WorldWideScience

Sample records for platform integration problems

  1. Development of integrated platform for computational material design

    Energy Technology Data Exchange (ETDEWEB)

    Kiyoshi, Matsubara; Kumi, Itai; Nobutaka, Nishikawa; Akifumi, Kato [Center for Computational Science and Engineering, Fuji Research Institute Corporation (Japan); Hideaki, Koike [Advance Soft Corporation (Japan)

    2003-07-01

    The goal of our project is to design and develop a problem-solving environment (PSE) that will help computational scientists and engineers develop large complicated application software and simulate complex phenomena by using networking and parallel computing. The integrated platform, which is designed for PSE in the Japanese national project of Frontier Simulation Software for Industrial Science, is defined by supporting the entire range of problem solving activity from program formulation and data setup to numerical simulation, data management, and visualization. A special feature of our integrated platform is based on a new architecture called TASK FLOW. It integrates the computational resources such as hardware and software on the network and supports complex and large-scale simulation. This concept is applied to computational material design and the project 'comprehensive research for modeling, analysis, control, and design of large-scale complex system considering properties of human being'. Moreover this system will provide the best solution for developing large and complicated software and simulating complex and large-scaled phenomena in computational science and engineering. A prototype has already been developed and the validation and verification of an integrated platform will be scheduled by using the prototype in 2003. In the validation and verification, fluid-structure coupling analysis system for designing an industrial machine will be developed on the integrated platform. As other examples of validation and verification, integrated platform for quantum chemistry and bio-mechanical system are planned.

  2. Development of integrated platform for computational material design

    International Nuclear Information System (INIS)

    Kiyoshi, Matsubara; Kumi, Itai; Nobutaka, Nishikawa; Akifumi, Kato; Hideaki, Koike

    2003-01-01

    The goal of our project is to design and develop a problem-solving environment (PSE) that will help computational scientists and engineers develop large complicated application software and simulate complex phenomena by using networking and parallel computing. The integrated platform, which is designed for PSE in the Japanese national project of Frontier Simulation Software for Industrial Science, is defined by supporting the entire range of problem solving activity from program formulation and data setup to numerical simulation, data management, and visualization. A special feature of our integrated platform is based on a new architecture called TASK FLOW. It integrates the computational resources such as hardware and software on the network and supports complex and large-scale simulation. This concept is applied to computational material design and the project 'comprehensive research for modeling, analysis, control, and design of large-scale complex system considering properties of human being'. Moreover this system will provide the best solution for developing large and complicated software and simulating complex and large-scaled phenomena in computational science and engineering. A prototype has already been developed and the validation and verification of an integrated platform will be scheduled by using the prototype in 2003. In the validation and verification, fluid-structure coupling analysis system for designing an industrial machine will be developed on the integrated platform. As other examples of validation and verification, integrated platform for quantum chemistry and bio-mechanical system are planned

  3. Integrative structure modeling with the Integrative Modeling Platform.

    Science.gov (United States)

    Webb, Benjamin; Viswanath, Shruthi; Bonomi, Massimiliano; Pellarin, Riccardo; Greenberg, Charles H; Saltzberg, Daniel; Sali, Andrej

    2018-01-01

    Building models of a biological system that are consistent with the myriad data available is one of the key challenges in biology. Modeling the structure and dynamics of macromolecular assemblies, for example, can give insights into how biological systems work, evolved, might be controlled, and even designed. Integrative structure modeling casts the building of structural models as a computational optimization problem, for which information about the assembly is encoded into a scoring function that evaluates candidate models. Here, we describe our open source software suite for integrative structure modeling, Integrative Modeling Platform (https://integrativemodeling.org), and demonstrate its use. © 2017 The Protein Society.

  4. Third-party Reverse logistics platform and method Based on Bilateral Resource Integration

    Directory of Open Access Journals (Sweden)

    Zheng Hong Zhen

    2016-01-01

    Full Text Available Dispersion of reverse logistics resources makes it difficult to create relationships between demanders and providers, thereby the personalized demand for the construction of enterprise reverse logistics cannot be satisfied and the service quality cannot be guaranteed. Aiming at these problems, this paper presents a platform and method of enterprise reverse logistics based on bilateral resource integration (RLBRI. The method creates a third-party reverse logistics platform to accumulate a mass of reverse logistics demanders and providers together. And the platform integrates bilateral resources and acts as an intermediary to establish relationships between two sides. Through the platform, a complete and high-quality business chain for enterprise reverse logistics will be built efficiently. Finally put forward an effective strategy of non-defective reverse logistics depends on the integrity checking service provided by third-party logistics. By using this strategy it can short the distance of non-defective reverse transportation. Computational tests validate the strategy.

  5. Emerging heterogeneous integrated photonic platforms on silicon

    Directory of Open Access Journals (Sweden)

    Fathpour Sasan

    2015-05-01

    Full Text Available Silicon photonics has been established as a mature and promising technology for optoelectronic integrated circuits, mostly based on the silicon-on-insulator (SOI waveguide platform. However, not all optical functionalities can be satisfactorily achieved merely based on silicon, in general, and on the SOI platform, in particular. Long-known shortcomings of silicon-based integrated photonics are optical absorption (in the telecommunication wavelengths and feasibility of electrically-injected lasers (at least at room temperature. More recently, high two-photon and free-carrier absorptions required at high optical intensities for third-order optical nonlinear effects, inherent lack of second-order optical nonlinearity, low extinction ratio of modulators based on the free-carrier plasma effect, and the loss of the buried oxide layer of the SOI waveguides at mid-infrared wavelengths have been recognized as other shortcomings. Accordingly, several novel waveguide platforms have been developing to address these shortcomings of the SOI platform. Most of these emerging platforms are based on heterogeneous integration of other material systems on silicon substrates, and in some cases silicon is integrated on other substrates. Germanium and its binary alloys with silicon, III–V compound semiconductors, silicon nitride, tantalum pentoxide and other high-index dielectric or glass materials, as well as lithium niobate are some of the materials heterogeneously integrated on silicon substrates. The materials are typically integrated by a variety of epitaxial growth, bonding, ion implantation and slicing, etch back, spin-on-glass or other techniques. These wide range of efforts are reviewed here holistically to stress that there is no pure silicon or even group IV photonics per se. Rather, the future of the field of integrated photonics appears to be one of heterogenization, where a variety of different materials and waveguide platforms will be used for

  6. CILogon: An Integrated Identity and Access Management Platform for Science

    Science.gov (United States)

    Basney, J.

    2016-12-01

    When scientists work together, they use web sites and other software to share their ideas and data. To ensure the integrity of their work, these systems require the scientists to log in and verify that they are part of the team working on a particular science problem. Too often, the identity and access verification process is a stumbling block for the scientists. Scientific research projects are forced to invest time and effort into developing and supporting Identity and Access Management (IAM) services, distracting them from the core goals of their research collaboration. CILogon provides an IAM platform that enables scientists to work together to meet their IAM needs more effectively so they can allocate more time and effort to their core mission of scientific research. The CILogon platform enables federated identity management and collaborative organization management. Federated identity management enables researchers to use their home organization identities to access cyberinfrastructure, rather than requiring yet another username and password to log on. Collaborative organization management enables research projects to define user groups for authorization to collaboration platforms (e.g., wikis, mailing lists, and domain applications). CILogon's IAM platform serves the unique needs of research collaborations, namely the need to dynamically form collaboration groups across organizations and countries, sharing access to data, instruments, compute clusters, and other resources to enable scientific discovery. CILogon provides a software-as-a-service platform to ease integration with cyberinfrastructure, while making all software components publicly available under open source licenses to enable re-use. Figure 1 illustrates the components and interfaces of this platform. CILogon has been operational since 2010 and has been used by over 7,000 researchers from more than 170 identity providers to access cyberinfrastructure including Globus, LIGO, Open Science Grid

  7. Design of the Hospital Integrated Information Management System Based on Cloud Platform.

    Science.gov (United States)

    Aijing, L; Jin, Y

    2015-12-01

    At present, the outdated information management style cannot meet the needs of hospital management, and has become the bottleneck of hospital's management and development. In order to improve the integrated management of information, hospitals have increased their investment in integrated information management systems. On account of the lack of reasonable and scientific design, some hospital integrated information management systems have common problems, such as unfriendly interface, poor portability and maintainability, low security and efficiency, lack of interactivity and information sharing. To solve the problem, this paper carries out the research and design of a hospital information management system based on cloud platform, which can realize the optimized integration of hospital information resources and save money.

  8. Integration of DYN3D inside the NURESIM platform

    International Nuclear Information System (INIS)

    Gomez T, A. M.; Sanchez E, V. H.; Kliem, S.; Gommlich, A.; Rohde, U.

    2010-10-01

    The NURISP project (Nuclear Reactor Integrated Simulation Project) is focused on the further development of the European Nuclear Reactor Simulation (NURESIM) platform for advanced numerical reactor design and safety analysis tools. NURESIM is based on an open source platform - called SALOME - that offers flexible and powerful capabilities for pre- and post processing as well as for coupling of multi-physics and multi-scale solutions. The developments within the NURISP project are concentrated in the areas of reactors, physics, thermal hydraulics, multi-physics, and sensitivity and uncertainty methodologies. The aim is to develop experimentally validated advanced simulation tools including capabilities for uncertainty and sensitivity quantification. A unique feature of NURESIM is the flexibility in selecting the solvers for the area of interest and the interpolation and mapping schemes according to the problem under consideration. The Sub Project 3 (S P3) of NURISP is focused on the development of multi-physics methodologies at different scales and covering different physical fields (neutronics, thermal hydraulics and pin mechanics). One of the objectives of S P3 is the development of multi-physics methodologies beyond the state-of-the-art for improved prediction of local safety margins and design at pin-by-pin scale. The Karlsruhe Institute of Technology and the Research Center Dresden-Rossendorf are involved in the integration of the reactor dynamics code DYN3D into the SALOME platform for coupling with a thermal hydraulic sub-channel code (FLICA4) at fuel assembly and pin level. In this paper, the main capabilities of the SALOME platform, the steps for the integration process of DYN3D as well as selected preliminary results obtained for the DYN3D/FLICA4 coupling are presented and discussed. Finally the next steps for the validation of the coupling scheme at fuel assembly and pin basis are given. (Author)

  9. Integrated Production-Distribution Scheduling Problem with Multiple Independent Manufacturers

    Directory of Open Access Journals (Sweden)

    Jianhong Hao

    2015-01-01

    Full Text Available We consider the nonstandard parts supply chain with a public service platform for machinery integration in China. The platform assigns orders placed by a machinery enterprise to multiple independent manufacturers who produce nonstandard parts and makes production schedule and batch delivery schedule for each manufacturer in a coordinate manner. Each manufacturer has only one plant with parallel machines and is located at a location far away from other manufacturers. Orders are first processed at the plants and then directly shipped from the plants to the enterprise in order to be finished before a given deadline. We study the above integrated production-distribution scheduling problem with multiple manufacturers to maximize a weight sum of the profit of each manufacturer under the constraints that all orders are finished before the deadline and the profit of each manufacturer is not negative. According to the optimal condition analysis, we formulate the problem as a mixed integer programming model and use CPLEX to solve it.

  10. InP-based generic foundry platform for photonic integrated circuits

    NARCIS (Netherlands)

    Augustin, L.M.; Lemos Alvares Dos Santos, R.M.; den Haan, E.; Kleijn, S.E.F.; Thijs, P.J.A.; Latkowski, S.; Zhao, D.; Yao, W.; Bolk, J.; Ambrosius, H.P.M.M.; Mingaleev, S.; Richter, A.; Bakker, A.; Korthorst, T.

    2017-01-01

    The standardization of photonic integration processes for InP has led to versatile and easily accessible generic integration platforms. The generic integration platforms enable the realization of a broad range of applications and lead to a dramatic cost reduction in the development costs of photonic

  11. Hybrid Photonic Integration on a Polymer Platform

    Directory of Open Access Journals (Sweden)

    Ziyang Zhang

    2015-09-01

    Full Text Available To fulfill the functionality demands from the fast developing optical networks, a hybrid integration approach allows for combining the advantages of various material platforms. We have established a polymer-based hybrid integration platform (polyboard, which provides flexible optical input/ouptut interfaces (I/Os that allow robust coupling of indium phosphide (InP-based active components, passive insertion of thin-film-based optical elements, and on-chip attachment of optical fibers. This work reviews the recent progress of our polyboard platform. On the fundamental level, multi-core waveguides and polymer/silicon nitride heterogeneous waveguides have been fabricated, broadening device design possibilities and enabling 3D photonic integration. Furthermore, 40-channel optical line terminals and compact, bi-directional optical network units have been developed as highly functional, low-cost devices for the wavelength division multiplexed passive optical network. On a larger scale, thermo-optic elements, thin-film elements and an InP gain chip have been integrated on the polyboard to realize a colorless, dual-polarization optical 90° hybrid as the frontend of a coherent receiver. For high-end applications, a wavelength tunable 100Gbaud transmitter module has been demonstrated, manifesting the joint contribution from the polyboard technology, high speed polymer electro-optic modulator, InP driver electronics and ceramic electronic interconnects.

  12. Surface-Enhanced Raman Spectroscopy Integrated Centrifugal Microfluidics Platform

    DEFF Research Database (Denmark)

    Durucan, Onur

    This PhD thesis demonstrates (i) centrifugal microfluidics disc platform integrated with Au capped nanopillar (NP) substrates for surface-enhanced Raman spectroscopy (SERS) based sensing, and (ii) novel sample analysis concepts achieved by synergistical combination of sensing techniques and minia......This PhD thesis demonstrates (i) centrifugal microfluidics disc platform integrated with Au capped nanopillar (NP) substrates for surface-enhanced Raman spectroscopy (SERS) based sensing, and (ii) novel sample analysis concepts achieved by synergistical combination of sensing techniques...... dense array of NP structures. Furthermore, the wicking assisted nanofiltration procedure was accomplished in centrifugal microfluidics platform and as a result additional sample purification was achieved through the centrifugation process. In this way, the Au coated NP substrate was utilized...

  13. Stabilisation problem in biaxial platform

    Directory of Open Access Journals (Sweden)

    Lindner Tymoteusz

    2016-12-01

    Full Text Available The article describes investigation of rolling ball stabilization problem on a biaxial platform. The aim of the control system proposed here is to stabilize ball moving on a plane in equilibrium point. The authors proposed a control algorithm based on cascade PID and they compared it with another control method. The article shows the results of the accuracy of ball stabilization and influence of applied filter on the signal waveform. The application used to detect the ball position measured by digital camera has been written using a cross platform .Net wrapper to the OpenCV image processing library - EmguCV. The authors used the bipolar stepper motor with dedicated electronic controller. The data between the computer and the designed controller are sent with use of the RS232 standard. The control stand is based on ATmega series microcontroller.

  14. Stabilisation problem in biaxial platform

    Science.gov (United States)

    Lindner, Tymoteusz; Rybarczyk, Dominik; Wyrwał, Daniel

    2016-12-01

    The article describes investigation of rolling ball stabilization problem on a biaxial platform. The aim of the control system proposed here is to stabilize ball moving on a plane in equilibrium point. The authors proposed a control algorithm based on cascade PID and they compared it with another control method. The article shows the results of the accuracy of ball stabilization and influence of applied filter on the signal waveform. The application used to detect the ball position measured by digital camera has been written using a cross platform .Net wrapper to the OpenCV image processing library - EmguCV. The authors used the bipolar stepper motor with dedicated electronic controller. The data between the computer and the designed controller are sent with use of the RS232 standard. The control stand is based on ATmega series microcontroller.

  15. Integrated Spintronic Platforms for Biomolecular Recognition Detection

    Science.gov (United States)

    Martins, V. C.; Cardoso, F. A.; Loureiro, J.; Mercier, M.; Germano, J.; Cardoso, S.; Ferreira, R.; Fonseca, L. P.; Sousa, L.; Piedade, M. S.; Freitas, P. P.

    2008-06-01

    This paper covers recent developments in magnetoresistive based biochip platforms fabricated at INESC-MN, and their application to the detection and quantification of pathogenic waterborn microorganisms in water samples for human consumption. Such platforms are intended to give response to the increasing concern related to microbial contaminated water sources. The presented results concern the development of biological active DNA chips and protein chips and the demonstration of the detection capability of the present platforms. Two platforms are described, one including spintronic sensors only (spin-valve based or magnetic tunnel junction based), and the other, a fully scalable platform where each probe site consists of a MTJ in series with a thin film diode (TFD). Two microfluidic systems are described, for cell separation and concentration, and finally, the read out and control integrated electronics are described, allowing the realization of bioassays with a portable point of care unit. The present platforms already allow the detection of complementary biomolecular target recognition with 1 pM concentration.

  16. Structural Integrity Management for Fixed Offshore Platforms in Malaysia

    OpenAIRE

    Narayanan Sambu Potty; Mohammad Kabir B. Mohd Akram

    2009-01-01

    Structural Integrity Management (SIM) is important for the protection of offshore crew, environment, business assets and company and industry reputation. API RP 2A contained guidelines for assessment of existing platforms mostly for the Gulf of Mexico (GOM). ISO 19902 SIM framework also does not specifically cater for Malaysia. There are about 200 platforms in Malaysia with 90 exceeding their design life. The Petronas Carigali Sdn Bhd (PCSB) uses the Asset Integrity Management ...

  17. Hybrid Integrated Platforms for Silicon Photonics

    Science.gov (United States)

    Liang, Di; Roelkens, Gunther; Baets, Roel; Bowers, John E.

    2010-01-01

    A review of recent progress in hybrid integrated platforms for silicon photonics is presented. Integration of III-V semiconductors onto silicon-on-insulator substrates based on two different bonding techniques is compared, one comprising only inorganic materials, the other technique using an organic bonding agent. Issues such as bonding process and mechanism, bonding strength, uniformity, wafer surface requirement, and stress distribution are studied in detail. The application in silicon photonics to realize high-performance active and passive photonic devices on low-cost silicon wafers is discussed. Hybrid integration is believed to be a promising technology in a variety of applications of silicon photonics.

  18. 2009 Integrated Biorefinery Platform Review Report

    Energy Technology Data Exchange (ETDEWEB)

    Ferrell, John [Office of Energy Efficiency and Renewable Energy (EERE), Washington, DC (United States)

    2009-12-01

    This document summarizes the recommendations and evaluations provided by an independent external panel of experts at the U.S. Department of Energy Biomass Program‘s Integrated Biorefinery (IBR) platform review meeting, held on February 18–19, 2009, at the Westin National Harbor, National Harbor, Maryland.

  19. Hybrid Integrated Platforms for Silicon Photonics

    Directory of Open Access Journals (Sweden)

    John E. Bowers

    2010-03-01

    Full Text Available A review of recent progress in hybrid integrated platforms for silicon photonics is presented. Integration of III-V semiconductors onto silicon-on-insulator substrates based on two different bonding techniques is compared, one comprising only inorganic materials, the other technique using an organic bonding agent. Issues such as bonding process and mechanism, bonding strength, uniformity, wafer surface requirement, and stress distribution are studied in detail. The application in silicon photonics to realize high-performance active and passive photonic devices on low-cost silicon wafers is discussed. Hybrid integration is believed to be a promising technology in a variety of applications of silicon photonics.

  20. Integration of the TNXYZ computer program inside the platform Salome

    International Nuclear Information System (INIS)

    Chaparro V, F. J.

    2014-01-01

    The present work shows the procedure carried out to integrate the code TNXYZ as a calculation tool at the graphical simulation platform Salome. The TNXYZ code propose a numerical solution of the neutron transport equation, in several groups of energy, steady-state and three-dimensional geometry. In order to discretized the variables of the transport equation, the code uses the method of discrete ordinates for the angular variable, and a nodal method for the spatial dependence. The Salome platform is a graphical environment designed for building, editing and simulating mechanical models mainly focused on the industry and unlike other software, in order to form a complete scheme of pre and post processing of information, to integrate and control an external source code. Before the integration the in the Salome platform TNXYZ code was upgraded. TNXYZ was programmed in the 90s using Fortran 77 compiler; for this reason the code was adapted to the characteristics of the current Fortran compilers; in addition, with the intention of extracting partial results over the process sequence, the original structure of the program underwent a modularization process, i.e. the main program was divided into sections where the code performs major operations. This procedure is controlled by the information module (YACS) on Salome platform, and it could be useful for a subsequent coupling with thermal-hydraulics codes. Finally, with the help of the Monte Carlo code Serpent several study cases were defined in order to check the process of integration; the verification process consisted in performing a comparison of the results obtained with the code executed as stand-alone and after modernized, integrated and controlled by the Salome platform. (Author)

  1. Integration of the virtual model of a Stewart platform with the avatar of a vehicle in a virtual reality

    Science.gov (United States)

    Herbuś, K.; Ociepka, P.

    2016-08-01

    The development of methods of computer aided design and engineering allows conducting virtual tests, among others concerning motion simulation of technical means. The paper presents a method of integrating an object in the form of a virtual model of a Stewart platform with an avatar of a vehicle moving in a virtual environment. The area of the problem includes issues related to the problem of fidelity of mapping the work of the analyzed technical mean. The main object of investigations is a 3D model of a Stewart platform, which is a subsystem of the simulator designated for driving learning for disabled persons. The analyzed model of the platform, prepared for motion simulation, was created in the “Motion Simulation” module of a CAD/CAE class system Siemens PLM NX. Whereas the virtual environment, in which the moves the avatar of the passenger car, was elaborated in a VR class system EON Studio. The element integrating both of the mentioned software environments is a developed application that reads information from the virtual reality (VR) concerning the current position of the car avatar. Then, basing on the accepted algorithm, it sends control signals to respective joints of the model of the Stewart platform (CAD).

  2. Efficient Sensor Integration on Platforms (NeXOS)

    Science.gov (United States)

    Memè, S.; Delory, E.; Del Rio, J.; Jirka, S.; Toma, D. M.; Martinez, E.; Frommhold, L.; Barrera, C.; Pearlman, J.

    2016-12-01

    In-situ ocean observing platforms provide power and information transmission capability to sensors. Ocean observing platforms can be mobile, such as ships, autonomous underwater vehicles, drifters and profilers, or fixed, such as buoys, moorings and cabled observatories. The process of integrating sensors on platforms can imply substantial engineering time and resources. Constraints range from stringent mechanical constraints to proprietary communication and control firmware. In NeXOS, the implementation of a PUCK plug and play capability is being done with applications to multiple sensors and platforms. This is complemented with a sensor web enablement that addresses the flow of information from sensor to user. Open standards are being tested in order to assess their costs and benefits in existing and future observing systems. Part of the testing implied open-source coding and hardware prototyping of specific control devices in particular for closed commercial platforms where firmware upgrading is not straightforward or possible without prior agreements or service fees. Some platform manufacturers such as European companies ALSEAMAR[1] and NKE Instruments [2] are currently upgrading their control and communication firmware as part of their activities in NeXOS. The sensor development companies Sensorlab[3] SMID[4] and TRIOS [5]upgraded their firmware with this plug and play functionality. Other industrial players in Europe and the US have been sent NeXOS sensors emulators to test the new protocol on their platforms. We are currently demonstrating that with little effort, it is also possible to have such middleware implemented on very low-cost compact computers such as the open Raspberry Pi[6], and have a full end-to-end interoperable communication path from sensor to user with sensor plug and play capability. The result is an increase in sensor integration cost-efficiency and the demonstration will be used to highlight the benefit to users and ocean observatory

  3. Multi-function microfluidic platform for sensor integration

    DEFF Research Database (Denmark)

    Fernandes, Ana C.; Semenova, Daria; Panjan, Peter

    2018-01-01

    The limited availability of metabolite-specific sensors for continuous sampling and monitoring is one of the main bottlenecks contributing to failures in bioprocess development. Furthermore, only a limited number of approaches exist to connect currently available measurement systems with high...... throughput reactor units. This is especially relevant in the biocatalyst screening and characterization stage of process development. In this work, a strategy for sensor integration in microfluidic platforms is demonstrated, to address the need for rapid, cost-effective and high-throughput screening...... of the sample solution up to 10 times. In order to highlight the features of the proposed platform, inline monitoring of glucose levels is presented and discussed. Glucose was chosen due to its importance in biotechnology as a relevant substrate. The platform demonstrated continuous measurement of substrate...

  4. An ultra-efficient nonlinear planar integrated platform for optical signal processing and generation

    DEFF Research Database (Denmark)

    Pu, Minhao; Ottaviano, Luisa; Semenova, Elizaveta

    2017-01-01

    This paper will discuss the recently developed integrated platform: AlGaAs-oninsulator and its broad range of nonlinear applications. Recent demonstrations of broadband optical signal processing and efficient frequency comb generations in this platform will be reviewed.......This paper will discuss the recently developed integrated platform: AlGaAs-oninsulator and its broad range of nonlinear applications. Recent demonstrations of broadband optical signal processing and efficient frequency comb generations in this platform will be reviewed....

  5. A Versatile Integrated Ambient Ionization Source Platform

    Science.gov (United States)

    Ai, Wanpeng; Nie, Honggang; Song, Shiyao; Liu, Xiaoyun; Bai, Yu; Liu, Huwei

    2018-04-01

    The pursuit of high-throughput sample analysis from complex matrix demands development of multiple ionization techniques with complementary specialties. A versatile integrated ambient ionization source (iAmIS) platform is proposed in this work, based on the idea of integrating multiple functions, enhancing the efficiency of current ionization techniques, extending the applications, and decreasing the cost of the instrument. The design of the iAmIS platform combines flowing atmospheric pressure afterglow (FAPA) source/direct analysis in real time (DART), dielectric barrier discharge ionization (DBDI)/low-temperature plasma (LTP), desorption electrospray ionization (DESI), and laser desorption (LD) technique. All individual and combined ionization modes can be easily attained by modulating parameters. In particular, the FAPA/DART&DESI mode can realize the detection of polar and nonpolar compounds at the same time with two different ionization mechanisms: proton transfer and charge transfer. The introduction of LD contributes to the mass spectrometry imaging and the surface-assisted laser desorption (SALDI) under ambient condition. Compared with other individual or multi-mode ion source, the iAmIS platform provides the flexibility of choosing different ionization modes, broadens the scope of the analyte detection, and facilitates the analysis of complex samples. [Figure not available: see fulltext.

  6. Quantum photonics hybrid integration platform

    Energy Technology Data Exchange (ETDEWEB)

    Murray, E.; Floether, F. F. [Cambridge Research Laboratory, Toshiba Research Europe Limited, 208 Science Park, Milton Road, Cambridge CB4 0GZ (United Kingdom); Cavendish Laboratory, University of Cambridge, J.J. Thomson Avenue, Cambridge CB3 0HE (United Kingdom); Ellis, D. J. P.; Meany, T.; Bennett, A. J., E-mail: anthony.bennet@crl.toshiba.co.uk; Shields, A. J. [Cambridge Research Laboratory, Toshiba Research Europe Limited, 208 Science Park, Milton Road, Cambridge CB4 0GZ (United Kingdom); Lee, J. P. [Cambridge Research Laboratory, Toshiba Research Europe Limited, 208 Science Park, Milton Road, Cambridge CB4 0GZ (United Kingdom); Engineering Department, University of Cambridge, 9 J. J. Thomson Avenue, Cambridge CB3 0FA (United Kingdom); Griffiths, J. P.; Jones, G. A. C.; Farrer, I.; Ritchie, D. A. [Cavendish Laboratory, University of Cambridge, J.J. Thomson Avenue, Cambridge CB3 0HE (United Kingdom)

    2015-10-26

    Fundamental to integrated photonic quantum computing is an on-chip method for routing and modulating quantum light emission. We demonstrate a hybrid integration platform consisting of arbitrarily designed waveguide circuits and single-photon sources. InAs quantum dots (QD) embedded in GaAs are bonded to a SiON waveguide chip such that the QD emission is coupled to the waveguide mode. The waveguides are SiON core embedded in a SiO{sub 2} cladding. A tuneable Mach Zehnder interferometer (MZI) modulates the emission between two output ports and can act as a path-encoded qubit preparation device. The single-photon nature of the emission was verified using the on-chip MZI as a beamsplitter in a Hanbury Brown and Twiss measurement.

  7. Wireless, smartphone controlled potentiostat integrated with lab-on-disc platform

    DEFF Research Database (Denmark)

    Cheng, Chung-Hsiang; Zor, Kinga; Wang, Jen-Hung

    A smartphone controlled wireless data transmitting and inductive powering Power Lab-on-disc (PLoD) platform is developed based on 2.4 GHz Bluetooth and 205 kHz Qi techniques, respectively. A potentiostat is integrated on the PLoD platform, and amperometric measurements are performed. The wireless...

  8. On challenges and opportunities of designing integrated IT platforms for supporting knowledge works in organizations

    OpenAIRE

    Laha, Arijit

    2009-01-01

    Designing and implementing comprehensive IT-based support environments for KM in organizations is fraught with many problems. Solving them requires intimate knowledge about the information usage in knowledge works and the scopes of technology intervention. In this paper, the Task-oriented Organizational Knowledge Management or TOKM, a design theory for building integrated IT platforms for supporting organizational KM, is proposed. TOKM brings together two apparently mutually exclusive practic...

  9. Solving the Problem of Comparing Whole Bacterial Genomes across Different Sequencing Platforms

    DEFF Research Database (Denmark)

    Kaas, Rolf Sommer; Leekitcharoenphon, Pimlapas; Aarestrup, Frank Møller

    2014-01-01

    technology because each technology has a systematic bias making integration of data generated from different platforms difficult. We developed two different procedures for identifying variable sites and inferring phylogenies in WGS data across multiple platforms. The methods were evaluated on three bacterial...

  10. A middleware-based platform for the integration of bioinformatic services

    Directory of Open Access Journals (Sweden)

    Guzmán Llambías

    2015-08-01

    Full Text Available Performing Bioinformatic´s experiments involve an intensive access to distributed services and information resources through Internet. Although existing tools facilitate the implementation of workflow-oriented applications, they lack of capabilities to integrate services beyond low-scale applications, particularly integrating services with heterogeneous interaction patterns and in a larger scale. This is particularly required to enable a large-scale distributed processing of biological data generated by massive sequencing technologies. On the other hand, such integration mechanisms are provided by middleware products like Enterprise Service Buses (ESB, which enable to integrate distributed systems following a Service Oriented Architecture. This paper proposes an integration platform, based on enterprise middleware, to integrate Bioinformatics services. It presents a multi-level reference architecture and focuses on ESB-based mechanisms to provide asynchronous communications, event-based interactions and data transformation capabilities. The paper presents a formal specification of the platform using the Event-B model.

  11. Aluminum nitride integrated photonics platform for the ultraviolet to visible spectrum.

    Science.gov (United States)

    Lu, Tsung-Ju; Fanto, Michael; Choi, Hyeongrak; Thomas, Paul; Steidle, Jeffrey; Mouradian, Sara; Kong, Wei; Zhu, Di; Moon, Hyowon; Berggren, Karl; Kim, Jeehwan; Soltani, Mohammad; Preble, Stefan; Englund, Dirk

    2018-04-30

    We demonstrate a wide-bandgap semiconductor photonics platform based on nanocrystalline aluminum nitride (AlN) on sapphire. This photonics platform guides light at low loss from the ultraviolet (UV) to the visible spectrum. We measure ring resonators with intrinsic quality factor (Q) exceeding 170,000 at 638 nm and Q >20,000 down to 369.5 nm, which shows a promising path for low-loss integrated photonics in UV and visible spectrum. This platform opens up new possibilities in integrated quantum optics with trapped ions or atom-like color centers in solids, as well as classical applications including nonlinear optics and on-chip UV-spectroscopy.

  12. Selected Problems of Sensitivity and Reliability of a Jack-Up Platform

    Directory of Open Access Journals (Sweden)

    Rozmarynowski Bogdan

    2018-03-01

    Full Text Available The paper deals with sensitivity and reliability applications to numerical studies of an off-shore platform model. Structural parameters and sea conditions are referred to the Baltic jack-up drilling platform. The sudy aims at the influence of particular basic variables on static and dynamic response as well as the probability of failure due to water waves and wind loads. The paper presents the sensitivity approach to a generalized eigenvalue problem and evaluation of the performace functions. The first order time-invariant problems of structural reliability analysis are under concern.

  13. Design and Analysis of a Compact Precision Positioning Platform Integrating Strain Gauges and the Piezoactuator

    Directory of Open Access Journals (Sweden)

    Shunguang Wan

    2012-07-01

    Full Text Available Miniaturization precision positioning platforms are needed for in situ nanomechanical test applications. This paper proposes a compact precision positioning platform integrating strain gauges and the piezoactuator. Effects of geometric parameters of two parallel plates on Von Mises stress distribution as well as static and dynamic characteristics of the platform were studied by the finite element method. Results of the calibration experiment indicate that the strain gauge sensor has good linearity and its sensitivity is about 0.0468 mV/μm. A closed-loop control system was established to solve the problem of nonlinearity of the platform. Experimental results demonstrate that for the displacement control process, both the displacement increasing portion and the decreasing portion have good linearity, verifying that the control system is available. The developed platform has a compact structure but can realize displacement measurement with the embedded strain gauges, which is useful for the closed-loop control and structure miniaturization of piezo devices. It has potential applications in nanoindentation and nanoscratch tests, especially in the field of in situ nanomechanical testing which requires compact structures.

  14. KinomeXplorer: an integrated platform for kinome biology studies

    DEFF Research Database (Denmark)

    Horn, Heiko; Schoof, Erwin; Kim, Jinho

    2014-01-01

    A letter to the editor is presented related to the KinomeXplorer, an integrated platform providing workflows to efficiently analyze phosphorylation dependent interaction networks or kinase signaling networks....

  15. Study on integrated design and analysis platform of NPP

    International Nuclear Information System (INIS)

    Lu Dongsen; Gao Zuying; Zhou Zhiwei

    2001-01-01

    Many calculation software have been developed to nuclear system's design and safety analysis, such as structure design software, fuel design and manage software, thermal hydraulic analysis software, severe accident simulation software, etc. This study integrates those software to a platform, develops visual modeling tool for Retran, NGFM90. And in this platform, a distribution calculation method is also provided for couple calculation between different software. The study will improve the design and analysis of NPP

  16. Multi-function microfluidic platform for sensor integration.

    Science.gov (United States)

    Fernandes, Ana C; Semenova, Daria; Panjan, Peter; Sesay, Adama M; Gernaey, Krist V; Krühne, Ulrich

    2018-03-06

    The limited availability of metabolite-specific sensors for continuous sampling and monitoring is one of the main bottlenecks contributing to failures in bioprocess development. Furthermore, only a limited number of approaches exist to connect currently available measurement systems with high throughput reactor units. This is especially relevant in the biocatalyst screening and characterization stage of process development. In this work, a strategy for sensor integration in microfluidic platforms is demonstrated, to address the need for rapid, cost-effective and high-throughput screening in bioprocesses. This platform is compatible with different sensor formats by enabling their replacement and was built in order to be highly flexible and thus suitable for a wide range of applications. Moreover, this re-usable platform can easily be connected to analytical equipment, such as HPLC, laboratory scale reactors or other microfluidic chips through the use of standardized fittings. In addition, the developed platform includes a two-sensor system interspersed with a mixing channel, which allows the detection of samples that might be outside the first sensor's range of detection, through dilution of the sample solution up to 10 times. In order to highlight the features of the proposed platform, inline monitoring of glucose levels is presented and discussed. Glucose was chosen due to its importance in biotechnology as a relevant substrate. The platform demonstrated continuous measurement of substrate solutions for up to 12 h. Furthermore, the influence of the fluid velocity on substrate diffusion was observed, indicating the need for in-flow calibration to achieve a good quantitative output. Copyright © 2018 Elsevier B.V. All rights reserved.

  17. A hybrid approach to device integration on a genetic analysis platform

    International Nuclear Information System (INIS)

    Brennan, Des; Justice, John; Aherne, Margaret; Galvin, Paul; Jary, Dorothee; Kurg, Ants; Berik, Evgeny; Macek, Milan

    2012-01-01

    Point-of-care (POC) systems require significant component integration to implement biochemical protocols associated with molecular diagnostic assays. Hybrid platforms where discrete components are combined in a single platform are a suitable approach to integration, where combining multiple device fabrication steps on a single substrate is not possible due to incompatible or costly fabrication steps. We integrate three devices each with a specific system functionality: (i) a silicon electro-wetting-on-dielectric (EWOD) device to move and mix sample and reagent droplets in an oil phase, (ii) a polymer microfluidic chip containing channels and reservoirs and (iii) an aqueous phase glass microarray for fluorescence microarray hybridization detection. The EWOD device offers the possibility of fully integrating on-chip sample preparation using nanolitre sample and reagent volumes. A key challenge is sample transfer from the oil phase EWOD device to the aqueous phase microarray for hybridization detection. The EWOD device, waveguide performance and functionality are maintained during the integration process. An on-chip biochemical protocol for arrayed primer extension (APEX) was implemented for single nucleotide polymorphism (SNiP) analysis. The prepared sample is aspirated from the EWOD oil phase to the aqueous phase microarray for hybridization. A bench-top instrumentation system was also developed around the integrated platform to drive the EWOD electrodes, implement APEX sample heating and image the microarray after hybridization. (paper)

  18. Genomics Portals: integrative web-platform for mining genomics data.

    Science.gov (United States)

    Shinde, Kaustubh; Phatak, Mukta; Johannes, Freudenberg M; Chen, Jing; Li, Qian; Vineet, Joshi K; Hu, Zhen; Ghosh, Krishnendu; Meller, Jaroslaw; Medvedovic, Mario

    2010-01-13

    A large amount of experimental data generated by modern high-throughput technologies is available through various public repositories. Our knowledge about molecular interaction networks, functional biological pathways and transcriptional regulatory modules is rapidly expanding, and is being organized in lists of functionally related genes. Jointly, these two sources of information hold a tremendous potential for gaining new insights into functioning of living systems. Genomics Portals platform integrates access to an extensive knowledge base and a large database of human, mouse, and rat genomics data with basic analytical visualization tools. It provides the context for analyzing and interpreting new experimental data and the tool for effective mining of a large number of publicly available genomics datasets stored in the back-end databases. The uniqueness of this platform lies in the volume and the diversity of genomics data that can be accessed and analyzed (gene expression, ChIP-chip, ChIP-seq, epigenomics, computationally predicted binding sites, etc), and the integration with an extensive knowledge base that can be used in such analysis. The integrated access to primary genomics data, functional knowledge and analytical tools makes Genomics Portals platform a unique tool for interpreting results of new genomics experiments and for mining the vast amount of data stored in the Genomics Portals backend databases. Genomics Portals can be accessed and used freely at http://GenomicsPortals.org.

  19. Full scale test platform for European TBM systems integration and maintenance

    Energy Technology Data Exchange (ETDEWEB)

    Vála, Ladislav, E-mail: ladislav.vala@cvrez.cz; Reungoat, Mathieu; Vician, Martin

    2016-11-01

    Highlights: • A platform for EU-TBS maintenance and integration tests is described. • Its modular design allows adaptation to non-EU TBSs. • Assembling of the facility will be followed by initial tests in 2016. - Abstract: This article deals with description and current status of a project of a non-nuclear, full size (1:1 scale) test platform dedicated to tests, optimization and validation of integration and maintenance operations for the European TBM systems in the ITER port cell #16. The facility called TBM platform reproduces the ITER port cell #16 and port interspace with all the relevant interfaces and mock-ups of the corresponding main components. Thanks to the modular design of the platform, it is possible to adapt or change completely the interfaces in the future if needed or required according to the updated configuration of TBSs. In the same way, based on customer requirements, it will be possible to adapt the interfaces and piping inside the mock-ups in order to represent also the other, non-EU configurations of TBM systems designed for port cells #02 and #18. Construction of this test platform is realized and funded within the scope of the SUSEN project.

  20. Study on the E-commerce platform based on the agent

    Science.gov (United States)

    Fu, Ruixue; Qin, Lishuan; Gao, Yinmin

    2011-10-01

    To solve problem of dynamic integration in e-commerce, the Multi-Agent architecture of electronic commerce platform system based on Agent and Ontology has been introduced, which includes three major types of agent, Ontology and rule collection. In this architecture, service agent and rule are used to realize the business process reengineering, the reuse of software component, and agility of the electronic commerce platform. To illustrate the architecture, a simulation work has been done and the results imply that the architecture provides a very efficient method to design and implement the flexible, distributed, open and intelligent electronic commerce platform system to solve problem of dynamic integration in ecommerce. The objective of this paper is to illustrate the architecture of electronic commerce platform system, and the approach how Agent and Ontology support the electronic commerce platform system.

  1. An integrated biotechnology platform for developing sustainable chemical processes.

    Science.gov (United States)

    Barton, Nelson R; Burgard, Anthony P; Burk, Mark J; Crater, Jason S; Osterhout, Robin E; Pharkya, Priti; Steer, Brian A; Sun, Jun; Trawick, John D; Van Dien, Stephen J; Yang, Tae Hoon; Yim, Harry

    2015-03-01

    Genomatica has established an integrated computational/experimental metabolic engineering platform to design, create, and optimize novel high performance organisms and bioprocesses. Here we present our platform and its use to develop E. coli strains for production of the industrial chemical 1,4-butanediol (BDO) from sugars. A series of examples are given to demonstrate how a rational approach to strain engineering, including carefully designed diagnostic experiments, provided critical insights about pathway bottlenecks, byproducts, expression balancing, and commercial robustness, leading to a superior BDO production strain and process.

  2. An integrated platform for biomolecule interaction analysis

    Science.gov (United States)

    Jan, Chia-Ming; Tsai, Pei-I.; Chou, Shin-Ting; Lee, Shu-Sheng; Lee, Chih-Kung

    2013-02-01

    We developed a new metrology platform which can detect real-time changes in both a phase-interrogation mode and intensity mode of a SPR (surface plasmon resonance). We integrated a SPR and ellipsometer to a biosensor chip platform to create a new biomolecular interaction measurement mechanism. We adopted a conductive ITO (indium-tinoxide) film to the bio-sensor platform chip to expand the dynamic range and improve measurement accuracy. The thickness of the conductive film and the suitable voltage constants were found to enhance performance. A circularly polarized ellipsometry configuration was incorporated into the newly developed platform to measure the label-free interactions of recombinant human C-reactive protein (CRP) with immobilized biomolecule target monoclonal human CRP antibody at various concentrations. CRP was chosen as it is a cardiovascular risk biomarker and is an acute phase reactant as well as a specific prognostic indicator for inflammation. We found that the sensitivity of a phaseinterrogation SPR is predominantly dependent on the optimization of the sample incidence angle. The effect of the ITO layer effective index under DC and AC effects as well as an optimal modulation were experimentally performed and discussed. Our experimental results showed that the modulated dynamic range for phase detection was 10E-2 RIU based on a current effect and 10E-4 RIU based on a potential effect of which a 0.55 (°/RIU) measurement was found by angular-interrogation. The performance of our newly developed metrology platform was characterized to have a higher sensitivity and less dynamic range when compared to a traditional full-field measurement system.

  3. Genomics Portals: integrative web-platform for mining genomics data

    Directory of Open Access Journals (Sweden)

    Ghosh Krishnendu

    2010-01-01

    Full Text Available Abstract Background A large amount of experimental data generated by modern high-throughput technologies is available through various public repositories. Our knowledge about molecular interaction networks, functional biological pathways and transcriptional regulatory modules is rapidly expanding, and is being organized in lists of functionally related genes. Jointly, these two sources of information hold a tremendous potential for gaining new insights into functioning of living systems. Results Genomics Portals platform integrates access to an extensive knowledge base and a large database of human, mouse, and rat genomics data with basic analytical visualization tools. It provides the context for analyzing and interpreting new experimental data and the tool for effective mining of a large number of publicly available genomics datasets stored in the back-end databases. The uniqueness of this platform lies in the volume and the diversity of genomics data that can be accessed and analyzed (gene expression, ChIP-chip, ChIP-seq, epigenomics, computationally predicted binding sites, etc, and the integration with an extensive knowledge base that can be used in such analysis. Conclusion The integrated access to primary genomics data, functional knowledge and analytical tools makes Genomics Portals platform a unique tool for interpreting results of new genomics experiments and for mining the vast amount of data stored in the Genomics Portals backend databases. Genomics Portals can be accessed and used freely at http://GenomicsPortals.org.

  4. Fundamentals of power integrity for computer platforms and systems

    CERN Document Server

    DiBene, Joseph T

    2014-01-01

    An all-encompassing text that focuses on the fundamentals of power integrity Power integrity is the study of power distribution from the source to the load and the system level issues that can occur across it. For computer systems, these issues can range from inside the silicon to across the board and may egress into other parts of the platform, including thermal, EMI, and mechanical. With a focus on computer systems and silicon level power delivery, this book sheds light on the fundamentals of power integrity, utilizing the author's extensive background in the power integrity industry and un

  5. Exploration and implementation of ontology-based cultural relic knowledge map integration platform

    Science.gov (United States)

    Yang, Weiqiang; Dong, Yiqiang

    2018-05-01

    To help designers to better carry out creative design and improve the ability of searching traditional cultural relic information, the ontology-based knowledge map construction method was explored and an integrated platform for cultural relic knowledge map was developed. First of all, the construction method of the ontology of cultural relics was put forward, and the construction of the knowledge map of cultural relics was completed based on the constructed cultural relic otology. Then, a personalized semantic retrieval framework for creative design was proposed. Finally, the integrated platform of the knowledge map of cultural relics was designed and realized. The platform was divided into two parts. One was the foreground display system, which was used for designers to search and browse cultural relics. The other was the background management system, which was for cultural experts to manage cultural relics' knowledge. The research results showed that the platform designed could improve the retrieval ability of cultural relic information. To sum up, the platform can provide a good support for the designer's creative design.

  6. An Integrated Platform for Dynamic Software Updating and its Application in Self-* systems

    DEFF Research Database (Denmark)

    Gregersen, Allan Raundahl; Jørgensen, Bo Nørregaard; Hadaytullah

    2012-01-01

    Practical dynamic updating of modern Java applications requires tool support to become an integral part of the software development and maintenance lifecycle. In this paper we present Javeleon, an easy-to-use tool for dynamic updates of Java applications. To support integration with specific...... frameworks, component systems and application servers, Javeleon currently provides tight integration with the NetBeans Platform, facilitating dynamic updating for applications built on top of the NetBeans Platform in an unconstrained manner. Javeleon supports state-preserving unanticipated runtime evolution...

  7. A Platform for Mobile Service Provisioning Based on SOA-Integration

    Science.gov (United States)

    Decker, Michael; Bulander, Rebecca

    A middleware platform designed for the provisioning of data services for mobile computers using wireless data communication (e.g. smartphones or PDAs) has to offer a variety of different features. Some of these features have to be provided by external parties, e.g. billing or content syndication. The integration of all these features while considering mobile-specific challenges is a demanding task. In the article at hand we thus describe a middleware platform for mobile services which follows the idea of a so called Enterprise Service Bus (ESB). We explain the concept of ESB and argue why an ESB is an appropriate fundament for a platform for mobile service provisioning.

  8. Problems in mathematical analysis III integration

    CERN Document Server

    Kaczor, W J

    2003-01-01

    We learn by doing. We learn mathematics by doing problems. This is the third volume of Problems in Mathematical Analysis. The topic here is integration for real functions of one real variable. The first chapter is devoted to the Riemann and the Riemann-Stieltjes integrals. Chapter 2 deals with Lebesgue measure and integration. The authors include some famous, and some not so famous, integral inequalities related to Riemann integration. Many of the problems for Lebesgue integration concern convergence theorems and the interchange of limits and integrals. The book closes with a section on Fourier series, with a concentration on Fourier coefficients of functions from particular classes and on basic theorems for convergence of Fourier series. The book is primarily geared toward students in analysis, as a study aid, for problem-solving seminars, or for tutorials. It is also an excellent resource for instructors who wish to incorporate problems into their lectures. Solutions for the problems are provided in the boo...

  9. REopt: A Platform for Energy System Integration and Optimization: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Simpkins, T.; Cutler, D.; Anderson, K.; Olis, D.; Elgqvist, E.; Callahan, M.; Walker, A.

    2014-08-01

    REopt is NREL's energy planning platform offering concurrent, multi-technology integration and optimization capabilities to help clients meet their cost savings and energy performance goals. The REopt platform provides techno-economic decision-support analysis throughout the energy planning process, from agency-level screening and macro planning to project development to energy asset operation. REopt employs an integrated approach to optimizing a site?s energy costs by considering electricity and thermal consumption, resource availability, complex tariff structures including time-of-use, demand and sell-back rates, incentives, net-metering, and interconnection limits. Formulated as a mixed integer linear program, REopt recommends an optimally-sized mix of conventional and renewable energy, and energy storage technologies; estimates the net present value associated with implementing those technologies; and provides the cost-optimal dispatch strategy for operating them at maximum economic efficiency. The REopt platform can be customized to address a variety of energy optimization scenarios including policy, microgrid, and operational energy applications. This paper presents the REopt techno-economic model along with two examples of recently completed analysis projects.

  10. Offshore platform integration and floatover technology

    CERN Document Server

    Liu, Gengshen

    2017-01-01

    This book discusses offshore platform integration technology, focusing on the floatover methodology and its applications. It also addresses topics related to safety and cost-effectiveness, as well as ensuring the success of a project through careful planning and established detailed operation procedure/working manuals, which are rarely found in the published literature. Unlike other publications in this area, the book not only includes details of technology development, but also presents real project cases in the discussion to make it more comprehensible. Each topic is illustrated with carefully created sketches to show the complex operation procedures. .

  11. Using Docker Compose for the Simple Deployment of an Integrated Drug Target Screening Platform

    Directory of Open Access Journals (Sweden)

    List Markus

    2017-06-01

    Full Text Available Docker virtualization allows for software tools to be executed in an isolated and controlled environment referred to as a container. In Docker containers, dependencies are provided exactly as intended by the developer and, consequently, they simplify the distribution of scientific software and foster reproducible research. The Docker paradigm is that each container encapsulates one particular software tool. However, to analyze complex biomedical data sets, it is often necessary to combine several software tools into elaborate workflows. To address this challenge, several Docker containers need to be instantiated and properly integrated, which complicates the software deployment process unnecessarily. Here, we demonstrate how an extension to Docker, Docker compose, can be used to mitigate these problems by providing a unified setup routine that deploys several tools in an integrated fashion. We demonstrate the power of this approach by example of a Docker compose setup for a drug target screening platform consisting of five integrated web applications and shared infrastructure, deployable in just two lines of codes.

  12. Using Docker Compose for the Simple Deployment of an Integrated Drug Target Screening Platform.

    Science.gov (United States)

    List, Markus

    2017-06-10

    Docker virtualization allows for software tools to be executed in an isolated and controlled environment referred to as a container. In Docker containers, dependencies are provided exactly as intended by the developer and, consequently, they simplify the distribution of scientific software and foster reproducible research. The Docker paradigm is that each container encapsulates one particular software tool. However, to analyze complex biomedical data sets, it is often necessary to combine several software tools into elaborate workflows. To address this challenge, several Docker containers need to be instantiated and properly integrated, which complicates the software deployment process unnecessarily. Here, we demonstrate how an extension to Docker, Docker compose, can be used to mitigate these problems by providing a unified setup routine that deploys several tools in an integrated fashion. We demonstrate the power of this approach by example of a Docker compose setup for a drug target screening platform consisting of five integrated web applications and shared infrastructure, deployable in just two lines of codes.

  13. Wolfram technologies as an integrated scalable platform for interactive learning

    Science.gov (United States)

    Kaurov, Vitaliy

    2012-02-01

    We rely on technology profoundly with the prospect of even greater integration in the future. Well known challenges in education are a technology-inadequate curriculum and many software platforms that are difficult to scale or interconnect. We'll review an integrated technology, much of it free, that addresses these issues for individuals and small schools as well as for universities. Topics include: Mathematica, a programming environment that offers a diverse range of functionality; natural language programming for getting started quickly and accessing data from Wolfram|Alpha; quick and easy construction of interactive courseware and scientific applications; partnering with publishers to create interactive e-textbooks; course assistant apps for mobile platforms; the computable document format (CDF); teacher-student and student-student collaboration on interactive projects and web publishing at the Wolfram Demonstrations site.

  14. An integrated platform for assessing biologics (Conference Presentation)

    Science.gov (United States)

    Schein, Perry; O'Dell, Dakota; Erickson, David

    2016-04-01

    Protein therapeutics are a rapidly growing portion of the pharmaceuticals market and have many significant advantages over traditional small molecule drugs. As this market expands, however, critical regulatory and quality control issues remain, most notably the problem of protein aggregation. Individual target proteins often aggregate into larger masses which trigger an immune response in the body, which can reduce the efficacy of the drug for its intended purpose, or cause serious anaphylactic side-effects. Although detecting and minimizing aggregate formation is critical to ensure an effective product, aggregation dynamics are often highly complicated and there is little hope of reliable prediction and prevention from first principles. This problem is compounded for aggregates in the subvisible range of 100 nm to 10 micrometers where traditional techniques for detecting aggregates have significant limitations. Here, we present an integrated optofluidic platform for detecting nanoscale protein aggregates and characterizing interactions between these aggregates and a reference surface. By delivering light to a solution of proteins with an optical waveguide, scattered light from individual protein aggregates can be detected and analyzed to determine the force profile between each particle and the waveguide surface. Unlike existing methods which only determine size or charge, our label-free screening technique can directly measure the surface interaction forces between single aggregates and the glass substrate. This direct measurement capability may allow for better empirical predictions of the stability of protein aggregates during drug manufacturing and storage.

  15. Development and application of knowledge-based subject group integration platforms:A case study of Shanghai Institute of Ceramics,CAS

    Institute of Scientific and Technical Information of China (English)

    Yu; LIU; Jian; FU; Huijun; ZHENG; Hao; CHEN; Zhiping; YANG

    2014-01-01

    Purpose:According to the different requirements of research group users,we established the knowledge-based subject group integration platforms of Shanghai Institute of Ceramics,the Chinese Academy of Sciences(abbreviated as SIC CAS hereinafter),which were designed and constructed to better meet the needs of CAS research groups for their development,collaboration and communication.Design/methodology/approach:We first identified the requirements of users via preliminary investigation,and then chose CASI1 P,iLibrary and XKE technology,respectively as the building tools compatible with the major demands of users.These steps helped us complete the layout design of SIC CAS integration platforms,as well as its knowledge organization and integration.Findings:According to the need of users,we applied three types of platform construction technologies to five SIC integration platforms,and formulated standard norms for the further construction process,which could provide useful reference for a sustainable development for the extensive construction in CAS institutes.Research limitations:In order to make the SIC integration platforms more intelligent and have more functions,we need to enlarge the scale of the Platforms and upgrade the building tools for the platform construction.Practical implications:The nature of SIC sub-project integration platforms is to construct a content-sensitive environment which can embed knowledge services and knowledge applications seamlessly into scientific activities,so the Platform is expected to be a useful tool to help researchers better understand the recent development of the research field and form collaborations with their peers.Originality/value:SIC integration platforms are the only pilot construction that used 3different platform technologies in the first batch of knowledge-based subject group integration platforms of the Chinese Academy of Sciences.The construction is user-centered throughout the whole process,namely,from the technology

  16. An Integrated System for Disabled People Developed with the Agent Platform PANGEA

    Directory of Open Access Journals (Sweden)

    Carolina ZATO

    2013-11-01

    Full Text Available New trends in multi-agent systems call for self-adaptation and high dynamics, hence the new model of open MAS or virtual organization of agents. However, as existing agent platforms are not yet equipped to support this behavior, it is necessary to create new systems and mechanisms to facilitate the development of these new architectures. This article presents PANGEA, an agent platform to develop open multi-agent systems, specifically those including organizational aspects such as virtual agent organizations. The platform allows the integral management of organizations and offers tools to the end user. Additionally, it includes a communication protocol based on the IRC standard, which facilitates implementation and remains robust even with a large number of connections. The introduction of a CommunicationAgent and a Sniffer make it possible to offer Web Services for the distributed control of interaction. In order to test PANGEA, an integral system was developed to help the disabled, gathering a set of easily deployable and integrated services under a single architecture.

  17. Biomass Program 2007 Peer Review - Integrated Biorefinery Platform Summary

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2009-10-27

    This document discloses the comments provided by a review panel at the U.S. Department of Energy Office of the Biomass Program Peer Review held on November 15-16, 2007 in Baltimore, MD and the Integrated Biorefinery Platform Review held on August 13-15, 2007 in Golden, Colorado.

  18. IVSPlat 1.0: an integrated virtual screening platform with a molecular graphical interface.

    Science.gov (United States)

    Sun, Yin Xue; Huang, Yan Xin; Li, Feng Li; Wang, Hong Yan; Fan, Cong; Bao, Yong Li; Sun, Lu Guo; Ma, Zhi Qiang; Kong, Jun; Li, Yu Xin

    2012-01-05

    The virtual screening (VS) of lead compounds using molecular docking and pharmacophore detection is now an important tool in drug discovery. VS tasks typically require a combination of several software tools and a molecular graphics system. Thus, the integration of all the requisite tools in a single operating environment could reduce the complexity of running VS experiments. However, only a few freely available integrated software platforms have been developed. A free open-source platform, IVSPlat 1.0, was developed in this study for the management and automation of VS tasks. We integrated several VS-related programs into a molecular graphics system to provide a comprehensive platform for the solution of VS tasks based on molecular docking, pharmacophore detection, and a combination of both methods. This tool can be used to visualize intermediate and final results of the VS execution, while also providing a clustering tool for the analysis of VS results. A case study was conducted to demonstrate the applicability of this platform. IVSPlat 1.0 provides a plug-in-based solution for the management, automation, and visualization of VS tasks. IVSPlat 1.0 is an open framework that allows the integration of extra software to extend its functionality and modified versions can be freely distributed. The open source code and documentation are available at http://kyc.nenu.edu.cn/IVSPlat/.

  19. Fully integrated biochip platforms for advanced healthcare.

    Science.gov (United States)

    Carrara, Sandro; Ghoreishizadeh, Sara; Olivo, Jacopo; Taurino, Irene; Baj-Rossi, Camilla; Cavallini, Andrea; de Beeck, Maaike Op; Dehollain, Catherine; Burleson, Wayne; Moussy, Francis Gabriel; Guiseppi-Elie, Anthony; De Micheli, Giovanni

    2012-01-01

    Recent advances in microelectronics and biosensors are enabling developments of innovative biochips for advanced healthcare by providing fully integrated platforms for continuous monitoring of a large set of human disease biomarkers. Continuous monitoring of several human metabolites can be addressed by using fully integrated and minimally invasive devices located in the sub-cutis, typically in the peritoneal region. This extends the techniques of continuous monitoring of glucose currently being pursued with diabetic patients. However, several issues have to be considered in order to succeed in developing fully integrated and minimally invasive implantable devices. These innovative devices require a high-degree of integration, minimal invasive surgery, long-term biocompatibility, security and privacy in data transmission, high reliability, high reproducibility, high specificity, low detection limit and high sensitivity. Recent advances in the field have already proposed possible solutions for several of these issues. The aim of the present paper is to present a broad spectrum of recent results and to propose future directions of development in order to obtain fully implantable systems for the continuous monitoring of the human metabolism in advanced healthcare applications.

  20. Participatory Planning, Monitoring and Evaluation of Multi-Stakeholder Platforms in Integrated Landscape Initiatives.

    Science.gov (United States)

    Kusters, Koen; Buck, Louise; de Graaf, Maartje; Minang, Peter; van Oosten, Cora; Zagt, Roderick

    2017-03-21

    Integrated landscape initiatives typically aim to strengthen landscape governance by developing and facilitating multi-stakeholder platforms. These are institutional coordination mechanisms that enable discussions, negotiations, and joint planning between stakeholders from various sectors in a given landscape. Multi-stakeholder platforms tend to involve complex processes with diverse actors, whose objectives and focus may be subjected to periodic re-evaluation, revision or reform. In this article we propose a participatory method to aid planning, monitoring, and evaluation of such platforms, and we report on experiences from piloting the method in Ghana and Indonesia. The method is comprised of three components. The first can be used to look ahead, identifying priorities for future multi-stakeholder collaboration in the landscape. It is based on the identification of four aspirations that are common across multi-stakeholder platforms in integrated landscape initiatives. The second can be used to look inward. It focuses on the processes within an existing multi-stakeholder platform in order to identify areas for possible improvement. The third can be used to look back, identifying the main outcomes of an existing platform and comparing them to the original objectives. The three components can be implemented together or separately. They can be used to inform planning and adaptive management of the platform, as well as to demonstrate performance and inform the design of new interventions.

  1. A service platform architecture design towards a light integration of heterogeneous systems in the wellbeing domain.

    Science.gov (United States)

    Yang, Yaojin; Ahtinen, Aino; Lahteenmaki, Jaakko; Nyman, Petri; Paajanen, Henrik; Peltoniemi, Teijo; Quiroz, Carlos

    2007-01-01

    System integration is one of the major challenges for building wellbeing or healthcare related information systems. In this paper, we are going to share our experiences on how to design a service platform called Nuadu service platform, for providing integrated services in occupational health promotion and health risk management through two heterogeneous systems. Our design aims for a light integration covering the layers, from data through service up to presentation, while maintaining the integrity of the underlying systems.

  2. Solution of direct kinematic problem for Stewart-Gough platform with the use of analytical equation of plane

    Directory of Open Access Journals (Sweden)

    A. L. Lapikov

    2014-01-01

    Full Text Available The paper concerns the solution of direct kinematic problem for the Stewart-Gough platform of the type 6-3. The article represents a detailed analysis of methods of direct kinematic problem solution for platform mechanisms based on the parallel structures. The complexity of the problem solution is estimated for the mechanisms of parallel kinematics in comparison with the classic manipulators, characterized by the open kinematic chain.The method for the solution of this problem is suggested. It consists in setting up the correspondence between the functional dependence of Cartesian coordinates and the orientation of the moving platform centre on the values of generalized coordinates of the manipulator, which may be represented, in the case of platform manipulators, by the lengths of extensible arms to connect the foundation and the moving platform of the manipulator. The method is constructed in such a way that the solution of the direct kinematic problem reduces to solution of the analytical equation of plane where the moving platform is situated. The equation of the required plane is built according to three points which in this case are attachment points of moving platform joints. To define joints coordinates values it is necessary to generate a system of nine nonlinear equations. It ought to be noted that in generating a system of equation are used the equations with the same type of nonlinearity. The physical meaning of all nine equations of the system is Euclidean distance between the points of the manipulator. The location and orientation of the moving platform is represented as a homogeneous transformation matrix. The components of translation and rotation of this matrix can be defined through the required plane.The obtained theoretical results are supposed to be used in the decision support system during the complex research of multi-sectional manipulators of parallel kinematics to describe the geometrically similar 3D-prototype of the

  3. The Role of Semantics in Open-World, Integrative, Collaborative Science Data Platforms

    Science.gov (United States)

    Fox, Peter; Chen, Yanning; Wang, Han; West, Patrick; Erickson, John; Ma, Marshall

    2014-05-01

    As collaborative science spreads into more and more Earth and space science fields, both participants and funders are expressing stronger needs for highly functional data and information capabilities. Characteristics include a) easy to use, b) highly integrated, c) leverage investments, d) accommodate rapid technical change, and e) do not incur undue expense or time to build or maintain - these are not a small set of requirements. Based on our accumulated experience over the last ~ decade and several key technical approaches, we adapt, extend, and integrate several open source applications and frameworks to handle major portions of functionality for these platforms. This includes: an object-type repository, collaboration tools, identity management, all within a portal managing diverse content and applications. In this contribution, we present our methods and results of information models, adaptation, integration and evolution of a networked data science architecture based on several open source technologies (Drupal, VIVO, the Comprehensive Knowledge Archive Network; CKAN, and the Global Handle System; GHS). In particular we present the Deep Carbon Observatory - a platform for international science collaboration. We present and discuss key functional and non-functional attributes, and discuss the general applicability of the platform.

  4. Integration of the program TNXYZ in the platform SALOME

    International Nuclear Information System (INIS)

    Chaparro V, F. J.; Silva A, L.; Del Valle G, E.; Gomez T, A. M.; Vargas E, S.

    2013-10-01

    This work presents the procedure realized to integrate the code TNXYZ like a processing tool to the graphic simulation platform SALOME. The code TNXYZ solves the neutron transport equation in stationary state, for several energy groups, quantizing the angular variable by the discrete ordinates method and the space variable by nodal methods. The platform SALOME is a graphic surrounding designed for the construction, edition and simulation of mechanical models focused to the industry and contrary to other software, it allows to integrate external source codes to the surrounding, to form a complete scheme of execution, supervision, pre and post information processing. The code TNXYZ was programmed in the 90s in a Fortran compiler, but to be used at the present time the code should be actualized to the current compiler characteristics; also, in the original scheme was carried out a modularization process, that is to say, the main program was divided in sections where the code carries out important operations, with the intention of flexibility the data extraction process along its processing sequence and that can be useful in a later development of coupling. Finally, to verify the integration a fuel assembly BWR was modeled, as well as a control cell. The cross sections were obtained with the Monte Carlo Serpent code. Some results obtained with Serpent were used to verify and to begin with the validation of the code, being obtained an acceptable comparison in the infinite multiplication factor. The validation process should extend and one has planned to present in a future work. This work is part of the development of the research group formed between the Escuela Superior de Fisica y Matematicas del Instituto Politecnico Nacional (IPN) and the Instituto Nacional de Investigaciones Nucleares (ININ) in which a simulation Mexican platform of nuclear reactors is developed. (Author)

  5. Fully Integrated Biochip Platforms for Advanced Healthcare

    Directory of Open Access Journals (Sweden)

    Giovanni De Micheli

    2012-08-01

    Full Text Available Recent advances in microelectronics and biosensors are enabling developments of innovative biochips for advanced healthcare by providing fully integrated platforms for continuous monitoring of a large set of human disease biomarkers. Continuous monitoring of several human metabolites can be addressed by using fully integrated and minimally invasive devices located in the sub-cutis, typically in the peritoneal region. This extends the techniques of continuous monitoring of glucose currently being pursued with diabetic patients. However, several issues have to be considered in order to succeed in developing fully integrated and minimally invasive implantable devices. These innovative devices require a high-degree of integration, minimal invasive surgery, long-term biocompatibility, security and privacy in data transmission, high reliability, high reproducibility, high specificity, low detection limit and high sensitivity. Recent advances in the field have already proposed possible solutions for several of these issues. The aim of the present paper is to present a broad spectrum of recent results and to propose future directions of development in order to obtain fully implantable systems for the continuous monitoring of the human metabolism in advanced healthcare applications.

