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Sample records for platform resist eh27

  1. Modified EAS Tag Used as a Resistive Sensor Platform

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    Henrik Andersson

    2012-11-01

    Full Text Available In this article, a modified design of an RF Radio Frequency Electronic Article Surveillance (EAS tag, used as a sensor platform, is manufactured and characterized. EAS tags are passive devices consisting of a capacitor and coil, tuned to a resonance frequency readable by the detector equipment, in this case 8.2 MHz. They were originally used to detect whether merchandise was being moved through the detection gates at shop exits, in which case an alarm was triggered. If the capacitance is divided in two and a resistive sensor device inserted in between, the resonant Inductor-Capacitor (LC circuit becomes an Inductor-Capacitor-Capacitor-Resistor LCCR circuit and can be used as a sensor tag. A high sensor resistance means that one capacitor is decoupled, leading to one resonance frequency, while a low resistance will couple both capacitances into the circuit, resulting in a lower resonance frequency. Different types of resistive sensors exist that are able to detect properties such as pressure, moisture, light and temperature. The tag is manufactured in Aluminum foil on a polyetylentereftalat (PET substrate, resulting in a cost effective RF-platform for various resistive sensors. Two types of tags are designed and manufactured, one with parallel plate capacitors and the other with interdigital capacitors. To test the tags, a resistive tilt sensor is mounted and the tags are characterized using a network analyzer. It is shown that for high resistance, the tags have a resonance frequency of morethan 10 MHz while for low values the frequency approaches 8.2 MHz.

  2. Modelling for Uncertainties in Resistance for Jacket Platforms in Malaysia

    Directory of Open Access Journals (Sweden)

    V.J. Kurian

    2013-01-01

    Full Text Available Structural design strength is based on characteristic values of basic random variables of resistance. The behavior of these variables of strength may vary in such a way that they become unsafe during any time of their design life. The data for this study was collected from an ISO certified fabrication yard in Malaysia and was used to make statistical models. The collected data is based on jackets which were under construction at the yard. Statistical analysis of the data was performed, taking into account the mean, coefficient of variation and bias values. Initially basic random variables were analyzed and after their statistical parameters were found, the basic stresses were simulated based on ISO 19902 code equations. Finally recommendations are made for the statistical characteristics of the random variables to be used in this region for the reliability analysis for tubular members and joints for ultimate limit state design of jacket platforms in Malaysia.

  3. Novel diamantane polymer platform for enhanced etch resistance

    Science.gov (United States)

    Padmanaban, Munirathna; Chakrapani, Srinivasan; Lin, Guanyang; Kudo, Takanori; Parthasarathy, Deepa; Rahman, Dalil; Anyadiegwu, Clement; Antonio, Charito; Dammel, Ralph R.; Liu, Shenggao; Lam, Frederick; Waitz, Anthony; Yamagchi, Masao; Maehara, Takayuki

    2007-03-01

    The dominant current 193 nm photoresist platform is based on adamantane derivatives. This paper reports on the use of derivatives of diamantane, the next higher homolog of adamantane, in the diamondoid series, as monomers in photoresists. Due to their low Ohnishi number and incremental structural parameter (ISP), such molecules are expected to enhance dry etch stability when incorporated into polymers for resist applications. Starting from the diamantane parent, cleavable and non-cleavable acrylate/methacrylate derivatives of diamantane were obtained using similar chemical steps as for adamantane derivatization. This paper reports on the lithographic and etch performance obtained with a number of diamantane-containing monomers, such as 9-hydroxy-4-diamantyl methacrylate (HDiMA), 2-ethyl-2- diamantyl methacrylate (EDiMA), and 2-methyl-2-diamantyl methacrylate (MDiMA). The etch advantage, dry and wet lithographic performance of some of the polymers obtained from these diamantane-containing polymers are discussed.

  4. EUV resist outgassing analysis for the new platform resists at EIDEC

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    Shiobara, Eishi; Kikuchi, Yukiko; Mikami, Shinji; Sasami, Takeshi; Kamizono, Takashi; Minegishi, Shinya; Kimoto, Takakazu; Fujimori, Toru; Watanabe, Takeo; Harada, Tetsuo; Kinoshita, Hiroo; Tanaka, Satoshi

    2016-03-01

    The suppression of outgassing from the EUV resist is one of the significant challenges, which has to be addressed for realizing EUV lithography (EUVL). The outgassing might be the main contributor involved in the contamination of the mirror optics in scanners. This may result in reflectivity losses. The pragmatic outgassing test that utilizes the witness sample (WS) was used as a general method to quantify the outgassing level for commercially available chemically amplified resists (CAR). There are two types of contaminations. The first type of contamination involves a cleanable contamination that mainly comprises hydrocarbons that can be removed by the hydrogen radical cleaning. Another type of contamination includes the noncleanable contamination that remains on the WS even after hydrogen radical cleaning. Several outgas qualification results were evaluated at the EIDEC [1, 2]. The data indicated that contaminations by the CAR mainly comprised the cleanable contaminations. The data also indicated that there were almost negligible noncleanable contaminations from the CAR. EUV resist communities accelerate the development of high sensitivity resists to compensate the low power of the EUV source. Nonchemically amplified resist (nonCAR) with a new platform is a candidate for high sensitivity resists. The nonCAR includes some types of metal elements with high absorbance for EUV light. There is very limited research on the outgassing characteristics of the nonCAR. In this study, we considered an EUV exposure process in the actual EUV scanner and EUV resists were exposed in a hydrogen environment. A potential risk could result from the reaction of the hydrogen radicals generated by the EUV light with the metal elements in the nonCAR and the metal hydride outgases from the resist. This would result in a noncleanable contamination on the EUV mirror [3]. The knowledge with respect to outgassing from an organic metal complex is insufficient even in a vacuum condition. Hence

  5. A wireless platform for in vivo measurement of resistance properties of the gastrointestinal tract.

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    Natali, C Di; Beccani, M; Obstein, K L; Valdastri, P

    2014-07-01

    Active locomotion of wireless capsule endoscopes has the potential to improve the diagnostic yield of this painless technique for the diagnosis of gastrointestinal tract disease. In order to design effective locomotion mechanisms, a quantitative measure of the propelling force required to effectively move a capsule inside the gastrointestinal tract is necessary. In this study, we introduce a novel wireless platform that is able to measure the force opposing capsule motion, without perturbing the physiologic conditions with physical connections to the outside of the gastrointestinal tract. The platform takes advantage of a wireless capsule that is magnetically coupled with an external permanent magnet. A secondary contribution of this manuscript is to present a real-time method to estimate the axial magnetic force acting on a wireless capsule manipulated by an external magnetic field. In addition to the intermagnetic force, the platform provides real-time measurements of the capsule position, velocity, and acceleration. The platform was assessed with benchtop trials within a workspace that extends 15 cm from each side of the external permanent magnet, showing average error in estimating the force and the position of less than 0.1 N and 10 mm, respectively. The platform was also able to estimate the dynamic behavior of a known resistant force with an error of 5.45%. Finally, an in vivo experiment on a porcine colon model validated the feasibility of measuring the resistant force in opposition to magnetic propulsion of a wireless capsule.

  6. Reliability-Based Load and Resistance Factors Design for Offshore Jacket Platforms in the Bohai Bay: Calibration on Design Factors

    Institute of Scientific and Technical Information of China (English)

    JIN Wei-liang; HU Qi-zhong; SHEN Zhao-wei; SHI Zhong-min

    2009-01-01

    For the fulfillment of the probability-based structural design for the offshore jacket platforms in the Bohai Bay, the design factors of loads, resistance and load combinations are much necessary to be calibrated according to the proposed target reliability index. Firstly, the limit states function for the offshore jacket platforms is introduced. Then, four ap-proaches to calibrate the factors of load and resistance are presented and compared. Afterwards, the methods to calibrate the load combination factors are developed. Finally, the factors of load, resistance and load combination for the offshore jacket platforms in the Bohai Bay are calibrated and the corresponding design formulae are recommended. The results are proved to be rational in practice, and also illustrate that the proposed target reliability index for offshore jacket platforms in the Bohai Bay is also appropriate.

  7. Calibration of LRFD Format for Steel Jacket Offshore Platforms in China Offshore Area (1):Statistical Parameters of Loads and Resistances

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    The statistical characteristics and parameters of loads and resistances are systematically studied for the development of probabilistic limit state design method for steel jacket offshore platforms in the China offshore area. The mean value, standard variance and distribution pattern of resistances and loads in different base periods are presented. The statistical parameters of structural member resistance, self-weight, deck live load, and environmental loads such as wind, wave, current and ice, which are drawn on a large amount of observation data of offshore environmental factors, and the design data of platforms in China Bohai Sea form the data set, providing a necessary basis for the calibration of load and resistance factors to realize the reliability-based design of jacket platform structures.

  8. Calibration of LRFD Format for Steel Jacket Offshore Platform in China Offshore Area (2): Load, Resistance and Load Combination Factors

    Institute of Scientific and Technical Information of China (English)

    ZHOU Dao-cheng; DUAN Zhong-dong; OU Jin-ping

    2006-01-01

    Adopting the load and resistance factor design format, the design method for steel jacket platform structures is developed. Firstly, the limit state equations and design format for steel jacket platform structures are introduced. Then, the ratio of live load effect to dead load effect is estimated. The target reliabilities for design of offshore structures in China offshore area are calibrated by past practice in API RP2A-WSD code. The load and resistance factors are optimized by minimizing the difference within the target reliability and the resulting reliability over the range of load effect ratios. Considering the concurrence of different loads, load combination factors are obtained through an optimization process, and the relation between the load combination factor and load correlation coefficient is established. Finally, the design formulae for steel jacket structures in China offshore area are recommended.

  9. A solvent resistant lab-on-chip platform for radiochemistry applications.

    Science.gov (United States)

    Rensch, Christian; Lindner, Simon; Salvamoser, Ruben; Leidner, Stephanie; Böld, Christoph; Samper, Victor; Taylor, David; Baller, Marko; Riese, Stefan; Bartenstein, Peter; Wängler, Carmen; Wängler, Björn

    2014-07-21

    The application of microfluidics to the synthesis of Positron Emission Tomography (PET) tracers has been explored for more than a decade. Microfluidic benefits such as superior temperature control have been successfully applied to PET tracer synthesis. However, the design of a compact microfluidic platform capable of executing a complete PET tracer synthesis workflow while maintaining prospects for commercialization remains a significant challenge. This study uses an integral system design approach to tackle commercialization challenges such as the material to process compatibility with a path towards cost effective lab-on-chip mass manufacturing from the start. It integrates all functional elements required for a simple PET tracer synthesis into one compact radiochemistry platform. For the lab-on-chip this includes the integration of on-chip valves, on-chip solid phase extraction (SPE), on-chip reactors and a reversible fluid interface while maintaining compatibility with all process chemicals, temperatures and chip mass manufacturing techniques. For the radiochemistry device it includes an automated chip-machine interface enabling one-move connection of all valve actuators and fluid connectors. A vial-based reagent supply as well as methods to transfer reagents efficiently from the vials to the chip has been integrated. After validation of all those functional elements, the microfluidic platform was exemplarily employed for the automated synthesis of a Gastrin-releasing peptide receptor (GRP-R) binding the PEGylated Bombesin BN(7-14)-derivative ([(18)F]PESIN) based PET tracer.

  10. Understanding the structural mechanisms of antibiotic resistance sets the platform for new discovery.

    Science.gov (United States)

    Reeve, Stephanie M; Lombardo, Michael N; Anderson, Amy C

    2015-01-01

    Understanding the structural basis of antibacterial resistance may enable rational design principles that avoid and subvert that resistance, thus leading to the discovery of more effective antibiotics. In this review, we explore the use of crystal structures to guide new discovery of antibiotics that are effective against resistant organisms. Structures of efflux pumps bound to substrates and inhibitors have aided the design of compounds with lower affinity for the pump or inhibitors that more effectively block the pump. Structures of β-lactamase enzymes have revealed the mechanisms of action toward key carbapenems and structures of gyrase have aided the design of compounds that are less susceptible to point mutations.

  11. Understanding the basis of antibiotic resistance: a platform for drug discovery.

    Science.gov (United States)

    Piddock, Laura J V

    2014-11-01

    There are numerous genes in Salmonella enterica serovar Typhimurium that can confer resistance to fluoroquinolone antibiotics, including those that encode topoisomerase proteins, the primary targets of this class of drugs. However, resistance is often multifactorial in clinical isolates and it is not uncommon to also detect mutations in genes that affect the expression of proteins involved in permeability and multi-drug efflux. The latter mechanism, mediated by tripartite efflux systems, such as that formed by the AcrAB-TolC system, confers inherent resistance to many antibiotics, detergents and biocides. Genetic inactivation of efflux genes gives multi-drug hyper-susceptibility, and in the absence of an intact AcrAB-TolC system some chromosomal and transmissible antibiotic resistance genes no longer confer clinically relevant levels of resistance. Furthermore, a functional multi-drug resistance efflux pump, such as AcrAB-TolC, is required for virulence and the ability to form a biofilm. In part, this is due to altered expression of virulence and biofilm genes being sensitive to efflux status. Efflux pump expression can be increased, usually due to mutations in regulatory genes, and this confers resistance to clinically useful drugs such as fluoroquinolones and β-lactams. Here, I discuss some of the work my team has carried out characterizing the mechanisms of antibiotic resistance in Salmonella enterica serovar Typhimurium from the late 1980s to 2014. A video of this Prize Lecture, presented at the Society for General Microbiology Annual Conference 2014, can be viewed via this link: https://www.youtube.com/watch?v=MCRumMV99Yw. © 2014 The Authors.

  12. A Bioengineered Three-Dimensional Cell Culture Platform Integrated with Microfluidics To Address Antimicrobial Resistance in Tuberculosis.

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    Bielecka, Magdalena K; Tezera, Liku B; Zmijan, Robert; Drobniewski, Francis; Zhang, Xunli; Jayasinghe, Suwan; Elkington, Paul

    2017-02-07

    Antimicrobial resistance presents one of the most significant threats to human health, with the emergence of totally drug-resistant organisms. We have combined bioengineering, genetically modified bacteria, longitudinal readouts, and fluidics to develop a transformative platform to address the drug development bottleneck, utilizing Mycobacterium tuberculosis as the model organism. We generated microspheres incorporating virulent reporter bacilli, primary human cells, and an extracellular matrix by using bioelectrospray methodology. Granulomas form within the three-dimensional matrix, and mycobacterial stress genes are upregulated. Pyrazinamide, a vital first-line antibiotic for treating human tuberculosis, kills M. tuberculosis in a three-dimensional culture but not in a standard two-dimensional culture or Middlebrook 7H9 broth, demonstrating that antibiotic sensitivity within microspheres reflects conditions in patients. We then performed pharmacokinetic modeling by combining the microsphere system with a microfluidic plate and demonstrated that we can model the effect of dynamic antibiotic concentrations on mycobacterial killing. The microsphere system is highly tractable, permitting variation of cell content, the extracellular matrix, sphere size, the infectious dose, and the surrounding medium with the potential to address a wide array of human infections and the threat of antimicrobial resistance.

  13. A Bioengineered Three-Dimensional Cell Culture Platform Integrated with Microfluidics To Address Antimicrobial Resistance in Tuberculosis

    Directory of Open Access Journals (Sweden)

    Magdalena K. Bielecka

    2017-02-01

    Full Text Available Antimicrobial resistance presents one of the most significant threats to human health, with the emergence of totally drug-resistant organisms. We have combined bioengineering, genetically modified bacteria, longitudinal readouts, and fluidics to develop a transformative platform to address the drug development bottleneck, utilizing Mycobacterium tuberculosis as the model organism. We generated microspheres incorporating virulent reporter bacilli, primary human cells, and an extracellular matrix by using bioelectrospray methodology. Granulomas form within the three-dimensional matrix, and mycobacterial stress genes are upregulated. Pyrazinamide, a vital first-line antibiotic for treating human tuberculosis, kills M. tuberculosis in a three-dimensional culture but not in a standard two-dimensional culture or Middlebrook 7H9 broth, demonstrating that antibiotic sensitivity within microspheres reflects conditions in patients. We then performed pharmacokinetic modeling by combining the microsphere system with a microfluidic plate and demonstrated that we can model the effect of dynamic antibiotic concentrations on mycobacterial killing. The microsphere system is highly tractable, permitting variation of cell content, the extracellular matrix, sphere size, the infectious dose, and the surrounding medium with the potential to address a wide array of human infections and the threat of antimicrobial resistance.

  14. A Bioengineered Three-Dimensional Cell Culture Platform Integrated with Microfluidics To Address Antimicrobial Resistance in Tuberculosis

    Science.gov (United States)

    Bielecka, Magdalena K.; Tezera, Liku B.; Zmijan, Robert; Drobniewski, Francis; Zhang, Xunli; Jayasinghe, Suwan

    2017-01-01

    ABSTRACT Antimicrobial resistance presents one of the most significant threats to human health, with the emergence of totally drug-resistant organisms. We have combined bioengineering, genetically modified bacteria, longitudinal readouts, and fluidics to develop a transformative platform to address the drug development bottleneck, utilizing Mycobacterium tuberculosis as the model organism. We generated microspheres incorporating virulent reporter bacilli, primary human cells, and an extracellular matrix by using bioelectrospray methodology. Granulomas form within the three-dimensional matrix, and mycobacterial stress genes are upregulated. Pyrazinamide, a vital first-line antibiotic for treating human tuberculosis, kills M. tuberculosis in a three-dimensional culture but not in a standard two-dimensional culture or Middlebrook 7H9 broth, demonstrating that antibiotic sensitivity within microspheres reflects conditions in patients. We then performed pharmacokinetic modeling by combining the microsphere system with a microfluidic plate and demonstrated that we can model the effect of dynamic antibiotic concentrations on mycobacterial killing. The microsphere system is highly tractable, permitting variation of cell content, the extracellular matrix, sphere size, the infectious dose, and the surrounding medium with the potential to address a wide array of human infections and the threat of antimicrobial resistance. PMID:28174307

  15. Ability of High-Resolution Resistivity Tomography to Detect Fault and Fracture Zones: Application to the Tournemire Experimental Platform, France

    Science.gov (United States)

    Gélis, C.; Noble, M.; Cabrera, J.; Penz, S.; Chauris, H.; Cushing, E. M.

    2016-02-01

    The Experimental Platform of Tournemire (Aveyron, France) developed by IRSN (French Institute for Radiological Protection and Nuclear Safety) is composed of a tunnel excavated in an argillite formation belonging to a limestone-argillite-limestone subhorizontal sedimentary sequence. Subvertical secondary fault zones were intercepted in argillite using drifts and boreholes in the tunnel excavated at a depth of about 250 m located under the Larzac Plateau. A 2D 2.5 km baseline large-scale electrical resistivity survey conducted in 2007 allowed detecting in the upper limestones several significantly low electrical resistivity subvertical zones (G élis et al. Appl Geophys 167(11): 1405-1418, 2010). One of these discontinuities is consistent with the extension towards the surface of the secondary fault zones identified in the argillite formation from the tunnel. In an attempt to better characterize this zone, IRSN and MINES ParisTech conducted a high-resolution electrical resistivity survey located transversally to the fault and fracture zones. A 760-m-long profile was acquired using two array geometries and take-outs of 2, 4 and 8 m, requiring several roll-alongs. These data were first inverted independently for each take-out and then using all take-outs together for a given array geometry. Different inverted 2D electrical resistivity models display the same global features with high (higher than 5000 Ωm) to low (lower than 100 Ωm) electrical resistivity zones. These electrical resistivity models are finally compared with a geological cross-section based on independent data. The subvertical conductive zones are in agreement with the fault and fracture locations inferred from the geological cross-section. Moreover, the top of a more conductive zone, below a high electrical conductive zone and between two subvertical fault zones, is located in a more sandy and argillaceous layer. This conductive zone is interpreted as the presence of a more scattered fracture zone

  16. Quantamatrix Multiplexed Assay Platform system for direct detection of bacteria and antibiotic resistance determinants in positive blood culture bottles.

    Science.gov (United States)

    Wang, H Y; Uh, Y; Kim, S; Lee, H

    2017-05-01

    Rapid and accurate identification of the causative pathogens of bloodstream infections (BSIs) is crucial for initiating appropriate antimicrobial therapy, which decreases the related morbidity and mortality rates. The aim of this study was to evaluate the usefulness of a newly developed multiplexed, bead-based bioassay system, the Quantamatrix Multiplexed Assay Platform (QMAP) system, obtained directly from blood culture bottles, to simultaneously detect the presence of bacteria and identify the genes for antibiotic resistance. The QMAP system was used to evaluate 619 blood culture bottles from patients with BSIs and to compare the results of conventional culture methods. Using conventional bacterial cultures as the reference standard, the sensitivity, specificity, positive predictive value, and negative predictive value of the QMAP system for detection of bacterial pathogens in positive blood culture (PBC) samples were 99.8% (n=592, 95% CI 0.9852-1.000, p system for identification of the genes for antibiotic resistance were 99.4% (n=158, 95% CI 0.9617-0.9999, p system takes about 3 hr, while culture methods can take 48-72 hr. Therefore, analysis using the QMAP system is rapid and reliable for characterizing causative pathogens in BSIs. Copyright © 2016 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

  17. Whole animal automated platform for drug discovery against multi-drug resistant Staphylococcus aureus.

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    Rajamuthiah, Rajmohan; Fuchs, Beth Burgwyn; Jayamani, Elamparithi; Kim, Younghoon; Larkins-Ford, Jonah; Conery, Annie; Ausubel, Frederick M; Mylonakis, Eleftherios

    2014-01-01

    Staphylococcus aureus, the leading cause of hospital-acquired infections in the United States, is also pathogenic to the model nematode Caenorhabditis elegans. The C. elegans-S. aureus infection model was previously carried out on solid agar plates where the bacteriovorous C. elegans feeds on a lawn of S. aureus. However, agar-based assays are not amenable to large scale screens for antibacterial compounds. We have developed a high throughput liquid screening assay that uses robotic instrumentation to dispense a precise amount of methicillin resistant S. aureus (MRSA) and worms in 384-well assay plates, followed by automated microscopy and image analysis. In validation of the liquid assay, an MRSA cell wall defective mutant, MW2ΔtarO, which is attenuated for killing in the agar-based assay, was found to be less virulent in the liquid assay. This robust assay with a Z'-factor consistently greater than 0.5 was utilized to screen the Biomol 4 compound library consisting of 640 small molecules with well characterized bioactivities. As proof of principle, 27 of the 30 clinically used antibiotics present in the library conferred increased C. elegans survival and were identified as hits in the screen. Surprisingly, the antihelminthic drug closantel was also identified as a hit in the screen. In further studies, we confirmed the anti-staphylococcal activity of closantel against vancomycin-resistant S. aureus isolates and other Gram-positive bacteria. The liquid C. elegans-S. aureus assay described here allows screening for anti-staphylococcal compounds that are not toxic to the host.

  18. Whole animal automated platform for drug discovery against multi-drug resistant Staphylococcus aureus.

    Directory of Open Access Journals (Sweden)

    Rajmohan Rajamuthiah

    Full Text Available Staphylococcus aureus, the leading cause of hospital-acquired infections in the United States, is also pathogenic to the model nematode Caenorhabditis elegans. The C. elegans-S. aureus infection model was previously carried out on solid agar plates where the bacteriovorous C. elegans feeds on a lawn of S. aureus. However, agar-based assays are not amenable to large scale screens for antibacterial compounds. We have developed a high throughput liquid screening assay that uses robotic instrumentation to dispense a precise amount of methicillin resistant S. aureus (MRSA and worms in 384-well assay plates, followed by automated microscopy and image analysis. In validation of the liquid assay, an MRSA cell wall defective mutant, MW2ΔtarO, which is attenuated for killing in the agar-based assay, was found to be less virulent in the liquid assay. This robust assay with a Z'-factor consistently greater than 0.5 was utilized to screen the Biomol 4 compound library consisting of 640 small molecules with well characterized bioactivities. As proof of principle, 27 of the 30 clinically used antibiotics present in the library conferred increased C. elegans survival and were identified as hits in the screen. Surprisingly, the antihelminthic drug closantel was also identified as a hit in the screen. In further studies, we confirmed the anti-staphylococcal activity of closantel against vancomycin-resistant S. aureus isolates and other Gram-positive bacteria. The liquid C. elegans-S. aureus assay described here allows screening for anti-staphylococcal compounds that are not toxic to the host.

  19. Comparative Efficacy of Progressive Resistance Exercise and Biomechanical Ankle Platform System on Functional Indices of Children with Cerebral Palsy.

    Science.gov (United States)

    Adepoju, Faderera; Hamzat, Talhatu; Akinyinka, Olusegun

    2017-01-01

    Progressive Resistance Exercise (PRE) and Biomechanical Ankle Platform System (BAPS) are two of the protocols available in managing children with Cerebral Palsy (CP). The comparative effects of these modalities on selected functional indices of ambulatory type CP were the focus of this study. Twenty-eight children with hemiplegic or diplegic CP receiving care at a tertiary health facility in Ibadan were consecutively recruited. They were systematically assigned into two intervention groups. Namely PRE, BAPS. Both groups received intervention twice weekly for 16 weeks. At baseline, 8 and 16 weeks of intervention balance and functional mobility were assessed using Berg Balance Scale (BBS) and modified timed-up-and-go test (TUG) respectively. Chi-square, Fisher's Exact tests, One way and repeated measures ANOVA were carried out. Level of significance (p) was set at 0.05. There were significant differences in the functional indices of participants in the BAPS group at the end of the intervention (p 0.05). All outcome measures increased in both groups from baseline to the end of the intervention period. The two intervention protocols demonstrated improvements in the areas assessed. Comparatively, both PRE and BAPS could be used to promote function in CP.

  20. Reliability-Based Load and Resistance Factors Design for Offshore Jacket Platforms in the Bohai Bay:Calibration on Target Reliability Index

    Institute of Scientific and Technical Information of China (English)

    JIN Wei-liang; HU Qi-zhong; SHEN Zhao-wei; SHI Zhong-min

    2009-01-01

    The target reliability index has been effectively used as the best solution to deal with the relationship between the structural safety and the optimal economy in any structural design.However,the target reliability index for offshore jacket platforms based on different sea areas in China has never been calibrated.This paper presents an approach for its calibration,and suggests many kinds of associated load cases.The uncertainties of loads and structural resistance are mainly investigated.The target reliability index for structural components,tubular joints and piles of offshore jacket platforms are discussed respectively in detail.Finally,through the calibrated results from the offshore jacket platforms of QK18-1,JZ20-2,SZ36-1 and BZ28-1 in the Bohai Bay,it is proposed to adopt 2.8 as the target reliability index of offshore jacket platforms in the Bohai Bay for a 25-year design period.The results provide significant reference for the design of offshore jacket platforms.

  1. Potential of Electrical Resistivity Tomography to Detect Fault Zones in Limestone and Argillaceous Formations in the Experimental Platform of Tournemire, France

    Science.gov (United States)

    Gélis, C.; Revil, A.; Cushing, M. E.; Jougnot, D.; Lemeille, F.; Cabrera, J.; de Hoyos, A.; Rocher, M.

    2010-11-01

    The Experimental platform of Tournemire (Aveyron, France) developed by IRSN (French Institute for Radiological Protection and Nuclear Safety) is located in a tunnel excavated in a clay-rock formation interbedded between two limestone formations. A well-identified regional fault crosscuts this subhorizontal sedimentary succession, and a subvertical secondary fault zone is intercepted in the clay-rock by drifts and boreholes in the tunnel at a depth of about 250 m. A 2D electrical resistivity survey was carried out along a 2.5 km baseline, and a takeout of 40 m was used to assess the potential of this method to detect faults from the ground surface. In the 300 m-thick zone investigated by the survey, electrical resistivity images reveal several subvertical low-resistivity discontinuities. One of these discontinuities corresponds to the position of the Cernon fault, a major regional fault. One of the subvertical conductive discontinuities crossing the upper limestone formation is consistent with the prolongation towards the ground surface of the secondary fault zone identified in the clay-rock formation from the tunnel. Moreover, this secondary fault zone corresponds to the upward prolongation of a subvertical fault identified in the lower limestone using a 3D high-resolution seismic reflection survey. This type of large-scale electrical resistivity survey is therefore a useful tool for identifying faults in superficial layers from the ground surface and is complementary to 3D seismic reflection surveys.

  2. Bacillus subtilis as a platform for molecular characterisation of regulatory mechanisms of Enterococcus faecalis resistance against cell wall antibiotics.

    Science.gov (United States)

    Fang, Chong; Stiegeler, Emanuel; Cook, Gregory M; Mascher, Thorsten; Gebhard, Susanne

    2014-01-01

    To combat antibiotic resistance of Enterococcus faecalis, a better understanding of the molecular mechanisms, particularly of antibiotic detection, signal transduction and gene regulation is needed. Because molecular studies in this bacterium can be challenging, we aimed at exploiting the genetically highly tractable Gram-positive model organism Bacillus subtilis as a heterologous host. Two fundamentally different regulators of E. faecalis resistance against cell wall antibiotics, the bacitracin sensor BcrR and the vancomycin-sensing two-component system VanSB-VanRB, were produced in B. subtilis and their functions were monitored using target promoters fused to reporter genes (lacZ and luxABCDE). The bacitracin resistance system BcrR-BcrAB of E. faecalis was fully functional in B. subtilis, both regarding regulation of bcrAB expression and resistance mediated by the transporter BcrAB. Removal of intrinsic bacitracin resistance of B. subtilis increased the sensitivity of the system. The lacZ and luxABCDE reporters were found to both offer sensitive detection of promoter induction on solid media, which is useful for screening of large mutant libraries. The VanSB-VanRB system displayed a gradual dose-response behaviour to vancomycin, but only when produced at low levels in the cell. Taken together, our data show that B. subtilis is a well-suited host for the molecular characterization of regulatory systems controlling resistance against cell wall active compounds in E. faecalis. Importantly, B. subtilis facilitates the careful adjustment of expression levels and genetic background required for full functionality of the introduced regulators.

  3. Bacillus subtilis as a platform for molecular characterisation of regulatory mechanisms of Enterococcus faecalis resistance against cell wall antibiotics.

    Directory of Open Access Journals (Sweden)

    Chong Fang

    Full Text Available To combat antibiotic resistance of Enterococcus faecalis, a better understanding of the molecular mechanisms, particularly of antibiotic detection, signal transduction and gene regulation is needed. Because molecular studies in this bacterium can be challenging, we aimed at exploiting the genetically highly tractable Gram-positive model organism Bacillus subtilis as a heterologous host. Two fundamentally different regulators of E. faecalis resistance against cell wall antibiotics, the bacitracin sensor BcrR and the vancomycin-sensing two-component system VanSB-VanRB, were produced in B. subtilis and their functions were monitored using target promoters fused to reporter genes (lacZ and luxABCDE. The bacitracin resistance system BcrR-BcrAB of E. faecalis was fully functional in B. subtilis, both regarding regulation of bcrAB expression and resistance mediated by the transporter BcrAB. Removal of intrinsic bacitracin resistance of B. subtilis increased the sensitivity of the system. The lacZ and luxABCDE reporters were found to both offer sensitive detection of promoter induction on solid media, which is useful for screening of large mutant libraries. The VanSB-VanRB system displayed a gradual dose-response behaviour to vancomycin, but only when produced at low levels in the cell. Taken together, our data show that B. subtilis is a well-suited host for the molecular characterization of regulatory systems controlling resistance against cell wall active compounds in E. faecalis. Importantly, B. subtilis facilitates the careful adjustment of expression levels and genetic background required for full functionality of the introduced regulators.

  4. Microfabricated suspended island platform for the measurement of in-plane thermal conductivity of thin films and nanostructured materials with consideration of contact resistance.

    Science.gov (United States)

    Alaie, Seyedhamidreza; Goettler, Drew F; Abbas, Khawar; Su, Mehmet F; Reinke, Charles M; El-Kady, Ihab; Leseman, Zayd C

    2013-10-01

    A technique based on suspended islands is described to measure the in-plane thermal conductivity of thin films and nano-structured materials, and is also employed for measurements of several samples with a single measurement platform. Using systematic steps for measurements, the characterization of the thermal resistances of a sample and its contacts are studied. The calibration of the contacts in this method is independent of the geometry, size, materials, and uniformity of contacts. To verify the technique, two different Si samples with different thicknesses and two samples of the same SiN(x) wafer are characterized on a single device. One of the Si samples is also characterized by another technique, which verifies the current results. Characterization of the two SiN(x) samples taken from the same wafer showed less than 1% difference in the measured thermal conductivities, indicating the precision of the method. Additionally, one of the SiN(x) samples is characterized and then demounted, remounted, and characterized for a second time. The comparison showed the change in the thermal resistance of the contact in multiple measurements could be as small as 0.2 K/μW, if a similar sample is used.

  5. Platform Constellations

    DEFF Research Database (Denmark)

    Staykova, Kalina Stefanova; Damsgaard, Jan

    2016-01-01

    This research paper presents an initial attempt to introduce and explain the emergence of new phenomenon, which we refer to as platform constellations. Functioning as highly modular systems, the platform constellations are collections of highly connected platforms which co-exist in parallel...... and as such allow us to study platforms not only as separate entities, but also to investigate the relationship between several platforms offered and governed by one and the same platform provider. By investigating two case studies of indigenous platform constellations formed around the hugely popular instant...... messaging apps KakaoTalk and LINE, we are able to gain valuable insights about the nature of these new constructions and to capture and synthesize their main characteristics in a framework. Our results show that platform constellations possess unique innovative capabilities, which can improve users...

  6. PRGPred: A platform for prediction of domains of resistance gene analogue (RGA in Arecaceae developed using machine learning algorithms

    Directory of Open Access Journals (Sweden)

    MATHODIYIL S. MANJULA

    2015-12-01

    Full Text Available Plant disease resistance genes (R-genes are responsible for initiation of defense mechanism against various phytopathogens. The majority of plant R-genes are members of very large multi-gene families, which encode structurally related proteins containing nucleotide binding site domains (NBS and C-terminal leucine rich repeats (LRR. Other classes possess' an extracellular LRR domain, a transmembrane domain and sometimes, an intracellular serine/threonine kinase domain. R-proteins work in pathogen perception and/or the activation of conserved defense signaling networks. In the present study, sequences representing resistance gene analogues (RGAs of coconut, arecanut, oil palm and date palm were collected from NCBI, sorted based on domains and assembled into a database. The sequences were analyzed in PRINTS database to find out the conserved domains and their motifs present in the RGAs. Based on these domains, we have also developed a tool to predict the domains of palm R-genes using various machine learning algorithms. The model files were selected based on the performance of the best classifier in training and testing. All these information is stored and made available in the online ‘PRGpred' database and prediction tool.

  7. Next-generation sequencing-based user-friendly platforms for drug-resistant tuberculosis diagnosis: A promise for the near future.

    Science.gov (United States)

    Dolinger, David L; Colman, Rebecca E; Engelthaler, David M; Rodwell, Timothy C

    2016-12-01

    Since 2002, there has been a gradual worldwide 1.3% annual decrease in the incidence of tuberculosis (TB). This is an encouraging statistic; however, it will not achieve the World Health Organization's goal of eliminating TB by 2050, and it is being compounded by the persistent global incidence of drug-resistant tuberculosis (DR-TB) acquired by transmission and by treatment pressure. One key to effectively control tuberculosis and the spread of multiresistant strains is accurate information pertaining to drug resistance and susceptibility. Next-generation sequencing (NGS) has the potential to effectively change global health and the management of TB. Industry has focused primarily on using NGS for oncology diagnostics and human genomics, but the area in which NGS can rapidly impact health care is in the area of infectious disease diagnostics in low- and middle-income countries. To date, there has been a failure as a community to capitalize on the potential of NGS, especially at the reference laboratory level where it can provide actionable information pertaining to treatment options for patients. The rapid evolution of knowledge about the genetic foundations of tuberculosis drug resistance makes sequencing a versatile technology platform for providing rapid, accurate, and actionable results for treating this disease. No "plug-and-play" and "end-to-end" NGS solutions exist that provide clinically relevant sequence data from the Mycobacterium tuberculosis complex genome from primary clinical samples (e.g., sputum) in high-burden country reference laboratories, which is where they are most needed. However, such a system-based solution is underdeveloped by Foundation for Innovative Diagnostics (FIND), in collaboration with partners from academia, nongovernmental organizations, and industry. The solution is modular and is designed and developed to perform targeted amplicon sequencing directly from a patient's primary sputum sample. This solution will initially allow

  8. Next-generation sequencing-based user-friendly platforms for drug-resistant tuberculosis diagnosis: A promise for the near future

    Directory of Open Access Journals (Sweden)

    David L Dolinger

    2016-01-01

    Full Text Available Since 2002, there has been a gradual worldwide 1.3% annual decrease in the incidence of tuberculosis (TB. This is an encouraging statistic; however, it will not achieve the World Health Organization's goal of eliminating TB by 2050, and it is being compounded by the persistent global incidence of drug-resistant tuberculosis (DR-TB acquired by transmission and by treatment pressure. One key to effectively control tuberculosis and the spread of multiresistant strains is accurate information pertaining to drug resistance and susceptibility. Next-generation sequencing (NGS has the potential to effectively change global health and the management of TB. Industry has focused primarily on using NGS for oncology diagnostics and human genomics, but the area in which NGS can rapidly impact health care is in the area of infectious disease diagnostics in low- and middle-income countries. To date, there has been a failure as a community to capitalize on the potential of NGS, especially at the reference laboratory level where it can provide actionable information pertaining to treatment options for patients. The rapid evolution of knowledge about the genetic foundations of tuberculosis drug resistance makes sequencing a versatile technology platform for providing rapid, accurate, and actionable results for treating this disease. No “plug-and-play” and “end-to-end” NGS solutions exist that provide clinically relevant sequence data from the Mycobacterium tuberculosis complex genome from primary clinical samples (e.g., sputum in high-burden country reference laboratories, which is where they are most needed. However, such a system-based solution is underdeveloped by Foundation for Innovative Diagnostics (FIND, in collaboration with partners from academia, nongovernmental organizations, and industry. The solution is modular and is designed and developed to perform targeted amplicon sequencing directly from a patient's primary sputum sample. This solution

  9. Payment Platform

    DEFF Research Database (Denmark)

    Hjelholt, Morten; Damsgaard, Jan

    2012-01-01

    Payment transactions through the use of physical coins, bank notes or credit cards have for centuries been the standard formats of exchanging money. Recently online and mobile digital payment platforms has entered the stage as contenders to this position and possibly could penetrate societies...... thoroughly and substitute current payment standards in the decades to come. This paper portrays how digital payment platforms evolve in socio-technical niches and how various technological platforms aim for institutional attention in their attempt to challenge earlier platforms and standards. The paper...... applies a co-evolutionary multilevel perspective to model the interplay and processes between technology and society wherein digital payment platforms potentially will substitute other payment platforms just like the credit card negated the check. On this basis this paper formulate a multilevel conceptual...

  10. Evaluation of the Xpert Methicillin-Resistant Staphylococcus aureus (MRSA) Assay Using the GeneXpert Real-Time PCR Platform for Rapid Detection of MRSA from Screening Specimens ▿

    OpenAIRE

    Rossney, Angela S.; Herra, Celine M, Dr; Brennan, Gráinne I.; Morgan, Pamela M.; O'Connell, Brian

    2008-01-01

    The need for rapid methods to accurately detect methicillin-resistant Staphylococcus aureus (MRSA) is widely acknowledged, and a number of molecular assays are commercially available. This study evaluated the Xpert MRSA assay, which is run on the GeneXpert real-time PCR platform (Cepheid) for use in a clinical laboratory. The following parameters were investigated: (i) the limits of detection (LoDs) for four MRSA strains; (ii) the ability to detect isolates of MRSA from a collection represent...

  11. An Efficient Microarray-Based Genotyping Platform for the Identification of Drug-Resistance Mutations in Majority and Minority Subpopulations of HIV-1 Quasispecies.

    Science.gov (United States)

    Martín, Verónica; Perales, Celia; Fernández-Algar, María; Dos Santos, Helena G; Garrido, Patricia; Pernas, María; Parro, Víctor; Moreno, Miguel; García-Pérez, Javier; Alcamí, José; Torán, José Luis; Abia, David; Domingo, Esteban; Briones, Carlos

    2016-01-01

    The response of human immunodeficiency virus type 1 (HIV-1) quasispecies to antiretroviral therapy is influenced by the ensemble of mutants that composes the evolving population. Low-abundance subpopulations within HIV-1 quasispecies may determine the viral response to the administered drug combinations. However, routine sequencing assays available to clinical laboratories do not recognize HIV-1 minority variants representing less than 25% of the population. Although several alternative and more sensitive genotyping techniques have been developed, including next-generation sequencing (NGS) methods, they are usually very time consuming, expensive and require highly trained personnel, thus becoming unrealistic approaches in daily clinical practice. Here we describe the development and testing of a HIV-1 genotyping DNA microarray that detects and quantifies, in majority and minority viral subpopulations, relevant mutations and amino acid insertions in 42 codons of the pol gene associated with drug- and multidrug-resistance to protease (PR) and reverse transcriptase (RT) inhibitors. A customized bioinformatics protocol has been implemented to analyze the microarray hybridization data by including a new normalization procedure and a stepwise filtering algorithm, which resulted in the highly accurate (96.33%) detection of positive/negative signals. This microarray has been tested with 57 subtype B HIV-1 clinical samples extracted from multi-treated patients, showing an overall identification of 95.53% and 89.24% of the queried PR and RT codons, respectively, and enough sensitivity to detect minority subpopulations representing as low as 5-10% of the total quasispecies. The developed genotyping platform represents an efficient diagnostic and prognostic tool useful to personalize antiviral treatments in clinical practice.

  12. An Efficient Microarray-Based Genotyping Platform for the Identification of Drug-Resistance Mutations in Majority and Minority Subpopulations of HIV-1 Quasispecies

    Science.gov (United States)

    Martín, Verónica; Perales, Celia; Fernández-Algar, María; Dos Santos, Helena G.; Garrido, Patricia; Pernas, María; Parro, Víctor; Moreno, Miguel; García-Pérez, Javier; Alcamí, José; Torán, José Luis; Abia, David; Domingo, Esteban

    2016-01-01

    The response of human immunodeficiency virus type 1 (HIV-1) quasispecies to antiretroviral therapy is influenced by the ensemble of mutants that composes the evolving population. Low-abundance subpopulations within HIV-1 quasispecies may determine the viral response to the administered drug combinations. However, routine sequencing assays available to clinical laboratories do not recognize HIV-1 minority variants representing less than 25% of the population. Although several alternative and more sensitive genotyping techniques have been developed, including next-generation sequencing (NGS) methods, they are usually very time consuming, expensive and require highly trained personnel, thus becoming unrealistic approaches in daily clinical practice. Here we describe the development and testing of a HIV-1 genotyping DNA microarray that detects and quantifies, in majority and minority viral subpopulations, relevant mutations and amino acid insertions in 42 codons of the pol gene associated with drug- and multidrug-resistance to protease (PR) and reverse transcriptase (RT) inhibitors. A customized bioinformatics protocol has been implemented to analyze the microarray hybridization data by including a new normalization procedure and a stepwise filtering algorithm, which resulted in the highly accurate (96.33%) detection of positive/negative signals. This microarray has been tested with 57 subtype B HIV-1 clinical samples extracted from multi-treated patients, showing an overall identification of 95.53% and 89.24% of the queried PR and RT codons, respectively, and enough sensitivity to detect minority subpopulations representing as low as 5–10% of the total quasispecies. The developed genotyping platform represents an efficient diagnostic and prognostic tool useful to personalize antiviral treatments in clinical practice. PMID:27959928

  13. [Lens platform].

    Science.gov (United States)

    Łukaszewska-Smyk, Agnieszka; Kałuzny, Józef

    2010-01-01

    The lens platform defines lens structure and lens material. Evolution of lens comprises change in their shape, angulation of haptens and transition of three-piece lens into one-piece lens. The lens fall into two categories: rigid (PMMA) and soft (siliconic, acrylic, colameric). The main lens maaterials are polymers (hydrophilic and hydrophobic). The lens platform has an effect on biocompatibility, bioadhesion, stability of lens in capsule, degree of PCO evolution and sensitiveness to laser damages.

  14. Platform contents

    OpenAIRE

    Renault, Régis

    2014-01-01

    A monopoly platform hosts advertisers who compete on a market for horizontally differentiated products. These products may be either mass market products that appeal broadly to the entire consumer population or niche products that are tailored to the tastes of some particular group. Consumers search sequentially through ads incurring a surfing cost of moving to the next ad. They may click on an ad at some cost, which provides all relevant information and the opportunity to buy. The platform c...

  15. Platforms for antibiotic discovery.

    Science.gov (United States)

    Lewis, Kim

    2013-05-01

    The spread of resistant bacteria, leading to untreatable infections, is a major public health threat but the pace of antibiotic discovery to combat these pathogens has slowed down. Most antibiotics were originally isolated by screening soil-derived actinomycetes during the golden era of antibiotic discovery in the 1940s to 1960s. However, diminishing returns from this discovery platform led to its collapse, and efforts to create a new platform based on target-focused screening of large libraries of synthetic compounds failed, in part owing to the lack of penetration of such compounds through the bacterial envelope. This article considers strategies to re-establish viable platforms for antibiotic discovery. These include investigating untapped natural product sources such as uncultured bacteria, establishing rules of compound penetration to enable the development of synthetic antibiotics, developing species-specific antibiotics and identifying prodrugs that have the potential to eradicate dormant persisters, which are often responsible for hard-to-treat infections.

  16. Vaulted trans-bis(salicylaldiminato)platinum(II) crystals: heat-resistant, chromatically sensitive platforms for solid-state phosphorescence at ambient temperature.

    Science.gov (United States)

    Komiya, Naruyoshi; Okada, Minoru; Fukumoto, Kanako; Kaneta, Kenji; Yoshida, Atsushi; Naota, Takeshi

    2013-04-08

    The synthesis, structure, and solid-state emission of vaulted trans-bis(salicylaldiminato)platinum(II) complexes are described. A series of polymethylene (1: n=8; 2: n=9; 3: n=10; 4: n=11; 5: n=12; 6: n=13) and polyoxyethylene (7: m=2; 8: m=3; 9: m=4) vaulted complexes (R=H (a), 3-MeO (b), 4-MeO (c), 5-MeO (d), 6-MeO (e), 4-CF3O (f), 5-CF3O (g)) was prepared by treating [PtCl2(CH3CN)2] with the corresponding N,N'-bis(salicylidene)-1,ω-alkanediamines. The trans coordination, vaulted structures, and the crystal packing of 1-9 have been unequivocally established from X-ray diffraction studies. Unpredictable, structure-dependent phosphorescent emission has been observed for crystals of the complexes under UV excitation at ambient temperature, whereas these complexes are entirely nonemissive in the solution state under the same conditions. The long-linked complex crystals 4-6, 8, and 9 exhibit intense emission (Φ77K =0.22-0.88) at 77 K, whereas short-linked complexes 1-3 and 7 are non- or slightly emissive at the same temperature (Φ77K solid-state emission over the range of 98 nm can be performed simply by introducing MeO groups at different positions on the aromatic rings. Orange, yellow-green, red, and yellow emissions are observed in the glass and crystalline state upon 3-, 4-, 5-, and 6-MeO substitution, respectively, whereas those with CF3 O substituents have orange emission, irrespective of the substitution position. DFT calculations (B3LYP/6-31G*, LanL2DZ) showed that such chromatic variation is ascribed to the position-specific influence of the substituents on the highest-occupied molecular orbital (HOMO) and lowest-unoccupied molecular orbital (LUMO) levels of the trans-bis(salicylaldiminato)platinum(II) platform. The solid-state emission and its heat resistance have been discussed on the basis of X-ray diffraction studies. The planarity of the trans-coordination sites is strongly correlated to the solid-state emission intensities of crystals 1-9 at lower

  17. ITS Platform

    DEFF Research Database (Denmark)

    Tøfting, Svend; Lahrmann, Harry; Agerholm, Niels

    2014-01-01

    Aalborg University and two local companies have over the past four years developed and tested an ITS Platform, which can be used for communication with cars and for providing a number of services to the drivers. The purpose has been to perform a technological test of the possible use of a hidden ...... not have to be very intelligent. This is gradually taken over by applications on smart phones. The ITS Platform with 425 test drivers is now completely developed and can be used for technological testing of e.g. payment systems.......Aalborg University and two local companies have over the past four years developed and tested an ITS Platform, which can be used for communication with cars and for providing a number of services to the drivers. The purpose has been to perform a technological test of the possible use of a hidden...

  18. ITS Platform

    DEFF Research Database (Denmark)

    Tøfting, Svend; Lahrmann, Harry; Agerholm, Niels

    2014-01-01

    Aalborg University and two local companies have over the past four years developed and tested an ITS Platform, which can be used for communication with cars and for providing a number of services to the drivers. The purpose has been to perform a technological test of the possible use of a hidden ...... not have to be very intelligent. This is gradually taken over by applications on smart phones. The ITS Platform with 425 test drivers is now completely developed and can be used for technological testing of e.g. payment systems....

  19. Platform computing

    CERN Multimedia

    2002-01-01

    "Platform Computing releases first grid-enabled workload management solution for IBM eServer Intel and UNIX high performance computing clusters. This Out-of-the-box solution maximizes the performance and capability of applications on IBM HPC clusters" (1/2 page) .

  20. Platform Constellations

    DEFF Research Database (Denmark)

    Staykova, Kalina Stefanova; Damsgaard, Jan

    2016-01-01

    messaging apps KakaoTalk and LINE, we are able to gain valuable insights about the nature of these new constructions and to capture and synthesize their main characteristics in a framework. Our results show that platform constellations possess unique innovative capabilities, which can improve users......’ acquisition and users’ engagement rates as well as unlock new sources of value creation and diversify revenue streams....

  1. Experimental Platform Design on Flowing Resistance of Air Vents for Bullet Train%高速动车换气口流动阻力实验台设计

    Institute of Scientific and Technical Information of China (English)

    何忠韬; 方海容

    2013-01-01

    探讨了高速动车换气口流动阻力实验台相关问题,根据流体力学相关原理,提出用低速风洞模拟列车外界风速场,换气口试件置于风洞试验段中,将列车外界风速、流经换气口的风量模拟量都设计成可调控的实验参数,搭建了用于换气口流动阻力及其影响因素的实验平台。实验实例表明,本文方法建立的高速动车换气口流动阻力实验台方案是可行的,测量结果是可信的。%Problems about an experimental platform are discussed,recurring to which,the flowing resistance of air vents on the bullet train can be researched.According to the principle of fluid mechanics,it is put forward that the train wind field outside can be simulated by the low speed wind tunnel,the ventilation test piece is placed in the test section of wind tunnel,the wind speed outside and the flowing rate through the air vents are tunable,then a experimental platform for flowing resistance of air vents is built.The experimental results show that the scheme of the experimental platform is feasible,and the measurement results are credible.

  2. DESIGN OF OFFSHORE CONCRETE GRAVITY PLATFORMS

    African Journals Online (AJOL)

    loads from earth-quake for (earth-quake prone zones) are deployed to archive the design and ... Keywords: concrete gravity platform, offshore, foundation design, manufacturing, construction .... resistance to wind offered by such ice accumu-.

  3. A Public Platform for the Verification of the Phenotypic Effect of Candidate Genes for Resistance to Aflatoxin Accumulation and Aspergillus flavus Infection in Maize

    Directory of Open Access Journals (Sweden)

    Xueyan Shan

    2011-06-01

    Full Text Available A public candidate gene testing pipeline for resistance to aflatoxin accumulation or Aspergillus flavus infection in maize is presented here. The pipeline consists of steps for identifying, testing, and verifying the association of selected maize gene sequences with resistance under field conditions. Resources include a database of genetic and protein sequences associated with the reduction in aflatoxin contamination from previous studies; eight diverse inbred maize lines for polymorphism identification within any maize gene sequence; four Quantitative Trait Loci (QTL mapping populations and one association mapping panel, all phenotyped for aflatoxin accumulation resistance and associated phenotypes; and capacity for Insertion/Deletion (InDel and SNP genotyping in the population(s for mapping. To date, ten genes have been identified as possible candidate genes and put through the candidate gene testing pipeline, and results are presented here to demonstrate the utility of the pipeline.

