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Sample records for platform definition study

  1. Geosynchronous platform definition study. Volume 6: Geosynchronous program evaluation and recommendations

    Science.gov (United States)

    Myers, H. L.

    1973-01-01

    The programmatic analyses conducted to achieve the objectives of the study are presented. The characteristics are examined of alternate geosynchronous programs based on servicing concepts, geosynchronous platform configurations, and equipment definitions which have evolved during the study. The logistics support necessary to carry out programs using these systems is defined considering alternate approaches for on-orbit servicing. The costs of the resultant programs are then determined and the alternate program approaches compared. Conventional programs with expendable satellites are also defined to the extent necessary to permit comparison with on-orbit serviced platform programs.

  2. Geosynchronous platform definition study. Volume 4, Part 1: Traffic analysis and system requirements for the baseline traffic model

    Science.gov (United States)

    1973-01-01

    The traffic analyses and system requirements data generated in the study resulted in the development of two traffic models; the baseline traffic model and the new traffic model. The baseline traffic model provides traceability between the numbers and types of geosynchronous missions considered in the study and the entire spectrum of missions foreseen in the total national space program. The information presented pertaining to the baseline traffic model includes: (1) definition of the baseline traffic model, including identification of specific geosynchronous missions and their payload delivery schedules through 1990; (2) Satellite location criteria, including the resulting distribution of the satellite population; (3) Geosynchronous orbit saturation analyses, including the effects of satellite physical proximity and potential electromagnetic interference; and (4) Platform system requirements analyses, including satellite and mission equipment descriptions, the options and limitations in grouping satellites, and on-orbit servicing criteria (both remotely controlled and man-attended).

  3. WhatisKT wiki: a case study of a platform for knowledge translation terms and definitions — descriptive analysis

    Directory of Open Access Journals (Sweden)

    McKibbon Kathleen Ann

    2013-01-01

    Full Text Available Abstract Background More than a hundred terms, often with unclear definitions and varying emphases, are used by health research and practice communities across the world who are interested in getting the best possible evidence applied (e.g., knowledge translation, implementation science, diffusion of innovations, and technology transfer. This makes finding published evidence difficult and can result in reduced, misinterpreted, or challenging interactions among professionals. Open dialogue and interaction among various professionals is needed to achieve consolidation of vocabulary. We use case report methods to describe how we sought to build an online tool to present the range of terms and facilitate the dialogue process across groups and disciplines interested in harnessing research evidence for healthcare. Methods We used a wiki platform from Wikispaces to present the problem of terminology and make a case and opportunity for collaboration on usage. Wikis are web sites where communities of users can collaborate online to build content and discuss progress. We gathered terms related to getting research into practice, sought published definitions, and posted these on the wiki (WhatisKT http://whatiskt.wikispaces.com/. We built the wiki in mid-2008 and promoted it through various groups and publications. This report describes the content of the site, our promotion efforts, use of the site, and how the site was used for collaboration up to the end of 2011. Results The WhatisKT wiki site now includes more than 120 pages. Traffic to the site has increased substantially from an average of 200 monthly visits in 2008 to 1700 in 2011. Visitors from 143 countries viewed the wiki in 2011, compared with 12 countries in 2008. However, most use has been limited to short term accesses of about 40 seconds per visit, and discussion of consolidation and solidifying terminology is conspicuously absent. Conclusions Although considerable interest exists in the

  4. The Definitive Guide to NetBeans™ Platform 7

    CERN Document Server

    Bock, Heiko

    2011-01-01

    The NetBeans Platform is the world's only modular Swing application framework, used by very large organizations in mission-critical scenarios, such as at Boeing and Northrop Grumman, as well as in the financial sector and in the oil/gas industry. For these large customers in enterprises who are increasingly interested in Maven and OSGi, the book will have particular relevance. The Definitive Guide to NetBeans Platform 7 is a thorough and authoritative introduction to the open-source NetBeans Platform, covering all its major APIs in detail, with relevant code examples used throughout. * Provide

  5. Geosynchronous platform definition study. Volume 4, Part 2: Traffic analysis and system requirements for the new traffic model

    Science.gov (United States)

    1973-01-01

    A condensed summary of the traffic analyses and systems requirements for the new traffic model is presented. The results of each study activity are explained, key analyses are described, and important results are highlighted.

  6. Platform evolution studies

    Science.gov (United States)

    Walton, Barbara A.

    1990-01-01

    The polar orbiting platform (POP), being developed by the Work Package 3 (WP3) Project at the Goddard Space Flight Center, will play a key role in the NASA Leadership Initiative, Mission to Planet Earth (MPE). It becomes, with the addition of payloads, an Earth observation satellite observatory. Mission to Planet Earth also has geostationary platforms (GEOP) as part of its global observational system. A study was begun in March 1988 to assess the applicability of the POP orbital replacement units (ORUs) for a geostationary Earth observing mission. Two test cases, representative of MPE payloads, were studied. Case A was used to emphasize the GEOP configuration and design; it used a Titan/Centaur to achieve orbit. Case B, considered to be much further in the future, included some assembly at the Space Station Freedom manned base and use of an orbital transfer vehicle to achieve orbit; requirements on the manned base to support such a mission were emphasized. The study found the POP systems more than adequate to meet GEOP requirements. Two types of changes were required for the POP ORUs: (1) modification to use only one surface for heat rejection; for the battery ORU, this meant 'opening up' the ORU to retain the radiator area with a corresponding decrease in depth; and (2) deletion of equipment not needed. The Case A configuration was shown to be within the planned capability of the Titan IV/Centaur. Assembly requirements were included for the Case B configuration, which is driven by the large microwave antennas of two of the payloads. The final review was April 19, 1989.

  7. The definitive guide to Jython Python for the Java platform

    CERN Document Server

    Juneau, Josh; Ng, Victor; Soto, Leo; Wierzbicki, Frank

    2010-01-01

    Jython is an open source implementation of the high-level, dynamic, object-oriented scripting language Python seamlessly integrated with the Java platform. The predecessor to Jython, JPython, is certified as 100% Pure Java. Jython is freely available for both commercial and noncommercial use and is distributed with source code. Jython is complementary to Java. The Definitive Guide to Jython, written by the official Jython team leads, covers the latest Jython 2.5 (or 2.5.x) from the basics to the advanced features. This book begins with a brief introduction to the language and then journeys thr

  8. Trust Levels Definition On Virtual Learning Platforms Through Semantic Languages

    Directory of Open Access Journals (Sweden)

    Carlos E. Montenegro-Marin

    2010-12-01

    Full Text Available Trust level concept is a topic that has opened a knowledge area about the profile evaluation and the people participation in Social Networks. These have presented a high knowledge profit, but at the same time it is necessary to analyze a group of variables to determine the trust participants’ degree.In addition, this is a topic that from some years ago has been presenting a big expectation to settle some alternatives to generate confidence in an activer community on internet. To establish these parameters it is important to define a model to abstract some variables that are involved in this process. For this, it is relevant to take into account the semantic languages as one of the alternatives that allow these kinds of activities. The purpose of this article is to analyze the Trust Levels definition in the contents that are shared on Open Source Virtual learning Platforms through the use of a model of representation of semantic languages. The last ones allow determining the trust in the use of learning objects that are shared in this kind of platforms

  9. Developing a service platform definition to promote evidence-based planning and funding of the mental health service system.

    Science.gov (United States)

    Lee, Yong Yi; Meurk, Carla S; Harris, Meredith G; Diminic, Sandra; Scheurer, Roman W; Whiteford, Harvey A

    2014-11-26

    Ensuring that a mental health system provides 'value for money' requires policy makers to allocate resources to the most cost-effective interventions. Organizing cost-effective interventions into a service delivery framework will require a concept that can guide the mapping of evidence regarding disorder-level interventions to aggregations of services that are meaningful for policy makers. The 'service platform' is an emerging concept that could be used to this end, however no explicit definition currently exists in the literature. The aim of this study was to develop a service platform definition that is consistent with how policy makers conceptualize the major elements of the mental health service system and to test the validity and utility of this definition through consultation with mental health policy makers. We derived a provisional definition informed by existing literature and consultation with experienced mental health researchers. Using a modified Delphi method, we obtained feedback from nine Australian policy makers. Respondents provided written answers to a questionnaire eliciting their views on the acceptability, comprehensibility and usefulness of a service platform definition which was subject to qualitative analysis. Overall, respondents understood the definition and found it both acceptable and useful, subject to certain conditions. They also provided suggestions for its improvement. Our findings suggest that the service platform concept could be a useful way of aggregating mental health services as a means for presenting priority setting evidence to policy makers in mental health. However, further development and testing of the concept is required.

  10. Definition Study PHARUS

    Science.gov (United States)

    1991-11-01

    definitie studie zijn gebruikt in het voorontwerp van het PHARUS systeem . TNO report STUDelft Page 6 ABSTRACT 3 SAMENVAlTING 4 CONTENTS 6 1 INTRODUCTION 9...University of Technology, Laboratory for Telecommunication and Remote Sensing Technology. FEL-TNO had tke lead and was responsible for the project management ...Aerospace Programs in Delft was responsible for the program management . The definition study PHARUS was started in the first half of 1988 and ended

  11. Developing a Service Platform Definition to Promote Evidence-Based Planning and Funding of the Mental Health Service System

    Directory of Open Access Journals (Sweden)

    Yong Yi Lee

    2014-11-01

    Full Text Available Ensuring that a mental health system provides ‘value for money’ requires policy makers to allocate resources to the most cost-effective interventions. Organizing cost-effective interventions into a service delivery framework will require a concept that can guide the mapping of evidence regarding disorder-level interventions to aggregations of services that are meaningful for policy makers. The ‘service platform’ is an emerging concept that could be used to this end, however no explicit definition currently exists in the literature. The aim of this study was to develop a service platform definition that is consistent with how policy makers conceptualize the major elements of the mental health service system and to test the validity and utility of this definition through consultation with mental health policy makers. We derived a provisional definition informed by existing literature and consultation with experienced mental health researchers. Using a modified Delphi method, we obtained feedback from nine Australian policy makers. Respondents provided written answers to a questionnaire eliciting their views on the acceptability, comprehensibility and usefulness of a service platform definition which was subject to qualitative analysis. Overall, respondents understood the definition and found it both acceptable and useful, subject to certain conditions. They also provided suggestions for its improvement. Our findings suggest that the service platform concept could be a useful way of aggregating mental health services as a means for presenting priority setting evidence to policy makers in mental health. However, further development and testing of the concept is required.

  12. Study on Collision Characters for SPAR Platform

    Institute of Scientific and Technical Information of China (English)

    HU Zhi-qiang; CUI Wei-cheng

    2008-01-01

    This paper presents the research on the external mechanism of collision characters for a SPAR platform. The collision characters of SPAR platform have not attracted so much attention as that of ships in the past, because short of this kind of collision accidents reported. But with the increasing number of SPAR platforms in the world, the possibility of such kind of accident also increases. Therefore, it is necessary to master the character of SPAR collision. Model test technique is employed to study the external mechanism. The collision scenario is a ship colliding with a SPAR platform moored in the site with 1500 meters water depth. The striking ship hits the SPAR platform on the hard tank near water surface in its longitudinal direction. The specifics of the SPAR's motions and the tension forces of the mooring lines are collected to summarize the hydrodynamic characters in the collision scenario. It is found that the maximal displacements and the maximal pitch angles of the SPAR platform, and the maximal tension forces of mooring lines are all linearly proportional to the initial velocity of the striking ship basically. Mooring lines play elastic roles in the collision course.

  13. Implementing Product Platforms: A Case Study

    DEFF Research Database (Denmark)

    Nielsen, Ole Fiil; Mortensen, Niels Henrik

    2006-01-01

    The paper describes a case study dealing with the process of creating and implementing a product platform. The paper espessially deals with the fact that to obtain the benefits of platforms a permanent change in behaviour in product development must be ensured. This change in behaviour requires...... acceptance and approval from the organisation in general and the commitment from management to enforce agreed-upon decisions. The case study itself was performed in the Danish company LEGO Group. The case study had two objectives: To create a technical architecture and align this architecture...

  14. Developing a service platform definition to promote evidence-based planning and funding of the mental health service system

    National Research Council Canada - National Science Library

    Lee, Yong Yi; Meurk, Carla S; Harris, Meredith G; Diminic, Sandra; Scheurer, Roman W; Whiteford, Harvey A

    2014-01-01

    ... of services that are meaningful for policy makers. The 'service platform' is an emerging concept that could be used to this end, however no explicit definition currently exists in the literature...

  15. Virtual interconnection platform initiative scoping study

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Yong [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Kou, Gefei [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Pan, Zuohong [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Liu, Yilu [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); King Jr., Thomas J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2016-01-01

    Due to security and liability concerns, the research community has limited access to realistic large-scale power grid models to test and validate new operation and control methodologies. It is also difficult for industry to evaluate the relative value of competing new tools without a common platform for comparison. This report proposes to develop a large-scale virtual power grid model that retains basic features and represents future trends of major U.S. electric interconnections. This model will include realistic power flow and dynamics information as well as a relevant geospatial distribution of assets. This model will be made widely available to the research community for various power system stability and control studies and can be used as a common platform for comparing the efficacies of various new technologies.

  16. Microfluidic platforms for plant cells studies.

    Science.gov (United States)

    Sanati Nezhad, A

    2014-09-07

    Conventional methods of plant cell analysis rely on growing plant cells in soil pots or agarose plates, followed by screening the plant phenotypes in traditional greenhouses and growth chambers. These methods are usually costly, need a large number of experiments, suffer from low spatial resolution and disorderly growth behavior of plant cells, with lack of ability to locally and accurately manipulate the plant cells. Microfluidic platforms take advantage of miniaturization for handling small volume of liquids and providing a closed environment, with the purpose of in vitro single cell analysis and characterizing cell response to external cues. These platforms have shown their ability for high-throughput cellular analysis with increased accuracy of experiments, reduced cost and experimental times, versatility in design, ability for large-scale and combinatorial screening, and integration with other miniaturized sensors. Despite extensive research on animal cells within microfluidic environments for high-throughput sorting, manipulation and phenotyping studies, the application of microfluidics for plant cells studies has not been accomplished yet. Novel devices such as RootChip, RootArray, TipChip, and PlantChip developed for plant cells analysis, with high spatial resolution on a micrometer scale mimicking the internal microenvironment of plant cells, offering preliminary results on the capability of microfluidics to conquer the constraints of conventional methods. These devices have been used to study different aspects of plant cell biology such as gene expression, cell biomechanics, cellular mechanism of growth, cell division, and cells fusion. This review emphasizes the advantages of current microfluidic systems for plant science studies, and discusses future prospects of microfluidic platforms for characterizing plant cells response to diverse external cues.

  17. Model refinement for offshore platforms: Experimental study

    Science.gov (United States)

    Zhang, Min; Chen, Zongli; Wu, Yanjian

    2017-08-01

    Offshore jacket platforms are widely used in offshore oil and gas exploitation. Finite element models of such structures need to have many degrees of freedom (DOFs) to represent the geometrical detail of complex structures, thereby leading to incompatibility in the number of DOFs of experimental models. To bring them both to the same order while ensuring that the essential eigen- properties of the refined model match those of experimental models, an extended model refinement procedure is presented in this paper. Vibration testing of an offshore jacket platform model is performed to validate the applicability of the proposed approach. A full-order finite element model of the platform is established and then tuned to meet the measured modal properties identified from the acceleration signals. Both model reduction and modal expansion methods are investigated, as well as various scenarios of sensor arrangements. Upon completion of the refinement, the updated jacket platform model matches the natural frequencies of the measured model well.

  18. STUDY OF VARIOUS INTERNET OF THINGS PLATFORMS

    Directory of Open Access Journals (Sweden)

    Bhumi Nakhuva

    2015-12-01

    Full Text Available Internet of Things is a technological revolution which provides the vision of connected world of Things. Devices, people and systems are connected with one another in such a way that they can communicate with each other over Internet. So the form of communication from human-human is now turned into humanhuman, human-things and things- things. Variety of platforms are now a days available that can support entire development to deployment of IoT applications and systems. In this paper, we will first start with the introduction of IoT platforms as well as IoT middleware and then will discuss various IoT platforms, compare various IoT platforms and will end up with the conclusion.

  19. An Experimental Study of an Offshore Platform

    DEFF Research Database (Denmark)

    Brincker, Rune; Asmussen, John Christian; Andersen, Palle

    This report describes the results of an analysis of the ambient response data collected from a Venezuelan near-shore offshore platform constructed in 1992. Recording of the data have been constantly done during the period from May 1993 to July 1994. Using these data the structural integrity...... of the multi-pile offshore platform is investigated by using a vibration based damage detection scheme. Changes in structural integrity are assumed to be reflected in the modal parameters estimated from only output data using an Auto-Regressive Moving Average (ARMA) model. Before the calibration of the ARMA...... model the quality of the measured data have been investigated. The estimated modal parameters and their corresponding variances are used as input to a probability based damage indicator. This indicator indicates, that since the construction of the platform, minor structural changes have taken place....

  20. Development of a Novel Microfluidic Platform for Multiple Sclerosis Study

    Science.gov (United States)

    2012-08-01

    Platform for Multiple Sclerosis Study PRINCIPAL INVESTIGATOR: In Hong Yang CONTRACTING ORGANIZATION: Johns Hopkins University...COVERED 15 Jul 2011 - 14 Jul 2012 4. TITLE AND SUBTITLE Development of a Novel Microfluidic Platform for Multiple Sclerosis Study 5a. CONTRACT NUMBER...NSC in the pathology and therapy of neurodegenerative disorders including multiple sclerosis (MS) [1-2]. Evidence suggests that NSC proliferation

  1. Evaluation of E-learning Platforms: a Case Study

    Directory of Open Access Journals (Sweden)

    Cristina POP

    2012-01-01

    Full Text Available In the recent past, a great number of e-learning platforms have been introduced on the market showing different characteristics and services. These platforms can be evaluated using multiple criteria and methods. This paper proposes a list of selected quality criteria for describing, characterizing and selecting e-learning platform. These criteria were designed based on e-learning standards. I also propose a mathematical model to determine the probability that a student uses an e-learning platform based on the factors (criteria that determine the quality of the platform and the socio-demographic variables of the student. The case study presented is an application of the model and the input data, intermediate calculations and final results were processed using SAS (Statistical Analysis Software.

  2. A Study of the Simulation Platform of WCDMA

    Institute of Scientific and Technical Information of China (English)

    ZHU Song-jian; SONG Mei; REN Li-gang; SONG Jun-de

    2004-01-01

    In this paper, we present a new simulation platform of 3G (the third-generation mobile communication). Combined with the concept of Software Defined Radio (SDR) and complied with the 3rd Generation Partnership Project (3GPP) proposal, first, we build up a general structure platform of the downlink physical layer based on 3G WCDMA (FDD) in COSSAP software package, then study such key technology of 3G as turbo encoders and decoders, RAKE receivers. The simulation result is similar to relevant documents. As a result, it could be applied as a basic platform to do further research on the key technology in SDR field.

  3. Operating an Advertising Programmatic Buying Platform: A Case Study

    Directory of Open Access Journals (Sweden)

    Juan Carlos Gonzalvez-Cabañas

    2016-03-01

    Full Text Available This paper analyses how new technological developments and the possibilities generated by the internet are shaping the online advertising market. More specifically it focuses on a programmatic advertising case study. The origin of the problem is how publishers resort to automated buying and selling when trying to shift unsold inventory. To carry out our case study, we will use a programmatic online advertising sales platform, which identifies the optimal way of promoting a given product. The platform executes, evaluates, manages and optimizes display advertising campaigns, all in real-time. The empirical analysis carried out in the case study reveals that the platform and its exclusion algorithms are suitable mechanisms for analysing the performance and efficiency of the various segments that might be used to promote products. Thanks to Big Data tools and artificial intelligence the platform performs automatically, providing information in a user-friendly and simple manner.

  4. Stability Study of Cable-Suspended Stewart Platform

    Institute of Scientific and Technical Information of China (English)

    GAO Yan-kun; CHENG Yuan; REN Ge-xue; HUANG De-xiu

    2008-01-01

    The control stability of the end manipulator of a cable-suspended Stewart platform in disturbance was studied by combination of the multi-body system dynamics and control theory and the eigensystem realization algorithm (ERA). The corresponding closed-loop vibration control strategies were suggested based on position prediction with PD (proportional plus derivative) control.Numerical simulation was made on a scale model to study the vibration control effects of the stewart platform with flexible suspension, including system response to step load, system response to cyclic load, and instability. Then, experiments for Stewart platform with cable suspension were designed to study the actual control effects and validate the validity of numerical simulation. The results show that the experimental results agree with the simulation results well, and the the system has a fairly good control effect to the end manipulator. Therefore, a preliminary conclusion can be made that it is feasible using the Stewart platform as the vibration control platform of the flexible support system, by position prediction of the base platform and PD feedback control law.

  5. ICT platform for support AC circuits study

    OpenAIRE

    Moisés Luis San Martín Ojeda; Eduardo Pedro Parra Gonzalo; Moisés Blanco Caballero; Alberto Sánchez Lite; Jose Andrés Serrano Sanz; Maria Isabel Jiménez Gómez; Manuel García García

    2014-01-01

    [EN] The software used for making educational tools allows analyze the engineering phenomena in a more complete and explained way, by means of simulation and experimentation. It is necessary to know the equations about the behaviour of the object under study for the generation of these tools, and to solve them through the right software, obtaining the output values from the input values. With this software it is possible to realize new studies only modifying the parameters of the ...

  6. Alternative Future Fleet Platform Architecture Study

    Science.gov (United States)

    2016-10-27

    1067 of the National Defense Authorization Act for Fiscal Year 2016 (Appendix 1) directed the Secretary of Defense to conduct three independent studies... Secretary of Defense, the Naval Surface Warfare Center, Dahlgren Division, the Naval Postgraduate School, the U.S. Naval War College, the Center for...this leadership role , the Navy Project Team identified the key missions for the U.S. Navy: - protecting the homeland - building security globally

  7. Electromagnetic levitation platform for wireless study of insect flight neurophysiology.

    Science.gov (United States)

    Verderber, Alexander; McKnight, Michael; Bozkurt, Alper

    2013-01-01

    An electromagnetic levitation platform for use in a light emitting diode (LED) arena based virtual reality environment was developed for wireless recording of neural and neuromuscular signals from the flight related muscle groups in Manduca sexta. The platform incorporates the use of Early Metamorphosis Insertion Technology to implant recording electrodes into the flight muscles of late stage pupal moths. Analysis of the insects' response to changes in the LED arena rotation direction indicate that this setup could be used to perform a variety of flight behavior studies during yaw maneuvers.

  8. A Shared Platform for Studying Second Language Acquisition

    Science.gov (United States)

    MacWhinney, Brian

    2017-01-01

    The study of second language acquisition (SLA) can benefit from the same process of datasharing that has proven effective in areas such as first language acquisition and aphasiology. Researchers can work together to construct a shared platform that combines data from spoken and written corpora, online tutors, and Web-based experimentation. Many of…

  9. Kajian Teknologi High Altitude Platform (HAP [Study of High Altitude Platform (HAP Technology

    Directory of Open Access Journals (Sweden)

    Amry Daulat Gultom

    2016-07-01

    Full Text Available High Altitude Platform (HAP merupakan solusi alternatif untuk mengatasi keterbatasan infrastruktur terestrial maupun satelit. HAP merupakan pesawat ataupun balon udara yang ditempatkan pada ketinggian 20-50 km di atas permukaan bumi. Kelebihan yang utama dari HAP adalah kemudahan dalam penempatan, fleksibilitas, biaya operasionalnya rendah, delay  propagasi rendah, sudut elevasi lebar, cakupan yang luas. Penelitian ini dilakukan untuk mengetahui potensi HAP untuk komunikasi pita lebar dan perkembangannya di Indonesia. Analisis dilakukan secara deskriptif dengan mengolah data literatur yang didapat. Hasil penelitian menunjukkan bahwa di Indonesia terdapat potensi teknologi HAP untuk komunikasi pita lebar dengan lebar pita 2x300 MHz di band 27,9-28,2 GHz dan 31-31,3 GHz. Namun, belum ada peraturan yang mengatur alokasi frekuensi untuk HAP secara khusus di Indonesia.*****High Altitude Platform (HAP has been developed as an alternative solution in order to overcome limitation of terrestrial and satellite communication system. HAP is an aircraft or balloon situated on 20-50 km above the earth. Main advantages of HAP are flexibility in deployment, low propagation delay, wide elevation angle and broad coverage. The research is conducted to gather HAP potential for broadband communication and its development in Indonesia. Analysis is conducted by descriptive analysis from literature study gather. The research result shows that in Indonesia, there is potential of HAP technology for broadband communication with 2x300 MHz bandwidth within 27,9-28,2 GHz and 31-31,3 GHz. Yet, there are no specific regulations managing frequency allocation for HAP in Indonesia.

  10. Platform for dynamic tests: preliminary studies, design and construction

    Directory of Open Access Journals (Sweden)

    J. E. Campuzano

    Full Text Available This paper is about the design and construction of a platform for dynamic tests especially with people jumping, walking, etc. Initially it was tried to find out projects already implemented in platforms and dynamic tests and to study the loads produced by movement of people on slabs and the structural response to these loads. The limits established by different standards have been also studied for these dynamic responses, taking into account the ultimate limit state, as well as the structure in service, since the human body is very sensitive to structural vibrations. Parametric studies were performed considering various configurations of slabs (different spans, thicknesses and conditions of support have been done, looking for a configuration that could have natural frequency close to the frequencies of the human loads. The slab should have dimensions compatible with the available physical space, fundamental frequency below 5 Hz and maximum immediate deflection compatible with the indications of the Brazilian standard NBR6118: 2007. Based on these criteria was chosen a rectangular structure consists of a solid reinforced concrete rectangular slab studded in two opposite edges of steel beams with shear connectors type U. The other two edges are free. The steel beams supporting the slab, in turn, are supported on eight metal profiles (two in each corner of the slab that are supported on two to two short columns of steel profile H. Profiles U in steel are welded to four columns, forming a horizontal frame. Numerical analysis of the dynamic test platform have been performed for free and forced vibration, for obtaining the natural frequencies and corresponding vibration modes, considering the self-weight of the structure and the load that simulates people's weight. After obtaining a structural configuration that fulfilled the stipulated requirements, the design of the slab taking into account the recommendations of the Brazilian standard NBR6118: 2007

  11. Overview of aerothermodynamic loads definition study

    Science.gov (United States)

    Gaugler, Raymond E.

    1991-01-01

    The objective of the Aerothermodynamic Loads Definition Study is to develop methods of accurately predicting the operating environment in advanced Earth-to-Orbit (ETO) propulsion systems, such as the Space Shuttle Main Engine (SSME) powerhead. Development of time averaged and time dependent three dimensional viscous computer codes as well as experimental verification and engine diagnostic testing are considered to be essential in achieving that objective. Time-averaged, nonsteady, and transient operating loads must all be well defined in order to accurately predict powerhead life. Described here is work in unsteady heat flow analysis, improved modeling of preburner flow, turbulence modeling for turbomachinery, computation of three dimensional flow with heat transfer, and unsteady viscous multi-blade row turbine analysis.

  12. A Comparative Study on Hardware Platforms for Wireless Sensor Networks

    Directory of Open Access Journals (Sweden)

    Thang Vu Chien

    2012-01-01

    Full Text Available Recently, Wireless Sensor Networks (WSNs attract a great deal of research attention, and are envisioned to support a variety of applications, including building monitoring, environment control, wild-life habitat monitoring, forest fire detection, industry automation, military, security, and health-care. Over the years, we have seen a variety of hardware platforms for WSNs to facilitate developing WSN applications. In this paper, we provide a comprehensive review of existing hardware platforms for WSNs. We first present the hardware architecture of a wireless sensor node. We then survey the major hardware platforms for WSNs and present a comparison of these hardware platforms. Finally we present some recommendations from the perspectives of hardware platform developers and hardware platform users. The authors hope that making information about existing hardware platforms will assist researchers working in this area to appreciate the diversity of platforms available to them and to help them select the most appropriate platform for their purposes.

  13. Digital questionnaire platform in the Danish Blood Donor Study

    DEFF Research Database (Denmark)

    Burgdorf, K S; Felsted, N; Mikkelsen, S

    2016-01-01

    OBJECTIVES: The Danish Blood Donor Study (DBDS) is a prospective, population-based study and biobank. Since 2010, 100,000 Danish blood donors have been included in the study. Prior to July 2015 all participating donors had to complete a paper-based questionnaire. Here we describe the establishment...... with the questionnaire data in the DBDS database. RESULTS: The digital platform enables personalized questionnaires, presenting only questions relevant to the specific donor by hiding unneeded follow-up questions on screening question results. New versions of questionnaires are immediately available at all blood...

  14. Product platform life cycles : a multiple case study

    NARCIS (Netherlands)

    Wortmann, Hans; Alblas, Alex

    2009-01-01

    Product platforms are used to specify a (virtual) company's offering to the market in terms of functionality and performance. The specification covers a rang e of actual products and services and the platform includes choice features, options and external interfaces. Usually, the platform also

  15. Product platform life cycles : a multiple case study

    NARCIS (Netherlands)

    Wortmann, Hans; Alblas, Alex

    2009-01-01

    Product platforms are used to specify a (virtual) company's offering to the market in terms of functionality and performance. The specification covers a rang e of actual products and services and the platform includes choice features, options and external interfaces. Usually, the platform also speci

  16. Definition study for photovoltaic residential prototype system

    Science.gov (United States)

    Imamura, M. S.; Hulstrom, R. L.; Cookson, C.; Waldman, B. H.; Lane, R. A.

    1976-01-01

    A parametric sensitivity study and definition of the conceptual design is presented. A computer program containing the solar irradiance, solar array, and energy balance models was developed to determine the sensitivities of solar insolation and the corresponding solar array output at five sites selected for this study as well as the performance of several solar array/battery systems. A baseline electrical configuration was chosen, and three design options were recommended. The study indicates that the most sensitive parameters are the solar insolation and the inverter efficiency. The baseline PST selected is comprised of a 133 sg m solar array, 250 ampere hour battery, one to three inverters, and a full shunt regulator to limit the upper solar array voltage. A minicomputer controlled system is recommended to provide the overall control, display, and data acquisition requirements. Architectural renderings of two photovoltaic residential concepts, one above ground and the other underground, are presented. The institutional problems were defined in the areas of legal liabilities during and after installation of the PST, labor practices, building restrictions and architectural guides, and land use.

  17. Study on Building Lifecycle Information Management Platform Based on BIM

    Directory of Open Access Journals (Sweden)

    Wang-Jian Ping

    2014-01-01

    Full Text Available Building Information Modeling (BIM and building lifecycle management (BLM, proposed for the realization of building lifecycle information exchange and sharing, play a crucial role in the research and development fields of construction information integration and interoperability. This study, from an information technology point of view, based on BLM and BIM technology and Industry Foundation Classes (IFC standard, proposes the concept, frame and realization method of Building Lifecycle Management Platform (BLMP. This BLMP presents a practical and effective way to realize information creating, exchange, sharing and integration management of all participants of the construction project.

  18. GESDB: a platform of simulation resources for genetic epidemiology studies.

    Science.gov (United States)

    Yao, Po-Ju; Chung, Ren-Hua

    2016-01-01

    Computer simulations are routinely conducted to evaluate new statistical methods, to compare the properties among different methods, and to mimic the observed data in genetic epidemiology studies. Conducting simulation studies can become a complicated task as several challenges can occur, such as the selection of an appropriate simulation tool and the specification of parameters in the simulation model. Although abundant simulated data have been generated for human genetic research, currently there is no public database designed specifically as a repository for these simulated data. With the lack of such a database, for similar studies, similar simulations may have been repeated, which resulted in redundant work. Thus, we created an online platform, the Genetic Epidemiology Simulation Database (GESDB), for simulation data sharing and discussion of simulation techniques for genetic epidemiology studies. GESDB consists of a database for storing simulation scripts, simulated data and documentation from published articles as well as a discussion forum, which provides a platform for discussion of the simulated data and exchanging simulation ideas. Moreover, summary statistics such as the simulation tools that are most commonly used and datasets that are most frequently downloaded are provided. The statistics will be informative for researchers to choose an appropriate simulation tool or select a common dataset for method comparisons. GESDB can be accessed at http://gesdb.nhri.org.twDatabase URL: http://gesdb.nhri.org.tw.

  19. Lessons learned: Transfer of the high-definition circulating tumor cell assay platform to development as a commercialized clinical assay platform.

    Science.gov (United States)

    Kuhn, P; Keating, S M; Baxter, G T; Thomas, K; Kolatkar, A; Sigman, C C

    2017-02-04

    Planning and transfer of a new technology platform developed in an academic setting to a start-up company for medical diagnostic product development may appear daunting and costly in terms of complexity, time, and resources. In this review we outline the key steps taken and lessons learned when a technology platform developed in an academic setting was transferred to a start-up company for medical diagnostic product development in the interest of elucidating development toolkits for academic groups and small start-up companies starting on the path to commercialization and regulatory approval.

  20. National Biomedical Tracer Facility: Project definition study

    Energy Technology Data Exchange (ETDEWEB)

    Heaton, R.; Peterson, E. [Los Alamos National Lab., NM (United States); Smith, P. [Smith (P.A.) Concepts and Designs (United States)

    1995-05-31

    The Los Alamos National Laboratory is an ideal institution and New Mexico is an ideal location for siting the National Biomedical Tracer Facility (NBTF). The essence of the Los Alamos proposal is the development of two complementary irradiation facilities that combined with our existing radiochemical processing hot cell facilities and waste handling and disposal facilities provide a low cost alternative to other proposals that seek to satisfy the objectives of the NBTF. We propose the construction of a 30 MeV cyclotron facility at the site of the radiochemical facilities, and the construction of a 100 MeV target station at LAMPF to satisfy the requirements and objectives of the NBTF. We do not require any modifications to our existing radiochemical processing hot cell facilities or our waste treatment and disposal facilities to accomplish the objectives of the NBTF. The total capital cost for the facility defined by the project definition study is $15.2 M. This cost estimate includes $9.9 M for the cyclotron and associated facility, $2.0 M for the 100 MeV target station at LAMPF, and $3.3 M for design.

  1. Microfabricated platforms for the study of neuronal and cellular networks

    Energy Technology Data Exchange (ETDEWEB)

    Berdondini, L; Generelli, S; Kraus, T; Guenat, O T; Koster, S; Linder, V; Koudelka-Hep, M; Rooij, N F de [SAMLAB, Institute of Microtechnology, University of Neuchatel (Switzerland)

    2006-04-01

    In this contribution we present the development of three microfabricated devices for the study of neuronal and cellular networks. Together, these devices form an attractive toolbox, which is useful to stimulate and record signals of both electrical and chemical nature. One approach consist of microelectrode arrays for the study of neuronal networks, and allow for the electrical stimulation of individual cells in the network, while the other electrodes of the array record the electrical activity of the remaining cells of the network. We also present the use of micropipettes that can measure the extra- and intracellular concentrations of ions in cells cultures. A third approach exploits the laminar flows in a microfluidic device, to deliver minute amounts of drug to some cells in a cellular network. These three illustrations show that microfabricated platforms are appealing analytical tools in the context of cell biology.

  2. Study of Piezoresistive Micro Electro-Mechanical Accelerometer Design Platform

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    According to the inland micro electro-mechanical system (MEMS) process technique level, a design platform of piezoresistive micro electro-mechanical accelerometer is given. This platform is much more adaptable to the inland designer compared with the current MEMS CAD software. The design flow is presented in detail, and the key techique in the platform is analyzed amply. The structure design methodology is exemplified in the design of a piezoresistive accelerometer, and the accelerometer is the optimized structure for the given performance requirements. The accelerometer is now being manufactured.

  3. Platform Constellations

    DEFF Research Database (Denmark)

    Staykova, Kalina Stefanova; Damsgaard, Jan

    2016-01-01

    This research paper presents an initial attempt to introduce and explain the emergence of new phenomenon, which we refer to as platform constellations. Functioning as highly modular systems, the platform constellations are collections of highly connected platforms which co-exist in parallel...... and as such allow us to study platforms not only as separate entities, but also to investigate the relationship between several platforms offered and governed by one and the same platform provider. By investigating two case studies of indigenous platform constellations formed around the hugely popular instant...... messaging apps KakaoTalk and LINE, we are able to gain valuable insights about the nature of these new constructions and to capture and synthesize their main characteristics in a framework. Our results show that platform constellations possess unique innovative capabilities, which can improve users...

  4. Optical microassembly platform for constructing reconfigurable microenvironment for biomedical studies

    DEFF Research Database (Denmark)

    Rodrigo, Peter John; Kelemen, Lóránd; Palima, Darwin

    2009-01-01

    Cellular development is highly influenced by the surrounding microenvironment. We propose user-reconfigurable microenvironments and bio-compatible scaffolds as an approach for understanding cellular development processes. We demonstrate a model platform for constructing versatile microenvironments...

  5. KinomeXplorer: an integrated platform for kinome biology studies

    DEFF Research Database (Denmark)

    Horn, Heiko; Schoof, Erwin; Kim, Jinho

    2014-01-01

    A letter to the editor is presented related to the KinomeXplorer, an integrated platform providing workflows to efficiently analyze phosphorylation dependent interaction networks or kinase signaling networks....

  6. A Study of Covert Communications in Space Platforms Hosting Government Payloads

    Science.gov (United States)

    2015-02-01

    NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA A STUDY OF COVERT COMMUNICATIONS IN SPACE PLATFORMS HOSTING GOVERNMENT PAYLOADS by Thuy D...COVERED (From-To) 4. TITLE AND SUBTITLE A STUDY OF COVERT COMMUNICATIONS IN SPACE PLATFORMS HOSTING GOVERNMENT PAYLOADS 5a. CONTRACT NUMBER 5b. GRANT...access to space by hosting government-supplied payloads on commercial space platforms. These commercially hosted payloads require stringent

  7. How Digital Publishing Combined With Printed Books: A Case Study of The Jinglun Digital Publishing Platform

    OpenAIRE

    Zhang, Xia

    2015-01-01

    The purpose of this study was to provide insights into the digital publishing market in China and Canada through case studies on the Jinglun Digital Publishing Platform. The retrieved data shows that there is opportunity of establishing a new digital publishing platform in Canada. The analysis of Jinglun Digital Publishing Platform showed that we can use the digital content add to the user experience of reading on digital publishing, but the mainstream position of print books is unshakable. T...

  8. Development of a Modular Research Platform to Create Medical Observational Studies for Mobile Devices.

    Science.gov (United States)

    Zens, Martin; Grotejohann, Birgit; Tassoni, Adrian; Duttenhoefer, Fabian; Südkamp, Norbert P; Niemeyer, Philipp

    2017-05-23

    Observational studies have proven to be a valuable resource in medical research, especially when performed on a large scale. Recently, mobile device-based observational studies have been discovered by an increasing number of researchers as a promising new source of information. However, the development and deployment of app-based studies is not trivial and requires profound programming skills. The aim of this project was to develop a modular online research platform that allows researchers to create medical studies for mobile devices without extensive programming skills. The platform approach for a modular research platform consists of three major components. A Web-based platform forms the researchers' main workplace. This platform communicates via a shared database with a platform independent mobile app. Furthermore, a separate Web-based login platform for physicians and other health care professionals is outlined and completes the concept. A prototype of the research platform has been developed and is currently in beta testing. Simple questionnaire studies can be created within minutes and published for testing purposes. Screenshots of an example study are provided, and the general working principle is displayed. In this project, we have created a basis for a novel research platform. The necessity and implications of a modular approach were displayed and an outline for future development given. International researchers are invited and encouraged to participate in this ongoing project.

  9. Tethered elevator and platforms as space station facilities: Systems studies and demonstrative experiments

    Science.gov (United States)

    1986-01-01

    Several key concepts of the science and applications tethered platforms were studied. Some conclusions reached are herein listed. Tether elevator and platform could improve the space station scientific and applicative capabilities. The space elevator presents unique characteristics as microgravity facility and as a tethered platform servicing vehicle. Pointing platforms could represent a new kind of observation facility for large class of payloads. The dynamical, control and technological complexity of these concepts advised demonstrative experiments. The on-going tethered satellite system offers the opportunity to perform such experiments. And feasibility studies are in progress.

  10. Cross-Platform Technologies

    Directory of Open Access Journals (Sweden)

    Maria Cristina ENACHE

    2017-04-01

    Full Text Available Cross-platform - a concept becoming increasingly used in recent years especially in the development of mobile apps, but this consistently over time and in the development of conventional desktop applications. The notion of cross-platform software (multi-platform or platform-independent refers to a software application that can run on more than one operating system or computing architecture. Thus, a cross-platform application can operate independent of software or hardware platform on which it is execute. As a generic definition presents a wide range of meanings for purposes of this paper we individualize this definition as follows: we will reduce the horizon of meaning and we use functionally following definition: a cross-platform application is a software application that can run on more than one operating system (desktop or mobile identical or in a similar way.

  11. TRUTH OR DARE: ONLINE DELIBERATION. A CASE STUDY OF TWO INTERNET BASED DELIBERATIVE PLATFORMS

    Directory of Open Access Journals (Sweden)

    Luana Maria BIDAȘCĂ

    2011-06-01

    Full Text Available In this article, I attempt to discuss how the internet can be used to stimulate an effective communication between citizens and decision-makers. In particular, I will aim to see if it can facilitate a greater degree of deliberation among citizens, if it can make democracy more inclusive and if it can make decision makers more responsible. I will first look at the definition and characteristics of deliberative democracy. Then after looking at what has been written so far about the effect of online discussions on democracy, I shall analyze the role the internet played in two case studies: web based participatory budgeting (PB and domnuleprimar.ro (DearMrMayor.ro. Both of these platforms were designed to create a closer bond between decisionmakers and citizens and will thus prove relevant to the discussion. Finally, I conclude that while the two case studies seem to favor increased inclusiveness, it only partially increases accountability and does not register any significant progress with regard to deliberation. Still, I argue that reasons for optimism exist even with regard to the deliberative aspect. Since the debate regarding the value of online deliberation is far from over, more research is needed in order to perhaps design a framework which will allow us to exploit the democratic value of the internet to its full potential.

  12. Design and Study of Cognitive Network Physical Layer Simulation Platform

    Directory of Open Access Journals (Sweden)

    Yongli An

    2014-01-01

    Full Text Available Cognitive radio technology has received wide attention for its ability to sense and use idle frequency. IEEE 802.22 WRAN, the first to follow the standard in cognitive radio technology, is featured by spectrum sensing and wireless data transmission. As far as wireless transmission is concerned, the availability and implementation of a mature and robust physical layer algorithm are essential to high performance. For the physical layer of WRAN using OFDMA technology, this paper proposes a synchronization algorithm and at the same time provides a public platform for the improvement and verification of that new algorithm. The simulation results show that the performance of the platform is highly close to the theoretical value.

  13. A study of inter-lab and inter-platform agreement of DNA microarray data

    Directory of Open Access Journals (Sweden)

    Wilson Carole

    2005-05-01

    Full Text Available Abstract As gene expression profile data from DNA microarrays accumulate rapidly, there is a natural need to compare data across labs and platforms. Comparisons of microarray data can be quite challenging due to data complexity and variability. Different labs may adopt different technology platforms. One may ask about the degree of agreement we can expect from different labs and different platforms. To address this question, we conducted a study of inter-lab and inter-platform agreement of microarray data across three platforms and three labs. The statistical measures of consistency and agreement used in this paper are the Pearson correlation, intraclass correlation, kappa coefficients, and a measure of intra-transcript correlation. The three platforms used in the present paper were Affymetrix GeneChip, custom cDNA arrays, and custom oligo arrays. Using the within-platform variability as a benchmark, we found that these technology platforms exhibited an acceptable level of agreement, but the agreement between two technologies within the same lab was greater than that between two labs using the same technology. The consistency of replicates in each experiment varies from lab to lab. When there is high consistency among replicates, different technologies show good agreement within and across labs using the same RNA samples. On the other hand, the lab effect, especially when confounded with the RNA sample effect, plays a bigger role than the platform effect on data agreement.

  14. Study on the application of mobile internet cloud computing platform

    Science.gov (United States)

    Gong, Songchun; Fu, Songyin; Chen, Zheng

    2012-04-01

    The innovative development of computer technology promotes the application of the cloud computing platform, which actually is the substitution and exchange of a sort of resource service models and meets the needs of users on the utilization of different resources after changes and adjustments of multiple aspects. "Cloud computing" owns advantages in many aspects which not merely reduce the difficulties to apply the operating system and also make it easy for users to search, acquire and process the resources. In accordance with this point, the author takes the management of digital libraries as the research focus in this paper, and analyzes the key technologies of the mobile internet cloud computing platform in the operation process. The popularization and promotion of computer technology drive people to create the digital library models, and its core idea is to strengthen the optimal management of the library resource information through computers and construct an inquiry and search platform with high performance, allowing the users to access to the necessary information resources at any time. However, the cloud computing is able to promote the computations within the computers to distribute in a large number of distributed computers, and hence implement the connection service of multiple computers. The digital libraries, as a typical representative of the applications of the cloud computing, can be used to carry out an analysis on the key technologies of the cloud computing.

  15. A study on an information security system of a regional collaborative medical platform.

    Science.gov (United States)

    Zhao, Junping; Peng, Kun; Leng, Jinchang; Sun, Xiaowei; Zhang, Zhenjiang; Xue, Wanguo; Ren, Lianzhong

    2010-01-01

    The objective of this study was to share the experience of building an information security system for a regional collaborative medical platform (RCMP) and discuss the lessons learned from practical projects. Safety measures are analyzed from the perspective of system engineering. We present the essential requirements, critical architectures, and policies for system security of regional collaborative medical platforms.

  16. OTEC platform configuration and integration study. Volume I. Systems engineering and integration. Final report

    Energy Technology Data Exchange (ETDEWEB)

    None

    1978-04-01

    The economic success of an Ocean Thermal Energy Conversion (OTEC) system is highly dependent on a platform which provides adequate support for the power system, accommodates reliably the cold water pipe, and is most cost effective. The results of a study conducted for the Department of Energy to assess six generic types of platforms to determine the most satisfactory platform for severl potential sites are presented. The six platform configurations are ship, circular barge, semi-submersible, Tuned Sphere, submersible, and spar. These represent directional and symmetric types of platforms which operate on the surface, at the interface, and submerged. The five sites for this study were primarily New Orleans, Keahole Point (Hawaii), Brazil, and secondarily Key West and Puerto Rico. Electrical transmission of energy by submarine cable is the planned form of energy transmission for all sites except Brazil, where chemical conversion is to be the method of transmission. This study is devoted to the platform (or ocean systems) of the OTEC plant which is chiefly comprised of the hull and structure, the seawater system, the position control system, and miscellaneous support/assembly systems. The principal elements in the work breakdown structure for the commercial plants are presented. The assessment of the six platform configurations was conducted utilizing a baseline plan (100-MW(e) (Net)) and site (New Orleans) with variations from the baseline to cover the range of interested platforms and sites.

  17. Mars power system concept definition study. Volume 1: Study results

    Science.gov (United States)

    Littman, Franklin D.

    1994-12-01

    A preliminary top level study was completed to define power system concepts applicable to Mars surface applications. This effort included definition of power system requirements and selection of power systems with the potential for high commonality. These power systems included dynamic isotope, Proton Exchange Membrane (PEM) regenerative fuel cell, sodium sulfur battery, photovoltaic, and reactor concepts. Design influencing factors were identified. Characterization studies were then done for each concept to determine system performance, size/volume, and mass. Operations studies were done to determine emplacement/deployment maintenance/servicing, and startup/shutdown requirements. Technology development roadmaps were written for each candidate power system (included in Volume 2). Example power system architectures were defined and compared on a mass basis. The dynamic isotope power system and nuclear reactor power system architectures had significantly lower total masses than the photovoltaic system architectures. Integrated development and deployment time phasing plans were completed for an example DIPS and reactor architecture option to determine the development strategies required to meet the mission scenario requirements.

  18. Toward a Definition of Study Abroad Success

    OpenAIRE

    Schnickel, Jacob

    2015-01-01

    This paper presents a rationale and method for collecting critical incidents from university students who have returned from studying abroad. There are three main benefits to this process. First, it appears beneficial for students to record and reflect on their experiences abroad. Second, a collection of critical incidents, through analysis, can yield patterns of student experiences that can, in turn, inform decision making about the study-abroad program at a given institution. Third, critica...

  19. Discursive Study of Religion : Approaches, Definitions, Implications

    NARCIS (Netherlands)

    von Stuckrad, Kocku

    2013-01-01

    The article explores recent approaches to historical analysis of discourse that have been developed in disciplines such as the sociology of knowledge and historical epistemology. These approaches have only sporadically been taken seriously in the academic study of religion, although they have a

  20. Discursive Study of Religion : Approaches, Definitions, Implications

    NARCIS (Netherlands)

    von Stuckrad, Kocku

    2013-01-01

    The article explores recent approaches to historical analysis of discourse that have been developed in disciplines such as the sociology of knowledge and historical epistemology. These approaches have only sporadically been taken seriously in the academic study of religion, although they have a grea

  1. Data Collection for Mental Health Studies Through Digital Platforms: Requirements and Design of a Prototype.

    Science.gov (United States)

    Aledavood, Talayeh; Triana Hoyos, Ana Maria; Alakörkkö, Tuomas; Kaski, Kimmo; Saramäki, Jari; Isometsä, Erkki; Darst, Richard K

    2017-06-09

    Mental and behavioral disorders are the main cause of disability worldwide. However, their diagnosis is challenging due to a lack of reliable biomarkers; current detection is based on structured clinical interviews which can be biased by the patient's recall ability, affective state, changing in temporal frames, etc. While digital platforms have been introduced as a possible solution to this complex problem, there is little evidence on the extent of usability and usefulness of these platforms. Therefore, more studies where digital data is collected in larger scales are needed to collect scientific evidence on the capacities of these platforms. Most of the existing platforms for digital psychiatry studies are designed as monolithic systems for a certain type of study; publications from these studies focus on their results, rather than the design features of the data collection platform. Inevitably, more tools and platforms will emerge in the near future to fulfill the need for digital data collection for psychiatry. Currently little knowledge is available from existing digital platforms for future data collection platforms to build upon. The objective of this work was to identify the most important features for designing a digital platform for data collection for mental health studies, and to demonstrate a prototype platform that we built based on these design features. We worked closely in a multidisciplinary collaboration with psychiatrists, software developers, and data scientists and identified the key features which could guarantee short-term and long-term stability and usefulness of the platform from the designing stage to data collection and analysis of collected data. The key design features that we identified were flexibility of access control, flexibility of data sources, and first-order privacy protection. We also designed the prototype platform Non-Intrusive Individual Monitoring Architecture (Niima), where we implemented these key design features. We

  2. Problem Definition Study: Lead Beta-Resorcylate

    Science.gov (United States)

    1979-02-01

    Otto Barlocher GmbH Metallgesellschaft AG ITALY Stabilital SpA Spain Industrias Quimicas de Parets. SA UNITED KINGDOM Akzo Chemie UK Ltd...appears to be the motor activity of the bowel. In his studies with human «subjects, Kehoe (1942) found nc effect of dietary changes in calcium or...increase in cerebrocortical acetylchollne and a decrease in brain stem noreplnephrine. The changes in the regional levels of these biogenlc amines

  3. Solar dynamic power system definition study

    Science.gov (United States)

    Wallin, Wayne E.; Friefeld, Jerry M.

    1988-01-01

    The solar dynamic power system design and analysis study compared Brayton, alkali-metal Rankine, and free-piston Stirling cycles with silicon planar and GaAs concentrator photovoltaic power systems for application to missions beyond the Phase 2 Space Station level of technology for all power systems. Conceptual designs for Brayton and Stirling power systems were developed for 35 kWe and 7 kWe power levels. All power systems were designed for 7-year end-of-life conditions in low Earth orbit. LiF was selected for thermal energy storage for the solar dynamic systems. Results indicate that the Stirling cycle systems have the highest performance (lowest weight and area) followed by the Brayton cycle, with photovoltaic systems considerably lower in performance. For example, based on the performance assumptions used, the planar silicon power system weight was 55 to 75 percent higher than for the Stirling system. A technology program was developed to address areas wherein significant performance improvements could be realized relative to the current state-of-the-art as represented by Space Station. In addition, a preliminary evaluation of hardenability potential found that solar dynamic systems can be hardened beyond the hardness inherent in the conceptual designs of this study.

  4. Genetic properties of the MAGIC maize population: a new platform for high definition QTL mapping in Zea mays.

    Science.gov (United States)

    Dell'Acqua, Matteo; Gatti, Daniel M; Pea, Giorgio; Cattonaro, Federica; Coppens, Frederik; Magris, Gabriele; Hlaing, Aye L; Aung, Htay H; Nelissen, Hilde; Baute, Joke; Frascaroli, Elisabetta; Churchill, Gary A; Inzé, Dirk; Morgante, Michele; Pè, Mario Enrico

    2015-09-11

    Maize (Zea mays) is a globally produced crop with broad genetic and phenotypic variation. New tools that improve our understanding of the genetic basis of quantitative traits are needed to guide predictive crop breeding. We have produced the first balanced multi-parental population in maize, a tool that provides high diversity and dense recombination events to allow routine quantitative trait loci (QTL) mapping in maize. We produced 1,636 MAGIC maize recombinant inbred lines derived from eight genetically diverse founder lines. The characterization of 529 MAGIC maize lines shows that the population is a balanced, evenly differentiated mosaic of the eight founders, with mapping power and resolution strengthened by high minor allele frequencies and a fast decay of linkage disequilibrium. We show how MAGIC maize may find strong candidate genes by incorporating genome sequencing and transcriptomics data. We discuss three QTL for grain yield and three for flowering time, reporting candidate genes. Power simulations show that subsets of MAGIC maize might achieve high-power and high-definition QTL mapping. We demonstrate MAGIC maize's value in identifying the genetic bases of complex traits of agronomic relevance. The design of MAGIC maize allows the accumulation of sequencing and transcriptomics layers to guide the identification of candidate genes for a number of maize traits at different developmental stages. The characterization of the full MAGIC maize population will lead to higher power and definition in QTL mapping, and lay the basis for improved understanding of maize phenotypes, heterosis included. MAGIC maize is available to researchers.

  5. Experimental Study of DQPSK Modulation on SDR Platform

    Directory of Open Access Journals (Sweden)

    Eko Marpanaji

    2013-09-01

    Full Text Available This Paper addresses Differential Quadriphase Shift Keying (DQPSK modulation implemented on SDR platform for the development of digital data  communications based on Software-Defined Radio (SDR. DQPSK modulation performance perceived at Packet Error Rate (PER is evaluated in terms of Eb/No or S/N ratio, carrier frequency, bit rate, gain, roll-off factor of root Nyquist filter or root raised cosine filter, and payload size from delivered data. Based on these results, the smallest PER could be obtained by setting Eb/No value greater than 20 dB, carrier frequency of at least 0,3 MHz, optimum bit rate of 200 kbps, optimum range payload size of 2000 up to 4000 bytes, and roll-off factor of Nyquist or root-raised cosine filter of 0.4.

  6. Experimental Study of DQPSK Modulation on SDR Platform

    Directory of Open Access Journals (Sweden)

    Eko Marpanaji

    2007-11-01

    Full Text Available This Paper addresses Differential Quadriphase Shift Keying (DQPSK modulation implemented on SDR platform for the development of digital data communications based on SDR. DQPSK modulation performance perceived at Packet Error Rate (PER is evaluated in terms of Eb/No or S/N ratio, carrier frequency, bit rate, gain, roll-off factor of root Nyquist filter or root raised cosine filter, and of size of payload from delivered data. Based on this results, the smallest PER could be obtained by setting Eb/No value which is greater than 20 dB, carrier frequency of at least 0,3 MHz, optimum bit rate of 200 kbps, optimum range payload size of 2000 up to 4000 bytes, and roll-off factor of Nyquist or root-raised cosine filter of 0.4.

  7. Large Scale Simulation Platform for NODES Validation Study

    Energy Technology Data Exchange (ETDEWEB)

    Sotorrio, P. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Qin, Y. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Min, L. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2017-04-27

    This report summarizes the Large Scale (LS) simulation platform created for the Eaton NODES project. The simulation environment consists of both wholesale market simulator and distribution simulator and includes the CAISO wholesale market model and a PG&E footprint of 25-75 feeders to validate the scalability under a scenario of 33% RPS in California with additional 17% of DERS coming from distribution and customers. The simulator can generate hourly unit commitment, 5-minute economic dispatch, and 4-second AGC regulation signals. The simulator is also capable of simulating greater than 10k individual controllable devices. Simulated DERs include water heaters, EVs, residential and light commercial HVAC/buildings, and residential-level battery storage. Feeder-level voltage regulators and capacitor banks are also simulated for feeder-level real and reactive power management and Vol/Var control.

  8. Monoclonal Antibodies Production Platforms: An Opportunity Study of a Non-Protein-A Chromatographic Platform Based on Process Economics.

    Science.gov (United States)

    Grilo, António L; Mateus, Marília; Aires-Barros, Maria R; Azevedo, Ana M

    2017-09-13

    Monoclonal antibodies currently dominate the biopharmaceutical market with growing sales having reached 80 billion USD in 2016. As most top-selling mAbs are approaching the end of their patent life, biopharmaceutical companies compete fiercely in the biosimilars market. These two factors present a strong motivation for alternative process strategies and process optimization. In this work a novel purification strategy for monoclonal antibodies comprising phenylboronic acid multimodal chromatography for capture followed by polishing by ion-exchange monolithic chromatography and packed bed hydrophobic interaction chromatography is presented and compared to the traditional protein-A-based process. Although the capital investment is similar for both processes, the operation cost is 20% lower for the novel strategy. This study shows that the new process is worthwhile investing in and could present a viable alternative to the platform process used by most industrial players. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  9. Study and Realization of Intelligent Online Drawing Platform Based on Internet

    Institute of Scientific and Technical Information of China (English)

    LIAi-jun; XUMao-feng; WANGHong-xin; ZHAOSu-yuan

    2004-01-01

    Internet has gradually demonstrated more and more superiority in modern education system. The intelligent online drawing platform based on net will provide learners with a studying environment without limitation in time and space. Based on the theory of graphics, this paper developed an intelligent online drawing platform (IODP) with Java through analyzing the teaching character of descriptive geometry. IODP developed not only has a flexible drawing environment with the function of mutual drawing, but also is able to judge the drawing made by students and give feedback at the same time. This platform gives an effective way for Internet education on engineering graphics.

  10. Pontiac fever: an operational definition for epidemiological studies

    Directory of Open Access Journals (Sweden)

    Mathieu Laurence

    2006-04-01

    Full Text Available Abstract Background Pontiac fever is usually described in epidemic settings. Detection of Pontiac fever is a marker of an environmental contamination by Legionella and should thereby call for prevention measures in order to prevent outbreak of Legionnaire's disease. The objective of this study is to propose an operational definition of Pontiac fever that is amenable to epidemiological surveillance and investigation in a non epidemic setting. Methods A population of 560 elderly subjects residing in 25 nursing homes was followed during 4 months in order to assess the daily incidence of symptoms associated, in the literature, with Pontiac fever. The water and aerosol of one to 8 showers by nursing home were characterized combining conventional bacterial culture of Legionella and the Fluorescence In Situ Hybridization (FISH technique that used oligonucleotides probes specific for Legionellaceae. A definition of Pontiac fever was devised based on clinical symptoms described in epidemic investigations and on their timing after the exposure event. The association between incidence of Pontiac fever and shower contamination levels was evaluated to test the relevance of this definition. Results The proposed definition of Pontiac fever associated the following criteria: occurrence of at least one symptom among headache, myalgia, fever and shivers, possibly associated with other 'minor' symptoms, within three days after a shower contaminated by Legionella, during a maximum of 8 days (minimum 2 days. 23 such cases occurred during the study (incidence rate: 0.125 cases per person-year [95% CI: 0.122–0.127]. A concentration of Legionella in water equal to or greater than 104.L-1 (FISH method was associated with a significant increase of incidence of Pontiac fever (p = 0.04. Conclusion Once validated in other settings, the proposed definition of Pontiac fever might be used to develop epidemiological surveillance and help draw attention on sources of

  11. Gene–Environment Interaction: Definitions and Study Designs

    OpenAIRE

    Ottman, Ruth

    1996-01-01

    Study of gene–environment interaction is important for improving accuracy and precision in the assessment of both genetic and environmental influences. This overview presents a simple definition of gene–environment interaction and suggests study designs for detecting it. Gene–environment interaction is defined as “a different effect of an environmental exposure on disease risk in persons with different genotypes,” or, alternatively, “a different effect of a genotype on disease risk in persons...

  12. A multiwell platform for studying stiffness-dependent cell biology.

    Directory of Open Access Journals (Sweden)

    Justin D Mih

    Full Text Available Adherent cells are typically cultured on rigid substrates that are orders of magnitude stiffer than their tissue of origin. Here, we describe a method to rapidly fabricate 96 and 384 well platforms for routine screening of cells in tissue-relevant stiffness contexts. Briefly, polyacrylamide (PA hydrogels are cast in glass-bottom plates, functionalized with collagen, and sterilized for cell culture. The Young's modulus of each substrate can be specified from 0.3 to 55 kPa, with collagen surface density held constant over the stiffness range. Using automated fluorescence microscopy, we captured the morphological variations of 7 cell types cultured across a physiological range of stiffness within a 384 well plate. We performed assays of cell number, proliferation, and apoptosis in 96 wells and resolved distinct profiles of cell growth as a function of stiffness among primary and immortalized cell lines. We found that the stiffness-dependent growth of normal human lung fibroblasts is largely invariant with collagen density, and that differences in their accumulation are amplified by increasing serum concentration. Further, we performed a screen of 18 bioactive small molecules and identified compounds with enhanced or reduced effects on soft versus rigid substrates, including blebbistatin, which abolished the suppression of lung fibroblast growth at 1 kPa. The ability to deploy PA gels in multiwell plates for high throughput analysis of cells in tissue-relevant environments opens new opportunities for the discovery of cellular responses that operate in specific stiffness regimes.

  13. Developing a Framework for Analyzing Definitions: A Study of "The Feynman Lectures"

    Science.gov (United States)

    Wong, Chee Leong; Chu, Hye-Eun; Yap, Kueh Chin

    2014-01-01

    One important purpose of a definition is to explain the meaning of a word. Any problems associated with a definition may impede students' learning. However, research studies on the definitional problems from the perspective of physics education are limited. Physics educators may not be aware of the nature and extent of definitional problems.…

  14. GACT: a Genome build and Allele definition Conversion Tool for SNP imputation and meta-analysis in genetic association studies.

    Science.gov (United States)

    Sulovari, Arvis; Li, Dawei

    2014-07-19

    Genome-wide association studies (GWAS) have successfully identified genes associated with complex human diseases. Although much of the heritability remains unexplained, combining single nucleotide polymorphism (SNP) genotypes from multiple studies for meta-analysis will increase the statistical power to identify new disease-associated variants. Meta-analysis requires same allele definition (nomenclature) and genome build among individual studies. Similarly, imputation, commonly-used prior to meta-analysis, requires the same consistency. However, the genotypes from various GWAS are generated using different genotyping platforms, arrays or SNP-calling approaches, resulting in use of different genome builds and allele definitions. Incorrect assumptions of identical allele definition among combined GWAS lead to a large portion of discarded genotypes or incorrect association findings. There is no published tool that predicts and converts among all major allele definitions. In this study, we have developed a tool, GACT, which stands for Genome build and Allele definition Conversion Tool, that predicts and inter-converts between any of the common SNP allele definitions and between the major genome builds. In addition, we assessed several factors that may affect imputation quality, and our results indicated that inclusion of singletons in the reference had detrimental effects while ambiguous SNPs had no measurable effect. Unexpectedly, exclusion of genotypes with missing rate > 0.001 (40% of study SNPs) showed no significant decrease of imputation quality (even significantly higher when compared to the imputation with singletons in the reference), especially for rare SNPs. GACT is a new, powerful, and user-friendly tool with both command-line and interactive online versions that can accurately predict, and convert between any of the common allele definitions and between genome builds for genome-wide meta-analysis and imputation of genotypes from SNP-arrays or deep

  15. Platform station keeping study: Ocean Thermal Energy Conversion Program. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Davidson, H. Jr.; Little, T.E.

