07-01

Full Text Available La extracción y purificación de un receptor de la favina fue realizada a partir de la membrana de eritrocitos, empleando para ello básicamente la cromatografía de intercambio iónico sobre DEAE-celulosa con miras a establecer su relación con la actividad de la Galactosa 1-fosfato Uridil Transferasa (EC 2.7.7.12, OUT. Se obtuvo una proteína con un alto grado de pureza (determinada por electroforesis sobre poliacrilamida en ausencia y presencia de SDS que presenta un peso molecular de 58.000 daltons y otra fracción que también interacttía con la favina y que contiene por lo menos seis proteínas de pesos moleculares entre 23.000 y 71.000 daltons. La fracción cromatográfica que contiene la proteína de 58.000 daltons presenta actividad de OUT, sin embargo esta actividad es inestable y se pierde después de mantener la muestra a 4'C durante 24 horas. De acuerdo a nuestros resultados, la dos actividades (receptor y actividad enzimática no interfieren entre si a pesar de encontrarse sobre la misma fracción proteica.

Evaluación de la supervivencia y del crecimiento en la reforestación del proyecto piloto de Albatera tras 12 años

Directory of Open Access Journals (Sweden)

John Molina

2016-11-01

Full Text Available El presente trabajo consiste en el seguimiento y evaluación de los resultados de la restauración forestal ecológica realizada en la cuenca de Albatera durante los años 2003 y 2004, poniendo énfasis en la supervivencia después del verano de 2014 comparada con la supervivencia registrada en los años anteriores. Para la toma de los datos ha sido necesario desplazarse a la cuenca durante 20 días entre los meses de febrero y marzo del 2015 para recoger datos de supervivencia y tamaño de las diez especies estudiadas: tres especies arbóreas (Pinus halepensis, Tetraclinis articulata, Ceratonia siliqua y siete arbustivas (Pistacia lentiscus, Quercus coccifera, Rhamnus lycioides, Ephedra fragilis, Chamaerops humilis, Juniperus oxycedrus y Olea europea ssp sylvestris. Además fue necesario realizar otras tareas como la revisión de los datos históricos de las repoblaciones realizadas como del clima de la zona. Los resultados muestran mayor supervivencia y crecimiento de los plantones plantados en la solana sobre los de umbría, y sobre todo sobre los ubicados en la unidad de terrazas forestales. Además se encontró una mayor supervivencia de los especímenes plantados en la campaña del año 2004 respecto a los introducidos en la campaña del 2003.

Un acercamiento a la perspectiva sobre la vida sexual de adolescentes de un establecimiento educativo en zona norte en la ciudad de Salta

OpenAIRE

Soler, Ana Lucia

2011-01-01

p. 105-116 Planteo y conclusiones iniciales de proyecto de investigación sobre la sexualidad en adolescentes de 12 a 16 años. Se busca conocer la forma de presentación de la vida sexual, construir significaciones y ubicar las consecuencias subjetivas de las perspectivas adolescentes. Se incluyen en el análisis la perspectiva vincular, identificatoria y de satisfacción pulsional. Se trabajó con metodología e instrumentos cuanti y cualitativos. El marco teórico responde al psicoanálisis de l...

Análisis de la influencia de las Tecnologías de la Información y la Comunicación (TIC) en la productividad de capital : un estudio en el sector hotelero español

OpenAIRE

García Saiz, Francisco

2013-01-01

1.2. OBJETIVOS DEL PROYECTO. El propósito de éste estudio es conocer la influencia que tienen las Tecnologías de la Información y la Comunicación (TIC) sobre la productividad de las empresas del sector hotelero en España. Para ello se diseñarán varios indicadores en distintos niveles, con los que mediremos cuales de ellas son más significativas para mejorar la productividad del capital (CP) en las empresas hoteleras del sector. Para ello, se ha trabajado sobre los siguien...

10-oxo-12(Z)-octadecenoic acid, a linoleic acid metabolite produced by gut lactic acid bacteria, potently activates PPARγ and stimulates adipogenesis.

Science.gov (United States)

Goto, Tsuyoshi; Kim, Young-Il; Furuzono, Tomoya; Takahashi, Nobuyuki; Yamakuni, Kanae; Yang, Ha-Eun; Li, Yongjia; Ohue, Ryuji; Nomura, Wataru; Sugawara, Tatsuya; Yu, Rina; Kitamura, Nahoko; Park, Si-Bum; Kishino, Shigenobu; Ogawa, Jun; Kawada, Teruo

2015-04-17

Our previous study has shown that gut lactic acid bacteria generate various kinds of fatty acids from polyunsaturated fatty acids such as linoleic acid (LA). In this study, we investigated the effects of LA and LA-derived fatty acids on the activation of peroxisome proliferator-activated receptors (PPARs) which regulate whole-body energy metabolism. None of the fatty acids activated PPARδ, whereas almost all activated PPARα in luciferase assays. Two fatty acids potently activated PPARγ, a master regulator of adipocyte differentiation, with 10-oxo-12(Z)-octadecenoic acid (KetoA) having the most potency. In 3T3-L1 cells, KetoA induced adipocyte differentiation via the activation of PPARγ, and increased adiponectin production and insulin-stimulated glucose uptake. These findings suggest that fatty acids, including KetoA, generated in gut by lactic acid bacteria may be involved in the regulation of host energy metabolism. Copyright © 2015 Elsevier Inc. All rights reserved.

Vitamin B12-Containing Plant Food Sources for Vegetarians

Science.gov (United States)

Watanabe, Fumio; Yabuta, Yukinori; Bito, Tomohiro; Teng, Fei

2014-01-01

The usual dietary sources of Vitamin B12 are animal-derived foods, although a few plant-based foods contain substantial amounts of Vitamin B12. To prevent Vitamin B12 deficiency in high-risk populations such as vegetarians, it is necessary to identify plant-derived foods that contain high levels of Vitamin B12. A survey of naturally occurring plant-derived food sources with high Vitamin B12 contents suggested that dried purple laver (nori) is the most suitable Vitamin B12 source presently available for vegetarians. Furthermore, dried purple laver also contains high levels of other nutrients that are lacking in vegetarian diets, such as iron and n-3 polyunsaturated fatty acids. Dried purple laver is a natural plant product and it is suitable for most people in various vegetarian groups. PMID:24803097

Vitamin B12-Containing Plant Food Sources for Vegetarians

Directory of Open Access Journals (Sweden)

Fumio Watanabe

2014-05-01

Full Text Available The usual dietary sources of Vitamin B12 are animal-derived foods, although a few plant-based foods contain substantial amounts of Vitamin B12. To prevent Vitamin B12 deficiency in high-risk populations such as vegetarians, it is necessary to identify plant-derived foods that contain high levels of Vitamin B12. A survey of naturally occurring plant-derived food sources with high Vitamin B12 contents suggested that dried purple laver (nori is the most suitable Vitamin B12 source presently available for vegetarians. Furthermore, dried purple laver also contains high levels of other nutrients that are lacking in vegetarian diets, such as iron and n-3 polyunsaturated fatty acids. Dried purple laver is a natural plant product and it is suitable for most people in various vegetarian groups.

Fracturas por estrés en deportistas: Valor de la resonancia magnética en la predicción de la morbilidad Stress fractures in athletes: Role of magnetic resonance imaging in predicting injury morbidity

Directory of Open Access Journals (Sweden)

Javier Maquirriain

2007-06-01

Full Text Available La resonancia magnética ha mostrado ser una herramienta eficaz para el diagnóstico precoz de las fracturas por estrés y para la determinación de la gravedad de estas lesiones. El objetivo de este estudio fue determinar la relación entre la gravedad de las fracturas por estrés en deportistas, determinada por resonancia magnética y la morbilidad, estimada por el tiempo de retorno al deporte. Se estudiaron 34 casos de fracturas por estrés, correspondientes a 29 deportistas (12 mujeres; 17 varones; edad 26.3 ± 12.5 años, mediante radiografías y resonancia magnética. Las lesiones fueron clasificadas en cuatro grados según la escala de Arendt. Se determinaron la localización anatómica, el nivel de actividad, el tiempo de diagnóstico y el tiempo de retorno a la actividad deportiva. Los huesos más afectados fueron la tibia (n=12; 35.2%, el escafoides tarsiano (n=5; 14.7% y los metatarsianos (n=4; 11.7. La gravedad de las lesiones fue: grado 1: 14.7%; grado 2: 14.7%; grado 3: 38.2%; grado 4: 32.4%. La correlación entre la gravedad de la lesión y el tiempo de recuperación fue de r=0.66 (p=0.0002. Como conclusión, existe una correlación positiva significativa entre la gravedad de la fractura por estrés, determinada por resonancia magnética, y el tiempo de recuperación. La utilización sistemática de esta clasificación puede ayudar a definir con mayor precisión el cuadro clínico, controlar la rehabilitación y estimar el retorno a la actividad deportiva.Magnetic resonance imaging is a useful tool for stress fractures (SF diagnosis, allowing the estimation of injury severity. The aim of this study was to determine the relation between the severity of SF in athletes determined by magnetic resonance imaging and the morbidity estimated as the time to return to sport. Thirty-four cases of stress fractures, (29 athletes; 12 female, 17 male; age 26.3 ± 12.5, were studied by radiographs and magnetic resonance imaging. Injuries were

EFECTO DE LA VEGETACIÓN EN LA INTERCEPCIÓN DE LA PRECIPITACIÓN EN LA PRECORDILLERA DE LA REGIÓN DEL MAULE, CHILE

Directory of Open Access Journals (Sweden)

O. S. Vallejos-Barra

2010-01-01

Full Text Available En este estudio se comparó el comportamiento de un bosque secundario de Roble-Hualo, donde las especies predominantes son Nothofagus obliqua y Nothofagus glauca y una plantación de Pinus radiata D. Don de 12 años de edad, en el proceso precipitación - intercepción. El estudio se desarrolló en la Estación Experimental El Picazo, comuna de San Clemente, Región del Maule, Chile, entre el mes de julio de 2007 a julio de 2008, en dos microcuencas vecinas de dimensiones reducidas con condiciones similares de suelo, exposición y pendiente pero que diferían en la cobertura vegetal. Se caracterizó la vegetación de cada microcuenca y se establecieron indicadores de densidad de parcela. Los indicadores de la cobertura nativa superaron ampliamente a los de las coberturas exóticas. Para registrar la precipitación se instalaron dos pluviógrafos del tipo Hobo en cada microcuenca. Equidistante de ellas se ubicó otro pluviógrafo sin cobertura vegetal. Se registraron 21 tormentas caracterizando temporal y espacialmente el comportamiento de la precipitación abierta y bajo dosel. Los resultados indican que pese a tener diferencias numéricas las coberturas vegetales, éstas no se transforman en diferencias estadísticamente significativas. Además se observó que la intercepción depende en mayor medida de la arquitectura de copa, distribución espacial de los árboles y tipo de hojas, que de la cantidad de árboles por parcela.