  6. Design and Development of ChemInfoCloud: An Integrated Cloud Enabled Platform for Virtual Screening.

    Science.gov (United States)

    Karthikeyan, Muthukumarasamy; Pandit, Deepak; Bhavasar, Arvind; Vyas, Renu

    2015-01-01

    The power of cloud computing and distributed computing has been harnessed to handle vast and heterogeneous data required to be processed in any virtual screening protocol. A cloud computing platorm ChemInfoCloud was built and integrated with several chemoinformatics and bioinformatics tools. The robust engine performs the core chemoinformatics tasks of lead generation, lead optimisation and property prediction in a fast and efficient manner. It has also been provided with some of the bioinformatics functionalities including sequence alignment, active site pose prediction and protein ligand docking. Text mining, NMR chemical shift (1H, 13C) prediction and reaction fingerprint generation modules for efficient lead discovery are also implemented in this platform. We have developed an integrated problem solving cloud environment for virtual screening studies that also provides workflow management, better usability and interaction with end users using container based virtualization, OpenVz.

  7. SALOME. A software integration platform for multi-physics, pre-processing and visualisation

    International Nuclear Information System (INIS)

    Bergeaud, Vincent; Lefebvre, Vincent

    2010-01-01

    In order to ease the development of applications integrating simulation codes, CAD modelers and post-processing tools. CEA and EDF R and D have invested in the SALOME platform, a tool dedicated to the environment of the scientific codes. The platform comes in the shape of a toolbox which offers functionalities for CAD, meshing, code coupling, visualization, GUI development. These tools can be combined to create integrated applications that make the scientific codes easier to use and well-interfaced with their environment be it other codes, CAD and meshing tools or visualization software. Many projects in CEA and EDF R and D now use SALOME, bringing technical coherence to the software suites of our institutions. (author)

  8. Integrating cell on chip—Novel waveguide platform employing ultra-long optical paths

    Directory of Open Access Journals (Sweden)

    Lena Simone Fohrmann

    2017-09-01

    Full Text Available Optical waveguides are the most fundamental building blocks of integrated optical circuits. They are extremely well understood, yet there is still room for surprises. Here, we introduce a novel 2D waveguide platform which affords a strong interaction of the evanescent tail of a guided optical wave with an external medium while only employing a very small geometrical footprint. The key feature of the platform is its ability to integrate the ultra-long path lengths by combining low propagation losses in a silicon slab with multiple reflections of the guided wave from photonic crystal (PhC mirrors. With a reflectivity of 99.1% of our tailored PhC-mirrors, we achieve interaction paths of 25 cm within an area of less than 10 mm2. This corresponds to 0.17 dB/cm effective propagation which is much lower than the state-of-the-art loss of approximately 1 dB/cm of single mode silicon channel waveguides. In contrast to conventional waveguides, our 2D-approach leads to a decay of the guided wave power only inversely proportional to the optical path length. This entirely different characteristic is the major advantage of the 2D integrating cell waveguide platform over the conventional channel waveguide concepts that obey the Beer-Lambert law.

  9. Integrating cell on chip—Novel waveguide platform employing ultra-long optical paths

    Science.gov (United States)

    Fohrmann, Lena Simone; Sommer, Gerrit; Pitruzzello, Giampaolo; Krauss, Thomas F.; Petrov, Alexander Yu.; Eich, Manfred

    2017-09-01

    Optical waveguides are the most fundamental building blocks of integrated optical circuits. They are extremely well understood, yet there is still room for surprises. Here, we introduce a novel 2D waveguide platform which affords a strong interaction of the evanescent tail of a guided optical wave with an external medium while only employing a very small geometrical footprint. The key feature of the platform is its ability to integrate the ultra-long path lengths by combining low propagation losses in a silicon slab with multiple reflections of the guided wave from photonic crystal (PhC) mirrors. With a reflectivity of 99.1% of our tailored PhC-mirrors, we achieve interaction paths of 25 cm within an area of less than 10 mm2. This corresponds to 0.17 dB/cm effective propagation which is much lower than the state-of-the-art loss of approximately 1 dB/cm of single mode silicon channel waveguides. In contrast to conventional waveguides, our 2D-approach leads to a decay of the guided wave power only inversely proportional to the optical path length. This entirely different characteristic is the major advantage of the 2D integrating cell waveguide platform over the conventional channel waveguide concepts that obey the Beer-Lambert law.

  10. Integration of Fractal Biosensor in a Digital Microfluidic Platform

    KAUST Repository

    Mashraei, Yousof

    2016-06-08

    The digital microfluidic (DMF) platform introduces many applications in biomedical assays. If it is to be commercially available to the public, it needs to have the essential features of smart sensing and a compact size. In this work, we report on a fractal electrode biosensor that is used for both droplet actuation and sensing C-reactive protein (CRP) concentration levels to assess cardiac disease risk. Our proposed electrode is the first two-terminal electrode design to be integrated into DMF platforms. A simulation of the electrical field distribution shows reduced peak intensities and uniform distribution of the field. When compared to a V-notch square electrode, the fractal electrode shows a superior performance in both aspects, i.e. field uniformity and intensity. These improvements are translated into a successful and responsive actuation of a water droplet with 100V. Likewise, the effective dielectric strength is improved by a 33% increase in the fractal electrode breakdown voltage. Additionally, the capability of the fractal electrode to work as a capacitive biosensor is evaluated with CRP quantification test. Selected fractal electrodes undergo a surface treatment to immobilize anti-CRP antibodies on their surface. The measurement shows a response to the added CRP in capacitance within three minutes. When the untreated electrodes were used for quantification, there was no significant change in capacitance, and this suggested that immobilization was necessary. The electrodes configuration in the fabricated DMF platform allows the fractal electrodes to be selectively used as biosensors, which means the device could be integrated into point-of-care applications.

  11. From NHS Choices to the integrated customer service platform.

    Science.gov (United States)

    Gann, Bob; Grant, Maria J

    2013-03-01

    In 2013 the NHS Commissioning Board launches its new integrated customer service platform. The new service utilises the full range of channels (web, telephone, apps etc) to provide access to information to support transparency, participation and transactions. Digital health services have proven benefits in informed choice, shared decision making and patient participation. © 2013 The authors. Health Information and Libraries Journal © 2013 Health Libraries Group.

  12. Thermo-economic assessment of the integration of steam cycles on offshore platforms

    DEFF Research Database (Denmark)

    Nguyen, Tuong-Van; Tock, Laurence; Breuhaus, Peter

    2014-01-01

    thermodynamic and economic performance indicators. The results illustrate the benefits of converting the gas turbines into a combined cycle. Using seawater results in smaller power generation and greater CO2-emissions than using process water, as the additional power generation in the combined cycle......The integration of steam bottoming cycles on oil platforms is often seen as a possible route to mitigate the CO2-emissions offshore. In this paper, a North Sea platform and its energy requirements are systematically analysed. The site-scale integration of steam networks is assessed by using...... is compensated by the significant pumping demand. This work emphasises that energy improvement efforts should be analysed at the scale of the overall site and not solely at the level of the combined cycle....

  13. Non-integrability of the Anisotropic Stormer Problem and the Isosceles Three-Body Problem

    Science.gov (United States)

    Nomikos, D. G.; Papageorgiou, V. G.

    2009-02-01

    We study the Anisotropic Stormer Problem (ASP) and the Isosceles Three-Body Problem (IP), from the viewpoint of integrability, using Morales-Ramis theory and its generalization. The study of their integrability presents particular interest since they model important physical phenomena. Both problems can be reduced with respect to the S1 symmetry. Almeida and Stuchi [M.A. Almeida, T.J. Stuchi, Non-integrability of the anisotropic Stormer problem with angular momentum, Physica D 189 (2004) 219-233] proved that the reduced ASP is non-integrable for almost all values of the parameters. In this paper we establish the non-integrability (in the extended Liouville sense) of the remaining cases. The IP is a special case of the three-body problem and it can be considered as a generalization of the Sitnikov problem. Here we prove that the complexified reduced IP does not admit an additional independent meromorphic first integral.

  14. Wafer-scale integrated micro-supercapacitors on an ultrathin and highly flexible biomedical platform.

    Science.gov (United States)

    Maeng, Jimin; Meng, Chuizhou; Irazoqui, Pedro P

    2015-02-01

    We present wafer-scale integrated micro-supercapacitors on an ultrathin and highly flexible parylene platform, as progress toward sustainably powering biomedical microsystems suitable for implantable and wearable applications. All-solid-state, low-profile (supercapacitors are formed on an ultrathin (~20 μm) freestanding parylene film by a wafer-scale parylene packaging process in combination with a polyaniline (PANI) nanowire growth technique assisted by surface plasma treatment. These micro-supercapacitors are highly flexible and shown to be resilient toward flexural stress. Further, direct integration of micro-supercapacitors into a radio frequency (RF) rectifying circuit is achieved on a single parylene platform, yielding a complete RF energy harvesting microsystem. The system discharging rate is shown to improve by ~17 times in the presence of the integrated micro-supercapacitors. This result suggests that the integrated micro-supercapacitor technology described herein is a promising strategy for sustainably powering biomedical microsystems dedicated to implantable and wearable applications.

  15. Study on concept of web-based reactor piping design data platform

    International Nuclear Information System (INIS)

    Wang Yu; Zhou Yu; Dong Jianling; Meng Yang

    2005-01-01

    For solving the piping design problems such as design data deficiency, designer communication inconvenience and design project inconsistence, Reactor Piping Design Database Platform, which is the main part of the Integrated Nuclear Project Research Platform, is proposed by analyzing the nuclear piping designs in detail. The functions and system structures of the platform are described in the paper for the sake of the realization of the Reactor Piping Design Database Platform. The platform is constituted by web-based management interface, AutoPlant selected as CAD software, and relation database management system (DBMS). (authors)

  16. Multi-octave spectral beam combiner on ultra-broadband photonic integrated circuit platform.

    Science.gov (United States)

    Stanton, Eric J; Heck, Martijn J R; Bovington, Jock; Spott, Alexander; Bowers, John E

    2015-05-04

    We present the design of a novel platform that is able to combine optical frequency bands spanning 4.2 octaves from ultraviolet to mid-wave infrared into a single, low M2 output waveguide. We present the design and realization of a key component in this platform that combines the wavelength bands of 350 nm - 1500 nm and 1500 nm - 6500 nm with demonstrated efficiency greater than 90% in near-infrared and mid-wave infrared. The multi-octave spectral beam combiner concept is realized using an integrated platform with silicon nitride waveguides and silicon waveguides. Simulated bandwidth is shown to be over four octaves, and measured bandwidth is shown over two octaves, limited by the availability of sources.

  17. Lagrangian Differentiation, Integration and Eigenvalues Problems

    International Nuclear Information System (INIS)

    Durand, L.

    1983-01-01

    Calogero recently proposed a new and very powerful method for the solution of Sturm-Liouville eigenvalue problems based on Lagrangian differentiation. In this paper, some results of a numerical investigation of Calogero's method for physical interesting problems are presented. It is then shown that one can 'invert' his differentiation technique to obtain a flexible, factorially convergent Lagrangian integration scheme which should be useful in a variety of problems, e.g. solution of integral equations

  18. Integrative set enrichment testing for multiple omics platforms

    Directory of Open Access Journals (Sweden)

    Poisson Laila M

    2011-11-01

    Full Text Available Abstract Background Enrichment testing assesses the overall evidence of differential expression behavior of the elements within a defined set. When we have measured many molecular aspects, e.g. gene expression, metabolites, proteins, it is desirable to assess their differential tendencies jointly across platforms using an integrated set enrichment test. In this work we explore the properties of several methods for performing a combined enrichment test using gene expression and metabolomics as the motivating platforms. Results Using two simulation models we explored the properties of several enrichment methods including two novel methods: the logistic regression 2-degree of freedom Wald test and the 2-dimensional permutation p-value for the sum-of-squared statistics test. In relation to their univariate counterparts we find that the joint tests can improve our ability to detect results that are marginal univariately. We also find that joint tests improve the ranking of associated pathways compared to their univariate counterparts. However, there is a risk of Type I error inflation with some methods and self-contained methods lose specificity when the sets are not representative of underlying association. Conclusions In this work we show that consideration of data from multiple platforms, in conjunction with summarization via a priori pathway information, leads to increased power in detection of genomic associations with phenotypes.

  19. Photonic integration and photonics-electronics convergence on silicon platform

    CERN Document Server

    Liu, Jifeng; Baba, Toshihiko; Vivien, Laurent; Xu, Dan-Xia

    2015-01-01

    Silicon photonics technology, which has the DNA of silicon electronics technology, promises to provide a compact photonic integration platform with high integration density, mass-producibility, and excellent cost performance. This technology has been used to develop and to integrate various photonic functions on silicon substrate. Moreover, photonics-electronics convergence based on silicon substrate is now being pursued. Thanks to these features, silicon photonics will have the potential to be a superior technology used in the construction of energy-efficient cost-effective apparatuses for various applications, such as communications, information processing, and sensing. Considering the material characteristics of silicon and difficulties in microfabrication technology, however, silicon by itself is not necessarily an ideal material. For example, silicon is not suitable for light emitting devices because it is an indirect transition material. The resolution and dynamic range of silicon-based interference de...

  20. The Real-Time Monitoring Service Platform for Land Supervision Based on Cloud Integration

    Science.gov (United States)

    Sun, J.; Mao, M.; Xiang, H.; Wang, G.; Liang, Y.

    2018-04-01

    Remote sensing monitoring has become the important means for land and resources departments to strengthen supervision. Aiming at the problems of low monitoring frequency and poor data currency in current remote sensing monitoring, this paper researched and developed the cloud-integrated real-time monitoring service platform for land supervision which enhanced the monitoring frequency by acquiring the domestic satellite image data overall and accelerated the remote sensing image data processing efficiency by exploiting the intelligent dynamic processing technology of multi-source images. Through the pilot application in Jinan Bureau of State Land Supervision, it has been proved that the real-time monitoring technical method for land supervision is feasible. In addition, the functions of real-time monitoring and early warning are carried out on illegal land use, permanent basic farmland protection and boundary breakthrough in urban development. The application has achieved remarkable results.

  1. Integrating LPR with CCTV systems: problems and solutions

    Science.gov (United States)

    Bissessar, David; Gorodnichy, Dmitry O.

    2011-06-01

    A new generation of high-resolution surveillance cameras makes it possible to apply video processing and recognition techniques on live video feeds for the purpose of automatically detecting and identifying objects and events of interest. This paper addresses a particular application of detecting and identifying vehicles passing through a checkpoint. This application is of interest to border services agencies and is also related to many other applications. With many commercial automated License Plate Recognition (LPR) systems available on the market, some of which are available as a plug-in for surveillance systems, this application still poses many unresolved technological challenges, the main two of which are: i) multiple and often noisy license plate readings generated for the same vehicle, and ii) failure to detect a vehicle or license plate altogether when the license plate is occluded or not visible. This paper presents a solution to both of these problems. A data fusion technique based on the Levenshtein distance is used to resolve the first problem. An integration of a commercial LPR system with the in-house built Video Analytic Platform is used to solve the latter. The developed solution has been tested in field environments and has been shown to yield a substantial improvement over standard off-the-shelf LPR systems.

  2. Framework programmable platform for the advanced software development workstation. Integration mechanism design document

    Science.gov (United States)

    Mayer, Richard J.; Blinn, Thomas M.; Mayer, Paula S. D.; Reddy, Uday; Ackley, Keith; Futrell, Mike

    1991-01-01

    The Framework Programmable Software Development Platform (FPP) is a project aimed at combining effective tool and data integration mechanisms with a model of the software development process in an intelligent integrated software development environment. Guided by this model, this system development framework will take advantage of an integrated operating environment to automate effectively the management of the software development process so that costly mistakes during the development phase can be eliminated.

  3. Approximate motion integrals and the quantum chaos problem

    International Nuclear Information System (INIS)

    Bunakov, V.E.; Ivanov, I.B.

    2001-01-01

    One discusses the problem of occurrence and seek for the motion integrals in the stationary quantum mechanics and its relation to the quantum chaos. One studies decomposition of quantum numbers and derives the criterion of chaos. To seek the motion integrals one applies the convergence method. One derived the approximate integrals in the Hennone-Hales problem. One discusses the problem of compatibility of chaos and integrability [ru

  4. National Bioenergy Center - Biochemical Platform Integration Project: Quarterly Update, Winter 2010

    Energy Technology Data Exchange (ETDEWEB)

    Schell, D.

    2011-02-01

    Winter 2011 edition of the National Bioenergy Center's Biochemical Platform Integration Project quarterly newsletter. Issue topics: 33rd Symposium on Biotechnology for Fuels and Chemicals program topic areas; results from reactive membrane extraction of inhibitors from dilute-acid pretreated corn stover; list of 2010 task publications.

  5. MATHEMATICAL PROBLEMS OF INTEGRATIVE CONTENTS

    Directory of Open Access Journals (Sweden)

    V. Kushnir

    2014-09-01

    Full Text Available The tasks of integrative content requires the use of knowledge and skills on various themes both one discipline and different disciplines. Mostly in the classroom (or in homework the tasks on the properties absorption of different concepts using different theories are considered. Thus knowledge within only one discipline is formed, knowledge of the narrow sense (one subject. Such knowledge is "prescriptional", we call it idealized. After all, it is far from models of the real professional problems and problems of life in general, in order to solve them it is necessary to apply knowledge and skills acquired in different themes of the same objects,life experience. Practical formation of integrative knowledge requires statement of the educational problems before the subjects of studying, the problems within the "narrow objectivity" can not be resolved at all, or such kind of solving is too difficult to solve, for example, the nature and the context of solving problems (scientific approaches to solving problems, creating mathematical models, methods for solving such models, means of solving, application of methods, analysis of the models solution and the right choice, the inspection of solutions, etc. will sink in the conglomeration of technical operations. The problems with integrative content are usually more complicated than the problems of "narrow objectivity." In our problems the index of such difficulty is the essence of educational content, which is disclosed in the previous paragraph. The problems solution proposed in this article requires knowledge of the structural geometry (circle construction, touching two or three laps: with analytic geometry (method of coordinates on the plane; the distance between two points on the coordinate plane; algebra (system drawing irrational equations, method for solving such system, the solution of the system, analysis of the results and the right choose of the desired solution for found criterion, testing

  6. Data exchange between zero dimensional code and physics platform in the CFETR integrated system code

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Guoliang [School of Nuclear Science and Technology, University of Science and Technology of China, Hefei 230026 China (China); Shi, Nan [Institute of Plasma Physics, Chinese Academy of Sciences, No. 350 Shushanhu Road, Hefei (China); Zhou, Yifu; Mao, Shifeng [School of Nuclear Science and Technology, University of Science and Technology of China, Hefei 230026 China (China); Jian, Xiang [State Key Laboratory of Advanced Electromagnetic Engineering and Technology, School of Electrical and Electronics Engineering, Huazhong University of Science and Technology, Wuhan 430074 (China); Chen, Jiale [Institute of Plasma Physics, Chinese Academy of Sciences, No. 350 Shushanhu Road, Hefei (China); Liu, Li; Chan, Vincent [School of Nuclear Science and Technology, University of Science and Technology of China, Hefei 230026 China (China); Ye, Minyou, E-mail: yemy@ustc.edu.cn [School of Nuclear Science and Technology, University of Science and Technology of China, Hefei 230026 China (China)

    2016-11-01

    Highlights: • The workflow of the zero dimensional code and the multi-dimension physics platform of CFETR integrated system codeis introduced. • The iteration process among the codes in the physics platform. • The data transfer between the zero dimensionalcode and the physical platform, including data iteration and validation, and justification for performance parameters.. - Abstract: The China Fusion Engineering Test Reactor (CFETR) integrated system code contains three parts: a zero dimensional code, a physics platform and an engineering platform. We use the zero dimensional code to identify a set of preliminary physics and engineering parameters for CFETR, which is used as input to initiate multi-dimension studies using the physics and engineering platform for design, verification and validation. Effective data exchange between the zero dimensional code and the physical platform is critical for the optimization of CFETR design. For example, in evaluating the impact of impurity radiation on core performance, an open field line code is used to calculate the impurity transport from the first-wall boundary to the pedestal. The impurity particle in the pedestal are used as boundary conditions in a transport code for calculating impurity transport in the core plasma and the impact of core radiation on core performance. Comparison of the results from the multi-dimensional study to those from the zero dimensional code is used to further refine the controlled radiation model. The data transfer between the zero dimensional code and the physical platform, including data iteration and validation, and justification for performance parameters will be presented in this paper.

  7. Analyzing composability of applications on MPSoC platforms

    NARCIS (Netherlands)

    Kumar, A.; Mesman, B.; Theelen, B.D.; Corporaal, H.; Yajun, H.

    2008-01-01

    Modern day applications require use of multi-processor systems for reasons of erformance, scalability and power efficiency. As more and more applications are integrated in a single system, mapping and analyzing them on a multi-processor platform becomes a multidimensional problem. Each possible set

  8. Design and control of multifunctional sorting and training platform based on PLC control

    Science.gov (United States)

    Wan, Hongqiang; Ge, Shuai; Han, Peiying; Li, Fancong; Zhang, Simiao

    2018-05-01

    Electromechanical integration, as a multi-disciplinary subject, has been paid much attention by universities and is widely used in the automation production of enterprises. Aiming at the problem of the lack of control among enterprises and the lack of training among colleges and universities, this paper presents a design of multifunctional sorting training platform based on PLC control. Firstly, the structure of the platform is determined and three-dimensional modeling is done. Then design the platform's aerodynamic control and electrical control. Finally, realize the platform sorting function through PLC programming and configuration software development. The training platform can be used to design the practical training experiment, which has a strong advance and pertinence in the electromechanical integration teaching. At the same time, the platform makes full use of modular thinking to make the sorting modules more flexible. Compared with the traditional training platform, its teaching effect is more significant.

  9. Towards a fully integrated indium-phosphide membrane on silicon photonics platform

    NARCIS (Netherlands)

    van Engelen, J.P.; Pogoretskiy, V.; Smit, M.K.; van der Tol, J.J.G.M.; Jiao, Y.

    2017-01-01

    Recently a uni-traveling-carrier photodetector with high speed (> 67GHz) and a high-gain optical amplifier (110/cm at 4 kA/cm2) have been demonstrated using the InP membrane-on-Silicon (IMOS) integration technology. Passives in IMOS have shown features comparable to SOI platforms due to the tight

  10. Integrated chemical sensor array platform based on a light emitting diode, xerogel-derived sensor elements, and high-speed pin printing

    International Nuclear Information System (INIS)

    Cho, Eun Jeong; Bright, Frank V.

    2002-01-01

    We report a new, solid-state, integrated optical array sensor platform. By using pin printing technology in concert with sol-gel-processing methods, we form discrete xerogel-based microsensor elements that are on the order of 100 μm in diameter and 1 μm thick directly on the face of a light emitting diode (LED). The LED serves as the light source to excite chemically responsive luminophores sequestered within the doped xerogel microsensors and the analyte-dependent emission from within the doped xerogel is detected with a charge coupled device (CCD). We overcome the problem of background illumination from the LED reaching the CCD and the associated biasing that results by coating the LED first with a thin layer of blue paint. The thin paint layer serves as an optical filter, knocking out the LEDs red-edge spectral tail. The problem of the spatially-dependent fluence across the LED face is solved entirely by performing ratiometric measurements. We illustrate the performance of the new sensor scheme by forming an array of 100 discrete O 2 -responsive sensing elements on the face of a single LED. The combination of pin printing with an integrated sensor and light source platform results in a rapid method of forming (∼1 s per sensor element) reusable sensor arrays. The entire sensor array can be calibrated using just one sensor element. Array-to-array reproducibly is <8%. Arrays can be formed using single or multiple pins with indistinguishable analytical performance

  11. Integrated platform and API for electrophysiological data.

    Science.gov (United States)

    Sobolev, Andrey; Stoewer, Adrian; Leonhardt, Aljoscha; Rautenberg, Philipp L; Kellner, Christian J; Garbers, Christian; Wachtler, Thomas

    2014-01-01

    Recent advancements in technology and methodology have led to growing amounts of increasingly complex neuroscience data recorded from various species, modalities, and levels of study. The rapid data growth has made efficient data access and flexible, machine-readable data annotation a crucial requisite for neuroscientists. Clear and consistent annotation and organization of data is not only an important ingredient for reproducibility of results and re-use of data, but also essential for collaborative research and data sharing. In particular, efficient data management and interoperability requires a unified approach that integrates data and metadata and provides a common way of accessing this information. In this paper we describe GNData, a data management platform for neurophysiological data. GNData provides a storage system based on a data representation that is suitable to organize data and metadata from any electrophysiological experiment, with a functionality exposed via a common application programming interface (API). Data representation and API structure are compatible with existing approaches for data and metadata representation in neurophysiology. The API implementation is based on the Representational State Transfer (REST) pattern, which enables data access integration in software applications and facilitates the development of tools that communicate with the service. Client libraries that interact with the API provide direct data access from computing environments like Matlab or Python, enabling integration of data management into the scientist's experimental or analysis routines.

  12. New integrable problems in a rigid body dynamics with cubic integral in velocities

    Science.gov (United States)

    Elmandouh, A. A.

    2018-03-01

    We introduce a new family of the 2D integrable mechanical system possessing an additional integral of the third degree in velocities. This system contains 20 arbitrary parameters. We also clarify that the majority of the previous systems with a cubic integral can be reconstructed from it as a special version for certain values of those parameters. The applications of this system are extended to include the problem of motion of a particle and rigid body about its fixed point. We announce new integrable problems describing the motion of a particle in the plane, pseudosphere, and surfaces of variable curvature. We also present a new integrable problem in a rigid body dynamics and this problem generalizes some of the previous results for Sokolov-Tsiganov, Yehia, Stretensky, and Goriachev.

  13. Booly: a new data integration platform

    Directory of Open Access Journals (Sweden)

    Karten Harvey J

    2010-10-01

    Full Text Available Abstract Background Data integration is an escalating problem in bioinformatics. We have developed a web tool and warehousing system, Booly, that features a simple yet flexible data model coupled with the ability to perform powerful comparative analysis, including the use of Boolean logic to merge datasets together, and an integrated aliasing system to decipher differing names of the same gene or protein. Furthermore, Booly features a collaborative sharing system and a public repository so that users can retrieve new datasets while contributors can easily disseminate new content. Results We illustrate the uses of Booly with several examples including: the versatile creation of homebrew datasets, the integration of heterogeneous data to identify genes useful for comparing avian and mammalian brain architecture, and generation of a list of Food and Drug Administration (FDA approved drugs with possible alternative disease targets. Conclusions The Booly paradigm for data storage and analysis should facilitate integration between disparate biological and medical fields and result in novel discoveries that can then be validated experimentally. Booly can be accessed at http://booly.ucsd.edu.

  14. a Workflow for UAV's Integration Into a Geodesign Platform

    Science.gov (United States)

    Anca, P.; Calugaru, A.; Alixandroae, I.; Nazarie, R.

    2016-06-01

    This paper presents a workflow for the development of various Geodesign scenarios. The subject is important in the context of identifying patterns and designing solutions for a Smart City with optimized public transportation, efficient buildings, efficient utilities, recreational facilities a.s.o.. The workflow describes the procedures starting with acquiring data in the field, data processing, orthophoto generation, DTM generation, integration into a GIS platform and analyzing for a better support for Geodesign. Esri's City Engine is used mostly for 3D modeling capabilities that enable the user to obtain 3D realistic models. The workflow uses as inputs information extracted from images acquired using UAVs technologies, namely eBee, existing 2D GIS geodatabases, and a set of CGA rules. The method that we used further, is called procedural modeling, and uses rules in order to extrude buildings, the street network, parcel zoning and side details, based on the initial attributes from the geodatabase. The resulted products are various scenarios for redesigning, for analyzing new exploitation sites. Finally, these scenarios can be published as interactive web scenes for internal, groups or pubic consultation. In this way, problems like the impact of new constructions being build, re-arranging green spaces or changing routes for public transportation, etc. are revealed through impact and visibility analysis or shadowing analysis and are brought to the citizen's attention. This leads to better decisions.

  15. Integrated Microfluidic Lectin Barcode Platform for High-Performance Focused Glycomic Profiling

    Science.gov (United States)

    Shang, Yuqin; Zeng, Yun; Zeng, Yong

    2016-02-01

    Protein glycosylation is one of the key processes that play essential roles in biological functions and dysfunctions. However, progress in glycomics has considerably lagged behind genomics and proteomics, due in part to the enormous challenges in analysis of glycans. Here we present a new integrated and automated microfluidic lectin barcode platform to substantially improve the performance of lectin array for focused glycomic profiling. The chip design and flow control were optimized to promote the lectin-glycan binding kinetics and speed of lectin microarray. Moreover, we established an on-chip lectin assay which employs a very simple blocking method to effectively suppress the undesired background due to lectin binding of antibodies. Using this technology, we demonstrated focused differential profiling of tissue-specific glycosylation changes of a biomarker, CA125 protein purified from ovarian cancer cell line and different tissues from ovarian cancer patients in a fast, reproducible, and high-throughput fashion. Highly sensitive CA125 detection was also demonstrated with a detection limit much lower than the clinical cutoff value for cancer diagnosis. This microfluidic platform holds the potential to integrate with sample preparation functions to construct a fully integrated “sample-to-answer” microsystem for focused differential glycomic analysis. Thus, our technology should present a powerful tool in support of rapid advance in glycobiology and glyco-biomarker development.

  16. Vertical integration of high-Q silicon nitride microresonators into silicon-on-insulator platform.

    Science.gov (United States)

    Li, Qing; Eftekhar, Ali A; Sodagar, Majid; Xia, Zhixuan; Atabaki, Amir H; Adibi, Ali

    2013-07-29

    We demonstrate a vertical integration of high-Q silicon nitride microresonators into the silicon-on-insulator platform for applications at the telecommunication wavelengths. Low-loss silicon nitride films with a thickness of 400 nm are successfully grown, enabling compact silicon nitride microresonators with ultra-high intrinsic Qs (~ 6 × 10(6) for 60 μm radius and ~ 2 × 10(7) for 240 μm radius). The coupling between the silicon nitride microresonator and the underneath silicon waveguide is based on evanescent coupling with silicon dioxide as buffer. Selective coupling to a desired radial mode of the silicon nitride microresonator is also achievable using a pulley coupling scheme. In this work, a 60-μm-radius silicon nitride microresonator has been successfully integrated into the silicon-on-insulator platform, showing a single-mode operation with an intrinsic Q of 2 × 10(6).

  17. Integrated Semantics Service Platform for the Internet of Things: A Case Study of a Smart Office

    Science.gov (United States)

    Ryu, Minwoo; Kim, Jaeho; Yun, Jaeseok

    2015-01-01

    The Internet of Things (IoT) allows machines and devices in the world to connect with each other and generate a huge amount of data, which has a great potential to provide useful knowledge across service domains. Combining the context of IoT with semantic technologies, we can build integrated semantic systems to support semantic interoperability. In this paper, we propose an integrated semantic service platform (ISSP) to support ontological models in various IoT-based service domains of a smart city. In particular, we address three main problems for providing integrated semantic services together with IoT systems: semantic discovery, dynamic semantic representation, and semantic data repository for IoT resources. To show the feasibility of the ISSP, we develop a prototype service for a smart office using the ISSP, which can provide a preset, personalized office environment by interpreting user text input via a smartphone. We also discuss a scenario to show how the ISSP-based method would help build a smart city, where services in each service domain can discover and exploit IoT resources that are wanted across domains. We expect that our method could eventually contribute to providing people in a smart city with more integrated, comprehensive services based on semantic interoperability. PMID:25608216

  18. Integrated Semantics Service Platform for the Internet of Things: A Case Study of a Smart Office

    Directory of Open Access Journals (Sweden)

    Minwoo Ryu

    2015-01-01

    Full Text Available The Internet of Things (IoT allows machines and devices in the world to connect with each other and generate a huge amount of data, which has a great potential to provide useful knowledge across service domains. Combining the context of IoT with semantic technologies, we can build integrated semantic systems to support semantic interoperability. In this paper, we propose an integrated semantic service platform (ISSP to support ontological models in various IoT-based service domains of a smart city. In particular, we address three main problems for providing integrated semantic services together with IoT systems: semantic discovery, dynamic semantic representation, and semantic data repository for IoT resources. To show the feasibility of the ISSP, we develop a prototype service for a smart office using the ISSP, which can provide a preset, personalized office environment by interpreting user text input via a smartphone. We also discuss a scenario to show how the ISSP-based method would help build a smart city, where services in each service domain can discover and exploit IoT resources that are wanted across domains. We expect that our method could eventually contribute to providing people in a smart city with more integrated, comprehensive services based on semantic interoperability.

  19. Integrated semantics service platform for the Internet of Things: a case study of a smart office.

    Science.gov (United States)

    Ryu, Minwoo; Kim, Jaeho; Yun, Jaeseok

    2015-01-19

    The Internet of Things (IoT) allows machines and devices in the world to connect with each other and generate a huge amount of data, which has a great potential to provide useful knowledge across service domains. Combining the context of IoT with semantic technologies, we can build integrated semantic systems to support semantic interoperability. In this paper, we propose an integrated semantic service platform (ISSP) to support ontological models in various IoT-based service domains of a smart city. In particular, we address three main problems for providing integrated semantic services together with IoT systems: semantic discovery, dynamic semantic representation, and semantic data repository for IoT resources. To show the feasibility of the ISSP, we develop a prototype service for a smart office using the ISSP, which can provide a preset, personalized office environment by interpreting user text input via a smartphone. We also discuss a scenario to show how the ISSP-based method would help build a smart city, where services in each service domain can discover and exploit IoT resources that are wanted across domains. We expect that our method could eventually contribute to providing people in a smart city with more integrated, comprehensive services based on semantic interoperability.

  20. Multi-fields' coordination information integrated platform for nuclear power plant operation preparation

    International Nuclear Information System (INIS)

    Yuan Chang; Li Yong; Ye Zhiqiang

    2011-01-01

    To realize the coordination in multi-fields' work and information sharing, by applying the method of Enterprise Architecture (EA), the business architecture, functional flow and application architecture of Nuclear Power Plant's operation preparation information integrated platform are designed, which can realize the information sharing and coordination of multi fields. (authors)

  1. Nucleic Acid-based Detection of Bacterial Pathogens Using Integrated Microfluidic Platform Systems

    Directory of Open Access Journals (Sweden)

    Carl A. Batt

    2009-05-01

    Full Text Available The advent of nucleic acid-based pathogen detection methods offers increased sensitivity and specificity over traditional microbiological techniques, driving the development of portable, integrated biosensors. The miniaturization and automation of integrated detection systems presents a significant advantage for rapid, portable field-based testing. In this review, we highlight current developments and directions in nucleic acid-based micro total analysis systems for the detection of bacterial pathogens. Recent progress in the miniaturization of microfluidic processing steps for cell capture, DNA extraction and purification, polymerase chain reaction, and product detection are detailed. Discussions include strategies and challenges for implementation of an integrated portable platform.

  2. An Optimal Strategic Business Model for Small Businesses Using Online Platforms

    Directory of Open Access Journals (Sweden)

    Hana Kim

    2018-02-01

    Full Text Available As ecommerce continues to grow, small businesses are using a variety of platforms to secure potential consumers. However, it is important for small business owners to choose an efficient business model because of constraints such as technical problems. In this study, based on platform characteristics we divide online shopping platforms into different types as follows: (1 information brokerage services; (2 online malls; and (3 omni-channel platforms. The efficiency of each group is measured by stochastic frontier analysis, and the efficiency comparison between the groups is made using meta-frontier analysis. As a result of the study, it is found that the efficiency of small business owners increases as functional integration increases, satisfying utilitarian motivations. However, a platform with greater integration that has a social presence satisfying hedonic motivations improves the efficiency of all small businesses using the platform instead of just the efficiency of a marginal number of small business owners. This study, based on the dynamic capabilities viewpoint, suggests that the omni-channel platform represents the most sustainable approach for small business owners undergoing difficulties such as technological and organizational changes.

  3. Integrated Tourism E-Commerce Platform for Scenery Administration Bureau, Travel Agency and Tourist

    Science.gov (United States)

    Liang, Zhixue; Wang, Shui

    Collaboration among multiple travel agencies and with scenery administration bureaus is vital for small or medium sized travel companies to succeed in the fierce competition of the tourism industry; business processes such as regrouping individual travelers between different agencies prove to be difficult and unpleasant user experience; tourists want to be more informed and have more initiative. To address these issues, proposes an integrated tourism e-commerce platform for travel agencies and scenery administration bureaus as well as tourists to interact in a more smooth way; this platform is constructed upon J2EE framework, provides online collaboration & coordination for companies and information services (such as self-navigation using Google Map etc) for tourists. A running implementation of this platform has been put into real business for a small travel company.

  4. Low-loss compact multilayer silicon nitride platform for 3D photonic integrated circuits.

    Science.gov (United States)

    Shang, Kuanping; Pathak, Shibnath; Guan, Binbin; Liu, Guangyao; Yoo, S J B

    2015-08-10

    We design, fabricate, and demonstrate a silicon nitride (Si(3)N(4)) multilayer platform optimized for low-loss and compact multilayer photonic integrated circuits. The designed platform, with 200 nm thick waveguide core and 700 nm interlayer gap, is compatible for active thermal tuning and applicable to realizing compact photonic devices such as arrayed waveguide gratings (AWGs). We achieve ultra-low loss vertical couplers with 0.01 dB coupling loss, multilayer crossing loss of 0.167 dB at 90° crossing angle, 50 μm bending radius, 100 × 2 μm(2) footprint, lateral misalignment tolerance up to 400 nm, and less than -52 dB interlayer crosstalk at 1550 nm wavelength. Based on the designed platform, we demonstrate a 27 × 32 × 2 multilayer star coupler.

  5. The business impact of an integrated continuous biomanufacturing platform for recombinant protein production.

    Science.gov (United States)

    Walther, Jason; Godawat, Rahul; Hwang, Chris; Abe, Yuki; Sinclair, Andrew; Konstantinov, Konstantin

    2015-11-10

    The biotechnology industry primarily uses batch technologies to manufacture recombinant proteins. The natural evolution of other industries has shown that transitioning from batch to continuous processing can yield significant benefits. A quantitative understanding of these benefits is critical to guide the implementation of continuous processing. In this manuscript, we use process economic modeling and Monte Carlo simulations to evaluate an integrated continuous biomanufacturing (ICB) platform and conduct risk-based valuation to generate a probabilistic range of net-present values (NPVs). For a specific ten-year product portfolio, the ICB platform reduces average cost by 55% compared to conventional batch processing, considering both capital and operating expenses. The model predicts that these savings can further increase by an additional 25% in situations with higher-than-expected product demand showing the upward potential of the ICB platform. The ICB platform achieves these savings and corresponding flexibility mainly due to process intensification in both upstream and downstream unit operations. This study demonstrates the promise of continuous bioprocessing while also establishing a novel framework to quantify financial benefits of other platform process technologies. Copyright © 2015 Elsevier B.V. All rights reserved.

  6. Design Considerations for Integration of Terahertz Time-Domain Spectroscopy in Microfluidic Platforms

    Directory of Open Access Journals (Sweden)

    Rasha Al-Hujazy

    2018-03-01

    Full Text Available Microfluidic platforms have received much attention in recent years. In particular, there is interest in combining spectroscopy with microfluidic platforms. This work investigates the integration of microfluidic platforms and terahertz time-domain spectroscopy (THz-TDS systems. A semiclassical computational model is used to simulate the emission of THz radiation from a GaAs photoconductive THz emitter. This model incorporates white noise with increasing noise amplitude (corresponding to decreasing dynamic range values. White noise is selected over other noise due to its contributions in THz-TDS systems. The results from this semiclassical computational model, in combination with defined sample thicknesses, can provide the maximum measurable absorption coefficient for a microfluidic-based THz-TDS system. The maximum measurable frequencies for such systems can be extracted through the relationship between the maximum measurable absorption coefficient and the absorption coefficient for representative biofluids. The sample thickness of the microfluidic platform and the dynamic range of the THz-TDS system play a role in defining the maximum measurable frequency for microfluidic-based THz-TDS systems. The results of this work serve as a design tool for the development of such systems.

  7. Diesel supply planning for offshore platforms by a mathematical model based on the vehicle routing problem with replenishment

    Energy Technology Data Exchange (ETDEWEB)

    Fiorot Astoures, H.; Alvarenga Rosa, R. de; Silva Rosa, A.

    2016-07-01

    Oil exploration in Brazil is mainly held by offshore platforms which require the supply of several products, including diesel to maintain its engines. One strategy to supply diesel to the platforms is to keep a vessel filled with diesel nearby the exploration basin. An empty boat leaves the port and goes directly to this vessel, then it is loaded with diesel. After that, it makes a trip to supply the platforms and when the boat is empty, it returns to the vessel to be reloaded with more diesel going to another trip. Based on this description, this paper proposes a mathematical model based on the Vehicle Routing Problem with Intermediate Replenishment Facilities (VRPIRF) to solve the problem. The purpose of the model is to plan the routes for the boats to meet the diesel requests of the platform. Given the fact that in the literature, papers about the VRPIRF are scarce and papers about the VRPIRF applied to offshore platforms were not found in the published papers, this paper is important to contribute with the evolution of this class of problem, bringing also a solution for a real application that is very important for the oil and gas business. The mathematical model was tested using the CPLEX 12.6. In order to assess the mathematical model, tests were done with data from the major Brazilian oil and gas company and several strategies were tested. (Author)

  8. Educational process in modern climatology within the web-GIS platform "Climate"

    Science.gov (United States)

    Gordova, Yulia; Gorbatenko, Valentina; Gordov, Evgeny; Martynova, Yulia; Okladnikov, Igor; Titov, Alexander; Shulgina, Tamara

    2013-04-01

    These days, common to all scientific fields the problem of training of scientists in the environmental sciences is exacerbated by the need to develop new computational and information technology skills in distributed multi-disciplinary teams. To address this and other pressing problems of Earth system sciences, software infrastructure for information support of integrated research in the geosciences was created based on modern information and computational technologies and a software and hardware platform "Climate» (http://climate.scert.ru/) was developed. In addition to the direct analysis of geophysical data archives, the platform is aimed at teaching the basics of the study of changes in regional climate. The educational component of the platform includes a series of lectures on climate, environmental and meteorological modeling and laboratory work cycles on the basics of analysis of current and potential future regional climate change using Siberia territory as an example. The educational process within the Platform is implemented using the distance learning system Moodle (www.moodle.org). This work is partially supported by the Ministry of education and science of the Russian Federation (contract #8345), SB RAS project VIII.80.2.1, RFBR grant #11-05-01190a, and integrated project SB RAS #131.

  9. Snap: an integrated SNP annotation platform

    DEFF Research Database (Denmark)

    Li, Shengting; Ma, Lijia; Li, Heng

    2007-01-01

    Snap (Single Nucleotide Polymorphism Annotation Platform) is a server designed to comprehensively analyze single genes and relationships between genes basing on SNPs in the human genome. The aim of the platform is to facilitate the study of SNP finding and analysis within the framework of medical...

  10. An Integrated Architecture for Engineering Problem Solving

    National Research Council Canada - National Science Library

    Pisan, Yusuf

    1998-01-01

    .... This thesis describes the Integrated Problem Solving Architecture (IPSA) that combines qualitative, quantitative and diagrammatic reasoning skills to produce annotated solutions to engineering problems...

  11. Integrative Data Analysis of Multi-Platform Cancer Data with a Multimodal Deep Learning Approach.

    Science.gov (United States)

    Liang, Muxuan; Li, Zhizhong; Chen, Ting; Zeng, Jianyang

    2015-01-01

    Identification of cancer subtypes plays an important role in revealing useful insights into disease pathogenesis and advancing personalized therapy. The recent development of high-throughput sequencing technologies has enabled the rapid collection of multi-platform genomic data (e.g., gene expression, miRNA expression, and DNA methylation) for the same set of tumor samples. Although numerous integrative clustering approaches have been developed to analyze cancer data, few of them are particularly designed to exploit both deep intrinsic statistical properties of each input modality and complex cross-modality correlations among multi-platform input data. In this paper, we propose a new machine learning model, called multimodal deep belief network (DBN), to cluster cancer patients from multi-platform observation data. In our integrative clustering framework, relationships among inherent features of each single modality are first encoded into multiple layers of hidden variables, and then a joint latent model is employed to fuse common features derived from multiple input modalities. A practical learning algorithm, called contrastive divergence (CD), is applied to infer the parameters of our multimodal DBN model in an unsupervised manner. Tests on two available cancer datasets show that our integrative data analysis approach can effectively extract a unified representation of latent features to capture both intra- and cross-modality correlations, and identify meaningful disease subtypes from multi-platform cancer data. In addition, our approach can identify key genes and miRNAs that may play distinct roles in the pathogenesis of different cancer subtypes. Among those key miRNAs, we found that the expression level of miR-29a is highly correlated with survival time in ovarian cancer patients. These results indicate that our multimodal DBN based data analysis approach may have practical applications in cancer pathogenesis studies and provide useful guidelines for

  12. Voltage margin control for offshore multi-use platform integration

    DEFF Research Database (Denmark)

    Mier, V.; Casielles, P.G.; Koto, J.

    This paper discusses a multiterminal direct current (MTDC) connection proposed for integration of offshore multi-use platforms into continental grids. Voltage source converters (VSC) were selected for their suitability for multiterminal dc systems and for their flexibility in control. A five...... terminal VSC-MTDC which includes offshore generation, storage, loads and ac connection, was modeled and simulated in DigSILENT Power Factory software. Voltage margin method has been used for reliable operation of the MTDC system without the need of fast communication. Simulation results show......, sell or store energy attending to the price in the electricity market....

  13. Integration of fractal biosensor in a digital microfluidic platform

    KAUST Repository

    Mashraei, Yousof

    2015-11-01

    Fractal capacitive electrodes have been successfully integrated into a digital microfluidic open-platform. These electrodes perform actuation and withstand voltages up to 300V without insulation-layer breakdown. They were used to quantify the concentration levels of C-reactive protein (CRP) to determine the risk of cardiovascular disease. The capacitance increased sevenfold and stabilized in less than 5 minutes. The sensor shows a decreasing trend of capacitance readouts with the increase of concentrations. The same immunoassay was tested with untreated electrodes and showed no significant response, which suggests that immobilization was necessary. This configuration allows the electrodes to be used as biosensors.

  14. Integral equation for Coulomb problem

    International Nuclear Information System (INIS)

    Sasakawa, T.

    1986-01-01

    For short range potentials an inhomogeneous (homogeneous) Lippmann-Schwinger integral equation of the Fredholm type yields the wave function of scattering (bound) state. For the Coulomb potential, this statement is no more valid. It has been felt difficult to express the Coulomb wave function in a form of an integral equation with the Coulomb potential as the perturbation. In the present paper, the author shows that an inhomogeneous integral equation of a Volterra type with the Coulomb potential as the perturbation can be constructed both for the scattering and the bound states. The equation yielding the binding energy is given in an integral form. The present treatment is easily extended to the coupled Coulomb problems

  15. VR-Cluster: Dynamic Migration for Resource Fragmentation Problem in Virtual Router Platform

    Directory of Open Access Journals (Sweden)

    Xianming Gao

    2016-01-01

    Full Text Available Network virtualization technology is regarded as one of gradual schemes to network architecture evolution. With the development of network functions virtualization, operators make lots of effort to achieve router virtualization by using general servers. In order to ensure high performance, virtual router platform usually adopts a cluster of general servers, which can be also regarded as a special cloud computing environment. However, due to frequent creation and deletion of router instances, it may generate lots of resource fragmentation to prevent platform from establishing new router instances. In order to solve “resource fragmentation problem,” we firstly propose VR-Cluster, which introduces two extra function planes including switching plane and resource management plane. Switching plane is mainly used to support seamless migration of router instances without packet loss; resource management plane can dynamically move router instances from one server to another server by using VR-mapping algorithms. Besides, three VR-mapping algorithms including first-fit mapping algorithm, best-fit mapping algorithm, and worst-fit mapping algorithm are proposed based on VR-Cluster. At last, we establish VR-Cluster protosystem by using general X86 servers, evaluate its migration time, and further analyze advantages and disadvantages of our proposed VR-mapping algorithms to solve resource fragmentation problem.

  16. Platform Performance and Challenges - using Platforms in Lego Company

    DEFF Research Database (Denmark)

    Munk, Lone; Mortensen, Niels Henrik

    2009-01-01

    needs focus on the incentive of using the platform. This problem lacks attention in literature, as well as industry, where assessment criteria do not cover this aspect. Therefore, we recommend including user incentive in platform assessment criteria to these challenges. Concrete solution elements...... ensuring user incentive in platforms is an object for future research...

  17. Information Integration Platform for Patient-Centric Healthcare Services: Design, Prototype and Dependability Aspects

    Directory of Open Access Journals (Sweden)

    Yohanes Baptista Dafferianto Trinugroho

    2014-03-01

    Full Text Available Technology innovations have pushed today’s healthcare sector to an unprecedented new level. Various portable and wearable medical and fitness devices are being sold in the consumer market to provide the self-empowerment of a healthier lifestyle to society. Many vendors provide additional cloud-based services for devices they manufacture, enabling the users to visualize, store and share the gathered information through the Internet. However, most of these services are integrated with the devices in a closed “silo” manner, where the devices can only be used with the provided services. To tackle this issue, an information integration platform (IIP has been developed to support communications between devices and Internet-based services in an event-driven fashion by adopting service-oriented architecture (SOA principles and a publish/subscribe messaging pattern. It follows the “Internet of Things” (IoT idea of connecting everyday objects to various networks and to enable the dissemination of the gathered information to the global information space through the Internet. A patient-centric healthcare service environment is chosen as the target scenario for the deployment of the platform, as this is a domain where IoT can have a direct positive impact on quality of life enhancement. This paper describes the developed platform, with emphasis on dependability aspects, including availability, scalability and security.

  18. The Riesz-Radon-Frechet problem of characterization of integrals

    Energy Technology Data Exchange (ETDEWEB)

    Zakharov, Valerii K; Rodionov, Timofey V [M. V. Lomonosov Moscow State University, Moscow (Russian Federation); Mikhalev, Aleksandr V [Centre for New Information Technologies, Moscow State University (Russian Federation)

    2010-11-16

    This paper is a survey of results on characterizing integrals as linear functionals. It starts from the familiar result of F. Riesz (1909) on integral representation of bounded linear functionals by Riemann-Stieltjes integrals on a closed interval, and is directly connected with Radon's famous theorem (1913) on integral representation of bounded linear functionals by Lebesgue integrals on a compact subset of R{sup n}. After the works of Radon, Frechet, and Hausdorff, the problem of characterizing integrals as linear functionals took the particular form of the problem of extending Radon's theorem from R{sup n} to more general topological spaces with Radon measures. This problem turned out to be difficult, and its solution has a long and rich history. Therefore, it is natural to call it the Riesz-Radon-Frechet problem of characterization of integrals. Important stages of its solution are associated with such eminent mathematicians as Banach (1937-1938), Saks (1937-1938), Kakutani (1941), Halmos (1950), Hewitt (1952), Edwards (1953), Prokhorov (1956), Bourbaki (1969), and others. Essential ideas and technical tools were developed by A.D. Alexandrov (1940-1943), Stone (1948-1949), Fremlin (1974), and others. Most of this paper is devoted to the contemporary stage of the solution of the problem, connected with papers of Koenig (1995-2008), Zakharov and Mikhalev (1997-2009), and others. The general solution of the problem is presented in the form of a parametric theorem on characterization of integrals which directly implies the characterization theorems of the indicated authors. Bibliography: 60 titles.

  19. The Riesz-Radon-Frechet problem of characterization of integrals

    International Nuclear Information System (INIS)

    Zakharov, Valerii K; Rodionov, Timofey V; Mikhalev, Aleksandr V

    2010-01-01

    This paper is a survey of results on characterizing integrals as linear functionals. It starts from the familiar result of F. Riesz (1909) on integral representation of bounded linear functionals by Riemann-Stieltjes integrals on a closed interval, and is directly connected with Radon's famous theorem (1913) on integral representation of bounded linear functionals by Lebesgue integrals on a compact subset of R n . After the works of Radon, Frechet, and Hausdorff, the problem of characterizing integrals as linear functionals took the particular form of the problem of extending Radon's theorem from R n to more general topological spaces with Radon measures. This problem turned out to be difficult, and its solution has a long and rich history. Therefore, it is natural to call it the Riesz-Radon-Frechet problem of characterization of integrals. Important stages of its solution are associated with such eminent mathematicians as Banach (1937-1938), Saks (1937-1938), Kakutani (1941), Halmos (1950), Hewitt (1952), Edwards (1953), Prokhorov (1956), Bourbaki (1969), and others. Essential ideas and technical tools were developed by A.D. Alexandrov (1940-1943), Stone (1948-1949), Fremlin (1974), and others. Most of this paper is devoted to the contemporary stage of the solution of the problem, connected with papers of Koenig (1995-2008), Zakharov and Mikhalev (1997-2009), and others. The general solution of the problem is presented in the form of a parametric theorem on characterization of integrals which directly implies the characterization theorems of the indicated authors. Bibliography: 60 titles.

  20. Multilayered photonic integration on SOI platform using waveguide-based bridge structure

    Science.gov (United States)

    Majumder, Saikat; Chakraborty, Rajib

    2018-06-01

    A waveguide based structure on silicon on insulator platform is proposed for vertical integration in photonic integrated circuits. The structure consists of two multimode interference couplers connected by a single mode (SM) section which can act as a bridge over any other underlying device. Two more SM sections acts as input and output of the first and second multimode couplers respectively. Potential application of this structure is in multilayered photonic links. It is shown that the efficiency of the structure can be improved by making some design modifications. The entire simulation is done using effective-index based matrix method. The feature size chosen are comparable to waveguides fabricated previously so as to fabricate the proposed structure easily.

  1. Oil and gas platforms with steam bottoming cycles: System integration and thermoenvironomic evaluation

    DEFF Research Database (Denmark)

    Nguyen, Tuong-Van; Tock, Laurence; Breuhaus, Peter

    2014-01-01

    The integration of steam bottoming cycles on oil and gas platforms is currently regarded as the most promising option for improving the performance of these energy-intensive systems. In this paper, a North Sea platform is taken as case study, and a systematic analysis of its energy requirements...... cooling utility, and (iv) the weight limitations on the platform are quantitatively assessed. The results illustrate the benefits of converting the gas turbine process into a combined cycle, since the fuel gas consumption and the total CO2-emissions can be reduced by more than 15 %. Using the cooling...... water from the processing plant reveals to be more profitable than using seawater, as the additional pumping power outweighs the benefit of using a cooling medium at a temperature of about 8 °C lower. This study highlights thereby the importance of analysing energy savings and recovery options...

  2. Performance Measurement of Complex Event Platforms

    Directory of Open Access Journals (Sweden)

    Eva Zámečníková

    2016-12-01

    Full Text Available The aim of this paper is to find and compare existing solutions of complex event processing platforms (CEP. CEP platforms generally serve for processing and/or predicting of high frequency data. We intend to use CEP platform for processing of complex time series and integrate a solution for newly proposed method of decision making. The decision making process will be described by formal grammar. As there are lots of CEP solutions we will take the following characteristics under consideration - the processing in real time, possibility of processing of high volume data from multiple sources, platform independence, platform allowing integration with user solution and open license. At first we will talk about existing CEP tools and their specific way of use in praxis. Then we will mention the design of method for formalization of business rules used for decision making. Afterwards, we focus on two platforms which seem to be the best fit for integration of our solution and we will list the main pros and cons of each approach. Next part is devoted to benchmark platforms for CEP. Final part is devoted to experimental measurements of platform with integrated method for decision support.

  3. Integrated vehicle-based safety systems (IVBSS) : light vehicle platform field operational test data analysis plan.

    Science.gov (United States)

    2009-12-22

    This document presents the University of Michigan Transportation Research Institutes plan to : perform analysis of data collected from the light vehicle platform field operational test of the : Integrated Vehicle-Based Safety Systems (IVBSS) progr...

  4. Integrated vehicle-based safety systems (IVBSS) : heavy truck platform field operational test data analysis plan.

    Science.gov (United States)

    2009-11-23

    This document presents the University of Michigan Transportation Research Institutes plan to perform : analysis of data collected from the heavy truck platform field operational test of the Integrated Vehicle- : Based Safety Systems (IVBSS) progra...

  5. Study on Photon Transport Problem Based on the Platform of Molecular Optical Simulation Environment

    Directory of Open Access Journals (Sweden)

    Kuan Peng

    2010-01-01

    Full Text Available As an important molecular imaging modality, optical imaging has attracted increasing attention in the recent years. Since the physical experiment is usually complicated and expensive, research methods based on simulation platforms have obtained extensive attention. We developed a simulation platform named Molecular Optical Simulation Environment (MOSE to simulate photon transport in both biological tissues and free space for optical imaging based on noncontact measurement. In this platform, Monte Carlo (MC method and the hybrid radiosity-radiance theorem are used to simulate photon transport in biological tissues and free space, respectively, so both contact and noncontact measurement modes of optical imaging can be simulated properly. In addition, a parallelization strategy for MC method is employed to improve the computational efficiency. In this paper, we study the photon transport problems in both biological tissues and free space using MOSE. The results are compared with Tracepro, simplified spherical harmonics method (SPn, and physical measurement to verify the performance of our study method on both accuracy and efficiency.

  6. Study on photon transport problem based on the platform of molecular optical simulation environment.

    Science.gov (United States)

    Peng, Kuan; Gao, Xinbo; Liang, Jimin; Qu, Xiaochao; Ren, Nunu; Chen, Xueli; Ma, Bin; Tian, Jie

    2010-01-01

    As an important molecular imaging modality, optical imaging has attracted increasing attention in the recent years. Since the physical experiment is usually complicated and expensive, research methods based on simulation platforms have obtained extensive attention. We developed a simulation platform named Molecular Optical Simulation Environment (MOSE) to simulate photon transport in both biological tissues and free space for optical imaging based on noncontact measurement. In this platform, Monte Carlo (MC) method and the hybrid radiosity-radiance theorem are used to simulate photon transport in biological tissues and free space, respectively, so both contact and noncontact measurement modes of optical imaging can be simulated properly. In addition, a parallelization strategy for MC method is employed to improve the computational efficiency. In this paper, we study the photon transport problems in both biological tissues and free space using MOSE. The results are compared with Tracepro, simplified spherical harmonics method (SP(n)), and physical measurement to verify the performance of our study method on both accuracy and efficiency.

  7. VOLTTRON Lite: Integration Platform for the Transactional Network

    Energy Technology Data Exchange (ETDEWEB)

    Haack, Jereme N.; Katipamula, Srinivas; Akyol, Bora A.; Lutes, Robert G.

    2013-10-31

    In FY13, Pacific Northwest National Laboratory (PNNL) with funding from the Department of Energy’s (DOE’s) Building Technologies Office (BTO) designed, prototyped and tested a transactional network platform. The platform is intended to support energy, operational and financial transactions between any networked entities (equipment, organizations, buildings, grid, etc.). Initially, in FY13, the concept demonstrated transactions between packaged rooftop units (RTUs) and the electric grid using applications or “agents” that reside on the platform, on the equipment, on local building controller or in the Cloud. This document describes the core of the transactional network platform, the Volttron Lite™ software and associated services hosted on the platform. Future enhancements are also discussed. The appendix of the document provides examples of how to use the various services hosted on the platform.

  8. Power System and Energy Storage Models for Laser Integration on Naval Platforms

    Science.gov (United States)

    2015-09-30

    Power System and Energy Storage Models for Laser Integration on Naval Platforms A.L. Gattozzi, J.D. Herbst, R.E. Hebner Center for... Electromechanics , University of Texas Austin, Texas a.gattozzi@cem.utexas.edu J.A. Blau, K.R. Cohn, W.B. Colson, J.E. Sylvester, M.A. Woehrman Physics...emerging technologies present significant challenges to the electric power distribution and thermal management systems, particularly for

  9. COMMUNITARIAN DIMENSION OF SOCIAL INTEGRITY PROBLEM

    Directory of Open Access Journals (Sweden)

    Yuliia Yu. Brodetskaya

    2015-05-01

    Full Text Available The purpose. The article focuses on the study analysis of the theoretical and methodological preconditions of the social integrity phenomenon research. The nature of the modern social and cultural changes discloses a crisis of the social theory that is aimed to study the conditions and mechanisms of the social modernity development. Modern social theory appears against the background of the classical research methodology issues – Aristotle's political philosophy, which interprets sociality as a political aspect. However, modern social theory attempts to overcome the crisis of the rational project by forming a communitarians’ ideology. In order to solve the problem of the social integrity and order, being an alternative to the rationalistic individualism of society liberal theory, the theory of communitarism reveals the potential of communities. The communities are those models of social that can overcome individualism of a modern man and society, destroy the cult of statism. Thus, as a research methodology of the social integrity issues the communitarian approach is used, as it actualizes the potential of the communities. This methodological step reveals the social at a qualitatively different socio-cultural level of analysis, as a certain model of the human relations that base not only on the economic and legal relations (relations, property, division of labor and power, etc., but also, and above all, on the spiritual ones (culture of community, communication, informal regulation of relations, etc.. The scientific novelty of this work is to try to expand the heuristic possibilities of the com munitarian theory in terms of the analysis of the social integrity problems in order to create a comprehensive research methodology of the problem. Conclusions. Thus, the study of the community potential, its mechanisms and the logic of its generation and presentation in the modern society allows to reveal the conditions of the

  10. Integration of nanostructured materials with MEMS microhotplate platforms to enhance chemical sensor performance

    International Nuclear Information System (INIS)

    Benkstein, Kurt D.; Martinez, Carlos J.; Li, Guofeng; Meier, Douglas C.; Montgomery, Christopher B.; Semancik, Steve

    2006-01-01

    The development of miniaturized chemical sensors is an increasingly active area of research. Such devices, particularly when they feature low mass and low power budgets, can impact a broad range of applications including industrial process monitoring, building security and extraterrestrial exploration. Nanostructured materials, because of their high surface area, can provide critical enhancements in the performance of chemical microsensors. We have worked to integrate nanomaterial films with MEMS (microelectromechanical systems) microhotplate platforms developed at the National Institute of Standards and Technology in order to gain the benefits of both the materials and the platforms in high-performance chemical sensor arrays. Here, we describe our success in overcoming the challenges of integration and the benefits that we have achieved with regard to the critical sensor performance characteristics of sensor response, speed, stability and selectivity. Nanostructured metal oxide sensing films were locally deposited onto microhotplates via chemical vapor deposition and microcapillary pipetting, and conductive polymer nanoparticle films were deposited via electrophoretic patterning. All films were characterized by scanning electron microscopy and evaluated as conductometric gas sensors

  11. Monolithic photonic integration technology platform and devices at wavelengths beyond 2 μm for gas spectroscopy applications

    NARCIS (Netherlands)

    Latkowski, S.; van Veldhoven, P.J.; Hänsel, A.; D'Agostino, D.; Rabbani-Haghighi, H.; Docter, B.; Bhattacharya, N.; Thijs, P.J.A.; Ambrosius, H.P.M.M.; Smit, M.K.; Williams, K.A.; Bente, E.A.J.M.

    2017-01-01

    In this paper a generic monolithic photonic integration technology platform and tunable laser devices for gas sensing applications at 2 μm will be presented. The basic set of long wavelength optical functions which is fundamental for a generic photonic integration approach is realized using planar,

  12. Paper-based electrochemical sensing platform with integral battery and electrochromic read-out.

    Science.gov (United States)

    Liu, Hong; Crooks, Richard M

    2012-03-06

    We report a battery-powered, microelectrochemical sensing platform that reports its output using an electrochromic display. The platform is fabricated based on paper fluidics and uses a Prussian blue spot electrodeposited on an indium-doped tin oxide thin film as the electrochromic indicator. The integrated metal/air battery powers both the electrochemical sensor and the electrochromic read-out, which are in electrical contact via a paper reservoir. The sample activates the battery and the presence of analyte in the sample initiates the color change of the Prussian blue spot. The entire system is assembled on the lab bench, without the need for cleanroom facilities. The applicability of the device to point-of-care sensing is demonstrated by qualitative detection of 0.1 mM glucose and H(2)O(2) in artificial urine samples.