    1977-12-01

    Station keeping considerations for the OTEC plant can have significant effect upon platform configuration and overall plant efficiency and cost. This study develops candidate configurations for dynamic positioning and mooring systems for the OTEC application, presenting parametric performance and cost data over a wide range of platform size and configuration and site environments. The data provide a general baseline, useful for OTEC system analysis, and generally applicable to future system configurations.

  16. Taking Stock of Lesson Study as a Platform for Teacher Development in Singapore

    Science.gov (United States)

    Lim, Christina; Lee, Christine; Saito, Eisuke; Haron, Sharifa Syed

    2011-01-01

    Since its introduction into Singapore schools in 2005, many schools are now implementing Lesson Study in various forms adapted to their culture, needs and priorities. Why are schools interested in Lesson Study? How has Lesson Study provided a platform for professional development of teachers? What aspects of Lesson Study have schools adapted and…

  17. A new definition of pharmaceutical quality: assembly of a risk simulation platform to investigate the impact of manufacturing/product variability on clinical performance.

    Science.gov (United States)

    Short, Steven M; Cogdill, Robert P; D'Amico, Frank; Drennen, James K; Anderson, Carl A

    2010-12-01

    The absence of a unanimous, industry-specific definition of quality is, to a certain degree, impeding the progress of ongoing efforts to "modernize" the pharmaceutical industry. This work was predicated on requests by Dr. Woodcock (FDA) to re-define pharmaceutical quality in terms of risk by linking production characteristics to clinical attributes. A risk simulation platform that integrates population statistics, drug delivery system characteristics, dosing guidelines, patient compliance estimates, production metrics, and pharmacokinetic, pharmacodynamic, and in vitro-in vivo correlation models to investigate the impact of manufacturing variability on clinical performance of a model extended-release theophylline solid oral dosage system was developed. Manufacturing was characterized by inter- and intra-batch content uniformity and dissolution variability metrics, while clinical performance was described by a probabilistic pharmacodynamic model that expressed the probability of inefficacy and toxicity as a function of plasma concentrations. Least-squares regression revealed that both patient compliance variables, percent of doses taken and dosing time variability, significantly impacted efficacy and toxicity. Additionally, intra-batch content uniformity variability elicited a significant change in risk scores for the two adverse events and, therefore, was identified as a critical quality attribute. The proposed methodology demonstrates that pharmaceutical quality can be recast to explicitly reflect clinical performance.

  18. Study and Validation of a Double Inertial Platform for a Lunar Pico-Rover

    OpenAIRE

    Jaramillo Araque, Johan Steven

    2013-01-01

    This Final Bachelor work is a study and validation of a double Inertial Measurement Unit (IMU) for a Lunar Pico-Rover. The first chapter is a review of the current market for low-cost IMUs based on Commercial off-the-shelf components. The second chapter is a study of specifications for the MultiWii SE v0.2 inertial platform, having an arduino computer with nine degrees of freedom. The third chapter is a study of specifications for the GY-80 inertial platform with also nine degrees of freedom....

  19. Satellite Power Systems (SPS) concept definition study. Volume 4: SPS point design definition

    Science.gov (United States)

    Hanley, G.

    1978-01-01

    The satellite power systems point design concept is described. The concept definition includes satellite, ground and space systems, and their relationships. Emphasis is placed on the definition of the GaAlAs photovoltaic satellite system. The major subsystems of the satellite system including power conversion, power distribution and control, microwave, attitude control and stationkeeping, thermal control, structures, and information management and control are discussed.

  20. Adapting Agriculture Platforms for Nutrition: A Case Study of a Participatory, Video-Based Agricultural Extension Platform in India

    Science.gov (United States)

    Kadiyala, Suneetha; Morgan, Emily H.; Cyriac, Shruthi; Margolies, Amy; Roopnaraine, Terry

    2016-01-01

    Successful integration of nutrition interventions into large-scale development programmes from nutrition-relevant sectors, such as agriculture, can address critical underlying determinants of undernutrition and enhance the coverage and effectiveness of on-going nutrition-specific activities. However, evidence on how this can be done is limited. This study examines the feasibility of delivering maternal, infant, and young child nutrition behaviour change communication through an innovative agricultural extension programme serving nutritionally vulnerable groups in rural India. The existing agriculture programme involves participatory production of low-cost videos promoting best practices and broad dissemination through village-level women’s self-help groups. For the nutrition intervention, 10 videos promoting specific maternal, infant, and young child nutrition practices were produced and disseminated in 30 villages. A range of methods was used to collect data, including in-depth interviews with project staff, frontline health workers, and self-help group members and their families; structured observations of mediated video dissemination sessions; nutrition knowledge tests with project staff and self-help group members; and a social network questionnaire to assess diffusion of promoted nutrition messages. We found the nutrition intervention to be well-received by rural communities and viewed as complementary to existing frontline health services. However, compared to agriculture, nutrition content required more time, creativity, and technical support to develop and deliver. Experimentation with promoted nutrition behaviours was high, but sharing of information from the videos with non-viewers was limited. Key lessons learned include the benefits of and need for collaboration with existing health services; continued technical support for implementing partners; engagement with local cultural norms and beliefs; empowerment of women’s group members to champion

  1. Platform for resource management : case studies of success or failure in Benin and Burkina Faso

    NARCIS (Netherlands)

    Dangbegnon, C.

    1998-01-01

    The present book focuses on platforms for (natural) resource management. It analyses various case studies in Benin and Burkina Faso. Conditions for collective resource management in conflict and interdependent situations are the most critical issues. The present study raises the importance

  2. Platforms for resource management: case studies of success or failure in Benin and Burkina Faso.

    NARCIS (Netherlands)

    Dangbegnon, C.

    1998-01-01

    The present book focuses on platforms for (natural) resource management. It analyses various case studies in Benin and Burkina Faso. Conditions for collective resource management in conflict and interdependent situations are the most critical issues. The present study raises the importance of socio-

  3. The LUSI LAB project: a platform for multidisciplinary experimental studies

    Science.gov (United States)

    Mazzini, Adriano; Svensen, Henrik; Hensen, Christian; Scholz, Florian; Romeo, Giovanni; Hadi, Soffian; Husein, Alwi; Planke, Sverre; Akhmanov, Grigorii; Krueger, Martin

    2014-05-01

    Lusi is a spectacular mud eruption that started in northeast Java the 29 of May 2006 following a 6.3 M earthquake. Nearly eight years later Lusi is still active. The Lusi Lab is an ERC-funded project to perform multidisciplinary studies using Lusi as a natural laboratory. This represents an unprecedented opportunity to study an ongoing active high-temperature mud eruption and to evaluate the role of seismicity, local faulting and the neighbouring Arjuno-Welirang volcanic complex on the long-lasting mud eruption. A multipurpose hexacopter has been designed and constructed to access and monitor the otherwise inaccessible Lusi crater and its mud-filled outskirts. The "Lusi drone" showed to be a powerful monitoring and sampling tool duringteh fieldwork in Dec. 2013. Videos and photogrammetry were acquired with various cameras. Designed tools allow the drone to measure and log temperature and to complete remote-controlled sampling of mud, water and gas from the erupting crater. A collection of evenly spaced mud samples has been taken along a transect that extends for 1100 m outside the crater. The incubation of these will be used for geomicrobiological studies and will help to shed light on the type of the ongoing hydrocarbon generation and degradation. A network of temperature loggers deployed around the crater aims to investigate a correlation between seismic activity and temperature variation of the erupted mud. Geochemical analyses indicate that the geochemistry of the crater water represents a geochemical anomaly when comparing with both basinal brines and volcano-hosted hot springs. A combination of high temperatures in the source region and fluid-rock interactions with silicates and carbonate-rich lithologies can explain the geochemistry. This is consistent with the result of gas analyses and with a deep-seated (>4 km) source region, possibly related to the presence of hot igneous intrusions from the volcanic arc.

  4. OCT-aided anastomosis platform study in the rodent model

    Science.gov (United States)

    Huang, Yong; Tong, Dedi; Zhu, Shan; Wu, Lehao; Ibrahim, Zuhaib; Lee, WP Andrew; Brandacher, Gerald; Kang, Jin U.

    2014-02-01

    Anastomosis is one of the most commonly performed procedure in the clinical environment that involves tubular structures, such as blood vessel, lymphatic vessel, seminal duct and ureter. Suture based anastomosis is still the foundation for most basic surgical training and clinical operation, although alternate techniques have been developed and under development. For those tubular-structure-anastomosis, immediate real-time post-operative evaluation of the surgical outcome is critical to the success of surgery. Previously evaluation is mostly based on surgeons' experience. Fourier-domain optical coherence tomography is high-speed, high-resolution noninvasive 3D imaging modality that has been widely used in the biomedical research and clinical study. In this study we used Fourier-domain optical coherence tomography as an evaluation tool for anastomosis of lymphatic vessels, ureter and seminal duct in rodent model. Immediate post-operative and long term surgical site data were collected and analyzed. Critical clinical parameters such as lumen patency, anastomosed site narrowing and suture error detection are provided to surgeons.

  5. Microfluidic platforms and fundamental electrocatalysis studies for fuel cell applications

    Science.gov (United States)

    Cohen, Jamie Lee

    The fabrication and testing of a planar membraneless microchannel fuel cell, based on a silicon microchannel, is described in detail. Laminar flow of fuel and oxidant streams, one on top of the other, prevents fuel crossover while allowing ionic transport at the interface between the two solutions. By employing laminar flow, the useful functions of a membrane are retained, while bypassing its inherent limitations. The planar design maximizes the anode and cathode areas, and elimination of the membrane affords broad flexibility in the choice of fuel and oxidant. Fuels including formic acid, methanol, ethanol, sodium borohydride and hydrogen were tested along with oxidants such as oxygen, hydrogen peroxide and potassium permanganate. Steps taken to improve voltage, current density, and overall power output have been addressed, including the testing of a dual electrolyte system and the use of micro-patterned electrode surfaces to enhance fuel utilization. As the complexity of the fuels studied in the microchannel fuel cell increased, it was imperative to characterize these fuels using electrochemical techniques prior to utilization in the fuel cell. The oxidation pathway of the liquid fuel methanol was studied rigorously because of its importance for micro-fuel cell applications. Activation energies for methanol oxidation at a Ptpoly surface were determined using electrochemical techniques, providing a benchmark for the comparison of activation energies of other Pt-based electrocatalysts for methanol oxidation at a given potential. A protocol to obtain Ea values was established in three different electrolytes and experimental parameters that influence the magnitude of these values are discussed in detail. The oxidation pathways of sodium borohydride were also examined at Au, Pt, and Pd surfaces using cyclic voltammetry, chronoamperometry, and rotating disk electrode voltammetry. In addition to studies on bulk Ptpoly surfaces, new bulk intermetallic catalysts were

  6. Microfluidic platform for studying the electrochemical reduction of carbon dioxide

    Science.gov (United States)

    Whipple, Devin Talmage

    Diminishing supplies of conventional energy sources and growing concern over greenhouse gas emissions present significant challenges to supplying the world's rapidly increasing demand for energy. The electrochemical reduction of carbon dioxide has the potential to address many of these issues by providing a means of storing electricity in chemical form. Storing electrical energy as chemicals is beneficial for leveling the output of clean, but intermittent renewable energy sources such as wind and solar. Electrical energy stored as chemicals can also be used as carbon neutral fuels for portable applications allowing petroleum derived fuels in the transportation sector to be replaced by more environmentally friendly energy sources. However, to be a viable technology, the electrochemical reduction of carbon dioxide needs to have both high current densities and energetic efficiencies (Chapter 1). Although many researchers have studied the electrochemical reduction of CO2 including parameters such as catalysts, electrolytes and temperature, further investigation is needed to improve the understanding of this process and optimize the performance (Chapter 2). This dissertation reports the development and validation of a microfluidic reactor for the electrochemical reduction of CO2 (Chapter 3). The design uses a flowing liquid electrolyte instead of the typical polymer electrolyte membrane. In addition to other benefits, this flowing electrolyte gives the reactor great flexibility, allowing independent analysis of each electrode and the testing of a wide variety of conditions. In this work, the microfluidic reactor has been used in the following areas: • Comparison of different metal catalysts for the reduction of CO2 to formic acid and carbon monoxide (Chapter 4). • Investigation of the effects of the electrolyte pH on the reduction of CO2 to formic acid and carbon monoxide (Chapter 5). • Study of amine based electrolytes for lowering the overpotentials for CO2

  7. Experimental study of tsunami-type waves impact on soil at foundations of offshore gravity platforms

    Directory of Open Access Journals (Sweden)

    N.D. Belyaev

    2014-10-01

    Full Text Available Scouring, caused by waves, currents and races of ship propellers, has been a subject of theoretical investigations, physical modeling in hydraulic laboratories and full-scale experiments in several countries. The results reported on these tests usually recommend formulas and diagrams to determine water velocities that can be used to estimate the risk of scouring and design the required protection measures. The results of the physical modeling of interaction of long tsunami-type waves with an offshore gravity platform are presented in this article. The reaction of seabed soil to wave impact at the platform foundation has been studied and the obtained results have been analyzed. Conclusions about changes in the seabed profile, density of the top layers of the seabed soil and their influence on the platform stability have been made.

  8. High-resolution studies of the Majorana atomic chain platform

    Science.gov (United States)

    Feldman, Benjamin E.; Randeria, Mallika T.; Li, Jian; Jeon, Sangjun; Xie, Yonglong; Wang, Zhijun; Drozdov, Ilya K.; Andrei Bernevig, B.; Yazdani, Ali

    2017-03-01

    Ordered assemblies of magnetic atoms on the surface of conventional superconductors can be used to engineer topological superconducting phases and realize Majorana fermion quasiparticles (MQPs) in a condensed matter setting. Recent experiments have shown that chains of Fe atoms on Pb generically have the required electronic characteristics to form a one-dimensional topological superconductor and have revealed spatially resolved signatures of localized MQPs at the ends of such chains. Here we report higher-resolution measurements of the same atomic chain system performed using a dilution refrigerator scanning tunnelling microscope (STM). With significantly better energy resolution than previous studies, we show that the zero-bias peak (ZBP) in Fe chains has no detectable splitting from hybridization with other states. The measurements also reveal that the ZBP exhibits a distinctive `double eye’ spatial pattern on nanometre length scales. Theoretically we show that this is a general consequence of STM measurements of MQPs with substantial spectral weight in the superconducting substrate, a conclusion further supported by measurements of Pb overlayers deposited on top of the Fe chains. Finally, we report experiments performed with superconducting tips in search of the particle-hole symmetric MQP signature expected in such measurements.

  9. Developing a Framework for Analyzing Definitions: A study of The Feynman Lectures

    Science.gov (United States)

    Wong, Chee Leong; Chu, Hye-Eun; Yap, Kueh Chin

    2014-10-01

    One important purpose of a definition is to explain the meaning of a word. Any problems associated with a definition may impede students' learning. However, research studies on the definitional problems from the perspective of physics education are limited. Physics educators may not be aware of the nature and extent of definitional problems. As an example, The Feynman Lectures of Physics suggest that there are at least four problems of definition: precision, circularity, context and completeness in knowledge. Feynman had the tendency of mentioning the words 'define' and 'definition' and discussing the problems of definition: they can be insightful, or challenge the conventional, preconceived notions of many physical concepts. One benefit of this study is that a framework can be developed to improve statements of definitions. This framework may guide educators or students to analyze the knowledge that is embedded in a definition. In the future, the learning of definition need not be content-oriented, but problem-based instead, with the help of definitional problems. Therefore, the use of these problems of definition in lessons can be an interesting area for future physics education research. Furthermore, we should be cognizant of inadequacies or inaccuracies in definition that may result in alternative conceptions.

  10. Effect of platform switching on the peri-implant bone: A finite element study

    Science.gov (United States)

    Martínez-González, Amparo; Peiró, Germán; Ródenas, Juan-José; López-Mollá, María-Victoria

    2015-01-01

    Background There exists a relation between the presence and location of the micro-gap and the loss of peri implant bone. Several authors have shown that the treatments based on the use of platform switching result in less peri-implant bone loss and an increased tissue stability. The purpose of this study was to analyse the effect of the platform switching on the distribution of stresses on the peri-implant bone using the finite element method. Material and Methods A realistic 3D full-mandible finite element model representing cortical bone and trabecular bone was used to study the distribution of the stress on the bone induced by an implant of diameter 4.1 mm. Two abutments were modelled. The first one, of diameter 4.1 mm, was used in the reference model to represent a conventional implant. The second one, of diameter 3.2 mm, was used to represent the implant with platform switching. Both models were subjected to axial and oblique masticatory loads. Results The analyses showed that, although no relevant differences can be found for the trabecular bone, the use of platform switching reduces the maximum stress level in the cortical bone by almost 36% with axial loads and by 40% with oblique loads. Conclusions The full 3D Finite Element model, that can be used to investigate the influence of other parameters (implant diameter, connexion type, …) on the biomechanical behaviour of the implant, showed that this stress reduction can be a biomechanical reasons to explain why the platform switching seems to reduce or eliminate crestal bone resorption after the prosthetic restoration. Key words:Dental implant, platform switching, finite element method. PMID:26535094

  11. The Turkish Version of Web-Based Learning Platform Evaluation Scale: Reliability and Validity Study

    Science.gov (United States)

    Dag, Funda

    2016-01-01

    The purpose of this study is to determine the language equivalence and the validity and reliability of the Turkish version of the "Web-Based Learning Platform Evaluation Scale" ("Web Tabanli Ögrenme Ortami Degerlendirme Ölçegi" [WTÖODÖ]) used in the selection and evaluation of web-based learning environments. Within this scope,…

  12. A prospective cohort study evaluating a novel colonoscopy platform featuring full-spectrum endoscopy

    NARCIS (Netherlands)

    Gralnek, Ian Mark; Segol, Ori; Suissa, Alain; Siersema, Peter D.; Carr-Locke, David L.; Halpern, Zamir; Santo, Erwin; Domanov, Svetlana

    2013-01-01

    Background and study aims: Although colonoscopy is the criterion standard for detecting colorectal adenomas and cancers, a significant percentage of adenomas are missed with this technique. We aimed to establish the feasibility, usability, and safety of a novel colonoscopy platform featuring full-sp

  13. Individual Factors That Encourage the Use of Virtual Platforms of Administrative Sciences Students: A Case Study

    Science.gov (United States)

    Arias, Alejandro Valencia; Naffah, Salim Chalela; Bermudez Hernández, Jonathan; Bedoya Pérez, Luz Mirelia

    2015-01-01

    Higher education Institutions have incorporated into their educational processes the virtual learning platforms use, in their search to answers to the dynamic and changing needs of young students, thus students have practical training in the use of information technologies and communication (ICT) in their curses. However, few studies have been…

  14. The Imperial College Cambridge Manchester (ICCAM) platform study: An experimental medicine platform for evaluating new drugs for relapse prevention in addiction. Part A: Study description.

    Science.gov (United States)

    Paterson, Louise M; Flechais, Remy S A; Murphy, Anna; Reed, Laurence J; Abbott, Sanja; Boyapati, Venkataramana; Elliott, Rebecca; Erritzoe, David; Ersche, Karen D; Faluyi, Yetunde; Faravelli, Luca; Fernandez-Egea, Emilio; Kalk, Nicola J; Kuchibatla, Shankar S; McGonigle, John; Metastasio, Antonio; Mick, Inge; Nestor, Liam; Orban, Csaba; Passetti, Filippo; Rabiner, Eugenii A; Smith, Dana G; Suckling, John; Tait, Roger; Taylor, Eleanor M; Waldman, Adam D; Robbins, Trevor W; Deakin, J F William; Nutt, David J; Lingford-Hughes, Anne R

    2015-09-01

    Drug and alcohol dependence are global problems with substantial societal costs. There are few treatments for relapse prevention and therefore a pressing need for further study of brain mechanisms underpinning relapse circuitry. The Imperial College Cambridge Manchester (ICCAM) platform study is an experimental medicine approach to this problem: using functional magnetic resonance imaging (fMRI) techniques and selective pharmacological tools, it aims to explore the neuropharmacology of putative relapse pathways in cocaine, alcohol, opiate dependent, and healthy individuals to inform future drug development. Addiction studies typically involve small samples because of recruitment difficulties and attrition. We established the platform in three centres to assess the feasibility of a multisite approach to address these issues. Pharmacological modulation of reward, impulsivity and emotional reactivity were investigated in a monetary incentive delay task, an inhibitory control task, and an evocative images task, using selective antagonists for µ-opioid, dopamine D3 receptor (DRD3) and neurokinin 1 (NK1) receptors (naltrexone, GSK598809, vofopitant/aprepitant), in a placebo-controlled, randomised, crossover design. In two years, 609 scans were performed, with 155 individuals scanned at baseline. Attrition was low and the majority of individuals were sufficiently motivated to complete all five sessions (n=87). We describe herein the study design, main aims, recruitment numbers, sample characteristics, and explain the test hypotheses and anticipated study outputs.

  15. Product Platform Performance

    DEFF Research Database (Denmark)

    Munk, Lone

    engaging in platform-based product development. Similarly platform assessment criteria lack empirical verification regarding relevance and sufficiency. The thesis focuses on • the process of identifying and estimating internal effects, • verification of performance of product platforms, (i...... to support this understanding. Finally a categorisation of different approaches to platform-based product development is introduced, based on the companies from the industrial study.......The aim of this research is to improve understanding of platform-based product development by studying platform performance in relation to internal effects in companies. Platform-based product development makes it possible to deliver product variety and at the same time reduce the needed resources...

  16. Case studies can support definitions of workplace innovation in practice

    NARCIS (Netherlands)

    Vaas, F.; Žiauberytė-Jakštienė, R.; Oeij, P.R.

    2017-01-01

    Many practitioners find it problematic to understand and describe workplace innovation (WPI). Whereas there are well-known definitions of WPI, these remain highly abstract. We argue that, for practitioners, case examples of WPI best practices can be a valuable addition to these definitions. In this

  17. Survey Definitions of Gout for Epidemiologic Studies: Comparison With Crystal Identification as the Gold Standard.

    Science.gov (United States)

    Dalbeth, Nicola; Schumacher, H Ralph; Fransen, Jaap; Neogi, Tuhina; Jansen, Tim L; Brown, Melanie; Louthrenoo, Worawit; Vazquez-Mellado, Janitzia; Eliseev, Maxim; McCarthy, Geraldine; Stamp, Lisa K; Perez-Ruiz, Fernando; Sivera, Francisca; Ea, Hang-Korng; Gerritsen, Martijn; Scire, Carlo A; Cavagna, Lorenzo; Lin, Chingtsai; Chou, Yin-Yi; Tausche, Anne-Kathrin; da Rocha Castelar-Pinheiro, Geraldo; Janssen, Matthijs; Chen, Jiunn-Horng; Cimmino, Marco A; Uhlig, Till; Taylor, William J

    2016-12-01

    To identify the best-performing survey definition of gout from items commonly available in epidemiologic studies. Survey definitions of gout were identified from 34 epidemiologic studies contributing to the Global Urate Genetics Consortium (GUGC) genome-wide association study. Data from the Study for Updated Gout Classification Criteria (SUGAR) were randomly divided into development and test data sets. A data-driven case definition was formed using logistic regression in the development data set. This definition, along with definitions used in GUGC studies and the 2015 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) gout classification criteria were applied to the test data set, using monosodium urate crystal identification as the gold standard. For all tested GUGC definitions, the simple definition of "self-report of gout or urate-lowering therapy use" had the best test performance characteristics (sensitivity 82%, specificity 72%). The simple definition had similar performance to a SUGAR data-driven case definition with 5 weighted items: self-report, self-report of doctor diagnosis, colchicine use, urate-lowering therapy use, and hyperuricemia (sensitivity 87%, specificity 70%). Both of these definitions performed better than the 1977 American Rheumatism Association survey criteria (sensitivity 82%, specificity 67%). Of all tested definitions, the 2015 ACR/EULAR criteria had the best performance (sensitivity 92%, specificity 89%). A simple definition of "self-report of gout or urate-lowering therapy use" has the best test performance characteristics of existing definitions that use routinely available data. A more complex combination of features is more sensitive, but still lacks good specificity. If a more accurate case definition is required for a particular study, the 2015 ACR/EULAR gout classification criteria should be considered. © 2016, American College of Rheumatology.

  18. Finding information about mental health in microblogging platforms: a Case study of depression

    OpenAIRE

    Wilson, Max L.; Ali, Susan Abubakir; Valstar, Michel F.

    2014-01-01

    Searching for online health information has been well studied in web search, but social media, such as public microblogging services, are well known for different types of tacit information: personal experience and shared information. Finding useful information in public microblogging platforms is an on-going hard problem and so to begin to develop a better model of what health information can be found, Twitter posts using the word “depression” were examined as a case study of a search for a ...

  19. Selective linking from social platforms to university websites: a case study of the Spanish academic system

    CERN Document Server

    Orduna-Malea, Enrique

    2013-01-01

    Mention indicators have frequently been used in Webometric studies because they provide a powerful tool for determining the degree of visibility and impact of web resources. Among mention indicators, hypertextual links were a central part of many studies until Yahoo discontinued the linkdomain command in 2011. Selective links constitute a variant of external links where both the source and target of the link can be selected. This paper intends to study the influence of social platforms (measured through the number of selective external links) on academic environments, in order to ascertain both the percentage that they constitute and whether some of them can be used as substitutes of total external links. For this purpose, 141 URLs belonging to 76 Spanish universities were compiled in 2010 (before Yahoo! stopped their link services), and the number of links from 13 selected social platforms to these universities were calculated. Results confirm a good correlation between total external links and links that co...

  20. Study on the Relation of Definite Integral and Indefinite Integral

    Institute of Scientific and Technical Information of China (English)

    SUN Bao-fa

    2014-01-01

    Relation of definite integral and indefinite integral was discussed and an impor-tant result was gotten. If f (x) is bounded and has primary function, the formal definite integral R sx f˜(t)dt is the indefinite integral of f (x), where x is a self-variable, s is a param-eter, f˜(x) is a function defined in (−∞, +∞), which comes from f (x) by restriction and extension. In other words, the indefinite integral is a special form of definite integral, its lower integral limit and upper integral limit are all indefinite.

  1. A prototypic microfluidic platform generating stepwise concentration gradients for real-time study of cell apoptosis.

    Science.gov (United States)

    Dai, Wen; Zheng, Yizhe; Luo, Kathy Qian; Wu, Hongkai

    2010-04-16

    This work describes the development of a prototypic microfluidic platform for the generation of stepwise concentration gradients of drugs. A sensitive apoptotic analysis method is integrated into this microfluidic system for studying apoptosis of HeLa cells under the influence of anticancer drug, etoposide, with various concentrations in parallel; it measures the yellow fluorescent proteincyan fluorescent protein fluorescence resonance energy transfer (FRET) signal that responds to the activation of caspase-3, an indicator of cell apoptosis. Sets of microfluidic valves on the chip generate stepwise concentration gradient of etoposide in various cell-culture microchambers. The FRET signals from multiple chambers are simultaneously monitored under a fluorescent microscope for long-time observation and the on-chip results are compared with those from 96-well plate study and the methylthiazolyldiphenyl-tetrazolium bromide (MTT) assay. The microfluidic platform shows several advantages including high-throughput capacity, low drug consumption, and high sensitivity.

  2. Observational study of 67 wide platform implants treated with avantblast surface. Results at three year.

    Science.gov (United States)

    Barona-Dorado, Cristina; Martínez-Rodríguez, Natalia; Torres-Lear, Francisco; Martínez-González, José-Ma

    2009-04-01

    This paper shows the results of the clinical and radiographic behavior, at 3 years, of 67 wide platform implants undergoing prosthetic load. This is an observational prospective study of 67 implants in 49 patients within the range of 54-69 years of age. Screening was performed after a radiological study with panoramic and tomographic radiographs followed by the implantological treatment with prosthetic load and clinical (15 days, 1, 6, 12, 24 and 36 months) and radiological control follow-up (6, 12, 24 and 36 months). During the healing period 1 implant failed, representing a 98.5% survival. After placing the prosthesis, it was not necessary to remove any implant, therefore 66 implants remain successfully in place. The favorable results and follow-up after the prosthetic load of 66 implants (CSR of 100%) attest that wide platform implants can and should be applied after careful planning and case selection.

  3. A technical platform for environments for ageing--lessons learned from three field studies.

    Science.gov (United States)

    Eichelberg, Marco; Büsching, Felix; Steen, Enno-Edzard; Helmer, Axel; Thiel, Andreas; Hein, Andreas; Wolf, Lars

    2014-01-01

    The Lower Saxony Research Network "Design of Environments for Ageing" (GAL) studied possible applications of assistive technology for enabling older adults to live longer and independent in their own home. As part of this work, a technical platform was developed as a common technical basis for all assistive systems in the project. This article presents an overview of the architecture and core functionality of the technical platform, which in the first generation was developed for use in a laboratory setting, and in a second generation was extended for use in the project's field studies, i.e. prototype installations in end-users homes. The field studies' primary objective was the evaluation of the assistive technologies, that were developed within the overall project. However, these studies also confirmed that the fundamental concept of the technical platform is valid, and the prototypes continuously worked 24 h a day for several months. However, there were some problems related to lack of infrastructure in the older adults' homes and human factors such as inadvertent placement of objects across sensors' field of view, acceptance problems due to aesthetical reasons or simply communication problems, which show that making complex technologies work for users with little technical experience is well possible, but requires a careful consideration of the complete service chain and related "soft factors".

  4. Modeling platform for integrated assessment of intervention propolsals in localities : case study, Medellin Metropolitan Area (Colombia)

    OpenAIRE

    2011-01-01

    This dissertation proposes a comprehensive framework for conceptual, methodological and instrumental contribution to urban intervention planning and public policy design. For a Latin American case study, a prospective multi-methodology modeling platform was developed to support the novel proposed approaches for intervention assessment, as well as to establish a knowledge building dynamic for planners using multidisciplinary discussion and, most importantly, paradigm confrontation and change. ...

  5. Service Quality of Online Shopping Platforms: A Case-Based Empirical and Analytical Study

    OpenAIRE

    Tsan-Ming Choi; Pui-Sze Chow; Bowood Kwok; Shuk-Ching Liu; Bin Shen

    2013-01-01

    Customer service is crucially important for online shopping platforms (OSPs) such as eBay and Taobao. Based on the well-established service quality instruments and the scenario of the specific case on Taobao, this paper focuses on exploring the service quality of an OSP with an aim of revealing customer perceptions of the service quality associated with the provided functions and investigating their impacts on customer loyalty. By an empirical study, this paper finds that the “fulfillment and...

  6. A Study on Immersion of Hand Interaction for Mobile Platform Virtual Reality Contents

    OpenAIRE

    Seunghun Han; Jinmo Kim

    2017-01-01

    This study proposes gaze-based hand interaction, which is helpful for improving the user’s immersion in the production process of virtual reality content for the mobile platform, and analyzes efficiency through an experiment using a questionnaire. First, three-dimensional interactive content is produced for use in the proposed interaction experiment while presenting an experiential environment that gives users a high sense of immersion in the mobile virtual reality environment. This is design...

  7. Measuring Maternal Mortality: Three Case Studies Using Verbal Autopsy with Different Platforms.

    Directory of Open Access Journals (Sweden)

    Siân L Curtis

    Full Text Available Accurate measurement of maternal mortality is needed to develop a greater understanding of the scale of the problem, to increase effectiveness of program planning and targeting, and to track progress. In the absence of good quality vital statistics, interim methods are used to measure maternal mortality. The purpose of this study is to document experience with three community-based interim methods that measure maternal mortality using verbal autopsy.This study uses a post-census mortality survey, a sample vital registration with verbal autopsy, and a large-scale household survey to summarize the measures of maternal mortality obtained from these three platforms, compares and contrasts the different methodologies employed, and evaluates strengths and weaknesses of each approach. Included is also a discussion of issues related to death identification and classification, estimating maternal mortality ratios and rates, sample sizes and periodicity of estimates, data quality, and cost.The sample sizes vary considerably between the three data sources and the number of maternal deaths identified through each platform was small. The proportion of deaths to women of reproductive age that are maternal deaths ranged from 8.8% to 17.3%. The maternal mortality rate was estimable using two of the platforms while obtaining an estimate of the maternal mortality ratio was only possible using one of the platforms. The percentage of maternal deaths due to direct obstetric causes ranged from 45.2% to 80.4%.This study documents experiences applying standard verbal autopsy methods to estimate maternal mortality and confirms that verbal autopsy is a feasible method for collecting maternal mortality data. None of these interim methods are likely to be suitable for detecting short term changes in mortality due to prohibitive sample size requirements, and thus, comprehensive and continuous civil registration systems to provide high quality vital statistics are essential

  8. Device Data Ingestion for Industrial Big Data Platforms with a Case Study.

    Science.gov (United States)

    Ji, Cun; Shao, Qingshi; Sun, Jiao; Liu, Shijun; Pan, Li; Wu, Lei; Yang, Chenglei

    2016-02-26

    Despite having played a significant role in the Industry 4.0 era, the Internet of Things is currently faced with the challenge of how to ingest large-scale heterogeneous and multi-type device data. In response to this problem we present a heterogeneous device data ingestion model for an industrial big data platform. The model includes device templates and four strategies for data synchronization, data slicing, data splitting and data indexing, respectively. We can ingest device data from multiple sources with this heterogeneous device data ingestion model, which has been verified on our industrial big data platform. In addition, we present a case study on device data-based scenario analysis of industrial big data.

  9. A microfluidic platform to study the mechano sensational properties of ion channels

    Science.gov (United States)

    Baratchi, Sara; Tovar-Lopez, Francisco J.; Khoshmanesh, Khashayar; Grace, Megan; Darby, William; McIntyre, Peter; Mitchell, Arnan

    2013-12-01

    Microfluidic platforms have been widely considered as an enabling technology for studying the ion transport phenomena of cells under precisely controlled shear stresses. Here, we report the application of a unique microfluidic platform to analyze the response of transgenic TRPV4-HEK293 cells in response to different shear stresses and in one field of view. Applying this system, we show the kinetics of calcium signalling at different shear stresses in TRPV4 positive cells and elucidate the threshold of their response. We show that there is direct correlation between the magnitude of shear stress and percentage of cells that are able to sense that level of shear. Further, we show that shear stress-induced elevation in intracellular calcium levels ([Ca2+]i) is through calcium influx from extracellular sources. The results demonstrate that the microfluidic system has unique capabilities for analysis of shear stress on adhesive cells and that it should be amenable to moderate throughput applications.

  10. Retina-on-a-chip: a microfluidic platform for point access signaling studies.

    Science.gov (United States)

    Dodson, Kirsten H; Echevarria, Franklin D; Li, Deyu; Sappington, Rebecca M; Edd, Jon F

    2015-12-01

    We report on a microfluidic platform for culture of whole organs or tissue slices with the capability of point access reagent delivery to probe the transport of signaling events. Whole mice retina were maintained for multiple days with negative pressure applied to tightly but gently bind the bottom of the retina to a thin poly-(dimethylsiloxane) membrane, through which twelve 100 μm diameter through-holes served as fluidic access points. Staining with toluidine blue, transport of locally applied cholera toxin beta, and transient response to lipopolysaccharide in the retina demonstrated the capability of the microfluidic platform. The point access fluidic delivery capability could enable new assays in the study of various kinds of excised tissues, including retina.

  11. Device Data Ingestion for Industrial Big Data Platforms with a Case Study

    Science.gov (United States)

    Ji, Cun; Shao, Qingshi; Sun, Jiao; Liu, Shijun; Pan, Li; Wu, Lei; Yang, Chenglei

    2016-01-01

    Despite having played a significant role in the Industry 4.0 era, the Internet of Things is currently faced with the challenge of how to ingest large-scale heterogeneous and multi-type device data. In response to this problem we present a heterogeneous device data ingestion model for an industrial big data platform. The model includes device templates and four strategies for data synchronization, data slicing, data splitting and data indexing, respectively. We can ingest device data from multiple sources with this heterogeneous device data ingestion model, which has been verified on our industrial big data platform. In addition, we present a case study on device data-based scenario analysis of industrial big data. PMID:26927121

  12. A study on interaction App platform between expert knowledge and community applied on disaster education

    Science.gov (United States)

    Ruljigaljig, T.; Huang, M. L.

    2015-12-01

    This study development interface for Mobile Application (App) use cloud technology, Web 2.0 and online community of technology to build the Environmental-Geological Disaster Network(EDN). The interaction App platform between expert knowledge and community is developed as a teaching tool, which bases on the open data released by Central Geological Survey. The APP can through Augmented Reality technology to potential hazards position through the camera lens, the real show in real-world environment. The interaction with experts in the community to improve the general public awareness of disaster. Training people to record the occurrence of geological disasters precursor, thereby awakened their to natural disaster consciousness and attention.General users obtain real-time information during travel, mountaineering and teaching process. Using App platform to upload and represent the environmental geological disaster data collected by themselves. It is expected that by public joint the open platform can accumulate environmental geological disaster data effectively, quickly, extensively and correctly. The most important thing of this study is rooting the concept of disaster prevention, reduction, and avoidance through public participation.

  13. Crossover versus Stabilometric Platform for the Treatment of Balance Dysfunction in Parkinson's Disease: A Randomized Study.

    Science.gov (United States)

    Frazzitta, G; Bossio, F; Maestri, R; Palamara, G; Bera, R; Ferrazzoli, D

    2015-01-01

    Balance dysfunctions are a major challenge in the treatment of Parkinson's disease (PD). Previous studies have shown that rehabilitation can play a role in their treatment. In this study, we have compared the efficacy of two different devices for balance training: stabilometric platform and crossover. We have enrolled 60 PD patients randomly assigned to two groups. The first one (stabilometric group) performed a 4-week cycle of balance training, using the stabilometric platform, whereas the second one (crossover group) performed a 4-week cycle of balance training, using the crossover. The outcome measures used were Unified Parkinson's Disease Rating Scale (UPDRS) part II, Berg Balance Scale (BBS), Timed Up and Go (TUG), and Six Minutes Walking Test (6MWT). Results showed that TUG, BBS, and UPDRS II improved in both groups. There was not difference in the efficacy of the two balance treatments. Patients in both groups improved also the meters walked in the 6MWT at the end of rehabilitation, but the improvement was better for patients performing crossover training. Our results show that the crossover and the stabilometric platform have the same effect on balance dysfunction of Parkinsonian patients, while crossover gets better results on the walking capacity.

  14. Survey Definitions of Gout for Epidemiologic Studies: Comparison With Crystal Identification as the Gold Standard

    NARCIS (Netherlands)

    Dalbeth, N.; Schumacher, H.R.; Fransen, J.; Neogi, T.; Jansen, T.L; Brown, M.; Louthrenoo, W.; Vazquez-Mellado, J.; Eliseev, M.; McCarthy, G.; Stamp, L.K.; Perez-Ruiz, F.; Sivera, F.; Ea, H.K.; Gerritsen, M.; Scire, C.A.; Cavagna, L.; Lin, C.; Chou, Y.Y.; Tausche, A.K.; Rocha Castelar-Pinheiro, G. da; Janssen, M; Chen, J.H.; Cimmino, M.A.; Uhlig, T.; Taylor, W.J.

    2016-01-01

    OBJECTIVE: To identify the best-performing survey definition of gout from items commonly available in epidemiologic studies. METHODS: Survey definitions of gout were identified from 34 epidemiologic studies contributing to the Global Urate Genetics Consortium (GUGC) genome-wide association study.

  15. THE NATURE OF USING VIRTUAL WORLDS BY A CHILD AS A LEARNING PLATFORM: A Case Study

    Directory of Open Access Journals (Sweden)

    Ahmet BAYTAK

    2011-08-01

    Full Text Available The development of new technologies is found inevitable and children interests toward online platforms and virtual worlds are rapidly growing. In addition, there is a consensus that use of technology for primary or secondary school education is effective for achievement and motivation. In research and practice there are many educational implementations of technology in classrooms that were found useful.Similar to most qualitative studies, the purpose of this study also cannot be narrowed down to a single sentence but the overarching aim of the study is to explore the nature of using virtual worlds as a learning platform during. The theoretical background of this study is rooted from the constructivism and constructionism learning approaches. Consisted with its theoretical framework, this study has followed a qualitative case study research method to explore the nature of the construct. The case is a bounded system that is narrowed to a single case (Merriam, 1988; Stake, 1995; Yin, 2003. There are various types of data collected within this system. Based on the data collected and the research-suggested case study data analysis approaches, the following themes were emerged; realty, learning by discovering, learning by design, scaffolding and chunking information, and real life desires.After using Whyville virtual platform, the aim of this study was expected to start new discussion on young children using more complex virtual worlds such as Second Life. Thus, the results of this study could be guidance for transmission process of children toward Second Life type of virtual worlds. Even though a further discussion may need about the nature of using the virtual worlds, the primary findings of these case studies suggest some practical implications for children’s education.

  16. Mobile platform for treatment of stroke: A case study of tele-assistance.

    Science.gov (United States)

    Torres Zenteno, Arturo Henry; Fernández, Francisco; Palomino-García, Alfredo; Moniche, Francisco; Escudero, Irene; Jiménez-Hernández, M Dolores; Caballero, Auxiliadora; Escobar-Rodriguez, Germán; Parra, Carlos

    2016-09-01

    This article presents the technological solution of a tele-assistance process for stroke patients in acute phase in the Seville metropolitan area. The main objective of this process is to reduce time from symptom onset to treatment of acute phase stroke patients by means of telemedicine, regarding mobility between an intensive care unit ambulance and an expert center and activating the pre-hospital care phase. The technological platform covering the process has been defined following an interoperability model based on standards and with a focus on service-oriented architecture focus. Messaging definition has been designed according to the reference model of the CEN/ISO 13606, messages content follows the structure of archetypes. An XDS-b (Cross-Enterprise Document Sharing-b) transaction messaging has been designed according to Integrating the Healthcare Enterprise profile for archetype notifications and update enquiries.This research has been performed by a multidisciplinary group. The Virgen del Rocío University Hospital acts as Reference Hospital and the Public Company for Healthcare as mobility surroundings. © The Author(s) 2015.

  17. National Biomedical Tracer Facility (NBTF). Project definition study: Phase I

    Energy Technology Data Exchange (ETDEWEB)

    Lagunas-Solar, M.C.

    1995-02-15

    This report describes a five-year plan for the construction and commissioning of a reliable and versatile NBTF facility for the production of high-quality, high-yield radioisotopes for research, biomedical, and industrial applications. The report is organized in nine sections providing, in consecutive order, responses to the nine questions posed by the U.S. Department of Energy in its solicitation for the NBTF Project Definition Study. In order to preserve direct correspondence (e.g., Sec. 3 = 3rd item), this Introduction is numbered {open_quotes}0.{close_quotes} Accelerator and facility designs are covered in Section 1 (Accelerator Design) and Section 2 (Facility Design). Preliminary estimates of capital costs are detailed in Section 3 (Design and Construction Costs). Full licensing requirements, including federal, state, and local ordinances, are discussed in Section 4 (Permits). A plan for the management of hazardous materials to be generated by NBTF is presented in Section 5 (Waste Management). An evaluation of NBTF`s economic viability and its potential market impact is detailed in Section 6(Business Plan), and is complemented by the plans in Section 7 (Operating Plan) and Section 8 (Radioisotope Plan). Finally, a plan for NBTF`s research, education, and outreach programs is presented in Section 9 (Research and Education Programs).

  18. RESEARCH REPORT: Definitions of Physical Concepts: A study of physics teachers' knowledge and views

    Science.gov (United States)

    Galili, Igal; Lehavi, Yaron

    2006-04-01

    A study was made of the ability of a population of high-school physics teachers to define physics concepts and of their views regarding the importance of such definitions. It was found possible to arrange the definitions accumulated in categories, and the classification so obtained was consonant with that of the philosophy of science. Although the subjects of this study were experienced teachers, the definitions they supplied exhibited shortcomings. Despite this, however, the teachers attached great importance to a knowledge of concept definitions. The implications of these findings in connection with the ongoing debate regarding the importance of concept definitions in science education are discussed. The high educational value of concept definitions is argued and a deficiency in this knowledge points to the shortcoming in teacher training.

  19. Comparison of definitions for the metabolic syndrome in adolescents. The HELENA study.

    Science.gov (United States)

    Vanlancker, Tine; Schaubroeck, Emmily; Vyncke, Krishna; Cadenas-Sanchez, Cristina; Breidenassel, Christina; González-Gross, Marcela; Gottrand, Frederic; Moreno, Luis A; Beghin, Laurent; Molnár, Denes; Manios, Yannis; Gunter, Marc J; Widhalm, Kurt; Leclercq, Catherine; Dallongeville, Jean; Ascensión, Marcos; Kafatos, Anthony; Castillo, Manuel J; De Henauw, Stefaan; Ortega, Francisco B; Huybrechts, Inge

    2017-02-01

    Various definitions are used to define metabolic syndrome in adolescents. This study aimed to compare, in terms of prevalence and differences, five frequently used definitions for this population: International Diabetes Federation, National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP) modified by Cook, pediatric American Heart Association (AHA), World Health Organization, and Jolliffe and Janssen. A sample of 1004 adolescents (12.5-17.0 years) from the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study was considered. The components of the definitions (waist circumference/BMI, plasma lipids, glycemia, and blood pressure) were applied, and definitions were compared by using crosstabs, sensitivity, specificity, and kappa coefficient. The prevalence of metabolic syndrome varied from 1.6 to 3.8% depending on the used definitions. Crosstabs comparing the definitions showed the fewest cases being misclassified (having metabolic syndrome or not) between NCEP-ATP and AHA. Analyses for kappa coefficient, sensitivity, and specificity confirmed this finding.

  20. Generating Ideas on Online Platforms: A Case Study of “My Starbucks Idea”

    Directory of Open Access Journals (Sweden)

    Mokter Hossain

    2015-10-01

    Full Text Available The objective of this study is to explore the factors that are keys for an idea to be implemented on an online crowdsourcing platform. A data set of 320 implemented ideas from My Starbucks Idea – an online crowdsourcing platform – has been analyzed. We find that only one out of 500 users’ submitted ideas are selected for implementation. The number of implemented ideas increases significantly at the early stage of the platform. At the mature stage, even though an increasing number of ideas are submitted, implemented ideas are proportionately low. Among the three categories of ideas – product, experience, and involvement – ideas of the product category are implemented with lower values of some associated variables than that of the experience category whereas those values in the involvement category are higher. Linked ideas need lower scores than sole ideas to get implemented. The chance that an idea to be implemented largely depends on votes received by and points earned on that idea.

  1. Real-time Leishmania genus master mix: a platform compatibility and stability study.

    Science.gov (United States)

    Melanson, Vanessa R; Scheirer, Jessica L; Kalina, Warren V; Wagar, Eric J

    2014-10-01

    Performing diagnostics and vector-pathogen surveillance in austere environments is challenging. On-site diagnostic/detection mitigates vector-borne disease complications during military or humanitarian deployments to disease endemic locals. The mobile molecular diagnostic platform, Joint Biological Agent Identification and Diagnostic System (JBAIDS; BioFire Diagnostics Inc., Salt Lake City, UT, USA), rapidly identifies biothreat pathogens. Although ideal for remote diagnostics, the platform was validated for specific pathogens of insignificant epidemiological consequence. Recognizing the JBAIDS's remote diagnostic/detection versatility, we tested a Leishmania genus real-time PCR master mix validated for use on the SmartCycler® (Cepheid, Sunnyvale, CA, USA) for concomitant use on the JBAIDS. We evaluated assay sensitivity, precision, and specificity of one or more Leishmania spp. on the JBAIDS and found that the JBAIDS produces superior detection sensitivity and specificity compared to the SmartCycler®. We also examined the storage stability of a bulk lot preparation of the Leishmania genus real-time PCR master mix on the SmartCycler® to ensure that long periods of frozen storage that would translate to a field environment with the JBAIDS were not detrimental to the reagent. We found that the bulk master mix maintains its stability over a 13-month time period. Overall, these studies confirm JBAIDS's versatility and demonstrate a streamlined assay development approach where reagents are compatible with both platforms. Copyright © 2014. Published by Elsevier Inc.

  2. The MSFC Collaborative Engineering Process for Preliminary Design and Concept Definition Studies

    Science.gov (United States)

    Mulqueen, Jack; Jones, David; Hopkins, Randy

    2011-01-01

    This paper describes a collaborative engineering process developed by the Marshall Space Flight Center's Advanced Concepts Office for performing rapid preliminary design and mission concept definition studies for potential future NASA missions. The process has been developed and demonstrated for a broad range of mission studies including human space exploration missions, space transportation system studies and in-space science missions. The paper will describe the design team structure and specialized analytical tools that have been developed to enable a unique rapid design process. The collaborative engineering process consists of integrated analysis approach for mission definition, vehicle definition and system engineering. The relevance of the collaborative process elements to the standard NASA NPR 7120.1 system engineering process will be demonstrated. The study definition process flow for each study discipline will be will be outlined beginning with the study planning process, followed by definition of ground rules and assumptions, definition of study trades, mission analysis and subsystem analyses leading to a standardized set of mission concept study products. The flexibility of the collaborative engineering design process to accommodate a wide range of study objectives from technology definition and requirements definition to preliminary design studies will be addressed. The paper will also describe the applicability of the collaborative engineering process to include an integrated systems analysis approach for evaluating the functional requirements of evolving system technologies and capabilities needed to meet the needs of future NASA programs.

  3. A Comparison of Platform Options for Deep-water Floating Offshore Vertical Axis Wind Turbines: An Initial Study.

    Energy Technology Data Exchange (ETDEWEB)

    Bull, Diana L; Fowler, Matthew; Goupee, Andrew

    2014-08-01

    This analysis utilizes a 5 - MW VAWT topside design envelope created by Sandia National Laborator ies to compare floating platform options fo r each turbine in the design space. The platform designs are based on two existing designs, the OC3 Hywind spar - buoy and Principal Power's WindFloat semi - submersible. These designs are scaled using Froude - scaling relationships to determine an appropriately sized spar - buoy and semi - submersible design for each topside. Both the physical size of the required platform as well as mooring configurations are considered. Results are compared with a comparable 5 - MW HAWT in order to identify potential differences in the platform and mooring sizing between the VAWT and HAWT . The study shows that there is potential for cost savings due to reduced platform size requirements for the VAWT.

  4. Analysis of agreement among definitions of metabolic syndrome in nondiabetic Turkish adults: a methodological study

    Directory of Open Access Journals (Sweden)

    Bersot Thomas P

    2007-12-01

    Full Text Available Abstract Background We aimed to explore the agreement among World Health Organization (WHO, European Group for the Study of Insulin Resistance (EGIR, National Cholesterol Education Program (NCEP, American College of Endocrinology (ACE, and International Diabetes Federation (IDF definitions of the metabolic syndrome. Methods 1568 subjects (532 men, 1036 women, mean age 45 and standard deviation (SD 13 years were evaluated in this cross-sectional, methodological study. Cardiometabolic risk factors were determined. Insulin sensitivity was calculated by HOMA-IR. Agreement among definitions was determined by the kappa statistic. ANOVA and post hoc Tukey's test were used to compare multiple groups. Results The agreement between WHO and EGIR definitions was very good (kappa: 0.83. The agreement between NCEP, ACE, and IDF definitions was substantial to very good (kappa: 0.77–0.84. The agreement between NCEP or ACE or IDF and WHO or EGIR definitions was fair (kappa: 0.32–0.37. The age and sex adjusted prevalence of metabolic syndrome was 38% by NCEP, 42% by ACE and IDF, 20% by EGIR and 19% by WHO definition. The evaluated definitions were dichotomized after analysis of design, agreement and prevalence: insulin measurement requiring definitions (WHO and EGIR and definitions not requiring insulin measurement (NCEP, ACE, IDF. One definition was selected from each set for comparison. WHO-defined subjects were more insulin resistant than subjects without the metabolic syndrome (mean and SD for log HOMA-IR, 0.53 ± 0.14 vs. 0.07 ± 0.23, respectively, p 0.05, but lower log HOMA-IR values (p Conclusion The metabolic syndrome definitions that do not require measurement of insulin levels (NCEP, ACE and IDF identify twice more patients with insulin resistance and increased Framingham risk scores and are more useful than the definitions that require measurement of insulin levels (WHO and EGIR.

  5. A unique automation platform for measuring low level radioactivity in metabolite identification studies.

    Directory of Open Access Journals (Sweden)

    Joel Krauser

    Full Text Available Generation and interpretation of biotransformation data on drugs, i.e. identification of physiologically relevant metabolites, defining metabolic pathways and elucidation of metabolite structures, have become increasingly important to the drug development process. Profiling using (14C or (3H radiolabel is defined as the chromatographic separation and quantification of drug-related material in a given biological sample derived from an in vitro, preclinical in vivo or clinical study. Metabolite profiling is a very time intensive activity, particularly for preclinical in vivo or clinical studies which have defined limitations on radiation burden and exposure levels. A clear gap exists for certain studies which do not require specialized high volume automation technologies, yet these studies would still clearly benefit from automation. Use of radiolabeled compounds in preclinical and clinical ADME studies, specifically for metabolite profiling and identification are a very good example. The current lack of automation for measuring low level radioactivity in metabolite profiling requires substantial capacity, personal attention and resources from laboratory scientists. To help address these challenges and improve efficiency, we have innovated, developed and implemented a novel and flexible automation platform that integrates a robotic plate handling platform, HPLC or UPLC system, mass spectrometer and an automated fraction collector.

  6. A Unique Automation Platform for Measuring Low Level Radioactivity in Metabolite Identification Studies

    Science.gov (United States)

    Krauser, Joel; Walles, Markus; Wolf, Thierry; Graf, Daniel; Swart, Piet

    2012-01-01

    Generation and interpretation of biotransformation data on drugs, i.e. identification of physiologically relevant metabolites, defining metabolic pathways and elucidation of metabolite structures, have become increasingly important to the drug development process. Profiling using 14C or 3H radiolabel is defined as the chromatographic separation and quantification of drug-related material in a given biological sample derived from an in vitro, preclinical in vivo or clinical study. Metabolite profiling is a very time intensive activity, particularly for preclinical in vivo or clinical studies which have defined limitations on radiation burden and exposure levels. A clear gap exists for certain studies which do not require specialized high volume automation technologies, yet these studies would still clearly benefit from automation. Use of radiolabeled compounds in preclinical and clinical ADME studies, specifically for metabolite profiling and identification are a very good example. The current lack of automation for measuring low level radioactivity in metabolite profiling requires substantial capacity, personal attention and resources from laboratory scientists. To help address these challenges and improve efficiency, we have innovated, developed and implemented a novel and flexible automation platform that integrates a robotic plate handling platform, HPLC or UPLC system, mass spectrometer and an automated fraction collector. PMID:22723932

  7. A unique automation platform for measuring low level radioactivity in metabolite identification studies.

    Science.gov (United States)

    Krauser, Joel; Walles, Markus; Wolf, Thierry; Graf, Daniel; Swart, Piet

    2012-01-01

    Generation and interpretation of biotransformation data on drugs, i.e. identification of physiologically relevant metabolites, defining metabolic pathways and elucidation of metabolite structures, have become increasingly important to the drug development process. Profiling using (14)C or (3)H radiolabel is defined as the chromatographic separation and quantification of drug-related material in a given biological sample derived from an in vitro, preclinical in vivo or clinical study. Metabolite profiling is a very time intensive activity, particularly for preclinical in vivo or clinical studies which have defined limitations on radiation burden and exposure levels. A clear gap exists for certain studies which do not require specialized high volume automation technologies, yet these studies would still clearly benefit from automation. Use of radiolabeled compounds in preclinical and clinical ADME studies, specifically for metabolite profiling and identification are a very good example. The current lack of automation for measuring low level radioactivity in metabolite profiling requires substantial capacity, personal attention and resources from laboratory scientists. To help address these challenges and improve efficiency, we have innovated, developed and implemented a novel and flexible automation platform that integrates a robotic plate handling platform, HPLC or UPLC system, mass spectrometer and an automated fraction collector.

  8. Modelling Simple Experimental Platform for In Vitro Study of Drug Elution from Drug Eluting Stents (DES)

    Science.gov (United States)

    Kalachev, L. V.

    2016-06-01

    We present a simple model of experimental setup for in vitro study of drug release from drug eluting stents and drug propagation in artificial tissue samples representing blood vessels. The model is further reduced using the assumption on vastly different characteristic diffusion times in the stent coating and in the artificial tissue. The model is used to derive a relationship between the times at which the measurements have to be taken for two experimental platforms, with corresponding artificial tissue samples made of different materials with different drug diffusion coefficients, to properly compare the drug release characteristics of drug eluting stents.

  9. Simulation platform developed to study and identify critical cases in a future smart grid

    DEFF Research Database (Denmark)

    Mihet-Popa, Lucian; Zong, Yi; You, Shi

    2016-01-01

    This paper proposes a simulation platform developed to study and identify critical cases in a Smart Grid. A distribution network with different Distributed Energy Resources (DER) components, connected along the feeders, is analyzed, having the objective to identify limitations of existing...... simulation and planning tools, with a particular objective on the challenges faced by the introduction of Smart Grid technologies. Another important issue of the paper is to identify critical load cases, as well as the voltage variations with the highest potential, able to implement the grid model...

  10. Zero-gravity cloud physics laboratory: Experiment program definition and preliminary laboratory concept studies

    Science.gov (United States)

    Eaton, L. R.; Greco, E. V.

    1973-01-01

    The experiment program definition and preliminary laboratory concept studies on the zero G cloud physics laboratory are reported. This program involves the definition and development of an atmospheric cloud physics laboratory and the selection and delineations of a set of candidate experiments that must utilize the unique environment of zero gravity or near zero gravity.

  11. Definitions of Physical Concepts: A Study of Physics Teachers' Knowledge and Views. Research Report

    Science.gov (United States)

    Galili, Igal; Lehavi, Yaron

    2006-01-01

    A study was made of the ability of a population of high-school physics teachers to define physics concepts and of their views regarding the importance of such definitions. It was found possible to arrange the definitions accumulated in categories, and the classification so obtained was consonant with that of the philosophy of science. Although the…

  12. Ambulatory EEG NeuroMonitor platform for engagement studies of children with development delays

    Science.gov (United States)

    Mahajan, Ruhi; Consul-Pacareu, Sergi; Abusaud, Mohammed; Sahadat, Md N.; Morshed, Bashir I.

    2013-05-01

    Engagement monitoring is crucial in many clinical and therapy applications such as early learning preschool classes for children with developmental delays including autism spectrum disorder (ASD), attention-deficit hyperactivity disorder (ADHD), or cerebral palsy; as it is challenging for the instructors to evaluate the individual responses of these children to determine the effectiveness of the teaching strategies due to the diverse and unique need of each child who might have difficulty in verbal or behavioral communication. This paper presents an ambulatory scalp electroencephalogram (EEG) NeuroMonitor platform to study brain engagement activities in natural settings. The developed platform is miniature (size: 2.2" x 0.8" x 0.36", weight: 41.8 gm with 800 mAh Li-ion battery and 3 snap leads) and low-power (active mode: 32 mA low power mode: under 5mA) with 2 channels (Fp1, Fp2) to record prefrontal cortex activities of the subject in natural settings while concealed within a headband. The signals from the electrodes are amplified with a low-power instrumentation amplifier; notch filtered (fc = 60Hz), then band-passed by a 2nd-order Chebyshev-I low-pass filter cascaded with a 2nd-order low-pass (fc = 125Hz). A PSoC ADC (16-bit, 256 sps) samples this filtered signal, and can either transmit it through a Class-2 Bluetooth transceiver to a remote station for real-time analysis or store it in a microSD card for offline processing. This platform is currently being evaluated to capture data in the classroom settings for engagement monitoring of children, aimed to study the effectiveness of various teaching strategies that will allow the development of personalized classroom curriculum for children with developmental delays.

  13. Modern sediments and Pleistocene reefs from isolated carbonate platforms (Iles Eparses, SW Indian Ocean): A preliminary study

    Science.gov (United States)

    Jorry, Stéphan J.; Camoin, Gilbert F.; Jouet, Gwénaël; Roy, Pascal Le; Vella, Claude; Courgeon, Simon; Prat, Sophie; Fontanier, Christophe; Paumard, Victorien; Boulle, Julien; Caline, Bruno; Borgomano, Jean

    2016-04-01

    Isolated carbonate platforms occur throughout the geologic record, from Archean to present. Although the respective roles of tectonics, sediment supply and sea-level changes in the stratigraphical architecture of these systems are relatively well constrained, the details of the nature and controls on the variability of sedimentological patterns between and within individual geomorphologic units on platforms have been barely investigated. This study aims at describing and comparing geomorphological and sedimentological features of surficial sediments and fossil reefs from three isolated carbonate platforms located in the SW Indian Ocean (Glorieuses, Juan de Nova and Europa). These carbonate platforms are relatively small and lack continuous reef margins, which have developed only on windward sides. Field observations, petrographic characterization and grain-size analyses are used to illustrate the spatial patterns of sediment accumulation on these platforms. The internal parts of both Glorieuses and Juan de Nova platforms are blanketed by sand dunes with medium to coarse sands with numerous reef pinnacles. Skeletal components including coral, green algae, and benthic foraminifera fragments prevail in these sediments. Europa platform exhibits a similar skeletal assemblage dominated by coral fragments, with the absence of wave-driven sedimentary bodies. Fossil reefs from the Last interglacial (125,000 years BP) occur on the three platforms. At Glorieuses, a succession of drowned terraces detected on seismic lines is interpreted as reflecting the last deglacial sea-level rise initiated 20,000 years ago. These findings highlight the high potential of these platforms to study past sea-level changes and the related reef response, which remain poorly documented in the SW Indian Ocean.

  14. Competing Definitions of Schizophrenia: What Can Be Learned From Polydiagnostic Studies?

    DEFF Research Database (Denmark)

    Jansson, Lennart Bertil; Parnas, Josef

    2007-01-01

    not a product of explicit conceptual analyses and empirical studies but defined through consensus with the purpose of improving reliability. The validity status of current definitions and of their predecessors remains unclear. The so-called "polydiagnostic approach" applies different definitions of a disorder...... to the same patient sample in order to compare these definitions on potential validity indicators. We reviewed 92 polydiagnostic sz studies published since the early 1970s. Different sz definitions show a considerable variation concerning frequency, concordance, reliability, outcome, and other validity...... measures. The DSM-IV and the ICD-10 show moderate reliability but both definitions appear weak in terms of concurrent validity, eg, with respect to an aggregation of a priori important features. The first-rank symptoms of Schneider are not associated with family history of sz or with prediction of poor...

  15. Competing Definitions of Schizophrenia: What Can Be Learned From Polydiagnostic Studies?

    DEFF Research Database (Denmark)

    Jansson, Lennart Bertil; Parnas, Josef

    2006-01-01

    not a product of explicit conceptual analyses and empirical studies but defined through consensus with the purpose of improving reliability. The validity status of current definitions and of their predecessors remains unclear. The so-called "polydiagnostic approach" applies different definitions of a disorder...... to the same patient sample in order to compare these definitions on potential validity indicators. We reviewed 92 polydiagnostic sz studies published since the early 1970s. Different sz definitions show a considerable variation concerning frequency, concordance, reliability, outcome, and other validity...... measures. The DSM-IV and the ICD-10 show moderate reliability but both definitions appear weak in terms of concurrent validity, eg, with respect to an aggregation of a priori important features. The first-rank symptoms of Schneider are not associated with family history of sz or with prediction of poor...