UNA APROXIMACIÓN A LA EVOLUCIÓN DE LOS IMPUESTOS Y LA CURVA DE LAFFER EN COLOMBIA (1990-2008

Directory of Open Access Journals (Sweden)

Jhoana Patricia Bolaños Muñoz

2010-01-01

Full Text Available Este artículo pretende aproximarse a la evolución de la estructura tributaria en Colombia, y la aplicación de la teoría económica concerniente a la curva de Laffer durante los últimos diecinueve años. En Colombia se han realizado aproximadamente dos reformas tributarias por cada periodo presidencial, cada una de estas reformas ha traído consigo incrementos en las tarifas y bases tributarias, sobre todo por la vía indirecta. Buena parte de la carga impositiva indirecta que hoy tiene el país, se derivó de la apertura comercial y los cambios constitucionales de 1990. El análisis gráfico mostró que excesivos incrementos tributarios han llevado en el mediano plazo a que caigan los ingresos tributarios del Estado en lugar de acrecentarse potencialmente.

Synthesis of quinoxaline derivatives via condensation of aryl-1,2-diamines with 1,2-diketones using (NH4)6 Mo7 O24 . 4 H2 O as an efficient, mild and reusable catalyst

International Nuclear Information System (INIS)

Hasaninejad, A.; Zare, A.; Mohammadizadeh, M. R.; Karami, Z.

2009-01-01

Ammonium heptamolybdate tetrahydrate [(NH 4 ) 6 Mo 7 O 24. 4H 2 O] efficiently catalyzes the condensation of aryl-1,2-diamines with l,2-diketones in EtOH/H 2 O as a green media at room temperature to afford quinoxaline derivatives as biologically interesting compounds. Ease of recycling of the catalyst is one of the most advantages of the proposed method

La caída de la motivación autodeterminada en jóvenes escolares

OpenAIRE

Cecchini Estrada, Jose Antonio; Fernández Losa, José Luis; González González de Mesa, Carmen; Fernández Río, Javier; Méndez Jiménez, Antonio

2012-01-01

El propósito de este estudio es analizar la progresiva desvinculación de los jóvenes escolares con la actividad físico-deportiva desde la Teoría de la Autodeterminación (Deci y Ryan, 1985, 1991). La muestra estuvo formada por 705 estudiantes, con edades comprendidas entre los 10 y los 14 años (329 de Educación Primaria, y 376 de Educación Secundaria, de una media de edad de 12.7 años). Se realizaron tres MANOVAs 2 (género) _ 2 (etapas educativas), que revelaron que los estudiantes de Ed...

Prevalence of anemia in children 1 to 12 years of age: results from a nationwide probabilistic survey in Mexico Prevalencia de anemia en niños de 1 a 12 años de edad: resultados de una encuesta probabilística nacional de México

Directory of Open Access Journals (Sweden)

Salvador Villalpando

2003-01-01

Full Text Available OBJECTIVE: To describe the epidemiology and analyze factors associated with iron deficiency anemia in a probabilistic sample of the Encuesta Nacional de Nutrición 1999 (ENN-99 [National Nutritional Survey 1999 (NNS-99]. MATERIAL AND METHODS: The sample included 8 111 children aged 1 to 12 years, and was nationaly representative by rural and urban strata and by four geographical regions. Capillary hemoglobin was measured using a portable photometer (HemoCue. The analysis of the determining factors of anemia was performed by odds ratios derived from a logistic regression model and multiple regression models. RESULTS: The prevalence of anemia was 50% in infants OBJETIVO: Describir la epidemiología y analizar los determinantes de la anemia en una muestra probabilística de la Encuesta Nacional de Nutrición 1999 (ENN-99. MATERIAL Y MÉTODOS: La muestra del estudio, hecho en 1999, incluyó 8 111 menores de entre 1 a 12 años de edad, representativa a escala nacional, de estratos rural y urbano y de cuatro regiones geográficas de México. La hemoglobina capilar fue medida mediante un fotómetro portátil (HemoCue. El análisis de los determinantes de anemia se hizo mediante razón de momios obtenidas con un modelo de regresión logística y modelos de regresión múltiple. RESULTADOS: La prevalencia de anemia fue más alta (50% en menores de dos años de edad, sin diferencias entre urbanos y rurales en las cuatro regiones geográficas. La prevalencia general de anemia varió entre 14 y 22% en niños y niñas de 6 a 12 años de edad, y fue más alta en la región sur y en los niños indígenas. La ingestión de hierro fue muy baja en menores de dos años de edad (50% de la ingesta diaria recomendada, pero no en los mayores; la ingestión de fitatos (»500-800 mg/d y taninos (»19 mg/d fue muy alta en niños >7 años de edad. El nivel de hemoglobina se asoció positivamente con el estado nutricio de los niños (p=0.01 y el nivel socioecon

Actividades Deportivo-Recreativas para la ocupación del tiempo libre de los adolescentes en edades entre 11 y 12 años de la Circunscripción # 39 del Consejo Popular Bahía Honda Este

Directory of Open Access Journals (Sweden)

Eddy Emigdio Rivera Solano

2010-09-01

Full Text Available Las comunidades como asentamientos de personas con variados hábitos y necesidades presentan características psíquico-cognoscitivas que son manifiestas en cada una de sus vivencias. El estudio sociológico de estas comunidades y dentro de ellos acerca del empleo del tiempo libre, determina en gran medida su crecimiento social y económico, lo que determinara también un crecimiento en los servicios, aspecto importante para alcanzar un nivel de aceptación en la calidad de vida de la población. Estos estudios se pueden considerar importante pues el buen empleo de tiempo libre influye en la formación de la personalidad del hombre lo cual se hace manifiesto en su modo de vida, de igual forma provoca cambios en sus hábitos, ideología y cultura social de cómo emplear su tiempo libre en actividades de su gusto y preferencia aspecto del cual carece la comunidad motivo de investigación, esto ha provocando manifestaciones negativas en el conducta de los adolescentes en lo individual y colectivo. Por esta razón, conociendo a través de la observación diaria la situación de esta comunidad y en especial de los adolescentes se realizó un diagnóstico de la situación concreta del lugar, el cual contempla un grupo de aspectos como: datos socio-demográficos y generales de la población objeto de estudio, ofertas recreativas, así como las necesidades e intereses de estos adolescentes, por lo que se hizo necesario implementar un grupo de acciones encaminadas a transformar aquellas conductas que son proclives para el buen desarrollo humano con actividades físico-recreativas para la ocupación del tiempo libre de los adolescentes entre las edades comprendidas 11-12 años de la circunscripción #39 Consejo Popular Bahía Honda Este.

Synthesis of new oxindole derivatives containing benzothiazole and thiazolidinone moieties using nano silica-bonded 5-n-propyl-octahydro-pyrimido[1,2-a]azepinium chloride (NSB-DBU) as catalyst

OpenAIRE

BAHARFAR, ROBABEH; SHARIATI, NARGES

2015-01-01

A facile one-pot synthesis of novel oxindole derivatives bearing benzothiazolylmethyl-2-thioxothiazolidin-4-one was accomplished via one-pot reaction of 5-oxoindolinylidene rhodanine-3-acetic acid derivatives, 2-aminothiophenol, and triphenyl phosphite in the presence of tetrabutylammonium bromide (TBAB) and nano silica-bonded 5-n-propyl-octahydro-pyrimido[1,2-a]azepinium chloride (NSB-DBU) as heterogeneous reusable nanocatalyst. The target compounds were obtained in excellent yields (...

Implicaciones sismotectónicas de las soluciones mecanismo focal de algunos terremotos de la región central de Colombia

Directory of Open Access Journals (Sweden)

Salcedo Hurtado Elkin de Jesús

2001-08-01

Full Text Available

12.0pt; font-family: ">Focal mechanism solutions of twenty recent earthquakes ocurred at different depthes and tectonics environment have been analysed toestablish the seismotectonic framework of the central region of Colombian territory. 12.0pt; font-family: " lang="FR">The intermediate earthquakes in the western part of theregion, in the majority respond to traction force and correspond to the subduction phenomenon of the oceanic lithospheric material beneathcontinental plate. While the superficial events ocurred at the continent crustal in the majority being of compressional type are related with the activity of different faults that cross the region. This activity is derived from the collision of the Nazca plate with the Andean Block. On the East Andean frontal fault system is noted a continuation of the tectonic stresses at the interior of the crustal to the earth's surface. In general, the geodymanic regimen of the nothwestern corner of the South American continent is governed by the collision of three major tectonic plates, that cause the deformation and displacement of the Andean Block in NNE direction.

12.0pt; font-family: ">Se han analizado las soluciones del mecanismo focal de veinte terremotos ocurridos a diferentes profundidades y ambientes tectónicos para establecer el marco sismotectónico de la región central del territorio colombiano. Los sismos intermedios ocurridos en la parte occidental de la región, en su mayoría responden a fuerza de tracción y corresponden a la subducción del material litosférico de la placa oceánica bajo la placa continental, mientras que los eventos superficiales que tienen lugar en el continente en su mayoría son de tipo compresivo y están relacionados con la actividad de las diferentes fallas que atraviesan la

La maitrise d'oeuvre d’execution et la direction du projet d’extension de l’hôtel Shangri-La Paris

OpenAIRE

Mestre Galofre, Arquímedes

2011-01-01

Ce rapport a pour intérêt d’expliquer et refléter le déroulement de la mission du stage abordé pendant les 6 mois dans l’entreprise Mercure Engineering & Consulting. Cette mission commence dans les bureaux de Mercure dédiés au projet de SLPR installés au pied du chantier au numéro 12 de la rue Fresnel. Le projet consiste en l’agrandissement de l’emblématique Hôtel Shangri-La Paris dans le 16ème arrondissement, situé dans le quartier privilégié du Trocadéro, avec vues spectaculaires sur la ...

La desigualdad social bajo la prueba Enlace

Directory of Open Access Journals (Sweden)

Ana Karina Bautista Gomez

2012-01-01

Full Text Available Tratar el tema de la educación desde la perspectiva de la pobreza obliga a plantear diversas cuestiones, entre las cuales Bracho (1995 destaca la manera en que se relacionan ambos fenómenos, si se relacionan, y si pueden o no ser problemas de política pública. Esta tendencia a vincular la educación con la pobreza no es exclusiva de una corriente analítica o de una zona específica, es más bien comprensible desde el contexto socioeconómico en el que se presenta dicha relación. Es sorprendente, por ejemplo, que un país con grandes recursos y oportunidades como México tenga un promedio de escolaridad, en 2011, de 8.6 años, por debajo de los 12 años que comprende la educación básica u obligatoria, y que más del 50% de la población total se encuentre en pobreza extrema. Partiendo de que la pobreza es la negación de las oportunidades y las opciones básicas para el desarrollo humano, así como la ausencia de determinadas capacidades elementales para realizarse, los individuos de hogares afectados por esta condición poseen menos oportunidades educativas que el resto de la población, debido en gran parte a factores como la lejanía respecto de los centros educativos, los altos costos de oportunidad, las bajas expectativas en el aprendizaje y el menor capital cultural con el que cuentan. Los hijos de los pobres desarrollan un capital inferior, tal atraso se reproduce una vez más en la siguiente generación, forjando una pobreza educativa intergeneracional. Del lado de la educación, las personas con más años de escolaridad tienen acceso a trabajos de alta productividad y mejores salarios, mientras que los individuos con baja escolaridad difícilmente logran obtener un mejor estatus social y salir de los círculos de la pobreza.