  4. The TB Portals: An open-access, web-based platform for global drug-resistant tuberculosis data sharing and analysis.

    Science.gov (United States)

    Rosenthal, Alex; Gabrielian, Andrei; Engle, Eric; Hurt, Darrell E; Alexandru, Sofia; Crudu, Valeriu; Sergueev, Eugene; Kirichenko, Valery; Lapitskii, Vladzimir; Snezhko, Eduard; Kovalev, Vassili; Astrovko, Andrei; Skrahina, Alena; Taaffe, Jessica; Harris, Michael; Long, Alyssa; Wollenberg, Kurt; Akhundova, Irada; Ismayilova, Sharafat; Skrahin, Aliaksandr; Mammadbayov, Elcan; Gadirova, Hagigat; Abuzarov, Rafik; Seyfaddinova, Mehriban; Avaliani, Zaza; Strambu, Irina; Zaharia, Dragos; Muntean, Alexandru; Ghita, Eugenia; Bogdan, Miron; Mindru, Roxana; Spinu, Victor; Sora, Alexandra; Ene, Catalina; Vashakidze, Sergo; Shubladze, Natalia; Nanava, Ucha; Tuzikov, Alexander; Tartakovsky, Michael

    2017-09-13

    The TB Portals Program is an international consortium of physicians, radiologists, and microbiologists from countries with a heavy burden of drug-resistant tuberculosis working with data scientists and IT professionals. Together, we have built the TB Portals, a repository of socioeconomic/geographic, clinical, laboratory, radiological, and genomic data from patient cases of drug-resistant tuberculosis and backed by shareable, physical samples. Currently, there are 1,299 total cases from five country sites (Azerbaijan, Belarus, Moldova, Georgia, and Romania), of which 976 (75.1%) are multi- or extensively drug resistant, and 38.2%, 51.9%, and 36.3% of cases contain X-ray, CT scan, and genomic data, respectively. The top Mycobacterium tuberculosis lineages represented among collected samples are Beijing, T1, and H3, and SNPs that confer resistance to isoniazid, rifampicin, ofloxacin, and moxifloxacin occur the most frequently. These data and samples have promoted drug discovery efforts and research into genomics and quantitative image analysis to improve diagnostics, while also serving as a valuable resource for researchers and clinical providers. The TB Portals database and associated projects are continually growing, and we invite new partners and collaborations in our initiative. The TB Portals data and their associated analytical and statistical tools are freely available at: https://tbportals.niaid.nih.gov.

  5. Evaluation of the Quantamatrix Multiplexed Assay Platform system for simultaneous detection of Mycobacterium tuberculosis and the rifampicin resistance gene using cultured mycobacteria

    Directory of Open Access Journals (Sweden)

    Hye-young Wang

    2017-08-01

    Conclusions: The entire QMAP system assay takes about 3 h to complete, while results from the culture-based conventional method can take up to 48–72 h. Although improvements to the QMAP system are needed for direct respiratory specimens, it may be useful for rapid screening, not only to identify and accurately discriminate MTBC from NTM, but also to identify RIF-resistant MTB strains in positive culture samples.

  6. The Dynamics of Digital Platform Innovation

    DEFF Research Database (Denmark)

    Eaton, Ben

    2016-01-01

    Curated platforms provide an architectural basis for third parties to develop platform complements and for platform owners to control their implementation as a form of open innovation. The refusal to implement complements as innovations can cause tension between platform owners and developers....... The dynamic concerning this control of innovation is not well understood in platform literature. This research attempts to address that gap by using qualitative methods to build narrative networks which analyze 45 examples of contested platform innovation. This approach, informed by empirical data sourced...... from 4664 blogs, identifies patterned sequences of actions describing tussles across the examples. Mechanisms are then identified, which explain how control is asserted and resisted. The principle contribution of this research is to describe and explain the dynamics of contested innovation on curated...

  7. Product Platform Performance

    DEFF Research Database (Denmark)

    Munk, Lone

    engaging in platform-based product development. Similarly platform assessment criteria lack empirical verification regarding relevance and sufficiency. The thesis focuses on • the process of identifying and estimating internal effects, • verification of performance of product platforms, (i...... to support this understanding. Finally a categorisation of different approaches to platform-based product development is introduced, based on the companies from the industrial study.......The aim of this research is to improve understanding of platform-based product development by studying platform performance in relation to internal effects in companies. Platform-based product development makes it possible to deliver product variety and at the same time reduce the needed resources...

  8. Product Platform Modeling

    DEFF Research Database (Denmark)

    Pedersen, Rasmus

    on the notion that reuse and encapsulation of platform elements are fundamental characteristics of a product platform. Reuse covers the desire to reuse and share certain assets across a family of products and/or across generations of products. Product design solutions and principles are often regarded...... as important assets in a product platform, yet activities, working patterns, processes and knowledge can also be reused in a platform approach. Encapsulation is seen as a process in which the different elements of a platform are grouped into well defined and self-contained units which are decoupled from each......This PhD thesis has the title Product Platform Modelling. The thesis is about product platforms and visual product platform modelling. Product platforms have gained an increasing attention in industry and academia in the past decade. The reasons are many, yet the increasing globalisation...

  9. OVERVIEW AND CLASSIFICATION OF PERMANENT OFFSHORE PLATFORMS FOR WORKING IN ICE CONDITIONS

    OpenAIRE

    Mr. Nikolay A. Taranukha; Mr Andrey S. Mironov

    2016-01-01

    This article is dedicated to permanent offshore platforms for working in ice conditions. The authors focus on creating constructions for working in ice conditions. The article presents drawings of ice-resistant permanent offshore platforms according to their attachment to the seabed. The article also describes the scheme of the general arrangement of the ice-resistant tetrahedral permanent offshore platforms.

  10. ITS Platform North Denmark

    DEFF Research Database (Denmark)

    Lahrmann, Harry; Agerholm, Niels; Juhl, Jens

    2012-01-01

    This paper presents the project entitled “ITS Platform North Denmark” which is used as a test platform for Intelligent Transportation System (ITS) solutions. The platform consists of a newly developed GNSS/GPRS On Board Unit (OBU) to be installed in 500 cars, a backend server and a specially...... designed digital road map for ITS applications. The platform is freely accessible, which means that third party applications could be run on the platform. It is estimated that using this platform enables the ITS applications to be developed for 20% of the normal cost, hence third party are invited to test...... their applications in this platform. This paper presents the platform’s potentials and explains a series of test applications which are under development on it. Moreover, a number of new projects planned for the platform are demonstrated....

  11. Mobile platform security

    CERN Document Server

    Asokan, N; Dmitrienko, Alexandra

    2013-01-01

    Recently, mobile security has garnered considerable interest in both the research community and industry due to the popularity of smartphones. The current smartphone platforms are open systems that allow application development, also for malicious parties. To protect the mobile device, its user, and other mobile ecosystem stakeholders such as network operators, application execution is controlled by a platform security architecture. This book explores how such mobile platform security architectures work. We present a generic model for mobile platform security architectures: the model illustrat

  12. Continuous Platform Development

    DEFF Research Database (Denmark)

    Nielsen, Ole Fiil

    low risks and investments but also with relatively fuzzy results. When looking for new platform projects, it is important to make sure that the company and market is ready for the introduction of platforms, and to make sure that people from marketing and sales, product development, and downstream......, but continuous product family evolution challenges this strategy. The concept of continuous platform development is based on the fact that platform development should not be a one-time experience but rather an ongoing process of developing new platforms and updating existing ones, so that product family...

  13. 一种应变式超低频微振动测试台%An ultra-low frequency micro-vibration testing platform based on strain-resistance effect

    Institute of Scientific and Technical Information of China (English)

    陈江攀; 程伟; 夏明一

    2014-01-01

    In order to measure micro-vibration of a SADA (solar array drive assembly ) in low and ultra-low frequency zone caused by electromechanical coupling,a six-component testing platform based on strain-resistance effect was developed.Its response characteristic in low frequency zone was outstanding and its installation interface was flexible. The working principle and dynamic calibration method of this platform were introduced in detail.In order to assess the performance of this testing platform,linearity examination,natural frequencies measurement and dynamic testing error examination for it were done.The results showed that linearity errors of eight force sensors are within 3.4% under the action of external force within 1 00N;there are no natural frequencies within 1 00Hz,so that the micro-vibration signals can not be modulated through structural coupling in frequency domain of (0 -1 00Hz );dynamic testing errors of six components are within ±9.6% in frequency domain of (0 -1 00Hz),testing resolutions of three forces and three moments can reach 0.0lN and 0.001 N.m,respectively.%为了测试卫星太阳翼驱动机构低频、超低频区由机电耦合产生的微振动,发明了一种应变式超低频微振动六分量测试台,该测试台低频响应特性好,安装接口灵活。介绍该测试台的工作原理和动态标定方法,并对该测试台进行了线性度检验、固有频率测试以及动态测试误差检验。通过线性度检验可得:在100 N范围内的外力作用下,组成该测试台的八个双孔梁应变式力传感器的线性度相对误差在±3.4%以内;通过固有频率测试可得:该测试台在100 Hz内没有固有频率,不会通过结构耦合对被测微振动信号进行调制;通过动态测试误差检验可得:在频域上0!100 Hz范围内,该测试台对六个分量动态测试的相对误差在±9.6%以内,同时还可以得出该测试台对三个力分量和三个力矩分量

  14. Paper based electronics platform

    KAUST Repository

    Nassar, Joanna Mohammad

    2017-07-20

    A flexible and non-functionalized low cost paper-based electronic system platform fabricated from common paper, such as paper based sensors, and methods of producing paper based sensors, and methods of sensing using the paper based sensors are provided. A method of producing a paper based sensor can include the steps of: a) providing a conventional paper product to serve as a substrate for the sensor or as an active material for the sensor or both, the paper product not further treated or functionalized; and b) applying a sensing element to the paper substrate, the sensing element selected from the group consisting of a conductive material, the conductive material providing contacts and interconnects, sensitive material film that exhibits sensitivity to pH levels, a compressible and/or porous material disposed between a pair of opposed conductive elements, or a combination of two of more said sensing elements. The method of sensing can further include measuring, using the sensing element, a change in resistance, a change in voltage, a change in current, a change in capacitance, or a combination of any two or more thereof.

  15. Cross-Platform Technologies

    Directory of Open Access Journals (Sweden)

    Maria Cristina ENACHE

    2017-04-01

    Full Text Available Cross-platform - a concept becoming increasingly used in recent years especially in the development of mobile apps, but this consistently over time and in the development of conventional desktop applications. The notion of cross-platform software (multi-platform or platform-independent refers to a software application that can run on more than one operating system or computing architecture. Thus, a cross-platform application can operate independent of software or hardware platform on which it is execute. As a generic definition presents a wide range of meanings for purposes of this paper we individualize this definition as follows: we will reduce the horizon of meaning and we use functionally following definition: a cross-platform application is a software application that can run on more than one operating system (desktop or mobile identical or in a similar way.

  16. Synthetic biology platform technologies for antimicrobial applications.

    Science.gov (United States)

    Braff, Dana; Shis, David; Collins, James J

    2016-10-01

    The growing prevalence of antibiotic resistance calls for new approaches in the development of antimicrobial therapeutics. Likewise, improved diagnostic measures are essential in guiding the application of targeted therapies and preventing the evolution of therapeutic resistance. Discovery platforms are also needed to form new treatment strategies and identify novel antimicrobial agents. By applying engineering principles to molecular biology, synthetic biologists have developed platforms that improve upon, supplement, and will perhaps supplant traditional broad-spectrum antibiotics. Efforts in engineering bacteriophages and synthetic probiotics demonstrate targeted antimicrobial approaches that can be fine-tuned using synthetic biology-derived principles. Further, the development of paper-based, cell-free expression systems holds promise in promoting the clinical translation of molecular biology tools for diagnostic purposes. In this review, we highlight emerging synthetic biology platform technologies that are geared toward the generation of new antimicrobial therapies, diagnostics, and discovery channels. Copyright © 2016 Elsevier B.V. All rights reserved.

  17. Platform switching and bone platform switching.

    Science.gov (United States)

    Carinci, Francesco; Brunelli, Giorgio; Danza, Matteo

    2009-01-01

    Bone platform switching involves an inward bone ring in the coronal part of the implant that is in continuity with the alveolar bone crest. Bone platform switching is obtained by using a dental fixture with a reverse conical neck. A retrospective study was performed to evaluate the effectiveness of conventional vs reverse conical neck implants. In the period between May 2004 and November 2007, 86 patients (55 females and 31 males; median age, 53 years) were operated and 234 implants were inserted: 40 and 194 were conventional vs reverse conical neck implants, respectively. Kaplan-Meier algorithm and Cox regression were used to detect those variables associated with the clinical outcome. No differences in survival and success rates were detected between conventional vs reverse conical neck implants alone or in combination with any of the studied variables. Although bone platform switching leads to several advantages, no statistical difference in alveolar crest resorption is detected in comparison with reverse conical neck implants. We suppose that the proximity of the implant abutment junction to the alveolar crestal bone gives no protection against the microflora contained in the micrograph. Additional studies on larger series and a combination of platform switching and bone platform switching could lead to improved clinical outcomes.

  18. Platform development supportedby gaming

    DEFF Research Database (Denmark)

    Mikkola, Juliana Hsuan; Hansen, Poul H. Kyvsgård

    2007-01-01

    The challenge of implementing industrial platforms in practice can be described as a configuration problem caused by high number of variables, which often have contradictory influences on the total performance of the firm. Consequently, the specific platform decisions become extremely complex......, possibly increasing the strategic risks for the firm. This paper reports preliminary findings on platform management process at LEGO, a Danish toy company.  Specifically, we report the process of applying games combined with simulations and workshops in the platform development. We also propose a framework......, based on the portfolio management thinking, to measure the degree of modularity embedded in a given platform and to what extent it is aligned with other platforms....

  19. DFH-3 Satellite Platform

    Institute of Scientific and Technical Information of China (English)

    RenShufang

    2005-01-01

    The DFH-3 satellite platform is designed and developed by China Academy of Space Technology (CAST). It is a medium capability communications satellite platform. The platform adopts threeaxis attitude stabilization control system, having solar array output power of 1.7kW by the end of its design lifetime of 8 years. Its mass is 2100kg with payload capacity of 220kg.

  20. Product Platform Replacements

    DEFF Research Database (Denmark)

    Sköld, Martin; Karlsson, Christer

    2012-01-01

    Purpose – It is argued in this article that too little is known about product platforms and how to deal with them from a manager's point of view. Specifically, little information exists regarding when old established platforms are replaced by new generations in R&D and production environments...... originality and value is achieved by focusing on product platform replacements believed to represent a growing management challenge....

  1. The Creative Platform

    DEFF Research Database (Denmark)

    Byrge, Christian; Hansen, Søren

    This book is about introducing more creativity into general educational courses and cross-disciplinary activities. It is directed toward teachers at all levels in the educational system, but the Creative Platform is a general model, and thus the creative process will fundamentally be the same...... whether you consider thirdgrade teaching, human-resource development, or radical new thinking in product development in a company. The Creative Platform was developed at Aalborg University through a series of research-and-development activities in collaboration with educational institutions and private...... you can use in your work with the Creative Platform. This book is intended as an introduction on how to use the Creative Platform....

  2. Omnidirectional holonomic platforms

    Energy Technology Data Exchange (ETDEWEB)

    Pin, F.G.; Killough, S.M.

    1994-06-01

    This paper presents the concepts for a new family of wheeled platforms which feature full omnidirectionality with simultaneous and independently controlled rotational and translational motion capabilities. The authors first present the orthogonal-wheels concept and the two major wheel assemblies on which these platforms are based. They then describe how a combination of these assemblies with appropriate control can be used to generate an omnidirectional capability for mobile robot platforms. The design and control of two prototype platforms are then presented and their respective characteristics with respect to rotational and translational motion control are discussed.

  3. Advanced offshore oil platforms

    Energy Technology Data Exchange (ETDEWEB)

    Ellers, F.S.

    1982-04-01

    Four innovative offshore platforms that are designed to withstand 100-foot waves in waters 600-feet deep are described. These platforms are: (1) Stratfjord B Concrete Gravity-Base Platform; (2) Magnus Steel-Template-Jacket Platform; (3) Hutton Tension-Leg Platform; and (4) Block 280 Guyed Tower. The Statfjord B platform, designed in Norway, rests on four massive concrete columns with storage tanks at the base. It depends solely on its own mass for stability. The Magnus platform, designed by the British, is the heaviest offshore platform yet fabricated, weighing 41,000 tons. Two of the platform's four legs will incorporate flotation chambers so that the structure can be floated to its site in the North Sea. The Hutton structure, also designed in England, will consist of a buoyant hull tethered to the sea floor by slender steel tubes at its four corners. The first platform of its type, the Hutton structure is also destined for the North Sea. The US designed Block 280 guyed tower is designed for service in the Gulf of Mexico in water 1000 feet deep. It will be pinned to the sea floor by a spokelike array of 20 steel cables, each one more than 3000 feet long. The tower and its guys will weigh 43,000 tons, slightly more than the Magnus steel-template jacket and more than four time as much as the Eiffel Tower. At a cost of approximately $2.6 billion, the Magnus is the most expensive offshore platform to date. The Statfjord B was put into production in 1982. The Magnus is scheduled for oil production in 1983. The Hutton and the Block 280 will both be producing in 1984. (JMT)

  4. EURESCOM Services Platform

    NARCIS (Netherlands)

    Nieuwenhuis, Lambertus Johannes Maria; van Halteren, Aart

    1999-01-01

    This paper presents the results of the EURESCOM Project 715. In February 1999, a large team of researchers from six European public network operators completed a two year period of cooperative experiments on a TINA-based environment, called the EURESCOM Services Platform (ESP). This platform

  5. INTERNAL CORROSION MONITORING IN OFFSHORE PLATFORMS

    Directory of Open Access Journals (Sweden)

    Fernando Benedicto Mainier

    2008-08-01

    Full Text Available Corrosion is one of the main causes of failures in equipment and pipes in off-shore oil production. These failures harm the process, slow the production operational chronogram, and generate high costs of maintenance, beyond generation risks to health and environment. Due to the fact that most of the equipment, tubing and pipes of production platforms are made of steel, in general, carbon steel, the industry of petroleum exploration will always coexist with the corrosive process. The use of a Corrosion Monitoring Plan to diagnostic, to control and to manage the evolution of corrosives process in off-shore oil platforms is the strategy proposed in this work to prevent problems as described above. The Internal Corrosion Monitoring Plan (ICMP, is based on lab analysis of the corrosively of fluids and residues showed periodically in off-shore operational platform; in the corrosion rate determined by the periodic use of test bodies installed inside off-shore oil platforms tubing systems, as mass loss coupons and electric resistance probes; and finally, in periodic operational data collect obtained during the off-shore oil platform systems operation. The ICMP will direct and manage the actions to be taken in case of aggravation of a corrosive process, quickly identifying to the corrosive mechanisms and its localization in the various systems of the platforms. The optimized use of the corrosion inhibitor and other chemical products are one of the main advantages of the ICMP.

  6. The Common HOL Platform

    OpenAIRE

    Adams, Mark

    2015-01-01

    The Common HOL project aims to facilitate porting source code and proofs between members of the HOL family of theorem provers. At the heart of the project is the Common HOL Platform, which defines a standard HOL theory and API that aims to be compatible with all HOL systems. So far, HOL Light and hol90 have been adapted for conformance, and HOL Zero was originally developed to conform. In this paper we provide motivation for a platform, give an overview of the Common HOL Platform's theory and...

  7. Ladder attachment platform

    Science.gov (United States)

    Swygert,; Richard, W [Springfield, SC

    2012-08-28

    A ladder attachment platform is provided that includes a base for attachment to a ladder that has first and second side rails and a plurality of rungs that extend between in a lateral direction. Also included is a user platform for having a user stand thereon that is carried by the base. The user platform may be positioned with respect to the ladder so that it is not located between a first plane that extends through the first side rail and is perpendicular to the lateral direction and a second plane that extends through the second side rail and is perpendicular to the lateral direction.

  8. Platform-based production development

    DEFF Research Database (Denmark)

    Bossen, Jacob; Brunoe, Thomas Ditlev; Nielsen, Kjeld

    2015-01-01

    Platforms as a means for applying modular thinking in product development is relatively well studied, but platforms in the production system has until now not been given much attention. With the emerging concept of platform-based co-development the importance of production platforms is though...... indisputable. This paper presents state-of-the-art literature on platform research related to production platforms and investigates gaps in the literature. The paper concludes on findings by proposing future research directions....

  9. USA Hire Testing Platform

    Data.gov (United States)

    Office of Personnel Management — The USA Hire Testing Platform delivers tests used in hiring for positions in the Federal Government. To safeguard the integrity of the hiring processes and ensure...

  10. MULTIFUNCTIONAL PLATFORMS AND

    African Journals Online (AJOL)

    Solar service centres and multifunctional platforms are innovative concepts for providing energy services in ... same time generate income. obeng ..... communities the driving force behind the ... operator(s) had to contact repairers outside their.

  11. The Common HOL Platform

    Directory of Open Access Journals (Sweden)

    Mark Adams

    2015-07-01

    Full Text Available The Common HOL project aims to facilitate porting source code and proofs between members of the HOL family of theorem provers. At the heart of the project is the Common HOL Platform, which defines a standard HOL theory and API that aims to be compatible with all HOL systems. So far, HOL Light and hol90 have been adapted for conformance, and HOL Zero was originally developed to conform. In this paper we provide motivation for a platform, give an overview of the Common HOL Platform's theory and API components, and show how to adapt legacy systems. We also report on the platform's successful application in the hand-translation of a few thousand lines of source code from HOL Light to HOL Zero.

  12. The Creative Platform

    DEFF Research Database (Denmark)

    Byrge, Christian; Hansen, Søren

    whether you consider thirdgrade teaching, human-resource development, or radical new thinking in product development in a company. The Creative Platform was developed at Aalborg University through a series of research-and-development activities in collaboration with educational institutions and private......This book is about introducing more creativity into general educational courses and cross-disciplinary activities. It is directed toward teachers at all levels in the educational system, but the Creative Platform is a general model, and thus the creative process will fundamentally be the same...... companies. It is a project in which the goal is to make a hands-on approach to a knowledge perspective on enhancing creativity. The underlying ambition of the Creative Platform is to make it easier to promote creativity. At www.uka.aau.dk/The+Creative+Platform, you can find extra materials and instructions...

  13. National Community Solar Platform

    Energy Technology Data Exchange (ETDEWEB)

    Rupert, Bart [Clean Energy Collective, Louisville, CO (United States)

    2016-06-30

    This project was created to provide a National Community Solar Platform (NCSP) portal known as Community Solar Hub, that is available to any entity or individual who wants to develop community solar. This has been done by providing a comprehensive portal to make CEC’s solutions, and other proven community solar solutions, externally available for everyone to access – making the process easy through proven platforms to protect subscribers, developers and utilities. The successful completion of this project provides these tools via a web platform and integration APIs, a wide spectrum of community solar projects included in the platform, multiple groups of customers (utilities, EPCs, and advocates) using the platform to develop community solar, and open access to anyone interested in community solar. CEC’s Incubator project includes web-based informational resources, integrated systems for project information and billing systems, and engagement with customers and users by community solar experts. The combined effort externalizes much of Clean Energy Collective’s industry-leading expertise, allowing third parties to develop community solar without duplicating expensive start-up efforts. The availability of this platform creates community solar projects that are cheaper to build and cheaper to participate in, furthering the goals of DOE’s SunShot Initiative. Final SF 425 Final SF 428 Final DOE F 2050.11 Final Report Narrative

  14. The Platformization of the Web: Making Web Data Platform Ready

    NARCIS (Netherlands)

    A. Helmond

    2015-01-01

    In this article, I inquire into Facebook’s development as a platform by situating it within the transformation of social network sites into social media platforms. I explore this shift with a historical perspective on, what I refer to as, platformization, or the rise of the platform as the dominant

  15. Platform Performance and Challenges - using Platforms in Lego Company

    DEFF Research Database (Denmark)

    Munk, Lone; Mortensen, Niels Henrik

    2009-01-01

    by the product defining users (product developers) and platform erosion. When the platforms are not used it is due to: unsuitable calculation models, lack of goals, rewards or benefits from management, unattractive tradeoffs and difficulties in understanding the platform. This indicates that platform design...... needs focus on the incentive of using the platform. This problem lacks attention in literature, as well as industry, where assessment criteria do not cover this aspect. Therefore, we recommend including user incentive in platform assessment criteria to these challenges. Concrete solution elements...... ensuring user incentive in platforms is an object for future research...

  16. Transactional Network Platform: Applications

    Energy Technology Data Exchange (ETDEWEB)

    Katipamula, Srinivas; Lutes, Robert G.; Ngo, Hung; Underhill, Ronald M.

    2013-10-31

    In FY13, Pacific Northwest National Laboratory (PNNL) with funding from the Department of Energy’s (DOE’s) Building Technologies Office (BTO) designed, prototyped and tested a transactional network platform to support energy, operational and financial transactions between any networked entities (equipment, organizations, buildings, grid, etc.). Initially, in FY13, the concept demonstrated transactions between packaged rooftop air conditioners and heat pump units (RTUs) and the electric grid using applications or "agents" that reside on the platform, on the equipment, on a local building controller or in the Cloud. The transactional network project is a multi-lab effort with Oakridge National Laboratory (ORNL) and Lawrence Berkeley National Laboratory (LBNL) also contributing to the effort. PNNL coordinated the project and also was responsible for the development of the transactional network (TN) platform and three different applications associated with RTUs. This document describes two applications or "agents" in details, and also summarizes the platform. The TN platform details are described in another companion document.

  17. Identification of platform levels

    DEFF Research Database (Denmark)

    Mortensen, Niels Henrik

    2005-01-01

    reduction, ability to launch a wider product portfolio without increasing resources and reduction of complexity within the whole company. To support the multiple product development process, platform based product development has in many companies such as Philips, VW, Ford etc. proven to be a very effective...... because the nature of developing platforms and applications are very different. In single product development reuse is often determined by individual designers, in multiple product development reuse is to a large degree a management issue. It is difficult for a company to switch from single to multiple...... development will be examined. Based on the identification of the above characteristics five platform levels are described. The research presented in this paper is a result of MSc, Ph.D projects at the Technical University of Denmark and consultancy projects within the organisation of Institute of Product...

  18. Universal visualization platform

    Science.gov (United States)

    Gee, Alexander G.; Li, Hongli; Yu, Min; Smrtic, Mary Beth; Cvek, Urska; Goodell, Howie; Gupta, Vivek; Lawrence, Christine; Zhou, Jainping; Chiang, Chih-Hung; Grinstein, Georges G.

    2005-03-01

    Although there are a number of visualization systems to choose from when analyzing data, only a few of these allow for the integration of other visualization and analysis techniques. There are even fewer visualization toolkits and frameworks from which one can develop ones own visualization applications. Even within the research community, scientists either use what they can from the available tools or start from scratch to define a program in which they are able to develop new or modified visualization techniques and analysis algorithms. Presented here is a new general-purpose platform for constructing numerous visualization and analysis applications. The focus of this system is the design and experimentation of new techniques, and where the sharing of and integration with other tools becomes second nature. Moreover, this platform supports multiple large data sets, and the recording and visualizing of user sessions. Here we introduce the Universal Visualization Platform (UVP) as a modern data visualization and analysis system.

  19. Geostationary multipurpose platforms

    Science.gov (United States)

    Bekey, I.; Bowman, R. M.

    1981-01-01

    In addition to the advantages generally associated with orbital platforms, such as improved reliability, economies of scale, simple connectivity of elements, reduced tracking demands and the restraint of orbital object population growth, geostationary platforms yield: (1) continuous access by fixed ground antennas for communications services; (2) continuous monitoring of phenomena over chosen regions of the earth's surface; (3) a preferred location for many solar-terrestrial physics experiments. The geostationary platform also offers a low-risk and economical solution to the impending saturation of the orbital arc/frequency spectrum, maximizing the capacity of individual slots and increasing the utility of the entire arc. It also allows the use of many small, simple and inexpensive earth stations through complexity inversion and high power per beam. Block diagram and operational flowcharts are provided.

  20. Windows Azure Platform

    CERN Document Server

    Redkar, Tejaswi

    2011-01-01

    The Windows Azure Platform has rapidly established itself as one of the most sophisticated cloud computing platforms available. With Microsoft working to continually update their product and keep it at the cutting edge, the future looks bright - if you have the skills to harness it. In particular, new features such as remote desktop access, dynamic content caching and secure content delivery using SSL make the latest version of Azure a more powerful solution than ever before. It's widely agreed that cloud computing has produced a paradigm shift in traditional architectural concepts by providin

  1. Windows Azure Platform

    CERN Document Server

    Redkar, Tejaswi

    2010-01-01

    The Azure Services Platform is a brand-new cloud-computing technology from Microsoft. It is composed of four core components-Windows Azure, .NET Services, SQL Services, and Live Services-each with a unique role in the functioning of your cloud service. It is the goal of this book to show you how to use these components, both separately and together, to build flawless cloud services. At its heart Windows Azure Platform is a down-to-earth, code-centric book. This book aims to show you precisely how the components are employed and to demonstrate the techniques and best practices you need to know

  2. Wireless sensor platform

    Energy Technology Data Exchange (ETDEWEB)

    Joshi, Pooran C.; Killough, Stephen M.; Kuruganti, Phani Teja

    2017-08-08

    A wireless sensor platform and methods of manufacture are provided. The platform involves providing a plurality of wireless sensors, where each of the sensors is fabricated on flexible substrates using printing techniques and low temperature curing. Each of the sensors can include planar sensor elements and planar antennas defined using the printing and curing. Further, each of the sensors can include a communications system configured to encode the data from the sensors into a spread spectrum code sequence that is transmitted to a central computer(s) for use in monitoring an area associated with the sensors.

  3. Mobile4D platform

    CSIR Research Space (South Africa)

    Botha, Adèle

    2010-05-01

    Full Text Available . It is a communication platform that has architecture for creating, deploying and managing services and applications by integrating voice, video and data across a range of IP and telecom communication networks. In 2007, Red Hat made a firm commitment... based on the Mobicents muni ations Platform brand. 2.1.5  Telco specific User‐Generated Services   A variety of communication network operators have started initiatives to address User- Generated Services for the Telecom domain. Some...

  4. Games and Platform Decisions

    DEFF Research Database (Denmark)

    Hansen, Poul H. Kyvsgård; Mikkola, Juliana Hsuan

    2007-01-01

    is the application of on-line games in order to provide training for decision makers and in order to generate overview over the implications of platform decisions. However, games have to be placed in a context with other methods and we argue that a mixture of games, workshops, and simulations can provide improved...

  5. Creative Platform Learning (CPL)

    DEFF Research Database (Denmark)

    Christensen, Jonna Langeland; Hansen, Søren

    Creative Platform Learning (CPL) er en pædagogisk metode, der skaber foretagsomme og innovative elever, der kan anvende deres kreativitet til at lære nyt. Ifølge den nye skolereform skal Innovation og entreprenørskab tydeliggøres i alle fag. I CPL er det en integreret del af undervisningen...

  6. Games and Platform Decisions

    DEFF Research Database (Denmark)

    Hansen, Poul H. Kyvsgård; Mikkola, Juliana Hsuan

    2007-01-01

    is the application of on-line games in order to provide training for decision makers and in order to generate overview over the implications of platform decisions. However, games have to be placed in a context with other methods and we argue that a mixture of games, workshops, and simulations can provide improved...

  7. Mobile Platforms and Development Environments

    CERN Document Server

    Helal, Sumi; Li, Wengdong

    2012-01-01

    Mobile platform development has lately become a technological war zone with extremely dynamic and fluid movement, especially in the smart phone and tablet market space. This Synthesis lecture is a guide to the latest developments of the key mobile platforms that are shaping the mobile platform industry. The book covers the three currently dominant native platforms -- iOS, Android and Windows Phone -- along with the device-agnostic HTML5 mobile web platform. The lecture also covers location-based services (LBS) which can be considered as a platform in its own right. The lecture utilizes a sampl

  8. Online stock trading platform

    Directory of Open Access Journals (Sweden)

    Ion LUNGU

    2006-01-01

    Full Text Available The Internet is the perfect tool that can assure the market’s transparency for any user who wants to trade on the stock market. The investor can have access to the market news, financial calendar or the press releases of the issuers. A good online trading platform also provides real-time intraday quotes, trading history and technical analysis giving the investor a clearer view of the supply and demand in the market. All this information provides the investor a good image of the market and encourages him to trade. This paper wishes to draft the pieces of an online trading platform and to analyze the impact of developing and implementing one in a brokerage firm.

  9. Available: motorised platform

    CERN Document Server

    The COMPASS collaboration

    2014-01-01

    The COMPASS collaboration would like to offer to a new owner the following useful and fully operational piece of equipment, which is due to be replaced with better adapted equipment.   Please contact Erwin Bielert (erwin.bielert@cern.ch or 160539) for further information.  Motorized platform (FOR FREE):   Fabricated by ACL (Alfredo Cardoso & Cia Ltd) in Portugal. The model number is MeXs 5-­‐30.  Specifications: 5 m wide, 1 m deep, adjustable height (1.5 m if folded). Maximum working floor height: 4 m. conforms to CERN regulations, number LV158. Type LD500, capacity 500 kg and weight 2000 kg.  If no interested party is found before December 2014, the platform will be thrown away.

  10. Common tester platform concept.

    Energy Technology Data Exchange (ETDEWEB)

    Hurst, Michael James

    2008-05-01

    This report summarizes the results of a case study on the doctrine of a common tester platform, a concept of a standardized platform that can be applicable across the broad spectrum of testing requirements throughout the various stages of a weapons program, as well as across the various weapons programs. The common tester concept strives to define an affordable, next-generation design that will meet testing requirements with the flexibility to grow and expand; supporting the initial development stages of a weapons program through to the final production and surveillance stages. This report discusses a concept investing key leveraging technologies and operational concepts combined with prototype tester-development experiences and practical lessons learned gleaned from past weapons programs.

  11. OGC Collaborative Platform undercover

    Science.gov (United States)

    Buehler, G.; Arctur, D. K.; Bermudez, L. E.

    2012-12-01

    The mission of the Open Geospatial Consortium (OGC) is to serve as a global forum for the collaboration of developers and users of spatial data products and services, and to advance the development of international standards for geospatial interoperability. The OGC coordinates with over 400 institutions in the development of geospatial standards. OGC has a dedicated staff supported by a Collaborative Web Platform to enable sophisticated and successful coordination among its members. Since its origins in the early 1990s, the OGC Collaborative Web Platform has evolved organically to be the collaboration hub for standards development in the exchange of geospatial and related types of information, among a global network of thousands of technical, scientific and management professionals spanning numerous disparate application domains. This presentation describes the structure of this collaboration hub, the relationships enabled (both among and beyond OGC members), and how this network fits in a broader ecosystem of technology development and information standards organizations.

  12. Video analysis platform

    OpenAIRE

    FLORES, Pablo; Arias, Pablo; Lecumberry, Federico; Pardo, Álvaro

    2006-01-01

    In this article we present the Video Analysis Platform (VAP) which is an open source software framework for video analysis, processing and description. The main goals of VAP are: to provide a multiplatform system which allows the easy implementation of video algorithms, provide structures and algorithms for the segmentation of video data in its different levels of abstraction: shots, frames, objects, regions, etc, permit the generation and comparison of MPEG7-like descriptors, and develop tes...

  13. Cloud Robotics Platforms

    Directory of Open Access Journals (Sweden)

    Busra Koken

    2015-01-01

    Full Text Available Cloud robotics is a rapidly evolving field that allows robots to offload computation-intensive and storage-intensive jobs into the cloud. Robots are limited in terms of computational capacity, memory and storage. Cloud provides unlimited computation power, memory, storage and especially collaboration opportunity. Cloud-enabled robots are divided into two categories as standalone and networked robots. This article surveys cloud robotic platforms, standalone and networked robotic works such as grasping, simultaneous localization and mapping (SLAM and monitoring.

  14. HPC - Platforms Penta Chart

    Energy Technology Data Exchange (ETDEWEB)

    Trujillo, Angelina Michelle [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-10-08

    Strategy, Planning, Acquiring- very large scale computing platforms come and go and planning for immensely scalable machines often precedes actual procurement by 3 years. Procurement can be another year or more. Integration- After Acquisition, machines must be integrated into the computing environments at LANL. Connection to scalable storage via large scale storage networking, assuring correct and secure operations. Management and Utilization – Ongoing operations, maintenance, and trouble shooting of the hardware and systems software at massive scale is required.

  15. IP Rights and Technological Platforms

    OpenAIRE

    Robert P. Merges

    2008-01-01

    This paper is about intellectual property rights (IPRs) and platform technologies. After a brief introduction explaining some basics of networks, standards and platforms, I turn to three policy issues. The first is the role of IP in what might be termed platform policies, the decisions by courts and regulators concerning whether and how to promote multi-party access to important digital platforms such as media player hardware, cell phones, PCs, and the like. I argue that for the most part the...

  16. "Platform switching": Serendipity

    Directory of Open Access Journals (Sweden)

    N Kalavathy

    2014-01-01

    Full Text Available Implant dentistry is the latest developing field in terms of clinical techniques, research, material science and oral rehabilitation. Extensive work is being done to improve the designing of implants in order to achieve better esthetics and function. The main drawback with respect to implant restoration is achieving good osseointegration along with satisfactory stress distribution, which in turn will improve the prognosis of implant prosthesis by reducing the crestal bone loss. Many concepts have been developed with reference to surface coating of implants, surgical techniques for implant placement, immediate and delayed loading, platform switching concept, etc. This article has made an attempt to review the concept of platform switching was in fact revealed accidentally due to the nonavailability of the abutment appropriate to the size of the implant placed. A few aspect of platform switching, an upcoming idea to reduce crestal bone loss have been covered. The various methods used for locating and preparing the data were done through textbooks, Google search and related articles.

  17. "Platform switching": serendipity.

    Science.gov (United States)

    Kalavathy, N; Sridevi, J; Gehlot, Roshni; Kumar, Santosh

    2014-01-01

    Implant dentistry is the latest developing field in terms of clinical techniques, research, material science and oral rehabilitation. Extensive work is being done to improve the designing of implants in order to achieve better esthetics and function. The main drawback with respect to implant restoration is achieving good osseointegration along with satisfactory stress distribution, which in turn will improve the prognosis of implant prosthesis by reducing the crestal bone loss. Many concepts have been developed with reference to surface coating of implants, surgical techniques for implant placement, immediate and delayed loading, platform switching concept, etc. This article has made an attempt to review the concept of platform switching was in fact revealed accidentally due to the nonavailability of the abutment appropriate to the size of the implant placed. A few aspect of platform switching, an upcoming idea to reduce crestal bone loss have been covered. The various methods used for locating and preparing the data were done through textbooks, Google search and related articles.

  18. The Prodiguer Messaging Platform

    Science.gov (United States)

    Denvil, S.; Greenslade, M. A.; Carenton, N.; Levavasseur, G.; Raciazek, J.

    2015-12-01

    CONVERGENCE is a French multi-partner national project designed to gather HPC and informatics expertise to innovate in the context of running French global climate models with differing grids and at differing resolutions. Efficient and reliable execution of these models and the management and dissemination of model output are some of the complexities that CONVERGENCE aims to resolve.At any one moment in time, researchers affiliated with the Institut Pierre Simon Laplace (IPSL) climate modeling group, are running hundreds of global climate simulations. These simulations execute upon a heterogeneous set of French High Performance Computing (HPC) environments. The IPSL's simulation execution runtime libIGCM (library for IPSL Global Climate Modeling group) has recently been enhanced so as to support hitherto impossible realtime use cases such as simulation monitoring, data publication, metrics collection, simulation control, visualizations … etc. At the core of this enhancement is Prodiguer: an AMQP (Advanced Message Queue Protocol) based event driven asynchronous distributed messaging platform. libIGCM now dispatches copious amounts of information, in the form of messages, to the platform for remote processing by Prodiguer software agents at IPSL servers in Paris. Such processing takes several forms: Persisting message content to database(s); Launching rollback jobs upon simulation failure; Notifying downstream applications; Automation of visualization pipelines; We will describe and/or demonstrate the platform's: Technical implementation; Inherent ease of scalability; Inherent adaptiveness in respect to supervising simulations; Web portal receiving simulation notifications in realtime.

  19. Don't always blame the photons: Relationships between deprotection blur, LER, and shot noise in EUV photoresists

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, Christopher N.; Naulleau, Patrick P.

    2008-06-02

    A corner rounding metric has been used to determine the deprotection blur of Rohm and Haas XP 5435, XP 5271, and XP 5496 extreme ultraviolet (EUV) photoresists as base weight percent is varied; an experimental open platform photoresist (EH27) as base weight percent is varied; and TOK EUVR P1123 and FUJI 1195 photoresists as post-exposure bake (PEB) temperature is varied. In the XP 5435, XP 5271, XP 5496, and EH27 resist platforms, a 6 times increase in base weight percent reduces the size of successfully patterned 1:1 lines by over 10 nm and lowers intrinsic line-edge roughness (LER) by over 2.5 nm without changing deprotection blur. In TOK EUVR P1123 photoresist, lowering the PEB temperature from 100 C to 80 C reduces measured deprotection blur (using the corner metric) from 30 nm to 20 nm and reduces the LER of 50 nm 1:1 lines from 4.8 nm to 4.3 nm. These data are used to drive a lengthy discussion about the relationships between deprotection blur, LER, and shot noise in EUV photoresists. We provide two separate conclusions: (1) shot noise is probably not the dominant mechanism causing the 3-4 nm EUV LER floor that has been observed over the past several years; (2) chemical contrast contributes to LER whenever deprotection blur is large relative to the printed half pitch.

  20. Platform computing powers enterprise grid

    CERN Multimedia

    2002-01-01

    Platform Computing, today announced that the Stanford Linear Accelerator Center is using Platform LSF 5, to carry out groundbreaking research into the origins of the universe. Platform LSF 5 will deliver the mammoth computing power that SLAC's Linear Accelerator needs to process the data associated with intense high-energy physics research (1 page).

  1. The Geohazards Exploitation Platform

    Science.gov (United States)

    Laur, Henri; Casu, Francesco; Bally, Philippe; Caumont, Hervé; Pinto, Salvatore

    2016-04-01

    The Geohazards Exploitation Platform, or Geohazards TEP (GEP), is an ESA originated R&D activity of the EO ground segment to demonstrate the benefit of new technologies for large scale processing of EO data. This encompasses on-demand processing for specific user needs, systematic processing to address common information needs of the geohazards community, and integration of newly developed processors for scientists and other expert users. The platform supports the geohazards community's objectives as defined in the context of the International Forum on Satellite EO and Geohazards organised by ESA and GEO in Santorini in 2012. The GEP is a follow on to the Supersites Exploitation Platform (SSEP) an ESA initiative to support the Geohazards Supersites & Natural Laboratories initiative (GSNL). Today the GEP allows to exploit 70+ Terabyte of ERS and ENVISAT archive and the Copernicus Sentinel-1 data available on line. The platform has already engaged 22 European early adopters in a validation activity initiated in March 2015. Since September, this validation has reached 29 single user projects. Each project is concerned with either integrating an application, running on demand processing or systematically generating a product collection using an application available in the platform. The users primarily include 15 geoscience centres and universities based in Europe: British Geological Survey (UK), University of Leeds (UK), University College London (UK), ETH University of Zurich (CH), INGV (IT), CNR-IREA and CNR-IRPI (IT), University of L'Aquila (IT), NOA (GR), Univ. Blaise Pascal & CNRS (FR), Ecole Normale Supérieure (FR), ISTERRE / University of Grenoble-Alpes (FR). In addition, there are users from Africa and North America with the University of Rabat (MA) and the University of Miami (US). Furthermore two space agencies and four private companies are involved: the German Space Research Centre DLR (DE), the European Space Agency (ESA), Altamira Information (ES

  2. Identification of platform levels

    DEFF Research Database (Denmark)

    Mortensen, Niels Henrik

    2005-01-01

    reduction, ability to launch a wider product portfolio without increasing resources and reduction of complexity within the whole company. To support the multiple product development process, platform based product development has in many companies such as Philips, VW, Ford etc. proven to be a very effective...... and efficient tool. Transforming product development from single to multiple product development is a significant change in product development often involving major changes of product models, procedures and organization. In the area of product models a set of new models has to be introduced, e.g. models...

  3. Cots Correlator Platform

    Science.gov (United States)

    Schaaf, Kjeld; Overeem, Ruud

    2004-06-01

    Moore’s law is best exploited by using consumer market hardware. In particular, the gaming industry pushes the limit of processor performance thus reducing the cost per raw flop even faster than Moore’s law predicts. Next to the cost benefits of Common-Of-The-Shelf (COTS) processing resources, there is a rapidly growing experience pool in cluster based processing. The typical Beowulf cluster of PC’s supercomputers are well known. Multiple examples exists of specialised cluster computers based on more advanced server nodes or even gaming stations. All these cluster machines build upon the same knowledge about cluster software management, scheduling, middleware libraries and mathematical libraries. In this study, we have integrated COTS processing resources and cluster nodes into a very high performance processing platform suitable for streaming data applications, in particular to implement a correlator. The required processing power for the correlator in modern radio telescopes is in the range of the larger supercomputers, which motivates the usage of supercomputer technology. Raw processing power is provided by graphical processors and is combined with an Infiniband host bus adapter with integrated data stream handling logic. With this processing platform a scalable correlator can be built with continuously growing processing power at consumer market prices.

  4. Feasibility of a simple microsieve-based immunoassay platform

    NARCIS (Netherlands)

    Zweitzig, D.R.; Tibbe, Arjan G.J.; Nguyen, A.T.; van Rijn, C.J.M.; Kopnitsky, M.J.; Cichonski, K.; Terstappen, Leonardus Wendelinus Mathias Marie

    2016-01-01

    The intrinsic properties of silicon microsieves, such as an optically flat surface, high overall porosity, and low flow resistance have led to an increasing number of biotechnology applications. In this report, the feasibility of creating a microsieve-based immunoassay platform was explored. Microsi

  5. Feasibility of a simple microsieve-based immunoassay platform

    NARCIS (Netherlands)

    Zweitzig, Daniel R.; Tibbe, Arjan G.; Nguyen, Ai T.; Rijn, van Cees J.M.; Kopnitsky, Mark J.; Cichonski, Kathleen; Terstappen, Leon W.M.M.

    2016-01-01

    The intrinsic properties of silicon microsieves, such as an optically flat surface, high overall porosity, and low flow resistance have led to an increasing number of biotechnology applications. In this report, the feasibility of creating a microsieve-based immunoassay platform was explored. Micr

  6. Communications payloads for geostationary platforms

    Science.gov (United States)

    Fordyce, S. W.

    1978-01-01

    Trends in communication satellites show increasing reuse of the frequency spectrum through multiple spot beams and orthogonal polarization, as well as consortia operation. Current reliance on orbital arc separation for frequency reuse may be inadequate for the projected traffic growth and the orbital slotting proposals before the ITU. This paper notes that cost advantages can accrue through common use of spacecraft subsystems and multiple users' platforms aboard a common geostationary platform. The rationale for such platforms is described and potential payloads are suggested.

  7. Utilizing platforms in industrialized construction

    DEFF Research Database (Denmark)

    Bonev, Martin; Wörösch, Michael; Hvam, Lars

    2015-01-01

    construction companies. A promising approach adapted by operations management and design theory regards individual building projects as the adjustment and recombination of components and processes from a set of predefined platforms, while configuration systems assure feasible building solutions. Design...... methods map structural platform characteristics so as to balance commonality and distinctiveness. Originality/value – This paper proposes a general theory of platform-based development and execution in the industrialised construction sector, which goes beyond concurrent approaches of standardising...

  8. Web Platform Application

    Energy Technology Data Exchange (ETDEWEB)

    Paulsworth, Ashley [Sunvestment Group, Frederick, MD (United States); Kurtz, Jim [Sunvestment Group, Frederick, MD (United States); Brun de Pontet, Stephanie [Sunvestment Group, Frederick, MD (United States)

    2016-06-15

    Sunvestment Energy Group (previously called Sunvestment Group) was established to create a web application that brings together site hosts, those who will obtain the energy from the solar array, with project developers and funders, including affinity investors. Sunvestment Energy Group (SEG) uses a community-based model that engages with investors who have some affinity with the site host organization. In addition to a financial return, these investors receive non-financial value from their investments and are therefore willing to offer lower cost capital. This enables the site host to enjoy more savings from solar through these less expensive Community Power Purchase Agreements (CPPAs). The purpose of this award was to develop an online platform to bring site hosts and investors together virtually.

  9. Energy Tracking Software Platform

    Energy Technology Data Exchange (ETDEWEB)

    Ryan Davis; Nathan Bird; Rebecca Birx; Hal Knowles

    2011-04-04

    Acceleration has created an interactive energy tracking and visualization platform that supports decreasing electric, water, and gas usage. Homeowners have access to tools that allow them to gauge their use and track progress toward a smaller energy footprint. Real estate agents have access to consumption data, allowing for sharing a comparison with potential home buyers. Home builders have the opportunity to compare their neighborhood's energy efficiency with competitors. Home energy raters have a tool for gauging the progress of their clients after efficiency changes. And, social groups are able to help encourage members to reduce their energy bills and help their environment. EnergyIT.com is the business umbrella for all energy tracking solutions and is designed to provide information about our energy tracking software and promote sales. CompareAndConserve.com (Gainesville-Green.com) helps homeowners conserve energy through education and competition. ToolsForTenants.com helps renters factor energy usage into their housing decisions.

  10. The Creative Soccer Platform

    DEFF Research Database (Denmark)

    Johan Torp Rasmussen, Ludvig; Østergaard, Lars Domino

    2016-01-01

    Creativity is essential in soccer due to the unpredictable and complex situations occurring in the game, where stereotypical play gradually loses its efficiency. Further, creativity is an important psychological factor for the development of soccer expertise, and valuing creativity increases...... satisfaction and well-being. Although creative players are highly desired by coaches, the subject of cultivating creativity is mostly ignored and traditional training settings may even hamper the players' creativity. The purpose of this article is to introduce a novel approach for enhancing soccer players......' creativity, The Creative Soccer Platform (TCSP), and to demonstrate the implications of applying it in youth soccer practice, by means of soccer-specific creativity exercises. TCSP encompasses four theoretically based didactic principles (task focus, parallel thinking, horizontal thinking, and no experienced...

  11. Power Quality Indices Estimation Platform

    Directory of Open Access Journals (Sweden)

    Eliana I. Arango-Zuluaga

    2013-11-01

    Full Text Available An interactive platform for estimating the quality indices in single phase electric power systems is presented. It meets the IEEE 1459-2010 standard recommendations. The platform was developed in order to support teaching and research activities in electric power quality. The platform estimates the power quality indices from voltage and current signals using three different algorithms based on fast Fourier transform (FFT, wavelet packet transform (WPT and least squares method. The results show that the algorithms implemented are efficient for estimating the quality indices of the power and the platform can be used according to the objectives established. 

  12. Flexible experimental FPGA based platform

    DEFF Research Database (Denmark)

    Andersen, Karsten Holm; Nymand, Morten

    2016-01-01

    This paper presents an experimental flexible Field Programmable Gate Array (FPGA) based platform for testing and verifying digital controlled dc-dc converters. The platform supports different types of control strategies, dc-dc converter topologies and switching frequencies. The controller platform...... interface supporting configuration and reading of setup parameters, controller status and the acquisition memory in a simple way. The FPGA based platform, provides an easy way within education or research to use different digital control strategies and different converter topologies controlled by an FPGA...

  13. Product Platform Screening at LEGO

    DEFF Research Database (Denmark)

    Mortensen, Niels Henrik; Steen Jensen, Thomas; Nielsen, Ole Fiil

    2012-01-01

    Product platforms offer great benefits to companies developing new products in highly competitive markets. Literature describes how a single platform can be designed from a technical point of view, but rarely mentions how the process begins. How do companies identify possible platform candidates...... after a few changes had been applied to the initial process layout. This case study shows how companies must focus on a limited selection of simultaneous projects in order to keep focus. Primary stakeholders must be involved from the very beginning, and short presentations of the platform concepts...

  14. Platform evolution studies

    Science.gov (United States)

    Walton, Barbara A.