  16. Multi-platform metabolomics assays for human lung lavage fluids in an air pollution exposure study.

    Science.gov (United States)

    Surowiec, Izabella; Karimpour, Masoumeh; Gouveia-Figueira, Sandra; Wu, Junfang; Unosson, Jon; Bosson, Jenny A; Blomberg, Anders; Pourazar, Jamshid; Sandström, Thomas; Behndig, Annelie F; Trygg, Johan; Nording, Malin L

    2016-07-01

    Metabolomics protocols are used to comprehensively characterize the metabolite content of biological samples by exploiting cutting-edge analytical platforms, such as gas chromatography (GC) or liquid chromatography (LC) coupled to mass spectrometry (MS) assays, as well as nuclear magnetic resonance (NMR) assays. We have developed novel sample preparation procedures combined with GC-MS, LC-MS, and NMR metabolomics profiling for analyzing bronchial wash (BW) and bronchoalveolar lavage (BAL) fluid from 15 healthy volunteers following exposure to biodiesel exhaust and filtered air. Our aim was to investigate the responsiveness of metabolite profiles in the human lung to air pollution exposure derived from combustion of biofuels, such as rapeseed methyl ester biodiesel, which are increasingly being promoted as alternatives to conventional fossil fuels. Our multi-platform approach enabled us to detect the greatest number of unique metabolites yet reported in BW and BAL fluid (82 in total). All of the metabolomics assays indicated that the metabolite profiles of the BW and BAL fluids differed appreciably, with 46 metabolites showing significantly different levels in the corresponding lung compartments. Furthermore, the GC-MS assay revealed an effect of biodiesel exhaust exposure on the levels of 1-monostearylglycerol, sucrose, inosine, nonanoic acid, and ethanolamine (in BAL) and pentadecanoic acid (in BW), whereas the LC-MS assay indicated a shift in the levels of niacinamide (in BAL). The NMR assay only identified lactic acid (in BW) as being responsive to biodiesel exhaust exposure. Our findings demonstrate that the proposed multi-platform approach is useful for wide metabolomics screening of BW and BAL fluids and can facilitate elucidation of metabolites responsive to biodiesel exhaust exposure. Graphical Abstract Graphical abstract illustrating the study workflow. NMR Nuclear Magnetic Resonance, LC-TOFMS Liquid chromatography-Time Of Flight Mass Spectrometry, GC Gas

  17. Platform-based production development

    DEFF Research Database (Denmark)

    Bossen, Jacob; Brunoe, Thomas Ditlev; Nielsen, Kjeld

    2015-01-01

    Platforms as a means for applying modular thinking in product development is relatively well studied, but platforms in the production system has until now not been given much attention. With the emerging concept of platform-based co-development the importance of production platforms is though...... indisputable. This paper presents state-of-the-art literature on platform research related to production platforms and investigates gaps in the literature. The paper concludes on findings by proposing future research directions....

  18. Engineered neuronal circuits: A new platform for studying the roleof modular topology

    Directory of Open Access Journals (Sweden)

    Mark eShein-Idelson

    2011-09-01

    Full Text Available Neuron-glia cultures serve as a valuable model system for exploring the bio-molecular activity of single cells. Since neurons in culture can be conveniently recorded with great fidelity from many sites simultaneously, it has long been suggested that uniform cultured neurons may also be used to investigate network-level mechanisms pertinent to information processing, activity propagation, memory and learning. But how much of the functionality of neural circuits can be retained in-vitro remains an open question. Recent studies utilizing patterned networks suggest that they provide a most useful platform to address fundamental questions in neuroscience. Here we review recent efforts in the realm of patterned networks' activity investigations. We give a brief overview of the patterning methods and experimental approaches commonly employed in the field, and summarize the main results reported in the literature. The general picture that emerges from these reports indicates that patterned networks with uniform connectivity do not exhibit unique activity patterns. Rather, their activity is very similar to that of unpatterned uniform networks. However, by breaking the connectivity homogeneity, using a modular architecture, it is possible to introduce pronounced topology-related gating and delay effects. These findings suggest that patterned cultured networks may serve as a new platform for studying the role of modularity in neuronal circuits.

  19. Bone platform switching: a retrospective study on the slope of reverse conical neck.

    Science.gov (United States)

    Danza, Matteo; Riccardo, Guidi; Carinci, Francesco

    2010-01-01

    Bone platform switching results in an inward bone ring in the coronal part of an implant that is in continuity with the alveolar bone crest. Bone platform switching is achieved by using a dental implant with a reverse conical neck (RCN). A retrospective study was performed to determine the impact of RCN on crestal bone remodeling (CBR). A series of 191 implants with the same morphology, but three slopes of RCN, were evaluated. Lost implants and CBR around implants still in place at the end of the follow-up were considered to investigate those variables potentially associated with the clinical outcome. Radiographic examinations were performed for each implant before surgery and at the end of the follow-up to detect the degree of CBR. Time-dependent cutoff values were used to select implants with higher CBR. These implants were considered unsuccessful. The Kaplan-Meier algorithm was applied to detect those variables potentially associated with the clinical outcome (ie, lost implants or implants with higher CBR). Only 5 of 191 implants were lost (survival rate 97.4%). No statistical differences were detected among the studied variables by using lost implants. Although no statistical differences were detected among the three types of implants, the data seem to indicate a correlation between CBR and the slope of the RCN, with a better outcome for implants with a more angulated RCN.

  20. A Robotic Platform to Study the Foreflipper of the California Sea Lion.

    Science.gov (United States)

    Kulkarni, Aditya A; Patel, Rahi K; Friedman, Chen; Leftwich, Megan C

    2017-01-10

    The California sea lion (Zalophus californianus), is an agile and powerful swimmer. Unlike many successful swimmers (dolphins, tuna), they generate most of their thrust with their large foreflippers. This protocol describes a robotic platform designed to study the hydrodynamic performance of the swimming California sea lion (Zalophus californianus). The robot is a model of the animal's foreflipper that is actuated by motors to replicate the motion of its propulsive stroke (the 'clap'). The kinematics of the sea lion's propulsive stroke are extracted from video data of unmarked, non-research sea lions at the Smithsonian Zoological Park (SNZ). Those data form the basis of the actuation motion of the robotic flipper presented here. The geometry of the robotic flipper is based a on high-resolution laser scan of a foreflipper of an adult female sea lion, scaled to about 60% of the full-scale flipper. The articulated model has three joints, mimicking the elbow, wrist and knuckle joint of the sea lion foreflipper. The robotic platform matches dynamics properties-Reynolds number and tip speed-of the animal when accelerating from rest. The robotic flipper can be used to determine the performance (forces and torques) and resulting flowfields.

  1. Study on Constructing an Education Platform for Innovation and Entrepreneurship of University Student

    Directory of Open Access Journals (Sweden)

    Xiaowei Jiang

    2015-04-01

    Full Text Available To solve the problems existing in innovation and entrepreneurship education in colleges and universities of China, a series of effective approaches are proposed, so as to construct an education platform for innovation and entrepreneurship which adapts to market demand and could promote the development of comprehensive quality. In this study, the problems existing in innovation and entrepreneurship education in our colleges and universities are analyzed in detail. Then a series of approaches are proposed including establishing the scientific curriculum system for innovation and entrepreneurship, establishing practice base for innovation and entrepreneurship, improving the professional level of teaching staff for innovative and entrepreneurship, creating a cultural atmosphere and strengthening the innovative consciousness and entrepreneurial spirit, establishing a sound reward systems of innovation and entrepreneurship and building a network platform for innovation and entrepreneurship, in order to carry out innovation and entrepreneurship education preferably, cultivate innovative quality and entrepreneurial ability of students and alleviate the severe employment pressure in our country at present.

  2. A Study on Immersion of Hand Interaction for Mobile Platform Virtual Reality Contents

    Directory of Open Access Journals (Sweden)

    Seunghun Han

    2017-02-01

    Full Text Available This study proposes gaze-based hand interaction, which is helpful for improving the user’s immersion in the production process of virtual reality content for the mobile platform, and analyzes efficiency through an experiment using a questionnaire. First, three-dimensional interactive content is produced for use in the proposed interaction experiment while presenting an experiential environment that gives users a high sense of immersion in the mobile virtual reality environment. This is designed to induce the tension and concentration of users in line with the immersive virtual reality environment. Additionally, a hand interaction method based on gaze—which is mainly used for the entry of mobile virtual reality content—is proposed as a design method for immersive mobile virtual reality environment. The user satisfaction level of the immersive environment provided by the proposed gaze-based hand interaction is analyzed through experiments in comparison with the general method that uses gaze only. Furthermore, detailed analysis is conducted by dividing the effects of the proposed interaction method on user’s psychology into positive factors such as immersion and interest and negative factors such as virtual reality (VR sickness and dizziness. In this process, a new direction is proposed for improving the immersion of users in the production of mobile platform virtual reality content.

  3. Low-cost microcontroller platform for studying lymphatic biomechanics in vitro.

    Science.gov (United States)

    Kornuta, Jeffrey A; Nipper, Matthew E; Dixon, J Brandon

    2013-01-04

    The pumping innate to collecting lymphatic vessels routinely exposes the endothelium to oscillatory wall shear stress and other dynamic forces. However, studying the mechanical sensitivity of the lymphatic endothelium remains a difficult task due to limitations of commercial or custom systems to apply a variety of time-varying stresses in vitro. Current biomechanical in vitro testing devices are very expensive, limited in capability, or highly complex; rendering them largely inaccessible to the endothelial cell biology community. To address these shortcomings, the authors propose a reliable, low-cost platform for augmenting the capabilities of commercially available pumps to produce a wide variety of flow rate waveforms. In particular, the Arduino Uno, a microcontroller development board, is used to provide open-loop control of a digital peristaltic pump using precisely timed serial commands. In addition, the flexibility of this platform is further demonstrated through its support of a custom-built cell-straining device capable of producing oscillatory strains with varying amplitudes and frequencies. Hence, this microcontroller development board is shown to be an inexpensive, precise, and easy-to-use tool for supplementing in vitro assays to quantify the effects of biomechanical forces on lymphatic endothelial cells. Copyright © 2012 Elsevier Ltd. All rights reserved.

  4. Comparative study of the sources of exergy destruction on four North Sea oil and gas platforms

    DEFF Research Database (Denmark)

    Voldsund, Mari; Nguyen, Tuong-Van; Elmegaard, Brian

    2013-01-01

    In this paper, the oil and gas processing systems on four North Sea offshore platforms are reported and discussed. Sources of exergy destruction are identified and the findings for the different platforms are compared. Different platforms have different working conditions, such as reservoir...... the lifetime of an oil field, and to maintain the efficiency of an offshore platform is therefore challenging. In practice, variations in the process feed result in the use of control strategies such as anti-surge recycling, which cause additional power consumption and exergy destruction. For all four...... platforms, more than 27% of the total exergy destruction takes place in the gas treatment section while at least 16% occurs in the production manifold systems. The exact potential for energy savings and for enhancing system performances differ across offshore platforms. However, the results indicate...

  5. X-ray photoelectron spectroscopy study of pyrolytically coated graphite platforms submitted to simulated electrothermal atomic absorption spectrometry conditions

    Energy Technology Data Exchange (ETDEWEB)

    Ruiz, Frine [Laboratorio de Quimica Analitica, Centro de Quimica, Instituto Venezolano de Investigaciones Cientificas, IVIC, Apartado Postal 21827, Caracas 1020-A (Venezuela); Benzo, Zully [Laboratorio de Quimica Analitica, Centro de Quimica, Instituto Venezolano de Investigaciones Cientificas, IVIC, Apartado Postal 21827, Caracas 1020-A (Venezuela); Quintal, Manuelita [Laboratorio de Quimica Analitica, Centro de Quimica, Instituto Venezolano de Investigaciones Cientificas, IVIC, Apartado Postal 21827, Caracas 1020-A (Venezuela); Garaboto, Angel [Laboratorio de Quimica Analitica, Centro de Quimica, Instituto Venezolano de Investigaciones Cientificas, IVIC, Apartado Postal 21827, Caracas 1020-A (Venezuela); Albornoz, Alberto [Laboratorio de Fisicoquimica de Superficies, Centro de Quimica, Instituto Venezolano de Investigaciones Cientificas, IVIC, Apartado Postal 21827, Caracas 1020-A (Venezuela); Brito, Joaquin L. [Laboratorio de Fisicoquimica de Superficies, Centro de Quimica, Instituto Venezolano de Investigaciones Cientificas, IVIC, Apartado Postal 21827, Caracas 1020-A (Venezuela)]. E-mail: joabrito@ivic.ve

    2006-10-15

    The present work is part of an ongoing project aiming to a better understanding of the mechanisms of atomization on graphite furnace platforms used for electrothermal atomic absorption spectrometry (ETAAS). It reports the study of unused pyrolytic graphite coated platforms of commercial origin, as well as platforms thermally or thermo-chemically treated under simulated ETAAS analysis conditions. X-ray photoelectron spectroscopy (XPS) was employed to study the elements present at the surfaces of the platforms. New, unused platforms showed the presence of molybdenum, of unknown origin, in concentrations up to 1 at.%. Species in two different oxidations states (Mo{sup 6+} and Mo{sup 2+}) were detected by analyzing the Mo 3d spectral region with high resolution XPS. The analysis of the C 1s region demonstrated the presence of several signals, one of these at 283.3 eV related to the presence of Mo carbide. The O 1s region showed also various peaks, including a signal that can be attributed to the presence of MoO{sub 3}. Some carbon and oxygen signals were consistent with the presence of C=O and C-O- (probably C-OH) groups on the platforms surfaces. Upon thermal treatment up to 2900 deg. C, the intensity of the Mo signal decreased, but peaks due to Mo oxides (Mo{sup 6+} and Mo{sup 5+}) and carbide (Mo{sup 2+}) were still apparent. Thermo-chemical treatment with 3 vol.% HCl solutions and heating up to 2900 deg. C resulted in further diminution of the Mo signal, with complete disappearance of Mo carbide species. Depth profiling of unused platforms by Ar{sup +} ion etching at increasing time periods demonstrated that, upon removal of several layers of carbonaceous material, the Mo signal disappears suggesting that this contamination is present only at the surface of the pyrolytic graphite platform.

  6. Consensus on the Definition of Advanced Parkinson's Disease: A Neurologists-Based Delphi Study (CEPA Study)

    Science.gov (United States)

    Kulisevsky, Jaime; Tolosa, Eduardo S.

    2017-01-01

    To date, no consensus exists on the key factors for diagnosing advanced Parkinson disease (APD). To obtain consensus on the definition of APD, we performed a prospective, multicenter, Spanish nationwide, 3-round Delphi study (CEPA study). An ad hoc questionnaire was designed with 33 questions concerning the relevance of several clinical features for APD diagnosis. In the first-round, 240 neurologists of the Spanish Movement Disorders Group participated in the study. The results obtained were incorporated into the questionnaire and both, results and questionnaire, were sent out to and fulfilled by 26 experts in Movement Disorders. Review of results from the second-round led to a classification of symptoms as indicative of “definitive,” “probable,” and “possible” APD. This classification was confirmed by 149 previous participating neurologists in a third-round, where 92% completely or very much agreed with the classification. Definitive symptoms of APD included disability requiring help for the activities of daily living, presence of motor fluctuations with limitations to perform basic activities of daily living without help, severe dysphagia, recurrent falls, and dementia. These results will help neurologists to identify some key factors in APD diagnosis, thus allowing users to categorize the patients for a homogeneous recognition of this condition. PMID:28239501

  7. Nanodiamonds Used as a Platform for Studying Noncovalent Interaction by MALDI-MS

    Institute of Scientific and Technical Information of China (English)

    KONG,Xiang-Lei

    2008-01-01

    As a new, fast and easy-preformed method, nanodiamond has been used to study noncovalent interaction by MALDI-MS. The diamonds covered with "bait analyte" were added into the solution of "fish analyte", and then separated with nanodiamonds by centrifugation and washed by water for final MALDI-MS analysis. At the same time, mass spectrum of supernatant can also provide useful information by comparison with that of original solution without treatment by diamonds. This platform can be used to study inter-molecular noncovalent interaction and can further find its application to selectively enhanced MALDI-MS analysis, as the example of PL-coated nanodiamonds used in mass analysis of phosphopeptides.

  8. A study of lock-free based concurrent garbage collectors for multicore platform.

    Science.gov (United States)

    Wu, Hao; Ji, Zhen-Zhou

    2014-01-01

    Concurrent garbage collectors (CGC) have recently obtained extensive concern on multicore platform. Excellent designed CGC can improve the efficiency of runtime systems by exploring the full potential processing resources of multicore computers. Two major performance critical components for designing CGC are studied in this paper, stack scanning and heap compaction. Since the lock-based algorithms do not scale well, we present a lock-free solution for constructing a highly concurrent garbage collector. We adopt CAS/MCAS synchronization primitives to guarantee that the programs will never be blocked by the collector thread while the garbage collection process is ongoing. The evaluation results of this study demonstrate that our approach achieves competitive performance.

  9. A Study of Lock-Free Based Concurrent Garbage Collectors for Multicore Platform

    Directory of Open Access Journals (Sweden)

    Hao Wu

    2014-01-01

    Full Text Available Concurrent garbage collectors (CGC have recently obtained extensive concern on multicore platform. Excellent designed CGC can improve the efficiency of runtime systems by exploring the full potential processing resources of multicore computers. Two major performance critical components for designing CGC are studied in this paper, stack scanning and heap compaction. Since the lock-based algorithms do not scale well, we present a lock-free solution for constructing a highly concurrent garbage collector. We adopt CAS/MCAS synchronization primitives to guarantee that the programs will never be blocked by the collector thread while the garbage collection process is ongoing. The evaluation results of this study demonstrate that our approach achieves competitive performance.

  10. A study on the seismic fortification level of offshore platform in Bohai Sea of China

    Science.gov (United States)

    Lu, Y.

    2010-12-01

    The Chinese sea areas are important places of offshore petroleum resources, and at the same time they are also seismically active regions. Fixed offshore platforms (OPs) are the fundamental facilities for marine resource exploitation, and usually situated in a complex and severe environment as having to endure many environmental loads in their life span, therefore, the damage to their structures may result in serious disasters. Among these environmental loads the seismic load has tremendous destructive effect and is not predictable. In case of not overly severe wind, wave and current, seismic resistance dominates the strength design of platforms. Furthermore, strong earthquakes have occurred recently or in the history of all the sea areas of oil/gas exploitation in China. Therefore, seismic design of fixed OPs is a very important issue. With the development of marine exploration and earthquake researches in the sea area, extensive studies on the seismotectonic environment and seismicity characteristics of the sea areas of China have been performed, meanwhile, more and more experience and data have been accumulated from OP design practice, which laid a foundation for studying and establishing the seismic design standard of OPs. This paper first gives an overall understanding of the seismic environment of the sea areas of China, then taking the Bohai Sea seismic risk study as an example, introducing a so-called shape factor K to characterize the seismic risk distribution in sub-regions of the Bohai Sea. Based on the seismic design ground motions for 46 platforms in Bohai Sea, a statistic analysis was performed for different peak ground acceleration (PGA) ratios at two different probability levels. In accordance with the two-stage design method, a scheme of two seismic design levels is proposed, and two seismic design objectives are established respectively for the strength level earthquake and ductility level earthquake. By analogy with and comparison to the Chinese

  11. What level of accuracy is achievable for preclinical dose painting studies on a clinical irradiation platform?

    Science.gov (United States)

    Trani, Daniela; Reniers, Brigitte; Persoon, Lucas; Podesta, Mark; Nalbantov, Georgi; Leijenaar, Ralph T H; Granzier, Marlies; Yaromina, Ala; Dubois, Ludwig; Verhaegen, Frank; Lambin, Philippe

    2015-05-01

    Advancements made over the past decades in both molecular imaging and radiotherapy planning and delivery have enabled studies that explore the efficacy of heterogeneous radiation treatment ("dose painting") of solid cancers based on biological information provided by different imaging modalities. In addition to clinical trials, preclinical studies may help contribute to identifying promising dose painting strategies. The goal of this current study was twofold: to develop a reproducible positioning and set-up verification protocol for a rat tumor model to be imaged and treated on a clinical platform, and to assess the dosimetric accuracy of dose planning and delivery for both uniform and positron emission tomography-computed tomography (PET-CT) based heterogeneous dose distributions. We employed a syngeneic rat rhabdomyosarcoma model, which was irradiated by volumetric modulated arc therapy (VMAT) with uniform or heterogeneous 6 MV photon dose distributions. Mean dose to the gross tumor volume (GTV) as a whole was kept at 12 Gy for all treatment arms. For the nonuniform plans, the dose was redistributed to treat the 30% of the GTV representing the biological target volume (BTV) with a dose 40% higher than the rest of the GTV (GTV - BTV) (~15 Gy was delivered to the BTV vs. ~10.7 Gy was delivered to the GTV - BTV). Cone beam computed tomography (CBCT) images acquired for each rat prior to irradiation were used to correctly reposition the tumor and calculate the delivered 3D dose. Film quality assurance was performed using a water-equivalent rat phantom. A comparison between CT or CBCT doses and film measurements resulted in passing rates >98% with a gamma criterion of 3%/2 mm using 2D dose images. Moreover, between the CT and CBCT calculated doses for both uniform and heterogeneous plans, we observed maximum differences of <2% for mean dose to the tumor and mean dose to the biological target volumes. In conclusion, we have developed a robust method for dose painting

  12. Study Finds Ebola Treatment ZMapp Holds Promise, Although Results Not Definitive

    Science.gov (United States)

    ... News Release Thursday, October 13, 2016 Study finds Ebola treatment ZMapp holds promise, although results not definitive ... emergency. A clinical trial to evaluate the experimental Ebola treatment ZMapp found it to be safe and ...

  13. The Definition and Treatment of Bulimarexia in College Women--A Pilot Study.

    Science.gov (United States)

    Boskind-Ledahl, Marlene; White, William C., Jr.

    1978-01-01

    A study of college women suffering from bulimarexia, a cyclical eating disorder characterized by bingeing/purging behaviors and abnormally low self-esteem, indicates the importance of sociocultural factors in female role definition. (JMF)

  14. The Definition and Treatment of Bulimarexia in College Women--A Pilot Study.

    Science.gov (United States)

    Boskind-Ledahl, Marlene; White, William C., Jr.

    1978-01-01

    A study of college women suffering from bulimarexia, a cyclical eating disorder characterized by bingeing/purging behaviors and abnormally low self-esteem, indicates the importance of sociocultural factors in female role definition. (JMF)

  15. College Students' Definitions of Intimate Partner Violence: A Comparative Study of Three Chinese Societies.

    Science.gov (United States)

    Jiao, Yanpeng; Sun, Ivan Y; Farmer, Ashley K; Lin, Kai

    2016-04-01

    Although a large number of studies have been conducted worldwide to examine various aspects of intimate partner violence (IPV), comparative study of people's views on such violence in Chinese societies has been scarce. Using survey data collected from more than 850 college students in China, Hong Kong, and Taiwan, this study specifically assessed the impact of attitudes toward gender role and violence, personal and vicarious experience, demographic characteristics, and locality on students' definitions of IPV. The Taiwanese students were most likely to define a broader range of abusive behavior as IPV, followed by Hong Kong and Beijing students. Gender role and violence attitudes appeared to be most important predictors of IPV definitions. College students who supported the notion of male dominance were more likely to have a narrower definition of IPV, whereas those who viewed domestic violence as crime were more inclined to have a broader definition of IPV. Implications for future research and policy were discussed.

  16. Using Unmanned Underwater Vehicles as Research Platforms in Coastal Ocean Studies

    Institute of Scientific and Technical Information of China (English)

    HOU Weilin; Kendall L. Carder; David K. Costello; DU Keping; LIU Zhishen

    2003-01-01

    The advantages of using unmanned underwater vehicles in coastal ocean studies are emphasized. Two types of representative vehicles, remotely operated vehicle (ROV) and autonomous underwater vehicle (AUV) from University of South Florida, are discussed. Two individual modular sensor packages designed and tested for these platforms and field measurement results are also presented. The bottom classification and albedo package, BCAP, provides fast and accurate estimates of bottom albedos, along with other parameters such as in-water remote sensing reflectance. The real-time ocean bottom optical topographer, ROBOT, reveals high-resolution 3-dimentional bottom topography for target identification. Field data and results from recent Coastal Benthic Optical Properties field campaign, 1999 and 2000, are presented. Advantages and limitations of these vehicles and applications of modular sensor packages are compared and discussed.

  17. Advancing Translational Space Research Through Biospecimen Sharing: Amplified Impact of Studies Utilizing Analogue Space Platforms

    Science.gov (United States)

    Staten, B.; Moyer, E.; Vizir, V.; Gompf, H.; Hoban-Higgins, T.; Lewis, L.; Ronca, A.; Fuller, C. A.

    2016-01-01

    Biospecimen Sharing Programs (BSPs) have been organized by NASA Ames Research Center since the 1960s with the goal of maximizing utilization and scientific return from rare, complex and costly spaceflight experiments. BSPs involve acquiring otherwise unused biological specimens from primary space research experiments for distribution to secondary experiments. Here we describe a collaboration leveraging Ames expertise in biospecimen sharing to magnify the scientific impact of research informing astronaut health funded by the NASA Human Research Program (HRP) Human Health Countermeasures (HHC) Element. The concept expands biospecimen sharing to one-off ground-based studies utilizing analogue space platforms (e.g., Hindlimb Unloading (HLU), Artificial Gravity) for rodent experiments, thereby significantly broadening the range of research opportunities with translational relevance for protecting human health in space and on Earth.

  18. Novel portable platform for molecular detection of toxigenic Clostridium difficile in faeces: a diagnostic accuracy study.

    Science.gov (United States)

    Hirvonen, J J; Matero, P; Siebert, C; Kauppila, J; Vuento, R; Tuokko, H; Boisset, S

    2017-05-01

    A novel portable platform for nucleic acid amplification enables rapid detection of diarrhoea causing toxigenic Clostridium difficile directly from faeces, even in resource-limited settings. We evaluated the accuracy and precision of the new commercial molecular test system. One thousand one hundred and sixty faecal samples from patients suspected of having Clostridium difficile infection (CDI) were analysed using the Orion GenRead C. difficile test system (Orion Diagnostica Oy, Espoo, Finland) and comparative methods in three teaching hospital laboratories in Finland and France. The precision of the Orion GenRead C. difficile test system was evaluated in a reproducibility study with a set of blind-coded samples. The test system is based on a new isothermal amplification technology (Strand Invasion Based Amplification, SIBA®) and detection of the tcdB gene of C. difficile. We calculated the sensitivity, specificity, and the overall agreement according to Clinical and Laboratory Standards Institute recommendations. The overall agreement of the Orion GenRead C. difficile test when compared to the comparative methods in routine use in the participating laboratories was between 96.7% and 98.8%. In the reproducibility study; the total percent agreement between three laboratories was 99.8%. The identification of toxigenic C. difficile from faeces with the light-weight portable Orion GenRead test system was highly sensitive and specific, and the results were reproducible in the participating laboratories. This platform could enable fast and accurate molecular pathogen detection even in resource-limited or point-of-care settings.

  19. Towards a European definition for a drug shortage: a qualitative study

    Directory of Open Access Journals (Sweden)

    Elfi eDe Weerdt

    2015-10-01

    Full Text Available Background: Drug shortages are currently on the rise. In-depth investigation of the problem is necessary, however, a variety of definitions for ‘drug shortages’ are formulated in legislations, by different organisations, authorities and other initiatives. For international comparison, the underlying definition for drug shortages is important to allow appropriate interpretation of national databases and the results of scientific studies. The objective is to identify the different elements which should be considered in a uniform definition for drug shortages in the European Union and to detect the different conditions for reporting drug shortages.Methods: Definitions of drug shortages were searched in the scientific databases as well as in the grey literature. Similar topics were identified and organisations were contacted to formulate the reasoning underlying the definitions.Results: Over 20 different definitions for drug shortages were identified. A distinction is made between general definitions of drug shortages and definitions used for the reporting of drug shortages. Differences and similarities are observed in the elements within the definitions, e.g. when does a supply problem become a drug shortage, permanent and/or temporally shortages, the typology and time frame of a drug shortage. The moment a supply problem is considered as a shortage, can be defined at four levels: (i demand side, (ii supply side, (iii delivery of a drug and (iv availability of a drug. Permanent discontinuations of drugs are not always covered in definitions for drug shortages. Some definitions only consider those drugs used for the treatment of serious diseases or drugs for which no alternative is available. Different time frames were observed, varying between one day and 20 days.Conclusion: Obtaining a uniform definition for drug shortages is important as well as identifying which conditions are preferable to report drug shortages in order to facilitate

  20. A mechatronics platform to study prosthetic hand control using EMG signals.

    Science.gov (United States)

    Geethanjali, P

    2016-09-01

    . This prototype facilitated the study of various issues of pattern recognition and identified an efficient classifier, along with a feature ensemble, in the implementation of EMG controlled prosthetic hands in a laboratory setting at low-cost. This platform may help to motivate and facilitate prosthetic hand research in developing countries.

  1. Comparative study of the sources of exergy destruction on four North Sea oil and gas platforms

    DEFF Research Database (Denmark)

    Voldsund, Mari; Nguyen, Tuong-Van; Elmegaard, Brian

    2013-01-01

    In this paper, the oil and gas processing systems on four North Sea offshore platforms are reported and discussed. Sources of exergy destruction are identified and the findings for the different platforms are compared. Different platforms have different working conditions, such as reservoir...... temperatures and pressures, gas- and water-to-oil ratios in the feed, crude oil properties, product specifications and recovery strategies. These differences imply that some platforms naturally need less power for oil and gas processing than others. Reservoir properties and composition also vary over...... the lifetime of an oil field, and to maintain the efficiency of an offshore platform is therefore challenging. In practice, variations in the process feed result in the use of control strategies such as anti-surge recycling, which cause additional power consumption and exergy destruction. For all four...

  2. Study on the E-commerce platform based on the agent

    Science.gov (United States)

    Fu, Ruixue; Qin, Lishuan; Gao, Yinmin

    2011-10-01

    To solve problem of dynamic integration in e-commerce, the Multi-Agent architecture of electronic commerce platform system based on Agent and Ontology has been introduced, which includes three major types of agent, Ontology and rule collection. In this architecture, service agent and rule are used to realize the business process reengineering, the reuse of software component, and agility of the electronic commerce platform. To illustrate the architecture, a simulation work has been done and the results imply that the architecture provides a very efficient method to design and implement the flexible, distributed, open and intelligent electronic commerce platform system to solve problem of dynamic integration in ecommerce. The objective of this paper is to illustrate the architecture of electronic commerce platform system, and the approach how Agent and Ontology support the electronic commerce platform system.

  3. Human cell-based micro electrode array platform for studying neurotoxicity

    Directory of Open Access Journals (Sweden)

    Laura eYlä-Outinen

    2010-09-01

    Full Text Available At present, most of the neurotoxicological analyses are based on in vitro and in vivo models utilizing animal cells or animal models. In addition, the used in vitro models are mostly based on molecular biological end-point analyses. Thus, for neurotoxicological screening, human cell-based analysis platforms in which the functional neuronal networks responses for various neurotoxicants can be also detected real-time are highly needed. Microelectrode array (MEA is a method which enables the measurement of functional activity of neuronal cell networks in vitro for long periods of time. Here, we utilize MEA to study the neurotoxicity of methyl mercury chloride (MeHgCl, concentrations 0.5-500 nM to human embryonic stem cell (hESC-derived neuronal cell networks exhibiting spontaneous electrical activity. The neuronal cell cultures were matured on MEAs into networks expressing spontaneous spike train-like activity before exposing the cells to MeHgCl for 72 hours. MEA measurements were performed acutely and 24, 48, and 72 hours after the onset of the exposure. Finally, exposed cells were analyzed with traditional molecular biological methods for cell proliferation, cell survival, and gene and protein expression. Our results show that 500 nM MeHgCl decreases the electrical signaling and alters the pharmacologic response of hESC-derived neuronal networks in delayed manner whereas effects can not be detected with qRT-PCR, immunostainings, or proliferation measurements. Thus, we conclude that human cell-based MEA-platform is a sensitive online method for neurotoxicological screening.

  4. Canadian ethnographic study of sources and definitions of theological reflection in pastoral care and counseling.

    Science.gov (United States)

    O'Connor, Thomas St James; Meakes, Elizabeth

    2008-01-01

    What are the sources and definitions of theological reflection developed by Canadian practitioners of pastoral care and counseling? This study is part of a larger qualitative research project on theological reflection. This research reviews the literature, describes the ethnographic method, and presents the findings with a sample of 75. Main sources are sacred texts, personal experience, experiences of clients, and traditions of faith group. Definitions are meaning making, discovering the divine and discipleship with recommendations for future research listed.

  5. Comprehensive Study of the Flow Control Strategy in a Wirelessly Charged Centrifugal Microfluidic Platform with Two Rotation Axes.

    Science.gov (United States)

    Zhu, Yunzeng; Chen, Yiqi; Meng, Xiangrui; Wang, Jing; Lu, Ying; Xu, Youchun; Cheng, Jing

    2017-09-05

    Centrifugal microfluidics has been widely applied in the sample-in-answer-out systems for the analyses of nucleic acids, proteins, and small molecules. However, the inherent characteristic of unidirectional fluid propulsion limits the flexibility of these fluidic chips. Providing an extra degree of freedom to allow the unconstrained and reversible pumping of liquid is an effective strategy to address this limitation. In this study, a wirelessly charged centrifugal microfluidic platform with two rotation axes has been constructed and the flow control strategy in such platform with two degrees of freedom was comprehensively studied for the first time. Inductively coupled coils are installed on the platform to achieve wireless power transfer to the spinning stage. A micro servo motor is mounted on both sides of the stage to alter the orientation of the device around a secondary rotation axis on demand during stage rotation. The basic liquid operations on this platform, including directional transport of liquid, valving, metering, and mixing, are comprehensively studied and realized. Finally, a chip for the simultaneous determination of hexavalent chromium [Cr(VI)] and methanal in water samples is designed and tested based on the strategy presented in this paper, demonstrating the potential use of this platform for on-site environmental monitoring, food safety testing, and other life science applications.

  6. Consensus statement on injury definitions and data collection procedures for studies of injuries in rugby union.

    Science.gov (United States)

    Fuller, Colin W; Molloy, Michael G; Bagate, Christian; Bahr, Roald; Brooks, John H M; Donson, Hilton; Kemp, Simon P T; McCrory, Paul; McIntosh, Andrew S; Meeuwisse, Willem H; Quarrie, Kenneth L; Raftery, Martin; Wiley, Preston

    2007-05-01

    Wide variations in the definitions and methodologies used for studies of injuries in rugby union have created inconsistencies in reported data and made interstudy comparisons of results difficult. The International Rugby Board established a Rugby Injury Consensus Group (RICG) to reach an agreement on the appropriate definitions and methodologies to standardise the recording of injuries and reporting of studies in rugby union. The RICG reviewed the consensus definitions and methodologies previously published for football (soccer) at a meeting in Dublin in order to assess their suitability for and application to rugby union. Following this meeting, iterative draft statements were prepared and circulated to members of the RICG for comment; a follow-up meeting was arranged in Dublin, at which time all definitions and procedures were finalised. At this stage, all authors confirmed their agreement with the consensus statement. The agreed document was presented to and approved by the International Rugby Board Council. Agreement was reached on definitions for injury, recurrent injury, non-fatal catastrophic injury, and training and match exposures, together with criteria for classifying injuries in terms of severity, location, type, diagnosis and causation. The definitions and methodology presented in this consensus statement for rugby union are similar to those proposed for football. Adoption of the proposals presented in this consensus statement should ensure that more consistent and comparable results will be obtained from studies of injuries within rugby union.

  7. Consensus statement on injury definitions and data collection procedures for studies of injuries in rugby union

    Science.gov (United States)

    Fuller, Colin W; Molloy, Michael G; Bagate, Christian; Bahr, Roald; Brooks, John H M; Donson, Hilton; Kemp, Simon P T; McCrory, Paul; McIntosh, Andrew S; Meeuwisse, Willem H; Quarrie, Kenneth L; Raftery, Martin; Wiley, Preston

    2007-01-01

    Wide variations in the definitions and methodologies used for studies of injuries in rugby union have created inconsistencies in reported data and made interstudy comparisons of results difficult. The International Rugby Board established a Rugby Injury Consensus Group (RICG) to reach an agreement on the appropriate definitions and methodologies to standardise the recording of injuries and reporting of studies in rugby union. The RICG reviewed the consensus definitions and methodologies previously published for football (soccer) at a meeting in Dublin in order to assess their suitability for and application to rugby union. Following this meeting, iterative draft statements were prepared and circulated to members of the RICG for comment; a follow‐up meeting was arranged in Dublin, at which time all definitions and procedures were finalised. At this stage, all authors confirmed their agreement with the consensus statement. The agreed document was presented to and approved by the International Rugby Board Council. Agreement was reached on definitions for injury, recurrent injury, non‐fatal catastrophic injury, and training and match exposures, together with criteria for classifying injuries in terms of severity, location, type, diagnosis and causation. The definitions and methodology presented in this consensus statement for rugby union are similar to those proposed for football. Adoption of the proposals presented in this consensus statement should ensure that more consistent and comparable results will be obtained from studies of injuries within rugby union. PMID:17452684

  8. A study of wave forces on an offshore platform by direct CFD and Morison equation

    Directory of Open Access Journals (Sweden)

    Zhang D.

    2015-01-01

    The next step is the presentation of 3D multiphase RANS simulation of the wind-turbine platform in single-harmonic regular waves. Simulation results from full 3D simulation will be compared to the results from Morison’s equation. We are motivated by the challenges of a floating platform which has complex underwater geometry (e.g. tethered semi-submersible. In cases like this, our hypothesis is that Morison’s equation will result in inaccurate prediction of forces, due to the limitations of 2D coefficients of simple geometries, and that 3D multiphase RANS CFD will be required to generate reliable predictions of platform loads and motions.

  9. Definition extraction for glossary creation : a study on extracting definitions for semi-automatic glossary creation in Dutch

    NARCIS (Netherlands)

    Westerhout, E.N.

    2010-01-01

    The central topic of this thesis is the automatic extraction of definitions from text. Definition extraction can play a role in various applications including the semi-automatic development of glossaries in an eLearning context, which constitutes the main focus of this dissertation. A glossary provi

  10. Nano Petri dishes: a new polystyrene platform for studying cell-nanoengineered surface interactions

    Science.gov (United States)

    Cha, Kyoung Je; Na, Moon-Hee; Kim, Hyung Woo; Kim, Dong Sung

    2014-05-01

    In this study, we fabricated and fully characterized a new type of polystyrene (PS) cell-culture platform containing nanoengineered surfaces (NES), referred to as a nano Petri dish, which can be used at the transition stage of basic cell-NES interaction studies for clinical applications. Nano-injection molding in this study was used for the mass production of the nano Petri dish having nanopore arrays. The effects of processing parameters of the injection molding on the replication quality of the nanopore arrays were quantitatively evaluated by means of design of experiments based on the Taguchi method. This allowed efficient and reliable cell culture studies by providing large numbers of the same dishes, in addition to removing the fixation step of the NES plates inside the cell-culture container. Physical, chemical and mechanical properties of the NES, as well as cell behavior including attachment and proliferation of human osteosarcoma MG-63 cells on the NES, were then characterized, with and without the oxygen plasma surface treatment.

  11. Integration of biostatistics and pharmacometrics computing platforms for efficient and reproducible PK/PD analysis: a case study.

    Science.gov (United States)

    Ou, Ying C; Lo, Arthur; Lee, Brian; Liu, Phillip; Kimura, Karen; Eary, Charisse; Hopkins, Alan

    2013-11-01

    Results of pharmacometric analyses influence high-level decisions such as clinical trial design, drug approval, and labeling. Key challenges for timely delivery of pharmacometric analyses are the data assembly process and tracking and documenting the modeling process and results. Since clinical efficacy and safety data typically reside in the biostatistics computing area, an integrated computing platform for pharmacometric and biostatistical analyses would be ideal. A case study is presented integrating a pharmacometric modeling platform into an existing statistical computing environment (SCE). The feasibility and specific configurations of running common PK/PD programs such as NONMEM and R inside of the SCE are provided. The case study provides an example of an integrated repository that facilitates efficient data assembly for pharmacometrics analyses. The proposed platform encourages a good pharmacometrics working practice to maintain transparency, traceability, and reproducibility of PK/PD models and associated data in supporting drug development and regulatory decisions.

  12. Payment Platform

    DEFF Research Database (Denmark)

    Hjelholt, Morten; Damsgaard, Jan

    2012-01-01

    Payment transactions through the use of physical coins, bank notes or credit cards have for centuries been the standard formats of exchanging money. Recently online and mobile digital payment platforms has entered the stage as contenders to this position and possibly could penetrate societies...... thoroughly and substitute current payment standards in the decades to come. This paper portrays how digital payment platforms evolve in socio-technical niches and how various technological platforms aim for institutional attention in their attempt to challenge earlier platforms and standards. The paper...... applies a co-evolutionary multilevel perspective to model the interplay and processes between technology and society wherein digital payment platforms potentially will substitute other payment platforms just like the credit card negated the check. On this basis this paper formulate a multilevel conceptual...

  13. X-Band Radar for Studies of Tropical Storms from High Altitude UAV Platform

    Science.gov (United States)

    Rodriquez, Shannon; Heymsfield, Gerald; Li, Lihua; Bradley, Damon

    2007-01-01

    The increased role of unmanned aerial vehicles (UAV) in NASA's suborbital program has created a strong interest in the development of instruments with new capabilities, more compact sizes and reduced weights than the instruments currently operated on manned aircrafts. There is a strong demand and tremendous potential for using high altitude UAV (HUAV) to carry weather radars for measurements of reflectivity and wind fields from tropical storms. Tropical storm genesis frequently occurs in ocean regions that are inaccessible to piloted aircraft due to the long off shore range and the required periods of time to gather significant data. Important factors of interest for the study of hurricane genesis include surface winds, profiled winds, sea surface temperatures, precipitation, and boundary layer conditions. Current satellite precipitation and surface wind sensors have resolutions that are too large and revisit times that are too infrequent to study this problem. Furthermore, none of the spaceborne sensors measure winds within the storm itself. A dual beam X-band Doppler radar, UAV Radar (URAD), is under development at the NASA Goddard Space Flight Center for the study of tropical storms from HUAV platforms, such as a Global Hawk. X-band is the most desirable frequency for airborne weather radars since these can be built in a relatively compact size using off-the-shelf components which cost significantly less than other higher frequency radars. Furthermore, X-band radars provide good sensitivity with tolerable attenuation in storms. The low-cost and light-weight URAD will provide new capabilities for studying hurricane genesis by analyzing the vertical structure of tropical cyclones as well as 3D reflectivity and wind fields in clouds. It will enable us to measure both the 3D precipitation structure and surface winds by using two antenna beams: fixed nadir and conical scanning each produced by its associated subsystem. The nadir subsystem is a magnetron based radar

  14. Open soundcard as a platform for practical, laboratory study of digital audio

    DEFF Research Database (Denmark)

    Dimitrov, Smilen; Serafin, Stefania

    2014-01-01

    This article investigates how lacking suitable platforms for laboratory exercises becomes a learning problem, limiting the practical experience students gain. In engineering education, laboratory demonstration difficulty of issues like real-time streaming in digital signal and audio processing is...

  15. A multi-sensor autonomous platform for fast ocean observation studies

    Digital Repository Service at National Institute of Oceanography (India)

    Afzulpurkar, S.; Navelkar, G.S.; Desa, E.; Madhan, R.; Dabholkar, N.A; Prabhudesai, S.P.; Mascarenhas, A.A; Maurya, P.

    A new platform Autonomous Vertical Profiler (AVP) has been developed at CSIR - National Institute of Oceanography in Goa, India that can rapidly and autonomously collect repetitive data to 200m water depth. It is equipped with sensors to measure...

  16. Open soundcard as a platform for practical, laboratory study of digital audio

    DEFF Research Database (Denmark)

    Dimitrov, Smilen; Serafin, Stefania

    2014-01-01

    This article investigates how lacking suitable platforms for laboratory exercises becomes a learning problem, limiting the practical experience students gain. In engineering education, laboratory demonstration difficulty of issues like real-time streaming in digital signal and audio processing...

  17. Functionalized polystyrene nanoparticles as a platform for studying bio–nano interactions

    Science.gov (United States)

    Loos, Cornelia; Syrovets, Tatiana; Musyanovych, Anna; Mailänder, Volker; Landfester, Katharina; Nienhaus, G Ulrich

    2014-01-01

    Summary Nanoparticles of various shapes, sizes, and materials carrying different surface modifications have numerous technological and biomedical applications. Yet, the mechanisms by which nanoparticles interact with biological structures as well as their biological impact and hazards remain poorly investigated. Due to their large surface to volume ratio, nanoparticles usually exhibit properties that differ from those of bulk materials. Particularly, the surface chemistry of the nanoparticles is crucial for their durability and solubility in biological media as well as for their biocompatibility and biodistribution. Polystyrene does not degrade in the cellular environment and exhibits no short-term cytotoxicity. Because polystyrene nanoparticles can be easily synthesized in a wide range of sizes with distinct surface functionalizations, they are perfectly suited as model particles to study the effects of the particle surface characteristics on various biological parameters. Therefore, we have exploited polystyrene nanoparticles as a convenient platform to study bio–nano interactions. This review summarizes studies on positively and negatively charged polystyrene nanoparticles and compares them with clinically used superparamagnetic iron oxide nanoparticles. PMID:25671136

  18. Study on Information Exchange Platform for Port Logistics Based on Web Services

    Institute of Scientific and Technical Information of China (English)

    ZHANG Chanjun; YANG Mingzhong; GUO Shunsheng

    2006-01-01

    Information exchange platform (IEP) for port logistics is used to realize data transmission among different systems and districts by Internet. This paper presents the web services technology used in transferring information for port logistics. The system architecture based on J2EE and B/S mode frame has been constructed to subscribe the distributed information. To ensure platform independent, extensible markup language (XML) integration technology was also used in the system design.

  19. Consumers Intention to Use a Single Platform E-Payment System: A Study Among Malaysian Internet and Mobile Banking Users

    Directory of Open Access Journals (Sweden)

    LAI POEY CHIN

    2015-04-01

    Full Text Available This study seeks to explore Malaysian Internet and Mobile banking consumers’ in adopting a single platform E-payment system using TAM model. This research seeks to investigate whether convenience and design influence perceived ease of use and perceived usefulness. We also investigated the relationship between perceived ease of use, perceived usefulness and perceived risk with consumers’ intention to use one single platform that integrates card, internet and mobile. Respondents who used both the Internet and Mobile banking were selected to participate in the survey. AMOS version 22.0 was used to analyze the data. The empirical results suggest that convenience, design, perceived risk, perceived usefulness and perceived ease of use influence consumers’ intention to use single platform E-payment system. Therefore, convenience, design, perceived risk, perceived usefulness and perceived ease of use should be taken into consideration when designing E-payment system in order to increase the Internet and Mobile banking consumers’ intention to use.

  20. Service Quality of Online Shopping Platforms: A Case-Based Empirical and Analytical Study

    Directory of Open Access Journals (Sweden)

    Tsan-Ming Choi

    2013-01-01

    Full Text Available Customer service is crucially important for online shopping platforms (OSPs such as eBay and Taobao. Based on the well-established service quality instruments and the scenario of the specific case on Taobao, this paper focuses on exploring the service quality of an OSP with an aim of revealing customer perceptions of the service quality associated with the provided functions and investigating their impacts on customer loyalty. By an empirical study, this paper finds that the “fulfillment and responsiveness” function is significantly related to the customer loyalty. Further analytical study is conducted to reveal that the optimal service level on the “fulfillment and responsiveness” function for the risk averse OSP uniquely exists. Moreover, the analytical results prove that (i if the customer loyalty is more positively correlated to the service level, it will lead to a larger optimal service level, and (ii the optimal service level is independent of the profit target, the source of uncertainty, and the risk preference of the OSP.

  1. Platform for the analysis of written texts in terms of conceptual graphs: study case, Cybernetics of Cybernetics course

    Directory of Open Access Journals (Sweden)

    Sebastián Contreras

    2009-02-01

    Full Text Available The objective of this work is to observe and analyze the conceptual-relation structures in texts written in Spanish, from the perspective of second-order cybernetics. Texts are shaped by the syntactic structure of the sentences they contain. Conceptual-relationships emerge by transforming the text, using a text analysis platform named PAST. The transformation is guided by a set of established rules, permitting to observe a system. PAST can be defined as a powerful operator to transform texts written by the students in a Master's Program class. The platform is introduced as a tool enabling a graph representation of relationships among the concepts in the text. The internal procedure of the platform and the graph construction concerns the linguistic analysis. Although the resulting graphic representation does not follow a formal definition, it reflects an iterative construction to define a topology to create a semantic network. This network only makes sense to the author of the text. In other words, the author (observer, based on the cybernetics of the observing systems, uses a tool that enables him to make a second-order observation of a document that he/she has linearly written. The main epistemological concepts mentioned throughout the development of the proposal are discourse and distinction. The contribution of this work is the application of a methodology that conducts a recursive observation of both the direct and indirect relationships established by the words the author puts together in his/her written discourse. In the discussion of results the next phases of this work are presented.

  2. Evaluating the Economic Impact of Smart Care Platforms: Qualitative and Quantitative Results of a Case Study.

    Science.gov (United States)

    Vannieuwenborg, Frederic; Van der Auwermeulen, Thomas; Van Ooteghem, Jan; Jacobs, An; Verbrugge, Sofie; Colle, Didier

    2016-10-31

    In response to the increasing pressure of the societal challenge because of a graying society, a gulf of new Information and Communication Technology (ICT) supported care services (eCare) can now be noticed. Their common goal is to increase the quality of care while decreasing its costs. Smart Care Platforms (SCPs), installed in the homes of care-dependent people, foster the interoperability of these services and offer a set of eCare services that are complementary on one platform. These eCare services could not only result in more quality care for care receivers, but they also offer opportunities to care providers to optimize their processes. The objective of the study was to identify and describe the expected added values and impacts of integrating SCPs in current home care delivery processes for all actors. In addition, the potential economic impact of SCP deployment is quantified from the perspective of home care organizations. Semistructured and informal interviews and focus groups and cocreation workshops with service providers, managers of home care organizations, and formal and informal care providers led to the identification of added values of SCP integration. In a second step, process breakdown analyses of home care provisioning allowed defining the operational impact for home care organization. Impacts on 2 different process steps of providing home care were quantified. After modeling the investment, an economic evaluation compared the business as usual (BAU) scenario versus the integrated SCP scenario. The added value of SCP integration for all actors involved in home care was identified. Most impacts were qualitative such as increase in peace of mind, better quality of care, strengthened involvement in care provisioning, and more transparent care communication. For home care organizations, integrating SCPs could lead to a decrease of 38% of the current annual expenses for two administrative process steps namely, care rescheduling and the billing for

  3. Student Involvement as a Vehicle for Empowerment: A Case Study of the Student Platform for Engineering Education Development

    Science.gov (United States)

    Delaine, David A.; Seif-Naraghi, Sonya B.; Al-Haque, Shahed; Wojewoda, Nicolo; Meninato, Yvonne; DeBoer, Jennifer

    2010-01-01

    This paper examines the mission, structure and outputs of one organisation, the Student Platform for Engineering Education Development (SPEED), as a case study for how student-led organisations can use student involvement to promote and sustain student self-efficacy in an academic field. SPEED attracts young people to engineering through student…

  4. Usability Testing and Expert Inspections Complemented by Educational Evaluation: A Case Study of an e-Learning Platform

    Science.gov (United States)

    Granic, Andrina; Cukusic, Maja

    2011-01-01

    This paper presents a comprehensive usability study conducted within the context of a Europe-wide project. The design of the evaluated e-learning platform is based on an innovative approach to the education of young Europeans by integrating into the curricula of a Europe-wide network of 14 schools different state-of-the-art technologies in…

  5. Development of an inertial confinement fusion platform to study charged-particle-producing nuclear reactions relevant to nuclear astrophysics

    Science.gov (United States)

    Gatu Johnson, M.; Zylstra, A. B.; Bacher, A.; Brune, C. R.; Casey, D. T.; Forrest, C.; Herrmann, H. W.; Hohenberger, M.; Sayre, D. B.; Bionta, R. M.; Bourgade, J.-L.; Caggiano, J. A.; Cerjan, C.; Craxton, R. S.; Dearborn, D.; Farrell, M.; Frenje, J. A.; Garcia, E. M.; Glebov, V. Yu.; Hale, G.; Hartouni, E. P.; Hatarik, R.; Hohensee, M.; Holunga, D. M.; Hoppe, M.; Janezic, R.; Khan, S. F.; Kilkenny, J. D.; Kim, Y. H.; Knauer, J. P.; Kohut, T. R.; Lahmann, B.; Landoas, O.; Li, C. K.; Marshall, F. J.; Masse, L.; McEvoy, A.; McKenty, P.; McNabb, D. P.; Nikroo, A.; Parham, T. G.; Paris, M.; Petrasso, R. D.; Pino, J.; Radha, P. B.; Remington, B.; Rinderknecht, H. G.; Robey, H.; Rosenberg, M. J.; Rosse, B.; Rubery, M.; Sangster, T. C.; Sanchez, J.; Schmitt, M.; Schoff, M.; Séguin, F. H.; Seka, W.; Sio, H.; Stoeckl, C.; Tipton, R. E.

    2017-04-01

    This paper describes the development of a platform to study astrophysically relevant nuclear reactions using inertial-confinement fusion implosions on the OMEGA and National Ignition Facility laser facilities, with a particular focus on optimizing the implosions to study charged-particle-producing reactions. Primary requirements on the platform are high yield, for high statistics in the fusion product measurements, combined with low areal density, to allow the charged fusion products to escape. This is optimally achieved with direct-drive exploding pusher implosions using thin-glass-shell capsules. Mitigation strategies to eliminate a possible target sheath potential which would accelerate the emitted ions are discussed. The potential impact of kinetic effects on the implosions is also considered. The platform is initially employed to study the complementary T(t,2n)α, T(3He,np)α and 3He(3He,2p)α reactions. Proof-of-principle results from the first experiments demonstrating the ability to accurately measure the energy and yields of charged particles are presented. Lessons learned from these experiments will be used in studies of other reactions. The goals are to explore thermonuclear reaction rates and fundamental nuclear physics in stellar-like plasma environments, and to push this new frontier of nuclear astrophysics into unique regimes not reachable through existing platforms, with thermal ion velocity distributions, plasma screening, and low reactant energies.

  6. Synthetic strategies for plant signalling studies: molecular toolbox and orthogonal platforms

    KAUST Repository

    Braguy, Justine

    2016-05-26

    Plants deploy a wide array of signalling networks integrating environmental cues with growth, defence and developmental responses. The high level of complexity, redundancy and connection between several pathways hampers a comprehensive understanding of involved functional and regulatory mechanisms. The implementation of synthetic biology approaches is revolutionizing experimental biology in prokaryotes, yeasts and animal systems and can likewise contribute to a new era in plant biology. This review gives an overview on synthetic biology approaches for the development and implementation of synthetic molecular tools and techniques to interrogate, understand and control signalling events in plants, ranging from strategies for the targeted manipulation of plant genomes up to the spatiotemporally resolved control of gene expression using optogenetic approaches. We also describe strategies based on the partial reconstruction of signalling pathways in orthogonal platforms, like yeast, animal and in vitro systems. This allows a targeted analysis of individual signalling hubs devoid of inter-connectivity with endogenous interacting components. Implementation of the interdisciplinary synthetic biology tools and strategies is not exempt of challenges and hardships but simultaneously most rewarding in terms of the advances in basic and applied research. As witnessed in other areas, these original theoretical-experimental avenues will lead to a breakthrough in the ability to study and comprehend plant signalling networks. This article is protected by copyright. All rights reserved.

  7. The Construction and Study of Nansi Lake Water Environment Management Platform Based on WebGIS

    Institute of Scientific and Technical Information of China (English)

    XU; Qiu-xiao

    2012-01-01

    According to targets and needs of Nansi Lake water eco-environment management, we took the advantages that WebGIS serves as an overall solution, combined characteristic of SuperMap IS.net WebGIS service platform and adopted the B/S three-tier distributed architecture to put forward the overall design idea, function structure and structure scheme of Nansihu water eco-environment assessment and management WebGIS. Subsequently, we used the C# programming language to carry out the concrete development job, and figured out a scheme to store and disseminate space data and attributes data. Ultimately, with the aid of SuperMap's large-scale spatial database engine SDX+, the system has realized a lot of functions such as spatial information search, hydrology and water quality information inquiry and statistics, water environment quality assessment, lake eutrophication assessment, embodying the visualization of systems analysis sufficiently. The system has been mainly studied and developed in the technology of lake eco-environment management, and also provided an intuitionistic, universal, convenient and reliable management tool for Nansihu water eco-environment management.

  8. KITcube – a mobile observation platform for convection studies deployed during HyMeX

    Directory of Open Access Journals (Sweden)

    Norbert Kalthoff

    2013-12-01

    Full Text Available With the increase of spatial resolution of weather forecast models to order O(1 km, the need for adequate observations for model validation becomes evident. Therefore, we designed and constructed the "KITcube", a mobile observation platform for convection studies of processes on the meso-? scale. The KITcube consists of in-situ and remote sensing systems which allow measuring the energy balance components of the Earth's surface at different sites; the mean atmospheric conditions by radiosondes, GPS station, and a microwave radiometer; the turbulent characteristics by a sodar and wind lidars; and cloud and precipitation properties by use of a cloud radar, a micro rain radar, disdrometers, rain gauges, and an X-band rain radar. The KITcube was deployed fully for the first time on the French island of Corsica during the HyMeX (Hydrological cycle in the Mediterranean eXperiment field campaign in 2012. In this article, the components of KITcube and its implementation on the island are described. Moreover, results from one of the HyMeX intensive observation periods are presented to show the capabilities of KITcube.

  9. Integrated cell-based platform to study EGFR activation and transactivation.

    Science.gov (United States)

    Caruso, Marie-Elaine; Clément, Paule; Parent, Stéphane; Dupriez, Vincent; Bossé, Roger; Rouleau, Nathalie

    2013-09-01

    The epidermal growth factor receptor (EGFR) pathway is one of the most deregulated molecular pathways in human epithelial cancers. Many approved drugs were optimized to directly target EGFR but yielded only modest clinical improvement in cancer patients due to low efficacy and drug resistance. Transactivation of EGFR by other cell surface receptors such as G-protein-coupled receptors (GPCRs) was proposed to explain this lack of efficacy. Even if direct EGFR activation and transactivation by GPCR contribute to the activation of the same signaling pathways, they are often studied as independent events resulting in partial investigation of a drug's mechanism of action. We present a novel high-throughput approach that integrates interrogation of direct activation of EGFR and its transactivation via GPCR activation. Using distinct technology platforms, three readouts were used to measure (1) direct activation of GPCR via cyclic adenosine monophosphate (cAMP) detection, (2) direct activation of EGFR through the release of intracellular Ca(2+), and (3) EGFR transactivation by GPCR using the detection of p-extracellular-signal-regulated kinases 1/2 (p-ERK1/2). In addition to being simple, quick, and homogenous, our methods were shown to be more sensitive than those in current use. These enabling tools should improve the knowledge pertaining to GPCRs and receptor tyrosine kinases trans-regulation and facilitate the design of more potent and better targeted new therapeutic strategies.

  10. The Construction and Study of Nansi Lake Water Environment Management Platform Based on WebGIS

    Institute of Scientific and Technical Information of China (English)

    XU; Qiu-xiao

    2012-01-01

    According to targets and needs of Nansi Lake water eco-environment management, we took the advantages that WebGIS serves as an overall solution, combined characteristic of SuperMap IS.net WebGIS service platform and adopted the B/S three-tier distributed architecture to put forward the overall design idea, function structure and structure scheme of Nansihu water eco-environment assessment and management WebGIS. Subsequently, we used the C# programming language to carry out the concrete development job, and figured out a scheme to store and disseminate space data and attributes data. Ultimately, with the aid of SuperMap’s large-scale spatial database engine SDX+, the system has realized a lot of functions such as spatial information search, hydrology and water quality information inquiry and statistics, water environment quality assessment, lake eutrophication assessment, embodying the visualization of systems analysis sufficiently. The system has been mainly studied and developed in the technology of lake eco-environment management, and also provided an intuitionistic, universal, convenient and reliable management tool for Nansihu water eco-environment management.

  11. Safety impacts of platform tram stops on pedestrians in mixed traffic operation: A comparison group before-after crash study.

    Science.gov (United States)

    Naznin, Farhana; Currie, Graham; Logan, David; Sarvi, Majid

    2016-01-01

    Tram stops in mixed traffic environments present a variety of safety, accessibility and transport efficiency challenges. In Melbourne, Australia the hundred year-old electric tram system is progressively being modernized to improve passenger accessibility. Platform stops, incorporating raised platforms for level entry into low floor trams, are being retro-fitted system-wide to replace older design stops. The aim of this study was to investigate the safety impacts of platform stops over older design stops (i.e. Melbourne safety zone tram stops) on pedestrians in the context of mixed traffic tram operation in Melbourne, using an advanced before-after crash analysis approach, the comparison group (CG) method. The CG method evaluates safety impacts by taking into account the general trends in safety and the unobserved factors at treatment and comparison sites that can alter the outcomes of a simple before-after analysis. The results showed that pedestrian-involved all injury crashes reduced by 43% after platform stop installation. This paper also explores a concern that the conventional CG method might underestimate safety impacts as a result of large differences in passenger stop use between treatment and comparison sites, suggesting differences in crash risk exposure. To adjust for this, a modified analysis explored crash rates (crash counts per 10,000 stop passengers) for each site. The adjusted results suggested greater reductions in pedestrian-involved crashes after platform stop installation: an 81% reduction in pedestrian-involved all injury crashes and 86% reduction in pedestrian-involved FSI crashes, both are significant at the 95% level. Overall, the results suggest that platform stops have considerable safety benefits for pedestrians. Implications for policy and areas for future research are explored.

  12. An open-source platform to study uniaxial stress effects on nanoscale devices

    Science.gov (United States)

    Signorello, G.; Schraff, M.; Zellekens, P.; Drechsler, U.; Bürge, M.; Steinauer, H. R.; Heller, R.; Tschudy, M.; Riel, H.

    2017-05-01

    We present an automatic measurement platform that enables the characterization of nanodevices by electrical transport and optical spectroscopy as a function of the uniaxial stress. We provide insights into and detailed descriptions of the mechanical device, the substrate design and fabrication, and the instrument control software, which is provided under open-source license. The capability of the platform is demonstrated by characterizing the piezo-resistance of an InAs nanowire device using a combination of electrical transport and Raman spectroscopy. The advantages of this measurement platform are highlighted by comparison with state-of-the-art piezo-resistance measurements in InAs nanowires. We envision that the systematic application of this methodology will provide new insights into the physics of nanoscale devices and novel materials for electronics, and thus contribute to the assessment of the potential of strain as a technology booster for nanoscale electronics.

  13. Credit Risk Analysis of Local Government Financing Platform – An empirical study based on KMV model

    Directory of Open Access Journals (Sweden)

    Zhou Tingting

    2015-01-01

    Full Text Available The local government financing platform is set up by local government through state-owned assets, real estate and equity capital. The functions of these companies are financing, construction, operation, the repaying debts. The local government financing platform can broaden the financing channels of local government in a great extent; alleviate the pressure of capital requirement. But at the same time, with the gradual expansion of the scale of debt, a series of problems has arisen: the amount of financing platform companies is huge, debt repayment depends too much on real estate price, the integration of government administration with enterprise, capital injection, and accounts of these companies are not well exposed. Once these problems outbreak, it may cause a series of financial crises, thereby threaten the entire banking industry even the healthy development of the national economy.

  14. Floated pallet definition study. Volume 4: Summary volume

    Science.gov (United States)

    1975-01-01

    The conceptual design of a suspension system for the Floated Pallet and a retention system to support the pallet during launch, maneuvering and descent are described. In addition, a control moment gyroscope support equipment configuration study including installation and an experiment mount and erection study was performed. The impact of these separate hardware studies on the existing pallet configuration was assessed and a modified pallet common module defined.