Prevalencia de caries dental en escolares de 6-12 años de edad de León, Nicaragua Prevalence of dental caries in 6-12-year-old schoolchildren in Leon, Nicaragua

Directory of Open Access Journals (Sweden)

Míriam del Socorro Herrera

2005-08-01

Full Text Available Objetivo: Determinar la prevalencia de caries dental, el índice de caries significativo (SiC y los índices ceod y CPOD (suma de dientes cariados, perdidos/extraídos y obturados en la dentición temporal y permanente en escolares de 6 a 12 años de edad de León, Nicaragua. Pacientes y método:Los datos dentales de una muestra representativa de 1.400 niños escolares fueron recogidos y analizados en un estudio transversal (año 2002. Todos los sujetos fueron examinados visual y clínicamente por uno de los 2 examinadores capacitados y estandarizados. Resultados: El 28,6% de los niños estaba libre de caries en ambas denticiones. La prevalencia de caries en la dentición temporal a los 6 años de edad fue del 72,6% y la de la dentición permanente a los 12 años fue del 45,0%. El SiC fue 4,12 en los niños de 12 años de edad. La media de los índices de caries (ceod y CPOD para la muestra fue 2,98 ± 2,93 (n = 1.125 y 0,65 ± 1,43 (n = 1.379. Los niños con antecedentes de caries en la dentición temporal tuvieron mayor probabilidad de presentar caries en la dentición permanente (odds ratio = 2,48; intervalo de confianza del 95%, 1,66-3,79. Conclusión: Se observó una baja prevalencia de caries en la dentición permanente con un alto porcentaje de dientes obturados, a diferencia de lo observado en la dentición temporal. A unos años de las metas propuestas para el año 2000 (FDI/OMS, no se cumplieron los objetivos en los niños de 6 años de edad. Sin embargo, la meta para el año 2000 en niños de 12 años fue satisfactoria. Como en otros estudios, observamos que la experiencia de caries en la dentición temporal se encuentra asociada con la presencia de caries en la dentición permanente.Objective: To determine the prevalence of caries, deft and DMFT indices (sum of decay, messing, and filling tooth in primary and permanent dentition, and the Significant Caries Index (SiC in scholars from Leon, Nicaragua. Patients and method: Dental data

Serie de ejercicios para la técnica recibo activo de derecha y remate de los atletas de Tenis de Mesa de la categoría 11-12 años del sexo femenino de la EIDE “Ormani Arenado” de Pinar del Río

Directory of Open Access Journals (Sweden)

Ayran Arencibia Moreno

2007-12-01

Full Text Available Con el presente trabajo se muestra una propuesta de una serie de ejercicios con situaciones reales de juego para las técnicas recibo activo de derecha y remate en los atletas de Tenis de Mesa del sexo femenino de la categoría 11-12 años de la EIDE Ormani Arenado de Pinar de Río para el mejoramiento en la enseñanza, iniciación y desarrollo de la modalidad deportiva en cuestión, con ellos se puede aprender y/o ejercitar los aspectos técnico-tácticos necesarios para esta categoría, permitiendo una practica más eficiente. Tomamos estas técnicas porque las mismas tienen gran importancia dentro del accionar táctico por su importancia en la definición de las acciones. Para ello se tuvo en cuenta a los 6 atletas de esta categoría. Proponiendo como objetivo una serie de ejercicios para facilitar la ejecución de las técnicas recibo activo de derecha y remate. Para ello empleamos métodos teóricos y empíricos. Dentro de los teóricos el histórico lógico, inductivo deductivo, análisis síntesis, dentro de los empíricos trabajo con documentos, entrevistas, observación, valoración con especialistas. Nuestra propuesta reviste vital importancia porque con ella se logra confeccionar una serie de ejercicios para dichas técnicas que no existían con anterioridad en ningún documento, convirtiéndose en un arma imprescindible para los profesores/entrenadores de Tenis de Mesa de nuestro país en el momento de desarrollar los diferentes componentes de la preparación Técnico-Táctica.

Contrôle de la température durant le processus de dégradation d'un acier Z12CNS20 en frottement avec un acier Z200C13

Science.gov (United States)

Khanafi-Benghalem, N.; Loucif, K.; Benghalem, K.; Boudoukha, H.; Louahdi, R.

2005-05-01

La température de contact lors des essais d'usure varie d'une manière spontanée et aléatoire. Cette température de contact dépend essentiellement de la nature du couple des matériaux en contact de la charge et de la vitesse. Cependant la mesure de la température est très difficile à effectuer compte tenu du choix de l'endroit de prise de la température et des phénomènes d'évacuation de la chaleur et de la dissipation de l'énergie. Dans ce travail nous exposons une méthode très simple de mesure de la température et nous étudions par conséquent la variation de la température du Z12CNS20 / Z200C13. Au cours des essais d'usure pour différentes vitesses de glissement, nous montrons en effet que la température augmente d'une manière progressive en fonction de la vitesse puis elle s'élève brutalement au fur et à mesure qu'on se rapproche du point de contact, et enfin nous prouvons par observation métallographique que l'échantillon subit un écoulement plastique provoqué par l'élévation de la température en fonction de la vitesse.

The education form the moral autonomy in the intercultural school La educación para la autonomía moral en la escuela intercultural

Directory of Open Access Journals (Sweden)

Eduardo S. Vila Merino

2012-07-01

-para-margin-bottom:10.0pt; mso-para-margin-left:0cm; line-height:115%; mso-pagination:widow-orphan; font-size:12.0pt; font-family:"Times New Roman"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin;} Esta artículo pretende ofrecer elementos para la reflexión en torno a la necesidad de la educación para la autonomía moral en la escuela y los principios pedagógicos susceptibles a tener en cuenta desde la perspectiva intercultural. Para ello se realiza un posicionamiento teórico y conceptual en torno a la educación para la autonomía moral y la ética como referente de la misma, para adentrarnos en la realidad de la escuela multicultural y el reto que implica esta educación para la autonomía moral en un contexto diverso culturalmente, lo cual supone uno de los grandes desafíos en el desarrollo de la educación intercultural en los centros educativos y un mecanismo para el desarrollo de competencias cívicas interculturales, así como para la prevención, gestión y resolución de los conflictos dentro de la comunidad educativa.

Calidad de vida relacionada con la salud en función de la categoría ponderal en la infancia Health-related quality of life across weight categories in childhood

Directory of Open Access Journals (Sweden)

José A. Piqueras

2012-04-01

Full Text Available Objetivos: Analizar las diferencias en calidad de vida relacionada con la salud en función de la categoría ponderal basada en el índice de masa corporal en niños y niñas de 8 a 12 años de edad. Métodos: Estudio transversal descriptivo con 678 escolares de 8 a 12 años de la provincia de Alicante (España. Se compararon las puntaciones en las dimensiones de calidad de vida relacionada con la salud, evaluada mediante la versión española del Child Health and Illness Profile-Child Edition, en función de las categorías ponderales (siguiendo los World Health Organization Child Growth Standards y del sexo. Resultados: El 28,2% y el 15,3% presentaron sobrepeso y obesidad, respectivamente. No se hallaron diferencias estadísticamente significativas (p > 0,05 entre las categorías ponderales en las dimensiones de calidad de vida relacionada con la salud. Conclusiones: La falta de conciencia en los niños pequeños sobre el impacto de la obesidad en la calidad de vida plantea la necesidad de intervenciones centradas en dicha salud percibida desajustada.Objective: To analyze differences in health-related quality of life across weight categories based on body mass index in boys and girls aged 8 to 12 years old. Methods: A cross-sectional study with 678 schoolchildren aged between 8 and 12 years from the province of Alicante (Spain was conducted. The scores on the dimensions of health-related quality of life, assessed by the Spanish version of the Child Health and Illness Profile-Child Edition, across the weight categories (according to the World Health Organization Child Growth Standards and sex, were compared. Results: Overweight or obesity was found in 28.2% and 15.3% of the sample, respectively. There were no statistically significant differences (p > 0.05 across the weight categories on the distinct dimensions of health-related quality of life. Conclusions: Children are unaware of the impact of obesity on quality of life. Interventions to

[Research of imidazo[1,2-a]benzimidazole derivatives. XXX. Synthesis and properties of (imidazo[1,2-a]benzimidazolyl-2)acetic acid derivatives].

Science.gov (United States)

Anisimova, V A; Tolpygin, I E; Spasov, A A; Serdiuk, T S; Sukhov, A G

2011-01-01

Ethyl esters of (9-subtituted-imidazo[1,2-a]benzimidazolyl-2)acetic acids were synthesized. The chemical properties of these esters (hydrolysis, decarboxylation, hydrazinolysis) and biological activity (fungicidal, antimicrobial, antiarrhythmic activity, and also affects on the brain rhythmogenesis) of the prepared compounds were studied.

Electron addition to alkyl cobalamins, coenzyme B/sub 12/ and vitamin B/sub 12/. [Gamma radiation

Energy Technology Data Exchange (ETDEWEB)

Rao, D N.R.; Symons, M C.R. [Leicester Univ. (UK). Dept. of Chemistry

1983-01-01

Exposure of dilute solutions of methyl and ethyl cobalamins and coenzyme B/sub 12/ in dilute solutions (D/sub 2/O+CD/sub 3/OD) to /sup 60/Co ..gamma..-rays at 77 K gave a single broad feature in the free-spin region assigned to electron-capture species with the excess electron largely confined to a ..pi..* corrin orbital. On warming above 77 K the methyl derivative gave a novel species with spectral features characteristic of an unpaired electron in the Co(dsub(x/sup 2/-y/sup 2/)) orbital. The other two substrates gave spectra due to Cosup(II)Bsub(12r) both on warming and after photolyses with visible light. The acetyl derivative gave an electron-capture species whose e.s.r. spectrum was characteristic of an electron in the Co(dsub(z/sup 2/)) orbital, which on warming above 77 K changed to the normal Cosup(II)Bsub(12r) spectrum. The cyano derivative (vitamin B/sub 12/) gave electron addition into the Co(dsub(z/sup 2/)) orbital, as evidenced by the large hyperfine coupling to /sup 13/C from /sup 13/CN ligands. On annealing, cyanide ions were lost irreversibly, Bsub(12r) being detected by e.s.r. spectroscopy. In contrast, the dicyano derivative on electron addition at 77 K gave a species containing only one /sup 13/CN ligand. Hence in this case one CN/sup -/ ligand was lost at 77 K, with no return of the dimethylbenzimidazole ligand. These results are discussed in terms of a new mechanism for electron-addition to alkyl cobalamins.