    1990-01-01

    The polar orbiting platform (POP), being developed by the Work Package 3 (WP3) Project at the Goddard Space Flight Center, will play a key role in the NASA Leadership Initiative, Mission to Planet Earth (MPE). It becomes, with the addition of payloads, an Earth observation satellite observatory. Mission to Planet Earth also has geostationary platforms (GEOP) as part of its global observational system. A study was begun in March 1988 to assess the applicability of the POP orbital replacement units (ORUs) for a geostationary Earth observing mission. Two test cases, representative of MPE payloads, were studied. Case A was used to emphasize the GEOP configuration and design; it used a Titan/Centaur to achieve orbit. Case B, considered to be much further in the future, included some assembly at the Space Station Freedom manned base and use of an orbital transfer vehicle to achieve orbit; requirements on the manned base to support such a mission were emphasized. The study found the POP systems more than adequate to meet GEOP requirements. Two types of changes were required for the POP ORUs: (1) modification to use only one surface for heat rejection; for the battery ORU, this meant 'opening up' the ORU to retain the radiator area with a corresponding decrease in depth; and (2) deletion of equipment not needed. The Case A configuration was shown to be within the planned capability of the Titan IV/Centaur. Assembly requirements were included for the Case B configuration, which is driven by the large microwave antennas of two of the payloads. The final review was April 19, 1989.

  15. Platform Performance and Challenges - using Platforms in Lego Company

    DEFF Research Database (Denmark)

    Munk, Lone; Mortensen, Niels Henrik

    2009-01-01

    This article studies the performance and challenges of using nine implemented product platforms in LEGO Company. Most of these do produce results, but do not meet their goals due to challenges in their usage in the daily product. The main challenges are that the platforms are not being used...

  16. Position measurement/tracking comparison of the instrumentation in a droplet-actuated-robotic platform.

    Science.gov (United States)

    Casier, Renaud; Lenders, Cyrille; Lhernould, Marion Sausse; Gauthier, Michaël; Lambert, Pierre

    2013-05-07

    This paper reports our work on developing a surface tension actuated micro-robotic platform supported by three bubbles (liquid environment) or droplets (gaseous environment). The actuation principle relies on the force developed by surface tension below a millimeter, which benefits from scaling laws, and is used to actuate this new type of compliant robot. By separately controlling the pressure inside each bubble, three degrees of freedom can be actuated. We investigated three sensing solutions to measure the platform attitude in real-time (z-position of each droplet, leading to the knowledge of the z position and Θx and Θy tilts of the platform). The comparison between optical, resistive, and capacitive measurement principles is hereafter reported. The optical technique uses SFH-9201 components. The resistive technique involves measuring the electrical resistance of a path flowing through two droplets and the platform. This innovative technique for sensing table position combines three pairs of resistances, from which the resistance in each drop can be deduced, thus determining the platform position. The third solution is a more usual high frequency (~200 MHz) capacitive measurement. The resistive method has been proven reliable and is simple to implement. This work opens perspectives toward an interesting sensing solution for micro-robotic platforms.

  17. Position Measurement/Tracking Comparison of the Instrumentation in a Droplet-Actuated-Robotic Platform

    Directory of Open Access Journals (Sweden)

    Pierre Lambert

    2013-05-01

    Full Text Available This paper reports our work on developing a surface tension actuated micro-robotic platform supported by three bubbles (liquid environment or droplets (gaseous environment. The actuation principle relies on the force developed by surface tension below a millimeter, which benefits from scaling laws, and is used to actuate this new type of compliant robot. By separately controlling the pressure inside each bubble, three degrees of freedom can be actuated. We investigated three sensing solutions to measure the platform attitude in real-time (z-position of each droplet, leading to the knowledge of the z position and Θx and Θy tilts of the platform. The comparison between optical, resistive, and capacitive measurement principles is hereafter reported. The optical technique uses SFH-9201 components. The resistive technique involves measuring the electrical resistance of a path flowing through two droplets and the platform. This innovative technique for sensing table position combines three pairs of resistances, from which the resistance in each drop can be deduced, thus determining the platform position. The third solution is a more usual high frequency (~200 MHz capacitive measurement. The resistive method has been proven reliable and is simple to implement. This work opens perspectives toward an interesting sensing solution for micro-robotic platforms.

  18. Rapid prototyping of robotic platforms

    CSIR Research Space (South Africa)

    De Ronde, Willis

    2016-11-01

    Full Text Available Building a robotic platform from raw materials can take anything from a few weeks to a few years to complete, depending on the complexity and size of the platform. This paper aims to introduce a novel approach of using abrasive waterjet machining...

  19. Preparing for a Product Platform

    DEFF Research Database (Denmark)

    Fiil-Nielsen, Ole; Munk, Lone; Mortensen, Niels Henrik

    2005-01-01

    they lead to increased sales due to more customized product as well as decreased costs due to reuse, making a product development platform a very profitable strategy for product developing companies. A successful implementation of a product development platform is not straightforward though...

  20. Product Platform Screening at LEGO

    DEFF Research Database (Denmark)

    Mortensen, Niels Henrik; Steen Jensen, Thomas; Nielsen, Ole Fiil

    2012-01-01

    Product platforms offer great benefits to companies developing new products in highly competitive markets. Literature describes how a single platform can be designed from a technical point of view, but rarely mentions how the process begins. How do companies identify possible platform candidates......, and how do they assess if these candidates have enough potential to be worth implementing? Danish toy manufacturer LEGO has systematically gone through this process twice. The first time the results were poor; almost all platform candidates failed. The second time, though, has been largely successful...... after a few changes had been applied to the initial process layout. This case study shows how companies must focus on a limited selection of simultaneous projects in order to keep focus. Primary stakeholders must be involved from the very beginning, and short presentations of the platform concepts...

  1. ADAPTABLE ALTERNATE REALITY GAMES PLATFORM

    Directory of Open Access Journals (Sweden)

    Liviu-Adrian Cotfas

    2013-12-01

    Full Text Available In this paper, we present an alternate reality games platform that facilitates the creation of ARG projects with different themes and sizes. The platform is well integrated with the most important social media networks, thus facilitating both the involvement of the public and the creation of a more engaging interaction for the participants. A cloud-based architecture was used in order to allow the platform to easily accommodate projects of various sizes and to provide a good level of scalability. The platform is fully localizable in any language and multiple languages can be used at once to create projects that target users from different countries. An initial project that uses gamification to create an immersive learning environment has been created around the developed platform. The project combines professional and public feedback in order to provide an enhanced learning experience.

  2. Plat_Forms -- a contest: The web development platform comparison

    CERN Document Server

    Prechelt, Lutz

    2008-01-01

    "Plat_Forms" is a competition in which top-class teams of three programmers compete to implement the same requirements for a web-based system within 30 hours, each team using a different technology platform (Java EE, .NET, PHP, Perl, Python, or Ruby on Rails). The results will provide new insights into the real (rather than purported) pros, cons, and emergent properties of each platform. The evaluation will analyze many aspects of each solution, both external (usability, functionality, reliability, performance, etc.) and internal (structure, understandability, flexibility, etc.).

  3. Platform projections, compilers, interpreters and portability

    NARCIS (Netherlands)

    Bergstra, J.A.; Loots, M.E.

    1999-01-01

    Platform projection semantics extends projection semantics by means of the encapsulation of a processor used for program execution. Platform projection semantics abstracts from platform specific details. For a given program its platform projection semantics may be platform-independent. Two forms

  4. Vertical Relationships within Platform Marketplaces

    Directory of Open Access Journals (Sweden)

    Mark J. Tremblay

    2016-07-01

    Full Text Available In two-sided markets a platform allows consumers and sellers to interact by creating sub-markets within the platform marketplace. For example, Amazon has sub-markets for all of the different product categories available on its site, and smartphones have sub-markets for different types of applications (gaming apps, weather apps, map apps, ridesharing apps, etc.. The network benefits between consumers and sellers depend on the mode of competition within the sub-markets: more competition between sellers lowers product prices, increases the surplus consumers receive from a sub-market, and makes platform membership more desirable for consumers. However, more competition also lowers profits for a seller which makes platform membership less desirable for a seller and reduces seller entry and the number of sub-markets available on the platform marketplace. This dynamic between seller competition within a sub-market and agents’ network benefits leads to platform pricing strategies, participation decisions by consumers and sellers, and welfare results that depend on the mode of competition. Thus, the sub-market structure is important when investigating platform marketplaces.

  5. Platform decisions supported by gaming

    DEFF Research Database (Denmark)

    Hansen, Poul H. Kyvsgård; Mikkola, Juliana Hsuan

    2007-01-01

    Platform is an ambiguous multidisciplinary concept. The philosophy behind it is easy to communicate and makes intuitively sense. However, the ease in communication does overshadow the high complexity when the concept is implemented. The practical industrial platform implementation challenge can...... is the application of on-line games in order to provide training for decision makers and in order to generate overview over the implications of platform decisions. However, games have to be placed in a context with other methods and we argue that a mixture of games, workshops, and simulations can provide improved...

  6. Component Reliability Assessment of Offshore Jacket Platforms

    Directory of Open Access Journals (Sweden)

    V.J. Kurian

    2015-01-01

    Full Text Available Oil and gas industry is one of the most important industries contributing to the Malaysian economy. To extract hydrocarbons, various types of production platforms have been developed. Fixed jacket platform is the earliest type of production structure, widely installed in Malaysia’s shallow and intermediate waters. To date, more than 60% of these jacket platforms have operated exceeding their initial design life, thus making the re-evaluation and reassessment necessary for these platforms to continue to be put in service. In normal engineering practice, system reliability of a structure is evaluated as its safety parameter. This method is however, much complicated and time consuming. Assessing component's reliability can be an alternative approach to provide assurance about a structure’s condition in an early stage. Design codes such as the Working Stress Design (WSD and the Load and Resistance Factor Design (LRFD are well established for the component-level assessment. In reliability analysis, failure function, which consists of strength and load, is used to define the failure event. If the load acting exceeds the capacity of a structure, the structure will fail. Calculation of stress utilization ratio as given in the design codes is able to predict the reliability of a member and to estimate the extent to which a member is being utilised. The basic idea of this ratio is that if it is more than one, the member has failed and vice versa. Stress utilization ratio is a ratio of applied stress, which is the output reaction of environmental loadings acting on the structural member, to the design strength that comes from the member’s geometric and material properties. Adopting this ratio as the failure event, the reliability of each component is found. This study reviews and discusses the reliability for selected members of three Malaysian offshore jacket platforms. First Order Reliability Method (FORM was used to generate reliability index and

  7. Influence of base and PAG on deprotection blur in EUV photoresists and some thoughts on shot noise

    Energy Technology Data Exchange (ETDEWEB)

    Jones, Juanita; Anderson, Christopher; Naulleau, Patrick; Niakoula, Demitra; Hassanein, Elsayed; Brainard, Robert; Gallatin, Gregg; Dean, Kim

    2008-06-01

    A contact-hole deprotection blur metric has been used to monitor the deprotection blur of an experimental open platform resist (EH27) as the weight percent of base and photo acid generator (PAG) were varied. Patterning ability in 1:1 line-space patterns is shown to improve at smaller pitches as base/PAG are increased however no significant change in deprotection blur was observed. Isolated (or intrinsic) line-edge-roughness (LER) is shown to improve with increased base loading while remaining fixed through PAG loading. A discussion of improved patterning performance as related to shot noise and deprotection blur concludes with a speculation that the spatial distribution of PAG molecules has been playing some role, perhaps a dominant one, in determining the uniformity of photo generated acids in the resists that have been studied.

  8. NASA's geostationary communications platform program

    Science.gov (United States)

    Ramler, J.; Durrett, R.

    1984-01-01

    This paper reviews recent trends in communications satellites and explains NASA's current interest in geostationary communications platforms. Large communications platforms capable of supporting multiple payloads with common utilities have been examined in a number of studies since 1974 and appear to offer a number of potential advantages. In 1981, an Industry Briefing and Workshop sponsord by NASA focused on the institutional, operational and technical issues that will influence the implementation of geostationary platforms. The workshop identified numerous issues and problem areas that needed more detailed study. To address the issues/problems identified, a NASA geostationary communications platform program has been developed. This program is described, focusing on the initial studies to be performed.

  9. Platform attitude data acquisition system

    Digital Repository Service at National Institute of Oceanography (India)

    Afzulpurkar, S.

    A system for automatic acquisition of underwater platform attitude data has been designed, developed and tested in the laboratory. This is a micro controller based system interfacing dual axis inclinometer, high-resolution digital compass...

  10. Elevated Fixed Platform Test Facility

    Data.gov (United States)

    Federal Laboratory Consortium — The Elevated Fixed Platform (EFP) is a helicopter recovery test facility located at Lakehurst, NJ. It consists of a 60 by 85 foot steel and concrete deck built atop...

  11. Platforms for Innovation and Internationalization

    DEFF Research Database (Denmark)

    Rasmussen, Erik Stavnsager; Petersen, Nicolaj Hannesbo

    2017-01-01

    The high-tech global startup has many challenges related to both innovation and internationalization. From a Danish cluster of Welfare Tech firms, eight innovative and international firms were selected and interviewed. Such firms typically have to be agile and operate in virtual networks in almost...... all parts of their value chains. This article contributes to the understanding of how innovation and internationalization to a great extent are interlinked. The firms have developed a core product or service offering, which the firms often describe as “a platform”. Around the platform, they develop...... their products and services for new customers and users in new countries. The firms have to sustain a strong focus on the platform while at the same time developing their platform solution for new products, new customers, and new markets. This pivoting makes it possible to use the platform in a new context...

  12. Disentangling Competition Among Platform Driven Strategic Groups

    DEFF Research Database (Denmark)

    Kazan, Erol; Tan, Chee-Wee; Lim, Eric

    2015-01-01

    In platform-driven markets, competitive advantage is derived from superior platform design and configurations. For this reason, platform owners strive to create unique and inimitable platform configurals to maintain and extend their competitiveness within network economies. To disentangle firm...... competition within platform-driven markets, we opted for the UK mobile payment market as our empirical setting. By embracing the theoretical lens of strategic groups and digital platforms, this study supplements prior research by deriving a taxonomy of platform-driven strategic groups that is grounded...... on competitive attributes of platform- driven markets; namely interfirm modularity and strategic linkages....

  13. Disentangling Competition Among Platform Driven Strategic Groups

    DEFF Research Database (Denmark)

    Kazan, Erol; Tan, Chee-Wee; Lim, Eric

    2015-01-01

    competition within platform-driven markets, we opted for the UK mobile payment market as our empirical setting. By embracing the theoretical lens of strategic groups and digital platforms, this study supplements prior research by deriving a taxonomy of platform-driven strategic groups that is grounded......In platform-driven markets, competitive advantage is derived from superior platform design and configurations. For this reason, platform owners strive to create unique and inimitable platform configurals to maintain and extend their competitiveness within network economies. To disentangle firm...... on competitive attributes of platform- driven markets; namely interfirm modularity and strategic linkages....

  14. Resistance-resistant antibiotics.

    Science.gov (United States)

    Oldfield, Eric; Feng, Xinxin

    2014-12-01

    New antibiotics are needed because drug resistance is increasing while the introduction of new antibiotics is decreasing. We discuss here six possible approaches to develop 'resistance-resistant' antibiotics. First, multitarget inhibitors in which a single compound inhibits more than one target may be easier to develop than conventional combination therapies with two new drugs. Second, inhibiting multiple targets in the same metabolic pathway is expected to be an effective strategy owing to synergy. Third, discovering multiple-target inhibitors should be possible by using sequential virtual screening. Fourth, repurposing existing drugs can lead to combinations of multitarget therapeutics. Fifth, targets need not be proteins. Sixth, inhibiting virulence factor formation and boosting innate immunity may also lead to decreased susceptibility to resistance. Although it is not possible to eliminate resistance, the approaches reviewed here offer several possibilities for reducing the effects of mutations and, in some cases, suggest that sensitivity to existing antibiotics may be restored in otherwise drug-resistant organisms.

  15. A Typology of Multi-sided Platforms

    DEFF Research Database (Denmark)

    Staykova, Kalina Stefanova; Damsgaard, Jan

    2015-01-01

    exemplary cases which allow us to illustrate the platform heterogeneity and to support new MSPs typology. As examples we include a physical two-sided platform (Gatwick Airport) that adds a third side, a digital one-sided platform transformed into being two-sided (Pingit) and a digital one-sided platform......In this paper we address how the composition of a platform impacts the platform’s business model. By platform’s business model we mean platform features, platform architecture and platform governance. To this end, we construct the Platform Business Model Framework. We apply the framework to three...... in several configurations. The particular platform architecture can explain the difficulties in designing a viable business models for platforms....

  16. A Droplet Microfluidic Platform for Automating Genetic Engineering.

    Science.gov (United States)

    Gach, Philip C; Shih, Steve C C; Sustarich, Jess; Keasling, Jay D; Hillson, Nathan J; Adams, Paul D; Singh, Anup K

    2016-05-20

    We present a water-in-oil droplet microfluidic platform for transformation, culture and expression of recombinant proteins in multiple host organisms including bacteria, yeast and fungi. The platform consists of a hybrid digital microfluidic/channel-based droplet chip with integrated temperature control to allow complete automation and integration of plasmid addition, heat-shock transformation, addition of selection medium, culture, and protein expression. The microfluidic format permitted significant reduction in consumption (100-fold) of expensive reagents such as DNA and enzymes compared to the benchtop method. The chip contains a channel to continuously replenish oil to the culture chamber to provide a fresh supply of oxygen to the cells for long-term (∼5 days) cell culture. The flow channel also replenished oil lost to evaporation and increased the number of droplets that could be processed and cultured. The platform was validated by transforming several plasmids into Escherichia coli including plasmids containing genes for fluorescent proteins GFP, BFP and RFP; plasmids with selectable markers for ampicillin or kanamycin resistance; and a Golden Gate DNA assembly reaction. We also demonstrate the applicability of this platform for transformation in widely used eukaryotic organisms such as Saccharomyces cerevisiae and Aspergillus niger. Duration and temperatures of the microfluidic heat-shock procedures were optimized to yield transformation efficiencies comparable to those obtained by benchtop methods with a throughput up to 6 droplets/min. The proposed platform offers potential for automation of molecular biology experiments significantly reducing cost, time and variability while improving throughput.

  17. Stratifying the Develoment of Product Platforms

    DEFF Research Database (Denmark)

    Sköld, Martin; Karlsson, Christer

    2013-01-01

    companies develop platforms for different aims, purposes, and product scopes. Following on from this, the requirements for platform development resources, the ways of organizing platform development, and the implications for management styles have not been explored and are presumably varying. To start...... influencing the project length, requirements for platform development resources, principles for organizing, and implications for management styles....

  18. New offshore platform in the Mexican Gulf

    Energy Technology Data Exchange (ETDEWEB)

    Beisel, T.

    1982-04-01

    After a construction period of only 10 months, the second steel Offshore platform was recently completed in the Mexican Gulf. The pattern for this structure was the Cognac platform. The erection of the new platform, called the 'Cerveza' platform, is described in the article.

  19. Centrifuge-Based Fluidic Platforms

    Science.gov (United States)

    Zoval, Jim; Jia, Guangyao; Kido, Horacio; Kim, Jitae; Kim, Nahui; Madou, Marc

    In this chapter centrifuge-based microfluidic platforms are reviewed and compared with other popular microfluidic propulsion methods. The underlying physical principles of centrifugal pumping in microfluidic systems are presented and the various centrifuge fluidic functions such as valving, decanting, calibration, mixing, metering, heating, sample splitting, and separation are introduced. Those fluidic functions have been combined with analytical measurements techniques such as optical imaging, absorbance and fluorescence spectroscopy and mass spectrometry to make the centrifugal platform a powerful solution for medical and clinical diagnostics and high-throughput screening (HTS) in drug discovery. Applications of a compact disc (CD)-based centrifuge platform analyzed in this review include: two-point calibration of an optode-based ion sensor, an automated immunoassay platform, multiple parallel screening assays and cellular-based assays. The use of modified commercial CD drives for high-resolution optical imaging is discussed as well. From a broader perspective, we compare the technical barriers involved in applying microfluidics for sensing and diagnostic as opposed to applying such techniques to HTS. The latter poses less challenges and explains why HTS products based on a CD fluidic platform are already commercially available, while we might have to wait longer to see commercial CD-based diagnostics.

  20. Platforms for Innovation and Internationalization

    Directory of Open Access Journals (Sweden)

    Erik Stavnsager Rasmussen

    2017-05-01

    Full Text Available The high-tech global startup has many challenges related to both innovation and internationalization. From a Danish cluster of Welfare Tech firms, eight innovative and international firms were selected and interviewed. Such firms typically have to be agile and operate in virtual networks in almost all parts of their value chains. This article contributes to the understanding of how innovation and internationalization to a great extent are interlinked. The firms have developed a core product or service offering, which the firms often describe as “a platform”. Around the platform, they develop their products and services for new customers and users in new countries. The firms have to sustain a strong focus on the platform while at the same time developing their platform solution for new products, new customers, and new markets. This pivoting makes it possible to use the platform in a new context but is highly demanding for the firms. They need to be extremely agile and fast-moving but at the same time still to have a focus on the core of the firm: the platform.

  1. Persistent Monitoring Platforms Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Bennett, C L

    2007-02-22

    This project was inspired and motivated by the need to provide better platforms for persistent surveillance. In the years since the inception of this work, the need for persistence of surveillance platforms has become even more widely appreciated, both within the defense community and the intelligence community. One of the most demanding technical requirements for such a platform involves the power plant and energy storage system, and this project concentrated almost exclusively on the technology associated with this system for a solar powered, high altitude, unmanned aircraft. An important realization for the feasibility of such solar powered aircraft, made at the outset of this project, was that thermal energy may be stored with higher specific energy density than for any other known practical form of rechargeable energy storage. This approach has proved to be extraordinarily fruitful, and a large number of spin-off applications of this technology were developed in the course of this project.

  2. Cerveza platforms offer economic options

    Energy Technology Data Exchange (ETDEWEB)

    Leblanc, L.A.

    1982-08-01

    Two single-piece platforms, Cerveze and Cerveza Ligera, were installed by Union Oil Co. in 925-935 ft of water. The technology and equipment used for the two platforms can be used for units to a depth of 1,400 ft in mild climates and to 1,000 ft in more critical weather areas such as the North Sea. The significant improvements in design and procedures in the construction and installation of the Cerveza Ligera platform are: (1) four leg structure, as opposed to eight, requiring less steel; (2) simplified fabrication; and (3) quicker installation. The most significant area of improvement in the Ligera project compared with Cerveza was in communications. Communications between naval architects and onshore launch foremen during loadout, and between surveyors and tug captains during positioning, are cited as examples.

  3. Tax Responses in Platform Industries

    DEFF Research Database (Denmark)

    Kind, Hans Jarle; Köthenbürger, Marko; Schjelderup, Guttorm

    Two-sided platform firms serve distinct customer groups that are connected through interdependent demand, and include major businesses such as the media industry, banking, and the software industry. A well known result of tax incidence is that consumers of a more heavily taxed good pay a higher...... price and thus buy less of the good. The present paper shows that this result need not hold in a two-sided market. On the contrary, a higher ad valorem tax may lower end-user prices and spur sales. Thus, two-sided platform firms may not at all engage in tax shifting via price increases. We further show...

  4. Moodle vs. Social Media Platforms

    DEFF Research Database (Denmark)

    Gulieva, Valeria

    Given the competition coming from various social media platforms, it is explored in this paper how students could be encouraged to use Moodle more proactively during their studies. Moodle is a course management system for online learning. It is designed to be a flexible template-based system, which......, known and widely used social platforms. It might be also due to the fact that students do not see the benefits in investing time and efforts in learning the new system. Another reason might be the mandatory nature of Moodle, i.e., it is imposed on students, rather than a free choice – and this might...

  5. A practice scaffolding interactive platform

    DEFF Research Database (Denmark)

    Bundsgaard, Jeppe

    2009-01-01

    , structures the students' activity, and interactively supports subject learning. A PracSIP facilitates students' development of complex competencies, and at the same time it supports the students' development of skills defined in the curriculum. The paper introduces the concept, presents the theoretical......A Practice Scaffolding Interactive Platform (PracSIP) is a social learning platform which supports students in collaborative project based learning by simulating a professional practice. A PracSIP puts the core tools of the simulated practice at the students' disposal, it organizes collaboration...

  6. 2009 Analysis Platform Review Report

    Energy Technology Data Exchange (ETDEWEB)

    Ferrell, John [Office of Energy Efficiency and Renewable Energy (EERE), Washington, DC (United States

    2009-12-01

    This document summarizes the recommendations and evaluations provided by an independent external panel of experts at the U.S. Department of Energy Biomass Program’s Analysis platform review meeting, held on February 18, 2009, at the Marriott Residence Inn, National Harbor, Maryland.

  7. 2009 Infrastructure Platform Review Report

    Energy Technology Data Exchange (ETDEWEB)

    Ferrell, John [Office of Energy Efficiency and Renewable Energy (EERE), Washington, DC (United States)

    2009-12-01

    This document summarizes the recommendations and evaluations provided by an independent external panel of experts at the U.S. Department of Energy Biomass program‘s Infrastructure platform review meeting, held on February 19, 2009, at the Marriott Residence Inn, National Harbor, Maryland.

  8. Venus Atmospheric Maneuverable Platform (VAMP)

    Science.gov (United States)

    Polidan, R.; Lee, G.; Sokol, D.; Griffin, K.; Bolisay, L.

    2014-05-01

    VAMP is a long lived, semi-buoyant, atmospheric “rover” that deploys in orbit, enters the Venus atmosphere and flies in the Venus atmosphere between 55 and 70 km for up to one year as a platform to address VEXAG goals I.A, I.B, and I.C.

  9. Utilizing platforms in industrialized construction

    DEFF Research Database (Denmark)

    Bonev, Martin; Wörösch, Michael; Hvam, Lars

    2015-01-01

    Purpose – The purpose of this paper is to explore the development of a platform-based projectexecution in the industrialised construction sector, with a focus on systematically balancing cost andvalue. Offering custom-tailored buildings at reasonable costs has been a growing concern for manyconst...

  10. Generational Transitions in Platform Markets

    DEFF Research Database (Denmark)

    Kretschmer, Tobias; Claussen, Jörg

    2016-01-01

    The introduction of a new product generation forces incumbents in platform markets to rebuild their installed base of complementary products. Using three different data sets on the U.S. market for video game consoles, we show that incumbents can, to some extent, substitute for rebuilding their new...

  11. Analysis of offshore jacket platform

    Digital Repository Service at National Institute of Oceanography (India)

    Harish, N.; Mandal, S.; Shanthala, B.; Rao, S.

    -Rohman, M., ‘Multi-loop feedback control of offshore steel jacket platforms’, Computers & Structures 70, 1999, 185–202. 11.Yamamoto, I., Terada, Y., and Yokokura, K., ‘An application of a position keeping control system to floating offshore platform...

  12. Tax Responses in Platform Industries

    DEFF Research Database (Denmark)

    Kind, Hans Jarle; Köthenbürger, Marko; Schjelderup, Guttorm

    Two-sided platform firms serve distinct customer groups that are connected through interdependent demand, and include major businesses such as the media industry, banking, and the software industry. A well known result of tax incidence is that consumers of a more heavily taxed good pay a higher...

  13. 2009 Feedstocks Platform Review Report

    Energy Technology Data Exchange (ETDEWEB)

    Ferrell, John [Office of Energy Efficiency and Renewable Energy (EERE), Washington, DC (United States)

    2009-12-01

    This document summarizes the recommendations and evaluations provided by an independent external panel of experts at the U.S. Department of Energy Biomass Program‘s Feedstock platform review meeting, held on April 8–10, 2009, at the Grand Hyatt Washington, Washington, D.C.

  14. Integrated Alignment and Inspection Platform for High Precision Optical Continuous Images

    Directory of Open Access Journals (Sweden)

    Chuen-Horng Lin

    2014-11-01

    Full Text Available This platform is mainly intended to be used as a facility for high precision optical continuous images. Then, with a fixed pattern being selected, this platform can quickly search, with resistance to variation, the mark that corresponds to the pattern in order to achieve the alignment and inspection target. Since the pattern is a minute component with multiple shapes and unstable features, this platform can automatically acquire it through the system or select it by user. The targets searched by the mark include light, intensity, occlusion and rotation. It then, calculates the variances of light, intensity, occlusion and rotation individually with the mark under detection, search and pattern to achieve the inspection function. Therefore, combined with a quick and accurate mark detection and the search method, this platform builds an interface integrated platform that is easy to operate and user-friendly.

  15. Efficient Approximate Method of Global Reliability Analysis for Offshore Platforms in the Ice Zone

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Ice load is the dominative load in the design of offshore platforms in the ice zone, and the extreme ice load is the key factor that affects the safety of platforms. The present paper studies the statistical properties of the global resistance and the extreme responses of the jacket platforms in Bohai Bay, considering the randomness of ice load, dead load, steel elastic modulus, yield strength and structural member dimensions. Then, based on the above results, an efficient approximate method of the global reliability analysis for the offshore platforms is proposed, which converts the implicit nonlinear performance function in the conventional reliability analysis to linear explicit one. Finally, numerical examples of JZ20-2 MSW, JZ20-2NW and JZ20-2 MUQ offshore jacket platforms in the Bohai Bay demonstrate the satisfying efficiency, accuracy and applicability of the proposed method.

  16. A complete manipulation platform for characterization of micro-components

    Science.gov (United States)

    Canales, C.; Cosandier, F.; Boetsch, G.; Chatagny, V.; Lee, J. H.; Bringout, G.; Clavel, R.

    2008-11-01

    This paper presents a complete manipulation platform for characterization of micro-components that is being developed in the scope of the European project GOLEM. Various tools such as electrical probes and force sensors have been designed and integrated on both high precision mobile micro-robots and fixed manipulators in order to interact with micro-objects. The platform enables the user to characterize parts with sizes ranging from sub-micrometer up to the millimeter. Forces ranging from 1 mN up to 120 mN can be measured as well as electrical resistivity of microcomponents. As the characterization platform is aimed to be used by material scientists and biologists, the manipulation is "assisted" so that the user focuses on the application and not on the robotic systems. One of the key features is that the control software will automatically bring the end-effectors of the manipulators in the local (microscope) field of view. The platform is composed of an XY stage mounted on an inverted optical microscope, of manipulators (fixed and mobile) and of various sensors (optical, force and electrical).

  17. Antibiotic Resistance

    Science.gov (United States)

    ... lives. But there is a growing problem of antibiotic resistance. It happens when bacteria change and become able ... resistant to several common antibiotics. To help prevent antibiotic resistance Don't use antibiotics for viruses like colds ...

  18. Drug Resistance

    Science.gov (United States)

    HIV Treatment Drug Resistance (Last updated 3/2/2017; last reviewed 3/2/2017) Key Points As HIV multiplies in the ... the risk of drug resistance. What is HIV drug resistance? Once a person becomes infected with HIV, ...

  19. Product Platform Development in Industrial Networks

    DEFF Research Database (Denmark)

    Karlsson, Christer; Skold, Martin

    2011-01-01

    The article examines the strategic issues involved in the deployment of product platform development in an industrial network. The move entails identifying the types and characteristics of generically different product platform strategies and clarifying strategic motives and differences. Number...

  20. Parametric modelling of nonstationary platform deck motions

    Digital Repository Service at National Institute of Oceanography (India)

    Mandal, S.

    -sense-stationary processes. Then the time series are modelled by the maximum entropy method which is formulated here for spectral estimation of platform deck displacements. The lower order maximum entropy spectra of nonstationary platform deck displacements are compared...

  1. Front-end conceptual platform modeling

    DEFF Research Database (Denmark)

    Guðlaugsson, Tómas Vignir; Ravn, Poul Martin; Mortensen, Niels Henrik

    2014-01-01

    Platform thinking has been the subject of investigation and deployment in many projects in both academia and industry. Most contributions involve the restructuring of product programs, and only a few support front-end development of a new platform in parallel with technology development....... This contribution deals with the development of product platforms in front-end projects and introduces a modeling tool: the Conceptual Product Platform model. State of the art within platform modeling forms the base of a modeling formalism for a Conceptual Product Platform model. The modeling formalism is explored...... through an example and applied in a case in which the Conceptual Product Platform model has supported the front-end development of a platform for an electro-active polymer technology. The case describes the contents of the model and how its application supported the development work in the project...

  2. The Logic of Digital Platform Disruption

    DEFF Research Database (Denmark)

    Kazan, Erol; Tan, Chee-Wee; Lim, Eric T. K.

    Digital platforms are disruptive IT artifacts, because they facilitate the quick release of innovative platform derivatives from third parties (e.g., apps). This study endeavours to unravel the disruptive potential, caused by distinct designs and configurations of digital platforms on market...... environments. We postulate that the disruptive potential of digital platforms is determined by the degree of alignment among the business, technology and platform profiles. Furthermore, we argue that the design and configuration of the aforementioned three elements dictates the extent to which open innovation...... is permitted. To shed light on the disruptive potential of digital platforms, we opted for payment platforms as our unit of analysis. Through interviews with experts and payment providers, we seek to gain an in-depth appreciation of how contemporary digital payment platforms are designed and configured...

  3. Modeling and analysis of offshore jacket platform

    Digital Repository Service at National Institute of Oceanography (India)

    Mohan, P.; Sidhaarth, K.R.A.; SanilKumar, V.

    This paper details the results obtained from static analysis, considering both operational and ultimate limit state performance characteristics of a jacket platform, designed at Mumbai high basin. The existing platforms at Mumbai high region...

  4. The Logic of Digital Platform Disruption

    DEFF Research Database (Denmark)

    Kazan, Erol; Tan, Chee-Wee; Lim, Eric T. K.

    Digital platforms are disruptive IT artifacts, because they facilitate the quick release of innovative platform derivatives from third parties (e.g., apps). This study endeavours to unravel the disruptive potential, caused by distinct designs and configurations of digital platforms on market...... environments. We postulate that the disruptive potential of digital platforms is determined by the degree of alignment among the business, technology and platform profiles. Furthermore, we argue that the design and configuration of the aforementioned three elements dictates the extent to which open innovation...... is permitted. To shed light on the disruptive potential of digital platforms, we opted for payment platforms as our unit of analysis. Through interviews with experts and payment providers, we seek to gain an in-depth appreciation of how contemporary digital payment platforms are designed and configured...

  5. Product Platform Development in Industrial Networks

    DEFF Research Database (Denmark)

    Karlsson, Christer; Skold, Martin

    2011-01-01

    The article examines the strategic issues involved in the deployment of product platform development in an industrial network. The move entails identifying the types and characteristics of generically different product platform strategies and clarifying strategic motives and differences. Number...

  6. Software development on the SAP HANA platform

    CERN Document Server

    Walker, Mark

    2013-01-01

    Software Development on the SAP HANA Platform is a general tutorial guide to SAP HANA.This book is written for beginners to the SAP HANA platform. No knowledge of SAP HANA is necessary to start using this book.

  7. Hierarchical DSE for multi-ASIP platforms

    DEFF Research Database (Denmark)

    Micconi, Laura; Corvino, Rosilde; Gangadharan, Deepak;

    2013-01-01

    This work proposes a hierarchical Design Space Exploration (DSE) for the design of multi-processor platforms targeted to specific applications with strict timing and area constraints. In particular, it considers platforms integrating multiple Application Specific Instruction Set Processors (ASIPs...

  8. A Platform for Spreadsheet Composition

    CERN Document Server

    Baglietto, Pierpaolo; Mangiante, Simone; Maresca, Massimo; Parodi, Andrea; Stecca, Michele

    2011-01-01

    A huge amount of data is everyday managed in large organizations in many critical business sectors with the support of spreadsheet applications. The process of elaborating spreadsheet data is often performed in a distributed, collaborative way, where many actors enter data belonging to their local business domain to contribute to a global business view. The manual fusion of such data may lead to errors in copy-paste operations, loss of alignment and coherency due to multiple spreadsheet copies in circulation, as well as loss of data due to broken cross-spreadsheet links. In this paper we describe a methodology, based on a Spreadsheet Composition Platform, which greatly reduces these risks. The proposed platform seamlessly integrates the distributed spreadsheet elaboration, supports the commonly known spreadsheet tools for data processing and helps organizations to adopt a more controlled and secure environment for data fusion.

  9. Platform-Independent Courseware Sharing

    Directory of Open Access Journals (Sweden)

    Takao Shimomura

    2013-04-01

    Full Text Available Courseware distribution between different platforms is the major issue of current e-Learning. SCORM (Sharable Content Object Reference Model is one of the solutions for courseware sharing. However, to make SCORM-conformable courseware, some knowledge about HTML and JavaScript is required. This paper presents a SWF (Sharable Web Fragment-based e-Learning system, where courseware is created with sharable Web fragments such as Web pages, images and other resources, and the courseware can be distributed to another platform by export and import facilities. It also demonstrates how to export a subject that contains assignments and problems and how to import the whole subject, only the assignments, or only the problems. The exported meta-information is architecture-independent and provides a model of courseware distribution.

  10. Stabilisation problem in biaxial platform

    Directory of Open Access Journals (Sweden)

    Lindner Tymoteusz

    2016-12-01

    Full Text Available The article describes investigation of rolling ball stabilization problem on a biaxial platform. The aim of the control system proposed here is to stabilize ball moving on a plane in equilibrium point. The authors proposed a control algorithm based on cascade PID and they compared it with another control method. The article shows the results of the accuracy of ball stabilization and influence of applied filter on the signal waveform. The application used to detect the ball position measured by digital camera has been written using a cross platform .Net wrapper to the OpenCV image processing library - EmguCV. The authors used the bipolar stepper motor with dedicated electronic controller. The data between the computer and the designed controller are sent with use of the RS232 standard. The control stand is based on ATmega series microcontroller.

  11. DATABASE REPLICATION IN HETEROGENOUS PLATFORM

    Directory of Open Access Journals (Sweden)

    Hendro Nindito

    2014-01-01

    Full Text Available The application of diverse database technologies in enterprises today is increasingly a common practice. To provide high availability and survavibality of real-time information, a database replication technology that has capability to replicate databases under heterogenous platforms is required. The purpose of this research is to find the technology with such capability. In this research, the data source is stored in MSSQL database server running on Windows. The data will be replicated to MySQL running on Linux as the destination. The method applied in this research is prototyping in which the processes of development and testing can be done interactively and repeatedly. The key result of this research is that the replication technology applied, which is called Oracle GoldenGate, can successfully manage to do its task in replicating data in real-time and heterogeneous platforms.

  12. YARP: Yet Another Robot Platform

    Directory of Open Access Journals (Sweden)

    Lorenzo Natale

    2008-11-01

    Full Text Available We describe YARP, Yet Another Robot Platform, an open-source project that encapsulates lessons from our experience in building humanoid robots. The goal of YARP is to minimize the effort devoted to infrastructure-level software development by facilitating code reuse, modularity and so maximize research-level development and collaboration. Humanoid robotics is a "bleeding edge" field of research, with constant flux in sensors, actuators, and processors. Code reuse and maintenance is therefore a significant challenge. We describe the main problems we faced and the solutions we adopted. In short, the main features of YARP include support for inter-process communication, image processing as well as a class hierarchy to ease code reuse across different hardware platforms. YARP is currently used and tested on Windows, Linux and QNX6 which are common operating systems used in robotics.

  13. Multithreading platform for multimedia applications

    Science.gov (United States)

    Koster, Rainer; Kramp, Thorsten

    2000-12-01

    Complex multimedia applications have diverse resource and timing requirements. A platform for building such programs therefore should supply the developer with mechanisms for managing concurrency, communication, and real-time constraints but should remain flexible with regard to scheduling policies and interaction models. We have developed such a platform consisting of a user-level threads package and operating system extensions. The threads package offers a message-based threading model uniformly integrating synchronous and asynchronous communication, inter-thread synchronization, and signal handling as well as real-time functionality and application-specific scheduling. To support this user-space flexibility an upcall mechanism links the user-level scheduler to the kernel.

  14. Stabilisation problem in biaxial platform

    Science.gov (United States)

    Lindner, Tymoteusz; Rybarczyk, Dominik; Wyrwał, Daniel

    2016-12-01

    The article describes investigation of rolling ball stabilization problem on a biaxial platform. The aim of the control system proposed here is to stabilize ball moving on a plane in equilibrium point. The authors proposed a control algorithm based on cascade PID and they compared it with another control method. The article shows the results of the accuracy of ball stabilization and influence of applied filter on the signal waveform. The application used to detect the ball position measured by digital camera has been written using a cross platform .Net wrapper to the OpenCV image processing library - EmguCV. The authors used the bipolar stepper motor with dedicated electronic controller. The data between the computer and the designed controller are sent with use of the RS232 standard. The control stand is based on ATmega series microcontroller.

  15. Climate News Across Media Platforms

    DEFF Research Database (Denmark)

    Eskjær, Mikkel Fugl

    2015-01-01

    In a changing media landscape marked by technological, institutional and cultural convergence, comparative and cross-media content analysis represents a valuable analytical tool in mapping the diverse channels of climate change communication. This paper presents a comparative study of climate...... change news on five different media platforms: newspapers, television, radio, web-news and mobile news. It investigates the themes and actors represented in public climate change communication as well as the diverse possibilities of participating in public debates and information sharing. By combining...... quantitative and qualitative content analysis the paper documents and explores the extent and character of climate change news across different media platforms. The study aims at contributing to the on-going assessment of how news media are addressing climate change at a time when old and new media...

  16. Reliability-Based Earthquake Design of Jacket-Type Offshore Platforms Considering Pile-Soil-Structure Interaction

    Directory of Open Access Journals (Sweden)

    Behrouz Asgarian

    2009-01-01

    Full Text Available There are plenty of uncertainties in environmental condition of ocean and also in platform element capacities. Reliability-based method could consider these uncertainties. A reliability-based earthquake design method was used to determine the earthquake LRFD parameters for two conventional, steel, pile-supported (template-type offshore platforms located in the Persian Gulf. The pile-soil-structure interaction, the buckling and postbuckling behavior of the braces were considered. Two steel platforms were simulated accurately by the finite element program Opensees. Field data were assumed based on past studies. Sensitiveness of reliability-based method was studied. It was found that the geometry of jacket and different types of braces was important in the capacity and the behavior of offshore platforms. Finally the calculated LRFD elements resistance factors for these two platforms were compared with API recommended factors and it was observed that API recommended element resistance factors were more appropriate for SSL 3.

  17. An Autonomous Platform Simulator (APS)

    Science.gov (United States)

    1989-06-01

    4 Da~c o! Rcp .’rt’ yeur. :nr.e,1 Page Count Master’s Thesi rmT Ju’ne 1 9 9 Ze 16 Supplementary Notat~on 14 The views expressed in this thesis are...the flight volume is based on the firing platform’s current LOS not the LOS at the time of firing. The near and far clipping planes are set to the

  18. Modular Platforms for Optofluidic Systems

    Science.gov (United States)

    Brammer, Marko; Mappes, Timo

    2014-01-01

    Optofluidics is increasingly gaining impact in a number of different fields of research, namely biology and medicine, environmental monitoring and green energy. However, the market for optofluidic products is still in the early development phase. In this manuscript, we discuss modular platforms as a potential concept to facilitate the transfer of optofluidic sensing systems to an industrial implementation. We present microfluidic and optical networks as a basis for the interconnection of optofluidic sensor modules. Finally, we show the potential for entire optofluidic networks

  19. Platform development: implications for portfolio management

    DEFF Research Database (Denmark)

    Hsuan, Juliana; Hansen, Poul H. Kyvsgård

    2007-01-01

    complex, possibly increasing the strategic risks for the firm. This paper reports preliminary findings on platform management process at LEGO, a Danish toy company. Specifically, we report the process of applying games combined with simulations and workshops in the platform development. We also propose...... a framework, based on the portfolio management thinking to evaluate the degree of modularity embedded in a given platform and to which extent it is aligned with other platforms."...

  20. Electrorheological fluid-actuated flexible platform

    Science.gov (United States)

    Liu, Liyu; Niu, Xize; Wen, Weijia; Sheng, Ping

    2006-04-01

    The design, fabrication, and performance of an electrorheological (ER) fluid-actuated flexible platform integrated on a microfluidic chip are reported in this letter. The digitally regulated ER microvalves control the four diaphragms on which a platform is sustained. With electrical input signals, the platform can perform vibrations at tunable frequencies as well as generate complex leveling modes. The flexible platform can potentially act as a microdamper when its inputs are generated from a sensor, in combination with a feedback control system.

  1. System Reliability Assessment of Existing Jacket Platforms in Malaysian Waters

    Directory of Open Access Journals (Sweden)

    V.J. Kurian

    2014-12-01

    Full Text Available Reliability of offshore platforms has become a very important issue in the Malaysian Oil and Gas Industry as, majority of the jacket platforms in Malaysian waters to date, have exceeded their design life. Reliability of a jacket platform can be assessed through reliability index and probability of failure. Conventional metocean consideration uses 100 year return period wave height associated with 100 year return period current velocity and wind speed. However, recent study shows that for Malaysian waters, the proposed metocean consideration should be 100 year return period wave height associated with 10 year return period current velocity and wind speed. Hence, this research investigated the effect of different metocean consideration, to system-based reliability of jacket platforms in Malaysian waters. Prior to that, the effect of different metocean consideration to the pushover analysis has also been studied. Besides, the significance of Pile Soil Interaction (PSI, wave direction and platform geometry were analyzed in a sensitivity study. Pushover analysis was performed on three jacket platforms representing three water regions in Malaysia to obtain Reserve Strength Ratio (RSR as an indicator of the reliability of the jackets. Utilizing sensitivity study parameters mentioned above, seven different case studies were undertaken to study their significance on RSR. The RSR values of each case study were compared and incorporated as resistance model of reliability analysis. Besides, platform specific response model of each jacket has been generated using response surface technique which was later incorporated into the limit state function for reliability analysis. Reliability analysis using First Order Reliability Method (FORM has been conducted in MATLAB to obtain the reliability index and probability of failure. Results from the reliability analysis were compared to analyze the effect of different metocean consideration. In this study, an updated

  2. Towards a Framework of Digital Platform Competition

    DEFF Research Database (Denmark)

    Kazan, Erol; Tan, Chee-Wee; Lim, Eric T. K.

    2016-01-01

    This paper advances a framework for examining the competitive principles of mobile payment platforms. We postulate that the strategic interplay of platform layers will drive the competitive dynamics of platform-driven ubiquitous systems. This framework has been employed in a comparative case study...

  3. A Typology of Multi-sided Platforms

    DEFF Research Database (Denmark)

    Staykova, Kalina Stefanova; Damsgaard, Jan

    2015-01-01

    which evolved several steps into being multi-sided (Facebook). Our analysis shows a structural difference between one-sided, two-sided and multi-sided platforms and that platforms consist of a core and potentially also a periphery. The sides of a platform and the ties which connect them can be arranged...

  4. A Multipurpose CMOS Platform for Nanosensing

    Directory of Open Access Journals (Sweden)

    Alberto Bonanno

    2016-11-01

    Full Text Available This paper presents a customizable sensing system based on functionalized nanowires (NWs assembled onto complementary metal oxide semiconductor (CMOS technology. The Micro-for-Nano (M4N chip integrates on top of the electronics an array of aluminum microelectrodes covered with gold by means of a customized electroless plating process. The NW assembly process is driven by an array of on-chip dielectrophoresis (DEP generators, enabling a custom layout of different nanosensors on the same microelectrode array. The electrical properties of each assembled NW are singularly sensed through an in situ CMOS read-out circuit (ROC that guarantees a low noise and reliable measurement. The M4N chip is directly connected to an external microcontroller for configuration and data processing. The processed data are then redirected to a workstation for real-time data visualization and storage during sensing experiments. As proof of concept, ZnO nanowires have been integrated onto the M4N chip to validate the approach that enables different kind of sensing experiments. The device has been then irradiated by an external UV source with adjustable power to measure the ZnO sensitivity to UV-light exposure. A maximum variation of about 80% of the ZnO-NW resistance has been detected by the M4N system when the assembled 5 μ m × 500 nm single ZnO-NW is exposed to an estimated incident radiant UV-light flux in the range of 1 nW–229 nW. The performed experiments prove the efficiency of the platform conceived for exploiting any kind of material that can change its capacitance and/or resistance due to an external stimulus.

  5. Integrated chemiresistor array for small sensor platforms

    Energy Technology Data Exchange (ETDEWEB)

    HUGHES,ROBERT C.; CASALNUOVO,STEPHEN A.; WESSENDORF,KURT O.; SAVIGNON,DANIEL J.; HIETALA,SUSAN LESLIE; PATEL,SANJAY V.

    2000-04-13

    Chemiresistors are fabricated from materials that change their electrical resistance when exposed to certain chemical species. Composites of soluble polymers with metallic particles have shown remarkable sensitivity to many volatile organic chemicals, depending on the ability of the analyte molecules to swell the polymer matrix. These sensors can be made extremely small (< 100 square microns), operate at ambient temperatures, and require almost no power to read-out. However, the chemiresistor itself is only a part of a more complex sensor system that delivers chemical information to a user who can act on the information. The authors present the design, fabrication and performance of a chemiresistor array chip with four different chemiresistor materials, heaters and a temperature sensor. They also show the design and fabrication of an integrated chemiresistor array, where the electronics to read-out the chemiresistors is on the same chip with the electrodes for the chemiresistors. The circuit was designed to perform several functions to make the sensor data more useful. This low-power, integrated chemiresistor array is small enough to be deployed on a Sandia-developed microrobot platform.

  6. Autonomous biomorphic robots as platforms for sensors

    Energy Technology Data Exchange (ETDEWEB)

    Tilden, M.; Hasslacher, B.; Mainieri, R.; Moses, J.

    1996-10-01

    The idea of building autonomous robots that can carry out complex and nonrepetitive tasks is an old one, so far unrealized in any meaningful hardware. Tilden has shown recently that there are simple, processor-free solutions to building autonomous mobile machines that continuously adapt to unknown and hostile environments, are designed primarily to survive, and are extremely resistant to damage. These devices use smart mechanics and simple (low component count) electronic neuron control structures having the functionality of biological organisms from simple invertebrates to sophisticated members of the insect and crab family. These devices are paradigms for the development of autonomous machines that can carry out directed goals. The machine then becomes a robust survivalist platform that can carry sensors or instruments. These autonomous roving machines, now in an early stage of development (several proof-of-concept prototype walkers have been built), can be developed so that they are inexpensive, robust, and versatile carriers for a variety of instrument packages. Applications are immediate and many, in areas as diverse as prosthetics, medicine, space, construction, nanoscience, defense, remote sensing, environmental cleanup, and biotechnology.

  7. Towards a Framework of Digital Platform Disruption

    DEFF Research Database (Denmark)

    Kazan, Erol; Tan, Chee-Wee; Lim, Eric T. K.

    2014-01-01

    Digital platforms are disruptive information technology (IT) artifacts that erode conventional business logic associated with traditional market structures. This paper presents a framework for examining the disruptive potential of digital platforms whereby we postulate that the strategic interplay...... of governance regimes and platform layers is deterministic of whether disruptive derivatives are permitted to flourish. This framework has been employed in a comparative case study between centralized (i.e., PayPal) and decentralized (i.e., Coinkite) digital payment platforms to illustrate its applicability...... and yield propositions on the nature and impact of digital platform disruptions. Preliminary findings indicate that centralized digital platforms attempt to create unique configurals to obtain monopolistic power by tightly coupling platform layers, which are difficult to replicate. Conversely, decentralized...

  8. Demand forecasting and information platform in tourism

    Science.gov (United States)

    Li, Yue; Jiang, Qi-Jie

    2017-05-01

    Information asymmetry and the bullwhip effect have been serious problems in the tourism supply chain. Based on platform theory, this paper established a mathematical model to explore the inner mechanism of a platform's influence on stakeholders' ability to forecast demand in tourism. Results showed that the variance of stakeholders' demand predictions with a platform was smaller than the variance without a platform, which meant that a platform would improve predictions of demand for stakeholders. The higher information-processing ability of the platform also had other effects on demand forecasting. Research on the inner logic of the platform's influence on stakeholders has important theoretical and realistic value. This area is worthy of further study.