  13. On the Formal Integrability Problem for Planar Differential Systems

    Directory of Open Access Journals (Sweden)

    Antonio Algaba

    2013-01-01

    Full Text Available We study the analytic integrability problem through the formal integrability problem and we show its connection, in some cases, with the existence of invariant analytic (sometimes algebraic curves. From the results obtained, we consider some families of analytic differential systems in ℂ2, and imposing the formal integrability we find resonant centers obviating the computation of some necessary conditions.

  14. SERVIR-Africa: Developing an Integrated Platform for Floods Disaster Management in Africa

    Science.gov (United States)

    Macharia, Daniel; Korme, Tesfaye; Policelli, Fritz; Irwin, Dan; Adler, Bob; Hong, Yang

    2010-01-01

    SERVIR-Africa is an ambitious regional visualization and monitoring system that integrates remotely sensed data with predictive models and field-based data to monitor ecological processes and respond to natural disasters. It aims addressing societal benefits including floods and turning data into actionable information for decision-makers. Floods are exogenous disasters that affect many parts of Africa, probably second only to drought in terms of social-economic losses. This paper looks at SERVIR-Africa's approach to floods disaster management through establishment of an integrated platform, floods prediction models, post-event flood mapping and monitoring as well as flood maps dissemination in support of flood disaster management.

  15. Applying Groebner bases to solve reduction problems for Feynman integrals

    International Nuclear Information System (INIS)

    Smirnov, Alexander V.; Smirnov, Vladimir A.

    2006-01-01

    We describe how Groebner bases can be used to solve the reduction problem for Feynman integrals, i.e. to construct an algorithm that provides the possibility to express a Feynman integral of a given family as a linear combination of some master integrals. Our approach is based on a generalized Buchberger algorithm for constructing Groebner-type bases associated with polynomials of shift operators. We illustrate it through various examples of reduction problems for families of one- and two-loop Feynman integrals. We also solve the reduction problem for a family of integrals contributing to the three-loop static quark potential

  16. Applying Groebner bases to solve reduction problems for Feynman integrals

    Energy Technology Data Exchange (ETDEWEB)

    Smirnov, Alexander V. [Mechanical and Mathematical Department and Scientific Research Computer Center of Moscow State University, Moscow 119992 (Russian Federation); Smirnov, Vladimir A. [Nuclear Physics Institute of Moscow State University, Moscow 119992 (Russian Federation)

    2006-01-15

    We describe how Groebner bases can be used to solve the reduction problem for Feynman integrals, i.e. to construct an algorithm that provides the possibility to express a Feynman integral of a given family as a linear combination of some master integrals. Our approach is based on a generalized Buchberger algorithm for constructing Groebner-type bases associated with polynomials of shift operators. We illustrate it through various examples of reduction problems for families of one- and two-loop Feynman integrals. We also solve the reduction problem for a family of integrals contributing to the three-loop static quark potential.

  17. Using a blog as an integrated eLearning tool and platform.

    Science.gov (United States)

    Goh, Poh Sun

    2016-06-01

    Technology enhanced learning or eLearning allows educators to expand access to educational content, promotes engagement with students and makes it easier for students to access educational material at a time, place and pace which suits them. The challenge for educators beginning their eLearning journey is to decide where to start, which includes the choice of an eLearning tool and platform. This article will share one educator's decision making process, and experience using blogs as a flexible and versatile integrated eLearning tool and platform. Apart from being a cost effective/free tool and platform, blogs offer the possibility of creating a hyperlinked indexed content repository, for both created and curated educational material; as well as a distribution and engagement tool and platform. Incorporating pedagogically sound activities and educational practices into a blog promote a structured templated teaching process, which can be reproduced. Moving from undergraduate to postgraduate training, educational blogs supported by a comprehensive online case-based repository offer the possibility of training beyond competency towards proficiency and expert level performance through a process of deliberate practice. By documenting educational content and the student engagement and learning process, as well as feedback and personal reflection of educational sessions, blogs can also form the basis for a teaching portfolio, and provide evidence and data of scholarly teaching and educational scholarship. Looking into the future, having a collection of readily accessible indexed hyperlinked teaching material offers the potential to do on the spot teaching with illustrative material called up onto smart surfaces, and displayed on holographic interfaces.

  18. A Ubiquitous Sensor Network Platform for Integrating Smart Devices into the Semantic Sensor Web

    Science.gov (United States)

    de Vera, David Díaz Pardo; Izquierdo, Álvaro Sigüenza; Vercher, Jesús Bernat; Gómez, Luis Alfonso Hernández

    2014-01-01

    Ongoing Sensor Web developments make a growing amount of heterogeneous sensor data available to smart devices. This is generating an increasing demand for homogeneous mechanisms to access, publish and share real-world information. This paper discusses, first, an architectural solution based on Next Generation Networks: a pilot Telco Ubiquitous Sensor Network (USN) Platform that embeds several OGC® Sensor Web services. This platform has already been deployed in large scale projects. Second, the USN-Platform is extended to explore a first approach to Semantic Sensor Web principles and technologies, so that smart devices can access Sensor Web data, allowing them also to share richer (semantically interpreted) information. An experimental scenario is presented: a smart car that consumes and produces real-world information which is integrated into the Semantic Sensor Web through a Telco USN-Platform. Performance tests revealed that observation publishing times with our experimental system were well within limits compatible with the adequate operation of smart safety assistance systems in vehicles. On the other hand, response times for complex queries on large repositories may be inappropriate for rapid reaction needs. PMID:24945678

  19. Integration Platform As Central Service Of Data Replication In Distributed Medical System

    Directory of Open Access Journals (Sweden)

    Wiesław Wajs

    2007-01-01

    Full Text Available The paper presents the application of Java Integration Platform (JIP to data replicationin the distributed medical system. After an introductory part on the medical system’s architecture,the focus shifts to a comparison of different approaches that exist with regard totransferring data between the system’s components. A description is given of the historicaldata processing and of the whole area of the JIP application to the medical system.

  20. Integrated nanophotonic frequency shifter on the silicon-organic hybrid (SOH) platform for laser vibrometry

    International Nuclear Information System (INIS)

    Lauermann, M.; Weimann, C.; Palmer, R.; Schindler, P. C.; Koeber, S.; Freude, W.; Koos, C.; Rembe, C.

    2014-01-01

    We demonstrate a waveguide-based frequency shifter on the silicon photonic platform, enabling frequency shifts up to 10 GHz. The device is realized by silicon-organic hybrid (SOH) integration. Temporal shaping of the drive signal allows the suppression of spurious side-modes by more than 23 dB

  1. Integrated nanophotonic frequency shifter on the silicon-organic hybrid (SOH) platform for laser vibrometry

    Energy Technology Data Exchange (ETDEWEB)

    Lauermann, M.; Weimann, C.; Palmer, R.; Schindler, P. C. [Institute of Photonics and Quantum Electronics, Karlsruhe Institute of Technology, 76131 Karlsruhe (Germany); Koeber, S.; Freude, W., E-mail: christian.koos@kit.edu; Koos, C., E-mail: christian.koos@kit.edu [Institute of Photonics and Quantum Electronics, Karlsruhe Institute of Technology, 76131 Karlsruhe, Germany and Institute of Microstructure Technology, Karlsruhe Institute of Technology, 76344 Eggenstein-Leopoldshafen (Germany); Rembe, C. [Polytec GmbH, 76337 Waldbronn (Germany)

    2014-05-27

    We demonstrate a waveguide-based frequency shifter on the silicon photonic platform, enabling frequency shifts up to 10 GHz. The device is realized by silicon-organic hybrid (SOH) integration. Temporal shaping of the drive signal allows the suppression of spurious side-modes by more than 23 dB.

  2. InP-based photonic integrated circuit platform on SiC wafer.

    Science.gov (United States)

    Takenaka, Mitsuru; Takagi, Shinichi

    2017-11-27

    We have numerically investigated the properties of an InP-on-SiC wafer as a photonic integrated circuit (PIC) platform. By bonding a thin InP-based semiconductor on a SiC wafer, SiC can be used as waveguide cladding, a heat sink, and a support substrate simultaneously. Since the refractive index of SiC is sufficiently low, PICs can be fabricated using InP-based strip and rib waveguides with a minimum bend radius of approximately 7 μm. High-thermal-conductivity SiC underneath an InP-based waveguide core markedly improves heat dissipation, resulting in superior thermal properties of active devices such as laser diodes. The InP-on-SiC wafer has significantly smaller thermal stress than InP-on-SiO 2 /Si wafer, which prevents the thermal degradation of InP-based devices during high-temperature processes. Thus, InP on SiC provides an ideal platform for high-performance PICs.

  3. Titanium dioxide nanowire sensor array integration on CMOS platform using deterministic assembly.

    Science.gov (United States)

    Gall, Oren Z; Zhong, Xiahua; Schulman, Daniel S; Kang, Myungkoo; Razavieh, Ali; Mayer, Theresa S

    2017-06-30

    Nanosensor arrays have recently received significant attention due to their utility in a wide range of applications, including gas sensing, fuel cells, internet of things, and portable health monitoring systems. Less attention has been given to the production of sensor platforms in the μW range for ultra-low power applications. Here, we discuss how to scale the nanosensor energy demand by developing a process for integration of nanowire sensing arrays on a monolithic CMOS chip. This work demonstrates an off-chip nanowire fabrication method; subsequently nanowires link to a fused SiO 2 substrate using electric-field assisted directed assembly. The nanowire resistances shown in this work have the highest resistance uniformity reported to date of 18%, which enables a practical roadmap towards the coupling of nanosensors to CMOS circuits and signal processing systems. The article also presents the utility of optimizing annealing conditions of the off-chip metal-oxides prior to CMOS integration to avoid limitations of thermal budget and process incompatibility. In the context of the platform demonstrated here, directed assembly is a powerful tool that can realize highly uniform, cross-reactive arrays of different types of metal-oxide nanosensors suited for gas discrimination and signal processing systems.

  4. Integration of the HTC Vive into the medical platform MeVisLab

    Science.gov (United States)

    Egger, Jan; Gall, Markus; Wallner, Jürgen; de Almeida Germano Boechat, Pedro; Hann, Alexander; Li, Xing; Chen, Xiaojun; Schmalstieg, Dieter

    2017-03-01

    Virtual Reality (VR) is an immersive technology that replicates an environment via computer-simulated reality. VR gets a lot of attention in computer games but has also great potential in other areas, like the medical domain. Examples are planning, simulations and training of medical interventions, like for facial surgeries where an aesthetic outcome is important. However, importing medical data into VR devices is not trivial, especially when a direct connection and visualization from your own application is needed. Furthermore, most researcher don't build their medical applications from scratch, rather they use platforms, like MeVisLab, Slicer or MITK. The platforms have in common that they integrate and build upon on libraries like ITK and VTK, further providing a more convenient graphical interface to them for the user. In this contribution, we demonstrate the usage of a VR device for medical data under MeVisLab. Therefore, we integrated the OpenVR library into MeVisLab as an own module. This enables the direct and uncomplicated usage of head mounted displays, like the HTC Vive under MeVisLab. Summarized, medical data from other MeVisLab modules can directly be connected per drag-and-drop to our VR module and will be rendered inside the HTC Vive for an immersive inspection.

  5. Study on Photon Transport Problem Based on the Platform of Molecular Optical Simulation Environment

    Science.gov (United States)

    Peng, Kuan; Gao, Xinbo; Liang, Jimin; Qu, Xiaochao; Ren, Nunu; Chen, Xueli; Ma, Bin; Tian, Jie

    2010-01-01

    As an important molecular imaging modality, optical imaging has attracted increasing attention in the recent years. Since the physical experiment is usually complicated and expensive, research methods based on simulation platforms have obtained extensive attention. We developed a simulation platform named Molecular Optical Simulation Environment (MOSE) to simulate photon transport in both biological tissues and free space for optical imaging based on noncontact measurement. In this platform, Monte Carlo (MC) method and the hybrid radiosity-radiance theorem are used to simulate photon transport in biological tissues and free space, respectively, so both contact and noncontact measurement modes of optical imaging can be simulated properly. In addition, a parallelization strategy for MC method is employed to improve the computational efficiency. In this paper, we study the photon transport problems in both biological tissues and free space using MOSE. The results are compared with Tracepro, simplified spherical harmonics method (S P n), and physical measurement to verify the performance of our study method on both accuracy and efficiency. PMID:20445737

  6. G-DOC Plus - an integrative bioinformatics platform for precision medicine.

    Science.gov (United States)

    Bhuvaneshwar, Krithika; Belouali, Anas; Singh, Varun; Johnson, Robert M; Song, Lei; Alaoui, Adil; Harris, Michael A; Clarke, Robert; Weiner, Louis M; Gusev, Yuriy; Madhavan, Subha

    2016-04-30

    G-DOC Plus is a data integration and bioinformatics platform that uses cloud computing and other advanced computational tools to handle a variety of biomedical BIG DATA including gene expression arrays, NGS and medical images so that they can be analyzed in the full context of other omics and clinical information. G-DOC Plus currently holds data from over 10,000 patients selected from private and public resources including Gene Expression Omnibus (GEO), The Cancer Genome Atlas (TCGA) and the recently added datasets from REpository for Molecular BRAin Neoplasia DaTa (REMBRANDT), caArray studies of lung and colon cancer, ImmPort and the 1000 genomes data sets. The system allows researchers to explore clinical-omic data one sample at a time, as a cohort of samples; or at the level of population, providing the user with a comprehensive view of the data. G-DOC Plus tools have been leveraged in cancer and non-cancer studies for hypothesis generation and validation; biomarker discovery and multi-omics analysis, to explore somatic mutations and cancer MRI images; as well as for training and graduate education in bioinformatics, data and computational sciences. Several of these use cases are described in this paper to demonstrate its multifaceted usability. G-DOC Plus can be used to support a variety of user groups in multiple domains to enable hypothesis generation for precision medicine research. The long-term vision of G-DOC Plus is to extend this translational bioinformatics platform to stay current with emerging omics technologies and analysis methods to continue supporting novel hypothesis generation, analysis and validation for integrative biomedical research. By integrating several aspects of the disease and exposing various data elements, such as outpatient lab workup, pathology, radiology, current treatments, molecular signatures and expected outcomes over a web interface, G-DOC Plus will continue to strengthen precision medicine research. G-DOC Plus is available

  7. Jenkins-CI, an Open-Source Continuous Integration System, as a Scientific Data and Image-Processing Platform

    Science.gov (United States)

    Moutsatsos, Ioannis K.; Hossain, Imtiaz; Agarinis, Claudia; Harbinski, Fred; Abraham, Yann; Dobler, Luc; Zhang, Xian; Wilson, Christopher J.; Jenkins, Jeremy L.; Holway, Nicholas; Tallarico, John; Parker, Christian N.

    2016-01-01

    High-throughput screening generates large volumes of heterogeneous data that require a diverse set of computational tools for management, processing, and analysis. Building integrated, scalable, and robust computational workflows for such applications is challenging but highly valuable. Scientific data integration and pipelining facilitate standardized data processing, collaboration, and reuse of best practices. We describe how Jenkins-CI, an “off-the-shelf,” open-source, continuous integration system, is used to build pipelines for processing images and associated data from high-content screening (HCS). Jenkins-CI provides numerous plugins for standard compute tasks, and its design allows the quick integration of external scientific applications. Using Jenkins-CI, we integrated CellProfiler, an open-source image-processing platform, with various HCS utilities and a high-performance Linux cluster. The platform is web-accessible, facilitates access and sharing of high-performance compute resources, and automates previously cumbersome data and image-processing tasks. Imaging pipelines developed using the desktop CellProfiler client can be managed and shared through a centralized Jenkins-CI repository. Pipelines and managed data are annotated to facilitate collaboration and reuse. Limitations with Jenkins-CI (primarily around the user interface) were addressed through the selection of helper plugins from the Jenkins-CI community. PMID:27899692

  8. Jenkins-CI, an Open-Source Continuous Integration System, as a Scientific Data and Image-Processing Platform.

    Science.gov (United States)

    Moutsatsos, Ioannis K; Hossain, Imtiaz; Agarinis, Claudia; Harbinski, Fred; Abraham, Yann; Dobler, Luc; Zhang, Xian; Wilson, Christopher J; Jenkins, Jeremy L; Holway, Nicholas; Tallarico, John; Parker, Christian N

    2017-03-01

    High-throughput screening generates large volumes of heterogeneous data that require a diverse set of computational tools for management, processing, and analysis. Building integrated, scalable, and robust computational workflows for such applications is challenging but highly valuable. Scientific data integration and pipelining facilitate standardized data processing, collaboration, and reuse of best practices. We describe how Jenkins-CI, an "off-the-shelf," open-source, continuous integration system, is used to build pipelines for processing images and associated data from high-content screening (HCS). Jenkins-CI provides numerous plugins for standard compute tasks, and its design allows the quick integration of external scientific applications. Using Jenkins-CI, we integrated CellProfiler, an open-source image-processing platform, with various HCS utilities and a high-performance Linux cluster. The platform is web-accessible, facilitates access and sharing of high-performance compute resources, and automates previously cumbersome data and image-processing tasks. Imaging pipelines developed using the desktop CellProfiler client can be managed and shared through a centralized Jenkins-CI repository. Pipelines and managed data are annotated to facilitate collaboration and reuse. Limitations with Jenkins-CI (primarily around the user interface) were addressed through the selection of helper plugins from the Jenkins-CI community.

  9. Integration of the TNXYZ computer program inside the platform Salome; Integracion del programa de computo TNXYZ dentro de la plataforma Salome

    Energy Technology Data Exchange (ETDEWEB)

    Chaparro V, F. J.

    2014-07-01

    The present work shows the procedure carried out to integrate the code TNXYZ as a calculation tool at the graphical simulation platform Salome. The TNXYZ code propose a numerical solution of the neutron transport equation, in several groups of energy, steady-state and three-dimensional geometry. In order to discretized the variables of the transport equation, the code uses the method of discrete ordinates for the angular variable, and a nodal method for the spatial dependence. The Salome platform is a graphical environment designed for building, editing and simulating mechanical models mainly focused on the industry and unlike other software, in order to form a complete scheme of pre and post processing of information, to integrate and control an external source code. Before the integration the in the Salome platform TNXYZ code was upgraded. TNXYZ was programmed in the 90s using Fortran 77 compiler; for this reason the code was adapted to the characteristics of the current Fortran compilers; in addition, with the intention of extracting partial results over the process sequence, the original structure of the program underwent a modularization process, i.e. the main program was divided into sections where the code performs major operations. This procedure is controlled by the information module (YACS) on Salome platform, and it could be useful for a subsequent coupling with thermal-hydraulics codes. Finally, with the help of the Monte Carlo code Serpent several study cases were defined in order to check the process of integration; the verification process consisted in performing a comparison of the results obtained with the code executed as stand-alone and after modernized, integrated and controlled by the Salome platform. (Author)

  10. Design of a Maglev Vibration Test Platform for the Research of Maglev Vehicle-girder Coupled Vibration Problem

    Directory of Open Access Journals (Sweden)

    Zhou Danfeng

    2017-01-01

    Full Text Available The maglev vehicle-girder coupled vibration problem has been encountered in many maglev test or commercial lines, which significantly degrade the performance of the maglev train. In previous research on the principle of the coupled vibration problem, it has been discovered that the fundamental model of the maglev girder can be simplified as a series of mass-spring resonators of different but related resonance frequencies, and that the stability of the vehicle-girder coupled system can be investigated by separately examining the stability of each mass-spring resonator – electromagnet coupled system. Based on this conclusion, a maglev test platform, which includes a single electromagnetic suspension control system, is built for experimental study of the coupled vibration problem. The guideway of the test platform is supported by a number of springs so as to change its flexibility. The mass of the guideway can also be changed by adjusting extra weights attached to it. By changing the flexibility and mass of the guideway, the rules of the maglev vehicle-girder coupled vibration problem are to be examined through experiments, and related theory on the vehicle-girder self-excited vibration proposed in previous research is also testified.

  11. Stochastic programming problems with generalized integrated chance constraints

    Czech Academy of Sciences Publication Activity Database

    Branda, Martin

    2012-01-01

    Roč. 61, č. 8 (2012), s. 949-968 ISSN 0233-1934 R&D Projects: GA ČR GAP402/10/1610 Grant - others:SVV(CZ) 261315/2010 Institutional support: RVO:67985556 Keywords : chance constraints * integrated chance constraints * penalty functions * sample approximations * blending problem Subject RIV: BB - Applied Statistics, Operational Research Impact factor: 0.707, year: 2012 http://library.utia.cas.cz/separaty/2012/E/branda-stochastic programming problems with generalized integrated.pdf

  12. Supporting Building Portfolio Investment and Policy Decision Making through an Integrated Building Utility Data Platform

    Energy Technology Data Exchange (ETDEWEB)

    Aziz, Azizan [Carnegie Mellon Univ., Pittsburgh, PA (United States); Lasternas, Bertrand [Carnegie Mellon Univ., Pittsburgh, PA (United States); Alschuler, Elena [US DOE; View Inc; Loftness, Vivian [Carnegie Mellon Univ., Pittsburgh, PA (United States); Wang, Haopeng [Carnegie Mellon Univ., Pittsburgh, PA (United States); Mo, Yunjeong [Carnegie Mellon Univ., Pittsburgh, PA (United States); Wang, Ting [Carnegie Mellon Univ., Pittsburgh, PA (United States); Zhang, Chenlu [Carnegie Mellon Univ., Pittsburgh, PA (United States); Sharma, Shilpi [Carnegie Mellon; Stevens, Ivana [Carnegie Mellon Univ., Pittsburgh, PA (United States)

    2016-03-18

    The American Recovery and Reinvestment Act stimulus funding of 2009 for smart grid projects resulted in the tripling of smart meters deployment. In 2012, the Green Button initiative provided utility customers with access to their real-time1 energy usage. The availability of finely granular data provides an enormous potential for energy data analytics and energy benchmarking. The sheer volume of time-series utility data from a large number of buildings also poses challenges in data collection, quality control, and database management for rigorous and meaningful analyses. In this paper, we will describe a building portfolio-level data analytics tool for operational optimization, business investment and policy assessment using 15-minute to monthly intervals utility data. The analytics tool is developed on top of the U.S. Department of Energy’s Standard Energy Efficiency Data (SEED) platform, an open source software application that manages energy performance data of large groups of buildings. To support the significantly large volume of granular interval data, we integrated a parallel time-series database to the existing relational database. The time-series database improves on the current utility data input, focusing on real-time data collection, storage, analytics and data quality control. The fully integrated data platform supports APIs for utility apps development by third party software developers. These apps will provide actionable intelligence for building owners and facilities managers. Unlike a commercial system, this platform is an open source platform funded by the U.S. Government, accessible to the public, researchers and other developers, to support initiatives in reducing building energy consumption.

  13. Platform Innovations and System Integration for Unmanned Air, Land and Sea Vehicles Symposium. Technical Evaluation Report

    National Research Council Canada - National Science Library

    Decuypere, Roland; Selegan, David

    2007-01-01

    ...) of the Research and Technology Organization (RTO) of NATO organized a joint symposium on Platform Innovations and System Integration for Unmanned Air, Land and Sea Vehicles which met from 14-18 May 2007 in Florence Italy...

  14. SVIP-N 1.0: An integrated visualization platform for neutronics analysis

    International Nuclear Information System (INIS)

    Luo Yuetong; Long Pengcheng; Wu Guoyong; Zeng Qin; Hu Liqin; Zou Jun

    2010-01-01

    Post-processing is an important part of neutronics analysis, and SVIP-N 1.0 (scientific visualization integrated platform for neutronics analysis) is designed to ease post-processing of neutronics analysis through visualization technologies. Main capabilities of SVIP-N 1.0 include: (1) ability of manage neutronics analysis result; (2) ability to preprocess neutronics analysis result; (3) ability to visualization neutronics analysis result data in different way. The paper describes the system architecture and main features of SVIP-N, some advanced visualization used in SVIP-N 1.0 and some preliminary applications, such as ITER.

  15. Minilaparoscopic hysterectomy made easy: first report on alternative instrumentation and new integrated energy platform.

    Science.gov (United States)

    Ng, Ying Woo; Lim, Li Min; Fong, Yoke Fai

    2014-05-01

    Minilaparoscopy is an attractive approach for hysterectomy due to advantages such as reduced morbidities and enhanced cosmesis. However, it has not been popularized due to the lack of suitable instruments and high technical demand. We aim to highlight the first case of minilaparoscopic hysterectomy reported in Asia and the use of a new integrated energy platform, Thunderbeat. We would like to propose an alternative method of instrumentation, so as to improve the feasibility and safety of minilaparoscopic hysterectomy. The first minilaparoscopic hysterectomy in Singapore was successfully completed using the alternative instrumentation and new energy platform. There was no conversion or complication during the surgery. The patient recovered uneventfully. To our knowledge, this is the first report on the use of such alternative instrumentation. This approach in instrumentation and the new energy platform will improve the feasibility and speed of the surgery and ensure safety in our patients. © 2014 The Authors. Journal of Obstetrics and Gynaecology Research © 2014 Japan Society of Obstetrics and Gynecology.

  16. A commercial real-time manufacturing integration platform for the new control system on FTU

    International Nuclear Information System (INIS)

    Panella, M.; Bertocchi, A.; Bozzolan, V.; Buceti, G.; Centioli, C.; Imparato, A.; Mazza, G.; Torelli, C.; Vitale, V.

    1999-01-01

    In 1994 a working group was set up in Frascati to investigate how to build up a new control system for FTU (Frascati tokamak upgrade) considering the evolution in the information technology. Strong emphasis was placed on the use of standard solutions (be they de-facto or de-jure) and commercial platforms where-ever possible. This paper describes our operational experience with the new control system based on the commercial DEC BASEstar family of products. BASEstar is based on client/server computing technologies, providing an environment to collect, process, manage, distribute and integrate real time manufacturing data. UNIX, VMS, PC Win, OS-9 are integrated to handle hosts, PC, VME CPUs. A 4 GL programming language, CIMfast, has been used to handle via automatic procedures the tokamak discharge. X11 standard based mimics are available to display the plants status. A real flexibility of the whole system has been experience and the further use of the this system has been planned for the ITER DTP (divertor test platform). (orig.)

  17. A Platform of Constructivist Learning in Practice: Computer Literacy Integrated into Elementary School

    Directory of Open Access Journals (Sweden)

    Ivan Garcia

    2010-06-01

    Full Text Available In Mexico, the conventional teaching approach, when applied specifically to elementary school, seems to fall short of attaining the overall quality objective. The main consequence of this problem is when teachers are not sure that their students really understand the dynamic nature of concepts and mechanism since an early age, particularly in elementary school. This paper presents a pedagogical/technological platform, based on constructivism ideas, as a means of making the learning process in elementary school more efficient and interesting. The constructivist platform presented here uses graphical simulators developed for Web 2.0 as a support tool, creating a teaching and learning environment in which practical experiments can be undertaken as each topic is introduced and explained.

  18. Health Care Transformation Through Collaboration on Open-Source Informatics Projects: Integrating a Medical Applications Platform, Research Data Repository, and Patient Summarization

    Science.gov (United States)

    McCoy, Allison B; Wright, Adam; Wattanasin, Nich; Sittig, Dean F; Murphy, Shawn N

    2013-01-01

    Background The Strategic Health IT Advanced Research Projects (SHARP) program seeks to conquer well-understood challenges in medical informatics through breakthrough research. Two SHARP centers have found alignment in their methodological needs: (1) members of the National Center for Cognitive Informatics and Decision-making (NCCD) have developed knowledge bases to support problem-oriented summarizations of patient data, and (2) Substitutable Medical Apps, Reusable Technologies (SMART), which is a platform for reusable medical apps that can run on participating platforms connected to various electronic health records (EHR). Combining the work of these two centers will ensure wide dissemination of new methods for synthesized views of patient data. Informatics for Integrating Biology and the Bedside (i2b2) is an NIH-funded clinical research data repository platform in use at over 100 sites worldwide. By also working with a co-occurring initiative to SMART-enabling i2b2, we can confidently write one app that can be used extremely broadly. Objective Our goal was to facilitate development of intuitive, problem-oriented views of the patient record using NCCD knowledge bases that would run in any EHR. To do this, we developed a collaboration between the two SHARPs and an NIH center, i2b2. Methods First, we implemented collaborative tools to connect researchers at three institutions. Next, we developed a patient summarization app using the SMART platform and a previously validated NCCD problem-medication linkage knowledge base derived from the National Drug File-Reference Terminology (NDF-RT). Finally, to SMART-enable i2b2, we implemented two new Web service “cells” that expose the SMART application programming interface (API), and we made changes to the Web interface of i2b2 to host a “carousel” of SMART apps. Results We deployed our SMART-based, NDF-RT-derived patient summarization app in this SMART-i2b2 container. It displays a problem-oriented view of

  19. Health care transformation through collaboration on open-source informatics projects: integrating a medical applications platform, research data repository, and patient summarization.

    Science.gov (United States)

    Klann, Jeffrey G; McCoy, Allison B; Wright, Adam; Wattanasin, Nich; Sittig, Dean F; Murphy, Shawn N

    2013-05-30

    The Strategic Health IT Advanced Research Projects (SHARP) program seeks to conquer well-understood challenges in medical informatics through breakthrough research. Two SHARP centers have found alignment in their methodological needs: (1) members of the National Center for Cognitive Informatics and Decision-making (NCCD) have developed knowledge bases to support problem-oriented summarizations of patient data, and (2) Substitutable Medical Apps, Reusable Technologies (SMART), which is a platform for reusable medical apps that can run on participating platforms connected to various electronic health records (EHR). Combining the work of these two centers will ensure wide dissemination of new methods for synthesized views of patient data. Informatics for Integrating Biology and the Bedside (i2b2) is an NIH-funded clinical research data repository platform in use at over 100 sites worldwide. By also working with a co-occurring initiative to SMART-enabling i2b2, we can confidently write one app that can be used extremely broadly. Our goal was to facilitate development of intuitive, problem-oriented views of the patient record using NCCD knowledge bases that would run in any EHR. To do this, we developed a collaboration between the two SHARPs and an NIH center, i2b2. First, we implemented collaborative tools to connect researchers at three institutions. Next, we developed a patient summarization app using the SMART platform and a previously validated NCCD problem-medication linkage knowledge base derived from the National Drug File-Reference Terminology (NDF-RT). Finally, to SMART-enable i2b2, we implemented two new Web service "cells" that expose the SMART application programming interface (API), and we made changes to the Web interface of i2b2 to host a "carousel" of SMART apps. We deployed our SMART-based, NDF-RT-derived patient summarization app in this SMART-i2b2 container. It displays a problem-oriented view of medications and presents a line-graph display of

  20. OpenDrop: An Integrated Do-It-Yourself Platform for Personal Use of Biochips

    Directory of Open Access Journals (Sweden)

    Mirela Alistar

    2017-05-01

    Full Text Available Biochips, or digital labs-on-chip, are developed with the purpose of being used by laboratory technicians or biologists in laboratories or clinics. In this article, we expand this vision with the goal of enabling everyone, regardless of their expertise, to use biochips for their own personal purposes. We developed OpenDrop, an integrated electromicrofluidic platform that allows users to develop and program their own bio-applications. We address the main challenges that users may encounter: accessibility, bio-protocol design and interaction with microfluidics. OpenDrop consists of a do-it-yourself biochip, an automated software tool with visual interface and a detailed technique for at-home operations of microfluidics. We report on two years of use of OpenDrop, released as an open-source platform. Our platform attracted a highly diverse user base with participants originating from maker communities, academia and industry. Our findings show that 47% of attempts to replicate OpenDrop were successful, the main challenge remaining the assembly of the device. In terms of usability, the users managed to operate their platforms at home and are working on designing their own bio-applications. Our work provides a step towards a future in which everyone will be able to create microfluidic devices for their personal applications, thereby democratizing parts of health care.

  1. The Innovative Capabilities Of Digital Payment Platforms

    DEFF Research Database (Denmark)

    Kazan, Erol

    2015-01-01

    This study presents a model for studying the innovative capabilities of digital payment platforms in regards to open innovation integration and commercialization. We perceive digital platforms as layered modular IT artifacts, where platform governance and the configuration of platform layers impact...... the support for open innovation. The proposed model has been employed in a comparative case study between two digital payment platforms: Apple Pay and Google Wallet. The findings suggest that digital payment platforms make use of boundary resources to be highly integrative or integratable, which supports...... the intended conjoint commercialization efforts. Furthermore, the architectural design of digital platforms impacts the access to commercialization, resulting to an exclusion or inclusion strategy in accessing value opportunities. Our findings contribute to the open innovation and digital platform literature...

  2. Modification of Method for Solution of Direct Kinematic Problem for the Type of Platform Manipulators with Six Degrees of Freedom

    Directory of Open Access Journals (Sweden)

    A. L. Lapikov

    2014-01-01

    Full Text Available This paper considers creation of methods for research of multi-section manipulators of parallel structure. To solve this task it is necessary, firstly, to carry out generalization, systematization, and enhancement of existing models of platform manipulators with six degrees of freedom; secondly, it is necessary to modify previously suggested methods for solving the kinematic tasks for the specified type of manipulation mechanisms. The paper presents detailed domain analysis, describes major issues appearing in the course of research, and suggests basic methods of their solution. The paper demonstrates the necessity for modification of existing models through supplementing new parameters. Modification and generalization of the previously suggested method for solution of direct kinematic problem for the specified type of manipulators were carried out. Method for solution of this problem consists in establishing the dependence of functional relationship of Cartesian coordinates and orientation of the moving platform center on the values of generalized coordinates of manipulator (in case of platform manipulators, these are the lengths of telescopic legs connecting the base and the moving platform of the manipulator. The method is created in such a way that solution of direct kinematic problem results in finding of the analytical equation of the plane where the moving platform lies. The equation of the required plane is described through three points (attachment points of the moving platform joints. To define coordinate values of the joints, the system of nine non-linear equations is generated. It should be noted that the system of equations is composed of one-type equations with the same type of nonlinearity. The physical meaning of all the nine equations of the system is Euclidean distance between the points of the manipulator. The location and orientation of the manipulator are depicted as a homogenous transformation matrix. Vectors of translation

  3. Integrated method to optimize well connection and platform placement on a multi-reservoir scenario

    Energy Technology Data Exchange (ETDEWEB)

    Sousa, Sergio Henrique Guerra de; Madeira, Marcelo Gomes; Franca, Martha Salles [Halliburton, Rio de Janeiro, RJ (Brazil); Mota, Rosane Oliveira; Silva, Edilon Ribeiro da; King, Vanessa Pereira Spear [Petroleo Brasileiro S.A. (PETROBRAS), Rio de Janeiro, RJ (Brazil)

    2012-07-01

    This paper describes a workflow created to optimize the platform placement and well-platform connections on a multi reservoir scenario using an integrated reservoir simulator paired with an optimization engine. The proposed methodology describes how a new platform, being incorporated into a pre-existing asset, can be better used to develop newly-discovered fields, while helping increase the production of existing fields by sharing their production load. The sharing of production facilities is highly important in Brazilian offshore assets because of their high price (a few billion dollars per facility) and the fact that total production is usually limited to the installed capacity of liquid processing, which is an important constraint on high water-cut well production rates typical to this region. The case study asset used to present the workflow consists of two deep water oil fields, each one developed by its own production platform, and a newly-discovered field with strong aquifer support that will be entirely developed with a new production platform. Because this new field should not include injector wells owing to the strong aquifer presence, the idea is to consider reconnecting existing wells from the two pre-existing fields to better use the production resources. In this scenario, the platform location is an important optimization issue, as a balance between supporting the production of the planned wells on the new field and the production of re-routed wells from the existing fields must be reached to achieve improved overall asset production. If the new platform is too far away from any interconnected production well, pressure-drop issues along the pipeline might actually decrease production from the existing fields rather than augment it. The main contribution of this work is giving the reader insights on how to model and optimize these complex decisions to generate high-quality scenarios. (author)

  4. Integration of reconfigurable potentiometric electrochemical sensors into a digital microfluidic platform.

    Science.gov (United States)

    Farzbod, Ali; Moon, Hyejin

    2018-05-30

    This paper presents the demonstration of on-chip fabrication of a potassium-selective sensor array enabled by electrowetting on dielectric digital microfluidics for the first time. This demonstration proves the concept that electrochemical sensors can be seamlessly integrated with sample preparation units in a digital microfluidic platform. More significantly, the successful on-chip fabrication of a sensor array indicates that sensors become reconfigurable and have longer lifetime in a digital microfluidic platform. The on-chip fabrication of ion-selective electrodes includes electroplating Ag followed by forming AgCl layer by chemical oxidation and depositing a thin layer of desired polymer-based ion selective membrane on one of the sensor electrodes. In this study, potassium ionophores work as potassium ion channels and make the membrane selective to potassium ions. This selectiveness results in the voltage difference across the membrane layer, which is correlated with potassium ion concentration. The calibration curve of the fabricated potassium-selective electrode demonstrates the slope of 58 mV/dec for potassium concentration in KCl sample solutions and shows good agreement with the ideal Nernstian response. The proposed sensor platform is an outstanding candidate for a portable home-use for continuous monitoring of ions thanks to its advantages such as easy automation of sample preparation and detection processes, elongated sensor lifetime, minimal membrane and sample consumption, and user-definable/reconfigurable sensor array. Copyright © 2018 Elsevier B.V. All rights reserved.

  5. Miniaturized Integrated Platform for Electrical and Optical Monitoring of Cell Cultures

    Directory of Open Access Journals (Sweden)

    Costin Brasoveanu

    2012-08-01

    Full Text Available The following paper describes the design and functions of a miniaturized integrated platform for optical and electrical monitoring of cell cultures and the necessary steps in the fabrication and testing of a silicon microchip Micro ElectroMechanical Systems (MEMS-based technology for cell data recording, monitoring and stimulation. The silicon microchip consists of a MEMS machined device containing a shank of 240 μm width, 3 mm long and 50 μm thick and an enlarged area of 5 mm × 5 mm hosting the pads for electrical connections. Ten platinum electrodes and five sensors are placed on the shank and are connected with the external electronics through the pads. The sensors aim to monitor the pH, the temperature and the impedance of the cell culture. The electrodes are bidirectional and can be used both for electrical potential recording and stimulation of cells. The fabrication steps are presented, along with the electrical and optical characterization of the system. The target of the research is to develop a new and reconfigurable platform according to the particular applications needs, as a tool for the biologist, chemists and medical doctors working is the field of cell culture monitoring in terms of growth, maintenance conditions, reaction to electrical or chemical stimulation (drugs, toxicants, etc.. HaCaT (Immortalised Human Keratinocyte cell culture has been used for demonstration purposes in order to provide information on the platform electrical and optical functions.

  6. GeNNet: an integrated platform for unifying scientific workflows and graph databases for transcriptome data analysis

    Directory of Open Access Journals (Sweden)

    Raquel L. Costa

    2017-07-01

    Full Text Available There are many steps in analyzing transcriptome data, from the acquisition of raw data to the selection of a subset of representative genes that explain a scientific hypothesis. The data produced can be represented as networks of interactions among genes and these may additionally be integrated with other biological databases, such as Protein-Protein Interactions, transcription factors and gene annotation. However, the results of these analyses remain fragmented, imposing difficulties, either for posterior inspection of results, or for meta-analysis by the incorporation of new related data. Integrating databases and tools into scientific workflows, orchestrating their execution, and managing the resulting data and its respective metadata are challenging tasks. Additionally, a great amount of effort is equally required to run in-silico experiments to structure and compose the information as needed for analysis. Different programs may need to be applied and different files are produced during the experiment cycle. In this context, the availability of a platform supporting experiment execution is paramount. We present GeNNet, an integrated transcriptome analysis platform that unifies scientific workflows with graph databases for selecting relevant genes according to the evaluated biological systems. It includes GeNNet-Wf, a scientific workflow that pre-loads biological data, pre-processes raw microarray data and conducts a series of analyses including normalization, differential expression inference, clusterization and gene set enrichment analysis. A user-friendly web interface, GeNNet-Web, allows for setting parameters, executing, and visualizing the results of GeNNet-Wf executions. To demonstrate the features of GeNNet, we performed case studies with data retrieved from GEO, particularly using a single-factor experiment in different analysis scenarios. As a result, we obtained differentially expressed genes for which biological functions were

  7. A CLOUD-BASED PLATFORM SUPPORTING GEOSPATIAL COLLABORATION FOR GIS EDUCATION

    Directory of Open Access Journals (Sweden)

    X. Cheng

    2015-05-01

    Full Text Available GIS-related education needs support of geo-data and geospatial software. Although there are large amount of geographic information resources distributed on the web, the discovery, process and integration of these resources are still unsolved. Researchers and teachers always searched geo-data by common search engines but results were not satisfied. They also spent much money and energy on purchase and maintenance of various kinds of geospatial software. Aimed at these problems, a cloud-based geospatial collaboration platform called GeoSquare was designed and implemented. The platform serves as a geoportal encouraging geospatial data, information, and knowledge sharing through highly interactive and expressive graphic interfaces. Researchers and teachers can solve their problems effectively in this one-stop solution. Functions, specific design and implementation details are presented in this paper. Site of GeoSquare is: http://geosquare.tianditu.com/

  8. a Cloud-Based Platform Supporting Geospatial Collaboration for GIS Education

    Science.gov (United States)

    Cheng, X.; Gui, Z.; Hu, K.; Gao, S.; Shen, P.; Wu, H.

    2015-05-01

    GIS-related education needs support of geo-data and geospatial software. Although there are large amount of geographic information resources distributed on the web, the discovery, process and integration of these resources are still unsolved. Researchers and teachers always searched geo-data by common search engines but results were not satisfied. They also spent much money and energy on purchase and maintenance of various kinds of geospatial software. Aimed at these problems, a cloud-based geospatial collaboration platform called GeoSquare was designed and implemented. The platform serves as a geoportal encouraging geospatial data, information, and knowledge sharing through highly interactive and expressive graphic interfaces. Researchers and teachers can solve their problems effectively in this one-stop solution. Functions, specific design and implementation details are presented in this paper. Site of GeoSquare is: http://geosquare.tianditu.com/

  9. Launching platforms for user-generated content

    OpenAIRE

    Batista, Guilherme Luís Caroço

    2015-01-01

    Field lab: Entrepreneurial and innovative ventures This paper intends to discuss and absorb the Best Practices employed by successful User- Generated Content (UGC)1 platforms and constitute a guide on how to launch a platform without having a cyclical lack of content and users. Research shows that companies have resorted to integration with mature UGC platforms, and providing content by themselves, in an initial state. I conclude that integration possibilities should be explore...

  10. A multi-landing pad DNA integration platform for mammalian cell engineering

    Science.gov (United States)

    Gaidukov, Leonid; Wroblewska, Liliana; Teague, Brian; Nelson, Tom; Zhang, Xin; Liu, Yan; Jagtap, Kalpana; Mamo, Selamawit; Tseng, Wen Allen; Lowe, Alexis; Das, Jishnu; Bandara, Kalpanie; Baijuraj, Swetha; Summers, Nevin M; Zhang, Lin; Weiss, Ron

    2018-01-01

    Abstract Engineering mammalian cell lines that stably express many transgenes requires the precise insertion of large amounts of heterologous DNA into well-characterized genomic loci, but current methods are limited. To facilitate reliable large-scale engineering of CHO cells, we identified 21 novel genomic sites that supported stable long-term expression of transgenes, and then constructed cell lines containing one, two or three ‘landing pad’ recombination sites at selected loci. By using a highly efficient BxB1 recombinase along with different selection markers at each site, we directed recombinase-mediated insertion of heterologous DNA to selected sites, including targeting all three with a single transfection. We used this method to controllably integrate up to nine copies of a monoclonal antibody, representing about 100 kb of heterologous DNA in 21 transcriptional units. Because the integration was targeted to pre-validated loci, recombinant protein expression remained stable for weeks and additional copies of the antibody cassette in the integrated payload resulted in a linear increase in antibody expression. Overall, this multi-copy site-specific integration platform allows for controllable and reproducible insertion of large amounts of DNA into stable genomic sites, which has broad applications for mammalian synthetic biology, recombinant protein production and biomanufacturing. PMID:29617873

  11. HASILT: An intelligent software platform for HAZOP, LOPA, SRS and SIL verification

    International Nuclear Information System (INIS)

    Cui, Lin; Shu, Yidan; Wang, Zhaohui; Zhao, Jinsong; Qiu, Tong; Sun, Wenyong; Wei, Zhenqiang

    2012-01-01

    Incomplete process hazard analysis (PHA) and poor knowledge management have been two major reasons that have caused numerous lamentable disasters in the chemical process industry (CPI). To improve PHA quality, a new integration framework that combines HAZOP, layer of protection analysis (LOPA), safety requirements specification (SRS) and safety integrity level (SIL) validation is proposed in this paper. To facilitate the integrated work flow and improve the relevant knowledge management, an intelligent software platform named HASILT has been developed by our research team. Its key components and functions are described in this paper. Furthermore, since the platform keeps all history data in a central case base and case-based reasoning is used to automatically retrieve similar old cases for helping resolve new problems, a recall opportunity is created to reduce information loss which has been cited many times as a common root cause in investigations of accidents.

  12. High Level of Integration in Integrated Disease Management Leads to Higher Usage in the e-Vita Study: Self-Management of Chronic Obstructive Pulmonary Disease With Web-Based Platforms in a Parallel Cohort Design.

    Science.gov (United States)

    Talboom-Kamp, Esther Pwa; Verdijk, Noortje A; Kasteleyn, Marise J; Harmans, Lara M; Talboom, Irvin Jsh; Numans, Mattijs E; Chavannes, Niels H

    2017-05-31

    Worldwide, nearly 3 million people die of chronic obstructive pulmonary disease (COPD) every year. Integrated disease management (IDM) improves disease-specific quality of life and exercise capacity for people with COPD, but can also reduce hospital admissions and hospital days. Self-management of COPD through eHealth interventions has shown to be an effective method to improve the quality and efficiency of IDM in several settings, but it remains unknown which factors influence usage of eHealth and change in behavior of patients. Our study, e-Vita COPD, compares different levels of integration of Web-based self-management platforms in IDM in three primary care settings. The main aim of this study is to analyze the factors that successfully promote the use of a self-management platform for COPD patients. The e-Vita COPD study compares three different approaches to incorporating eHealth via Web-based self-management platforms into IDM of COPD using a parallel cohort design. Three groups integrated the platforms to different levels. In groups 1 (high integration) and 2 (medium integration), randomization was performed to two levels of personal assistance for patients (high and low assistance); in group 3 there was no integration into disease management (none integration). Every visit to the e-Vita and Zorgdraad COPD Web platforms was tracked objectively by collecting log data (sessions and services). At the first log-in, patients completed a baseline questionnaire. Baseline characteristics were automatically extracted from the log files including age, gender, education level, scores on the Clinical COPD Questionnaire (CCQ), dyspnea scale (MRC), and quality of life questionnaire (EQ5D). To predict the use of the platforms, multiple linear regression analyses for the different independent variables were performed: integration in IDM (high, medium, none), personal assistance for the participants (high vs low), educational level, and self-efficacy level (General Self

  13. Bio-jETI: a service integration, design, and provisioning platform for orchestrated bioinformatics processes.

    Science.gov (United States)

    Margaria, Tiziana; Kubczak, Christian; Steffen, Bernhard

    2008-04-25

    With Bio-jETI, we introduce a service platform for interdisciplinary work on biological application domains and illustrate its use in a concrete application concerning statistical data processing in R and xcms for an LC/MS analysis of FAAH gene knockout. Bio-jETI uses the jABC environment for service-oriented modeling and design as a graphical process modeling tool and the jETI service integration technology for remote tool execution. As a service definition and provisioning platform, Bio-jETI has the potential to become a core technology in interdisciplinary service orchestration and technology transfer. Domain experts, like biologists not trained in computer science, directly define complex service orchestrations as process models and use efficient and complex bioinformatics tools in a simple and intuitive way.

  14. An integrated platform for gas-diffusion separation and electrochemical determination of ethanol on fermentation broths

    Energy Technology Data Exchange (ETDEWEB)

    Giordano, Gabriela Furlan [Microfabrication Laboratory, Brazilian Nanotechnology National Laboratory (LNNano), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, SP 13083-970 (Brazil); Department of Analytical Chemistry, Institute of Chemistry – UNICAMP, Campinas, SP 13083-970 (Brazil); National Institute of Science and Technology of Bioanalytics, Institute of Chemistry – UNICAMP, Campinas, SP 13083-970 (Brazil); Vieira, Luis Carlos Silveira; Gobbi, Angelo Luiz [Microfabrication Laboratory, Brazilian Nanotechnology National Laboratory (LNNano), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, SP 13083-970 (Brazil); Lima, Renato Sousa [Microfabrication Laboratory, Brazilian Nanotechnology National Laboratory (LNNano), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, SP 13083-970 (Brazil); Department of Analytical Chemistry, Institute of Chemistry – UNICAMP, Campinas, SP 13083-970 (Brazil); National Institute of Science and Technology of Bioanalytics, Institute of Chemistry – UNICAMP, Campinas, SP 13083-970 (Brazil); Kubota, Lauro Tatsuo, E-mail: kubota@iqm.unicamp.br [Department of Analytical Chemistry, Institute of Chemistry – UNICAMP, Campinas, SP 13083-970 (Brazil); National Institute of Science and Technology of Bioanalytics, Institute of Chemistry – UNICAMP, Campinas, SP 13083-970 (Brazil)

    2015-05-22

    Highlights: • Integrated platform was developed to determine ethanol in fermentation broths. • The designed system integrates gas diffusion separation with voltammetric detection. • Detector relied on Ni(OH){sub 2}-modified electrode stabilized by Co{sup 2+} and Cd{sup 2+} insertion. • Separation was made by PTFE membrane separating sample from electrolyte (receptor). • Despite the sample complexity, accurate tests were achieved by direct interpolation. - Abstract: An integrated platform was developed for point-of-use determination of ethanol in sugar cane fermentation broths. Such analysis is important because ethanol reduces its fuel production efficiency by altering the alcoholic fermentation step when in excess. The custom-designed platform integrates gas diffusion separation with voltammetric detection in a single analysis module. The detector relied on a Ni(OH){sub 2}-modified electrode. It was stabilized by uniformly depositing cobalt and cadmium hydroxides as shown by XPS measurements. Such tests were in accordance with the hypothesis related to stabilization of the Ni(OH){sub 2} structure by insertion of Co{sup 2+} and Cd{sup 2+} ions in this structure. The separation step, in turn, was based on a hydrophobic PTFE membrane, which separates the sample from receptor solution (electrolyte) where the electrodes were placed. Parameters of limit of detection and analytical sensitivity were estimated to be 0.2% v/v and 2.90 μA % (v/v){sup −1}, respectively. Samples of fermentation broth were analyzed by both standard addition method and direct interpolation in saline medium based-analytical curve. In this case, the saline solution exhibited ionic strength similar to those of the samples intended to surpass the tonometry colligative effect of the samples over analyte concentration data by attributing the reduction in quantity of diffused ethanol vapor majorly to the electrolyte. The approach of analytical curve provided rapid, simple and accurate

  15. Iterative algorithm for the volume integral method for magnetostatics problems

    International Nuclear Information System (INIS)

    Pasciak, J.E.

    1980-11-01

    Volume integral methods for solving nonlinear magnetostatics problems are considered in this paper. The integral method is discretized by a Galerkin technique. Estimates are given which show that the linearized problems are well conditioned and hence easily solved using iterative techniques. Comparisons of iterative algorithms with the elimination method of GFUN3D shows that the iterative method gives an order of magnitude improvement in computational time as well as memory requirements for large problems. Computational experiments for a test problem as well as a double layer dipole magnet are given. Error estimates for the linearized problem are also derived

  16. Systematic Integration of Innovation in Process Improvement Projects Using the Enhanced Sigma-TRIZ Algorithm and Its Effective Use by Means of a Knowledge Management Software Platform

    Directory of Open Access Journals (Sweden)

    Mircea FULEA

    2009-01-01

    Full Text Available In an evolving, highly turbulent and uncertain socio-economic environment, organizations must consider strategies of systematic and continuous integration of innovation within their business systems, as a fundamental condition for sustainable development. Adequate methodologies are required in this respect. A mature framework for integrating innovative problem solving approaches within business process improvement methodologies is proposed in this paper. It considers a TRIZ-centred algorithm in the improvement phase of the DMAIC methodology. The new tool is called enhanced sigma-TRIZ. A case study reveals the practical application of the proposed methodology. The integration of enhanced sigma-TRIZ within a knowledge management software platform (KMSP is further described. Specific developments to support processes of knowledge creation, knowledge storage and retrieval, knowledge transfer and knowledge application in a friendly and effective way within the KMSP are also highlighted.

  17. The Riesz-Radon-Fréchet problem of characterization of integrals

    Science.gov (United States)

    Zakharov, Valerii K.; Mikhalev, Aleksandr V.; Rodionov, Timofey V.

    2010-11-01

    This paper is a survey of results on characterizing integrals as linear functionals. It starts from the familiar result of F. Riesz (1909) on integral representation of bounded linear functionals by Riemann-Stieltjes integrals on a closed interval, and is directly connected with Radon's famous theorem (1913) on integral representation of bounded linear functionals by Lebesgue integrals on a compact subset of {R}^n. After the works of Radon, Fréchet, and Hausdorff, the problem of characterizing integrals as linear functionals took the particular form of the problem of extending Radon's theorem from {R}^n to more general topological spaces with Radon measures. This problem turned out to be difficult, and its solution has a long and rich history. Therefore, it is natural to call it the Riesz-Radon-Fréchet problem of characterization of integrals. Important stages of its solution are associated with such eminent mathematicians as Banach (1937-1938), Saks (1937-1938), Kakutani (1941), Halmos (1950), Hewitt (1952), Edwards (1953), Prokhorov (1956), Bourbaki (1969), and others. Essential ideas and technical tools were developed by A.D. Alexandrov (1940-1943), Stone (1948-1949), Fremlin (1974), and others. Most of this paper is devoted to the contemporary stage of the solution of the problem, connected with papers of König (1995-2008), Zakharov and Mikhalev (1997-2009), and others. The general solution of the problem is presented in the form of a parametric theorem on characterization of integrals which directly implies the characterization theorems of the indicated authors. Bibliography: 60 titles.

  18. Massively Parallel, Molecular Analysis Platform Developed Using a CMOS Integrated Circuit With Biological Nanopores

    Science.gov (United States)

    Roever, Stefan

    2012-01-01

    A massively parallel, low cost molecular analysis platform will dramatically change the nature of protein, molecular and genomics research, DNA sequencing, and ultimately, molecular diagnostics. An integrated circuit (IC) with 264 sensors was fabricated using standard CMOS semiconductor processing technology. Each of these sensors is individually controlled with precision analog circuitry and is capable of single molecule measurements. Under electronic and software control, the IC was used to demonstrate the feasibility of creating and detecting lipid bilayers and biological nanopores using wild type α-hemolysin. The ability to dynamically create bilayers over each of the sensors will greatly accelerate pore development and pore mutation analysis. In addition, the noise performance of the IC was measured to be 30fA(rms). With this noise performance, single base detection of DNA was demonstrated using α-hemolysin. The data shows that a single molecule, electrical detection platform using biological nanopores can be operationalized and can ultimately scale to millions of sensors. Such a massively parallel platform will revolutionize molecular analysis and will completely change the field of molecular diagnostics in the future.

  19. Numerical method of singular problems on singular integrals

    International Nuclear Information System (INIS)

    Zhao Huaiguo; Mou Zongze

    1992-02-01

    As first part on the numerical research of singular problems, a numerical method is proposed for singular integrals. It is shown that the procedure is quite powerful for solving physics calculation with singularity such as the plasma dispersion function. Useful quadrature formulas for some class of the singular integrals are derived. In general, integrals with more complex singularities can be dealt by this method easily

  20. Integrated assessment of the global warming problem. A decision-analytical approach

    International Nuclear Information System (INIS)

    Van Lenthe, J.; Hendrickx, L.; Vlek, C.A.J.

    1995-01-01

    The project on the title subject aims at developing a policy-oriented methodology for the integrated assessment of the global warming problem. Decision analysis in general and influence diagrams in particular appear to constitute an appropriate integrated assessment methodology. The influence-diagram approach is illustrated at a preliminary integrated modeling of the global warming problem. In next stages of the research, attention will be shifted from the methodology of integrated assessment to the contents of integrated models. 4 figs., 5 refs

  1. Integrated assessment of the global warming problem: A decision-analytical approach

    International Nuclear Information System (INIS)

    Van Lenthe, J.; Hendrickx, L.; Vlek, C.A.J.

    1994-12-01

    The multi-disciplinary character of the global warming problem asks for an integrated assessment approach for ordering and combining the various physical, ecological, economical, and sociological results. The Netherlands initiated their own National Research Program (NRP) on Global Air Pollution and Climate Change (NRP). The first phase (NRP-1) identified the integration theme as one of five central research themes. The second phase (NRP-2) shows a growing concern for integrated assessment issues. The current two-year research project 'Characterizing the risks: a comparative analysis of the risks of global warming and of relevant policy options, which started in September 1993, comes under the integrated assessment part of the Dutch NRP. The first part of the interim report describes the search for an integrated assessment methodology. It starts with emphasizing the need for integrated assessment at a relatively high level of aggregation and from a policy point of view. The conclusion will be that a decision-analytical approach might fit the purpose of a policy-oriented integrated modeling of the global warming problem. The discussion proceeds with an account on decision analysis and its explicit incorporation and analysis of uncertainty. Then influence diagrams, a relatively recent development in decision analysis, are introduced as a useful decision-analytical approach for integrated assessment. Finally, a software environment for creating and analyzing complex influence diagram models is discussed. The second part of the interim report provides a first, provisional integrated modeling of the global warming problem, emphasizing on the illustration of the decision-analytical approach. Major problem elements are identified and an initial problem structure is developed. The problem structure is described in terms of hierarchical influence diagrams. At some places the qualitative structure is filled with quantitative data

  2. RELEVANT PROBLEMS OF UKRAINE’S INTEGRATION INTO GLOBAL ECONOMY

    Directory of Open Access Journals (Sweden)

    Yevheniia Duliba

    2017-12-01

    Full Text Available The purpose of this research is to study the main problems that prevent Ukraine from integrating into the global economy and to determine correct focuses of the foreign economic policy of Ukraine against the background of strengthening of globalization tendencies throughout the world. The bases of this research are bases of business development of the foreign economic policy of Ukraine and improvement of Ukrainian economy against the background of international integration. At the heart of the research methodology is a dialectical method of scientific knowledge and, besides, special methods of research based on modern scientific bases of economic, management and related to them knowledge: economic and statistic method – for the assessment of the modern state of foreign trade and investment activity of Ukraine; method of analysis and synthesis – for the determination of tendencies of development of integration processed in Ukraine; comparative analysis – for comparison of information concerning development of specific indicators of foreign economic activities in Ukraine. Results. As a result of research, the main blocks of problems, which impede the integration of Ukraine into the global economy, and requirements for their complex solution are determined. Besides, interdependence and interdetermination of problems, which impede the integration of Ukraine into the global economy, and requirements for their complex solution are explained. Political and legal, economic, sociocultural, and infrastructural preconditions that are necessary for effective integration of Ukraine into the global economy are highlighted. Practical implications. Analysis of the existing problems related to the actual economy, investments, innovation processes gives the possibility to determine the vector of development of Ukraine’s economy taking to account recommendations concerning its improvement for the purposes of integration into global economy. Value

  3. OTEC platform configuration and integration study. Volume I. Systems engineering and integration. Final report

    Energy Technology Data Exchange (ETDEWEB)

    None

    1978-04-01

    The economic success of an Ocean Thermal Energy Conversion (OTEC) system is highly dependent on a platform which provides adequate support for the power system, accommodates reliably the cold water pipe, and is most cost effective. The results of a study conducted for the Department of Energy to assess six generic types of platforms to determine the most satisfactory platform for severl potential sites are presented. The six platform configurations are ship, circular barge, semi-submersible, Tuned Sphere, submersible, and spar. These represent directional and symmetric types of platforms which operate on the surface, at the interface, and submerged. The five sites for this study were primarily New Orleans, Keahole Point (Hawaii), Brazil, and secondarily Key West and Puerto Rico. Electrical transmission of energy by submarine cable is the planned form of energy transmission for all sites except Brazil, where chemical conversion is to be the method of transmission. This study is devoted to the platform (or ocean systems) of the OTEC plant which is chiefly comprised of the hull and structure, the seawater system, the position control system, and miscellaneous support/assembly systems. The principal elements in the work breakdown structure for the commercial plants are presented. The assessment of the six platform configurations was conducted utilizing a baseline plan (100-MW(e) (Net)) and site (New Orleans) with variations from the baseline to cover the range of interested platforms and sites.

  4. University technology platform of anticipatory learning

    Directory of Open Access Journals (Sweden)

    Leonid Davidovich Gitelman

    2016-03-01

    Full Text Available The innovative development sets large-scale and challenging tasks, which need to be addressed in the lack-of-knowledge conditions and require the coordination and integration of numerous expert structures, which are scattered around the world and have different status and competencies. One of the mechanisms of integrating the partners’ intellectual and financial resources is provided by the technology platforms. The article discusses the nature and functions of technology platforms and analyzes the experience of their application in different countries with a special emphasis on universities. The article gives an overview of the various interpretations of technology platform concepts. It also describes the development and implementation of the technological platform at the Ural Federal University (research and education centre ‘ENGEC’, which was targeted at organizing anticipatory learning in the sphere of energy engineering and high-tech industries; its mechanism and role in improving different university activities and processes are shown. This platform is based on the original methodology ‘Integrated System of Consulting, Training, and Transformation’ (ISCT, which includes authentic methods and technologies, which are used in the educational process. A significant advantage of this methodology is that it can be applied in university education as well as in corporate training integrated with innovative activities.

  5. Path integral solution of the Dirichlet problem

    International Nuclear Information System (INIS)

    LaChapelle, J.

    1997-01-01

    A scheme for functional integration developed by Cartier/DeWitt-Morette is first reviewed and then employed to construct the path integral representation for the solution of the Dirichlet problem in terms of first exit time. The path integral solution is then applied to calculate the fixed-energy point-to-point transition amplitude both in configuration and phase space. The path integral solution can also be derived using physical principles based on Feynman close-quote s original reasoning. We check that the Fourier transform in energy of the fixed-energy point-to-point transition amplitude gives the well known time-dependent transition amplitude, and calculate the WKB approximation. copyright 1997 Academic Press, Inc

  6. An Experimentation Platform for On-Chip Integration of Analog Neural Networks: A Pathway to Trusted and Robust Analog/RF ICs.

    Science.gov (United States)

    Maliuk, Dzmitry; Makris, Yiorgos

    2015-08-01

    We discuss the design of an experimentation platform intended for prototyping low-cost analog neural networks for on-chip integration with analog/RF circuits. The objective of such integration is to support various tasks, such as self-test, self-tuning, and trust/aging monitoring, which require classification of analog measurements obtained from on-chip sensors. Particular emphasis is given to cost-efficient implementation reflected in: 1) low energy and area budgets of circuits dedicated to neural networks; 2) robust learning in presence of analog inaccuracies; and 3) long-term retention of learned functionality. Our chip consists of a reconfigurable array of synapses and neurons operating below threshold and featuring sub-μW power consumption. The synapse circuits employ dual-mode weight storage: 1) a dynamic mode, for fast bidirectional weight updates during training and 2) a nonvolatile mode, for permanent storage of learned functionality. We discuss a robust learning strategy, and we evaluate the system performance on several benchmark problems, such as the XOR2-6 and two-spirals classification tasks.

  7. Combining a Multi-Agent System and Communication Middleware for Smart Home Control: A Universal Control Platform Architecture.

    Science.gov (United States)

    Zheng, Song; Zhang, Qi; Zheng, Rong; Huang, Bi-Qin; Song, Yi-Lin; Chen, Xin-Chu

    2017-09-16

    In recent years, the smart home field has gained wide attention for its broad application prospects. However, families using smart home systems must usually adopt various heterogeneous smart devices, including sensors and devices, which makes it more difficult to manage and control their home system. How to design a unified control platform to deal with the collaborative control problem of heterogeneous smart devices is one of the greatest challenges in the current smart home field. The main contribution of this paper is to propose a universal smart home control platform architecture (IAPhome) based on a multi-agent system and communication middleware, which shows significant adaptability and advantages in many aspects, including heterogeneous devices connectivity, collaborative control, human-computer interaction and user self-management. The communication middleware is an important foundation to design and implement this architecture which makes it possible to integrate heterogeneous smart devices in a flexible way. A concrete method of applying the multi-agent software technique to solve the integrated control problem of the smart home system is also presented. The proposed platform architecture has been tested in a real smart home environment, and the results indicate that the effectiveness of our approach for solving the collaborative control problem of different smart devices.