Cuestionario general de salud-12: análisis de factores en población general de Bucaramanga, Colombia General health questionnaire-12: factor analysis in the general population of Bucaramanga, Colombia

Directory of Open Access Journals (Sweden)

Adalberto Campo Arias

2007-03-01

Full Text Available ANTECEDENTES: el cuestionario general de salud de doce puntos (GHQ-12 es un instrumento diseñado para cuantificar síntomas emocionales (trastornos mentales comunes en diferentes contextos. Sin embargo, no se conoce la estructura factorial de esta versión en población colombiana. OBJETIVO: conocer la estructura de factores y la mejor forma de puntuación para el GHQ-12 en población general de Bucaramanga, Colombia. MÉTODO: una muestra probabilística de la población general, representada por 2.496 adultos entre 18 y 65 años, diligenció el GHQ-12. Se determinó la consistencia interna y los factores para las formas de puntuación ordinal (0-1-2-3 y binarias (0-0-0-1, 0-0-1-1 y 0-1-1-1. RESULTADOS: la forma ordinal mostró una consistencia interna de 0,779 y dos factores que explicaban 42,5% de la varianza. Por otro lado, la forma binaria 0-1-1-1 presentó una consistencia interna de 0,774; la forma 0-0-1-1, de 0,708; y la forma 0-0-0-1, de 0,360. Las formas binarias 0-1-1-1 y 0-0-1-1 mostraron tres factores responsables de 50,6% y 46,3%, respectivamente. La forma 0-0-0-1 no presentó una aceptable solución factorial. CONCLUSIONES: en Bucaramanga, la forma de puntuación ordinal presenta un mejor comportamiento psicométrico que las binarias. Todas las formas de puntuación muestran alta consistencia interna y aceptable solución factorial, excepto la forma 0-0-0-1 BACKGROUND: The General Health Questionnaire (GHQ-12 was designed to quantify emotional symptoms (common mental disorders in different settings. However, its factor structure is not known in Colombian population. OBJECTIVE: To establish the factor structure and the best form of punctuation for the GHQ-12 in the general population of Bucaramanga, Colombia. METHOD: A probabilistic sample of 2,496 adults from the general population in Bucaramanga, Colombia, completed the GHQ-12. The internal consistency and analysis factor were computed for the ordinal scoring (0-1-2-3 and for

Inflectional and derivational morphological spelling abilities of children with Specific Language Impairment.

Science.gov (United States)

Critten, Sarah; Connelly, Vincent; Dockrell, Julie E; Walter, Kirsty

2014-01-01

Children with Specific Language Impairment (SLI) are known to have difficulties with spelling but the factors that underpin these difficulties, are a matter of debate. The present study investigated the impact of oral language and literacy on the bound morpheme spelling abilities of children with SLI. Thirty-three children with SLI (9-10 years) and two control groups, one matched for chronological age (CA) and one for language and spelling age (LA) (aged 6-8 years) were given dictated spelling tasks of 24 words containing inflectional morphemes and 18 words containing derivational morphemes. There were no significant differences between the SLI group and their LA matches in accuracy or error patterns for inflectional morphemes. By contrast when spelling derivational morphemes the SLI group was less accurate and made proportionately more omissions and phonologically implausible errors than both control groups. Spelling accuracy was associated with phonological awareness and reading; reading performance significantly predicted the ability to spell both inflectional and derivational morphemes. The particular difficulties experienced by the children with SLI for derivational morphemes are considered in relation to reading and oral language.

Inteligencia emocional y resiliencia: su influencia en la satisfacción con la vida en estudiantes universitarios

OpenAIRE

Cejudo, Javier; López-Delgado, M. Luz; Rubio, M. Jesús

2016-01-01

El presente estudio pretende aportar evidencias sobre la relación entre IE, resiliencia y bienestar. Se cuenta con una muestra de 432 estudiantes universitarios. El rango de edad oscila entre 17 y 59 años, con una media de 21,77 (DT=5,12). Se recogió información mediante 3 autoinformes: el Trait Meta-Mood Scale-24, la Escala de Resiliencia de Wagnild y Young y la Escala de Satisfacción con la Vida de Diener, Emmons, Larsen y Griffin. Con respecto a la asociación de la satisfacción con ...

Efecto del fotoperiodo y la intensidad lumínica sobre la esporulación de Peronospora sparsa Berkeley, bajo condiciones controladas

Directory of Open Access Journals (Sweden)

Soto S. Johana Carolina

2009-08-01

Full Text Available

El mildeo velloso de la rosa, producido por Peronospora sparsa, es una de las enfermedades más limitantes y costosas en los cultivos comerciales de rosa en Colombia. La estrecha relación de la enfermedad con las condiciones climáticas ha llevado a realizar estudios del parásito en condiciones microclimáticas controladas. Esta investigación buscó ahondar en el conocimiento de la biología del mildeo velloso de la rosa, evaluando para ello el efecto del fotoperiodo y la intensidad lumínica sobre la esporulación del parásito cultivado en folíolos de rosa en cámara húmeda bajo condiciones ambientales controladas. Se evaluaron los siguientes fotoperiodos: 24 horas bajo una intensidad lumínica de 1.000 lux; 8, 12 y 24 horas luz a 790 lux; 8, 16 y 24 horas a 560 lux; 12 horas a 120 lux, y finalmente 0 horas luz (oscuridad total. La esporulación se vio favorecida por fotoperiodos de 8 a 16 horas a 560 lux, y presentó un alto desempeño con periodos de 12 horas a 790 lux. La exposición continua a la luz demostró tener un efecto inhibidor sobre la esporulación de P. sparsa. Así mismo, determinó la producción de esporangios con características atípicas, como bajo contenido citoplasmático y menor tamaño.

Ab initio molecular dynamics study of lithium diffusion in tetragonal Li{sub 7}La{sub 3}Zr{sub 2}O{sub 12}

Energy Technology Data Exchange (ETDEWEB)

Andriyevsky, B., E-mail: bohdan.andriyevskyy@tu.koszalin.pl [Faculty of Electronics and Computer Sciences, Koszalin University of Technology, 2 Śniadeckich Str., PL-75-453, Koszalin (Poland); Institute of Electrochemistry, Ulm University, Albert-Einstein-Allee 47, D-89069, Ulm (Germany); Doll, K. [Institute of Electrochemistry, Ulm University, Albert-Einstein-Allee 47, D-89069, Ulm (Germany); Institute of Theoretical Chemistry, Pfaffenwaldring 55, D-70569, Stuttgart (Germany); Jacob, T. [Institute of Electrochemistry, Ulm University, Albert-Einstein-Allee 47, D-89069, Ulm (Germany); Helmholtz Institute Ulm (HIU) for Electrochemical Energy Storage, Albert-Einstein-Allee 11, D-89081, Ulm (Germany)

2017-01-01

Using ab initio density functional theory the thermally-stimulated migration of lithium ions in the garnet-type material Li{sub 7}La{sub 3}Zr{sub 2}O{sub 12} is investigated. The methods of ab initio molecular dynamics have been applied to calculate the lithium ion self-diffusion coefficient and the diffusion barriers as function of lithium ion concentration. The concentration of lithium in the initial Li{sub 7}La{sub 3}Zr{sub 2}O{sub 12} crystal unit cell is varied from 53 to 59 atoms, where 56 lithium atoms represent the stoichiometric concentration. Almost monotonous dependencies of the main characteristics on the number of lithium atoms N{sup (Li)} have been found, except for a non-monotonous peculiarity of the stoichiometric compound (N{sup (Li)} = 56). Finally, the influence of the unit cell volume change on lithium ion diffusion parameters as well as lithium ion hopping rates has been studied. - Highlights: • Partial lithium atoms subtraction from LLZO increases diffusion coefficient D{sup (Li)}. • Partial subtraction of lithium atoms from LLZO decreases activation energy E{sub a}{sup (Li)}. • Activation energy E{sub a}{sup (Li)} is the smallest for tetrahedral oxygen surrounding. • Compression of LLZO leads to a decrease of lithium ion diffusion coefficient D{sup (Li)}.

El rol mediador de la implicación escolar sobre el apoyo del profesorado y la satisfacción con la vida

Directory of Open Access Journals (Sweden)

Estibaliz Ramos-Díaz

2016-12-01

Full Text Available La visión de la escuela como un entorno promotor del bienestar personal ha generado un gran interés en el ámbito de la investigación psicoeducativa por el estudio de variables relacionadas con el desarrollo positivo del alumnado. Este trabajo analiza mediante un modelo estructural tanto la influencia directa como indirecta del apoyo del profesorado a través de la implicación escolar sobre la satisfacción con la vida. Participaron en el estudio 1250 estudiantes de Educación Secundaria Obligatoria, de entre 12 y 15 años (Medad=13.72, DT=1.09, seleccionados aleatoriamente en la Comunidad del País Vasco, de los cuales el 49% eran chicos mientras que el 51% eran chicas. Los resultados confirman la influencia que el apoyo del profesorado ejerce sobre la satisfacción con la vida a través de la implicación escolar (X²(51=219.743, p<.001; GFI=.972; CFI=.965; TLI=.954; SRMR=.031; RMSEA=.051. Para finalizar, se discuten los resultados y sus implicaciones, así como las perspectivas futuras de investigación.