  9. Platform economy in Denmark – precarious employment?

    DEFF Research Database (Denmark)

    Rasmussen, Stine; Madsen, Per Kongshøj

    This paper takes a labour market perspective on the emerging concept of the 'sharing economy' or 'platform economy', which we use as a more appropriate term for the phenomenon. Platform economy is in the article understood as those business models that have emerged since the millennium, where...... digital platforms serve as the link between persons wanting to make use of certain activities, services etc. and those owning them and we only have an interest in the work-related platforms. That means platforms, where paid work is offered and demanded. International examples of this new phenomenon...... of this paper is to examine the work-related activities in the Danish platform economy and discuss whether and to what extent these activities are to be considered precarious forms of employment. The paper begins with a discussion of the terms sharing economy and platform economy in order to reach...

  10. Education Platform at ZDM8.

    Science.gov (United States)

    Lyman Gingerich, Jamie S; Pickart, Michael A; Pierret, Chris

    2016-04-01

    Interest among the zebrafish community in education and science accessibility for all ages has increased. At the 8th Annual Zebrafish Disease Models Conference (ZDM8), a specifically designed session enabled professional scientists, educators, and students to have a venue to present their science, discuss ideas in education, and partner to navigate a scientific meeting as an educational experience. This meeting report describes the format of the Platform Session as well as challenges and future plans to leverage impact of conferences on the local communities.

  11. Generational Transitions in Platform Markets

    DEFF Research Database (Denmark)

    Kretschmer, Tobias; Claussen, Jörg

    2016-01-01

    The introduction of a new product generation forces incumbents in platform markets to rebuild their installed base of complementary products. Using three different data sets on the U.S. market for video game consoles, we show that incumbents can, to some extent, substitute for rebuilding their new...... installed base by making their new products backward compatible, which lets them draw on the installed base of software for the parent generation. However, while this positive direct effect of backward compatibility dominates in our setting, we also observe a (weaker) negative indirect effect working...

  12. Autonomous Landing on Moving Platforms

    KAUST Repository

    Mendoza Chavez, Gilberto

    2016-08-01

    This thesis investigates autonomous landing of a micro air vehicle (MAV) on a nonstationary ground platform. Unmanned aerial vehicles (UAVs) and micro air vehicles (MAVs) are becoming every day more ubiquitous. Nonetheless, many applications still require specialized human pilots or supervisors. Current research is focusing on augmenting the scope of tasks that these vehicles are able to accomplish autonomously. Precise autonomous landing on moving platforms is essential for self-deployment and recovery of MAVs, but it remains a challenging task for both autonomous and piloted vehicles. Model Predictive Control (MPC) is a widely used and effective scheme to control constrained systems. One of its variants, output-feedback tube-based MPC, ensures robust stability for systems with bounded disturbances under system state reconstruction. This thesis proposes a MAV control strategy based on this variant of MPC to perform rapid and precise autonomous landing on moving targets whose nominal (uncommitted) trajectory and velocity are slowly varying. The proposed approach is demonstrated on an experimental setup.

  13. An open-source platform to study uniaxial stress effects on nanoscale devices

    Science.gov (United States)

    Signorello, G.; Schraff, M.; Zellekens, P.; Drechsler, U.; Bürge, M.; Steinauer, H. R.; Heller, R.; Tschudy, M.; Riel, H.

    2017-05-01

    We present an automatic measurement platform that enables the characterization of nanodevices by electrical transport and optical spectroscopy as a function of the uniaxial stress. We provide insights into and detailed descriptions of the mechanical device, the substrate design and fabrication, and the instrument control software, which is provided under open-source license. The capability of the platform is demonstrated by characterizing the piezo-resistance of an InAs nanowire device using a combination of electrical transport and Raman spectroscopy. The advantages of this measurement platform are highlighted by comparison with state-of-the-art piezo-resistance measurements in InAs nanowires. We envision that the systematic application of this methodology will provide new insights into the physics of nanoscale devices and novel materials for electronics, and thus contribute to the assessment of the potential of strain as a technology booster for nanoscale electronics.

  14. A platform for the discovery of new macrolide antibiotics

    Science.gov (United States)

    Seiple, Ian B.; Zhang, Ziyang; Jakubec, Pavol; Langlois-Mercier, Audrey; Wright, Peter M.; Hog, Daniel T.; Yabu, Kazuo; Allu, Senkara Rao; Fukuzaki, Takehiro; Carlsen, Peter N.; Kitamura, Yoshiaki; Zhou, Xiang; Condakes, Matthew L.; Szczypiński, Filip T.; Green, William D.; Myers, Andrew G.

    2016-05-01

    The chemical modification of structurally complex fermentation products, a process known as semisynthesis, has been an important tool in the discovery and manufacture of antibiotics for the treatment of various infectious diseases. However, many of the therapeutics obtained in this way are no longer effective, because bacterial resistance to these compounds has developed. Here we present a practical, fully synthetic route to macrolide antibiotics by the convergent assembly of simple chemical building blocks, enabling the synthesis of diverse structures not accessible by traditional semisynthetic approaches. More than 300 new macrolide antibiotic candidates, as well as the clinical candidate solithromycin, have been synthesized using our convergent approach. Evaluation of these compounds against a panel of pathogenic bacteria revealed that the majority of these structures had antibiotic activity, some efficacious against strains resistant to macrolides in current use. The chemistry we describe here provides a platform for the discovery of new macrolide antibiotics and may also serve as the basis for their manufacture.

  15. Platform development: implications for portfolio management

    DEFF Research Database (Denmark)

    Hsuan, Juliana; Hansen, Poul H. Kyvsgård

    2007-01-01

    " The challenge of implementing industrial platforms in practice can be described as a configuration problem caused by a considerable number of variables, which often have contradictory influences on the total performance of the firm. Consequently, the specific platform decisions become extremely...... a framework, based on the portfolio management thinking to evaluate the degree of modularity embedded in a given platform and to which extent it is aligned with other platforms."...... complex, possibly increasing the strategic risks for the firm. This paper reports preliminary findings on platform management process at LEGO, a Danish toy company. Specifically, we report the process of applying games combined with simulations and workshops in the platform development. We also propose...

  16. Digital platforms as enablers for digital transformation

    DEFF Research Database (Denmark)

    Hossain, Mokter; Lassen, Astrid Heidemann

    2017-01-01

    Digital platforms offer new ways for organizations to collaborate with the external environment for ideas, technologies, and knowledge. They provide new possibilities and competence but they also bring new challenges for organizations. Understanding the role of these platforms in digital...... transformation is crucial. This study aims at exploring how organizations are driven towards transformation in various ways to embrace digital platforms for ideas, technologies, and knowledge. It shows the opportunities and challenges digital platforms bring in organizations. It also highlights underlying...... mechanisms and potential outcomes of various digital platforms. The contribution of the submission is valuable for scholars to understand and further explore this area. It provides insight for practitioners to capture value through digital platforms and accelerate the pace of organizations’ digital...

  17. "Movable platform" - the idea and energy consumption

    OpenAIRE

    Czesław PYPNO; Margielewicz, Jerzy; Gąska, Damian

    2011-01-01

    This paper presents the application of the concept of moving sidewalks at railway stations (the movable platform) including the calculation of electricity consumption. Particular focus was placed on issue of energy profit and loss in two stages - through the loss (consumption) of energy by using a moving sidewalk at a railway station platform and the profit (reduced consumption) of energy, by the lack of having to start the train, that supports movable platform, from the initial speed of 0 km/h.

  18. Applied architecture patterns on the Microsoft platform

    CERN Document Server

    Dovgal, Andre; Noriskin, Gregor

    2014-01-01

    Presented in a scenario-driven tutorial way, we lead you through fictitious example problems and present you with the best solutions. This book is intended for architects, developers, and managers who need to improve their knowledge of the Microsoft application platform. This book will appeal to anyone, especially consultants, who want to get up to speed on selecting the most appropriate platform for a particular problem. A good understanding of the general Windows platform and development technologies would be helpful.

  19. Antimicrobial Resistance

    Science.gov (United States)

    ... emergence and spread of antibacterial resistance, including optimal use of antibiotics in both humans and animals. A global action plan on antimicrobial resistance was adopted by Member States at the ...

  20. A multiplexed microfluidic platform for rapid antibiotic susceptibility testing.

    Science.gov (United States)

    Mohan, Ritika; Mukherjee, Arnab; Sevgen, Selami E; Sanpitakseree, Chotitath; Lee, Jaebum; Schroeder, Charles M; Kenis, Paul J A

    2013-11-15

    Effective treatment of clinical infections is critically dependent on the ability to rapidly screen patient samples to identify antibiograms of infecting pathogens. Existing methods for antibiotic susceptibility testing suffer from several disadvantages, including long turnaround times, excess sample and reagent consumption, poor detection sensitivity, and limited combinatorial capabilities. Unfortunately, these factors preclude the timely administration of appropriate antibiotics, complicating management of infections and exacerbating the development of antibiotic resistance. Here, we seek to address these issues by developing a microfluidic platform that relies on fluorescence detection of bacteria that express green fluorescent protein for highly sensitive and rapid antibiotic susceptibility testing. This platform possesses several advantages compared to conventional methods: (1) analysis of antibiotic action in two to four hours, (2) enhanced detection sensitivity (≈ 1 cell), (3) minimal consumption of cell samples and antibiotic reagents (platform to quantify the effects of four antibiotics (ampicillin, cefalexin, chloramphenicol, tetracycline) and their combinations on Escherichia coli. Within four hours, the susceptibility of bacteria to antibiotics can be determined by detecting variations in maxima of local fluorescence intensity over time. As expected, cell density is a major determinant of antibiotic efficacy. Our results also revealed that combinations of three or more antibiotics are not necessarily better for eradicating pathogens compared to pairs of antibiotics. Overall, this microfluidic based biosensor technology has the potential to provide rapid and precise guidance in clinical therapies by identifying the antibiograms of pathogens. Copyright © 2013 Elsevier B.V. All rights reserved.

  1. Modeling the role of weathering in shore platform development

    Science.gov (United States)

    Trenhaile, Alan S.

    2008-02-01

    A mathematical, wave-erosional model was modified to study the additional effect of weathering by wetting and drying and salt weathering on the development of shore platforms in macro- to mesotidal environments. Model rates of downwearing by these processes, at different tidal elevations, were based on data obtained from a series of laboratory experiments on sandstones from eastern Canada. Backwearing by mechanical wave erosion was calculated using basic wave equations. There were several types of run which were designed to determine the effect of: weathering and the production of fine-grained sediment; the periodic accumulation of debris on weathering in the upper intertidal zone; and weathering in reducing rock resistance and facilitating wave quarrying. The results implied that, compared to mechanical wave erosion, the direct effect of weathering and fine-grained sediment production makes only a small contribution to the long-term development of shore platforms. The relationship between cliff-foot debris occurrence and platform development and morphology was inconsistent because of the negative feedback relationship between erosion rates, surface gradients, and rates of wave attenuation. The model suggested that weathering can play an important, indirect role in assisting wave quarrying of joint blocks and other rock fragments.

  2. Managing Clouds in Cloud Platforms

    CERN Document Server

    Ahmat, Kamal A

    2010-01-01

    Managing cloud services is a fundamental challenge in todays virtualized environments. These challenges equally face both providers and consumers of cloud services. The issue becomes even more challenging in virtualized environments that support mobile clouds. Cloud computing platforms such as Amazon EC2 provide customers with flexible, on demand resources at low cost. However, they fail to provide seamless infrastructure management and monitoring capabilities that many customers may need. For instance, Amazon EC2 doesn't fully support cloud services automated discovery and it requires a private set of authentication credentials. Salesforce.com, on the other hand, do not provide monitoring access to their underlying systems. Moreover, these systems fail to provide infrastructure monitoring of heterogenous and legacy systems that don't support agents. In this work, we explore how to build a cloud management system that combines heterogeneous management of virtual resources with comprehensive management of phys...

  3. Web platform for functional design

    Science.gov (United States)

    Dijmarescu, M. R.; Dijmarescu, M. C.

    2015-11-01

    Today's global competitive trends, especially those related to industries, determine a much higher degree of pressure and demands for substantial innovation driven improvements, flexible and time sensitive solutions. Improving and optimizing the design activity by shortening its timeline and maintaining a high quality level for its output have become the main success factors. The evolution of design activity is strongly related to the evolution of education and research made in the design field. Thus, the development of web tools which can contain knowledge about mechanical products functionality and structure may be an important achievement for the education and industry. This paper presents a web platform which contains functional-constructive knowledge in the area of mechanical design field and was developed to support design activity. The proposed web tool can provide any user, even one without background in design theory, information about the functionality of products and the way it is related to the product structure.

  4. SERS sensors for DVD platform

    DEFF Research Database (Denmark)

    Brøgger, Anna Line

    This Ph.D. thesis explores the engineering of a portable sensor system for detection of rare and small molecules. The Ph.D. project is part of the research project 'Multi-Sensor DVD platform' (MUSE), aiming to integrate different sensors on a rotating disc. The sensors are chosen to complement each...... other, creating more reliable and stable results for the end user. The rotating disc comprises microfluidic channels, which can be utilized for handling and manipulating liquid samples such as blood or water. The focus of this Ph.D. thesis, is on the integration of one specific sensor on a rotating disc....... The sensor is based upon surface enhanced Raman spectroscopy (SERS), which detects molecular vibrations. The aim of this thesis is to cover the different aspects of the sensor system. SERS substrates, consisting of nanopillars with gold or silver caps on top, have been fabricated by standard micro and nano...

  5. Platform for controlled supramolecular nanoassembly.

    Science.gov (United States)

    Czolkos, Ilja; Hannestad, Jonas K; Jesorka, Aldo; Kumar, Ravindra; Brown, Tom; Albinsson, Bo; Orwar, Owe

    2009-06-01

    We here present a two-dimensional (2D) micro/nano-fluidic technique where reactant-doped liquid-crystal films spread and mix on micro- and nanopatterned substrates. Surface-supported phospholipid monolayers are individually doped with complementary DNA molecules which hybridize when these lipid films mix. Using lipid films to convey reactants reduces the dimensionality of traditional 3D chemistry to 2D, and possibly to 1D by confining the lipid film to nanometer-sized lanes. The hybridization event was observed by FRET using single-molecule-sensitive confocal fluorescence detection. We could successfully detect hybridization in lipid streams on 250 nm wide lanes. Our results show that the number and density of reactants as well as sequence of reactant addition can be controlled within confined liquid crystal films, providing a platform for nanochemistry with potential for kinetic control.

  6. Quantum photonics hybrid integration platform

    CERN Document Server

    Murray, Eoin; Meany, Thomas; Flother, Frederick F; Lee, James P; Griffiths, Jonathan P; Jones, Geb A C; Farrer, Ian; Ritchie, David A; Bennet, Anthony J; Shields, Andrew J

    2015-01-01

    Fundamental to integrated photonic quantum computing is an on-chip method for routing and modulating quantum light emission. We demonstrate a hybrid integration platform consisting of arbitrarily designed waveguide circuits and single photon sources. InAs quantum dots (QD) embedded in GaAs are bonded to an SiON waveguide chip such that the QD emission is coupled to the waveguide mode. The waveguides are SiON core embedded in a SiO2 cladding. A tuneable Mach Zehnder modulates the emission between two output ports and can act as a path-encoded qubit preparation device. The single photon nature of the emission was veri?ed by an on-chip Hanbury Brown and Twiss measurement.

  7. Quantum photonics hybrid integration platform

    Energy Technology Data Exchange (ETDEWEB)

    Murray, E.; Floether, F. F. [Cambridge Research Laboratory, Toshiba Research Europe Limited, 208 Science Park, Milton Road, Cambridge CB4 0GZ (United Kingdom); Cavendish Laboratory, University of Cambridge, J.J. Thomson Avenue, Cambridge CB3 0HE (United Kingdom); Ellis, D. J. P.; Meany, T.; Bennett, A. J., E-mail: anthony.bennet@crl.toshiba.co.uk; Shields, A. J. [Cambridge Research Laboratory, Toshiba Research Europe Limited, 208 Science Park, Milton Road, Cambridge CB4 0GZ (United Kingdom); Lee, J. P. [Cambridge Research Laboratory, Toshiba Research Europe Limited, 208 Science Park, Milton Road, Cambridge CB4 0GZ (United Kingdom); Engineering Department, University of Cambridge, 9 J. J. Thomson Avenue, Cambridge CB3 0FA (United Kingdom); Griffiths, J. P.; Jones, G. A. C.; Farrer, I.; Ritchie, D. A. [Cavendish Laboratory, University of Cambridge, J.J. Thomson Avenue, Cambridge CB3 0HE (United Kingdom)

    2015-10-26

    Fundamental to integrated photonic quantum computing is an on-chip method for routing and modulating quantum light emission. We demonstrate a hybrid integration platform consisting of arbitrarily designed waveguide circuits and single-photon sources. InAs quantum dots (QD) embedded in GaAs are bonded to a SiON waveguide chip such that the QD emission is coupled to the waveguide mode. The waveguides are SiON core embedded in a SiO{sub 2} cladding. A tuneable Mach Zehnder interferometer (MZI) modulates the emission between two output ports and can act as a path-encoded qubit preparation device. The single-photon nature of the emission was verified using the on-chip MZI as a beamsplitter in a Hanbury Brown and Twiss measurement.

  8. An Investigation of Digital Payment Platform Designs

    DEFF Research Database (Denmark)

    Kazan, Erol; Damsgaard, Jan

    2014-01-01

    platforms that combines platform, technology and business design aspects. The framework is applied to conduct a comparative case study of digital payment platforms. Four types of market actors are considered: banks, mobile network operators, merchants, and startups, which are incumbents and disrupters....... By hosting third-party services, payment instruments are evolving from single-purpose to multi-functional ones. Our research extends existing payment literature from the MSP perspective to emphasize certain digital payment platform components, which impact strategies and complementary products....

  9. Material platforms for integrated quantum photonics

    CERN Document Server

    Bogdanov, Simeon; Boltasseva, Alexandra; Shalaev, Vladimir M

    2016-01-01

    On-chip integration of quantum optical systems could be a major factor enabling photonic quantum technologies. Unlike the case of electronics, where the essential device is a transistor and the dominant material is silicon, the toolbox of elementary devices required for both classical and quantum photonic integrated circuits is vast. Therefore, many material platforms are being examined to host the future quantum photonic computers and network nodes. We discuss the pros and cons of several platforms for realizing various elementary devices, compare the current degrees of integration achieved in each platform and review several composite platform approaches.

  10. The Innovative Capabilities Of Digital Payment Platforms

    DEFF Research Database (Denmark)

    Kazan, Erol

    2015-01-01

    the support for open innovation. The proposed model has been employed in a comparative case study between two digital payment platforms: Apple Pay and Google Wallet. The findings suggest that digital payment platforms make use of boundary resources to be highly integrative or integratable, which supports...... the intended conjoint commercialization efforts. Furthermore, the architectural design of digital platforms impacts the access to commercialization, resulting to an exclusion or inclusion strategy in accessing value opportunities. Our findings contribute to the open innovation and digital platform literature...

  11. The design of a robotic multichannel platform for photodynamic therapy

    Science.gov (United States)

    Hu, Yida; Finlay, Jarod C.; Zhu, Timothy C.

    2009-06-01

    A compact robotic platform is designed for simultaneous multichannel motion control for light delivery and dosimetry during interstitial photodynamic therapy (PDT). Movements of light sources and isotropic detectors are controlled by individual motors along different catheters for interstitial PDT. The robotic multichannel platform adds feedback control of positioning for up to 16 channels compared to the existing dual-motor system, which did not have positioning encoders. A 16-channel servo motion controller and micro DC motors, each with high resolution optical encoder, are adopted to control the motions of up to 16 channels independently. Each channel has a resolution of 0.1mm and a speed of 5cm/s. The robotic platform can perform light delivery and dosimetry independently, allowing arbitrary positioning of light sources and detectors in each catheter. Up to 16 compact translational channels can be combined according to different operational scheme with real-time optimal motion planning. The characteristic of high speed and coordinating motion will make it possible to use short linear sources (e.g., 1- cm) to deliver uniform PDT treatment to a bulk tumor within reasonable time by source stepping optimization of multiple sources simultaneously. Advanced robotic control algorithm handles the various unexpected circumstance in clinical procedure, e.g., positiontorque/ current control will be applied to prevent excessive force in the case of resistance in the fiber or motorized mechanism. The robotic platform is fully compatible with operation room (OR) environment and improves the light delivery and dosimetry in PDT. It can be adopted for diffusing optical tomography (DOT), spectroscopic DOT and fluorescent spectroscopy.

  12. Offshore Wind Park Connection to an HVDC Platform, without using an AC Collector Platform

    OpenAIRE

    Ahmad, Haseeb

    2012-01-01

    This thesis investigates the comparison between two different alternating current topologies of an offshore wind farms connection to an offshore high voltage direct current (HVDC) converter platform. The offshore high voltage direct current converter platform converts alternating current into direct current. Two different topologies will be investigated. In the first topology, the offshore wind farms are connected to an HVDC converter platform through offshore AC collector platform. An offsho...

  13. Oxide-based platform for reconfigurable superconducting nanoelectronics

    Science.gov (United States)

    Veazey, Joshua P.; Cheng, Guanglei; Irvin, Patrick; Cen, Cheng; Bogorin, Daniela F.; Bi, Feng; Huang, Mengchen; Bark, Chung-Wung; Ryu, Sangwoo; Cho, Kwang-Hwan; Eom, Chang-Beom; Levy, Jeremy

    2013-09-01

    We report quasi-1D superconductivity at the interface of LaAlO3 and SrTiO3. The material system and nanostructure fabrication method supply a new platform for superconducting nanoelectronics. Nanostructures having line widths w ˜ 10 nm are formed from the parent two-dimensional electron liquid using conductive atomic force microscope lithography. Nanowire cross-sections are small compared to the superconducting coherence length in LaAlO3/SrTiO3, placing them in the quasi-1D regime. Broad superconducting transitions versus temperature and finite resistances in the superconducting state well below Tc ≈ 200 mK are observed, suggesting the presence of fluctuation- and heating-induced resistance. The superconducting resistances and V-I characteristics are tunable through the use of a back gate. Four-terminal resistances in the superconducting state show an unusual dependence on the current path, varying by as much as an order of magnitude. This new technology, i.e., the ability to ‘write’ gate-tunable superconducting nanostructures on an insulating LaAlO3/SrTiO3 ‘canvas’, opens possibilities for the development of new families of reconfigurable superconducting nanoelectronics.

  14. 77 FR 20558 - Federal Motor Vehicle Safety Standards; Platform Lifts for Motor Vehicles; Platform Lift...

    Science.gov (United States)

    2012-04-05

    ... National Highway Traffic Safety Administration 49 CFR Part 571 RIN 2127-AJ93 Federal Motor Vehicle Safety Standards; Platform Lifts for Motor Vehicles; Platform Lift Installations in Motor Vehicles AGENCY: National.... SUMMARY: This document adopts amendments to the Federal motor vehicle safety standards on platform...

  15. Efficient High Performance Computing on Heterogeneous Platforms

    NARCIS (Netherlands)

    Shen, J.

    2015-01-01

    Heterogeneous platforms are mixes of different processing units in a compute node (e.g., CPUs+GPUs, CPU+MICs) or a chip package (e.g., APUs). This type of platforms keeps gaining popularity in various computer systems ranging from supercomputers to mobile devices. In this context, improving their

  16. MCloud platform - common government informational infrastructure

    Directory of Open Access Journals (Sweden)

    Eugenia CEBOTARU

    2017-03-01

    Full Text Available MCloud platform is foreseen for the exclusive use by the central administrative authorities and organizational structures within their jurisdiction, subordinated to the Government and is an innovative delivery model based on infrastructure consumption, platform and software as services

  17. Efficient High Performance Computing on Heterogeneous Platforms

    NARCIS (Netherlands)

    Shen, J.

    2015-01-01

    Heterogeneous platforms are mixes of different processing units in a compute node (e.g., CPUs+GPUs, CPU+MICs) or a chip package (e.g., APUs). This type of platforms keeps gaining popularity in various computer systems ranging from supercomputers to mobile devices. In this context, improving their ef

  18. Platform Expansion Design as Strategic Choice

    DEFF Research Database (Denmark)

    Staykova, Kalina S.; Damsgaard, Jan

    2016-01-01

    the main characteristics of the two approaches and to identify the potential trade-offs associated with the selection of particular expansion mode. To this end, we construct the Platform Strategy Framework and apply it to two exemplary cases – WeChat, which functions as a feature bundling platform...

  19. Reflection on Foreign Languages Network Teaching Platform

    Institute of Scientific and Technical Information of China (English)

    LIANG Yuan

    2014-01-01

    This paper aims to build awareness in applying foreign languages network teaching platform to higher education. Teachers rationally use foreign languages network teaching platform to hold an initiative concept, establish a cooperative and in-teractive learning atmosphere, and a prompt and dynamic assessment system.

  20. Maximal workload capacity on moving platforms

    NARCIS (Netherlands)

    Heus, R.; Wertheim, A.H.

    1996-01-01

    Physical tasks on a moving platform required more energy than the same tasks on a non-moving platform. In this study the maximum aerobic performance (defined as V_O2max) of people working on a moving floor was established compared to the maximal aerobic performance on a non-moving floor. The main

  1. Maximal workload capacity on moving platforms

    NARCIS (Netherlands)

    Heus, R.; Wertheim, A.H.

    1996-01-01

    Physical tasks on a moving platform required more energy than the same tasks on a non-moving platform. In this study the maximum aerobic performance (defined as V_O2max) of people working on a moving floor was established compared to the maximal aerobic performance on a non-moving floor. The main qu

  2. PLATFORM SETS FIVE-YEAR GOALS

    Institute of Scientific and Technical Information of China (English)

    1996-01-01

    THE 100,000-word Platform for Action adopted on September 15, 1995, at the UN Fourth World Conference on Women in Beijing, includes six chapters of more than 300 paragraphs. The Platform reviews and evaluates the progress of women since the adoption of the "Nairobi Forward-Looking

  3. A Simulation Platform for Localization and Mapping

    DEFF Research Database (Denmark)

    Sejerøe, Thomas Hanefeld; Poulsen, Niels Kjølstad; Ravn, Ole

    2006-01-01

    In this paper we present a simulation platform for evaluate methods for simultaneous location and mapping. The platform is based on The Kalmtool 3 toolbox which is a set of MATLAB tools for state estimation for nonlinear systems. The toolbox contains functions for extended Kalman filtering as wel...

  4. Selecting a Virtual World Platform for Learning

    Science.gov (United States)

    Robbins, Russell W.; Butler, Brian S.

    2009-01-01

    Like any infrastructure technology, Virtual World (VW) platforms provide affordances that facilitate some activities and hinder others. Although it is theoretically possible for a VW platform to support all types of activities, designers make choices that lead technologies to be more or less suited for different learning objectives. Virtual World…

  5. The Innovative Capabilities Of Digital Payment Platforms

    DEFF Research Database (Denmark)

    Kazan, Erol

    2015-01-01

    the support for open innovation. The proposed model has been employed in a comparative case study between two digital payment platforms: Apple Pay and Google Wallet. The findings suggest that digital payment platforms make use of boundary resources to be highly integrative or integratable, which supports...

  6. Platform Expansion Design as Strategic Choice

    DEFF Research Database (Denmark)

    Staykova, Kalina S.; Damsgaard, Jan

    2016-01-01

    the main characteristics of the two approaches and to identify the potential trade-offs associated with the selection of particular expansion mode. To this end, we construct the Platform Strategy Framework and apply it to two exemplary cases – WeChat, which functions as a feature bundling platform...

  7. Development of a Microelectrode Array Sensing Platform for Combination Electrochemical and Spectrochemical Aqueous Ion Testing.

    Science.gov (United States)

    Gardner, Robert D; Zhou, Anhong; Zufelt, Nephi A

    2009-02-02

    A microelectrode array sensor platform was designed and fabricated to increase diversity, flexibility, and versatility of testing capabilities over that of traditionally reported sensor platforms. These new sensor platforms consist of 18 individual addressable microelectrodes, photolithography fabricated, that employ a glass base substrate and a resist polymer layer that acts as an insulating agent to protect the circuitry and wiring of the sensor from undesired solution interactions. Individually addressable microelectrodes increase diversity by allowing isolated electrochemical testing between electrodes, global array testing, or some combination of electrodes to perform electrochemical methods. Furthermore, because of the optical transparency of the glass base substrate and the resist mask layer, along with the small size of the electrode array, spectrochemical analysis is possible within the sample area that acts as electrochemical cell and cuvette, while the microelectrode array passively resides within the optical path length during spectrochemical testing. This unique arrangement offers improved testing possibilities for various applications, including simultaneous electrochemical and spectrochemical analysis in environmental testing, identification or quantification of possible species for bioavailability in the biotechnology field, and process control in industrial applications. Electrochemical characteristics and spectrochemcial use of the sensor platform are proven with potassium ferricyanide, an electrochemical standard analyte, and electrochemical measurements are compared against a commercially available working electrode of similar size. Additionally, the electrochemical method of differential pulse anodic stripping voltammetry is performed with the sensor platform to detect copper and lead heavy metal ions in aqueous solution, demonstrating the potential for use with environmental samples.

  8. Venus Atmospheric Maneuverable Platform (VAMP)

    Science.gov (United States)

    Polidan, R.; Lee, G.; Sokol, D.; Griffin, K.; Bolisay, L.; Barnes, N.

    2014-04-01

    Over the past years we have explored a possible new approach to Venus upper atmosphere exploration by applying recent Northrop Grumman (non-NASA) development programs to the challenges associated with Venus upper atmosphere science missions. Our concept is a low ballistic coefficient (aircraft that deploys prior to entering the Venus atmosphere, enters the Venus atmosphere without an aeroshell, and provides a long-lived (months to years), maneuverable vehicle capable of carrying science payloads to explore the Venus upper atmosphere. VAMP targets the global Venus atmosphere between 55 and 70 km altitude and would be a platform to address VEXAG goals I.A, I.B, and I.C. We will discuss the overall mission architecture and concept of operations from launch through Venus arrival, orbit, entry, and atmospheric science operations. We will present a strawman concept of VAMP, including ballistic coefficient, planform area, percent buoyancy, inflation gas, wing span, vehicle mass, power supply, propulsion, materials considerations, structural elements, subsystems, and packaging. The interaction between the VAMP vehicle and the supporting orbiter will also be discussed. In this context, we will specifically focus upon four key factors impacting the design and performance of VAMP: 1. Science payload accommodation, constraints, and opportunities 2. Characteristics of flight operations and performance in the Venus atmosphere: altitude range, latitude and longitude access, day/night performance, aircraft performance, performance sensitivity to payload weight 3. Feasibility of and options for the deployment of the vehicle in space 4. Entry into the Venus atmosphere, including descent profile, heat rate, total heat load, stagnation temperature, control, and entry into level flight We will discuss interdependencies of the above factors and the manner in which the VAMP strawman's characteristics affect the CONOPs and the science objectives. We will show how the these factors provide

  9. Reinventing the Platform Core Through Acquisition

    DEFF Research Database (Denmark)

    Toppenberg, Gustav; Henningsson, Stefan; Eaton, Ben

    2016-01-01

    Digital platform leaders need to continuously innovate the platform core to drive the technological trajectory of the overall architecture and business system, of which the platform is a core element. This papers analyses the potential of and challenges to completing this task through...... the acquisition and integration of companies presenting innovative technologies of relevance to the platform core. Using a revelatory case study of Cisco Systems, we develop the explanatory notion of ‘coring acquisition’. In this type of acquisition value is created through the acquisition of companies...... that provide products external to the acquirer that can be assimilated into the platform core. This creates value through the transformational process that we term ‘coring’. We also analyze how the benefits of coring acquisitions are contingent on challenges concerning the integration of acquisitions offering...

  10. Peer-to-Peer Service Sharing Platforms

    DEFF Research Database (Denmark)

    Andersson, Magnus; Hjalmarsson, Anders; Avital, Michel

    2013-01-01

    The sharing economy has been growing continuously in the last decade thanks to the proliferation of internet-based platforms that allow people to disintermediate the traditional commercial channels and to share excess resources and trade with one another effectively at a reasonably low transaction...... cost. Whereas early peer-to-peer platforms were designed to enable file sharing and goods trading, we recently witness the emergence of a new breed of peer-to-peer platforms that are designed for ordinary service sharing. Ordinary services entail intangible provisions and are defined as an economic...... activity that generates immaterial benefits and does not result in ownership of material goods. Based on a structured analysis of 41 internet-based rideshare platforms, we explore and layout the unique characteristics of peer-to-peer service sharing platforms based on three distinct temporal patterns...

  11. ENERCA: e-learning platform

    Directory of Open Access Journals (Sweden)

    Patricia Aguilar-Martínez

    2014-12-01

    Full Text Available ENERCA (the European Network for Rare and Congenital Anemias is a European Commission funded project since 2002. Rare anaemias in Europe comprise haemoglobin disorders, such as thalassemias or sickle cell disease, and other rarer disorders, including inherited diseases of the red cell membrane, of the red cell enzymes, as well as anaemias related to disorders of iron metabolism. Education and training on rare anaemias is one of the main objectives of ENERCA and several educational initiatives have been undertaken during the past and present phases of the project. Among these, the organisation of courses for health professionals, the provision of videos with prevention messages for patients and general practitioners were part of the previous phase, ENERCA 3. In the current phase of the ENERCA project, called e-ENERCA, the workpackage dedicated to Education and Training mainly focuses on training of young physicians, biologists or scientists in the field of diagnosis and management of rare anaemias. The specificity of e-ENERCA is to be based principally on new communication e-tool. Two main educational axes will be developed: the organisation of on-site courses including interactive sessions with voting boxes and the implementation of an online e-learning platform.

  12. Basin Assessment Spatial Planning Platform

    Energy Technology Data Exchange (ETDEWEB)

    2017-07-26

    The tool is intended to facilitate hydropower development and water resource planning by improving synthesis and interpretation of disparate spatial datasets that are considered in development actions (e.g., hydrological characteristics, environmentally and culturally sensitive areas, existing or proposed water power resources, climate-informed forecasts). The tool enables this capability by providing a unique framework for assimilating, relating, summarizing, and visualizing disparate spatial data through the use of spatial aggregation techniques, relational geodatabase platforms, and an interactive web-based Geographic Information Systems (GIS). Data are aggregated and related based on shared intersections with a common spatial unit; in this case, industry-standard hydrologic drainage areas for the U.S. (National Hydrography Dataset) are used as the spatial unit to associate planning data. This process is performed using all available scalar delineations of drainage areas (i.e., region, sub-region, basin, sub-basin, watershed, sub-watershed, catchment) to create spatially hierarchical relationships among planning data and drainages. These entity-relationships are stored in a relational geodatabase that provides back-end structure to the web GIS and its widgets. The full technology stack was built using all open-source software in modern programming languages. Interactive widgets that function within the viewport are also compatible with all modern browsers.

  13. The ideal hydrogen demonstration platform

    Energy Technology Data Exchange (ETDEWEB)

    Alt, J. [Village Technology, Annapolis, MD (United States)

    2007-07-01

    This paper suggested that the best platform to demonstrate hydrogen's capability as an emission-free fuel regime is an urban pedestrian system. The on-grade bi-directional downtown people-mover was designed to fit in existing street-scapes without eliminating traffic lanes. The system is comprised of rubber-tired tram-buses that are synchronized to arrive at stop-boarding areas at the same time in order to provide a seamless headway along a single, dedicated guide-lane. The system was designed to operate along strategic urban corridors in order to reduce traffic congestion and air pollution. The vehicles are inductively charged with fixed fuel cell generators at stop-boarding areas. A single people-mover has the capacity to replace several thousand car trips and parking movements per day, or 8000 tonnes of carbon dioxide (CO{sub 2}). It was concluded that the system was designed to dovetail with fuel cell generator stations planned for private vehicles as they begin to be converted in the future. 8 figs.

  14. Comparison of Hybrid Cross-Platform Mobile Applications with Native Cross-Platform Applications

    Directory of Open Access Journals (Sweden)

    NOVAC Ovidiu Constantin

    2016-10-01

    Full Text Available In this paper we present two types of cross platform mobile applications, we will look at the advantages and disadvantages of each one. Hybrid applications are HTML5/Javascript applications which are given a native device wrapper in order to be able to run as a stand-alone application, rather than a web page which has to be rendered in the web browser. These types of application look the same on each platform they are deployed to. Native cross platform applications offers platform-like styling, making almost impossible to tell the difference between a native and a cross platform application.

  15. Camptothecin resistance

    DEFF Research Database (Denmark)

    Brangi, M; Litman, Thomas; Ciotti, M;

    1999-01-01

    The mitoxantrone resistance (MXR) gene encodes a recently characterized ATP-binding cassette half-transporter that confers multidrug resistance. We studied resistance to the camptothecins in two sublines expressing high levels of MXR: S1-M1-80 cells derived from parental S1 colon cancer cells...... and MCF-7 AdVp3,000 isolated from parental MCF-7 breast cancer cells. Both cell lines were 400- to 1,000-fold more resistant to topotecan, 9-amino-20(S)-camptothecin, and the active metabolite of irinotecan, 7-ethyl-10-hydroxycamptothecin (SN-38), than their parental cell lines. The cell lines...... demonstrated much less resistance to camptothecin and to several camptothecin analogues. Reduced accumulation and energy-dependent efflux of topotecan was demonstrated by confocal microscopy. A significant reduction in cleavable complexes in the resistant cells could be observed after SN-38 treatment...

  16. Plastic and Elastic Responses of a Jacket Platform Subjected to Ship Impacts

    Directory of Open Access Journals (Sweden)

    Liang Li

    2013-01-01

    Full Text Available This paper deals with ship-jacket platform collisions. An examination on NORSOK N-004 rule is carried out. Furthermore, elastic and plastic response of jacket platform is studied. This paper also conducts a sensitivity analysis, focusing on collision points. Simulation models of a ductile and a rigid supply vessel were developed, as well as models of two typical jacket platforms. Data such as collision force, kinetic energy, and deformation energy have been obtained. Several conclusions have been drawn: NORSOK rule underestimates the resistance for certain indention, due to inaccurate description of column deformation mode. Elastic response is extremely important in dynamic analysis of ship-platform impacts, by contributing to reducing impact loads and local energy dissipation. Struck members are therefore subjected to impacts to a low extent, which can be regarded as result of a buffering effect. Before a buffering effect works, a time delay exists. This is caused because the topside has to take up adequate kinetic energy. Striking position has an effect on dynamic behavior of platform. High local strength is in favor of buffering an effect. Elastic response is more significant in a flexible platform than in a sticky one.

  17. Miniaturized platform with on-chip strain sensors for compression testing of arrayed materials.

    Science.gov (United States)

    MacQueen, Luke; Chebotarev, Oleg; Simmons, Craig A; Sun, Yu

    2012-10-21

    We report a microfabricated mechanical testing platform with on-chip strain sensors for in situ mechanical characterization of arrayed materials. The device is based on deformable elastomeric membranes that are actuated by pressure that is delivered through an underlying channel network. The bulging membranes compress material samples that are confined between the membranes and a rigid top-plate. Carbon nanotube-based strain sensors that exhibit strain-dependent electrical resistivity were integrated within the membranes to provide continuous read-out of membrane deflection amplitude. We used this platform to study the cyclic compression of several different silicone samples and thereby measured their elastic moduli. The results obtained using our miniaturized platform were in excellent agreement with those obtained using a commercially available mechanical testing platform and clearly demonstrated the utility of our platform for the mechanical testing of small samples in parallel. The miniaturized platform can significantly increase mechanical testing efficiency, particularly when testing of iterative sample formulations is required.

  18. Sociomaterial Practices: Challenges in Developing a Virtual Business Community Platform in Agriculture

    Directory of Open Access Journals (Sweden)

    Norberto Hoppen

    2017-07-01

    Full Text Available Virtual business communities (VBC are virtual networks of people who share common interests and comprise online software platforms that enables the fast exchange of information, collaboration and business interactions. From 2011 to 2015, we developed a design science research to create a VBC platform for an agricultural cluster of flower growers in the South of Brazil. The goal of this platform was to help to structure and strengthen this cluster by bringing together buyers and sellers while fostering cooperation to boost cluster competitiveness and economic development in the region. However, a number of challenges surfaced during the process, which led to a failure in the VBC platform’s diffusion. We adopted a sociomaterial perspective based on the mangle of practice concept (Pickering, 1993 to investigate this failure, by analyzing the key challenges involved in developing a VBC platform in an agricultural context. As its main result, this paper reveals the mangling process during the design and application of the VBC platform and details the different instances of tuning between the participants and the technology. We observed resistance and factors that weakened cooperation and resulted in a lack of governance rules, which are key to the success of a VBC platform.

  19. Reliability of plantar pressure platforms.

    Science.gov (United States)

    Hafer, Jocelyn F; Lenhoff, Mark W; Song, Jinsup; Jordan, Joanne M; Hannan, Marian T; Hillstrom, Howard J

    2013-07-01

    Plantar pressure measurement is common practice in many research and clinical protocols. While the accuracy of some plantar pressure measuring devices and methods for ensuring consistency in data collection on plantar pressure measuring devices have been reported, the reliability of different devices when testing the same individuals is not known. This study calculated intra-mat, intra-manufacturer, and inter-manufacturer reliability of plantar pressure parameters as well as the number of plantar pressure trials needed to reach a stable estimate of the mean for an individual. Twenty-two healthy adults completed ten walking trials across each of two Novel emed-x(®) and two Tekscan MatScan(®) plantar pressure measuring devices in a single visit. Intraclass correlation (ICC) was used to describe the agreement between values measured by different devices. All intra-platform reliability correlations were greater than 0.70. All inter-emed-x(®) reliability correlations were greater than 0.70. Inter-MatScan(®) reliability correlations were greater than 0.70 in 31 and 52 of 56 parameters when looking at a 10-trial average and a 5-trial average, respectively. Inter-manufacturer reliability including all four devices was greater than 0.70 for 52 and 56 of 56 parameters when looking at a 10-trial average and a 5-trial average, respectively. All parameters reached a value within 90% of an unbiased estimate of the mean within five trials. Overall, reliability results are encouraging for investigators and clinicians who may have plantar pressure data sets that include data collected on different devices.

  20. A Multichannel Bioluminescence Determination Platform for Bioassays.

    Science.gov (United States)

    Kim, Sung-Bae; Naganawa, Ryuichi

    2016-01-01

    The present protocol introduces a multichannel bioluminescence determination platform allowing a high sample throughput determination of weak bioluminescence with reduced standard deviations. The platform is designed to carry a multichannel conveyer, an optical filter, and a mirror cap. The platform enables us to near-simultaneously determine ligands in multiple samples without the replacement of the sample tubes. Furthermore, the optical filters beneath the multichannel conveyer are designed to easily discriminate colors during assays. This optical system provides excellent time- and labor-efficiency to users during bioassays.

  1. CORBA Based Information Integration Platform for CIMS

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    A new information integration platform for computer integrated manufacturing system(CIMS) is presented, which is based on agent and CORBA. CORBA enhances the system integration be-cause it is an industry-standard for interoperable, distributed objects across heterogeneous hardware andsoftware platform. Agent technology is used to improve intelligence of integration system. In order to im-plement the information integration platform, we use network integration server to integrate network, de-sign a generic database agent to integrate database, adopt multi-agent based architecture to integrate appli-cation, and utilize wrapper as CORBA object to integrate legacy code.

  2. Design for game based learning platforms

    DEFF Research Database (Denmark)

    Sørensen, Birgitte Holm; Meyer, Bente

    2010-01-01

    Council for Strategic Research, in which an online game-based platform for English as a foreign language in primary school is studied. The paper presents a model for designing for game based learning platforms. This design is based on cultural and ethnographic based research on children's leisure time use......This paper focuses on the challenges related to the design of game based learning platforms for formal learning contexts that are inspired by the pupil's leisure time related use of web 2.0. The paper is based on the project Serious Games on a Global Market Place (2007-2011) founded by the Danish...

  3. Secure smart embedded devices, platforms and applications

    CERN Document Server

    Markantonakis, Konstantinos

    2013-01-01

    New generations of IT users are increasingly abstracted from the underlying devices and platforms that provide and safeguard their services. As a result they may have little awareness that they are critically dependent on the embedded security devices that are becoming pervasive in daily modern life. Secure Smart Embedded Devices, Platforms and Applications provides a broad overview of the many security and practical issues of embedded devices, tokens, and their operation systems, platforms and main applications. It also addresses a diverse range of industry/government initiatives and consider

  4. Genesis and Evolution of Digital Payment Platforms

    DEFF Research Database (Denmark)

    Hjelholt, Morten; Damsgaard, Jan

    2012-01-01

    Payment transactions through the use of physical coins, bank notes or credit cards have for centuries been the standard formats of exchanging money. Recently online and mobile digital payment platforms has entered the stage as contenders to this position and possibly could penetrate societies...... applies a co-evolutionary multilevel perspective to model the interplay and processes between technology and society wherein digital payment platforms potentially will substitute other payment platforms just like the credit card negated the check. On this basis this paper formulate a multilevel conceptual...

  5. THE NEED FOR FUNCTION PLATFORMS IN ENGINEER TO ORDER INDUSTRIES

    NARCIS (Netherlands)

    Alblas, Alex; Wortmann, Hans; Bergendahl, MN; Grimheden, M; Leifer, L; Skogstad, P; Cantamessa, M

    2009-01-01

    Many industries base their innovations on product platforms. Platforms have predefined modularity with standardized interfaces. However, product platforms provide significant challenges to engineering industries that rely heavily on R&D, such as microlithography systems. Developing these systems dep

  6. THE NEED FOR FUNCTION PLATFORMS IN ENGINEER TO ORDER INDUSTRIES

    NARCIS (Netherlands)

    Alblas, Alex; Wortmann, Hans; Bergendahl, MN; Grimheden, M; Leifer, L; Skogstad, P; Cantamessa, M

    2009-01-01

    Many industries base their innovations on product platforms. Platforms have predefined modularity with standardized interfaces. However, product platforms provide significant challenges to engineering industries that rely heavily on R&D, such as microlithography systems. Developing these systems dep

  7. THE NEED FOR FUNCTION PLATFORMS IN ENGINEER TO ORDER INDUSTRIES

    NARCIS (Netherlands)

    Alblas, Alex; Wortmann, Hans; Bergendahl, MN; Grimheden, M; Leifer, L; Skogstad, P; Cantamessa, M

    2009-01-01

    Many industries base their innovations on product platforms. Platforms have predefined modularity with standardized interfaces. However, product platforms provide significant challenges to engineering industries that rely heavily on R&D, such as microlithography systems. Developing these systems

  8. Antibiotic Resistance

    DEFF Research Database (Denmark)

    Munck, Christian

    morbidity and mortality as well as an increase in the cost of treatment. Understanding how bacteria respond to antibiotic exposure gives the foundations for a rational approach to counteract antimicrobial resistance. In the work presented in this thesis, I explore the two fundamental sources...... of antimicrobial resistance: (1) adaptive mutations and (2) horizontal acquisition of resistance genes from antibiotic gene reservoirs. By studying the geno- and phenotypic changes of E. coli in response to single and drug-pair exposures, I uncover the evolutionary trajectories leading to adaptive resistance. I...... to rationally design drug combinations that limit the evolution of antibiotic resistance due to counteracting evolutionary trajectories. My results highlight that an in-depth knowledge about the genetic responses to the individual antimicrobial compounds enables the prediction of responses to drug combinations...

  9. Summary of Fe opacity measurement platform

    Energy Technology Data Exchange (ETDEWEB)

    Nagayama, Taisuke

    2016-05-01

    This powerpoint presentation goes over the Fe opacity measurement platform, including how the experiment works, what can be gathered from the measurements, what can be gathered from the simulations, and the limitations of the experiment.

  10. 2011 Biomass Program Platform Peer Review: Feedstock

    Energy Technology Data Exchange (ETDEWEB)

    McCann, Laura [Office of Energy Efficiency and Renewable Energy (EERE), Washington, DC (United States)

    2012-02-01

    This document summarizes the recommendations and evaluations provided by an independent external panel of experts at the 2011 U.S. Department of Energy Biomass Program’s Feedstock Platform Review meeting.

  11. 2011 Biomass Program Platform Peer Review. Infrastructure

    Energy Technology Data Exchange (ETDEWEB)

    Lindauer, Alicia [Office of Energy Efficiency and Renewable Energy (EERE), Washington, DC (United States)

    2012-02-01

    This document summarizes the recommendations and evaluations provided by an independent external panel of experts at the 2011 U.S. Department of Energy Biomass Program’s Infrastructure Platform Review meeting.

  12. 2011 Biomass Program Platform Peer Review: Algae

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Joyce [Office of Energy Efficiency and Renewable Energy (EERE), Washington, DC (United States)

    2012-02-01

    This document summarizes the recommendations and evaluations provided by an independent external panel of experts at the 2011 U.S. Department of Energy Biomass Program’s Algae Platform Review meeting.

  13. Model refinement for offshore platforms: Experimental study

    Science.gov (United States)

    Zhang, Min; Chen, Zongli; Wu, Yanjian

    2017-08-01

    Offshore jacket platforms are widely used in offshore oil and gas exploitation. Finite element models of such structures need to have many degrees of freedom (DOFs) to represent the geometrical detail of complex structures, thereby leading to incompatibility in the number of DOFs of experimental models. To bring them both to the same order while ensuring that the essential eigen- properties of the refined model match those of experimental models, an extended model refinement procedure is presented in this paper. Vibration testing of an offshore jacket platform model is performed to validate the applicability of the proposed approach. A full-order finite element model of the platform is established and then tuned to meet the measured modal properties identified from the acceleration signals. Both model reduction and modal expansion methods are investigated, as well as various scenarios of sensor arrangements. Upon completion of the refinement, the updated jacket platform model matches the natural frequencies of the measured model well.

  14. Introducing Blackboard: an electronic learning platform.

    Science.gov (United States)

    Cader, Raffik; McGovern, Michael

    Blackboard, an internet-based platform for teaching and learning, was introduced to students on the preregistration nursing programme at Northumbria University. Although clear educational advantages were identified, there were also potential pitfalls.

  15. Designing platform independent mobile apps and services

    CERN Document Server

    Heckman, Rocky

    2016-01-01

    This book explains how to help create an innovative and future proof architecture for mobile apps by introducing practical approaches to increase the value and flexibility of their service layers and reduce their delivery time. Designing Platform Independent Mobile Apps and Services begins by describing the mobile computing landscape and previous attempts at cross platform development. Platform independent mobile technologies and development strategies are described in chapter two and three. Communication protocols, details of a recommended five layer architecture, service layers, and the data abstraction layer are also introduced in these chapters. Cross platform languages and multi-client development tools for the User Interface (UI) layer, as well as message processing patterns and message routing of the Service Int rface (SI) layer are explained in chapter four and five. Ways to design the service layer for mobile computing, using Command Query Responsibility Segregation (CQRS) and the Data Abstraction La...

  16. STUDY OF VARIOUS INTERNET OF THINGS PLATFORMS

    Directory of Open Access Journals (Sweden)

    Bhumi Nakhuva

    2015-12-01

    Full Text Available Internet of Things is a technological revolution which provides the vision of connected world of Things. Devices, people and systems are connected with one another in such a way that they can communicate with each other over Internet. So the form of communication from human-human is now turned into humanhuman, human-things and things- things. Variety of platforms are now a days available that can support entire development to deployment of IoT applications and systems. In this paper, we will first start with the introduction of IoT platforms as well as IoT middleware and then will discuss various IoT platforms, compare various IoT platforms and will end up with the conclusion.

  17. Embedded Based Miniaturized Universal Electrochemical Sensing Platform

    Directory of Open Access Journals (Sweden)

    Jiamin Chen

    2016-01-01

    Full Text Available We created an embedded sensing platform based on STM32 embedded system, with integrated carbon-electrode ionic sensor by using a self-made plug. Given ration of concentration-unknown nitrate liquid samples, this platform is able to measure the nitrate concentration in neutral environment. Response signals which were transmitted by the sensor can be displayed via a serial port to the computer screen or via Bluetooth to the smartphone. Processed by a fitting function, signals are transformed into related concentration. Through repeating the experiment many times, the accuracy and repeatability turned out to be excellent. The results can be automatically stored on smartphone via Bluetooth. We created this embedded sensing platform for field water quality measurement. This platform also can be applied for other micro sensors’ signal acquisition and data processing.