  8. Combining a Multi-Agent System and Communication Middleware for Smart Home Control: A Universal Control Platform Architecture

    Science.gov (United States)

    Zheng, Song; Zhang, Qi; Zheng, Rong; Huang, Bi-Qin; Song, Yi-Lin; Chen, Xin-Chu

    2017-01-01

    In recent years, the smart home field has gained wide attention for its broad application prospects. However, families using smart home systems must usually adopt various heterogeneous smart devices, including sensors and devices, which makes it more difficult to manage and control their home system. How to design a unified control platform to deal with the collaborative control problem of heterogeneous smart devices is one of the greatest challenges in the current smart home field. The main contribution of this paper is to propose a universal smart home control platform architecture (IAPhome) based on a multi-agent system and communication middleware, which shows significant adaptability and advantages in many aspects, including heterogeneous devices connectivity, collaborative control, human-computer interaction and user self-management. The communication middleware is an important foundation to design and implement this architecture which makes it possible to integrate heterogeneous smart devices in a flexible way. A concrete method of applying the multi-agent software technique to solve the integrated control problem of the smart home system is also presented. The proposed platform architecture has been tested in a real smart home environment, and the results indicate that the effectiveness of our approach for solving the collaborative control problem of different smart devices. PMID:28926957

  9. Combining a Multi-Agent System and Communication Middleware for Smart Home Control: A Universal Control Platform Architecture

    Directory of Open Access Journals (Sweden)

    Song Zheng

    2017-09-01

    Full Text Available In recent years, the smart home field has gained wide attention for its broad application prospects. However, families using smart home systems must usually adopt various heterogeneous smart devices, including sensors and devices, which makes it more difficult to manage and control their home system. How to design a unified control platform to deal with the collaborative control problem of heterogeneous smart devices is one of the greatest challenges in the current smart home field. The main contribution of this paper is to propose a universal smart home control platform architecture (IAPhome based on a multi-agent system and communication middleware, which shows significant adaptability and advantages in many aspects, including heterogeneous devices connectivity, collaborative control, human-computer interaction and user self-management. The communication middleware is an important foundation to design and implement this architecture which makes it possible to integrate heterogeneous smart devices in a flexible way. A concrete method of applying the multi-agent software technique to solve the integrated control problem of the smart home system is also presented. The proposed platform architecture has been tested in a real smart home environment, and the results indicate that the effectiveness of our approach for solving the collaborative control problem of different smart devices.

  10. Quality control of next-generation sequencing library through an integrative digital microfluidic platform.

    Science.gov (United States)

    Thaitrong, Numrin; Kim, Hanyoup; Renzi, Ronald F; Bartsch, Michael S; Meagher, Robert J; Patel, Kamlesh D

    2012-12-01

    We have developed an automated quality control (QC) platform for next-generation sequencing (NGS) library characterization by integrating a droplet-based digital microfluidic (DMF) system with a capillary-based reagent delivery unit and a quantitative CE module. Using an in-plane capillary-DMF interface, a prepared sample droplet was actuated into position between the ground electrode and the inlet of the separation capillary to complete the circuit for an electrokinetic injection. Using a DNA ladder as an internal standard, the CE module with a compact LIF detector was capable of detecting dsDNA in the range of 5-100 pg/μL, suitable for the amount of DNA required by the Illumina Genome Analyzer sequencing platform. This DMF-CE platform consumes tenfold less sample volume than the current Agilent BioAnalyzer QC technique, preserving precious sample while providing necessary sensitivity and accuracy for optimal sequencing performance. The ability of this microfluidic system to validate NGS library preparation was demonstrated by examining the effects of limited-cycle PCR amplification on the size distribution and the yield of Illumina-compatible libraries, demonstrating that as few as ten cycles of PCR bias the size distribution of the library toward undesirable larger fragments. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  11. Six-degree-of-freedom active vibration isolation using a Stewart platform mechanism

    Science.gov (United States)

    Geng, Zheng; Haynes, Leonard S.

    1993-01-01

    The design and control problems of a class of multidegree-of-freedom vibration isolation systems (VISs) based on a Stewart platform mechanism are studied. A prototype of a six-degree-of-freedom VIS for precision control of a wide range of space-based structures implemented in Intelligent Automation, Inc. is described. The feasibility of using a Stewart platform to achieve 6-degree-of-freedom vibration control in space applications is shown. A new Terfenol-D actuator characterized by significantly longer stroke than any commercially available Terfenol-D actuator and direct flux and strain sensors integral to the actuator is described.

  12. Integration Between SCORM Learning Objects and the CIEMAT Virtual Elearning Platform; Integracion de Objetos de Aprendizaje SCORM con la Plataforma de Ensenanza Virtual del CIEMAT

    Energy Technology Data Exchange (ETDEWEB)

    Bailador Ferreras, M A; Troiani, S; Gonzalez Giralda, C; Llorente Herranz, C; Marco Arboli, M L

    2010-08-06

    New information and communications technologies have made a major contribution in the way of understanding the training needs, which have been involved in the change from the traditional teaching to the use of virtual learning platforms. Thus, Ciemat, has installed a virtual platform for education, in particular MOODLE in which have been installed some virtual contents developed with Flash. The next necessary step has been how to integrate the contents with the MOODLE virtual platform, following the aim to know the assessment for learning tracking of the learners. This document provides the technological facts for the integration of the flash virtual contents and the virtual platform in order to achieve the training process is efficiently evaluated. (Author) 5 refs.

  13. A survey of open problems in symplectic integration

    Energy Technology Data Exchange (ETDEWEB)

    McLachlan, R.I. [Univ. of Colorado, Boulder, CO (United States); Scovel, C. [Los Alamos National Lab., NM (United States)

    1993-10-15

    In the past few years there has been a substantial amount of research on symplectic integration. The subject is only part of a program concerned with numerically preserving a system`s inherent geometrical structures. Volume preservation, reversibility, local conservation laws for elliptic equations, and systems with integral invariants are but a few examples of such invariant structures. In many cases one requires a numerical method to stay in the smallest possible appropriate group of phase space maps. It is not the authors` opinion that symplecticity, for example, automatically makes a numerical method superior to all others, but it is their opinion that it should be taken seriously and that a conscious, informed decision be made in that regard. The authors present here a survey of open problems in symplectic integration, including other problems from the larger program. This is not intended as a review of symplectic integration and is naturally derived from the authors` own research interests. At present, this survey is incomplete, but the authors hope the help of the colleagues to be able to include in the proceedings of this conference a more comprehensive survey. Many of the problems mentioned here call for numerical experimentation, some for application of suggested but untested methods, some for new methods, and some for theorems, Some envisage large research programs.

  14. Integrated nanotechnology platform for tumor-targeted multimodal imaging and therapeutic cargo release.

    Science.gov (United States)

    Hosoya, Hitomi; Dobroff, Andrey S; Driessen, Wouter H P; Cristini, Vittorio; Brinker, Lina M; Staquicini, Fernanda I; Cardó-Vila, Marina; D'Angelo, Sara; Ferrara, Fortunato; Proneth, Bettina; Lin, Yu-Shen; Dunphy, Darren R; Dogra, Prashant; Melancon, Marites P; Stafford, R Jason; Miyazono, Kohei; Gelovani, Juri G; Kataoka, Kazunori; Brinker, C Jeffrey; Sidman, Richard L; Arap, Wadih; Pasqualini, Renata

    2016-02-16

    A major challenge of targeted molecular imaging and drug delivery in cancer is establishing a functional combination of ligand-directed cargo with a triggered release system. Here we develop a hydrogel-based nanotechnology platform that integrates tumor targeting, photon-to-heat conversion, and triggered drug delivery within a single nanostructure to enable multimodal imaging and controlled release of therapeutic cargo. In proof-of-concept experiments, we show a broad range of ligand peptide-based applications with phage particles, heat-sensitive liposomes, or mesoporous silica nanoparticles that self-assemble into a hydrogel for tumor-targeted drug delivery. Because nanoparticles pack densely within the nanocarrier, their surface plasmon resonance shifts to near-infrared, thereby enabling a laser-mediated photothermal mechanism of cargo release. We demonstrate both noninvasive imaging and targeted drug delivery in preclinical mouse models of breast and prostate cancer. Finally, we applied mathematical modeling to predict and confirm tumor targeting and drug delivery. These results are meaningful steps toward the design and initial translation of an enabling nanotechnology platform with potential for broad clinical applications.

  15. From childhood adversity to problem behaviors: Role of psychological and structural social integration.

    Science.gov (United States)

    Chao, Lo-Hsin; Tsai, Meng-Che; Liang, Ya-Lun; Strong, Carol; Lin, Chung-Ying

    2018-01-01

    Childhood adversity (CA) is associated with problem behaviors in adolescence, but the mediators, that is, those factors that help build resilience and prevent some children who experience CA from engaging in problem behaviors, await more exploration, including social integration. The aim of this study was to identify the association between CA and adolescent problem behaviors, and to further examine the mediating role of social integration distinctly as psychological and structural integration. Data used were from the Taiwan Education Panel Survey, a core panel of 4,261 students (age 13) surveyed in 2001 and followed for three more waves until age 18. For psychological integration, an average score was calculated to represent adolescents' feelings about their school. Structural integration was constructed using several items about adolescents' school and extracurricular activities. We used structural equation modeling with the diagonally weighted least squares method to examine the effect of CA on the primary outcome: adolescent problem behaviors via social integration. The hypothesized structural equation model specifying the path from CA to adolescent problem behavior had good fit. Respondents with one CA were indirectly linked to problem behaviors via psychological but not structural integration (e.g. the level of participation in school and non-school activities). On mediation analysis, psychological integration significantly mediated the paths from one CA to all six problem behaviors (all P integration; two or more CA were not associated with significant paths to problem behaviors. The contribution of social integration is crucial to an adolescent's development from CA to problem behaviors. To form supportive social relationships to achieve better health, we suggest that those adolescents who have been exposed to CA should be helped to join more teams and take part in more activities, thereby increasing their opportunities for social interaction, and improving

  16. Platform development supportedby gaming

    DEFF Research Database (Denmark)

    Mikkola, Juliana Hsuan; Hansen, Poul H. Kyvsgård

    2007-01-01

    The challenge of implementing industrial platforms in practice can be described as a configuration problem caused by high number of variables, which often have contradictory influences on the total performance of the firm. Consequently, the specific platform decisions become extremely complex......, possibly increasing the strategic risks for the firm. This paper reports preliminary findings on platform management process at LEGO, a Danish toy company.  Specifically, we report the process of applying games combined with simulations and workshops in the platform development. We also propose a framework...

  17. The Models of Market Economy on the Modern Technological Platforms

    Directory of Open Access Journals (Sweden)

    Sokolovska Zoia M.

    2017-11-01

    Full Text Available The article is aimed at analyzing the status of software provision of simulation modeling of economic systems and disclosing the possibilities of application of the integrated software-technological platforms in the building of market models. Problems in the field of applied introduction of the method of simulation modeling have been defined; the status of the software-technological provision of the simulation modeling of economic systems has been analyzed. It has been suggested to use the integrated system of multi-approach simulation modeling AnyLogic as one of the most powerful modern software platforms. The variant of the model of competitive multi-product market adapted to the specifics of pharmaceutical industry enterprises has been considered. The work of the model can be illustrated by results of the situational simulation experiments on the example of the pharmaceutical company «Farmak». The possibilities of parametric adjustment of imitation experiments together with the spectrum of their application in practical activity of pharmaceutical enterprises have been demonstrated.

  18. Integrated Concentration in Science (iCons): Undergraduate Education Through Interdisciplinary, Team-Based, Real-World Problem Solving

    Science.gov (United States)

    Tuominen, Mark

    2013-03-01

    Attitude, Skills, Knowledge (ASK) - In this order, these are fundamental characteristics of scientific innovators. Through first-hand practice in using science to unpack and solve complex real-world problems, students can become self-motivated scientific leaders. This presentation describes the pedagogy of a recently developed interdisciplinary undergraduate science education program at the University of Massachusetts Amherst focused on addressing global challenges with scientific solutions. Integrated Concentration in Science (iCons) is an overarching concentration program that supplements the curricula provided within each student's chosen major. iCons is a platform for students to perform student-led research in interdisciplinary collaborative teams. With a schedule of one course per year over four years, the cohort of students move through case studies, analysis of real-world problems, development of potential solutions, integrative communication, laboratory practice, and capstone research projects. In this presentation, a track emphasizing renewable energy science is used to illustrate the iCons pedagogical methods. This includes discussion of a third-year laboratory course in renewable energy that is educationally scaffolded: beginning with a boot camp in laboratory techniques and culminating with student-designed research projects. Among other objectives, this course emphasizes the practice of using reflection and redesign, as a means of generating better solutions and embedding learning for the long term. This work is supported in part by NSF grant DUE-1140805.

  19. Credit Risk Analysis of Local Government Financing Platform – An empirical study based on KMV model

    Directory of Open Access Journals (Sweden)

    Zhou Tingting

    2015-01-01

    Full Text Available The local government financing platform is set up by local government through state-owned assets, real estate and equity capital. The functions of these companies are financing, construction, operation, the repaying debts. The local government financing platform can broaden the financing channels of local government in a great extent; alleviate the pressure of capital requirement. But at the same time, with the gradual expansion of the scale of debt, a series of problems has arisen: the amount of financing platform companies is huge, debt repayment depends too much on real estate price, the integration of government administration with enterprise, capital injection, and accounts of these companies are not well exposed. Once these problems outbreak, it may cause a series of financial crises, thereby threaten the entire banking industry even the healthy development of the national economy.

  20. Monolithic integration of a silica AWG and Ge photodiodes on Si photonic platform for one-chip WDM receiver.

    Science.gov (United States)

    Nishi, Hidetaka; Tsuchizawa, Tai; Kou, Rai; Shinojima, Hiroyuki; Yamada, Takashi; Kimura, Hideaki; Ishikawa, Yasuhiko; Wada, Kazumi; Yamada, Koji

    2012-04-09

    On the silicon (Si) photonic platform, we monolithically integrated a silica-based arrayed-waveguide grating (AWG) and germanium (Ge) photodiodes (PDs) using low-temperature fabrication technology. We confirmed demultiplexing by the AWG, optical-electrical signal conversion by Ge PDs, and high-speed signal detection at all channels. In addition, we mounted a multichannel transimpedance amplifier/limiting amplifier (TIA/LA) circuit on the fabricated AWG-PD device using flip-chip bonding technology. The results show the promising potential of our Si photonic platform as a photonics-electronics convergence.

  1. MetaABC--an integrated metagenomics platform for data adjustment, binning and clustering.

    Science.gov (United States)

    Su, Chien-Hao; Hsu, Ming-Tsung; Wang, Tse-Yi; Chiang, Sufeng; Cheng, Jen-Hao; Weng, Francis C; Kao, Cheng-Yan; Wang, Daryi; Tsai, Huai-Kuang

    2011-08-15

    MetaABC is a metagenomic platform that integrates several binning tools coupled with methods for removing artifacts, analyzing unassigned reads and controlling sampling biases. It allows users to arrive at a better interpretation via series of distinct combinations of analysis tools. After execution, MetaABC provides outputs in various visual formats such as tables, pie and bar charts as well as clustering result diagrams. MetaABC source code and documentation are available at http://bits2.iis.sinica.edu.tw/MetaABC/ CONTACT: dywang@gate.sinica.edu.tw; hktsai@iis.sinica.edu.tw Supplementary data are available at Bioinformatics online.

  2. An integrated sample pretreatment platform for quantitative N-glycoproteome analysis with combination of on-line glycopeptide enrichment, deglycosylation and dimethyl labeling

    Energy Technology Data Exchange (ETDEWEB)

    Weng, Yejing; Qu, Yanyan; Jiang, Hao; Wu, Qi [National Chromatographic Research and Analysis Center, Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023 (China); University of the Chinese Academy of Sciences, Beijing 100039 (China); Zhang, Lihua, E-mail: lihuazhang@dicp.ac.cn [National Chromatographic Research and Analysis Center, Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023 (China); Yuan, Huiming [National Chromatographic Research and Analysis Center, Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023 (China); Zhou, Yuan [National Chromatographic Research and Analysis Center, Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023 (China); University of the Chinese Academy of Sciences, Beijing 100039 (China); Zhang, Xiaodan; Zhang, Yukui [National Chromatographic Research and Analysis Center, Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023 (China)

    2014-06-23

    Highlights: • An integrated platform for quantitative N-glycoproteome analysis was established. • On-line enrichment, deglycosylation and labeling could be achieved within 160 min. • A N{sub 2}-assisted interface was applied to improve the compatibility of the platform. • The platform exhibited improved quantification accuracy, precision and throughput. - Abstract: Relative quantification of N-glycoproteomes shows great promise for the discovery of candidate biomarkers and therapeutic targets. The traditional protocol for quantitative analysis of glycoproteomes is usually off-line performed, and suffers from long sample preparation time, and the risk of sample loss or contamination due to manual manipulation. In this study, a novel integrated sample preparation platform for quantitative N-glycoproteome analysis was established, with combination of online N-glycopeptide capture by a HILIC column, sample buffer exchange by a N{sub 2}-assisted HILIC–RPLC interface, deglycosylation by a hydrophilic PNGase F immobilized enzymatic reactor (hIMER) and solid dimethyl labeling on a C18 precolumn. To evaluate the performance of such a platform, two equal aliquots of immunoglobulin G (IgG) digests were sequentially pretreated, followed by MALDI-TOF MS analysis. The signal intensity ratio of heavy/light (H/L) labeled deglycosylated peptides with the equal aliquots was 1.00 (RSD = 6.2%, n = 3), much better than those obtained by the offline protocol, with H/L ratio as 0.76 (RSD = 11.6%, n = 3). Additionally, the total on-line sample preparation time was greatly shortened to 160 min, much faster than that of offline approach (24 h). Furthermore, such an integrated pretreatment platform was successfully applied to analyze the two kinds of hepatocarcinoma ascites syngeneic cell lines with high (Hca-F) and low (Hca-P) lymph node metastasis rates. For H/L labeled Hca-P lysates with the equal aliquots, 99.6% of log 2 ratios (H/L) of quantified glycopeptides ranged from −1

  3. Automatic and integrated micro-enzyme assay (AIμEA) platform for highly sensitive thrombin analysis via an engineered fluorescence protein-functionalized monolithic capillary column.

    Science.gov (United States)

    Lin, Lihua; Liu, Shengquan; Nie, Zhou; Chen, Yingzhuang; Lei, Chunyang; Wang, Zhen; Yin, Chao; Hu, Huiping; Huang, Yan; Yao, Shouzhuo

    2015-04-21

    Nowadays, large-scale screening for enzyme discovery, engineering, and drug discovery processes require simple, fast, and sensitive enzyme activity assay platforms with high integration and potential for high-throughput detection. Herein, a novel automatic and integrated micro-enzyme assay (AIμEA) platform was proposed based on a unique microreaction system fabricated by a engineered green fluorescence protein (GFP)-functionalized monolithic capillary column, with thrombin as an example. The recombinant GFP probe was rationally engineered to possess a His-tag and a substrate sequence of thrombin, which enable it to be immobilized on the monolith via metal affinity binding, and to be released after thrombin digestion. Combined with capillary electrophoresis-laser-induced fluorescence (CE-LIF), all the procedures, including thrombin injection, online enzymatic digestion in the microreaction system, and label-free detection of the released GFP, were integrated in a single electrophoretic process. By taking advantage of the ultrahigh loading capacity of the AIμEA platform and the CE automatic programming setup, one microreaction column was sufficient for many times digestion without replacement. The novel microreaction system showed significantly enhanced catalytic efficiency, about 30 fold higher than that of the equivalent bulk reaction. Accordingly, the AIμEA platform was highly sensitive with a limit of detection down to 1 pM of thrombin. Moreover, the AIμEA platform was robust and reliable to detect thrombin in human serum samples and its inhibition by hirudin. Hence, this AIμEA platform exhibits great potential for high-throughput analysis in future biological application, disease diagnostics, and drug screening.

  4. A collaborative platform for consensus sessions in pathology over Internet.

    Science.gov (United States)

    Zapletal, Eric; Le Bozec, Christel; Degoulet, Patrice; Jaulent, Marie-Christine

    2003-01-01

    The design of valid databases in pathology faces the problem of diagnostic disagreement between pathologists. Organizing consensus sessions between experts to reduce the variability is a difficult task. The TRIDEM platform addresses the issue to organize consensus sessions in pathology over the Internet. In this paper, we present the basis to achieve such collaborative platform. On the one hand, the platform integrates the functionalities of the IDEM consensus module that alleviates the consensus task by presenting to pathologists preliminary computed consensus through ergonomic interfaces (automatic step). On the other hand, a set of lightweight interaction tools such as vocal annotations are implemented to ease the communication between experts as they discuss a case (interactive step). The architecture of the TRIDEM platform is based on a Java-Server-Page web server that communicate with the ObjectStore PSE/PRO database used for the object storage. The HTML pages generated by the web server run Java applets to perform the different steps (automatic and interactive) of the consensus. The current limitations of the platform is to only handle a synchronous process. Moreover, improvements like re-writing the consensus workflow with a protocol such as BPML are already forecast.

  5. National Community Solar Platform

    Energy Technology Data Exchange (ETDEWEB)

    Rupert, Bart [Clean Energy Collective, Louisville, CO (United States)

    2016-06-30

    This project was created to provide a National Community Solar Platform (NCSP) portal known as Community Solar Hub, that is available to any entity or individual who wants to develop community solar. This has been done by providing a comprehensive portal to make CEC’s solutions, and other proven community solar solutions, externally available for everyone to access – making the process easy through proven platforms to protect subscribers, developers and utilities. The successful completion of this project provides these tools via a web platform and integration APIs, a wide spectrum of community solar projects included in the platform, multiple groups of customers (utilities, EPCs, and advocates) using the platform to develop community solar, and open access to anyone interested in community solar. CEC’s Incubator project includes web-based informational resources, integrated systems for project information and billing systems, and engagement with customers and users by community solar experts. The combined effort externalizes much of Clean Energy Collective’s industry-leading expertise, allowing third parties to develop community solar without duplicating expensive start-up efforts. The availability of this platform creates community solar projects that are cheaper to build and cheaper to participate in, furthering the goals of DOE’s SunShot Initiative. Final SF 425 Final SF 428 Final DOE F 2050.11 Final Report Narrative

  6. Cost-effective improvements of a rotating platform by integration of a high-accuracy inclinometer and encoders for attitude evaluation

    International Nuclear Information System (INIS)

    Wen, Chenyang; He, Shengyang; Hu, Peida; Bu, Changgen

    2017-01-01

    Attitude heading reference systems (AHRSs) based on micro-electromechanical system (MEMS) inertial sensors are widely used because of their low cost, light weight, and low power. However, low-cost AHRSs suffer from large inertial sensor errors. Therefore, experimental performance evaluation of MEMS-based AHRSs after system implementation is necessary. High-accuracy turntables can be used to verify the performance of MEMS-based AHRSs indoors, but they are expensive and unsuitable for outdoor tests. This study developed a low-cost two-axis rotating platform for indoor and outdoor attitude determination. A high-accuracy inclinometer and encoders were integrated into the platform to improve the achievable attitude test accuracy. An attitude error compensation method was proposed to calibrate the initial attitude errors caused by the movements and misalignment angles of the platform. The proposed attitude error determination method was examined through rotating experiments, which showed that the standard deviations of the pitch and roll errors were 0.050° and 0.090°, respectively. The pitch and roll errors both decreased to 0.024° when the proposed attitude error determination method was used. This decrease validates the effectiveness of the compensation method. Experimental results demonstrated that the integration of the inclinometer and encoders improved the performance of the low-cost, two-axis, rotating platform in terms of attitude accuracy. (paper)

  7. Time-varying spatial data integration and visualization: 4 Dimensions Environmental Observations Platform (4-DEOS)

    Science.gov (United States)

    Paciello, Rossana; Coviello, Irina; Filizzola, Carolina; Genzano, Nicola; Lisi, Mariano; Mazzeo, Giuseppe; Pergola, Nicola; Sileo, Giancanio; Tramutoli, Valerio

    2014-05-01

    In environmental studies the integration of heterogeneous and time-varying data, is a very common requirement for investigating and possibly visualize correlations among physical parameters underlying the dynamics of complex phenomena. Datasets used in such kind of applications has often different spatial and temporal resolutions. In some case superimposition of asynchronous layers is required. Traditionally the platforms used to perform spatio-temporal visual data analyses allow to overlay spatial data, managing the time using 'snapshot' data model, each stack of layers being labeled with different time. But this kind of architecture does not incorporate the temporal indexing neither the third spatial dimension which is usually given as an independent additional layer. Conversely, the full representation of a generic environmental parameter P(x,y,z,t) in the 4D space-time domain could allow to handle asynchronous datasets as well as less traditional data-products (e.g. vertical sections, punctual time-series, etc.) . In this paper we present the 4 Dimensions Environmental Observation Platform (4-DEOS), a system based on a web services architecture Client-Broker-Server. This platform is a new open source solution for both a timely access and an easy integration and visualization of heterogeneous (maps, vertical profiles or sections, punctual time series, etc.) asynchronous, geospatial products. The innovative aspect of the 4-DEOS system is that users can analyze data/products individually moving through time, having also the possibility to stop the display of some data/products and focus on other parameters for better studying their temporal evolution. This platform gives the opportunity to choose between two distinct display modes for time interval or for single instant. Users can choose to visualize data/products in two ways: i) showing each parameter in a dedicated window or ii) visualize all parameters overlapped in a single window. A sliding time bar, allows

  8. A technical review of flexible endoscopic multitasking platforms.

    Science.gov (United States)

    Yeung, Baldwin Po Man; Gourlay, Terence

    2012-01-01

    Further development of advanced therapeutic endoscopic techniques and natural orifice translumenal endoscopic surgery (NOTES) requires a powerful flexible endoscopic multitasking platform. Medline search was performed to identify literature relating to flexible endoscopic multitasking platform from year 2004-2011 using keywords: Flexible endoscopic multitasking platform, NOTES, Instrumentation, Endoscopic robotic surgery, and specific names of various endoscopic multitasking platforms. Key articles from articles references were reviewed. Flexible multitasking platforms can be classified as either mechanical or robotic. Purely mechanical systems include the dual channel endoscope (DCE) (Olympus), R-Scope (Olympus), the EndoSamurai (Olympus), the ANUBIScope (Karl-Storz), Incisionless Operating Platform (IOP) (USGI), and DDES system (Boston Scientific). Robotic systems include the MASTER system (Nanyang University, Singapore) and the Viacath (Hansen Medical). The DCE, the R-Scope, the EndoSamurai and the ANUBIScope have integrated visual function and instrument manipulation function. The IOP and DDES systems rely on the conventional flexible endoscope for visualization, and instrument manipulation is integrated through the use of a flexible, often lockable, multichannel access device. The advantage of the access device concept is that it allows optics and instrument dissociation. Due to the anatomical constrains of the pharynx, systems are designed to have a diameter of less than 20 mm. All systems are controlled by traction cable system actuated either by hand or by robotic machinery. In a flexible system, this method of actuation inevitably leads to significant hysteresis. This problem will be accentuated with a long endoscope such as that required in performing colonic procedures. Systems often require multiple operators. To date, the DCE, the R-Scope, the IOP, and the Viacath system have data published relating to their application in human. Alternative forms of

  9. Compensating Unknown Time-Varying Delay in Opto-Electronic Platform Tracking Servo System

    Directory of Open Access Journals (Sweden)

    Ruihong Xie

    2017-05-01

    Full Text Available This paper investigates the problem of compensating miss-distance delay in opto-electronic platform tracking servo system. According to the characteristic of LOS (light-of-sight motion, we setup the Markovian process model and compensate this unknown time-varying delay by feed-forward forecasting controller based on robust H∞ control. Finally, simulation based on double closed-loop PI (Proportion Integration control system indicates that the proposed method is effective for compensating unknown time-varying delay. Tracking experiments on the opto-electronic platform indicate that RMS (root-mean-square error is 1.253 mrad when tracking 10° 0.2 Hz signal.

  10. A new integrability theory for certain nonlinear physical problems

    International Nuclear Information System (INIS)

    Berger, M.S.

    1993-01-01

    A new mathematically sound integrability theory for certain nonlinear problems defined by ordinary or partial differential equations is defined. The new theory works in an arbitrary finite number of space dimensions. Moreover, if a system is integrable in the new sense described here, it has a remarkable stability property that distinguishes if from any previously known integrability ideas. The new theory proceeds by establishing a ''global normal form'' for the problem at hand. This normal form holds subject to canonical coordinate transformations, extending such classical ideas by using new nonlinear methods of infinite dimensional functional analysis. The global normal form in question is related to the mathematical theory of singularities of mappings of H. Whitney and R. Thom extended globally and form finite to infinite dimensions. Thus bifurcation phenomena are naturally included in the new integrability theory. Typical examples include the classically nonintegrable Riccati equation, certain non-Euclidean mean field theories, certain parabolic reaction diffusion equations and the hyperbolic nonlinear telegrapher's equation. (Author)

  11. Radiographic inspection on offshore platforms

    International Nuclear Information System (INIS)

    Soares, Sergio Damasceno; Sperandio, Augusto Gasparoni

    1994-01-01

    One of the great challenges for non-destructive inspection is on offshore platforms, where safety is a critical issue. Inspection by gammagraphy is practically forbidden on the platform deck due to problems to personnel safety and radiological protection. Ir-192 sources are used and the risk of an accident with loss of radioisotope must be considered. It is unfeasible to use gammagraphy, because in case of an accident the rapid evacuation from the platform would be impossible. This problem does not occur when X-ray equipment is used as the radiation source. The limited practicality and portability of the X-ray equipment have prevented its use as a replacement for the gammagraphy. This paper presents the preliminary tests to see the viable use of radiographic tests with constant potential on offshore platforms. (author). 2 refs., 1 fig., 2 tabs, 3 photos

  12. Non-integrability of the generalized spring-pendulum problem

    International Nuclear Information System (INIS)

    Maciejewski, Andrzej J; Przybylska, Maria; Weil, Jacques-Arthur

    2004-01-01

    We investigate a generalization of the three-dimensional spring-pendulum system. The problem depends on two real parameters (k, a), where k is the Young modulus of the spring and a describes the nonlinearity of elastic forces. We show that this system is not integrable when k ≠ -a. We carefully investigated the case k = -a when the necessary condition for integrability given by the Morales-Ruiz-Ramis theory is satisfied. We discuss an application of the higher order variational equations for proving the non-integrability in this case

  13. Beyond Open Source Software: Solving Common Library Problems Using the Open Source Hardware Arduino Platform

    Directory of Open Access Journals (Sweden)

    Jonathan Younker

    2013-06-01

    Full Text Available Using open source hardware platforms like the Arduino, libraries have the ability to quickly and inexpensively prototype custom hardware solutions to common library problems. The authors present the Arduino environment, what it is, what it does, and how it was used at the James A. Gibson Library at Brock University to create a production portable barcode-scanning utility for in-house use statistics collection as well as a prototype for a service desk statistics tabulation program’s hardware interface.

  14. Integrated numerical platforms for environmental dose assessments of large tritium inventory facilities

    International Nuclear Information System (INIS)

    Castro, P.; Ardao, J.; Velarde, M.; Sedano, L.; Xiberta, J.

    2013-01-01

    Related with a prospected new scenario of large inventory tritium facilities [KATRIN at TLK, CANDUs, ITER, EAST, other coming] the prescribed dosimetric limits by ICRP-60 for tritium committed-doses are under discussion requiring, in parallel, to surmount the highly conservative assessments by increasing the refinement of dosimetric-assessments in many aspects. Precise Lagrangian-computations of dosimetric cloud-evolution after standardized (normal/incidental/SBO) tritium cloud emissions are today numerically open to the perfect match of real-time meteorological-data, and patterns data at diverse scales for prompt/early and chronic tritium dose assessments. The trends towards integrated-numerical-platforms for environmental-dose assessments of large tritium inventory facilities under development.

  15. Towards Digital Integration: Platform Thinking in the Fashion Business

    DEFF Research Database (Denmark)

    Schou, Finn

    2005-01-01

    ¬quately to changing demands in their business activities. However many companies find it dif¬ficult to achieve the full poten¬tial of these technologies as practical advices that can help companies and the management in their decision-making, selecting and implementing new technology are rare (Boer and Krabbendam......, 1998). The intention of this paper is, through illustrative case studies from France and Denmark within the highly competitive business of optical frame design (fashion) to present a model for strategy as well as a practical model for improvement of time to market of styling objects by use of digital...... platforms. Aspects are: 1) selection of platform from a strategic point of view, 2) selection of 2D and 3D CAD from a practical point of view and 3) creation and implementation of digital platforms. Finally, briefly aspects of teaching of platform theory at the department of Architecture & Industrial design...

  16. Model Integrated Problem Solving Based Learning pada Perkuliahan Dasar-dasar Kimia Analitik

    OpenAIRE

    Indarini Dwi Pursitasari; Anna Permanasari

    2013-01-01

    Abstract: Integrated Problem Solving Based Learning Model on Foundation of Analytical Chemistry. This study was conducted to know the effects of Integrated Problem Solving Based Learning (IPSBL) model on problem solving skills and cognitive ability of pre-service teachers. The subjects of the study were 41 pre- service teachers, 21 in the experimental group and 20 in the control group. The data were collected through a test on problem solving skills, a test on cognitive ability, and a questio...

  17. Model Integrated Problem Solving Based Learning Pada Perkuliahan Dasar-dasar Kimia Analitik

    OpenAIRE

    Pursitasari, Indarini Dwi; Permanasari, Anna

    2012-01-01

    : Integrated Problem Solving Based Learning Model on Foundation of Analytical Chemistry. This study was conducted to know the effects of Integrated Problem Solving Based Learning (IPSBL) model on problem solving skills and cognitive ability of pre-service teachers. The subjects of the study were 41 pre- service teachers, 21 in the experimental group and 20 in the control group. The data were collected through a test on problem solving skills, a test on cognitive ability, and a questionnaire o...

  18. Catalyst-Free Vapor-Phase Method for Direct Integration of Gas Sensing Nanostructures with Polymeric Transducing Platforms

    Directory of Open Access Journals (Sweden)

    Stella Vallejos

    2014-01-01

    Full Text Available Tungsten oxide nanoneedles (NNs are grown and integrated directly with polymeric transducing platforms for gas sensors via aerosol-assisted chemical vapor deposition (AACVD method. Material analysis shows the feasibility to grow highly crystalline nanomaterials in the form of NNs with aspect ratios between 80 and 200 and with high concentration of oxygen vacancies at the surface, whereas gas testing demonstrates moderate sensing responses to hydrogen at concentrations between 10 ppm and 50 ppm, which are comparable with results for tungsten oxide NNs grown on silicon transducing platforms. This method is demonstrated to be an attractive route to fabricate next generation of gas sensors devices, provided with flexibility and functionality, with great potential in a cost effective production for large-scale applications.

  19. Optimal solution of full fuzzy transportation problems using total integral ranking

    Science.gov (United States)

    Sam’an, M.; Farikhin; Hariyanto, S.; Surarso, B.

    2018-03-01

    Full fuzzy transportation problem (FFTP) is a transportation problem where transport costs, demand, supply and decision variables are expressed in form of fuzzy numbers. To solve fuzzy transportation problem, fuzzy number parameter must be converted to a crisp number called defuzzyfication method. In this new total integral ranking method with fuzzy numbers from conversion of trapezoidal fuzzy numbers to hexagonal fuzzy numbers obtained result of consistency defuzzyfication on symmetrical fuzzy hexagonal and non symmetrical type 2 numbers with fuzzy triangular numbers. To calculate of optimum solution FTP used fuzzy transportation algorithm with least cost method. From this optimum solution, it is found that use of fuzzy number form total integral ranking with index of optimism gives different optimum value. In addition, total integral ranking value using hexagonal fuzzy numbers has an optimal value better than the total integral ranking value using trapezoidal fuzzy numbers.

  20. Applied architecture patterns on the Microsoft platform

    CERN Document Server

    Dovgal, Andre; Noriskin, Gregor

    2014-01-01

    Presented in a scenario-driven tutorial way, we lead you through fictitious example problems and present you with the best solutions. This book is intended for architects, developers, and managers who need to improve their knowledge of the Microsoft application platform. This book will appeal to anyone, especially consultants, who want to get up to speed on selecting the most appropriate platform for a particular problem. A good understanding of the general Windows platform and development technologies would be helpful.

  1. TECHNOLOGICAL PLATFORMS IN RUSSIAN NANOINDUSTRY: PROPLEMS AND PROSPECTS OF DEVELOPMENT

    Directory of Open Access Journals (Sweden)

    Oleg Inshakov

    2017-12-01

    Full Text Available The article discloses the economic content of technological platform (TP as a system of transactional relations of its participants, which provides the most beneficial interactions on the basis of a common goal and unity of interests. TP can generate clusters corresponding to its profile, based on common basic technologies. Reduction of the meaning of TPs and clusters to the notion of an “instrument” of economic policy hinders the disclosure of their economic content, which becomes a relevant theoretical problem and a barrier to the effective use of TPs in nanoindustry. Creation of nanotechnology platforms didn’t become an independent direction, however, RUSNANO became the coordinator and participant of 6 TPs. With RUSNANO participation 6 innovative clusters have been created, and 5 more within 10 years. Further development of Russian nanoindustry cannot be related only to clustering at macrolevel, but involves horizontal integration of nanotechnologies into various country’s specific TPs and vertical integration into TPs and clusters at the EAEU (Eurasian Economic Union scale. Nanotechnology projects financing in Eurasian TPs is attributed to the most complicated problems of their functioning, taking into account the insufficient rates of integration in the EAEU. The article argues the feasibility of financing Eurasian nanoindustry TPs on the basis of public-private partnership mechanism and the need to shift from its budgetary part to extra-budgetary as the “life cycle” of the TP develops, and its institutional and organizational maturity is increased. This will allow Russian and Eurasian TPs to realize their significant potential of resourcing the domestic nanoindustry development.

  2. 油田信息集成平台的设计与实现%Design and implementation of oilfield information integration platform

    Institute of Scientific and Technical Information of China (English)

    刘厚铭

    2011-01-01

    The paper proposes a kind of information integration solution for the information communicating;and aharing problems of multiple independent systems of Oil intemal companies,achieves the integration of diverse data streams and network information, human enterprise portal management and Services,describes the overall framework and analyses some key technologies of the platform from the unified authentication,user management and personalized interface customization.%针对油田内部多种独立系统信息的交流与共享问题,提出了一种信息集成解决方案,以实现多样化数据流和网络信息整合及企业门户人性化管理和服务,并从统一身份认证、统一用户管理和个性化界面定制等方面介绍了该平台的总体框架,分析了实现该平台的一些关键技术.

  3. Hierarchical DSE for multi-ASIP platforms

    DEFF Research Database (Denmark)

    Micconi, Laura; Corvino, Rosilde; Gangadharan, Deepak

    2013-01-01

    This work proposes a hierarchical Design Space Exploration (DSE) for the design of multi-processor platforms targeted to specific applications with strict timing and area constraints. In particular, it considers platforms integrating multiple Application Specific Instruction Set Processors (ASIPs...

  4. A point implicit time integration technique for slow transient flow problems

    Energy Technology Data Exchange (ETDEWEB)

    Kadioglu, Samet Y., E-mail: kadioglu@yildiz.edu.tr [Department of Mathematical Engineering, Yildiz Technical University, 34210 Davutpasa-Esenler, Istanbul (Turkey); Berry, Ray A., E-mail: ray.berry@inl.gov [Idaho National Laboratory, P.O. Box 1625, MS 3840, Idaho Falls, ID 83415 (United States); Martineau, Richard C. [Idaho National Laboratory, P.O. Box 1625, MS 3840, Idaho Falls, ID 83415 (United States)

    2015-05-15

    Highlights: • This new method does not require implicit iteration; instead it time advances the solutions in a similar spirit to explicit methods. • It is unconditionally stable, as a fully implicit method would be. • It exhibits the simplicity of implementation of an explicit method. • It is specifically designed for slow transient flow problems of long duration such as can occur inside nuclear reactor coolant systems. • Our findings indicate the new method can integrate slow transient problems very efficiently; and its implementation is very robust. - Abstract: We introduce a point implicit time integration technique for slow transient flow problems. The method treats the solution variables of interest (that can be located at cell centers, cell edges, or cell nodes) implicitly and the rest of the information related to same or other variables are handled explicitly. The method does not require implicit iteration; instead it time advances the solutions in a similar spirit to explicit methods, except it involves a few additional function(s) evaluation steps. Moreover, the method is unconditionally stable, as a fully implicit method would be. This new approach exhibits the simplicity of implementation of explicit methods and the stability of implicit methods. It is specifically designed for slow transient flow problems of long duration wherein one would like to perform time integrations with very large time steps. Because the method can be time inaccurate for fast transient problems, particularly with larger time steps, an appropriate solution strategy for a problem that evolves from a fast to a slow transient would be to integrate the fast transient with an explicit or semi-implicit technique and then switch to this point implicit method as soon as the time variation slows sufficiently. We have solved several test problems that result from scalar or systems of flow equations. Our findings indicate the new method can integrate slow transient problems very

  5. A point implicit time integration technique for slow transient flow problems

    International Nuclear Information System (INIS)

    Kadioglu, Samet Y.; Berry, Ray A.; Martineau, Richard C.

    2015-01-01

    Highlights: • This new method does not require implicit iteration; instead it time advances the solutions in a similar spirit to explicit methods. • It is unconditionally stable, as a fully implicit method would be. • It exhibits the simplicity of implementation of an explicit method. • It is specifically designed for slow transient flow problems of long duration such as can occur inside nuclear reactor coolant systems. • Our findings indicate the new method can integrate slow transient problems very efficiently; and its implementation is very robust. - Abstract: We introduce a point implicit time integration technique for slow transient flow problems. The method treats the solution variables of interest (that can be located at cell centers, cell edges, or cell nodes) implicitly and the rest of the information related to same or other variables are handled explicitly. The method does not require implicit iteration; instead it time advances the solutions in a similar spirit to explicit methods, except it involves a few additional function(s) evaluation steps. Moreover, the method is unconditionally stable, as a fully implicit method would be. This new approach exhibits the simplicity of implementation of explicit methods and the stability of implicit methods. It is specifically designed for slow transient flow problems of long duration wherein one would like to perform time integrations with very large time steps. Because the method can be time inaccurate for fast transient problems, particularly with larger time steps, an appropriate solution strategy for a problem that evolves from a fast to a slow transient would be to integrate the fast transient with an explicit or semi-implicit technique and then switch to this point implicit method as soon as the time variation slows sufficiently. We have solved several test problems that result from scalar or systems of flow equations. Our findings indicate the new method can integrate slow transient problems very

  6. Integrated network design and scheduling problems :

    Energy Technology Data Exchange (ETDEWEB)

    Nurre, Sarah G.; Carlson, Jeffrey J.

    2014-01-01

    We consider the class of integrated network design and scheduling problems. These problems focus on selecting and scheduling operations that will change the characteristics of a network, while being speci cally concerned with the performance of the network over time. Motivating applications of INDS problems include infrastructure restoration after extreme events and building humanitarian distribution supply chains. While similar models have been proposed, no one has performed an extensive review of INDS problems from their complexity, network and scheduling characteristics, information, and solution methods. We examine INDS problems under a parallel identical machine scheduling environment where the performance of the network is evaluated by solving classic network optimization problems. We classify that all considered INDS problems as NP-Hard and propose a novel heuristic dispatching rule algorithm that selects and schedules sets of arcs based on their interactions in the network. We present computational analysis based on realistic data sets representing the infrastructures of coastal New Hanover County, North Carolina, lower Manhattan, New York, and a realistic arti cial community CLARC County. These tests demonstrate the importance of a dispatching rule to arrive at near-optimal solutions during real-time decision making activities. We extend INDS problems to incorporate release dates which represent the earliest an operation can be performed and exible release dates through the introduction of specialized machine(s) that can perform work to move the release date earlier in time. An online optimization setting is explored where the release date of a component is not known.

  7. Integration of the program TNXYZ in the platform SALOME; Integracion del programa TNXYZ en la plataforma SALOME

    Energy Technology Data Exchange (ETDEWEB)

    Chaparro V, F. J.; Silva A, L.; Del Valle G, E. [IPN, Escuela Superior de Fisica y Matematicas, Av. Instituto Politecnico Nacional s/n, U.P. Adolfo Lopez Mateos, Edificio 9, Col. San Pedro Zacatenco, 07738 Mexico D. F. (Mexico); Gomez T, A. M.; Vargas E, S., E-mail: javier.paquito@hotmail.com [ININ, Carretera Mexico-Toluca s/n, 52750 Ocoyoacac, Estado de Mexico (Mexico)

    2013-10-15

    This work presents the procedure realized to integrate the code TNXYZ like a processing tool to the graphic simulation platform SALOME. The code TNXYZ solves the neutron transport equation in stationary state, for several energy groups, quantizing the angular variable by the discrete ordinates method and the space variable by nodal methods. The platform SALOME is a graphic surrounding designed for the construction, edition and simulation of mechanical models focused to the industry and contrary to other software, it allows to integrate external source codes to the surrounding, to form a complete scheme of execution, supervision, pre and post information processing. The code TNXYZ was programmed in the 90s in a Fortran compiler, but to be used at the present time the code should be actualized to the current compiler characteristics; also, in the original scheme was carried out a modularization process, that is to say, the main program was divided in sections where the code carries out important operations, with the intention of flexibility the data extraction process along its processing sequence and that can be useful in a later development of coupling. Finally, to verify the integration a fuel assembly BWR was modeled, as well as a control cell. The cross sections were obtained with the Monte Carlo Serpent code. Some results obtained with Serpent were used to verify and to begin with the validation of the code, being obtained an acceptable comparison in the infinite multiplication factor. The validation process should extend and one has planned to present in a future work. This work is part of the development of the research group formed between the Escuela Superior de Fisica y Matematicas del Instituto Politecnico Nacional (IPN) and the Instituto Nacional de Investigaciones Nucleares (ININ) in which a simulation Mexican platform of nuclear reactors is developed. (Author)

  8. A wireless sensor tag platform for container security and integrity

    Science.gov (United States)

    Amaya, Ivan A.; Cree, Johnathan V.; Mauss, Fredrick J.

    2011-04-01

    Cargo containers onboard ships are widely used in the global supply chain. The need for container security is evidenced by the Container Security Initiative launched by the U.S. Bureau of Customs and Border Protection (CBP). One method of monitoring cargo containers is using low power wireless sensor tags. The wireless sensor tags are used to set up a network that is comprised of tags internal to the container and a central device. The sensor network reports alarms and other anomalies to a central device, which then relays the message to an outside network upon arrival at the destination port. This allows the port authorities to have knowledge of potential security or integrity issues before physically examining the container. Challenges of using wireless sensor tag networks for container security include battery life, size, environmental conditions, information security, and cost among others. PNNL developed an active wireless sensor tag platform capable of reporting data wirelessly to a central node as well as logging data to nonvolatile memory. The tags, operate at 2.4 GHz over an IEEE 802.15.4 protocol, and were designed to be distributed throughout the inside of a shipping container in the upper support frame. The tags are mounted in a housing that allows for simple and efficient installation or removal prior to, during, or after shipment. The distributed tags monitor the entire container volume. The sensor tag platform utilizes low power electronics and provides an extensible sensor interface for incorporating a wide range of sensors including chemical, biological, and environmental sensors.

  9. Construction of a test platform for Test Blanket Module (TBM) systems integration and maintenance in ITER Port Cell #16

    Energy Technology Data Exchange (ETDEWEB)

    Vála, Ladislav, E-mail: ladislav.vala@cvrez.cz [Centrum výzkumu Řež, Hlavní 130, 250 68 Husinec-Řež (Czech Republic); Reungoat, Mathieu, E-mail: mathieu.reungoat@cvrez.cz [Centrum výzkumu Řež, Hlavní 130, 250 68 Husinec-Řež (Czech Republic); Vician, Martin [Centrum výzkumu Řež, Hlavní 130, 250 68 Husinec-Řež (Czech Republic); Poitevin, Yves; Ricapito, Italo; Zmitko, Milan; Panayotov, Dobromir [Fusion for Energy, Josep Pla 2, Torres Diagonal Litoral B3, 08019 Barcelona (Spain)

    2015-10-15

    Highlights: • A non-nuclear, full size facility – TBM platform – is under construction in CVR. • It is designed for tests, optimization and validation of TBS maintenance operations. • It will allow testing and validation of specific maintenance tools and RH equipment. • It reproduces ITER Port Cell #16, as well as the TBS interfaces and main equipment. • The TBM platform will be available for full operation in the first half of 2016. - Abstract: This paper describes a project of a non-nuclear, 1:1 scale testing platform dedicated to tests, optimization and validation of integration and maintenance operations for the European TBM systems in the ITER Port Cell #16. This TBM platform is currently under construction in Centrum výzkumu Řež, Czech Republic. The facility is realized within the scope of the SUSEN project and its full operation is foreseen in the first half of 2016.

  10. Model Integrated Problem Solving Based Learning pada Perkuliahan Dasar-dasar Kimia Analitik

    Directory of Open Access Journals (Sweden)

    Indarini Dwi Pursitasari

    2013-07-01

    Full Text Available Abstract: Integrated Problem Solving Based Learning Model on Foundation of Analytical Chemistry. This study was conducted to know the effects of Integrated Problem Solving Based Learning (IPSBL model on problem solving skills and cognitive ability of pre-service teachers. The subjects of the study were 41 pre- service teachers, 21 in the experimental group and 20 in the control group. The data were collected through a test on problem solving skills, a test on cognitive ability, and a questionnaire on the students’opinions on the use of IPSBL model. The quantitative data were analyzed using t-test and one-way ANOVA, and the qualitative data were analyzed by counting the percentage. The results of the study show that the implementation of IPSBL model increased the problem solving skills and cognitive ability of the pre-service teachers . The model was also responded positively by the research subjects. Abstrak: Model Integrated Problem Solving Based learning pada Perkuliahan Dasar-dasar Kimia Analitik. Penelitian ini bertujuan menentukan pengaruh model Integrated Problem Solving Based Learning(IPSBL terhadap peningkatan kemampuan problem solving dan kemampuan kognitif mahasiswa calon guru. Subjek penelitian terdiri dari 21 mahasiswa kelas eksperimen dan 20 mahasiswa kelas kontrol. Data dikumpulkan menggunakan tes kemampuan problem solving, tes kemampuan kognitif, dan angket untuk menjaring pendapat mahasiswa terhadap penggunaan model IPSBL . Data kuantitatif dianalisis denga n uji- t dan Anava dengan bantuan program SPSS 16.0. Data kualitatif dihitung persentasenya. Hasil penelitian menunjukkan bahwa model IPSBL dapat meningkatkan kemampuan problem solving dan kemampuan kognitif serta mendapat tanggapan yang positif dari mahasiswa.

  11. Plasmonic nanofocusing of light in an integrated silicon photonics platform.

    Science.gov (United States)

    Desiatov, Boris; Goykhman, Ilya; Levy, Uriel

    2011-07-04

    The capability to focus electromagnetic energy at the nanoscale plays an important role in nanoscinece and nanotechnology. It allows enhancing light matter interactions at the nanoscale with applications related to nonlinear optics, light emission and light detection. It may also be used for enhancing resolution in microscopy, lithography and optical storage systems. Hereby we propose and experimentally demonstrate the nanoscale focusing of surface plasmons by constructing an integrated plasmonic/photonic on chip nanofocusing device in silicon platform. The device was tested directly by measuring the optical intensity along it using a near-field microscope. We found an order of magnitude enhancement of the intensity at the tip's apex. The spot size is estimated to be 50 nm. The demonstrated device may be used as a building block for "lab on a chip" systems and for enhancing light matter interactions at the apex of the tip.

  12. A Comprehensive Review of Boundary Integral Formulations of Acoustic Scattering Problems

    Directory of Open Access Journals (Sweden)

    S.I. Zaman

    2000-12-01

    Full Text Available This is a review presenting an overview of the developments in boundary integral formulations of the acoustic scattering problems. Generally, the problem is formulated in one of two ways viz. Green’s representation formula, and the Layer-theoretic formulation utilizing either a simple-layer or a double-layer potential. The review presents and expounds the major contributions in this area over the last four decades. The need for a robust and improved formulation of the exterior scattering problem (Neumann or Dirichlet arose due to the fact that the classical formulation failed to yield a unique solution at (acoustic wave-numbers which correspond to eigenvalues (eigenfrequencies of the corresponding interior scattering problem. Moreover, this correlation becomes more pronounced as the wave-numbers become larger i.e. as the (acoustic frequency increases. The robust integral formulations which are discussed here yield Fredholms integral equations of the second kind which are more amenable to computation than the first kind. However, the integral equation involves a hypersingular kernel which creates ill-conditioning in the final matrix representation. This is circumvented by a regularisation technique. An extensive useful list of references is also presented here for researchers in this area.

  13. An intermittent rocking platform for integrated expansion and differentiation of human pluripotent stem cells to cardiomyocytes in suspended microcarrier cultures

    Directory of Open Access Journals (Sweden)

    Sherwin Ting

    2014-09-01

    In conclusion, we have developed a simple robust and scalable platform that integrates both hESC expansion and CM differentiation in one unit process which is capable of meeting the need for large amounts of CMs.

  14. IMGMD: A platform for the integration and standardisation of In silico Microbial Genome-scale Metabolic Models.

    Science.gov (United States)

    Ye, Chao; Xu, Nan; Dong, Chuan; Ye, Yuannong; Zou, Xuan; Chen, Xiulai; Guo, Fengbiao; Liu, Liming

    2017-04-07

    Genome-scale metabolic models (GSMMs) constitute a platform that combines genome sequences and detailed biochemical information to quantify microbial physiology at the system level. To improve the unity, integrity, correctness, and format of data in published GSMMs, a consensus IMGMD database was built in the LAMP (Linux + Apache + MySQL + PHP) system by integrating and standardizing 328 GSMMs constructed for 139 microorganisms. The IMGMD database can help microbial researchers download manually curated GSMMs, rapidly reconstruct standard GSMMs, design pathways, and identify metabolic targets for strategies on strain improvement. Moreover, the IMGMD database facilitates the integration of wet-lab and in silico data to gain an additional insight into microbial physiology. The IMGMD database is freely available, without any registration requirements, at http://imgmd.jiangnan.edu.cn/database.

  15. An exploration of knowledge integration problems in interdisciplinary research teams

    NARCIS (Netherlands)

    Bayerl, P.S.; Steinheider, B.

    2009-01-01

    The integration of function-specific expertise into a shared knowledge base is a crucial, but complex process for success in interdisciplinary teams. This paper presents an empirically derived typology of knowledge integration problems and links their occurrence to degree of heterogeneity and

  16. SAW-Based Phononic Crystal Microfluidic Sensor-Microscale Realization of Velocimetry Approaches for Integrated Analytical Platform Applications.

    Science.gov (United States)

    Oseev, Aleksandr; Lucklum, Ralf; Zubtsov, Mikhail; Schmidt, Marc-Peter; Mukhin, Nikolay V; Hirsch, Soeren

    2017-09-23

    The current work demonstrates a novel surface acoustic wave (SAW) based phononic crystal sensor approach that allows the integration of a velocimetry-based sensor concept into single chip integrated solutions, such as Lab-on-a-Chip devices. The introduced sensor platform merges advantages of ultrasonic velocimetry analytic systems and a microacoustic sensor approach. It is based on the analysis of structural resonances in a periodic composite arrangement of microfluidic channels confined within a liquid analyte. Completed theoretical and experimental investigations show the ability to utilize periodic structure localized modes for the detection of volumetric properties of liquids and prove the efficacy of the proposed sensor concept.

  17. High Speed Solution of Spacecraft Trajectory Problems Using Taylor Series Integration

    Science.gov (United States)

    Scott, James R.; Martini, Michael C.

    2008-01-01

    Taylor series integration is implemented in a spacecraft trajectory analysis code-the Spacecraft N-body Analysis Program (SNAP) - and compared with the code s existing eighth-order Runge-Kutta Fehlberg time integration scheme. Nine trajectory problems, including near Earth, lunar, Mars and Europa missions, are analyzed. Head-to-head comparison at five different error tolerances shows that, on average, Taylor series is faster than Runge-Kutta Fehlberg by a factor of 15.8. Results further show that Taylor series has superior convergence properties. Taylor series integration proves that it can provide rapid, highly accurate solutions to spacecraft trajectory problems.

  18. Recent advances in computational-analytical integral transforms for convection-diffusion problems

    Science.gov (United States)

    Cotta, R. M.; Naveira-Cotta, C. P.; Knupp, D. C.; Zotin, J. L. Z.; Pontes, P. C.; Almeida, A. P.

    2017-10-01

    An unifying overview of the Generalized Integral Transform Technique (GITT) as a computational-analytical approach for solving convection-diffusion problems is presented. This work is aimed at bringing together some of the most recent developments on both accuracy and convergence improvements on this well-established hybrid numerical-analytical methodology for partial differential equations. Special emphasis is given to novel algorithm implementations, all directly connected to enhancing the eigenfunction expansion basis, such as a single domain reformulation strategy for handling complex geometries, an integral balance scheme in dealing with multiscale problems, the adoption of convective eigenvalue problems in formulations with significant convection effects, and the direct integral transformation of nonlinear convection-diffusion problems based on nonlinear eigenvalue problems. Then, selected examples are presented that illustrate the improvement achieved in each class of extension, in terms of convergence acceleration and accuracy gain, which are related to conjugated heat transfer in complex or multiscale microchannel-substrate geometries, multidimensional Burgers equation model, and diffusive metal extraction through polymeric hollow fiber membranes. Numerical results are reported for each application and, where appropriate, critically compared against the traditional GITT scheme without convergence enhancement schemes and commercial or dedicated purely numerical approaches.

  19. An Experimental Analysis on Dispatching Rules for the Train Platforming Problem in Busy Complex Passenger Stations

    Directory of Open Access Journals (Sweden)

    Qiongfang Zeng

    2017-09-01

    platforming problem (TPP by using mixed integer linear programming and job shop scheduling theory. First, the operation procedures and scheduled time adjustment costs of different train types specific to busy complex passenger stations are explicitly represented. Second, a multi-criteria scheduling model (MCS for TPP without earliness and tardiness time window (ETTW and a time window scheduling model (TWS with ETTW for TPP are proposed. Third, various dispatching rules were designed by incorporating the dispatcher experiences with modern scheduling theory and a rule-based metaheuristic to solve the above model is presented. With solution improvement strategies analogous to those used in practice by dispatchers, the realistic size problems in acceptable time can be solved.

  20. AN ACCURATE ORBITAL INTEGRATOR FOR THE RESTRICTED THREE-BODY PROBLEM AS A SPECIAL CASE OF THE DISCRETE-TIME GENERAL THREE-BODY PROBLEM

    International Nuclear Information System (INIS)

    Minesaki, Yukitaka

    2013-01-01

    For the restricted three-body problem, we propose an accurate orbital integration scheme that retains all conserved quantities of the two-body problem with two primaries and approximately preserves the Jacobi integral. The scheme is obtained by taking the limit as mass approaches zero in the discrete-time general three-body problem. For a long time interval, the proposed scheme precisely reproduces various periodic orbits that cannot be accurately computed by other generic integrators

  1. Silicon based cryogenic platform for the integration of qubit and classical control chips

    Science.gov (United States)

    Leonhardt, T.; Hollmann, A.; Jirovec, D.; Neumann, R.; Klemt, B.; Kindel, S.; Kucharski, M.; Fischer, G.; Bougeard, D.; Bluhm, H.; Schreiber, L. R.

    Electrostatically confined electron-spin-qubits proved viable for quantum information processing. Yet their up-scaling not only demands improvement of physical qubits, but also the development and cryogenic integration of classical control hardware. Therefore, we created a platform to integrate quantum chips and classical electronics. These multilayer interposer chips incorporate passive circuit elements, high bandwidth coplanar wave guides and interconnects for electron spin resonant qubit control as well as low impedance DC microstrips reducing EM-crosstalk from AC to DC lines. We used the interposer for measurements of a Si/SiGe quantum dot at 30 mK. We also characterized a commercial voltage controlled oszillator (VCO) based on hetero-bipolar transistors. Tunable about 30 GHz it is ideal for electron spin resonant qubit control. Cooled from 300 to 4 K it exhibits a slightly increased output power and frequency, while the phase noise level is constant. The device remains functional up to magnetic fields of 6 T.

  2. E-Center: A Collaborative Platform for Wide Area Network Users

    Science.gov (United States)

    Grigoriev, M.; DeMar, P.; Tierney, B.; Lake, A.; Metzger, J.; Frey, M.; Calyam, P.

    2012-12-01

    The E-Center is a social collaborative web-based platform for assisting network users in understanding network conditions across network paths of interest to them. It is designed to give a user the necessary tools to isolate, identify, and resolve network performance-related problems. E-Center provides network path information on a link-by-link level, as well as from an end-to-end perspective. In addition to providing current and recent network path data, E-Center is intended to provide a social media environment for them to share issues, ideas, concerns, and problems. The product has a modular design that accommodates integration of other network services that make use of the same network path and performance data.

  3. E-center: A collaborative platform for wide area network users

    Energy Technology Data Exchange (ETDEWEB)

    Grigoriev, M. [Fermilab; DeMar, P. [Fermilab; Tierney, B. [LBL, Berkeley; Lake, A. [LBL, Berkeley; Metzger, J. [LBL, Berkeley; Frey, M. [Bucknell U.; Calyam, P. [Ohio State U.

    2012-01-01

    The E-Center is a social collaborative web-based platform for assisting network users in understanding network conditions across network paths of interest to them. It is designed to give a user the necessary tools to isolate, identify, and resolve network performance-related problems. E-Center provides network path information on a link-by-link level, as well as from an end-to-end perspective. In addition to providing current and recent network path data, E-Center is intended to provide a social media environment for them to share issues, ideas, concerns, and problems. The product has a modular design that accommodates integration of other network services that make use of the same network path and performance data.

  4. E-Center: A Collaborative Platform for Wide Area Network Users

    International Nuclear Information System (INIS)

    Grigoriev, M; DeMar, P; Tierney, B; Lake, A; Metzger, J; Frey, M; Calyam, P

    2012-01-01

    The E-Center is a social collaborative web-based platform for assisting network users in understanding network conditions across network paths of interest to them. It is designed to give a user the necessary tools to isolate, identify, and resolve network performance-related problems. E-Center provides network path information on a link-by-link level, as well as from an end-to-end perspective. In addition to providing current and recent network path data, E-Center is intended to provide a social media environment for them to share issues, ideas, concerns, and problems. The product has a modular design that accommodates integration of other network services that make use of the same network path and performance data.

  5. A Comparison and Integration of MiSeq and MinION Platforms for Sequencing Single Source and Mixed Mitochondrial Genomes.

    Directory of Open Access Journals (Sweden)

    Michael R Lindberg

    Full Text Available Single source and multiple donor (mixed samples of human mitochondrial DNA were analyzed and compared using the MinION and the MiSeq platforms. A generalized variant detection strategy was employed to provide a cursory framework for evaluating the reliability and accuracy of mitochondrial sequences produced by the MinION. The feasibility of long-read phasing was investigated to establish its efficacy in quantitatively distinguishing and deconvolving individuals in a mixture. Finally, a proof-of-concept was demonstrated by integrating both platforms in a hybrid assembly that leverages solely mixture data to accurately reconstruct full mitochondrial genomes.

  6. Integrative multi-platform meta-analysis of gene expression profiles in pancreatic ductal adenocarcinoma patients for identifying novel diagnostic biomarkers.

    Science.gov (United States)

    Irigoyen, Antonio; Jimenez-Luna, Cristina; Benavides, Manuel; Caba, Octavio; Gallego, Javier; Ortuño, Francisco Manuel; Guillen-Ponce, Carmen; Rojas, Ignacio; Aranda, Enrique; Torres, Carolina; Prados, Jose

    2018-01-01

    Applying differentially expressed genes (DEGs) to identify feasible biomarkers in diseases can be a hard task when working with heterogeneous datasets. Expression data are strongly influenced by technology, sample preparation processes, and/or labeling methods. The proliferation of different microarray platforms for measuring gene expression increases the need to develop models able to compare their results, especially when different technologies can lead to signal values that vary greatly. Integrative meta-analysis can significantly improve the reliability and robustness of DEG detection. The objective of this work was to develop an integrative approach for identifying potential cancer biomarkers by integrating gene expression data from two different platforms. Pancreatic ductal adenocarcinoma (PDAC), where there is an urgent need to find new biomarkers due its late diagnosis, is an ideal candidate for testing this technology. Expression data from two different datasets, namely Affymetrix and Illumina (18 and 36 PDAC patients, respectively), as well as from 18 healthy controls, was used for this study. A meta-analysis based on an empirical Bayesian methodology (ComBat) was then proposed to integrate these datasets. DEGs were finally identified from the integrated data by using the statistical programming language R. After our integrative meta-analysis, 5 genes were commonly identified within the individual analyses of the independent datasets. Also, 28 novel genes that were not reported by the individual analyses ('gained' genes) were also discovered. Several of these gained genes have been already related to other gastroenterological tumors. The proposed integrative meta-analysis has revealed novel DEGs that may play an important role in PDAC and could be potential biomarkers for diagnosing the disease.

  7. An FPGA-based rapid prototyping platform for wavelet coprocessors

    Science.gov (United States)

    Vera, Alonzo; Meyer-Baese, Uwe; Pattichis, Marios

    2007-04-01

    MatLab/Simulink-based design flows are being used by DSP designers to improve time-to-market of FPGA implementations. 1 Commonly, digital signal processing cores are integrated in an embedded system as coprocessors. Existing CAD tools do not fully address the integration of a DSP coprocessor into an embedded system design. This integration might prove to be time consuming and error prone. It also requires that the DSP designer has an excellent knowledge of embedded systems and computer architecture details. We present a prototyping platform and design flow that allows rapid integration of embedded systems with a wavelet coprocessor. The platform comprises of software and hardware modules that allow a DSP designer a painless integration of a coprocessor with a PowerPC-based embedded system. The platform has a wide range of applications, from industrial to educational environments.