Atomic scale studies of La/Sr ordering in La2-2xSr1+2xMn2O7 single crystals

KAUST Repository

Roldan, Manuel

2016-12-21

Many fascinating properties of materials depend strongly on the local chemical environment. This is the case for many complex oxides, such as materials with colossal magnetoresistance, where small variations of composition at the atomic scale can affect drastically the macroscopic properties. The main objective of the present work is to analyze the local chemical composition with atomic resolution and to find out if any underlying chemical order is in any way connected to the magnetic properties of double perovskite La2-2xSr1+2xMn2O7 (LSMO) manganite oxides. For these compounds, charge and orbital ordering are observed for some doping values near x = 0.50 [1, 2]. For this purpose, we have use aberration corrected scanning transmission electron microscopy (STEM) combined with electron energy-loss spectroscopy (EELS) measurements and also theoretical simulations. We have compared different compositions within three distinct magnetic regions of the phase diagram: a ferromagnetic metallic sample with x=0.36, an insulating, antiferromagnetic (AF) x=0.56 and an additional AF x=0.50 sample which also exhibits charge ordering. High angle annular dark-field (HAADF) images, also known as Z-contrast, confirm that our single crystals exhibit high crystal quality. No secondary phases or defects are observed. Figure 1 displays an atomic resolution image obtained with the c-axis perpendicular to the electron beam of a x=0.50 sample. The perovskite (P)-like planes and the rock salt (R)-like planes are clearly observed, highlighted in green and red, respectively, on the image. The P-like planes exhibit a slightly high contrast, suggesting a possible La enrichment. EELS atomic resolution maps (inset) support a high degree of La segregation on those planes, while R-like planes are Sr rich. However, due to dechanneling of the beam, detailed image simulations are essential to accurately quantify the local chemical composition in an atomic column-by-atomic column fashion. For all our

Dielectric, piezoelectric, and ferroelectric properties of grain-orientated Bi3.25La0.75Ti3O12 ceramics

International Nuclear Information System (INIS)

Liu Jing; Shen Zhijian; Yan Haixue; Reece, Michael J.; Kan Yanmei; Wang Peiling

2007-01-01

By dynamic forging during Spark Plasma Sintering (SPS), grain-orientated ferroelectric Bi 3.25 La 0.75 Ti 3 O 12 (BLT) ceramics were prepared. Their ferroelectric, piezoelectric, and dielectric properties are anisotropic. The textured ceramics parallel and perpendicular to the shear flow directions have similar thermal depoling behaviors. The d 33 piezoelectric coefficient of BLT ceramics gradually reduces up to 350 deg. C; it then drops rapidly. The broadness of the dielectric constant and loss peaks and the existence of d 33 above the permittivity peak, T m , show that the BLT ceramic has relaxor-like behavior

Demand management in steam generation?; Administracion de la demanda en la generacion de vapor?

Energy Technology Data Exchange (ETDEWEB)

Plauchu L., A.; Plauchu A., J. A. [Ingenieros consultores (Mexico)

1997-12-31

Energy management has acquired capital importance in all the branches of the industrial activity and services either private o public and it has been, from years behind, more familiar the technology for the demand control in the electric power distribution systems, with excellent results in the energy conservation and economy. The rate of consumption for the different forms of energy shows the prevalence of the thermal energy in a variety of end uses. Not much or almost nothing has been said of the term Demand Management or Control in Steam Generation although 12% of the total energy supply is used for this purpose. Steam demand management and control can avoid unnecessary investments that bring along the increment of operational and maintenance problems and it is for sure that it will always give raise to a more rational and economical utilization of the real capacity of steam generation. A real case is commented. [Espanol] La administracion de la energia ha cobrado importancia capital en todos los giros de actividad industrial y de servicios, privados y publicos y es de varios anos atras cada vez mas familiar la tecnologia en el control de demanda en los sistemas de distribucion de energia electrica, con magnificos resultados en el ahorro, energetico y economico. La relacion de consumos para las diferentes formas de energia muestra el predominio de la energia termica en una variedad de usos finales. Poco o nada oimos del termino Administracion o Control de Demanda en la Generacion de Vapor aun cuando el 12% de la oferta total de energia tiene como destino esta aplicacion. La administracion y control de la demanda de vapor puede evitar inversiones innecesarias e incremento de problemas de operacion y mantenimiento y con seguridad reportaran siempre una utilizacion mas racional y economica de la capacidad real de generacion de vapor, se comenta un caso real.

Demand management in steam generation?; Administracion de la demanda en la generacion de vapor?

Energy Technology Data Exchange (ETDEWEB)

Plauchu L, A; Plauchu A, J A [Ingenieros consultores (Mexico)

1998-12-31

Energy management has acquired capital importance in all the branches of the industrial activity and services either private o public and it has been, from years behind, more familiar the technology for the demand control in the electric power distribution systems, with excellent results in the energy conservation and economy. The rate of consumption for the different forms of energy shows the prevalence of the thermal energy in a variety of end uses. Not much or almost nothing has been said of the term Demand Management or Control in Steam Generation although 12% of the total energy supply is used for this purpose. Steam demand management and control can avoid unnecessary investments that bring along the increment of operational and maintenance problems and it is for sure that it will always give raise to a more rational and economical utilization of the real capacity of steam generation. A real case is commented. [Espanol] La administracion de la energia ha cobrado importancia capital en todos los giros de actividad industrial y de servicios, privados y publicos y es de varios anos atras cada vez mas familiar la tecnologia en el control de demanda en los sistemas de distribucion de energia electrica, con magnificos resultados en el ahorro, energetico y economico. La relacion de consumos para las diferentes formas de energia muestra el predominio de la energia termica en una variedad de usos finales. Poco o nada oimos del termino Administracion o Control de Demanda en la Generacion de Vapor aun cuando el 12% de la oferta total de energia tiene como destino esta aplicacion. La administracion y control de la demanda de vapor puede evitar inversiones innecesarias e incremento de problemas de operacion y mantenimiento y con seguridad reportaran siempre una utilizacion mas racional y economica de la capacidad real de generacion de vapor, se comenta un caso real.

La hospitalización terapéutica obligatoria en el control de la tuberculosis

Directory of Open Access Journals (Sweden)

Joan R. Villalbí

2016-03-01

Full Text Available Este trabajo describe las acciones de los servicios de salud pública de la ciudad de Barcelona para evitar la transmisión de la tuberculosis por pacientes bacilíferos incumplidores utilizando las posibilidades de la Ley 3/1986. Se basan en la resolución de la autoridad sanitaria de la necesidad de su localización y hospitalización terapéutica obligatoria para administrar el tratamiento, movilizando la colaboración policial, comunicándolo a la persona afectada y pidiendo al Juzgado de lo Contencioso Administrativo su ratificación. Se describen el proceso y las características de los casos. Desde julio de 2006 hasta junio de 2015, a lo largo de 9 años, se ha activado sólo en 12 ocasiones. Se valora que se ha usado con prudencia y proporcionalidad, y que ha permitido tratar a pacientes que comportaban riesgo en su entorno, reduciendo así la transmisión de la infección.

Caracterización del desarrollo psicoafectivo en niños y niñas escolarizados entre 6 y 12 años de edad de estrato socioeconómico bajo de la ciudad de Barranquilla

Directory of Open Access Journals (Sweden)

Luz Elena López

2007-01-01

Full Text Available En este estudio descriptivo se tomó una muestra al azar de 125 niños y niñas de 1º, 2º, 3º y 4º grado de la Institución Educativa San Vicente de Paúl, de estrato bajo de la ciudad de Barranquilla. La edad de los estudiantes oscilaba entre los 6 y 12 años (etapa de latencia. A los niños se les aplicó una prueba proyectiva de personalidad denominada Wartegg y una técnica de observacional diseñada por la investigadora. La investigación tenía como objetivo general caracterizar los elementos del desarrollo psicoafectivo en niños y niñas escolarizados con edades entre 6 y 12 años de estrato socioeconómico bajo de la ciudad de Barranquilla basados en la teoría de orientación psicodinámica. Se encontraron, sin embargo, dos resultados significativos: Dificultades en el desplazamiento de la energía libidinal, lo cual interfiere en las posibilidades de establecer mejores relaciones interpersonales y, a su vez, en el desarrollo de pocas actividades competitivas, que afecta su capacidad de logro. Además, de acuerdo con las diferencias con respecto a su sexo, en los resultados no se evidenciaron aspectos relevantes y muy diferentes en el desarrollo psicoafectivo de niños y niñas.

Efecto de la jalea real sobre la proliferación de los linfocitos humanos

OpenAIRE

del Valle Pérez, Lázaro O; Macías Abraham, Consuelo; Esquivel Suárez, Ileana; Rodríguez Amado, Jacqueline; Alpízar Olivares, Yulién; Torres Leyva, Isabel

2001-01-01

Se estudió el efecto in vitro de la jalea real (JR) sobre los linfocitos de 10 donantes voluntarios del Banco de Sangre del Instituto de Hematología e Inmunología mediante la prueba de transformación linfoblástica con el empleo de timidina tritiada. Se cultivaron 100 mL de la muestra (2 ´ 106 linf/mL) en las siguientes condiciones experimentales: 100 mL de RPMI 1640 suplementado con suero fetal bovino al 20 %, diluciones dobles de la JR (tableta 100 mg) desde 1:2 hasta 1:4096 respectivamente....

Analysis of the activation profile of dendritic cells derived from the bone marrow of interleukin-12/interleukin-23-deficient mice

Science.gov (United States)

Bastos, Karina R B; de Deus Vieira de Moraes, Luciana; Zago, Cláudia A; Marinho, Cláudio R F; Russo, Momtchilo; Alvarez, José M M; D'Império Lima, Maria R

2005-01-01

We have previously shown that macrophages from interleukin (IL)-12p40 gene knockout (IL-12/IL-23−/−) mice have a bias towards the M2 activation profile, spontaneously secreting large quantities of transforming growth factor-β1 (TGF-β1) and producing low levels of nitric oxide (NO) in response to lipopolysaccharide (LPS) and interferon-γ (IFN-γ). To verify whether the activation profile of dendritic cells (DCs) is also influenced by the absence of IL-12/IL-23, bone marrow-derived DCs from IL-12/IL-23−/− and C57BL/6 mice were evaluated. At first we noticed that ≈ 50% of the C57BL/6 DCs were dead after LPS-induced maturation, whereas the mortality of IL-12/IL-23−/− DCs was < 10%, a protective effect that diminished when recombinant IL-12 (rIL-12) was added during maturation. Similarly to macrophages, mature IL-12/IL-23−/− DCs (mDCs) produced higher levels of TGF-β1 and lower levels of NO than C57BL/6 mDCs. NO release was IFN-γ-dependent, as evidenced by the poor response of IFN-γ−/− and IL-12/IL-23−/−IFN-γ−/− mDCs. Nevertheless, IFN-γ deficiency was not the sole reason for the weak NO response observed in the absence of IL-12/IL-23. The high level of TGF-β1 secretion by IL-12/IL-23−/− mDCs could explain why exogenous IFN-γ partially restored the NO production of IFN-γ−/− mDCs, while IL-12/IL-23−/− IFN-γ−/− mDCs remained unresponsive. We also showed that CD4+ T-cell proliferation was inhibited by C57BL/6 mDCs, but not by IL-12/IL-23−/− mDCs. IFN-γ and NO appear to mediate this antiproliferative effect because this effect was not observed in the presence of mDCs from IFN-γ−/− or IL-12/IL-23−/− IFN-γ−/− mice and it was attenuated by aminoguanidine. We conclude that the presence of IL-12/IL-23 during LPS-induced maturation influences the activation profile of DCs by a mechanism that is, only in part, IFN-γ dependent. PMID:15804287

El cuerpo en la lingüística cognitiva. La metáfora conceptual y el embodiment

Directory of Open Access Journals (Sweden)

Daniela Soledad Gonzalez

2017-11-01

Full Text Available El presente trabajo da cuenta del modo en el que la lingüística cognitiva aborda el tema del cuerpo en relación con el lenguaje, entendido este como un correlato del pensamiento. Uno de los ejes de abordaje del lenguaje que caracteriza a este enfoque teórico es el de la metáfora conceptual, noción postulada por Lakoff y Johnson (2001. Los autores conciben la metáfora como un fenómeno del pensamiento que se refleja en el lenguaje, que está omnipresente en la vida cotidiana y que permite la estructuración de la experiencia. La experiencia a la que hacen referencia es, fundamentalmente, corporal. La influencia de la experiencia corporal en la conceptualización recibe el nombre de embodiment o embodied mind (Lakoff, 1987: 12.