  15. A simple microfluidic platform to study age-dependent protein abundance and localization changes in Saccharomyces cerevisiae

    Directory of Open Access Journals (Sweden)

    Margarita Cabrera

    2017-04-01

    Full Text Available The budding yeast Saccharomyces cerevisiae divides asymmetrically, with a smaller daughter cell emerging from its larger mother cell. While the daughter lineage is immortal, mother cells age with each cell division and have a finite lifespan. The replicative ageing of the yeast mother cell has been used as a model to study the ageing of mitotically active human cells. Several microfluidic platforms, which use fluid flow to selectively remove daughter cells, have recently been developed that can monitor cell physiology as mother cells age. However, these platforms are not trivial to set up and users often require many hours of training. In this study, we have developed a simple system, which combines a commercially available microfluidic platform (the CellASIC ONIX Microfluidic Platform and a genetic tool to prevent the proliferation of daughter cells (the Mother Enrichment Program, to monitor protein abundance and localization changes during approximately the first half of the yeast replicative lifespan. We validated our system by observing known age-dependent changes, such as decreased Sir2 abundance, and have identified a protein with a previously unknown age-dependent change in localization.

  16. Flight Simulator Platform Motion and Air Transport Pilot Training

    Science.gov (United States)

    Lee, Alfred T.; Bussolari, Steven R.

    1989-01-01

    The influence of flight simulator platform motion on pilot training and performance was examined In two studies utilizing a B-727-200 aircraft simulator. The simulator, located at Ames Research Center, Is certified by the FAA for upgrade and transition training in air carrier operations. Subjective ratings and objective performance of experienced B-727 pilots did not reveal any reliable effects of wide variations In platform motion de- sign. Motion platform variations did, however, affect the acquisition of control skill by pilots with no prior heavy aircraft flying experience. The effect was limited to pitch attitude control inputs during the early phase of landing training. Implications for the definition of platform motion requirements in air transport pilot training are discussed.

  17. Theoretical and Experimental Studies of Wave Impact underneath Decks of Offshore Platforms

    Energy Technology Data Exchange (ETDEWEB)

    Baarholm, Rolf Jarle

    2001-07-01

    The main objective of this thesis has been to study the phenomenon of water impact underneath the decks of offshore platforms due to propagating waves. The emphasis has been on the impact loads. Two theoretical methods based on two-dimensional potential theory have been developed, a Wagner based method (WBM) and a nonlinear boundary element method (BEM). A procedure to account for three-dimensional effects is suggested. The deck is assumed to be rigid. Initial studies of the importance of hydroelasticity for wave loads on an existing deck structure have been performed. For a given design wave, the local structural responses were found to behave quasi-static. Global structural response has not been studied. In the Wagner based method gravity is neglected and a linear spatial distribution of the relative impact velocity along the deck is assumed. The resulting boundary value problem is solved analytically for each time step. A numerical scheme for stepping the wetted deck area in time is presented. The nonlinear boundary element method includes gravity, and the exact impact velocity is considered. The incident wave velocity potential is given a priori, and a boundary value problem for the perturbation velocity potential associated with the impact is defined. The boundary value problem is solved for each time step by applying Green's second identity. The exact boundary conditions are imposed on the exact boundaries. A Kutta condition is introduced as the fluid flow reaches the downstream end of the deck. At present, the BEM is only applicable for fixed platform decks. To validate the theories, experiments have been carried out in a wave flume. The experiments were performed in two-dimensional flow condition with a fixed horizontal deck at different vertical levels above the mean free surface. The vertical force on the deck and the wetting of the deck were the primary parameters measured. Only regular propagating waves were applied. When a wave hits the deck, the

  18. Presidential Rhetoric: Definition of a Field of Study.

    Science.gov (United States)

    Windt, Theodore Otto, Jr.

    1984-01-01

    Surveys literature published since 1960, dividing it into four categories of critical analyses. Evaluates current knowledge of presidential rhetoric and suggests directions for future research in this field of study. (PD)

  19. A preliminary study on the definitions and differences of main types of business arrangements

    Directory of Open Access Journals (Sweden)

    Anderson Tiago Peixoto Gonçalves

    2012-08-01

    Full Text Available With the growth of competitiveness and market requirements, several companies have been jointly organized with the aim of forming partnerships, forming the so-called Business Arrangements, to ensure that competitive advantages are achieved. This article came from the need to review the definitions and differences between the main types of existing Business Arrangements, as in the literature have been used different nomenclatures and classifications, either in terms of how the Arrangement is managed, how it is organized, the according to which members carry out their activities, how is the flow of resources and information, the degree of coordination and interaction, the form of production organization, and the strategies adopted. It is a basic research, descriptive and literature, which sought to collect the relevant sources, definitions about each Arrangement to meet the goal of the article is to study the definitions and differences between the main types of Business Arrangements. The article is justified by the scarcity of uniform definitions in the literature that make it possible to visualize the differences between each of the types of Arrangements, especially those in which the definitions are more similar.

  20. Definitions of medication-overuse headache in population-based studies and their implications on prevalence estimates

    DEFF Research Database (Denmark)

    Westergaard, Maria L.; Hansen, Ebba Holme; Glümer, Charlotte

    2014-01-01

    Case definitions of medication-overuse headache (MOH) in population-based research have changed over time. This study aims to review MOH prevalence reports with respect to these changes, and to propose a practical case definition for future studies based on the ICHD-3 beta.......Case definitions of medication-overuse headache (MOH) in population-based research have changed over time. This study aims to review MOH prevalence reports with respect to these changes, and to propose a practical case definition for future studies based on the ICHD-3 beta....

  1. Objectives and Model Payload Definition for NEO Human Mission Studies

    Science.gov (United States)

    Carnelli, I.; Galvez, A.; Carpenter, J.

    2011-10-01

    ESA has supported studies on NEO threat assessment systems and deflection concepts in the context of the General Studies Programme and in close cooperation with the directorates of Technical and Quality Management and of the Scientific Programme. This work has made it possible to identify a project for Europe to make a significant - yet realistic - contribution to the international efforts in this field: the Don Quijote NEO technology demonstration mission. This paper describes what such a small mission can do to prepare future human exploration and what is the in-situ data that can be obtained through such a project.

  2. Combined Cell Culture-Biosensing Platform Using Vertically Aligned Patterned Peptide Nanofibers for Cellular Studies

    DEFF Research Database (Denmark)

    Taskin, Mehmet B.; Sasso, Luigi; Dimaki, Maria

    2013-01-01

    This Article presents the development of a combined cell culture–biosensing platform using vertically aligned self-assembled peptide nanofibers. Peptide nanofibers were patterned on a microchip containing gold microelectrodes to provide the cells with a 3D environment enabling them to grow and pr...

  3. Competing definitions of schizophrenia: what can be learned from polydiagnostic studies?

    DEFF Research Database (Denmark)

    Jansson, Lennart B; Parnas, Josef

    2007-01-01

    The contemporary diagnoses of schizophrenia (sz)-Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition(DSM-IV) and International Classification of Diseases, 10th Revision(ICD-10)-are widely considered as important scientific achievements. However, these algorithms were not a product...... of explicit conceptual analyses and empirical studies but defined through consensus with the purpose of improving reliability. The validity status of current definitions and of their predecessors remains unclear. The so-called "polydiagnostic approach" applies different definitions of a disorder to the same...

  4. Development and Validation of an Interactive Internet Platform for Older People: The Healthy Ageing Through Internet Counselling in the Elderly Study.

    Science.gov (United States)

    Jongstra, Susan; Beishuizen, Cathrien; Andrieu, Sandrine; Barbera, Mariagnese; van Dorp, Matthijs; van de Groep, Bram; Guillemont, Juliette; Mangialasche, Francesca; van Middelaar, Tessa; Moll van Charante, Eric; Soininen, Hilkka; Kivipelto, Miia; Richard, Edo

    2017-02-01

    A myriad of Web-based applications on self-management have been developed, but few focus on older people. In the face of global aging, older people form an important target population for cardiovascular prevention. This article describes the full development of an interactive Internet platform for older people, which was designed for the Healthy Ageing Through Internet Counselling in the Elderly (HATICE) study. We provide recommendations to design senior-friendly Web-based applications for a new approach to multicomponent cardiovascular prevention. The development of the platform followed five phases: (1) conceptual framework; (2) platform concept and functional design; (3) platform building (software and content); (4) testing and pilot study; and (5) final product. We performed a meta-analysis, reviewed guidelines for cardiovascular diseases, and consulted end users, experts, and software developers to create the platform concept and content. The software was built in iterative cycles. In the pilot study, 41 people aged ≥65 years used the platform for 8 weeks. Participants used the interactive features of the platform and appreciated the coach support. During all phases adjustments were made to incorporate all improvements from the previous phases. The final platform is a personal, secured, and interactive platform supported by a coach. When carefully designed, an interactive Internet platform is acceptable and feasible for use by older people with basic computer skills. To improve acceptability by older people, we recommend involving the end users in the process of development, to personalize the platform and to combine the application with human support. The interactive HATICE platform will be tested for efficacy in a multinational randomized controlled trial (ISRCTN48151589).

  5. 企业云开发平台研究%Study on Enterprise Cloud Development Platform

    Institute of Scientific and Technical Information of China (English)

    邓超; 周文平; 申新鹏; 杨刚

    2012-01-01

    企业云开发平台提供了一个虚拟的开发环境,开发者可以很方便的获得开发和测试环境.使得开发者可以将精力集中于应用的开发,提供更好的产品.同时该平台还提供了云体验功能,使用户可以在云端试用产品,发现问题,减少购买的盲目性.开发者在云端模拟用户的环境,再现用户的问题,迅速找到解决方案.平台的提供商使用这个平台可以有效地宣传自己的产品,增加合作伙伴和用户的数量.企业云开发平台建立了一个多赢的生态链.%Enterprise cloud development platform provides a virtual development environment.Using it,the developers can easily build the development and test environment.So the developers can focus on application development to provide better products.The platform also provides a cloud experience service.Based on the service,users can try the product in the clouds.Before they bought the software product,they could identify problems,reduce the purchase of blindness.The developers could simulation user environment in the clouds.It could help them to reproduce the users' problem and quickly find a solution.Platform provider can use this platform to effectively promote their products,increase the number of partners and users.This platform can form a win-win ecosystem.

  6. [Lens platform].

    Science.gov (United States)

    Łukaszewska-Smyk, Agnieszka; Kałuzny, Józef

    2010-01-01

    The lens platform defines lens structure and lens material. Evolution of lens comprises change in their shape, angulation of haptens and transition of three-piece lens into one-piece lens. The lens fall into two categories: rigid (PMMA) and soft (siliconic, acrylic, colameric). The main lens maaterials are polymers (hydrophilic and hydrophobic). The lens platform has an effect on biocompatibility, bioadhesion, stability of lens in capsule, degree of PCO evolution and sensitiveness to laser damages.

  7. Platform contents

    OpenAIRE

    Renault, Régis

    2014-01-01

    A monopoly platform hosts advertisers who compete on a market for horizontally differentiated products. These products may be either mass market products that appeal broadly to the entire consumer population or niche products that are tailored to the tastes of some particular group. Consumers search sequentially through ads incurring a surfing cost of moving to the next ad. They may click on an ad at some cost, which provides all relevant information and the opportunity to buy. The platform c...

  8. An Exploratory Study of a Robotics Educational Platform on STEM Career Interests in Middle School Students

    Science.gov (United States)

    Hinton, Tracy Barger

    With the large expected growth in STEM-related careers in American industries, there are not enough graduates to fill these positions (United States Department of Labor, 2015). Increased efforts are being made to reform STEM education from early childhood to college level studies, mainly through increased efforts to incorporate new technologies and project-based learning activities (Hegedorn & Purnamasari, 2012). At the middle school level, a robotics educational platform can be a worthwhile activity that provides hands-on learning as students learn basic programming and engineering skills (Grubbs, 2013). Based on the popularity of LEGO toys, LEGO Education developed an engaging and effective way to learn about computer programming and basic engineering concepts (Welch & Huffman, 2011). LEGO MINDSTORMS offers a project-based learning environment that engages students in real-life, problem-solving challenges. The purpose of this qualitative study was to investigate the instructional use of a robotics educational curriculum on middle school students' attitudes toward and interests in STEM and their experiences with LEGO Robotics activities. Participants included 23 seventh grade students who were enrolled in a Career Cluster Technologies I class in a suburban middle school. Data for the study were collected from three focus group interviews, open-ended surveys, classroom observations, and the Career Cruising program. Findings revealed that the robotics activities led to an increased interest and higher self-efficacy in STEM tasks. If students continue to nurture and develop their STEM interests, it is possible that many of them may develop higher confidence and eventually set personal goals related to STEM classes and careers. While other studies have been conducted on similar topics, this qualitative research is unique because it contributed to the gap in research that investigates the impact of an in-class robotics curriculum on middle school students' attitudes

  9. Preliminary Problem Definition Study on Munitions-Related Chemicals.

    Science.gov (United States)

    1979-04-01

    literature; how- S ever, Sander et al. (1975a, b) studied the effect of N-nitrosomorpholine in a series of experiments with cress plants (Lepidiwu sativum...Adenomas by Amines or Ureas Plus Nitrite and by N-Nitroso Compounds: Effect of Ascorbate, Gallic Acid, Thiocyanate, and Caffine ," j. Nat’l Cancer instit...Washington, D.C. Garber, K. (1970), "Air Pollution by Heavy-Metal-Containing Dusts. Effects on Plants ." LandAirt, Forsch, Sonderh., 25, 59-68

  10. Definitions and Uses: Case Study of Teachers Implementing Project-Based Learning

    Science.gov (United States)

    Tamim, Suha R.; Grant, Michael M.

    2013-01-01

    The purpose of this descriptive study was to explore inservice teachers' definitions of project-based learning (PjBL) and their accounts on the meaning of their PjBL implementations. A purposive sample of six teachers from grades four through twelve in public and private schools participated. Three themes evolved from inductive analysis: (1)…

  11. Ports: Definition and study of types, sizes and business models

    Directory of Open Access Journals (Sweden)

    Ivan Roa

    2013-09-01

    Full Text Available Purpose: In the world today there are thousands of port facilities of different types and sizes, competing to capture some market share of freight by sea, mainly. This article aims to determine the type of port and the most common size, in order to find out which business model is applied in that segment and what is the legal status of the companies of such infrastructure.Design/methodology/approach: To achieve this goal, we develop a research on a representative sample of 800 ports worldwide, which manage 90% of the containerized port loading. Then you can find out the legal status of the companies that manage them.Findings: The results indicate a port type and a dominant size, which are mostly managed by companies subject to a concession model.Research limitations/implications: In this research, we study only those ports that handle freight (basically containerized, ignoring other activities such as fishing, military, tourism or recreational.Originality/value: This is an investigation to show that the vast majority of the studied segment port facilities are governed by a similar corporate model and subject to pressure from the markets, which increasingly demand efficiency and service. Consequently, we tend to concession terminals to private operators in a process that might be called privatization, but in the strictest sense of the term, is not entirely realistic because the ownership of the land never ceases to be public

  12. Space station resistojet system requirements and interface definition study

    Science.gov (United States)

    Heckert, Bruce J.

    1987-01-01

    Preliminary resistojet design requirements were established based on initial technical requirements imposed by the results of NASA and Rocketdyne studies. The requirements are directed toward long life, simplicity, flexibility, and commonality with other space station components. The resistojet assembly is comprised of eight resistojets, fluid components downstream of the waste fluid storage system, a power controller, structure, and shielding. It consists of two identical subassemblies, one of which is redundant. Each subassembly consists of four 500-W resistojets, series redundant latch values, a power controller, a water vaporizer, two pressure regulators, filters, check valves, disconnects, fluid tubing, and electrical cables. All components are packaged at the end of the stinger aft of the JEM and Columbus modules. Different flow and power control methods were studied. A constant inlet pressure and a two-power setting controller were tentatively selected based on simplicity and reasonably high specific impulse for the range of waste gas compositions that are anticipated. The constant pressure is supplied by pressure regulators. The two set point power control includes individual power supplies to each resistojet heater and water vaporizer. An embedded data processor, a multiplexer-demultiplexer, and a network interface unit that are standard space station components are included in the power controller. The total dry weight of the resistojet assembly is approximately 172 lb. The total cost for design, development, test, evaluation, qualification, and flight hardware is estimated to be $16 million.

  13. A comparative study on the elastic modulus of polyvinyl alcohol sponge using different stress-strain definitions.

    Science.gov (United States)

    Karimi, Alireza; Navidbakhsh, Mahdi; Alizadeh, Mansour; Razaghi, Reza

    2014-10-01

    There have been different stress-strain definitions to measure the elastic modulus of spongy materials, especially polyvinyl alcohol (PVA) sponge. However, there is no agreement as to which stress-strain definition should be implemented. This study was aimed to show how different results are given by the various definitions of stress-strain used, and to recommend a specific definition when testing spongy materials. A fabricated PVA sponge was subjected to a series of tensile tests in order to measure its mechanical properties. Three stress definitions (second Piola-Kichhoff stress, engineering stress, and true stress) and four strain definitions (Almansi-Hamel strain, Green-St. Venant strain, engineering strain, and true strain) were used to determine the elastic modulus. The results revealed that the Almansi-Hamel strain definition exhibited the highest non-linear stress-strain relation and, as a result, may overestimate the elastic modulus at different stress definitions (second Piola-Kichhoff stress, engineering stress, and true stress). The Green-St. Venant strain definition failed to address the non-linear stress-strain relation using different definitions of stress and invoked an underestimation of the elastic modulus values. Engineering stress and strain definitions were only valid for small strains and displacements, which make them impractical when analyzing spongy materials. The results showed that the effect of varying the stress definition on the maximum stress measurements was significant but not when calculating the elastic modulus. It is important to consider which stress-strain definition is employed when characterizing the mechanical properties of spongy materials. Although the true stress-true strain definition exhibits a non-linear relation, we favor it in spongy materials mechanics as it gives more accurate measurements of the material's response using the instantaneous values.

  14. Definition of requirements for geothermal power conversion system studies

    Energy Technology Data Exchange (ETDEWEB)

    1977-06-30

    Candidate power conversion systems and criteria for comparing these systems are listed. The elements of each conceptual design and standard approaches to equipment design are described. The methods used to calculate heat and mass balances and the data used in the calculations are described. The method used in developing the economics of each system is described and factors such as construction wage rates common to all systems are included. Standard methods for developing the conceptual designs and corresponding economics are defined so that the results of each system study can be readily compared to those of the others. The candidate conversion systems are: multistage flash/binary; two stage flash with scrubbing; total flow; multistage flash/direct contact (Bechtel patented process); four stage flash/binary; binary with direct contact heat exchangers; hybrid-flash/binary; hybrid-flash/total flow; and flash/dual cycle binary. (MHR)

  15. Placenta-on-a-chip: a novel platform to study the biology of the human placenta.

    Science.gov (United States)

    Lee, Ji Soo; Romero, Roberto; Han, Yu Mi; Kim, Hee Chan; Kim, Chong Jai; Hong, Joon-Seok; Huh, Dongeun

    2016-01-01

    Studying the biology of the human placenta represents a major experimental challenge. Although conventional cell culture techniques have been used to study different types of placenta-derived cells, current in vitro models have limitations in recapitulating organ-specific structure and key physiological functions of the placenta. Here we demonstrate that it is possible to leverage microfluidic and microfabrication technologies to develop a microengineered biomimetic model that replicates the architecture and function of the placenta. A "Placenta-on-a-Chip" microdevice was created by using a set of soft elastomer-based microfabrication techniques known as soft lithography. This microsystem consisted of two polydimethylsiloxane (PDMS) microfluidic channels separated by a thin extracellular matrix (ECM) membrane. To reproduce the placental barrier in this model, human trophoblasts (JEG-3) and human umbilical vein endothelial cells (HUVECs) were seeded onto the opposite sides of the ECM membrane and cultured under dynamic flow conditions to form confluent epithelial and endothelial layers in close apposition. We tested the physiological function of the microengineered placental barrier by measuring glucose transport across the trophoblast-endothelial interface over time. The permeability of the barrier study was analyzed and compared to that obtained from acellular devices and additional control groups that contained epithelial or endothelial layers alone. Our microfluidic cell culture system provided a tightly controlled fluidic environment conducive to the proliferation and maintenance of JEG-3 trophoblasts and HUVECs on the ECM scaffold. Prolonged culture in this model produced confluent cellular monolayers on the intervening membrane that together formed the placental barrier. This in vivo-like microarchitecture was also critical for creating a physiologically relevant effective barrier to glucose transport. Quantitative investigation of barrier function was

  16. Project definition study for the National Biomedical Tracer Facility

    Energy Technology Data Exchange (ETDEWEB)

    Roozen, K.

    1995-02-15

    The University of Alabama at Birmingham (UAB) has conducted a study of the proposed National Biomedical Tracer Facility (NBTF). In collaboration with General Atomics, RUST International, Coleman Research Corporation (CRC), IsoMed, Ernst and Young and the advisory committees, they have examined the issues relevant to the NBTF in terms of facility design, operating philosophy, and a business plan. They have utilized resources within UAB, CRC and Chem-Nuclear to develop recommendations on environmental, safety and health issues. The Institute of Medicine Panel`s Report on Isotopes for Medicine and the Life Sciences took the results of prior workshops further in developing recommendations for the mission of the NBTF. The IOM panel recommends that the NBTF accelerator have the capacity to accelerate protons to 80 MeV and a minimum of 750 microamperes of current. The panel declined to recommend a cyclotron or a linac. They emphasized a clear focus on research and development for isotope production including target design, separation chemistry and generator development. The facility needs to emphasize education and training in its mission. The facility must focus on radionuclide production for the research and clinical communities. The formation of a public-private partnership resembling the TRIUMF-Nordion model was encouraged. An advisory panel should assist with the NBTF operations and prioritization.

  17. Appropriateness of the definition of 'sedentary' in young children: Whole-room calorimetry study.

    Science.gov (United States)

    Reilly, John J; Janssen, Xanne; Cliff, Dylan P; Okely, Anthony D

    2015-09-01

    The present study aimed to measure the energy cost of three common sedentary activities in young children to test whether energy expended was consistent with the recent consensus definition of 'sedentary' as 'any behaviour conducted in a sitting or reclining posture and with an energy cost ≤ 1.5 metabolic equivalents (METs)' (Sedentary Behaviour Research Network, 2012). Observational study. Whole-room calorimetry measures of television viewing, sitting at a table drawing and reading, and sitting on the floor playing with toys were made in 40 young children (mean age 5.3 years, SD 1.0). The energy cost of each sedentary activity was consistent with the recent consensus definition of sedentary: 1.17 METs (95% CI 1.07-1.27) for TV viewing; 1.38 METs (95% CI 1.30-1.46) for sitting at a table; and 1.35 METs (95% CI 1.28-1.43) for floor-based play. Common sedentary activities in young children have energy costs which are consistent with the recent consensus definition of 'sedentary', and the present study is supportive of this definition. Copyright © 2014 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.

  18. 3D virtual human atria: A computational platform for studying clinical atrial fibrillation.

    Science.gov (United States)

    Aslanidi, Oleg V; Colman, Michael A; Stott, Jonathan; Dobrzynski, Halina; Boyett, Mark R; Holden, Arun V; Zhang, Henggui

    2011-10-01

    Despite a vast amount of experimental and clinical data on the underlying ionic, cellular and tissue substrates, the mechanisms of common atrial arrhythmias (such as atrial fibrillation, AF) arising from the functional interactions at the whole atria level remain unclear. Computational modelling provides a quantitative framework for integrating such multi-scale data and understanding the arrhythmogenic behaviour that emerges from the collective spatio-temporal dynamics in all parts of the heart. In this study, we have developed a multi-scale hierarchy of biophysically detailed computational models for the human atria--the 3D virtual human atria. Primarily, diffusion tensor MRI reconstruction of the tissue geometry and fibre orientation in the human sinoatrial node (SAN) and surrounding atrial muscle was integrated into the 3D model of the whole atria dissected from the Visible Human dataset. The anatomical models were combined with the heterogeneous atrial action potential (AP) models, and used to simulate the AP conduction in the human atria under various conditions: SAN pacemaking and atrial activation in the normal rhythm, break-down of regular AP wave-fronts during rapid atrial pacing, and the genesis of multiple re-entrant wavelets characteristic of AF. Contributions of different properties of the tissue to mechanisms of the normal rhythm and arrhythmogenesis were investigated. Primarily, the simulations showed that tissue heterogeneity caused the break-down of the normal AP wave-fronts at rapid pacing rates, which initiated a pair of re-entrant spiral waves; and tissue anisotropy resulted in a further break-down of the spiral waves into multiple meandering wavelets characteristic of AF. The 3D virtual atria model itself was incorporated into the torso model to simulate the body surface ECG patterns in the normal and arrhythmic conditions. Therefore, a state-of-the-art computational platform has been developed, which can be used for studying multi

  19. Stress analysis in platform-switching implants: a 3-dimensional finite element study.

    Science.gov (United States)

    Pellizzer, Eduardo Piza; Verri, Fellippo Ramos; Falcón-Antenucci, Rosse Mary; Júnior, Joel Ferreira Santiago; de Carvalho, Paulo Sérgio Perri; de Moraes, Sandra Lúcia Dantas; Noritomi, Pedro Yoshito

    2012-10-01

    The aim of this study was to evaluate the influence of the platform-switching technique on stress distribution in implant, abutment, and peri-implant tissues, through a 3-dimensional finite element study. Three 3-dimensional mandibular models were fabricated using the SolidWorks 2006 and InVesalius software. Each model was composed of a bone block with one implant 10 mm long and of different diameters (3.75 and 5.00 mm). The UCLA abutments also ranged in diameter from 5.00 mm to 4.1 mm. After obtaining the geometries, the models were transferred to the software FEMAP 10.0 for pre- and postprocessing of finite elements to generate the mesh, loading, and boundary conditions. A total load of 200 N was applied in axial (0°), oblique (45°), and lateral (90°) directions. The models were solved by the software NeiNastran 9.0 and transferred to the software FEMAP 10.0 to obtain the results that were visualized through von Mises and maximum principal stress maps. Model A (implants with 3.75 mm/abutment with 4.1 mm) exhibited the highest area of stress concentration with all loadings (axial, oblique, and lateral) for the implant and the abutment. All models presented the stress areas at the abutment level and at the implant/abutment interface. Models B (implant with 5.0 mm/abutment with 5.0 mm) and C (implant with 5.0 mm/abutment with 4.1 mm) presented minor areas of stress concentration and similar distribution pattern. For the cortical bone, low stress concentration was observed in the peri-implant region for models B and C in comparison to model A. The trabecular bone exhibited low stress that was well distributed in models B and C. Model A presented the highest stress concentration. Model B exhibited better stress distribution. There was no significant difference between the large-diameter implants (models B and C).

  20. Platform switching and bone platform switching.

    Science.gov (United States)

    Carinci, Francesco; Brunelli, Giorgio; Danza, Matteo

    2009-01-01

    Bone platform switching involves an inward bone ring in the coronal part of the implant that is in continuity with the alveolar bone crest. Bone platform switching is obtained by using a dental fixture with a reverse conical neck. A retrospective study was performed to evaluate the effectiveness of conventional vs reverse conical neck implants. In the period between May 2004 and November 2007, 86 patients (55 females and 31 males; median age, 53 years) were operated and 234 implants were inserted: 40 and 194 were conventional vs reverse conical neck implants, respectively. Kaplan-Meier algorithm and Cox regression were used to detect those variables associated with the clinical outcome. No differences in survival and success rates were detected between conventional vs reverse conical neck implants alone or in combination with any of the studied variables. Although bone platform switching leads to several advantages, no statistical difference in alveolar crest resorption is detected in comparison with reverse conical neck implants. We suppose that the proximity of the implant abutment junction to the alveolar crestal bone gives no protection against the microflora contained in the micrograph. Additional studies on larger series and a combination of platform switching and bone platform switching could lead to improved clinical outcomes.

  1. Platform for the study of virtual task-oriented motion and its evaluation by EEG and EMG biopotentials.

    Science.gov (United States)

    Figueroa-Garcia, Ivan; Aguilar-Leal, Omar; Hernandez-Reynoso, Ana G; Madrigal, Jimena; Fuentes, Rita Q; Huegel, Joel C; Garcia-Gonzalez, Alejandro

    2014-01-01

    This paper presents a platform to study the relationship between upper limb kinematic and biopotential measurements. The platform comprises of a haptic joystick, biopotential acquisition systems and 3D rendered virtual tasks that require user interaction. The haptic joystick, named TeeR, reproduces the pronation-supination and flexion-extension movements of the human arm, which are directly mapped to a 2D graphic display. The biopotential acquisition system is able to record electroencephalography (EEG) and electromyography (EMG) signals and synchronize them with kinematic data obtained from the Tee-R. The 3D virtual tasks are designed to obtain performance measurements from the user interaction. We include an example that depicts the possibilities of application for the study of event-related (de)synchronization (ERD/ERS) based on EEG during motor tasks.

  2. Public Service Television in a Multi-Platform Environment: A Comparative Study in Finland and Israel

    Directory of Open Access Journals (Sweden)

    Oranit Klein Shagrir

    2014-12-01

    Full Text Available Cultural and economic transformations have encouraged television companies to turn their attention to multi-platform practices so as to increase their compatibility with the changing media environment. While digital media provide public service broadcasting (PSB institutions with new opportunities for meeting their public commitments and maintaining their relevance in national media systems, PSB is also faced with additional challenges. One of these is the tension between public service values on the one hand and digital technologies and practices on the other. In this article we discuss how Finnish and Israeli PSB managers and producers perceive the opportunities and challenges of multi-platform production. In both countries public service broadcasting is striving for public legitimacy and relevance in a changing technological environment. However, the two countries currently find themselves at quite different stages: Israel has a struggling public service agency, while Finland boasts a strong broadcasting company.

  3. Definitions of love in a sample of British women: an empirical study using Q methodology.

    Science.gov (United States)

    Watts, Simon; Stenner, Paul

    2014-09-01

    Social psychological research has increasingly acknowledged that any pretensions to a singular theory of love should be replaced with a concern about its affirmation and what people actually say and do in love's name. Lee's (1977) love styles research and Sternberg's (1995) theory of love as a story are prime examples. Despite traditional definitions of love in western cultures being dominated by feminine images and tales of gender difference, however, the personal definitions and experiences of women have received comparatively little empirical attention, particularly in recent years and despite some well-documented changes in their cultural circumstances. This study remedies that situation through presentation of a Q methodological study in which a convenience sample of 59 British women were asked to Q sort 54 single-word descriptors of love to define love as they had experienced it. Factor analysis of the resulting Q sorts revealed six distinct definitions of love, interpreted as 'attraction, passion & romance', 'unconditional love', 'sex & fun', 'friendship & spirituality', 'a permanent commitment', and 'separate people, separate lives'. The six definitions are then discussed in terms of their allegiance to traditionally feminine and/or masculine values and as a means of highlighting the changing face of Britain's relational culture.

  4. Migration of legacy applications to a CORBA platform: a case study

    OpenAIRE

    Konstantas, Dimitri

    1996-01-01

    An important problem that many large organizations face today concerns the support and evolution of their large (legacy) information systems. In this paper we present an approach for migrating large and interdependent legacy information systems to CORBA based platforms. Our approach allows continuous availability of the information systems, minimal manpower for the implementation and preservation of the autonomy of the independent information systems. The information systems of ABB AG serve a...

  5. Facebook as an academic learning platform: A case study in Mathematics

    OpenAIRE

    Paolo Pellizzari

    2012-01-01

    The paper discusses the impact of the use of Facebook as a supporting learning platform for a course in Mathematics at the undergraduate level. After the examination of some critical issues of Facebook in a learning framework, we analyze data on the usage the page (total reach and number of engaged users) and the results of a survey taken by 217 students. Their appreciation for Facebook in such a context is stark and improvements of qualitative aspects of academic performance are perceived. S...

  6. Platform image processing to study the structural properties of retinal vessel

    Directory of Open Access Journals (Sweden)

    Miguel Ángel MERCHÁN

    2013-05-01

    Full Text Available This paper presents a technological platform specialized in assessing retinal vessel caliber and describing the relationship of the results obtained to cardiovascular risk. Retinal circulation is an area of active research by numerous groups, and there is general experimental agreement on the analysis of the patterns of the retinal blood vessels in the normal human retina. The development of automated tools designed to improve performance and decrease interobserver variability, therefore, appears necessary. 

  7. Fluid dynamic design and experimental study of an aspirated temperature measurement platform used in climate observation

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Jie, E-mail: yangjie396768@163.com [Key Laboratory for Aerosol-Cloud-Precipitation of China Meteorological Administration, Nanjing 210044 (China); School of Atmospheric Physics, Nanjing University of Information Science and Technology, Nanjing 210044 (China); Liu, Qingquan [Jiangsu Key Laboratory of Meteorological Observation and Information Processing, Nanjing 210044 (China); Jiangsu Collaborative Innovation Center on Atmospheric Environment and Equipment Technology, Nanjing 210044 (China); Dai, Wei [School of Atmospheric Physics, Nanjing University of Information Science and Technology, Nanjing 210044 (China); Ding, Renhui [Jiangsu Meteorological Observation Center, Nanjing 210008 (China)

    2016-08-15

    Due to the solar radiation effect, current air temperature sensors inside a thermometer screen or radiation shield may produce measurement errors that are 0.8 °C or higher. To improve the observation accuracy, an aspirated temperature measurement platform is designed. A computational fluid dynamics (CFD) method is implemented to analyze and calculate the radiation error of the aspirated temperature measurement platform under various environmental conditions. Then, a radiation error correction equation is obtained by fitting the CFD results using a genetic algorithm (GA) method. In order to verify the performance of the temperature sensor, the aspirated temperature measurement platform, temperature sensors with a naturally ventilated radiation shield, and a thermometer screen are characterized in the same environment to conduct the intercomparison. The average radiation errors of the sensors in the naturally ventilated radiation shield and the thermometer screen are 0.44 °C and 0.25 °C, respectively. In contrast, the radiation error of the aspirated temperature measurement platform is as low as 0.05 °C. This aspirated temperature sensor allows the radiation error to be reduced by approximately 88.6% compared to the naturally ventilated radiation shield, and allows the error to be reduced by a percentage of approximately 80% compared to the thermometer screen. The mean absolute error and root mean square error between the correction equation and experimental results are 0.032 °C and 0.036 °C, respectively, which demonstrates the accuracy of the CFD and GA methods proposed in this research.

  8. Initial Study of an Effective Fast-Time Simulation Platform for Unmanned Aircraft System Traffic Management

    Science.gov (United States)

    Xue, Min; Rios, Joseph

    2017-01-01

    Small Unmanned Aerial Vehicles (sUAVs), typically 55 lbs and below, are envisioned to play a major role in surveilling critical assets, collecting important information, and delivering goods. Large scale small UAV operations are expected to happen in low altitude airspace in the near future. Many static and dynamic constraints exist in low altitude airspace because of manned aircraft or helicopter activities, various wind conditions, restricted airspace, terrain and man-made buildings, and conflict-avoidance among sUAVs. High sensitivity and high maneuverability are unique characteristics of sUAVs that bring challenges to effective system evaluations and mandate such a simulation platform different from existing simulations that were built for manned air traffic system and large unmanned fixed aircraft. NASA's Unmanned aircraft system Traffic Management (UTM) research initiative focuses on enabling safe and efficient sUAV operations in the future. In order to help define requirements and policies for a safe and efficient UTM system to accommodate a large amount of sUAV operations, it is necessary to develop a fast-time simulation platform that can effectively evaluate requirements, policies, and concepts in a close-to-reality environment. This work analyzed the impacts of some key factors including aforementioned sUAV's characteristics and demonstrated the importance of these factors in a successful UTM fast-time simulation platform.

  9. Zero-gravity cloud physics laboratory: Candidate experiments definition and preliminary concept studies

    Science.gov (United States)

    Eaton, L. R.; Greco, R. V.; Hollinden, A. B.

    1973-01-01

    The candidate definition studies on the zero-g cloud physics laboratory are covered. This laboratory will be an independent self-contained shuttle sortie payload. Several critical technology areas have been identified and studied to assure proper consideration in terms of engineering requirements for the final design. Areas include chambers, gas and particle generators, environmental controls, motion controls, change controls, observational techniques, and composition controls. This unique laboratory will allow studies to be performed without mechanical, aerodynamics, electrical, or other type techniques to support the object under study. This report also covers the candidate experiment definitions, chambers and experiment classes, laboratory concepts and plans, special supporting studies, early flight opportunities and payload planning data for overall shuttle payload requirements assessments.

  10. Validation study of a computer-based open surgical trainer: SimPraxis® simulation platform

    Directory of Open Access Journals (Sweden)

    Tran LN

    2013-03-01

    Full Text Available Linh N Tran,1 Priyanka Gupta,2 Lauren H Poniatowski,2 Shaheen Alanee,3 Marc A Dall’Era,4 Robert M Sweet21Department of Internal Medicine, Loma Linda University, Loma Linda, CA, 2Department of Urology, University of Minnesota, Minneapolis, MN, 3Urology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, 4Department of Urology, University of California, Davis, CA, USABackground: Technological advances have dramatically changed medical education, particularly in the era of work-hour restrictions, which increasingly highlights a need for novel methods to teach surgical skills. The purpose of this study was to evaluate the validity of a novel, computer-based, interactive, cognitive simulator for training surgeons to perform pelvic lymph node dissection (PLND.Methods: Eight prostate cancer experts evaluated the content of the simulator. Contextual aspects of the simulator were rated on a five-point Likert scale. The experts and nine first-year residents completed a simulated PLND. Time and deviations were logged, and the results were compared between experts and novices using the Mann–Whitney test.Results: Before training, 88% of the experts felt that a validated simulator would be useful for PLND training. After testing, 100% of the experts felt that it would be more useful than standard video training. Eighty-eight percent stated that they would like to see the simulator in the curriculum of residency programs and 56% thought it would be useful for accreditation purposes. The experts felt that the simulator aided in overall understanding, training indications, concepts and steps of the procedure, training how to use an assistant, and enhanced the knowledge of anatomy. Median performance times taken by experts and interns to complete a PLND procedure on the simulator were 12.62 and 23.97 minutes, respectively. Median deviation from the incorporated procedure pathway for experts was 24.5 and was 89 for novices

  11. ITS Platform

    DEFF Research Database (Denmark)

    Tøfting, Svend; Lahrmann, Harry; Agerholm, Niels

    2014-01-01

    Aalborg University and two local companies have over the past four years developed and tested an ITS Platform, which can be used for communication with cars and for providing a number of services to the drivers. The purpose has been to perform a technological test of the possible use of a hidden ...... not have to be very intelligent. This is gradually taken over by applications on smart phones. The ITS Platform with 425 test drivers is now completely developed and can be used for technological testing of e.g. payment systems.......Aalborg University and two local companies have over the past four years developed and tested an ITS Platform, which can be used for communication with cars and for providing a number of services to the drivers. The purpose has been to perform a technological test of the possible use of a hidden...

  12. Knowledge of the definition of euthanasia: study with doctors and caregivers of Alzheimer's disease patients.

    Science.gov (United States)

    Vilela, Luciana Pricoli; Caramelli, Paulo

    2009-01-01

    Euthanasia is an increasingly debated subject among specialized professionals and also among lay people, even in countries such as Brazil where it is not authorized. It is questionable, however, if the concept of euthanasia is well known by these persons. The goal of this study was to investigate knowledge about the definition of euthanasia by family caregivers of patients with dementia and by specialized physicians and also to investigate their personal opinion on this topic. We prospectively interviewed 30 physicians from three different medical specialties and 40 family caregivers of patients with Alzheimer's disease using a structured questionnaire. Two clinical vignettes were also presented to the physicians in order to ascertain their personal opinion about euthanasia. Among the caregivers, 10 (25.0%) knew the correct definition of euthanasia. Regarding their personal view, nine (22.5%) were in favor, while 20 (50.0%) were against. The remaining 11 (27.5%) caregivers were unable to define their position. Among the physicians, 19 (63.3%) gave a coherent answer regarding the definition of euthanasia. When they were presented with the clinical vignettes, less than 50% of them were in favor of euthanasia. The definition of euthanasia was unknown by most of the lay individuals and also by one third of the physicians. Although it is not officially approved in Brazil, a small proportion of family caregivers and also of specialized physicians would be in favor of the practice of euthanasia.

  13. Using Social Media, Online Social Networks, and Internet Search as Platforms for Public Health Interventions: A Pilot Study.

    Science.gov (United States)

    Huesch, Marco D; Galstyan, Aram; Ong, Michael K; Doctor, Jason N

    2016-06-01

    To pilot public health interventions at women potentially interested in maternity care via campaigns on social media (Twitter), social networks (Facebook), and online search engines (Google Search). Primary data from Twitter, Facebook, and Google Search on users of these platforms in Los Angeles between March and July 2014. Observational study measuring the responses of targeted users of Twitter, Facebook, and Google Search exposed to our sponsored messages soliciting them to start an engagement process by clicking through to a study website containing information on maternity care quality information for the Los Angeles market. Campaigns reached a little more than 140,000 consumers each day across the three platforms, with a little more than 400 engagements each day. Facebook and Google search had broader reach, better engagement rates, and lower costs than Twitter. Costs to reach 1,000 targeted users were approximately in the same range as less well-targeted radio and TV advertisements, while initial engagements-a user clicking through an advertisement-cost less than $1 each. Our results suggest that commercially available online advertising platforms in wide use by other industries could play a role in targeted public health interventions. © Health Research and Educational Trust.

  14. A testing platform for durability studies of polymers and fiber-reinforced polymer composites under concurrent hygrothermo-mechanical stimuli.

    Science.gov (United States)

    Gomez, Antonio; Pires, Robert; Yambao, Alyssa; La Saponara, Valeria

    2014-12-11

    The durability of polymers and fiber-reinforced polymer composites under service condition is a critical aspect to be addressed for their robust designs and condition-based maintenance. These materials are adopted in a wide range of engineering applications, from aircraft and ship structures, to bridges, wind turbine blades, biomaterials and biomedical implants. Polymers are viscoelastic materials, and their response may be highly nonlinear and thus make it challenging to predict and monitor their in-service performance. The laboratory-scale testing platform presented herein assists the investigation of the influence of concurrent mechanical loadings and environmental conditions on these materials. The platform was designed to be low-cost and user-friendly. Its chemically resistant materials make the platform adaptable to studies of chemical degradation due to in-service exposure to fluids. An example of experiment was conducted at RT on closed-cell polyurethane foam samples loaded with a weight corresponding to ~50% of their ultimate static and dry load. Results show that the testing apparatus is appropriate for these studies. Results also highlight the larger vulnerability of the polymer under concurrent loading, based on the higher mid-point displacements and lower residual failure loads. Recommendations are made for additional improvements to the testing apparatus.

  15. Crossover versus Stabilometric Platform for the Treatment of Balance Dysfunction in Parkinson’s Disease: A Randomized Study

    Directory of Open Access Journals (Sweden)

    G. Frazzitta

    2015-01-01

    Full Text Available Balance dysfunctions are a major challenge in the treatment of Parkinson’s disease (PD. Previous studies have shown that rehabilitation can play a role in their treatment. In this study, we have compared the efficacy of two different devices for balance training: stabilometric platform and crossover. We have enrolled 60 PD patients randomly assigned to two groups. The first one (stabilometric group performed a 4-week cycle of balance training, using the stabilometric platform, whereas the second one (crossover group performed a 4-week cycle of balance training, using the crossover. The outcome measures used were Unified Parkinson’s Disease Rating Scale (UPDRS part II, Berg Balance Scale (BBS, Timed Up and Go (TUG, and Six Minutes Walking Test (6MWT. Results showed that TUG, BBS, and UPDRS II improved in both groups. There was not difference in the efficacy of the two balance treatments. Patients in both groups improved also the meters walked in the 6MWT at the end of rehabilitation, but the improvement was better for patients performing crossover training. Our results show that the crossover and the stabilometric platform have the same effect on balance dysfunction of Parkinsonian patients, while crossover gets better results on the walking capacity.

  16. ITS Platform

    DEFF Research Database (Denmark)

    Tøfting, Svend; Lahrmann, Harry; Agerholm, Niels

    2014-01-01

    Aalborg University and two local companies have over the past four years developed and tested an ITS Platform, which can be used for communication with cars and for providing a number of services to the drivers. The purpose has been to perform a technological test of the possible use of a hidden ...... not have to be very intelligent. This is gradually taken over by applications on smart phones. The ITS Platform with 425 test drivers is now completely developed and can be used for technological testing of e.g. payment systems....

  17. An experimental study on the mechanical properties of rat brain tissue using different stress-strain definitions.

    Science.gov (United States)

    Karimi, Alireza; Navidbakhsh, Mahdi

    2014-07-01

    There are different stress-strain definitions to measure the mechanical properties of the brain tissue. However, there is no agreement as to which stress-strain definition should be employed to measure the mechanical properties of the brain tissue at both the longitudinal and circumferential directions. It is worth knowing that an optimize stress-strain definition of the brain tissue at different loading directions may have implications for neuronavigation and surgery simulation through haptic devices. This study is aimed to conduct a comparative study on different results are given by the various definitions of stress-strain and to recommend a specific definition when testing brain tissues. Prepared cylindrical samples are excised from the parietal lobes of rats' brains and experimentally tested by applying load on both the longitudinal and circumferential directions. Three stress definitions (second Piola-Kichhoff stress, engineering stress, and true stress) and four strain definitions (Almansi-Hamel strain, Green-St. Venant strain, engineering strain, and true strain) are used to determine the elastic modulus, maximum stress and strain. The highest non-linear stress-strain relation is observed for the Almansi-Hamel strain definition and it may overestimate the elastic modulus at different stress definitions at both the longitudinal and circumferential directions. The Green-St. Venant strain definition fails to address the non-linear stress-strain relation using different definitions of stress and triggers an underestimation of the elastic modulus. The results suggest the application of the true stress-true strain definition for characterization of the brain tissues mechanics since it gives more accurate measurements of the tissue's response using the instantaneous values.

  18. Following User Pathways: Cross Platform and Mixed Methods Analysis in Social Media Studies

    DEFF Research Database (Denmark)

    Hall, Margeret; Mazarakis, Athanasios; Peters, Isabella

    2016-01-01

    is the mixed method approach (e.g. qualitative and quantitative methods) in order to better understand how users and society interacts online. The workshop 'Following User Pathways' brings together a community of researchers and professionals to address methodological, analytical, conceptual, and technological......Social media and the resulting tidal wave of available data have changed the ways and methods researchers analyze communities at scale. But the full potential for social scientists (and others) is not yet achieved. Despite the popularity of social media analysis in the past decade, few researchers...... challenges and opportunities of cross-platform, mixed method analysis in social media ecosystems....

  19. Test and Experiment Study on Synchronous Cooperative Design System Over Networked Manufacturing Platform

    Institute of Scientific and Technical Information of China (English)

    LUO Yabo; ZHENG Li; ZOU Shiwei; ZHAO Liang

    2006-01-01

    Based on the analysis on the previous research in virtual manufacturing and virtual enterprises, this paper provides a novel architecture of networked manufacturing system around the cooperative design. The key technologies for synchronous cooperative design in networked manufacturing platform, such as the cooperative mechanism, cooperative rules, control authority conveyed, cooperative efficiency, are detailed, with which a synchronous cooperative design system is developed. Due to the cooperative efficiency is the major bottleneck of the synchronous cooperative design over Internet, this research details the test and experiment to demonstrate the practicality of the system. Finally the advantages of the system are illustrated compared with current software tools.

  20. Platform computing

    CERN Multimedia

    2002-01-01

    "Platform Computing releases first grid-enabled workload management solution for IBM eServer Intel and UNIX high performance computing clusters. This Out-of-the-box solution maximizes the performance and capability of applications on IBM HPC clusters" (1/2 page) .

  1. The emerging science of quantitative imaging biomarkers terminology and definitions for scientific studies and regulatory submissions.

    Science.gov (United States)

    Kessler, Larry G; Barnhart, Huiman X; Buckler, Andrew J; Choudhury, Kingshuk Roy; Kondratovich, Marina V; Toledano, Alicia; Guimaraes, Alexander R; Filice, Ross; Zhang, Zheng; Sullivan, Daniel C

    2015-02-01

    The development and implementation of quantitative imaging biomarkers has been hampered by the inconsistent and often incorrect use of terminology related to these markers. Sponsored by the Radiological Society of North America, an interdisciplinary group of radiologists, statisticians, physicists, and other researchers worked to develop a comprehensive terminology to serve as a foundation for quantitative imaging biomarker claims. Where possible, this working group adapted existing definitions derived from national or international standards bodies rather than invent new definitions for these terms. This terminology also serves as a foundation for the design of studies that evaluate the technical performance of quantitative imaging biomarkers and for studies of algorithms that generate the quantitative imaging biomarkers from clinical scans. This paper provides examples of research studies and quantitative imaging biomarker claims that use terminology consistent with these definitions as well as examples of the rampant confusion in this emerging field. We provide recommendations for appropriate use of quantitative imaging biomarker terminological concepts. It is hoped that this document will assist researchers and regulatory reviewers who examine quantitative imaging biomarkers and will also inform regulatory guidance. More consistent and correct use of terminology could advance regulatory science, improve clinical research, and provide better care for patients who undergo imaging studies. © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

  2. Development of a sandwiched microarray platform for studying the interactions of antibiotics with Staphylococcus aureus.

    Science.gov (United States)

    Liu, Xia; Lei, Zhen; Liu, Dianjun; Wang, Zhenxin

    2016-04-21

    It still confronts an outstanding challenge to screen efficient antibacterial drugs from millions of potential antibiotic candidates. In this regard, a sandwiched microarray platform has been developed to culture live bacteria and carry out high-throughput screening antibacterial drugs. The optimized lectin-hydrogel microarray can be used as an efficient bacterial capturing and culturing platform, which is beneficial to identify spots and collect data. At the same time, a matching drug-laden polyacrylamide microarray with Luria-Bertani (LB) culture medium can be generated automatically and accurately by using a standard non-contacting procedure. A large number of microscale culture chambers (more than 100 individual samples) between two microarrays can be formed by linking two aligned hydrogel spots using LB culture medium, where live bacteria can be co-cultured with drug candidates. Using Staphylococcus aureus (S. aureus) and four well-known antibiotics (amoxicillin, vancomycin, streptomycin and chloramphenicol) as model system, the MIC (minimum inhibitory concentration) values of the antibiotics can be determined by the drug induced change of bacterial growth, and the results demonstrate that the MIC values of amoxicillin, vancomycin and streptomycin are 1.7 μg mL(-1), 3.3 μg mL(-1) and 10.3 μg mL(-1), respectively.

  3. Knowledge of the definition of euthanasia: study with doctors and caregivers of Alzheimer's disease patients

    OpenAIRE

    Luciana Pricoli Vilela; Paulo Caramelli

    2009-01-01

    BACKGROUND: Euthanasia is an increasingly debated subject among specialized professionals and also among lay people, even in countries such as Brazil where it is not authorized. It is questionable, however, if the concept of euthanasia is well known by these persons. OBJECTIVE: The goal of this study was to investigate knowledge about the definition of euthanasia by family caregivers of patients with dementia and by specialized physicians and also to investigate their personal opinion on this...

  4. A study of characteristics of intercity transportation systems. Phase 1: Definition of transportation comparison methodology

    Science.gov (United States)

    English, J. M.; Smith, J. L.; Lifson, M. W.

    1978-01-01

    The objectives of this study are: (1) to determine a unified methodological framework for the comparison of intercity passenger and freight transportation systems; (2) to review the attributes of existing and future transportation systems for the purpose of establishing measures of comparison. These objectives were made more specific to include: (1) development of a methodology for comparing long term transportation trends arising from implementation of various R&D programs; (2) definition of value functions and attribute weightings needed for further transportation goals.

  5. Distributed situation awareness in complex collaborative systems: A field study of bridge operations on platform supply vessels.

    Science.gov (United States)

    Sandhåland, Hilde; Oltedal, Helle A; Hystad, Sigurd W; Eid, Jarle

    2015-06-01

    This study provides empirical data about shipboard practices in bridge operations on board a selection of platform supply vessels (PSVs). Using the theoretical concept of distributed situation awareness, the study examines how situation awareness (SA)-related information is distributed and coordinated at the bridge. This study thus favours a systems approach to studying SA, viewing it not as a phenomenon that solely happens in each individual's mind but rather as something that happens between individuals and the tools that they use in a collaborative system. Thus, this study adds to our understanding of SA as a distributed phenomenon. Data were collected in four field studies that lasted between 8 and 14 days on PSVs that operate on the Norwegian continental shelf and UK continental shelf. The study revealed pronounced variations in shipboard practices regarding how the bridge team attended to operational planning, communication procedures, and distracting/interrupting factors during operations. These findings shed new light on how SA might decrease in bridge teams during platform supply operations. The findings from this study emphasize the need to assess and establish shipboard practices that support the bridge teams' SA needs in day-to-day operations.

  6. Disentangling Competition Among Platform Driven Strategic Groups

    DEFF Research Database (Denmark)

    Kazan, Erol; Tan, Chee-Wee; Lim, Eric

    2015-01-01

    In platform-driven markets, competitive advantage is derived from superior platform design and configurations. For this reason, platform owners strive to create unique and inimitable platform configurals to maintain and extend their competitiveness within network economies. To disentangle firm...... competition within platform-driven markets, we opted for the UK mobile payment market as our empirical setting. By embracing the theoretical lens of strategic groups and digital platforms, this study supplements prior research by deriving a taxonomy of platform-driven strategic groups that is grounded...... on competitive attributes of platform- driven markets; namely interfirm modularity and strategic linkages....

  7. Disentangling Competition Among Platform Driven Strategic Groups

    DEFF Research Database (Denmark)

    Kazan, Erol; Tan, Chee-Wee; Lim, Eric

    2015-01-01

    competition within platform-driven markets, we opted for the UK mobile payment market as our empirical setting. By embracing the theoretical lens of strategic groups and digital platforms, this study supplements prior research by deriving a taxonomy of platform-driven strategic groups that is grounded......In platform-driven markets, competitive advantage is derived from superior platform design and configurations. For this reason, platform owners strive to create unique and inimitable platform configurals to maintain and extend their competitiveness within network economies. To disentangle firm...... on competitive attributes of platform- driven markets; namely interfirm modularity and strategic linkages....

  8. The relation of metabolic syndrome according to five definitions to cardiovascular risk factors - a population-based study

    Directory of Open Access Journals (Sweden)

    Lai Ming-May

    2009-12-01

    Full Text Available Abstract Background Although National Cholesterol Education Program (NCEP, International Diabetes Federation (IDF, American Heart Association and National Heart, Lung and Blood Institute (AHA/NHLBI, World Health Organization (WHO, and the European Group for the Study of Insulin Resistance (EGIR definitions of metabolic syndrome (MetS have been commonly used by studies, little is known about agreement among these five definitions. We examined the agreement among these five definitions and explored their relationship with risk factors of cardiovascular disease in a Taiwan population. Methods A total of 1305 subjects aged 40 years and over in Taiwan were analyzed. Biomedical markers and anthropometric indices were measured. Agreement among definitions was determined by the kappa statistic. Logistic regression models were fit to estimate the odds of a high cardiovascular risk group for five definitions of MetS. Results The agreement among the NCEP, IDF, and AHA/NHLBI definitions was from substantial to very good, and agreement between the WHO and EGIR definitions was also substantial. All MetS definitions were significantly associated prevalence of microalbuminuria, elevated highly sensitive CRP (hs-CRP, and arterial stiffness only in women. In men, MetS by NCEP and AHA/NHLBI was associated with elevated level of hs-CRP and arterial stiffness. MetS by WHO and EGIR were significantly associated with microalbuminuria. And MetS by WHO was the only MetS definition that significantly associated with prevalence of arterial stiffness (OR: 2.75, 95% CI: 1.22-6.19. Conclusions The associations of these five definitions with cardiovascular risk factors were similar in women, and it was evident that the five definitions performed better in women than in men, with higher ORs observed in relation to arterial stiffness, elevated hs-CRP, and higher Framingham risk scores.

  9. Infinispan data grid platform definitive guide

    CERN Document Server

    Santos, Wagner Roberto dos

    2015-01-01

    This practical guide is intended for those who want to learn how to build extremely scalable applications. This book is easy to read and is aimed at Java enterprise developers with a solid knowledge of Java. However, no previous coding experience with Infinispan is required.

  10. Miniaturized Analytical Platforms From Nanoparticle Components: Studies in the Construction, Characterization, and High-Throughput Usage of These Novel Architectures

    Energy Technology Data Exchange (ETDEWEB)

    Andrew David Pris

    2003-08-05

    The scientific community has recently experienced an overall effort to reduce the physical size of many experimental components to the nanometer size range. This size is unique as the characteristics of this regime involve aspects of pure physics, biology, and chemistry. One extensively studied example of a nanometer sized experimental component, which acts as a junction between these three principle scientific theologies, is deoxyribonucleic acid (DNA) or ribonucleic acid (RNA). These biopolymers not only contain the biological genetic guide to code for the production of life-sustaining materials, but are also being probed by physicists as a means to create electrical circuits and furthermore as controllable architectural and sensor motifs in the chemical disciplines. Possibly the most common nano-sized component between these sciences are nanoparticles composed of a variety of materials. The cross discipline employment of nanoparticles is evident from the vast amount of literature that has been produced from each of the individual communities within the last decade. Along these cross-discipline lines, this dissertation examines the use of several different types of nanoparticles with a wide array of surface chemistries to understand their adsorption properties and to construct unique miniaturized analytical and immunoassay platforms. This introduction will act as a literature review to provide key information regarding the synthesis and surface chemistries of several types of nanoparticles. This material will set the stage for a discussion of assembling ordered arrays of nanoparticles into functional platforms, architectures, and sensors. The introduction will also include a short explanation of the atomic force microscope that is used throughout the thesis to characterize the nanoparticle-based structures. Following the Introduction, four research chapters are presented as separate manuscripts. Chapter 1 examines the self-assembly of polymeric nanoparticles

  11. Kilovoltage Rotational External Beam Radiotherapy on a Breast Computed Tomography Platform: A Feasibility Study

    Energy Technology Data Exchange (ETDEWEB)

    Prionas, Nicolas D.; McKenney, Sarah E. [Department of Radiology, University of California, Davis, Medical Center, Sacramento, California (United States); Stern, Robin L. [Department of Radiation Oncology, University of California, Davis, Medical Center, Sacramento, California (United States); Boone, John M., E-mail: jmboone@ucdavis.edu [Department of Radiology, University of California, Davis, Medical Center, Sacramento, California (United States)

    2012-10-01

    Purpose: To demonstrate the feasibility of a dedicated breast computed tomography (bCT) platform to deliver rotational kilovoltage (kV) external beam radiotherapy (RT) for partial breast irradiation, whole breast irradiation, and dose painting. Methods and Materials: Rotational kV-external beam RT using the geometry of a prototype bCT platform was evaluated using a Monte Carlo simulator. A point source emitting 178 keV photons (approximating a 320-kVp spectrum with 4-mm copper filtration) was rotated around a 14-cm voxelized polyethylene disk (0.1 cm tall) or cylinder (9 cm tall) to simulate primary and primary plus scattered photon interactions, respectively. Simulations were also performed using voxelized bCT patient images. Beam collimation was varied in the x-y plane (1-14 cm) and in the z-direction (0.1-10 cm). Dose painting for multiple foci, line, and ring distributions was demonstrated using multiple rotations with varying beam collimation. Simulations using the scanner's native hardware (120 kVp filtered by 0.2-mm copper) were validated experimentally. Results: As the x-y collimator was narrowed, the two-dimensional dose profiles shifted from a cupped profile with a high edge dose to an increasingly peaked central dose distribution with a sharp dose falloff. Using a 1-cm beam, the cylinder edge dose was <7% of the dose deposition at the cylinder center. Simulations using 120-kVp X-rays showed distributions similar to the experimental measurements. A homogeneous dose distribution (<2.5% dose fluctuation) with a 20% decrease in dose deposition at the cylinder edge (i.e., skin sparing) was demonstrated by weighted summation of four dose profiles using different collimation widths. Simulations using patient bCT images demonstrated the potential for treatment planning and image-guided RT. Conclusions: Rotational kV-external beam RT for partial breast irradiation, dose painting, and whole breast irradiation with skin sparing is feasible on a bCT platform

  12. Genetic distance as an alternative to physical distance for definition of gene units in association studies.

    Science.gov (United States)

    Rodriguez-Fontenla, Cristina; Calaza, Manuel; Gonzalez, Antonio

    2014-05-28

    Some association studies, as the implemented in VEGAS, ALIGATOR, i-GSEA4GWAS, GSA-SNP and other software tools, use genes as the unit of analysis. These genes include the coding sequence plus flanking sequences. Polymorphisms in the flanking sequences are of interest because they involve cis-regulatory elements or they inform on untyped genetic variants trough linkage disequilibrium. Gene extensions have customarily been defined as ±50 Kb. This approach is not fully satisfactory because genetic relationships between neighbouring sequences are a function of genetic distances, which are only poorly replaced by physical distances. Standardized recombination rates (SRR) from the deCODE recombination map were used as units of genetic distances. We searched for a SRR producing flanking sequences near the ±50 Kb offset that has been common in previous studies. A SRR≥2 was selected because it led to gene extensions with median length=45.3 Kb and the simplicity of an integer value. As expected, boundaries of the genes defined with the ±50 Kb and with the SRR≥2 rules were rarely concordant. The impact of these differences was illustrated with the interpretation of top association signals from two large studies including many hits and their detailed analysis based in different criteria. The definition based in genetic distance was more concordant with the results of these studies than the based in physical distance. In the analysis of 18 top disease associated loci form the first study, the SRR≥2 genes led to a fully concordant interpretation in 17 loci; the ±50 Kb genes only in 6. Interpretation of the 43 putative functional genes of the second study based in the SRR≥2 definition only missed 4 of the genes, whereas the based in the ±50 Kb definition missed 10 genes. A gene definition based on genetic distance led to results more concordant with expert detailed analyses than the commonly used based in physical distance. The genome coordinates for each

  13. Competing Definitions of Schizophrenia: What Can Be Learned From Polydiagnostic Studies?

    DEFF Research Database (Denmark)

    Jansson, Lennart Bertil; Parnas, Josef

    2006-01-01

    The contemporary diagnoses of schizophrenia (sz)—Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) and International Classification of Diseases,10th Revision (ICD-10)—are widely considered as important scientific achievements. However, these algorithms were not a prod......The contemporary diagnoses of schizophrenia (sz)—Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) and International Classification of Diseases,10th Revision (ICD-10)—are widely considered as important scientific achievements. However, these algorithms were...... not a product of explicit conceptual analyses and empirical studies but defined through consensus with the purpose of improving reliability. The validity status of current definitions and of their predecessors remains unclear. The so-called "polydiagnostic approach" applies different definitions of a disorder...

  14. Design and Development of System Platform of "Study on Relationship between Natural Phenology and Climate Change" Based on WEB and GIS

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    [Objective] The research aimed to study design and development of system platform of "study on relationship between natural phenology and climate change" based on WEB and GIS. [Method] Relied on the technologies of WEB and GIS, a set of system platform of "study on relationship between natural phenology and climate change" was developed based on the hybrid architecture of C/S (Client/Server) and B/S (Browser/Server). Moreover, its establishing process and functional module were detailedly introduced. [Resul...

  15. Multidisciplinary collaborative gross tumour volume definition for lung cancer radiotherapy: a prospective study.

    Science.gov (United States)

    Hollingdale, Abigail E; Roques, Tom W; Curtin, John; Martin, W M Craig; Horan, Gail; Barrett, Ann

    2011-12-07

    Variability in gross tumour volume (GTV) definition is a major source of systematic error in conformal radiotherapy. This prospective study assesses the role of multidisciplinary collaboration between oncologists and radiologists in defining lung cancer volumes. Twenty patients with non-small cell lung cancer due to receive three-dimensional conformal radiotherapy formed the study population. GTVs were defined by a radiologist (GTVrad) and an oncologist (GTVonc) using available clinical information and imaging. A collaborative meeting was then held to agree on a final, common GTV (GTVfin) to be used for treatment planning, and differences analysed. The collaboration changed the GTV in 19/20 patients with a total of 50 regions being edited. Changes made were categorized as (a) differentiation of tumour from atelectasis or ground glass shadowing, (b) separation of tumour from vasculature, and (c) defining mediastinal extent of tumour. Oncologists were more confident in the GTVfin than the GTVonc. The radiologist took longer to define the GTV than the oncologist. Real-time collaborative GTV definition by a radiologist and oncologist is practical and feasible. This approach allows specific areas of uncertainty to be categorized and focussed on, reducing systematic error in GTV definition. The physician's approach to risk and decision making for each patient may also play a role.