  8. Finding Common Ground: Use of a Geographically-Framed Landscape Template as an Integrating Platform for an International Education Initiative

    Science.gov (United States)

    Brierley, Gary; Li, Xilai; Qiao, Youming; Huang, He Qing; Wang, Zhaoyin

    2018-01-01

    This situated case study outlines how a place-based landscape template provided an integrative platform for the environmental arm of a cross-disciplinary international education initiative, the Three Brothers Project, wherein geographers at the University of Auckland worked alongside engineers at Tsinghua University in Beijing to support…

  9. IVAG: An Integrative Visualization Application for Various Types of Genomic Data Based on R-Shiny and the Docker Platform.

    Science.gov (United States)

    Lee, Tae-Rim; Ahn, Jin Mo; Kim, Gyuhee; Kim, Sangsoo

    2017-12-01

    Next-generation sequencing (NGS) technology has become a trend in the genomics research area. There are many software programs and automated pipelines to analyze NGS data, which can ease the pain for traditional scientists who are not familiar with computer programming. However, downstream analyses, such as finding differentially expressed genes or visualizing linkage disequilibrium maps and genome-wide association study (GWAS) data, still remain a challenge. Here, we introduce a dockerized web application written in R using the Shiny platform to visualize pre-analyzed RNA sequencing and GWAS data. In addition, we have integrated a genome browser based on the JBrowse platform and an automated intermediate parsing process required for custom track construction, so that users can easily build and navigate their personal genome tracks with in-house datasets. This application will help scientists perform series of downstream analyses and obtain a more integrative understanding about various types of genomic data by interactively visualizing them with customizable options.

  10. Integrating routing decisions in public transportation problems

    CERN Document Server

    Schmidt, Marie E

    2014-01-01

    This book treats three planning problems arising in public railway transportation planning: line planning, timetabling, and delay management, with the objective to minimize passengers’ travel time. While many optimization approaches simplify these problems by assuming that passengers’ route choice is independent of the solution, this book focuses on models which take into account that passengers will adapt their travel route to the implemented planning solution. That is, a planning solution and passengers’ routes are determined and evaluated simultaneously. This work is technically deep, with insightful findings regarding complexity and algorithmic approaches to public transportation problems with integrated passenger routing. It is intended for researchers in the fields of mathematics, computer science, or operations research, working in the field of public transportation from an optimization standpoint. It is also ideal for students who want to gain intuition and experience in doing complexity proofs ...

  11. An integrated biomedical knowledge extraction and analysis platform: using federated search and document clustering technology.

    Science.gov (United States)

    Taylor, Donald P

    2007-01-01

    High content screening (HCS) requires time-consuming and often complex iterative information retrieval and assessment approaches to optimally conduct drug discovery programs and biomedical research. Pre- and post-HCS experimentation both require the retrieval of information from public as well as proprietary literature in addition to structured information assets such as compound libraries and projects databases. Unfortunately, this information is typically scattered across a plethora of proprietary bioinformatics tools and databases and public domain sources. Consequently, single search requests must be presented to each information repository, forcing the results to be manually integrated for a meaningful result set. Furthermore, these bioinformatics tools and data repositories are becoming increasingly complex to use; typically they fail to allow for more natural query interfaces. Vivisimo has developed an enterprise software platform to bridge disparate silos of information. The platform automatically categorizes search results into descriptive folders without the use of taxonomies to drive the categorization. A new approach to information retrieval for HCS experimentation is proposed.

  12. Computer integration in the curriculum: promises and problems

    NARCIS (Netherlands)

    Plomp, T.; van den Akker, Jan

    1988-01-01

    This discussion of the integration of computers into the curriculum begins by reviewing the results of several surveys conducted in the Netherlands and the United States which provide insight into the problems encountered by schools and teachers when introducing computers in education. Case studies

  13. Citizen Sensors for SHM: Towards a Crowdsourcing Platform

    Science.gov (United States)

    Ozer, Ekin; Feng, Maria Q.; Feng, Dongming

    2015-01-01

    This paper presents an innovative structural health monitoring (SHM) platform in terms of how it integrates smartphone sensors, the web, and crowdsourcing. The ubiquity of smartphones has provided an opportunity to create low-cost sensor networks for SHM. Crowdsourcing has given rise to citizen initiatives becoming a vast source of inexpensive, valuable but heterogeneous data. Previously, the authors have investigated the reliability of smartphone accelerometers for vibration-based SHM. This paper takes a step further to integrate mobile sensing and web-based computing for a prospective crowdsourcing-based SHM platform. An iOS application was developed to enable citizens to measure structural vibration and upload the data to a server with smartphones. A web-based platform was developed to collect and process the data automatically and store the processed data, such as modal properties of the structure, for long-term SHM purposes. Finally, the integrated mobile and web-based platforms were tested to collect the low-amplitude ambient vibration data of a bridge structure. Possible sources of uncertainties related to citizens were investigated, including the phone location, coupling conditions, and sampling duration. The field test results showed that the vibration data acquired by smartphones operated by citizens without expertise are useful for identifying structural modal properties with high accuracy. This platform can be further developed into an automated, smart, sustainable, cost-free system for long-term monitoring of structural integrity of spatially distributed urban infrastructure. Citizen Sensors for SHM will be a novel participatory sensing platform in the way that it offers hybrid solutions to transitional crowdsourcing parameters. PMID:26102490

  14. Citizen Sensors for SHM: Towards a Crowdsourcing Platform

    Directory of Open Access Journals (Sweden)

    Ekin Ozer

    2015-06-01

    Full Text Available This paper presents an innovative structural health monitoring (SHM platform in terms of how it integrates smartphone sensors, the web, and crowdsourcing. The ubiquity of smartphones has provided an opportunity to create low-cost sensor networks for SHM. Crowdsourcing has given rise to citizen initiatives becoming a vast source of inexpensive, valuable but heterogeneous data. Previously, the authors have investigated the reliability of smartphone accelerometers for vibration-based SHM. This paper takes a step further to integrate mobile sensing and web-based computing for a prospective crowdsourcing-based SHM platform. An iOS application was developed to enable citizens to measure structural vibration and upload the data to a server with smartphones. A web-based platform was developed to collect and process the data automatically and store the processed data, such as modal properties of the structure, for long-term SHM purposes. Finally, the integrated mobile and web-based platforms were tested to collect the low-amplitude ambient vibration data of a bridge structure. Possible sources of uncertainties related to citizens were investigated, including the phone location, coupling conditions, and sampling duration. The field test results showed that the vibration data acquired by smartphones operated by citizens without expertise are useful for identifying structural modal properties with high accuracy. This platform can be further developed into an automated, smart, sustainable, cost-free system for long-term monitoring of structural integrity of spatially distributed urban infrastructure. Citizen Sensors for SHM will be a novel participatory sensing platform in the way that it offers hybrid solutions to transitional crowdsourcing parameters.

  15. Platform development: implications for portfolio management

    DEFF Research Database (Denmark)

    Hsuan, Juliana; Hansen, Poul H. Kyvsgård

    2007-01-01

    " The challenge of implementing industrial platforms in practice can be described as a configuration problem caused by a considerable number of variables, which often have contradictory influences on the total performance of the firm. Consequently, the specific platform decisions become extremely...... complex, possibly increasing the strategic risks for the firm. This paper reports preliminary findings on platform management process at LEGO, a Danish toy company. Specifically, we report the process of applying games combined with simulations and workshops in the platform development. We also propose...... a framework, based on the portfolio management thinking to evaluate the degree of modularity embedded in a given platform and to which extent it is aligned with other platforms."...

  16. USA Hire Testing Platform

    Data.gov (United States)

    Office of Personnel Management — The USA Hire Testing Platform delivers tests used in hiring for positions in the Federal Government. To safeguard the integrity of the hiring processes and ensure...

  17. Fundamental framework toward optimal design of product platform for industrial three-axis linear-type robots

    Directory of Open Access Journals (Sweden)

    Kana Sawai

    2015-07-01

    Full Text Available This paper discusses an optimization-based approach for the design of a product platform for industrial three-axis linear-type robots, which are widely used for handling objects in manufacturing lines. Since the operational specifications of these robots, such as operation speed, working distance and orientation, weight and shape of loads, etc., will vary for different applications, robotic system vendors must provide various types of robots efficiently and effectively to meet a range of market needs. A promising step toward this goal is the concept of a product platform, in which several key elements are commonly used across a series of products, which can then be customized for individual requirements. However the design of a product platform is more complicated than that of each product, due to the need to optimize the design across many products. This paper proposes an optimization-based fundamental framework toward the design of a product platform for industrial three-axis linear-type robots; this framework allows the solution of a complicated design problem and builds an optimal design method of fundamental features of robot frames that are commonly used for a wide range of robots. In this formulation, some key performance metrics of the robot are estimated by a reduced-order model which is configured with beam theory. A multi-objective optimization problem is formulated to represent the trade-offs among key design parameters using a weighted-sum form for a single product. This formulation is integrated into a mini–max type optimization problem across a series of robots as an optimal design formulation for the product platform. Some case studies of optimal platform design for industrial three-axis linear-type robots are presented to demonstrate the applications of a genetic algorithm to such mathematical models.

  18. Health-e-Child a grid platform for european paediatrics

    CERN Document Server

    Skaburskas, K; Shade, J; Manset, D; Revillard, J; Rios, A; Anjum, A; Branson, A; Bloodsworth, P; Hauer, T; McClatchey, R; Rogulin, D

    2008-01-01

    The Health-e-Child (HeC) project [1], [2] is an EC Framework Programme 6 Integrated Project that aims to develop a grid-based integrated healthcare platform for paediatrics. Using this platform biomedical informaticians will integrate heterogeneous data and perform epidemiological studies across Europe. The resulting Grid enabled biomedical information platform will be supported by robust search, optimization and matching techniques for information collected in hospitals across Europe. In particular, paediatricians will be provided with decision support, knowledge discovery and disease modelling applications that will access data in hospitals in the UK, Italy and France, integrated via the Grid. For economy of scale, reusability, extensibility, and maintainability, HeC is being developed on top of an EGEE/gLite [3] based infrastructure that provides all the common data and computation management services required by the applications. This paper discusses some of the major challenges in bio-medical data integr...

  19. SAR system development for UAV multicopter platforms

    OpenAIRE

    Escartin Martínez, Antonio

    2015-01-01

    SAR system development for UAV multicopter platforms This thesis describes the optimization of a synthetic aperture radar (SAR) at X-band and its integration into an unmanned aerial vehicle (UAV) of type octocopter. For such optimization the SAR system functionality was extended from singlepol to fulpol and it has been optimized at hardware level in order to improve its quality against noise figure. After its integration into the octocopter platform, its features has been used in order to ...

  20. Integrating Global Learning into a Psychology Course Using an Online Platform

    Science.gov (United States)

    Forden, Carie L.; Carrillo, Amy M.

    2014-01-01

    There is a demand for the integration of global learning/diversity across the curriculum. A series of cross-cultural assignments was created to facilitate global learning in two social psychology classes, one in Egypt, and one in the USA. In these assignments, students collected data and applied course concepts to real-life problems, then…

  1. APPLICATION OF BOUNDARY INTEGRAL EQUATION METHOD FOR THERMOELASTICITY PROBLEMS

    Directory of Open Access Journals (Sweden)

    Vorona Yu.V.

    2015-12-01

    Full Text Available Boundary Integral Equation Method is used for solving analytically the problems of coupled thermoelastic spherical wave propagation. The resulting mathematical expressions coincide with the solutions obtained in a conventional manner.

  2. Migration of the Almaraz NPP integrated operation management system to a new computer platform

    International Nuclear Information System (INIS)

    Gonzalez Crego, E.; Martin Lopez-Suevos, C.

    1996-01-01

    In all power plants, it becomes necessary, with the passage of time, to migrate the initial operation management systems to adapt them to current technologies. That is a good time to improve the inclusion of data in the corporative database and standardize the system interfaces and operation, whilst maintaining data system operability. This article contains Almaraz experience in migrating its Integrated Operation Management System to an advanced computer platform based on open systems (UNIX), communications network (ETHERNET) and database (ORACLE). To this effect, clear objectives and strict standards were established to facilitate the work. The most noteworthy results obtained are: Better quality of information and structure in the corporative database Standardised user interface in all applications. Joint migration of applications for Maintenance, Components and Spare parts, Warehouses and Purchases. Integration of new applications into the system. Introduction of the navigator, which allows movement around the database using all available applications. (Author)

  3. EPOS Thematic Core Service ANTHROPOGENIC HAZARDS (TCS AH) - development of e-research platform

    Science.gov (United States)

    Orlecka-Sikora, Beata

    2017-04-01

    TCS AH is based on IS-EPOS Platform. The Platform facilitates research on anthropogenic hazards and is available online, free of charge https://tcs.ah-epos.eu/. The Platform is a final product of the IS-EPOS project, founded by the national programme - POIG - which was implemented in 2013-2015 (POIG.02.03.00-14-090/13-00). The platform is a result of a joint work of scientific community and industrial partners. Currently, the development of TCS AH is carried under EPOS IP project (H2020-INFRADEV-1-2015-1, INFRADEV-3-2015). Platform is an open virtual access point for researchers and Ph. D. students interested in anthropogenic seismicity and related hazards. This environment is designed to ensure a researcher the maximum possible liberty for experimentation by providing a virtual laboratory, in which the researcher can design own processing streams and process the data integrated on the platform. TCS AH integrates: data and specific high-level services. Data gathered in the so-called "episodes", comprehensively describing a geophysical process, induced or triggered by human technological activity, which, under certain circumstances can become hazardous for people, infrastructure and the environment. 7 sets of seismic, geological and technological data were made available on the Platform. The data come from Poland, Germany, UK and Vietnam, and refer to underground mining, reservoir impoundment, shale gas exploitation and geothermal energy production. The next at least 19 new episodes related to conventional hydrocarbon extraction, reservoir treatment, underground mining and geothermal energy production are being integrated within the framework of EPOS IP project. The heterogeneous multi-disciplinary data (seismic, displacement, geomechanical data, production data etc.) are transformed to unified structures to form integrated and validated datasets. To deal with this various data the problem-oriented services were designed and implemented. The particular attention

  4. Platform decisions supported by gaming

    DEFF Research Database (Denmark)

    Hansen, Poul H. Kyvsgård; Mikkola, Juliana Hsuan

    2007-01-01

    Platform is an ambiguous multidisciplinary concept. The philosophy behind it is easy to communicate and makes intuitively sense. However, the ease in communication does overshadow the high complexity when the concept is implemented. The practical industrial platform implementation challenge can...... be described as being a configuration problem with a high number of variables. These variables are different in nature; they have contradictory influence on the total performance, and, their importance change over time. Consequently, the specific platform decisions become highly complex and the consequences...

  5. The integration problem: Interlacing language, action and perception

    DEFF Research Database (Denmark)

    Cowley, Stephen

    2014-01-01

    Human thinking uses other peoples' experience. While often pictured as computation or based on the workings of a language-system in the mind or brain, the evidence suggests alternatives to representationalism. In terms proposed here, embodiment is interlaced with wordings as people tackle...... the integration problem. Using a case study, the paper shows how a young man uses external resources in an experimental task. He grasps a well-defined problem by using material resources, talking about his doings and switching roles and procedures. Attentional skills enable him to act as an air cadet who, among...

  6. Mobile Prototyping Platforms for Remote Engineering Applications

    Directory of Open Access Journals (Sweden)

    Karsten Henke

    2009-08-01

    Full Text Available This paper describes a low-cost mobile communication platform as a universal rapid-prototyping system, which is based on the Quadrocopter concept. At the Integrated Hardware and Software Systems Group at the Ilmenau University of Technology these mobile platforms are used to motivate bachelor and master students to study Computer Engineering sciences. This could be done by increasing their interest in technical issues, using this platform as integral part of a new ad-hoc lab to demonstrate different aspects in the area of Mobile Communication as well as universal rapid prototyping nodes to investigate different mechanisms for self-organized mobile communication systems within the International Graduate School on Mobile Communications. Beside the three fields of application, the paper describes the current architecture concept of the mobile prototyping platform as well as the chosen control mechanism and the assigned sensor systems to fulfill all the required tasks.

  7. Automics: an integrated platform for NMR-based metabonomics spectral processing and data analysis

    Directory of Open Access Journals (Sweden)

    Qu Lijia

    2009-03-01

    Full Text Available Abstract Background Spectral processing and post-experimental data analysis are the major tasks in NMR-based metabonomics studies. While there are commercial and free licensed software tools available to assist these tasks, researchers usually have to use multiple software packages for their studies because software packages generally focus on specific tasks. It would be beneficial to have a highly integrated platform, in which these tasks can be completed within one package. Moreover, with open source architecture, newly proposed algorithms or methods for spectral processing and data analysis can be implemented much more easily and accessed freely by the public. Results In this paper, we report an open source software tool, Automics, which is specifically designed for NMR-based metabonomics studies. Automics is a highly integrated platform that provides functions covering almost all the stages of NMR-based metabonomics studies. Automics provides high throughput automatic modules with most recently proposed algorithms and powerful manual modules for 1D NMR spectral processing. In addition to spectral processing functions, powerful features for data organization, data pre-processing, and data analysis have been implemented. Nine statistical methods can be applied to analyses including: feature selection (Fisher's criterion, data reduction (PCA, LDA, ULDA, unsupervised clustering (K-Mean and supervised regression and classification (PLS/PLS-DA, KNN, SIMCA, SVM. Moreover, Automics has a user-friendly graphical interface for visualizing NMR spectra and data analysis results. The functional ability of Automics is demonstrated with an analysis of a type 2 diabetes metabolic profile. Conclusion Automics facilitates high throughput 1D NMR spectral processing and high dimensional data analysis for NMR-based metabonomics applications. Using Automics, users can complete spectral processing and data analysis within one software package in most cases

  8. Automics: an integrated platform for NMR-based metabonomics spectral processing and data analysis.

    Science.gov (United States)

    Wang, Tao; Shao, Kang; Chu, Qinying; Ren, Yanfei; Mu, Yiming; Qu, Lijia; He, Jie; Jin, Changwen; Xia, Bin

    2009-03-16

    Spectral processing and post-experimental data analysis are the major tasks in NMR-based metabonomics studies. While there are commercial and free licensed software tools available to assist these tasks, researchers usually have to use multiple software packages for their studies because software packages generally focus on specific tasks. It would be beneficial to have a highly integrated platform, in which these tasks can be completed within one package. Moreover, with open source architecture, newly proposed algorithms or methods for spectral processing and data analysis can be implemented much more easily and accessed freely by the public. In this paper, we report an open source software tool, Automics, which is specifically designed for NMR-based metabonomics studies. Automics is a highly integrated platform that provides functions covering almost all the stages of NMR-based metabonomics studies. Automics provides high throughput automatic modules with most recently proposed algorithms and powerful manual modules for 1D NMR spectral processing. In addition to spectral processing functions, powerful features for data organization, data pre-processing, and data analysis have been implemented. Nine statistical methods can be applied to analyses including: feature selection (Fisher's criterion), data reduction (PCA, LDA, ULDA), unsupervised clustering (K-Mean) and supervised regression and classification (PLS/PLS-DA, KNN, SIMCA, SVM). Moreover, Automics has a user-friendly graphical interface for visualizing NMR spectra and data analysis results. The functional ability of Automics is demonstrated with an analysis of a type 2 diabetes metabolic profile. Automics facilitates high throughput 1D NMR spectral processing and high dimensional data analysis for NMR-based metabonomics applications. Using Automics, users can complete spectral processing and data analysis within one software package in most cases. Moreover, with its open source architecture, interested

  9. SEMIGROUPS N TIMES INTEGRATED AND AN APPLICATION TO A PROBLEM OF CAUCHY TYPE

    Directory of Open Access Journals (Sweden)

    Danessa Chirinos Fernández

    2016-06-01

    Full Text Available The theory of semigroups n times integrated is a generalization of strongly continuous semigroups, which was developed from 1984, and is widely used for the study of the existence and uniqueness of problems such Cauchy in which the operator domain is not necessarily dense. This paper presents an application of semigroups n times integrated into a problem of viscoelasticity, which is formulated as a Cauchy problem on a Banach space presents .

  10. Advances in the development of the Mexican platform for analysis and design of nuclear reactors: AZTLAN Platform

    International Nuclear Information System (INIS)

    Gomez T, A. M.; Puente E, F.; Del Valle G, E.; Francois L, J. L.; Espinosa P, G.

    2017-09-01

    The AZTLAN platform project: development of a Mexican platform for the analysis and design of nuclear reactors, financed by the SENER-CONACYT Energy Sustain ability Fund, was approved in early 2014 and formally began at the end of that year. It is a national project led by the Instituto Nacional de Investigaciones Nucleares (ININ) and with the collaboration of Instituto Politecnico Nacional (IPN), the Universidad Autonoma Metropolitana (UAM) and Universidad Nacional Autonoma de Mexico (UNAM) as part of the development team and with the participation of the Laguna Verde Nuclear Power Plant, the National Commission of Nuclear Safety and Safeguards, the Ministry of Energy and the Karlsruhe Institute of Technology (Kit, Germany) as part of the user group. The general objective of the project is to modernize, improve and integrate the neutronic, thermo-hydraulic and thermo-mechanical codes, developed in Mexican institutions, in an integrated platform, developed and maintained by Mexican experts for the benefit of Mexican institutions. Two years into the process, important steps have been taken that have consolidated the platform. The main results of these first two years have been presented in different national and international forums. In this congress, some of the most recent results that have been implemented in the platform codes are shown in more detail. The current status of the platform from a more executive view point is summarized in this paper. (Author)

  11. Internet of things platforms in support of smart cities infrastructures

    CSIR Research Space (South Africa)

    Dlodlo, N

    2013-09-01

    Full Text Available the real and virtual worlds. This has been made possible through the development of IoT platforms. A city is referred to as ‘smart’ if it integrates smart objects into its products and services. The challenge is to integrate IoT platforms into the smart...

  12. A stiffly accurate integrator for elastodynamic problems

    KAUST Repository

    Michels, Dominik L.

    2017-07-21

    We present a new integration algorithm for the accurate and efficient solution of stiff elastodynamic problems governed by the second-order ordinary differential equations of structural mechanics. Current methods have the shortcoming that their performance is highly dependent on the numerical stiffness of the underlying system that often leads to unrealistic behavior or a significant loss of efficiency. To overcome these limitations, we present a new integration method which is based on a mathematical reformulation of the underlying differential equations, an exponential treatment of the full nonlinear forcing operator as opposed to more standard partially implicit or exponential approaches, and the utilization of the concept of stiff accuracy which ensures that the efficiency of the simulations is significantly less sensitive to increased stiffness. As a consequence, we are able to tremendously accelerate the simulation of stiff systems compared to established integrators and significantly increase the overall accuracy. The advantageous behavior of this approach is demonstrated on a broad spectrum of complex examples like deformable bodies, textiles, bristles, and human hair. Our easily parallelizable integrator enables more complex and realistic models to be explored in visual computing without compromising efficiency.

  13. Design and development of a device management platform for EAST cryogenic system

    Energy Technology Data Exchange (ETDEWEB)

    Zhou, Zhiwei, E-mail: zzw@ipp.ac.cn; Lu, Xiaofei, E-mail: xiaofeilu@ipp.ac.cn; Zhuang, Ming, E-mail: zhm@ipp.ac.cn; Hu, Liangbing, E-mail: huliangbing@ipp.ac.cn; Xia, Genhai, E-mail: xgh@ipp.ac.cn

    2014-05-15

    Highlights: • A device management platform for EAST cryogenic system based on DCS is designed. • This platform enhances the integrity and continuity of system device information. • It can help predictive maintenance and device management decision. - Abstract: EAST cryogenic system is one of the critical sub-systems of the EAST tokamak device. It is a large scale helium cryoplant, which adopts distributed control system to realize monitoring and control of the cryogenic process and devices. However, the maintenance and management of most field devices are still in the corrective maintenance or traditional preventive maintenance stage. Under maintained or over maintained problems widely exist, which could cause devices fault and increase operation costs. Therefore, a device management platform is proposed for a safe and steady operation as well as fault diagnosis and predictive maintenance of EAST cryogenic system. This paper presents the function design and architecture design of the cryogenic device management platform. This platform is developed based on DeltaV DCS and acquires monitoring data through OPC protocol. It consists of three pillars, namely device information management, device condition management, and device performance monitoring. The development and implementation of every pillar are illustrated in detail in this paper. Test results and discussions are presented in the end.

  14. 2011 Biomass Program Platform Peer Review. Integrated Biorefineries

    Energy Technology Data Exchange (ETDEWEB)

    Rossmeissl, Neil [Office of Energy Efficiency and Renewable Energy (EERE), Washington, DC (United States)

    2012-02-01

    This document summarizes the recommendations and evaluations provided by an independent external panel of experts at the 2011 U.S. Department of Energy Biomass Program’s IBR Platform Review meeting.

  15. Learner Perspectives of Online Problem-Based Learning and Applications from Cognitive Load Theory

    Science.gov (United States)

    Chen, Ruth

    2016-01-01

    Problem-based learning (PBL) courses have historically been situated in physical classrooms involving in-person interactions. As online learning is embraced in higher education, programs that use PBL can integrate online platforms to support curriculum delivery and facilitate student engagement. This report describes student perspectives of the…

  16. Academic and social integration and study progress in problem based learning

    NARCIS (Netherlands)

    S.E. Severiens (Sabine); H.G. Schmidt (Henk)

    2009-01-01

    textabstractThe present study explores the effects of problem-based learning (PBL) on social and academic integration and study progress. Three hundred and five first-year students from three different psychology curricula completed a questionnaire on social and academic integration. Effects of a

  17. Interfaces and Integration of Medical Image Analysis Frameworks: Challenges and Opportunities.

    Science.gov (United States)

    Covington, Kelsie; McCreedy, Evan S; Chen, Min; Carass, Aaron; Aucoin, Nicole; Landman, Bennett A

    2010-05-25

    Clinical research with medical imaging typically involves large-scale data analysis with interdependent software toolsets tied together in a processing workflow. Numerous, complementary platforms are available, but these are not readily compatible in terms of workflows or data formats. Both image scientists and clinical investigators could benefit from using the framework which is a most natural fit to the specific problem at hand, but pragmatic choices often dictate that a compromise platform is used for collaboration. Manual merging of platforms through carefully tuned scripts has been effective, but exceptionally time consuming and is not feasible for large-scale integration efforts. Hence, the benefits of innovation are constrained by platform dependence. Removing this constraint via integration of algorithms from one framework into another is the focus of this work. We propose and demonstrate a light-weight interface system to expose parameters across platforms and provide seamless integration. In this initial effort, we focus on four platforms Medical Image Analysis and Visualization (MIPAV), Java Image Science Toolkit (JIST), command line tools, and 3D Slicer. We explore three case studies: (1) providing a system for MIPAV to expose internal algorithms and utilize these algorithms within JIST, (2) exposing JIST modules through self-documenting command line interface for inclusion in scripting environments, and (3) detecting and using JIST modules in 3D Slicer. We review the challenges and opportunities for light-weight software integration both within development language (e.g., Java in MIPAV and JIST) and across languages (e.g., C/C++ in 3D Slicer and shell in command line tools).

  18. Problem solving strategies integrated into nursing process to promote clinical problem solving abilities of RN-BSN students.

    Science.gov (United States)

    Wang, Jing-Jy; Lo, Chi-Hui Kao; Ku, Ya-Lie

    2004-11-01

    A set of problem solving strategies integrated into nursing process in nursing core courses (PSNP) was developed for students enrolled in a post-RN baccalaureate nursing program (RN-BSN) in a university in Taiwan. The purpose of this study, therefore, was to evaluate the effectiveness of PSNP on students' clinical problem solving abilities. The one-group post-test design with repeated measures was used. In total 114 nursing students with 47 full-time students and 67 part-time students participated in this study. The nursing core courses were undertaken separately in three semesters. After each semester's learning, students would start their clinical practice, and were asked to submit three written nursing process recordings during each clinic. Assignments from the three practices were named post-test I, II, and III sequentially, and provided the data for this study. The overall score of problem solving indicated that score on the post-test III was significantly better than that on post-test I and II, meaning both full-time and part-time students' clinical problem solving abilities improved at the last semester. In conclusion, problem-solving strategies integrated into nursing process designed for future RN-BSN students are recommendable.

  19. Multidimensional integral representations problems of analytic continuation

    CERN Document Server

    Kytmanov, Alexander M

    2015-01-01

    The monograph is devoted to integral representations for holomorphic functions in several complex variables, such as Bochner-Martinelli, Cauchy-Fantappiè, Koppelman, multidimensional logarithmic residue etc., and their boundary properties. The applications considered are problems of analytic continuation of functions from the boundary of a bounded domain in C^n. In contrast to the well-known Hartogs-Bochner theorem, this book investigates functions with the one-dimensional property of holomorphic extension along complex lines, and includes the problems of receiving multidimensional boundary analogs of the Morera theorem.   This book is a valuable resource for specialists in complex analysis, theoretical physics, as well as graduate and postgraduate students with an understanding of standard university courses in complex, real and functional analysis, as well as algebra and geometry.

  20. Integration of problem-based learning and innovative technology into a self-care course.

    Science.gov (United States)

    McFalls, Marsha

    2013-08-12

    To assess the integration of problem-based learning and technology into a self-care course. Problem-based learning (PBL) activities were developed and implemented in place of lectures in a self-care course. Students used technology, such as computer-generated virtual patients and iPads, during the PBL sessions. Students' scores on post-case quizzes were higher than on pre-case quizzes used to assess baseline knowledge. Student satisfaction with problem-based learning and the use of technology in the course remained consistent throughout the semester. Integrating problem-based learning and technology into a self-care course enabled students to become active learners.

  1. [Problems of world outlook and methodology of science integration in biological studies].

    Science.gov (United States)

    Khododova, Iu D

    1981-01-01

    Problems of worldoutlook and methodology of the natural-science knowledge are considered basing on the analysis of tendencies in the development of the membrane theory of cell processes and the use of principles of biological membrane functioning when solving some scientific and applied problems pertaining to different branches of chemistry and biology. The notion scientific knowledge integration is defined as interpenetration of approaches, methods and ideas of different branches of knowledge and enrichment on this basis of their content resulting in knowledge augmentation in each field taken separately. These processes are accompanied by appearance of new branches of knowledge - sciences "on junction" and their subsequent differentiations. The analysis of some gnoseological situations shows that integration of sciences contributes to coordination and some agreement of thinking styles of different specialists, puts forward keen personality of a scientist demanding, in particular, his high professional mobility. Problems of scientific activity organization are considered, which involve social sciences into the integration processes. The role of philosophy in the integration processes is emphasized.

  2. Development of an Integrated Process, Modeling and Simulation Platform for Performance-Based Design of Low-Energy and High IEQ Buildings

    Science.gov (United States)

    Chen, Yixing

    2013-01-01

    The objective of this study was to develop a "Virtual Design Studio (VDS)": a software platform for integrated, coordinated and optimized design of green building systems with low energy consumption, high indoor environmental quality (IEQ), and high level of sustainability. The VDS is intended to assist collaborating architects,…

  3. S-bases as a tool to solve reduction problems for Feynman integrals

    International Nuclear Information System (INIS)

    Smirnov, A.V.; Smirnov, V.A.

    2006-01-01

    We suggest a mathematical definition of the notion of master integrals and present a brief review of algorithmic methods to solve reduction problems for Feynman integrals based on integration by parts relations. In particular, we discuss a recently suggested reduction algorithm which uses Groebner bases. New results obtained with its help for a family of three-loop Feynman integrals are outlined

  4. S-bases as a tool to solve reduction problems for Feynman integrals

    Energy Technology Data Exchange (ETDEWEB)

    Smirnov, A.V. [Scientific Research Computing Center of Moscow State University, Moscow 119992 (Russian Federation); Smirnov, V.A. [Nuclear Physics Institute of Moscow State University, Moscow 119992 (Russian Federation)

    2006-10-15

    We suggest a mathematical definition of the notion of master integrals and present a brief review of algorithmic methods to solve reduction problems for Feynman integrals based on integration by parts relations. In particular, we discuss a recently suggested reduction algorithm which uses Groebner bases. New results obtained with its help for a family of three-loop Feynman integrals are outlined.

  5. OTEC platform configuration and integration. Appendixes to Volume II. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Price, David

    1978-07-07

    Detailed information and conceptual design drawings for the SPAR and SPHERE platforms for an OTEC commercial plant are presented. A work breakdown structure and a detailed estimate of the SPAR platform weight are included. (WHK)

  6. CNV Workshop: an integrated platform for high-throughput copy number variation discovery and clinical diagnostics.

    Science.gov (United States)

    Gai, Xiaowu; Perin, Juan C; Murphy, Kevin; O'Hara, Ryan; D'arcy, Monica; Wenocur, Adam; Xie, Hongbo M; Rappaport, Eric F; Shaikh, Tamim H; White, Peter S

    2010-02-04

    Recent studies have shown that copy number variations (CNVs) are frequent in higher eukaryotes and associated with a substantial portion of inherited and acquired risk for various human diseases. The increasing availability of high-resolution genome surveillance platforms provides opportunity for rapidly assessing research and clinical samples for CNV content, as well as for determining the potential pathogenicity of identified variants. However, few informatics tools for accurate and efficient CNV detection and assessment currently exist. We developed a suite of software tools and resources (CNV Workshop) for automated, genome-wide CNV detection from a variety of SNP array platforms. CNV Workshop includes three major components: detection, annotation, and presentation of structural variants from genome array data. CNV detection utilizes a robust and genotype-specific extension of the Circular Binary Segmentation algorithm, and the use of additional detection algorithms is supported. Predicted CNVs are captured in a MySQL database that supports cohort-based projects and incorporates a secure user authentication layer and user/admin roles. To assist with determination of pathogenicity, detected CNVs are also annotated automatically for gene content, known disease loci, and gene-based literature references. Results are easily queried, sorted, filtered, and visualized via a web-based presentation layer that includes a GBrowse-based graphical representation of CNV content and relevant public data, integration with the UCSC Genome Browser, and tabular displays of genomic attributes for each CNV. To our knowledge, CNV Workshop represents the first cohesive and convenient platform for detection, annotation, and assessment of the biological and clinical significance of structural variants. CNV Workshop has been successfully utilized for assessment of genomic variation in healthy individuals and disease cohorts and is an ideal platform for coordinating multiple associated

  7. CNV Workshop: an integrated platform for high-throughput copy number variation discovery and clinical diagnostics

    Directory of Open Access Journals (Sweden)

    Rappaport Eric F

    2010-02-01

    Full Text Available Abstract Background Recent studies have shown that copy number variations (CNVs are frequent in higher eukaryotes and associated with a substantial portion of inherited and acquired risk for various human diseases. The increasing availability of high-resolution genome surveillance platforms provides opportunity for rapidly assessing research and clinical samples for CNV content, as well as for determining the potential pathogenicity of identified variants. However, few informatics tools for accurate and efficient CNV detection and assessment currently exist. Results We developed a suite of software tools and resources (CNV Workshop for automated, genome-wide CNV detection from a variety of SNP array platforms. CNV Workshop includes three major components: detection, annotation, and presentation of structural variants from genome array data. CNV detection utilizes a robust and genotype-specific extension of the Circular Binary Segmentation algorithm, and the use of additional detection algorithms is supported. Predicted CNVs are captured in a MySQL database that supports cohort-based projects and incorporates a secure user authentication layer and user/admin roles. To assist with determination of pathogenicity, detected CNVs are also annotated automatically for gene content, known disease loci, and gene-based literature references. Results are easily queried, sorted, filtered, and visualized via a web-based presentation layer that includes a GBrowse-based graphical representation of CNV content and relevant public data, integration with the UCSC Genome Browser, and tabular displays of genomic attributes for each CNV. Conclusions To our knowledge, CNV Workshop represents the first cohesive and convenient platform for detection, annotation, and assessment of the biological and clinical significance of structural variants. CNV Workshop has been successfully utilized for assessment of genomic variation in healthy individuals and disease cohorts and

  8. Development and Application of integrated monitoring platform for the Doppler Weather SA-BAND Radar

    Science.gov (United States)

    Zhang, Q.; Sun, J.; Zhao, C. C.; Chen, H. Y.

    2017-10-01

    The doppler weather SA-band radar is an important part of modern meteorological observation methods, monitoring the running status of radar and the data transmission is important.This paper introduced the composition of radar system and classification of radar data,analysed the characteristics and laws of the radar when is normal or abnormal. Using Macromedia Dreamweaver and PHP, developed the integrated monitoring platform for the doppler weather SA-band radar which could monitor the real-time radar system running status and important performance indicators such as radar power,status parameters and others on Web page,and when the status is abnormal it will trigger the audio alarm.

  9. A Sol-gel Integrated Dual-readout Microarray Platform for Quantification and Identification of Prostate-specific Antigen.

    Science.gov (United States)

    Lee, SangWook; Lee, Jong Hyun; Kwon, Hyuck Gi; Laurell, Thomas; Jeong, Ok Chan; Kim, Soyoun

    2018-01-01

    Here, we report a sol-gel integrated affinity microarray for on-chip matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) that enables capture and identification of prostate?specific antigen (PSA) in samples. An anti-PSA antibody (H117) was mixed with a sol?gel, and the mixture was spotted onto a porous silicon (pSi) surface without additional surface modifications. The antibody easily penetrates the sol-gel macropore fluidic network structure, making possible high affinities. To assess the capture affinity of the platform, we performed a direct assay using fluorescein isothiocyanate-labeled PSA. Pure PSA was subjected to on-chip MALDI-TOF-MS analysis, yielding three clear mass peptide peaks (m/z = 1272, 1407, and 1872). The sol-gel microarray platform enables dual readout of PSA both fluorometric and MALDI-TOF MS analysis in biological samples. Here we report a useful method for a means for discovery of biomarkers in complex body fluids.

  10. Applications integration in a hybrid cloud computing environment: modelling and platform

    Science.gov (United States)

    Li, Qing; Wang, Ze-yuan; Li, Wei-hua; Li, Jun; Wang, Cheng; Du, Rui-yang

    2013-08-01

    With the development of application services providers and cloud computing, more and more small- and medium-sized business enterprises use software services and even infrastructure services provided by professional information service companies to replace all or part of their information systems (ISs). These information service companies provide applications, such as data storage, computing processes, document sharing and even management information system services as public resources to support the business process management of their customers. However, no cloud computing service vendor can satisfy the full functional IS requirements of an enterprise. As a result, enterprises often have to simultaneously use systems distributed in different clouds and their intra enterprise ISs. Thus, this article presents a framework to integrate applications deployed in public clouds and intra ISs. A run-time platform is developed and a cross-computing environment process modelling technique is also developed to improve the feasibility of ISs under hybrid cloud computing environments.

  11. A high performance, low power computational platform for complex sensing operations in smart cities

    KAUST Repository

    Jiang, Jiming; Claudel, Christian

    2017-01-01

    This paper presents a new wireless platform designed for an integrated traffic/flash flood monitoring system. The sensor platform is built around a 32-bit ARM Cortex M4 microcontroller and a 2.4GHz 802.15.4802.15.4 ISM compliant radio module. It can be interfaced with fixed traffic sensors, or receive data from vehicle transponders. This platform is specifically designed for solar-powered, low bandwidth, high computational performance wireless sensor network applications. A self-recovering unit is designed to increase reliability and allow periodic hard resets, an essential requirement for sensor networks. A radio monitoring circuitry is proposed to monitor incoming and outgoing transmissions, simplifying software debugging. We illustrate the performance of this wireless sensor platform on complex problems arising in smart cities, such as traffic flow monitoring, machine-learning-based flash flood monitoring or Kalman-filter based vehicle trajectory estimation. All design files have been uploaded and shared in an open science framework, and can be accessed from [1]. The hardware design is under CERN Open Hardware License v1.2.

  12. A high performance, low power computational platform for complex sensing operations in smart cities

    KAUST Repository

    Jiang, Jiming

    2017-02-02

    This paper presents a new wireless platform designed for an integrated traffic/flash flood monitoring system. The sensor platform is built around a 32-bit ARM Cortex M4 microcontroller and a 2.4GHz 802.15.4802.15.4 ISM compliant radio module. It can be interfaced with fixed traffic sensors, or receive data from vehicle transponders. This platform is specifically designed for solar-powered, low bandwidth, high computational performance wireless sensor network applications. A self-recovering unit is designed to increase reliability and allow periodic hard resets, an essential requirement for sensor networks. A radio monitoring circuitry is proposed to monitor incoming and outgoing transmissions, simplifying software debugging. We illustrate the performance of this wireless sensor platform on complex problems arising in smart cities, such as traffic flow monitoring, machine-learning-based flash flood monitoring or Kalman-filter based vehicle trajectory estimation. All design files have been uploaded and shared in an open science framework, and can be accessed from [1]. The hardware design is under CERN Open Hardware License v1.2.

  13. A block-iterative nodal integral method for forced convection problems

    International Nuclear Information System (INIS)

    Decker, W.J.; Dorning, J.J.

    1992-01-01

    A new efficient iterative nodal integral method for the time-dependent two- and three-dimensional incompressible Navier-Stokes equations has been developed. Using the approach introduced by Azmy and Droning to develop nodal mehtods with high accuracy on coarse spatial grids for two-dimensional steady-state problems and extended to coarse two-dimensional space-time grids by Wilson et al. for thermal convection problems, we have developed a new iterative nodal integral method for the time-dependent Navier-Stokes equations for mechanically forced convection. A new, extremely efficient block iterative scheme is employed to invert the Jacobian within each of the Newton-Raphson iterations used to solve the final nonlinear discrete-variable equations. By taking advantage of the special structure of the Jacobian, this scheme greatly reduces memory requirements. The accuracy of the overall method is illustrated by appliying it to the time-dependent version of the classic two-dimensional driven cavity problem of computational fluid dynamics

  14. Integrating packing and distribution problems and optimization through mathematical programming

    Directory of Open Access Journals (Sweden)

    Fabio Miguel

    2016-06-01

    Full Text Available This paper analyzes the integration of two combinatorial problems that frequently arise in production and distribution systems. One is the Bin Packing Problem (BPP problem, which involves finding an ordering of some objects of different volumes to be packed into the minimal number of containers of the same or different size. An optimal solution to this NP-Hard problem can be approximated by means of meta-heuristic methods. On the other hand, we consider the Capacitated Vehicle Routing Problem with Time Windows (CVRPTW, which is a variant of the Travelling Salesman Problem (again a NP-Hard problem with extra constraints. Here we model those two problems in a single framework and use an evolutionary meta-heuristics to solve them jointly. Furthermore, we use data from a real world company as a test-bed for the method introduced here.

  15. Integrated System Design for a Large Wind Turbine Supported on a Moored Semi-Submersible Platform

    Directory of Open Access Journals (Sweden)

    Jinsong Liu

    2018-01-01

    Full Text Available Over the past few decades, wind energy has emerged as an alternative to conventional power generation that is economical, environmentally friendly and, importantly, renewable. Specifically, offshore wind energy is being considered by a number of countries to harness the stronger and more consistent wind resource compared to that over land. To meet the projected “20% energy from wind by 2030” scenario that was announced in 2006, 54 GW of added wind energy capacity need to come from offshore according to a National Renewable Energy Laboratory (NREL study. In this study, we discuss the development of a semi-submersible floating offshore platform with a catenary mooring system to support a very large 13.2-MW wind turbine with 100-m blades. An iterative design process is applied to baseline models with Froude scaling in order to achieve preliminary static stability. Structural dynamic analyses are performed to investigate the performance of the new model using a finite element method approach for the tower and a boundary integral equation (panel method for the platform. The steady-state response of the system under uniform wind and regular waves is first studied to evaluate the performance of the integrated system. Response amplitude operators (RAOs are computed in the time domain using white-noise wave excitation; this serves to highlight nonlinear, as well as dynamic characteristics of the system. Finally, selected design load cases (DLCs and the stochastic dynamic response of the system are studied to assess the global performance for sea states defined by wind fields with turbulence and long-crested irregular waves.

  16. A new operational approach for solving fractional variational problems depending on indefinite integrals

    Science.gov (United States)

    Ezz-Eldien, S. S.; Doha, E. H.; Bhrawy, A. H.; El-Kalaawy, A. A.; Machado, J. A. T.

    2018-04-01

    In this paper, we propose a new accurate and robust numerical technique to approximate the solutions of fractional variational problems (FVPs) depending on indefinite integrals with a type of fixed Riemann-Liouville fractional integral. The proposed technique is based on the shifted Chebyshev polynomials as basis functions for the fractional integral operational matrix (FIOM). Together with the Lagrange multiplier method, these problems are then reduced to a system of algebraic equations, which greatly simplifies the solution process. Numerical examples are carried out to confirm the accuracy, efficiency and applicability of the proposed algorithm

  17. On-Chip Magnetic Platform for Single-Particle Manipulation with Integrated Electrical Feedback.

    Science.gov (United States)

    Monticelli, Marco; Torti, Andrea; Cantoni, Matteo; Petti, Daniela; Albisetti, Edoardo; Manzin, Alessandra; Guerriero, Erica; Sordan, Roman; Gervasoni, Giacomo; Carminati, Marco; Ferrari, Giorgio; Sampietro, Marco; Bertacco, Riccardo

    2016-02-17

    Methods for the manipulation of single magnetic particles have become very interesting, in particular for in vitro biological studies. Most of these studies require an external microscope to provide the operator with feedback for controlling the particle motion, thus preventing the use of magnetic particles in high-throughput experiments. In this paper, a simple and compact system with integrated electrical feedback is presented, implementing in the very same device both the manipulation and detection of the transit of single particles. The proposed platform is based on zig-zag shaped magnetic nanostructures, where transverse magnetic domain walls are pinned at the corners and attract magnetic particles in suspension. By applying suitable external magnetic fields, the domain walls move to the nearest corner, thus causing the step by step displacement of the particles along the nanostructure. The very same structure is also employed for detecting the bead transit. Indeed, the presence of the magnetic particle in suspension over the domain wall affects the depinning field required for its displacement. This characteristic field can be monitored through anisotropic magnetoresistance measurements, thus implementing an integrated electrical feedback of the bead transit. In particular, the individual manipulation and detection of single 1-μm sized beads is demonstrated. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  18. Slow Integral Manifolds and Control Problems in Critical and Twice Critical Cases

    International Nuclear Information System (INIS)

    Sobolev, Vladimir

    2016-01-01

    We consider singularly perturbed differential systems in cases where the standard theory to establish a slow integral manifold existence does not work. The theory has traditionally dealt only with perturbation problems near normally hyperbolic manifold of singularities and this manifold is supposed to isolated. Applying transformations we reduce the original singularly perturbed problem to a regularized one such that the existence of slow integral manifolds can be established by means of the standard theory. We illustrate our approach by several examples. (paper)

  19. SolveDB: Integrating Optimization Problem Solvers Into SQL Databases

    DEFF Research Database (Denmark)

    Siksnys, Laurynas; Pedersen, Torben Bach

    2016-01-01

    for optimization problems, (2) an extensible infrastructure for integrating different solvers, and (3) query optimization techniques to achieve the best execution performance and/or result quality. Extensive experiments with the PostgreSQL-based implementation show that SolveDB is a versatile tool offering much...

  20. Two hierarchies of integrable lattice equations associated with a discrete matrix spectral problem

    International Nuclear Information System (INIS)

    Li Xinyue; Xu Xixiang; Zhao Qiulan

    2008-01-01

    Two hierarchies of nonlinear integrable positive and negative lattice models are derived from a discrete spectral problem. The two lattice hierarchies are proved to have discrete zero curvature representations associated with a discrete spectral problem, which also shows that the positive and negative hierarchies correspond to positive and negative power expansions of Lax operators with respect to the spectral parameter, respectively. Moreover, the integrable lattice models in the positive hierarchy are of polynomial type, and the integrable lattice models in the negative hierarchy are of rational type. Further, we construct infinite conservation laws of the positive hierarchy, then, the integrable coupling systems of the positive hierarchy are derived from enlarging Lax pair

  1. Benefits and problems in implementation for integrated medical information system

    International Nuclear Information System (INIS)

    Park, Chang Seo; Kim, Kee Deog; Park, Hyok; Jeong, Ho Gul

    2005-01-01

    Once the decision has been made to adopt an integrated medical information system (IMIS), there are a number of tissues to overcome. Users need to be aware of the impact the change will make on end users and be prepared to address issues that arise before they become problems. The purpose of this study is to investigate the benefits and unexpected problems encountered in the implementation of IMIS and to determine a useful framework for IMIS. The Yonsei University Dental Hospital is steadily constructing an IMIS. The vendor's PACS software, Piview STAR, supports transactions between workstations that are approved to integrating the health care enterprise (IHE) with security function. It is necessary to develop an excellent framework that is good for the patient, health care provider and information system vendors, in an expert, efficient, and cost-effective manner. The problems encountered with IMIS implementation were high initial investments, delay of EMR enforcement, underdevelopment of digital radiographic appliances and software and insufficient educational training for users. The clinical environments of dental IMIS is some different from the medical situation. The best way to overcome these differences is to establish a gold standard of dental IMIS integration, which estimates the cost payback. The IHE and its technical framework are good for the patient, the health care provider and all information systems vendors.

  2. Integrating Problem-Based Learning and Simulation: Effects on Student Motivation and Life Skills.

    Science.gov (United States)

    Roh, Young Sook; Kim, Sang Suk

    2015-07-01

    Previous research has suggested that a teaching strategy integrating problem-based learning and simulation may be superior to traditional lecture. The purpose of this study was to assess learner motivation and life skills before and after taking a course involving problem-based learning and simulation. The design used repeated measures with a convenience sample of 83 second-year nursing students who completed the integrated course. Data from a self-administered questionnaire measuring learner motivation and life skills were collected at pretest, post-problem-based learning, and post-simulation time points. Repeated-measures analysis of variance determined that the mean scores for total learner motivation (F=6.62, P=.003), communication (F=8.27, Plearning (F=4.45, P=.016) differed significantly between time points. Post hoc tests using the Bonferroni correction revealed that total learner motivation and total life skills significantly increased both from pretest to postsimulation and from post-problem-based learning test to postsimulation test. Subscales of learner motivation and life skills, intrinsic goal orientation, self-efficacy for learning and performance, problem-solving skills, and self-directed learning skills significantly increased both from pretest to postsimulation test and from post-problem-based learning test to post-simulation test. The results demonstrate that an integrating problem-based learning and simulation course elicits significant improvement in learner motivation and life skills. Simulation plus problem-based learning is more effective than problem-based learning alone at increasing intrinsic goal orientation, task value, self-efficacy for learning and performance, problem solving, and self-directed learning.

  3. Analyzing Cyber-Physical Threats on Robotic Platforms.

    Science.gov (United States)

    Ahmad Yousef, Khalil M; AlMajali, Anas; Ghalyon, Salah Abu; Dweik, Waleed; Mohd, Bassam J

    2018-05-21

    Robots are increasingly involved in our daily lives. Fundamental to robots are the communication link (or stream) and the applications that connect the robots to their clients or users. Such communication link and applications are usually supported through client/server network connection. This networking system is amenable of being attacked and vulnerable to the security threats. Ensuring security and privacy for robotic platforms is thus critical, as failures and attacks could have devastating consequences. In this paper, we examine several cyber-physical security threats that are unique to the robotic platforms; specifically the communication link and the applications. Threats target integrity, availability and confidential security requirements of the robotic platforms, which use MobileEyes/arnlServer client/server applications. A robot attack tool (RAT) was developed to perform specific security attacks. An impact-oriented approach was adopted to analyze the assessment results of the attacks. Tests and experiments of attacks were conducted in simulation environment and physically on the robot. The simulation environment was based on MobileSim; a software tool for simulating, debugging and experimenting on MobileRobots/ActivMedia platforms and their environments. The robot platform PeopleBot TM was used for physical experiments. The analysis and testing results show that certain attacks were successful at breaching the robot security. Integrity attacks modified commands and manipulated the robot behavior. Availability attacks were able to cause Denial-of-Service (DoS) and the robot was not responsive to MobileEyes commands. Integrity and availability attacks caused sensitive information on the robot to be hijacked. To mitigate security threats, we provide possible mitigation techniques and suggestions to raise awareness of threats on the robotic platforms, especially when the robots are involved in critical missions or applications.

  4. Analyzing Cyber-Physical Threats on Robotic Platforms

    Directory of Open Access Journals (Sweden)

    Khalil M. Ahmad Yousef

    2018-05-01

    Full Text Available Robots are increasingly involved in our daily lives. Fundamental to robots are the communication link (or stream and the applications that connect the robots to their clients or users. Such communication link and applications are usually supported through client/server network connection. This networking system is amenable of being attacked and vulnerable to the security threats. Ensuring security and privacy for robotic platforms is thus critical, as failures and attacks could have devastating consequences. In this paper, we examine several cyber-physical security threats that are unique to the robotic platforms; specifically the communication link and the applications. Threats target integrity, availability and confidential security requirements of the robotic platforms, which use MobileEyes/arnlServer client/server applications. A robot attack tool (RAT was developed to perform specific security attacks. An impact-oriented approach was adopted to analyze the assessment results of the attacks. Tests and experiments of attacks were conducted in simulation environment and physically on the robot. The simulation environment was based on MobileSim; a software tool for simulating, debugging and experimenting on MobileRobots/ActivMedia platforms and their environments. The robot platform PeopleBotTM was used for physical experiments. The analysis and testing results show that certain attacks were successful at breaching the robot security. Integrity attacks modified commands and manipulated the robot behavior. Availability attacks were able to cause Denial-of-Service (DoS and the robot was not responsive to MobileEyes commands. Integrity and availability attacks caused sensitive information on the robot to be hijacked. To mitigate security threats, we provide possible mitigation techniques and suggestions to raise awareness of threats on the robotic platforms, especially when the robots are involved in critical missions or applications.

  5. Proof-of-Concept Prototyping for Observis Platform

    OpenAIRE

    Ekimov, Victor

    2012-01-01

    Observis Oy is a start-up company first appeared in January 2011. The company is building up a measurement platform that is open and easy to connect. It helps measurement device suppliers, system and service providers, and analyzing services to found and combine each other’s products to create more value to the end customers. Observis Oy intends to develop a platform for integration with other services in order to provide management functionality in environmental field of business. Platform i...

  6. Optimal stability polynomials for numerical integration of initial value problems

    KAUST Repository

    Ketcheson, David I.

    2013-01-08

    We consider the problem of finding optimally stable polynomial approximations to the exponential for application to one-step integration of initial value ordinary and partial differential equations. The objective is to find the largest stable step size and corresponding method for a given problem when the spectrum of the initial value problem is known. The problem is expressed in terms of a general least deviation feasibility problem. Its solution is obtained by a new fast, accurate, and robust algorithm based on convex optimization techniques. Global convergence of the algorithm is proven in the case that the order of approximation is one and in the case that the spectrum encloses a starlike region. Examples demonstrate the effectiveness of the proposed algorithm even when these conditions are not satisfied.

  7. A Practical Perspective on the Design and Implementation of Enterprise Integration Solution to improve QoS using SAP NetWeaver Platform

    Directory of Open Access Journals (Sweden)

    K.Krishna Mohan

    2010-06-01

    Full Text Available Most of the enterprise operations require information from several systems within and outside the enterprise(s. The past few years have seen explosive growth in direct program to program interaction for application integration, removing manual steps yielding tremendous improvements in reliability and efficiency. This paper addresses the practical approach for the design and implementation of Enterprise Application Integration in a heterogeneous environment with SAP NetWeaver Platform (i.e. Exchange Infrastructure (XI/Process Integration (PI using a Customizable Tool named TEmplate based Functional Requirements for Integration Design (TEFRID developed by the author(s to improve the Quality of Service (QoS and reduce the development time and cost with the end-to-end scenario development.

  8. Time-Dependent Heat Conduction Problems Solved by an Integral-Equation Approach

    International Nuclear Information System (INIS)

    Oberaigner, E.R.; Leindl, M.; Antretter, T.

    2010-01-01

    Full text: A classical task of mathematical physics is the formulation and solution of a time dependent thermoelastic problem. In this work we develop an algorithm for solving the time-dependent heat conduction equation c p ρ∂ t T-kT, ii =0 in an analytical, exact fashion for a two-component domain. By the Green's function approach the formal solution of the problem is obtained. As an intermediate result an integral-equation for the temperature history at the domain interface is formulated which can be solved analytically. This method is applied to a classical engineering problem, i.e. to a special case of a Stefan-Problem. The Green's function approach in conjunction with the integral-equation method is very useful in cases were strong discontinuities or jumps occur. The initial conditions and the system parameters of the investigated problem give rise to two jumps in the temperature field. Purely numerical solutions are obtained by using the FEM (finite element method) and the FDM (finite difference method) and compared with the analytical approach. At the domain boundary the analytical solution and the FEM-solution are in good agreement, but the FDM results show a signicant smearing effect. (author)

  9. Resilient and Robust High Performance Computing Platforms for Scientific Computing Integrity

    Energy Technology Data Exchange (ETDEWEB)

    Jin, Yier [Univ. of Central Florida, Orlando, FL (United States)

    2017-07-14

    As technology advances, computer systems are subject to increasingly sophisticated cyber-attacks that compromise both their security and integrity. High performance computing platforms used in commercial and scientific applications involving sensitive, or even classified data, are frequently targeted by powerful adversaries. This situation is made worse by a lack of fundamental security solutions that both perform efficiently and are effective at preventing threats. Current security solutions fail to address the threat landscape and ensure the integrity of sensitive data. As challenges rise, both private and public sectors will require robust technologies to protect its computing infrastructure. The research outcomes from this project try to address all these challenges. For example, we present LAZARUS, a novel technique to harden kernel Address Space Layout Randomization (KASLR) against paging-based side-channel attacks. In particular, our scheme allows for fine-grained protection of the virtual memory mappings that implement the randomization. We demonstrate the effectiveness of our approach by hardening a recent Linux kernel with LAZARUS, mitigating all of the previously presented side-channel attacks on KASLR. Our extensive evaluation shows that LAZARUS incurs only 0.943% overhead for standard benchmarks, and is therefore highly practical. We also introduced HA2lloc, a hardware-assisted allocator that is capable of leveraging an extended memory management unit to detect memory errors in the heap. We also perform testing using HA2lloc in a simulation environment and find that the approach is capable of preventing common memory vulnerabilities.

  10. SIM-DSP: A DSP-Enhanced CAD Platform for Signal Integrity Macromodeling and Simulation

    Directory of Open Access Journals (Sweden)

    Chi-Un Lei

    2014-12-01

    Full Text Available Macromodeling-Simulation process for signal integrity verifications has become necessary for the high speed circuit system design. This paper aims to introduce a “VLSI Signal Integrity Macromodeling and Simulation via Digital Signal Processing Techniques” framework (known as SIM-DSP framework, which applies digital signal processing techniques to facilitate the SI verification process in the pre-layout design phase. Core identification modules and peripheral (pre-/post-processing modules have been developed and assembled to form a verification flow. In particular, a single-step discrete cosine transform truncation (DCTT module has been developed for modeling-simulation process. In DCTT, the response modeling problem is classified as a signal compression problem, wherein the system response can be represented by a truncated set of non-pole based DCT bases, and error can be analyzed through Parseval’s theorem. Practical examples are given to show the applicability of our proposed framework.

  11. Thermo-Economic Modelling and Process Integration of CO2-Mitigation Options on Oil and Gas Platforms

    DEFF Research Database (Denmark)

    Nguyen, Tuong-Van; Tock, Laurence; Breuhaus, Peter

    2014-01-01

    recovering CO2 that can be used for enhanced oil recovery. In this paper, a North Sea platform is considered as case study, and the site-scale retrofit integration of these three options is analysed, considering thermodynamic, economic and environmental performance indicators. The results illustrate......The offshore extraction of oil and gas is an energy-intensive process associated with large CO2 and CH4 emissions to the atmosphere and chemicals to the sea. The taxation of these emissions has encouraged the development of more energy-efficient and environmental-friendly solutions, of which three...

  12. Arsenic removal from contaminated groundwater by membrane-integrated hybrid plant: optimization and control using Visual Basic platform.

    Science.gov (United States)

    Chakrabortty, S; Sen, M; Pal, P

    2014-03-01

    A simulation software (ARRPA) has been developed in Microsoft Visual Basic platform for optimization and control of a novel membrane-integrated arsenic separation plant in the backdrop of absence of such software. The user-friendly, menu-driven software is based on a dynamic linearized mathematical model, developed for the hybrid treatment scheme. The model captures the chemical kinetics in the pre-treating chemical reactor and the separation and transport phenomena involved in nanofiltration. The software has been validated through extensive experimental investigations. The agreement between the outputs from computer simulation program and the experimental findings are excellent and consistent under varying operating conditions reflecting high degree of accuracy and reliability of the software. High values of the overall correlation coefficient (R (2) = 0.989) and Willmott d-index (0.989) are indicators of the capability of the software in analyzing performance of the plant. The software permits pre-analysis, manipulation of input data, helps in optimization and exhibits performance of an integrated plant visually on a graphical platform. Performance analysis of the whole system as well as the individual units is possible using the tool. The software first of its kind in its domain and in the well-known Microsoft Excel environment is likely to be very useful in successful design, optimization and operation of an advanced hybrid treatment plant for removal of arsenic from contaminated groundwater.

  13. Sparse canonical methods for biological data integration: application to a cross-platform study

    Directory of Open Access Journals (Sweden)

    Robert-Granié Christèle

    2009-01-01

    Full Text Available Abstract Background In the context of systems biology, few sparse approaches have been proposed so far to integrate several data sets. It is however an important and fundamental issue that will be widely encountered in post genomic studies, when simultaneously analyzing transcriptomics, proteomics and metabolomics data using different platforms, so as to understand the mutual interactions between the different data sets. In this high dimensional setting, variable selection is crucial to give interpretable results. We focus on a sparse Partial Least Squares approach (sPLS to handle two-block data sets, where the relationship between the two types of variables is known to be symmetric. Sparse PLS has been developed either for a regression or a canonical correlation framework and includes a built-in procedure to select variables while integrating data. To illustrate the canonical mode approach, we analyzed the NCI60 data sets, where two different platforms (cDNA and Affymetrix chips were used to study the transcriptome of sixty cancer cell lines. Results We compare the results obtained with two other sparse or related canonical correlation approaches: CCA with Elastic Net penalization (CCA-EN and Co-Inertia Analysis (CIA. The latter does not include a built-in procedure for variable selection and requires a two-step analysis. We stress the lack of statistical criteria to evaluate canonical correlation methods, which makes biological interpretation absolutely necessary to compare the different gene selections. We also propose comprehensive graphical representations of both samples and variables to facilitate the interpretation of the results. Conclusion sPLS and CCA-EN selected highly relevant genes and complementary findings from the two data sets, which enabled a detailed understanding of the molecular characteristics of several groups of cell lines. These two approaches were found to bring similar results, although they highlighted the same

  14. Global Software Development with Cloud Platforms

    Science.gov (United States)

    Yara, Pavan; Ramachandran, Ramaseshan; Balasubramanian, Gayathri; Muthuswamy, Karthik; Chandrasekar, Divya

    Offshore and outsourced distributed software development models and processes are facing challenges, previously unknown, with respect to computing capacity, bandwidth, storage, security, complexity, reliability, and business uncertainty. Clouds promise to address these challenges by adopting recent advances in virtualization, parallel and distributed systems, utility computing, and software services. In this paper, we envision a cloud-based platform that addresses some of these core problems. We outline a generic cloud architecture, its design and our first implementation results for three cloud forms - a compute cloud, a storage cloud and a cloud-based software service- in the context of global distributed software development (GSD). Our ”compute cloud” provides computational services such as continuous code integration and a compile server farm, ”storage cloud” offers storage (block or file-based) services with an on-line virtual storage service, whereas the on-line virtual labs represent a useful cloud service. We note some of the use cases for clouds in GSD, the lessons learned with our prototypes and identify challenges that must be conquered before realizing the full business benefits. We believe that in the future, software practitioners will focus more on these cloud computing platforms and see clouds as a means to supporting a ecosystem of clients, developers and other key stakeholders.

  15. VOLTTRON™: An Agent Platform for Integrating Electric Vehicles and Smart Grid

    Energy Technology Data Exchange (ETDEWEB)

    Haack, Jereme N.; Akyol, Bora A.; Tenney, Nathan D.; Carpenter, Brandon J.; Pratt, Richard M.; Carroll, Thomas E.