Tratamiento directamente observado de la tuberculosis en un hospital de la Ciudad de Buenos Aires

Directory of Open Access Journals (Sweden)

Claudio González

2012-10-01

Full Text Available Se describe la experiencia en la aplicación del tratamiento directamente observado de tuberculosis (TDO en el período 1/1/1979-31/12/2009 y la comparación de los resultados obtenidos en el periodo 1979-1999 versus los de 2000- 2009. En un hospital de la Ciudad de Buenos Aires, 582 pacientes HIV negativos recibieron inicialmente rifampicina, isoniazida, pirazinamida y etambutol o estreptomicina. En la segunda fase 424 de estos pacientes tratados entre 01/01/1979 y 31/12/1999 (G1, recibieron esquemas bisemanales con rifampicina/isoniazida o isoniazida/estreptomicina y otros 158 pacientes, tratados entre 01/01/2000 y 31/12/2009 (G2 recibieron un esquema bisemanal o trisemanal con rifampicina/isoniazida. Se siguieron las recomendaciones de los programas de control de la Nación y la Ciudad. Los pacientes bajo TDO tuvieron tasas de tratamiento completo más elevadas (82.8% versus 48.7%, (p < 0.0001 con respecto a otros 483, que siguieron tratamiento autoadministrado (AUTO; la edad promedio fue de 36.3 ± 15.3 años, 63.1% eran varones y 69.4% tenían nacionalidad argentina. Presentaron tratamiento previo el 8.9%, comorbilidades el 6.1% y el 70.6% de las formas pulmonares fueron confirmadas bacteriológicamente. El 9.5% presentó efectos adversos a drogas y el sexo masculino presentó mayor frecuencia de abandonos (p = 0.004. Con respecto al G1, en el G2 hubo menor proporción de pacientes argentinos (48.7% vs. 77.1%, (p ≤ 0.0001, mayor frecuencia de comorbilidades (10.7% vs. 4.4%, (p = 0.005, de formas clínicas pulmonares con confirmación bacteriológica (95% vs. 87%, (p = 0.02 y de efectos adversos a drogas (17% vs. 6.6%, (p ≤ 0.0001. Hallamos tasas de cumplimiento total elevadas en TDO (82.8%, similares a las otras publicaciones.

Nueva formula matemática para el calculo de la proteinuria de 24 horas en niños

Directory of Open Access Journals (Sweden)

José R. Salabarría

1996-08-01

Full Text Available Se elaboró una fórmula matemática para la cuantificación de la excreción urinaria de proteínas en 24 horas en niños y adolescentes, derivada de la relación proteinuria creatinuria (RPC. Se procesaron 104 muestras de orina de 24 horas, las cuales se dividieron en 2 grupos de acuerdo con la excreción diaria de creatinina. La proteinuria de 24 horas se determinó en cada grupo por el método tradicional y mediante la fórmula propuesta. Se obtuvo una excelente correlación (r = 0,994 y una elevada concordancia en el grupo con recolecciones adecuadas de orina, no así en el grupo con recolecciones inadecuadas (r = 0,896. Al comparar las RPC en 30 muestras de orina obtenidas en 3 diferentes períodos, con la RPC de 24 horas correspondiente se obtuvo una elevada correlación (r 0,99; no obstante la que guardó mayor identidad fue la del período comprendido entre las 7:00 a.m. y 12:00 m.A mathematical formula for the quantification of 24-hour urinary protein excretion in children and adolescents, derived from the proteinuria-creatinuria relation (PCR was elaborated. 104 urine specimens were processed and divided into two groups according to daily creatinine excretion. 24-hour proteinuria was determined in each group by the traditional method and by the formula proposed. An excelent correlation (r=0,994 and an elevated correspondence in the group with adequate urine collections were obtained, but it was not so in the group with inadequate collections (r=0,896. On comparing the PCR in 30 urine specimens collected at three different periods with the corresponding 24-hour PCR, an elevated correlation (r 0,99 was obtained; however, the one with the greatest identity was that collected between 7:00 a.m. and 12:00 m.

La política administrativo-religiosa del estado visigodo en el Sureste : el caso de la creación de la sede episcopal Elotana

Directory of Open Access Journals (Sweden)

Jesús Peidro Blanes

2008-01-01

Full Text Available En el presente trabajo se analizan las actas de varios concilios eclesiásticos visigodos, con el objetivo de delimitar de forma más precisa los obispados de Vicentius de Begastri y Sanabilis de Elo. A partir del análisis cruzado de las listas episcopales contenidas en dichos concilios se lanza la hipótesis de la posible autoría de Witerico de las nuevas sedes y las implicaciones historiográficas derivadas de ello. Asimismo, se presenta un estado de la cuestión acerca de la ubicación de la sede elotanaIn this paper we analyze the acts of several ecclesiastical councils of the visigothic period, with the purpose of delimiting the bishoprics of Vicentius of Begastri and Sanabilis of Elo. From the episcopal lists analysis, we hypothetisize of the Witeric’s responsibility of these new seats and the historiographical implications derived. Also, we explain several theories about the location of the elotana seat.

Modelo hidrogeofísico de la cuenca sur de La Habana

Directory of Open Access Journals (Sweden)

González Espinosa Jacqueline

2000-08-01

Full Text Available

12pt; mso-ansi-language: EN-US;" lang="EN-US">A hidrogeophysical model of the South Basin of La Habana is presented as the result of multivaried statistical processing applied to well logging and transmisivity data from pumping test Through combining Euclidian Group Analysis, correlation analysis and Uvarov relationships it was possible to separate the structured components of the different variables and: to define the correlation between the geophysical parameters of the well and the filtration velocity of the groundwater, these coefficients are above 0.8; to establish the relation between Dar-Zarrouk parameters (from electrical well logging and transmisivity (from pumping tests. The former one was estimated from longitudinal conductance. Within less than 15% of error. It is shown that the applied processing is suscefult even in the study of karstic aquifers. 12pt;">Where heterogeneity and anisotropy are characteristics.

Como resultado del procesamiento estadístico multivariado aplicado a los registros geofísicos de pozo y a los datos de transmisividad obtenidos de pruebas de bombeo, se presenta un modelo hidrogeofísico de la Cuenca Sur de La Habana que permite sintetizar la información hidrodinámica y geofísica existente. La aplicación combinada del análisis euclidiano de agrupación, del análisis de correlación y de las relaciones de Uvarov, permitió separar la componente estructurada de las variables estudiadas y definir la correlación entre parámetros geofísicos de pozo y la velocidad de filtración de las aguas subterr

Enfoque por tareas para la enseñanza de las vanguardias en la clase de E/LE. Propuesta de actividades

Directory of Open Access Journals (Sweden)

Luz Souto

2015-10-01

Full Text Available El estudio de las vanguardias a través de su contexto histórico y de sus producciones artísticas se propone como una actividad interdisciplinar, en la que los alumnos no solo se centren en el aspecto literario sino que también observen cómo se lleva adelante la ruptura de principios de siglo XX respecto a la pintura, el cine, la arquitectura y la música, mediante el uso de la lengua española. Este artículo propone clases que se impartan de manera participativa, desde la lectura y el análisis conjunto de los manifiestos, pasando por la visionado de cortos, el audio de música de vanguardia y la visualización de obras de arte. Mediante la integración de literatura y uso de la lengua, se propone un enfoque por tareas que derive en la propuesta de actividades de creación, en las mismas se potenciarán los perfiles de cada alumno.

EL PROCESO DE ENSEÑANZA-APRENDIZAJE DE LA DERIVADA EN LA CARRERA DE COMERCIO EXTERIOR Y NEGOCIOS INTERNACIONALES DE LA UNIVERSIDAD LAICA ELOY ALFARO DE MANABÍ

Directory of Open Access Journals (Sweden)

Miguel Escalona-Reyes

2017-01-01

Full Text Available La Educación Superior en Ecuador se encuentra en un proceso de perfeccionamiento,  debido a la necesaria transformación que debe asumir para asumir un nuevo redimensionamiento de la misión de la universidad contemporánea ante los retos del nuevo siglo. Uno de los cambios fundamentales radica en el perfeccionamiento del currículo de las carreras, y con ello de los programas de las diferentes materias; para el caso del estudio de la Matemática, no puede desvincularse su estudio del contexto social y el proyecto social en que se desarrolla el proceso pedagógico de los profesionales en formación, de la misma manera que no se puede concebir como algo abstracto y general, debiendo conjugarse con los objetivos y con las tareas que dimanan de los resultados parciales del espacio y del tiempo en el que transcurren. Uno de los temas de esta asignatura, esenciales para el estudiante de la carrera de Comercio Exterior y Negocios Internacionales, es la derivada, ya que permite aplicar dicho conocimiento en la resolución de ejercicios y problemas que son afín con la vida profesional del estudiante. No obstante, se ha constatado varias insuficiencias en el proceso de enseñanza aprendizaje de estos contenidos en esta carrera; motivo por el cual se realiza esta investigación, donde se presenta una Alternativa Metodológica para favorecer dicho proceso.PALABRAS CLAVE: Didáctica de la Matemática; Derivada; Formación Profesional.THE TEACHING-LEARNING PROCESS OF DERIVATIVES IN THE CARRER OF FOREIGN TRADE AND INTERNATIONAL BUSINESS FROM THE UNIVERSIDAD LAICA ELOY ALFARO DE MANABÍABSTRACTHigher Education in Ecuador is involved in a process of improvement, due to the necessary transformation which must be followed to assume a new downsizing of the mission of nowadays university in the challenges of the new century. One of the main changes lies in the improvement of the curriculum of courses, and the syllabus in different subjects; respected to the case

Contribution à la caractérisation ultrasonore en vue de la détection ...

African Journals Online (AJOL)

La détection de ces défauts de gondolement a été menée par un analyseur à ultrasons SONATEST Site-scan-140 doté d'un palpeur de type piézo-électrique KrautKramer de fréquence intrinsèque de 2MHz avec un diamètre de 12mm. La caractérisation des paramètres optimums d'étalonnage par la méthode de contrôle ...

Multi-component Ce doped (Gd,Y,La,Lu)3(AlGaSc)5O12 garnets – A new story in the development of scintillating single crystalline film screens

International Nuclear Information System (INIS)

Zorenko, Yu.; Gorbenko, V.; Savchyn, V.; Zorenko, T.; Fedorov, A.; Wrzesinski, H.; Vasylkiv, Ya.