  16. Transoral robotic thyroidectomy: a preclinical feasibility study using the da Vinci Xi platform.

    Science.gov (United States)

    Russell, Jonathon O; Noureldine, Salem I; Al Khadem, Mai G; Chaudhary, Hamad A; Day, Andrew T; Kim, Hoon Yub; Tufano, Ralph P; Richmon, Jeremy D

    2017-02-02

    Transoral thyroid surgery allows the surgeon to conceal incisions within the oral cavity without significantly increasing the amount of required dissection. TORT provides an ideal scarless, midline access to the thyroid gland and bilateral central neck compartments. This approach, however, presents multiple technical challenges. Herein, we present our experience using the latest generation robotic surgical system to accomplish transoral robotic thyroidectomy (TORT). In two human cadavers, the da Vinci Xi surgical system (Intuitive Surgical, Sunnyvale, CA, USA) was used to complete TORT. Total thyroidectomy and bilateral central neck dissection was successfully completed in both cadavers. The da Vinci Xi platform offered several technologic advantages over previous robotic generations including overhead docking, narrower arms, and improved range of motion allowing for improved execution of previously described TORT techniques.

  17. Feasibility Study of Implementing a Mobile Collaborative Information Platform for International Safeguards Inspections

    Energy Technology Data Exchange (ETDEWEB)

    Gastelum, Zoe N.; Gitau, Ernest TN; Doehle, Joel R.; Toomey, Christopher M.

    2014-09-30

    In response to the growing pervasiveness of mobile technologies such as tablets and smartphones, the International Atomic Energy Agency and the U.S. Department of Energy National Laboratories have been exploring the potential use of these platforms for international safeguards activities. Specifically of interest are information systems (software, and accompanying servers and architecture) deployed on mobile devices to increase the situational awareness and productivity of an IAEA safeguards inspector in the field, while simultaneously reducing paperwork and pack weight of safeguards equipment. Exploratory development in this area has been met with skepticism regarding the ability to overcome technology deployment challenges for IAEA safeguards equipment. This report documents research conducted to identify potential challenges for the deployment of a mobile collaborative information system to the IAEA, and proposes strategies to mitigate those challenges.

  18. Feasibility Study of Implementing a Mobile Collaborative Information Platform for International Safeguards Inspections

    Energy Technology Data Exchange (ETDEWEB)

    Gastelum, Zoe N. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Gitau, Ernest T. N. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Doehle, Joel R. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Toomey, Christopher M. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2014-09-01

    In response to the growing pervasiveness of mobile technologies such as tablets and smartphones, the International Atomic Energy Agency and the U.S. Department of Energy National Laboratories have been exploring the potential use of these platforms for international safeguards activities. Specifically of interest are information systems (software, and accompanying servers and architecture) deployed on mobile devices to increase the situational awareness and productivity of an IAEA safeguards inspector in the field, while simultaneously reducing paperwork and pack weight of safeguards equipment. Exploratory development in this area has been met with skepticism regarding the ability to overcome technology deployment challenges for IAEA safeguards equipment. This report documents research conducted to identify potential challenges for the deployment of a mobile collaborative information system to the IAEA, and proposes strategies to mitigate those challenges.

  19. Study on validation method of visible imagery spatial resolution of imager on geostationary platform

    Institute of Scientific and Technical Information of China (English)

    Qiang Guo

    2006-01-01

    @@ Based on the analysis for the main elements of the total modulation transfer function (MTF) of imager on geostationary platform, the precise evaluation for its low spatial frequency spectrum has been achieved.Meanwhile, it is pointed out that the main cause of imagery spatial resolution lower than the designed value is the "slight defocus" of imager focal plane array (FPA). The validation method for visible imagery spatial resolution is proposed based on the analysis of defocused optical system model and edge-spread-function (ESF), the relative error is less than 7% after alleviating stray light effects. This method has been applied in the in-orbit ground testing of FY-2C geostationary meteorological satellite successfully.

  20. Smart sensor: a platform for an interactive human physiological state recognition study

    Directory of Open Access Journals (Sweden)

    Andrej Gorochovik

    2013-03-01

    Full Text Available This paper describes a concept of making interactive human state recognition systems based on smart sensor design. The token measures on proper ADC signal processing had significantly lowered the interference level. A more reliable way of measuring human skin temperature was offered by using Maxim DS18B20 digital thermometers. They introduced a more sensible response to temperature changes compared to previously used analog LM35 thermometers. An adaptive HR measuring algorithm was introduced to suppress incorrect ECG signal readings caused by human muscular activities. User friendly interactive interface for touch sensitive GLCD screen was developed to present real time physiological data readings both in numerals and graphics. User was granted an ability to dynamically customize data processing methods according to his needs. Specific procedures were developed to simplify physiological state recording for further analysis. The introduced physiological data sampling and preprocessing platform was optimized to be compatible with “ATmega Oscilloscope” PC data collecting and visualizing software.

  1. Small scale experimental study of the dynamic response of a tension leg platform wind turbine

    DEFF Research Database (Denmark)

    Hansen, Anders Mandrup; Laugesen, Robert; Bredmose, Henrik

    2014-01-01

    A floating Tension Leg Platform (TLP) wind turbine was constructed at scale 1/200 and its dynamic response was analysed experimentally in co-directional wind and waves. The wind turbine was Froude scaled and a new rotor was designed to yield maximum power and Froude scaled thrust at the low model...... Reynolds number. Physical limitations due to the large scaling ratio further meant that some structural adjustments were necessary. Nacelle and floater accelerations were measured by means of two accelerometers. The TLP was moored with four different tendon configurations and exposed to different constant...... increases the occurrence of slack tendons and the magnitude of the pitch accelerations. In a robust commercial design, however, slack tendons must be avoided. The experiments demonstrate the ability of the wind turbine model and the experimental setup to give insight to the dynamic characteristics...

  2. A Study on Crack Detection with Modal Parameters of A Jacket Platform

    Institute of Scientific and Technical Information of China (English)

    张兆德; 王德禹

    2004-01-01

    Crack detection procedures by different modal parameters are analyzed for identifying a crack and its location and magnitude in a jacket platform. The first ten natural frequencies and modal shapes of the jacket models are obtained by numerical experiments based on NASTRAN Code. A crack at different locations and of different magnitudes is imposed in the model at the underwater beams. Then, the modal evaluation parameters are calculated numerically, to illustrate the evaluation of modal parameter criteria used in jacket crack detection. The sensitivities of different modal parameters to different cracks are analyzed. A new technique is presented for predicting the approximate location of a breakage in the absence of the data of an intact model. This method can be used to detect a crack in underwater members by use of in complete mode shapes of the top members of the jacket.

  3. Exploring Stakeholder Definitions within the Aerospace Industry: A Qualitative Case Study

    Science.gov (United States)

    Hebert, Jonathan R.

    A best practice in the discipline of project management is to identify all key project stakeholders prior to the execution of a project. When stakeholders are properly identified, they can be consulted to provide expert advice on project activities so that the project manager can ensure the project stays within the budget and schedule constraints. The problem addressed by this study is that managers fail to properly identify key project stakeholders when using stakeholder theory because there are multiple conflicting definitions for the term stakeholder. Poor stakeholder identification has been linked to multiple negative project outcomes such as budget and schedules overruns, and this problem is heightened in certain industries such as aerospace. The purpose of this qualitative study was to explore project managers' and project stakeholders' perceptions of how they define and use the term stakeholder within the aerospace industry. This qualitative exploratory single-case study had two embedded units of analysis: project managers and project stakeholders. Six aerospace project managers and five aerospace project stakeholders were purposively selected for this study. Data were collected through individual semi-structured interviews with both project managers and project stakeholders. All data were analyzed using Yin's (2011) five-phased cycle approach for qualitative research. The results indicated that the aerospace project managers and project stakeholder define the term stakeholder as "those who do the work of a company." The participants build upon this well-known concept by adding that, "a company should list specific job titles" that correspond to their company specific-stakeholder definition. Results also indicated that the definition of the term stakeholder is used when management is assigning human resources to a project to mitigate or control project risk. Results showed that project managers tended to include the customer in their stakeholder definitions

  4. A Study of A Web 2.0-based Educative Platform

    Directory of Open Access Journals (Sweden)

    Jang-Ruey Tzeng

    2009-08-01

    Full Text Available Despite the booming information technology, traditionally one-way teaching/learning mode remains dominating the class. Although there are some education institutes take information system as a supplementary tool and some courses has been taught online, teaching materials in class are in the main the written ones, and online forms of teaching still concentrate in one classroom assisted by programmed media. Generally speaking, textbooks and classrooms are the major vehicles of the education in Taiwan with a main purpose to have face-to-face conveyance of knowledge. The conventional means to education has been criticized as monotonous, depressing and restraining [1]. To orient the situation toward the future that education is a service system with students rather than tutors at the center [2], this paper looks at the application potentials of Web 2.0 technology to be integrated into the teaching frameworks. With the core value of Web 2.0 technology that lies in the empowerment of internet users from sole capabilities to download and reading into one that can upload and share, the paper seeks to construct an educative platform supported by the Web 2.0 technology with a view to transform conventional forms of tutors-centered education and improve teaching and learning effects. The paper is structurally divided into four sections. Section 1 gives a brief on the Web 2.0 technology. Section 2 frame the current gaps left by digital educative platforms. Section 3 is to construct a preliminary educative model supported by the Web 2.0 technology with four elements-website users, contents, virtual community and tools-put into the flowchart. A discussion and recommendation for further research lies in Section 4, which also serves as a conclusion.

  5. Platform Constellations

    DEFF Research Database (Denmark)

    Staykova, Kalina Stefanova; Damsgaard, Jan

    2016-01-01

    messaging apps KakaoTalk and LINE, we are able to gain valuable insights about the nature of these new constructions and to capture and synthesize their main characteristics in a framework. Our results show that platform constellations possess unique innovative capabilities, which can improve users......’ acquisition and users’ engagement rates as well as unlock new sources of value creation and diversify revenue streams....

  6. Multi –Media Educational Communication Strategies for English. A Case Study of an Online Chat Room for EFL as Platform of Applied Language Learning

    National Research Council Canada - National Science Library

    Fee-Alexandra HASSE

    2012-01-01

    .... A chat room can serve as a platform for such situations with speech communication. The first part of this paper introduces a general methodology for the development and study of conversational learning process...

  7. EVALUATION OF FREE PLATFORMS FOR DELIVERY OF MASSIVE OPEN ONLINE COURSES (MOOCS

    Directory of Open Access Journals (Sweden)

    Airton ZANCANARO

    2017-01-01

    Full Text Available For the hosting, management and delivery of Massive Open Online Courses (MOOC it is necessary a technological infrastructure that supports it. Various educational institutions do not have or do not wish to invest in such a structure, possibly because MOOCs are not yet part of official programs of universities, but initiatives by a particular teacher or a research group. Focusing on this problem, this study seeks to identify platforms that make it possible to create, host and provide courses free of charges for the offeror; find in the respective literature, the basic requirements for MOOC platforms and to evaluate the platforms based on the raised requirements. In order to identify the platforms, information was sought in scientific articles and websites dealing with the comparison of platforms and listing the existing MOOC providers. For the definition of evaluation requirements, there was a search in the Web of Science and Scopus databases, looking for the term "Massive Open Online Courses". After applying some filters, 62 works that address platforms and technology were selected for analysis. As a result there is the identification of six platforms that allow the free supply of courses, the proposal for 14 requirements for reviewing them and a frame containing the evaluation of the identified platforms. This assessment is important since it brings knowledge as a basis for selecting a platform that is the most suitable one in terms of the chosen structure and method to store, manage and deliver courses in MOOC format.

  8. The Exploring Nature of Definitions and Classifications of Language Learning Strategies (LLSs) in the Current Studies of Second/Foreign Language Learning

    Science.gov (United States)

    Fazeli, Seyed Hossein

    2011-01-01

    This study aims to explore the nature of definitions and classifications of Language Learning Strategies (LLSs) in the current studies of second/foreign language learning in order to show the current problems regarding such definitions and classifications. The present study shows that there is not a universal agreeable definition and…

  9. Integrated Semantics Service Platform for the Internet of Things: A Case Study of a Smart Office

    Directory of Open Access Journals (Sweden)

    Minwoo Ryu

    2015-01-01

    Full Text Available The Internet of Things (IoT allows machines and devices in the world to connect with each other and generate a huge amount of data, which has a great potential to provide useful knowledge across service domains. Combining the context of IoT with semantic technologies, we can build integrated semantic systems to support semantic interoperability. In this paper, we propose an integrated semantic service platform (ISSP to support ontological models in various IoT-based service domains of a smart city. In particular, we address three main problems for providing integrated semantic services together with IoT systems: semantic discovery, dynamic semantic representation, and semantic data repository for IoT resources. To show the feasibility of the ISSP, we develop a prototype service for a smart office using the ISSP, which can provide a preset, personalized office environment by interpreting user text input via a smartphone. We also discuss a scenario to show how the ISSP-based method would help build a smart city, where services in each service domain can discover and exploit IoT resources that are wanted across domains. We expect that our method could eventually contribute to providing people in a smart city with more integrated, comprehensive services based on semantic interoperability.

  10. Integrated semantics service platform for the Internet of Things: a case study of a smart office.

    Science.gov (United States)

    Ryu, Minwoo; Kim, Jaeho; Yun, Jaeseok

    2015-01-19

    The Internet of Things (IoT) allows machines and devices in the world to connect with each other and generate a huge amount of data, which has a great potential to provide useful knowledge across service domains. Combining the context of IoT with semantic technologies, we can build integrated semantic systems to support semantic interoperability. In this paper, we propose an integrated semantic service platform (ISSP) to support ontological models in various IoT-based service domains of a smart city. In particular, we address three main problems for providing integrated semantic services together with IoT systems: semantic discovery, dynamic semantic representation, and semantic data repository for IoT resources. To show the feasibility of the ISSP, we develop a prototype service for a smart office using the ISSP, which can provide a preset, personalized office environment by interpreting user text input via a smartphone. We also discuss a scenario to show how the ISSP-based method would help build a smart city, where services in each service domain can discover and exploit IoT resources that are wanted across domains. We expect that our method could eventually contribute to providing people in a smart city with more integrated, comprehensive services based on semantic interoperability.

  11. [Study of sharing platform of web-based enhanced extracorporeal counterpulsation hemodynamic waveform data].

    Science.gov (United States)

    Huang, Mingbo; Hu, Ding; Yu, Donglan; Zheng, Zhensheng; Wang, Kuijian

    2011-12-01

    Enhanced extracorporeal counterpulsation (EECP) information consists of both text and hemodynamic waveform data. At present EECP text information has been successfully managed through Web browser, while the management and sharing of hemodynamic waveform data through Internet has not been solved yet. In order to manage EECP information completely, based on the in-depth analysis of EECP hemodynamic waveform file of digital imaging and communications in medicine (DICOM) format and its disadvantages in Internet sharing, we proposed the use of the extensible markup language (XML), which is currently the Internet popular data exchange standard, as the storage specification for the sharing of EECP waveform data. Then we designed a web-based sharing system of EECP hemodynamic waveform data via ASP. NET 2.0 platform. Meanwhile, we specifically introduced the four main system function modules and their implement methods, including DICOM to XML conversion module, EECP waveform data management module, retrieval and display of EECP waveform module and the security mechanism of the system.

  12. Power Extension Package (PEP) system definition extension, orbital service module systems analysis study. Volume 10: PEP project plan

    Science.gov (United States)

    1979-01-01

    Contents: project plan summary; project and mission objectives; related studies and technology support activities; technical summary; management; procurement approach; project definition items and schedule; resources; management review; controlled items; and safety, reliability, and quality assurance.

  13. Biofuel Drying - Literature Study and Definitions, Concepts and Terms; Torkning av biobraensle - litteraturstudie samt definitioner, begrepp och termer

    Energy Technology Data Exchange (ETDEWEB)

    Sanati, Mehri; Faghihi, Mostafa

    2001-09-01

    The report contains one section with definitions and explications of terms in the field of drying of biofuels. The second section presents, in english, the result of a literature study in the same subject, based on 90 literature references.

  14. Study of the potential of amphiphilic conetworks based on poly(2-ethyl-2-oxazoline) as new platforms for delivery of drugs with limited solubility.

    Science.gov (United States)

    Kostova, Bistra; Ivanova-Mileva, Krasimira; Rachev, Dimitar; Christova, Darinka

    2013-03-01

    Thermoresponsive amphiphilic conetworks comprising poly(2-ethyl-2-oxazoline) (PEtOx), 2-hydroxyethyl methacrylate, and 2-hydroxypropyl acrylate segments have been studied as new platforms for delivery of drug with limited solubility. Series of conetworks of varied composition were synthesized and swelling kinetics in aqueous media and ethanol were followed. The platforms were loaded with the hydrophobic drug ibuprofen by swelling in its ethanol solution. The structure and properties of the drug carriers were investigated by scanning electron microscopy and differential scanning calorimetry. The release kinetics profiles of ibuprofen from the studied platform were established. The investigation proved the feasibility of the PEtOx-based amphiphilic conetworks as highly effective platforms for sustained ibuprofen delivery.

  15. Social Media as a Platform for Information About Diabetes Foot Care: A Study of Facebook Groups.

    Science.gov (United States)

    Abedin, Tasnima; Al Mamun, Mohammad; Lasker, Mohammad A A; Ahmed, Syed Walid; Shommu, Nusrat; Rumana, Nahid; Turin, Tanvir C

    2017-02-01

    Diabetes is one of the most challenging chronic health conditions in the current era. Diabetes-related foot problems need proper patient education, and social media could a play role to disseminate proper information. A systematic search was performed on Facebook groups using the key words "diabetes foot care", "diabetes foot", "diabetes foot management" and "podiatric care". The search resulted in 57 groups and detailed activity information was collected from those groups. Usefulness of each relevant post was determined. Regression analysis was performed to explore the factors associated with the level of usefulness of diabetes foot care-related Facebook groups. Our search resulted in a total of 16 eligible diabetes foot care-related Facebook groups with a total of 103 eligible posts. The average number of group members for the selected groups were 265.75 with an interquartile range of 3.5-107.75. Of the total 103 timeline posts, 45.6% posts were categorized as useful, while the remaining posts were not useful. Top mentioned diabetes foot care practice was "Checking feet daily". Multivariable logistic regression analysis showed that the level of usefulness of diabetes foot care-related Facebook groups were significantly associated with the type of posts and no association was found with presence of "likes" and presence of comment. Facebook being a widely used social networking system, patient welfare organizations, doctors, nurses and podiatrists could use this platform to provide support to educating diabetes patients and their caregivers by disseminating useful and authentic knowledge and information related to diabetes foot care. Copyright © 2016 Canadian Diabetes Association. Published by Elsevier Inc. All rights reserved.

  16. An LC-IMS-MS Platform Providing Increased Dynamic Range for High-Throughput Proteomic Studies

    Energy Technology Data Exchange (ETDEWEB)

    Baker, Erin Shammel; Livesay, Eric A.; Orton, Daniel J.; Moore, Ronald J.; Danielson, William F.; Prior, David C.; Ibrahim, Yehia M.; Lamarche, Brian L.; Mayampurath, Anoop M.; Schepmoes, Athena A.; Hopkins, Derek F.; Tang, Keqi; Smith, Richard D.; Belov, Mikhail E.

    2010-02-05

    A high-throughput approach and platform using 15 minute reversed-phase capillary liquid chromatography (RPLC) separations in conjunction with ion mobility spectrometry-mass spectrometry (IMS-MS) measurements was evaluated for the rapid analysis of complex proteomics samples. To test the separation quality of the short LC gradient, a sample was prepared by spiking twenty reference peptides at varying concentrations from 1 ng/mL to 10 µg/mL into a tryptic digest of mouse blood plasma and analyzed with both a LC-Linear Ion Trap Fourier Transform (FT) MS and LC-IMS-TOF MS. The LC-FT MS detected thirteen out of the twenty spiked peptides that had concentrations ≥100 ng/mL. In contrast, the drift time selected mass spectra from the LC-IMS-TOF MS analyses yielded identifications for nineteen of the twenty peptides with all spiking level present. The greater dynamic range of the LC-IMS-TOF MS system could be attributed to two factors. First, the LC-IMS-TOF MS system enabled drift time separation of the low concentration spiked peptides from the high concentration mouse peptide matrix components, reducing signal interference and background, and allowing species to be resolved that would otherwise be obscured by other components. Second, the automatic gain control (AGC) in the linear ion trap of the hybrid FT MS instrument limits the number of ions that are accumulated to reduce space charge effects, but in turn limits the achievable dynamic range compared to the TOF detector.

  17. [Importance of the definition of urban zones in the study of cancer risk factors].

    Science.gov (United States)

    Pottier, D; Launoy, G; Le Coutour, X; Dugleux, G; Gignoux, M

    1989-01-01

    1446 cases of colorectal cancer have been collected in the Registry of digestive tract tumours in the "Department" of Calvados with the aim of studying the effect of residential location on cancer incidence. The risk-ratio was different in males and in females and between different types of urban areas. Using the urban category of "Zone de Peuplement Industriel ou Urbain" (ZPIU) increased the observed risk-ratio (1.6 for males, 1.2 for females), and enabled definition of homogeneous populations. This improved classification, thus allowed a more discriminating analysis of the effect of residential location on risk of cancer in both sexes.

  18. Residential buffer, perceived neighborhood, and individual activity space: New refinements in the definition of exposure areas - The RECORD Cohort Study.

    Science.gov (United States)

    Perchoux, Camille; Chaix, Basile; Brondeel, Ruben; Kestens, Yan

    2016-07-01

    Neighborhood effects on health have been widely investigated; yet the definition of neighborhoods is usually arbitrary. This study analyses how disparities in environmental exposure according to urbanicity vary when considering a home-centered network-buffer, the perceived residential neighborhood, or the activity space. Exposures to the density of destinations and proportion of green space were compared for three spatial definitions of exposure areas, overall and stratified by urbanicity of the residence. Environmental exposure levels and gradients by urbanicity were found to vary depending on the spatial definition of the exposure area.

  19. Defining the Field: Revisiting the ACA 1995 Definition of Communication Studies.

    Science.gov (United States)

    Korn, Charles J.; Morreale, Sherwyn P.; Boileau, Don M.

    2000-01-01

    Presents results of a survey of Association for Communication Administration (ACA) members concerning their awareness and use of the 1995 ACA Definition of the Field of Communication. Finds that 40% of administrators who responded were unaware of the definition. Urges the need to further promote the definition of the field. (NH)

  20. Case Study of Integrating an Offshore Wind Farm with Offshore Oil and Gas Platforms and with an Onshore Electrical Grid

    Directory of Open Access Journals (Sweden)

    Wei He

    2013-01-01

    Full Text Available This research project explored the technical feasibility of utilizing an offshore wind farm as a supplementary power source to several electrical grids of offshore oil and gas platforms and providing surplus power to an onshore grid. Three case studies comprising wind farms rated at 20 MW, 100 MW, and 1000 MW have been studied with the focus on (i the operation benefits of CO2/NOx emission reduction, (ii the electrical grid stability, and (iii the technical implementation feasibility. The proposed 20 MW, 100 MW, and 1000 MW wind farm cases are theoretically feasible in terms of the selected technical criteria, although further detailed design operational studies, and economical analysis are required.

  1. Comparative Effectiveness of 3-Dimensional vs 2-Dimensional and High-Definition vs Standard-Definition Neuroendoscopy: A Preclinical Randomized Crossover Study

    Science.gov (United States)

    Hughes-Hallett, Archie; Cundy, Thomas P.; Di Marco, Aimee; Pratt, Philip; Nandi, Dipankar; Darzi, Ara; Yang, Guang-Zhong

    2013-01-01

    BACKGROUND: Although the potential benefits of 3-dimensional (3-D) vs 2-dimensional (2-D) and high-definition (HD) vs standard-definition (SD) endoscopic visualization have long been recognized in other surgical fields, such endoscopes are generally considered too large and bulky for use within the brain. The recent development of 3-D and HD neuroendoscopes may therefore herald improved depth perception, better appreciation of anatomic details, and improved overall surgical performance. OBJECTIVE: To compare simultaneously the effectiveness of 3-D vs 2-D and HD vs SD neuroendoscopy. METHODS: Ten novice neuroendoscopic surgeons were recruited from a university hospital. A preclinical randomized crossover study design was adopted to compare 3-D vs 2-D and HD vs SD neuroendoscopy. The primary outcomes were time to task completion and accuracy. The secondary outcomes were perceived task workload using the NASA (National Aeronautics and Space Administration) Task Load Index and subjective impressions of the endoscopes using a 5-point Likert scale. RESULTS: Time to task completion was significantly shorter when using the 3-D vs the 2-D neuroendoscopy (P = .001), and accuracy of probe placement was significantly greater when using the HD vs the SD neuroendoscopy (P = .009). We found that 3-D endoscopy significantly improved perceived depth perception (P < .001), HD endoscopy significantly improved perceived image quality (P < .001), and both improved participants’ overall impression (P < .001). CONCLUSION: Three-dimensional neuroendoscopy and HD neuroendoscopy have differing but complementary effects on surgical performance, suggesting that neither alone can completely compensate for the lack of the other. There is therefore strong preclinical evidence to justify 3-D HD neuroendoscopy. ABBREVIATIONS: HD, high definition SD, standard definition PMID:24220007

  2. Parametric study on the effects of pile inclination angle on the response of batter piles in offshore jacket platforms

    Science.gov (United States)

    Aminfar, Ali; Ahmadi, Hamid; Aminfar, Mohammad Hossein

    2016-06-01

    Offshore jacket-type platforms are attached to the seabed by long batter piles. In this paper, results from a finite element analysis, verified against experimental data, are used to study the effect of the pile's inclination angle, and its interaction with the geometrical properties of the pile and the geotechnical characteristics of the surrounding soil on the behavior of the inclined piles supporting the jacket platforms. Results show that the inclination angle is one of the main parameters affecting the behavior of an offshore pile. We investigated the effect of the inclination angle on the maximum von Mises stress, maximum von Mises elastic strain, maximum displacement vector sum, maximum displacement in the horizontal direction, and maximum displacement in the vertical direction. The pile seems to have an operationally optimal degree of inclination of approximately 5°. By exceeding this value, the instability in the surrounding soil under applied loads grows extensively in all the geotechnical properties considered. Cohesive soils tend to display poorer results compared to grained soils.

  3. A New Mixed Signal Platform to Study the Accuracy/Complexity Trade-Off of DPD Algorithms

    Directory of Open Access Journals (Sweden)

    Hanan Thabet

    2016-12-01

    Full Text Available The increase in bandwidth of Power Amplifier (PA input signals has led to the development of more complex behavioral PA models. Most recent models such as the Generalized Memory Polynomial (1 or the Polyharmonic distortion modeling (2 can be used to design very performant but complex and thus very consuming Digital Predistortion algorithms (DPDs. On the other hand, with earlier simpler models, the precision of the DPD may not be enough. The model order is also the major factor influencing the requirements in terms of bandwidth and dynamic range of the digitized signal in the feedback loop of a typical Power amplification system architecture: the higher the order, the more information is needed for identification. This paper describes a new mixed signal simulation platform developed to study the complexity vs. accuracy trade-off from the DPD point of view. The platform estimates the accuracy of the DPD and the power consumption (including the consumption of the DPD itself of the whole feedback loop, by comparing various PA models with various DPDs algorithms. Contrary to older works, measuring the accuracy on the open loop without DPD and estimating the complexity in theoretical number of operations, our goal is to be able to estimate with precision the performances and the power consumption of the whole amplification system (PA + DPD + DAC + feedback loop for optimization of DPD algorithms.

  4. Developing a Millifluidic Platform for the Synthesis of Ultrasmall Nanoclusters: Ultrasmall Copper Nanoclusters as a Case Study

    Energy Technology Data Exchange (ETDEWEB)

    Biswas, Sanchita; Miller, Jeffrey T; Li, Yuehao; Nandakumar, Krishnaswamy; Kumar, Challa S.S.R.

    2012-02-02

    The future of lab-on-a-chip devices for the synthesis of nanomaterials hinges on the successful development of high-throughput methods with better control over their size. While significant effort in this direction mainly focuses on developing “difficult to fabricate” complex microfluidic reactors, scant attention has been paid to the “easy to fabricate” and simple millifluidic systems that could provide the required control as well as high throughput. By utilizing numerical simulation of fluids within the millifluidic space at different flow rates, the results presented here show velocity profiles and residence time distributions similar to the case of microfluidics. By significantly reducing the residence time and residence time distribution, a continuous flow synthesis of ultrasmall copper nanoclusters (UCNCs) with exceptional colloidal stability is achieved. In-situ synchrotron-radiation-based X-ray absorption spectroscopy (XAS) reveal that the as-prepared clusters are about 1 nm, which is further supported by transmission electron microscopy and UV–vis spectroscopy studies. The clusters reported here are the smallest ever produced using a lab-on-a-chip platform. When supported on silica, they are found to efficiently catalyze C–H oxidation reactions, hitherto unknown to be catalyzed by Cu. This work suggests that a millifluidic platform can be an inexpensive, versatile, easy-to-use, and powerful tool for nanoparticle synthesis in general, and more specifically for ultrasmall nanoclusters (UNCs).

  5. A Cas9 Ribonucleoprotein Platform for Functional Genetic Studies of HIV-Host Interactions in Primary Human T Cells

    Directory of Open Access Journals (Sweden)

    Judd F. Hultquist

    2016-10-01

    Full Text Available New genetic tools are needed to understand the functional interactions between HIV and human host factors in primary cells. We recently developed a method to edit the genome of primary CD4+ T cells by electroporation of CRISPR/Cas9 ribonucleoproteins (RNPs. Here, we adapted this methodology to a high-throughput platform for the efficient, arrayed editing of candidate host factors. CXCR4 or CCR5 knockout cells generated with this method are resistant to HIV infection in a tropism-dependent manner, whereas knockout of LEDGF or TNPO3 results in a tropism-independent reduction in infection. CRISPR/Cas9 RNPs can furthermore edit multiple genes simultaneously, enabling studies of interactions among multiple host and viral factors. Finally, in an arrayed screen of 45 genes associated with HIV integrase, we identified several candidate dependency/restriction factors, demonstrating the power of this approach as a discovery platform. This technology should accelerate target validation for pharmaceutical and cell-based therapies to cure HIV infection.

  6. Influence of strut inertia on the vibrations in initially symmetric Gough-Stewart Platforms-an analytical study

    Science.gov (United States)

    Afzali-Far, Behrouz; Andersson, Anette; Nilsson, Kristina; Lidström, Per

    2015-09-01

    Consideration of strut inertia can have significant influence on the modal behavior of a Gough-Stewart Platform (GSP). However, in the literature, the strut inertia has not yet been taken into account in its vibration study with a parametric approach. In this paper, we present a fully parametric approach to formulate the damped vibrations of GSPs taking into account the strut masses and moments of inertia for symmetric configurations. For the first time, a combined 6×6 equivalent inertia matrix (mass matrix), including both the inertia properties of the platform and the struts, is formulated parametrically. Subsequently, the eigenvectors and the damped eigenfrequencies are also parametrically developed in the Cartesian space. Furthermore, the conditions for the decoupled vibrations and the effect of strut inertia on these conditions are analytically investigated. With the aid of a reference GSP, the influence of the strut inertia on its modal behavior is systematically investigated. Accordingly, it is concluded that the parametric equations established in this paper can be directly employed in the analysis, optimization and control of GSPs in any application.

  7. An Examination of Which Implications New Media Platforms Can Have on Study Group Work and Learning Opportunities in the Environment of the Course Information Systems for Business

    DEFF Research Database (Denmark)

    Hougaard, Simone Quach; Trankjær, Mie Bohn; Schlichter, Bjarne Rerup

    2014-01-01

    for our analysis, three focus group interviews were conducted during February 2014 at Aarhus University among first semester Marketing and Management Communication students who had participated in the ISB course. Based on the findings it is evident that the use of New Media platforms is widely used......The Information Society is characterised by its technological development; the many New Media platforms offered on the World Wide Web have changed the communication culture from a traditional one-way transaction to a co-creation culture (Mangold and Faulds 2009). This paper investigates which...... implications New Media platforms – with special emphasis on Blackboard, Facebook, Google Docs and Dropbox – have on study group work in the environment of the course Information Systems for Business (ISB) at Aarhus University. Additionally, it is investigated which opportunities these platforms potentially...

  8. Coupled hydro-meteorological modelling on a HPC platform for high-resolution extreme weather impact study

    Science.gov (United States)

    Zhu, Dehua; Echendu, Shirley; Xuan, Yunqing; Webster, Mike; Cluckie, Ian

    2016-11-01

    Impact-focused studies of extreme weather require coupling of accurate simulations of weather and climate systems and impact-measuring hydrological models which themselves demand larger computer resources. In this paper, we present a preliminary analysis of a high-performance computing (HPC)-based hydrological modelling approach, which is aimed at utilizing and maximizing HPC power resources, to support the study on extreme weather impact due to climate change. Here, four case studies are presented through implementation on the HPC Wales platform of the UK mesoscale meteorological Unified Model (UM) with high-resolution simulation suite UKV, alongside a Linux-based hydrological model, Hydrological Predictions for the Environment (HYPE). The results of this study suggest that the coupled hydro-meteorological model was still able to capture the major flood peaks, compared with the conventional gauge- or radar-driving forecast, but with the added value of much extended forecast lead time. The high-resolution rainfall estimation produced by the UKV performs similarly to that of radar rainfall products in the first 2-3 days of tested flood events, but the uncertainties particularly increased as the forecast horizon goes beyond 3 days. This study takes a step forward to identify how the online mode approach can be used, where both numerical weather prediction and the hydrological model are executed, either simultaneously or on the same hardware infrastructures, so that more effective interaction and communication can be achieved and maintained between the models. But the concluding comments are that running the entire system on a reasonably powerful HPC platform does not yet allow for real-time simulations, even without the most complex and demanding data simulation part.

  9. 电力WebGIS平台研究%A Study on Power WebGIS Platform

    Institute of Scientific and Technical Information of China (English)

    王晓辉; 吴克河; 肖湘宁; 王延平

    2012-01-01

    In the informatization construction of power enterprises, the Web geographic information system (WebGIS) can transmit messages accurately and timely and assist the decision-making. In allusion to such problems existing in the WebGIS construction for power enterprises as complexity of power equipment models, slow updating speed of graphics, prolix user operation, in the spatial data organization a spatial power grid data model based on four dimensionalities, namely three-dimensional space and time dimension, and four space- divisions, namely the geographic space, equipment space, topological space and electro-physical space, is proposed. In the aspects of query and retrieval a semantic based cluster R-tree index and a multi-cache mechanism are put forward; in graphics rendering a rendering mode of background map tiles mixed with vectors of power equipments is offered; in graphics operation a mode similar to Google Map is adopted. Finally, a new archi- tecture for the implementation of power WebGIS platform is given.%基于Web的地理信息系统(Web geographic information system,WebGIS)在电力企业信息化建设中能够及时、准确地传递信息并辅助决策。针对电力WebGIS建设过程中存在的电力设施模型复杂、图形更新速度缓慢、用户操作繁琐等问题进行研究,在空间数据组织中提出了“四维四分”(“四维”指空间三维和时间维,“四分”指地理空间、设备空间、拓扑空间和电物理空间的空间四分)的电网空间数据模型,在查询检索方面提出了基于语义的聚类R-树索引和多级缓存机制,在图形渲染方面提出了背景地图瓦片和电力设施矢量混合渲染的方式,在图形操作方面采用类GoogleMap的模式,最后提出了电力webGIs平台实现的体系结构。

  10. A study on a micro-stepping drive system for space pointing platform

    Science.gov (United States)

    Yang, Shuang; Li, Bao-quan; Zhang, Xin

    2011-08-01

    Along with the continuous development of the research in the space exploration field, the precision rotation control system is widely utilized in a lot of payloads of the satellites. It is stepping motor cooperating with reduction gear wheel to accomplish the precision rotation in some pointing platforms of the camera used in the satellite. By contrast with that, the approach of this paper could precisely control the rotation angle of the stepping motor without using reduction gear wheel. Therefore, the size and the height of the instrument would be reduced base on simplifying the structural design. Moreover, it reduces the cost to some extent. In this paper, it is adopted that the digital signal processor (DSP) controller and bipolar constant current motor drive circuit UC3717 to make a high performance, high subdivision, miniature control system come true, which is used to drive two-phase hybrid stepping motor. The methods are applied by the driver system that sine cosine micro stepping and constant current chopper drive with a fixed chopper period. The driver system also supplies the functions that involve subdivision selection, clockwise rotation or counter clockwise rotation control, and over current or over voltage or under voltage or overload protection, and so on. The description in this paper also includes the total schematic design, the approach to get current table in different subdivision levels, the current control method in hybrid stepping motor, the way to reduce electro- magnetic interference (EMI) of the hybrid stepping motor. And the total schematic design contains the DSP controller, the communication interface of the driver system, the design of power driving circuit, the interface circuit between the electrical sources, the constant current chopper drive circuit for the two-phase hybrid stepping motor. At last, it is verified by some experimental investigations that the control system not only has miniature size, simplified system design

  11. Student involvement as a vehicle for empowerment: a case study of the student platform for engineering education development

    Science.gov (United States)

    Delaine, David A.; Seif-Naraghi, Sonya B.; Al-Haque, Shahed; Wojewoda, Nicolò; Meninato, Yvonne; DeBoer, Jennifer

    2010-08-01

    This paper examines the mission, structure and outputs of one organisation, the Student Platform for Engineering Education Development (SPEED), as a case study for how student-led organisations can use student involvement to promote and sustain student self-efficacy in an academic field. SPEED attracts young people to engineering through student participation in engineering education (EE). SPEED is a global, non-profit student organisation that functions as an interdisciplinary network to diversify dialogue, stimulate change and impact the development of EE and its effect on society. SPEED is directly attracting young people to engineering in various ways: the organisation of its keynote event, the Global Student Forum; facilitating interactions between globally minded, socially inclined engineers with aspirations to change the world; and through the global dissemination of SPEED's work and practices through broad and relevant channels. Short-term outcomes are highlighted here. This case study can serve as a model for student engagement and involvement in other disciplines.

  12. The management approach to the NASA space station definition studies at the Manned Spacecraft Center

    Science.gov (United States)

    Heberlig, J. C.

    1972-01-01

    The overall management approach to the NASA Phase B definition studies for space stations, which were initiated in September 1969 and completed in July 1972, is reviewed with particular emphasis placed on the management approach used by the Manned Spacecraft Center. The internal working organizations of the Manned Spacecraft Center and its prime contractor, North American Rockwell, are delineated along with the interfacing techniques used for the joint Government and industry study. Working interfaces with other NASA centers, industry, and Government agencies are briefly highlighted. The controlling documentation for the study (such as guidelines and constraints, bibliography, and key personnel) is reviewed. The historical background and content of the experiment program prepared for use in this Phase B study are outlined and management concepts that may be considered for future programs are proposed.

  13. Web platform using digital image processing and geographic information system tools: a Brazilian case study on dengue.

    Science.gov (United States)

    Brasil, Lourdes M; Gomes, Marília M F; Miosso, Cristiano J; da Silva, Marlete M; Amvame-Nze, Georges D

    2015-07-16

    the following steps: i. Obtain images from the eggs on an ovitrap's cardboards, with a microscope. ii. Apply a proposed image-processing-based semi-automatic counting system. The system we developed uses the Java programming language and the Java Server Faces technology. This is a framework suite for web applications development. This approach will allow a simple migration to any Operating System platform and future applications on mobile devices. iii. Collect and store all data into a Database (DB) and then georeference them in a GIS. The Database Management System used to develop the DB is based on PostgreSQL. The GIS will assist in the visualization and spatial analysis of digital maps, allowing the location of Dengue outbreaks in the region of study. This will also facilitate the planning, analysis, and evaluation of temporal and spatial epidemiology, as required by the Brazilian Health Care Control Center. iv. Deploy the SCSA-WEB, DB and GIS on a single Web platform. The statistical results obtained by DIP were satisfactory when compared with the SCSA-WEB's semi-automated eggs count. The results also indicate that the time spent in manual counting has being considerably reduced when using our fully automated DIP algorithm and semi-automated SCSA-WEB. The developed georeferencing Web platform proves to be of great support for future visualization with statistical and trace analysis of the disease. The analyses suggest the efficiency of our algorithm for automatic eggs counting, in terms of expediting the work of the laboratory technician, reducing considerably its time and error counting rates. We believe that this kind of integrated platform and tools can simplify the decision making process of the Brazilian Health Care Control Center.

  14. A study of TB-associated immune reconstitution inflammatory syndrome using the consensus case-definition.

    Science.gov (United States)

    Sharma, Surendra K; Dhooria, Sahajal; Barwad, Parag; Kadhiravan, Tamilarasu; Ranjan, Sanjay; Miglani, Sunita; Gupta, Deepak

    2010-06-01

    A considerable proportion of patients with HIV associated tuberculosis (TB) started on highly active antiretroviral therapy (HAART) develop immune reconstitution inflammatory syndrome (IRIS), which is difficult to diagnose in a resource-limited setting. In view of the recently proposed consensus case-definitions for TB-IRIS for use in resource-limited settings we undertook this study to describe the incidence and risk factors of TB associated IRIS in a tertiary care hospital and research centre in north India. Retrospective analysis of antiretroviral treatment (ART) naïve adults started on highly active ART (HAART) from June 2006 to September 2008 was done. Of the 627 patients studied, 237 (38%) had TB at the initiation of HAART. In total, 18 (7.5%) of 237 patients with TB at baseline had paradoxical TB-associated IRIS, and 12 (3%) of 390 patients without TB at baseline developed ART-associated TB. Most IRIS events occurred during the initial 30 days of HAART. Two patients developed TB-associated IRIS after 90 days of HAART. Using univariate analysis, low CD4+ cell count at baseline [64 (28-89) vs. 95 (52-150); P=0.009] and early initiation of HAART [33 (24-41) vs. 48 (35-61) days; PART-associated TB. A considerable proportion of patients on HAART develop TB-associated IRIS. The consensus case-definition is a useful tool in resource-limited settings for the diagnosis of TB- associated IRIS.

  15. Overlap of food addiction and substance use disorders definitions: analysis of animal and human studies.

    Science.gov (United States)

    Hone-Blanchet, Antoine; Fecteau, Shirley

    2014-10-01

    Food has both homeostatic and hedonic components, which makes it a potent natural reward. Food related reward could therefore promote an escalation of intake and trigger symptoms associated to withdrawal, suggesting a behavioral parallel with substance abuse. Animal and human theoretical models of food reward and addiction have emerged, raising further interrogations on the validity of a bond between Substance Use Disorders, as clinically categorized in the DSM 5, and food reward. These models propose that highly palatable food items, rich in sugar and/or fat, are overly stimulating to the brain's reward pathways. Moreover, studies have also investigated the possibility of causal link between food reward and the contemporary obesity epidemic, with obesity being potentiated and maintained due to this overwhelming food reward. Although natural rewards are a hot topic in the definition and categorization of Substance Use Disorders, proofs of concept and definite evidence are still inconclusive. This review focuses on available results from experimental studies in animal and human models exploring the concept of food addiction, in an effort to determine if it depicts a specific phenotype and if there is truly a neurobiological similarity between food addiction and Substance Use Disorders. It describes results from sugar, fat and sweet-fat bingeing in rodent models, and behavioral and neurobiological assessments in different human populations. Although pieces of behavioral and neurobiological evidence supporting a food addiction phenotype in animals and humans are interesting, it seems premature to conclude on its validity.

  16. Product Platform Screening at LEGO

    DEFF Research Database (Denmark)

    Mortensen, Niels Henrik; Steen Jensen, Thomas; Nielsen, Ole Fiil

    2012-01-01

    Product platforms offer great benefits to companies developing new products in highly competitive markets. Literature describes how a single platform can be designed from a technical point of view, but rarely mentions how the process begins. How do companies identify possible platform candidates...... after a few changes had been applied to the initial process layout. This case study shows how companies must focus on a limited selection of simultaneous projects in order to keep focus. Primary stakeholders must be involved from the very beginning, and short presentations of the platform concepts...

  17. Transparent Gap Filler Solution over a DVB-RCS2 Satellite Platform in a Railway Scenario: Performance Evaluation Study

    Directory of Open Access Journals (Sweden)

    Peppino Fazio

    2015-01-01

    Full Text Available In this work, a performance study of a system equipped with a transparent Gap Filler solution in a DVB-RCS2 satellite platform has been provided. In particular, a simulation model based on a 3-state Markov chain, overcoming the blockage status through the introduction of a transparent Gap Filler (using devices on both tunnel sides has been implemented. The handover time, due to switching mechanism between satellite and Gap Filler, has been taken into account. As reference scenario, the railway market has been considered, which is characterized by a N-LOS condition, due to service disruptions caused by tunnels, vegetation and buildings. The system performance, in terms of end-to-end delay, queue size and packet loss percentage, have been evaluated, in order to prove the goodness of communications in a real railroad path.

  18. Development and case study of a science-based software platform to support policy making on air quality

    Institute of Scientific and Technical Information of China (English)

    Yun Zhu; Yahweh Lao; Carey Jang; Chen-Jen Lin; Jia Xing; Shuxiao Wang; Joshua S.Fu

    2015-01-01

    This article describes the development and implementations of a novel software platform that supports real-time,science-based policy making on air quality through a user-friendly interface.The software,RSM-VAT,uses a response surface modeling (RSM) methodology and serves as a visualization and analysis tool (VAT) for three-dimensional air quality data obtained by atmospheric models.The software features a number of powerful and intuitive data visualization functions for illustrating the complex nonlinear relationship between emission reductions and air quality benefits.The case study of contiguous U.S.demonstrates that the enhanced RSM-VAT is capable of reproducing the air quality model results with Normalized Mean Bias <2% and assisting in air quality policy making in near real time.

  19. JOURNALISTIC ACTIVITY ON MOBILE PLATFORMS: A STUDY ON AUTOCHTHONOUS PRODUCTS AND CHANGES TO THE JOURNALIST’S PROFESSIONAL PROFILE

    Directory of Open Access Journals (Sweden)

    Suzana Barbosa

    2013-12-01

    Full Text Available This article is centred on a study of the empirical and theoretical-conceptual nature of autochthonous (original products for tablets, with a horizontal multiplatform logic, integrating the web, tablets, smartphones and PDF and page flip versions of printed editions in a dynamic, multimedia continuum launched as part of journalistic organizations’ strategies in compliance with journalistic convergence processes. The methodology includes a qualitative, empirical analysis of actual products (O Globo a Mais, Estadão Noite and Folha10 conducted in an ad hoc exploratory manner, associated to semi-structured interviews with editors and reporters. The results indicate changes to the profile of the professionals involved with production strategies for tablets, inserting new elements in autochthonous product narratives. A 3.0 transposition was simultaneously identified, as the exclusive content for tablet products is transferred to other platforms at a later date.

  20. Cognitive Aids for Role Definition (CARD) to improve interprofessional team crisis resource management: An exploratory study.

    Science.gov (United States)

    Renna, Tania Di; Crooks, Simone; Pigford, Ashlee-Ann; Clarkin, Chantalle; Fraser, Amy B; Bunting, Alexandra C; Bould, M Dylan; Boet, Sylvain

    2016-09-01

    This study aimed to assess the perceived value of the Cognitive Aids for Role Definition (CARD) protocol for simulated intraoperative cardiac arrests. Sixteen interprofessional operating room teams completed three consecutive simulated intraoperative cardiac arrest scenarios: current standard, no CARD; CARD, no CARD teaching; and CARD, didactic teaching. Each team participated in a focus group interview immediately following the third scenario; data were transcribed verbatim and qualitatively analysed. After 6 months, participants formed eight new teams randomised to two groups (CARD or no CARD) and completed a retention intraoperative cardiac arrest simulation scenario. All simulation sessions were video recorded and expert raters assessed team performance. Qualitative analysis of the 16 focus group interviews revealed 3 thematic dimensions: role definition in crisis management; logistical issues; and the "real life" applicability of CARD. Members of the interprofessional team perceived CARD very positively. Exploratory quantitative analysis found no significant differences in team performance with or without CARD (p > 0.05). In conclusion, qualitative data suggest that the CARD protocol clarifies roles and team coordination during interprofessional crisis management and has the potential to improve the team performance. The concept of a self-organising team with defined roles is promising for patient safety.

  1. The feasibility study of non-invasive fetal trisomy 18 and 21 detection with semiconductor sequencing platform.

    Directory of Open Access Journals (Sweden)

    Young Joo Jeon

    Full Text Available OBJECTIVE: Recent non-invasive prenatal testing (NIPT technologies are based on next-generation sequencing (NGS. NGS allows rapid and effective clinical diagnoses to be determined with two common sequencing systems: Illumina and Ion Torrent platforms. The majority of NIPT technology is associated with Illumina platform. We investigated whether fetal trisomy 18 and 21 were sensitively and specifically detectable by semiconductor sequencer: Ion Proton. METHODS: From March 2012 to October 2013, we enrolled 155 pregnant women with fetuses who were diagnosed as high risk of fetal defects at Xiamen Maternal & Child Health Care Hospital (Xiamen, Fujian, China. Adapter-ligated DNA libraries were analyzed by the Ion Proton™ System (Life Technologies, Grand Island, NY, USA with an average 0.3× sequencing coverage per nucleotide. Average total raw reads per sample was 6.5 million and mean rate of uniquely mapped reads was 59.0%. The results of this study were derived from BWA mapping. Z-score was used for fetal trisomy 18 and 21 detection. RESULTS: Interactive dot diagrams showed the minimal z-score values to discriminate negative versus positive cases of fetal trisomy 18 and 21. For fetal trisomy 18, the minimal z-score value of 2.459 showed 100% positive predictive and negative predictive values. The minimal z-score of 2.566 was used to classify negative versus positive cases of fetal trisomy 21. CONCLUSION: These results provide the evidence that fetal trisomy 18 and 21 detection can be performed with semiconductor sequencer. Our data also suggest that a prospective study should be performed with a larger cohort of clinically diverse obstetrics patients.

  2. Encapsulating Software Platform Logic by Aspect-Oriented Programming: A Case Study in Using Aspects for Language Portability

    NARCIS (Netherlands)

    Kats, L.C.; Visser, E.

    2010-01-01

    Software platforms such as the Java Virtual Machine or the CLR .NET virtual machine have their own ecosystem of a core programming language or instruction set, libraries, and developer community. Programming languages can target multiple software platforms to increase interoperability or to boost pe

  3. Encapsulating Software Platform Logic by Aspect-Oriented Programming: A Case Study in Using Aspects for Language Portability

    NARCIS (Netherlands)

    Kats, L.C.; Visser, E.

    2010-01-01

    Software platforms such as the Java Virtual Machine or the CLR .NET virtual machine have their own ecosystem of a core programming language or instruction set, libraries, and developer community. Programming languages can target multiple software platforms to increase interoperability or to boost

  4. Platform Performance and Challenges - using Platforms in Lego Company

    DEFF Research Database (Denmark)

    Munk, Lone; Mortensen, Niels Henrik

    2009-01-01

    This article studies the performance and challenges of using nine implemented product platforms in LEGO Company. Most of these do produce results, but do not meet their goals due to challenges in their usage in the daily product. The main challenges are that the platforms are not being used...

  5. Final definition and preliminary design study for the initial atmospheric cloud physics laboratory, a Spacelab mission payload

    Science.gov (United States)

    1976-01-01

    The following areas related to the final definition and preliminary design study of the initial atmospheric cloud physics laboratory (ACPL) were covered: (1) proposal organization, personnel, schedule, and project management, (2) proposed configurations, (3) study objectives, (4) ACPL experiment program listing and description, (5) mission/flight flexibility and modularity/commonality, (6) study plan, and (7) description of following tasks: requirement analysis and definition task flow, systems analysis and trade studies, subsystem analysis and trade studies, specifications and interface control documents, preliminary design task flow, work breakdown structure, programmatic analysis and planning, and project costs. Finally, an overview of the scientific requirements was presented.

  6. Chronic Fatigue Syndrome – A clinically empirical approach to its definition and study

    Directory of Open Access Journals (Sweden)

    Papanicolaou Dimitris A

    2005-12-01

    Full Text Available Abstract Background The lack of standardized criteria for defining chronic fatigue syndrome (CFS has constrained research. The objective of this study was to apply the 1994 CFS criteria by standardized reproducible criteria. Methods This population-based case control study enrolled 227 adults identified from the population of Wichita with: (1 CFS (n = 58; (2 non-fatigued controls matched to CFS on sex, race, age and body mass index (n = 55; (3 persons with medically unexplained fatigue not CFS, which we term ISF (n = 59; (4 CFS accompanied by melancholic depression (n = 27; and (5 ISF plus melancholic depression (n = 28. Participants were admitted to a hospital for two days and underwent medical history and physical examination, the Diagnostic Interview Schedule, and laboratory testing to identify medical and psychiatric conditions exclusionary for CFS. Illness classification at the time of the clinical study utilized two algorithms: (1 the same criteria as in the surveillance study; (2 a standardized clinically empirical algorithm based on quantitative assessment of the major domains of CFS (impairment, fatigue, and accompanying symptoms. Results One hundred and sixty-four participants had no exclusionary conditions at the time of this study. Clinically empirical classification identified 43 subjects as CFS, 57 as ISF, and 64 as not ill. There was minimal association between the empirical classification and classification by the surveillance criteria. Subjects empirically classified as CFS had significantly worse impairment (evaluated by the SF-36, more severe fatigue (documented by the multidimensional fatigue inventory, more frequent and severe accompanying symptoms than those with ISF, who in turn had significantly worse scores than the not ill; this was not true for classification by the surveillance algorithm. Conclusion The empirical definition includes all aspects of CFS specified in the 1994 case definition and identifies persons with

  7. Exergy destruction and losses on four North Sea offshore platforms: A comparative study of the oil and gas processing plants

    DEFF Research Database (Denmark)

    Voldsund, Mari; Nguyen, Tuong-Van; Elmegaard, Brian

    2014-01-01

    differs across offshore platforms. However, the results indicate that the largest rooms for improvement lie in (i) gas compression systems where large amounts of gas may be compressed and recycled to prevent surge, (ii) production manifolds where well-streams are depressurised and mixed, and (iii......The oil and gas processing plants of four North Sea offshore platforms are analysed and compared, based on the exergy analysis method. Sources of exergy destruction and losses are identified and the findings for the different platforms are compared. Different platforms have different working...... conditions, which implies that some platforms need less heat and power than others. Reservoir properties and composition vary over the lifetime of an oil field, and therefore maintaining a high efficiency of the processing plant is challenging. The results of the analysis show that 27%-57% of the exergy...

  8. The design and implementation of network platform on“ multimedia works designer ”training package

    Institute of Scientific and Technical Information of China (English)

    Wang Hongyi

    2014-01-01

    This article introduces the definition of training package, then elaborates development principles, the basic thought and main technology of the platform, presents a overall designing scheme about the training platform of“multimedia works designer”, andfinally makes a prospect for the development of the platform. We hope this article can be the reference for future designers in training package network platform.

  9. The design and implementation of network platform on“ multimedia works designer ”training package

    Institute of Scientific and Technical Information of China (English)

    Wang; Hongyi

    2014-01-01

    This article introduces the definition of training package, then elaborates development principles, the basic thought and main technology of the platform, presents a overall designing scheme about the training platform of "multimedia works designer", and finally makes a prospect for the development of the platform. We hope this article can be the reference for future designers in training package network platform.

  10. What is a clinical pathway? Refinement of an operational definition to identify clinical pathway studies for a Cochrane systematic review.

    Science.gov (United States)

    Lawal, Adegboyega K; Rotter, Thomas; Kinsman, Leigh; Machotta, Andreas; Ronellenfitsch, Ulrich; Scott, Shannon D; Goodridge, Donna; Plishka, Christopher; Groot, Gary

    2016-02-23

    Clinical pathways (CPWs) are a common component in the quest to improve the quality of health. CPWs are used to reduce variation, improve quality of care, and maximize the outcomes for specific groups of patients. An ongoing challenge is the operationalization of a definition of CPW in healthcare. This may be attributable to both the differences in definition and a lack of conceptualization in the field of clinical pathways. This correspondence article describes a process of refinement of an operational definition for CPW research and proposes an operational definition for the future syntheses of CPWs literature. Following the approach proposed by Kinsman et al. (BMC Medicine 8(1):31, 2010) and Wieland et al. (Alternative Therapies in Health and Medicine 17(2):50, 2011), we used a four-stage process to generate a five criteria checklist for the definition of CPWs. We refined the operational definition, through consensus, merging two of the checklist's criteria, leading to a more inclusive criterion for accommodating CPW studies conducted in various healthcare settings. The following four criteria for CPW operational definition, derived from the refinement process described above, are (1) the intervention was a structured multidisciplinary plan of care; (2) the intervention was used to translate guidelines or evidence into local structures; (3) the intervention detailed the steps in a course of treatment or care in a plan, pathway, algorithm, guideline, protocol or other 'inventory of actions' (i.e. the intervention had time-frames or criteria-based progression); and (4) the intervention aimed to standardize care for a specific population. An intervention meeting all four criteria was considered to be a CPW. The development of operational definitions for complex interventions is a useful approach to appraise and synthesize evidence for policy development and quality improvement.

  11. Social Networking as a Platform for Role-Playing Scientific Case Studies

    Science.gov (United States)

    Geyer, Andrea M.

    2014-01-01

    This work discusses the design and implementation of two online case studies in a face-to-face general chemistry course. The case studies were integrated into the course to emphasize the need for science literacy in general society, to enhance critical thinking, to introduce database searching, and to improve primary literature reading skills. An…

  12. Development of a high performance parallel computing platform and its use in the study of nanostructures: Clusters, sheets and tubes

    Science.gov (United States)

    Gowtham, S.

    Small clusters of gallium oxide, technologically important high temperature ceramic, together with interaction of nucleic acid bases with graphene and small-diameter carbon nanotube are focus of first principles calculations in this work. A high performance parallel computing platform is also developed to perform these calculations at Michigan Tech. First principles calculations are based on density functional theory employing either local density or gradient-corrected approximation together with plane wave and Gaussian basis sets. The bulk Ga2O3 is known to be a very good candidate for fabricating electronic devices that operate at high temperatures. To explore the properties of Ga2O3 at nanoscale, we have performed a systematic theoretical study on the small polyatomic gallium oxide clusters. The calculated results find that all lowest energy isomers of GamO n clusters are dominated by the Ga-O bonds over the metal-metal or the oxygen-oxygen bonds. Analysis of atomic charges suggest the clusters to be highly ionic similar to the case of bulk Ga2O3. In the study of sequential oxidation of these clusters starting from Ga3O, it is found that the most stable isomers display up to four different backbones of constituent atoms. Furthermore, the predicted configuration of the ground state of Ga2O is recently confirmed by the experimental results of Neumark's group. Guided by the results of calculations the study of gallium oxide clusters, performance related challenge of computational simulations, of producing high performance computers/platforms, has been addressed. Several engineering aspects were thoroughly studied during the design, development and implementation of the high performance parallel computing platform, RAMA, at Michigan Tech. In an attempt to stay true to the principles of Beowulf revolution, the RAMA cluster was extensively customized to make it easy to understand, and use - for administrators as well as end-users. Following the results of benchmark

  13. Different patient case mix by applying the 2003 SCCM/ESICM/ACCP/ATS/SIS sepsis definitions instead of the 1992 ACCP/SCCM sepsis definitions in surgical patients: a retrospective observational study

    Directory of Open Access Journals (Sweden)

    Kron Martina

    2009-05-01

    Full Text Available Abstract Background Revised consensus sepsis definitions have been published in 2003. The present study was performed to compare the prevalence of different stages of sepsis and ICU mortality rates and find out the case mix within the same collective of postoperative/posttraumatic patients applying either the original 1992 ACCP/SCCM or the revised 2003 SCCM/ESICM/ACCP/ATS/SIS sepsis definitions. Methods Retrospective observational single-centre study in surgical critically ill patients admitted to an University adult ICU. From 01/2007 to 12/2007, 742 patients were surveyed daily computer-assisted with respect to different stages of sepsis. Results Within the same patient collective, applying the 2003 definitions instead of the 1992 definitions, prevalence of severe sepsis (61 vs. 56 and septic shock (205 vs. 162 was higher (p Conclusion The prevalence and mortality rates of various sepsis severity stages differ if defined by the 1992 or the 2003 definitions. Thus, transferring conclusions drawn from data sets regarding severity of sepsis generated with the 1992 definitions to the same population applying the 2003 definitions may be misleading. The 1992 definitions may under-classify patients with severe sepsis.

  14. SINGULARITY ANALYSIS AND COMPARITIVE STUDY OF SIX DEGREE OF FREEDOM STEWART PLATFORM AS A ROBOTIC ARM BY HEURISTIC ALGORITHMS AND SIMULATED ANNEALING

    Directory of Open Access Journals (Sweden)

    ASHWIN MISHRA,

    2011-01-01

    Full Text Available In this study singularity analysis of the six degree of freedom (DOF Stewart Platform using the various heuristic methods in a specified design configuration has been carried out .The Jacobian matrix of the Stewart platform is obtained and the absolute value of the determinant of the Jacobian is taken as the objective function, and the least value of this objective function is fished in the reachable workspace of the Stewart platform so as to find the singular configurations. The singular configurations of the platform depend on the value of this objective function under consideration, if it is zero the configuration is singular. The results thus obtained by different methods namely the genetic algorithm, Particle Swarm optimization and variants and simulated annealing are compared with each other. The variable sets considered are the respective desirable platform motions in the form of translation and rotation in six degrees of freedom. This paper hence presents a proper comparative study of these algorithms based on the results that are obtained and highlights the advantage of each in terms of computational cost and accuracy.

  15. eEduHeart I: A Multicenter, Randomized, Controlled Trial Investigating the Effectiveness of a Cardiac Web-Based eLearning Platform - Rationale and Study Design.

    Science.gov (United States)

    Frederix, Ines; Vandenberk, Thijs; Janssen, Leen; Geurden, Anne; Vandervoort, Pieter; Dendale, Paul

    2017-01-01

    Cardiac telerehabilitation includes, in its most comprehensive format, telemonitoring, telecoaching, social interaction, and eLearning. The specific role of eLearning, however, was seldom assessed. The aim of eEduHeart I is to investigate the medium-term effectiveness of the addition of a cardiac web-based eLearing platform to conventional cardiac care. In this prospective, multicenter randomized, controlled trial, 1,000 patients with coronary artery disease will be randomized 1:1 to an intervention group (receiving 1-month unrestricted access to the cardiac eLearning platform in addition to conventional cardiac care) or to conventional cardiac care alone. The primary endpoint is health-related quality of life, assessed by the HeartQoL questionnaire at the 1- and 3-month follow-ups. Secondary endpoints include pathology-specific knowledge and self-reported eLearning platform user experience. Data on the eLearning platform usage will be gathered through web logging during the study period. eEduHeart I will be one of the first studies to report on the added value of eLearning. If the intervention is proven effective, current cardiac telerehabilitation programs can be augmented by including eLearning, too. The platform can then be used as a model for other chronic diseases in which patient education plays a key role. © 2016 S. Karger AG, Basel.

  16. Soil-on-a-Chip: microfluidic platforms for environmental organismal studies.

    Science.gov (United States)

    Stanley, Claire E; Grossmann, Guido; i Solvas, Xavier Casadevall; deMello, Andrew J

    2016-01-21

    Soil is the habitat of countless organisms and encompasses an enormous variety of dynamic environmental conditions. While it is evident that a thorough understanding of how organisms interact with the soil environment may have substantial ecological and economical impact, current laboratory-based methods depend on reductionist approaches that are incapable of simulating natural diversity. The application of Lab-on-a-Chip or microfluidic technologies to organismal studies is an emerging field, where the unique benefits afforded by system miniaturisation offer new opportunities for the experimentalist. Indeed, precise spatiotemporal control over the microenvironments of soil organisms in combination with high-resolution imaging has the potential to provide an unprecedented view of biological events at the single-organism or single-cell level, which in turn opens up new avenues for environmental and organismal studies. Herein we review some of the most recent and interesting developments in microfluidic technologies for the study of soil organisms and their interactions with the environment. We discuss how so-called "Soil-on-a-Chip" technology has already contributed significantly to the study of bacteria, nematodes, fungi and plants, as well as inter-organismal interactions, by advancing experimental access and environmental control. Most crucially, we highlight where distinct advantages over traditional approaches exist and where novel biological insights will ensue.