  18. Computing platforms for software-defined radio

    CERN Document Server

    Nurmi, Jari; Isoaho, Jouni; Garzia, Fabio

    2017-01-01

    This book addresses Software-Defined Radio (SDR) baseband processing from the computer architecture point of view, providing a detailed exploration of different computing platforms by classifying different approaches, highlighting the common features related to SDR requirements and by showing pros and cons of the proposed solutions. Coverage includes architectures exploiting parallelism by extending single-processor environment (such as VLIW, SIMD, TTA approaches), multi-core platforms distributing the computation to either a homogeneous array or a set of specialized heterogeneous processors, and architectures exploiting fine-grained, coarse-grained, or hybrid reconfigurability. Describes a computer engineering approach to SDR baseband processing hardware; Discusses implementation of numerous compute-intensive signal processing algorithms on single and multicore platforms; Enables deep understanding of optimization techniques related to power and energy consumption of multicore platforms using several basic a...

  19. 2011 Biomass Program Platform Peer Review. Sustainability

    Energy Technology Data Exchange (ETDEWEB)

    Eng, Alison Goss [Office of Energy Efficiency and Renewable Energy (EERE), Washington, DC (United States)

    2012-02-01

    This document summarizes the recommendations and evaluations provided by an independent external panel of experts at the 2011 U.S. Department of Energy Biomass Program’s Sustainability Platform Review meeting.

  20. 2011 Biomass Program Platform Peer Review: Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Haq, Zia [Office of Energy Efficiency and Renewable Energy (EERE), Washington, DC (United States)

    2012-02-01

    This document summarizes the recommendations and evaluations provided by an independent external panel of experts at the 2011 U.S. Department of Energy Biomass Program’s Analysis Platform Review meeting.

  1. Developing a social media platform for nurses.

    Science.gov (United States)

    Jackson, Jennifer; Kennedy, Maggie

    2015-11-18

    Social media tools provide opportunities for nurses to connect with colleagues and patients and to advance personally and professionally. This article describes the process of developing an innovative social media platform at a large, multi-centre teaching hospital, The Ottawa Hospital, Canada, and its benefits for nurses. The platform, TOH Nurses, was developed using a nursing process approach, involving assessment, planning, implementation and evaluation. The aim of this initiative was to address the barriers to communication inherent in the large number of nurses employed by the organisation, the physical size of the multi-centre hospital and the shift-work nature of nursing. The platform was used to provide educational materials for clinical nurses, and to share information about professional practice. The implications of using a social media platform in a healthcare setting were considered carefully during its development and implementation, including concerns regarding privacy and confidentiality.

  2. Energy-aware scheduling on multiprocessor platforms

    CERN Document Server

    Li, Dawei

    2014-01-01

    Multiprocessor platforms play important roles in modern computing systems, and appear in various applications, ranging from energy-limited hand-held devices to large data centers. As the performance requirements increase, energy-consumption in these systems also increases signi cantly. Dynamic Voltage and Frequency Scaling (DVFS), which allows processors to dynamically adjust the supply voltage and the clock frequency to operate on di erent power/energy levels, is considered an e ective way to achieve the goal of energy-saving. This book surveys existing works that have been on energy-aware task scheduling on DVFS multiprocessor platforms. Energy-aware scheduling problems are intrinsically optimization problems, the formulations of which greatly depend on the platform and task models under consideration. Thus, Energy-aware Scheduling on Multiprocessor Platforms covers current research on this topic and classi es existing works according to two key standards, namely, homogeneity/heterogeneity of multi processo...

  3. Cloud Based Applications and Platforms (Presentation)

    Energy Technology Data Exchange (ETDEWEB)

    Brodt-Giles, D.

    2014-05-15

    Presentation to the Cloud Computing East 2014 Conference, where we are highlighting our cloud computing strategy, describing the platforms on the cloud (including Smartgrid.gov), and defining our process for implementing cloud based applications.

  4. Composite nanowire networks for biological sensor platforms

    Science.gov (United States)

    Jabal, Jamie Marie Francisco

    The main goal of this research is to design, fabricate, and test a nanomaterial-based platform adequate for the measurement of physiological changes in living cells. The two primary objectives toward this end are (1) the synthesis and selection of a suitable nanomaterial and (2) the demonstration of cellular response to a direct stimulus. Determining a useful nanomaterial morphology and behavior within a sensor configuration presented challenges based on cellular integration and access to electrochemical characterization. The prospect for feasible optimization and eventual scale-up in technology were also significant. Constraining criteria are that the nanomaterial detector must (a) be cheap and relatively easy to fabricate controllably, (b) encourage cell attachment, (c) exhibit consistent wettability over time, and (d) facilitate electrochemical processes. The ultimate goal would be to transfer a proof-of-principle and proof-of-design for a whole-cell sensor technology that is cost effective and has a potential for hand-held packaging. Initial tasks were to determine an effective and highly-functional nanomaterial for biosensors by assessing wettability, morphology and conductivity behavior of several candidate materials: gallium nitride nanowires, silicon dioxide nanosprings and nanowires, and titania nanofibers. Electrospinning poly(vinyl pyrrolidone)-coated titania nano- and microfibers (O20 nm--2 microm) into a pseudo-random network is controllable to a uniformity of 1--2° in contact angle. The final electrode can be prepared with a precise wettability ranging from partial wetting to ultrahydrophobic (170°) on a variety of substrates: glass, indium tin oxide, silicon, and aluminum. Fiber mats exhibit excellent mechanical stability against rinsing, and support the incubation of epithelial (skin) and pancreatic cells. Impedance spectroscopy on the whole-cell sensor shows resistive changes attributed to cell growth as well as complex frequency

  5. Offshore Minerals Management Platforms for the Gulf of Mexico (GOM), Geographic NAD83, MMS (2006) [platforms_mms_2006

    Data.gov (United States)

    Louisiana Geographic Information Center — Offshore Minerals Management Platforms for the Gulf of Mexico (GOM). Identifies the location of platforms in GOM. All platforms existing in the database are included.

  6. Creating Math Videos: Comparing Platforms and Software

    Science.gov (United States)

    Abbasian, Reza O.; Sieben, John T.

    2016-01-01

    In this paper we present a short tutorial on creating mini-videos using two platforms--PCs and tablets such as iPads--and software packages that work with these devices. Specifically, we describe the step-by-step process of creating and editing videos using a Wacom Intuos pen-tablet plus Camtasia software on a PC platform and using the software…

  7. Distributed E-Service Platform Model

    Institute of Scientific and Technical Information of China (English)

    PING Hu; YANG Hua; CHEN Jia-xun

    2002-01-01

    E-communication is an internet-oriented application platform for distributed system. The architecture of the platform is discussed in detail in this article. By theory and case study, the distributed model is proved flexible and practicable. Using services and core, developers can extend the e-community and leverage their applications.This model will be great helpful to build a new kind distributed, java-based, internet application.

  8. Virtual health platform for medical tourism purposes.

    Science.gov (United States)

    Martinez, Debora; Ferriol, Pedro; Tous, Xisco; Cabrer, Miguel; Prats, Mercedes

    2008-01-01

    This paper introduces an overview of the Virtual Health Platform (VHP), an alternative approach to create a functional PHR system in a medical tourism environment. The proposed platform has been designed in order to be integrated with EHR infrastructures and in this way it expects to be useful and more advantageous to the patient or tourist. Use cases of the VHP and its potential benefits summarize the analysis.

  9. Creating Math Videos: Comparing Platforms and Software

    Science.gov (United States)

    Abbasian, Reza O.; Sieben, John T.

    2016-01-01

    In this paper we present a short tutorial on creating mini-videos using two platforms--PCs and tablets such as iPads--and software packages that work with these devices. Specifically, we describe the step-by-step process of creating and editing videos using a Wacom Intuos pen-tablet plus Camtasia software on a PC platform and using the software…

  10. Handheld Microneedle-Based Electrolyte Sensing Platform.

    Energy Technology Data Exchange (ETDEWEB)

    Miller, Philip R. [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Rivas, Rhiana [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Johnson, David [Aquila Technologies Group, Inc., Albuquerque, NM (United States); Edwards, Thayne L. [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Koskelo, Markku [Aquila Technologies Group, Inc., Albuquerque, NM (United States); Shawa, Luay [Aquila Technologies Group, Inc., Albuquerque, NM (United States); Brener, Igal [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Chavez, Victor H. [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Polsky, Ronen [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States)

    2015-11-01

    Sandia National Laboratories will provide technical assistance, within time and budget, to Requester on testing and analyzing a microneedle-based electrolyte sensing platform. Hollow microneedles will be fabricated at Sandia and integrated with a fluidic chip using plastic laminate prototyping technology available at Sandia. In connection with commercial ion selective electrodes the sensing platform will be tested for detection of electrolytes (sodium and/or potassium) within physiological relevant concent ration ranges.

  11. Flexible optical chemical sensor platform for BTX

    OpenAIRE

    Arias Espinoza, Juan Diego; Sazhnikov, Viacheslav; Sabik, Sami; Ionov, Dmitriy; Smits, Edsger; Kalathimekkad, Sandeep; Van Steenberge, Geert; Alfimov, Michail; Posniak, Malgorzata; Schoo, Herman

    2012-01-01

    An in-plane flexible sensor platform for BTX detection was developed using low-cost patterning techniques and foil-based optical components. The platform was produced by a combination of laser patterning, inkjet printing and capillary filling. Key optical components such as lightguides, opticalcladding layers and metallic interconnections were realized on low cost substrates such as paper and PET. The sensing mechanism is based on the change in fluorescence spectra of a reporter dye, supporte...

  12. SCEC Broadband Platform Strong Ground Motion Simulations

    Science.gov (United States)

    Kumar, S.; Callaghan, S.; Maechling, P. J.; Olsen, K. B.; Archuleta, R. J.; Somerville, P. G.; Graves, R. W.; Jordan, T. H.; Broadband Platform Working Group

    2011-12-01

    The Southern California Earthquake Center (SCEC) Broadband Platform is a collaborative software development project involving SCEC researchers, graduate students, and the SCEC Community Modeling Environment. The goal of the SCEC Broadband Simulation Platform is to generate broadband (0-10 Hz) ground motions for earthquakes using deterministic low-frequency and stochastic high-frequency simulations. SCEC developers have integrated complex scientific modules for rupture generation, low-frequency deterministic seismogram synthesis, high-frequency stochastic seismogram synthesis, and non-linear site effects calculation into a system that supports easy on-demand computation of broadband seismograms. The SCEC Broadband platform has two primary modes of operation, validation mode, and scenario mode. In validation mode, the earthquake modeling software calculates broadband seismograms for one of three earthquakes, Northridge, Loma Prieta, or Landers at sites with observed strong motion data. Then, the platform calculates goodness of fit measurements that quantify how well the model-based broadband seismograms match the observed seismograms for each event. In scenario mode, the user can specify a scenario earthquake and a list of sites and calculate ground motions at each site for the scenario event. In February 2011, SCEC released Broadband Platform 11.2 as an open-source scientific software distribution. Since that time, we have continued development of the platform by adding a new site response module and new goodness of fit measures by Mayhew and Olsen. Along with a source code distribution of the Broadband Platform, we now offer a virtual software image distribution of the platform to support its use on a variety of computing hardware and operating systems.

  13. Interfacing Clojure with Pogamut 3 platform

    Science.gov (United States)

    Gołuński, Marcel; WÄ siewicz, Piotr

    In this paper we present an interface between Pogamut 3 platform and Clojure programming language. Clojure is a state of the art functional language with roots in Lisp. Pogamut 3 is a framework that simplifies creation of embodied agents. Our goal was to introduce Clojure code in our agents logic. Simple emergent behavior of a group of agents was implemented using Clojure code. Performance of execution of Clojure code called from Pogamut platform was measured.

  14. The design and analysis of the mechanical property test platform frame for marine structures

    Directory of Open Access Journals (Sweden)

    Wen-xian Tang

    2016-01-01

    Full Text Available In order to realize mechanical properties test of the emergency towing arrangements, anchor chain and other large marine components, a large-tonnage and multi-function horizontal tension test platform is put forward in this paper. The paper analyzes the disadvantages of the frame structure of the existing experimental platform and designs the composite structure of the concrete and steel. The steel has good elasticity and toughness, the concrete has good performance of high rigidity and compression resistance, so the composite structure takes the advantages of both. The sharp of the frame is like “L”, which can be used to testing different projects. The paper gives the detailed size and analysis procedure of the frame. And it finds a more reasonable structure by means of finite element to analyze and optimize. The frame structure has the advantages of low weight and cost. The platform has been installed in Zhoushan, China successfully.

  15. Study on Collision Characters for SPAR Platform

    Institute of Scientific and Technical Information of China (English)

    HU Zhi-qiang; CUI Wei-cheng

    2008-01-01

    This paper presents the research on the external mechanism of collision characters for a SPAR platform. The collision characters of SPAR platform have not attracted so much attention as that of ships in the past, because short of this kind of collision accidents reported. But with the increasing number of SPAR platforms in the world, the possibility of such kind of accident also increases. Therefore, it is necessary to master the character of SPAR collision. Model test technique is employed to study the external mechanism. The collision scenario is a ship colliding with a SPAR platform moored in the site with 1500 meters water depth. The striking ship hits the SPAR platform on the hard tank near water surface in its longitudinal direction. The specifics of the SPAR's motions and the tension forces of the mooring lines are collected to summarize the hydrodynamic characters in the collision scenario. It is found that the maximal displacements and the maximal pitch angles of the SPAR platform, and the maximal tension forces of mooring lines are all linearly proportional to the initial velocity of the striking ship basically. Mooring lines play elastic roles in the collision course.

  16. Drug regimens identified and optimized by output-driven platform markedly reduce tuberculosis treatment time

    Science.gov (United States)

    Lee, Bai-Yu; Clemens, Daniel L.; Silva, Aleidy; Dillon, Barbara Jane; Masleša-Galić, Saša; Nava, Susana; Ding, Xianting; Ho, Chih-Ming; Horwitz, Marcus A.

    2017-01-01

    The current drug regimens for treating tuberculosis are lengthy and onerous, and hence complicated by poor adherence leading to drug resistance and disease relapse. Previously, using an output-driven optimization platform and an in vitro macrophage model of Mycobacterium tuberculosis infection, we identified several experimental drug regimens among billions of possible drug-dose combinations that outperform the current standard regimen. Here we use this platform to optimize the in vivo drug doses of two of these regimens in a mouse model of pulmonary tuberculosis. The experimental regimens kill M. tuberculosis much more rapidly than the standard regimen and reduce treatment time to relapse-free cure by 75%. Thus, these regimens have the potential to provide a markedly shorter course of treatment for tuberculosis in humans. As these regimens omit isoniazid, rifampicin, fluoroquinolones and injectable aminoglycosides, they would be suitable for treating many cases of multidrug and extensively drug-resistant tuberculosis. PMID:28117835

  17. Lantibiotic resistance.

    Science.gov (United States)

    Draper, Lorraine A; Cotter, Paul D; Hill, Colin; Ross, R Paul

    2015-06-01

    The dramatic rise in the incidence of antibiotic resistance demands that new therapeutic options will have to be developed. One potentially interesting class of antimicrobials are the modified bacteriocins termed lantibiotics, which are bacterially produced, posttranslationally modified, lanthionine/methyllanthionine-containing peptides. It is interesting that low levels of resistance have been reported for lantibiotics compared with commercial antibiotics. Given that there are very few examples of naturally occurring lantibiotic resistance, attempts have been made to deliberately induce resistance phenotypes in order to investigate this phenomenon. Mechanisms that hinder the action of lantibiotics are often innate systems that react to the presence of any cationic peptides/proteins or ones which result from cell well damage, rather than being lantibiotic specific. Such resistance mechanisms often arise due to altered gene regulation following detection of antimicrobials/cell wall damage by sensory proteins at the membrane. This facilitates alterations to the cell wall or changes in the composition of the membrane. Other general forms of resistance include the formation of spores or biofilms, which are a common mechanistic response to many classes of antimicrobials. In rare cases, bacteria have been shown to possess specific antilantibiotic mechanisms. These are often species specific and include the nisin lytic protein nisinase and the phenomenon of immune mimicry.

  18. Spatially selective surface platforms for binding fibrinogen prepared by particle lithography with organosilanes

    OpenAIRE

    Englade-Franklin, Lauren E.; Saner, ChaMarra K.; Garno, Jayne C.

    2013-01-01

    We introduce an approach based on particle lithography to prepare spatially selective surface platforms of organosilanes that are suitable for nanoscale studies of protein binding. Particle lithography was applied for patterning fibrinogen, a plasma protein that has a major role in the clotting cascade for blood coagulation and wound healing. Surface nanopatterns of mercaptosilanes were designed as sites for the attachment of fibrinogen within a protein-resistant matrix of 2-[methoxy(polyethy...

  19. Nonlinear Behavior of Single Piles in Jacket Type Offshore Platforms Using Incremental Dynamic Analysis

    Directory of Open Access Journals (Sweden)

    Mohammad A. Assareh

    2008-01-01

    Full Text Available The operation for offshore oil has become an important issue in the recent years. Offshore platforms are some of those structures which are built to withstand environmental and accidental loads during oil exploitation operation. One of the most usual types of these platforms is the Jacket Type Offshore Platform (JTOP which can be divided into three important parts, which are Deck, Jacket and piles. In order to increase the safety, particular attention should be paid to earthquake excitations which are directly applied to the piles of these structures. Nonlinearity in piles and buckling of the struts are important issues which have to be considered by the designers of offshore platforms. The case of nonlinearity in piles and failure capture in these members has not effectively been covered by researchers. Incremental Dynamic Analysis (IDA is a powerful tool to assess the capacity of a structure upon seismic loads. In this paper incremental dynamic analysis has been implemented on single piles considering soil-pile interactions and free field site response. The use of nonlinear materials and lateral load resisting elements in the incremental dynamic analysis done in this paper has made it possible to get promising insights for incorporation of appropriate limit states and applications of performance based engineering. Special Engineering Demand Parameters (EDP and Intensity Measures (IM have been introduced for the single pile dynamic analysis in jacket type offshore platforms.

  20. A Multichannel Calorimetric Simultaneous Assay Platform Using a Microampere Constant-Current Looped Enthalpy Sensor Array

    Science.gov (United States)

    Wei, Hsien-Chin; Huang, Su-Hua; Jiang, Joe-Air; Lee, Yeun-Chung

    2017-01-01

    Calorimetric biochemical measurements offer various advantages such as low waste, low cost, low sample consumption, short operating time, and labor-savings. Multichannel calorimeters can enhance the possibility of performing higher-throughput biochemical measurements. An enthalpy sensor (ES) array is a key device in multichannel calorimeters. Most ES arrays use Wheatstone bridge amplifiers to condition the sensor signals, but such an approach is only suitable for null detection and low resistance sensors. To overcome these limitations, we have developed a multichannel calorimetric simultaneous assay (MCSA) platform. An adjustable microampere constant-current (AMCC) source was designed for exciting the ES array using a microampere current loop measurement circuit topology. The MCSA platform comprises a measurement unit, which contains a multichannel calorimeter and an automatic simultaneous injector, and a signal processing unit, which contains multiple ES signal conditioners and a data processor. This study focused on the construction of the MCSA platform; in particular, construction of the measurement circuit and calorimeter array in a single block. The performance of the platform, including current stability, temperature sensitivity and heat sensitivity, was evaluated. The sensor response time and calorimeter constants were given. The capability of the platform to detect relative enzyme activity was also demonstrated. The experimental results show that the proposed MCSA is a flexible and powerful biochemical measurement device with higher throughput than existing alternatives. PMID:28165412

  1. A Multichannel Calorimetric Simultaneous Assay Platform Using a Microampere Constant-Current Looped Enthalpy Sensor Array

    Directory of Open Access Journals (Sweden)

    Hsien-Chin Wei

    2017-02-01

    Full Text Available Calorimetric biochemical measurements offer various advantages such as low waste, low cost, low sample consumption, short operating time, and labor-savings. Multichannel calorimeters can enhance the possibility of performing higher-throughput biochemical measurements. An enthalpy sensor (ES array is a key device in multichannel calorimeters. Most ES arrays use Wheatstone bridge amplifiers to condition the sensor signals, but such an approach is only suitable for null detection and low resistance sensors. To overcome these limitations, we have developed a multichannel calorimetric simultaneous assay (MCSA platform. An adjustable microampere constant-current (AMCC source was designed for exciting the ES array using a microampere current loop measurement circuit topology. The MCSA platform comprises a measurement unit, which contains a multichannel calorimeter and an automatic simultaneous injector, and a signal processing unit, which contains multiple ES signal conditioners and a data processor. This study focused on the construction of the MCSA platform; in particular, construction of the measurement circuit and calorimeter array in a single block. The performance of the platform, including current stability, temperature sensitivity and heat sensitivity, was evaluated. The sensor response time and calorimeter constants were given. The capability of the platform to detect relative enzyme activity was also demonstrated. The experimental results show that the proposed MCSA is a flexible and powerful biochemical measurement device with higher throughput than existing alternatives.

  2. Integrated microfluidic platforms for investigating neuronal networks

    Science.gov (United States)

    Kim, Hyung Joon

    This dissertation describes the development and application of integrated microfluidics-based assay platforms to study neuronal activities in the nervous system in-vitro. The assay platforms were fabricated using soft lithography and micro/nano fabrication including microfluidics, surface patterning, and nanomaterial synthesis. The use of integrated microfluidics-based assay platform allows culturing and manipulating many types of neuronal tissues in precisely controlled microenvironment. Furthermore, they provide organized multi-cellular in-vitro model, long-term monitoring with live cell imaging, and compatibility with molecular biology techniques and electrophysiology experiment. In this dissertation, the integrated microfluidics-based assay platforms are developed for investigation of neuronal activities such as local protein synthesis, impairment of axonal transport by chemical/physical variants, growth cone path finding under chemical/physical cues, and synaptic transmission in neuronal circuit. Chapter 1 describes the motivation, objectives, and scope for developing in-vitro platform to study various neuronal activities. Chapter 2 introduces microfluidic culture platform for biochemical assay with large-scale neuronal tissues that are utilized as model system in neuroscience research. Chapter 3 focuses on the investigation of impaired axonal transport by beta-Amyloid and oxidative stress. The platform allows to control neuronal processes and to quantify mitochondrial movement in various regions of axons away from applied drugs. Chapter 4 demonstrates the development of microfluidics-based growth cone turning assay to elucidate the mechanism underlying axon guidance under soluble factors and shear flow. Using this platform, the behaviors of growth cone of mammalian neurons are verified under the gradient of inhibitory molecules and also shear flow in well-controlled manner. In Chapter 5, I combine in-vitro multicellular model with microfabricated MEA

  3. Embedded Linux platform for data acquisition systems

    Energy Technology Data Exchange (ETDEWEB)

    Patel, Jigneshkumar J., E-mail: jjp@ipr.res.in [Institute for Plasma Research, Gandhinagar, Gujarat (India); Reddy, Nagaraj, E-mail: nagaraj.reddy@coreel.com [Sandeepani School of Embedded System Design, Bangalore, Karnataka (India); Kumari, Praveena, E-mail: praveena@ipr.res.in [Institute for Plasma Research, Gandhinagar, Gujarat (India); Rajpal, Rachana, E-mail: rachana@ipr.res.in [Institute for Plasma Research, Gandhinagar, Gujarat (India); Pujara, Harshad, E-mail: pujara@ipr.res.in [Institute for Plasma Research, Gandhinagar, Gujarat (India); Jha, R., E-mail: rjha@ipr.res.in [Institute for Plasma Research, Gandhinagar, Gujarat (India); Kalappurakkal, Praveen, E-mail: praveen.k@coreel.com [Sandeepani School of Embedded System Design, Bangalore, Karnataka (India)

    2014-05-15

    Highlights: • The design and the development of data acquisition system on FPGA based reconfigurable hardware platform. • Embedded Linux configuration and compilation for FPGA based systems. • Hardware logic IP core and its Linux device driver development for the external peripheral to interface it with the FPGA based system. - Abstract: This scalable hardware–software system is designed and developed to explore the emerging open standards for data acquisition requirement of Tokamak experiments. To address the future need for a scalable data acquisition and control system for fusion experiments, we have explored the capability of software platform using Open Source Embedded Linux Operating System on a programmable hardware platform such as FPGA. The idea was to identify the platform which can be customizable, flexible and scalable to support the data acquisition system requirements. To do this, we have selected FPGA based reconfigurable and scalable hardware platform to design the system with Embedded Linux based operating system for flexibility in software development and Gigabit Ethernet interface for high speed data transactions. The proposed hardware–software platform using FPGA and Embedded Linux OS offers a single chip solution with processor, peripherals such ADC interface controller, Gigabit Ethernet controller, memory controller amongst other peripherals. The Embedded Linux platform for data acquisition is implemented and tested on a Virtex-5 FXT FPGA ML507 which has PowerPC 440 (PPC440) [2] hard block on FPGA. For this work, we have used the Linux Kernel version 2.6.34 with BSP support for the ML507 platform. It is downloaded from the Xilinx [1] GIT server. Cross-compiler tool chain is created using the Buildroot scripts. The Linux Kernel and Root File System are configured and compiled using the cross-tools to support the hardware platform. The Analog to Digital Converter (ADC) IO module is designed and interfaced with the ML507 through Xilinx

  4. Remote control of a mobile platform with a smartphone

    OpenAIRE

    Majcen, Gregor

    2011-01-01

    This thesis describes a system for remote control of a mobile platform using a smartphone. As a mobile platform is used an iRobot Roomba vacuum cleaner equipped with a wireless router and a camera. The mobile platform and the smartphone communicate over the internet. The smartphone is used as a gaming console to control the movement of the mobile platform.

  5. Demand Heterogeneity and the Adoption of Platform Complements

    NARCIS (Netherlands)

    J. Rietveld (Joost); J.P. Eggers

    2016-01-01

    textabstractThis paper offers a demand-based theory of how platform maturity affects the adoption of platform complements. We argue that differences between early and late adopters of the platform include willingness to pay for the platform-and-complement bundle, risk preferences, preference for

  6. Demand Heterogeneity and the Adoption of Platform Complements

    NARCIS (Netherlands)

    J. Rietveld (Joost); J.P. Eggers

    2016-01-01

    textabstractThis paper offers a demand-based theory of how platform maturity affects the adoption of platform complements. We argue that differences between early and late adopters of the platform include willingness to pay for the platform-and-complement bundle, risk preferences, preference for nov

  7. ROHDIP: Resource Oriented Heterogeneous Data Integration Platform

    Directory of Open Access Journals (Sweden)

    Wael Shehab

    2016-09-01

    Full Text Available During the last few years, the revolution of social networks such as Facebook, Twitter, and Instagram led to a daily increasing of data that are heterogeneous in their sources, data models, and platforms. Heterogeneous data sources have many forms such as the www, deep web, relational databases systems, No-SQL database systems, hierarchal data systems, semi-structured files, in which data are usually allocated on different machines (distributed and have different data models (heterogeneous. Large-scale data integration efforts demonstrate that their most valuable contribution is implementing a data integration platform that provides a uniform access to the heterogeneous data sources, as well as the different versions of data reported by the same data source over time. Furthermore, the platform must be able to integrate data from a broad range of data authoring devices and database management systems. It also should be accessible by almost types of data querying devices to ensure globally querying the integration platform from any place on earth anytime and receiving the query result in any data format. In this paper, we create a resource oriented heterogeneous data integration platform (ROHDIP that facilitates the data integration process and implements the objectives discussed above. We use the resource oriented architecture ROA to support the uniform access by most types of data querying devices from anywhere and to improve the query response time.

  8. Anticipating Alternative Futures for the Platform Economy

    Directory of Open Access Journals (Sweden)

    Mikko Dufva

    2017-09-01

    Full Text Available Despite the considerable hype around platforms, our understanding of what the platform economy means and what drivers will define future development trajectories is limited. Companies and policy makers have a great need to investigate what potential opportunities will arise from the platform economy. A shared perception of uncertainties and a strong vision are prerequisites for the development of the platform economy. In this article, we describe a systematic way to develop a resilient vision for a new platform ecosystem, both from the viewpoint of national policy makers and corporate strategy makers in the heavy engineering industry. The process uses morphological analysis for scenario development and robust portfolio modelling for creating resilient strategies. The results include a list of key uncertainties, three general scenarios (sustainable development by Europe; polarization driven by China and the United States; US-driven fast, unreliable growth as well as steel-industry specific scenarios based on these uncertainties, elements of a resilient vision, and strategies for coping with the uncertainties described by the scenarios.

  9. Vessel, motion platform, method for compensating motions of a vessel and use of a stewart platform

    NARCIS (Netherlands)

    Van der Tempel, J.; Salzmann, D.J.C.; Koch, J.; Gerner. F.; Goebel, A.J.

    2007-01-01

    A vessel (1) with a motion compensation platform (4), which platform is provided with at least one carrier (6) for bearing, moving and/or transferring a load, actuators (5) for moving the carrier relative to the vessel, preferably in six degrees of freedom, a control system for driving the actuators

  10. A comparative study of submicron particle sizing platforms: accuracy, precision and resolution analysis of polydisperse particle size distributions.

    Science.gov (United States)

    Anderson, Will; Kozak, Darby; Coleman, Victoria A; Jämting, Åsa K; Trau, Matt

    2013-09-01

    The particle size distribution (PSD) of a polydisperse or multimodal system can often be difficult to obtain due to the inherent limitations in established measurement techniques. For this reason, the resolution, accuracy and precision of three new and one established, commercially available and fundamentally different particle size analysis platforms were compared by measuring both individual and a mixed sample of monodisperse, sub-micron (220, 330, and 410 nm - nominal modal size) polystyrene particles. The platforms compared were the qNano Tunable Resistive Pulse Sensor, Nanosight LM10 Particle Tracking Analysis System, the CPS Instruments's UHR24000 Disc Centrifuge, and the routinely used Malvern Zetasizer Nano ZS Dynamic Light Scattering system. All measurements were subjected to a peak detection algorithm so that the detected particle populations could be compared to 'reference' Transmission Electron Microscope measurements of the individual particle samples. Only the Tunable Resistive Pulse Sensor and Disc Centrifuge platforms provided the resolution required to resolve all three particle populations present in the mixed 'multimodal' particle sample. In contrast, the light scattering based Particle Tracking Analysis and Dynamic Light Scattering platforms were only able to detect a single population of particles corresponding to either the largest (410 nm) or smallest (220 nm) particles in the multimodal sample, respectively. When the particle sets were measured separately (monomodal) each platform was able to resolve and accurately obtain a mean particle size within 10% of the Transmission Electron Microscope reference values. However, the broadness of the PSD measured in the monomodal samples deviated greatly, with coefficients of variation being ~2-6-fold larger than the TEM measurements across all four platforms. The large variation in the PSDs obtained from these four, fundamentally different platforms, indicates that great care must still be taken in

  11. Resident resistance.

    Science.gov (United States)

    Price, J L; Cleary, B

    1999-01-01

    Clearly, faculty must work hard with residents to explore the nature of their resistance to a program's learning and growth opportunities. Initial steps to a deeper, more effective, and longer-lasting change process must be pursued. If resident resistance is mishandled or misunderstood, then learning and professional growth may be sidetracked and the purposes of residency training defeated. Listening to the whole person of the resident and avoiding the trap of getting caught up in merely responding to select resident behaviors that irritate us is critical. Every faculty member in the family practice residency program must recognize resistance as a form of defense that cannot immediately be torn down or taken away. Resident defenses have important purposes to play in stress reduction even if they are not always healthy. Residents, especially interns, use resistance to avoid a deeper and more truthful look at themselves as physicians. A family practice residency program that sees whole persons in their residents and that respects resident defenses will effectively manage the stress and disharmony inherent to the resistant resident.

  12. Communication System for CIMS Application Integration Platform

    Institute of Scientific and Technical Information of China (English)

    1999-01-01

    CIMS has seen the growth of multiple incompatible hardware architectur es, each architecture supporting several incompatible operating systems, and eac h platform operating with various incompatible development tools (e.g., programm ing language compilers, DBMS, etc.) and one or more incompatible graphic user in terfaces. Also, the growth of the Internet, the World-Wide Web, has introduced new dimensio ns of complexity into the development process. All of these must be dealt with a s the application is made workable in a distributed client-server environment. This paper outlines the architecture of a communication system for the CIMS appl ication integration platform. The communication system makes possible the reque st for service across heterogeneous platforms and networks, and provides some co mmon solutions to issues common to CIMS applications.

  13. GAVIP: A Platform for Gaia Data Analysis

    CERN Document Server

    Vagg, Daniel; hÓgáin, Fionn Ó; McBreen, Sheila; Hanlon, Lorraine; Lynn, David; O'Mullane, William

    2016-01-01

    Gaia is a major European Space Agency (ESA) astrophysics mission designed to map and analyse 10$^9$ stars, ultimately generating more than 1 PetaByte of data products. As Gaia data becomes publicly available and reaches a wider audience, there is an increasing need to facilitate the further use of Gaia products without needing to download large datasets. The Gaia Added Value Interface Platform (GAVIP) is designed to address this challenge by providing an innovative platform within which scientists can submit and deploy code, packaged as "Added Value Interfaces" (AVIs), which will be executed close to the data. Deployed AVIs and associated outputs may also be made available to other GAVIP platform users, thus providing a mechanism for scientific experiment reproducibility. This paper describes the capabilities and features of GAVIP.

  14. The FLP microsatellite platform flight operations manual

    CERN Document Server

    2016-01-01

    This book represents the Flight Operations Manual for a reusable microsatellite platform – the “Future Low-cost Platform” (FLP), developed at the University of Stuttgart, Germany. It provides a basic insight on the onboard software functions, the core data handling system and on the power, communications, attitude control and thermal subsystem of the platform. Onboard failure detection, isolation and recovery functions are treated in detail. The platform is suited for satellites in the 50-150 kg class and is baseline of the microsatellite “Flying Laptop” from the University. The book covers the essential information for ground operators to controls an FLP-based satellite applying international command and control standards (CCSDS and ECSS PUS). Furthermore it provides an overview on the Flight Control Center in Stuttgart and on the link to the German Space Agency DLR Ground Station which is used for early mission phases. Flight procedure and mission planning chapters complement the book. .

  15. Development of a Zigbee platform for bioinstrumentation.

    Science.gov (United States)

    Cifuentes, Carlos A; Gentiletti, Gabriel G; Suarez, Marco J; Rodriguez, Luis E

    2010-01-01

    This paper presents the development of a network platform which allows connecting multiple individual wireless devices for transmitting bioelectrics and biomechanics signals for application in a hospital network, or continuous monitoring in a patient's diary life. The Zigbee platform development proposal was made in three stages: 1) Hardware development, including the construction of a prototype network node and the integration of sensors, (2) Evaluation, in order to define the specifications of each node and scope of communication and (3) The Zigbee Network Implementation for bioinstrumentation based on ZigBee Health Care public application profile (ZHC). Finally, this work presents the experimental results based on measurements of Lost Packets and LQI (Link Quality Indicator), and the Zigbee Platform configuration for Bioinstrumentation in operation.

  16. Electronics Platform of PS Linac 1 Preinjector

    CERN Multimedia

    1974-01-01

    For servicing during shutdowns, a draw-bridge from a door in the Faraday cage led to the "electronics platform" of the linac 1 preinjector (at 520 kV when in operation) and the top of the electronics platform was lifted on hydraulic jacks for easy access. Henry Charmot is busy with a service. The platform contained the electronics for the ion source, controlled from outside the Faraday cage via an infrared optical link. The ion source, also at 520 kV potential, is housed in the drum, visible in the background, on the insulator column, which at its right end is mounted at ground potential. Behind the wall, to the right, is the 50 MeV linac 1. See also 7403064X, 7403066X, 7403124.

  17. An Experimental Study of an Offshore Platform

    DEFF Research Database (Denmark)

    Brincker, Rune; Asmussen, John Christian; Andersen, Palle

    This report describes the results of an analysis of the ambient response data collected from a Venezuelan near-shore offshore platform constructed in 1992. Recording of the data have been constantly done during the period from May 1993 to July 1994. Using these data the structural integrity...... of the multi-pile offshore platform is investigated by using a vibration based damage detection scheme. Changes in structural integrity are assumed to be reflected in the modal parameters estimated from only output data using an Auto-Regressive Moving Average (ARMA) model. Before the calibration of the ARMA...... model the quality of the measured data have been investigated. The estimated modal parameters and their corresponding variances are used as input to a probability based damage indicator. This indicator indicates, that since the construction of the platform, minor structural changes have taken place....

  18. Thermal performance testing of the Explorer Platform

    Science.gov (United States)

    Wasson, David; Ducas, William; Ousley, Wes

    1993-01-01

    The Explorer Platform (EP) has been designed to accommodate on-orbit payload and bus module changeout via Space Transportation System (STS) servicing. Such a versatile spacecraft platform designed to experience widely different environmental exposures and operational conditions, coupled with program constraints on schedule and budget, presented a challenge to implementing a technically sound thermal vacuum/thermal balance test program. This paper discusses thermal performance tests implemented at the subsystem and system levels, and the risks accepted resulting from test sequence, configuration. and tests omitted from the program. No thermal cycling or thermal balance tests were performed on the integrated spacecraft level, although both the Payload (EUVE) and Platform (EP) received independent testing. The decision to take this approach is discussed with respect to the thermal design and the associated risks taken to maintain budget and schedule.

  19. Azimut: a multimodal locomotion robotic platform

    Science.gov (United States)

    Michaud, Francois; Letourneau, Dominic; Arsenault, Martin; Bergeron, Yann; Cadrin, Richard; Gagnon, Frederic; Legault, Marc-Antoine; Millette, Mathieu; Pare, Jean-Francois; Tremblay, Marie-Christine; Lepage, Pierre; Morin, Yan; Caron, Serge

    2003-09-01

    Other than from its sensing and processing capabilities, a mobile robotic platform can be limited in its use by its ability to move in the environment. A wheeled robot works well on flat surfaces. Tracks are useful over rough terrains, while legs allow a robot to move over obstacles. In this paper we present a new concept of mobile robot with the objective of combining different locomotion mechanisms on the same platform to increase its locomotion capabilities. After presenting a review of multi-modal robotic platforms, we describe the design of our robot called AZIMUT. AZIMUT combines wheels, legs and tracks to move in three-dimensional environments. The robot is symmetrical and is made of four independent leg-track-wheel articulations. It can move with its articulations up, down or straight, or move sideways without changing the robot's orientation. The robot could be used in surveillance and rescue missions, exploration or operation in hazardous environments.

  20. Media content management on the DTV platform

    Science.gov (United States)

    Yeo, Boon-Lock; Yeung, Minerva M.

    1998-12-01

    Digital TV offers many advantages over analog TV. The obvious advantages are higher picture resolution and superior quality, more programs for the same channel bandwidth, and potential for mixed video and data broadcasting. In addition, the reception of video, audio, and data in digital form, offer new opportunities for better filtering, management and organization of the content, during and after the broadcast. The platform on which these media content management operations are performed is similar to the computing platform, with which we are familiar. Hence, the goals are to process incoming bits of data and to generate output for users' reception and/or interactivity. In this paper, we present our vision and summarize our research activities in media content management on the DTV platform. In particular, we will focus on three key areas, namely, channel surfing, digital video recording, and content filtering. We will also demonstrate how media content management can offer new and better viewing experiences in the era of DTV.

  1. Design for game based learning platforms

    DEFF Research Database (Denmark)

    Sørensen, Birgitte Holm; Meyer, Bente

    2010-01-01

    This paper focuses on the challenges related to the design of game based learning platforms for formal learning contexts that are inspired by the pupil's leisure time related use of web 2.0. The paper is based on the project Serious Games on a Global Market Place (2007-2011) founded by the Danish...... Council for Strategic Research, in which an online game-based platform for English as a foreign language in primary school is studied. The paper presents a model for designing for game based learning platforms. This design is based on cultural and ethnographic based research on children's leisure time use...... of web 2.0 and integrates theories of learning, didactics, games, play, communication, multimodality and different pedagogical approaches. In relation to the introduced model the teacher role is discussed....

  2. What are the key sucess factors of MOOC platforms?

    OpenAIRE

    Bento, Lourenço de Moura Souto

    2014-01-01

    This thesis analyzes key characteristics of Massive Open Online Courses (MOOCs) platforms in order to assess what makes such platforms successful. Three challenges of MOOC platforms were determined from the review of the literature: dropout rates, sustainability and plagiarism. Primary data was gathered from a sample of MOOC platforms, both on the characteristics of the platforms themselves and their internet traffic data. We performed a statistical correlation analysis using Traffic Rank as ...

  3. CONFIGURATION DEVELOPMENT ON THE PLATFORM 1C FOR ENTERPRISE AUTOMATION

    OpenAIRE

    О.L. LIAKHOV; T.A. DMYTRENKO; A.О. TVERDOKHLIB; T.M. DERKACH; A.O. DMYTRENKO

    2015-01-01

    In this paper, the results of configuration development on the platform 1C for limited liability companies were presented. The object of study is the development process configuration platform 1C. The purpose of the study is the technological platform “1C: Enterprise”. The tasks included analyzing the technological platform “1C: Enterprise”, comparing the most popular ERP-systems, configurator devel-opment on the platform 1C. Such research methods as structured programming techniques and meth...

  4. The macrofouling on offshore platforms at Ravenna

    Energy Technology Data Exchange (ETDEWEB)

    Relini, G.; Tixi, F.; Relini, M.; Torchia, G. [Universita degli Studi di Genova-Istituto di Zoologia (Italy). Lab. di Biologia Marina e Ecologia Animale

    1998-12-31

    The fouling which settles on gas platform piles was studied using samples taken in 1993 from the PCWA and ANTARES platforms positioned, at 7 and 10.5 km from the shore respectively and on bottoms at 12 m and 14 m in the Adriatic Sea. For each platform a pile was chosen as representative of the macrofouling found on the whole platform. In March and September 1993 samples were obtained by scraping an area of 600 cm{sup 2} from three or four different aspects (North, East, South, West), at the same depth. Samples were taken at depths of 0.5, 5.5 and 12 m on PCWA and 0.5, 7 and 12 m on ANTARES. Photographs and video recordings taken over the whole length of the chosen pile were used for an additional description of the settlement. On both platforms the macrofouling was characterized by a dominance of mussels from sea surface to a depth of about 10m. Near the bottom of the bivalve Crassostrea gigas, barnacles, hydroids and serpulids were more important. The presence of the bryozoan Schizoporella errata (present only at ANTARES) and the zoanthid Epizoanthus arenaceus (present only at PCWA) were the main differences at this depth. The fouling, or mussel weights, of the two platforms were similar for the two seasons, even though the highest values were registered in September on PCWA (1m) with 1561.3 g/dm{sup 2}, of which 1553 g/dm{sup 2} comprised mussels. A comparison is drawn with a previous fouling experiment (which used one-year panels) carried out in 1975-76. (Author)

  5. PRIMA: A new, competitive small satellite platform

    Science.gov (United States)

    Galeazzi, Claudio

    2000-03-01

    ASI, the Italian Space Agency, is going to finance a developing of a small satellite platforms production line called PRIMA (Piattaforma Riconfigurabile Italiana Multi-Applicativa) with Alenia Aerospazio partnership as Prime Contractor and sub-contractors preferably chosen within the Italian Space Industries. The main objective of the program is to develop a multi-mission, easily adaptable Platform for LEO orbits, allowing rapid, efficient and low cost bus for applicative and scientific missions. The Italian national space plan foresees for the enf of 2001 the build up of the Skymed/Cosmo constellation as applicative Earth observation program plus a number of small scientific spacecraft with a rate of 2 missions each three years. To fulfil these schedules, the PRIMA platform should complete its development and qualification program in order to be ready for the first unit (protoqualification flight) to interface the first payload (Science or Applicative). The intrinsic modularity of PRIMA should allow it to adapt itself to a large variety of missions in LEO orbits with minor modifications. The design will be conducted in order to get an advanced Platform able to meet a large set of missions, payloads and launcher specifications. The platform will be completed by a ground control centre adapted to the monitoring of PRIMA based satellites. PRIMA thus offers a very attractive alternative to large-scale missions in terms of costs and completion time. The paper will describe the technical aspects of PRIMA Platform, with particular emphasis put onto its flexibility and reconfigurability for different missions. The System and S/S architectures will also be presented and defined in view of selected mission cases. The AIV/AIT aspects will be discussed, with a discussion of the applicability of Globalstar™ approaches, facility and heritage. Finally, a brief overview of PRIMA first applications /SkyMed/COSMO and David) will be given.

  6. Emerging heterogeneous integrated photonic platforms on silicon

    Directory of Open Access Journals (Sweden)

    Fathpour Sasan

    2015-05-01

    Full Text Available Silicon photonics has been established as a mature and promising technology for optoelectronic integrated circuits, mostly based on the silicon-on-insulator (SOI waveguide platform. However, not all optical functionalities can be satisfactorily achieved merely based on silicon, in general, and on the SOI platform, in particular. Long-known shortcomings of silicon-based integrated photonics are optical absorption (in the telecommunication wavelengths and feasibility of electrically-injected lasers (at least at room temperature. More recently, high two-photon and free-carrier absorptions required at high optical intensities for third-order optical nonlinear effects, inherent lack of second-order optical nonlinearity, low extinction ratio of modulators based on the free-carrier plasma effect, and the loss of the buried oxide layer of the SOI waveguides at mid-infrared wavelengths have been recognized as other shortcomings. Accordingly, several novel waveguide platforms have been developing to address these shortcomings of the SOI platform. Most of these emerging platforms are based on heterogeneous integration of other material systems on silicon substrates, and in some cases silicon is integrated on other substrates. Germanium and its binary alloys with silicon, III–V compound semiconductors, silicon nitride, tantalum pentoxide and other high-index dielectric or glass materials, as well as lithium niobate are some of the materials heterogeneously integrated on silicon substrates. The materials are typically integrated by a variety of epitaxial growth, bonding, ion implantation and slicing, etch back, spin-on-glass or other techniques. These wide range of efforts are reviewed here holistically to stress that there is no pure silicon or even group IV photonics per se. Rather, the future of the field of integrated photonics appears to be one of heterogenization, where a variety of different materials and waveguide platforms will be used for

  7. AutoCAD platform customization autolisp

    CERN Document Server

    Ambrosius, Lee

    2014-01-01

    Customize and personalize programs built on the AutoCAD platform AutoLISP is the key to unlocking the secrets of a more streamlined experience using industry leading software programs like AutoCAD, Civil 3D, Plant 3D, and more. AutoCAD Platform Customization: AutoLISP provides real-world examples that show you how to do everything from modifying graphical objects and reading and setting system variables to communicating with external programs. It also features a resources appendix and downloadable datasets and customization examples-tools that ensure swift and easy adoption. Find out how to r

  8. Implementing Product Platforms: A Case Study

    DEFF Research Database (Denmark)

    Nielsen, Ole Fiil; Mortensen, Niels Henrik

    2006-01-01

    The paper describes a case study dealing with the process of creating and implementing a product platform. The paper espessially deals with the fact that to obtain the benefits of platforms a permanent change in behaviour in product development must be ensured. This change in behaviour requires...... acceptance and approval from the organisation in general and the commitment from management to enforce agreed-upon decisions. The case study itself was performed in the Danish company LEGO Group. The case study had two objectives: To create a technical architecture and align this architecture...

  9. Coupling methodology within the software platform alliances

    Energy Technology Data Exchange (ETDEWEB)

    Montarnal, Ph.; Deville, E.; Adam, E.; Bengaouer, A. [CEA Saclay, Dept. de Modelisation des Systemes et Structures 91 - Gif-sur-Yvette (France); Dimier, A.; Gaombalet, J.; Loth, L. [Agence Nationale pour la Gestion des Dechets Radioactifs (ANDRA), 92 - Chatenay Malabry (France); Chavant, C. [Electricite de France (EDF), 92 - Clamart (France)

    2005-07-01

    CEA, ANDRA and EDF are jointly developing the software platform ALLIANCES which aim is to produce a tool for the simulation of nuclear waste storage and disposal repository. This type of simulations deals with highly coupled thermo-hydro-mechanical and chemical (T-H-M-C) processes. A key objective of Alliances is to give the capability for coupling algorithms development between existing codes. The aim of this paper is to present coupling methodology use in the context of this software platform. (author)

  10. Tax responses in platform industries

    DEFF Research Database (Denmark)

    Kind, Hans Jarle; Köthenbürger, Marko; Schjelderup, Guttorm

    2010-01-01

    Two-sided platform firms serve distinct customer groups that are connected through interdependent demand, and include major businesses such as the media industry, banking, and the software industry. A well known result of tax incidence is that consumers of a more heavily taxed good pay a higher...... price and thus buy less of the good. The present paper shows that this result need not hold in a two-sided market. On the contrary, a higher ad valorem tax may lower end-user prices and spur sales. Thus, two-sided platform firms may not at all engage in tax shifting via price increases. We further show...

  11. An Open-Source Based ITS Platform

    DEFF Research Database (Denmark)

    Andersen, Ove; Krogh, Benjamin Bjerre; Torp, Kristian

    2013-01-01

    In this paper, a complete platform used to compute travel times from GPS data is described. Two approaches to computing travel time are proposed one based on points and one based on trips. Overall both approaches give reasonable results compared to existing manual estimated travel times. However......, the trip-based approach requires more GPS data and of a higher quality than the point-based approach. The platform has been completely implemented using open-source software. The main conclusion is that large quantity of GPS data can be managed, with a limited budget and that GPS data is a good source...

  12. Multi-platform Multiplayer RPG Game

    OpenAIRE

    Do Manh, Tuan

    2015-01-01

    Title: Multi-platform Multiplayer RPG Game A multi-platform game, which would be able to run on various devices with Windows 8.1 and Windows Phone 8.1 systems, was created in this work. It was supposed to be a universal game client executable on desktop PCs, notebooks, tablets or mobile phones. The game was supposed to be role-playing game (RPG) with focus on turn-based action combat. In this work, a 3D scene renderer was written which supports rendering simple scenes with objects and animate...

  13. AutoCAD platform customization VBA

    CERN Document Server

    Ambrosius, Lee

    2015-01-01

    Boost productivity and streamline your workflow with expert AutoCAD: VBA programming instruction AutoCAD Platform Customization: VBA is the definitive guide to personalizing AutoCAD and the various programs that run on the AutoCAD platform, including AutoCAD Architecture, Civil 3D, Plant 3D, and more. Written by an Autodesk insider with years of customization and programming experience, this book features detailed discussions backed by real-world examples and easy-to-follow tutorials that illustrate each step in the personalization process. Readers gain expert guidance toward managing layout

  14. Rheem: Enabling Multi-Platform Task Execution

    KAUST Repository

    Agrawal, Divy

    2016-06-16

    Many emerging applications, from domains such as healthcare and oil & gas, require several data processing systems for complex analytics. This demo paper showcases Rheem, a framework that provides multi-platform task execution for such applications. It features a three-layer data processing abstraction and a new query optimization approach for multi-platform settings. We will demonstrate the strengths of Rheem by using real-world scenarios from three different applications, namely, machine learning, data cleaning, and data fusion. © 2016 ACM.

  15. Platform for Distributed 3D Gaming

    OpenAIRE

    Jurgelionis, A; Fechteler, P.; Eisert, P.; Bellotti, F; David, H; Laulajainen, J. P.; Carmichael, R.; Poulopoulos, V.; A. Laikari; Perälä, P.; Gloria, A.; Bouras, C

    2009-01-01

    Video games are typically executed on Windows platforms with DirectX API and require high performance CPUs and graphics hardware. For pervasive gaming in various environments like at home, hotels, or internet cafes, it is beneficial to run games also on mobile devices and modest performance CE devices avoiding the necessity of placing a noisy workstation in the living room or costly computers/consoles in each room of a hotel. This paper presents a new cross-platform approach for distributed 3...

  16. Distributed hash table theory, platforms and applications

    CERN Document Server

    Zhang, Hao; Xie, Haiyong; Yu, Nenghai

    2013-01-01

    This SpringerBrief summarizes the development of Distributed Hash Table in both academic and industrial fields. It covers the main theory, platforms and applications of this key part in distributed systems and applications, especially in large-scale distributed environments. The authors teach the principles of several popular DHT platforms that can solve practical problems such as load balance, multiple replicas, consistency and latency. They also propose DHT-based applications including multicast, anycast, distributed file systems, search, storage, content delivery network, file sharing and c

  17. The ESA earth observation polar platform programme

    Science.gov (United States)

    Rast, M.; Readings, C. J.