2013-01-01

The paper is dedicated to development of the scintillators based on single crystalline films of Ce doped (GdLaYLu) 3 (AlGaSc) 5 O 12 multi-component garnets onto Gd 3 Ga 5 O 12 substrates using the liquid phase epitaxy method. -- Highlights: •Growth of Ce doped (GdYLaLu) 3 (AlGaSc) 5 O 12 garnets films by LPE method. •Luminescent and scintillation properties of Ce doped (GdYLaLu) 3 (AlGaSc) 5 O 12 films. •Influence of Pb 2+ flux related impurity on the light yield of Ce 3+ emission

INFLUENCIA DE LA CARGA ORGÁNICA SOBRE LA EFICIENCIA DE REACTORES RBC DE TRES ETAPAS EN EL TRATAMIENTO DE UN EFLUENTE INDUSTRIAL SINTÉTICO

Directory of Open Access Journals (Sweden)

Elisabeth Behling de Calmón

2012-01-01

Full Text Available El presente artículo incluye el estudio de la influencia de la carga orgánica (CO sobre la eficiencia de reactores biológicos rotativos de contacto (RBC, aerobios de tres etapas, al tratar un efluente industrial sintético, con la finalidad de establecer la adecuación del efluente final con respecto a los límites de descarga establecidos en la normativa de Venezuela. Durante la experimentación, se evaluaron pH, alcalinidad total, oxígeno disuelto, demanda biológica de oxígeno (DBO, demanda química de oxígeno (DQO, sólidos suspendidos totales (SST, nitrógeno total Kjeldahl (NTK, NH 4 + , NO 2 - y NO 3 - , de acuerdo con los métodos estándares. La variación de la CO aplicada se obtuvo mediante modificación del tiempo de retención hidráulico (TRH, (24, 12 y 6 h, y se mantuvo constante la DQO de entrada (influente sintético de sacarosa+ urea. La mayor eficiencia de remoción de DQO se obtuvo para un CO global de 11,68 gDQO/m 2 .d (96,25%; TRH=12 h. Para los TRH 24 y 12 h, la eficiencia de remoción global de N-total fue de 66,92 y 62,95%, respectivamente. La mayor remoción de C y de N se obtuvo en la primera etapa de los reactores y se logró cumplir con el límite venezolano permisible de descarga para DQO (<350 mg/L. La posible ocurrencia del proceso de nitrificación repercutió sobre el aumento de las concentraciones de nitrógeno inorgánico en el efluente final.

ADAPTACIÓN DE LA BATERÍA DE EVALUACIÓN DE LA MEMORIA SEMÁNTICA EN LA DEMENCIA DE TIPO ALZHEIMER (EMSDA A LA POBLACIÓN DE LA CIUDAD DE BUENOS AIRES

Directory of Open Access Journals (Sweden)

LINA GRASSO

2011-01-01

Full Text Available Se llevó a cabo la adaptación de la Batería pa ra la Evaluación de la Memoria Semántica en Demencia de tipo Alzheimer (Peraita, González Labra, Sánchez Bernardos & Galeote Moreno, 20001 para su aplicación en la Ciudad de Buenos Aires (República Argentina. Esta batería permite evaluar mediante pruebasde modalidad visual, verbal y auditiva, el deterioro del conocimiento de seis categorías semánticas de seres vivientes y no vivientes. Ha sido desarrollada para población de habla hispana con la finalidad de evaluar el deterioro semántico en la Demencia de tipo Alzheimer. Su valor radica en que complementa la evaluación neuropsicológica, donde los aspectos de la memoria semántica por lo general están poco representados, otorgándole valor predictivo al posibilitar la detección temprana de determinadas patologías en las que se encuentra afectado ese sistema de la memoria. Se administró la batería a 30 sujetos sin deterioro cognitivo que tenían entre 61 y 88 años de edad y un promedio de 12 años de escolaridad. Los participantes fueron cuidadosamente seleccionados y se excluyeron a quienes pudieran presentar indicadores de deterioro cognitivo. La evaluación de los ítemes se realizó en base a la frecuencia de las respuestas correctas. Se tomó este criterio considerando que se trata de variables categóricas y el tamaño de la muestra. Se estimó la proporción de respuestas correctas en las seis categorías y dominios de seres vivientes y seres no vivientes. Los nue vos ítemes fueron seleccionados respetando la estructura de la batería y considerando su correlación entre las distintas pruebas.

NYC Reservoirs Watershed Areas (HUC 12)

Data.gov (United States)

U.S. Environmental Protection Agency — This NYC Reservoirs Watershed Areas (HUC 12) GIS layer was derived from the 12-Digit National Watershed Boundary Database (WBD) at 1:24,000 for EPA Region 2 and...

Vida empresarial colombiana después de la Gran recesión

Directory of Open Access Journals (Sweden)

Ana María Yepes Restrepo

2011-12-01

Full Text Available El presente artículo se derivó del trabajo realizado en la materia “Estudios Empresariales Colombianos”, como un acercamiento a la historia de los empresarios colombianos y al desarrollo de la industria en el país al comenzar el siglo xx. Para ello, utilicé como fuente primaria la hemeroteca de la Sala de Patrimonio Documental de la Universidad Eafit, específicamente noticias del periódico El Diario de abril de 1932.

Viability of Lactobacillus acidophilus LA-5 and Bifidobacterium bifidum BB-12 in Rice Pudding

Directory of Open Access Journals (Sweden)

Tulay Ozcan

2010-06-01

Full Text Available The purpose of this study was to determine the survival of two probiotic micro-organisms (Lactobacillus acidophilus LA-5 and Bifidobacterium bifidum BB-12 in a rice pudding, the impact of these bacteria on hygienic quality, and to verify the perspectives of the product with regard to consumer sensorial acceptance. The products were monitored for the microbial population, pH, titratable acidity and consistency, during storage at 4±1 °C for up to 21 days. Sensory preference was also tested. Even though the viability of the probiotic bacteria was reduced over 21 days of storage, the viable cell concentrations were still sufficient to obtain the desired therapeutic impact. The counts of yeasts-moulds and Staphylococcus spp. decreased in samples with added probiotic bacteria. The sensorial properties of probiotic rice pudding demonstrated similar acceptability to the control up to 14 days and declined thereafter. Rice pudding was considered suitable food for the delivery of probiotic micro-organisms, with sufficient viability and acceptable sensory characteristics.

Structural, magneto-optical properties and cation distribution of SrBi{sub x}La{sub x}Y{sub x}Fe{sub 12−3x}O{sub 19} (0.0 ≤ x ≤ 0.33) hexaferrites

Energy Technology Data Exchange (ETDEWEB)

Auwal, I.A. [Department of Chemistry, Fatih University, 34500 B. Çekmece, İstanbul (Turkey); Güngüneş, H. [Department of Physics, Hitit University, 19030 Çevre Yolu Bulvarı, Çorum (Turkey); Güner, S. [Department of Physics, Fatih University, 34500 B. Çekmece, İstanbul (Turkey); Shirsath, Sagar E. [Spin Device Technology Center, Faculty of Engineering, Shinshu University, 380-8553 Nagano (Japan); Sertkol, M. [Department of Physics Engineering, Istanbul Technical University, 34469 Maslak (Turkey); Baykal, A., E-mail: hbaykal@fatih.edu.tr [Department of Chemistry, Fatih University, 34500 B. Çekmece, İstanbul (Turkey)

2016-08-15

Highlights: • SrBi{sub x}La{sub x}Y{sub x}Fe{sub 12−3x}O{sub 19} (0.0 ≤ x ≤ 0.33) hexaferrites have been prepared by sol-gel autocombustion. • XRD patterns show that SrBi{sub x}La{sub x}Y{sub x}Fe{sub 12−3x}O{sub 19} (0.0 ≤ x ≤ 0.33) hexaferrites exhibit hexagonal structure. • The intrinsic coercivity (H{sub ci}) above 15000 Oe reveals that all samples are magnetically hard materials. - Abstract: SrBi{sub x}La{sub x}Y{sub x}Fe{sub 12−3x}O{sub 19} (0.0 ≤ x ≤ 0.33) hexaferrites were produced via sol-gel auto combustion. XRD patterns show that all the samples are single-phase M-type strontium hexaferrite (SrM). The magnetic hysteresis (σ-H) loops revealed the ferromagnetic nature of nanoparticles (NPs). The coercive field decreases from 4740 Oe to 2720 Oe with increasing ion content. In particular, SrBi{sub x}La{sub x}Y{sub x}Fe{sub 12−3x}O{sub 19} NPs with x = 0.0, 0.1, 0.2 have suitable magnetic characteristics (σ{sub s} = 62.03–64.72 emu/g and H{sub c} = 3105–4740 Oe) for magnetic recording. The intrinsic coercivity (H{sub ci}) above 15000 Oe reveals that all samples are magnetically hard materials. Tauc plots were used to specify the direct optical energy band gap (E{sub g}) of NPs. The E{sub g} values are between 1.76 eV and 1.85 eV. {sup 57}Fe Mössbauer spectroscopy data, the variation in line width, isomer shift, quadrupole splitting, relative area and hyperfine magnetic field values on Bi{sup 3+} La{sup 3+} and Y{sup 3+} substitutions have been determined.

Vitamin B12 Phosphate Conjugation and Its Effect on Binding to the Human B12 -Binding Proteins Intrinsic Factor and Haptocorrin

DEFF Research Database (Denmark)

Ó Proinsias, Keith; Ociepa, Michał; Pluta, Katarzyna

2016-01-01

The binding of vitamin B12 derivatives to human B12 transporter proteins is strongly influenced by the type and site of modification of the cobalamin original structure. We have prepared the first cobalamin derivative modified at the phosphate moiety. The reaction conditions were fully optimized...... and its limitations examined. The resulting derivatives, particularly those bearing terminal alkyne and azide groups, were isolated and used in copper-catalyzed alkyne-azide cycloaddition reactions (CuAAC). Their sensitivity towards light revealed their potential as photocleavable molecules. The binding...... abilities of selected derivatives were examined and compared with cyanocobalamin. The interaction of the alkylated derivatives with haptocorrin was less affected than the interaction with intrinsic factor. Furthermore, the configuration of the phosphate moiety was irrelevant to the binding process....

Cómo cultivar la ciudadanía cosmopolita en la Educación Superior. El caso de la Universidad Politécnica de Valencia

Directory of Open Access Journals (Sweden)

Alejandra Boni

2012-01-01

Full Text Available El objetivo de este artículo es analizar cómo dos iniciativas (una formal, la creación de un currículum inspirado en la Educación para el Desarrollo y un espacio informal, el colectivo estudiantil Mueve, desarrolladas en la Universidad Politécnica de Valencia, pueden haber contribuido a la adquisición de habilidades cosmopolitas entre la comunidad estudiantil. Para ello, realizaremos primero un recorrido conceptual por distintos autores que han tratado la cuestión del cosmopolitismo y que, en su mayoría, se encuentran enmarcados en el enfoque de capacidades para el desarrollo humano. Tras ello, analizaremos y discutiremos los resultados de 12 entrevistas en profundidad realizadas a estudiantes que han participado en los dos espacios anteriormente comentados.