  17. Integrated microfluidic platform for bilayer studies and experimentation on single pore-forming species

    NARCIS (Netherlands)

    Stimberg, V.C.; Berg, van den A.; Le Gac, S.

    2011-01-01

    The combination of microfluidics with BLMs (bilayer lipid membranes) consists of a powerful tool for multiplexed and high-throughput studies on membrane properties and membrane proteins. Here, we report an integrated device for BLM ex-perimentation using both optical and electrical measurements. Thi

  18. Evaluation of a target region capture sequencing platform using monogenic diabetes as a study-model

    DEFF Research Database (Denmark)

    Gao, R.; Liu, Y. X.; Gjesing, A. P.;

    2014-01-01

    diabetes as a study-model. Results: The performance of the assay was evaluated in 70 patients carrying known disease causing mutations previously identified in HNF4A, GCK, HNF1A, HNF1B, INS, or KCNJ11. Target regions with a less than 20-fold sequencing depth were either introns or UTRs. When only...

  19. Maritime Platform Sleep and Performance Study: Evaluating the SAFTE Model for Maritime Workplace Application

    Science.gov (United States)

    2012-06-01

    Finally, 60% of the participants reported requiring one or more caffeinated beverages a day ( coffee , soda, or energy drink). Figure 16 shows the...stress on cognitive perofrmance and mood during U.S. Navy SEAL training. Sea-Air-Land. Psychopharmacology, 164(3), 250–61. Lumley, M., Roehrs, T...T. D., French, J., & Mitcha, J. L. (1997). A study of USAF air traffic controller shiftwork: sleep, fatigue, activity, and mood analyses. Aviation

  20. Developing Knowledge-Based Citizen Participation Platform to Support Smart City Decision Making: The Smarticipate Case Study

    National Research Council Canada - National Science Library

    Zaheer Khan; Jens Dambruch; Jan Peters-Anders; Andreas Sackl; Anton Strasser; Peter Fröhlich; Simon Templer; Kamran Soomro

    2017-01-01

    .... Using such a system as a communication platform between citizens and city administrations provides an integrated top-down and bottom-up urban planning and decision-making approach to smart cities...

  1. Aquatic flower-inspired cell culture platform with simplified medium exchange process for facilitating cell-surface interaction studies.

    Science.gov (United States)

    Hong, Hyeonjun; Park, Sung Jea; Han, Seon Jin; Lim, Jiwon; Kim, Dong Sung

    2016-02-01

    Establishing fundamentals for regulating cell behavior with engineered physical environments, such as topography and stiffness, requires a large number of cell culture experiments. However, cell culture experiments in cell-surface interaction studies are generally labor-intensive and time-consuming due to many experimental tasks, such as multiple fabrication processes in sample preparation and repetitive medium exchange in cell culture. In this work, a novel aquatic flower-inspired cell culture platform (AFIP) is presented. AFIP aims to facilitate the experiments on the cell-surface interaction studies, especially the medium exchange process. AFIP was devised to capture and dispense cell culture medium based on interactions between an elastic polymer substrate and a liquid medium. Thus, the medium exchange can be performed easily and without the need of other instruments, such as a vacuum suction and pipette. An appropriate design window of AFIP, based on scaling analysis, was identified to provide a criterion for achieving stability in medium exchange as well as various surface characteristics of the petal substrates. The developed AFIP, with physically engineered petal substrates, was also verified to exchange medium reliably and repeatedly. A closed structure capturing the medium was sustained stably during cell culture experiments. NIH3T3 proliferation results also demonstrated that AFIP can be applied to the cell-surface interaction studies as an alternative to the conventional method.

  2. Marginal bone and soft tissue behavior following platform switching abutment connection/disconnection--a dog model study.

    Science.gov (United States)

    Alves, Célia C; Muñoz, Fernando; Cantalapiedra, António; Ramos, Isabel; Neves, Manuel; Blanco, Juan

    2015-09-01

    The effect on the marginal peri-implant tissues following repeated platform switching abutment removal and subsequent reconnection was studied. Six adult female Beagle dogs were selected, and Pm3 and Pm4 teeth, both left and right sides, were extracted and the sites healed for 3 months. At this time, 24 bone level (BL) (Straumann, Basel, Switzerland) Ø 3.3/8 mm implants were placed, 2 in each side on Pm3 and Pm4 regions. In one side (control group), 12 bone level conical Ø 3.6 mm healing abutments and, on the other side (test group), 12 Narrow CrossFit (NC) multibase abutments (Straumann) , Basel, Switzerland) were connected at time of implant surgery. On test group, all prosthetic procedures were carried out direct to multibase abutment without disconnecting it, where in the control group, the multibase abutment was connected/disconnected five times (at 6/8/10/12/14 weeks) during prosthetic procedures. Twelve fixed metal bridges were delivered 14 weeks after implant placement. A cleaning/control appointment was scheduled 6 months after implant placement. The animals were sacrificed at 9 months of the study. Clinical parameters and peri-apical x-rays were registered in every visit. Histomorphometric analysis was carried out for the 24 implants. The distance from multibase abutment shoulder to the first bone implant contact (S-BIC) was defined as the primary histomorphometric parameter. Wilcoxon comparison paired test (n = 6) found no statistically significant differences (buccal P = 0.917; Lingual P = 0.463) between test and control groups both lingually and buccally for S-BIC distance. Only Pm3 buccal aBE-BC (distance from the apical end of the barrier epithelium to the first bone implant contact) (P = 0.046) parameter presented statistically significant differences between test and control groups. Control group presented 0.57 mm more recession than test group, being this difference statistically significant between the two groups (P < 0.001). It can be conclude

  3. A case study for integrated STEM outreach in an urban setting using a do-it-yourself vertical jump measurement platform.

    Science.gov (United States)

    Drazan, John F; Danielsen, Heather; Vercelletto, Matthew; Loya, Amy; Davis, James; Eglash, Ron

    2016-08-01

    The purpose of this study was to develop and deploy a low cost vertical jump platform using readily available materials for Science, Technology, Engineering, and Mathematics (STEM) education and outreach in the inner city. The platform was used to measure the jumping ability of participants to introduce students to the collection and analysis of scientific data in an engaging, accessible manner. This system was designed and fabricated by a student team of engineers as part of a socially informed engineering and design class. The vertical jump platform has been utilized in 10 classroom lectures in physics and biology. The system was also used in an after school program in which high school volunteers prepared a basketball based STEM outreach program, and at a community outreach events with over 100 participants. At present, the same group of high school students are now building their own set of vertical jump platform under the mentorship of engineering undergraduates. The construction and usage of the vertical jump platform provides an accessible introduction to the STEM fields within the urban community.

  4. Accelerating translational research by clinically driven development of an informatics platform--a case study.

    Directory of Open Access Journals (Sweden)

    Imad Abugessaisa

    Full Text Available Translational medicine is becoming increasingly dependent upon data generated from health care, clinical research, and molecular investigations. This increasing rate of production and diversity in data has brought about several challenges, including the need to integrate fragmented databases, enable secondary use of patient clinical data from health care in clinical research, and to create information systems that clinicians and biomedical researchers can readily use. Our case study effectively integrates requirements from the clinical and biomedical researcher perspectives in a translational medicine setting. Our three principal achievements are (a a design of a user-friendly web-based system for management and integration of clinical and molecular databases, while adhering to proper de-identification and security measures; (b providing a real-world test of the system functionalities using clinical cohorts; and (c system integration with a clinical decision support system to demonstrate system interoperability. We engaged two active clinical cohorts, 747 psoriasis patients and 2001 rheumatoid arthritis patients, to demonstrate efficient query possibilities across the data sources, enable cohort stratification, extract variation in antibody patterns, study biomarker predictors of treatment response in RA patients, and to explore metabolic profiles of psoriasis patients. Finally, we demonstrated system interoperability by enabling integration with an established clinical decision support system in health care. To assure the usefulness and usability of the system, we followed two approaches. First, we created a graphical user interface supporting all user interactions. Secondly we carried out a system performance evaluation study where we measured the average response time in seconds for active users, http errors, and kilobits per second received and sent. The maximum response time was found to be 0.12 seconds; no server or client errors of any

  5. Accelerating translational research by clinically driven development of an informatics platform--a case study.

    Science.gov (United States)

    Abugessaisa, Imad; Saevarsdottir, Saedis; Tsipras, Giorgos; Lindblad, Staffan; Sandin, Charlotta; Nikamo, Pernilla; Ståhle, Mona; Malmström, Vivianne; Klareskog, Lars; Tegnér, Jesper

    2014-01-01

    Translational medicine is becoming increasingly dependent upon data generated from health care, clinical research, and molecular investigations. This increasing rate of production and diversity in data has brought about several challenges, including the need to integrate fragmented databases, enable secondary use of patient clinical data from health care in clinical research, and to create information systems that clinicians and biomedical researchers can readily use. Our case study effectively integrates requirements from the clinical and biomedical researcher perspectives in a translational medicine setting. Our three principal achievements are (a) a design of a user-friendly web-based system for management and integration of clinical and molecular databases, while adhering to proper de-identification and security measures; (b) providing a real-world test of the system functionalities using clinical cohorts; and (c) system integration with a clinical decision support system to demonstrate system interoperability. We engaged two active clinical cohorts, 747 psoriasis patients and 2001 rheumatoid arthritis patients, to demonstrate efficient query possibilities across the data sources, enable cohort stratification, extract variation in antibody patterns, study biomarker predictors of treatment response in RA patients, and to explore metabolic profiles of psoriasis patients. Finally, we demonstrated system interoperability by enabling integration with an established clinical decision support system in health care. To assure the usefulness and usability of the system, we followed two approaches. First, we created a graphical user interface supporting all user interactions. Secondly we carried out a system performance evaluation study where we measured the average response time in seconds for active users, http errors, and kilobits per second received and sent. The maximum response time was found to be 0.12 seconds; no server or client errors of any kind were detected

  6. The Southern Argentina Agile Meteor Radar (SAAMER): Platform for comprehensive meteor radar observations and studies

    Science.gov (United States)

    Janches, D.; Hormaechea, J.; Pifko, S.; Hocking, W.; Fritts, D.; Brunini, C.; Close, S.; Michell, R.; Samara, M.

    2014-07-01

    The Southern Argentina Agile Meteor Radar (SAAMER) is a new generation system deployed in Rio Grande, Tierra del Fuego, Argentina (53^oS) in May 2008 (Janches et al., 2013,2014). SAAMER transmits 10 times more power than regular meteor radars, and uses a newly developed transmitting array, which focuses power upward instead of the traditional single-antenna-all-sky configuration. The system is configured such that the transmitter array can also be utilized as a receiver. The new design greatly increases the sensitivity of the radar enabling the detection of large numbers of particles at low zenith angles. The more concentrated transmitted power enables additional meteor studies besides those typical of these systems based on the detection of specular reflections, such as routine detections of head echoes and non-specular trails, previously only possible with High Power and Large Aperture radars (Janches et al., 2014). In August 2010, SAAMER was upgraded to a system capable to determine meteoroid orbital parameters. This was achieved by adding two remote receiving stations approximately 10 km away from the main site in near perpendicular directions (Pifko et al., 2014). The upgrade significantly expands the science that is achieved with this new radar enabling us to study the orbital properties of the interplanetary dust environment. Because of the unique geographical location, the SAAMER allows for additional inter-hemispheric comparison with measurements from Canadian Meteor Orbit Radar, which is geographically conjugate. Initial surveys show, for example, that SAAMER observes a very strong contribution of the South Toroidal Sporadic meteor source (Pifko et al., 2014), of which limited observational data is available. In addition, SAAMER offers similar unique capabilities for meteor showers and streams studies given the range of ecliptic latitudes that the system enables to survey (Janches et al., 2013). It can effectively observe radiants from the ecliptic south

  7. Investigating the vertical dimension of Singapore's urban heat island through quadcopter platforms: an pilot study

    Science.gov (United States)

    Chow, Winston; Ho, Dawn

    2016-04-01

    In numerous cities, measurements of urban warmth in most urban heat island (UHI) studies are generally constrained towards surface or near-surface (Singapore, which is a rapidly urbanizing major tropical metropolis. Three different land use/land cover categories were sampled; a high-rise residential estate, a university campus, and an urban park/green-space. Sorties were flown repeatedly at four different times - sunrise, noon, sunset and midnight. Initial results indicate significant variations in intra-site stability and inversion development between the urban canopy and boundary layers. These profiles are also temporally dynamic, depending on the time of day and larger-scale weather conditions.

  8. Evaluation of a target region capture sequencing platform using monogenic diabetes as a study-model

    DEFF Research Database (Denmark)

    Gao, R.; Liu, Y. X.; Gjesing, A. P.;

    2014-01-01

    Background: Monogenic diabetes is a genetic disease often caused by mutations in genes involved in beta-cell function. Correct sub-categorization of the disease is a prerequisite for appropriate treatment and genetic counseling. Target-region capture sequencing is a combination of genomic region...... diabetes as a study-model. Results: The performance of the assay was evaluated in 70 patients carrying known disease causing mutations previously identified in HNF4A, GCK, HNF1A, HNF1B, INS, or KCNJ11. Target regions with a less than 20-fold sequencing depth were either introns or UTRs. When only...... of monogenic diabetes....

  9. A comparative study of submicron particle sizing platforms: accuracy, precision and resolution analysis of polydisperse particle size distributions.

    Science.gov (United States)

    Anderson, Will; Kozak, Darby; Coleman, Victoria A; Jämting, Åsa K; Trau, Matt

    2013-09-01

    The particle size distribution (PSD) of a polydisperse or multimodal system can often be difficult to obtain due to the inherent limitations in established measurement techniques. For this reason, the resolution, accuracy and precision of three new and one established, commercially available and fundamentally different particle size analysis platforms were compared by measuring both individual and a mixed sample of monodisperse, sub-micron (220, 330, and 410 nm - nominal modal size) polystyrene particles. The platforms compared were the qNano Tunable Resistive Pulse Sensor, Nanosight LM10 Particle Tracking Analysis System, the CPS Instruments's UHR24000 Disc Centrifuge, and the routinely used Malvern Zetasizer Nano ZS Dynamic Light Scattering system. All measurements were subjected to a peak detection algorithm so that the detected particle populations could be compared to 'reference' Transmission Electron Microscope measurements of the individual particle samples. Only the Tunable Resistive Pulse Sensor and Disc Centrifuge platforms provided the resolution required to resolve all three particle populations present in the mixed 'multimodal' particle sample. In contrast, the light scattering based Particle Tracking Analysis and Dynamic Light Scattering platforms were only able to detect a single population of particles corresponding to either the largest (410 nm) or smallest (220 nm) particles in the multimodal sample, respectively. When the particle sets were measured separately (monomodal) each platform was able to resolve and accurately obtain a mean particle size within 10% of the Transmission Electron Microscope reference values. However, the broadness of the PSD measured in the monomodal samples deviated greatly, with coefficients of variation being ~2-6-fold larger than the TEM measurements across all four platforms. The large variation in the PSDs obtained from these four, fundamentally different platforms, indicates that great care must still be taken in

  10. Wearable wireless sensor platform for studying autonomic activity and social behavior in non-human primates.

    Science.gov (United States)

    Fletcher, Richard Ribón; Amemori, Ken-ichi; Goodwin, Matthew; Graybiel, Ann M

    2012-01-01

    A portable system has been designed to enable remote monitoring of autonomic nervous system output in non-human primates for the purpose of studying neural function related to social behavior over extended periods of time in an ambulatory setting. In contrast to prior systems which only measure heart activity, are restricted to a constrained laboratory setting, or require surgical attachment, our system is comprised of a multi-sensor self-contained wearable vest that can easily be transferred from one subject to another. The vest contains a small detachable low-power electronic sensor module for measuring electrodermal activity (EDA), electrocardiography (ECG), 3-axis acceleration, and temperature. The wireless transmission is implemented using a standard Bluetooth protocol and a mobile phone, which enables freedom of movement for the researcher as well as for the test subject. A custom Android software application was created on the mobile phone for viewing and recording live data as well as creating annotations. Data from up to seven monkeys can be recorded simultaneously using the mobile phone, with the option of real-time upload to a remote web server. Sample data are presented from two rhesus macaque monkeys showing stimulus-induced response in the laboratory as well as long-term ambulatory data collected in a large monkey cage. This system enables new possibilities for studying underlying mechanisms between autonomic brain function and social behavior with connection to human research in areas such as autism, substance abuse, and mood disorders.

  11. An Interoperability Platform Enabling Reuse of Electronic Health Records for Signal Verification Studies

    Science.gov (United States)

    Yuksel, Mustafa; Gonul, Suat; Laleci Erturkmen, Gokce Banu; Sinaci, Ali Anil; Invernizzi, Paolo; Facchinetti, Sara; Migliavacca, Andrea; Bergvall, Tomas; Depraetere, Kristof; De Roo, Jos

    2016-01-01

    Depending mostly on voluntarily sent spontaneous reports, pharmacovigilance studies are hampered by low quantity and quality of patient data. Our objective is to improve postmarket safety studies by enabling safety analysts to seamlessly access a wide range of EHR sources for collecting deidentified medical data sets of selected patient populations and tracing the reported incidents back to original EHRs. We have developed an ontological framework where EHR sources and target clinical research systems can continue using their own local data models, interfaces, and terminology systems, while structural interoperability and Semantic Interoperability are handled through rule-based reasoning on formal representations of different models and terminology systems maintained in the SALUS Semantic Resource Set. SALUS Common Information Model at the core of this set acts as the common mediator. We demonstrate the capabilities of our framework through one of the SALUS safety analysis tools, namely, the Case Series Characterization Tool, which have been deployed on top of regional EHR Data Warehouse of the Lombardy Region containing about 1 billion records from 16 million patients and validated by several pharmacovigilance researchers with real-life cases. The results confirm significant improvements in signal detection and evaluation compared to traditional methods with the missing background information. PMID:27123451

  12. An Interoperability Platform Enabling Reuse of Electronic Health Records for Signal Verification Studies

    Directory of Open Access Journals (Sweden)

    Mustafa Yuksel

    2016-01-01

    Full Text Available Depending mostly on voluntarily sent spontaneous reports, pharmacovigilance studies are hampered by low quantity and quality of patient data. Our objective is to improve postmarket safety studies by enabling safety analysts to seamlessly access a wide range of EHR sources for collecting deidentified medical data sets of selected patient populations and tracing the reported incidents back to original EHRs. We have developed an ontological framework where EHR sources and target clinical research systems can continue using their own local data models, interfaces, and terminology systems, while structural interoperability and Semantic Interoperability are handled through rule-based reasoning on formal representations of different models and terminology systems maintained in the SALUS Semantic Resource Set. SALUS Common Information Model at the core of this set acts as the common mediator. We demonstrate the capabilities of our framework through one of the SALUS safety analysis tools, namely, the Case Series Characterization Tool, which have been deployed on top of regional EHR Data Warehouse of the Lombardy Region containing about 1 billion records from 16 million patients and validated by several pharmacovigilance researchers with real-life cases. The results confirm significant improvements in signal detection and evaluation compared to traditional methods with the missing background information.

  13. Carbon Nanotube-Based Permeable Membranes: A Platform for Studying Nanofluidics

    Energy Technology Data Exchange (ETDEWEB)

    Holt, J K; Park, H G; Noy, A; Huser, T; Eaglesham, D; Bakajin, O

    2004-05-25

    A membrane of multiwalled carbon nanotubes embedded in a silicon nitride matrix was fabricated for use in studying fluid mechanics on the nanometer scale. Characterization by fluorescent tracer diffusion and scanning electron microscopy suggests that the membrane is void-free near the silicon substrate on which it rests, implying that the hollow core of the nanotube is the only conduction path for molecular transport. Nitrogen flow measurements of a nanoporous silicon nitride membrane, fabricated by sacrificial removal of carbon, give a flow rate of 0.086 cc/sec. Calculations of water flow across a nanotube membrane give a rate of 2.1x10{sup -6} cc/sec (0.12 {micro}L/min).

  14. Note: Experimental platform for magnetized high-energy-density plasma studies at the omega laser facility.

    Science.gov (United States)

    Fiksel, G; Agliata, A; Barnak, D; Brent, G; Chang, P-Y; Folnsbee, L; Gates, G; Hasset, D; Lonobile, D; Magoon, J; Mastrosimone, D; Shoup, M J; Betti, R

    2015-01-01

    An upgrade of the pulsed magnetic field generator magneto-inertial fusion electrical discharge system [O. Gotchev et al., Rev. Sci. Instrum. 80, 043504 (2009)] is described. The device is used to study magnetized high-energy-density plasma and is capable of producing a pulsed magnetic field of tens of tesla in a volume of a few cubic centimeters. The magnetic field is created by discharging a high-voltage capacitor through a small wire-wound coil. The coil current pulse has a duration of about 1 μs and a peak value of 40 kA. Compared to the original, the updated version has a larger energy storage and improved switching system. In addition, magnetic coils are fabricated using 3-D printing technology which allows for a greater variety of the magnetic field topology.

  15. Note: Experimental platform for magnetized high-energy-density plasma studies at the omega laser facility

    Science.gov (United States)

    Fiksel, G.; Agliata, A.; Barnak, D.; Brent, G.; Chang, P.-Y.; Folnsbee, L.; Gates, G.; Hasset, D.; Lonobile, D.; Magoon, J.; Mastrosimone, D.; Shoup, M. J.; Betti, R.

    2015-01-01

    An upgrade of the pulsed magnetic field generator magneto-inertial fusion electrical discharge system [O. Gotchev et al., Rev. Sci. Instrum. 80, 043504 (2009)] is described. The device is used to study magnetized high-energy-density plasma and is capable of producing a pulsed magnetic field of tens of tesla in a volume of a few cubic centimeters. The magnetic field is created by discharging a high-voltage capacitor through a small wire-wound coil. The coil current pulse has a duration of about 1 μs and a peak value of 40 kA. Compared to the original, the updated version has a larger energy storage and improved switching system. In addition, magnetic coils are fabricated using 3-D printing technology which allows for a greater variety of the magnetic field topology.

  16. The Virtual Mouse Brain: A Computational Neuroinformatics Platform to Study Whole Mouse Brain Dynamics.

    Science.gov (United States)

    Melozzi, Francesca; Woodman, Marmaduke M; Jirsa, Viktor K; Bernard, Christophe

    2017-01-01

    Connectome-based modeling of large-scale brain network dynamics enables causal in silico interrogation of the brain's structure-function relationship, necessitating the close integration of diverse neuroinformatics fields. Here we extend the open-source simulation software The Virtual Brain (TVB) to whole mouse brain network modeling based on individual diffusion magnetic resonance imaging (dMRI)-based or tracer-based detailed mouse connectomes. We provide practical examples on how to use The Virtual Mouse Brain (TVMB) to simulate brain activity, such as seizure propagation and the switching behavior of the resting state dynamics in health and disease. TVMB enables theoretically driven experimental planning and ways to test predictions in the numerous strains of mice available to study brain function in normal and pathological conditions.

  17. The Bodymind Model: A platform for studying the mechanisms of change induced by art therapy.

    Science.gov (United States)

    Czamanski-Cohen, J; Weihs, K L

    2016-09-01

    This paper introduces the Bodymind model of Art Therapy and delineates the processes through which it has salutary effects on individuals coping with a variety of health related challenges. The goal of this model is to articulate how activation, reorganization, growth and reintegration of the self can emerge from bodymind processes activated by art therapy. It provides a framework for the conduct of research that will test the key theoretical mechanisms through which art therapy benefits clients. We expect this model to be a spring board for discussion, debate and development of the profession of art therapy. Furthermore, we hope readers can use this model to conduct sound mechanistic studies. This paper can inform social scientists and medical professionals on the manner in which art making can contribute to health.

  18. Diabetic Foot Prevention: Repeatability of the Loran Platform Plantar Pressure and Load Distribution Measurements in Nondiabetic Subjects during Bipedal Standing—A Pilot Study

    Directory of Open Access Journals (Sweden)

    Martha Zequera

    2011-01-01

    Full Text Available This study was designed to assess the repeatability of the Loran Platform and evaluate the variability of plantar pressure and postural balance, during barefoot standing in nondiabetic subjects, for future diabetic foot clinical evaluation. Measurements were taken for eight nondiabetic subjects (4 females, 4 males, aged 47±7.2 years who had no musculoskeletal symptoms. Five variables were measured with the platform in the barefoot standing position. Ten measurements were taken using two different techniques for feet and posture positioning, during three sessions, once a week. For most measurements, no significant effect over time was found with Student's t-test (P<.000125. The ANOVA test of statistical significance confirmed that measurement differences between subjects showed higher variations than measurements taken from the same subject (P<.001. The measurements taken by the Loran Platform system were found to be repeatable.

  19. BIOREGIS software platform based on GIS technology to support in-situ remediation of petroleum contaminated sites. Case study: razvad - dambovita county, Romania

    Energy Technology Data Exchange (ETDEWEB)

    Anicai, Ovidiu [Institute for Computers - ITC SA, Bucharest (Romania); Anicai, Liana [PSV COMPANY SA, Direction of Research, Bucharest (Romania)

    2011-12-15

    With a need for the management of petroleum contaminated sites on Romanian territory, an experimental software platform involving ESRI-ArcGIS technologies (BIOREGIS) is presented in this study. The BIOREGIS platform is aimed to: (i) Build the structure of relational, standardized databases to store spatial and textual characteristic information on polluted sites for further risk analysis and planning of remediation actions, (ii) improve the pollution risk assessment methodology for Romanian petroleum contaminated sites and its informatics implementation, and (iii) develop and operate the software platform for pollution risk based management involving GIS/remote sensing technologies and remediation activities. The operation of BIOREGIS has been tested for a pilot contaminated area situated at Razvad - Dambovita County, which has been subjected to in situ remediation procedures involving both bioremediation and electrokinetic processes. (Copyright copyright 2011 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  20. 基于BIRIS的海运物流服务平台案例研究%A Case Study on BIRIS-Based Marine Logistics Service Platform

    Institute of Scientific and Technical Information of China (English)

    马超; 王忠杰; 徐晓飞

    2009-01-01

    With increasing competition in international marine logistics service industry.the voice of improving marine logistics service for reducing operation cost and improving service quality is much higher.Aiming at the marine logistics services between Weihai and Korea,this paper makes a case study to design a BIRIS-based public platform for this service.Firstly,current business scenarios of Sino-Korea marine logistics services are briefly analyzed and some business issues that need to be solved urgently ale listed,e.g.,lack of effective communication channel between cargo owners and various service providers,low coordination efficiency between different service providers etc.Aiming at these problems,a BIRIS based marine logistics service platform is designed.TO-BE business scenario,SOA techniques for developing such platform,and some examples of identifying services,designing service interfaces and designing portal for each service provider,are elaborately shown.

  1. Liquid PEG Polymers Containing Antioxidants: A Versatile Platform for Studying Oxygen-Sensitive Photochemical Processes.

    Science.gov (United States)

    Mongin, Cédric; Golden, Jessica H; Castellano, Felix N

    2016-09-14

    This article proposes the exploitation of widely available, inexpensive, innocuous "green" liquid polyethylene glycol (PEG) polymers containing the oxygen scavenger oleic acid (OA) as promising media for studying oxygen-sensitive photochemical processes. Here we report the successful application of this media to detailed investigations of triplet-sensitized photochemical upconversion, previously established as being readily poisoned by dissolved oxygen. Three different PEG materials were investigated with increasing molecular weight from 200 to 600 g/mol, coded as PEG-200, PEG-400, and PEG-600. These fluidic polymers facilitate an oxygen-depleted environment in comparison to commonly employed organic solvents while providing high solubility and diffusion for the dissolved chromophores. Moreover, the low oxygen permeation afforded by these PEG solvents allows them to remain deoxygenated in open containers under ambient conditions for extended time periods. OA, 9,10-dimethylanthracene (DMA), and 2,5-dimethylfuran (DMF) are shown to efficiently and quantitatively consume dissolved oxygen in the PEG environment in the presence of the photoactivated triplet sensitizer platinum(II) tetraphenyltetrabenzoporphyrin (PtTPBP). Oxygen consumption was directly correlated with systematically increasing sensitizer excited-state lifetimes that eventually reach the same plateau as achieved through extensive N2 sparging. Diffusion-controlled bimolecular triplet-triplet energy transfer quenching between PtTPBP and the acceptor/annihilator 9,10-bisphenylethynylanthracene (BPEA) was observed in all three PEG formulations investigated. Subsequent triplet-triplet annihilation, between triplet excited BPEA acceptors, achieves bright and stable upconverted singlet fluorescence from BPEA with no decrease in intensity over 20 h under ambient conditions. In the champion composition (PEG 200), the upconversion quantum efficiency reached 31% under conditions where triplet-triplet annihilation

  2. Expanding the study of internet gambling behavior: trends within the Icelandic lottery and sportsbetting platform.

    Science.gov (United States)

    Gray, Heather M; Jónsson, Guðberg K; LaPlante, Debi A; Shaffer, Howard J

    2015-06-01

    As rates of Internet gambling participation increase worldwide, so too does the need to understand how people engage in this form of gambling. This study represents the first examination of actual Internet gambling records within Iceland, a Nordic country with an active Internet lottery market that imposes strict regulations on gambling operator licenses. We summarized electronic betting records of a cohort of subscribers to the Internet betting service provider Íslensk Getspá. We observed that the typical subscriber bet approximately 3 days per month and made fewer than two bets per gambling day, each worth approximately the equivalent of $4 US. Subscribers lost the bulk (96%) of the amount they wagered, for a total loss of approximately $40 across the 2-year window of observation. Although these observations do not support the view of Internet gambling as an activity that is inherently risky for the typical subscriber, we did observe discontinuity across the distributions of gambling behavior, with the top 1% of subscribers making more than three bets per day.

  3. Product Platform Screening at LEGO

    DEFF Research Database (Denmark)

    Mortensen, Niels Henrik; Steen Jensen, Thomas; Nielsen, Ole Fiil

    2012-01-01

    Product platforms offer great benefits to companies developing new products in highly competitive markets. Literature describes how a single platform can be designed from a technical point of view, but rarely mentions how the process begins. How do companies identify possible platform candidates......, and how do they assess if these candidates have enough potential to be worth implementing? Danish toy manufacturer LEGO has systematically gone through this process twice. The first time the results were poor; almost all platform candidates failed. The second time, though, has been largely successful...... after a few changes had been applied to the initial process layout. This case study shows how companies must focus on a limited selection of simultaneous projects in order to keep focus. Primary stakeholders must be involved from the very beginning, and short presentations of the platform concepts...

  4. A draft genome of the brown alga, Cladosiphon okamuranus, S-strain: a platform for future studies of 'mozuku' biology.

    Science.gov (United States)

    Nishitsuji, Koki; Arimoto, Asuka; Iwai, Kenji; Sudo, Yusuke; Hisata, Kanako; Fujie, Manabu; Arakaki, Nana; Kushiro, Tetsuo; Konishi, Teruko; Shinzato, Chuya; Satoh, Noriyuki; Shoguchi, Eiichi

    2016-12-01

    The brown alga, Cladosiphon okamuranus (Okinawa mozuku), is economically one of the most important edible seaweeds, and is cultivated for market primarily in Okinawa, Japan. C. okamuranus constitutes a significant source of fucoidan, which has various physiological and biological activities. To facilitate studies of seaweed biology, we decoded the draft genome of C. okamuranus S-strain. The genome size of C. okamuranus was estimated as ∼140 Mbp, smaller than genomes of two other brown algae, Ectocarpus siliculosus and Saccharina japonica Sequencing with ∼100× coverage yielded an assembly of 541 scaffolds with N50 = 416 kbp. Together with transcriptomic data, we estimated that the C. okamuranus genome contains 13,640 protein-coding genes, approximately 94% of which have been confirmed with corresponding mRNAs. Comparisons with the E. siliculosus genome identified a set of C. okamuranus genes that encode enzymes involved in biosynthetic pathways for sulfated fucans and alginate biosynthesis. In addition, we identified C. okamuranus genes for enzymes involved in phlorotannin biosynthesis. The present decoding of the Cladosiphon okamuranus genome provides a platform for future studies of mozuku biology. © The Author 2016. Published by Oxford University Press on behalf of Kazusa DNA Research Institute.

  5. Self-assembled molecular platforms for bacteria/material biointerface studies: importance to control functional group accessibility.

    Science.gov (United States)

    Böhmler, Judith; Ponche, Arnaud; Anselme, Karine; Ploux, Lydie

    2013-11-13

    Highly controlled mixed molecular layers are crucial to study the role of material surface chemistry in biointerfaces, such as bacteria and subsequent biofilms interacting with biomaterials. Silanes with non-nucleophilic functional groups are promising to form self-assembled monolayers (SAMs) due to their low sensitivity to side-reactions. Nevertheless, the real control of surface chemistry, layer structure, and organization has not been determined. Here, we report a comprehensive synthesis and analysis of undecyltrichlorosilane- and 11-bromoundecyltrichlorosilane-based mixed SAMs on silicon substrates. The impact of the experimental conditions on the control of surface chemistry, layer structure, and organization was investigated by combining survey and high-resolution X-ray photoelectron spectroscopy analysis, wettability measurements, and ellipsometry. The most appropriate conditions were first determined for elaborating highly reproducible, but easily made, pure 11-bromoundecyltrichlorosilane SAMs. We have demonstrated that the control is maintained on more complex surfaces, i.e., surfaces revealing various chemical densities, which were obtained with different ratios of undecyltrichlorosilane and 11-bromoundecyltrichlorosilane. The control is also maintained after bromine to amine group conversion via SN2 bromine-to-azide reactions. The appropriateness of such highly controlled amino- and methyl-group revealing platforms (NH2-X%/CH3) for biointerface studies was shown by the higher reproducibility of bacterial adhesion on NH2-100%/CH3 SAMs compared to bacterial adhesion on molecular layers of overall similar surface chemistry but less control at the molecular scale.

  6. Student involvement as a vehicle for empowerment: a case study of the student platform for engineering education development

    KAUST Repository

    Delaine, David A.

    2010-08-01

    This paper examines the mission, structure and outputs of one organisation, the Student Platform for Engineering Education Development (SPEED), as a case study for how student-led organisations can use student involvement to promote and sustain student self-efficacy in an academic field. SPEED attracts young people to engineering through student participation in engineering education (EE). SPEED is a global, non-profit student organisation that functions as an interdisciplinary network to diversify dialogue, stimulate change and impact the development of EE and its effect on society. SPEED is directly attracting young people to engineering in various ways: the organisation of its keynote event, the Global Student Forum; facilitating interactions between globally minded, socially inclined engineers with aspirations to change the world; and through the global dissemination of SPEED\\'s work and practices through broad and relevant channels. Short-term outcomes are highlighted here. This case study can serve as a model for student engagement and involvement in other disciplines. © 2010 SEFI.

  7. An exploratory study using a statistical approach as a platform for clinical reasoning in canine epilepsy.

    Science.gov (United States)

    Armaşu, M; Packer, R M A; Cook, S; Solcan, G; Volk, H A

    2014-11-01

    Links between deficits identified on neurological examination, age of seizure onset and the presence of structural forebrain disease have often been postulated in dogs presenting with a history of seizures. The purpose of this study was to assess the influence of such factors on the likelihood of structural or functional brain disease, via a thorough history taking process and interictal neurological examination. Four hundred and four dogs with seizures due to intracranial causes were included. Data including age, sex, neuter status, time until diagnosis, age of seizure onset in years, type of seizure, seizure symmetry, seizure severity, interictal neurological deficits, MRI changes and side effects associated with antiepileptic drugs were extracted from medical files. Two hundred and fifty-eight dogs were diagnosed with epilepsy of unknown origin (EUO), 11 with symmetrical structural lesions and 135 with asymmetrical structural lesions. Multinomial analysis demonstrated that dogs that were older at seizure onset were significantly more likely to have an asymmetrical structural lesion than EUO (OR 95% CI: 1.4-1.8). Dogs that had single seizures rather than cluster seizures were less likely to have asymmetrical structural lesions than dogs with EUO (OR 95% CI: 0.2-0.7). Dogs with abnormal neurological examinations were 16.5 times more likely to have asymmetrical structural lesions (OR 95% CI: 8.5-32.1) and 12.5 times more likely to have symmetrical structural lesions (OR 95% CI: 3.0-52.3) than EUO. These findings support the importance of considering interictal neurological deficits and seizure history in clinical reasoning.

  8. Studying an Eulerian Computer Model on Different High-performance Computer Platforms and Some Applications

    Science.gov (United States)

    Georgiev, K.; Zlatev, Z.

    2010-11-01

    The Danish Eulerian Model (DEM) is an Eulerian model for studying the transport of air pollutants on large scale. Originally, the model was developed at the National Environmental Research Institute of Denmark. The model computational domain covers Europe and some neighbour parts belong to the Atlantic Ocean, Asia and Africa. If DEM model is to be applied by using fine grids, then its discretization leads to a huge computational problem. This implies that such a model as DEM must be run only on high-performance computer architectures. The implementation and tuning of such a complex large-scale model on each different computer is a non-trivial task. Here, some comparison results of running of this model on different kind of vector (CRAY C92A, Fujitsu, etc.), parallel computers with distributed memory (IBM SP, CRAY T3E, Beowulf clusters, Macintosh G4 clusters, etc.), parallel computers with shared memory (SGI Origin, SUN, etc.) and parallel computers with two levels of parallelism (IBM SMP, IBM BlueGene/P, clusters of multiprocessor nodes, etc.) will be presented. The main idea in the parallel version of DEM is domain partitioning approach. Discussions according to the effective use of the cache and hierarchical memories of the modern computers as well as the performance, speed-ups and efficiency achieved will be done. The parallel code of DEM, created by using MPI standard library, appears to be highly portable and shows good efficiency and scalability on different kind of vector and parallel computers. Some important applications of the computer model output are presented in short.

  9. A newly designed 45 to 60 mer oligonucleotide Agilent platform microarray for global gene expression studies of Synechocystis PCC6803: example salt stress experiment

    NARCIS (Netherlands)

    Aguirre von Wobeser, E.; Huisman, J.; Ibelings, B.; Matthijs, H.C.P.; Matthijs, H.C.P.

    2005-01-01

    A newly designed 45 to 60 mer oligonucleotide Agilent platform microarray for global gene expression studies of Synechocystis PCC6803: example salt stress experiment Eneas Aguirre-von-Wobeser 1, Jef Huisman1, Bas Ibelings2 and Hans C.P. Matthijs1 1 Universiteit van Amsterdam, Amsterdam, The Netherla

  10. The development of cross disciplinary studies in cosmology and particle physics on the platform of a Scientific-Educational complex of Virtual Institute of Astroparticle physics (VIA)

    Science.gov (United States)

    Khlopov, M. Yu

    2016-02-01

    The overview of the main problems and methods of cosmoparticle physics, studying fundamental relationship of micro- and macro-worlds, is accompanied by the demonstration of the facility of Virtual Institute of Astroparticle physics (VIA) activity as a well proven platform for scientific collaborative work and education at distance.

  11. The use of a game-based learning platform to engage nursing students: A descriptive, qualitative study.

    Science.gov (United States)

    Gallegos, Cara; Tesar, Abigail J; Connor, Kelley; Martz, Kim

    2017-08-30

    Baccalaureate nursing programs require students to complete a research course, and faculty find it challenging to engage students. Educational gaming has recently gained attention as a technique to motivate students and enhance learning. The purpose of this pilot study was to describe undergraduate nursing students' reflections of their experiences with 3D Gamelab(©), a game-based learning platform. A descriptive qualitative research design was used to elicit students' reflections of their experiences. Educational content such as handouts, videos, activities, and recommended resources for a required junior level nursing research course was organized into quests for use in 3D GameLab(©). At the end of the semester, students were invited to give their feedback through a survey with open-ended questions. Thematic analysis resulted in the following components of the game-based learning experience: navigation, motivation, gaming concept, knowledge, technology, and target population. Although the overall response to 3D GameLab(©) in this course was negative, game-based learning does have the potential to engage students and enhance learning. To better understand how educational gaming could be used in nursing, further research should be conducted to determine the most motivating elements and the types of course content best delivered in this manner. Copyright © 2017. Published by Elsevier Ltd.

  12. Management of teaching processes using the Share point platform: A case study from the University of Split School of Medicine

    Directory of Open Access Journals (Sweden)

    Damir Sapunar

    2016-05-01

    Full Text Available Objective. To develop a software tool that will combine teaching timetables with the generation of reports on teaching load. Methods. The University of Split School of Medicine project team and the external experts from the company LAMA, LLC. determined necessary functionalities and developed the software platform as an extension of the existing software solutions already in use by the Croatian academic community. Results. By combining comprehensive scheduling functionality with planned and performed teaching activities we determined the teaching load and realized automatic generation of payments for adjunct lecturers. The implementation required perfecting of the human resources services, brought about a manifold alleviation of the work of the entire school’s administration and substantially increased the effectiveness of the quality management. The software is currently managing 54,676 teaching hours, 841 teaching staff member, 111 teaching rooms, 8 study programs, and 645 courses. Conclusion. The program resolved several administrative problems of the school and is an example of successful implementation of IT technology in medical school management.

  13. HEK293 cell culture media study towards bioprocess optimization: Animal derived component free and animal derived component containing platforms.

    Science.gov (United States)

    Liste-Calleja, Leticia; Lecina, Martí; Cairó, Jordi Joan

    2014-04-01

    The increasing demand for biopharmaceuticals produced in mammalian cells has lead industries to enhance bioprocess volumetric productivity through different strategies. Among those strategies, cell culture media development is of major interest. In the present work, several commercially available culture media for Human Embryonic Kidney cells (HEK293) were evaluated in terms of maximal specific growth rate and maximal viable cell concentration supported. The main objective was to provide different cell culture platforms which are suitable for a wide range of applications depending on the type and the final use of the product obtained. Performing simple media supplementations with and without animal derived components, an enhancement of cell concentration from 2 × 10(6) cell/mL to 17 × 10(6) cell/mL was achieved in batch mode operation. Additionally, the media were evaluated for adenovirus production as a specific application case of HEK293 cells. None of the supplements interfered significantly with the adenovirus infection although some differences were encountered in viral productivity. To the best of our knowledge, the high cell density achieved in the work presented has never been reported before in HEK293 batch cell cultures and thus, our results are greatly promising to further study cell culture strategies in bioreactor towards bioprocess optimization. Copyright © 2013 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

  14. Multi-parametric surface plasmon resonance platform for studying liposome-serum interactions and protein corona formation.

    Science.gov (United States)

    Kari, Otto K; Rojalin, Tatu; Salmaso, Stefano; Barattin, Michela; Jarva, Hanna; Meri, Seppo; Yliperttula, Marjo; Viitala, Tapani; Urtti, Arto

    2017-04-01

    When nanocarriers are administered into the blood circulation, a complex biomolecular layer known as the "protein corona" associates with their surface. Although the drivers of corona formation are not known, it is widely accepted that this layer mediates biological interactions of the nanocarrier with its surroundings. Label-free optical methods can be used to study protein corona formation without interfering with its dynamics. We demonstrate the proof-of-concept for a multi-parametric surface plasmon resonance (MP-SPR) technique in monitoring the formation of a protein corona on surface-immobilized liposomes subjected to flowing 100 % human serum. We observed the formation of formulation-dependent "hard" and "soft" coronas with distinct refractive indices, layer thicknesses, and surface mass densities. MP-SPR was also employed to determine the affinity (K D ) of a complement system molecule (C3b) with cationic liposomes with and without polyethylene glycol. Tendency to create a thick corona correlated with a higher affinity of opsonin C3b for the surface. The label-free platform provides a fast and robust preclinical tool for tuning nanocarrier surface architecture and composition to control protein corona formation.

  15. Consensus definitions and application guidelines for control groups in cerebrospinal fluid biomarker studies in multiple sclerosis

    DEFF Research Database (Denmark)

    Teunissen, Charlotte; Menge, Til; Altintas, Ayse

    2013-01-01

    definitions and nomenclature for the following groups: healthy controls (HCs), spinal anesthesia subjects (SASs), inflammatory neurological disease controls (INDCs), peripheral inflammatory neurological disease controls (PINDCs), non-inflammatory neurological controls (NINDCs), symptomatic controls (SCs...

  16. Enterprise Social Media: Definition, History, and Prospects for the Study of Social Technologies in Organizations

    National Research Council Canada - National Science Library

    Leonardi, Paul M; Huysman, Marleen; Steinfield, Charles

    2013-01-01

    ... and perpetuate organizations. We begin by offering a definition of enterprise social media and providing a rough historical account of the various avenues through which these technologies have entered and continue to enter the workplace...

  17. Context Management Platform for Tourism Applications

    Science.gov (United States)

    Buján, David; Martín, David; Torices, Ortzi; López-de-Ipiña, Diego; Lamsfus, Carlos; Abaitua, Joseba; Alzua-Sorzabal, Aurkene

    2013-01-01

    The notion of context has been widely studied and there are several authors that have proposed different definitions of context. However, context has not been widely studied in the framework of human mobility and the notion of context has been imported directly from other computing fields without specifically addressing the tourism domain requirements. In order to store and manage context information a context data model and a context management platform are needed. Ontologies have been widely used in context modelling, but many of them are designed to be applied in general ubiquitous computing environments, do not contain specific concepts related to the tourism domain or some approaches do not contain enough concepts to represent context information related to the visitor on the move. That is why we propose a new approach to provide a better solution to model context data in tourism environments, adding more value to our solution reusing data about tourist resources from an Open Data repository and publishing it as Linked Data. We also propose the architecture for a context information management platform based on this context data model. PMID:23797739

  18. Context management platform for tourism applications.

    Science.gov (United States)

    Buján, David; Martín, David; Torices, Ortzi; López-de-Ipiña, Diego; Lamsfus, Carlos; Abaitua, Joseba; Alzua-Sorzabal, Aurkene

    2013-06-24

    The notion of context has been widely studied and there are several authors that have proposed different definitions of context. However, context has not been widely studied in the framework of human mobility and the notion of context has been imported directly from other computing fields without specifically addressing the tourism domain requirements. In order to store and manage context information a context data model and a context management platform are needed. Ontologies have been widely used in context modelling, but many of them are designed to be applied in general ubiquitous computing environments, do not contain specific concepts related to the tourism domain or some approaches do not contain enough concepts to represent context information related to the visitor on the move. That is why we propose a new approach to provide a better solution to model context data in tourism environments, adding more value to our solution reusing data about tourist resources from an Open Data repository and publishing it as Linked Data. We also propose the architecture for a context information management platform based on this context data model.

  19. T2D-Db: An integrated platform to study the molecular basis of Type 2 diabetes

    Directory of Open Access Journals (Sweden)

    Sriram S

    2008-07-01

    Full Text Available Abstract Background Type 2 Diabetes Mellitus (T2DM is a non insulin dependent, complex trait disease that develops due to genetic predisposition and environmental factors. The advanced stage in type 2 diabetes mellitus leads to several micro and macro vascular complications like nephropathy, neuropathy, retinopathy, heart related problems etc. Studies performed on the genetics, biochemistry and molecular biology of this disease to understand the pathophysiology of type 2 diabetes mellitus has led to the generation of a surfeit of data on candidate genes and related aspects. The research is highly progressive towards defining the exact etiology of this disease. Results T2D-Db (Type 2 diabetes Database is a comprehensive web resource, which provides integrated and curated information on almost all known molecular components involved in the pathogenesis of type 2 diabetes mellitus in the three widely studied mammals namely human, mouse and rat. Information on candidate genes, SNPs (Single Nucleotide Polymorphism in candidate genes or candidate regions, genome wide association studies (GWA, tissue specific gene expression patterns, EST (Expressed Sequence Tag data, expression information from microarray data, pathways, protein-protein interactions and disease associated risk factors or complications have been structured in this on line resource. Conclusion Information available in T2D-Db provides an integrated platform for the better molecular level understanding of type 2 diabetes mellitus and its pathogenesis. Importantly, the resource facilitates graphical presentation of the gene/genome wide map of SNP markers and protein-protein interaction networks, besides providing the heat map diagram of the selected gene(s in an organism across microarray expression experiments from either single or multiple studies. These features aid to the data interpretation in an integrative way. T2D-Db is to our knowledge the first publicly available resource that

  20. A practical platform for blood biomarker study by using global gene expression profiling of peripheral whole blood.

    Directory of Open Access Journals (Sweden)

    Ze Tian

    Full Text Available BACKGROUND: Although microarray technology has become the most common method for studying global gene expression, a plethora of technical factors across the experiment contribute to the variable of genome gene expression profiling using peripheral whole blood. A practical platform needs to be established in order to obtain reliable and reproducible data to meet clinical requirements for biomarker study. METHODS AND FINDINGS: We applied peripheral whole blood samples with globin reduction and performed genome-wide transcriptome analysis using Illumina BeadChips. Real-time PCR was subsequently used to evaluate the quality of array data and elucidate the mode in which hemoglobin interferes in gene expression profiling. We demonstrated that, when applied in the context of standard microarray processing procedures, globin reduction results in a consistent and significant increase in the quality of beadarray data. When compared to their pre-globin reduction counterparts, post-globin reduction samples show improved detection statistics, lowered variance and increased sensitivity. More importantly, gender gene separation is remarkably clearer in post-globin reduction samples than in pre-globin reduction samples. Our study suggests that the poor data obtained from pre-globin reduction samples is the result of the high concentration of hemoglobin derived from red blood cells either interfering with target mRNA binding or giving the pseudo binding background signal. CONCLUSION: We therefore recommend the combination of performing globin mRNA reduction in peripheral whole blood samples and hybridizing on Illumina BeadChips as the practical approach for biomarker study.

  1. Critical appraisal of the International Study Group of Pancreatic Surgery (ISGPS) consensus definition of postoperative hemorrhage after pancreatoduodenectomy.

    Science.gov (United States)

    Welsch, Thilo; Eisele, Hanna; Zschäbitz, Stefanie; Hinz, Ulf; Büchler, Markus W; Wente, Moritz N

    2011-08-01

    Postpancreatectomy hemorrhage (PPH) is one of the most serious complications after pancreatoduodenectomy (PD). This study analyzed and validated the International Study Group of Pancreatic Surgery (ISGPS) definition of PPH and aimed to identify risk factors for early (<24 h) and late PPH. Patients who underwent PD for pancreatic head tumors between 2001 and 2008 were included and complications were prospectively recorded. Factors associated with PPH were assessed by uni- and multivariate analysis. Complete datasets were available for 796 patients. Classic and pylorus-preserving PD was performed in 13.8% and 86.2% of the patients, respectively. According to the ISGPS definition, PPH occurred in 29.1% of the cases (232 of 796 patients): 4.8% grade A, 15.2% grade B, and 9.2% grade C. The definition is based largely on surrogate markers (e.g., transfusion requirement) that are affected by other critical illnesses and more than 97% of patients with mild PPH had no clinical signs of bleeding. The need for postoperative intensive care as well as the incidence of pancreatic fistula, relaparotomy, and mortality rates significantly increased from grades A to C. Thirty-seven patients (4.6%) required interventional (endoscopy or angiography) and/or relaparotomy for PPH. Relaparotomy for PPH was performed in 3.1% of all patients. Independent risk factors for early PPH were preoperative anemia (hemoglobin, <11 mg/dl) and multivisceral resection while advanced age, chronic renal insufficiency, increased blood loss, and long operation time were associated with late PPH. The ISGPS definition of PPH is feasible and applicable but produces a high rate of false positive mild PPH cases. The different grades still significantly correlate with relevant outcome variables, thus the definition discriminates postoperative courses, but a minor modification of the definition of mild PPH is suggested. The new results further demonstrate the need to optimize preoperative anemia and chronic renal

  2. Problems Associated with Coordination and Role Definitions in Health Care Teams: A Hospice Program Evaluation and Intervention Case Study.

    Science.gov (United States)

    Berteotti, Carol R.; And Others

    Using an evaluation of a hospital-based hospice as a case study, this paper analyzes problematic issues surrounding health care teams (HCTs) in light of findings revealed in the literature concerning HCT structures and processes. The factors of coordination and role definitions in HCTs and their manifestations in a particular hospice HCT in terms…

  3. Cost optimal and nearly zero-energy buildings (nZEB) definitions, calculation principles and case studies

    CERN Document Server

    Kurnitski, Jarek

    2013-01-01

    This book introduces technical definitions, system boundaries, energy calculation methods and input data for setting primary energy based minimum/cost optimal and nZEB requirements in national energy frames. Offers five case studies of nZEB office buildings.

  4. Towards a Framework of Digital Platform Competition

    DEFF Research Database (Denmark)

    Kazan, Erol; Tan, Chee-Wee; Lim, Eric T. K.

    2016-01-01

    This paper advances a framework for examining the competitive principles of mobile payment platforms. We postulate that the strategic interplay of platform layers will drive the competitive dynamics of platform-driven ubiquitous systems. This framework has been employed in a comparative case study...

  5. Design Thinking and Cloud Manufacturing: A Study of Cloud Model Sharing Platform Based on Separated Data Log

    Directory of Open Access Journals (Sweden)

    Zhe Wei

    2013-01-01

    Full Text Available To solve the product data consistency problem which is caused by the portable system that cannot conduct real-time update of product data in mobile environment under the mass customization production mode, a new product data optimistic replication method based on log is presented. This paper focuses on the design thinking provider, probing into a manufacturing resource design thinking cloud platform based on manufacturing resource-locating technologies, and also discuss several application scenarios of cloud locating technologies in the manufacturing environment. The actual demand of manufacturing creates a new mode which is service-oriented and has high efficiency and low consumption. Finally, they are different from the crowd-sourcing application model of Local-Motors. The sharing platform operator is responsible for a master plan for the platform, proposing a open interface standard and establishing a service operation mode.

  6. Study on Logistics Park EDI platform Construction%物流园区的EDI平台建设初探

    Institute of Scientific and Technical Information of China (English)

    袁惠莉

    2011-01-01

    从EDI的基本技术人手,介绍了EDI平台的相关概念;分析了物流园区EDI平台应具有的功能和可能的技术实现方案;最终得出搭建EDI平台与物流园区发展之间关系的结论.%The paper starts from the basic technology of EDI to introduce the related concepts of EDI platform and analyzes the necessary functions of a logistics park EDI platform and the technical solution. Finally it comments on the relationship between EDI platform construction and logistics park development.

  7. A Comparative Study of Multiple Object Detection Using Haar-Like Feature Selection and Local Binary Patterns in Several Platforms

    Directory of Open Access Journals (Sweden)

    Souhail Guennouni

    2015-01-01

    Full Text Available Object detection has been attracting much interest due to the wide spectrum of applications that use it. It has been driven by an increasing processing power available in software and hardware platforms. In this work we present a developed application for multiple objects detection based on OpenCV libraries. The complexity-related aspects that were considered in the object detection using cascade classifier are described. Furthermore, we discuss the profiling and porting of the application into an embedded platform and compare the results with those obtained on traditional platforms. The proposed application deals with real-time systems implementation and the results give a metric able to select where the cases of object detection applications may be more complex and where it may be simpler.

  8. What is my walking neighbourhood? A pilot study of English adults' definitions of their local walking neighbourhoods

    Directory of Open Access Journals (Sweden)

    Davey Rachel

    2010-05-01

    Full Text Available Abstract Background Existing measures of perceptions of the environment associated with walking commonly rely on providing a definition of 'neighbourhood', e.g. 1 mile area around the home. We have little understanding of how these examples relate with adults' own geographical definitions of their neighbourhood area. Our pilot study examined the congruence between definitions used in environmental questionnaires and adults' own definitions of neighbourhood. Methods We conducted 58 face-to-face interviews with participants randomly selected from 10 areas of Stoke-on-Trent, England. Participants were shown printed maps showing their local area with road names and places of interest (e.g. shops, services, green space and were asked: (i to recall usual walking destinations (from their home; (ii to draw their 'neighbourhood walking area' on the map. Annotated maps were scanned back into GIS for analysis. Results When asked to draw their 'neighbourhood' boundary, the resulting area drawn by participants on average represented only 16 ± 20% of the commonly used total straight-line buffer of 1 mile (or 1.6 km with a range of 0.3% to 111%. Even when repeated using a network buffer (rather than straight-line the same comparison resulted in a mean of 36% (± 47% and a range of 0.6 to 245%. Conclusions We found that adults' interpretation of their neighbourhood area does not appear to relate accurately to the definitions typically used in research into environmental perceptions and walking. This mis-match warrants further investigation as definitions used in existing measures may be consistently misclassifying perceived local walking neighbourhoods.

  9. An EULAR study group pilot study on reliability of simple capillaroscopic definitions to describe capillary morphology in rheumatic diseases.

    Science.gov (United States)

    Smith, Vanessa; Beeckman, Sam; Herrick, Ariane L; Decuman, Saskia; Deschepper, Ellen; De Keyser, Filip; Distler, Oliver; Foeldvari, Ivan; Ingegnoli, Francesca; Müller-Ladner, Ulf; Riccieri, Valeria; Riemekasten, Gabriela; Sulli, Alberto; Voskuyl, Alexandre; Cutolo, Maurizio

    2016-05-01

    To propose simple capillaroscopic definitions for interpretation of capillaroscopic morphologies and to assess inter-rater reliability. The simple definitions proposed were: normal--hairpin, tortuous or crossing; abnormal--not hairpin, not tortuous and not crossing; not evaluable--whenever rater undecided between normal and abnormal. Based upon an aimed kappa of 0.80 and default prevalences of normal (0.4), abnormal (0.4) and not evaluable (0.2) capillaries, 90 single capillaries were presented to three groups of raters: experienced independent raters, n = 5; attendees of the sixth EULAR capillaroscopy course, n = 34; novices after a 1-h course, n = 11. Inter-rater agreement was assessed by calculation of proportion of agreement and by kappa coefficients. Mean kappa based on 90 capillaries was 0.47 (95% CI: 0.39, 0.54) for expert raters, 0.40 (95% CI: 0.36, 0.44) for attendees and 0.46 (95% CI: 0.41, 0.52) for novices, with overall agreements of 67% (95% CI: 63, 71), 63% (95% CI: 60, 65) and 67% (95% CI: 63, 70), respectively. Comparing only normal vs the combined groups of abnormal and not evaluable capillaries did increase the kappa: 0.51 (95% CI: 0.37 ,: 0.65), 0.53 (95% CI: 0.49, 0.58) and 0.55 (95% CI: 0.49, 0.62). On the condition that the capillaries were classifiable, the mean kappa was 0.62 (95% CI: 0.50, 0.74) for expert raters (n = 65), 0.76 (95% CI: 0.69, 0.83) for attendees (n = 20) and 0.81 (95% CI: 0.74, 0.89) for novices (n = 44). This multicentre, international study showed moderate reliability of simple capillaroscopic definitions for describing morphology of capillaries by rheumatologists with varying levels of expertise. Novices were capable of distinguishing normal from abnormal capillaries by means of a 1-h training session. In future studies, the class not evaluable may be obsolete. © The Author 2016. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email

  10. The Logic of Digital Platform Disruption

    DEFF Research Database (Denmark)

    Kazan, Erol; Tan, Chee-Wee; Lim, Eric T. K.

    Digital platforms are disruptive IT artifacts, because they facilitate the quick release of innovative platform derivatives from third parties (e.g., apps). This study endeavours to unravel the disruptive potential, caused by distinct designs and configurations of digital platforms on market...... environments. We postulate that the disruptive potential of digital platforms is determined by the degree of alignment among the business, technology and platform profiles. Furthermore, we argue that the design and configuration of the aforementioned three elements dictates the extent to which open innovation...... is permitted. To shed light on the disruptive potential of digital platforms, we opted for payment platforms as our unit of analysis. Through interviews with experts and payment providers, we seek to gain an in-depth appreciation of how contemporary digital payment platforms are designed and configured...

  11. The Logic of Digital Platform Disruption

    DEFF Research Database (Denmark)

    Kazan, Erol; Tan, Chee-Wee; Lim, Eric T. K.

    Digital platforms are disruptive IT artifacts, because they facilitate the quick release of innovative platform derivatives from third parties (e.g., apps). This study endeavours to unravel the disruptive potential, caused by distinct designs and configurations of digital platforms on market...... environments. We postulate that the disruptive potential of digital platforms is determined by the degree of alignment among the business, technology and platform profiles. Furthermore, we argue that the design and configuration of the aforementioned three elements dictates the extent to which open innovation...... is permitted. To shed light on the disruptive potential of digital platforms, we opted for payment platforms as our unit of analysis. Through interviews with experts and payment providers, we seek to gain an in-depth appreciation of how contemporary digital payment platforms are designed and configured...

  12. Common tester platform concept.

    Energy Technology Data Exchange (ETDEWEB)

    Hurst, Michael James

    2008-05-01

    This report summarizes the results of a case study on the doctrine of a common tester platform, a concept of a standardized platform that can be applicable across the broad spectrum of testing requirements throughout the various stages of a weapons program, as well as across the various weapons programs. The common tester concept strives to define an affordable, next-generation design that will meet testing requirements with the flexibility to grow and expand; supporting the initial development stages of a weapons program through to the final production and surveillance stages. This report discusses a concept investing key leveraging technologies and operational concepts combined with prototype tester-development experiences and practical lessons learned gleaned from past weapons programs.

  13. A pilot study evaluating use of a computer-assisted neurorehabilitation platform for upper-extremity stroke assessment

    Directory of Open Access Journals (Sweden)

    Feng Xin

    2009-05-01

    Full Text Available Abstract Background There is a need to develop cost-effective, sensitive stroke assessment instruments. One approach is examining kinematic measures derived from goal-directed tasks, which can potentially be sensitive to the subtle changes in the stroke rehabilitation process. This paper presents the findings from a pilot study that uses a computer-assisted neurorehabilitation platform, interfaced with a conventional force-reflecting joystick, to examine the assessment capability of the system by various types of goal-directed tasks. Methods Both stroke subjects with hemiparesis and able-bodied subjects used the force-reflecting joystick to complete a suite of goal-directed tasks under various task settings. Kinematic metrics, developed for specific types of goal-directed tasks, were used to assess various aspects of upper-extremity motor performance across subjects. Results A number of metrics based on kinematic performance were able to differentiate subjects with different impairment levels, with metrics associated with accuracy, steadiness and speed consistency showing the best capability. Significant differences were also shown on these metrics between various force field settings. Conclusion The results support the potential of using UniTherapy software with a conventional joystick system as an upper-extremity assessment instrument. We demonstrated the ability of using various types of goal-directed tasks to distinguish between subjects with different impairment levels. In addition, we were able to show that different force fields have a significant effect on the performance across subjects with different impairment levels in the trajectory tracking task. These results provide motivation for studies with a larger sample size that can more completely span the impairment space, and can use insights presented here to refine considerations of various task settings so as to generalize and extend our conclusions.

  14. Cell_motility: a cross-platform, open source application for the study of cell motion paths

    Directory of Open Access Journals (Sweden)

    Gevaert Kris

    2006-06-01

    Full Text Available Abstract Background Migration is an important aspect of cellular behaviour and is therefore widely studied in cell biology. Numerous components are known to participate in this process in a highly dynamic manner. In order to obtain a better insight in cell migration, mutants or drugs are used and their motive phenotype is then linked with the disturbing factors. One of the typical approaches to study motion paths of individual cells relies on fitting mean square displacements to a persistent random walk function. Since the numerous calculations involved often rely on diverse commercial software packages, the analysis can be expensive, labour-intensive and error-prone work. Additionally, due to the nature of algorithms employed the calculations involved are not readily reproducible without access to the exact software package(s used. Results We here present the cell_motility software, an open source Java application under the GNU-GPL license that provides a clear and concise analysis workbench for large amounts of cell motion data. Apart from performing the necessary calculations, the software also visualizes the original motion paths as well as the results of the calculations to help the user interpret the data. The application features an intuitive graphical user interface as well as full user and developer documentation and both source and binary files can be freely downloaded from the project website at http://genesis.UGent.be/cell_motility . Conclusion In providing a free, open source software solution for the automated processing of cell motion data, we aim to achieve two important goals: labs can greatly simplify their data analysis pipeline as switching between different computational software packages becomes obsolete (thus reducing the chances for human error during data manipulation and transfer and secondly, to provide scientists in the field with a freely available common platform to perform their analyses, enabling more efficient

  15. Astronomy sortie missions definition study. Volume 3, book 1: Design analysis and trade studies

    Science.gov (United States)

    1972-01-01

    A study to define the astronomy sortie missions was conducted. The design analyses and tradeoff studies conducted for candidate concepts are presented. The subjects discussed are: (1) system and subsystem requirements, (2) space shuttle interfaces, (3) infrared telescope development, and (4) experiments to be conducted during the mission.