    1991-08-01

    The overall scenario of ESA earth observation polar platform program is reviewed with particular attention given to instruments currently being considered for flight on the first European polar platforms. The major objectives of the mission include monitoring the earth's environment on various scales; management and monitoring of the earth's resources; improvement of the service provided to the worldwide operational meteorological community, investigation of the structure and dynamics of the earth's crust and interior. The program encompasses four main elements: an ERS-1 follow-on mission (ERS-2), a solid earth gravity mission (Aristoteles), a Meteosat Second Generation, and a series of polar orbit earth observation missions.

  18. Platform for a better built environment.

    Science.gov (United States)

    Baillie, Jonathan

    2014-08-01

    IHEEM's recently established Architecture and Design of the Built Environment Technical Platform (ADBETP) is now firmly up and running, and, as one of its members, Gary Mortimer, general manager, Facilities & Estates, at NHS Grampian, puts it, is 'determined to bring tangible, positive, and sustainable benefits to the NHS built environment to support the effective delivery of changing clinical needs'. Equally, the Platform hopes its activities will 'add value to IHEEM members, technical professionals in health construction and operational management, and other healthcare professionals working in NHS buildings'.

  19. A mobile and portable trusted computing platform

    Directory of Open Access Journals (Sweden)

    Nepal Surya

    2011-01-01

    Full Text Available Abstract The mechanism of establishing trust in a computing platform is tightly coupled with the characteristics of a specific machine. This limits the portability and mobility of trust as demanded by many emerging applications that go beyond the organizational boundaries. In order to address this problem, we propose a mobile and portable trusted computing platform in a form of a USB device. First, we describe the design and implementation of the hardware and software architectures of the device. We then demonstrate the capabilities of the proposed device by developing a trusted application.

  20. Multisensory platform based on NEC protocol

    Directory of Open Access Journals (Sweden)

    Novaković Đorđe

    2017-01-01

    Full Text Available Multisensory signal acquisition represents one of the main concepts necessary to perform measurements in various industrial and consumer-oriented applications. This paper presents a development platform which provides a data acquisition from multiple sensors. The main module of the platform is the UNIDS-3 development board with PIC18F8520 microcontroller. Data acquisition from the sensors is performed on user demand by remote control. NEC protocol is implemented and IR receiver TSOP31238 is used. The measurement data are sent to a computer, which performs digital data processing, data visualization and data storage. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. TR32019

  1. How Important is Export-Platform FDI?

    DEFF Research Database (Denmark)

    Geishecker, Ingo; Nielsen, Jørgen Ulff-Møller; Pawlik, Konrad

    on the respective export performance of Polish industries, we suggest a significant role of export-platform FDI into Poland, while the importance of FDI for vertical integration is limited suggesting that the sourcing of intermediate goods from Poland primarily occurs through arm's-length contractual outsourcing...... instead of in-house sourcing of multinational enterprises. The paper also suggests that over the sample period, where Poland has evolved into a relatively stable economic environment, the role of export-platform FDI has increased significantly.  ...

  2. Platform for Action Guides Chinese Women

    Institute of Scientific and Technical Information of China (English)

    1996-01-01

    THE intense excitement of the United Nations Fourth World Conference on Women (FWCW) waned, with Chinese women realizing the heavy commitments outlined in the Beijing Declaration and the Platform for Action. The documents, which represent the grand goals women have set for realizing their emancipation, will surely be fulfilled through the arduous efforts of women throughout the world. A look back at the past year following the release of the Platform for Action reveals the earnest and effective efforts Chinese women have made for realizing

  3. Traffic information computing platform for big data

    Energy Technology Data Exchange (ETDEWEB)

    Duan, Zongtao, E-mail: ztduan@chd.edu.cn; Li, Ying, E-mail: ztduan@chd.edu.cn; Zheng, Xibin, E-mail: ztduan@chd.edu.cn; Liu, Yan, E-mail: ztduan@chd.edu.cn; Dai, Jiting, E-mail: ztduan@chd.edu.cn; Kang, Jun, E-mail: ztduan@chd.edu.cn [Chang' an University School of Information Engineering, Xi' an, China and Shaanxi Engineering and Technical Research Center for Road and Traffic Detection, Xi' an (China)

    2014-10-06

    Big data environment create data conditions for improving the quality of traffic information service. The target of this article is to construct a traffic information computing platform for big data environment. Through in-depth analysis the connotation and technology characteristics of big data and traffic information service, a distributed traffic atomic information computing platform architecture is proposed. Under the big data environment, this type of traffic atomic information computing architecture helps to guarantee the traffic safety and efficient operation, more intelligent and personalized traffic information service can be used for the traffic information users.

  4. Reconcile: A Coreference Resolution Research Platform

    Energy Technology Data Exchange (ETDEWEB)

    Stoyanov, V; Cardie, C; Gilbert, N; Riloff, E; Buttler, D; Hysom, D

    2009-10-29

    Despite the availability of standard data sets and metrics, approaches to the problem of noun phrase coreference resolution are hard to compare empirically due to the different evaluation setting stemming, in part, from the lack of comprehensive coreference resolution research platforms. In this tech report we present Reconcile, a coreference resolution research platform that aims to facilitate the implementation of new approaches to coreference resolution as well as the comparison of existing approaches. We discuss Reconcile's architecture and give results of running Reconcile on six data sets using four evaluation metrics, showing that Reconcile's performance is comparable to state-of-the-art systems in coreference resolution.

  5. Reducing Resistance

    DEFF Research Database (Denmark)

    Lindell, Johanna

    care may influence decisions on antibiotic use. Based on video-and audio recordings of physician-patient consultations it is investigated how treatment recommendations are presented, can be changed, are forecast and explained, and finally, how they seemingly meet resistance and how this resistance......Antibiotic resistance is a growing public health problem both nationally and internationally, and efficient strategies are needed to reduce unnecessary use. This dissertation presents four research studies, which examine how communication between general practitioners and patients in Danish primary...... is responded to.The first study in the dissertation suggests that treatment recommendations on antibiotics are often done in a way that encourages patient acceptance. In extension of this, the second study of the dissertation examines a case, where acceptance of such a recommendation is changed into a shared...

  6. Anticoagulant Resistance

    DEFF Research Database (Denmark)

    Heiberg, Ann-Charlotte

    Although sewer rat control is carried out in more than 80 % of all Danish municipalities, with usage of large amounts of anticoagulant rodenticides, knowledge on anticoagulant resistance among rats living in the sewers is limited. As rat problems in urban areas are believed to be related to sewer...... problems (70-90 % in UK and DK) unawareness of resistance amongst these populations of Brown rats may constitute a future control problem and knowledge on this issue has become crucial. Rats were captured in sewers from seven different locations in the suburban area of Copenhagen. Locations was chosen...... to represent different sewer rat management strategies i) no anticoagulants for approx. 20 years ii) no anticoagulants for the last 5 years and iii) continuous control for many years. Animals were tested for resistance to bromadiolone by Blood-Clotting Response test, as bromadiolone is the most frequently used...

  7. Androgen resistance.

    Science.gov (United States)

    Hughes, Ieuan A; Deeb, Asma

    2006-12-01

    Androgen resistance causes the androgen insensitivity syndrome in its variant forms and is a paradigm of clinical syndromes associated with hormone resistance. In its complete form, the syndrome causes XY sex reversal and a female phenotype. Partial resistance to androgens is a common cause of ambiguous genitalia of the newborn, but a similar phenotype may result from several other conditions, including defects in testis determination and androgen biosynthesis. The biological actions of androgens are mediated by a single intracellular androgen receptor encoded by a gene on the long arm of the X chromosome. Mutations in this gene result in varying degrees of androgen receptor dysfunction and phenotypes that often show poor concordance with the genotype. Functional characterization and three-dimensional modelling of novel mutant receptors has been informative in understanding the mechanism of androgen action. Management issues in syndromes of androgen insensitivity include decisions on sex assignment, timing of gonadectomy in relation to tumour risk, and genetic and psychological counselling.

  8. Three-dimensional finite element analysis of platform switched implant

    Science.gov (United States)

    2017-01-01

    PURPOSE The purpose of this study was to analyze the influence of the platform switching concept on an implant system and peri-implant bone using three-dimensional finite element analysis. MATERIALS AND METHODS Two three-dimensional finite element models for wide platform and platform switching were created. In the wide platform model, a wide platform abutment was connected to a wide platform implant. In the platform switching model, the wide platform abutment of the wide platform model was replaced by a regular platform abutment. A contact condition was set between the implant components. A vertical load of 300 N was applied to the crown. The maximum von Mises stress values and displacements of the two models were compared to analyze the biomechanical behavior of the models. RESULTS In the two models, the stress was mainly concentrated at the bottom of the abutment and the top surface of the implant in both models. However, the von Mises stress values were much higher in the platform switching model in most of the components, except for the bone. The highest von Mises values and stress distribution pattern of the bone were similar in the two models. The components of the platform switching model showed greater displacement than those of the wide platform model. CONCLUSION Due to the stress concentration generated in the implant and the prosthodontic components of the platform switched implant, the mechanical complications might occur when platform switching concept is used. PMID:28243389

  9. City-as-a-Platform: The Rise of Participatory Innovation Platforms in Finnish Cities

    Directory of Open Access Journals (Sweden)

    Ari-Veikko Anttiroiko

    2016-09-01

    Full Text Available This article discusses the idea of city as a platform. The analysis focuses on the forms and implications of citizen involvement in publicly-supported participatory innovation platforms that facilitate urban economic development in the welfare society context. The discussion opens with a review of the smart city discourse, which in the context of economic development policy translates into cities’ need to support innovativeness by creating smart environments. Participatory innovation platform is a prime example of such an environment. The empirical section discusses three cases, those of the Finnish cities of Helsinki, Tampere, and Oulu. The analysis shows that platformization in the first half of the 2010s became a strategic focal area supported by national and EU programs. Platforms are used to support both urban revitalization and economic development, of which the former is based on representative and the latter on instrumental modes of participation. Platforms are well integrated with city governments, even though they vary greatly in terms of organizational forms and scopes. Democratic culture, welfarism, and redistributive policy provide contextual support for platformization by strengthening social inclusion, taming the growth machine, and easing the tensions between pro-growth and anti-growth coalitions.

  10. Drug resistance

    NARCIS (Netherlands)

    Gorter, J.A.; Potschka, H.; Noebels, J.L.; Avoli, M.; Rogawski, M.A.; Olsen, R.W.; Delgado-Escueta, A.V.

    2012-01-01

    Drug resistance remains to be one of the major challenges in epilepsy therapy. Identification of factors that contribute to therapeutic failure is crucial for future development of novel therapeutic strategies for difficult-to-treat epilepsies. Several clinical studies have shown that high seizure f

  11. Learning Management Platform for CyberCIEGE

    Science.gov (United States)

    2011-12-01

    Generate Report Function .......................................27 Figure 16. Input and Output Selector Dialog Window...CLE is a platform that allows academic and research collaboration and it is built on open pedagogy and open standard [16]. In those situations...output files, as shown in Figure 16. 28 Figure 16. Input and Output Selector Dialog Window This dialog selects two input mapping files and

  12. JBoss Weld CDI for Java platform

    CERN Document Server

    Finnegan, Ken

    2013-01-01

    This book is a mini tutorial with plenty of code examples and strategies to give you numerous options when building your own applications.""JBoss Weld CDI for Java Platform"" is written for developers who are new to dependency injection. A rudimentary knowledge of Java is required.

  13. International Clinical Trials Registry Platform (ICTRP)

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    @@ Introduction The mission of the WHO Intemational Clinical Trials Registry Platform is to ensure that a complete view of research is accessible to all those involved in health care decision making.This will improve research transparency and will ultimately strengthen tha validity and value of the scientific evidence base.The registration of all interventional trials is a scientific, ethical and moral responsibility.

  14. Cross-platform wireless sensor network development

    DEFF Research Database (Denmark)

    Hansen, Morten Tranberg; Kusy, Branislav

    -source development environment that takes a holistic approach to implementing sensor network applications. Users build applications using a drag-and-drop visual programming language Open Blocks, a language that Google selected for its App Inventor for Android. Tinylnventor uses cross-platform programming concepts...

  15. Rapid Prototyping Platform for Robotics Applications

    Science.gov (United States)

    Hwang, Kao-Shing; Hsiao, Wen-Hsu; Shing, Gaung-Ting; Chen, Kim-Joan

    2011-01-01

    For the past several years, a team in the Department of Electrical Engineering (EE), National Chung Cheng University, Taiwan, has been establishing a pedagogical approach to embody embedded systems in the context of robotics. To alleviate the burden on students in the robotics curriculum in their junior and senior years, a training platform on…

  16. A Platform for Learning Internet of Things

    Science.gov (United States)

    Bogdanovic, Zorica; Simic, Konstantin; Milutinovic, Miloš; Radenkovic, Božidar; Despotovic-Zrakic, Marijana

    2014-01-01

    This paper presents a model for conducting Internet of Things (IoT) classes based on a web-service oriented cloud platform. The goal of the designed model is to provide university students with knowledge about IoT concepts, possibilities, and business models, and allow them to develop basic system prototypes using general-purpose microdevices and…

  17. 2009 Thermochemical Conversion Platform Review Report

    Energy Technology Data Exchange (ETDEWEB)

    Ferrell, John [Office of Energy Efficiency and Renewable Energy (EERE), Washington, DC (United States)

    2009-12-01

    This document summarizes the recommendations and evaluations provided by an independent external panel of experts at the U.S. Department of Energy Biomass Program’s Thermochemical Conversion platform review meeting, held on April 14-16, 2009, at the Sheraton Denver Downtown, Denver, Colorado.

  18. Mobile platform for acoustic mine detection applications

    Science.gov (United States)

    Libbey, Brad; Fenneman, Douglas; Burns, Brian

    2005-06-01

    Researchers in academia have successfully demonstrated acoustic landmine detection techniques. These typically employ acoustic or seismic sources to induce vibration in the mine/soil system, and use vibration sensors such as laser vibrometers or geophones to measure the resultant surface motion. These techniques exploit the unique mechanical properties of landmines to discriminate the vibration response of a buried mine from an off-target measurement. The Army requires the ability to rapidly and reliably scan an area for landmines and is developing a mobile platform at NVESD to meet this requirement. The platform represents an initial step toward the implementation of acoustic mine detection technology on a representative field vehicle. The effort relies heavily on the acoustic mine detection cart system developed by researchers at the University of Mississippi and Planning Systems, Inc. The NVESD platform consists of a John Deere E-gator configured with a robotic control system to accurately position the vehicle. In its present design, the E-gator has been outfitted with an array of laser vibrometers and a bank of loudspeakers. Care has been taken to ensure that the vehicle"s mounting hardware and data acquisition algorithms are sufficiently robust to accommodate the implementation of other sensor modalities. A thorough discussion of the mobile platform from its inception to its present configuration will be provided. Specific topics to be addressed include the vehicle"s control and data acquisition systems. Preliminary results from acoustic mine detection experiments will also be presented.

  19. Collapse of modern carbonate platform margins

    Energy Technology Data Exchange (ETDEWEB)

    Mullins, H.T.; Hine, A.C.; Gardulski, A.

    1985-01-01

    Modern carbonate platform margins in the Florida-Bahama region have been viewed as depositional or constructional features. However, recent studies have shown that carbonate escarpments, such as the Blake-Bahama and West Florida Escarpments, are erosional in origin where the platform margins have a scalloped or horse-shoe shape. Seismic reflection data from one of these crescentic features along the west Florida platform margin indicate that it originated by large scale gravity collapse (slump). This collapse structure extends for at least 120 km along the margin and has removed about 350 m of strata as young as early Neogene. Although at least three generations of slope failure are recognized, catastrophic collapse appears to have occurred in the mid-Miocene. Gravitational instability due to high rates of sediment accumulation may have been the triggering mechanism. These data suggest that submarine slumping is an important process in the retreat of limestone escarpments and in the generation of carbonate megabreccia debris flows. Scalloped platform margins occur on satellite images of northern Exuma Sound and Columbus Basin in the Bahamas. The authors suggest that large-scale submarine slumping can cause elongation of structurally controlled intraplatform basins (Exuma South), and produce anomalous horse-shoe shaped basins (Columbus Basin) by mega-collapse processes.

  20. Platform Technology for Developing Purification Processes

    NARCIS (Netherlands)

    Eppink, M.H.M.; Schreurs, R.; Gijsen, A.; Verhoeven, K.

    2009-01-01

    To shorten time to market for new therapeutic proteins, new and fast methods, such as high throughput screening, are needed to speed up downstream processing. The platform technology discussed in this article includes a structural approach that can be used as a general procedure to purify therapeuti

  1. FDI as an Export-Platform

    DEFF Research Database (Denmark)

    Hajderllari, Luljeta; Karantininis, Konstantinos; Lawson, Lartey Godwin

    towards countries with large exports of agri-food, thereby supporting the hypothesis that FDI is used as an export-platform. FDI is coupled with high exports from Denmark, probably of raw or semi-processed food products for further processing and exports. We also find that FDI is higher in countries...

  2. Designing Polymeric Microfluidic Platforms for Biomedical Applications

    DEFF Research Database (Denmark)

    Vedarethinam, Indumathi

    Micro- and Nanotechnology have the potential to offer a smart solution for diagnostics and academia research with rapid, low cost, robust analysis systems to facilitate biological analyses. New, high throughput microfluidic platforms have the potential to surpass in performance the conventional a...

  3. On designing a pervasive mobile learning platform

    Directory of Open Access Journals (Sweden)

    Teemu H. Laine

    2010-12-01

    Full Text Available This article presents the features, design and architecture of the Myst pervasive game platform that has been applied in creating pervasive mobile learning games in various contexts such as science festivals and museums in Finland. Based on our experiences with the development, we draw a set of design principles for creating successfully a pervasive game platform that can be easily ported to various contexts. These principles advocate openness, flexibility, interaction models, connections to the outside world, and participatory design of the game content. In the evaluation part we present preliminary results of tests conducted in Finland at the SciFest 2008 festival in Joensuu and at the Museum of Technology in Helsinki. The results suggest that games built with the Myst platform are particularly suitable for children and young adults, and these games motivate players to interact with the environment and help to learn by discovering new things. The Myst platform has clearly potential for similar success in other environments due to easy portability and extensibility.

  4. A gimbal platform stabilization for topographic applications

    Energy Technology Data Exchange (ETDEWEB)

    Michele, Mangiameli, E-mail: michele.mangiameli@dica.unict.it; Giuseppe, Mussumeci [Dept. of Civil Engineering and Architecture, University of Catania, Catania (Italy)

    2015-03-10

    The aim of this work is the stabilization of a Gimbal platform for optical sensors acquisitions in topographic applications using mobile vehicles. The stabilization of the line of sight (LOS) consists in tracking the command velocity in presence of nonlinear noise due to the external environment. The hardware architecture is characterized by an Ardupilot platform that allows the control of both the mobile device and the Gimbal. Here we developed a new approach to stabilize the Gimbal platform, which is based on neural network. For the control system, we considered a plant that represents the transfer function of the servo system control model for an inertial stabilized Gimbal platform. The transductor used in the feed-back line control is characterized by the Rate Gyro transfer function installed onboard of Ardupilot. For the simulation and investigation of the system performance, we used the Simulink tool of Matlab. Results show that the hardware/software approach is efficient, reliable and cheap for direct photogrammetry, as well as for general purpose applications using mobile vehicles.

  5. PROBA-V Mission Exploitation Platform

    Directory of Open Access Journals (Sweden)

    Erwin Goor

    2016-07-01

    Full Text Available As an extension of the PROBA-Vegetation (PROBA-V user segment, the European Space Agency (ESA, de Vlaamse Instelling voor Technologisch Onderzoek (VITO, and partners TRASYS and Spacebel developed an operational Mission Exploitation Platform (MEP to drastically improve the exploitation of the PROBA-V Earth Observation (EO data archive, the archive from the historical SPOT-VEGETATION mission, and derived products by researchers, service providers, and thematic users. The analysis of the time series of data (petabyte range is addressed, as well as the large scale on-demand processing of the complete archive, including near real-time data. The platform consists of a private cloud environment, a Hadoop-based processing environment and a data manager. Several applications are released to the users, e.g., a full resolution viewing service, a time series viewer, pre-defined on-demand processing chains, and virtual machines with powerful tools and access to the data. After an initial release in January 2016 a research platform was deployed gradually, allowing users to design, debug, and test applications on the platform. From the PROBA-V MEP, access to, e.g., Sentinel-2 and Sentinel-3 data will be addressed as well.

  6. Multipurpose Platform for Electronic Currency System

    Directory of Open Access Journals (Sweden)

    Andreea Magdalena Dae

    2014-12-01

    Full Text Available Nowadays, there are multiple solutions for exchanging electronic currencies which will most probably replace physical money. This paper presents a platform for electronic currency system implemented within a Java smart card for accessing different types of products or services. The user interacts with an “electronic currency bank” and with a merchant through a secure protocol.

  7. Xamarin cross-platform application development

    CERN Document Server

    Peppers, Jonathan

    2015-01-01

    If you are a developer with experience in C# and are just getting into mobile development, this is the book for you. If you have experience with desktop applications or the Web, this book will give you a head start on cross-platform development.

  8. Estimation of Errors in Force Platform Data

    Science.gov (United States)

    Psycharakis, Stelios G.; Miller, Stuart

    2006-01-01

    Force platforms (FPs) are regularly used in the biomechanical analysis of sport and exercise techniques, often in combination with image-based motion analysis. Force time data, particularly when combined with joint positions and segmental inertia parameters, can be used to evaluate the effectiveness of a wide range of movement patterns in sport…

  9. Rapid world modelling from a mobile platform

    Energy Technology Data Exchange (ETDEWEB)

    Barry, R.E.; Jones, J.P. [Oak Ridge National Lab., TN (United States); Little, C.Q. [Sandia National Labs., Albuquerque, NM (United States); Wilson, C.W.

    1997-04-01

    The ability to successfully use and interact with a computerized world model is dependent on the ability to create an accurate world model. The goal of this project was to develop a prototype system to remotely deploy sensors into a workspace, collect surface information, and rapidly build an accurate world model of that workspace. A key consideration was that the workspace areas are typically hazardous environments, where it is difficult or impossible for humans to enter. Therefore, the system needed to be fully remote, with no external connections. To accomplish this goal, an electric, mobile platform with battery power sufficient for both the platform and sensor electronics was procured and 3D range sensors were deployed on the platform to capture surface data within the workspace. A radio Ethernet connection was used to provide communications to the vehicle and all on-board electronics. Video from on-board cameras was also transmitted to the base station and used to teleoperate the vehicle. Range data generated by the on-board 3D sensors was transformed into surface maps, or models. Registering the sensor location to a consistent reference frame as the platform moved through the workspace allowed construction of a detailed 3D world model of the extended workspace.

  10. Verkeer in het Platform Integrale Energieanalyse (PIE)

    NARCIS (Netherlands)

    Brink RMM van den; Feimann PFL; LAE

    2003-01-01

    Dit rapport beschrijft het deelmodel Verkeer en Vervoer (PIE-VeV) van het Platform voor Integrale Energie- en emissieverkenningen (PIE). PIE is door de doelgroep Energie ontwikkeld in nauwe samenwerking met het ECN en is een integratieplatform dat de grootte en de samenstelling van de vraag naar

  11. Using the MVC architecture on . NET platform

    OpenAIRE

    Ježek, David

    2011-01-01

    This thesis deals with usage of MVC (Model View Controller) technology in web development on ASP.NET platform from Microsoft. Mainly it deals with latest version of framework ASP.NET MVC 3. First part describes MVC architecture and the second describes usage of MVC in certain parts of web application an comparing with PHP.

  12. Simultanuous Location and Mapping - A Simulation Platform

    DEFF Research Database (Denmark)

    Sejerøe, Thomas Hanefeld; Ravn, Ole; Poulsen, Niels Kjølstad

    2005-01-01

    In this paper we present a simulation platform for evaluate methods for simultaneous location and mapping. The platfor is based on The KALMTOOL 2 toolbox which is a set of MATLAB tools for state estimation for nonlinear systems. The toolbox contains functions for extended Kalman filtering as well...

  13. Building National Innovation Platform in China

    DEFF Research Database (Denmark)

    Li, Jizhen; Deng, Quwen; Sørensen, Olav Jull

    2011-01-01

    The focus of the article is the "national innovation platform" that are being build in China to enhance interaction between stakeholders and encourage knowledge flows. The textile industry is used as an example to discuss suitablity and lay a foundation for theoretical reflections of the new...

  14. Simulation Platform for Vision Aided Inertial Navigation

    Science.gov (United States)

    2014-09-18

    canyons, indoors or underground. It is also possible for a GPS signal to be jammed. This weakness motivates the development of alternate navigation ...Johnson, E. N., Magree, D., Wu, A., & Shein, A. (2013). "GPS‐Denied Indoor and Outdoor Monocular Vision Aided Navigation and Control of Unmanned...SIMULATION PLATFORM FOR VISION AIDED INERTIAL NAVIGATION THESIS SEPTEMBER 2014 Jason Gek

  15. 2009 Biochemical Conversion Platform Review Report

    Energy Technology Data Exchange (ETDEWEB)

    Ferrell, John [Office of Energy Efficiency and Renewable Energy (EERE), Washington, DC (United States)

    2009-12-01

    This document summarizes the recommendations and evaluations provided by an independent external panel of experts at the U.S. Department of Energy Biomass Program’s Biochemical Conversion platform review meeting, held on April 14-16, 2009, at the Sheraton Denver Downtown, Denver, Colorado.

  16. 2009 Integrated Biorefinery Platform Review Report

    Energy Technology Data Exchange (ETDEWEB)

    Ferrell, John [Office of Energy Efficiency and Renewable Energy (EERE), Washington, DC (United States)

    2009-12-01

    This document summarizes the recommendations and evaluations provided by an independent external panel of experts at the U.S. Department of Energy Biomass Program‘s Integrated Biorefinery (IBR) platform review meeting, held on February 18–19, 2009, at the Westin National Harbor, National Harbor, Maryland.

  17. Cross-platform wireless sensor network development

    DEFF Research Database (Denmark)

    Hansen, Morten Tranberg; Kusy, Branislav

    -source development environment that takes a holistic approach to implementing sensor network applications. Users build applications using a drag-and-drop visual programming language Open Blocks, a language that Google selected for its App Inventor for Android. Tinylnventor uses cross-platform programming concepts...

  18. Platform Precision Autopilot Overview and Mission Performance

    Science.gov (United States)

    Strovers, Brian K.; Lee, James A.

    2009-01-01

    The Platform Precision Autopilot is an instrument landing system-interfaced autopilot system, developed to enable an aircraft to repeatedly fly nearly the same trajectory hours, days, or weeks later. The Platform Precision Autopilot uses a novel design to interface with a NASA Gulfstream III jet by imitating the output of an instrument landing system approach. This technique minimizes, as much as possible, modifications to the baseline Gulfstream III jet and retains the safety features of the aircraft autopilot. The Platform Precision Autopilot requirement is to fly within a 5-m (16.4-ft) radius tube for distances to 200 km (108 nmi) in the presence of light turbulence for at least 90 percent of the time. This capability allows precise repeat-pass interferometry for the Unmanned Aerial Vehicle Synthetic Aperture Radar program, whose primary objective is to develop a miniaturized, polarimetric, L-band synthetic aperture radar. Precise navigation is achieved using an accurate differential global positioning system developed by the Jet Propulsion Laboratory. Flight-testing has demonstrated the ability of the Platform Precision Autopilot to control the aircraft within the specified tolerance greater than 90 percent of the time in the presence of aircraft system noise and nonlinearities, constant pilot throttle adjustments, and light turbulence.

  19. Building National Innovation Platform in China

    DEFF Research Database (Denmark)

    Li, Jizhen; Deng, Quwen; Sørensen, Olav Jull

    2011-01-01

    The focus of the article is the "national innovation platform" that are being build in China to enhance interaction between stakeholders and encourage knowledge flows. The textile industry is used as an example to discuss suitablity and lay a foundation for theoretical reflections of the new...

  20. Development of Industrial Yeast Platform Strains

    DEFF Research Database (Denmark)

    Bergdahl, Basti; Dato, Laura; Förster, Jochen

    2014-01-01

    frequently encounter high substrate concentrations, low pH, high temperatures and various inhibitory compounds originating either from the raw material used or from cellular metabolism. The aim of this research project is to develop robust platform strains of Saccharomyces cerevisiae based on industrial...

  1. Towards a Market Entry Framework for Digital Payment Platforms

    DEFF Research Database (Denmark)

    Kazan, Erol; Damsgaard, Jan

    2016-01-01

    This study presents a framework to understand and explain the design and configuration of digital payment platforms and how these platforms create conditions for market entries. By embracing the theoretical lens of platform envelopment, we employed a multiple and comparative-case study...... in a European setting by using our framework as an analytical lens to assess market-entry conditions. We found that digital payment platforms have acquired market entry capabilities, which is achieved through strategic platform design (i.e., platform development and service distribution) and technology design...... (i.e., issuing evolutionary and revolutionary payment instruments). The studied cases reveal that digital platforms leverage payment services as a mean to bridge and converge core and adjacent platform markets. In so doing, platform envelopment strengthens firms’ market position in their respective...

  2. Turbine blade and non-integral platform with pin attachment

    Energy Technology Data Exchange (ETDEWEB)

    Campbell, Christian Xavier; Eng, Darryl; Marra, John J.

    2016-08-02

    Platforms (36, 38) span between turbine blades (23, 24, 25) on a disk (32). Each platform may be individually mounted to the disk by a pin attachment (42). Each platform (36) may have a rotationally rearward edge portion (50) that underlies a forward portion (45) of the adjacent platform (38). This limits centrifugal bending of the rearward portion of the platform, and provides coolant sealing. The rotationally forward edge (44A, 44B) of the platform overlies a seal element (51) on the pressure side (28) of the forwardly adjacent blade, and does not underlie a shelf on that blade. The pin attachment allows radial mounting of each platform onto the disk via tilting (60) of the platform during mounting to provide mounting clearance for the rotationally rearward edge portion (50). This facilitates quick platform replacement without blade removal.

  3. Towards a Market Entry Framework for Digital Payment Platforms

    DEFF Research Database (Denmark)

    Kazan, Erol; Damsgaard, Jan

    2016-01-01

    (i.e., issuing evolutionary and revolutionary payment instruments). The studied cases reveal that digital platforms leverage payment services as a mean to bridge and converge core and adjacent platform markets. In so doing, platform envelopment strengthens firms’ market position in their respective......This study presents a framework to understand and explain the design and configuration of digital payment platforms and how these platforms create conditions for market entries. By embracing the theoretical lens of platform envelopment, we employed a multiple and comparative-case study...... in a European setting by using our framework as an analytical lens to assess market-entry conditions. We found that digital payment platforms have acquired market entry capabilities, which is achieved through strategic platform design (i.e., platform development and service distribution) and technology design...

  4. A Comparative Study on Hardware Platforms for Wireless Sensor Networks

    Directory of Open Access Journals (Sweden)

    Thang Vu Chien

    2012-01-01

    Full Text Available Recently, Wireless Sensor Networks (WSNs attract a great deal of research attention, and are envisioned to support a variety of applications, including building monitoring, environment control, wild-life habitat monitoring, forest fire detection, industry automation, military, security, and health-care. Over the years, we have seen a variety of hardware platforms for WSNs to facilitate developing WSN applications. In this paper, we provide a comprehensive review of existing hardware platforms for WSNs. We first present the hardware architecture of a wireless sensor node. We then survey the major hardware platforms for WSNs and present a comparison of these hardware platforms. Finally we present some recommendations from the perspectives of hardware platform developers and hardware platform users. The authors hope that making information about existing hardware platforms will assist researchers working in this area to appreciate the diversity of platforms available to them and to help them select the most appropriate platform for their purposes.

  5. Turbine blade and non-integral platform with pin attachment

    Science.gov (United States)

    Campbell, Christian X; Eng, Darryl; Marra, John J

    2015-01-27

    Platforms (36, 38) span between turbine blades (23, 24, 25) on a disk (32). Each platform may be individually mounted to the disk by a pin attachment (42). Each platform (36) may have a rotationally rearward edge portion (50) that underlies a forward portion (45) of the adjacent platform (38). This limits centrifugal bending of the rearward portion of the platform, and provides coolant sealing. The rotationally forward edge (44A, 44B) of the platform overlies a seal element (51) on the pressure side (28) of the forwardly adjacent blade, and does not underlie a shelf on that blade. The pin attachment allows radial mounting of each platform onto the disk via tilting (60) of the platform during mounting to provide mounting clearance for the rotationally rearward edge portion (50). This facilitates quick platform replacement without blade removal.

  6. Anthelmintic resistance.

    Science.gov (United States)

    Waller, P J

    1997-11-01

    Since the first reports of resistance to the broad spectrum anthelmintics were made some three decades ago, this phenomenon has changed from being considered merely as a parasitological curiosity to a state of industry crisis in certain livestock sectors. This extreme situation exists with the small ruminant industry of the tropical/sub-tropical region of southern Latin America where resistance to the entire broad spectrum anthelmintic arsenal now occurs. In contrast, the cattle industry does not appear to be threatened--or so it seems. Although field reports of resistance have been made to the range of broad spectrum anthelmintics in nematode parasites of cattle, it appears that the evolution of resistance in cattle parasites is not as dramatic as for sheep worms. However, one cannot remain confident that this state of affairs will remain static. Concern is shared amongst parasitologists that we have not looked closely enough. In regions of the world where internal parasites are considered a problem in cattle and drenching occurs frequently, no widespread surveys have been carried out. It appears that because of the very high costs and risks associated with taking a new active drug down the development track to marketing, that the pharmaceutical industry has, in general, turned away from this activity. By implication, the international small ruminant industry is too small for these companies to make the necessary investment. This begs two questions: What is the fate of the sheep (and goat) industries in those parts of the world where resistance is rampant and immediate ameliorative parasite control options are required? What will be the response if significant resistance is found in cattle parasites? There is a body of opinion which suggests that if resistance becomes an issue in the control of cattle parasites then the pharmaceutical industry will find it commercially attractive to re-enter the anthelmintic discovery and development business. This is based on the

  7. Cross-platform learning: on the nature of children's learning from multiple media platforms.

    Science.gov (United States)

    Fisch, Shalom M

    2013-01-01

    It is increasingly common for an educational media project to span several media platforms (e.g., TV, Web, hands-on materials), assuming that the benefits of learning from multiple media extend beyond those gained from one medium alone. Yet research typically has investigated learning from a single medium in isolation. This paper reviews several recent studies to explore cross-platform learning (i.e., learning from combined use of multiple media platforms) and how such learning compares to learning from one medium. The paper discusses unique benefits of cross-platform learning, a theoretical mechanism to explain how these benefits might arise, and questions for future research in this emerging field.

  8. Comparisons of the suture zones along a geotraverse from the Scythian Platform to the Arabian Platform

    Directory of Open Access Journals (Sweden)

    Ali Yılmaz

    2014-11-01

    Full Text Available The area from the Greater Caucasus to the southeast Turkey is characterized and shaped by several major continental blocks. These are Scythian Platform, Pontian–Transcaucasus Continent-Arc System (PTCAS, the Anatolian–Iranian and the Arabian Platforms. The aim of this paper is to define these continental blocks and describe and also compare their boundary relationships along the suture zones. The Scythian Platform displays the evidence of the Hercynian and Alpine orogens. This platform is separated from the PTCAS by the Greater Caucasus Suture Zone. The incipient collision began along this suture zone before middle–late Carboniferous whereas the final collision occurred before Oligocene. The PTCAS can be divided into four structural units: (1 the Georgian Block – northern part of the Pontian–Transcaucasian island-arc, (2 the southern and eastern Black Sea Coast–Adjara–Trialeti Unit, (3 the Artvin–Bolnisi Unit, comprising the northern part of the southern Transcaucasus, and (4 the Imbricated Bayburt–Garabagh Unit. The PTCAS could be separated from the Anatolian–Iranian Platform by the North Anatolian–Lesser Caucasus Suture (NALCS zone. The initial collision was developed in this suture zone during Senonian–early Eocene and final collision before middle Eocene or Oligocene–Miocene. The Anatolian–Iranian Platform (AIP is made up of the Tauride Platform and its metamorphic equivalents together with Iranian Platform. It could be separated from the Arabian Platform by the Southeastern Anatolian Suture (SEAS zone. The collision ended before late Miocene along this suture zone. The southernmost continental block of the geotraverse is the Arabian Platform, which constitutes the northern part of the Arabian–African Plate. This platform includes a sequence from the Precambrian felsic volcanic and clastic rocks to the Campanian–early Maastrichtian flyschoidal clastics. All the suture zones include MORB and SSZ

  9. Antibiotic Resistance

    DEFF Research Database (Denmark)

    Hansen, Malene Plejdrup; Hoffmann, Tammy C; McCullough, Amanda R

    2015-01-01

    Numerous opportunities are available in primary care for alleviating the crisis of increasing antibiotic resistance. Preventing patients from developing an acute respiratory infection (ARI) will obviate any need for antibiotic use downstream. Hygiene measures such as physical barriers and hand...... will greatly improve the use of antibiotics for ARIs. However, used in concert, combinations are likely to enable clinicians and health care systems to implement the strategies that will reduce antimicrobial resistance in the future....... antibiotic prescribing are a major factor in the prescribing for ARIs. Professional interventions with educational components are effective, although they have modest effects, and are expensive. GPs' perceptions - that mistakenly assume as a default that patients want antibiotics for their ARIs - are often...

  10. Resistant starches.

    Science.gov (United States)

    Jenkins, D J; Kendall, C W

    2000-03-01

    Initially, it was hoped that resistant starches (ie, starches that enter the colon) would have clear advantages in the reduction of colon cancer risk and possibly the treatment of ulcerative colitis. Recent studies have confirmed the ability of resistant starch to increase fecal bulk, to increase the molar ratio of butyrate in relation to other short-chain fatty acids, and to dilute fecal bile acids. However, reduction in fecal ammonia, phenols, and N-nitroso compounds have not been achieved. At this point the picture from the standpoint of colon cancer risk reduction is not clear. Nevertheless, there is a fraction of what has been termed resistant starch (RS1), which enters the colon and acts as slowly digested, or lente, carbohydrate. Foods in this class are low glycemic index and have been shown to reduce the risk of chronic disease. They have been associated with systemic physiologic effects such as reduced postprandial insulin levels and higher high-density lipoprotein cholesterol levels. Consumption of low glycemic index foods has been shown to be related to a reduced risk of type 2 diabetes. Type 2 diabetes has in turn been related to a higher risk of colon cancer, especially colon cancer deaths. If carbohydrate has a protective role in colon cancer prevention, it may lie in the systemic effects of low glycemic index foods. The colonic advantages of different carbohydrates, therefore, remain to be documented. However, there is reason for optimism about the possible health advantages of so-called resistant starches that are slowly digested in the small intestine.

  11. Publishing Platform for Scientific Software - Lessons Learned

    Science.gov (United States)

    Hammitzsch, Martin; Fritzsch, Bernadette; Reusser, Dominik; Brembs, Björn; Deinzer, Gernot; Loewe, Peter; Fenner, Martin; van Edig, Xenia; Bertelmann, Roland; Pampel, Heinz; Klump, Jens; Wächter, Joachim

    2015-04-01

    Scientific software has become an indispensable commodity for the production, processing and analysis of empirical data but also for modelling and simulation of complex processes. Software has a significant influence on the quality of research results. For strengthening the recognition of the academic performance of scientific software development, for increasing its visibility and for promoting the reproducibility of research results, concepts for the publication of scientific software have to be developed, tested, evaluated, and then transferred into operations. For this, the publication and citability of scientific software have to fulfil scientific criteria by means of defined processes and the use of persistent identifiers, similar to data publications. The SciForge project is addressing these challenges. Based on interviews a blueprint for a scientific software publishing platform and a systematic implementation plan has been designed. In addition, the potential of journals, software repositories and persistent identifiers have been evaluated to improve the publication and dissemination of reusable software solutions. It is important that procedures for publishing software as well as methods and tools for software engineering are reflected in the architecture of the platform, in order to improve the quality of the software and the results of research. In addition, it is necessary to work continuously on improving specific conditions that promote the adoption and sustainable utilization of scientific software publications. Among others, this would include policies for the development and publication of scientific software in the institutions but also policies for establishing the necessary competencies and skills of scientists and IT personnel. To implement the concepts developed in SciForge a combined bottom-up / top-down approach is considered that will be implemented in parallel in different scientific domains, e.g. in earth sciences, climate research and

  12. New Design Concept for a Lifting Platform Made of Composite Material

    Science.gov (United States)

    Solazzi, L.; Scalmana, R.

    2013-08-01

    Elevating work platforms are hoists equipment that are increasingly used in many applications, like in the construction industry and in the maintenance field. The maintenance of the hub of the wind turbines, for example, can be done through the use of a working platform; these structures have to reach great heights and obviously they have to satisfy the constraints induced by the highway standards, like the maximum axle load and the maximum overall dimensions. To satisfy these requests the material of the structures changed from the classic structural steel (S235 JR, S275 JR or S355JR) to high strength steel (S700 to S1100 or more), characterized by a significantly higher specific resistance. The idea of this paper is to use a composite material for the construction of the arms of an elevating platform in order to reduce the global weight of the machine. The analyses on the new kind of platform show the technical possibility to change the material of the arms with composite materials and this produces a significant reduction of the weight of the machine components, about 50 %. Being a feasibility study, still remain open some problems such as the mechanical behavior of the used composite materials (fatigue, environment effects, etc.).

  13. Social network of PESCA (Open Source Platform for eHealth).

    Science.gov (United States)

    Sanchez, Carlos L; Romero-Cuevas, Miguel; Lopez, Diego M; Lorca, Julio; Alcazar, Francisco J; Ruiz, Sergio; Mercado, Carmen; Garcia-Fortea, Pedro

    2008-01-01

    Information and Communication Technologies (ICTs) are revolutionizing how healthcare systems deliver top-quality care to citizens. In this way, Open Source Software (OSS) has demonstrated to be an important strategy to spread ICTs use. Several human and technological barriers in adopting OSS for healthcare have been identified. Human barriers include user acceptance, limited support, technical skillfulness, awareness, resistance to change, etc., while Technological barriers embrace need for open standards, heterogeneous OSS developed without normalization and metrics, lack of initiatives to evaluate existing health OSS and need for quality control and functional validation. The goals of PESCA project are to create a platform of interoperable modules to evaluate, classify and validate good practices in health OSS. Furthermore, a normalization platform will provide interoperable solutions in the fields of healthcare services, health surveillance, health literature, and health education, knowledge and research. Within the platform, the first goal to achieve is the setup of the collaborative work infrastructure. The platform is being organized as a Social Network which works to evaluate five scopes of every existing open source tools for eHealth: Open Source Software, Quality, Pedagogical, Security and privacy and Internationalization/I18N. In the meantime, the knowledge collected from the networking will configure a Good Practice Repository on eHealth promoting the effective use of ICT on behalf of the citizen's health.

  14. Nonlinear ultimate strength analysis of fixed offshore platforms for earthquake environments

    Energy Technology Data Exchange (ETDEWEB)

    Chang, S.S. [Hudson Engineering Corp., Houston, TX (United States)

    1995-12-01

    The design of an offshore platform usually requires the use of ASME B31.3 and API (American Petroleum Institute) RP 2A design codes. ASME B31.3 addresses the design of pressure piping systems for offshore facilities while API RP 2A ``Recommended Practice for Planning, Designing and Constructing Fixed Offshore Platforms`` (WSD or LRFD) addresses the structural design. This paper first identifies the difference between the ASME B31.3 and API RP 2A on the earthquake load requirements. Second, the paper presents a nonlinear static pushover analysis of a typical fixed offshore platform subject to a ductility level earthquake in 394 ft (120 m) of water depth. The analysis uses a three-dimensional structural model consisting of STRUT, BEAM-COLUMN and LINEAR BEAM elements to determine the structural response while properly accounting for structure-pile-soil interaction effort. Finally, the status of current on-going efforts to implement the API RP 2A code (LRFD version) to the ISO code (International Organization for Standardization), particularly on the earthquake resistant design aspect of fixed offshore the platforms, is briefly reported.

  15. Intermittent Chemotherapy as a Platform for Testing Novel Agents in Patients With Metastatic Castration-Resistant Prostate Cancer: A Department of Defense Prostate Cancer Clinical Trials Consortium Randomized Phase II Trial of Intermittent Docetaxel With Prednisone With or Without Maintenance GM-CSF.

    Science.gov (United States)

    Aggarwal, Rahul R; Beer, Tomasz M; Weinberg, Vivian K; Higano, Celestia; Taplin, Mary-Ellen; Ryan, Charles J; Lin, Amy M; Alumkal, Joshi; Graff, Julie N; Nordquist, Luke T; Herrera, Isheen; Small, Eric J

    2015-06-01

    Immunotherapy with granulocyte-macrophage colony-stimulating factor (GM-CSF), an agent that previously demonstrated antitumor activity, was evaluated within an intermittent chemotherapy framework of docetaxel with prednisone (D+P) in metastatic castration-resistant prostate cancer (mCRPC). mCRPC patients with ≥ 50% prostate-specific antigen (PSA) decline after 6 cycles of D+P were randomized to either GM-CSF or observation (Obs). At disease progression (PD), D+P was reinitiated for 6 cycles followed by the same "off chemotherapy" regimen in patients eligible for chemotherapy interruption. The sequence was repeated until PD during chemotherapy, lack of PSA response to chemotherapy, or unacceptable toxicity. The primary end point was time to chemotherapy resistance (TTCR). Of 125 patients enrolled, 52 (42%) experienced ≥ 50% PSA decline on induction D+P and were randomized to GM-CSF (n = 27) or Obs (n = 25). The median time to PD was 3.3 months (95% confidence interval [CI], 2.4-3.5) and 1.5 months (95% CI, 1.5-2.4) during the initial course of GM-CSF and Obs, respectively. Twelve of 26 (46%) patients responded to a second course of D+P. Eleven randomized patients (21%) experienced PD during chemotherapy, precluding accurate assessment of TTCR. The remaining 41 randomized patients discontinued study for lack of PSA response to chemotherapy (n = 8), patient choice to not restart chemotherapy with PSA PD (n = 13), toxicity (n = 7), or study withdrawal (n = 13). Conducting a prospective study in mCRPC with maintenance immunotherapy within the framework of intermittent chemotherapy was feasible. The use of PSA instead of radiographic end points limited the number of evaluable patients. This study provides important insight into designing contemporary intermittent chemotherapy trials with maintenance immunotherapy in patients with advanced prostate cancer. Copyright © 2015 Elsevier Inc. All rights reserved.

  16. A platform independent communication library for distributed computing

    NARCIS (Netherlands)

    Groen, D.; Rieder, S.; Grosso, P.; de Laat, C.; Portegies Zwart, S.

    2010-01-01

    We present MPWide, a platform independent communication library for performing message passing between supercomputers. Our library couples several local MPI applications through a long distance network using, for example, optical links. The implementation is deliberately kept light-weight, platform

  17. Towards A Research Agenda on Digital Platform Disruption

    DEFF Research Database (Denmark)

    Kazan, Erol; Tan, Chee-Wee; Lim, Eric T. K.

    Digital platforms are disruptive IT artifacts, because they facilitate the quick release of innovative platform derivatives from third parties. This study endeavors to unravel the disruptive potential, caused by distinct designs and configurations of digital platforms on market environments. We...... postulate that the disruptive potential of digital platforms is determined by the degree of alignment among the business, technology and platform profiles. Furthermore, we argue that the design and configuration of the aforementioned three elements dictates the extent to which open innovation is permitted....... To shed light on the disruptive potential of digital platforms, we opted for digital payment platforms as our unit of analysis. Through interviews with experts and payment providers, we seek to gain an in-depth appreciation of how contemporary digital payment platforms are designed and configured...

  18. Towards A Research Agenda on Digital Platform Disruption

    DEFF Research Database (Denmark)

    Kazan, Erol; Tan, Chee-Wee; Lim, Eric T. K.

    Digital platforms are disruptive IT artifacts, because they facilitate the quick release of innovative platform derivatives from third parties. This study endeavors to unravel the disruptive potential, caused by distinct designs and configurations of digital platforms on market environments. We...... postulate that the disruptive potential of digital platforms is determined by the degree of alignment among the business, technology and platform profiles. Furthermore, we argue that the design and configuration of the aforementioned three elements dictates the extent to which open innovation is permitted....... To shed light on the disruptive potential of digital platforms, we opted for digital payment platforms as our unit of analysis. Through interviews with experts and payment providers, we seek to gain an in-depth appreciation of how contemporary digital payment platforms are designed and configured...

  19. Platform Based Design for Automotive Sensor Conditioning

    CERN Document Server

    Fanucci, L; Iozzi, F; Marino, C; Rocchi, A

    2011-01-01

    In this paper a general architecture suitable to interface several kinds of sensors for automotive applications is presented. A platform based design approach is pursued to improve system performance while minimizing time-to-market.. The platform is composed by an analog front-end and a digital section. The latter is based on a microcontroller core (8051 IP by Oregano) plus a set of dedicated hardware dedicated to the complex signal processing required for sensor conditioning. The microcontroller handles also the communication with external devices (as a PC) for data output and fast prototyping. A case study is presented concerning the conditioning of a Gyro yaw rate sensor for automotive applications. Measured performance results outperform current state-of-the-art commercial devices.

  20. Molecular cell death platforms and assemblies.

    Science.gov (United States)

    Mace, Peter D; Riedl, Stefan J

    2010-12-01

    Multi-cellular animals have evolved a variety of mechanisms to respond to diverse apoptotic stimuli. In general these proceed through activation of apical caspases and culminate in executioner caspase activation and cell death. Because of the breadth of possible initiators, various molecular platforms are used to trigger different apical caspases. Although some common protein domains are used to assemble the apoptosome, the PIDDosome and death receptor complexes, an array of checks-and-balances are employed to ensure appropriate activation. Notwithstanding, these pathways share the underlying principle of proximity-dependent activation and post-translational modification. Here we will describe our current structural understanding of assembly and regulation of these signaling platforms.

  1. Virtual interconnection platform initiative scoping study

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Yong [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Kou, Gefei [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Pan, Zuohong [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Liu, Yilu [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); King Jr., Thomas J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2016-01-01

    Due to security and liability concerns, the research community has limited access to realistic large-scale power grid models to test and validate new operation and control methodologies. It is also difficult for industry to evaluate the relative value of competing new tools without a common platform for comparison. This report proposes to develop a large-scale virtual power grid model that retains basic features and represents future trends of major U.S. electric interconnections. This model will include realistic power flow and dynamics information as well as a relevant geospatial distribution of assets. This model will be made widely available to the research community for various power system stability and control studies and can be used as a common platform for comparing the efficacies of various new technologies.

  2. Security issues in e-learning platforms

    Directory of Open Access Journals (Sweden)

    Defta (Ciobanu Costinela – Luminita

    2011-12-01

    Full Text Available Security is an important issue in the actual educational context where e-learning increases in popularity and increasingly more people are taking online courses. The e-learning platforms are today production systems that need to be secured. To achieve a good level of security, there are many important elements that must be taken into account: authentication, access control, data integrity, content protection, etc. Information security can be obtained using methods such as cryptography and network protocols. In this paper we will highlight some key security issues that must be taken into consideration in developing and using an e-learning platform. We will also examine some security aspects of one of the most popular open-source e-learning systems: Moodle.

  3. A Simulation Platform for Quantifying Survival Bias

    DEFF Research Database (Denmark)

    Mayeda, Elizabeth Rose; Tchetgen Tchetgen, Eric J; Power, Melinda C

    2016-01-01

    Bias due to selective mortality is a potential concern in many studies and is especially relevant in cognitive aging research because cognitive impairment strongly predicts subsequent mortality. Biased estimation of the effect of an exposure on rate of cognitive decline can occur when mortality i......-mortality situations. This simulation platform provides a flexible tool for evaluating biases in studies with high mortality, as is common in cognitive aging research.......Bias due to selective mortality is a potential concern in many studies and is especially relevant in cognitive aging research because cognitive impairment strongly predicts subsequent mortality. Biased estimation of the effect of an exposure on rate of cognitive decline can occur when mortality...... platform with which to quantify the expected bias in longitudinal studies of determinants of cognitive decline. We evaluated potential survival bias in naive analyses under several selective survival scenarios, assuming that exposure had no effect on cognitive decline for anyone in the population. Compared...