    2013-12-06

    The VOLTTRON™ platform provides a secure environment for the deployment of intelligent applications in the smart grid. VOLTTRON design is based on the needs of control applications running on small form factor devices, namely security and resource guarantees. Services such as resource discovery, secure agent mobility, and interacting with smart and legacy devices are provided by the platform to ease the development of control applications and accelerate their deployment. VOLTTRON platform has been demonstrated in several different domains that influenced and enhanced its capabilities. This paper will discuss the features of VOLTTRON and highlight its usage to coordinate electric vehicle charging with home energy usage

  16. Integrating Study Skills and Problem Solving into Remedial Mathematics

    Science.gov (United States)

    Cornick, Jonathan; Guy, G. Michael; Beckford, Ian

    2015-01-01

    Students at a large urban community college enrolled in seven classes of an experimental remedial algebra programme, which integrated study skills instruction and collaborative problem solving. A control group of seven classes was taught in a traditional lecture format without study skills instruction. Student performance in the course was…

  17. Learning Radiology in an Integrated Problem-Based Learning (PBL ...

    African Journals Online (AJOL)

    Background: The Faculty of Medicine (FoM) has been training health professions in Uganda since 1924. Five years ago, it decided to change the undergraduate curriculum from traditional to Problem Based Learning (PBL) and adopted the SPICES model. Radiology was integrated into the different courses throughout the 5 ...

  18. A platform to integrate climate information and rural telemedicine in Malawi

    Science.gov (United States)

    Lowe, R.; Chadza, T.; Chirombo, J.; Fonda, C.; Muyepa, A.; Nkoloma, M.; Pietrosemoli, E.; Radicella, S. M.; Tompkins, A. M.; Zennaro, M.

    2012-04-01

    It is commonly accepted that climate plays a role in the transmission of many infectious diseases, particularly those transmitted by mosquitoes such as malaria, which is one of the most important causes of mortality and morbidity in developing countries. Due to time lags involved in the climate-disease transmission system, lagged observed climate variables could provide some predictive lead for forecasting disease epidemics. This lead time could be extended by using forecasts of the climate in disease prediction models. This project aims to implement a platform for the dissemination of climate-driven disease risk forecasts, using a telemedicine approach. A pilot project has been established in Malawi, where a 162 km wireless link has been installed, spanning from Blantyre City to remote health facilities in the district of Mangochi in the Southern region, bordering Lake Malawi. This long Wi-Fi technology allows rural health facilities to upload real-time disease cases as they occur to an online health information system (DHIS2); a national medical database repository administered by the Ministry of Health. This technology provides a real-time data logging system for disease incidence monitoring and facilitates the flow of information between local and national levels. This platform allows statistical and dynamical disease prediction models to be rapidly updated with real-time climate and epidemiological information. This permits health authorities to target timely interventions ahead of an imminent increase in malaria incidence. By integrating meteorological and health information systems in a statistical-dynamical prediction model, we show that a long-distance Wi-Fi link is a practical and inexpensive means to enable the rapid analysis of real-time information in order to target disease prevention and control measures and mobilise resources at the local level.

  19. Evaluation Models for E-Learning Platform in Riyadh City Universities (RCU with Applied of Geographical Information System (GIS

    Directory of Open Access Journals (Sweden)

    Abdulaziz I. Alharrah

    2014-12-01

    Full Text Available E-learning that integrates digital knowledge content, network and information technology has become an emerging learning method. As the e-learning platform approach is becoming an important tool to allow the flexibility and quality requested by such a kind of learning process. There is a new kind of problem faced by organizations consisting in the selection of the most suitable e-learning platform. This paper proposes evaluation model for E-Learning platform in Riyadh City universities (RCU with Applied Geographic Information System (GIS. The E-Learning platform solution selection is a multiple criteria decision-making problem that needs to be addressed objectively taking into consideration the relative weights of the criteria for any organization. We formulate the quoted multi criteria problem as a decision hierarchy to be solved using GIS. AGIS-based evaluation index system and web-based evaluating platform were established. In this paper we will show the general evaluation strategy and some obtained results using our model to evaluate some existing commercial platforms.The results of evaluation model are outlined as follows: Total weights of the proposed framework in management feature is 20.25/25, in collaborative feature is 9.2/10, in adaption learning path is 6.8/10 and in interactive learning object is 5/5. The total weights of all features are 41.25/50. In this study an evaluation model was applied on Riyadh City universities like KSU, IMAMU, NAUSS, YU and FU. Then, the results were compared with each other. The total weighs of KSU was 41. While the total weights of FU, IMAMU, YU and NAUSS was 40, 37, 36 and 32, respectively. Evaluation process shows that the proposed framework satisfied the objectives with applied GIS.

  20. Integral methods of solving boundary-value problems of nonstationary heat conduction and their comparative analysis

    Science.gov (United States)

    Kot, V. A.

    2017-11-01

    The modern state of approximate integral methods used in applications, where the processes of heat conduction and heat and mass transfer are of first importance, is considered. Integral methods have found a wide utility in different fields of knowledge: problems of heat conduction with different heat-exchange conditions, simulation of thermal protection, Stefantype problems, microwave heating of a substance, problems on a boundary layer, simulation of a fluid flow in a channel, thermal explosion, laser and plasma treatment of materials, simulation of the formation and melting of ice, inverse heat problems, temperature and thermal definition of nanoparticles and nanoliquids, and others. Moreover, polynomial solutions are of interest because the determination of a temperature (concentration) field is an intermediate stage in the mathematical description of any other process. The following main methods were investigated on the basis of the error norms: the Tsoi and Postol’nik methods, the method of integral relations, the Gudman integral method of heat balance, the improved Volkov integral method, the matched integral method, the modified Hristov method, the Mayer integral method, the Kudinov method of additional boundary conditions, the Fedorov boundary method, the method of weighted temperature function, the integral method of boundary characteristics. It was established that the two last-mentioned methods are characterized by high convergence and frequently give solutions whose accuracy is not worse that the accuracy of numerical solutions.

  1. Robust integration schemes for junction-based modulators in a 200mm CMOS compatible silicon photonic platform (Conference Presentation)

    Science.gov (United States)

    Szelag, Bertrand; Abraham, Alexis; Brision, Stéphane; Gindre, Paul; Blampey, Benjamin; Myko, André; Olivier, Segolene; Kopp, Christophe

    2017-05-01

    Silicon photonic is becoming a reality for next generation communication system addressing the increasing needs of HPC (High Performance Computing) systems and datacenters. CMOS compatible photonic platforms are developed in many foundries integrating passive and active devices. The use of existing and qualified microelectronics process guarantees cost efficient and mature photonic technologies. Meanwhile, photonic devices have their own fabrication constraints, not similar to those of cmos devices, which can affect their performances. In this paper, we are addressing the integration of PN junction Mach Zehnder modulator in a 200mm CMOS compatible photonic platform. Implantation based device characteristics are impacted by many process variations among which screening layer thickness, dopant diffusion, implantation mask overlay. CMOS devices are generally quite robust with respect to these processes thanks to dedicated design rules. For photonic devices, the situation is different since, most of the time, doped areas must be carefully located within waveguides and CMOS solutions like self-alignment to the gate cannot be applied. In this work, we present different robust integration solutions for junction-based modulators. A simulation setup has been built in order to optimize of the process conditions. It consist in a Mathlab interface coupling process and device electro-optic simulators in order to run many iterations. Illustrations of modulator characteristic variations with process parameters are done using this simulation setup. Parameters under study are, for instance, X and Y direction lithography shifts, screening oxide and slab thicknesses. A robust process and design approach leading to a pn junction Mach Zehnder modulator insensitive to lithography misalignment is then proposed. Simulation results are compared with experimental datas. Indeed, various modulators have been fabricated with different process conditions and integration schemes. Extensive

  2. Demand forecasting and information platform in tourism

    Directory of Open Access Journals (Sweden)

    Li Yue

    2017-05-01

    Full Text Available Information asymmetry and the bullwhip effect have been serious problems in the tourism supply chain. Based on platform theory, this paper established a mathematical model to explore the inner mechanism of a platform’s influence on stakeholders’ ability to forecast demand in tourism. Results showed that the variance of stakeholders’ demand predictions with a platform was smaller than the variance without a platform, which meant that a platform would improve predictions of demand for stakeholders. The higher information-processing ability of the platform also had other effects on demand forecasting. Research on the inner logic of the platform’s influence on stakeholders has important theoretical and realistic value. This area is worthy of further study.

  3. Handheld Microneedle-Based Electrolyte Sensing Platform.

    Energy Technology Data Exchange (ETDEWEB)

    Miller, Philip R. [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Rivas, Rhiana [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Johnson, David [Aquila Technologies Group, Inc., Albuquerque, NM (United States); Edwards, Thayne L. [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Koskelo, Markku [Aquila Technologies Group, Inc., Albuquerque, NM (United States); Shawa, Luay [Aquila Technologies Group, Inc., Albuquerque, NM (United States); Brener, Igal [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Chavez, Victor H. [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Polsky, Ronen [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States)

    2015-11-01

    Sandia National Laboratories will provide technical assistance, within time and budget, to Requester on testing and analyzing a microneedle-based electrolyte sensing platform. Hollow microneedles will be fabricated at Sandia and integrated with a fluidic chip using plastic laminate prototyping technology available at Sandia. In connection with commercial ion selective electrodes the sensing platform will be tested for detection of electrolytes (sodium and/or potassium) within physiological relevant concent ration ranges.

  4. Optimal stability polynomials for numerical integration of initial value problems

    KAUST Repository

    Ketcheson, David I.; Ahmadia, Aron

    2013-01-01

    We consider the problem of finding optimally stable polynomial approximations to the exponential for application to one-step integration of initial value ordinary and partial differential equations. The objective is to find the largest stable step

  5. Boundary integral equation methods in eigenvalue problems of elastodynamics and thin plates

    CERN Document Server

    Kitahara, M

    1985-01-01

    The boundary integral equation (BIE) method has been used more and more in the last 20 years for solving various engineering problems. It has important advantages over other techniques for numerical treatment of a wide class of boundary value problems and is now regarded as an indispensable tool for potential problems, electromagnetism problems, heat transfer, fluid flow, elastostatics, stress concentration and fracture problems, geomechanical problems, and steady-state and transient electrodynamics.In this book, the author gives a complete, thorough and detailed survey of the method. It pro

  6. Dynamics of dump truck entrance onto the hoist platform of a mine inclined elevator

    Energy Technology Data Exchange (ETDEWEB)

    Nosyrev, B.A.; Popov, Yu.V.; Mukhutdinov, Sh.D. (Sverdlovskii Gornyi Institut (USSR))

    1989-01-01

    Analyzes the feasibility of transporting heavy-duty dump trucks along slopes on special platforms in coal surface mines. The platforms are hoisted by winches. Theoretical problems associated with hoisting a loaded platform upwards are analyzed. Problems associated with truck travel in the platform area, its exact positioning and mechanical vibrations of the platform caused by truck movement are discussed. Vibrations of the platform with a loaded truck and vibration amplitudes are analyzed. Five states of the system are evaluated. Methods for prevention of excessive vibrations by optimization of platform design and use of flexible elements are evaluated. Optimum speed of truck movement for platform entering is recommended.

  7. HPC - Platforms Penta Chart

    Energy Technology Data Exchange (ETDEWEB)

    Trujillo, Angelina Michelle [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-10-08

    Strategy, Planning, Acquiring- very large scale computing platforms come and go and planning for immensely scalable machines often precedes actual procurement by 3 years. Procurement can be another year or more. Integration- After Acquisition, machines must be integrated into the computing environments at LANL. Connection to scalable storage via large scale storage networking, assuring correct and secure operations. Management and Utilization – Ongoing operations, maintenance, and trouble shooting of the hardware and systems software at massive scale is required.

  8. SenSyF Experience on Integration of EO Services in a Generic, Cloud-Based EO Exploitation Platform

    Science.gov (United States)

    Almeida, Nuno; Catarino, Nuno; Gutierrez, Antonio; Grosso, Nuno; Andrade, Joao; Caumont, Herve; Goncalves, Pedro; Villa, Guillermo; Mangin, Antoine; Serra, Romain; Johnsen, Harald; Grydeland, Tom; Emsley, Stephen; Jauch, Eduardo; Moreno, Jose; Ruiz, Antonio

    2016-08-01

    SenSyF is a cloud-based data processing framework for EO- based services. It has been pioneer in addressing Big Data issues from the Earth Observation point of view, and is a precursor of several of the technologies and methodologies that will be deployed in ESA's Thematic Exploitation Platforms and other related systems.The SenSyF system focuses on developing fully automated data management, together with access to a processing and exploitation framework, including Earth Observation specific tools. SenSyF is both a development and validation platform for data intensive applications using Earth Observation data. With SenSyF, scientific, institutional or commercial institutions developing EO- based applications and services can take advantage of distributed computational and storage resources, tailored for applications dependent on big Earth Observation data, and without resorting to deep infrastructure and technological investments.This paper describes the integration process and the experience gathered from different EO Service providers during the project.

  9. Unraveling Platform Strategies: A Review from an Organizational Ambidexterity Perspective

    Directory of Open Access Journals (Sweden)

    Xing Wan

    2017-05-01

    Full Text Available Platform strategies, which highlight the interdependence in and evolution of business ecosystems, are increasingly relevant for sustainable business models in the digital era. So far, platform research has existed as a fragmented body of insights from different fields, but an integrated theoretical perspective can lead to a more coherent understanding of the research overall. Organizational ambidexterity emphasizes the balance between exploration and exploitation, which is particularly conducive to understanding the sustainability of a firm. Using an organizational ambidexterity perspective, the authors analyze five platform strategies: pricing, openness, integration, differentiation, and envelopment. This paper provides a systematic review of the theoretical and empirical studies in leading management, economics, and information systems journals from 2000 to 2016. The findings show that platform strategies can help platform owners achieve ambidexterity by domain, temporal, and organizational separation. Finally, this paper proposes an agenda for future research.

  10. Health-e-Child: a grid platform for european paediatrics

    International Nuclear Information System (INIS)

    Skaburskas, K; Estrella, F; Shade, J; Manset, D; Revillard, J; Rios, A; Anjum, A; Branson, A; Bloodsworth, P; Hauer, T; McClatchey, R; Rogulin, D

    2008-01-01

    The Health-e-Child (HeC) project [1], [2] is an EC Framework Programme 6 Integrated Project that aims to develop a grid-based integrated healthcare platform for paediatrics. Using this platform biomedical informaticians will integrate heterogeneous data and perform epidemiological studies across Europe. The resulting Grid enabled biomedical information platform will be supported by robust search, optimization and matching techniques for information collected in hospitals across Europe. In particular, paediatricians will be provided with decision support, knowledge discovery and disease modelling applications that will access data in hospitals in the UK, Italy and France, integrated via the Grid. For economy of scale, reusability, extensibility, and maintainability, HeC is being developed on top of an EGEE/gLite [3] based infrastructure that provides all the common data and computation management services required by the applications. This paper discusses some of the major challenges in bio-medical data integration and indicates how these will be resolved in the HeC system. HeC is presented as an example of how computer science (and, in particular Grid infrastructures) originating from high energy physics can be adapted for use by biomedical informaticians to deliver tangible real-world benefits

  11. Some open problems in random matrix theory and the theory of integrable systems

    OpenAIRE

    Deift, Percy

    2007-01-01

    We describe a list of open problems in random matrix theory and integrable systems which was presented at the conference ``Integrable Systems, Random Matrices, and Applications'' at the Courant Institute in May 2006.

  12. Photonic Integrated Circuits

    Science.gov (United States)

    Krainak, Michael; Merritt, Scott

    2016-01-01

    Integrated photonics generally is the integration of multiple lithographically defined photonic and electronic components and devices (e.g. lasers, detectors, waveguides passive structures, modulators, electronic control and optical interconnects) on a single platform with nanometer-scale feature sizes. The development of photonic integrated circuits permits size, weight, power and cost reductions for spacecraft microprocessors, optical communication, processor buses, advanced data processing, and integrated optic science instrument optical systems, subsystems and components. This is particularly critical for small spacecraft platforms. We will give an overview of some NASA applications for integrated photonics.

  13. Flexible Communication Platform for Crisis Management

    OpenAIRE

    Jiří Barta; Tomáš Ludík; Jiří Urbánek

    2013-01-01

    Topics Disaster and Emergency Management are highly debated among experts. Fast communication will help to deal with emergencies. Problem is with the network connection and data exchange. The paper suggests a solution, which allows possibilities and perspectives of new flexible communication platform to the protection of communication systems for crisis management. This platform is used for everyday communication and communication in crisis situations too.

  14. Methodological Problems on the Way to Integrative Human Neuroscience.

    Science.gov (United States)

    Kotchoubey, Boris; Tretter, Felix; Braun, Hans A; Buchheim, Thomas; Draguhn, Andreas; Fuchs, Thomas; Hasler, Felix; Hastedt, Heiner; Hinterberger, Thilo; Northoff, Georg; Rentschler, Ingo; Schleim, Stephan; Sellmaier, Stephan; Tebartz Van Elst, Ludger; Tschacher, Wolfgang

    2016-01-01

    Neuroscience is a multidisciplinary effort to understand the structures and functions of the brain and brain-mind relations. This effort results in an increasing amount of data, generated by sophisticated technologies. However, these data enhance our descriptive knowledge , rather than improve our understanding of brain functions. This is caused by methodological gaps both within and between subdisciplines constituting neuroscience, and the atomistic approach that limits the study of macro- and mesoscopic issues. Whole-brain measurement technologies do not resolve these issues, but rather aggravate them by the complexity problem. The present article is devoted to methodological and epistemic problems that obstruct the development of human neuroscience. We neither discuss ontological questions (e.g., the nature of the mind) nor review data, except when it is necessary to demonstrate a methodological issue. As regards intradisciplinary methodological problems, we concentrate on those within neurobiology (e.g., the gap between electrical and chemical approaches to neurophysiological processes) and psychology (missing theoretical concepts). As regards interdisciplinary problems, we suggest that core disciplines of neuroscience can be integrated using systemic concepts that also entail human-environment relations. We emphasize the necessity of a meta-discussion that should entail a closer cooperation with philosophy as a discipline of systematic reflection. The atomistic reduction should be complemented by the explicit consideration of the embodiedness of the brain and the embeddedness of humans. The discussion is aimed at the development of an explicit methodology of integrative human neuroscience , which will not only link different fields and levels, but also help in understanding clinical phenomena.

  15. Methodological Problems on the Way to Integrative Human Neuroscience

    Science.gov (United States)

    Kotchoubey, Boris; Tretter, Felix; Braun, Hans A.; Buchheim, Thomas; Draguhn, Andreas; Fuchs, Thomas; Hasler, Felix; Hastedt, Heiner; Hinterberger, Thilo; Northoff, Georg; Rentschler, Ingo; Schleim, Stephan; Sellmaier, Stephan; Tebartz Van Elst, Ludger; Tschacher, Wolfgang

    2016-01-01

    Neuroscience is a multidisciplinary effort to understand the structures and functions of the brain and brain-mind relations. This effort results in an increasing amount of data, generated by sophisticated technologies. However, these data enhance our descriptive knowledge, rather than improve our understanding of brain functions. This is caused by methodological gaps both within and between subdisciplines constituting neuroscience, and the atomistic approach that limits the study of macro- and mesoscopic issues. Whole-brain measurement technologies do not resolve these issues, but rather aggravate them by the complexity problem. The present article is devoted to methodological and epistemic problems that obstruct the development of human neuroscience. We neither discuss ontological questions (e.g., the nature of the mind) nor review data, except when it is necessary to demonstrate a methodological issue. As regards intradisciplinary methodological problems, we concentrate on those within neurobiology (e.g., the gap between electrical and chemical approaches to neurophysiological processes) and psychology (missing theoretical concepts). As regards interdisciplinary problems, we suggest that core disciplines of neuroscience can be integrated using systemic concepts that also entail human-environment relations. We emphasize the necessity of a meta-discussion that should entail a closer cooperation with philosophy as a discipline of systematic reflection. The atomistic reduction should be complemented by the explicit consideration of the embodiedness of the brain and the embeddedness of humans. The discussion is aimed at the development of an explicit methodology of integrative human neuroscience, which will not only link different fields and levels, but also help in understanding clinical phenomena. PMID:27965548

  16. The Mastery Matrix for Integration Praxis: The development of a rubric for integration practice in addressing weight-related public health problems.

    Science.gov (United States)

    Berge, Jerica M; Adamek, Margaret; Caspi, Caitlin; Grannon, Katherine Y; Loth, Katie A; Trofholz, Amanda; Nanney, Marilyn S

    2018-06-01

    In response to the limitations of siloed weight-related intervention approaches, scholars have called for greater integration that is intentional, strategic, and thoughtful between researchers, health care clinicians, community members, and policy makers as a way to more effectively address weight and weight-related (e.g., obesity, diabetes, cardiovascular disease, cancer) public health problems. The Mastery Matrix for Integration Praxis was developed by the Healthy Eating and Activity across the Lifespan (HEAL) team in 2017 to advance the science and praxis of integration across the domains of research, clinical practice, community, and policy to address weight-related public health problems. Integrator functions were identified and developmental stages were created to generate a rubric for measuring mastery of integration. Creating a means to systematically define and evaluate integration praxis and expertise will allow for more individuals and teams to master integration in order to work towards promoting a culture of health. Copyright © 2018 Elsevier Inc. All rights reserved.

  17. Integrating Eye Trackers with Handwriting Tablets to Discover Difficulties of Solving Geometry Problems

    Science.gov (United States)

    Lin, John J. H.; Lin, Sunny S. J.

    2018-01-01

    To deepen our understanding of those aspects of problems that cause the most difficulty for solvers, this study integrated eye-tracking with handwriting devices to investigate problem solvers' online processes while solving geometry problems. We are interested in whether the difference between successful and unsuccessful solvers can be identified…

  18. End-to-end integrated security and performance analysis on the DEGAS Choreographer platform

    DEFF Research Database (Denmark)

    Buchholtz, Mikael; Gilmore, Stephen; Haenel, Valentin

    2005-01-01

    We present a software tool platform which facilitates security and performance analysis of systems which starts and ends with UML model descriptions. A UML project is presented to the platform for analysis, formal content is extracted in the form of process calculi descriptions, analysed with the......We present a software tool platform which facilitates security and performance analysis of systems which starts and ends with UML model descriptions. A UML project is presented to the platform for analysis, formal content is extracted in the form of process calculi descriptions, analysed...

  19. Making Spatial Statistics Service Accessible On Cloud Platform

    OpenAIRE

    Mu, X.; Wu, J.; Li, T; Zhong, Y.; Gao, X.

    2014-01-01

    Web service can bring together applications running on diverse platforms, users can access and share various data, information and models more effectively and conveniently from certain web service platform. Cloud computing emerges as a paradigm of Internet computing in which dynamical, scalable and often virtualized resources are provided as services. With the rampant growth of massive data and restriction of net, traditional web services platforms have some prominent problems existi...

  20. A Survey of Open Source Products for Building a SIP Communication Platform

    Directory of Open Access Journals (Sweden)

    Pavel Segec

    2011-01-01

    Full Text Available The Session Initiation Protocol (SIP is a multimedia signalling protocol that has evolved into a widely adopted communication standard. The integration of SIP into existing IP networks has fostered IP networks becoming a convergence platform for both real-time and non-real-time multimedia communications. This converged platform integrates data, voice, video, presence, messaging, and conference services into a single network that offers new communication experiences for users. The open source community has contributed to SIP adoption through the development of open source software for both SIP clients and servers. In this paper, we provide a survey on open SIP systems that can be built using publically available software. We identify SIP features for service development and programming, services and applications of a SIP-converged platform, and the most important technologies supporting SIP functionalities. We propose an advanced converged IP communication platform that uses SIP for service delivery. The platform supports audio and video calls, along with media services such as audio conferences, voicemail, presence, and instant messaging. Using SIP Application Programming Interfaces (APIs, the platform allows the deployment of advanced integrated services. The platform is implemented with open source software. Architecture components run on standardized hardware with no need for special purpose investments.

  1. The tsunami service bus, an integration platform for heterogeneous sensor systems

    Science.gov (United States)

    Haener, R.; Waechter, J.; Kriegel, U.; Fleischer, J.; Mueller, S.

    2009-04-01

    components remain unchanged, components can be maintained and evolved independently on each other and service functionality as a whole can be reused. In GITEWS the functional integration pattern was adopted by applying the principles of an Enterprise Service Bus (ESB) as a backbone. Four services provided by the so called Tsunami Service Bus (TSB) which are essential for early warning systems are realized compliant to services specified within the Sensor Web Enablement (SWE) initiative of the Open Geospatial Consortium (OGC). 3. ARCHITECTURE The integration platform was developed to access proprietary, heterogeneous sensor data and to provide them in a uniform manner for further use. Its core, the TSB provides both a messaging-backbone and -interfaces on the basis of a Java Messaging Service (JMS). The logical architecture of GITEWS consists of four independent layers: • A resource layer where physical or virtual sensors as well as data or model storages provide relevant measurement-, event- and analysis-data: Utilizable for the TSB are any kind of data. In addition to sensors databases, model data and processing applications are adopted. SWE specifies encoding both to access and to describe these data in a comprehensive way: 1. Sensor Model Language (SensorML): Standardized description of sensors and sensor data 2. Observations and Measurements (O&M): Model and encoding of sensor measurements • A service layer to collect and conduct data from heterogeneous and proprietary resources and provide them via standardized interfaces: The TSB enables interaction with sensors via the following services: 1. Sensor Observation Service (SOS): Standardized access to sensor data 2. Sensor Planning Service (SPS): Controlling of sensors and sensor networks 3. Sensor Alert Service (SAS): Active sending of data if defined events occur 4. Web Notification Service (WNS): Conduction of asynchronous dialogues between services • An orchestration layer where atomic services are composed and

  2. The mid-IR silicon photonics sensor platform (Conference Presentation)

    Science.gov (United States)

    Kimerling, Lionel; Hu, Juejun; Agarwal, Anuradha M.

    2017-02-01

    Advances in integrated silicon photonics are enabling highly connected sensor networks that offer sensitivity, selectivity and pattern recognition. Cost, performance and the evolution path of the so-called `Internet of Things' will gate the proliferation of these networks. The wavelength spectral range of 3-8um, commonly known as the mid-IR, is critical to specificity for sensors that identify materials by detection of local vibrational modes, reflectivity and thermal emission. For ubiquitous sensing applications in this regime, the sensors must move from premium to commodity level manufacturing volumes and cost. Scaling performance/cost is critically dependent on establishing a minimum set of platform attributes for point, wearable, and physical sensing. Optical sensors are ideal for non-invasive applications. Optical sensor device physics involves evanescent or intra-cavity structures for applied to concentration, interrogation and photo-catalysis functions. The ultimate utility of a platform is dependent on sample delivery/presentation modalities; system reset, recalibration and maintenance capabilities; and sensitivity and selectivity performance. The attributes and performance of a unified Glass-on-Silicon platform has shown good prospects for heterogeneous integration on materials and devices using a low cost process flow. Integrated, single mode, silicon photonic platforms offer significant performance and cost advantages, but they require discovery and qualification of new materials and process integration schemes for the mid-IR. Waveguide integrated light sources based on rare earth dopants and Ge-pumped frequency combs have promise. Optical resonators and waveguide spirals can enhance sensitivity. PbTe materials are among the best choices for a standard, waveguide integrated photodetector. Chalcogenide glasses are capable of transmitting mid-IR signals with high transparency. Integrated sensor case studies of i) high sensitivity analyte detection in

  3. Polymer-based platform for microfluidic systems

    Science.gov (United States)

    Benett, William [Livermore, CA; Krulevitch, Peter [Pleasanton, CA; Maghribi, Mariam [Livermore, CA; Hamilton, Julie [Tracy, CA; Rose, Klint [Boston, MA; Wang, Amy W [Oakland, CA

    2009-10-13

    A method of forming a polymer-based microfluidic system platform using network building blocks selected from a set of interconnectable network building blocks, such as wire, pins, blocks, and interconnects. The selected building blocks are interconnectably assembled and fixedly positioned in precise positions in a mold cavity of a mold frame to construct a three-dimensional model construction of a microfluidic flow path network preferably having meso-scale dimensions. A hardenable liquid, such as poly (dimethylsiloxane) is then introduced into the mold cavity and hardened to form a platform structure as well as to mold the microfluidic flow path network having channels, reservoirs and ports. Pre-fabricated elbows, T's and other joints are used to interconnect various building block elements together. After hardening the liquid the building blocks are removed from the platform structure to make available the channels, cavities and ports within the platform structure. Microdevices may be embedded within the cast polymer-based platform, or bonded to the platform structure subsequent to molding, to create an integrated microfluidic system. In this manner, the new microfluidic platform is versatile and capable of quickly generating prototype systems, and could easily be adapted to a manufacturing setting.

  4. Parallel Algorithm for Adaptive Numerical Integration

    International Nuclear Information System (INIS)

    Sujatmiko, M.; Basarudin, T.

    1997-01-01

    This paper presents an automation algorithm for integration using adaptive trapezoidal method. The interval is adaptively divided where the width of sub interval are different and fit to the behavior of its function. For a function f, an integration on interval [a,b] can be obtained, with maximum tolerance ε, using estimation (f, a, b, ε). The estimated solution is valid if the error is still in a reasonable range, fulfil certain criteria. If the error is big, however, the problem is solved by dividing it into to similar and independent sub problem on to separate [a, (a+b)/2] and [(a+b)/2, b] interval, i. e. ( f, a, (a+b)/2, ε/2) and (f, (a+b)/2, b, ε/2) estimations. The problems are solved in two different kinds of processor, root processor and worker processor. Root processor function ti divide a main problem into sub problems and distribute them to worker processor. The division mechanism may go further until all of the sub problem are resolved. The solution of each sub problem is then submitted to the root processor such that the solution for the main problem can be obtained. The algorithm is implemented on C-programming-base distributed computer networking system under parallel virtual machine platform

  5. A novel integrated condition-based maintenance and stochastic flexible job shop scheduling problem

    DEFF Research Database (Denmark)

    Rahmati, Seyed Habib A.; Ahmadi, Abbas; Govindan, Kannan

    2018-01-01

    the level of the system optimization. By means of this equipment, managers can benefit from a condition-based maintenance (CBM) for monitoring and managing their system. The chief aim of the paper is to develop a stochastic maintenance problem based on CBM activities engaged with a complex applied......Integrated consideration of production planning and maintenance processes is a real world assumption. Specifically, by improving the monitoring equipment such as various sensors or product-embedded information devices in recent years, joint assessment of these processes is inevitable for enhancing...... production problem called flexible job shop scheduling problem (FJSP). This integrated problem considers two maintenance scenarios in terms of corrective maintenance (CM) and preventive maintenance (PM). The activation of scenario is done by monitoring the degradation condition of the system and comparing...

  6. Exploration of optical classroom teaching by network platform

    Science.gov (United States)

    Jiao, Zheng; Ma, Kun

    2017-08-01

    The investigation shows that the difficulties students encounter in the course of optics are mainly due to the abstraction of the content of the optical course, and the problem that the description of the physical phenomenon and process is difficult to show in the classroom teaching. We consider to integrate information technology with classroom teaching. Teachers can set up course websites and create more teaching resources, such as videos of experimental processes, design of simulated optical paths, mock demonstration of optical phenomena, and so on. Teachers can use the courseware to link the resources of the website platform, and display the related resources to the students. After class, students are also able to learn through the website, which is helpful to their study.

  7. Integrating Worked Examples into Problem Posing in a Web-Based Learning Environment

    Science.gov (United States)

    Hsiao, Ju-Yuan; Hung, Chun-Ling; Lan, Yu-Feng; Jeng, Yoau-Chau

    2013-01-01

    Most students always lack of experience and perceive difficult regarding problem posing. The study hypothesized that worked examples may have benefits for supporting students' problem posing activities. A quasi-experiment was conducted in the context of a business mathematics course for examining the effects of integrating worked examples into…

  8. Integrative Problem-Centered Therapy: Toward the Synthesis of Family and Individual Psychotherapies.

    Science.gov (United States)

    Pinsof, William M.

    1983-01-01

    Presents an overview of the Integrative Problem-Centered Therapy (IPCT) Model, and describes its core principles and premises, and basic methodological steps. The IPCT provides a technique for applying individual and family therapy and behavioral, communicational, and psychodynamic orientations to client problems. Its goal is to create efficient…

  9. THE TSUNAMI SERVICE BUS, AN INTEGRATION PLATFORM FOR HETEROGENEOUS SENSOR SYSTEMS

    Science.gov (United States)

    Fleischer, J.; Häner, R.; Herrnkind, S.; Kriegel, U.; Schwarting, H.; Wächter, J.

    2009-12-01

    The Tsunami Service Bus (TSB) is the sensor integration platform of the German Indonesian Tsunami Early Warning System (GITEWS) [1]. The primary goal of GITEWS is to deliver reliable tsunami warnings as fast as possible. This is achieved on basis of various sensor systems like seismometers, ocean instrumentation, and GPS stations, all providing fundamental data to support prediction of tsunami wave propagation by the GITEWS warning center. However, all these sensors come with their own proprietary data formats and specific behavior. Also new sensor types might be added, old sensors will be replaced. To keep GITEWS flexible the TSB was developed in order to access and control sensors in a uniform way. To meet these requirements the TSB follows the architectural blueprint of a Service Oriented Architecture (SOA). The integration platform implements dedicated services communicating via a service infrastructure. The functionality required for early warnings is provided by loosely coupled services replacing the "hard-wired" coupling at data level. Changes in the sensor specification are confined to the data level without affecting the warning center. Great emphasis was laid on following the Sensor Web Enablement (SWE) standard [2], specified by the Open Geospatial Consortium (OGC) [3]. As a result the full functionality needed in GITEWS could be achieved by implementing the four SWE services: The Sensor Observation Service for retrieving sensor measurements, the Sensor Alert Service in order to deliver sensor alerts, the Sensor Planning Service for tasking sensors, and the Web Notification Service for conduction messages to various media channels. Beyond these services the TSB also follows SWE Observation & Measurements specifications (O&M) for data encoding and Sensor Model Language (SensorML) for meta information. Moreover, accessing sensors via the TSB is not restricted to GITEWS. Multiple instances of the TSB can be composed to realize federate warning system

  10. Functional Analysis of OMICs Data and Small Molecule Compounds in an Integrated "Knowledge-Based" Platform.

    Science.gov (United States)

    Dubovenko, Alexey; Nikolsky, Yuri; Rakhmatulin, Eugene; Nikolskaya, Tatiana

    2017-01-01

    Analysis of NGS and other sequencing data, gene variants, gene expression, proteomics, and other high-throughput (OMICs) data is challenging because of its biological complexity and high level of technical and biological noise. One way to deal with both problems is to perform analysis with a high fidelity annotated knowledgebase of protein interactions, pathways, and functional ontologies. This knowledgebase has to be structured in a computer-readable format and must include software tools for managing experimental data, analysis, and reporting. Here, we present MetaCore™ and Key Pathway Advisor (KPA), an integrated platform for functional data analysis. On the content side, MetaCore and KPA encompass a comprehensive database of molecular interactions of different types, pathways, network models, and ten functional ontologies covering human, mouse, and rat genes. The analytical toolkit includes tools for gene/protein list enrichment analysis, statistical "interactome" tool for the identification of over- and under-connected proteins in the dataset, and a biological network analysis module made up of network generation algorithms and filters. The suite also features Advanced Search, an application for combinatorial search of the database content, as well as a Java-based tool called Pathway Map Creator for drawing and editing custom pathway maps. Applications of MetaCore and KPA include molecular mode of action of disease research, identification of potential biomarkers and drug targets, pathway hypothesis generation, analysis of biological effects for novel small molecule compounds and clinical applications (analysis of large cohorts of patients, and translational and personalized medicine).

  11. PROBLEMS OF INTEGRATION AT THE FORMER SOVIET UNION

    Directory of Open Access Journals (Sweden)

    Еlena А. Hudorenko

    2015-01-01

    Full Text Available The article provides analysis of historical retrospective of integrationprocesses in former Soviet Union, ways and opportunities for furtherdevelopment thereof.The authors make a study of the problems of development and functioningof Eurasian cooperation, the effectiveness of interaction with certain states,analyze the reasons of failures, emphasize the achievements results ofcooperation, point out the opportunities for integration processes betweendifferent CIS and provide practical recommendations for effectiveness thereof in former Soviet Union.

  12. An integrated in vitro imaging platform for characterizing filarial parasite behavior within a multicellular microenvironment.

    Directory of Open Access Journals (Sweden)

    Timothy Kassis

    2014-11-01

    Full Text Available Lymphatic Filariasis, a Neglected Tropical Disease, is caused by thread-like parasitic worms, including B. malayi, which migrate to the human lymphatic system following transmission. The parasites reside in collecting lymphatic vessels and lymph nodes for years, often resulting in lymphedema, elephantiasis or hydrocele. The mechanisms driving worm migration and retention within the lymphatics are currently unknown. We have developed an integrated in vitro imaging platform capable of quantifying B. malayi migration and behavior in a multicellular microenvironment relevant to the initial site of worm injection by incorporating the worm in a Polydimethylsiloxane (PDMS microchannel in the presence of human dermal lymphatic endothelial cells (LECs and human dermal fibroblasts (HDFs. The platform utilizes a motorized controllable microscope with CO2 and temperature regulation to allow for worm tracking experiments with high resolution over large length and time scales. Using post-acquisition algorithms, we quantified four parameters: 1 speed, 2 thrashing intensity, 3 percentage of time spent in a given cell region and 4 persistence ratio. We demonstrated the utility of our system by quantifying these parameters for L3 B. malayi in the presence of LECs and HDFs. Speed and thrashing increased in the presence of both cell types and were altered within minutes upon exposure to the anthelmintic drug, tetramisole. The worms displayed no targeted migration towards either cell type for the time course of this study (3 hours. When cells were not present in the chamber, worm thrashing correlated directly with worm speed. However, this correlation was lost in the presence of cells. The described platform provides the ability to further study B. malayi migration and behavior.

  13. Analyzing Cyber-Physical Threats on Robotic Platforms

    Science.gov (United States)

    2018-01-01

    Robots are increasingly involved in our daily lives. Fundamental to robots are the communication link (or stream) and the applications that connect the robots to their clients or users. Such communication link and applications are usually supported through client/server network connection. This networking system is amenable of being attacked and vulnerable to the security threats. Ensuring security and privacy for robotic platforms is thus critical, as failures and attacks could have devastating consequences. In this paper, we examine several cyber-physical security threats that are unique to the robotic platforms; specifically the communication link and the applications. Threats target integrity, availability and confidential security requirements of the robotic platforms, which use MobileEyes/arnlServer client/server applications. A robot attack tool (RAT) was developed to perform specific security attacks. An impact-oriented approach was adopted to analyze the assessment results of the attacks. Tests and experiments of attacks were conducted in simulation environment and physically on the robot. The simulation environment was based on MobileSim; a software tool for simulating, debugging and experimenting on MobileRobots/ActivMedia platforms and their environments. The robot platform PeopleBotTM was used for physical experiments. The analysis and testing results show that certain attacks were successful at breaching the robot security. Integrity attacks modified commands and manipulated the robot behavior. Availability attacks were able to cause Denial-of-Service (DoS) and the robot was not responsive to MobileEyes commands. Integrity and availability attacks caused sensitive information on the robot to be hijacked. To mitigate security threats, we provide possible mitigation techniques and suggestions to raise awareness of threats on the robotic platforms, especially when the robots are involved in critical missions or applications. PMID:29883403

  14. Advances in the development of the Mexican platform for analysis and design of nuclear reactors: AZTLAN Platform; Avances en el desarrollo de la plataforma mexicana para analisis y diseno de reactores nucleares: AZTLAN Platform

    Energy Technology Data Exchange (ETDEWEB)

    Gomez T, A. M.; Puente E, F. [ININ, Carretera Mexico-Toluca s/n, 52750 Ocoyoacac, Estado de Mexico (Mexico); Del Valle G, E. [IPN, Escuela Superior de Fisica y Matematicas, Av. IPN s/n, 07738 Ciudad de Mexico (Mexico); Francois L, J. L. [UNAM, Facultad de Ingenieria, Departamento de Sistemas Energeticos, Paseo Cuauhnahuac 8532, Col. Progreso, 62550 Jiutepec, Morelos (Mexico); Espinosa P, G., E-mail: armando.gomez@inin.gob.mx [Universidad Autonoma Metropolitana, Unidad Iztapalapa, Av. San Rafael Atlixco 186, Col. Vicentina, 09340 Ciudad de Mexico (Mexico)

    2017-09-15

    The AZTLAN platform project: development of a Mexican platform for the analysis and design of nuclear reactors, financed by the SENER-CONACYT Energy Sustain ability Fund, was approved in early 2014 and formally began at the end of that year. It is a national project led by the Instituto Nacional de Investigaciones Nucleares (ININ) and with the collaboration of Instituto Politecnico Nacional (IPN), the Universidad Autonoma Metropolitana (UAM) and Universidad Nacional Autonoma de Mexico (UNAM) as part of the development team and with the participation of the Laguna Verde Nuclear Power Plant, the National Commission of Nuclear Safety and Safeguards, the Ministry of Energy and the Karlsruhe Institute of Technology (Kit, Germany) as part of the user group. The general objective of the project is to modernize, improve and integrate the neutronic, thermo-hydraulic and thermo-mechanical codes, developed in Mexican institutions, in an integrated platform, developed and maintained by Mexican experts for the benefit of Mexican institutions. Two years into the process, important steps have been taken that have consolidated the platform. The main results of these first two years have been presented in different national and international forums. In this congress, some of the most recent results that have been implemented in the platform codes are shown in more detail. The current status of the platform from a more executive view point is summarized in this paper. (Author)

  15. Cloud Based Earth Observation Data Exploitation Platforms

    Science.gov (United States)

    Romeo, A.; Pinto, S.; Loekken, S.; Marin, A.

    2017-12-01

    In the last few years data produced daily by several private and public Earth Observation (EO) satellites reached the order of tens of Terabytes, representing for scientists and commercial application developers both a big opportunity for their exploitation and a challenge for their management. New IT technologies, such as Big Data and cloud computing, enable the creation of web-accessible data exploitation platforms, which offer to scientists and application developers the means to access and use EO data in a quick and cost effective way. RHEA Group is particularly active in this sector, supporting the European Space Agency (ESA) in the Exploitation Platforms (EP) initiative, developing technology to build multi cloud platforms for the processing and analysis of Earth Observation data, and collaborating with larger European initiatives such as the European Plate Observing System (EPOS) and the European Open Science Cloud (EOSC). An EP is a virtual workspace, providing a user community with access to (i) large volume of data, (ii) algorithm development and integration environment, (iii) processing software and services (e.g. toolboxes, visualization routines), (iv) computing resources, (v) collaboration tools (e.g. forums, wiki, etc.). When an EP is dedicated to a specific Theme, it becomes a Thematic Exploitation Platform (TEP). Currently, ESA has seven TEPs in a pre-operational phase dedicated to geo-hazards monitoring and prevention, costal zones, forestry areas, hydrology, polar regions, urban areas and food security. On the technology development side, solutions like the multi cloud EO data processing platform provides the technology to integrate ICT resources and EO data from different vendors in a single platform. In particular it offers (i) Multi-cloud data discovery, (ii) Multi-cloud data management and access and (iii) Multi-cloud application deployment. This platform has been demonstrated with the EGI Federated Cloud, Innovation Platform Testbed Poland

  16. Design and study of geosciences data share platform :platform framework, data interoperability, share approach

    Science.gov (United States)

    Lu, H.; Yi, D.

    2010-12-01

    The Deep Exploration is one of the important approaches to the Geoscience research. Since 1980s we had started it and achieved a lot of data. Researchers usually integrate both data of space exploration and deep exploration to study geological structures and represent the Earth’s subsurface, and analyze and explain on the base of integrated data. Due to the different exploration approach it results the heterogeneity of data, and therefore the data achievement is always of the import issue to make the researchers confused. The problem of data share and interaction has to be solved during the development of the SinoProbe research project. Through the research of domestic and overseas well-known exploration project and geosciences data platform, the subject explores the solution of data share and interaction. Based on SOA we present the deep exploration data share framework which comprises three level: data level is used for the solution of data store and the integration of the heterogeneous data; medial level provides the data service of geophysics, geochemistry, etc. by the means of Web service, and carry out kinds of application combination by the use of GIS middleware and Eclipse RCP; interaction level provides professional and non-professional customer the access to different accuracy data. The framework adopts GeoSciML data interaction approach. GeoSciML is a geosciences information markup language, as an application of the OpenGIS Consortium’s (OGC) Geography Markup Language (GML). It transfers heterogeneous data into one earth frame and implements inter-operation. We dissertate in this article the solution how to integrate the heterogeneous data and share the data in the project of SinoProbe.

  17. Integrated Berth Allocation-Quay Crane Assignment Problem: Reformulations, Improved Constraints and Computational Results

    DEFF Research Database (Denmark)

    Iris, Cagatay; Røpke, Stefan; Pacino, Dario

    ,74% 63,0 X 7,97% 600* 68,0 67,9 0,19% 600 8 56,1 56,1 0,00% 51,3 X 9,42% 600* 56,1 55,8 0,59% 600* 9 75,1 75,0 0,13% 74,9 X 0,33% 600* 75,1 75,0 0,15% 600* BACAP can also be formulated as Generalized Set Partitioning Problem (GSPP). The model is an extension of the BAP formulation in [2] where we add new...... problem (BAP) and the quay crane assignment problem (QCAP). Such integrated problem is known in the literature ([1]) as the Berth Allocation and Crane Assignment Problem (BACAP). The state-of-the-art [1] models this problem using two decision variables X_ij and Y_ij, representing respectively the partial...... since start-time variables S_i are integrated into objective function. Inequality (1) is based on the following two observations. First, if vessel i berths before vessel j (X_ij=1), then the start time of vessel j (Sj) should be larger than the start time of vessel i plus its minimum expected processing...

  18. Offshore Energy Mapping for Northeast Atlantic and Mediterranean: MARINA PLATFORM project

    Science.gov (United States)

    Kallos, G.; Galanis, G.; Spyrou, C.; Kalogeri, C.; Adam, A.; Athanasiadis, P.

    2012-04-01

    Deep offshore ocean energy mapping requires detailed modeling of the wind, wave, tidal and ocean circulation estimations. It requires also detailed mapping of the associated extremes. An important issue in such work is the co-generation of energy (generation of wind, wave, tides, currents) in order to design platforms on an efficient way. For example wind and wave fields exhibit significant phase differences and therefore the produced energy from both sources together requires special analysis. The other two sources namely tides and currents have different temporal scales from the previous two. Another important issue is related to the estimation of the environmental frequencies in order to avoid structural problems. These are issues studied at the framework of the FP7 project MARINA PLATFORM. The main objective of the project is to develop deep water structures that can exploit the energy from wind, wave, tidal and ocean current energy sources. In particular, a primary goal will be the establishment of a set of equitable and transparent criteria for the evaluation of multi-purpose platforms for marine renewable energy. Using these criteria, a novel system set of design and optimisation tools will be produced addressing new platform design, component engineering, risk assessment, spatial planning, platform-related grid connection concepts, all focussed on system integration and reducing costs. The University of Athens group is in charge for estimation and mapping of wind, wave, tidal and ocean current resources, estimate available energy potential, map extreme event characteristics and provide any additional environmental parameter required.

  19. Tycoon market-based system: integration with EGEE

    CERN Document Server

    Dana Perez, J M

    2007-01-01

    Tycoon is a market-based system for trading resources. The idea is to integrate Tycoon with EGEE, obtaining a dynamic Grid ready to share resources with others (Universities, research centres, etc.). Tycoon will run as a new service, deploying and destroying virtual machines (Worker Nodes and Computing Elements) on demand. Tycoon will give to EGEE a dynamic, flexible, secure and transparent platform/service to trade resources more efficiently. It could attract small and medium VOs to the EGEE project, they could take advantage of the Grid resources and obtain extra computing power while EGEE could obtain credits/money for its service. Our goal is to integrate Tycoon as a new service of EGEE, we do not have special requirements, we do not need to modify the EGEE middleware, Grid special services, etc. Standard and ‘tycoonized’ nodes (Computing Elements and Worker Nodes) must coexist in the same Grid, working without problems. Our main issue would be to ensure the security of the whole system (EGEE platform...

  20. Modeling an integrated hospital management planning problem using integer optimization approach

    Science.gov (United States)

    Sitepu, Suryati; Mawengkang, Herman; Irvan

    2017-09-01

    Hospital is a very important institution to provide health care for people. It is not surprising that nowadays the people’s demands for hospital is increasing. However, due to the rising cost of healthcare services, hospitals need to consider efficiencies in order to overcome these two problems. This paper deals with an integrated strategy of staff capacity management and bed allocation planning to tackle these problems. Mathematically, the strategy can be modeled as an integer linear programming problem. We solve the model using a direct neighborhood search approach, based on the notion of superbasic variables.

  1. Fluidics platform and method for sample preparation

    Science.gov (United States)

    Benner, Henry W.; Dzenitis, John M.

    2016-06-21

    Provided herein are fluidics platforms and related methods for performing integrated sample collection and solid-phase extraction of a target component of the sample all in one tube. The fluidics platform comprises a pump, particles for solid-phase extraction and a particle-holding means. The method comprises contacting the sample with one or more reagents in a pump, coupling a particle-holding means to the pump and expelling the waste out of the pump while the particle-holding means retains the particles inside the pump. The fluidics platform and methods herein described allow solid-phase extraction without pipetting and centrifugation.

  2. Integrals of Motion for Discrete-Time Optimal Control Problems

    OpenAIRE

    Torres, Delfim F. M.

    2003-01-01

    We obtain a discrete time analog of E. Noether's theorem in Optimal Control, asserting that integrals of motion associated to the discrete time Pontryagin Maximum Principle can be computed from the quasi-invariance properties of the discrete time Lagrangian and discrete time control system. As corollaries, results for first-order and higher-order discrete problems of the calculus of variations are obtained.

  3. Virtual health platform for medical tourism purposes.

    Science.gov (United States)

    Martinez, Debora; Ferriol, Pedro; Tous, Xisco; Cabrer, Miguel; Prats, Mercedes

    2008-01-01

    This paper introduces an overview of the Virtual Health Platform (VHP), an alternative approach to create a functional PHR system in a medical tourism environment. The proposed platform has been designed in order to be integrated with EHR infrastructures and in this way it expects to be useful and more advantageous to the patient or tourist. Use cases of the VHP and its potential benefits summarize the analysis.

  4. City and mobility: towards an integrated approach to resolve energy problems

    Directory of Open Access Journals (Sweden)

    Carmela Gargiulo

    2012-07-01

    Full Text Available The issue of integration between city, mobility and energy plays a central role in the current EU policies, aimed at achieving energy saving targets, independence from fossil fuels and enhance of the urban systems resilience, but the strategies of the single states are, however, still far from its implementation. This paper proposes a reading of the current policies and of the recent initiatives aimed at improving the energy efficiency of settlements, implemented at both Community and national level, aimed at laying the groundwork for the definition of an integrated approach between city and mobility to resolve energy problem. Therefore, the paper is divided into six parts. The first part describes the transition from the concept of sustainability to the concept of resilience and illustrates the central role played by this one in the current urban and territorial research; the second part briefly analyzes the main and more recent European directives related to city, mobility and energy, while the third part describes how the energy problem is afforded in the current programming and planning tools. The fourth and fifth parts, are intended to describe the innovative practices promoted in some European and Italian cities concerning energy efficiency aimed at the integration between urban and transport systems. The last part of the paper, finally, deals with the definition of a new systemic approach for achieving objectives of energy sustainability. This approach aims at integrating strategies and actions for strategies of mobility governance, based on the certain assumption that the core for the most part of energy problems is mainly represented in medium and large cities. 

  5. Hot air balloons fill gap in atmospheric and sensing platforms

    Science.gov (United States)

    Watson, Steven M.; Price, Russ

    Eric Edgerton was having a problem he could not solve: how to noninvasively collect in situ incinerator plume data. So he called in the Air Force and learned about its Atmospheric and Sensor Test Platform program; its platform is a manned hot air balloon. Many investigators are discovering the advantages of hot air balloons as stable, inexpensive platforms for performing in situ atmospheric measurements. Some are also using remote sensing capabilities on the balloon platforms.

  6. An integrated telemedicine platform for the assessment of affective physiological states

    Directory of Open Access Journals (Sweden)

    Ganiatsas George

    2006-08-01

    Full Text Available Abstract AUBADE is an integrated platform built for the affective assessment of individuals. The system performs evaluation of the emotional state by classifying vectors of features extracted from: facial Electromyogram, Respiration, Electrodermal Activity and Electrocardiogram. The AUBADE system consists of: (a a multisensorial wearable, (b a data acquisition and wireless communication module, (c a feature extraction module, (d a 3D facial animation module which is used for the projection of the obtained data through a generic 3D face model; whereas the end-user will be able to view the facial expression of the subject in real time, (e an intelligent emotion recognition module, and (f the AUBADE databases where the acquired signals along with the subject's animation videos are saved. The system is designed to be applied to human subjects operating under extreme stress conditions, in particular car racing drivers, and also to patients suffering from neurological and psychological disorders. AUBADE's classification accuracy into five predefined emotional classes (high stress, low stress, disappointment, euphoria and neutral face is 86.0%. The pilot system applications and components are being tested and evaluated on Maserati's car. racing drivers.

  7. Distributed software framework and continuous integration in hydroinformatics systems

    Science.gov (United States)

    Zhou, Jianzhong; Zhang, Wei; Xie, Mengfei; Lu, Chengwei; Chen, Xiao

    2017-08-01

    When encountering multiple and complicated models, multisource structured and unstructured data, complex requirements analysis, the platform design and integration of hydroinformatics systems become a challenge. To properly solve these problems, we describe a distributed software framework and it’s continuous integration process in hydroinformatics systems. This distributed framework mainly consists of server cluster for models, distributed database, GIS (Geographic Information System) servers, master node and clients. Based on it, a GIS - based decision support system for joint regulating of water quantity and water quality of group lakes in Wuhan China is established.

  8. X-CHIP: an integrated platform for high-throughput protein crystallization and on-the-chip X-ray diffraction data collection

    International Nuclear Information System (INIS)

    Kisselman, Gera; Qiu, Wei; Romanov, Vladimir; Thompson, Christine M.; Lam, Robert; Battaile, Kevin P.; Pai, Emil F.; Chirgadze, Nickolay Y.

    2011-01-01

    The X-CHIP (X-ray Crystallography High-throughput Integrated Platform) is a novel microchip that has been developed to combine multiple steps of the crystallographic pipeline from crystallization to diffraction data collection on a single device to streamline the entire process. The X-CHIP (X-ray Crystallization High-throughput Integrated Platform) is a novel microchip that has been developed to combine multiple steps of the crystallographic pipeline from crystallization to diffraction data collection on a single device to streamline the entire process. The system has been designed for crystallization condition screening, visual crystal inspection, initial X-ray screening and data collection in a high-throughput fashion. X-ray diffraction data acquisition can be performed directly on-the-chip at room temperature using an in situ approach. The capabilities of the chip eliminate the necessity for manual crystal handling and cryoprotection of crystal samples, while allowing data collection from multiple crystals in the same drop. This technology would be especially beneficial for projects with large volumes of data, such as protein-complex studies and fragment-based screening. The platform employs hydrophilic and hydrophobic concentric ring surfaces on a miniature plate transparent to visible light and X-rays to create a well defined and stable microbatch crystallization environment. The results of crystallization and data-collection experiments demonstrate that high-quality well diffracting crystals can be grown and high-resolution diffraction data sets can be collected using this technology. Furthermore, the quality of a single-wavelength anomalous dispersion data set collected with the X-CHIP at room temperature was sufficient to generate interpretable electron-density maps. This technology is highly resource-efficient owing to the use of nanolitre-scale drop volumes. It does not require any modification for most in-house and synchrotron beamline systems and offers

  9. X-CHIP: an integrated platform for high-throughput protein crystallization and on-the-chip X-ray diffraction data collection

    Energy Technology Data Exchange (ETDEWEB)

    Kisselman, Gera; Qiu, Wei; Romanov, Vladimir; Thompson, Christine M.; Lam, Robert [Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Toronto, Ontario M5G 2C4 (Canada); Battaile, Kevin P. [Argonne National Laboratory, Argonne, Illinois 60439 (United States); Pai, Emil F.; Chirgadze, Nickolay Y., E-mail: nchirgad@uhnresearch.ca [Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Toronto, Ontario M5G 2C4 (Canada); University of Toronto, Toronto, Ontario M5S 1A8 (Canada)

    2011-06-01

    The X-CHIP (X-ray Crystallography High-throughput Integrated Platform) is a novel microchip that has been developed to combine multiple steps of the crystallographic pipeline from crystallization to diffraction data collection on a single device to streamline the entire process. The X-CHIP (X-ray Crystallization High-throughput Integrated Platform) is a novel microchip that has been developed to combine multiple steps of the crystallographic pipeline from crystallization to diffraction data collection on a single device to streamline the entire process. The system has been designed for crystallization condition screening, visual crystal inspection, initial X-ray screening and data collection in a high-throughput fashion. X-ray diffraction data acquisition can be performed directly on-the-chip at room temperature using an in situ approach. The capabilities of the chip eliminate the necessity for manual crystal handling and cryoprotection of crystal samples, while allowing data collection from multiple crystals in the same drop. This technology would be especially beneficial for projects with large volumes of data, such as protein-complex studies and fragment-based screening. The platform employs hydrophilic and hydrophobic concentric ring surfaces on a miniature plate transparent to visible light and X-rays to create a well defined and stable microbatch crystallization environment. The results of crystallization and data-collection experiments demonstrate that high-quality well diffracting crystals can be grown and high-resolution diffraction data sets can be collected using this technology. Furthermore, the quality of a single-wavelength anomalous dispersion data set collected with the X-CHIP at room temperature was sufficient to generate interpretable electron-density maps. This technology is highly resource-efficient owing to the use of nanolitre-scale drop volumes. It does not require any modification for most in-house and synchrotron beamline systems and offers

  10. Launching a Two-sided Platform

    OpenAIRE

    Solheim, Magnus Tovsen; Tovsen, Ole Kristoffer Solheim

    2017-01-01

    Two-sided platforms, such as Airbnb, Uber and eBay, have all revolutionized their industries. Despite having colossal potential, they are very difficult to launch. This is due to what s referred to as network effects, which imply that the value of the platform becomes larger as more people use it. Network effects lead to a chicken-or-egg-problem , where it is difficult to convince sellers to join if there are no buyers and vice versa, in addition to the need to reach a critical mass of users...

  11. Rapid Development of Bespoke Unmanned Platforms for Atmospheric Science

    Science.gov (United States)

    Sobester, A.; Johnston, S. J.; Scanlan, J. P.; Hart, E. E.; O'Brien, N. S.

    2012-04-01

    The effective deployment of airborne atmospheric science instruments often hinges on the development cycle time of a suitable platform, one that is capable of delivering them to the desired altitude range for a specified amount of time, along a pre-determined trajectory. This could be driven by the need to respond rapidly to sudden, unexpected events (e.g., volcano eruptions, nuclear fallout, etc.) or simply to accommodate the iterative design and flight test cycle of the instrument developer. A shorter development cycle time would also afford us the ability to quickly adapt the hardware and control logic in response to unexpected results during an experimental campaign. We report on recent developments aimed at meeting this demand. As part of the Atmospheric Science Through Robotic Aircraft (ASTRA) initiative we have investigated the use of rapid prototyping technologies to this end, both on the 'airframe' of the platform itself and on the on-board systems. We show how fast multi-disciplinary design optimization techniques, coupled with computer-controlled additive manufacturing (3D printing) and laser cutting methods and electronic prototyping (using standard, modular, programmable building blocks) can lead to the delivery of a fully customized platform integrating a given instrument in a timescale of the order of ten days. Specific examples include the design and testing of a balloon-launched glider sensorcraft and a stratospheric balloon system. The 'vehicle' for the latter was built on a 3D printer using a copolymer thermoplastic material and fitted with a sacrificial protective 'cage' laser-cut from an open-cell foam. The data logging, tracking, sensor integration and communications services of the platform were constructed using the .net Gadgeteer open source hardware kit. The flight planning and eventual post-flight recovery of the system is enabled by a generic, stochastic trajectory simulation tool, also developed as part of the ASTRA initiative. This

  12. Technological Integration of Acquisitions in Digital Industries

    DEFF Research Database (Denmark)

    Henningsson, Stefan; Toppenberg, Gustav

    2015-01-01

    providers to extend the platform core and to derive network effects by consolidating platform user groups, and (b) complement providers to create monopoly positions for the complements and for innovation complementarity. To enable these acquisition benefits, acquirers face technological integration...... challenges in process and product integration. Through a case study of Network Solutions Corp. (NSC), a Fortune 500 company that has acquired more than 175 business units, we develop four propositions explaining how the benefits of platform core and complement acquisitions are differently contingent......Acquisitions have become essential tools to retain the technological edge in digital industries. This paper analyses the technological integration challenges in such acquisitions. Acquirers in digital industries are typically platform leaders in platform markets. They acquire (a) other platform...

  13. Problems of large-scale vertically-integrated aquaculture

    Energy Technology Data Exchange (ETDEWEB)

    Webber, H H; Riordan, P F

    1976-01-01

    The problems of vertically-integrated aquaculture are outlined; they are concerned with: species limitations (in the market, biological and technological); site selection, feed, manpower needs, and legal, institutional and financial requirements. The gaps in understanding of, and the constraints limiting, large-scale aquaculture are listed. Future action is recommended with respect to: types and diversity of species to be cultivated, marketing, biotechnology (seed supply, disease control, water quality and concerted effort), siting, feed, manpower, legal and institutional aids (granting of water rights, grants, tax breaks, duty-free imports, etc.), and adequate financing. The last of hard data based on experience suggests that large-scale vertically-integrated aquaculture is a high risk enterprise, and with the high capital investment required, banks and funding institutions are wary of supporting it. Investment in pilot projects is suggested to demonstrate that large-scale aquaculture can be a fully functional and successful business. Construction and operation of such pilot farms is judged to be in the interests of both the public and private sector.

  14. Applications of integral equation methods for the numerical solution of magnetostatic and eddy current problems

    Energy Technology Data Exchange (ETDEWEB)

    Trowbridge, C W

    1976-06-01

    Various integral equation methods are described. For magnetostatic problems three formulations are considered in detail, (a) the direct solution method for the magnetisation distribution in permeable materials, (b) a method based on a scalar potential, and (c) the use of an integral equation derived from Green's Theorem, i.e. the so-called Boundary Integral Method (BIM). In the case of (a) results are given for two-and three-dimensional non-linear problems with comparisons against measurement. For methods (b) and (c), which both lead to a more economical use of the computer than (a), some preliminary results are given for simple cases. For eddy current problems various methods are discussed and some results are given from a computer program based on a vector potential formulation.

  15. Applications of integral equation methods for the numerical solution of magnetostatic and eddy current problems

    International Nuclear Information System (INIS)

    Trowbridge, C.W.

    1976-06-01

    Various integral equation methods are described. For magnetostatic problems three formulations are considered in detail, (a) the direct solution method for the magnetisation distribution in permeable materials, (b) a method based on a scalar potential and (c) the use of an integral equation derived from Green's Theorem, i.e. the so-called Boundary Integral Method (BIM). In the case of (a) results are given for two-and three-dimensional non-linear problems with comparisons against measurement. For methods (b) and (c) which both lead to a more economic use of the computer than (a) some preliminary results are given for simple cases. For eddy current problems various methods are discussed and some results are given from a computer program based on a vector potential formulation. (author)

  16. Providing a Platform for Parents? Exploring the Nature of Parental Engagement with School Learning Platforms

    Science.gov (United States)

    Selwyn, N.; Banaji, S.; Hadjithoma-Garstka, C.; Clark, W.