  16. NASA's geostationary communications platform program

    Science.gov (United States)

    Ramler, J.; Durrett, R.

    1984-01-01

    This paper reviews recent trends in communications satellites and explains NASA's current interest in geostationary communications platforms. Large communications platforms capable of supporting multiple payloads with common utilities have been examined in a number of studies since 1974 and appear to offer a number of potential advantages. In 1981, an Industry Briefing and Workshop sponsord by NASA focused on the institutional, operational and technical issues that will influence the implementation of geostationary platforms. The workshop identified numerous issues and problem areas that needed more detailed study. To address the issues/problems identified, a NASA geostationary communications platform program has been developed. This program is described, focusing on the initial studies to be performed.

  17. Paradigm change in ocean studies: multi-platform observing and forecasting integrated approach in response to science and society needs

    Science.gov (United States)

    Tintoré, Joaquín

    2017-04-01

    The last 20 years of ocean research have allowed a description of the state of the large-scale ocean circulation. However, it is also well known that there is no such thing as an ocean state and that the ocean varies a wide range of spatial and temporal scales. More recently, in the last 10 years, new monitoring and modelling technologies have emerged allowing quasi real time observation and forecasting of the ocean at regional and local scales. Theses new technologies are key components of recent observing & forecasting systems being progressively implemented in many regional seas and coastal areas of the world oceans. As a result, new capabilities to characterise the ocean state and more important, its variability at small spatial and temporal scales, exists today in many cases in quasi-real time. Examples of relevance for society can be cited, among others our capabilities to detect and understand long-term climatic changes and also our capabilities to better constrain our forecasting capabilities of the coastal ocean circulation at temporal scales from sub-seasonal to inter-annual and spatial from regional to meso and submesoscale. The Mediterranean Sea is a well-known laboratory ocean where meso and submesoscale features can be ideally observed and studied as shown by the key contributions from projects such as Perseus, CMEMS, Jericonext, among others. The challenge for the next 10 years is the integration of theses technologies and multiplatform observing and forecasting systems to (a) monitor the variability at small scales mesoscale/weeks) in order (b) to resolve the sub-basin/seasonal and inter-annual variability and by this (c) establish the decadal variability, understand the associated biases and correct them. In other words, the new observing systems now allow a major change in our focus of ocean observation, now from small to large scales. Recent studies from SOCIB -www.socib.es- have shown the importance of this new small to large-scale multi-platform

  18. 海洋平台结构振动控制研究综述%Review on the Study of Structure Vibration Control for Offshore Platforms

    Institute of Scientific and Technical Information of China (English)

    肖宇维; 孙树民

    2012-01-01

    The vibration of offshore platforms will harm staff's physical and mental health, cause fatigue and destruction of the structure, reduce practicality, survivability and maneuverability of offshore platforms and bring a series of threat to oil mining. This paper mainly introduces the study and application status of structure vibration control of offshore platforms and focuses on the passive control, active control and semi-active control technology. Finally some problems on structure vibration control offshore platforms are puts forward.%海洋平台结构的振动将会影响工作人员的身心健康,导致结构疲劳和破坏,降低平台的实用性、生存性以及可操作性,给海上油气顺利开采带来一系列的威胁。本文主要对海洋平台结构振动控制的研究和应用现状做了简要的介绍,并重点介绍了被动控制、主动控制以及半主动控制技术。最后提出了海洋平台结构振动控制存在的一些问题。

  19. Study on the Standard Definitions and Methods of Energy Supply and Demand Statistics

    Energy Technology Data Exchange (ETDEWEB)

    Park, T.S. [Korea Energy Economics Institute, Euiwang (Korea)

    2001-11-01

    It is no doubt that a successful national energy policy depends on how deeply is understood the structure of energy supply and demand. It, however, is quite difficult to make out the precise statistics of the energy supply and demand statistics without the technical knowledge. We need to consider reporting the energy statistics as constructing an infrastructure in its field. With several revisions of reporting data system, the energy statistics have been developed, but they still have many problems due to the shortage of energy statistic data. This study indicates the technical problems of reporting system by energy sources and suggests the improving ways about how to collect and report energy supply and demand statistics. Concerning the statistics of oil supply and demand, this study suggests definition and reporting methods on the annual oil statistics of IEA and shows revised data on the national report submitted to IEA 2000. Also to calculate precise coal supply and demand, coal conversion processes, relationship of inputs of coking coal through coke oven coke, COG and BFG are considered in this study. To include auto-producer electricity and heat for sale in the transformation sector of energy balance, related data are collected and how much is used for electricity generation and heat for sale are estimated. To avoid double counting, it shows how each amount is subtracted from the corresponding sector. In order to a success of establishing energy policies and strategies, they need to be based on the well-framed statistics on energy supply and demand. Therefore we all should keep in mind that continuing interests and supports are necessary to set up the energy data system. And to develop the energy statistical system, more consistent institutional framework is necessary to be established along with the technical solution. (author). 23 refs., 11 figs., 45 tabs.

  20. Study on a Mechanical Semi-Active Heave Compensation System of Drill String for Use on Floating Drilling Platform.

    Directory of Open Access Journals (Sweden)

    Qingyou Liu

    Full Text Available There are some disadvantages for existing heave compensation systems of drill string used for the Floating Drilling Platform (FDP, including high energy consumption, large and complex structure, and expensive manufacturing and maintenance costs. In view of the above, we present a streamlined mechanical semi-active heave compensation system (MSAHC in this study. This system consists of active compensation part with the pinion and rack and passive compensation part. In order to evaluate system performance of the MSAHC, we establish its simulation model with AMEsim software. In the process of simulation, displacement of rotary hook and energy consumption is regarded as performance parameters of the system. And the change rule of two performance parameters are analyzed by changing these design parameters including gear radius of the pinion and rack, scale coefficient of PID, rotary hook load, heave height and heave period of the FDP, and accumulator volume. Then, based on the simulation results of the MSAHC system performance, we have selected out a best set of design parameters from them. Moreover, the feasibility of the design scheme of the MSAHC is effectively verified by comparison with the existing three heave compensation system. The result shows that the energy consumption of the MSAHC is lower than the active heave compensation system (AHC and the semi-active heave compensation system (SAHC when achieving a same compensation effect as well as the accumulator volume of MSAHC is half of the passive heave compensation system (PHC. Therefore, the new designed MSAHC not only ensure compensation effect but also lower energy consumption, and its structure is simplified by adopting the simple mechanical structure to decrease manufacturing cost, maintenance cost and floor space.

  1. The VAMOS Ocean-Cloud-Atmosphere-Land Study Regional Experiment (VOCALS-REx): goals, platforms, and field operations

    Science.gov (United States)

    Wood, R.; Mechoso, C. R.; Bretherton, C. S.; Weller, R. A.; Huebert, B.; Straneo, F.; Albrecht, B. A.; Coe, H.; Allen, G.; Vaughan, G.; Daum, P.; Fairall, C.; Chand, D.; Gallardo Klenner, L.; Garreaud, R.; Grados, C.; Covert, D. S.; Bates, T. S.; Krejci, R.; Russell, L. M.; de Szoeke, S.; Brewer, A.; Yuter, S. E.; Springston, S. R.; Chaigneau, A.; Toniazzo, T.; Minnis, P.; Palikonda, R.; Abel, S. J.; Brown, W. O. J.; Williams, S.; Fochesatto, J.; Brioude, J.; Bower, K. N.

    2011-01-01

    The VAMOS1 Ocean-Cloud-Atmosphere-Land Study Regional Experiment (VOCALS-REx) was an international field program designed to make observations of poorly understood but critical components of the coupled climate system of the southeast Pacific. This region is characterized by strong coastal upwelling, the coolest SSTs in the tropical belt, and is home to the largest subtropical stratocumulus deck on Earth. The field intensive phase of VOCALS-REx took place during October and November 2008 and constitutes a critical part of a broader CLIVAR program (VOCALS) designed to develop and promote scientific activities leading to improved understanding, model simulations, and predictions of the southeastern Pacific (SEP) coupled ocean-atmosphere-land system, on diurnal to interannual timescales. The other major components of VOCALS are a modeling program with a model hierarchy ranging from the local to global scales, and a suite of extended observations from regular research cruises, instrumented moorings, and satellites. The two central themes of VOCALS-REx focus upon (a) links between aerosols, clouds and precipitation and their impacts on marine stratocumulus radiative properties, and (b) physical and chemical couplings between the upper ocean and the lower atmosphere, including the role that mesoscale ocean eddies play. A set of hypotheses designed to be tested with the combined field, monitoring and modeling work in VOCALS is presented here. A further goal of VOCALS-REx is to provide datasets for the evaluation and improvement of large-scale numerical models. VOCALS-REx involved five research aircraft, two ships and two surface sites in northern Chile. We describe the instrument payloads and key mission strategies for these platforms and give a summary of the missions conducted. 1 Variability of the American Monsoon Systems, an international CLIVAR program.

  2. The VAMOS Ocean-Cloud-Atmosphere-Land Study Regional Experiment (VOCALS-REx: goals, platforms, and field operations

    Directory of Open Access Journals (Sweden)

    R. Wood

    2011-01-01

    Full Text Available The VAMOS1 Ocean-Cloud-Atmosphere-Land Study Regional Experiment (VOCALS-REx was an international field program designed to make observations of poorly understood but critical components of the coupled climate system of the southeast Pacific. This region is characterized by strong coastal upwelling, the coolest SSTs in the tropical belt, and is home to the largest subtropical stratocumulus deck on Earth. The field intensive phase of VOCALS-REx took place during October and November 2008 and constitutes a critical part of a broader CLIVAR program (VOCALS designed to develop and promote scientific activities leading to improved understanding, model simulations, and predictions of the southeastern Pacific (SEP coupled ocean-atmosphere-land system, on diurnal to interannual timescales. The other major components of VOCALS are a modeling program with a model hierarchy ranging from the local to global scales, and a suite of extended observations from regular research cruises, instrumented moorings, and satellites. The two central themes of VOCALS-REx focus upon (a links between aerosols, clouds and precipitation and their impacts on marine stratocumulus radiative properties, and (b physical and chemical couplings between the upper ocean and the lower atmosphere, including the role that mesoscale ocean eddies play. A set of hypotheses designed to be tested with the combined field, monitoring and modeling work in VOCALS is presented here. A further goal of VOCALS-REx is to provide datasets for the evaluation and improvement of large-scale numerical models. VOCALS-REx involved five research aircraft, two ships and two surface sites in northern Chile. We describe the instrument payloads and key mission strategies for these platforms and give a summary of the missions conducted.

    1 Variability of the American Monsoon Systems, an international CLIVAR program.

  3. The VAMOS Ocean-Cloud-Atmosphere-Land Study Regional Experiment (VOCALS-REx: goals, platforms, and field operations

    Directory of Open Access Journals (Sweden)

    R. Wood

    2010-09-01

    Full Text Available The VAMOS Ocean-Cloud-Atmosphere-Land Study Regional Experiment (VOCALS-REx was an international field program designed to make observations of poorly understood but critical components of the coupled climate system of the southeast Pacific. This region is characterized by strong coastal upwelling, the coolest SSTs in the tropical belt, and is home to the largest subtropical stratocumulus deck on Earth. The field intensive phase of VOCALS-REx took place during October and November 2008 and constitutes a critical part of a broader CLIVAR program (VOCALS designed to develop and promote scientific activities leading to improved understanding, model simulations, and predictions of the southeastern Pacific (SEP coupled ocean-atmosphere-land system, on diurnal to interannual timescales. The other major components of VOCALS are a modeling program with a model hierarchy ranging from the local to global scales, and a suite of extended observations from regular research cruises, instrumented moorings, and satellites.

    The two central themes of VOCALS-REx are designed to improve understanding of (a links between aerosols, clouds and precipitation and their impacts on marine stratocumulus radiative properties, and (b physical and chemical couplings between the upper ocean and the lower atmosphere, including the role that mesoscale ocean eddies play. A set of hypotheses designed to be tested with the combined field, monitoring and modeling work in VOCALS is presented here. VOCALS-REx involved five research aircraft, two ships and two surface sites in northern Chile. We describe the instrument payloads and key mission strategies for these platforms and given a summary of the missions conducted.

  4. The VAMOS Ocean-Cloud-Atmosphere-Land Study Regional Experiment (VOCALS-REx): Goals, platforms, and field operations

    Energy Technology Data Exchange (ETDEWEB)

    Wood, R.; Springston, S.; Mechoso, C. R.; Bretherton, C. S.; A.Weller, R.; Huebert, B.; Straneo, F.; Albrecht, B. A.; Coe, H.; Allen, G.; Vaughan, G.; Daum, P.; Fairall, C.; Chand, D.; Klenner, L. G.; Garreaud, R.; Grados, C.; Covert, D. S.; Bates, T. S.; Krejci, R.; Russell, L. M.; Szoeke, S. d.; Brewer, A.; Yuter, S. E.; Chaigneau, A.; Toniazzo, T.; Minnis, P.; Palikonda, R.; Abel, S. J.; Brown, W. O. J.; Williams, S.; Fochesatto, J.; Brioude, J.; Bower, K. N

    2011-01-21

    The VAMOS Ocean-Cloud-Atmosphere-Land Study Regional Experiment (VOCALS-REx) was an international field program designed to make observations of poorly understood but critical components of the coupled climate system of the southeast Pacific. This region is characterized by strong coastal upwelling, the coolest SSTs in the tropical belt, and is home to the largest subtropical stratocumulus deck on Earth. The field intensive phase of VOCALS-REx took place during October and November 2008 and constitutes a critical part of a broader CLIVAR program (VOCALS) designed to develop and promote scientific activities leading to improved understanding, model simulations, and predictions of the southeastern Pacific (SEP) coupled ocean-atmosphere-land system, on diurnal to interannual timescales. The other major components of VOCALS are a modeling program with a model hierarchy ranging from the local to global scales, and a suite of extended observations from regular research cruises, instrumented moorings, and satellites. The two central themes of VOCALS-REx focus upon (a) links between aerosols, clouds and precipitation and their impacts on marine stratocumulus radiative properties, and (b) physical and chemical couplings between the upper ocean and the lower atmosphere, including the role that mesoscale ocean eddies play. A set of hypotheses designed to be tested with the combined field, monitoring and modeling work in VOCALS is presented here. A further goal of VOCALS-REx is to provide datasets for the evaluation and improvement of large-scale numerical models. VOCALS-REx involved five research aircraft, two ships and two surface sites in northern Chile. We describe the instrument payloads and key mission strategies for these platforms and give a summary of the missions conducted.

  5. ToxEvaluator: an integrated computational platform to aid the interpretation of toxicology study-related findings.

    Science.gov (United States)

    Pelletier, D; Wiegers, T C; Enayetallah, A; Kibbey, C; Gosink, M; Koza-Taylor, P; Mattingly, C J; Lawton, M

    2016-01-01

    Attempts are frequently made to investigate adverse findings from preclinical toxicology studies in order to better understand underlying toxicity mechanisms. These efforts often begin with limited information, including a description of the adverse finding, knowledge of the structure of the chemical associated with its cause and the intended pharmacological target. ToxEvaluator was developed jointly by Pfizer and the Comparative Toxicogenomics Database (http://ctdbase.org) team at North Carolina State University as an in silico platform to facilitate interpretation of toxicity findings in light of prior knowledge. Through the integration of a diverse set of in silico tools that leverage a number of public and proprietary databases, ToxEvaluator streamlines the process of aggregating and interrogating diverse sources of information. The user enters compound and target identifiers, and selects adverse event descriptors from a safety lexicon and mapped MeSH disease terms. ToxEvaluator provides a summary report with multiple distinct areas organized according to what target or structural aspects have been linked to the adverse finding, including primary pharmacology, structurally similar proprietary compounds, structurally similar public domain compounds, predicted secondary (i.e. off-target) pharmacology and known secondary pharmacology. Similar proprietary compounds and their associated in vivo toxicity findings are reported, along with a link to relevant supporting documents. For similar public domain compounds and interacting targets, ToxEvaluator integrates relationships curated in Comparative Toxicogenomics Database, returning all direct and inferred linkages between them. As an example of its utility, we demonstrate how ToxEvaluator rapidly identified direct (primary pharmacology) and indirect (secondary pharmacology) linkages between cerivastatin and myopathy.

  6. Study on a Mechanical Semi-Active Heave Compensation System of Drill String for Use on Floating Drilling Platform

    Science.gov (United States)

    Liu, Qingyou; Tang, Yang; Huang, Chongjun; Xie, Chong

    2015-01-01

    There are some disadvantages for existing heave compensation systems of drill string used for the Floating Drilling Platform (FDP), including high energy consumption, large and complex structure, and expensive manufacturing and maintenance costs. In view of the above, we present a streamlined mechanical semi-active heave compensation system (MSAHC) in this study. This system consists of active compensation part with the pinion and rack and passive compensation part. In order to evaluate system performance of the MSAHC, we establish its simulation model with AMEsim software. In the process of simulation, displacement of rotary hook and energy consumption is regarded as performance parameters of the system. And the change rule of two performance parameters are analyzed by changing these design parameters including gear radius of the pinion and rack, scale coefficient of PID, rotary hook load, heave height and heave period of the FDP, and accumulator volume. Then, based on the simulation results of the MSAHC system performance, we have selected out a best set of design parameters from them. Moreover, the feasibility of the design scheme of the MSAHC is effectively verified by comparison with the existing three heave compensation system. The result shows that the energy consumption of the MSAHC is lower than the active heave compensation system (AHC) and the semi-active heave compensation system (SAHC) when achieving a same compensation effect as well as the accumulator volume of MSAHC is half of the passive heave compensation system (PHC). Therefore, the new designed MSAHC not only ensure compensation effect but also lower energy consumption, and its structure is simplified by adopting the simple mechanical structure to decrease manufacturing cost, maintenance cost and floor space. PMID:26186620

  7. Microgravity Platforms

    Science.gov (United States)

    Del Basso, Steve

    2000-01-01

    The world's space agencies have been conducting microgravity research since the beginning of space flight. Initially driven by the need to understand the impact of less than- earth gravity physics on manned space flight, microgravity research has evolved into a broad class of scientific experimentation that utilizes extreme low acceleration environments. The U.S. NASA microgravity research program supports both basic and applied research in five key areas: biotechnology - focusing on macro-molecular crystal growth as well as the use of the unique space environment to assemble and grow mammalian tissue; combustion science - focusing on the process of ignition, flame propagation, and extinction of gaseous, liquid, and solid fuels; fluid physics - including aspects of fluid dynamics and transport phenomena; fundamental physics - including the study of critical phenomena, low-temperature, atomic, and gravitational physics; and materials science - including electronic and photonic materials, glasses and ceramics, polymers, and metals and alloys. Similar activities prevail within the Chinese, European, Japanese, and Russian agencies with participation from additional international organizations as well. While scientific research remains the principal objective behind these program, all hope to drive toward commercialization to sustain a long range infrastructure which .benefits the national technology and economy. In the 1997 International Space Station Commercialization Study, conducted by the Potomac Institute for Policy Studies, some viable microgravity commercial ventures were identified, however, none appeared sufficiently robust to privately fund space access at that time. Thus, government funded micro gravity research continues on an evolutionary path with revolutionary potential.

  8. Product Platform Modeling

    DEFF Research Database (Denmark)

    Pedersen, Rasmus

    on the notion that reuse and encapsulation of platform elements are fundamental characteristics of a product platform. Reuse covers the desire to reuse and share certain assets across a family of products and/or across generations of products. Product design solutions and principles are often regarded...... as important assets in a product platform, yet activities, working patterns, processes and knowledge can also be reused in a platform approach. Encapsulation is seen as a process in which the different elements of a platform are grouped into well defined and self-contained units which are decoupled from each......This PhD thesis has the title Product Platform Modelling. The thesis is about product platforms and visual product platform modelling. Product platforms have gained an increasing attention in industry and academia in the past decade. The reasons are many, yet the increasing globalisation...

  9. Astronomy sortie missions definition study. Volume 3, book 2: Appendix: Design analysis and trade studies

    Science.gov (United States)

    1972-01-01

    Backup or supporting data for the design analyses and trade studies which defined the astronomy sortie missions are presented. The subjects discussed are: (1) configuration of space shuttle orbiter, (2) electronic subsystems, (3) electric power requirements, and (4) payload requirements. Mathematical models are developed to illustrate the orbital rendezvous capabilities.

  10. Using GIS servers and interactive maps in spectral data sharing and administration: Case study of Ahvaz Spectral Geodatabase Platform (ASGP)

    Science.gov (United States)

    Karami, Mojtaba; Rangzan, Kazem; Saberi, Azim

    2013-10-01

    With emergence of air-borne and space-borne hyperspectral sensors, spectroscopic measurements are gaining more importance in remote sensing. Therefore, the number of available spectral reference data is constantly increasing. This rapid increase often exhibits a poor data management, which leads to ultimate isolation of data on disk storages. Spectral data without precise description of the target, methods, environment, and sampling geometry cannot be used by other researchers. Moreover, existing spectral data (in case it accompanied with good documentation) become virtually invisible or unreachable for researchers. Providing documentation and a data-sharing framework for spectral data, in which researchers are able to search for or share spectral data and documentation, would definitely improve the data lifetime. Relational Database Management Systems (RDBMS) are main candidates for spectral data management and their efficiency is proven by many studies and applications to date. In this study, a new approach to spectral data administration is presented based on spatial identity of spectral samples. This method benefits from scalability and performance of RDBMS for storage of spectral data, but uses GIS servers to provide users with interactive maps as an interface to the system. The spectral files, photographs and descriptive data are considered as belongings of a geospatial object. A spectral processing unit is responsible for evaluation of metadata quality and performing routine spectral processing tasks for newly-added data. As a result, by using internet browser software the users would be able to visually examine availability of data and/or search for data based on descriptive attributes associated to it. The proposed system is scalable and besides giving the users good sense of what data are available in the database, it facilitates participation of spectral reference data in producing geoinformation.

  11. Study on Platform Ownership in Two-sided Markets%基于双边市场的平台所有权研究

    Institute of Scientific and Technical Information of China (English)

    王昭慧; 张洪

    2011-01-01

    There are many markets in which two groups of users interact with each other via electronic platforms. These platforms enable markets to have two - sided network externality. These platforms include payment systems, portals, search engines, Internet shops, operating systems, etc. The platform of two-sided markets may be owned by independent third parties, or vertically integrated buyers or suppliers. Different ownerships can lead to differences in platform size, profit distribution and social welfare. It is important to understand different forms of platform ownership structure and their external effects.This paper is to study the impact of different platform ownership arrangements on the market structure in two-sided markets. Two ownership structures and three market structures are examined in this study. The two examined ownership structures are the independent third party-owned platform and the supplier-owned platform. The three examined market structures are monopoly, duopoly with single-homing and multi-homing. This study compares the rankings of market size, consumer surplus, supplier's profit and social welfare for these two ownership structures and three market structures.Our findings show that in the monopoly market structure suppliers are motivated for profit to own platform if the density of suppliers is more than 1.0457. The ownership is not socially preferable and government should intervene in markets. Duopoly market structure has single-homing and multi-homing forms. Three cases were compared with each other: (1) two competing platforms owned by independent third parties, (2) one common platform jointly owned by two different suppliers, (3) one platform owned by an independent third party and the other co-owned by suppliers. Our analysis results show that independent third party ownership is a socially optimal ownership structure. Supplier-ownership should be regulated in order to maximize social welfare. Interactions between two platform ownership

  12. Space biology initiative program definition review. Trade study 5: Modification of existing hardware (COTS) versus new hardware build cost analysis

    Science.gov (United States)

    Jackson, L. Neal; Crenshaw, John, Sr.; Davidson, William L.; Blacknall, Carolyn; Bilodeau, James W.; Stoval, J. Michael; Sutton, Terry

    1989-01-01

    The JSC Life Sciences Project Division has been directly supporting NASA Headquarters, Life Sciences Division, in the preparation of data from JSC and ARC to assist in defining the Space Biology Initiative (SBI). GE Government Services and Horizon Aerospace have provided contract support for the development and integration of review data, reports, presentations, and detailed supporting data. An SBI Definition (Non-Advocate) Review at NASA Headquarters, Code B, has been scheduled for the June-July 1989 time period. In a previous NASA Headquarters review, NASA determined that additional supporting data would be beneficial to determine the potential advantages in modifying commercial off-the-shelf (COTS) hardware for some SBI hardware items. In order to meet the demands of program implementation planning with the definition review in late spring of 1989, the definition trade study analysis must be adjusted in scope and schedule to be complete for the SBI Definition (Non-Advocate) Review. The relative costs of modifying existing commercial off-the-shelf (COTS) hardware is compared to fabricating new hardware. An historical basis for new build versus modifying COTS to meet current NMI specifications for manned space flight hardware is surveyed and identified. Selected SBI hardware are identified as potential candidates for off-the-shelf modification and statistical estimates on the relative cost of modifying COTS versus new build are provided.

  13. Bringing Definitions into High Definition

    Science.gov (United States)

    Mason, John

    2010-01-01

    Why do definitions play such a central role in mathematics? It may seem obvious that precision about the terms one uses is necessary in order to use those terms reasonably (while reasoning). Definitions are chosen so as to be definite about the terms one uses, but also to make both the statement of, and the reasoning to justify, theorems as…

  14. Definition of Successful Aging by Elderly Canadian Males: The Manitoba Follow-Up Study

    Science.gov (United States)

    Tate, Robert B.; Lah, Leedine; Cuddy, T. Edward

    2003-01-01

    Purpose: Although the concept of successful aging is used widely in the field of gerontology, there is no agreed-on standard or common underlying definition for measuring success in aging. Our recent survey of an elderly male population asked respondents to define "successful aging." This paper describes the themes that evolved from…

  15. Gaining Insights on the H2–Sorbent Interactions: Robust soc-MOF Platform as a Case Study

    KAUST Repository

    Cairns, Amy J.

    2016-09-18

    We report on the synthesis and gas adsorption properties (i.e., Ar and H2) of four robust 3-periodic metal–organic frameworks (MOFs) having the targeted soc topology. These cationic MOFs are isostructural to the parent indium-based MOF, In-soc-MOF-1a (for NO3–), previously reported by us, and likewise are constructed from the assembly of rigid μ3-oxygen-centered trinuclear metal carboxylate clusters, [M3O(O2C−)6], where M = In3+ or Fe3+. Each inorganic trinuclear molecular building block (MBB), generated in situ, is bridged by six 3,3′,5,5′-azobenzenetetracarboxylate (ABTC4–) ligands to give the extended (4,6)-connected MOF, soc-MOF. In our previous work, we confirmed that the parent soc-MOF, i.e., In-soc-MOF-1a, possesses unique structural characteristics (e.g., vacant In binding sites and narrow pores with higher localized charge density), which led to exceptional hydrogen (H2) storage capabilities. Therefore, charged MOFs with soc topology can be viewed collectively as an ideal prototypical platform to examine the impact of specific structural parameters on H2–MOF interactions via systematic gas adsorption studies. We infer that enhanced binding of molecular H2 is primarily governed by the presence and type of vacant metal centers (i.e., Fe was shown to exhibit stronger H2–MOF interactions at low H2 loading compared to the In analogues). These findings are evident from the associated isosteric heat of adsorption (Qst) at low loadings and inelastic neutron scattering (INS) experiments of the rotational transitions of sorbed H2, as well as, temperature-programmed desorption (TPD) studies (for a select compound). The importance of localized charge density is also highlighted, where the extra-framework nitrate anions in the Fe-soc-MOF-1a (for NO3–) facilitate enhanced binding affinities as compared to the chloride analogue.

  16. New data on facies development and micropaleontology of the eastern margin of the Getic Carbonate Platform (South Carpathians, Romania: case study of Mateiaş Limestone

    Directory of Open Access Journals (Sweden)

    Ioan I. Bucur

    2010-08-01

    Full Text Available Mateiaş Limestone represents a lithostratigraphic unit included in the Braşov Series, which is a component of the eastern end of the Getic Nappes’ cover (the Getic carbonate platform. The study of the Mateiaş Limestone in Hulei-Mateiaş-Măgura area has evidenced three main facies, and five microfacies types. The Kimmeridgian (possibly also Early Tithonian age of the Mateiaş Limestone has been assigned based on a microfossil association identified in thin sections. The regional framework, as well as their sedimentological and micropaleontological features point to the deposition of these limestones on shelf margin and slope environments; the succession in the studied area corresponds to the lower-median part of the carbonate deposits developed in more internally eastern parts of the Getic carbonate platform.

  17. A field study of data analysis exercises in a bachelor physics course using the internet platform VISPA

    Science.gov (United States)

    Erdmann, Martin; Fischer, Robert; Glaser, Christian; Klingebiel, Dennis; Krause, Raphael; Kuempel, Daniel; Müller, Gero; Rieger, Marcel; Steggemann, Jan; Urban, Martin; Walz, David; Weidenhaupt, Klaus; Winchen, Tobias; Weltermann, Birgitta

    2014-05-01

    Bachelor of physics lectures on ‘Particle Physics and Astrophysics’ were complemented by exercises related to data analysis and data interpretation at the RWTH Aachen University recently. The students performed these exercises using the internet platform VISPA, which provides a development environment for physics data analyses. We describe the platform and its application within the physics course, and present the results of a student survey. The students’ acceptance of the learning project was positive. The level of acceptance was related to their individual preference for learning with a computer. Furthermore, students with good programming skills favour working individually, while students who attribute themselves as having low programming abilities favour working in teams. The students appreciated approaching actual research through the data analysis tasks.

  18. A field study of data analysis exercises in a bachelor physics course using the internet platform VISPA

    CERN Document Server

    Erdmann, Martin; Glaser, Christian; Klingebiel, Dennis; Krause, Raphael; Kuempel, Daniel; Mueller, Gero; Rieger, Marcel; Steggemann, Jan; Urban, Martin; Walz, David; Weidenhaupt, Klaus; Winchen, Tobias; Weltermann, Birgitta

    2014-01-01

    Bachelor physics lectures on particle physics and astrophysics were complemented by exercises related to data analysis and data interpretation at the RWTH Aachen University recently. The students performed these exercises using the internet platform VISPA, which provides a development environment for physics data analyses. We describe the platform and its application within the physics course, and present the results of a student survey. The students acceptance of the learning project was positive. The level of acceptance was related to their individual preference for learning with a computer. Furthermore, students with good programming skills favor working individually, while students who attribute themselves having low programming abilities favor working in teams. The students appreciated approaching actual research through the data analysis tasks.

  19. ITS Platform North Denmark

    DEFF Research Database (Denmark)

    Lahrmann, Harry; Agerholm, Niels; Juhl, Jens

    2012-01-01

    This paper presents the project entitled “ITS Platform North Denmark” which is used as a test platform for Intelligent Transportation System (ITS) solutions. The platform consists of a newly developed GNSS/GPRS On Board Unit (OBU) to be installed in 500 cars, a backend server and a specially...... designed digital road map for ITS applications. The platform is freely accessible, which means that third party applications could be run on the platform. It is estimated that using this platform enables the ITS applications to be developed for 20% of the normal cost, hence third party are invited to test...... their applications in this platform. This paper presents the platform’s potentials and explains a series of test applications which are under development on it. Moreover, a number of new projects planned for the platform are demonstrated....

  20. Definitely Life but not Definitively

    Science.gov (United States)

    Oliver, Joan D.; Perry, Randall S.

    2006-12-01

    Although there have been attempts at a definition of life from many disciplines, none is accepted by all as definitive. Some people believe that it is impossible to define ‘life’ adequately at the moment. We agree with this point of view on linguistic grounds, examining the different types of definition, the contexts in which they are used and their relative usefulness as aids to arriving at a scientific definition of life. We look at some of the more recent definitions and analyse them in the light of our criteria for a good definition. We argue that since there are so many linguistic and philosophical difficulties with such a definition of life, what is needed is a series of working descriptions, which are suited to the audience and context in which they are used and useful for the intended purpose. We provide some ideas and examples of the forms these may take.

  1. Design Thinking and Cloud Manufacturing: A Study of Cloud Model Sharing Platform Based on Separated Data Log

    OpenAIRE

    Zhe Wei; Yixiong Feng; Xiaoyi Wang; Zuowen Sun; Yong Sun

    2013-01-01

    To solve the product data consistency problem which is caused by the portable system that cannot conduct real-time update of product data in mobile environment under the mass customization production mode, a new product data optimistic replication method based on log is presented. This paper focuses on the design thinking provider, probing into a manufacturing resource design thinking cloud platform based on manufacturing resource-locating technologies, and also discuss several application sc...

  2. Study on Data Platform Standards System%数据平台标准体系研究

    Institute of Scientific and Technical Information of China (English)

    张正敏; 朱婕

    2016-01-01

    In recent years, the role of data has reached an unprecedented height for the government and enterprises, so the investment of data platform construction is also growing. In order to promote the standardization level of relevant data platform of government and public institutions and promote the role of public information in the construction of social credit system, this paper takes reference of the OPC series standard design concept, puts forward a data platform standards system according to the relevant national policies and regulations, analyzes the related technical requirements of data exchange and security, which makes a useful exploration for enhancing the standardization level of China's data platform construction and application.%近年来,政府和企业对于数据作用的认识达到了前所未有的高度,数据平台建设的投入也越来越大。为提升政府、事业单位相关部门数据平台的标准化水平,促进公共信息在社会诚信体系建设中的作用,本文在借鉴OPC系列标准设计理念的基础上,按照国家相关政策法规的要求,提出了数据平台标准体系,重点分析了数据在交换和安全方面的技术要求,为我国数据平台的建设和应用标准化水平提升做出了有益的探索。

  3. An accuracy assessment of the CALIOP/CALIPSO version 2 aerosol extinction product based on a detailed multi-sensor, multi-platform case study

    OpenAIRE

    Kacenelenbogen, M.; VAUGHAN, M.A.; Redemann, J.; Hoff, R. M.; R. R. Rogers; Ferrare, R. A.; P. B. Russell; Hostetler, C. A.; J. W. Hair; Holben, B.N.

    2010-01-01

    The Cloud Aerosol LIdar with Orthogonal Polarization (CALIOP), on board the CALIPSO platform, has measured profiles of total attenuated backscatter coefficient (level 1 products) since June 2006. CALIOP's level 2 products, such as the aerosol backscatter and extinction coefficient profiles, are retrieved using a complex succession of automated algorithms. The goal of this study is to help identify potential shortcomings in the CALIOP version 2 level 2 aerosol extinction product and to il...

  4. 大学生创业平台的构建%Study on the construction of undergraduate entrepreneurship platform

    Institute of Scientific and Technical Information of China (English)

    郑秋; 黄辉; 田军鹏

    2012-01-01

      创业是这个时代经济增长的重要推动力,也是解决社会就业矛盾的一个重要途径。构建大学生创业平台是高校培养人才和体现社会服务职能的重要体现。本文分析了目前大学生创业实践中存在的若干问题,指出创业平台构建的重大意义,并提出了构建大学生创业教育平台的几个做法。%  Entrepreneurship is the driving force of economic growth, and is an important way to solve the problems about the social employment. The construction of entrepreneurship platform is the further manifestation of social service function in colleges and universities, and is reform of high education. This paper analyzed the problems of undergraduate entrepreneurship in practice, pointed out the significance of the entrepreneurship platform, and summarized a few questions need to be answered in the construction of entrepreneurship platform in practice.

  5. Study on the Definition of Police Assistants%辅警定义研究

    Institute of Scientific and Technical Information of China (English)

    林海文; 王世卿

    2012-01-01

      The evolution of police assistants is a miniature of good governance executed by Chinese government, the study of which is related not only with economic factors but with political ones and has rich and profound policing, social and political connotation. However, to set up confidence in the study on the police assistants it is necessary to know the status of the study on police assistants theoretical foundation and its clear definition. At this stage, the police assistants show the unique attributes of society, the public and police. As such, it can be deduced that in the broad sense the police assistants refer to the force which is organized by the government agencies, markets or other organs to participate in policing or voluntary activities in order to attain the policing related goal of the public, social groups and some individuals. In the narrow sense, the police assistants refer to the public voluntary social force which is organized, used, purchased or employed by the government or functional departments.%  辅警的发展是中国政府施行良政的一个缩影,关于它的研究既涉及经济因素又有政治方面的考量,蕴含着丰富且深刻的警务、社会乃至政治内涵。然而,要为辅警深入研究奠定信心,必须掌握辅警理论的学科地位、理论基础以及深刻清晰的界定。社会性、群众性、警事性是我国现阶段辅警所呈现的特有属性,由此可以推出:广义辅警是指为实现国家公共的、部分利益团体的以及个人的警事目的,由政府部门、市场或者第三部门所组织起来的共同参与警事活动的力量;狭义辅警应当是指为实现警务效能,通过制度直接组织管理使用的,为政府或者职能部门购买、聘用或宣传发动起来志愿的社会群众力量。

  6. Mobile platform security

    CERN Document Server

    Asokan, N; Dmitrienko, Alexandra

    2013-01-01

    Recently, mobile security has garnered considerable interest in both the research community and industry due to the popularity of smartphones. The current smartphone platforms are open systems that allow application development, also for malicious parties. To protect the mobile device, its user, and other mobile ecosystem stakeholders such as network operators, application execution is controlled by a platform security architecture. This book explores how such mobile platform security architectures work. We present a generic model for mobile platform security architectures: the model illustrat

  7. Biological system development for GraviSat: A new platform for studying photosynthesis and microalgae in space

    Science.gov (United States)

    Fleming, Erich D.; Bebout, Brad M.; Tan, Ming X.; Selch, Florian; Ricco, Antonio J.

    2014-10-01

    microwells that did not include dissolved bicarbonate due to CO2 starvation. Additionally, oxygen production by some microalgae resulted in bubble formation within the wells, which interfered with sensor measurements. Our research achieved prolonged growth periods (>10 months) without excess oxygen production using two microalgal strains, Chlorella vulgaris UTEX 29 and Dunaliella bardawil 30 861, by lowering light intensities (2-10 μmol photons m-2 s-1) and temperature (4-12 °C). Although the experiments described here were performed to develop the GraviSat platform, the results of this study should be useful for the incorporation of microalgae in other satellite payloads with low-volume microfluidic systems.

  8. Model-driven product line engineering for mapping parallel algorithms to parallel computing platforms

    NARCIS (Netherlands)

    Arkin, Ethem; Tekinerdogan, Bedir

    2016-01-01

    Mapping parallel algorithms to parallel computing platforms requires several activities such as the analysis of the parallel algorithm, the definition of the logical configuration of the platform, the mapping of the algorithm to the logical configuration platform and the implementation of the sou

  9. Systematic review and meta-analysis of validation studies on a diabetes case definition from health administrative records.

    Directory of Open Access Journals (Sweden)

    Aaron Leong

    Full Text Available OBJECTIVES: Health administrative data are frequently used for diabetes surveillance. We aimed to determine the sensitivity and specificity of a commonly-used diabetes case definition (two physician claims or one hospital discharge abstract record within a two-year period and their potential effect on prevalence estimation. METHODS: Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA guidelines, we searched Medline (from 1950 and Embase (from 1980 databases for validation studies through August 2012 (keywords: "diabetes mellitus"; "administrative databases"; "validation studies". Reviewers abstracted data with standardized forms and assessed quality using Quality Assessment of Diagnostic Accuracy Studies (QUADAS criteria. A generalized linear model approach to random-effects bivariate regression meta-analysis was used to pool sensitivity and specificity estimates. We applied correction factors derived from pooled sensitivity and specificity estimates to prevalence estimates from national surveillance reports and projected prevalence estimates over 10 years (to 2018. RESULTS: The search strategy identified 1423 abstracts among which 11 studies were deemed relevant and reviewed; 6 of these reported sensitivity and specificity allowing pooling in a meta-analysis. Compared to surveys or medical records, sensitivity was 82.3% (95%CI 75.8, 87.4 and specificity was 97.9% (95%CI 96.5, 98.8. The diabetes case definition underestimated prevalence when it was ≤10.6% and overestimated prevalence otherwise. CONCLUSION: The diabetes case definition examined misses up to one fifth of diabetes cases and wrongly identifies diabetes in approximately 2% of the population. This may be sufficiently sensitive and specific for surveillance purposes, in particular monitoring prevalence trends. Applying correction factors to adjust prevalence estimates from this definition may be helpful to increase accuracy of estimates.

  10. Identifying Topics for E-Cigarette User-Generated Contents: A Case Study From Multiple Social Media Platforms

    Science.gov (United States)

    Zhan, Yongcheng; Liu, Ruoran; Li, Qiudan; Leischow, Scott James

    2017-01-01

    Background Electronic cigarette (e-cigarette) is an emerging product with a rapid-growth market in recent years. Social media has become an important platform for information seeking and sharing. We aim to mine hidden topics from e-cigarette datasets collected from different social media platforms. Objective This paper aims to gain a systematic understanding of the characteristics of various types of social media, which will provide deep insights into how consumers and policy makers effectively use social media to track e-cigarette-related content and adjust their decisions and policies. Methods We collected data from Reddit (27,638 e-cigarette flavor-related posts from January 1, 2011, to June 30, 2015), JuiceDB (14,433 e-juice reviews from June 26, 2013 to November 12, 2015), and Twitter (13,356 “e-cig ban”-related tweets from January, 1, 2010 to June 30, 2015). Latent Dirichlet Allocation, a generative model for topic modeling, was used to analyze the topics from these data. Results We found four types of topics across the platforms: (1) promotions, (2) flavor discussions, (3) experience sharing, and (4) regulation debates. Promotions included sales from vendors to users, as well as trades among users. A total of 10.72% (2,962/27,638) of the posts from Reddit were related to trading. Promotion links were found between social media platforms. Most of the links (87.30%) in JuiceDB were related to Reddit posts. JuiceDB and Reddit identified consistent flavor categories. E-cigarette vaping methods and features such as steeping, throat hit, and vapor production were broadly discussed both on Reddit and on JuiceDB. Reddit provided space for policy discussions and majority of the posts (60.7%) holding a negative attitude toward regulations, whereas Twitter was used to launch campaigns using certain hashtags. Our findings are based on data across different platforms. The topic distribution between Reddit and JuiceDB was significantly different (Pmined findings could

  11. Identifying Topics for E-Cigarette User-Generated Contents: A Case Study From Multiple Social Media Platforms.

    Science.gov (United States)

    Zhan, Yongcheng; Liu, Ruoran; Li, Qiudan; Leischow, Scott James; Zeng, Daniel Dajun

    2017-01-20

    Electronic cigarette (e-cigarette) is an emerging product with a rapid-growth market in recent years. Social media has become an important platform for information seeking and sharing. We aim to mine hidden topics from e-cigarette datasets collected from different social media platforms. This paper aims to gain a systematic understanding of the characteristics of various types of social media, which will provide deep insights into how consumers and policy makers effectively use social media to track e-cigarette-related content and adjust their decisions and policies. We collected data from Reddit (27,638 e-cigarette flavor-related posts from January 1, 2011, to June 30, 2015), JuiceDB (14,433 e-juice reviews from June 26, 2013 to November 12, 2015), and Twitter (13,356 "e-cig ban"-related tweets from January, 1, 2010 to June 30, 2015). Latent Dirichlet Allocation, a generative model for topic modeling, was used to analyze the topics from these data. We found four types of topics across the platforms: (1) promotions, (2) flavor discussions, (3) experience sharing, and (4) regulation debates. Promotions included sales from vendors to users, as well as trades among users. A total of 10.72% (2,962/27,638) of the posts from Reddit were related to trading. Promotion links were found between social media platforms. Most of the links (87.30%) in JuiceDB were related to Reddit posts. JuiceDB and Reddit identified consistent flavor categories. E-cigarette vaping methods and features such as steeping, throat hit, and vapor production were broadly discussed both on Reddit and on JuiceDB. Reddit provided space for policy discussions and majority of the posts (60.7%) holding a negative attitude toward regulations, whereas Twitter was used to launch campaigns using certain hashtags. Our findings are based on data across different platforms. The topic distribution between Reddit and JuiceDB was significantly different (Psocial media data sources for e-cigarette research. These

  12. Towards a Framework of Digital Platform Disruption

    DEFF Research Database (Denmark)

    Kazan, Erol; Tan, Chee-Wee; Lim, Eric T. K.

    2014-01-01

    Digital platforms are disruptive information technology (IT) artifacts that erode conventional business logic associated with traditional market structures. This paper presents a framework for examining the disruptive potential of digital platforms whereby we postulate that the strategic interplay...... of governance regimes and platform layers is deterministic of whether disruptive derivatives are permitted to flourish. This framework has been employed in a comparative case study between centralized (i.e., PayPal) and decentralized (i.e., Coinkite) digital payment platforms to illustrate its applicability...... and yield propositions on the nature and impact of digital platform disruptions. Preliminary findings indicate that centralized digital platforms attempt to create unique configurals to obtain monopolistic power by tightly coupling platform layers, which are difficult to replicate. Conversely, decentralized...

  13. Demand forecasting and information platform in tourism

    Science.gov (United States)

    Li, Yue; Jiang, Qi-Jie

    2017-05-01

    Information asymmetry and the bullwhip effect have been serious problems in the tourism supply chain. Based on platform theory, this paper established a mathematical model to explore the inner mechanism of a platform's influence on stakeholders' ability to forecast demand in tourism. Results showed that the variance of stakeholders' demand predictions with a platform was smaller than the variance without a platform, which meant that a platform would improve predictions of demand for stakeholders. The higher information-processing ability of the platform also had other effects on demand forecasting. Research on the inner logic of the platform's influence on stakeholders has important theoretical and realistic value. This area is worthy of further study.

  14. What is the best tool for transanal endoscopic microsurgery (TEM)? A case-matched study in 74 patients comparing a standard platform and a disposable material.

    Science.gov (United States)

    Mege, Diane; Bridoux, Valérie; Maggiori, Léon; Tuech, Jean-Jacques; Panis, Yves

    2017-07-01

    Transanal endoscopic microsurgery (TEM) is the gold standard for local excision of rectal lesions, but no study exists concerning the best material. The objective was to compare TEM using a disposable material vs a standard platform through a case-matched study. Patients who underwent TEM for rectal neoplasms were identified from prospective databases in two tertiary referral centers and matched according to four criteria (sex, tumor location, size, distance from the anal verge): TEM using a disposable material (GelPoint Applied®; group A) and TEM using a standard TEO® platform (Karl Storz, Tuttlingen, Germany; group B). A total of 74 patients were included and divided into group A (n = 33) and group B (n = 41). Full-thickness resection was less frequent in group A (85%) than B (100%; p = 0.01). Adenocarcinoma was less frequent in group A than B: 27 vs 42% (p = 0.03). No difference was noted regarding median operative time (53 vs 53 min; p = 0.6) and a peritoneal perforation rate (6 vs 20%; p = 0.17). Median length of stay was shorter in group A than B (4 vs 5 days; p study suggested that TEM can be performed using either a TEO® platform or a disposable material, with similar surgical results. The TEO® platform seems to be superior to obtain full-thickness and R0 resection.

  15. Apache The Definitive Guide

    CERN Document Server

    Laurie, Ben

    2003-01-01

    Apache is far and away the most widely used web server platform in the world. This versatile server runs more than half of the world's existing web sites. Apache is both free and rock-solid, running more than 21 million web sites ranging from huge e-commerce operations to corporate intranets and smaller hobby sites. With this new third edition of Apache: The Definitive Guide, web administrators new to Apache will come up to speed quickly, and experienced administrators will find the logically organized, concise reference sections indispensable, and system programmers interested in customizin

  16. AutoCAD platform customization VBA

    CERN Document Server

    Ambrosius, Lee

    2015-01-01

    Boost productivity and streamline your workflow with expert AutoCAD: VBA programming instruction AutoCAD Platform Customization: VBA is the definitive guide to personalizing AutoCAD and the various programs that run on the AutoCAD platform, including AutoCAD Architecture, Civil 3D, Plant 3D, and more. Written by an Autodesk insider with years of customization and programming experience, this book features detailed discussions backed by real-world examples and easy-to-follow tutorials that illustrate each step in the personalization process. Readers gain expert guidance toward managing layout

  17. The Australian Multiple Sclerosis (MS immunotherapy study: a prospective, multicentre study of drug utilisation using the MSBase platform.

    Directory of Open Access Journals (Sweden)

    Vilija G Jokubaitis

    Full Text Available OBJECTIVE: To prospectively characterise treatment persistence and predictors of treatment discontinuation in an Australian relapsing-remitting multiple sclerosis (RRMS population. METHODS: Tertiary MS treatment centres participating in the MSBase registry prospectively assessed treatment utilisation, persistence, predictors of treatment discontinuation and switch rates. Multivariable survival analyses were used to compare treatment persistence between drugs and to identify predictors of treatment discontinuation. RESULTS: 1113 RRMS patients were studied. Patients persisted on their first disease-modifying therapy (DMT for a median of 2.5 years. Treatment persistence on GA was shorter than on all IFNβ products (p<0.03. Younger age at treatment initiation and higher EDSS were predictive of DMT discontinuation. Patients persisted on subsequent DMTs, for 2.3 years. Patients receiving natalizumab (NAT as a subsequent DMT persisted longer on treatment than those on IFNβ or GA (p<0.000. The primary reason for treatment discontinuation for any drug class was poor tolerability. Annualised switch or cessation rates were 9.5-12.5% for individual IFNβ products, 11.6% for GA and 4.4% for NAT. CONCLUSION: This multicentre MS cohort study is the first to directly compare treatment persistence on IFNβ and GA to NAT. We report that treatment persistence in our Australian RRMS population is short, although patients receiving IFNβ as a first DMT persisted longer on treatment than those on GA. Additionally, patients receiving NAT as a subsequent DMT were more likely to persist on treatment than those switched to IFNβ or GA. EDSS and age at DMT initiation were predictive of DMT discontinuation. Treatment intolerance was the principal reason for treatment cessation.

  18. Engineering Definitional Interpreters

    DEFF Research Database (Denmark)

    Midtgaard, Jan; Ramsay, Norman; Larsen, Bradford

    2013-01-01

    A definitional interpreter should be clear and easy to write, but it may run 4--10 times slower than a well-crafted bytecode interpreter. In a case study focused on implementation choices, we explore ways of making definitional interpreters faster without expending much programming effort. We imp...

  19. Engineering Definitional Interpreters

    DEFF Research Database (Denmark)

    Midtgaard, Jan; Ramsay, Norman; Larsen, Bradford

    2013-01-01

    A definitional interpreter should be clear and easy to write, but it may run 4--10 times slower than a well-crafted bytecode interpreter. In a case study focused on implementation choices, we explore ways of making definitional interpreters faster without expending much programming effort. We imp...

  20. Study on Logistics Information Exchange Platform Based on XML%基于XML的物流信息交换平台研究

    Institute of Scientific and Technical Information of China (English)

    张昌杰

    2013-01-01

    研究了基于XML技术的物流信息交换平台,以实现物流企业的电子文件的自动内容收集、数据储存、传输、处理,以及数据呈现等,讨论了物流信息交换平台下两个主要的接口程序:网页接口及应用系统接口.%In this paper, we studied the logistics information exchange platform based on XML technology to realize the automatic content collection, data storage, transmission, processing and presentation, etc., and discussed the two major interface programmes of the platform: web-page interface and app system interface.

  1. Transparent conducting oxide electro-optic modulators on silicon platforms: A comprehensive study based on the drift-diffusion semiconductor model

    Science.gov (United States)

    Sinatkas, Georgios; Pitilakis, Alexandros; Zografopoulos, Dimitrios C.; Beccherelli, Romeo; Kriezis, Emmanouil E.

    2017-01-01

    Electro-optic waveguide modulators exploiting the carrier-induced epsilon-near-zero effect in transparent conducting oxides are comprehensively studied and evaluated using a rigorous multi-physics modeling framework. The examined amplitude modulators integrate indium tin oxide with two representative examples of the silicon-on-insulator technology, the silicon-rib and silicon-slot platform, with the latter design exhibiting superior performance, featuring μm modulation lengths, switching speeds exceeding 100 GHz, and a sub-pJ per bit of energy consumption. The effect of free carriers is rigorously introduced by combining the drift-diffusion model for the description of the carrier dynamics with near-infrared carrier-dependent permittivity models, leading to a seamless and physically consistent integration of solid-state physics and Maxwell wave theory on a unified finite-element platform.

  2. Interrater reliability of the international consensus definition of drug-resistant epilepsy: a pilot study.

    Science.gov (United States)

    Hao, Xiao-ting; Wong, Irina S M; Kwan, Patrick

    2011-10-01

    We evaluated the interrater reliability of the consensus definition of drug-resistant epilepsy proposed by the International League Against Epilepsy. According to the definition framework, outcome of each antiepileptic drug (AED) trial was categorized as "seizure freedom" or "treatment failure." This level 1 assessment was used to determine the level 2 classification, which defined drug-resistant epilepsy as the failure of adequate trials of two or more AED schedules to achieve sustained seizure freedom. Two raters classified treatment outcomes of 150 patients independently. The patients had received a total of 428 trials of AEDs. Categorization of level 1 outcome to individual AED trials by the raters was consistent in 413 (96.5%). For the level 2 classification of drug-resistant or drug-responsive epilepsy, there was absolute agreement between the raters in 141 patients (94%), with a κ index of 0.91 (Pdefinition appeared to have a high degree of interrater reliability in this setting.

  3. Satellite power systems (SPS) concept definition study. Volume 7: SPS program plan and economic analysis, appendixes

    Science.gov (United States)

    Hanley, G.

    1978-01-01

    Three appendixes in support of Volume 7 are contained in this document. The three appendixes are: (1) Satellite Power System Work Breakdown Structure Dictionary; (2) SPS cost Estimating Relationships; and (3) Financial and Operational Concept. Other volumes of the final report that provide additional detail are: Executive Summary; SPS Systems Requirements; SPS Concept Evolution; SPS Point Design Definition; Transportation and Operations Analysis; and SPS Technology Requirements and Verification.

  4. Magnetometer instrument team studies for the definition phase of the outer planets grand tour

    Science.gov (United States)

    Coleman, P. J., Jr.

    1973-01-01

    The work performed by the magnetic fields investigation team during the mission definition phases of the Outer Planets Grand Tour (OPGT) and the Mariner Jupiter Saturn (MJS) Missions is reported. This work involved three tasks: (1) defining the objectives of the magnetic fields investigations, (2) defining the magnetometer systems required to meet these objectives, and (3) developing and testing hardware elements in certain mission-specific areas.

  5. Continuous Platform Development

    DEFF Research Database (Denmark)

    Nielsen, Ole Fiil

    low risks and investments but also with relatively fuzzy results. When looking for new platform projects, it is important to make sure that the company and market is ready for the introduction of platforms, and to make sure that people from marketing and sales, product development, and downstream......, but continuous product family evolution challenges this strategy. The concept of continuous platform development is based on the fact that platform development should not be a one-time experience but rather an ongoing process of developing new platforms and updating existing ones, so that product family...

  6. On some positive definite functions

    OpenAIRE

    Bhatia, Rajendra; Jain, Tanvi

    2014-01-01

    We study the function $(1 - \\|x\\|)\\slash (1 - \\|x\\|^r),$ and its reciprocal, on the Euclidean space $\\mathbb{R}^n,$ with respect to properties like being positive definite, conditionally positive definite, and infinitely divisible.

  7. Definitions of Health Terms: Nutrition

    Science.gov (United States)

    ... gov/definitions/nutritiondefinitions.html Definitions of Health Terms: Nutrition To use the sharing features on this page, ... National Institutes of Health, Office of Dietary Supplements Nutrition This field of study focuses on foods and ...

  8. Time to definitive diagnosis of breast cancer in Latina and non-Hispanic white women: the six cities study.

    Science.gov (United States)

    Ramirez, Amelie G; Pérez-Stable, Eliseo J; Talavera, Gregory A; Penedo, Frank J; Carrillo, J Emilio; Fernandez, Maria E; Muñoz, Edgar; Long Parma, Dorothy; Holden, Alan Ec; San Miguel de Majors, Sandra; Nápoles, Anna; Castañeda, Sheila F; Gallion, Kipling J

    2013-12-01

    Time delay after an abnormal screening mammogram may have a critical impact on tumor size, stage at diagnosis, treatment, prognosis, and survival of subsequent breast cancer. This study was undertaken to evaluate disparities between Latina and non-Hispanic white (NHW) women in time to definitive diagnosis of breast cancer after an abnormal screening mammogram, as well as factors contributing to such disparities. As part of the activities of the National Cancer Institute (NCI)-funded Redes En Acción research network, clinical records of 186 Latinas and 74 NHWs who received abnormal screening mammogram results were reviewed to determine the time to obtain a definitive diagnosis. Data was obtained from participating clinics in six U.S. cities and included demographics, clinical history, and mammogram characteristics. Kaplan-Meier estimates and Cox proportional hazards models were used to test differences in median time to definitive diagnosis by ethnicity after adjusting for clinic site, demographics, and clinical characteristics. Time-to-event analysis showed that Latinas took 2.2 times longer to reach 50% definitively diagnosed with breast cancer relative to NHWs, and three times longer to reach 80% diagnosed (p=0.001). Latinas' median time to definitive diagnosis was 60 days compared to 27 for NHWs, a 59% gap in diagnosis rates (adjusted Hazard Ratio [aHR] = 1.59, 95% CI = 1.09, 2.31; p=0.015). BI-RADS-4/5 women's diagnosis rate was more than twice that of BI-RADS-3 (aHR = 2.11, 95% CI = 1.18, 3.78; p=0.011). Disparities in time between receipt of abnormal screening result and definitive diagnosis adversely affect Latinas compared to NHWs, and remain significant after adjusting for demographic and clinical variables. With cancer now the leading cause of mortality among Latinos, a greater need exists for ethnically and culturally appropriate interventions like patient navigation to facilitate Latinas' successful entry into, and progression through, the cancer care

  9. Materials Data Infrastructure: A Case Study of the Citrination Platform to Examine Data Import, Storage, and Access

    Science.gov (United States)

    O'Mara, Jordan; Meredig, Bryce; Michel, Kyle

    2016-08-01

    Considerations are presented around the design of a materials data infrastructure including import of structured and unstructured data, storage of that data for archival and retrieval, and access to that data through programmatic and graphical interfaces. In particular, the choices around technologies used in such an infrastructure, the benefits and drawbacks of those technologies, and their impact on the experience of users of that system are presented. The Citrination platform is used as an example of a materials data infrastructure and the choices made around architecture are discussed.

  10. CONFIGURATION DEVELOPMENT ON THE PLATFORM 1C FOR ENTERPRISE AUTOMATION

    OpenAIRE

    О.L. LIAKHOV; T.A. DMYTRENKO; A.О. TVERDOKHLIB; T.M. DERKACH; A.O. DMYTRENKO

    2015-01-01

    In this paper, the results of configuration development on the platform 1C for limited liability companies were presented. The object of study is the development process configuration platform 1C. The purpose of the study is the technological platform “1C: Enterprise”. The tasks included analyzing the technological platform “1C: Enterprise”, comparing the most popular ERP-systems, configurator devel-opment on the platform 1C. Such research methods as structured programming techniques and meth...

  11. Developing Knowledge-Based Citizen Participation Platform to Support Smart City Decision Making: The Smarticipate Case Study

    Directory of Open Access Journals (Sweden)

    Zaheer Khan

    2017-04-01

    Full Text Available Citizen participation for social innovation and co-creating urban regeneration proposals can be greatly facilitated by innovative IT systems. Such systems can use Open Government Data, visualise urban proposals in 3D models and provide automated feedback on the feasibility of the proposals. Using such a system as a communication platform between citizens and city administrations provides an integrated top-down and bottom-up urban planning and decision-making approach to smart cities. However, generating automated feedback on citizens’ proposals requires modelling domain-specific knowledge i.e., vocabulary and rules, which can be applied on spatial and temporal 3D models. This paper presents the European Commission funded H2020 smarticipate project that aims to achieve the above challenge by applying it on three smart cities: Hamburg, Rome and RBKC-London. Whilst the proposed system architecture indicates various innovative features, a proof of concept of the automated feedback feature for the Hamburg use case ‘planting trees’ is demonstrated. Early results and lessons learned show that it is feasible to provide automated feedback on citizen-initiated proposals on specific topics. However, it is not straightforward to generalise this feature to cover more complex concepts and conditions which require specifying comprehensive domain languages, rules and appropriate tools to process them. This paper also highlights the strengths of the smarticipate platform, discusses challenges to realise its different features and suggests potential solutions.

  12. Time-Dependant Responses of High-Definition Induction Log and Case Studies

    Directory of Open Access Journals (Sweden)

    Jianhua Zhang

    2014-01-01

    Full Text Available The process of drilling mud filtrate invading into a reservoir is time dependant. It causes dynamic invasion profiles of formation parameters such as water saturation, salinity, and formation resistivity. Thus, the responses of a high-definition induction log (HDIL tool are time dependent. The logging time should be considered as an important parameter during logging interpretation for the purposes of determining true formation resistivity, estimating initial water saturation, and evaluating a reservoir. The time-dependent HDIL responses are helpful for log analysts to understand the invasion process physically. Field examples were illustrated for the application of present method.

  13. Competing definitions of schizophrenia: what can be learned from polydiagnostic studies?

    DEFF Research Database (Denmark)

    Jansson, Lennart B; Parnas, Josef

    2007-01-01

    The contemporary diagnoses of schizophrenia (sz)-Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition(DSM-IV) and International Classification of Diseases, 10th Revision(ICD-10)-are widely considered as important scientific achievements. However, these algorithms were not a product....... The DSM-IV and the ICD-10 show moderate reliability but both definitions appear weak in terms of concurrent validity, eg, with respect to an aggregation of a priori important features. The first-rank symptoms of Schneider are not associated with family history of sz or with prediction of poor outcome...

  14. Cots Correlator Platform

    Science.gov (United States)

    Schaaf, Kjeld; Overeem, Ruud

    2004-06-01

    Moore’s law is best exploited by using consumer market hardware. In particular, the gaming industry pushes the limit of processor performance thus reducing the cost per raw flop even faster than Moore’s law predicts. Next to the cost benefits of Common-Of-The-Shelf (COTS) processing resources, there is a rapidly growing experience pool in cluster based processing. The typical Beowulf cluster of PC’s supercomputers are well known. Multiple examples exists of specialised cluster computers based on more advanced server nodes or even gaming stations. All these cluster machines build upon the same knowledge about cluster software management, scheduling, middleware libraries and mathematical libraries. In this study, we have integrated COTS processing resources and cluster nodes into a very high performance processing platform suitable for streaming data applications, in particular to implement a correlator. The required processing power for the correlator in modern radio telescopes is in the range of the larger supercomputers, which motivates the usage of supercomputer technology. Raw processing power is provided by graphical processors and is combined with an Infiniband host bus adapter with integrated data stream handling logic. With this processing platform a scalable correlator can be built with continuously growing processing power at consumer market prices.

  15. Platform development supportedby gaming

    DEFF Research Database (Denmark)

    Mikkola, Juliana Hsuan; Hansen, Poul H. Kyvsgård

    2007-01-01

    The challenge of implementing industrial platforms in practice can be described as a configuration problem caused by high number of variables, which often have contradictory influences on the total performance of the firm. Consequently, the specific platform decisions become extremely complex......, possibly increasing the strategic risks for the firm. This paper reports preliminary findings on platform management process at LEGO, a Danish toy company.  Specifically, we report the process of applying games combined with simulations and workshops in the platform development. We also propose a framework......, based on the portfolio management thinking, to measure the degree of modularity embedded in a given platform and to what extent it is aligned with other platforms....