ESTUDIO cycEVA: CASOS Y CONTROLES PARA LA ESTIMACIÓN DE LA EFECTIVIDAD DE LA VACUNA ANTIGRIPAL EN ESPAÑA, 2008-2013

Directory of Open Access Journals (Sweden)

Silvia Jiménez-Jorge

2014-01-01

Full Text Available Fundamentos: Desde 2008-09 la efectividad de la vacuna (EV antigripal en España se estima con el estudio de casos y controles para la evaluación de la EV antigripal (cycEVA, componente español de la red europea (Influenza-Monitoring Vaccine Effectiveness (I-MOVE. El objetivo es describir la evolución del estudio cycEVA durante las cinco temporadas del período 2008/09– 2012/13. Métodos: Se analizaron los siguientes indicadores: 1 participación de los médicos/pediatras centinela (MP; 2 población y periodo de estudio, 3 calidad de los datos y 4 difusión de los resultados mediantes publicaciones. Se calculó el porcentaje anual de cambio constante de los indicadores analizándose su tendencia mediante el test de Cochran-Armitage. Resultados: El número de MP participantes aumentó de 164 en 2008-09 hasta 246 en ediciones posteriores. El porcentaje de médicos que reclutaron al menos un paciente experimentó un cambio anual significativo (PCA del 15,33%. El porcentaje de pacientes reclutados incluidos en el análisis aumen- tó del 77% en 2008-09 a más del 95% en las siguientes ediciones (PCA=5,91%. El porcentaje de casos y controles participantes en cycEVA sobre el total de pacientes que contribuyeron al estudio europeo I-MOVE osciló entre el 23% en la edición piloto y 30% en la temporada 2011-12. Los resultados finales se difundieron en revistas científicas con un factor de impacto situado en el cuartil 2 y en 2010-11 y 2011-12 se publicaron resultados preliminares en revistas con un factor de impacto situado en el cuartil 1 (97 citas. Conclusiones: La experiencia del estudio cycEVA se reflejó en una mejora en la oportunidad e impacto de sus resultados, cruciales para orientar las recomendaciones anuales de vacunación antigripal.

Meninges control tangential migration of hem-derived Cajal-Retzius cells via CXCL12/CXCR4 signaling.

Science.gov (United States)

Borrell, Víctor; Marín, Oscar

2006-10-01

Cajal-Retzius cells are critical in the development of the cerebral cortex, but little is known about the mechanisms controlling their development. Three focal sources of Cajal-Retzius cells have been identified in mice-the cortical hem, the ventral pallium and the septum-from where they migrate tangentially to populate the cortical surface. Using a variety of tissue culture assays and in vivo manipulations, we demonstrate that the tangential migration of cortical hem-derived Cajal-Retzius cells is controlled by the meninges. We show that the meningeal membranes are a necessary and sufficient substrate for the tangential migration of Cajal-Retzius cells. We also show that the chemokine CXCL12 secreted by the meninges enhances the dispersion of Cajal-Retzius cells along the cortical surface, while retaining them within the marginal zone in a CXCR4-dependent manner. Thus, the meningeal membranes are fundamental in the development of Cajal-Retzius cells and, hence, in the normal development of the cerebral cortex.

Conocimiento de la enfermera en la atención a usuario con pre-eclampsia y eclampsia.

OpenAIRE

González Heras, NP.; Ballardo Mendoza, M.G.; Domínguez Luna, IF.; Magaña Ramírez, S.; Molina Heras, OA.; Uriarte Ontiveros, S.

2008-01-01

Introducción La preeclampsia-eclampsia continúa siendo una de las principales causas de morbilidad y mortalidad perinatal en todo el mundo. En México ha sido la primera causa de muerte materna en los últimos 20 años a pesar de los avances en calidad y cantidad de control prenatal, de la atención del parto y puerperio. (1-2). Objetivo Identificar el nivel de conocimiento que tiene el personal de enfermería del área de Tococirugía y Ginecoobstetricia en la atención a...

La noción de violencia en la ficción televisiva: la interpretación infantil

Directory of Open Access Journals (Sweden)

Sue Aran Ramspott

2013-03-01

Full Text Available En el presente trabajo se analiza la interpretación de los espectadores infantiles ante la presencia de violencia en la programación televisiva dirigida a la infancia. Su justificación se enmarca en aquellas investigaciones que consideran necesario la realización de más estudios teóricos y empíricos sobre la conceptualización de la violencia, y sobre cuánta violencia se legitima y cuáles son los mecanismos con los que se construye dicha legitimación. El objetivo que se persigue es ofrecer una noción de violencia televisiva según la interpretación de los telespectadores infantiles que tenga en cuenta dichos mecanismos. La metodología utilizada se basa en el análisis de contenido y del discurso de las entrevistas en profundidad efectuadas a dieciséis niños y niñas menores de 12 años, después de mostrarles dos secuencias de la programación televisiva con tipos y formalización diversa de violencia de ficción. Los resultados, además de ofrecer un mapa conceptual sobre las respuestas, indican cómo niños y niñas definen y diferencian distintos tipos de violencia. También se puede constatar cómo su proceso de recepción está enmarcado por una historia cultural y por unas prácticas concretas de lectura y consumo, en las que los aspectos narrativos contextuales tienen un gran protagonismo en la interpretación infantil de la violencia. Así, los resultados de la investigación señalan cómo niños y niñas dan a la violencia una significación de carácter no restringido.

Evidencias espectroscópicas de RMN de ¹H y 13C en la formación inusual de un "carbonilo inorgánico", derivado de la lactona costunólida

OpenAIRE

Díaz, Eduardo; Barrios, Héctor; Fuentes, Aydeé; Corona, David; Guzmán, Ángel

2002-01-01

El uso de la RMN de ¹H y 13C permitió determinar la estructura inusual de un "carbonilo inorgánico" derivado de la lactona dehidrocostus. 1H and 13C NMR of an unusual "inorganic carbonyl" derived from costunolide lactone are described.

Growth of self-textured Ga3+-substituted Li7La3Zr2O12 ceramics by solid state reaction and their significant enhancement in ionic conductivity

Science.gov (United States)

Qin, Shiying; Zhu, Xiaohong; Jiang, Yue; Ling, Ming'en; Hu, Zhiwei; Zhu, Jiliang

2018-03-01

A highly self-textured Ga2O3-substituted Li7La3Zr2O12 (LLZO-Ga) solid electrolyte with a nominal composition of Li6.55Ga0.15La3Zr2O12 is obtained by a simple and low-cost solid-state reaction technique, requiring no seed crystals to achieve grain orientation. The as-prepared self-textured LLZO-Ga shows a strong (420) preferred orientation with a high Lotgering factor of 0.91. Coherently, a terrace-shaped microstructure consisting of many parallel layers, indicating a two-dimensional-like growth mode, is clearly observed in the self-textured sample. As a result, the highly self-textured garnet-type lithium-ion conducting solid electrolyte of LLZO-Ga exhibits an extremely high ionic conductivity, reaching a state-of-the-art level of 2.06 × 10-3 S cm-1 at room temperature (25 °C) and thus shedding light on an important strategy for improving the structure and ionic conductivity of solid electrolytes.

Perfil del comportamiento sexual en adolescentes mexicanos de 12 a 19 años de edad: resultados de la ENSA 2000 Profile of sexual behavior in 12 to 19 year-old Mexican adolescents: results of ENSA 2000

Directory of Open Access Journals (Sweden)

Carlos González-Garza

2005-06-01

Full Text Available OBJETIVO: Describir las características del comportamiento sexual de los adolescentes mexicanos, su grado de conocimiento sobre anticoncepción, las variables que se relacionan con la utilización de anticonceptivos en la primera relación sexual y las que se asocian con el embarazo. MATERIAL Y MÉTODOS: Se analizó la base de datos de adolescentes de la Encuesta Nacional de Salud 2000, realizada en septiembre de 1999 a marzo de 2000, la cual tuvo un diseño complejo al ser probabilístico, polietápico, estratificado y por conglomerados. La muestra incluyó a adolescentes de entre 12 a 19 años de edad (n=15 241. Se hizo un análisis descriptivo, se aplicó la prueba ji cuadrada (Wald para evaluar diferencias de proporciones, y se construyeron dos modelos de regresión logística para obtener razones de momios. RESULTADOS: El 69.2% de los adolescentes refirió conocer al menos un método de control de la fecundidad. El 16.4% mencionó haber tenido relaciones sexuales, y los hombres iniciaron la actividad sexual antes que las mujeres; es importante mencionar que tan sólo 37% de los adolescentes usaron algún método anticonceptivo en la primera relación sexual. El análisis de regresión logística mostró que los adolescentes del sexo masculino, los de mayor escolaridad, quienes poseían información de algún método anticonceptivo y aquellos que inician esta actividad a una edad mayor tuvieron más probabilidad de usar anticonceptivos en su primera relación sexual. El 55.7% de las mujeres que mencionaron haber iniciado actividad sexual han estado embarazadas. El embarazo en las adolescentes se asoció significativamente con un nivel bajo de escolaridad, con iniciar su vida sexual a edades tempranas y con el hecho de haber estado alguna vez unidas. Conclusiones. En general, la población adolescente que ha tenido relaciones sexuales no utilizó métodos anticonceptivos durante su primera relación, lo cual incrementa la posibilidad de

Decay of 143La

International Nuclear Information System (INIS)

Blachot, J.; Dousson, S.; Monnand, E.; Schussler, F.

1976-01-01

The decay of 143 La has been investigated. Sources have been obtained from 2 isotope separators (ISERE, OSIRIS). 12 gamma rays, with the most intense at 620keV representing only 1.4% of decay, have been attributed to the 143 La decay. A level scheme has been found and compared with the one deduced from (d,p) and (n,γ) reactions on 142 Ce [fr

Synthesis and anticandidal activity of some imidazopyridine derivatives.

Science.gov (United States)

Kaplancikli, Zafer Asim; Turan-Zitouni, Gülhan; Ozdemir, Ahmet; Revial, Gilbert

2008-12-01

New hydrazide derivatives of imidazo[1,2-a]pyridine have been synthesized and evaluated for anticandidal activity. The reaction of imidazo[1,2-a]pyridine-2-carboxylic acid hydrazides with various benzaldehydes gave N-(benzylidene)imidazo[ 1,2-a]pyridine-2-carboxylic acid hydrazide derivatives. Their anticandidal activities against Candida albicans and Candida glabrata (isolates obtained from Osmangazi University, Faculty of Medicine, Eskisehir, Turkey), Candida albicans (ATCC 90028), Candida utilis (NRLL Y-900), Candida tropicalis (NRLL Y-12968), Candida krusei (NRLL Y-7179), Candida zeylanoides (NRLL Y-1774), and Candida parapsilosis (NRLL Y-12696) were investigated.