    2011-01-01

    This paper investigates how schools are supporting parents' involvement with their children's education through the use of "Learning Platform" technologies--i.e. the integrated use of virtual learning environments, management information systems, communications, and other information and resource-sharing technologies. Based on in-depth…

  17. Integrated Rapid-Diagnostic-Test Reader Platform on a Cellphone

    Science.gov (United States)

    Mudanyali, Onur; Dimitrov, Stoyan; Sikora, Uzair; Padmanabhan, Swati; Navruz, Isa; Ozcan, Aydogan

    2012-01-01

    We demonstrate a cellphone based Rapid-Diagnostic-Test (RDT) reader platform that can work with various lateral flow immuno-chromatographic assays and similar tests to sense the presence of a target analyte in a sample. This compact and cost-effective digital RDT reader, weighing only ~65 grams, mechanically attaches to the existing camera unit of a cellphone, where various types of RDTs can be inserted to be imaged in reflection or transmission modes under light-emitting-diode (LED) based illumination. Captured raw images of these tests are then digitally processed (within less than 0.2 sec/image) through a smart application running on the cellphone for validation of the RDT as well as for automated reading of its diagnostic result. The same smart application running on the cellphone then transmits the resulting data, together with the RDT images and other related information (e.g., demographic data) to a central server, which presents the diagnostic results on a world-map through geo-tagging. This dynamic spatio-temporal map of various RDT results can then be viewed and shared using internet browsers or through the same cellphone application. We tested this platform using malaria, tuberculosis (TB) as well as HIV RDTs by installing it on both Android based smart-phones as well as an iPhone. Providing real-time spatio-temporal statistics for the prevalence of various infectious diseases, this smart RDT reader platform running on cellphones might assist health-care professionals and policy makers to track emerging epidemics worldwide and help epidemic preparedness. PMID:22596243

  18. Facilitating students' application of the integral and the area under the curve concepts in physics problems

    Science.gov (United States)

    Nguyen, Dong-Hai

    This research project investigates the difficulties students encounter when solving physics problems involving the integral and the area under the curve concepts and the strategies to facilitate students learning to solve those types of problems. The research contexts of this project are calculus-based physics courses covering mechanics and electromagnetism. In phase I of the project, individual teaching/learning interviews were conducted with 20 students in mechanics and 15 students from the same cohort in electromagnetism. The students were asked to solve problems on several topics of mechanics and electromagnetism. These problems involved calculating physical quantities (e.g. velocity, acceleration, work, electric field, electric resistance, electric current) by integrating or finding the area under the curve of functions of related quantities (e.g. position, velocity, force, charge density, resistivity, current density). Verbal hints were provided when students made an error or were unable to proceed. A total number of 140 one-hour interviews were conducted in this phase, which provided insights into students' difficulties when solving the problems involving the integral and the area under the curve concepts and the hints to help students overcome those difficulties. In phase II of the project, tutorials were created to facilitate students' learning to solve physics problems involving the integral and the area under the curve concepts. Each tutorial consisted of a set of exercises and a protocol that incorporated the helpful hints to target the difficulties that students expressed in phase I of the project. Focus group learning interviews were conducted to test the effectiveness of the tutorials in comparison with standard learning materials (i.e. textbook problems and solutions). Overall results indicated that students learning with our tutorials outperformed students learning with standard materials in applying the integral and the area under the curve

  19. Computational problems in Arctic Research

    International Nuclear Information System (INIS)

    Petrov, I

    2016-01-01

    This article is to inform about main problems in the area of Arctic shelf seismic prospecting and exploitation of the Northern Sea Route: simulation of the interaction of different ice formations (icebergs, hummocks, and drifting ice floes) with fixed ice-resistant platforms; simulation of the interaction of icebreakers and ice- class vessels with ice formations; modeling of the impact of the ice formations on the underground pipelines; neutralization of damage for fixed and mobile offshore industrial structures from ice formations; calculation of the strength of the ground pipelines; transportation of hydrocarbons by pipeline; the problem of migration of large ice formations; modeling of the formation of ice hummocks on ice-resistant stationary platform; calculation the stability of fixed platforms; calculation dynamic processes in the water and air of the Arctic with the processing of data and its use to predict the dynamics of ice conditions; simulation of the formation of large icebergs, hummocks, large ice platforms; calculation of ridging in the dynamics of sea ice; direct and inverse problems of seismic prospecting in the Arctic; direct and inverse problems of electromagnetic prospecting of the Arctic. All these problems could be solved by up-to-date numerical methods, for example, using grid-characteristic method. (paper)

  20. Sequenced Integration and the Identification of a Problem-Solving Approach through a Learning Process

    Science.gov (United States)

    Cormas, Peter C.

    2016-01-01

    Preservice teachers (N = 27) in two sections of a sequenced, methodological and process integrated mathematics/science course solved a levers problem with three similar learning processes and a problem-solving approach, and identified a problem-solving approach through one different learning process. Similar learning processes used included:…

  1. Integrable equations, addition theorems, and the Riemann-Schottky problem

    International Nuclear Information System (INIS)

    Buchstaber, Viktor M; Krichever, I M

    2006-01-01

    The classical Weierstrass theorem claims that, among the analytic functions, the only functions admitting an algebraic addition theorem are the elliptic functions and their degenerations. This survey is devoted to far-reaching generalizations of this result that are motivated by the theory of integrable systems. The authors discovered a strong form of the addition theorem for theta functions of Jacobian varieties, and this form led to new approaches to known problems in the geometry of Abelian varieties. It is shown that strong forms of addition theorems arise naturally in the theory of the so-called trilinear functional equations. Diverse aspects of the approaches suggested here are discussed, and some important open problems are formulated.

  2. Multi-platform Integrated Positioning and Attitude Determination using GNSS

    NARCIS (Netherlands)

    Buist, P.J.

    2013-01-01

    There is trend in spacecraft engineering toward distributed systems where a number of smaller spacecraft work as a larger satellite. However, in order to make the small satellites work together as a single large platform, the precise relative positions (baseline) and orientations (attitude) of the

  3. Energy Consumption Management of Virtual Cloud Computing Platform

    Science.gov (United States)

    Li, Lin

    2017-11-01

    For energy consumption management research on virtual cloud computing platforms, energy consumption management of virtual computers and cloud computing platform should be understood deeper. Only in this way can problems faced by energy consumption management be solved. In solving problems, the key to solutions points to data centers with high energy consumption, so people are in great need to use a new scientific technique. Virtualization technology and cloud computing have become powerful tools in people’s real life, work and production because they have strong strength and many advantages. Virtualization technology and cloud computing now is in a rapid developing trend. It has very high resource utilization rate. In this way, the presence of virtualization and cloud computing technologies is very necessary in the constantly developing information age. This paper has summarized, explained and further analyzed energy consumption management questions of the virtual cloud computing platform. It eventually gives people a clearer understanding of energy consumption management of virtual cloud computing platform and brings more help to various aspects of people’s live, work and son on.

  4. An Integrated Web-Based 3d Modeling and Visualization Platform to Support Sustainable Cities

    Science.gov (United States)

    Amirebrahimi, S.; Rajabifard, A.

    2012-07-01

    Sustainable Development is found as the key solution to preserve the sustainability of cities in oppose to ongoing population growth and its negative impacts. This is complex and requires a holistic and multidisciplinary decision making. Variety of stakeholders with different backgrounds also needs to be considered and involved. Numerous web-based modeling and visualization tools have been designed and developed to support this process. There have been some success stories; however, majority failed to bring a comprehensive platform to support different aspects of sustainable development. In this work, in the context of SDI and Land Administration, CSDILA Platform - a 3D visualization and modeling platform -was proposed which can be used to model and visualize different dimensions to facilitate the achievement of sustainability, in particular, in urban context. The methodology involved the design of a generic framework for development of an analytical and visualization tool over the web. CSDILA Platform was then implemented via number of technologies based on the guidelines provided by the framework. The platform has a modular structure and uses Service-Oriented Architecture (SOA). It is capable of managing spatial objects in a 4D data store and can flexibly incorporate a variety of developed models using the platform's API. Development scenarios can be modeled and tested using the analysis and modeling component in the platform and the results are visualized in seamless 3D environment. The platform was further tested using number of scenarios and showed promising results and potentials to serve a wider need. In this paper, the design process of the generic framework, the implementation of CSDILA Platform and technologies used, and also findings and future research directions will be presented and discussed.

  5. E and P integration via the OpenSpirit framework

    International Nuclear Information System (INIS)

    Jennis, S.

    1998-01-01

    The concept of inter-operability among a consortium of oil companies and E and P applications vendors was discussed. This paper describes the business problem including cost, cycle-time and efficiency and presents a solution. Benefits for applications developers will be single development environment for cross platform deployment; focus on value-added functionality instead of infrastructure; transparent access to widely-used data-stores; higher productivity and faster turnaround time to market. Application end-users will also benefit through elimination of the need to reformat due to cross platform and multi-vendor data access; utilization of Web browsers; integration with MS Office applications leveraging desk-top tools; lower purchase and integration cost of new applications. Strategic issues for application developers, and for oil companies, and competitive advantages of the E an P industry adopting OpenSpirit as the standard business object framework were also reviewed

  6. Understanding the promises and premises of online health platforms

    NARCIS (Netherlands)

    van Dijck, J.; Poell, T.

    2016-01-01

    This article investigates the claims and complexities involved in the platform-based economics of health and fitness apps. We examine a double-edged logic inscribed in these platforms, promising to offer personal solutions to medical problems while also contributing to the public good. On the one

  7. Individual activities as an integrated part of project work - an innovative approach to project oriented and problem-based learning POPBL

    DEFF Research Database (Denmark)

    Moesby, Egon; Winther, Hans Henrik; Kørnøv, Lone

    2006-01-01

    in an individual activity to subsequently be separately assessed. The results of the individually oriented project work form the platform for final work with the project as a team. The students in each team are expected to evaluate the individual solutions and select the one solution to work on in the final phases......In this paper, the authors describe and, on the basis of a recently conducted survey, evaluate a way to increase student learning through the introduction of an individual project activity to the project oriented and problem-based and team-based project work - POPBL. This can be achieved not just...... by adding an individual activity outside or parallel to the project work, but by having the individual activity embedded as an integrated part of the overall team-based project work. In what the authors have deemed the extended project model, students work individually in the solution phase of the project...

  8. A tool to guide the process of integrating health system responses to public health problems

    Directory of Open Access Journals (Sweden)

    Tilahun Nigatu Haregu

    2015-06-01

    Full Text Available An integrated model of health system responses to public health problems is considered to be the most preferable approach. Accordingly, there are several models that stipulate what an integrated architecture should look like. However, tools that can guide the overall process of integration are lacking. This tool is designed to guide the entire process of integration of health system responses to major public health problems. It is developed by taking into account the contexts of health systems of developing countries and the emergence of double-burden of chronic diseases in these settings. Chronic diseases – HIV/AIDS and NCDs – represented the evidence base for the development of the model. System level horizontal integration of health system responses were considered in the development of this tool.

  9. Beyond xMOOCs in healthcare education: study of the feasibility in integrating virtual patient systems and MOOC platforms.

    Science.gov (United States)

    Stathakarou, Natalia; Zary, Nabil; Kononowicz, Andrzej A

    2014-01-01

    Background. Massive Open Online Courses (MOOCs) are an emerging trend in online learning. However, their technology is not yet completely adjusted to the needs of healthcare education. Integration of Virtual Patients within MOOCs to increase interactivity and foster clinical reasoning skills training, has been discussed in the past, but not verified by a practical implementation. Objective. To investigate the technical feasibility of integrating MOOCs with Virtual Patients for the purpose of enabling further research into the potential pedagogical benefits of this approach. Methods. We selected OpenEdx and Open Labyrinth as representative constituents of a MOOC platform and Virtual Patient system integration. Based upon our prior experience we selected the most fundamental technical requirement to address. Grounded in the available literature we identified an e-learning standard to guide the integration. We attempted to demonstrate the feasibility of the integration by designing a "proof-of-concept" prototype. The resulting pilot implementation was subject of verification by two test cases. Results. A Single Sign-On mechanism connecting Open Labyrinth with OpenEdx and based on the IMS LTI standard was successfully implemented and verified. Conclusion. We investigated the technical perspective of integrating Virtual Patients with MOOCs. By addressing this crucial technical requirement we set a base for future research on the educational benefits of using virtual patients in MOOCs. This provides new opportunities for integrating specialized software in healthcare education at massive scale.

  10. Beyond xMOOCs in healthcare education: study of the feasibility in integrating virtual patient systems and MOOC platforms

    Directory of Open Access Journals (Sweden)

    Natalia Stathakarou

    2014-11-01

    Full Text Available Background. Massive Open Online Courses (MOOCs are an emerging trend in online learning. However, their technology is not yet completely adjusted to the needs of healthcare education. Integration of Virtual Patients within MOOCs to increase interactivity and foster clinical reasoning skills training, has been discussed in the past, but not verified by a practical implementation.Objective. To investigate the technical feasibility of integrating MOOCs with Virtual Patients for the purpose of enabling further research into the potential pedagogical benefits of this approach.Methods. We selected OpenEdx and Open Labyrinth as representative constituents of a MOOC platform and Virtual Patient system integration. Based upon our prior experience we selected the most fundamental technical requirement to address. Grounded in the available literature we identified an e-learning standard to guide the integration. We attempted to demonstrate the feasibility of the integration by designing a “proof-of-concept” prototype. The resulting pilot implementation was subject of verification by two test cases.Results. A Single Sign-On mechanism connecting Open Labyrinth with OpenEdx and based on the IMS LTI standard was successfully implemented and verified.Conclusion. We investigated the technical perspective of integrating Virtual Patients with MOOCs. By addressing this crucial technical requirement we set a base for future research on the educational benefits of using virtual patients in MOOCs. This provides new opportunities for integrating specialized software in healthcare education at massive scale.

  11. CoreFlow: A computational platform for integration, analysis and modeling of complex biological data

    DEFF Research Database (Denmark)

    Pasculescu, Adrian; Schoof, Erwin; Creixell, Pau

    2014-01-01

    between data generation, analysis and manuscript writing. CoreFlow is being released to the scientific community as an open-sourced software package complete with proteomics-specific examples, which include corrections for incomplete isotopic labeling of peptides (SILAC) or arginine-to-proline conversion......A major challenge in mass spectrometry and other large-scale applications is how to handle, integrate, and model the data that is produced. Given the speed at which technology advances and the need to keep pace with biological experiments, we designed a computational platform, CoreFlow, which...... provides programmers with a framework to manage data in real-time. It allows users to upload data into a relational database (MySQL), and to create custom scripts in high-level languages such as R, Python, or Perl for processing, correcting and modeling this data. CoreFlow organizes these scripts...

  12. Research on monitoring and management information integration technique in waste treatment and management

    International Nuclear Information System (INIS)

    Kong Jinsong; Yu Ren; Mao Wei

    2013-01-01

    The integration of the waste treatment process and the device status monitoring information and management information is a key problem required to be solved in the information integration of the waste treatment and management. The main content of the monitoring and management information integration is discussed in the paper. The data exchange techniques, which are based on the OPC, FTP and data push technology, are applied to the different monitoring system respectively, according to their development platform, to realize the integration of the waste treatment process and device status monitoring information and management information in a waste treatment center. (authors)

  13. The integrated model for solving the single-period deterministic inventory routing problem

    Science.gov (United States)

    Rahim, Mohd Kamarul Irwan Abdul; Abidin, Rahimi; Iteng, Rosman; Lamsali, Hendrik

    2016-08-01

    This paper discusses the problem of efficiently managing inventory and routing problems in a two-level supply chain system. Vendor Managed Inventory (VMI) policy is an integrating decisions between a supplier and his customers. We assumed that the demand at each customer is stationary and the warehouse is implementing a VMI. The objective of this paper is to minimize the inventory and the transportation costs of the customers for a two-level supply chain. The problem is to determine the delivery quantities, delivery times and routes to the customers for the single-period deterministic inventory routing problem (SP-DIRP) system. As a result, a linear mixed-integer program is developed for the solutions of the SP-DIRP problem.

  14. Bridging the gap: a virtual health record for integrated home care

    Directory of Open Access Journals (Sweden)

    Maria Hägglund

    2007-06-01

    Full Text Available Introduction: The coexistence of different information systems that are unable to communicate is a persistent problem in healthcare and in integrated home care in particular. Theory and methods: Physically federated integration is used for design of the underlying technical architecture to implement a mobile virtual health record for integrated home care. A user centered system development approach is followed during design and development of the system. Results: A technical platform based on a service-oriented approach where database functionality and services are separated has been developed. This guarantees flexibility with regard to changed functional demands and allows third party systems to interact with the platform in a standardized way. A physically federated integration enables point-of-care documentation, integrated presentation of information from different feeder systems, and offline access to data on handheld devices. Feeder systems deliver information in XML-files that are mapped against an ideal XML schema, published as an interface for integration with the information broker, and inserted into the mediator database. Conclusions: A seamless flow of information between both different care professionals involved in integrated home care and patients and relatives is provided through mobile information access and interaction with different feeder systems using the virtual health record.

  15. Gene ARMADA: an integrated multi-analysis platform for microarray data implemented in MATLAB.

    Science.gov (United States)

    Chatziioannou, Aristotelis; Moulos, Panagiotis; Kolisis, Fragiskos N

    2009-10-27

    The microarray data analysis realm is ever growing through the development of various tools, open source and commercial. However there is absence of predefined rational algorithmic analysis workflows or batch standardized processing to incorporate all steps, from raw data import up to the derivation of significantly differentially expressed gene lists. This absence obfuscates the analytical procedure and obstructs the massive comparative processing of genomic microarray datasets. Moreover, the solutions provided, heavily depend on the programming skills of the user, whereas in the case of GUI embedded solutions, they do not provide direct support of various raw image analysis formats or a versatile and simultaneously flexible combination of signal processing methods. We describe here Gene ARMADA (Automated Robust MicroArray Data Analysis), a MATLAB implemented platform with a Graphical User Interface. This suite integrates all steps of microarray data analysis including automated data import, noise correction and filtering, normalization, statistical selection of differentially expressed genes, clustering, classification and annotation. In its current version, Gene ARMADA fully supports 2 coloured cDNA and Affymetrix oligonucleotide arrays, plus custom arrays for which experimental details are given in tabular form (Excel spreadsheet, comma separated values, tab-delimited text formats). It also supports the analysis of already processed results through its versatile import editor. Besides being fully automated, Gene ARMADA incorporates numerous functionalities of the Statistics and Bioinformatics Toolboxes of MATLAB. In addition, it provides numerous visualization and exploration tools plus customizable export data formats for seamless integration by other analysis tools or MATLAB, for further processing. Gene ARMADA requires MATLAB 7.4 (R2007a) or higher and is also distributed as a stand-alone application with MATLAB Component Runtime. Gene ARMADA provides a

  16. Transatlantic Integration and Developed Countries Competitiveness Problems

    Directory of Open Access Journals (Sweden)

    Alexey. A. Sidorov

    2016-01-01

    Full Text Available Factors and possible consequences of transatlantic integration are elaborated in the article. An overview of the history of transatlantic cooperation is provided. The author highlights the paramount goal of Transatlantic Trade and Investment Partnership (TTIP - strengthening the positions of its parties in the world economy against the backdrop of global competition. Stalemate in Doha round of WTO trade negotiations as well as depressed state of the European economy also contributed to transatlantic integration. Validity of the EU Commission conclusion on TTIP benefits is examined. Results of TTIP econometric modelling are critically assessed. Problems of the EU-US non-tariff liberalization are analyzed. Efficiency of the EU and US labor markets is compared. Low competitiveness of the EU in comparison to the USA and underlying risks for TTIP economic growth and employment are outlined. High unemployment, difficulties of manufacturing (including high-tech industries thereof recovery, adverse general business situation in the EU are among such risks. Various modes of regulatory cooperation and possibility of their adoption in TTIP are considered. Harmonization, erga omnes mutual recognition of regulations, bilateral mutual recognition of regulations, mutual recognition of conformity testing are distinguished. Possible implications of the modes of regulatory cooperation on TTIP members competitiveness, competition with emerging economies and global standard setting are examined. Conflict of TTIP goals and motivations is revealed. The existence of economic factors of transatlantic integration as well as overestimation of TTIP benefits (primarily for the EU economy is concluded.

  17. Assessment of cisplatin-induced kidney injury using an integrated rodent platform

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Yafei [Global Safety Assessment, AstraZeneca R and D Waltham, MA 02451 (United States); Brott, David [Patient Safety, AstraZeneca R and D Wilmington, DE 19850 (United States); Luo, Wenli [Discovery Statistics, AstraZeneca R and D Waltham, MA 02451 (United States); Gangl, Eric [DMPK, AstraZeneca R and D Waltham, MA 02451 (United States); Kamendi, Harriet; Barthlow, Herbert; Lengel, David; Fikes, James; Kinter, Lewis [Global Safety Assessment, AstraZeneca R and D Waltham, MA 02451 (United States); Valentin, Jean-Pierre [Global Safety Assessment, AstraZeneca R and D Alderley Park, Macclesfield, SK10 4TG (United Kingdom); Bialecki, Russell, E-mail: russell.bialecki@astrazeneca.com [Global Safety Assessment, AstraZeneca R and D Waltham, MA 02451 (United States)

    2013-05-01

    Current diagnosis of drug-induced kidney injury (DIKI) primarily relies on detection of elevated plasma creatinine (Cr) or blood urea nitrogen (BUN) levels; however, both are indices of overall kidney function and changes are delayed with respect to onset of nephron injury. Our aim was to investigate whether early changes in new urinary DIKI biomarkers predict plasma Cr, BUN, renal hemodynamic and kidney morphological changes associated with kidney injury following a single dose of cisplatin (CDDP) using an integrated platform in rodent. Conscious surgically prepared male Han Wistar rats were given a single intraperitoneal dose of CDDP (15 mg/kg). Glomerular filtration rate (GFR), effective renal plasma flow (ERPF), urinalysis, DIKI biomarkers, CDDP pharmacokinetics, blood pressures, heart rate, body temperature and electroencephalogram (EEG) were measured in the same vehicle- or CDDP-treated animals over 72 h. Plasma chemistry (including Cr and BUN) and renal tissues were examined at study termination. Cisplatin caused progressive reductions of GFR, ERPF, heart rate and body temperature from day 1 (0–24 h). DIKI biomarkers including alpha-glutathione S-transferase (α-GST) significantly increased as early as 6 h post-dose, which preceded significant declines of GFR and ERPF (24 h), increased plasma Cr and BUN (72 h), and associated with renal acute tubular necrosis at 72 h post-dose. The present study adds to the current understanding of CDDP action by demonstrating that early increases in urinary excretion of α-GST predict DIKI risk following acute exposure to CDDP in rats, before changes in traditional DIKI markers are evident. - Highlights: ► CDDP causes direct damage to kidneys without affecting EEG or CVS function. ► α-GST and albumin detect DIKI earlier when compared with traditional indices. ► Integrated “cardiovascular-EEG-renal” model to better understand DIKI mechanisms ► Promotes 3R's principles in drug discovery and development.

  18. Assessment of cisplatin-induced kidney injury using an integrated rodent platform

    International Nuclear Information System (INIS)

    Chen, Yafei; Brott, David; Luo, Wenli; Gangl, Eric; Kamendi, Harriet; Barthlow, Herbert; Lengel, David; Fikes, James; Kinter, Lewis; Valentin, Jean-Pierre; Bialecki, Russell

    2013-01-01

    Current diagnosis of drug-induced kidney injury (DIKI) primarily relies on detection of elevated plasma creatinine (Cr) or blood urea nitrogen (BUN) levels; however, both are indices of overall kidney function and changes are delayed with respect to onset of nephron injury. Our aim was to investigate whether early changes in new urinary DIKI biomarkers predict plasma Cr, BUN, renal hemodynamic and kidney morphological changes associated with kidney injury following a single dose of cisplatin (CDDP) using an integrated platform in rodent. Conscious surgically prepared male Han Wistar rats were given a single intraperitoneal dose of CDDP (15 mg/kg). Glomerular filtration rate (GFR), effective renal plasma flow (ERPF), urinalysis, DIKI biomarkers, CDDP pharmacokinetics, blood pressures, heart rate, body temperature and electroencephalogram (EEG) were measured in the same vehicle- or CDDP-treated animals over 72 h. Plasma chemistry (including Cr and BUN) and renal tissues were examined at study termination. Cisplatin caused progressive reductions of GFR, ERPF, heart rate and body temperature from day 1 (0–24 h). DIKI biomarkers including alpha-glutathione S-transferase (α-GST) significantly increased as early as 6 h post-dose, which preceded significant declines of GFR and ERPF (24 h), increased plasma Cr and BUN (72 h), and associated with renal acute tubular necrosis at 72 h post-dose. The present study adds to the current understanding of CDDP action by demonstrating that early increases in urinary excretion of α-GST predict DIKI risk following acute exposure to CDDP in rats, before changes in traditional DIKI markers are evident. - Highlights: ► CDDP causes direct damage to kidneys without affecting EEG or CVS function. ► α-GST and albumin detect DIKI earlier when compared with traditional indices. ► Integrated “cardiovascular-EEG-renal” model to better understand DIKI mechanisms ► Promotes 3R's principles in drug discovery and development

  19. Singular integral equations boundary problems of function theory and their application to mathematical physics

    CERN Document Server

    Muskhelishvili, N I

    2011-01-01

    Singular integral equations play important roles in physics and theoretical mechanics, particularly in the areas of elasticity, aerodynamics, and unsteady aerofoil theory. They are highly effective in solving boundary problems occurring in the theory of functions of a complex variable, potential theory, the theory of elasticity, and the theory of fluid mechanics.This high-level treatment by a noted mathematician considers one-dimensional singular integral equations involving Cauchy principal values. Its coverage includes such topics as the Hölder condition, Hilbert and Riemann-Hilbert problem

  20. A difference quotient-numerical integration method for solving radiative transfer problems

    International Nuclear Information System (INIS)

    Ding Peizhu

    1992-01-01

    A difference quotient-numerical integration method is adopted to solve radiative transfer problems in an anisotropic scattering slab medium. By using the method, the radiative transfer problem is separated into a system of linear algebraic equations and the coefficient matrix of the system is a band matrix, so the method is very simple to evaluate on computer and to deduce formulae and easy to master for experimentalists. An example is evaluated and it is shown that the method is precise

  1. Information Management Platform for Data Analytics and Aggregation (IMPALA) System Design Document

    Science.gov (United States)

    Carnell, Andrew; Akinyelu, Akinyele

    2016-01-01

    The System Design document tracks the design activities that are performed to guide the integration, installation, verification, and acceptance testing of the IMPALA Platform. The inputs to the design document are derived from the activities recorded in Tasks 1 through 6 of the Statement of Work (SOW), with the proposed technical solution being the completion of Phase 1-A. With the documentation of the architecture of the IMPALA Platform and the installation steps taken, the SDD will be a living document, capturing the details about capability enhancements and system improvements to the IMPALA Platform to provide users in development of accurate and precise analytical models. The IMPALA Platform infrastructure team, data architecture team, system integration team, security management team, project manager, NASA data scientists and users are the intended audience of this document. The IMPALA Platform is an assembly of commercial-off-the-shelf (COTS) products installed on an Apache-Hadoop platform. User interface details for the COTS products will be sourced from the COTS tools vendor documentation. The SDD is a focused explanation of the inputs, design steps, and projected outcomes of every design activity for the IMPALA Platform through installation and validation.

  2. MathWorks Simulink and C++ integration with the new VLT PLC-based standard development platform for instrument control systems

    Science.gov (United States)

    Kiekebusch, Mario J.; Di Lieto, Nicola; Sandrock, Stefan; Popovic, Dan; Chiozzi, Gianluca

    2014-07-01

    ESO is in the process of implementing a new development platform, based on PLCs, for upcoming VLT control systems (new instruments and refurbishing of existing systems to manage obsolescence issues). In this context, we have evaluated the integration and reuse of existing C++ libraries and Simulink models into the real-time environment of BECKHOFF Embedded PCs using the capabilities of the latest version of TwinCAT software and MathWorks Embedded Coder. While doing so the aim was to minimize the impact of the new platform by adopting fully tested solutions implemented in C++. This allows us to reuse the in house expertise, as well as extending the normal capabilities of the traditional PLC programming environments. We present the progress of this work and its application in two concrete cases: 1) field rotation compensation for instrument tracking devices like derotators, 2) the ESO standard axis controller (ESTAC), a generic model-based controller implemented in Simulink and used for the control of telescope main axes.

  3. A Supply Chain Design Problem Integrated Facility Unavailabilities Management

    Directory of Open Access Journals (Sweden)

    Fouad Maliki

    2016-08-01

    Full Text Available A supply chain is a set of facilities connected together in order to provide products to customers. The supply chain is subject to random failures caused by different factors which cause the unavailability of some sites. Given the current economic context, the management of these unavailabilities is becoming a strategic choice to ensure the desired reliability and availability levels of the different supply chain facilities. In this work, we treat two problems related to the field of supply chain, namely the design and unavailabilities management of logistics facilities. Specifically, we consider a stochastic distribution network with consideration of suppliers' selection, distribution centres location (DCs decisions and DCs’ unavailabilities management. Two resolution approaches are proposed. The first approach called non-integrated consists on define the optimal supply chain structure using an optimization approach based on genetic algorithms (GA, then to simulate the supply chain performance with the presence of DCs failures. The second approach called integrated approach is to consider the design of the supply chain problem and unavailabilities management of DCs in the same model. Note that, we replace each unavailable DC by performing a reallocation using GA in the two approaches. The obtained results of the two approaches are detailed and compared showing their effectiveness.

  4. Performance Tuning of Fock Matrix and Two-Electron Integral Calculations for NWChem on Leading HPC Platforms

    Energy Technology Data Exchange (ETDEWEB)

    Shan, Hongzhan; Austin, Brian M.; De Jong, Wibe A.; Oliker, Leonid; Wright, Nicholas J.; Apra, Edoardo

    2014-10-01

    Attaining performance in the evaluation of two-electron repulsion integrals and constructing the Fock matrix is of considerable importance to the computational chemistry community. Due to its numerical complexity improving the performance behavior across a variety of leading supercomputing platforms is an increasing challenge due to the significant diversity in high-performance computing architectures. In this paper, we present our successful tuning methodology for these important numerical methods on the Cray XE6, the Cray XC30, the IBM BG/Q, as well as the Intel Xeon Phi. Our optimization schemes leverage key architectural features including vectorization and simultaneous multithreading, and results in speedups of up to 2.5x compared with the original implementation.

  5. Interoperability of remote handling control system software modules at Divertor Test Platform 2 using middleware

    International Nuclear Information System (INIS)

    Tuominen, Janne; Rasi, Teemu; Mattila, Jouni; Siuko, Mikko; Esque, Salvador; Hamilton, David

    2013-01-01

    Highlights: ► The prototype DTP2 remote handling control system is a heterogeneous collection of subsystems, each realizing a functional area of responsibility. ► Middleware provides well-known, reusable solutions to problems, such as heterogeneity, interoperability, security and dependability. ► A middleware solution was selected and integrated with the DTP2 RH control system. The middleware was successfully used to integrate all relevant subsystems and functionality was demonstrated. -- Abstract: This paper focuses on the inter-subsystem communication channels in a prototype distributed remote handling control system at Divertor Test Platform 2 (DTP2). The subsystems are responsible for specific tasks and, over the years, their development has been carried out using various platforms and programming languages. The communication channels between subsystems have different priorities, e.g. very high messaging rate and deterministic timing or high reliability in terms of individual messages. Generally, a control system's communication infrastructure should provide interoperability, scalability, performance and maintainability. An attractive approach to accomplish this is to use a standardized and proven middleware implementation. The selection of a middleware can have a major cost impact in future integration efforts. In this paper we present development done at DTP2 using the Object Management Group's (OMG) standard specification for Data Distribution Service (DDS) for ensuring communications interoperability. DDS has gained a stable foothold especially in the military field. It lacks a centralized broker, thereby avoiding a single-point-of-failure. It also includes an extensive set of Quality of Service (QoS) policies. The standard defines a platform- and programming language independent model and an interoperability wire protocol that enables DDS vendor interoperability, allowing software developers to avoid vendor lock-in situations

  6. Integrated Design and Implementation of Embedded Control Systems with Scilab.

    Science.gov (United States)

    Ma, Longhua; Xia, Feng; Peng, Zhe

    2008-09-05

    Embedded systems are playing an increasingly important role in control engineering. Despite their popularity, embedded systems are generally subject to resource constraints and it is therefore difficult to build complex control systems on embedded platforms. Traditionally, the design and implementation of control systems are often separated, which causes the development of embedded control systems to be highly timeconsuming and costly. To address these problems, this paper presents a low-cost, reusable, reconfigurable platform that enables integrated design and implementation of embedded control systems. To minimize the cost, free and open source software packages such as Linux and Scilab are used. Scilab is ported to the embedded ARM-Linux system. The drivers for interfacing Scilab with several communication protocols including serial, Ethernet, and Modbus are developed. Experiments are conducted to test the developed embedded platform. The use of Scilab enables implementation of complex control algorithms on embedded platforms. With the developed platform, it is possible to perform all phases of the development cycle of embedded control systems in a unified environment, thus facilitating the reduction of development time and cost.

  7. Integrated Design and Implementation of Embedded Control Systems with Scilab

    Directory of Open Access Journals (Sweden)

    Zhe Peng

    2008-09-01

    Full Text Available Embedded systems are playing an increasingly important role in control engineering. Despite their popularity, embedded systems are generally subject to resource constraints and it is therefore difficult to build complex control systems on embedded platforms. Traditionally, the design and implementation of control systems are often separated, which causes the development of embedded control systems to be highly timeconsuming and costly. To address these problems, this paper presents a low-cost, reusable, reconfigurable platform that enables integrated design and implementation of embedded control systems. To minimize the cost, free and open source software packages such as Linux and Scilab are used. Scilab is ported to the embedded ARM-Linux system. The drivers for interfacing Scilab with several communication protocols including serial, Ethernet, and Modbus are developed. Experiments are conducted to test the developed embedded platform. The use of Scilab enables implementation of complex control algorithms on embedded platforms. With the developed platform, it is possible to perform all phases of the development cycle of embedded control systems in a unified environment, thus facilitating the reduction of development time and cost.

  8. Deliverable 3.3.1 - Assessment Methodology on ISISEMD platform

    DEFF Research Database (Denmark)

    Peterson, Carrie Beth

    2009-01-01

    The overall goal of the ISISEMD project is to offer innovative ICT services to improve the quality of life of elderly persons with cognitive problems or mild dementia and their informal and formal caregivers who provide every day care for them. This will be done via the ISISEMD platform – a platf......The overall goal of the ISISEMD project is to offer innovative ICT services to improve the quality of life of elderly persons with cognitive problems or mild dementia and their informal and formal caregivers who provide every day care for them. This will be done via the ISISEMD platform...... by the project partners. This document is devoted to describing the assessment methodology for the ISISEMD platform in terms of key aspects of the assessment, indicators for evaluation, expected benefits, etc....

  9. Future of Hydroinformatics: Towards Open, Integrated and Interactive Online Platforms

    Science.gov (United States)

    Demir, I.; Krajewski, W. F.

    2012-12-01

    Hydroinformatics is a domain of science and technology dealing with the management of information in the field of hydrology (IWA, 2011). There is the need for innovative solutions to the challenges towards open information, integration, and communication in the Internet. This presentation provides an overview of the trends and challenges in the future of hydroinformatics, and demonstrates an information system, Iowa Flood Information System (IFIS), developed within the light of these challenges. The IFIS is a web-based platform developed by the Iowa Flood Center (IFC) to provide access to flood inundation maps, real-time flood conditions, flood forecasts both short-term and seasonal, flood-related data, information and interactive visualizations for communities in Iowa. The key element of the system's architecture is the notion of community. Locations of the communities, those near streams and rivers, define basin boundaries. The IFIS provides community-centric watershed and river characteristics, weather (rainfall) conditions, and streamflow data and visualization tools. Interactive interfaces allow access to inundation maps for different stage and return period values, and flooding scenarios with contributions from multiple rivers. Real-time and historical data of water levels, gauge heights, and rainfall conditions are available in the IFIS by streaming data from automated IFC bridge sensors, USGS stream gauges, NEXRAD radars, and NWS forecasts. 2D and 3D interactive visualizations in the IFIS make the data more understandable to general public. Users are able to filter data sources for their communities and selected rivers. The data and information on IFIS is also accessible through web services and mobile applications. The IFIS is optimized for various browsers and screen sizes to provide access through multiple platforms including tablets and mobile devices. The IFIS includes a rainfall-runoff forecast model to provide a five-day flood risk estimate for more

  10. Development of mobile platform integrated with existing electronic medical records.

    Science.gov (United States)

    Kim, YoungAh; Kim, Sung Soo; Kang, Simon; Kim, Kyungduk; Kim, Jun

    2014-07-01

    This paper describes a mobile Electronic Medical Record (EMR) platform designed to manage and utilize the existing EMR and mobile application with optimized resources. We structured the mEMR to reuse services of retrieval and storage in mobile app environments that have already proven to have no problem working with EMRs. A new mobile architecture-based mobile solution was developed in four steps: the construction of a server and its architecture; screen layout and storyboard making; screen user interface design and development; and a pilot test and step-by-step deployment. This mobile architecture consists of two parts, the server-side area and the client-side area. In the server-side area, it performs the roles of service management for EMR and documents and for information exchange. Furthermore, it performs menu allocation depending on user permission and automatic clinical document architecture document conversion. Currently, Severance Hospital operates an iOS-compatible mobile solution based on this mobile architecture and provides stable service without additional resources, dealing with dynamic changes of EMR templates. The proposed mobile solution should go hand in hand with the existing EMR system, and it can be a cost-effective solution if a quality EMR system is operated steadily with this solution. Thus, we expect this example to be shared with hospitals that currently plan to deploy mobile solutions.

  11. Microfluidic Lab-on-a-Chip Platforms: Requirements, Characteristics and Applications

    Science.gov (United States)

    Mark, D.; Haeberle, S.; Roth, G.; von Stetten, F.; Zengerle, R.

    This review summarizes recent developments in microfluidic platform approaches. In contrast to isolated application-specific solutions, a microfluidic platform provides a set of fluidic unit operations, which are designed for easy combination within a well-defined fabrication technology. This allows the implementation of different application-specific (bio-) chemical processes, automated by microfluidic process integration [1]. A brief introduction into technical advances, major market segments and promising applications is followed by a detailed characterization of different microfluidic platforms, comprising a short definition, the functional principle, microfluidic unit operations, application examples as well as strengths and limitations. The microfluidic platforms in focus are lateral flow tests, linear actuated devices, pressure driven laminar flow, microfluidic large scale integration, segmented flow microfluidics, centrifugal microfluidics, electro-kinetics, electrowetting, surface acoustic waves, and systems for massively parallel analysis. The review concludes with the attempt to provide a selection scheme for microfluidic platforms which is based on their characteristics according to key requirements of different applications and market segments. Applied selection criteria comprise portability, costs of instrument and disposable, sample throughput, number of parameters per sample, reagent consumption, precision, diversity of microfluidic unit operations and the flexibility in programming different liquid handling protocols.

  12. MDWeb and MDMoby: an integrated web-based platform for molecular dynamics simulations.

    Science.gov (United States)

    Hospital, Adam; Andrio, Pau; Fenollosa, Carles; Cicin-Sain, Damjan; Orozco, Modesto; Gelpí, Josep Lluís

    2012-05-01

    MDWeb and MDMoby constitute a web-based platform to help access to molecular dynamics (MD) in the standard and high-throughput regime. The platform provides tools to prepare systems from PDB structures mimicking the procedures followed by human experts. It provides inputs and can send simulations for three of the most popular MD packages (Amber, NAMD and Gromacs). Tools for analysis of trajectories, either provided by the user or retrieved from our MoDEL database (http://mmb.pcb.ub.es/MoDEL) are also incorporated. The platform has two ways of access, a set of web-services based on the BioMoby framework (MDMoby), programmatically accessible and a web portal (MDWeb). http://mmb.irbbarcelona.org/MDWeb; additional information and methodology details can be found at the web site ( http://mmb.irbbarcelona.org/MDWeb/help.php)

  13. Integral equations of the first kind, inverse problems and regularization: a crash course

    International Nuclear Information System (INIS)

    Groetsch, C W

    2007-01-01

    This paper is an expository survey of the basic theory of regularization for Fredholm integral equations of the first kind and related background material on inverse problems. We begin with an historical introduction to the field of integral equations of the first kind, with special emphasis on model inverse problems that lead to such equations. The basic theory of linear Fredholm equations of the first kind, paying particular attention to E. Schmidt's singular function analysis, Picard's existence criterion, and the Moore-Penrose theory of generalized inverses is outlined. The fundamentals of the theory of Tikhonov regularization are then treated and a collection of exercises and a bibliography are provided

  14. Cloud Service Platform: Hospital Information eXchange(HIX)

    OpenAIRE

    Fang Zhiyuan; Wei Li

    2013-01-01

    Health Information eXchange (HIX) is a part of Happiness Cloud Service Platform of Happiness Guangdong in Guangdong Province of China based on innovation of cloud-based business model. This article illustrates the hospital health care business services system based on cloud computing. major business functions of HIX includes integrated mobile medical information services, and mobile health information services. Key cloud service platform capabilities include appointment of HIX registration, d...

  15. Sharing Health Big Data for Research - A Design by Use Cases: The INSHARE Platform Approach.

    Science.gov (United States)

    Bouzillé, Guillaume; Westerlynck, Richard; Defossez, Gautier; Bouslimi, Dalel; Bayat, Sahar; Riou, Christine; Busnel, Yann; Le Guillou, Clara; Cauvin, Jean-Michel; Jacquelinet, Christian; Pladys, Patrick; Oger, Emmanuel; Stindel, Eric; Ingrand, Pierre; Coatrieux, Gouenou; Cuggia, Marc

    2017-01-01

    Sharing and exploiting Health Big Data (HBD) allow tackling challenges: data protection/governance taking into account legal, ethical, and deontological aspects enables trust, transparent and win-win relationship between researchers, citizens, and data providers. Lack of interoperability: compartmentalized and syntactically/semantica heterogeneous data. INSHARE project using experimental proof of concept explores how recent technologies overcome such issues. Using 6 data providers, platform is designed via 3 steps to: (1) analyze use cases, needs, and requirements; (2) define data sharing governance, secure access to platform; and (3) define platform specifications. Three use cases - from 5 studies and 11 data sources - were analyzed for platform design. Governance derived from SCANNER model was adapted to data sharing. Platform architecture integrates: data repository and hosting, semantic integration services, data processing, aggregate computing, data quality and integrity monitoring, Id linking, multisource query builder, visualization and data export services, data governance, study management service and security including data watermarking.

  16. A Social Environmental Sensor Network Integrated within a Web GIS Platform

    Directory of Open Access Journals (Sweden)

    Yorghos Voutos

    2017-11-01

    Full Text Available We live in an era where typical measures towards the mitigation of environmental degradation follow the identification and recording of natural parameters closely associated with it. In addition, current scientific knowledge on the one hand may be applied to minimize the environmental impact of anthropogenic activities, whereas informatics on the other, playing a key role in this ecosystem, do offer new ways of implementing complex scientific processes regarding the collection, aggregation and analysis of data concerning environmental parameters. Furthermore, another related aspect to consider is the fact that almost all relevant data recordings are influenced by their given spatial characteristics. Taking all aforementioned inputs into account, managing such a great amount of complex and remote data requires specific digital structures; these structures are typically deployed over the Web on an attempt to capitalize existing open software platforms and modern developments of hardware technology. In this paper we present an effort to provide a technical solution based on sensing devices that are based on the well-known Arduino platform and operate continuously for gathering and transmitting of environmental state information. Controls, user interface and extensions of the proposed project rely on the Android mobile device platform (both from the software and hardware side. Finally, a crucial novel aspect of our work is the fact that all herein gathered data carry spatial information, which is rather fundamental for the successful correlation between pollutants and their place of origin. The latter is implemented by an interactive Web GIS platform operating oversight in situ and on a timeline basis.

  17. A priority-based heuristic algorithm (PBHA for optimizing integrated process planning and scheduling problem

    Directory of Open Access Journals (Sweden)

    Muhammad Farhan Ausaf

    2015-12-01

    Full Text Available Process planning and scheduling are two important components of a manufacturing setup. It is important to integrate them to achieve better global optimality and improved system performance. To find optimal solutions for integrated process planning and scheduling (IPPS problem, numerous algorithm-based approaches exist. Most of these approaches try to use existing meta-heuristic algorithms for solving the IPPS problem. Although these approaches have been shown to be effective in optimizing the IPPS problem, there is still room for improvement in terms of quality of solution and algorithm efficiency, especially for more complicated problems. Dispatching rules have been successfully utilized for solving complicated scheduling problems, but haven’t been considered extensively for the IPPS problem. This approach incorporates dispatching rules with the concept of prioritizing jobs, in an algorithm called priority-based heuristic algorithm (PBHA. PBHA tries to establish job and machine priority for selecting operations. Priority assignment and a set of dispatching rules are simultaneously used to generate both the process plans and schedules for all jobs and machines. The algorithm was tested for a series of benchmark problems. The proposed algorithm was able to achieve superior results for most complex problems presented in recent literature while utilizing lesser computational resources.

  18. Long Read Alignment with Parallel MapReduce Cloud Platform

    Directory of Open Access Journals (Sweden)

    Ahmed Abdulhakim Al-Absi

    2015-01-01

    Full Text Available Genomic sequence alignment is an important technique to decode genome sequences in bioinformatics. Next-Generation Sequencing technologies produce genomic data of longer reads. Cloud platforms are adopted to address the problems arising from storage and analysis of large genomic data. Existing genes sequencing tools for cloud platforms predominantly consider short read gene sequences and adopt the Hadoop MapReduce framework for computation. However, serial execution of map and reduce phases is a problem in such systems. Therefore, in this paper, we introduce Burrows-Wheeler Aligner’s Smith-Waterman Alignment on Parallel MapReduce (BWASW-PMR cloud platform for long sequence alignment. The proposed cloud platform adopts a widely accepted and accurate BWA-SW algorithm for long sequence alignment. A custom MapReduce platform is developed to overcome the drawbacks of the Hadoop framework. A parallel execution strategy of the MapReduce phases and optimization of Smith-Waterman algorithm are considered. Performance evaluation results exhibit an average speed-up of 6.7 considering BWASW-PMR compared with the state-of-the-art Bwasw-Cloud. An average reduction of 30% in the map phase makespan is reported across all experiments comparing BWASW-PMR with Bwasw-Cloud. Optimization of Smith-Waterman results in reducing the execution time by 91.8%. The experimental study proves the efficiency of BWASW-PMR for aligning long genomic sequences on cloud platforms.

  19. Long Read Alignment with Parallel MapReduce Cloud Platform

    Science.gov (United States)

    Al-Absi, Ahmed Abdulhakim; Kang, Dae-Ki

    2015-01-01

    Genomic sequence alignment is an important technique to decode genome sequences in bioinformatics. Next-Generation Sequencing technologies produce genomic data of longer reads. Cloud platforms are adopted to address the problems arising from storage and analysis of large genomic data. Existing genes sequencing tools for cloud platforms predominantly consider short read gene sequences and adopt the Hadoop MapReduce framework for computation. However, serial execution of map and reduce phases is a problem in such systems. Therefore, in this paper, we introduce Burrows-Wheeler Aligner's Smith-Waterman Alignment on Parallel MapReduce (BWASW-PMR) cloud platform for long sequence alignment. The proposed cloud platform adopts a widely accepted and accurate BWA-SW algorithm for long sequence alignment. A custom MapReduce platform is developed to overcome the drawbacks of the Hadoop framework. A parallel execution strategy of the MapReduce phases and optimization of Smith-Waterman algorithm are considered. Performance evaluation results exhibit an average speed-up of 6.7 considering BWASW-PMR compared with the state-of-the-art Bwasw-Cloud. An average reduction of 30% in the map phase makespan is reported across all experiments comparing BWASW-PMR with Bwasw-Cloud. Optimization of Smith-Waterman results in reducing the execution time by 91.8%. The experimental study proves the efficiency of BWASW-PMR for aligning long genomic sequences on cloud platforms. PMID:26839887

  20. LabKey Server: An open source platform for scientific data integration, analysis and collaboration

    Science.gov (United States)

    2011-01-01

    Background Broad-based collaborations are becoming increasingly common among disease researchers. For example, the Global HIV Enterprise has united cross-disciplinary consortia to speed progress towards HIV vaccines through coordinated research across the boundaries of institutions, continents and specialties. New, end-to-end software tools for data and specimen management are necessary to achieve the ambitious goals of such alliances. These tools must enable researchers to organize and integrate heterogeneous data early in the discovery process, standardize processes, gain new insights into pooled data and collaborate securely. Results To meet these needs, we enhanced the LabKey Server platform, formerly known as CPAS. This freely available, open source software is maintained by professional engineers who use commercially proven practices for software development and maintenance. Recent enhancements support: (i) Submitting specimens requests across collaborating organizations (ii) Graphically defining new experimental data types, metadata and wizards for data collection (iii) Transitioning experimental results from a multiplicity of spreadsheets to custom tables in a shared database (iv) Securely organizing, integrating, analyzing, visualizing and sharing diverse data types, from clinical records to specimens to complex assays (v) Interacting dynamically with external data sources (vi) Tracking study participants and cohorts over time (vii) Developing custom interfaces using client libraries (viii) Authoring custom visualizations in a built-in R scripting environment. Diverse research organizations have adopted and adapted LabKey Server, including consortia within the Global HIV Enterprise. Atlas is an installation of LabKey Server that has been tailored to serve these consortia. It is in production use and demonstrates the core capabilities of LabKey Server. Atlas now has over 2,800 active user accounts originating from approximately 36 countries and 350

  1. LabKey Server: An open source platform for scientific data integration, analysis and collaboration

    Directory of Open Access Journals (Sweden)

    Lum Karl

    2011-03-01

    Full Text Available Abstract Background Broad-based collaborations are becoming increasingly common among disease researchers. For example, the Global HIV Enterprise has united cross-disciplinary consortia to speed progress towards HIV vaccines through coordinated research across the boundaries of institutions, continents and specialties. New, end-to-end software tools for data and specimen management are necessary to achieve the ambitious goals of such alliances. These tools must enable researchers to organize and integrate heterogeneous data early in the discovery process, standardize processes, gain new insights into pooled data and collaborate securely. Results To meet these needs, we enhanced the LabKey Server platform, formerly known as CPAS. This freely available, open source software is maintained by professional engineers who use commercially proven practices for software development and maintenance. Recent enhancements support: (i Submitting specimens requests across collaborating organizations (ii Graphically defining new experimental data types, metadata and wizards for data collection (iii Transitioning experimental results from a multiplicity of spreadsheets to custom tables in a shared database (iv Securely organizing, integrating, analyzing, visualizing and sharing diverse data types, from clinical records to specimens to complex assays (v Interacting dynamically with external data sources (vi Tracking study participants and cohorts over time (vii Developing custom interfaces using client libraries (viii Authoring custom visualizations in a built-in R scripting environment. Diverse research organizations have adopted and adapted LabKey Server, including consortia within the Global HIV Enterprise. Atlas is an installation of LabKey Server that has been tailored to serve these consortia. It is in production use and demonstrates the core capabilities of LabKey Server. Atlas now has over 2,800 active user accounts originating from approximately 36

  2. LabKey Server: an open source platform for scientific data integration, analysis and collaboration.

    Science.gov (United States)

    Nelson, Elizabeth K; Piehler, Britt; Eckels, Josh; Rauch, Adam; Bellew, Matthew; Hussey, Peter; Ramsay, Sarah; Nathe, Cory; Lum, Karl; Krouse, Kevin; Stearns, David; Connolly, Brian; Skillman, Tom; Igra, Mark

    2011-03-09

    Broad-based collaborations are becoming increasingly common among disease researchers. For example, the Global HIV Enterprise has united cross-disciplinary consortia to speed progress towards HIV vaccines through coordinated research across the boundaries of institutions, continents and specialties. New, end-to-end software tools for data and specimen management are necessary to achieve the ambitious goals of such alliances. These tools must enable researchers to organize and integrate heterogeneous data early in the discovery process, standardize processes, gain new insights into pooled data and collaborate securely. To meet these needs, we enhanced the LabKey Server platform, formerly known as CPAS. This freely available, open source software is maintained by professional engineers who use commercially proven practices for software development and maintenance. Recent enhancements support: (i) Submitting specimens requests across collaborating organizations (ii) Graphically defining new experimental data types, metadata and wizards for data collection (iii) Transitioning experimental results from a multiplicity of spreadsheets to custom tables in a shared database (iv) Securely organizing, integrating, analyzing, visualizing and sharing diverse data types, from clinical records to specimens to complex assays (v) Interacting dynamically with external data sources (vi) Tracking study participants and cohorts over time (vii) Developing custom interfaces using client libraries (viii) Authoring custom visualizations in a built-in R scripting environment. Diverse research organizations have adopted and adapted LabKey Server, including consortia within the Global HIV Enterprise. Atlas is an installation of LabKey Server that has been tailored to serve these consortia. It is in production use and demonstrates the core capabilities of LabKey Server. Atlas now has over 2,800 active user accounts originating from approximately 36 countries and 350 organizations. It tracks

  3. Delivering on Industry Equipment Reliability Goals By Leveraging an Integration Platform and Decision Support Environment

    International Nuclear Information System (INIS)

    Coveney, Maureen K.; Bailey, W. Henry; Parkinson, William

    2004-01-01

    Utilities have invested in many costly enterprise systems - computerized maintenance management systems, document management systems, enterprise grade portals, to name but a few - and often very specialized systems, like data historians, high end diagnostic systems, and other focused and point solutions. From recent industry reports, we now know that the average nuclear power utilizes on average 1900 systems to perform daily work, of which 250 might facilitate the equipment reliability decision-making process. The time has come to leverage the investment in these systems by providing a common platform for integration and decision-making that will further the collective industry aim of enhancing the reliability of our nuclear generation assets to maintain high plant availability and to deliver on plant life extension goals without requiring additional large scale investment in IT infrastructure. (authors)

  4. Typology of person-environment fit constellations: a platform addressing accessibility problems in the built environment for people with functional limitations.

    Science.gov (United States)

    Slaug, Björn; Schilling, Oliver; Iwarsson, Susanne; Carlsson, Gunilla

    2015-09-02

    Making the built environment accessible for all regardless of functional capacity is an important goal for public health efforts. Considerable impediments to achieving this goal suggest the need for valid measurements of acccessibility and for greater attention to the complexity of person-environment fit issues. To address these needs, this study aimed to provide a methodological platform, useful for further research and instrument development within accessibility research. This was accomplished by the construction of a typology of problematic person-environment fit constellations, utilizing an existing methodology developed to assess and analyze accessibility problems in the built environment. By means of qualitative review and statistical methods we classified the person-environment fit components covered by an existing application which targets housing accessibility: the Housing Enabler (HE) instrument. The International Classification of Functioning, Disability and Health (ICF) was used as a conceptual framework. Qualitative classification principles were based on conceptual similarities and for quantitative analysis of similarities, Principal Component Analysis was carried out. We present a typology of problematic person-environment fit constellations classified along three dimensions: 1) accessibility problem range and severity 2) aspects of functioning 3) environmental context. As a result of the classification of the HE components, 48 typical person-environment fit constellations were recognised. The main contribution of this study is the proposed typology of person-environment fit constellations. The typology provides a methodological platform for the identification and quantification of problematic person-environment fit constellations. Its link to the globally accepted ICF classification system facilitates communication within the scientific and health care practice communities. The typology also highlights how relations between aspects of functioning

  5. Model correction factor method for reliability problems involving integrals of non-Gaussian random fields

    DEFF Research Database (Denmark)

    Franchin, P.; Ditlevsen, Ove Dalager; Kiureghian, Armen Der

    2002-01-01

    The model correction factor method (MCFM) is used in conjunction with the first-order reliability method (FORM) to solve structural reliability problems involving integrals of non-Gaussian random fields. The approach replaces the limit-state function with an idealized one, in which the integrals ...

  6. Intrant ELISA: A Novel Approach to Fabrication of Electrospun Fiber Mat-Assisted Biosensor Platforms and Their Integration within Standard Analytical Well Plates

    Directory of Open Access Journals (Sweden)

    Samira Hosseini

    2016-11-01

    Full Text Available A combination of far-field electrospinning (FFES and free-radical polymerization has been used to fabricate coated electrospun polymer fiber mats as a new type of biosensor platform. Poly (3-hydroxybutyrate-co-3-hydroxyvalerate (PHBV electrospun fibers were dip-coated with different compositions of poly methyl methacrylate-co-methacrylic acid (poly(MMA-co-MAA. This synergistic approach utilizes large specific surface area of PHBV fibers and co-polymer coatings that feature an optimum concentration of surface carboxyl (–COOH groups. The platform surface morphology, porosity and tunable hydrophobicity enhance biomolecular interactions via plurality of molecular forces. These customized fiber mats have been integrated into a newly designed 96-well plate called an “intrant enzyme-linked immunosorbent assay” or i-ELISA. I-ELISA allows colorimetric sandwich assay to be carried out without any modifications or additional steps in ELISA methodology. By introducing the fiber mats in fabrication of i-ELISA via extensions on the lid, we address some of the limitations of the previous designs while demonstrating an enhanced signal intensity up to 12 times higher than that of conventional assays. With improved sensitivity, specificity and accuracy in the detection of dengue virus, i-ELISA has proven to be a reliable platform for biomolecular recognition. The proposed fiber mat-assisted well plate in this study holds great potential as a universal approach for integration of different types of fiber mats with pre-designed specific properties in order to enhance the detection sensitivity of the assay.

  7. AZTLAN platform: Mexican platform for analysis and design of nuclear reactors

    International Nuclear Information System (INIS)

    Gomez T, A. M.; Puente E, F.; Del Valle G, E.; Francois L, J. L.; Martin del Campo M, C.; Espinosa P, G.

    2014-10-01

    The Aztlan platform Project is a national initiative led by the Instituto Nacional de Investigaciones Nucleares (ININ) which brings together the main public houses of higher studies in Mexico, such as: Instituto Politecnico Nacional, Universidad Nacional Autonoma de Mexico and Universidad Autonoma Metropolitana in an effort to take a significant step toward the calculation autonomy and analysis that seeks to place Mexico in the medium term in a competitive international level on software issues for analysis of nuclear reactors. This project aims to modernize, improve and integrate the neutron, thermal-hydraulic and thermo-mechanical codes, developed in Mexican institutions, within an integrated platform, developed and maintained by Mexican experts to benefit from the same institutions. This project is financed by the mixed fund SENER-CONACYT of Energy Sustain ability, and aims to strengthen substantially to research institutions, such as educational institutions contributing to the formation of highly qualified human resources in the area of analysis and design of nuclear reactors. As innovative part the project includes the creation of a user group, made up of members of the project institutions as well as the Comision Nacional de Seguridad Nuclear y Salvaguardias, Central Nucleoelectrica de Laguna Verde (CNLV), Secretaria de Energia (Mexico) and Karlsruhe Institute of Technology (Germany) among others. This user group will be responsible for using the software and provide feedback to the development equipment in order that progress meets the needs of the regulator and industry; in this case the CNLV. Finally, in order to bridge the gap between similar developments globally, they will make use of the latest super computing technology to speed up calculation times. This work intends to present to national nuclear community the project, so a description of the proposed methodology is given, as well as the goals and objectives to be pursued for the development of the

  8. A Droplet Microfluidic Platform for Automating Genetic Engineering.

    Science.gov (United States)

    Gach, Philip C; Shih, Steve C C; Sustarich, Jess; Keasling, Jay D; Hillson, Nathan J; Adams, Paul D; Singh, Anup K

    2016-05-20

    We present a water-in-oil droplet microfluidic platform for transformation, culture and expression of recombinant proteins in multiple host organisms including bacteria, yeast and fungi. The platform consists of a hybrid digital microfluidic/channel-based droplet chip with integrated temperature control to allow complete automation and integration of plasmid addition, heat-shock transformation, addition of selection medium, culture, and protein expression. The microfluidic format permitted significant reduction in consumption (100-fold) of expensive reagents such as DNA and enzymes compared to the benchtop method. The chip contains a channel to continuously replenish oil to the culture chamber to provide a fresh supply of oxygen to the cells for long-term (∼5 days) cell culture. The flow channel also replenished oil lost to evaporation and increased the number of droplets that could be processed and cultured. The platform was validated by transforming several plasmids into Escherichia coli including plasmids containing genes for fluorescent proteins GFP, BFP and RFP; plasmids with selectable markers for ampicillin or kanamycin resistance; and a Golden Gate DNA assembly reaction. We also demonstrate the applicability of this platform for transformation in widely used eukaryotic organisms such as Saccharomyces cerevisiae and Aspergillus niger. Duration and temperatures of the microfluidic heat-shock procedures were optimized to yield transformation efficiencies comparable to those obtained by benchtop methods with a throughput up to 6 droplets/min. The proposed platform offers potential for automation of molecular biology experiments significantly reducing cost, time and variability while improving throughput.

  9. Effects of performance feedback and coaching on the problem-solving process: Improving the integrity of implementation and enhancing student outcomes

    Science.gov (United States)

    Lundahl, Allison A.

    Schools implementing Response to Intervention (RtI) procedures frequently engage in team problem-solving processes to address the needs of students who require intensive and individualized services. Because the effectiveness of the problem-solving process will impact the overall success of RtI systems, the present study was designed to learn more about how to strengthen the integrity of the problem-solving process. Research suggests that school districts must ensure high quality training and ongoing support to enhance the effectiveness, acceptability, and sustainability of the problem-solving process within an RtI model; however, there is a dearth of research examining the effectiveness of methods to provide this training and support. Consequently, this study investigated the effects of performance feedback and coaching strategies on the integrity with which teams of educators conducted the problem-solving process in schools. In addition, the relationships between problem-solving integrity, teacher acceptability, and student outcomes were examined. Results suggested that the performance feedback increased problem-solving procedural integrity across two of the three participating schools. Conclusions about the effectiveness of the (a) coaching intervention and (b) interventions implemented in the third school were inconclusive. Regression analyses indicated that the integrity with which the teams conducted the problem-solving process was a significant predictor of student outcomes. However, the relationship between problem-solving procedural integrity and teacher acceptability was not statistically significant.

  10. Integrating video and animation with physics problem- solving exercises on the World Wide Web

    Science.gov (United States)

    Titus, Aaron Patrick

    1998-10-01

    Problem solving is of paramount importance in teaching and learning physics. An important step in solving a problem is visualization. To help students visualize a problem, we included video clips with homework questions delivered via the World Wide Web. Although including video with physics problems has a positive effect with some problems, we found that this may not be the best way to integrate multimedia with physics problems since improving visualization is probably not as helpful as changing students' approach. To challenge how students solve problems and to help them develop a more expert-like approach, we developed a type of physics exercise called a multimedia-focused problem where students take data from an animation in order to solve a problem. Because numbers suggestive of a solution are not given in the text of the question, students have to consider the problem conceptually before analyzing it mathematically. As a result, we found that students had difficulty solving such problems compared to traditional textbook-like problems. Students' survey responses showed that students indeed had difficulty determining what was needed to solve a problem when it was not explicitly given to them in the text of the question. Analyzing think-aloud interviews where students verbalized their thoughts while solving problems, we found that multimedia-focused problems indeed required solid conceptual understanding in order for them to be solved correctly. As a result, we believe that when integrated with instruction, multimedia-focused problems can be a valuable tool in helping students develop better conceptual understanding and more expert-like problem solving skills by challenging novice beliefs and problem solving approaches. Multimedia-focused problems may also be useful for diagnosing conceptual understanding and problem skills.

  11. [Ethical problems experienced by nurses in primary health care: integrative literature review].

    Science.gov (United States)

    Nora, Carlise Rigon Dalla; Zoboli, Elma Lourdes Campos Pavone; Vieira, Margarida

    2015-03-01

    The aim of this study is to identify ethical problems experienced by nurses in primary health care and resources for coping based on publications on the subject. An integrative literature review was performed between the months of October and November 2013, using the databases: BDTD, CINAHL, LILACS, MEDLINE, Biblioteca Cochrane, PubMed, RCAAP and SciELO. Articles, dissertations and theses published in Portuguese, English and Spanish were included, totalling 31 studies published from 1992 to 2013. This analysis resulted in four categories: ethical problems in the relationship between team members, ethical problems in the relationship with the user, ethical problems in health services management and resources for coping with ethical problems. Results showed that nurses need to be prepared to face ethical problems, emphasizing the importance of ethics education during the education process before and during professional practice to enhance the development of ethical sensitivity and competence for problem resolution.

  12. The problems concerning the integration of very thin mirror shells

    Science.gov (United States)

    Basso, S.; Citterio, O.; Mazzoleni, F.; Pareschi, G.; Tagliaferri, G.; Valtolina, R.; Conconi, P.; Parodi, G.

    2009-08-01

    The necessity to reduce the mass and to increase the collecting area requires that the thickness of the optics becomes more and more thinner. Simbol-X was a typical example of this trend. Such thickness makes the shells floppy and therefore unable to maintain the correct shape. During the integration of the shells into the mechanical structure, only negligible deformation must be introduced. The low thickness means also that the shells must be glued on both sides to reach a good stiffness of the whole mirror module and this fact introduces a set of mounting problems. In INAF - Osservatorio Astronomico di Brera an integration process has been developed. The use of stiffening rings and of a temporary structure is the key to maintain the right shape of the shell. In this article the results of the integration of the first three prototypes of the Simbol-X optics are presented. The description of the process and the analysis of the degradation of the performances during the integration are shown in detail.

  13. Technical Research on the Electric Power Big Data Platform of Smart Grid

    OpenAIRE

    Ruiguang MA; Haiyan Wang; Quanming Zhang; Yuan Liang

    2017-01-01

    Through elaborating on the associated relationship among electric power big data, cloud computing and smart grid, this paper put forward general framework of electric power big data platform based on the smart grid. The general framework of the platform is divided into five layers, namely data source layer, data integration and storage layer, data processing and scheduling layer, data analysis layer and application layer. This paper makes in-depth exploration and studies the integrated manage...

  14. Reinventing the Platform Core Through Acquisition

    DEFF Research Database (Denmark)

    Toppenberg, Gustav; Henningsson, Stefan; Eaton, Ben

    2016-01-01

    the acquisition and integration of companies presenting innovative technologies of relevance to the platform core. Using a revelatory case study of Cisco Systems, we develop the explanatory notion of ‘coring acquisition’. In this type of acquisition value is created through the acquisition of companies...

  15. Planning lessons with learning platforms - problem and prospects for mathematics education

    DEFF Research Database (Denmark)

    Tamborg, Andreas Lindenskov

    2018-01-01

    is a key intention behind the implementation of the platform. It is also concluded that when the teachers succeed in using learning objectives actively in their planning, the objectives support the teachers in designing lessons that correspond with their intentions. The paper concludes with a discussion...

  16. Nuclear thermionic power plant integration problems

    International Nuclear Information System (INIS)

    Fraas, A.P.