  4. Perfect discipline platform and Promote interactive development

    Directory of Open Access Journals (Sweden)

    Xiang-ming ZENG

    2014-11-01

    Full Text Available Through the questionnaire survey of Marxism’s course construction and Ideological and Political Theory Course in 45 universities, the paper tries to discuss how to enhance the effectiveness of ideological and political theory course by platform of Marxism’s course construction. Research shows that it can enhance the effectiveness of Ideological and Political Theory Course as long as we make full use of platform construction of Marxism’s course, fully display the Marxism’s spirit with the times and the latest achievements in Ideological and political theory course, and Strengthen academic ideological and Political Theory Education. We believe that it can better cultivate socialist builders to achieve the Chinese dream by playing the educational function of Ideological and Political Theory Course.

  5. Hurricane damaged fixed platforms and wellhead structures

    Energy Technology Data Exchange (ETDEWEB)

    Shuttleworth, E.P.; Frieze, P.A.

    1998-03-01

    The objective of this study was to review data on damages to offshore platforms with a view to determining their suitability for further exploitation and analysis through a preliminary assessment of trends in the data when viewed from a risk standpoint. To realise this objective, a database on hurricane and other storm related damages was generated and past design practice, particularly concerning environmental load levels, was established. Information was gathered on extreme wave heights, damages, platform details, pushover analyses and structural frame load tests. The information was obtained through: a literature survey of journals, conference proceedings, design codes and guidelines; approaches to organisations in the offshore industry with significant experience of hurricanes, storm-damaged structures and pushover analyses; and interrogation of three major databases on offshore storm and other damages - PMB, MMS and WOAD. (author)

  6. The socializing role of expatriate online platforms

    DEFF Research Database (Denmark)

    Emontspool, Julie

    2015-01-01

    This chapter discusses the role of Information and Communication Technologies (ICTs) in expatriates’ secondary socialization into new consumption environments. On the basis of the qualitative study of a question and answer platform directed at expatriates in Brussels, this chapter differentiates ...... into the consequences of those online interactions for nationalism, where digital tools may in fact reduce expatriates’ cosmopolitanism. Secondly, the study shows collaborative knowledge construction on those platforms creates new forms of market adaptation....... between market orientation and socialization practices online. It shows how processes of market simplification, market guidance and market manipulation co-exist both in expatriates’ orientation and socialization in the new consumption context. The findings of this study firstly provide insights...

  7. Towards gaze-controlled platform games

    DEFF Research Database (Denmark)

    Muñoz, Jorge; Yannakakis, Georgios N.; Mulvey, Fiona

    2011-01-01

    This paper introduces the concept of using gaze as a sole modality for fully controlling player characters of fast-paced action computer games. A user experiment is devised to collect gaze and gameplay data from subjects playing a version of the popular Super Mario Bros platform game. The initial...... analysis shows that there is a rather limited grid around Mario where the efficient player focuses her attention the most while playing the game. The useful grid as we name it, projects the amount of meaningful visual information a designer should use towards creating successful player character...... controllers with the use of artificial intelligence for a platform game like Super Mario. Information about the eyes' position on the screen and the state of the game are utilized as inputs of an artificial neural network, which is trained to approximate which keyboard action is to be performed at each game...

  8. Dynamic Analysis of Offshore Spar Platforms

    Directory of Open Access Journals (Sweden)

    A. K. Jain

    2003-04-01

    Full Text Available Offshore spar platform is a compliant offshore floating structure used for deep water applications for drilling, production, processing, storage and offloading of ocean deposits. The offshore spar platform is modelled as a rigid body with six degrees-of-freedom (DOFs, connected to the sea bed by multicomponent catenary cables which consist of a mooring line, a clump weight, and an anchor line attached to the fairlcads. The response-dependent stiffness matrix consists of three parts: (i the restoring hydrostatic force, and the stiffness due to cables. (ii nonlinear horizontal springs, and (iii nonlinear vertical springs. A unidirectional regular wave model is used for computing the incident wave kinematics by Airy's wave theory and  hydrodynamic force by Morison's equation. The response analysis is performed in timc domain using the iterative incremental Newmark's method. Numerical studies have been conducted for sea state conditions with and without coupling of DOFs.

  9. Chein loops as potential platforms for cryptosystems

    Science.gov (United States)

    Chee, Wing Loon

    2013-04-01

    The Diffie-Hellman key exchange protocol is one of the well-known examples of public key cryptography which is based on the discrete logarithm problem (DLP): given integers g, h and n, find an integer a such that ga≡h(modn). In 2000, Ko, Lee et al. generalised the Diffie-Hellman protocol by using a class of algebraic structures called braid groups as platforms. Its security lies on the conjugacy search problem (CSP): given elements g and h in a group, find an element a in the group such that a-1ga = h. In this paper, we propose another key exchange protocol by using Chein loops—a subclass of Moufang loops. We shall discuss their potential as platforms for cryptosystems and their connection with the Ko-Lee et al. protocol.

  10. Porting salinas to the windows platform.

    Energy Technology Data Exchange (ETDEWEB)

    Reese, Garth M.; Wilson, Christopher Riley

    2006-06-01

    The ASC program has enabled significant development of high end engineering applications on massively parallel machines. There is a great benefit in providing these applications on the desktop of the analysts and designers, at least insofar as the small models may be run on these platforms, thus providing a tool set that spans the application needs. This effort documents the work of porting Salinas to the WINDOWS{trademark} platform. Selection of the tools required to compile, link, test and run Salinas in this environment is discussed. Significant problems encountered along the way are listed along with an estimation of the overall cost of the port. This report may serve as a baseline for streamlining further porting activities with other ASC codes.

  11. Modeling and simulation of luminescence detection platforms.

    Science.gov (United States)

    Salama, Khaled; Eltoukhy, Helmy; Hassibi, Arjang; El-Gamal, Abbas

    2004-06-15

    Motivated by the design of an integrated CMOS-based detection platform, a simulation model for CCD and CMOS imager-based luminescence detection systems is developed. The model comprises four parts. The first portion models the process of photon flux generation from luminescence probes using ATP-based and luciferase label-based assay kinetics. An optics simulator is then used to compute the incident photon flux on the imaging plane for a given photon flux and system geometry. Subsequently, the output image is computed using a detailed imaging sensor model that accounts for photodetector spectral response, dark current, conversion gain, and various noise sources. Finally, signal processing algorithms are applied to the image to enhance detection reliability and hence increase the overall system throughput. To validate the model, simulation results are compared to experimental results obtained from a CCD-based system that was built to emulate the integrated CMOS-based platform.

  12. Novel Biochip Platform for Nucleic Acid Analysis

    Directory of Open Access Journals (Sweden)

    Juan J. Diaz-Mochon

    2012-06-01

    Full Text Available This manuscript describes the use of a novel biochip platform for the rapid analysis/identification of nucleic acids, including DNA and microRNAs, with very high specificity. This approach combines a unique dynamic chemistry approach for nucleic acid testing and analysis developed by DestiNA Genomics with the STMicroelectronics In-Check platform, which comprises two microfluidic optimized and independent PCR reaction chambers, and a sequential microarray area for nucleic acid capture and identification by fluorescence. With its compact bench-top “footprint” requiring only a single technician to operate, the biochip system promises to transform and expand routine clinical diagnostic testing and screening for genetic diseases, cancers, drug toxicology and heart disease, as well as employment in the emerging companion diagnostics market.

  13. Nordic Baltic innovation platform for Creative Industries

    DEFF Research Database (Denmark)

    Dickson, Thomas; Järvinen, Juha; Koski, Emilia

    2006-01-01

    The purpose of this project report is to explore the potential the current status of Creative Industries (CI) and design innovation programmes provide in the Nordic-Baltic area. Moreover, this report reviews the possibilities of building an innovation platform in the Nordic-Baltic region....... To illustrate the prevailing situation, this report reviews and analyses Creative Industries and design innovation systems and actors, design promotion and its actors in each country, activities and measures – around design – in each country (main research programmes, innovation transfer systems) and finally......, results achieved in each country (new knowledge created, new forms of activities etc.), in the Nordic and Baltic region, respectively. This report concludes with discussion and an idea of how the innovation platform could be built....

  14. Development of a PDXP platform on NIF

    Science.gov (United States)

    Whitley, Heather; Schneider, Marilyn; Garbett, Warren; Pino, Jesse; Shepherd, Ronnie; Brown, Colin; Castor, John; Scott, Howard; Ellison, C. Leland; Benedict, Lorin; Sio, Hong; Lahmann, Brandon; Petrasso, Richard; Graziani, Frank

    2016-10-01

    Over the past several years, we have conducted theoretical investigations of electron-ion coupling and electronic transport in plasmas. In the regime of weakly coupled plasmas, we have identified models that we believe describe the physics well, but experimental measurements are still needed to validate the models. We are developing spectroscopic experiments to study electron-ion equilibration and electron heat transport using a polar direct drive exploding pusher (PDXP) platform at the National Ignition Facility (NIF). Initial measurements are focused on characterizing the laser-target coupling, symmetry of the PDXP implosion, and overall neutron and x-ray signals. We present images from the first set of shots and make comparisons with simulations from ARES and discuss next steps in the platform development. Prepared by LLNL under Contract DE-AC52-07NA27344. LLNL-ABS-697489.

  15. Speeding up Derivative Configuration from Product Platforms

    Directory of Open Access Journals (Sweden)

    Ruben Heradio

    2014-06-01

    Full Text Available To compete in the global marketplace, manufacturers try to differentiate their products by focusing on individual customer needs. Fulfilling this goal requires that companies shift from mass production to mass customization. Under this approach, a generic architecture, named product platform, is designed to support the derivation of customized products through a configuration process that determines which components the product comprises. When a customer configures a derivative, typically not every combination of available components is valid. To guarantee that all dependencies and incompatibilities among the derivative constituent components are satisfied, automated configurators are used. Flexible product platforms provide a big number of interrelated components, and so, the configuration of all, but trivial, derivatives involves considerable effort to select which components the derivative should include. Our approach alleviates that effort by speeding up the derivative configuration using a heuristic based on the information theory concept of entropy.

  16. En Billig GPS Data Analyse Platform

    DEFF Research Database (Denmark)

    Andersen, Ove; Christiansen, Nick; Larsen, Niels T.

    2011-01-01

    Denne artikel præsenterer en komplet software platform til analyse af GPS data. Platformen er bygget udelukkende vha. open-source komponenter. De enkelte komponenter i platformen beskrives i detaljer. Fordele og ulemper ved at bruge open-source diskuteres herunder hvilke IT politiske tiltage, der...... organisationer med et digitalt vejkort og GPS data begynde at lave trafikanalyser på disse data. Det er et krav, at der er passende IT kompetencer tilstede i organisationen....

  17. The onboard control system of "Navigator" platform

    Science.gov (United States)

    Syrov, A. S.; Smirnov, V. V.; Sokolov, V. N.; Iodko, G. S.; Mischikhin, V. V.; Kosobokov, V. N.; Shatskii, M. A.; Dobrynin, D. A.

    2016-12-01

    A brief description of the design concept, structure and performance of the onboard control system (AOCS) of the "Navigator" satellite platform, on the basis of which the spacecraft "Electro-L' and "Spektr-R" are designed, is presented. The test-flight results of the AOCS attitude accuracy are given. Approaches to the further development of the onboard control equipment for advanced spacecraft are determined and presented.

  18. Self-Healing Distributed Scheduling Platform

    OpenAIRE

    Frincu M.E.; Villegas N.M.; Petcu D.; Muller H.A.; Rouvoy R.

    2011-01-01

    International audience; Distributed systems require effective mechanisms to manage the reliable provisioning of computational resources from different and distributed providers. Moreover, the dynamic environment that affects the behaviour of such systems and the complexity of these dynamics demand autonomous capabilities to ensure the behaviour of distributed scheduling platforms and to achieve business and user objectives. In this paper we propose a self-adaptive distributed scheduling platf...

  19. En Billig GPS Data Analyse Platform

    DEFF Research Database (Denmark)

    Andersen, Ove; Christiansen, Nick; Larsen, Niels T.;

    2011-01-01

    Denne artikel præsenterer en komplet software platform til analyse af GPS data. Platformen er bygget udelukkende vha. open-source komponenter. De enkelte komponenter i platformen beskrives i detaljer. Fordele og ulemper ved at bruge open-source diskuteres herunder hvilke IT politiske tiltage, der...... organisationer med et digitalt vejkort og GPS data begynde at lave trafikanalyser på disse data. Det er et krav, at der er passende IT kompetencer tilstede i organisationen....

  20. Verification of Slam Methods on Ros Platform

    OpenAIRE

    Radovan Sivý; Daniela Perudková

    2016-01-01

    The paper deals with the problem of experimental vehicle concept for 3D SLAM method based on data from Kinect device. One part of the paper describes the design, implementation and description of the physical model of the experimental vehicle. The second describes an odometry representation with a mathematical model of the Ackerman steering as well. Next describes the ROS platform, which was determined to solve complex robotic tasks. Last part of the paper contains to the evaluation of the re...

  1. Nye pladser og platforme i byen

    DEFF Research Database (Denmark)

    Andersson, Lasse

    2010-01-01

    projekter som Platform4 i Aalborg og NDSM værftet i Amsterdam samt Skateparken i Malmö stilles skarpt på det nye landskab af kreative iværksættere og kulturbrugere som har potentiale som fremtidige ’kunder’ i butikken hos de danske kulturhuse. Det kræver dog, at kulturhusene og deres medarbejdere forstår de...

  2. Progress at Standard Space Platforms Corporation

    Science.gov (United States)

    Perkins, Frederick W.

    1992-08-01

    An account is given of a simple program structure with low costs and short schedules for the space R&D community operating outside mission-oriented, government-funded programs. In addition to furnishing launch services into orbit, the program structure furnishes engineering services through its ground station, control room, and 3-year duration 'MMSB' platform. Flights may begin as little as a year after contract signature.

  3. Large Platform Autonomy in Urban Environments

    Science.gov (United States)

    2012-08-01

    low cost ESO Stereo Video module and a commercially available automotive Millimeter Wave RADAR (MMWR) module. These sensors are shown in Figure 2...SYSTEMS (RS) MINI-SYMPOSIUM AUGUST 14-16, MICHIGAN LARGE PLATFORM AUTONOMY IN URBAN ENVIRONMENTS Chip DiBerardino Edward Mottern Tracy K...NUMBER 6. AUTHOR(S) Dariusz Mikulski; N. kott; Chip DiBerardino; Edward Mottern; Tracy Van Lierop 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT

  4. Research on informational operation application of tactical loitering platform

    Science.gov (United States)

    Wang, Huanhuan; Zhang, Jun; Li, Guoshu; Song, Jinxing; Zhang, Yunhao

    2016-11-01

    The tactical loitering platform, as a multifunctional precision guided weapon, is an important part of constitution of information warfare. Using the combined propulsion system, the flying mode of platform includes supersonic cruise and subsonic loiter. With different loads, the platform is information warfare equipments with functions of region spying, communication control, electronic jamming, target tracking, accurate attack and damage assessment. Also the ability of platform can be enforced by using data link system in the informational operation.

  5. Platform for Modeling and Simulation of Photovoltaic Generation Systems

    Directory of Open Access Journals (Sweden)

    Anny A. Arroyave-Berrio

    2013-11-01

    Full Text Available A platform for modeling and simulation using Matlab is presented. The platform has four models of photovoltaic panels. It identifies the parameters of each one, for a given solar panel, based on experimental data of voltage, current and environmental conditions. Also the platform generates four blocks, for using in Matlab-Simulink and Psim simulation tools. The experimental validation of the platform was made using the PV panels of the Metropolitan Technological Institute (ITM Lab.

  6. SERS diagnostic platforms, methods and systems microarrays, biosensors and biochips

    Energy Technology Data Exchange (ETDEWEB)

    Vo-Dinh, Tuan (Knoxville, TN)

    2007-09-11

    A Raman integrated sensor system for the detection of targets including biotargets includes at least one sampling platform, at least one receptor probe disposed on the sampling platform, and an integrated circuit detector system communicably connected to the receptor. The sampling platform is preferably a Raman active surface-enhanced scattering (SERS) platform, wherein the Raman sensor is a SERS sensor. The receptors can include at least one protein receptor and at least one nucleic acid receptor.

  7. SERS diagnostic platforms, methods and systems microarrays, biosensors and biochips

    Science.gov (United States)

    Vo-Dinh, Tuan

    2007-09-11

    A Raman integrated sensor system for the detection of targets including biotargets includes at least one sampling platform, at least one receptor probe disposed on the sampling platform, and an integrated circuit detector system communicably connected to the receptor. The sampling platform is preferably a Raman active surface-enhanced scattering (SERS) platform, wherein the Raman sensor is a SERS sensor. The receptors can include at least one protein receptor and at least one nucleic acid receptor.

  8. AN ANALYSIS ON CHOOSING A PROPER ECOMMERCE PLATFORM

    OpenAIRE

    Radu Lixandroiu; Catalin Maican

    2015-01-01

    Choosing an electronic trading platform is a very important decision when opening an online store. A suitable platform must be able to meet many of the requirements as to not confuse the user. It should provide an online business operation providing tools for managing back-office of technically. There are dozens maybe hundreds of electronic ecommerce platforms available to create an online store, so the decision to choose a platform is difficult. In this article, we tried to compare 19 of the...

  9. Platform2008年用户大全

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    2008年10月14,Platform 2008年用户大会在京举行.Platform 公司此间宣布将向市场推出多款析产品,包括LSF.X系列、系统管理软件Platform (Scali) manager、并行运算支持库Platform(Scali) MPI、网络技术软件EGO以及云技术软件VMO等.

  10. Source ATO - Large Platform Autonomy in Urban Environments

    Science.gov (United States)

    2012-08-06

    Platform Demonstrator (APD) GPS/INS Navigation System Automotive Radar Platform and Autonomy System - T2 6 August 2012 7 Navigation Unit RR N...SOURCE ATO - Large Platform Autonomy in Urban Environments N. Joseph Kott (TARDEC) Dariusz Mikulski (TARDEC) Chip DiBerardino (GDRS) Edward...120-F GPS/IRU Scanning LADAR: Very Low Cost LADAR (VLCL) Automotive MMWR Stereo Video: ESO Stereo Module T2 UGV Platform TARDEC developed

  11. Product Information Platform Based on STEP

    Institute of Scientific and Technical Information of China (English)

    WANG Taiyong; ZHANG Zhiwei

    2009-01-01

    The intemational standard ISO 10303.called STEP.has been used to deal with problems in the ex change of product models and the associated data between difierent computer-aided systems.A platform based on STEP for managing product information is presented.This platform includes three components:a product geometry information model,a product feature model and a product visualization model.An information extracting pattern,in which information is extracted from low level elements to high level ones,is adopted in establishing the product geometry information model.Relative elements lists are created based on the extracted product information.With the traversing of these lists,feature extraction methods are proposed,which take advantage of boundary information in product model and avoid the determination of concavity and convexity of curves.Information correlating to features iS stored in a structure named as feature block and the product visualization model iS founded from it.The feature block is used in the platform for information communication and synchronous update among the three components.

  12. Hybrid Photonic Integration on a Polymer Platform

    Directory of Open Access Journals (Sweden)

    Ziyang Zhang

    2015-09-01

    Full Text Available To fulfill the functionality demands from the fast developing optical networks, a hybrid integration approach allows for combining the advantages of various material platforms. We have established a polymer-based hybrid integration platform (polyboard, which provides flexible optical input/ouptut interfaces (I/Os that allow robust coupling of indium phosphide (InP-based active components, passive insertion of thin-film-based optical elements, and on-chip attachment of optical fibers. This work reviews the recent progress of our polyboard platform. On the fundamental level, multi-core waveguides and polymer/silicon nitride heterogeneous waveguides have been fabricated, broadening device design possibilities and enabling 3D photonic integration. Furthermore, 40-channel optical line terminals and compact, bi-directional optical network units have been developed as highly functional, low-cost devices for the wavelength division multiplexed passive optical network. On a larger scale, thermo-optic elements, thin-film elements and an InP gain chip have been integrated on the polyboard to realize a colorless, dual-polarization optical 90° hybrid as the frontend of a coherent receiver. For high-end applications, a wavelength tunable 100Gbaud transmitter module has been demonstrated, manifesting the joint contribution from the polyboard technology, high speed polymer electro-optic modulator, InP driver electronics and ceramic electronic interconnects.

  13. PLATFORM OF TRANSCRIPTION THE OLD ARABIC MANUSCRIPTS

    Directory of Open Access Journals (Sweden)

    Noureddine EL MAKHFI

    2011-06-01

    Full Text Available The old manuscripts kept in libraries are a part of the richest cultural heritage and legacy of civilizations. Digitalization is a solution for the preservation of this cultural and historical heritage, which is very difficult to handle for users. On the other hand, restriction of access to national heritage manuscript is related to the concern to preserve the manuscripts physically manipulated which contribute to their accelerated degradation, takinginto consideration these limitations on access while ensuring preservation of original manuscripts, the solution widely adopted is based partly on the digitization of this heritage manuscript, and partly on the development of management platforms and diffusion of this wealth of knowledge digitized. We propose in this paper a platform of transcription and establishment by annotating images of manuscripts, these annotations are respecting a XML model. The search in the images of a handwritten document, the rich functionality, intuitive user interface, portability, extensibility and the powerful of the XML technology all make the platform of transcription and establishment an ideal explorer for a specialists and readers of ancient Arabic manuscripts.

  14. Instrument platforms for thin-layer chromatography.

    Science.gov (United States)

    Bernard-Savary, Pierre; Poole, Colin F

    2015-11-20

    High performance column and thin-layer chromatography are both instrumental techniques but differ in that column chromatography requires a fully integrated instrument platform with high pressure capability while for thin-layer chromatography separate devices are used for each unit operation, usually at or close to atmospheric pressure, and afford higher flexibility supporting on-line or off-line operation. The unit operations of thin-layer chromatography are defined as sample application, development and evaluation with derivatization as an optional step. The diversity of equipment for each operation contributes to the flexibility of analysis by thin-layer chromatography and supports manual, semi-automated or full-automation of the separation process. Instrument platforms are more than a convenience as they affect performance, repeatability, sample detectability, and time management. The current trend in thin-layer chromatography is to make the unit operations independent of the user so that analysts can perform other tasks while each step is performed. In addition, in thin-layer chromatography it is general practice to separate several samples simultaneously, and instrument platforms are required to accommodate this feature. In this article, we review contemporary instrumentation employed in thin-layer chromatography for sample application, development, derivatization, photodocumentation, densitometric evaluation, and hyphenation with spectroscopic detectors with an emphasis on the variety and performance of commercially available systems. Some suggestions for best practices and avoidance of common mistakes are included. Copyright © 2015 Elsevier B.V. All rights reserved.

  15. Platform Architecture for Decentralized Positioning Systems

    Directory of Open Access Journals (Sweden)

    Zakaria Kasmi

    2017-04-01

    Full Text Available A platform architecture for positioning systems is essential for the realization of a flexible localization system, which interacts with other systems and supports various positioning technologies and algorithms. The decentralized processing of a position enables pushing the application-level knowledge into a mobile station and avoids the communication with a central unit such as a server or a base station. In addition, the calculation of the position on low-cost and resource-constrained devices presents a challenge due to the limited computing, storage capacity, as well as power supply. Therefore, we propose a platform architecture that enables the design of a system with the reusability of the components, extensibility (e.g., with other positioning technologies and interoperability. Furthermore, the position is computed on a low-cost device such as a microcontroller, which simultaneously performs additional tasks such as data collecting or preprocessing based on an operating system. The platform architecture is designed, implemented and evaluated on the basis of two positioning systems: a field strength system and a time of arrival-based positioning system.

  16. Architectural view model for an integration platform

    Directory of Open Access Journals (Sweden)

    Tomasz Górski

    2012-03-01

    Full Text Available The most common architectural view model is "4+1" by Philipe Kruchten. This model presents the views required for a full description of computer system architecture. By contrast, this model seems to be insufficient to describe architecture of integration platform. Definitely lacks the view of integrated business processes. In the serviceoriented approach, one of the basic elements is a contract. It should also be included in the description of the architecture. Moreover, very important are integration mechanisms and mediation flows that should be presented in the description of architecture. Hence the need for integrated services view, and manner of their integration on the enterprise service bus. Use case view should also be extended by stereotypes required for presenting functionality exposed for other computer systems. It is therefore proposed architectural view model “1+5” for an integration platform. This model has following architectural views: Integrated processes, Use Cases, Logical, Integrated Services, Contracts, Deployment. Furthermore, in article was presented new UML profile "UML Profile for Integration Flows". In the profile were placed stereotypes corresponding to integration patterns and mediation mechanisms. It is important, that UML activity diagram was extended and its special form was obtained to model mediation flows on integration platform. Thus was proposed a new UML diagram: mediation flows diagram.

  17. A novel platform device for rodent echocardiography.

    Science.gov (United States)

    Kutschka, Ingo; Sheikh, Ahmad Y; Sista, Ramachandra; Hendry, Stephen L; Chun, Hyung J; Hoyt, Grant; Kutschka, Werner; Pelletier, Marc P; Quertermous, Tom; Wu, Joseph C; Robbins, Robert C

    2007-06-06

    Acquisition of echocardiographic data from rodents is subject to wide variability due to variations in technique. We hypothesize that a dedicated imaging platform can aid in standardization of technique and improve the quality of images obtained. We constructed a device consisting of a boom-mounted steel platform frame (25 x 35 x 3 cm) on which a transparent polyethylene membrane is mounted. The animal is placed onto the membrane and receives continual inhaled anesthesia via an integrated port. The membrane allows for probe positioning from beneath the animal to obtain standard echo-views in left lateral decubitus or prone positions. The frame can be set at any desired angle ranging from 0 to 360 degrees along either the long or short axis. Adult male Sprague-Dawley rats (n = 5) underwent echocardiography (General Electric, Vivid 7, 14 MHz) using the platform. The device allowed for optimal positioning of animals for a variety of standard echocardiographic measurements. Evaluations among all animals showed minimal variability between two different operators and time points. We tested the feasibility of the device for supporting the assessment of cardiac function in a disease model by evaluating a separate cohort of adult male spontaneously hypertensive rats (n = 5) that underwent left anterior descending coronary artery ligation. Serial echocardiography demonstrated statistically significant decreases of fractional shortening and ejection fraction (p rats. Future studies will focus on improving this technology to allow for standardized high-throughput echocardiographic analysis in small animal models of disease.

  18. Toward an E-Government Semantic Platform

    Science.gov (United States)

    Sbodio, Marco Luca; Moulin, Claude; Benamou, Norbert; Barthès, Jean-Paul

    This chapter describes the major aspects of an e-government platform in which semantics underpins more traditional technologies in order to enable new capabilities and to overcome technical and cultural challenges. The design and development of such an e-government Semantic Platform has been conducted with the financial support of the European Commission through the Terregov research project: "Impact of e-government on Territorial Government Services" (Terregov 2008). The goal of this platform is to let local government and government agencies offer online access to their services in an interoperable way, and to allow them to participate in orchestrated processes involving services provided by multiple agencies. Implementing a business process through an electronic procedure is indeed a core goal in any networked organization. However, the field of e-government brings specific constraints to the operations allowed in procedures, especially concerning the flow of private citizens' data: because of legal reasons in most countries, such data are allowed to circulate only from agency to agency directly. In order to promote transparency and responsibility in e-government while respecting the specific constraints on data flows, Terregov supports the creation of centrally controlled orchestrated processes; while the cross agencies data flows are centrally managed, data flow directly across agencies.

  19. Predicting Droplet Formation on Centrifugal Microfluidic Platforms

    Science.gov (United States)

    Moebius, Jacob Alfred

    Centrifugal microfluidics is a widely known research tool for biological sample and water quality analysis. Currently, the standard equipment used for such diagnostic applications include slow, bulky machines controlled by multiple operators. These machines can be condensed into a smaller, faster benchtop sample-to-answer system. Sample processing is an important step taken to extract, isolate, and convert biological factors, such as nucleic acids or proteins, from a raw sample to an analyzable solution. Volume definition is one such step. The focus of this thesis is the development of a model predicting monodispersed droplet formation and the application of droplets as a technique for volume definition. First, a background of droplet microfluidic platforms is presented, along with current biological analysis technologies and the advantages of integrating such technologies onto microfluidic platforms. Second, background and theories of centrifugal microfluidics is given, followed by theories relevant to droplet emulsions. Third, fabrication techniques for centrifugal microfluidic designs are discussed. Finally, the development of a model for predicting droplet formation on the centrifugal microfluidic platform are presented for the rest of the thesis. Predicting droplet formation analytically based on the volumetric flow rates of the continuous and dispersed phases, the ratios of these two flow rates, and the interfacial tension between the continuous and dispersed phases presented many challenges, which will be discussed in this work. Experimental validation was completed using continuous phase solutions of different interfacial tensions. To conclude, prospective applications are discussed with expected challenges.

  20. Platform Architecture for Decentralized Positioning Systems.

    Science.gov (United States)

    Kasmi, Zakaria; Norrdine, Abdelmoumen; Blankenbach, Jörg

    2017-04-26

    A platform architecture for positioning systems is essential for the realization of a flexible localization system, which interacts with other systems and supports various positioning technologies and algorithms. The decentralized processing of a position enables pushing the application-level knowledge into a mobile station and avoids the communication with a central unit such as a server or a base station. In addition, the calculation of the position on low-cost and resource-constrained devices presents a challenge due to the limited computing, storage capacity, as well as power supply. Therefore, we propose a platform architecture that enables the design of a system with the reusability of the components, extensibility (e.g., with other positioning technologies) and interoperability. Furthermore, the position is computed on a low-cost device such as a microcontroller, which simultaneously performs additional tasks such as data collecting or preprocessing based on an operating system. The platform architecture is designed, implemented and evaluated on the basis of two positioning systems: a field strength system and a time of arrival-based positioning system.

  1. Updating the Micro-Tom TILLING platform.

    Science.gov (United States)

    Okabe, Yoshihiro; Ariizumi, Tohru; Ezura, Hiroshi

    2013-03-01

    The dwarf tomato variety Micro-Tom is regarded as a model system for functional genomics studies in tomato. Various tomato genomic tools in the genetic background of Micro-Tom have been established, such as mutant collections, genome information and a metabolomic database. Recent advances in tomato genome sequencing have brought about a significant need for reverse genetics tools that are accessible to the larger community, because a great number of gene sequences have become available from public databases. To meet the requests from the tomato research community, we have developed the Micro-Tom Targeting-Induced Local Lesions IN Genomes (TILLING) platform, which is comprised of more than 5000 EMS-mutagenized lines. The platform serves as a reverse genetics tool for efficiently identifying mutant alleles in parallel with the development of Micro-Tom mutant collections. The combination of Micro-Tom mutant libraries and the TILLING approach enables researchers to accelerate the isolation of desirable mutants for unraveling gene function or breeding. To upgrade the genomic tool of Micro-Tom, the development of a new mutagenized population is underway. In this paper, the current status of the Micro-Tom TILLING platform and its future prospects are described.

  2. Siberian Platform: Geology and Natural Bitumen Resources

    Science.gov (United States)

    Meyer, Richard F.; Freeman, P.A.

    2006-01-01

    Summary: The Siberian platform is located between the Yenisey River on the west and the Lena River on the south and east. The Siberian platform is vast in size and inhospitable in its climate. This report is concerned principally with the setting, formation, and potential volumes of natural bitumen. In this report the volumes of maltha and asphalt referred to in the Russian literature are combined to represent natural bitumen. The generation of hydrocarbons and formation of hydrocarbon accumulations are discussed. The sedimentary basins of the Platform are described in terms of the Klemme basin classification system and the conditions controlling formation of natural bitumen. Estimates of in-place bitumen resources are reviewed and evaluated. If the bitumen volume estimate is confined to parts of identified deposits where field observations have verified rock and bitumen grades values, the bitumen resource amounts to about 62 billion barrels of oil in-place. However, estimates of an order of magnitude larger can be obtained if additional speculative and unverified rock volumes and grade measures are included.

  3. Year 2 Report: Protein Function Prediction Platform

    Energy Technology Data Exchange (ETDEWEB)

    Zhou, C E

    2012-04-27

    Upon completion of our second year of development in a 3-year development cycle, we have completed a prototype protein structure-function annotation and function prediction system: Protein Function Prediction (PFP) platform (v.0.5). We have met our milestones for Years 1 and 2 and are positioned to continue development in completion of our original statement of work, or a reasonable modification thereof, in service to DTRA Programs involved in diagnostics and medical countermeasures research and development. The PFP platform is a multi-scale computational modeling system for protein structure-function annotation and function prediction. As of this writing, PFP is the only existing fully automated, high-throughput, multi-scale modeling, whole-proteome annotation platform, and represents a significant advance in the field of genome annotation (Fig. 1). PFP modules perform protein functional annotations at the sequence, systems biology, protein structure, and atomistic levels of biological complexity (Fig. 2). Because these approaches provide orthogonal means of characterizing proteins and suggesting protein function, PFP processing maximizes the protein functional information that can currently be gained by computational means. Comprehensive annotation of pathogen genomes is essential for bio-defense applications in pathogen characterization, threat assessment, and medical countermeasure design and development in that it can short-cut the time and effort required to select and characterize protein biomarkers.

  4. 21 CFR 890.3940 - Wheelchair platform scale.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Wheelchair platform scale. 890.3940 Section 890...) MEDICAL DEVICES PHYSICAL MEDICINE DEVICES Physical Medicine Prosthetic Devices § 890.3940 Wheelchair platform scale. (a) Identification. A wheelchair platform scale is a device with a base designed...

  5. On the notion of abstract platform in MDA development

    NARCIS (Netherlands)

    Andrade Almeida, João; Dijkman, R.M.; van Sinderen, Marten J.; Ferreira Pires, Luis

    2004-01-01

    Although platform-independence is a central property in MDA models, the study of platform-independence has been largely overlooked in MDA. As a consequence, there is a lack of guidelines to select abstraction criteria and modelling concepts for platform-independent design. In addition, there is

  6. Tethered acoustic doppler current profiler platforms for measuring streamflow

    Science.gov (United States)

    Rehmel, Michael S.; Stewart, James A.; Morlock, Scott E.

    2003-01-01

    The U.S. Geological Survey tested and refined tethered-platform designs for measuring streamflow. Platform specifications were developed, radio-modem telemetry of acoustic Doppler current profiler (ADCP) data and potential platform-hull sources were investigated, and hulls were tested and evaluated.

  7. On the Notion of Abstract Platform in MDA Development

    NARCIS (Netherlands)

    Almeida, João Paulo; Dijkman, Remco; Sinderen, van Marten; Ferreira Pires, Luis

    2004-01-01

    Although platform-independence is a central property in MDA models, the study of platform-independence has been largely overlooked in MDA. As a consequence, there is a lack of guidelines to select abstraction criteria and modelling concepts for platform-independent design. In addition, there is litt

  8. Product platform life cycles : a multiple case study

    NARCIS (Netherlands)

    Wortmann, Hans; Alblas, Alex

    2009-01-01

    Product platforms are used to specify a (virtual) company's offering to the market in terms of functionality and performance. The specification covers a rang e of actual products and services and the platform includes choice features, options and external interfaces. Usually, the platform also

  9. Picture Compilation in Multi-Platform Sensor Networks

    NARCIS (Netherlands)

    Theil, A.; Bergmans, J.; Broek, S.P. van den; Huizing, A.G.; Kester, L.J.H.M.

    2006-01-01

    The traditional approach to maritime operations in open ocean conditions (‘blue waters’) is platform centric. In this approach, an environmental picture is generated on each platform separately. High quality tracks can be made available to other platforms through classic data links, e.g. Link 11 and

  10. D3.2a Final ECO Platform Architecture Design

    NARCIS (Netherlands)

    Loozen, Kjeld; Viñuales, Javier; Ternier, Stefaan

    2016-01-01

    This deliverable presents the ECO platform architecture. It reports on the outcomes of the work so far conducted under task T3.2: Overall platform architecture. It specifies all components that will constitute the ECO platform and describes the connection to each other.

  11. Complementor embeddedness in platform ecosystems : The case of google apps

    NARCIS (Netherlands)

    Angeren, van J.; Blijleven, V.B; Jansen, S.; Brinkkemper, S.

    2013-01-01

    Platforms and their marketplaces with complementarities are prominent in the software industry. As the proprietary platform itself exhibits elementary or generic functionality, platform owners depend on a complementor ecosystem populated by third-parties. At present, little is known about mechanisms

  12. Product platform life cycles : a multiple case study

    NARCIS (Netherlands)

    Wortmann, Hans; Alblas, Alex

    2009-01-01

    Product platforms are used to specify a (virtual) company's offering to the market in terms of functionality and performance. The specification covers a rang e of actual products and services and the platform includes choice features, options and external interfaces. Usually, the platform also speci

  13. Towards a service platform for mobile context-aware applications

    NARCIS (Netherlands)

    Dockhorn Costa, P.; Ferreira Pires, L.; Sinderen, van M.J.; Pereira Filho, J.G.; Mostefaoui, S.K.; Maarmar, Z.; Rana, O.F.

    2004-01-01

    Context-aware services platforms aim at supporting the handling of contextual information in order to provide better user-tailored services. This paper proposes a novel services platform architecture to support mobile context-aware applications, giving emphasis to the configurability of the platform

  14. GEMBus based services composition platform for cloud PaaS

    NARCIS (Netherlands)

    Demchenko, Y.; Ngo, C.; Martínez-Julia, P.; Torroglosa, E.; Grammatikou, M.; Jofre, J.; Gheorghiu, S.; Garcia-Espin, J.A.; Perez-Morales, A.D.; de Laat, C.

    2012-01-01

    Cloud Platform as a Service (PaaS) provides an environment for creating and deploying applications using one of popular development platforms. This paper presents a practical solution for building a service composition platform based on the GEMBus (GEANT Multi-domain Bus) that extends the industry a

  15. D3.2a Final ECO Platform Architecture Design

    NARCIS (Netherlands)

    Loozen, Kjeld; Viñuales, Javier; Ternier, Stefaan

    2016-01-01

    This deliverable presents the ECO platform architecture. It reports on the outcomes of the work so far conducted under task T3.2: Overall platform architecture. It specifies all components that will constitute the ECO platform and describes the connection to each other.

  16. Stress analysis of portable safety platform (Core Sampler Truck)

    Energy Technology Data Exchange (ETDEWEB)

    Ziada, H.H.

    1995-03-30

    This document provides the stress analysis and evaluation of the portable platform of the rotary mode core sampler truck No. 2 (RMCST {number_sign}2). The platform comprises railing, posts, deck, legs, and a portable ladder; it is restrained from lateral motion by means of two brackets added to the drill-head service platform.

  17. Identification of acquired antimicrobial resistance genes

    DEFF Research Database (Denmark)

    Zankari, Ea; Hasman, Henrik; Cosentino, Salvatore

    2012-01-01

    ObjectivesIdentification of antimicrobial resistance genes is important for understanding the underlying mechanisms and the epidemiology of antimicrobial resistance. As the costs of whole-genome sequencing (WGS) continue to decline, it becomes increasingly available in routine diagnostic laborato......ObjectivesIdentification of antimicrobial resistance genes is important for understanding the underlying mechanisms and the epidemiology of antimicrobial resistance. As the costs of whole-genome sequencing (WGS) continue to decline, it becomes increasingly available in routine diagnostic...... laboratories and is anticipated to substitute traditional methods for resistance gene identification. Thus, the current challenge is to extract the relevant information from the large amount of generated data.MethodsWe developed a web-based method, ResFinder that uses BLAST for identification of acquired...... antimicrobial resistance genes in whole-genome data. As input, the method can use both pre-assembled, complete or partial genomes, and short sequence reads from four different sequencing platforms. The method was evaluated on 1862 GenBank files containing 1411 different resistance genes, as well as on 23 de...

  18. Oil and Gas Producing Platforms in the Gulf of Mexico, Geographic NAD83, MMS (1998)[platforms_MMS_1998

    Data.gov (United States)

    Louisiana Geographic Information Center — This is a point data set for the location of over 4300 MMS administered platform structures used for oil and gas production in the Gulf of Mexico. Groups of platform...

  19. How should we respond to the emergence of plasmid-mediated colistin resistance in humans and animals?

    Directory of Open Access Journals (Sweden)

    Jaffar A. Al-Tawfiq

    2017-01-01

    Conclusion: The emergence and horizontal transmission of colistin resistance highlights the need for heightened stewardship efforts across the One Health platform for this antibiotic of last resort, and indeed for all antibiotics used in animals and humans.

  20. Aspirin Resistance

    Directory of Open Access Journals (Sweden)

    Khaled Mansour

    2009-01-01

    Full Text Available The development of adverse cardiovascular events despite aspirin use has established an interest in a possible resistance to the drug. Several definitions have been set and various laboratory testing modalities are available. This has led to a wide range of prevalence reports in different clinical entities. The etiologic mechanism has been related to clinical, genetic, and other miscellaneous factors. The clinical implications of this phenomenon are significant and warrant concern. Management strategies are currently limited to dosing alteration and introduction of other anitplatelet agents. However, these measures have not met the expected efficacy or safety.

  1. Insulin Resistance

    DEFF Research Database (Denmark)

    Jensen, Benjamin Anderschou Holbech

    Insulin resistance (IR) is escalating with alarming pace and is no longer restricted to westernized countries. As a forerunner for some of the most serious threats to human health including metabolic syndrome, cardiovascular diseases, and type 2-diabetes, the need for new treatment modalities...... interventions. We further show that improving the inflammatory toning, using fish oil as fat source, protects mice against diet induced obesity and -inflammation while preserving insulin sensitivity, even in the absence of free fatty acid receptor 4. Conversely, HFD-induced intestinal dysbiosis is associated...

  2. Engineering Plants for Geminivirus Resistance with CRISPR/Cas9 System.

    Science.gov (United States)

    Zaidi, Syed Shan-E-Ali; Mansoor, Shahid; Ali, Zahir; Tashkandi, Manal; Mahfouz, Magdy M

    2016-04-01

    The CRISPR/Cas9 system is an efficient genome-editing platform for diverse eukaryotic species, including plants. Recent work harnessed CRISPR/Cas9 technology to engineer resistance to geminiviruses. Here, we discuss opportunities, emerging developments, and potential pitfalls for using this technology to engineer resistance against single and multiple geminivirus infections in plants.

  3. Engineering Plants for Geminivirus Resistance with CRISPR/Cas9 System

    KAUST Repository

    Zaidi, Syed Shan-e-Ali

    2016-02-14

    The CRISPR/Cas9 system is an efficient genome-editing platform for diverse eukaryotic species, including plants. Recent work harnessed CRISPR/Cas9 technology to engineer resistance to geminiviruses. Here, we discuss opportunities, emerging developments, and potential pitfalls for using this technology to engineer resistance against single and multiple geminivirus infections in plants.

  4. Origin, structure and exposure history of a wave-cut platform more than 1 Ma in age at the coast of northern Spain: A multiple cosmogenic nuclide approach

    Science.gov (United States)

    Alvarez-Marrón, J.; Hetzel, R.; Niedermann, S.; Menéndez, R.; Marquínez, J.

    2008-01-01

    Along the Asturian coast of northern Spain an uplifted wave-cut platform extends for ˜ 100 km east-west. The steep cliff which bounds the gently seaward-dipping platform to the north increases in height from 30 m in the west to 100 m in the east and reflects the overall eastward increase in platform elevation. The southern edge of the 2-4 km-wide platform runs along the foothills of the Cantabrian Mountains, as constrained by a high-resolution digital elevation model. The marine platform, which was carved into deformed Paleozoic bedrock with abundant quartzite beds, is largely covered by weathered marine and continental sediments. Quartzite samples from flat bedrock outcrops which are currently not covered by sediment or soil yield cosmogenic nuclide concentrations ( 21Ne, 10Be and 26Al) that demonstrate a long and complex exposure history, including periods of burial with partial or complete shielding from cosmic rays. The combination of multiple cosmogenic nuclides yields a minimum age of 1-2 Ma for the platform. Taking into account (i) the horizontal and vertical extent of the platform, (ii) the high resistance to erosion of the quartzitic bedrock, and (iii) published data on the magnitude of past sea level fluctuations, we suggest that the wave-cut platform formed in the Pliocene. Subvertical faults cutting the platform at high angles to the coastline offset the southern edge of the platform by 20 to 40 m and reactivate the pre-existing anisotropy in the Paleozoic bedrock. Uplift and crustal deformation of the coastal region have occurred after platform formation in the Pliocene and may still be active. The slow deformation of the northern edge of the Iberian plate including the Cantabrian Mountains may result from the ongoing slow convergence at an incipient subduction zone extending along the coast of northern Spain.

  5. A Model Collaborative Platform for Geoscience Education

    Science.gov (United States)

    Fox, S.; Manduca, C. A.; Iverson, E. A.

    2012-12-01

    Over the last decade SERC at Carleton College has developed a collaborative platform for geoscience education that has served dozens of projects, thousands of community authors and millions of visitors. The platform combines a custom technical infrastructure: the SERC Content Management system (CMS), and a set of strategies for building web-resources that can be disseminated through a project site, reused by other projects (with attribution) or accessed via an integrated geoscience education resource drawing from all projects using the platform. The core tools of the CMS support geoscience education projects in building project-specific websites. Each project uses the CMS to engage their specific community in collecting, authoring and disseminating the materials of interest to them. At the same time the use of a shared central infrastructure allows cross-fertilization among these project websites. Projects are encouraged to use common templates and common controlled vocabularies for organizing and displaying their resources. This standardization is then leveraged through cross-project search indexing which allow projects to easily incorporate materials from other projects within their own collection in ways that are relevant and automated. A number of tools are also in place to help visitors move among project websites based on their personal interests. Related links help visitors discover content related topically to their current location that is in a 'separate' project. A 'best bets' feature in search helps guide visitors to pages that are good starting places to explore resources on a given topic across the entire range of hosted projects. In many cases these are 'site guide' pages created specifically to promote a cross-project view of the available resources. In addition to supporting the cross-project exploration of specific themes the CMS also allows visitors to view the combined suite of resources authored by any particular community member. Automatically

  6. Seismicity in the platform regions of Ukraine in the zones of anomalous electrical conductivity

    Science.gov (United States)

    Kushnir, A. N.; Kulik, S. N.; Burakhovich, T. K.

    2013-05-01

    It is established for the first time that there are several regions in Ukraine, in which the earthquakes occurring within platform territory are correlated to the anomalous conductive structures in the Earth's crust and upper mantle. These regions are identified as (1) Donbass and the eastern part of the Dnieper-Donetsk Depression (DDD); (2) eastern margin of the Ingulets-Krivoi Rog suture zone in the area of the Krivoi Rog-Kremenchug fault zone; (3) the western part of the Cis-Azov megablock; (4) the western boundary of the Ukrainian Shield and its slope; (5) North Dobruja and Pre-Dobrujan Depression. The reconstructed tree-dimensional (3D) geoelectrical models of the Earth's crust and upper mantle feature anomalously low values of electric resistivity. The earthquake sources in the platform areas of Ukraine are localized above the top and in the upper parts of the crustal anomalies of electrical conductivity.

  7. Geospatial Data Management Platform for Urban Groundwater

    Science.gov (United States)

    Gaitanaru, D.; Priceputu, A.; Gogu, C. R.

    2012-04-01

    Due to the large amount of civil work projects and research studies, large quantities of geo-data are produced for the urban environments. These data are usually redundant as well as they are spread in different institutions or private companies. Time consuming operations like data processing and information harmonisation represents the main reason to systematically avoid the re-use of data. The urban groundwater data shows the same complex situation. The underground structures (subway lines, deep foundations, underground parkings, and others), the urban facility networks (sewer systems, water supply networks, heating conduits, etc), the drainage systems, the surface water works and many others modify continuously. As consequence, their influence on groundwater changes systematically. However, these activities provide a large quantity of data, aquifers modelling and then behaviour prediction can be done using monitored quantitative and qualitative parameters. Due to the rapid evolution of technology in the past few years, transferring large amounts of information through internet has now become a feasible solution for sharing geoscience data. Furthermore, standard platform-independent means to do this have been developed (specific mark-up languages like: GML, GeoSciML, WaterML, GWML, CityML). They allow easily large geospatial databases updating and sharing through internet, even between different companies or between research centres that do not necessarily use the same database structures. For Bucharest City (Romania) an integrated platform for groundwater geospatial data management is developed under the framework of a national research project - "Sedimentary media modeling platform for groundwater management in urban areas" (SIMPA) financed by the National Authority for Scientific Research of Romania. The platform architecture is based on three components: a geospatial database, a desktop application (a complex set of hydrogeological and geological analysis

  8. Proba-V Mission Exploitation Platform

    Science.gov (United States)

    Goor, Erwin; Dries, Jeroen

    2017-04-01

    VITO and partners developed the Proba-V Mission Exploitation Platform (MEP) as an end-to-end solution to drastically improve the exploitation of the Proba-V (a Copernicus contributing mission) EO-data archive (http://proba-v.vgt.vito.be/), the past mission SPOT-VEGETATION and derived vegetation parameters by researchers, service providers and end-users. The analysis of time series of data (+1PB) is addressed, as well as the large scale on-demand processing of near real-time data on a powerful and scalable processing environment. Furthermore data from the Copernicus Global Land Service is in scope of the platform. From November 2015 an operational Proba-V MEP environment, as an ESA operation service, is gradually deployed at the VITO data center with direct access to the complete data archive. Since autumn 2016 the platform is operational and yet several applications are released to the users, e.g. - A time series viewer, showing the evolution of Proba-V bands and derived vegetation parameters from the Copernicus Global Land Service for any area of interest. - Full-resolution viewing services for the complete data archive. - On-demand processing chains on a powerfull Hadoop/Spark backend e.g. for the calculation of N-daily composites. - Virtual Machines can be provided with access to the data archive and tools to work with this data, e.g. various toolboxes (GDAL, QGIS, GrassGIS, SNAP toolbox, …) and support for R and Python. This allows users to immediately work with the data without having to install tools or download data, but as well to design, debug and test applications on the platform. - A prototype of jupyter Notebooks is available with some examples worked out to show the potential of the data. Today the platform is used by several third party projects to perform R&D activities on the data, and to develop/host data analysis toolboxes. In parallel the platform is further improved and extended. From the MEP PROBA-V, access to Sentinel-2 and landsat data will

  9. Resistant hypertension.

    Science.gov (United States)

    Armario, P; Oliveras, A; de la Sierra, A

    2013-11-01

    A 53 year old woman with hypercholesterolemia treated with statins, with no history of cardiovascular disease, was referred to the Hypertension and Vascular Risk Unit for management of hypertension resistant to 4 antihypertensive agents at full doses. The patient had obesity, with a body mass index of 36.3kg/m(2) and office blood pressure 162/102mm Hg. Physical examination showed no data of interest. glucose 120mg/dl, glycated Hb: 6.4%, albuminuria 68mg/g, kidney function and study of the renin angiotensin system and other biochemical parameters were normal. Echocardiography: left ventricular mass, 131g/m(2) (normal, <110g/m(2)). True resistant hypertension was confirmed by ambulatory monitoring of blood pressure during 24h (153/89mm Hg). Spironolactone treatment (25mg/day) was added and was well tolerated, with no change in renal function and kaliemia within normal (4.1mmol/l) following the treatment. After 8 weeks, blood pressure was well controlled: office blood pressure 132/86mm Hg and 24h-ambulatory blood pressure: 128/79mm Hg. Copyright © 2013 Elsevier España, S.L. All rights reserved.