  16. A Novel Microfluidic Cell Co-culture Platform for the Study of the Molecular Mechanisms of Parkinson's Disease and Other Synucleinopathies

    Science.gov (United States)

    Fernandes, João T. S.; Chutna, Oldriska; Chu, Virginia; Conde, João P.; Outeiro, Tiago F.

    2016-01-01

    Although, the precise molecular mechanisms underlying Parkinson's disease (PD) are still elusive, it is now known that spreading of alpha-synuclein (aSyn) pathology and neuroinflammation are important players in disease progression. Here, we developed a novel microfluidic cell-culture platform for studying the communication between two different cell populations, a process of critical importance not only in PD but also in many biological processes. The integration of micro-valves in the device enabled us to control fluid routing, cellular microenvironments, and to simulate paracrine signaling. As proof of concept, two sets of experiments were designed to show how this platform can be used to investigate specific molecular mechanisms associated with PD. In one experiment, naïve H4 neuroglioma cells were co-cultured with cells expressing aSyn tagged with GFP (aSyn-GFP), to study the release and spreading of the protein. In our experimental set up, we induced the release of the contents of aSyn-GFP producing cells to the medium and monitored the protein's diffusion. In another experiment, H4 cells were co-cultured with N9 microglial cells to assess the interplay between two cell lines in response to environmental stimuli. Here, we observed an increase in the levels of reactive oxygen species in H4 cells cultured in the presence of activated N9 cells, confirming the cross talk between different cell populations. In summary, the platform developed in this study affords novel opportunities for the study of the molecular mechanisms involved in PD and other neurodegenerative diseases. PMID:27895548

  17. DFH-3 Satellite Platform

    Institute of Scientific and Technical Information of China (English)

    RenShufang

    2005-01-01

    The DFH-3 satellite platform is designed and developed by China Academy of Space Technology (CAST). It is a medium capability communications satellite platform. The platform adopts threeaxis attitude stabilization control system, having solar array output power of 1.7kW by the end of its design lifetime of 8 years. Its mass is 2100kg with payload capacity of 220kg.

  18. Product Platform Replacements

    DEFF Research Database (Denmark)

    Sköld, Martin; Karlsson, Christer

    2012-01-01

    Purpose – It is argued in this article that too little is known about product platforms and how to deal with them from a manager's point of view. Specifically, little information exists regarding when old established platforms are replaced by new generations in R&D and production environments...... originality and value is achieved by focusing on product platform replacements believed to represent a growing management challenge....

  19. Cloud Computing as Evolution of Distributed Computing – A Case Study for SlapOS Distributed Cloud Computing Platform

    Directory of Open Access Journals (Sweden)

    George SUCIU

    2013-01-01

    Full Text Available The cloud computing paradigm has been defined from several points of view, the main two directions being either as an evolution of the grid and distributed computing paradigm, or, on the contrary, as a disruptive revolution in the classical paradigms of operating systems, network layers and web applications. This paper presents a distributed cloud computing platform called SlapOS, which unifies technologies and communication protocols into a new technology model for offering any application as a service. Both cloud and distributed computing can be efficient methods for optimizing resources that are aggregated from a grid of standard PCs hosted in homes, offices and small data centers. The paper fills a gap in the existing distributed computing literature by providing a distributed cloud computing model which can be applied for deploying various applications.

  20. A Class of Generalized Gough-Stewart Platforms Used for Effectively Obtaining Dynamic Isotropy – An Analytical Study

    Directory of Open Access Journals (Sweden)

    Afzali-Far Behrouz

    2015-01-01

    Full Text Available In this paper, we propose a class of Generalized Gough-Stewart Platforms (GGSPs used, as a novel approach, to eliminate the classical isotropic constraint of GSPs (hexapods. GGSPs are based on the standard GSP architecture with additional rotations of the three strut-pairs. Despite the architectural generalization introduced in GGSPs, they do not require much more effort in order to be fabricated. This is due to the fact that all the struts (actuators can be chosen identical, similar to standard GSPs. We analytically show how effectively the classical isotropic constraint is removed and that still sufficient simplicity is retained. Furthermore, this paper gives an intuitive understanding of dynamic isotropy in GGSPs as well as GSPs.

  1. A study of rotor and platform design trade-offs for large-scale floating vertical axis wind turbines

    Science.gov (United States)

    Griffith, D. Todd; Paquette, Joshua; Barone, Matthew; Goupee, Andrew J.; Fowler, Matthew J.; Bull, Diana; Owens, Brian

    2016-09-01

    Vertical axis wind turbines are receiving significant attention for offshore siting. In general, offshore wind offers proximity to large populations centers, a vast & more consistent wind resource, and a scale-up opportunity, to name a few beneficial characteristics. On the other hand, offshore wind suffers from high levelized cost of energy (LCOE) and in particular high balance of system (BoS) costs owing to accessibility challenges and limited project experience. To address these challenges associated with offshore wind, Sandia National Laboratories is researching large-scale (MW class) offshore floating vertical axis wind turbines (VAWTs). The motivation for this work is that floating VAWTs are a potential transformative technology solution to reduce offshore wind LCOE in deep-water locations. This paper explores performance and cost trade-offs within the design space for floating VAWTs between the configurations for the rotor and platform.

  2. A Unique Approach for Studying Venus’s Atmosphere: Technology Development for the Venus Atmospheric Maneuverable Platform (VAMP)

    Science.gov (United States)

    Samuele, Rocco; Lee, Greg; Sokol, Daniel; Polidan, Ron; Griffin, Kristen; Bolisay, Linden; Michi, Yuki; Barnes, Nathan

    2014-11-01

    We are investigating a novel, reduced-risk approach to long-duration upper atmosphere exploration of Venus. The Venus Atmospheric Maneuverable Platform (VAMP) concept is a semi-buoyant plane with a science payload that can perform in situ measurements of Venus’s atmosphere. VAMP is also capable of revisiting scientifically interesting locations. Designed with a low ballistic coefficient, VAMP deploys in space and enters Venus’s atmosphere without an aeroshell. Once in the atmosphere, it can engage in a variety of science campaigns while varying its altitude between 50 and 68 km as it circumnavigates Venus. During daytime, VAMP will be able to make continuous science measurements at a range of latitudes, longitudes, and altitudes, while at night the vehicle will descend to a fully-buoyant, lower-power state, capable of performing modest science measurements at the float altitude. Near the end of VAMP’s mission life, the vehicle may attempt an end-of-life trajectory into higher latitudes or descend to lower altitudes. This presentation focuses on the technology roadmap that will allow the vehicle to accomplish these science measurements. The roadmap is driven by high priority science measurements and the technology needed to implement VAMP’s main mission phases: deployment, entry into Venus’s atmosphere, and the transition to flight and science flight performance. The roadmap includes materials tests, planform aerodynamic characterization, various subscale and full-scale packaging and deployment tests, and a full-scale suborbital flight and is being produced with extensive science community interaction to define the science measurements that would be uniquely possible with this new science platform.

  3. Orbital transfer vehicle concept definition and system analysis study. Volume 2: OTV concept definition and evaluation. Book 3: Subsystem trade studies

    Science.gov (United States)

    Dickman, Glen J.

    1987-01-01

    The technical trade studies and analyses reported in this book represent the accumulated work of the technical staff for the contract period. The general disciplines covered are as follows: (1) Guidance, Navigation, and Control; (2) Avionics Hardware; (3) Aeroassist Technology; (4) Propulsion; (5) Structure and Materials; and (6) Thermal Control Technology. The objectives in each of these areas were to develop the latest data, information, and analyses in support of the vehicle design effort.

  4. The Creative Platform

    DEFF Research Database (Denmark)

    Byrge, Christian; Hansen, Søren

    This book is about introducing more creativity into general educational courses and cross-disciplinary activities. It is directed toward teachers at all levels in the educational system, but the Creative Platform is a general model, and thus the creative process will fundamentally be the same...... whether you consider thirdgrade teaching, human-resource development, or radical new thinking in product development in a company. The Creative Platform was developed at Aalborg University through a series of research-and-development activities in collaboration with educational institutions and private...... you can use in your work with the Creative Platform. This book is intended as an introduction on how to use the Creative Platform....

  5. Omnidirectional holonomic platforms

    Energy Technology Data Exchange (ETDEWEB)

    Pin, F.G.; Killough, S.M.

    1994-06-01

    This paper presents the concepts for a new family of wheeled platforms which feature full omnidirectionality with simultaneous and independently controlled rotational and translational motion capabilities. The authors first present the orthogonal-wheels concept and the two major wheel assemblies on which these platforms are based. They then describe how a combination of these assemblies with appropriate control can be used to generate an omnidirectional capability for mobile robot platforms. The design and control of two prototype platforms are then presented and their respective characteristics with respect to rotational and translational motion control are discussed.

  6. PROBLEM OF THE DEFINITION THE «RELIABILITY» TERM. METHODOLOGY OF CONSTRUCTION AND STUDY THE RELIABILITY OF FREIGHT CARS

    Directory of Open Access Journals (Sweden)

    S. V. Myamlin

    2015-09-01

    Full Text Available Purpose. Scientific paper is aimed at disclosing the existing problem of the «reliability» definition and provides a reasoned definition of the term. The study assumes the development of a complex that includes the methodology and appropriate terminology that will be true. Methodology. Currently there is reliability theory in the special case of the probabilistic and statistical theory, which is used to determine or predict the occurrence of object failures. Within the existing theories the term «reliability» is formulated, the parameters related to it are described. Findings. On the basis of the conducted analysis of the research within the existing theory of reliability and personal considerations of the authors, they formulated a definition of the term «reliability». The methodology and study of the object reliability on the example of a freight car was proposed. Originality. The authors proposed a new definition of the «reliability» term. Namely: reliability is an assessment of the ability of an object to maintain the original property within the established limits and temporary space, in the conditions of storage and transportation, as well as to perform the required functions in predetermined modes of operation with maintenance and repair facility. The reliability parameters include: reliability, durability, maintainability and safety that characterize the object. Also a methodology for developing and study the reliability of a freight car was developed, which comprises: 1 design, technological and operational reliability; 2 scientific experiment, including the modeling of the freight car in different conditions and operating modes; 3 the reliability theory is presented as combined or modified, covering the mathematical and physical foundations; 4 Bayesian statistics that describe the different states of a freight car with a breakdown of its basic components and with the appropriate probability for each component to describe the

  7. Study of high-definition and stereoscopic head-aimed vision for improved teleoperation of an unmanned ground vehicle

    Science.gov (United States)

    Tyczka, Dale R.; Wright, Robert; Janiszewski, Brian; Chatten, Martha Jane; Bowen, Thomas A.; Skibba, Brian

    2012-06-01

    Nearly all explosive ordnance disposal robots in use today employ monoscopic standard-definition video cameras to relay live imagery from the robot to the operator. With this approach, operators must rely on shadows and other monoscopic depth cues in order to judge distances and object depths. Alternatively, they can contact an object with the robot's manipulator to determine its position, but that approach carries with it the risk of detonation from unintentionally disturbing the target or nearby objects. We recently completed a study in which high-definition (HD) and stereoscopic video cameras were used in addition to conventional standard-definition (SD) cameras in order to determine if higher resolutions and/or stereoscopic depth cues improve operators' overall performance of various unmanned ground vehicle (UGV) tasks. We also studied the effect that the different vision modes had on operator comfort. A total of six different head-aimed vision modes were used including normal-separation HD stereo, SD stereo, "micro" (reduced separation) SD stereo, HD mono, and SD mono (two types). In general, the study results support the expectation that higher resolution and stereoscopic vision aid UGV teleoperation, but the degree of improvement was found to depend on the specific task being performed; certain tasks derived notably more benefit from improved depth perception than others. This effort was sponsored by the Joint Ground Robotics Enterprise under Robotics Technology Consortium Agreement #69-200902 T01. Technical management was provided by the U.S. Air Force Research Laboratory's Robotics Research and Development Group at Tyndall AFB, Florida.

  8. Digital platforms as enablers for digital transformation

    DEFF Research Database (Denmark)

    Hossain, Mokter; Lassen, Astrid Heidemann

    2017-01-01

    Digital platforms offer new ways for organizations to collaborate with the external environment for ideas, technologies, and knowledge. They provide new possibilities and competence but they also bring new challenges for organizations. Understanding the role of these platforms in digital...... transformation is crucial. This study aims at exploring how organizations are driven towards transformation in various ways to embrace digital platforms for ideas, technologies, and knowledge. It shows the opportunities and challenges digital platforms bring in organizations. It also highlights underlying...... mechanisms and potential outcomes of various digital platforms. The contribution of the submission is valuable for scholars to understand and further explore this area. It provides insight for practitioners to capture value through digital platforms and accelerate the pace of organizations’ digital...

  9. Neuroretinitis -- definition

    Science.gov (United States)

    ... page: //medlineplus.gov/ency/article/007624.htm Neuroretinitis - definition To use the sharing features on this page, ... this important distinction for online health information and services. Learn more about A.D.A.M.'s editorial ...

  10. Definition of curriculum and approach: study of a training course for teachers of non-formal education in NGOs

    OpenAIRE

    Deivis Perez

    2014-01-01

    This article presents a research aimed to analyze the approach and the definition of guiding curriculum of teacher training for work in the non-formal education in non-governmental organizations (NGOs). We opted for a qualitative approach and case study of Te- acher Training Course for NGOs, developed by Ong São Paulo-SP. The research instruments were: analysis of documents of the cou- rse, interviews with trainers and coordinator and literature review. In this course, curriculum is defined a...

  11. Market Definition

    OpenAIRE

    Kaplow, Louis

    2014-01-01

    Market definition has long held a central place in competition law. This entry surveys recent analytical work that has called the market definition paradigm into question on a number of fronts: whether the process is feasible, whether market share threshold tests are coherent, whether the hypothetical monopolist test in merger guidelines is counterproductive, and whether and when the frequent focus on cross-elasticities is useful.

  12. Knowledge platform for calculating climate impact from construction and building materials. Literature study; Kunnskapsplattform for beregning av klimabelastning fra bygg og byggematerialer. Litteraturstudie

    Energy Technology Data Exchange (ETDEWEB)

    Roenning, Anne; Lyng, Kari-Anne; Vold, Mie

    2011-07-01

    Greenhouse gas emissions from building linked today to a large extent to the energy consumption during the operating period. Through increasingly stringent energy requirements and other changes, the energy consumption for the operation could go down over time. This means in this case that the energy required to produce, transport and set up the building, to a greater extent can be relatively more important in a life-cycle analysis. KRD in that regard ha given Oestfoldforskning the commission to conduct a literature study that will provide an overview and assessment of the literature / research papers describing various building materials climate impact and how this translates into a lifetime (LCA - Life Cycle Assessment), and thus describe the knowledge platform these analyzes are based in. It also means a description of the factors that affect the climate and the environment, including the stages of life that are important. Literature study is conducted by searching scientific databases (Springer Link, Science Direct, Google Scholar, Norwegian EPD database of declarations). The literature search is limited to studies that are based on LCA as a methodology for calculating the climate impacts associated with the construction and building materials. Based on the review of literature is also undertaken an analysis focusing on explaining the methodological platform between the studies are based on, in order to explain why the results differ and / or may not be comparable.(eb)

  13. A study of characteristics of intercity transportation systems. Phase 1: Definition of transportation comparison methodology

    Science.gov (United States)

    English, J. M.; Smith, J. L.; Lifson, M. W.

    1978-01-01

    Decision making in early transportation planning must be responsive to complex value systems representing various policies and objectives. The assessment of alternative transportation concepts during the early initial phases of the system life cycle, when supportive research and technology development activities are defined, requires estimates of transportation, environmental, and socio-economic impacts throughout the system life cycle, which is a period of some 40 or 50 years. A unified methodological framework for comparing intercity passenger and freight transportation systems is described and is extended to include the comparison of long term transportation trends arising from implementation of the various R & D programs. The attributes of existing and future transportation systems are reviewed in order to establish measures for comparison, define value functions, and attribute weightings needed for comparing alternative policy actions for furthering transportation goals. Comparison criteria definitions and an illustrative example are included.

  14. Robust Design Rule with Definite Purpose Character Based on Fuzzy Probability and Study of its Characteristics

    Institute of Scientific and Technical Information of China (English)

    ZHANG Long-ting; HE Zhe-ming; GUO Hui-xin

    2003-01-01

    The design target with definite purpose character of product quality was described in a real fuzzy number ( named fury target for short in this paper), and its membership functions in common use were given. According to the fury probability theory and the robust design principle, the robust design rule based on fuzzy probability (named fuzzy robust design rule for short) was put forward and its validity and practicability were analyzed and tested with a design example. The theoretical analysis and the design examples make clear that, while the fuzzy robust design rule was used, the fine design effect can be obtained and the fury robust design rule can be very suitable for the choice of the membership function of the fuzzy target; so it has a particular advantage.

  15. Moodle vs. Social Media Platforms

    DEFF Research Database (Denmark)

    Gulieva, Valeria

    Given the competition coming from various social media platforms, it is explored in this paper how students could be encouraged to use Moodle more proactively during their studies. Moodle is a course management system for online learning. It is designed to be a flexible template-based system, which......, known and widely used social platforms. It might be also due to the fact that students do not see the benefits in investing time and efforts in learning the new system. Another reason might be the mandatory nature of Moodle, i.e., it is imposed on students, rather than a free choice – and this might...

  16. An Investigation of Digital Payment Platform Designs

    DEFF Research Database (Denmark)

    Kazan, Erol; Damsgaard, Jan

    2014-01-01

    platforms that combines platform, technology and business design aspects. The framework is applied to conduct a comparative case study of digital payment platforms. Four types of market actors are considered: banks, mobile network operators, merchants, and startups, which are incumbents and disrupters....... By hosting third-party services, payment instruments are evolving from single-purpose to multi-functional ones. Our research extends existing payment literature from the MSP perspective to emphasize certain digital payment platform components, which impact strategies and complementary products....

  17. The Innovative Capabilities Of Digital Payment Platforms

    DEFF Research Database (Denmark)

    Kazan, Erol

    2015-01-01

    the support for open innovation. The proposed model has been employed in a comparative case study between two digital payment platforms: Apple Pay and Google Wallet. The findings suggest that digital payment platforms make use of boundary resources to be highly integrative or integratable, which supports...... the intended conjoint commercialization efforts. Furthermore, the architectural design of digital platforms impacts the access to commercialization, resulting to an exclusion or inclusion strategy in accessing value opportunities. Our findings contribute to the open innovation and digital platform literature...

  18. Advanced offshore oil platforms

    Energy Technology Data Exchange (ETDEWEB)

    Ellers, F.S.

    1982-04-01

    Four innovative offshore platforms that are designed to withstand 100-foot waves in waters 600-feet deep are described. These platforms are: (1) Stratfjord B Concrete Gravity-Base Platform; (2) Magnus Steel-Template-Jacket Platform; (3) Hutton Tension-Leg Platform; and (4) Block 280 Guyed Tower. The Statfjord B platform, designed in Norway, rests on four massive concrete columns with storage tanks at the base. It depends solely on its own mass for stability. The Magnus platform, designed by the British, is the heaviest offshore platform yet fabricated, weighing 41,000 tons. Two of the platform's four legs will incorporate flotation chambers so that the structure can be floated to its site in the North Sea. The Hutton structure, also designed in England, will consist of a buoyant hull tethered to the sea floor by slender steel tubes at its four corners. The first platform of its type, the Hutton structure is also destined for the North Sea. The US designed Block 280 guyed tower is designed for service in the Gulf of Mexico in water 1000 feet deep. It will be pinned to the sea floor by a spokelike array of 20 steel cables, each one more than 3000 feet long. The tower and its guys will weigh 43,000 tons, slightly more than the Magnus steel-template jacket and more than four time as much as the Eiffel Tower. At a cost of approximately $2.6 billion, the Magnus is the most expensive offshore platform to date. The Statfjord B was put into production in 1982. The Magnus is scheduled for oil production in 1983. The Hutton and the Block 280 will both be producing in 1984. (JMT)

  19. Proposed diagnostic criteria for the case definition of amniotic fluid embolism in research studies.

    Science.gov (United States)

    Clark, Steven L; Romero, Roberto; Dildy, Gary A; Callaghan, William M; Smiley, Richard M; Bracey, Arthur W; Hankins, Gary D; D'Alton, Mary E; Foley, Mike; Pacheco, Luis D; Vadhera, Rakesh B; Herlihy, J Patrick; Berkowitz, Richard L; Belfort, Michael A

    2016-10-01

    Amniotic fluid embolism is a leading cause of maternal mortality in developed countries. Our understanding of risk factors, diagnosis, treatment, and prognosis is hampered by a lack of uniform clinical case definition; neither histologic nor laboratory findings have been identified unique to this condition. Amniotic fluid embolism is often overdiagnosed in critically ill peripartum women, particularly when an element of coagulopathy is involved. Previously proposed case definitions for amniotic fluid embolism are nonspecific, and when viewed through the eyes of individuals with experience in critical care obstetrics, would include women with a number of medical conditions much more common than amniotic fluid embolism. We convened a working group under the auspices of a committee of the Society for Maternal-Fetal Medicine and the Amniotic Fluid Embolism Foundation whose task was to develop uniform diagnostic criteria for the research reporting of amniotic fluid embolism. These criteria rely on the presence of the classic triad of hemodynamic and respiratory compromise accompanied by strictly defined disseminated intravascular coagulopathy. It is anticipated that limiting research reports involving amniotic fluid embolism to women who meet these criteria will enhance the validity of published data and assist in the identification of risk factors, effective treatments, and possibly useful biomarkers for this condition. A registry has been established in conjunction with the Perinatal Research Branch of the Eunice Kennedy Shriver National Institute of Child Health and Human Development to collect both clinical information and laboratory specimens of women with suspected amniotic fluid embolism in the hopes of identifying unique biomarkers of this condition.

  20. Scientific Foundation of the Engineering Platform

    DEFF Research Database (Denmark)

    Falster, Peter; Franksen, Ole Immanuel

    1996-01-01

    The primary aim of the definition sequence is to establish the mathematical platform for software development in particular with a view towards array-based logic. The secondary aim is to establish an approach for teaching array theory. The definition sequence has been developed in the spirit...... of array theory developed by dr. Trenchard More. In order to check the definition sequence we made a comparison to APL2, Iverson's J language, functional programming languages and Backus' FP. The establishment of the set of primitives is considered as an engineering design project. The result...... of this is that from eight primitives which can be related to the axioms of Zermelo-Fraenkel's set theory we can build all the functions of the pure array theory....

  1. [New definition of ventilator associated pneumonia might not necessarily have been a step in the right direction. Key takeaways from published studies after two years in clinical use].

    Science.gov (United States)

    Zamaro-Michalska, Aleksandra; Adamczyk, Agata; Mikaszewska-Sokolewicz, Małgorzata; Siewiera, Jacek; Łazowski, Tomasz

    2015-12-01

    Ventilator-associated pneumonia (VAP) is one of the most common hospital-acquired infections. VAP is associated with prolonged hospitalization and visibly increased mortality, which in the group of patients with VAP ranges from 25% to 47%. In January 2013 Centers of Disease Control and Prevention introduced a new definition for VAP. Subjective criteria in the previous VAP definition were the reason for difficulties in VAP surveillance and assessment of efficacy of ventilator bundles and other quality improvement initiatives. The purpose of this article is to summarise the new definition of VAP and the first researches after two years of use of the new definition. The new definition of ventilator-associated events (VAE) identifies a broader group of patients than the previous VAP definition. Surveillance of all complications of mechanical ventilation aimed to create more efficient prophylaxis bundles and to decrease the mortality in critically ill patients. The latest published studies suggest that most of the complications defined as VAE are patient-related, not modifiable risk factors and these patients had no evidence of hospital-acquired complications. The new definition failed to detect many patients with VAP and it has not resolved the ambiguities related to the diagnosis of this complication. It seems that the new surveillance program will not lead to introducing new prevention strategies that could decrease the mortality in intensive care unit patients.

  2. Toward a definition of intolerance of uncertainty: a review of factor analytical studies of the Intolerance of Uncertainty Scale.

    Science.gov (United States)

    Birrell, Jane; Meares, Kevin; Wilkinson, Andrew; Freeston, Mark

    2011-11-01

    Since its emergence in the early 1990s, a narrow but concentrated body of research has developed examining the role of intolerance of uncertainty (IU) in worry, and yet we still know little about its phenomenology. In an attempt to clarify our understanding of this construct, this paper traces the way in which our understanding and definition of IU have evolved throughout the literature. This paper also aims to further our understanding of IU by exploring the latent variables measures by the Intolerance of Uncertainty Scale (IUS; Freeston, Rheaume, Letarte, Dugas & Ladouceur, 1994). A review of the literature surrounding IU confirmed that the current definitions are categorical and lack specificity. A critical review of existing factor analytic studies was carried out in order to determine the underlying factors measured by the IUS. Systematic searches yielded 9 papers for review. Two factors with 12 consistent items emerged throughout the exploratory studies, and the stability of models containing these two factors was demonstrated in subsequent confirmatory studies. It is proposed that these factors represent (i) desire for predictability and an active engagement in seeking certainty, and (ii) paralysis of cognition and action in the face of uncertainty. It is suggested that these factors may represent approach and avoidance responses to uncertainty. Further research is required to confirm the construct validity of these factors and to determine the stability of this structure within clinical samples.

  3. Towards a Market Entry Framework for Digital Payment Platforms

    DEFF Research Database (Denmark)

    Kazan, Erol; Damsgaard, Jan

    2016-01-01

    This study presents a framework to understand and explain the design and configuration of digital payment platforms and how these platforms create conditions for market entries. By embracing the theoretical lens of platform envelopment, we employed a multiple and comparative-case study...... in a European setting by using our framework as an analytical lens to assess market-entry conditions. We found that digital payment platforms have acquired market entry capabilities, which is achieved through strategic platform design (i.e., platform development and service distribution) and technology design...... (i.e., issuing evolutionary and revolutionary payment instruments). The studied cases reveal that digital platforms leverage payment services as a mean to bridge and converge core and adjacent platform markets. In so doing, platform envelopment strengthens firms’ market position in their respective...

  4. Towards a Market Entry Framework for Digital Payment Platforms

    DEFF Research Database (Denmark)

    Kazan, Erol; Damsgaard, Jan

    2016-01-01

    (i.e., issuing evolutionary and revolutionary payment instruments). The studied cases reveal that digital platforms leverage payment services as a mean to bridge and converge core and adjacent platform markets. In so doing, platform envelopment strengthens firms’ market position in their respective......This study presents a framework to understand and explain the design and configuration of digital payment platforms and how these platforms create conditions for market entries. By embracing the theoretical lens of platform envelopment, we employed a multiple and comparative-case study...... in a European setting by using our framework as an analytical lens to assess market-entry conditions. We found that digital payment platforms have acquired market entry capabilities, which is achieved through strategic platform design (i.e., platform development and service distribution) and technology design...

  5. EURESCOM Services Platform

    NARCIS (Netherlands)

    Nieuwenhuis, Lambertus Johannes Maria; van Halteren, Aart

    1999-01-01

    This paper presents the results of the EURESCOM Project 715. In February 1999, a large team of researchers from six European public network operators completed a two year period of cooperative experiments on a TINA-based environment, called the EURESCOM Services Platform (ESP). This platform

  6. 基于云计算技术的图书馆服务平台实证研究--以“陶风采”图书馆服务平台为例%Empirical Study of Cloud Computing Technology-based Library Services Platform:A Case Study of“Taofengcai”Library Services Platform

    Institute of Scientific and Technical Information of China (English)

    徐路

    2016-01-01

    This paper discusses the conceptual definition,architecture,business process,innovation points and disadvantages of the “Taofengcai”about library service platform based on the cloud computing technique,and further research direction is also provided. This paper mainly analyzes IaaS、PaaS、SaaS and client server. Meanwhile,and also give some suggestion on improving the level of security,enhancing borrowing and purchasing rules,planning the con-struction structure of library collections reasonably,improving the quality of business and increasing the number of co-operative enterprises,and issuing the platform specification.%文章以云计算为着眼点,介绍了“陶风采”图书馆服务平台的内涵、架构、业务流程、创新点、存在的问题及其解决建议。重点分析了基础设施即服务(IaaS)、平台即服务(PaaS)、软件即服务(SaaS)、客户服务端四大功能模块,提出提高安全保障水平、完善借购控制规则、优化馆藏布局结构、加强业务素养教育、扩大合作单位范围、制定平台标准规范等措施。

  7. Beyond xMOOCs in healthcare education: study of the feasibility in integrating virtual patient systems and MOOC platforms

    Directory of Open Access Journals (Sweden)

    Natalia Stathakarou

    2014-11-01

    Full Text Available Background. Massive Open Online Courses (MOOCs are an emerging trend in online learning. However, their technology is not yet completely adjusted to the needs of healthcare education. Integration of Virtual Patients within MOOCs to increase interactivity and foster clinical reasoning skills training, has been discussed in the past, but not verified by a practical implementation.Objective. To investigate the technical feasibility of integrating MOOCs with Virtual Patients for the purpose of enabling further research into the potential pedagogical benefits of this approach.Methods. We selected OpenEdx and Open Labyrinth as representative constituents of a MOOC platform and Virtual Patient system integration. Based upon our prior experience we selected the most fundamental technical requirement to address. Grounded in the available literature we identified an e-learning standard to guide the integration. We attempted to demonstrate the feasibility of the integration by designing a “proof-of-concept” prototype. The resulting pilot implementation was subject of verification by two test cases.Results. A Single Sign-On mechanism connecting Open Labyrinth with OpenEdx and based on the IMS LTI standard was successfully implemented and verified.Conclusion. We investigated the technical perspective of integrating Virtual Patients with MOOCs. By addressing this crucial technical requirement we set a base for future research on the educational benefits of using virtual patients in MOOCs. This provides new opportunities for integrating specialized software in healthcare education at massive scale.

  8. Beyond xMOOCs in healthcare education: study of the feasibility in integrating virtual patient systems and MOOC platforms.

    Science.gov (United States)

    Stathakarou, Natalia; Zary, Nabil; Kononowicz, Andrzej A

    2014-01-01

    Background. Massive Open Online Courses (MOOCs) are an emerging trend in online learning. However, their technology is not yet completely adjusted to the needs of healthcare education. Integration of Virtual Patients within MOOCs to increase interactivity and foster clinical reasoning skills training, has been discussed in the past, but not verified by a practical implementation. Objective. To investigate the technical feasibility of integrating MOOCs with Virtual Patients for the purpose of enabling further research into the potential pedagogical benefits of this approach. Methods. We selected OpenEdx and Open Labyrinth as representative constituents of a MOOC platform and Virtual Patient system integration. Based upon our prior experience we selected the most fundamental technical requirement to address. Grounded in the available literature we identified an e-learning standard to guide the integration. We attempted to demonstrate the feasibility of the integration by designing a "proof-of-concept" prototype. The resulting pilot implementation was subject of verification by two test cases. Results. A Single Sign-On mechanism connecting Open Labyrinth with OpenEdx and based on the IMS LTI standard was successfully implemented and verified. Conclusion. We investigated the technical perspective of integrating Virtual Patients with MOOCs. By addressing this crucial technical requirement we set a base for future research on the educational benefits of using virtual patients in MOOCs. This provides new opportunities for integrating specialized software in healthcare education at massive scale.

  9. Laboratory Information Management Platform Study%实验室开放信息化管理平台研究

    Institute of Scientific and Technical Information of China (English)

    田明江; 高国元

    2012-01-01

    With the development of experimental teaching,more and more obvious,seriously hindered the development of the student's imagination and thinking skills,closely follow the trend of the times,follow the development to explore new teaching mode potential in the pipeline. To take full advantage of existing laboratory resources,saving students' time,reduce the intensity of the work of teachers,especially the Laboratory information management platform.%随着时代的发展,传统的实验教学存在的问题,越来越明显,严重束缚了学生的想象力和思维能力的开发,紧跟时代潮流,顺应时代发展,探讨新的实验教学模式势在必行。为了充分利用现有的实验室资源,节约学生的学习时间,降低教师的工作强度,特进行了实验室开放信息化管理平台研究。

  10. An Exploratory Study of the Cultural Habits Change Process Triggered by the Use of IT: A Faculty Student Knowledge-Sharing Platform Case Study

    Science.gov (United States)

    Young, Mei-Lien

    2012-01-01

    In this research, we explore the impact on teachers of implementation of the Faculty Student Knowledge-Sharing Platform (FSKSP) in their college. Specifically, we focus on the effect on those teachers of the need to share publicly their knowledge and teaching material as the result of FSKSP implementation. In addition, we report the experience and…

  11. The Need for a Definition of Big Data for Nursing Science: A Case Study of Disaster Preparedness

    Directory of Open Access Journals (Sweden)

    Ho Ting Wong

    2016-10-01

    Full Text Available The rapid development of technology has made enormous volumes of data available and achievable anytime and anywhere around the world. Data scientists call this change a data era and have introduced the term “Big Data”, which has drawn the attention of nursing scholars. Nevertheless, the concept of Big Data is quite fuzzy and there is no agreement on its definition among researchers of different disciplines. Without a clear consensus on this issue, nursing scholars who are relatively new to the concept may consider Big Data to be merely a dataset of a bigger size. Having a suitable definition for nurse researchers in their context of research and practice is essential for the advancement of nursing research. In view of the need for a better understanding on what Big Data is, the aim in this paper is to explore and discuss the concept. Furthermore, an example of a Big Data research study on disaster nursing preparedness involving six million patient records is used for discussion. The example demonstrates that a Big Data analysis can be conducted from many more perspectives than would be possible in traditional sampling, and is superior to traditional sampling. Experience gained from the process of using Big Data in this study will shed light on future opportunities for conducting evidence-based nursing research to achieve competence in disaster nursing.

  12. The Need for a Definition of Big Data for Nursing Science: A Case Study of Disaster Preparedness

    Science.gov (United States)

    Wong, Ho Ting; Chiang, Vico Chung Lim; Choi, Kup Sze; Loke, Alice Yuen

    2016-01-01

    The rapid development of technology has made enormous volumes of data available and achievable anytime and anywhere around the world. Data scientists call this change a data era and have introduced the term “Big Data”, which has drawn the attention of nursing scholars. Nevertheless, the concept of Big Data is quite fuzzy and there is no agreement on its definition among researchers of different disciplines. Without a clear consensus on this issue, nursing scholars who are relatively new to the concept may consider Big Data to be merely a dataset of a bigger size. Having a suitable definition for nurse researchers in their context of research and practice is essential for the advancement of nursing research. In view of the need for a better understanding on what Big Data is, the aim in this paper is to explore and discuss the concept. Furthermore, an example of a Big Data research study on disaster nursing preparedness involving six million patient records is used for discussion. The example demonstrates that a Big Data analysis can be conducted from many more perspectives than would be possible in traditional sampling, and is superior to traditional sampling. Experience gained from the process of using Big Data in this study will shed light on future opportunities for conducting evidence-based nursing research to achieve competence in disaster nursing. PMID:27763525

  13. The Need for a Definition of Big Data for Nursing Science: A Case Study of Disaster Preparedness.

    Science.gov (United States)

    Wong, Ho Ting; Chiang, Vico Chung Lim; Choi, Kup Sze; Loke, Alice Yuen

    2016-10-17

    The rapid development of technology has made enormous volumes of data available and achievable anytime and anywhere around the world. Data scientists call this change a data era and have introduced the term "Big Data", which has drawn the attention of nursing scholars. Nevertheless, the concept of Big Data is quite fuzzy and there is no agreement on its definition among researchers of different disciplines. Without a clear consensus on this issue, nursing scholars who are relatively new to the concept may consider Big Data to be merely a dataset of a bigger size. Having a suitable definition for nurse researchers in their context of research and practice is essential for the advancement of nursing research. In view of the need for a better understanding on what Big Data is, the aim in this paper is to explore and discuss the concept. Furthermore, an example of a Big Data research study on disaster nursing preparedness involving six million patient records is used for discussion. The example demonstrates that a Big Data analysis can be conducted from many more perspectives than would be possible in traditional sampling, and is superior to traditional sampling. Experience gained from the process of using Big Data in this study will shed light on future opportunities for conducting evidence-based nursing research to achieve competence in disaster nursing.

  14. Three-dimensional finite element analysis of platform switched implant

    Science.gov (United States)

    2017-01-01

    PURPOSE The purpose of this study was to analyze the influence of the platform switching concept on an implant system and peri-implant bone using three-dimensional finite element analysis. MATERIALS AND METHODS Two three-dimensional finite element models for wide platform and platform switching were created. In the wide platform model, a wide platform abutment was connected to a wide platform implant. In the platform switching model, the wide platform abutment of the wide platform model was replaced by a regular platform abutment. A contact condition was set between the implant components. A vertical load of 300 N was applied to the crown. The maximum von Mises stress values and displacements of the two models were compared to analyze the biomechanical behavior of the models. RESULTS In the two models, the stress was mainly concentrated at the bottom of the abutment and the top surface of the implant in both models. However, the von Mises stress values were much higher in the platform switching model in most of the components, except for the bone. The highest von Mises values and stress distribution pattern of the bone were similar in the two models. The components of the platform switching model showed greater displacement than those of the wide platform model. CONCLUSION Due to the stress concentration generated in the implant and the prosthodontic components of the platform switched implant, the mechanical complications might occur when platform switching concept is used. PMID:28243389

  15. Methodology of an International Study of People with Multiple Sclerosis Recruited through Web 2.0 Platforms: Demographics, Lifestyle, and Disease Characteristics.

    Science.gov (United States)

    Hadgkiss, Emily J; Jelinek, George A; Weiland, Tracey J; Pereira, Naresh G; Marck, Claudia H; van der Meer, Dania M

    2013-01-01

    Background. Despite evidence of the potential importance of the role of health and lifestyle behaviours in multiple sclerosis (MS) outcomes, there has not been a significant focus on this area of research. Aim. We aimed to recruit an international sample of people with MS at baseline and over a five-year timeframe, examine their health and lifestyle behaviours, and determine the relationship of these behaviours to self-reported disability, disease activity, and quality of life. Methods. People with MS were recruited through web 2.0 platforms including interactive websites, social media, blogs, and forums and completed a comprehensive, multifaceted online questionnaire incorporating validated and researcher-derived tools. Results. 2519 participants met inclusion criteria for this study. This paper describes the study methodology in detail and provides an overview of baseline participant demographics, clinical characteristics, summary outcome variables, and health and lifestyle behaviours. The sample described is unique due to the nature of recruitment through online media and due to the engagement of the group, which appears to be well informed and proactive in lifestyle modification. Conclusion. This sample provides a sound platform to undertake novel exploratory analyses of the association between a variety of lifestyle factors and MS outcomes.

  16. Methodology of an International Study of People with Multiple Sclerosis Recruited through Web 2.0 Platforms: Demographics, Lifestyle, and Disease Characteristics

    Directory of Open Access Journals (Sweden)

    Emily J. Hadgkiss

    2013-01-01

    Full Text Available Background. Despite evidence of the potential importance of the role of health and lifestyle behaviours in multiple sclerosis (MS outcomes, there has not been a significant focus on this area of research. Aim. We aimed to recruit an international sample of people with MS at baseline and over a five-year timeframe, examine their health and lifestyle behaviours, and determine the relationship of these behaviours to self-reported disability, disease activity, and quality of life. Methods. People with MS were recruited through web 2.0 platforms including interactive websites, social media, blogs, and forums and completed a comprehensive, multifaceted online questionnaire incorporating validated and researcher-derived tools. Results. 2519 participants met inclusion criteria for this study. This paper describes the study methodology in detail and provides an overview of baseline participant demographics, clinical characteristics, summary outcome variables, and health and lifestyle behaviours. The sample described is unique due to the nature of recruitment through online media and due to the engagement of the group, which appears to be well informed and proactive in lifestyle modification. Conclusion. This sample provides a sound platform to undertake novel exploratory analyses of the association between a variety of lifestyle factors and MS outcomes.

  17. 双寡头竞争平台的商业模式选择研究%The Study of the Business Model Selection of Duopoly Competition Platform

    Institute of Scientific and Technical Information of China (English)

    郭兰平

    2015-01-01

    By setting up a model and introducing the externality of negative intra-group network and positive inter-group network into the model,this paper studies the choice of business model of duopoly competitive plat-form. The conclusions show that the two platforms will choose to be two-sided market model if there is a large e-nough gap between the positive inter-group network externality effects brought to the merchants by the consumers and the positive inter-group network externality effects brought to the consumers by the merchants. And the two platforms will choose to be the one-sided market model if the gap is small enough between them. But if the gap is in intermediate level ,the result is mainly depends on the platform products or the degree of differentiation service and the negative intensity of intra-group network externality among the merchants.%通过建立模型,并将负的组内网络外部性和正的组间网络外部性引入到模型中,研究双寡头竞争平台的商业模式选择。研究结果表明,当消费者给商家带来的正组间网络外部性效应与商家带给消费者的正组间网络外部性效应二者之间的差距足够大时,两个平台均会选择双边市场模式;而当二者之间的差距异常小时,两个平台将选择单边市场模式;但是当二者之间的差距介于中间水平时,其结果就主要取决于平台产品或服务的差异化程度以及商家之间负的组内网络外部性强度。

  18. Maximal workload capacity on moving platforms

    NARCIS (Netherlands)

    Heus, R.; Wertheim, A.H.

    1996-01-01

    Physical tasks on a moving platform required more energy than the same tasks on a non-moving platform. In this study the maximum aerobic performance (defined as V_O2max) of people working on a moving floor was established compared to the maximal aerobic performance on a non-moving floor. The main

  19. Maximal workload capacity on moving platforms

    NARCIS (Netherlands)

    Heus, R.; Wertheim, A.H.

    1996-01-01

    Physical tasks on a moving platform required more energy than the same tasks on a non-moving platform. In this study the maximum aerobic performance (defined as V_O2max) of people working on a moving floor was established compared to the maximal aerobic performance on a non-moving floor. The main qu

  20. The Innovative Capabilities Of Digital Payment Platforms

    DEFF Research Database (Denmark)

    Kazan, Erol

    2015-01-01

    the support for open innovation. The proposed model has been employed in a comparative case study between two digital payment platforms: Apple Pay and Google Wallet. The findings suggest that digital payment platforms make use of boundary resources to be highly integrative or integratable, which supports...

  1. Definition of the basic DEMO tokamak geometry based on systems code studies

    Energy Technology Data Exchange (ETDEWEB)

    Meszaros, Botond, E-mail: botond.meszaros@efda.org [EFDA Power Plant Physics and Technology, Garching (Germany); Bachmann, Christian [EFDA Power Plant Physics and Technology, Garching (Germany); Kemp, Richard [CCFE, Culham Science Centre, Abingdon, Oxfordshire OX14 3DB (United Kingdom); Federici, Gianfranco [EFDA Power Plant Physics and Technology, Garching (Germany)

    2015-10-15

    Highlights: • The definition of the DEMO 2D geometry has been introduced. • A methodology to derive the DEMO radial and vertical builds from the PROCESS systems code results has been defined. • Other 2D and 3D geometrical assumptions required to create a sensible 3D configuration model of DEMO have been defined. - Abstract: This paper describes the methodology that has been developed and applied to derive the principal geometry of the main DEMO tokamak systems, in particular the radial and vertical cross section based on the systems code output parameters, while exact parameters are described elsewhere [1]. This procedure reviews the analysis of the radial and vertical build provided by the system code to verify critical integration interfaces, e.g. missing or too large gaps and/or insufficient thickness of components, and updates these dimensions based on results of more detailed analyses (e.g. neutronics, plasma scenario modelling, etc.) that were carried out outside of the system code in the past years. As well as providing a 3D configuration model of the DEMO tokamak for integrated engineering analysis, the results can also be used to refine the systems code model. This method, subject to continuous refinement, controls the derivation of the main machine parameters and ensures their coherence vis-à-vis a number of agreed controlled physics and engineering assumptions.

  2. Definition of curriculum and approach: study of a training course for teachers of non-formal education in NGOs

    Directory of Open Access Journals (Sweden)

    Deivis Perez

    2014-06-01

    Full Text Available This article presents a research aimed to analyze the approach and the definition of guiding curriculum of teacher training for work in the non-formal education in non-governmental organizations(NGOs. We opted for a qualitative approach and case study of Teacher Training Course for NGOs, developed by Ong São Paulo-SP. The research instruments were: analysis of documents of the course, interviews with trainers and coordinator and literature review. In this course, curriculum is defined as a path to be followed by students and instructors and the coordinator of the subjects studied. We adopted the so-called Integrated Curriculum, in which teaching occurs by the study of problem situations and integrators of learning projects. At the end, we suggest improving the course and following that information, it is hoped, one will support the production of further comparative research.

  3. Media Entrepreneurship: A Consensual Definition

    DEFF Research Database (Denmark)

    Khajeheian, Datis

    2017-01-01

    Media Entrepreneurship has been an ambiguous, unclear and controversial concept and despite of growing academic efforts in the last decade, it is still a poorly defined subject. This paper is an effort to fill this gap by providing a comprehensive definition of media entrepreneurship. Firstly......, a literature review conducted and entrepreneurship, media, opportunity and innovation as building blocks of media entrepreneurship explained. Then by using of a mixed of bibliographic method and a Delphi method with multi-stage analysis process, a consensual definition of media entrepreneurship proposed....... This definition integrates some key features of the emerging media environment such as distinction of content and platform, value delivery, opportunity development, non-monetary benefit, etc. It is expected that the findings of this research clear the ground for further researches in the field of media...

  4. Adaptation of a web-based, open source electronic medical record system platform to support a large study of tuberculosis epidemiology

    Directory of Open Access Journals (Sweden)

    Fraser Hamish SF

    2012-11-01

    Full Text Available Abstract Background In 2006, we were funded by the US National Institutes of Health to implement a study of tuberculosis epidemiology in Peru. The study required a secure information system to manage data from a target goal of 16,000 subjects who needed to be followed for at least one year. With previous experience in the development and deployment of web-based medical record systems for TB treatment in Peru, we chose to use the OpenMRS open source electronic medical record system platform to develop the study information system. Supported by a core technical and management team and a large and growing worldwide community, OpenMRS is now being used in more than 40 developing countries. We adapted the OpenMRS platform to better support foreign languages. We added a new module to support double data entry, linkage to an existing laboratory information system, automatic upload of GPS data from handheld devices, and better security and auditing of data changes. We added new reports for study managers, and developed data extraction tools for research staff and statisticians. Further adaptation to handle direct entry of laboratory data occurred after the study was launched. Results Data collection in the OpenMRS system began in September 2009. By August 2011 a total of 9,256 participants had been enrolled, 102,274 forms and 13,829 laboratory results had been entered, and there were 208 users. The system is now entirely supported by the Peruvian study staff and programmers. Conclusions The information system served the study objectives well despite requiring some significant adaptations mid-stream. OpenMRS has more tools and capabilities than it did in 2008, and requires less adaptations for future projects. OpenMRS can be an effective research data system in resource poor environments, especially for organizations using or considering it for clinical care as well as research.

  5. Study on Establishing Information Platform of Zhengzhou Aviation Logistics Park%郑州航空物流园区信息平台构建研究

    Institute of Scientific and Technical Information of China (English)

    郭军峰

    2014-01-01

    In this paper, after introducing the connotation of the logistics park and its information platform as well as the interrelationship between the two, we analyzed the current status of the construction of the Zhengzhou aviation logistics park, studied the system architecture and functions of the platform and forecast the prospect of its application.%物流信息平台的建设在很大程度上决定了物流园区的运作成功与否。在阐述物流园区和信息化平台内涵及其相互关系的前提下,对郑州航空物流园区的建设现状进行分析,指出物流信息化平台建设将会成为郑州航空物流园的主要应用模式,对郑州航空物流园信息化平台的体系框架和功能进行分析,并且对系统应用前景进行展望。

  6. A platform for studying the Rayleigh-Taylor and Richtmyer-Meshkov instabilities in a planar geometry at high energy density at the National Ignition Facility

    Science.gov (United States)

    Nagel, S. R.; Raman, K. S.; Huntington, C. M.; MacLaren, S. A.; Wang, P.; Barrios, M. A.; Baumann, T.; Bender, J. D.; Benedetti, L. R.; Doane, D. M.; Felker, S.; Fitzsimmons, P.; Flippo, K. A.; Holder, J. P.; Kaczala, D. N.; Perry, T. S.; Seugling, R. M.; Savage, L.; Zhou, Y.

    2017-07-01

    A new experimental platform has been developed at the National Ignition Facility (NIF) for studying the Rayleigh-Taylor (RT) and Richtmyer-Meshkov (RM) instabilities in a planar geometry at high-energy-densities. The platform uses 60 beams of the NIF laser to drive an initially solid shock tube containing a pre-machined interface between dense and light materials. The strong shock turns the initially solid target into a plasma and the material boundary into a fluid interface with the imprinted initial condition. The interface evolves by action of the RT and RM instabilities, and the growth is imaged with backlit x-ray radiography. We present our first data involving sinusoidal interface perturbations driven from the heavy side to the light side. Late-time radiographic images show the initial conditions reaching the deeply nonlinear regime, and an evolution of fine structure consistent with a transition to turbulence. We show preliminary comparisons with post-shot numerical simulations and discuss the implications for future campaigns.

  7. Feasibility of interstitial near-infrared radiance spectroscopy platform for ex vivo canine prostate studies: optical properties extraction, hemoglobin and water concentration, and gold nanoparticles detection

    Science.gov (United States)

    Grabtchak, Serge; Montgomery, Logan G.; Whelan, William M.

    2014-05-01

    The canine prostate is a close match for the human prostate and is used in research of prostate cancers. Determining accurately optical absorption and scattering properties of the gland in a wide spectral range (preferably in a minimally invasive way), linking optical properties to concentrations of major endogenous chromophores, and detecting the presence of localized optical inhomogeneities like inclusions of gold nanoparticles for therapeutic and diagnostic purposes, are among the major challenges for researchers. The goal of the article is to demonstrate a feasibility of the multifunctional radiance spectroscopy platform in providing the required information. For ex vivo canine prostate, extraction of the effective attenuation and diffusion coefficients using relative cw radiance measurements was demonstrated in the 650- to 900-nm range. The derived absorption coefficient was decomposed to contributions from 9.0 μM HbO2, 29.6 μM Hb, and 0.47 fractional volume of H2O. Detection of a localized inclusion containing ˜1.5.1010 gold nanorods (0.8 μg Au) at 10 mm distance from the urethra was achieved with the detector in the urethra and the light source in a virtual rectum position. The platform offers the framework for a systematic study of various chromophores in the prostate that can be used as comprehensive diagnostic markers.

  8. The Common HOL Platform

    OpenAIRE

    Adams, Mark

    2015-01-01

    The Common HOL project aims to facilitate porting source code and proofs between members of the HOL family of theorem provers. At the heart of the project is the Common HOL Platform, which defines a standard HOL theory and API that aims to be compatible with all HOL systems. So far, HOL Light and hol90 have been adapted for conformance, and HOL Zero was originally developed to conform. In this paper we provide motivation for a platform, give an overview of the Common HOL Platform's theory and...

  9. Ladder attachment platform

    Science.gov (United States)

    Swygert,; Richard, W [Springfield, SC

    2012-08-28

    A ladder attachment platform is provided that includes a base for attachment to a ladder that has first and second side rails and a plurality of rungs that extend between in a lateral direction. Also included is a user platform for having a user stand thereon that is carried by the base. The user platform may be positioned with respect to the ladder so that it is not located between a first plane that extends through the first side rail and is perpendicular to the lateral direction and a second plane that extends through the second side rail and is perpendicular to the lateral direction.

  10. Indeterminacy of definitions and criteria in mental health: case study of emotional disorders.

    Science.gov (United States)

    Nikolaidis, George

    2013-06-01

    such as the ones of theorists like Solomon, Nash, Rey, Pugmire and Lyons) as well as in comprehensive theoretical schemes combining experimental data (such as the ones provided by the works of Schachter and Singer, Ekman and Friesen, Panksepp, Damasio and Griffiths), there seems to be a radical indeterminacy of conceptual content and fundamental features of emotions in general, as well as of particular emotional states. Furthermore, there is an apparent conceptual incapability to include each and every feature of emotional states within a single comprehensive definition without making reference to contingent particularities of their biological instantiation. At least in the crucial concept of emotional states, when examined carefully, it seems that (1) there are substantial barriers to the ambitious quest for a scientific grounding of taxonomies and definitions of phenomena like emotions, due to the inability to provide an independent verification of scientific propositions; (2) all major approaches in Psychology and Psychiatry seem to have serious shortcomings in defining emotions; (3) such shortcomings have to do with fundamental issues such as the nature of mental states; (4) most ordinary concepts of emotions utilized by clinicians and researchers tend to be circular and question begging when scrutinized theoretically; and (5) historically dominant beliefs, values and cultural systems tend to influence heavily both the acceptability of such representations of emotions as well as their very nature. © 2013 John Wiley & Sons Ltd.

  11. Nosocomial infections in a Dutch neonatal intensive care unit: surveillance study with definitions for infection specifically adapted for neonates.

    Science.gov (United States)

    van der Zwet, W C; Kaiser, A M; van Elburg, R M; Berkhof, J; Fetter, W P F; Parlevliet, G A; Vandenbroucke-Grauls, C M J E

    2005-12-01

    The incidence of nosocomial infection in neonatal intensive care units (NICUs) is high compared with other wards. However, no definitions for hospital-acquired infection are available for NICUs. The aim of this study was to measure the incidence of such infections and to identify risk factors in the NICU of the VU University Medical Center, which serves as a level III regional NICU. For this purpose, a prospective surveillance was performed in 1998-2000. We designed definitions by adjusting the current definitions of the Centers for Disease Control and Prevention (CDC) for children risk factors were dichotomized. Analysis of risk factors was performed by Cox regression with time-dependent variables. The relationship between the Clinical Risk Index for Babies (CRIB) and nosocomial infection was investigated. Furthermore, for a random sample of cases, we determined whether bloodstream infection and pneumonia would also have been identified with the CDC definitions. Seven hundred and forty-two neonates were included in the study. One hundred and ninety-one neonates developed 264 infections. Bloodstream infection (N=138, 14.9/1000 patient-days) and pneumonia (N=69, 7.5/1000 patient-days) were the most common infections. Of bloodstream infections, 59% were caused by coagulase-negative staphylococci; in 21% of neonates, blood cultures remained negative. In 25% of pneumonias, Enterobacteriaceae were the causative micro-organisms; 26% of cultures remained negative. Compared with the Nosocomial Infections Surveillance System (NNIS) of the CDC, our device utilization ratios and device-associated nosocomial infection rates were high. The main risk factors for bloodstream infection were birth weight [hazard ratio (HR) 1.79, 95% confidence interval (CI) 1.45-2.17] and parenteral feeding with hospital-pharmacy-produced, all-in-one mixture 'Minimix' (HR 3.69, 95%CI 2.03-6.69); administration of intravenous antibiotics (HR 0.39, 95%CI 0.26-0.56) was a protective risk factor. The

  12. 基于智能手机平台的环境噪声监测研究%Study on environmental noise monitoring by smart phone platform

    Institute of Scientific and Technical Information of China (English)

    李春明; 董仁才; 赵景柱

    2012-01-01

    This paper is inclined to provide a novel approach to the environmental noise monitoring, which can be taken as a new perspective for studying the environmental noise temporal-spatial distribution and environmental noise control and management. As we know, noise has now become one of the main urban environmental pollutants and the leading cause for people ' s environmental complaints , which is characteristic of large spatial difference, sudden occurrence and even a threat to the regular life and feelings. It is just from the above reasons that bring about the needs to monitor and control some serious spatial and temporal noise sources. And one of such noise sources is the over- popularized intelligent devices ( such as mobile phones, digital cameras, personal computers, etc.) . Aiming to satisfy the need to control, we have developed an environmental noise monitoring system based on a smart phone platform by analyzing the method of environmental noise monitoring and assessment. The so-called smart phone platform is calibrated by means of a real-time noise measure instrument (HS5633T) in the noise-producing field. The platform can acquire and register the actual noise level, the monitoring time, the coordinates of the monitoring sites, in addition to people' s senses to it. And, then, the smart phone platform can record the monitoring results and let its user to share the information and data of the noise with his friends or uploaded to the digital center. Finally, we have chosen Gulangyu, Xiamen, as a study case. The results of our trial use prove that the platform could be used to distinguish the levels of different noise-producing sources, to obtain the coordinates of monitoring sites and the noise-receivers' feelings and to share the monitoring results with his friends and the digital center in real-time instance. It is believed that the noise monitoring by using our device can both reduce the threshold of the noise monitoring level, allowing citizens to

  13. Multi –Media Educational Communication Strategies for English. A Case Study of an Online Chat Room for EFL as Platform of Applied Language Learning

    Directory of Open Access Journals (Sweden)

    Fee-Alexandra HASSE

    2012-08-01

    Full Text Available This paper is part of a cross-cultural study on the difficulties of English dialogues between non-native speakers in a special context where both sides share different linguistic and cultural backgrounds. The paper describes the characteristics of online dialogues by multiple-participants quantitatively comparing them with conditions of non-online dialogue criteria. Everyday communicative activities involve not only two-participant communicative situations, but also those of more than two-dialogue partners. A chat room can serve as a platform for such situations with speech communication. The first part of this paper introduces a general methodology for the development and study of conversational learning process. Our research is interested in a demonstration how online communication can be integrated into a classroom for EFL learning.

  14. Screening for copy-number alterations and loss of heterozygosity in chronic lymphocytic leukemia--a comparative study of four differently designed, high resolution microarray platforms

    DEFF Research Database (Denmark)

    Gunnarsson, R.; Staaf, J.; Jansson, M.;

    2008-01-01

    Screening for gene copy-number alterations (CNAs) has improved by applying genome-wide microarrays, where SNP arrays also allow analysis of loss of heterozygozity (LOH). We here analyzed 10 chronic lymphocytic leukemia (CLL) samples using four different high-resolution platforms: BAC arrays (32K...... detection. Evaluation of baseline variation and copy-number ratio response showed the best performance for the Agilent platform and confirmed the robustness of BAC arrays. Accordingly, these platforms demonstrated a higher degree of platform-specific CNAs. The SNP arrays displayed higher technical variation...

  15. USA Hire Testing Platform

    Data.gov (United States)

    Office of Personnel Management — The USA Hire Testing Platform delivers tests used in hiring for positions in the Federal Government. To safeguard the integrity of the hiring processes and ensure...

  16. MULTIFUNCTIONAL PLATFORMS AND

    African Journals Online (AJOL)

    Solar service centres and multifunctional platforms are innovative concepts for providing energy services in ... same time generate income. obeng ..... communities the driving force behind the ... operator(s) had to contact repairers outside their.

  17. The Common HOL Platform

    Directory of Open Access Journals (Sweden)

    Mark Adams

    2015-07-01

    Full Text Available The Common HOL project aims to facilitate porting source code and proofs between members of the HOL family of theorem provers. At the heart of the project is the Common HOL Platform, which defines a standard HOL theory and API that aims to be compatible with all HOL systems. So far, HOL Light and hol90 have been adapted for conformance, and HOL Zero was originally developed to conform. In this paper we provide motivation for a platform, give an overview of the Common HOL Platform's theory and API components, and show how to adapt legacy systems. We also report on the platform's successful application in the hand-translation of a few thousand lines of source code from HOL Light to HOL Zero.

  18. The Creative Platform

    DEFF Research Database (Denmark)

    Byrge, Christian; Hansen, Søren

    whether you consider thirdgrade teaching, human-resource development, or radical new thinking in product development in a company. The Creative Platform was developed at Aalborg University through a series of research-and-development activities in collaboration with educational institutions and private......This book is about introducing more creativity into general educational courses and cross-disciplinary activities. It is directed toward teachers at all levels in the educational system, but the Creative Platform is a general model, and thus the creative process will fundamentally be the same...... companies. It is a project in which the goal is to make a hands-on approach to a knowledge perspective on enhancing creativity. The underlying ambition of the Creative Platform is to make it easier to promote creativity. At www.uka.aau.dk/The+Creative+Platform, you can find extra materials and instructions...

  19. Predicting Droplet Formation on Centrifugal Microfluidic Platforms

    Science.gov (United States)

    Moebius, Jacob Alfred

    Centrifugal microfluidics is a widely known research tool for biological sample and water quality analysis. Currently, the standard equipment used for such diagnostic applications include slow, bulky machines controlled by multiple operators. These machines can be condensed into a smaller, faster benchtop sample-to-answer system. Sample processing is an important step taken to extract, isolate, and convert biological factors, such as nucleic acids or proteins, from a raw sample to an analyzable solution. Volume definition is one such step. The focus of this thesis is the development of a model predicting monodispersed droplet formation and the application of droplets as a technique for volume definition. First, a background of droplet microfluidic platforms is presented, along with current biological analysis technologies and the advantages of integrating such technologies onto microfluidic platforms. Second, background and theories of centrifugal microfluidics is given, followed by theories relevant to droplet emulsions. Third, fabrication techniques for centrifugal microfluidic designs are discussed. Finally, the development of a model for predicting droplet formation on the centrifugal microfluidic platform are presented for the rest of the thesis. Predicting droplet formation analytically based on the volumetric flow rates of the continuous and dispersed phases, the ratios of these two flow rates, and the interfacial tension between the continuous and dispersed phases presented many challenges, which will be discussed in this work. Experimental validation was completed using continuous phase solutions of different interfacial tensions. To conclude, prospective applications are discussed with expected challenges.

  20. A Prospective, Multicenter Study of Complementary/Alternative Medicine (CAM) Utilization During Definitive Radiation for Breast Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Moran, Meena S., E-mail: meena.moran@yale.edu [Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut (United States); Department of Radiation Therapy, William W. Backus Hospital, Norwich, Connecticut (United States); Ma Shuangge [Department of Epidemiology and Public Health, Yale University, New Haven, Connecticut (United States); Jagsi, Reshma [University of Michigan, Department of Radiation Oncology, Ann Arbor, MI (United States); Yang, Tzu-I Jonathan [Yale University School of Medicine, New Haven, Connecticut (United States); Higgins, Susan A. [Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut (United States); Department of Radiation Therapy, Shoreline Medical Center, Guilford, Connecticut (United States); Weidhaas, Joanne B. [Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut (United States); Wilson, Lynn D. [Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut (United States); Department of Radiation Therapy, Lawrence and Memorial Hospital, New London, Connecticut (United States); Lloyd, Shane [Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut (United States); Peschel, Richard [Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut (United States); Department of Radiation Therapy, Lawrence and Memorial Hospital, New London, Connecticut (United States); Gaudreau, Bryant [Department of Radiation Therapy, William W. Backus Hospital, Norwich, Connecticut (United States); Rockwell, Sara [Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut (United States)

    2013-01-01

    Purpose: Although complementary and alternative medicine (CAM) utilization in breast cancer patients is reported to be high, there are few data on CAM practices in breast patients specifically during radiation. This prospective, multi-institutional study was conducted to define CAM utilization in breast cancer during definitive radiation. Materials/Methods: A validated CAM instrument with a self-skin assessment was administered to 360 Stage 0-III breast cancer patients from 5 centers during the last week of radiation. All data were analyzed to detect significant differences between users/nonusers. Results: CAM usage was reported in 54% of the study cohort (n=194/360). Of CAM users, 71% reported activity-based CAM (eg, Reiki, meditation), 26% topical CAM, and 45% oral CAM. Only 16% received advice/counseling from naturopathic/homeopathic/medical professionals before initiating CAM. CAM use significantly correlated with higher education level (P<.001), inversely correlated with concomitant hormone/radiation therapy use (P=.010), with a trend toward greater use in younger patients (P=.066). On multivariate analysis, level of education (OR: 6.821, 95% CI: 2.307-20.168, P<.001) and hormones/radiation therapy (OR: 0.573, 95% CI: 0.347-0.949, P=.031) independently predicted for CAM use. Significantly lower skin toxicity scores were reported in CAM users vs nonusers, respectively (mild: 34% vs 25%, severe: 17% vs 29%, P=.017). Conclusion: This is the first prospective study to assess CAM practices in breast patients during radiation, with definition of these practices as the first step for future investigation of CAM/radiation interactions. These results should alert radiation oncologists that a large percentage of breast cancer patients use CAM during radiation without disclosure or consideration for potential interactions, and should encourage increased awareness, communication, and documentation of CAM practices in patients undergoing radiation treatment for breast