    1967-02-01

    The numerous boundary conditions to be met in preparing a well proportioned, properly integrated design for a thermionic cell reactor are discussed with the emphasis on materials and fabrication problems. Pertinent experience with fuel elements, tube header sheets, electric heaters, and pressure vessels is cited to highlight key limitations that have been encountered in structurally similar equipment. A reference design is presented to indicate how one might attempt to satisfy all of the many boundary conditions. The study indicates that it will be difficult to get a reactor core power density greater than about 35 w/cm 3 and that, while it is possible to minimize the ill effects of failures within individual cells by employing series-parallel connections, the study further indicates that there is inherently a high probability of leaks and electrical shorts and arcs within the reactor so that it is doubtful that good reliability can be obtained

  17. Integrating Multimedia and Physics Problems

    Science.gov (United States)

    Titus, Aaron P.

    1997-11-01

    Although expert problem solvers typically use pictorial representations when solving problems, novices tend to proceed from the given problem statement to a mathematical solution without first developing a visual representation of the problem. For this reason, multimedia may be an effective tool to enhance students' success at solving problems. However, merely presenting a video of motion described in a problem is not necessarily the most effective method as was found in a recent study of students' responses on Web-based homework questions. Rather, multimedia-focused problems, where data relevant to solving the problem is embedded in a video or animation, may be the best use of multimedia in problem solving. Examples of multimedia-enhanced problems and multimedia-focused problems will be demonstrated, and their differences from "traditional" problems will be highlighted. Recommendations on the use of multimedia with problem solving and preliminary data on students' success at solving these problems will be discussed.

  18. Using fuzzy analytical hierarchy process (AHP to evaluate web development platform

    Directory of Open Access Journals (Sweden)

    Ahmad Sarfaraz

    2012-01-01

    Full Text Available Web development is plays an important role on business plans and people's lives. One of the key decisions in which both short-term and long-term success of the project depends is choosing the right development platform. Its criticality can be judged by the fact that once a platform is chosen, one has to live with it throughout the software development life cycle. The entire shape of the project depends on the language, operating system, tools, frameworks etc., in short the web development platform chosen. In addition, choosing the right platform is a multi criteria decision making (MCDM problem. We propose a fuzzy analytical hierarchy process model to solve the MCDM problem. We try to tap the real-life modeling potential of fuzzy logic and conjugate it with the commonly used powerful AHP modeling method.

  19. The integration of FMEA with other problem solving tools: A review of enhancement opportunities

    Science.gov (United States)

    Ng, W. C.; Teh, S. Y.; Low, H. C.; Teoh, P. C.

    2017-09-01

    Failure Mode Effect Analysis (FMEA) is one the most effective and accepted problem solving (PS) tools for most of the companies in the world. Since FMEA was first introduced in 1949, practitioners have implemented FMEA in various industries for their quality improvement initiatives. However, studies have shown that there are drawbacks that hinder the effectiveness of FMEA for continuous quality improvement from product design to manufacturing. Therefore, FMEA is integrated with other PS tools such as inventive problem solving methodology (TRIZ), Quality Function Deployment (QFD), Root Cause Analysis (RCA) and seven basic tools of quality to address the drawbacks. This study begins by identifying the drawbacks in FMEA. A comprehensive literature review on the integration of FMEA with other tools is carried out to categorise the integrations based on the drawbacks identified. The three categories are inefficiency of failure analysis, psychological inertia and neglect of customers’ perspective. This study concludes by discussing the gaps and opportunities in the integration for future research.

  20. Contribution to global computation infrastructure: inter-platform delegation, integration of standard services and application to high-energy physics

    International Nuclear Information System (INIS)

    Lodygensky, Oleg

    2006-01-01

    The generalization and implementation of the current information resources, particularly the large storing capacities and the networks allow conceiving new methods of work and ways of entertainment. Centralized stand-alone, monolithic computing stations have been gradually replaced by distributed client-tailored architectures which in turn are challenged by the new distributed systems called 'pair-by pair' systems. This migration is no longer with the specialists' realm but users of more modest skills get used with this new techniques for e-mailing commercial information and exchanging various sorts of files on a 'equal-to-equal' basis. Trade, industry and research as well make profits largely of the new technique called 'grid', this new technique of handling information at a global scale. The present work concerns the grid utilisation for computation. A synergy was created with Paris-Sud University at Orsay, between the Information Research Laboratory (LRI) and the Linear Accelerator Laboratory (LAL) in order to foster the works on grid infrastructure of high research interest for LRI and offering new working methods for LAL. The results of the work developed within this inter-disciplinary-collaboration are based on XtremWeb, the research and production platform for global computation elaborated at LRI. First one presents the current status of the large-scale distributed systems, their basic principles and user-oriented architecture. The XtremWeb is then described focusing the modifications which were effected upon both architecture and implementation in order to fulfill optimally the requirements imposed to such a platform. Then one presents studies with the platform allowing a generalization of the inter-grid resources and development of a user-oriented grid adapted to special services, as well,. Finally one presents the operation modes, the problems to solve and the advantages of this new platform for the high-energy research community, the most demanding

  1. Design optimization and tolerance analysis of a spot-size converter for the taper-assisted vertical integration platform in InP.

    Science.gov (United States)

    Tolstikhin, Valery; Saeidi, Shayan; Dolgaleva, Ksenia

    2018-05-01

    We report on the design optimization and tolerance analysis of a multistep lateral-taper spot-size converter based on indium phosphide (InP), performed using the Monte Carlo method. Being a natural fit to (and a key building block of) the regrowth-free taper-assisted vertical integration platform, such a spot-size converter enables efficient and displacement-tolerant fiber coupling to InP-based photonic integrated circuits at a wavelength of 1.31 μm. An exemplary four-step lateral-taper design featuring 0.35 dB coupling loss at optimal alignment of a standard single-mode fiber; ≥7  μm 1 dB displacement tolerance in any direction in a facet plane; and great stability against manufacturing variances is demonstrated.

  2. The Information Management Platform on Nuclear Emergency Resources of China

    International Nuclear Information System (INIS)

    Dong, L.

    2016-01-01

    Full text: The Chinese government has always attached great importance to nuclear emergency work, and has invested to form lots of nuclear emergency resources. Meanwhile, there also exist some management problems such as repeated investment, fragmented inventory list, inefficient management, etc. To achieve integrated management on the nuclear emergency resources of China, the Chinese government initiated the project “The Information Management Platform on Nuclear Emergency Resources of China”. The goal of the project is to support a timely, managed, controlled, coordinated and effective response while the resources managing process remains economically efficient. The project team firstly completed the nuclear emergency resources classification and encoding. Based on these, the nuclear emergency resources information management software system was developed. The pilot operation in the system was carried out both in Guangxi and Liaoning Province at the same time. Nuclear emergency resources survey was done as the relevant information was put into the database in these regions. The evaluation result on the pilot operation showed that, the information management platform on emergency resources would apparently improve efficiency of nuclear emergency preparedness and response, and it also would increase economical efficiency on inventory list, information management and invest decision. (author

  3. Developing an integrated, Internet-based self-help programme for young people with depression and alcohol use problems

    Directory of Open Access Journals (Sweden)

    Mark Deady

    2014-07-01

    Overall, the DEAL Project programme was well-received and provides an innovative new platform for the treatment of co-occurring depression and alcohol use problems in young people. The next phase will include an evaluation of programme efficacy. If found to be efficacious, the programme has the potential to improve outcomes, reduce disease burden, and increase treatment uptake in this vulnerable group.

  4. Platform for efficient switching between multiple devices in the intensive care unit.

    Science.gov (United States)

    De Backere, F; Vanhove, T; Dejonghe, E; Feys, M; Herinckx, T; Vankelecom, J; Decruyenaere, J; De Turck, F

    2015-01-01

    This article is part of the Focus Theme of METHODS of Information in Medicine on "Managing Interoperability and Complexity in Health Systems". Handheld computers, such as tablets and smartphones, are becoming more and more accessible in the clinical care setting and in Intensive Care Units (ICUs). By making the most useful and appropriate data available on multiple devices and facilitate the switching between those devices, staff members can efficiently integrate them in their workflow, allowing for faster and more accurate decisions. This paper addresses the design of a platform for the efficient switching between multiple devices in the ICU. The key functionalities of the platform are the integration of the platform into the workflow of the medical staff and providing tailored and dynamic information at the point of care. The platform is designed based on a 3-tier architecture with a focus on extensibility, scalability and an optimal user experience. After identification to a device using Near Field Communication (NFC), the appropriate medical information will be shown on the selected device. The visualization of the data is adapted to the type of the device. A web-centric approach was used to enable extensibility and portability. A prototype of the platform was thoroughly evaluated. The scalability, performance and user experience were evaluated. Performance tests show that the response time of the system scales linearly with the amount of data. Measurements with up to 20 devices have shown no performance loss due to the concurrent use of multiple devices. The platform provides a scalable and responsive solution to enable the efficient switching between multiple devices. Due to the web-centric approach new devices can easily be integrated. The performance and scalability of the platform have been evaluated and it was shown that the response time and scalability of the platform was within an acceptable range.

  5. a Real-Time GIS Platform for High Sour Gas Leakage Simulation, Evaluation and Visualization

    Science.gov (United States)

    Li, M.; Liu, H.; Yang, C.

    2015-07-01

    The development of high-sulfur gas fields, also known as sour gas field, is faced with a series of safety control and emergency management problems. The GIS-based emergency response system is placed high expectations under the consideration of high pressure, high content, complex terrain and highly density population in Sichuan Basin, southwest China. The most researches on high hydrogen sulphide gas dispersion simulation and evaluation are used for environmental impact assessment (EIA) or emergency preparedness planning. This paper introduces a real-time GIS platform for high-sulfur gas emergency response. Combining with real-time data from the leak detection systems and the meteorological monitoring stations, GIS platform provides the functions of simulating, evaluating and displaying of the different spatial-temporal toxic gas distribution patterns and evaluation results. This paper firstly proposes the architecture of Emergency Response/Management System, secondly explains EPA's Gaussian dispersion model CALPUFF simulation workflow under high complex terrain and real-time data, thirdly explains the emergency workflow and spatial analysis functions of computing the accident influencing areas, population and the optimal evacuation routes. Finally, a well blow scenarios is used for verify the system. The study shows that GIS platform which integrates the real-time data and CALPUFF models will be one of the essential operational platforms for high-sulfur gas fields emergency management.

  6. Implementation of Online Veterinary Hospital on Cloud Platform.

    Science.gov (United States)

    Chen, Tzer-Shyong; Chen, Tzer-Long; Chung, Yu-Fang; Huang, Yao-Min; Chen, Tao-Chieh; Wang, Huihui; Wei, Wei

    2016-06-01

    Pet markets involve in great commercial possibilities, which boost thriving development of veterinary hospital businesses. The service tends to intensive competition and diversified channel environment. Information technology is integrated for developing the veterinary hospital cloud service platform. The platform contains not only pet medical services but veterinary hospital management and services. In the study, QR Code andcloud technology are applied to establish the veterinary hospital cloud service platform for pet search by labeling a pet's identification with QR Code. This technology can break the restriction on veterinary hospital inspection in different areas and allows veterinary hospitals receiving the medical records and information through the exclusive QR Code for more effective inspection. As an interactive platform, the veterinary hospital cloud service platform allows pet owners gaining the knowledge of pet diseases and healthcare. Moreover, pet owners can enquire and communicate with veterinarians through the platform. Also, veterinary hospitals can periodically send reminders of relevant points and introduce exclusive marketing information with the platform for promoting the service items and establishing individualized marketing. Consequently, veterinary hospitals can increase the profits by information share and create the best solution in such a competitive veterinary market with industry alliance.

  7. Cross-Platform Mobile Application Development: A Pattern-Based Approach

    Science.gov (United States)

    2012-03-01

    TYPE AND DATES COVERED Master’s Thesis 4. TITLE AND SUBTITLE Cross-Platform Mobile Application Development: A Pattern-Based Approach 5. FUNDING...for public release; distribution is unlimited CROSS-PLATFORM MOBILE APPLICATION DEVELOPMENT: A PATTERN-BASED APPROACH Christian G. Acord...occurring design problems. We then discuss common approaches to mobile development, including common aspects of mobile application development, including

  8. Design and simulation of material-integrated distributed sensor processing with a code-based agent platform and mobile multi-agent systems.

    Science.gov (United States)

    Bosse, Stefan

    2015-02-16

    Multi-agent systems (MAS) can be used for decentralized and self-organizing data processing in a distributed system, like a resource-constrained sensor network, enabling distributed information extraction, for example, based on pattern recognition and self-organization, by decomposing complex tasks in simpler cooperative agents. Reliable MAS-based data processing approaches can aid the material-integration of structural-monitoring applications, with agent processing platforms scaled to the microchip level. The agent behavior, based on a dynamic activity-transition graph (ATG) model, is implemented with program code storing the control and the data state of an agent, which is novel. The program code can be modified by the agent itself using code morphing techniques and is capable of migrating in the network between nodes. The program code is a self-contained unit (a container) and embeds the agent data, the initialization instructions and the ATG behavior implementation. The microchip agent processing platform used for the execution of the agent code is a standalone multi-core stack machine with a zero-operand instruction format, leading to a small-sized agent program code, low system complexity and high system performance. The agent processing is token-queue-based, similar to Petri-nets. The agent platform can be implemented in software, too, offering compatibility at the operational and code level, supporting agent processing in strong heterogeneous networks. In this work, the agent platform embedded in a large-scale distributed sensor network is simulated at the architectural level by using agent-based simulation techniques.

  9. Design and Simulation of Material-Integrated Distributed Sensor Processing with a Code-Based Agent Platform and Mobile Multi-Agent Systems

    Directory of Open Access Journals (Sweden)

    Stefan Bosse

    2015-02-01

    Full Text Available Multi-agent systems (MAS can be used for decentralized and self-organizing data processing in a distributed system, like a resource-constrained sensor network, enabling distributed information extraction, for example, based on pattern recognition and self-organization, by decomposing complex tasks in simpler cooperative agents. Reliable MAS-based data processing approaches can aid the material-integration of structural-monitoring applications, with agent processing platforms scaled to the microchip level. The agent behavior, based on a dynamic activity-transition graph (ATG model, is implemented with program code storing the control and the data state of an agent, which is novel. The program code can be modified by the agent itself using code morphing techniques and is capable of migrating in the network between nodes. The program code is a self-contained unit (a container and embeds the agent data, the initialization instructions and the ATG behavior implementation. The microchip agent processing platform used for the execution of the agent code is a standalone multi-core stack machine with a zero-operand instruction format, leading to a small-sized agent program code, low system complexity and high system performance. The agent processing is token-queue-based, similar to Petri-nets. The agent platform can be implemented in software, too, offering compatibility at the operational and code level, supporting agent processing in strong heterogeneous networks. In this work, the agent platform embedded in a large-scale distributed sensor network is simulated at the architectural level by using agent-based simulation techniques.

  10. CLOUD BASED WEB 3D GIS TAIWAN PLATFORM

    Directory of Open Access Journals (Sweden)

    W.-F. Tsai

    2012-09-01

    Full Text Available This article presents the status of the web 3D GIS platform, which has been developed in the National Applied Research Laboratories. The purpose is to develop a global earth observation 3D GIS platform for applications to disaster monitoring and assessment in Taiwan. For quick response to preliminary and detailed assessment after a natural disaster occurs, the web 3D GIS platform is useful to access, transfer, integrate, display and analyze the multi-scale huge data following the international OGC standard. The framework of cloud service for data warehousing management and efficiency enhancement using VMWare is illustrated in this article.

  11. IMPACT_S: integrated multiprogram platform to analyze and combine tests of selection.

    Directory of Open Access Journals (Sweden)

    Emanuel Maldonado

    Full Text Available Among the major goals of research in evolutionary biology are the identification of genes targeted by natural selection and understanding how various regimes of evolution affect the fitness of an organism. In particular, adaptive evolution enables organisms to adapt to changing ecological factors such as diet, temperature, habitat, predatory pressures and prey abundance. An integrative approach is crucial for the identification of non-synonymous mutations that introduce radical changes in protein biochemistry and thus in turn influence the structure and function of proteins. Performing such analyses manually is often a time-consuming process, due to the large number of statistical files generated from multiple approaches, especially when assessing numerous taxa and/or large datasets. We present IMPACT_S, an easy-to-use Graphical User Interface (GUI software, which rapidly and effectively integrates, filters and combines results from three widely used programs for assessing the influence of selection: Codeml (PAML package, Datamonkey and TreeSAAP. It enables the identification and tabulation of sites detected by these programs as evolving under the influence of positive, neutral and/or negative selection in protein-coding genes. IMPACT_S further facilitates the automatic mapping of these sites onto the three-dimensional structures of proteins. Other useful tools incorporated in IMPACT_S include Jmol, Archaeopteryx, Gnuplot, PhyML, a built-in Swiss-Model interface and a PDB downloader. The relevance and functionality of IMPACT_S is shown through a case study on the toxicoferan-reptilian Cysteine-rich Secretory Proteins (CRiSPs. IMPACT_S is a platform-independent software released under GPLv3 license, freely available online from http://impact-s.sourceforge.net.

  12. IMPACT_S: integrated multiprogram platform to analyze and combine tests of selection.

    Science.gov (United States)

    Maldonado, Emanuel; Sunagar, Kartik; Almeida, Daniela; Vasconcelos, Vitor; Antunes, Agostinho

    2014-01-01

    Among the major goals of research in evolutionary biology are the identification of genes targeted by natural selection and understanding how various regimes of evolution affect the fitness of an organism. In particular, adaptive evolution enables organisms to adapt to changing ecological factors such as diet, temperature, habitat, predatory pressures and prey abundance. An integrative approach is crucial for the identification of non-synonymous mutations that introduce radical changes in protein biochemistry and thus in turn influence the structure and function of proteins. Performing such analyses manually is often a time-consuming process, due to the large number of statistical files generated from multiple approaches, especially when assessing numerous taxa and/or large datasets. We present IMPACT_S, an easy-to-use Graphical User Interface (GUI) software, which rapidly and effectively integrates, filters and combines results from three widely used programs for assessing the influence of selection: Codeml (PAML package), Datamonkey and TreeSAAP. It enables the identification and tabulation of sites detected by these programs as evolving under the influence of positive, neutral and/or negative selection in protein-coding genes. IMPACT_S further facilitates the automatic mapping of these sites onto the three-dimensional structures of proteins. Other useful tools incorporated in IMPACT_S include Jmol, Archaeopteryx, Gnuplot, PhyML, a built-in Swiss-Model interface and a PDB downloader. The relevance and functionality of IMPACT_S is shown through a case study on the toxicoferan-reptilian Cysteine-rich Secretory Proteins (CRiSPs). IMPACT_S is a platform-independent software released under GPLv3 license, freely available online from http://impact-s.sourceforge.net.

  13. Problems of Development and Integration of the Securities Market in the Countries of the EAEU

    Directory of Open Access Journals (Sweden)

    Ashot Bayadyan

    2017-12-01

    Full Text Available The article is devoted to studying problems associated with the development and integration of the securities market in the countries of the Eurasian Economic Union. The article examines the present state, possibilities and problems pertaining to the development of the securities market and, in particular, the regulated market. The development and integration of the securities market is an important factor affecting the potential for economic development and sustainable economic growth in the countries of the Eurasian Economic Union. The subject of this study is the development and integration problems affecting the securities market in the countries of the Eurasian Economic Union. The securities market in the countries of the Eurasian Economic Union has sufficient integration opportunities. Potential exists in all segments of the securities market, but more opportunities exist in the debt securities market. The deepening of the integration processes in the securities market of the countries of the Eurasian Economic Union could have a positive impact on increasing the investment opportunities of the economies of these countries. This, in turn, can have a positive impact on the growth of the gross domestic product, reducing unemployment and improving the social status of the population. However, the creation of a single or integrated exchange market should be accompanied by the integration of depository processes as well as the settlement and clearing systems, and the synchronizing of the regulatory and legal framework governing the securities market. Particular attention is required to study the problems associated with fixing and transferring property rights to the securities and protecting the interests of investors. The integration processes of depository, settlement and clearing systems may include the introduction of a nominee holder for central depositories and the establishment of correspondent relations between the central depositories

  14. Experimental Peptide Identification Repository (EPIR): an integrated peptide-centric platform for validation and mining of tandem mass spectrometry data

    DEFF Research Database (Denmark)

    Kristensen, Dan Bach; Brønd, Jan Christian; Nielsen, Peter Aagaard

    2004-01-01

    LC MS/MS has become an established technology in proteomic studies, and with the maturation of the technology the bottleneck has shifted from data generation to data validation and mining. To address this bottleneck we developed Experimental Peptide Identification Repository (EPIR), which...... is an integrated software platform for storage, validation, and mining of LC MS/MS-derived peptide evidence. EPIR is a cumulative data repository where precursor ions are linked to peptide assignments and protein associations returned by a search engine (e.g. Mascot, Sequest, or PepSea). Any number of datasets can...

  15. Well Connected, a platform for safe online communication and therapy

    NARCIS (Netherlands)

    Postel, Marloes Gerda; van Regteren, B.J.

    2012-01-01

    Well Connected, a platform for safe online communication and therapy Introduction Well Connected is a flexible, safe and user friendly e-health platform with a wide range of applications. Over the last 7 years 5000 patients were treated or a variety of addiction related problems. Besides creating an

  16. A platform for rapid prototyping of synthetic gene networks in mammalian cells

    Science.gov (United States)

    Duportet, Xavier; Wroblewska, Liliana; Guye, Patrick; Li, Yinqing; Eyquem, Justin; Rieders, Julianne; Rimchala, Tharathorn; Batt, Gregory; Weiss, Ron

    2014-01-01

    Mammalian synthetic biology may provide novel therapeutic strategies, help decipher new paths for drug discovery and facilitate synthesis of valuable molecules. Yet, our capacity to genetically program cells is currently hampered by the lack of efficient approaches to streamline the design, construction and screening of synthetic gene networks. To address this problem, here we present a framework for modular and combinatorial assembly of functional (multi)gene expression vectors and their efficient and specific targeted integration into a well-defined chromosomal context in mammalian cells. We demonstrate the potential of this framework by assembling and integrating different functional mammalian regulatory networks including the largest gene circuit built and chromosomally integrated to date (6 transcription units, 27kb) encoding an inducible memory device. Using a library of 18 different circuits as a proof of concept, we also demonstrate that our method enables one-pot/single-flask chromosomal integration and screening of circuit libraries. This rapid and powerful prototyping platform is well suited for comparative studies of genetic regulatory elements, genes and multi-gene circuits as well as facile development of libraries of isogenic engineered cell lines. PMID:25378321

  17. Ethical problems experienced by nurses in primary health care: integrative literature review

    Directory of Open Access Journals (Sweden)

    Carlise Rigon Dalla Nora

    Full Text Available The aim of this study is to identify ethical problems experienced by nurses in primary health care and resources for coping based on publications on the subject. An integrative literature review was performed between the months of October and November 2013, using the databases: BDTD, CINAHL, LILACS, MEDLINE, Biblioteca Cochrane, PubMed, RCAAP and SciELO. Articles, dissertations and theses published in Portuguese, English and Spanish were included, totalling 31 studies published from 1992 to 2013. This analysis resulted in four categories: ethical problems in the relationship between team members, ethical problems in the relationship with the user, ethical problems in health services management and resources for coping with ethical problems. Results showed that nurses need to be prepared to face ethical problems, emphasizing the importance of ethics education during the education process before and during professional practice to enhance the development of ethical sensitivity and competence for problem resolution.

  18. ALICE Connex : Mobile Volunteer Computing and Edutainment Platform

    CERN Document Server

    Chalumporn, Gantaphon

    2016-01-01

    Mobile devices are very powerful and trend to be developed. They have functions that are used in everyday life. One of their main tasks is to be an entertainment devices or gaming platform. A lot of technologies are now accepted and adopted to improve the potential of education. Edutainment is a combination of entertainment and education media together to make use of both benefits. In this work, we introduce a design of edutainment platform which is a part of mobile volunteer computing and edutainment platform called ‘ALICE Connex’ for ALICE at CERN. The edutainment platform focuses to deliver enjoyment and education, while promotes ALICE and Volunteer Computing platform to general public. The design in this work describes the functionality to build an effective edutainment with real-time multiplayer interaction on round-based gameplay, while integrates seamless edutainment with basic particle physic content though game mechanism and items design. For the assessment method we will observe the enjoyment o...

  19. A Novel Optical Sensor Platform Designed for Wireless Sensor Networks

    International Nuclear Information System (INIS)

    Yang, Shuo; Zhou, Bochao; Sun, Tong; Grattan, Kenneth T V

    2013-01-01

    This paper presents a novel design of an optical sensor platform, enabling effective integration of a number of optical fibre ('wired') sensors with wireless sensor networks (WSNs). In this work, a fibre Bragg grating-based temperature sensor with low power consumption is specially designed as a sensing module and integrated successfully into a WSN, making full use of the advantages arising from both the advanced optical sensor designs and the powerful network functionalities resident in WSNs. The platform is expected to make an important impact on many applications, where either the conventional optical sensor designs or WSNs alone cannot meet the requirements.

  20. Transmission problem for the Laplace equation and the integral equation method

    Czech Academy of Sciences Publication Activity Database

    Medková, Dagmar

    2012-01-01

    Roč. 387, č. 2 (2012), s. 837-843 ISSN 0022-247X Institutional research plan: CEZ:AV0Z10190503 Keywords : transmission problem * Laplace equation * boundary integral equation Subject RIV: BA - General Mathematics Impact factor: 1.050, year: 2012 http://www.sciencedirect.com/science/article/pii/S0022247X11008985

  1. Enhancing Trusted Cloud Computing Platform for Infrastructure as a Service

    Directory of Open Access Journals (Sweden)

    KIM, H.

    2017-02-01

    Full Text Available The characteristics of cloud computing including on-demand self-service, resource pooling, and rapid elasticity have made it grow in popularity. However, security concerns still obstruct widespread adoption of cloud computing in the industry. Especially, security risks related to virtual machine make cloud users worry about exposure of their private data in IaaS environment. In this paper, we propose an enhanced trusted cloud computing platform to provide confidentiality and integrity of the user's data and computation. The presented platform provides secure and efficient virtual machine management protocols not only to protect against eavesdropping and tampering during transfer but also to guarantee the virtual machine is hosted only on the trusted cloud nodes against inside attackers. The protocols utilize both symmetric key operations and public key operations together with efficient node authentication model, hence both the computational cost for cryptographic operations and the communication steps are significantly reduced. As a result, the simulation shows the performance of the proposed platform is approximately doubled compared to the previous platforms. The proposed platform eliminates cloud users' worry above by providing confidentiality and integrity of their private data with better performance, and thus it contributes to wider industry adoption of cloud computing.

  2. SysBioCube: A Data Warehouse and Integrative Data Analysis Platform Facilitating Systems Biology Studies of Disorders of Military Relevance.

    Science.gov (United States)

    Chowbina, Sudhir; Hammamieh, Rasha; Kumar, Raina; Chakraborty, Nabarun; Yang, Ruoting; Mudunuri, Uma; Jett, Marti; Palma, Joseph M; Stephens, Robert

    2013-01-01

    SysBioCube is an integrated data warehouse and analysis platform for experimental data relating to diseases of military relevance developed for the US Army Medical Research and Materiel Command Systems Biology Enterprise (SBE). It brings together, under a single database environment, pathophysio-, psychological, molecular and biochemical data from mouse models of post-traumatic stress disorder and (pre-) clinical data from human PTSD patients.. SysBioCube will organize, centralize and normalize this data and provide an access portal for subsequent analysis to the SBE. It provides new or expanded browsing, querying and visualization to provide better understanding of the systems biology of PTSD, all brought about through the integrated environment. We employ Oracle database technology to store the data using an integrated hierarchical database schema design. The web interface provides researchers with systematic information and option to interrogate the profiles of pan-omics component across different data types, experimental designs and other covariates.

  3. Integrated assignment and path planning

    Science.gov (United States)

    Murphey, Robert A.

    2005-11-01

    A surge of interest in unmanned systems has exposed many new and challenging research problems across many fields of engineering and mathematics. These systems have the potential of transforming our society by replacing dangerous and dirty jobs with networks of moving machines. This vision is fundamentally separate from the modern view of robotics in that sophisticated behavior is realizable not by increasing individual vehicle complexity, but instead through collaborative teaming that relies on collective perception, abstraction, decision making, and manipulation. Obvious examples where collective robotics will make an impact include planetary exploration, space structure assembly, remote and undersea mining, hazardous material handling and clean-up, and search and rescue. Nonetheless, the phenomenon driving this technology trend is the increasing reliance of the US military on unmanned vehicles, specifically, aircraft. Only a few years ago, following years of resistance to the use of unmanned systems, the military and civilian leadership in the United States reversed itself and have recently demonstrated surprisingly broad acceptance of increasingly pervasive use of unmanned platforms in defense surveillance, and even attack. However, as rapidly as unmanned systems have gained acceptance, the defense research community has discovered the technical pitfalls that lie ahead, especially for operating collective groups of unmanned platforms. A great deal of talent and energy has been devoted to solving these technical problems, which tend to fall into two categories: resource allocation of vehicles to objectives, and path planning of vehicle trajectories. An extensive amount of research has been conducted in each direction, yet, surprisingly, very little work has considered the integrated problem of assignment and path planning. This dissertation presents a framework for studying integrated assignment and path planning and then moves on to suggest an exact

  4. Integrating CLIPS applications into heterogeneous distributed systems

    Science.gov (United States)

    Adler, Richard M.

    1991-01-01

    SOCIAL is an advanced, object-oriented development tool for integrating intelligent and conventional applications across heterogeneous hardware and software platforms. SOCIAL defines a family of 'wrapper' objects called agents, which incorporate predefined capabilities for distributed communication and control. Developers embed applications within agents and establish interactions between distributed agents via non-intrusive message-based interfaces. This paper describes a predefined SOCIAL agent that is specialized for integrating C Language Integrated Production System (CLIPS)-based applications. The agent's high-level Application Programming Interface supports bidirectional flow of data, knowledge, and commands to other agents, enabling CLIPS applications to initiate interactions autonomously, and respond to requests and results from heterogeneous remote systems. The design and operation of CLIPS agents are illustrated with two distributed applications that integrate CLIPS-based expert systems with other intelligent systems for isolating and mapping problems in the Space Shuttle Launch Processing System at the NASA Kennedy Space Center.

  5. Enterprise Application Integration Using Java Technologies

    Directory of Open Access Journals (Sweden)

    Alexandru BARBULESCU

    2006-01-01

    Full Text Available The current article points out some of the tasks and challenges companies must face in order to integrate their computerized systems and applications and then to place them on the Web. Also, the article shows how the Java 2 Enterprise Edition Platform and architecture helps the Web integration of applications. By offering standardized integration contracts, J2EE Platform allows application servers to play a key role in the process of Web integration of the applications.

  6. Optical Beam Deflection Based AFM with Integrated Hardware and Software Platform for an Undergraduate Engineering Laboratory

    Directory of Open Access Journals (Sweden)

    Siu Hong Loh

    2017-02-01

    Full Text Available Atomic force microscopy (AFM has been used extensively in nanoscience research since its invention. Recently, many teaching laboratories in colleges, undergraduate institutions, and even high schools incorporate AFM as an effective teaching tool for nanoscience education. This paper presents an optical beam deflection (OBD based atomic force microscope, designed specifically for the undergraduate engineering laboratory as a teaching instrument. An electronic module for signal conditioning was built with components that are commonly available in an undergraduate electronic laboratory. In addition to off-the-shelf mechanical parts and optics, the design of custom-built mechanical parts waskept as simple as possible. Hence, the overall cost for the setup is greatly reduced. The AFM controller was developed using National Instruments Educational Laboratory Virtual Instrumentation Suite (NI ELVIS, an integrated hardware and software platform which can be programmed in LabVIEW. A simple yet effective control algorithm for scanning and feedback control was developed. Despite the use of an educational platform and low-cost components from the undergraduate laboratory, the developed AFM is capable of performing imaging in constant-force mode with submicron resolution and at reasonable scanning speed (approximately 18 min per image. Therefore, the AFM is suitable to be used as an educational tool for nanoscience. Moreover, the construction of the system can be a valuable educational experience for electronic and mechanical engineering students.

  7. Setting and solving several factorization problems for integral operators

    International Nuclear Information System (INIS)

    Engibaryan, N B

    2000-01-01

    The problem of factorization I-K=(I-U - )(I-U + ), is considered. Here I is the identity operator, K is a fixed integral operator of Fredholm type: (Kf)(x)=∫ a b k(x,t)f(t)dt, -∞≤a ± are unknown upper and lower Volterra operators. Classes of generalized Volterra operators U ± are introduced such that I-U ± are not necessarily invertible operators in the spaces of functions on (a,b) under consideration. A combination of the method of non-linear factorization equations and a priori estimates brings forth new results on the existence and properties of the solution to this problem for k≥0, both in the subcritical case μ + and U - vanish on some parts S - and S + of the domain S=(a,b) 2 such that S + union S - =S

  8. Service platform for rapid development and deployment of context-Aware, mobile applications

    NARCIS (Netherlands)

    Pokraev, S.; Koolwaaij, Johan; van Setten, Mark; Broens, Tom; Dockhorn Costa, Patrícia; Wibbels, Martin; Ebben, Peter; Strating, Patrick

    2005-01-01

    In this paper we present a web services-based platform that facilitates and speeds up the development and deployment of context-aware, integrated mobile speech and data applications. The platform is capable of handling different types of context and offers sophisticated personalization mechanisms.

  9. Scaffolding Teachers Integrate Social Media into a Problem-Based Learning Approach?

    Science.gov (United States)

    Buus, Lillian

    2012-01-01

    At Aalborg University (AAU) we are known to work with problem-based learning (PBL) in a particular way designated "The Aalborg PBL model." In PBL the focus is on participant control, knowledge sharing, collaboration among participants, which makes it interesting to consider the integration of social media in the learning that takes…

  10. Vibration Isolation and Trajectory Following Control of a Cable Suspended Stewart Platform

    Directory of Open Access Journals (Sweden)

    Xuechao Duan

    2016-10-01

    Full Text Available To achieve high-quality vibration isolation and trajectory following control of a cable driven parallel robot based Stewart platform in the five hundred meter aperture spherical radio telescope (FAST design, the integrated dynamic model of the Stewart platform including the electric cylinder is established in this paper, the globally feedback linearization of the dynamic model is implemented based on the control law partitioning approach. To overcome the disadvantages of the external disturbance on the base and unmodeled flexibility of the mechanism, a PID (Proportional-Derivative-Integral controller with base acceleration feedforward is designed in the operational space of the Stewart platform. Experiments of the vibration isolation and trajectory following control of the cable suspended Stewart platform with presence of the base disturbance is carried out. The experimental results show that the presented control scheme has the advantage of stable dynamics, high accuracy and strong robustness.

  11. Interoperability of remote handling control system software modules at Divertor Test Platform 2 using middleware

    Energy Technology Data Exchange (ETDEWEB)

    Tuominen, Janne, E-mail: janne.m.tuominen@tut.fi [Tampere University of Technology, Department of Intelligent Hydraulics and Automation, Tampere (Finland); Rasi, Teemu; Mattila, Jouni [Tampere University of Technology, Department of Intelligent Hydraulics and Automation, Tampere (Finland); Siuko, Mikko [VTT, Technical Research Centre of Finland, Tampere (Finland); Esque, Salvador [F4E, Fusion for Energy, Torres Diagonal Litoral B3, Josep Pla2, 08019, Barcelona (Spain); Hamilton, David [ITER Organization, Route de Vinon sur Verdon, 13115 Saint Paul Lez Durance (France)

    2013-10-15

    Highlights: ► The prototype DTP2 remote handling control system is a heterogeneous collection of subsystems, each realizing a functional area of responsibility. ► Middleware provides well-known, reusable solutions to problems, such as heterogeneity, interoperability, security and dependability. ► A middleware solution was selected and integrated with the DTP2 RH control system. The middleware was successfully used to integrate all relevant subsystems and functionality was demonstrated. -- Abstract: This paper focuses on the inter-subsystem communication channels in a prototype distributed remote handling control system at Divertor Test Platform 2 (DTP2). The subsystems are responsible for specific tasks and, over the years, their development has been carried out using various platforms and programming languages. The communication channels between subsystems have different priorities, e.g. very high messaging rate and deterministic timing or high reliability in terms of individual messages. Generally, a control system's communication infrastructure should provide interoperability, scalability, performance and maintainability. An attractive approach to accomplish this is to use a standardized and proven middleware implementation. The selection of a middleware can have a major cost impact in future integration efforts. In this paper we present development done at DTP2 using the Object Management Group's (OMG) standard specification for Data Distribution Service (DDS) for ensuring communications interoperability. DDS has gained a stable foothold especially in the military field. It lacks a centralized broker, thereby avoiding a single-point-of-failure. It also includes an extensive set of Quality of Service (QoS) policies. The standard defines a platform- and programming language independent model and an interoperability wire protocol that enables DDS vendor interoperability, allowing software developers to avoid vendor lock-in situations.

  12. An Experimental Study of an Offshore Platform

    DEFF Research Database (Denmark)

    Brincker, Rune; Asmussen, John Christian; Andersen, Palle

    of the multi-pile offshore platform is investigated by using a vibration based damage detection scheme. Changes in structural integrity are assumed to be reflected in the modal parameters estimated from only output data using an Auto-Regressive Moving Average (ARMA) model. Before the calibration of the ARMA...... model the quality of the measured data have been investigated. The estimated modal parameters and their corresponding variances are used as input to a probability based damage indicator. This indicator indicates, that since the construction of the platform, minor structural changes have taken place....

  13. Professional Cross-Platform Mobile Development in C#

    CERN Document Server

    Olson, Scott; Horgen, Ben; Goers, Kenny

    2012-01-01

    Develop mobile enterprise applications in a language you already know! With employees, rather than the IT department, now driving the decision of which devices to use on the job, many companies are scrambling to integrate enterprise applications. Fortunately, enterprise developers can now create apps for all major mobile devices using C#/.NET and Mono, languages most already know. A team of authors draws on their vast experiences to teach you how to create cross-platform mobile applications, while delivering the same functionality to PC's, laptops and the web from a single technology platform

  14. Problems in education, employment and social integration of hard of hearing artists

    Directory of Open Access Journals (Sweden)

    Radić-Šestić Marina

    2013-01-01

    Full Text Available The aim of this research was to determine the problems in education (primary, secondary and undergraduate academic studies, employment and social integration of hard of hearing artists based on a multiple case study. The sample consisted of 4 examinees of both genders, aged between 29 and 54, from the field of visual arts (a painter, a sculptor, a graphic designer, and an interior designer. The structured interview consisted of 30 questions testing three areas: the first area involved family, primary and secondary education; the second area was about the length of studying and socio-emotional problems of the examinees; the third area dealt with problems in employment and job satisfaction of our examinees. Research results indicate the existence of several problems which more or less reflect the success in education, employment and social integration of hard of hearing artists. One of the problems which can influence the development of language abilities, socioemotional maturity, and better educational achievement of hard of hearing artists in general, is prolongation in diagnosing hearing impairments, amplification and auditory rehabilitation. Furthermore, parents of hard of hearing artists have difficulties in adjusting to their children's hearing impairments and ignore the language and culture of the Deaf, i.e. they tend to identify their children with typically developing population. Another problem are negative attitudes of teachers/professors/employers and typically developing peers/ colleagues towards the inclusion of hard of hearing people into the regular education/employment system. Apart from that, unmodified instruction, course books, information, school and working area further complicate the acquisition of knowledge, information, and the progress of hard of hearing people in education and profession.

  15. The development and implementation of MOSAIQ Integration Platform (MIP) based on the radiotherapy workflow

    Science.gov (United States)

    Yang, Xin; He, Zhen-yu; Jiang, Xiao-bo; Lin, Mao-sheng; Zhong, Ning-shan; Hu, Jiang; Qi, Zhen-yu; Bao, Yong; Li, Qiao-qiao; Li, Bao-yue; Hu, Lian-ying; Lin, Cheng-guang; Gao, Yuan-hong; Liu, Hui; Huang, Xiao-yan; Deng, Xiao-wu; Xia, Yun-fei; Liu, Meng-zhong; Sun, Ying

    2017-03-01

    To meet the special demands in China and the particular needs for the radiotherapy department, a MOSAIQ Integration Platform CHN (MIP) based on the workflow of radiation therapy (RT) has been developed, as a supplement system to the Elekta MOSAIQ. The MIP adopts C/S (client-server) structure mode, and its database is based on the Treatment Planning System (TPS) and MOSAIQ SQL Server 2008, running on the hospital local network. Five network servers, as a core hardware, supply data storage and network service based on the cloud services. The core software, using C# programming language, is developed based on Microsoft Visual Studio Platform. The MIP server could offer network service, including entry, query, statistics and print information for about 200 workstations at the same time. The MIP was implemented in the past one and a half years, and some practical patient-oriented functions were developed. And now the MIP is almost covering the whole workflow of radiation therapy. There are 15 function modules, such as: Notice, Appointment, Billing, Document Management (application/execution), System Management, and so on. By June of 2016, recorded data in the MIP are as following: 13546 patients, 13533 plan application, 15475 RT records, 14656 RT summaries, 567048 billing records and 506612 workload records, etc. The MIP based on the RT workflow has been successfully developed and clinically implemented with real-time performance, data security, stable operation. And it is demonstrated to be user-friendly and is proven to significantly improve the efficiency of the department. It is a key to facilitate the information sharing and department management. More functions can be added or modified for further enhancement its potentials in research and clinical practice.

  16. Development of fast wireless detection system for fixed offshore platform

    Science.gov (United States)

    Li, Zhigang; Yu, Yan; Jiao, Dong; Wang, Jie; Li, Zhirui; Ou, Jinping

    2011-04-01

    Offshore platforms' security is concerned since in 1950s and 1960s, and in the early 1980s some important specifications and standards are built, and all these provide technical basis of fixed platform design, construction, installation and evaluation. With the condition that more and more platforms are in serving over age, the research about the evaluation and detection technology of offshore platform has been a hotspot, especially underwater detection, and assessment method based on the finite element calculation. For fixed platform structure detection, conventional NDT methods, such as eddy current, magnetic powder, permeate, X-ray and ultrasonic, etc, are generally used. These techniques are more mature, intuitive, but underwater detection needs underwater robot, the necessary supporting tools of auxiliary equipment, and trained professional team, thus resources and cost used are considerable, installation time of test equipment is long. This project presents a new kind of fast wireless detection and damage diagnosis system for fixed offshore platform using wireless sensor networks, that is, wireless sensor nodes can be put quickly on the offshore platform, detect offshore platform structure global status by wireless communication, and then make diagnosis. This system is operated simply, suitable for offshore platform integrity states rapid assessment. The designed system consists in intelligence acquisition equipment and 8 wireless collection nodes, the whole system has 64 collection channels, namely every wireless collection node has eight 16-bit accuracy of A/D channels. Wireless collection node, integrated with vibration sensing unit, embedded low-power micro-processing unit, wireless transceiver unit, large-capacity power unit, and GPS time synchronization unit, can finish the functions such as vibration data collection, initial analysis, data storage, data wireless transmission. Intelligence acquisition equipment, integrated with high

  17. Integrated reconfigurable multiple-input–multiple-output antenna system with an ultra-wideband sensing antenna for cognitive radio platforms

    KAUST Repository

    Hussain, Rifaqat

    2015-06-18

    © The Institution of Engineering and Technology 2015. A compact, novel multi-mode, multi-band frequency reconfigurable multiple-input-multiple-output (MIMO) antenna system, integrated with ultra-wideband (UWB) sensing antenna, is presented. The developed model can be used as a complete antenna platform for cognitive radio applications. The antenna system is developed on a single substrate area of dimensions 65 × 120 mm2. The proposed sensing antenna is used to cover a wide range of frequency bands from 710 to 3600 MHz. The frequency reconfigurable dual-element MIMO antenna is integrated with P-type, intrinsic, N-type (PIN) diodes for frequency agility. Different modes of selection are used for the MIMO antenna system reconfigurability to support different wireless system standards. The proposed MIMO antenna configuration is used to cover various frequency bands from 755 to 3450 MHz. The complete system comprising the multi-band reconfigurable MIMO antennas and UWB sensing antenna for cognitive radio applications is proposed with a compact form factor.

  18. High-Speed Solution of Spacecraft Trajectory Problems Using Taylor Series Integration

    Science.gov (United States)

    Scott, James R.; Martini, Michael C.

    2010-01-01

    It has been known for some time that Taylor series (TS) integration is among the most efficient and accurate numerical methods in solving differential equations. However, the full benefit of the method has yet to be realized in calculating spacecraft trajectories, for two main reasons. First, most applications of Taylor series to trajectory propagation have focused on relatively simple problems of orbital motion or on specific problems and have not provided general applicability. Second, applications that have been more general have required use of a preprocessor, which inevitably imposes constraints on computational efficiency. The latter approach includes the work of Berryman et al., who solved the planetary n-body problem with relativistic effects. Their work specifically noted the computational inefficiencies arising from use of a preprocessor and pointed out the potential benefit of manually coding derivative routines. In this Engineering Note, we report on a systematic effort to directly implement Taylor series integration in an operational trajectory propagation code: the Spacecraft N-Body Analysis Program (SNAP). The present Taylor series implementation is unique in that it applies to spacecraft virtually anywhere in the solar system and can be used interchangeably with another integration method. SNAP is a high-fidelity trajectory propagator that includes force models for central body gravitation with N X N harmonics, other body gravitation with N X N harmonics, solar radiation pressure, atmospheric drag (for Earth orbits), and spacecraft thrusting (including shadowing). The governing equations are solved using an eighth-order Runge-Kutta Fehlberg (RKF) single-step method with variable step size control. In the present effort, TS is implemented by way of highly integrated subroutines that can be used interchangeably with RKF. This makes it possible to turn TS on or off during various phases of a mission. Current TS force models include central body

  19. Digital coal mine integrated automation system based on Controlnet

    Energy Technology Data Exchange (ETDEWEB)

    Jin-yun Chen; Shen Zhang; Wei-ran Zuo [China University of Mining and Technology, Xuzhou (China). School of Chemical Engineering and Technology

    2007-06-15

    A three-layer model for digital communication in a mine is proposed. Two basic platforms are discussed: a uniform transmission network and a uniform data warehouse. An actual, ControlNet based, transmission network platform suitable for the Jining No.3 coal mine in China is presented. This network is an information superhighway intended to integrate all existing and new automation subsystems. Its standard interface can be used with future subsystems. The network, data structure and management decision-making all employ this uniform hardware and software. This effectively avoids the problems of system and information islands seen in traditional mine-automation systems. The construction of the network provides a stable foundation for digital communication in the Jining No.3 coal mine. 9 refs., 5 figs.

  20. Bringing eCare platforms to the market.

    Science.gov (United States)

    Vannieuwenborg, Frederic; Van der Auwermeulen, Thomas; Van Ooteghem, Jan; Jacobs, An; Verbugge, Sofie; Colle, Didier

    2017-09-01

    Due to changes in the demographic situation of most Western European countries, interest in Information and Communication Technologies (ICT)-supported care services is growing fast. eCare services that foster better care information exchange, social involvement, lifestyle monitoring services, etc., offered via ICT platforms, integrated in the homes of the elderly are believed to be cost-effective. Additionally, they could lead to an increased quality of life of both care receiver and (in)formal caregiver. Currently, adoption and integration of these eCare platforms (eCPs) is slowed down by several barriers such as unclear added value, a lack of regulations, or lack of sustainable financial models. In this work, the added value of eCPs is identified for the several involved key actors such as the care receiver, the (in)formal care providers, and the home care organizations. In a second step, several go-to-market strategies are formulated. Because the gap between the current way of providing home care and providing home care supported by a fully integrated eCP seems too big to bridge in one effort, a migration path is provided for stepwise integration and adoption of eCPs in the current way of home care provisioning.

  1. Enhancing creative problem solving in an integrated visual art and geometry program: A pilot study

    NARCIS (Netherlands)

    Schoevers, E.M.; Kroesbergen, E.H.; Pitta-Pantazi, D.

    2017-01-01

    This article describes a new pedagogical method, an integrated visual art and geometry program, which has the aim to increase primary school students' creative problem solving and geometrical ability. This paper presents the rationale for integrating visual art and geometry education. Furthermore

  2. Lessons Learned from Implementing National Nuclear Safety Knowledge Platforms

    International Nuclear Information System (INIS)

    Simo, A.

    2016-01-01

    The Integrated Nuclear Security Advisory Services (INSServ) took place in Cameroon from 21st to 25th April 2014 and the Integrated Regulatory Review Service (IRRS) from 12th to 21st October 2014. This was after the government requested the Director General of International Atomic Energy Agency (IAEA) through an official correspondence on 11th June 2013, for these missions. The main objective was to further improve the effectiveness of the Cameroon governmental, legal and regulatory framework for safety and security. Revision of the legal and regulatory framework so that all international safety and security standards are addressed in laws and statutes have been done with documents downloaded from Nuclear portal sites found in GNSSN. Establishment and implementation of integrated management systems by NRPA is being done with documentation under the National Nuclear Portal with lessons learned from the IAEA review missions. The regulatory documents have been uploaded on the platform and can be accessed through FNRBA and NRPA website (www.anrp.cm). UN organizations implementing projects in Cameroon are also linked to the platform. The action plans and progress reports for IAEA/AFRA projects are also available. Moreover, NRPA regulatory activities and licensing sources are available on this platform.

  3. Monitoring and Detection Platform to Prevent Anomalous Situations in Home Care

    Directory of Open Access Journals (Sweden)

    Gabriel Villarrubia

    2014-06-01

    Full Text Available Monitoring and tracking people at home usually requires high cost hardware installations, which implies they are not affordable in many situations. This study/paper proposes a monitoring and tracking system for people with medical problems. A virtual organization of agents based on the PANGEA platform, which allows the easy integration of different devices, was created for this study. In this case, a virtual organization was implemented to track and monitor patients carrying a Holter monitor. The system includes the hardware and software required to perform: ECG measurements, monitoring through accelerometers and WiFi networks. Furthermore, the use of interactive television can moderate interactivity with the user. The system makes it possible to merge the information and facilitates patient tracking efficiently with low cost.

  4. Discussion on several geological problems and uranium metallogeny on northern border of northern China block (platform)

    International Nuclear Information System (INIS)

    Chen Hong.

    1987-01-01

    According to the informations from the satellite image and the field investigation the following geological events on the northern border of the Northern China Block are recognized and confirmed, duch as suture zones between blocks, folding-reversed fault zones, back-arc collision zones (faulted zones), transitional zone between platform and geosyncline, magmatic are and the double sturcture composed of NNE trend magmatic active belt and fault-depression belts (basins) of Yenshan-Ximalaya age. On thsee bases the following problems, such as the unique structural environment of uranium mineralization related to abyssal magmatic rocks and Yenshan magmatic active zone (including volcanic belt) on the northern border of the Northern China Block, the metallogenetic modes for urnaium deposits of 'magmatic type' and 'neutralized surface type' in fault-depression zone and the classification of uranium metallogenetic belts and the criteria for such classification are studied and discussed. Several uranium deposits are given for illustrations

  5. Distributed hash table theory, platforms and applications

    CERN Document Server

    Zhang, Hao; Xie, Haiyong; Yu, Nenghai

    2013-01-01

    This SpringerBrief summarizes the development of Distributed Hash Table in both academic and industrial fields. It covers the main theory, platforms and applications of this key part in distributed systems and applications, especially in large-scale distributed environments. The authors teach the principles of several popular DHT platforms that can solve practical problems such as load balance, multiple replicas, consistency and latency. They also propose DHT-based applications including multicast, anycast, distributed file systems, search, storage, content delivery network, file sharing and c

  6. Analysis of offshore platforms lifting with fixed pile structure type (fixed platform) based on ASD89

    Science.gov (United States)

    Sugianto, Agus; Indriani, Andi Marini

    2017-11-01

    Platform construction GTS (Gathering Testing Sattelite) is offshore construction platform with fix pile structure type/fixed platform functioning to support the mining of petroleum exploitation. After construction fabrication process platform was moved to barges, then shipped to the installation site. Moving process is generally done by pull or push based on construction design determined when planning. But at the time of lifting equipment/cranes available in the work area then the moving process can be done by lifting so that moving activity can be implemented more quickly of work. This analysis moving process of GTS platform in a different way that is generally done to GTS platform types by lifting using problem is construction reinforcement required, so the construction can be moved by lifting with analyzing and checking structure working stress that occurs due to construction moving process by lifting AISC code standard and analysis using the SAP2000 structure analysis program. The analysis result showed that existing condition cannot be moved by lifting because stress ratio is above maximum allowable value that is 0.950 (AISC-ASD89). Overstress occurs on the member 295 and 324 with stress ratio value 0.97 and 0.95 so that it is required structural reinforcement. Box plate aplication at both members so that it produces stress ratio values 0.78 at the member 295 and stress ratio of 0.77 at the member 324. These results indicate that the construction have qualified structural reinforcement for being moved by lifting.

  7. A contact-force regulated photoplethysmography (PPG) platform

    Science.gov (United States)

    Sim, Jai Kyoung; Ahn, Bongyoung; Doh, Il

    2018-04-01

    A photoplethysmography (PPG) platform integrated with a miniaturized force-regulator is proposed in this study. Because a thermo-pneumatic type regulator maintains a consistent contact-force between the PPG probe and the measuring site, a consistent and stable PPG signal can be obtained. We designed and fabricated a watch-type PPG platform with an overall size of 35 mm × 19 mm. In the PPG measurement on the radial artery wrist while posture of the wrist is changed to extension, neutral, or flexion, regulation of the contact-force provides consistent PPG measurements for which the variations in the PPG amplitude (PPGA) was 7.2 %. The proposed PPG platform can be applied to biosignal measurements in various fields such as PPG-based ANS monitoring to estimate nociception, sleep apnea syndrome, and psychological stress.

  8. A contact-force regulated photoplethysmography (PPG platform

    Directory of Open Access Journals (Sweden)

    Jai Kyoung Sim

    2018-04-01

    Full Text Available A photoplethysmography (PPG platform integrated with a miniaturized force-regulator is proposed in this study. Because a thermo-pneumatic type regulator maintains a consistent contact-force between the PPG probe and the measuring site, a consistent and stable PPG signal can be obtained. We designed and fabricated a watch-type PPG platform with an overall size of 35 mm × 19 mm. In the PPG measurement on the radial artery wrist while posture of the wrist is changed to extension, neutral, or flexion, regulation of the contact-force provides consistent PPG measurements for which the variations in the PPG amplitude (PPGA was 7.2 %. The proposed PPG platform can be applied to biosignal measurements in various fields such as PPG-based ANS monitoring to estimate nociception, sleep apnea syndrome, and psychological stress.

  9. Co-simulation Platform for Train-to-Ground communications

    DEFF Research Database (Denmark)

    Yan, Ying; Bouaziz, Maha; Kassab, Mohamed

    The project SAFE4RAIL (SAFE architecture for Robust distributed Application Integration in roLling stock) from the Shift2Rail Joint Undertaking will provide a cosimulation platform based on hardware/software co-simulation. The platform will be used for Train-to-Ground (T2G) test environments...... in the context of the validation of the new wireless Train Control Management System (TCMS) transmission over LTE technologies in order to evaluate performances with realistic services and under various railway traffic conditions....

  10. An Integrative Clinical Database and Diagnostics Platform for Biomarker Identification and Analysis in Ion Mobility Spectra of Human Exhaled Air

    Directory of Open Access Journals (Sweden)

    Schneider Till

    2013-06-01

    Full Text Available Over the last decade the evaluation of odors and vapors in human breath has gained more and more attention, particularly in the diagnostics of pulmonary diseases. Ion mobility spectrometry coupled with multi-capillary columns (MCC/IMS, is a well known technology for detecting volatile organic compounds (VOCs in air. It is a comparatively inexpensive, non-invasive, high-throughput method, which is able to handle the moisture that comes with human exhaled air, and allows for characterizing of VOCs in very low concentrations. To identify discriminating compounds as biomarkers, it is necessary to have a clear understanding of the detailed composition of human breath. Therefore, in addition to the clinical studies, there is a need for a flexible and comprehensive centralized data repository, which is capable of gathering all kinds of related information. Moreover, there is a demand for automated data integration and semi-automated data analysis, in particular with regard to the rapid data accumulation, emerging from the high-throughput nature of the MCC/IMS technology. Here, we present a comprehensive database application and analysis platform, which combines metabolic maps with heterogeneous biomedical data in a well-structured manner. The design of the database is based on a hybrid of the entity-attribute- value (EAV model and the EAV-CR, which incorporates the concepts of classes and relationships. Additionally it offers an intuitive user interface that provides easy and quick access to the platform’s functionality: automated data integration and integrity validation, versioning and roll-back strategy, data retrieval as well as semi-automatic data mining and machine learning capabilities. The platform will support MCC/IMS-based biomarker identification and validation. The software, schemata, data sets and further information is publicly available at http://imsdb.mpi-inf.mpg.de.

  11. Reconfigurable, Intelligently-Adaptive, Communication System, an SDR Platform

    Science.gov (United States)

    Roche, Rigoberto J.; Shalkhauser, Mary Jo; Hickey, Joseph P.; Briones, Janette C.

    2016-01-01

    The Space Telecommunications Radio System (STRS) provides a common, consistent framework to abstract the application software from the radio platform hardware. STRS aims to reduce the cost and risk of using complex, configurable and reprogrammable radio systems across NASA missions. The NASA Glenn Research Center (GRC) team made a software defined radio (SDR) platform STRS compliant by adding an STRS operating environment and a field programmable gate array (FPGA) wrapper, capable of implementing each of the platforms interfaces, as well as a test waveform to exercise those interfaces. This effort serves to provide a framework toward waveform development onto an STRS compliant platform to support future space communication systems for advanced exploration missions. The use of validated STRS compliant applications provides tested code with extensive documentation to potentially reduce risk, cost and e ort in development of space-deployable SDRs. This paper discusses the advantages of STRS, the integration of STRS onto a Reconfigurable, Intelligently-Adaptive, Communication System (RIACS) SDR platform, and the test waveform and wrapper development e orts. The paper emphasizes the infusion of the STRS Architecture onto the RIACS platform for potential use in next generation flight system SDRs for advanced exploration missions.

  12. Human health impacts for renewable energy scenarios from the EnerGEO Platform of Integrated Assessment (PIA)

    International Nuclear Information System (INIS)

    Lefevre, Mireille; Gschwind, Benoit; Blanc, Isabelle; Ranchin, Thierry; Cofala, Janusz; Fuss, Sabine

    2013-01-01

    This article reports impact results from running the EnerGEO Platform of Integrated Assessment (PIA) related to human health for different scenarios in Europe. The scenarios were prepared within the EnerGEO project. The idea of this European project is to determine how low carbon scenarios, and in particular scenarios with a high share of renewable energy, affect concentrations of air pollutants and as a consequence affect human health. PM 2.5 concentrations were estimated with the IIASA Greenhouse Gas and Air Pollution Interactions and Synergies (GAINS) model on a time horizon up to the year 2050 for different scenarios. We analyse here the estimation of the Loss of Life Expectancy due to PM 2.5 concentrations for the Baseline scenario taken as a reference and the Maximum renewable power scenario. (orig.)

  13. Opening the SMS platform to users : Deliverable D7.2 - RISIS project

    NARCIS (Netherlands)

    van den Besselaar, P.A.A.; Khalili, A.; de Graaf, K.A.; Idrissou, O.A.K.; van Harmelen, Frank

    2017-01-01

    In this deliverable we describe the SMS (Semantically Mapping Science) data integration platform (http://sms.risis.eu), the technical core within the RISIS data infrastructure for Science, Technology and Innovation Studies (STI). The aim of the platform is to produce richer data to be used in social

  14. Information security threats in web-portals on the open journal systems platform

    Directory of Open Access Journals (Sweden)

    Anton A. Abramov

    2018-05-01

    Full Text Available This article addresses the problem of security threats while working with web portals built on the Open Journal Systems platform. The Open Journal Systems (OJS platform was originally developed as part of the Public Knowledge Project and it is one of the most popular open-source platforms for web journals today. Based on the data available in the Public Knowledge Project, there were more than 10,000 active journals using the open journal systems platform by the end of 2016. A migration of a journal to such advanced and complex platform helps to handle the entire workflow over a single web portal. Therefore it is an important move and only peer-reviewed journals that are part of Russian and Worldwide citation systems go for it. At the same time the problem of keeping privacy for a manuscript before it is published is very important for these journals and for authors who submit it to the journal. The paper describes the most common threats for the web portals on the OJS platform as well as a particular model of the security threats, and suggests the measures that could help to neutralize these threats.

  15. Yeast surface display platform for rapid discovery of conformationally selective nanobodies

    DEFF Research Database (Denmark)

    McMahon, Conor; Baier, Alexander S.; Pascolutti, Roberta

    2018-01-01

    this problem, we report a fully in vitro platform for nanobody discovery based on yeast surface display. We provide a blueprint for identifying nanobodies, demonstrate the utility of the library by crystallizing a nanobody with its antigen, and most importantly, we utilize the platform to discover...... conformationally selective nanobodies to two distinct human GPCRs. To facilitate broad deployment of this platform, the library and associated protocols are freely available for nonprofit research....

  16. Collaborative Development Planning Model of Supporting Product in Platform Innovation Ecosystem

    OpenAIRE

    Wei Zhang; Hamid Reza Karimi; Qingpu Zhang; Shaobo Wu

    2014-01-01

    Published version of an article in the journal: Mathematical Problems in Engineering. Also available from the publisher at: http://10.1155/2014/690589 In order to improve the market value of the product, the platform enterprise often participates in the development process of supporting product of emerging industry's platform innovation ecosystem. This paper puts forward a revenue sharing contract between the platform company and the supporting company by creating a collaborative developme...

  17. Eradication of Productivity Related Problems Through Lean Principles In Integrated Manufacturing Environment

    Directory of Open Access Journals (Sweden)

    Rahul

    2013-06-01

    Full Text Available In this competitive era, manufacturing enterprises struggle to adopt cost-effective manufacturing systems. Overview of the recent manufacturing enterprises shows that successful global manufacturing enterprises have distributed their manufacturing capabilities over the globe. The successes of distributed integrated manufacturing enterprises depend upon the adaptation of appropriate manufacturing technologies like computer integrated manufacturing (CIM under the global collaborative environment along with the principles of lean manufacturing so that their corporate goals are achieved. CIM is an umbrella term which involves automated design, analysis, planning manufacturing, dispatching, customer-interaction, purchasing, cost accounting, inventory control and factory floor functions, which are inter-linked through the computer, to control all the campus-wide manufacturing related operations. It helps to improve the performance of a firm by integrating various areas of manufacturing business in which most of lean ideas are embedded. These lean ideas cause work in a process to be performed with minimum of non-value adding activities and focus on customers’ needs by delivering them at minimum time, with high quality and at minimum cost by eliminating hidden waste. What happens at the shop floor of even an integrated industry is that proper and timely attention is not paid to the intangible lean principles in the manual part of the CIM system which results in substantial loss of the plant productivity. Therefore the objective of this research paper is to investigate the different poor productivity-related problems in a partially integrated manufacturing environment and lay down the remedial measures to eradicate them using ‘Juran’s problem solving techniques’ and various ‘lean tools’ which results in the reduced wastages and hence improved productivity.

  18. High resolution data from everyday life: coproducing a technically robust and engaging sensing platform

    Directory of Open Access Journals (Sweden)

    Matthew Machin

    2017-04-01

    We found it was feasible to integrate requirements from both researchers and patients when developing a sensing platform for dementia research. By seeking feedback from both user groups, we were better able to attend to device linkage requirements, platform functionality and acceptability, integrating these within development and procurement processes. Furthermore, we identified aspects of research setup and design that could support sustained engagement from participants, thereby improving data completeness and quality.

  19. Improved Stewart platform state estimation using inertial and actuator position measurements

    NARCIS (Netherlands)

    MiletoviC, I.; Pool, D.M.; Stroosma, O.; van Paassen, M.M.; Chu, Q.

    2017-01-01

    Accurate and reliable estimation of the kinematic state of a six degrees-of-freedom Stewart platform is a problem of interest in various engineering disciplines. Particularly so in the area of flight simulation, where the Stewart platform is in widespread use for the generation of motion similar

  20. A Semantic Big Data Platform for Integrating Heterogeneous Wearable Data in Healthcare.

    Science.gov (United States)

    Mezghani, Emna; Exposito, Ernesto; Drira, Khalil; Da Silveira, Marcos; Pruski, Cédric

    2015-12-01

    Advances supported by emerging wearable technologies in healthcare promise patients a provision of high quality of care. Wearable computing systems represent one of the most thrust areas used to transform traditional healthcare systems into active systems able to continuously monitor and control the patients' health in order to manage their care at an early stage. However, their proliferation creates challenges related to data management and integration. The diversity and variety of wearable data related to healthcare, their huge volume and their distribution make data processing and analytics more difficult. In this paper, we propose a generic semantic big data architecture based on the "Knowledge as a Service" approach to cope with heterogeneity and scalability challenges. Our main contribution focuses on enriching the NIST Big Data model with semantics in order to smartly understand the collected data, and generate more accurate and valuable information by correlating scattered medical data stemming from multiple wearable devices or/and from other distributed data sources. We have implemented and evaluated a Wearable KaaS platform to smartly manage heterogeneous data coming from wearable devices in order to assist the physicians in supervising the patient health evolution and keep the patient up-to-date about his/her status.