  10. Methodology for development of risk indicators for offshore platforms

    Energy Technology Data Exchange (ETDEWEB)

    Oeien, K.; Sklet, S. [SINTEF Industrial Management Safety and Reliability (Norway)

    1999-09-01

    This paper presents a generic methodology for development of risk indicators for petroleum installations and a specific set of risk indicators established for one offshore platform. The risk indicators should be used to control the risk during operation of platforms. The methodology is purely risk-based and the basis for development of risk indicators is the platform specific quantitative risk analysis (QRA). In order to identify high risk contributing factors, platform personnel are asked to assess whether and how much the risk influencing factors will change. A brief comparison of probabilistic safety assessment (PSA) for nuclear power plants and quantitative risk analysis (QRA) for petroleum platforms is also given. (au)

  11. The development of an open platform to test ITS solutions

    DEFF Research Database (Denmark)

    Lahrmann, Harry; Agerholm, Niels; Juhl, Jens

    2013-01-01

    This paper presents the ITS Platform Northern Denmark, which is an open platform to test ITS solutions. The platform consists of a new developed GNSS/GPRS On Board Unit installed in nearly 500 cars, a backend server and a specially designed digital road map for ITS applications. The platform...... is open for third part application. This paper presents the platform’s potentials and explains a series of test applications, which are developed on the plat- form. Moreover, a number of new projects, which are planned for ITS Platform is introduced....

  12. Carbonate platform growth and demise offshore Central Vietnam

    DEFF Research Database (Denmark)

    Fyhn, Michael B.W.; Boldreel, Lars Ole; Nielsen, Lars H.;

    2013-01-01

    Fault Zone, the Tuy Hoa Carbonate Platform fringes the continental margin between Da Nang and Nha Trang. Here, platform growth initiated during the Early Miocene and continued until Middle Miocene time when regional uplift led to subaerial exposure, termination of platform growth and karstification...... is interpreted as a consequence of regional uplift and denudation of central and south Indochina starting during Middle Miocene time when the Tuy Hoa Carbonate Platform became subaerially exposed. Stressed carbonate growth conditions on the Triton Carbonate Platform probably resulted from increased inorganic...

  13. Ice-Induced Fatigue Analysis by Spectral Approach for Offshore Jacket Platforms with Ice-Breaking Cones

    Institute of Scientific and Technical Information of China (English)

    YUE Qian-jin; LIU Yuan; ZHANG Ri-xiang; QU Yan; WANG Rui-xue

    2007-01-01

    The spectral methods and ice-induced fatigue analysis are discussed based on Miner's linear cumulative fatigue hypothesis and S-N curve data.According to the long-term data of full-scale tests on the platforms in the Bohai Sea,the ice force spectrum of conical structures and the fatigue environmental model are established.Moreover,the finite element model of JZ20-2MSW platform,an example of ice-induced fatigue analysis,is built with ANSYS software.The mode analysis and dynamic analysis in frequency domain under all kinds of ice fatigue work conditions are carried on,and the fatigue life of the structure is estimated in detail.The methods in this paper can be helpful in ice-induced fatigue analysis of ice-resistant platforms.

  14. A Platform for the Implementation of Adaptive On-line Courses: Description and Teachers’ Point of View

    Directory of Open Access Journals (Sweden)

    Julián Moreno Cadavid

    2014-10-01

    Full Text Available Adaptation is a desirable feature in on-line courses which allows for the consideration of students particular characteristics and needs. However, it is not common for teachers to embrace technologies related to this feature. This phenomenon may be mainly attributed to: a unawareness of appropriate authoring tools, and/or b resistance to their use. Regarding this panorama, this research has two purposes. The first purpose is to present a web platform to create adaptive on-line courses that considers three adaptive functionalities: curriculum sequencing, content presentation and assessment. The second purpose is to present a validation for such platform with real users, more specifically, 51 teachers of K-12. The obtained results show that even if there was general distrust while using the platform, there was also a overall interest in rely on a tool that grants teachers in providing an individualized learning experience.

  15. Fake BTS Attacks of GSM System on Software Radio Platform

    Directory of Open Access Journals (Sweden)

    Yubo Song

    2012-02-01

    Full Text Available The 2G GSM communication system only provides one-way authentication mechanism which just authenticate the identities of mobile users. As we know, this is not resistant to fake BTS attack. But for the huge cost for building a fake BTS before, this kind of attack were not really implemented before. This paper presents an implement of fake BTS based on software radio technologies. Furthermore, this paper discusses two types of fake BTS attacks on our software radio platform. The first attack is IMSI/IMEI catch attack, which can get the mobile phone’s IMSI and IMEI. With this information, attacker can got the track of the man with this phone. The second attack is selective jamming attack. After get the IMSI and IMEI of the mobile phone, the attackers can decide whether the mobile phone is blocked or not. We will analyze the GSM protocol which is relevant to the interception system and later present the performance of such a system by real tests and demonstrate its feasibility.

  16. Mechanical design and test of ROSETTA Platform Louvres

    Science.gov (United States)

    Domingo, Miguel; Ramírez, José Julián

    2003-09-01

    More than one hundred trimetal actuators and three hundred bearings will allow the blades movement in the 14 louvres fitted over the radiators of the ROSETTA S/C. Near the Sun, the blades shall be open to allow the radiators to dissipate heat into space. During the prolonged periods of hibernation and comet rendezvous, the blades shall be close in order to retain as much heat as possible in the spacecraft. SENER design of the Rosetta Platform Louvres consists of a framed array (397×430 mm) of highly specular reflecting blades which are individually pivoted to temperature-sensitive actuators. The novel actuators are trimetallic (traditionally were bimetallic) coil springs enclosed within a housing that is well isolated from the external environment but which maintains good thermal contact with the mounting panel requiring thermal control. The actuators are "calibrated" to cause the associated blades to be fully open and fully closed at prescribed temperatures. As the temperature of the panel begins to increase, the related rise in the actuators temperature creates a thermal moment which forces the louvres blades to open and hence lead to an increase in the radioactive power to space. Similarly, as the panel temperature decreases, the actuators tend to close the blades, which now offer a high resistance to radiation losses.

  17. Towards rapid prototyped convective microfluidic DNA amplification platform

    Science.gov (United States)

    Ajit, Smrithi; Praveen, Hemanth Mithun; Puneeth, S. B.; Dave, Abhishek; Sesham, Bharat; Mohan, K. N.; Goel, Sanket

    2017-02-01

    Today, Polymerase Chain Reaction (PCR) based DNA amplification plays an indispensable role in the field of biomedical research. Its inherent ability to exponentially amplify sample DNA has proven useful for the identification of virulent pathogens like those causing Multiple Drug-Resistant Tuberculosis (MDR-TB). The intervention of Microfluidics technology has revolutionized the concept of PCR from being a laborious and time consuming process into one that is faster, easily portable and capable of being multifunctional. The Microfluidics based PCR outweighs its traditional counterpart in terms of flexibility of varying reaction rate, operation simplicity, need of a fraction of volume and capability of being integrated with other functional elements. The scope of the present work involves the development of a real-time continuous flow microfluidic device, fabricated by 3D printing-governed rapid prototyping method, eventually leading to an automated and robust platform to process multiple DNA samples for detection of MDRTB-associated mutations. The thermal gradient characteristic to the PCR process is produced using peltier units appropriate to the microfluidic environment fully monitored and controlled by a low cost controller driven by a Data Acquisition System. The process efficiency achieved in the microfluidic environment in terms of output per cycle is expected to be on par with the traditional PCR and capable of earning the additional advantages of being faster and minimizing the handling.

  18. Risk Management of P2P Internet Financing Service Platform

    Science.gov (United States)

    Yalei, Li

    2017-09-01

    Since 2005, the world’s first P2P Internet financing service platform Zopa in UK was introduced, in the development of “Internet +” trend, P2P Internet financing service platform has been developed rapidly. In 2007, China’s first P2P platform “filming loan” was established, marking the P2P Internet financing service platform to enter China and the rapid development. At the same time, China’s P2P Internet financing service platform also appeared in different forms of risk. This paper focuses on the analysis of the causes of risk of P2P Internet financing service platform and the performance of risk management process. It provides a solution to the Internet risk management plan, and explains the risk management system of the whole P2P Internet financing service platform and the future development direction.

  19. NCI's Transdisciplinary High Performance Scientific Data Platform

    Science.gov (United States)

    Evans, Ben; Antony, Joseph; Bastrakova, Irina; Car, Nicholas; Cox, Simon; Druken, Kelsey; Evans, Bradley; Fraser, Ryan; Ip, Alex; Kemp, Carina; King, Edward; Minchin, Stuart; Larraondo, Pablo; Pugh, Tim; Richards, Clare; Santana, Fabiana; Smillie, Jon; Trenham, Claire; Wang, Jingbo; Wyborn, Lesley

    2016-04-01

    The Australian National Computational Infrastructure (NCI) manages Earth Systems data collections sourced from several domains and organisations onto a single High Performance Data (HPD) Node to further Australia's national priority research and innovation agenda. The NCI HPD Node has rapidly established its value, currently managing over 10 PBytes of datasets from collections that span a wide range of disciplines including climate, weather, environment, geoscience, geophysics, water resources and social sciences. Importantly, in order to facilitate broad user uptake, maximise reuse and enable transdisciplinary access through software and standardised interfaces, the datasets, associated information systems and processes have been incorporated into the design and operation of a unified platform that NCI has called, the National Environmental Research Data Interoperability Platform (NERDIP). The key goal of the NERDIP is to regularise data access so that it is easily discoverable, interoperable for different domains and enabled for high performance methods. It adopts and implements international standards and data conventions, and promotes scientific integrity within a high performance computing and data analysis environment. NCI has established a rich and flexible computing environment to access to this data, through the NCI supercomputer; a private cloud that supports both domain focused virtual laboratories and in-common interactive analysis interfaces; as well as remotely through scalable data services. Data collections of this importance must be managed with careful consideration of both their current use and the needs of the end-communities, as well as its future potential use, such as transitioning to more advanced software and improved methods. It is therefore critical that the data platform is both well-managed and trusted for stable production use (including transparency and reproducibility), agile enough to incorporate new technological advances and

  20. Platform Chemicals from an Oilseed Biorefinery

    Energy Technology Data Exchange (ETDEWEB)

    Tupy, Mike; Schrodi Yann

    2006-11-06

    The US chemical industry is $460 billion in size where a $150 billion segment of which is non-oxygenated chemicals that is sourced today via petroleum but is addressable by a renewable feedstock if one considers a more chemically reduced feedstock such as vegetable oils. Vegetable oil, due to its chemical functionality, provides a largely untapped opportunity as a renewable chemical source to replace petroleum-derived chemicals and produce platform chemicals unavailable today. This project examined the fertile intersection between the rich building blocks provided by vegetable oils and the enhanced chemical modification capability provided by metathesis chemistry. The technology advanced in this study is the process of ethylene cross-metathesis (referred to as ethenolysis) with vegetable oil and vegetable oil derivatives to manufacture the platform-chemical 9-decenoic acid (or 9DA) and olefin co-products. The project team meet its goals of demonstrating improved catalyst efficiencies of several multiples, deepening the mechanistic understanding of metathesis, synthesis and screening of dozens of new catalysts, designing and modeling commercial processes, and estimating production costs. One demonstrable result of the study was a step change improvement in catalyst turnover number in the ethenolysis of methyl oleate as reported here. We met our key measurable of producing 100 lbs of 9DA at the pilot-scale, which demonstrated ability to scale-up ethenolysis. DOE Project funding had significant positive impact on development of metathetically modified vegetable oils more broadly as the Cargill/Materia partnership, that was able to initiate primarily due to DOE funding, has succeeded in commercializing products, validating metathesis as a platform technology, and expanding a diverse products portfolio in high value and in large volume markets. Opportunities have expanded and business development has gained considerable momentum and enabled further expansion of the

  1. Disposable cartridge biosensor platform for portable diagnostics

    Science.gov (United States)

    Yaras, Yusuf S.; Cakmak, Onur; Gunduz, Ali B.; Saglam, Gokhan; Olcer, Selim; Mostafazadeh, Aref; Baris, Ibrahim; Civitci, Fehmi; Yaralioglu, Goksen G.; Urey, Hakan

    2017-03-01

    We developed two types of cantilever-based biosensors for portable diagnostics applications. One sensor is based on MEMS cantilever chip mounted in a microfluidic channel and the other sensor is based on a movable optical fiber placed across a microfluidic channel. Both types of sensors were aimed at direct mechanical measurement of coagulation time in a disposable cartridge using plasma or whole blood samples. There are several similarities and also some important differences between the MEMS based and the optical fiber based solutions. The aim of this paper is to provide a comparison between the two solutions and the results. For both types of sensors, actuation of the cantilever or the moving fiber is achieved using an electro coil and the readout is optical. Since both the actuation and sensing are remote, no electrical connections are required for the cartridge. Therefore it is possible to build low cost disposable cartridges. The reader unit for the cartridge contains light sources, photodetectors, the electro coil, a heater, analog electronics, and a microprocessor. The reader unit has different optical interfaces for the cartridges that have MEMS cantilevers and moving fibers. MEMS based platform has better sensitivity but optomechanical alignment is a challenge and measurements with whole blood were not possible due to high scattering of light by the red blood cells. Fiber sensor based platform has relaxed optomechanical tolerances, ease of manufacturing, and it allows measurements in whole blood. Both sensors were tested using control plasma samples for activated-Partial-Thromboplastin-Time (aPTT) measurements. Control plasma test results matched with the manufacturer's datasheet. Optical fiber based system was tested for aPTT tests with human whole blood samples and the proposed platform provided repeatable test results making the system method of choice for portable diagnostics.

  2. Seqcrawler: biological data indexing and browsing platform

    Directory of Open Access Journals (Sweden)

    Sallou Olivier

    2012-07-01

    Full Text Available Abstract Background Seqcrawler takes its roots in software like SRS or Lucegene. It provides an indexing platform to ease the search of data and meta-data in biological banks and it can scale to face the current flow of data. While many biological bank search tools are available on the Internet, mainly provided by large organizations to search their data, there is a lack of free and open source solutions to browse one’s own set of data with a flexible query system and able to scale from a single computer to a cloud system. A personal index platform will help labs and bioinformaticians to search their meta-data but also to build a larger information system with custom subsets of data. Results The software is scalable from a single computer to a cloud-based infrastructure. It has been successfully tested in a private cloud with 3 index shards (pieces of index hosting ~400 millions of sequence information (whole GenBank, UniProt, PDB and others for a total size of 600 GB in a fault tolerant architecture (high-availability. It has also been successfully integrated with software to add extra meta-data from blast results to enhance users’ result analysis. Conclusions Seqcrawler provides a complete open source search and store solution for labs or platforms needing to manage large amount of data/meta-data with a flexible and customizable web interface. All components (search engine, visualization and data storage, though independent, share a common and coherent data system that can be queried with a simple HTTP interface. The solution scales easily and can also provide a high availability infrastructure.

  3. Biodiversity information platforms: From standards to interoperability

    Directory of Open Access Journals (Sweden)

    Walter Berendsohn

    2011-11-01

    Full Text Available One of the most serious bottlenecks in the scientific workflows of biodiversity sciences is the need to integrate data from different sources, software applications, and services for analysis, visualisation and publication. For more than a quarter of a century the TDWG Biodiversity Information Standards organisation has a central role in defining and promoting data standards and protocols supporting interoperability between disparate and locally distributed systems. Although often not sufficiently recognized, TDWG standards are the foundation of many popular Biodiversity Informatics applications and infrastructures ranging from small desktop software solutions to large scale international data networks. However, individual scientists and groups of collaborating scientist have difficulties in fully exploiting the potential of standards that are often notoriously complex, lack non-technical documentations, and use different representations and underlying technologies. In the last few years, a series of initiatives such as Scratchpads, the EDIT Platform for Cybertaxonomy, and biowikifarm have started to implement and set up virtual work platforms for biodiversity sciences which shield their users from the complexity of the underlying standards. Apart from being practical work-horses for numerous working processes related to biodiversity sciences, they can be seen as information brokers mediating information between multiple data standards and protocols. The ViBRANT project will further strengthen the flexibility and power of virtual biodiversity working platforms by building software interfaces between them, thus facilitating essential information flows needed for comprehensive data exchange, data indexing, web-publication, and versioning. This work will make an important contribution to the shaping of an international, interoperable, and user-oriented biodiversity information infrastructure.

  4. Microfluidic platforms for plant cells studies.

    Science.gov (United States)

    Sanati Nezhad, A

    2014-09-07

    Conventional methods of plant cell analysis rely on growing plant cells in soil pots or agarose plates, followed by screening the plant phenotypes in traditional greenhouses and growth chambers. These methods are usually costly, need a large number of experiments, suffer from low spatial resolution and disorderly growth behavior of plant cells, with lack of ability to locally and accurately manipulate the plant cells. Microfluidic platforms take advantage of miniaturization for handling small volume of liquids and providing a closed environment, with the purpose of in vitro single cell analysis and characterizing cell response to external cues. These platforms have shown their ability for high-throughput cellular analysis with increased accuracy of experiments, reduced cost and experimental times, versatility in design, ability for large-scale and combinatorial screening, and integration with other miniaturized sensors. Despite extensive research on animal cells within microfluidic environments for high-throughput sorting, manipulation and phenotyping studies, the application of microfluidics for plant cells studies has not been accomplished yet. Novel devices such as RootChip, RootArray, TipChip, and PlantChip developed for plant cells analysis, with high spatial resolution on a micrometer scale mimicking the internal microenvironment of plant cells, offering preliminary results on the capability of microfluidics to conquer the constraints of conventional methods. These devices have been used to study different aspects of plant cell biology such as gene expression, cell biomechanics, cellular mechanism of growth, cell division, and cells fusion. This review emphasizes the advantages of current microfluidic systems for plant science studies, and discusses future prospects of microfluidic platforms for characterizing plant cells response to diverse external cues.

  5. Cytostretch, an Organ-on-Chip Platform

    Directory of Open Access Journals (Sweden)

    Nikolas Gaio

    2016-07-01

    Full Text Available Organ-on-Chips (OOCs are micro-fabricated devices which are used to culture cells in order to mimic functional units of human organs. The devices are designed to simulate the physiological environment of tissues in vivo. Cells in some types of OOCs can be stimulated in situ by electrical and/or mechanical actuators. These actuations can mimic physiological conditions in real tissue and may include fluid or air flow, or cyclic stretch and strain as they occur in the lung and heart. These conditions similarly affect cultured cells and may influence their ability to respond appropriately to physiological or pathological stimuli. To date, most focus has been on devices specifically designed to culture just one functional unit of a specific organ: lung alveoli, kidney nephrons or blood vessels, for example. In contrast, the modular Cytostretch membrane platform described here allows OOCs to be customized to different OOC applications. The platform utilizes silicon-based micro-fabrication techniques that allow low-cost, high-volume manufacturing. We describe the platform concept and its modules developed to date. Membrane variants include membranes with (i through-membrane pores that allow biological signaling molecules to pass between two different tissue compartments; (ii a stretchable micro-electrode array for electrical monitoring and stimulation; (iii micro-patterning to promote cell alignment; and (iv strain gauges to measure changes in substrate stress. This paper presents the fabrication and the proof of functionality for each module of the Cytostretch membrane. The assessment of each additional module demonstrate that a wide range of OOCs can be achieved.

  6. Resistance welding

    DEFF Research Database (Denmark)

    Bay, Niels; Zhang, Wenqi; Rasmussen, Mogens H.

    2003-01-01

    Resistance welding comprises not only the well known spot welding process but also more complex projection welding operations, where excessive plastic deformation of the weld point may occur. This enables the production of complex geometries and material combinations, which are often not possible...... to weld by traditional spot welding operations. Such joining processes are, however, not simple to develop due to the large number of parameters involved. Development has traditionally been carried out by large experimental investigations, but the development of a numerical programme system has changed...... this enabling prediction of the welding performance in details. The paper describes the programme in short and gives examples on industrial applications. Finally investigations of causes for failure in a complex industrial joint of two dissimilar metals are carried out combining numerical modelling...

  7. Resistance welding

    DEFF Research Database (Denmark)

    Bay, Niels; Zhang, Wenqi; Rasmussen, Mogens H.

    2003-01-01

    this enabling prediction of the welding performance in details. The paper describes the programme in short and gives examples on industrial applications. Finally investigations of causes for failure in a complex industrial joint of two dissimilar metals are carried out combining numerical modelling......Resistance welding comprises not only the well known spot welding process but also more complex projection welding operations, where excessive plastic deformation of the weld point may occur. This enables the production of complex geometries and material combinations, which are often not possible...... to weld by traditional spot welding operations. Such joining processes are, however, not simple to develop due to the large number of parameters involved. Development has traditionally been carried out by large experimental investigations, but the development of a numerical programme system has changed...

  8. Smart SOA platforms in cloud computing architectures

    CERN Document Server

    Exposito , Ernesto

    2014-01-01

    This book is intended to introduce the principles of the Event-Driven and Service-Oriented Architecture (SOA 2.0) and its role in the new interconnected world based on the cloud computing architecture paradigm. In this new context, the concept of "service" is widely applied to the hardware and software resources available in the new generation of the Internet. The authors focus on how current and future SOA technologies provide the basis for the smart management of the service model provided by the Platform as a Service (PaaS) layer.

  9. Analytical laboratory and mobile sampling platform

    Energy Technology Data Exchange (ETDEWEB)

    Stetzenbach, K.; Smiecinski, A.

    1996-04-30

    This is the final report for the Analytical Laboratory and Mobile Sampling Platform project. This report contains only major findings and conclusions resulting from this project. Detailed reports of all activities performed for this project were provided to the Project Office every quarter since the beginning of the project. This report contains water chemistry data for samples collected in the Nevada section of Death Valley National Park (Triangle Area Springs), Nevada Test Site springs, Pahranagat Valley springs, Nevada Test Site wells, Spring Mountain springs and Crater Flat and Amargosa Valley wells.

  10. Determinants of health: a progressive political platform.

    Science.gov (United States)

    Terris, M

    1994-01-01

    This paper is based on the statement in the Ottawa Charter for Health Promotion that "The fundamental conditions and resources for health are peace, shelter, education, food, income, a stable eco-system, sustainable resources, social justice and equity. Improvement in health requires a secure foundation in these basic prerequisites." It attempts to formulate a progressive political platform for a number of these prerequisites, offering a series of recommendations regarding education, employment, income, and housing, and urging that the proposed programs be funded by progressive taxation and major reductions in the military budget.

  11. Effective envelope method for Stewart platform workspace

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The workspace of Stewart platform is the intersection of 6 son workspaces of 6 loop chains, so it is important to determine the boundary of the son workspace when locating the boundary of the son workspace. An effectivc envelope method is proposed in this paper. Firstly the envelope theory of a family of singular parameter curve surfaces is used to find the envelope surfaces of the son workspace. Then the numerical method is applied to determine the effective envelope surface. And after that the full boundary of the son workspace, which is the envelope of the effective envelope surfaces, is determined. Finally the workspace can be obtained with a section plane method.

  12. Building a Community-Focused Data Platform

    Energy Technology Data Exchange (ETDEWEB)

    Turk, Matthew J. [Univ. of Illinois, Urbana-Champaign, IL (United States). National Center for Supercomputing Applications (NCSA); Warren, Michael S. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Skillman, Samuel W. [Stanford Univ., CA (United States)

    2014-06-10

    The National Data Service (NDS) presents a broad-reaching vision of integrating discovery, publishing, and sharing of data. Metcalfe's Law states that the value of a network increases with the number of connections in the network, not the number of nodes. The NDS must develop and steward connections not only between data, as is in its vision statement, but between individuals as well. We propose that this be accomplished by explicitly developing it as a platform on which data exploration can be constructed by individual researchers.

  13. Instant HTMl5 2D platformer

    CERN Document Server

    Temple, Aidan

    2013-01-01

    Filled with practical, step-by-step instructions and clear explanations for the most important and useful tasks. The step-by-step approach taken by this book will show you how to develop a 2D HTML5 platformer-based game that you will be able to publish to multiple devices.This book is great for anyone who has an interest in HTML5 games development, and who already has a basic to intermediate grasp on both the HTML markup and JavaScript programming languages. Therefore, due to this requirement, the book will not discuss the inner workings of either of these languages but will instead attempt to

  14. Europa Science Platforms and Kinetic Energy Probes

    Science.gov (United States)

    Hays, C. C.; Klein, G. A.

    2003-01-01

    This presentation will outline a proposed mission for the Jupiter Icy Moons Orbiter (JIMO). The mission outlined will concentrate on an examination of Europa. Some of the primary science goals for the JIMO mission are: 1) to answer broad science questions, 2) improved knowledge of Jovian system; specifically, lunar geological and geophysical properties, 3) chemical composition of Jovian lunar surfaces and subterranean matter, and 4) the search for life. In order to address these issues, the experiment proposed here will deploy orbiting, surface, and subterranean science platforms.

  15. Cyanobacteria as a platform for biofuel production

    Directory of Open Access Journals (Sweden)

    Nicole E Nozzi

    2013-09-01

    Full Text Available Cyanobacteria have great potential as a platform for biofuel production because of their fast growth, ability to fix carbon dioxide gas, and their genetic tractability. Furthermore they do not require fermentable sugars or arable land for growth and so competition with cropland would be greatly reduced. In this perspective we discuss the challenges and areas for improvement most pertinent for advancing cyanobacterial fuel production, including: improving genetic parts, carbon fixation, metabolic flux, nutrient requirements on a large scale, and photosynthetic efficiency using natural light.

  16. Verification of Slam Methods on Ros Platform

    Directory of Open Access Journals (Sweden)

    Radovan Sivý

    2016-09-01

    Full Text Available The paper deals with the problem of experimental vehicle concept for 3D SLAM method based on data from Kinect device. One part of the paper describes the design, implementation and description of the physical model of the experimental vehicle. The second describes an odometry representation with a mathematical model of the Ackerman steering as well. Next describes the ROS platform, which was determined to solve complex robotic tasks. Last part of the paper contains to the evaluation of the results of 3D mapping and localization in unknown space.

  17. Hybrid Integrated Platforms for Silicon Photonics

    Directory of Open Access Journals (Sweden)

    John E. Bowers

    2010-03-01

    Full Text Available A review of recent progress in hybrid integrated platforms for silicon photonics is presented. Integration of III-V semiconductors onto silicon-on-insulator substrates based on two different bonding techniques is compared, one comprising only inorganic materials, the other technique using an organic bonding agent. Issues such as bonding process and mechanism, bonding strength, uniformity, wafer surface requirement, and stress distribution are studied in detail. The application in silicon photonics to realize high-performance active and passive photonic devices on low-cost silicon wafers is discussed. Hybrid integration is believed to be a promising technology in a variety of applications of silicon photonics.

  18. Offshore platform integration and floatover technology

    CERN Document Server

    Liu, Gengshen

    2017-01-01

    This book discusses offshore platform integration technology, focusing on the floatover methodology and its applications. It also addresses topics related to safety and cost-effectiveness, as well as ensuring the success of a project through careful planning and established detailed operation procedure/working manuals, which are rarely found in the published literature. Unlike other publications in this area, the book not only includes details of technology development, but also presents real project cases in the discussion to make it more comprehensible. Each topic is illustrated with carefully created sketches to show the complex operation procedures. .

  19. An Application Development Platform for Neuromorphic Computing

    Energy Technology Data Exchange (ETDEWEB)

    Dean, Mark [University of Tennessee (UT); Chan, Jason [University of Tennessee (UT); Daffron, Christopher [University of Tennessee (UT); Disney, Adam [University of Tennessee (UT); Reynolds, John [University of Tennessee (UT); Rose, Garrett [University of Tennessee (UT); Plank, James [University of Tennessee (UT); Birdwell, John Douglas [University of Tennessee (UT); Schuman, Catherine D [ORNL

    2016-01-01

    Dynamic Adaptive Neural Network Arrays (DANNAs) are neuromorphic computing systems developed as a hardware based approach to the implementation of neural networks. They feature highly adaptive and programmable structural elements, which model arti cial neural networks with spiking behavior. We design them to solve problems using evolutionary optimization. In this paper, we highlight the current hardware and software implementations of DANNA, including their features, functionalities and performance. We then describe the development of an Application Development Platform (ADP) to support efficient application implementation and testing of DANNA based solutions. We conclude with future directions.

  20. Nanosized Selenium: A Novel Platform Technology to Prevent Bacterial Infections

    Science.gov (United States)

    Wang, Qi

    As an important category of bacterial infections, healthcare-associated infections (HAIs) are considered an increasing threat to the safety and health of patients worldwide. HAIs lead to extended hospital stays, contribute to increased medical costs, and are a significant cause of morbidity and mortality. In the United States, infections encountered in the hospital or a health care facility affect more than 1.7 million patients, cost 35.7 billion to 45 billion, and contribute to 88,000 deaths in hospitals annually. The most conventional and widely accepted method to fight against bacterial infections is using antibiotics. However, because of the widespread and sometimes inappropriate use of antibiotics, many strains of bacteria have rapidly developed antibiotic resistance. Those new, stronger bacteria pose serious, worldwide threats to public health and welfare. In 2014, the World Health Organization (WHO) reported antibiotic resistance as a global serious threat that is no longer a prediction for the future but is now reality. It has the potential to affect anyone, of any age, in any country. The most effective strategy to prevent antibiotic resistance is minimizing the use of antibiotics. In recent years, nanomaterials have been investigated as one of the potential substitutes of antibiotics. As a result of their vastly increased ratio of surface area to volume, nanomaterials will likely exert a stronger interaction with bacteria which may affect bacterial growth and propagation. A major concern of most existing antibacterial nanomaterials, like silver nanoparticles, is their potential toxicity. But selenium is a non-metallic material and a required nutrition for the human body, which is recommended by the FDA at a 53 to 60 μg daily intake. Nanosized selenium is considered to be healthier and less toxic compared with many metal-based nanomaterials due to the generation of reactive oxygen species from metals, especially heavy metals. Therefore, the objectives of

  1. A Review of Biomedical Centrifugal Microfluidic Platforms

    Directory of Open Access Journals (Sweden)

    Minghui Tang

    2016-02-01

    Full Text Available Centrifugal microfluidic or lab-on-a-disc platforms have many advantages over other microfluidic systems. These advantages include a minimal amount of instrumentation, the efficient removal of any disturbing bubbles or residual volumes, and inherently available density-based sample transportation and separation. Centrifugal microfluidic devices applied to biomedical analysis and point-of-care diagnostics have been extensively promoted recently. This paper presents an up-to-date overview of these devices. The development of biomedical centrifugal microfluidic platforms essentially covers two categories: (i unit operations that perform specific functionalities, and (ii systems that aim to address certain biomedical applications. With the aim to provide a comprehensive representation of current development in this field, this review summarizes progress in both categories. The advanced unit operations implemented for biological processing include mixing, valving, switching, metering and sequential loading. Depending on the type of sample to be used in the system, biomedical applications are classified into four groups: nucleic acid analysis, blood analysis, immunoassays, and other biomedical applications. Our overview of advanced unit operations also includes the basic concepts and mechanisms involved in centrifugal microfluidics, while on the other hand an outline on reported applications clarifies how an assembly of unit operations enables efficient implementation of various types of complex assays. Lastly, challenges and potential for future development of biomedical centrifugal microfluidic devices are discussed.

  2. Context Management Platform for Tourism Applications

    Science.gov (United States)

    Buján, David; Martín, David; Torices, Ortzi; López-de-Ipiña, Diego; Lamsfus, Carlos; Abaitua, Joseba; Alzua-Sorzabal, Aurkene

    2013-01-01

    The notion of context has been widely studied and there are several authors that have proposed different definitions of context. However, context has not been widely studied in the framework of human mobility and the notion of context has been imported directly from other computing fields without specifically addressing the tourism domain requirements. In order to store and manage context information a context data model and a context management platform are needed. Ontologies have been widely used in context modelling, but many of them are designed to be applied in general ubiquitous computing environments, do not contain specific concepts related to the tourism domain or some approaches do not contain enough concepts to represent context information related to the visitor on the move. That is why we propose a new approach to provide a better solution to model context data in tourism environments, adding more value to our solution reusing data about tourist resources from an Open Data repository and publishing it as Linked Data. We also propose the architecture for a context information management platform based on this context data model. PMID:23797739

  3. Context management platform for tourism applications.

    Science.gov (United States)

    Buján, David; Martín, David; Torices, Ortzi; López-de-Ipiña, Diego; Lamsfus, Carlos; Abaitua, Joseba; Alzua-Sorzabal, Aurkene

    2013-06-24

    The notion of context has been widely studied and there are several authors that have proposed different definitions of context. However, context has not been widely studied in the framework of human mobility and the notion of context has been imported directly from other computing fields without specifically addressing the tourism domain requirements. In order to store and manage context information a context data model and a context management platform are needed. Ontologies have been widely used in context modelling, but many of them are designed to be applied in general ubiquitous computing environments, do not contain specific concepts related to the tourism domain or some approaches do not contain enough concepts to represent context information related to the visitor on the move. That is why we propose a new approach to provide a better solution to model context data in tourism environments, adding more value to our solution reusing data about tourist resources from an Open Data repository and publishing it as Linked Data. We also propose the architecture for a context information management platform based on this context data model.

  4. MULTITASKS-GENERIC PLATFORM VIA WSN

    Directory of Open Access Journals (Sweden)

    Mahmoud Mezghani

    2011-08-01

    Full Text Available In recent years, the use of wireless sensor network invade various areas (domotic/home automationfields, medical, industrial …, which sets up several applications such as control of energy consumptionin the habitat, home entertainment system, security system of the intelligent home, health care, … Eachapplication employed its own platform what restore the system very complex. For thus and in this paper,we proposed only one platform for all applications, that’s qualified to generate endless tasks. It coversmany commands developed with a generic remote control interface created by C# language. This genericinterface is very adaptable & adjusts oneself to TinyOS operating system requirements and able to beaccessed via Internet using 6LoWPAN protocol. Validate the proper operation of this generic platformmulti-tasking is approved on several levels:at the implementation of a proposed solution to control energy consumption in the smart home which thesuggested solution is based on the techniques of scheduling under constraints of resources; at theautomation of habitat and in the overall context of the intelligent home and the other to improve thequality of life and make it more comfortable ;across of the practical assistance and to set monitoring ofthe patient and to keep track of his statement by the doctor and that, whether at home or in the route tothe hospital or in the hospital.

  5. Platform for Distributed 3D Gaming

    Directory of Open Access Journals (Sweden)

    A. Jurgelionis

    2009-01-01

    Full Text Available Video games are typically executed on Windows platforms with DirectX API and require high performance CPUs and graphics hardware. For pervasive gaming in various environments like at home, hotels, or internet cafes, it is beneficial to run games also on mobile devices and modest performance CE devices avoiding the necessity of placing a noisy workstation in the living room or costly computers/consoles in each room of a hotel. This paper presents a new cross-platform approach for distributed 3D gaming in wired/wireless local networks. We introduce the novel system architecture and protocols used to transfer the game graphics data across the network to end devices. Simultaneous execution of video games on a central server and a novel streaming approach of the 3D graphics output to multiple end devices enable the access of games on low cost set top boxes and handheld devices that natively lack the power of executing a game with high-quality graphical output.

  6. Emerging robotic platforms for minimally invasive surgery.

    Science.gov (United States)

    Vitiello, Valentina; Lee, Su-Lin; Cundy, Thomas P; Yang, Guang-Zhong

    2013-01-01

    Recent technological advances in surgery have resulted in the development of a range of new techniques that have reduced patient trauma, shortened hospitalization, and improved diagnostic accuracy and therapeutic outcome. Despite the many appreciated benefits of minimally invasive surgery (MIS) compared to traditional approaches, there are still significant drawbacks associated with conventional MIS including poor instrument control and ergonomics caused by rigid instrumentation and its associated fulcrum effect. The use of robot assistance has helped to realize the full potential of MIS with improved consistency, safety and accuracy. The development of articulated, precision tools to enhance the surgeon's dexterity has evolved in parallel with advances in imaging and human-robot interaction. This has improved hand-eye coordination and manual precision down to micron scales, with the capability of navigating through complex anatomical pathways. In this review paper, clinical requirements and technical challenges related to the design of robotic platforms for flexible access surgery are discussed. Allied technical approaches and engineering challenges related to instrument design, intraoperative guidance, and intelligent human-robot interaction are reviewed. We also highlight emerging designs and research opportunities in the field by assessing the current limitations and open technical challenges for the wider clinical uptake of robotic platforms in MIS.

  7. Hardened Client Platforms for Secure Internet Banking

    Science.gov (United States)

    Ronchi, C.; Zakhidov, S.

    We review the security of e-banking platforms with particular attention to the exploitable attack vectors of three main attack categories: Man-in-the-Middle, Man-in-the-PC and Man-in-the-Browser. It will be shown that the most serious threats come from combination attacks capable of hacking any transaction without the need to control the authentication process. Using this approach, the security of any authentication system can be bypassed, including those using SecureID Tokens, OTP Tokens, Biometric Sensors and Smart Cards. We will describe and compare two recently proposed e-banking platforms, the ZTIC and the USPD, both of which are based on the use of dedicated client devices, but with diverging approaches with respect to the need of hardening the Web client application. It will be shown that the use of a Hardened Browser (or H-Browser) component is critical to force attackers to employ complex and expensive techniques and to reduce the strength and variety of social engineering attacks down to physiological fraud levels.

  8. Platform for setting up interactive virtual environments

    Science.gov (United States)

    Souza, Danilo; Dias, Paulo; Santos, Daniel; Sousa Santos, Beatriz

    2014-02-01

    This paper introduces pSIVE, a platform that allows the easy setting up of Virtual Environments, with interactive information (for instance, a video or a document about a machine that is present in the virtual world) to be accessed for different 3D elements. The main goal is to create for evaluation and training on a virtual factory - but generic enough to be applied in different contexts by non-expert users (academic and touristic for instance). We show some preliminary results obtained from two different scenarios: first a production line of a factory with contextualized information associated to different elements which aimed the training of employees. Second a testing environment, to compare and assess two different selection styles that were integrated in pSIVE and to allow different users to interact with an environment created with pSIVE to collect opinions about the system. The conclusions show that the overall satisfaction was high and the comments will be considered in further platform development.

  9. Venus Atmospheric Maneuverable Platform Science Mission

    Science.gov (United States)

    Polidan, Ronald S.; Lee, Gregory; Ross, Floyd; Sokol, Daniel; Bolisay, Linden

    2015-11-01

    Over the past several years, we have explored a possible new approach to Venus upper atmosphere exploration by applying recent Northrop (non-NASA) development programs and have come up with a new class of exploration vehicle: an atmospheric rover. We will discuss a possible suite of instruments and measurements to study the current climate through detailed characterization of cloud level atmosphere and to understand the processes that control climate on Earth-like planets.Our Venus atmospheric rover concept, the Venus Atmospheric Maneuverable Platform (VAMP), is a hypersonic entry vehicle with an ultra-low ballistic coefficient that transitions to a semi-buoyant air vehicle (AV) after entering the Venus atmosphere. Prior to entry, the AV fully deploys to enable lifting entry and eliminates the need for an aeroshell. The mass savings realized by eliminating the aeroshell allows VAMP to accommodate significantly more instruments compared to previous Venus in situ exploration missions. VAMP targets the global Venus atmosphere between 50-65 km altitudes and would be an ideal, stable platform for atmospheric and surface interaction measurements. We will present a straw man concept of VAMP, including its science instrument accommodation capability and platform’s physical characteristics (mass, power, wingspan, etc). We will discuss the various instrument options.VAMP’s subsonic flight regime starts at ~94 km and after performance of VAMP science.

  10. Mucoadhesive polymeric platforms for controlled drug delivery.

    Science.gov (United States)

    Andrews, Gavin P; Laverty, Thomas P; Jones, David S

    2009-03-01

    The process of mucoadhesion involving a polymeric drug delivery platform is a complex one that includes wetting, adsorption and interpenetration of polymer chains amongst various other processes. The success and degree of mucoadhesion bonding is influenced by various polymer-based properties such as the degree of cross-linking, chain length and the presence of various functional groupings. The attractiveness of mucosal-targeted controlled drug delivery of active pharmaceutical ingredients (APIs), has led formulation scientists to engineer numerous polymeric systems for such tasks. Formulation scientists have at their disposal a range of in vitro and in vivo mucoadhesion testing setups in order to select candidate adhesive drug delivery platforms. As such, mucoadhesive systems have found wide use throughout many mucosal covered organelles for API delivery for local or systemic effect. Evolution of such mucoadhesive formulations has transgressed from first-generation charged hydrophilic polymer networks to more specific second-generation systems based on lectin, thiol and various other adhesive functional groups.

  11. Microbial metabolomics in open microscale platforms

    Science.gov (United States)

    Barkal, Layla J.; Theberge, Ashleigh B.; Guo, Chun-Jun; Spraker, Joe; Rappert, Lucas; Berthier, Jean; Brakke, Kenneth A.; Wang, Clay C. C.; Beebe, David J.; Keller, Nancy P.; Berthier, Erwin

    2016-01-01

    The microbial secondary metabolome encompasses great synthetic diversity, empowering microbes to tune their chemical responses to changing microenvironments. Traditional metabolomics methods are ill-equipped to probe a wide variety of environments or environmental dynamics. Here we introduce a class of microscale culture platforms to analyse chemical diversity of fungal and bacterial secondary metabolomes. By leveraging stable biphasic interfaces to integrate microculture with small molecule isolation via liquid–liquid extraction, we enable metabolomics-scale analysis using mass spectrometry. This platform facilitates exploration of culture microenvironments (including rare media typically inaccessible using established methods), unusual organic solvents for metabolite isolation and microbial mutants. Utilizing Aspergillus, a fungal genus known for its rich secondary metabolism, we characterize the effects of culture geometry and growth matrix on secondary metabolism, highlighting the potential use of microscale systems to unlock unknown or cryptic secondary metabolites for natural products discovery. Finally, we demonstrate the potential for this class of microfluidic systems to study interkingdom communication between fungi and bacteria. PMID:26842393

  12. PEEX Modelling Platform for Seamless Environmental Prediction

    Science.gov (United States)

    Baklanov, Alexander; Mahura, Alexander; Arnold, Stephen; Makkonen, Risto; Petäjä, Tuukka; Kerminen, Veli-Matti; Lappalainen, Hanna K.; Ezau, Igor; Nuterman, Roman; Zhang, Wen; Penenko, Alexey; Gordov, Evgeny; Zilitinkevich, Sergej; Kulmala, Markku

    2017-04-01

    The Pan-Eurasian EXperiment (PEEX) is a multidisciplinary, multi-scale research programme stared in 2012 and aimed at resolving the major uncertainties in Earth System Science and global sustainability issues concerning the Arctic and boreal Northern Eurasian regions and in China. Such challenges include climate change, air quality, biodiversity loss, chemicalization, food supply, and the use of natural resources by mining, industry, energy production and transport. The research infrastructure introduces the current state of the art modeling platform and observation systems in the Pan-Eurasian region and presents the future baselines for the coherent and coordinated research infrastructures in the PEEX domain. The PEEX modeling Platform is characterized by a complex seamless integrated Earth System Modeling (ESM) approach, in combination with specific models of different processes and elements of the system, acting on different temporal and spatial scales. The ensemble approach is taken to the integration of modeling results from different models, participants and countries. PEEX utilizes the full potential of a hierarchy of models: scenario analysis, inverse modeling, and modeling based on measurement needs and processes. The models are validated and constrained by available in-situ and remote sensing data of various spatial and temporal scales using data assimilation and top-down modeling. The analyses of the anticipated large volumes of data produced by available models and sensors will be supported by a dedicated virtual research environment developed for these purposes.

  13. A scalable platform for functional emulsions

    Science.gov (United States)

    Feng, Jie; Nunes, Janine K.; Shin, Sangwoo; Yan, Jing; Kong, Yong Lin; Prud'Homme, Robert K.; Arnaudov, Luben N.; Stoyanov, Simeon D.; Stone, Howard A.

    2015-11-01

    Bubble bursting at interfaces plays an important role in a spectrum of physical and biological phenomena, from foam evolution to mass transport across various interfaces. Recently, bubble bursting at an air/oil/water-with-surfactant compound interface was found to disperse submicrometer oil droplets into the water column (Feng et al. Nature Phys., 2014). Inspired by this observation, we propose a new platform to generate functional oil-in-water nanoemulsions. We place functional materials in the appropriate phase, and document that the bubbling system has the capability to produce nanoemulsions encapsulating quantum dots, silica nanoparticles and lipid molecules. In addition, we demonstrate scaling up of the bubbling system and find that the produced nanoemulsions have good stability for days, which offers the flexibility of further treatments and functionalization. Considering the simplicity and energy efficiency of the new bubbling platform, together with the diversity of products and the potential for mass production, our one-step encapsulation system offers a new toolbox for generating (multi-)functional nanoemulsions and nanoparticles.

  14. Surgical rehearsal platform: potential uses in microsurgery.

    Science.gov (United States)

    Bambakidis, Nicholas C; Selman, Warren R; Sloan, Andrew E

    2013-10-01

    Surgical training has remained remarkably similar in many respects since the early days of halstedian training. Neurosurgery is a demanding field that requires extensive cognitive, perceptive, and technical training. Surgical simulation is a promising approach to facilitate acquiring proficiency in neurosurgical procedures. Simulation can permit mentoring trainees in a "safe" environment. By incorporating images that depict specific abnormalities in actual patients, simulation can provide realistic rehearsal for any given case for both novice and experienced surgeons in much the same way that data acquired from drones can be used to allow pilots to rehearse mission-critical maneuvers in a simulator before taking flight. Most neurosurgical simulators to date have focused on endovascular procedures, spinal procedures, temporal bone dissection, and stereotactic procedures. The use of simulator technology for microsurgery is in its infancy. This article describes a novel simulator technology developed by Surgical Theater LLC (http://www.surgicaltheater.net/home.html) called the Selman Surgical Rehearsal Platform. The platform shows promise for use in intracranial microvascular procedures, which require experience that is becoming increasingly limited for trainees who have to become proficient in more procedures in much less time than ever before.

  15. Supervising simulations with the Prodiguer Messaging Platform

    Science.gov (United States)

    Greenslade, Mark; Carenton, Nicolas; Denvil, Sebastien

    2015-04-01

    At any one moment in time, researchers affiliated with the Institut Pierre Simon Laplace (IPSL) climate modeling group, are running hundreds of global climate simulations. These simulations execute upon a heterogeneous set of High Performance Computing (HPC) environments spread throughout France. The IPSL's simulation execution runtime is called libIGCM (library for IPSL Global Climate Modeling group). libIGCM has recently been enhanced so as to support realtime operational use cases. Such use cases include simulation monitoring, data publication, environment metrics collection, automated simulation control … etc. At the core of this enhancement is the Prodiguer messaging platform. libIGCM now emits information, in the form of messages, for remote processing at IPSL servers in Paris. The remote message processing takes several forms, for example: 1. Persisting message content to database(s); 2. Notifying an operator of changes in a simulation's execution status; 3. Launching rollback jobs upon simulation failure; 4. Dynamically updating controlled vocabularies; 5. Notifying downstream applications such as the Prodiguer web portal; We will describe how the messaging platform has been implemented from a technical perspective and demonstrate the Prodiguer web portal receiving realtime notifications.

  16. Cross-Platform Learning: On the Nature of Children's Learning from Multiple Media Platforms

    Science.gov (United States)

    Fisch, Shalom M.

    2013-01-01

    It is increasingly common for an educational media project to span several media platforms (e.g., TV, Web, hands-on materials), assuming that the benefits of learning from multiple media extend beyond those gained from one medium alone. Yet research typically has investigated learning from a single medium in isolation. This paper reviews several…

  17. Mechanisms of drug resistance: quinolone resistance.

    Science.gov (United States)

    Hooper, David C; Jacoby, George A

    2015-09-01

    Quinolone antimicrobials are synthetic and widely used in clinical medicine. Resistance emerged with clinical use and became common in some bacterial pathogens. Mechanisms of resistance include two categories of mutation and acquisition of resistance-conferring genes. Resistance mutations in one or both of the two drug target enzymes, DNA gyrase and DNA topoisomerase IV, are commonly in a localized domain of the GyrA and ParE subunits of the respective enzymes and reduce drug binding to the enzyme-DNA complex. Other resistance mutations occur in regulatory genes that control the expression of native efflux pumps localized in the bacterial membrane(s). These pumps have broad substrate profiles that include quinolones as well as other antimicrobials, disinfectants, and dyes. Mutations of both types can accumulate with selection pressure and produce highly resistant strains. Resistance genes acquired on plasmids can confer low-level resistance that promotes the selection of mutational high-level resistance. Plasmid-encoded resistance is due to Qnr proteins that protect the target enzymes from quinolone action, one mutant aminoglycoside-modifying enzyme that also modifies certain quinolones, and mobile efflux pumps. Plasmids with these mechanisms often encode additional antimicrobial resistances and can transfer multidrug resistance that includes quinolones. Thus, the bacterial quinolone resistance armamentarium is large.

  18. An integrated approach for gas dispersion, gas explosion and structural impact analysis for an offshore production platform on the Dutch continental shelf

    NARCIS (Netherlands)

    Korndörffer, W.; Schaap, D.; Heijden, A.M.A. van der; Versloot, N.H.A.

    2004-01-01

    The design of an offshore gas production platform has been subjected to an extensive quantitative risk analysis in particular with regard to its resistance to gas explosions loads. It was demonstrated that integration of the physical and structural effects of a gas explosion in an early stage of the

  19. The sustainable nuclear energy technology platform. A vision report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    Nuclear fission energy can deliver safe, sustainable, competitive and practically carbon-free energy to Europe's citizens and industries. Within the framework of the Strategic Energy Technology Plan (SET Plan), the European Commission's stakeholders in this field have formulated a collective vision of the contributions this energy could make towards Europe's transition to a low-carbon energy mix by 2050, with the aim of integrating and expanding R and D capabilities in order to further this objective. The groundwork has been prepared by the stakeholders listed in Annex II, within the framework of two EURATOM FP6 (Sixth Framework Programme) Coordination Actions, namely SNF-TP (Sustainable Nuclear Fission Technology Platform) and PATEROS (Partitioning and Transmutation European Road-map for Sustainable Nuclear Energy), with contributions from Europe's technical safety organisations. This vision report prepares the launch of the European Technology Platform on Sustainable Nuclear Energy (SNE-TP). It proposes a vision for the short-, medium- and long-term development of nuclear fission energy technologies, with the aim of achieving a sustainable production of nuclear energy, a significant progress in economic performance, and a continuous improvement of safety levels as well as resistance to proliferation. In particular, this document proposes road-maps for the development and deployment of potentially sustainable nuclear technologies, as well as actions to harmonize Europe's training and education, whilst renewing its research infrastructures. Public acceptance is also an important issue for the development of nuclear energy. Therefore, research in the fields of nuclear installation safety, protection of workers and populations against radiation, management of all types of waste, and governance methodologies with public participation will be promoted. The proposed road-maps provide the backbone for a strategic research agenda (SRA) to maintain

  20. COCAP - A compact carbon dioxide analyser for airborne platforms

    Science.gov (United States)

    Kunz, Martin; Lavrič, Jošt V.; Jeschag, Wieland; Bryzgalov, Maksym; Hök, Bertil; Heimann, Martin

    2014-05-01

    Airborne platforms are a valuable tool for atmospheric trace gas measurements due to their capability of movement in three dimensions, covering spatial scales from metres to thousands of kilometres. Although crewed research aircraft are flexible in payload and range, their use is limited by high initial and operating costs. Small unmanned aerial vehicles (UAV) have the potential for substantial cost reduction, but require lightweight, miniaturized and energy-efficient scientific equipment. We are developing a COmpact Carbon dioxide analyser for Airborne Platforms (COCAP). It contains a non-dispersive infrared CO2sensor with a nominal full scale of 3000 μmol/mol. Sampled air is dried with magnesium perchlorate before it enters the sensor. This enables measurement of the dry air mole fraction of CO2, as recommended by the World Meteorological Organization. During post-processing, the CO2 measurement is corrected for temperature and pressure variations in the gas line. Allan variance analysis shows that we achieve a precision of better than 0.4 μmol/mol for 10 s averaging time. We plan to monitor the analyser's stability during flight by measuring reference air from a miniature gas tank in regular intervals. Besides CO2, COCAP measures relative humidity, temperature and pressure of ambient air. An on-board GPS receiver delivers accurate timestamps and allows georeferencing. Data is both stored on a microSD card and simultaneously transferred over a wireless serial interface to a ground station for real-time review. The target weight for COCAP is less than 1 kg. We deploy COCAP on a commercially available fixed-wing UAV (Bormatec Explorer) with a wingspan of 2.2 metres. The UAV has high payload capacity (2.5 kg) as well as sufficient space in the fuselage (80x80x600 mm3). It is built from a shock-resistant foam material, which allows quick repair of minor damages in the field. In case of severe damage spare parts are readily available. Calculations suggest that the