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Sample records for plate mcp detector

  1. Single ion counting with a MCP (microchannel plate) detector

    Energy Technology Data Exchange (ETDEWEB)

    Tawara, Hiroko; Sasaki, Shinichi; Miyajima, Mitsuhiro [National Lab. for High Energy Physics, Tsukuba, Ibaraki (Japan); Shibamura, Eido

    1996-07-01

    In this study, a single-ion-counting method using alpha-particle-impact ionization of Ar atoms is demonstrated and the preliminary {epsilon}{sub mcp} for Ar ions with incident energies of 3 to 4.7 keV is determined. The single-ion counting by the MCP is aimed to be performed under experimental conditions as follows: (1) A signal from the MCP is reasonably identified as incidence of single Ar-ion. (2) The counting rate of Ar ions is less than 1 s{sup -1}. (3) The incident Ar ions are not focused on a small part of an active area of the MCP, namely, {epsilon}{sub mcp} is determined with respect to the whole active area of the MCP. So far, any absolute detection efficiency has not been reported under these conditions. (J.P.N.)

  2. Development of a new fast shower maximum detector based on microchannel plates photomultipliers (MCP-PMT) as an active element

    Energy Technology Data Exchange (ETDEWEB)

    Ronzhin, A., E-mail: ronzhin@fnal.gov [Fermilab, Batavia, IL 60510 (United States); Los, S.; Ramberg, E. [Fermilab, Batavia, IL 60510 (United States); Spiropulu, M.; Apresyan, A.; Xie, S. [California Institute of Technology, Pasadena, CA (United States); Kim, H. [University of Chicago, Chicago, IL 60637 (United States); Zatserklyaniy, A. [University of California, Santa Cruz, CA (United States)

    2014-09-21

    One possibility to make a fast and radiation resistant shower maximum (SM) detector is to use a secondary emitter as an active element. We present below test beam results, obtained with different types of photodetectors based on microchannel plates (MCPs) as the secondary emitter. We performed the measurements at the Fermilab Test Beam Facility with 120 GeV proton beam and 12 GeV and 32 GeV secondary beams. The goal of the measurement with 120 GeV protons was to determine time resolution for minimum ionizing particles (MIPs). The SM time resolution we obtained for this new type of detector is at the level of 20–30 ps. We estimate that a significant contribution to the detector response originates from secondary emission of the MCP. This work can be considered as the first step in building a new type of calorimeter based on this principle.

  3. Ion Feedback Suppression Using Inclined MCP Holes in a Single-MCP+Micromegas+Pads Detector

    International Nuclear Information System (INIS)

    Va'vra, J.; Sumiyoshi, T.

    2005-01-01

    We show that the ion backflow to photocathode can be completely suppressed if one uses inclined MCP holes in a presence of magnetic field. The inclined hole angles are chosen to be aligned with the Lorentz electron angle allowing the electron transmission and amplification, while positive ions, traveling along a different angle, are caught on the MCP hole walls. The detector under investigation is a new gaseous detector structure based on a tandem of two parts, a single MCP (Microchannel) plate, a Micromegas with pad readout. We are aiming to develop a gaseous photon detector with the Bialkali photocathode, however, one could use some ideas in the paper for other types of detectors

  4. Ion feedback suppression using inclined MCP holes in a 'single-MCP+micromegas+pads' detector

    International Nuclear Information System (INIS)

    Va'vra, J.; Sumiyoshi, T.

    2005-01-01

    We show that the ion backflow to photocathode can be completely suppressed if one uses inclined MCP holes in the presence of a magnetic field. The inclined hole angles are chosen to be aligned with the Lorentz electron angle allowing the electron transmission and amplification, while positive ions, traveling along a different angle, are caught on the MCP hole walls. The detector under investigation is a new gaseous detector structure based on a tandem of two parts, a single MCP (microchannel plate), a micromegas with pad readout. We are aiming to develop a gaseous photon detector with the Bialkali photocathode, however, one could use some ideas in the paper for other types of detectors

  5. Monte Carlo Simulations of High-speed, Time-gated MCP-based X-ray Detectors: Saturation Effects in DC and Pulsed Modes and Detector Dynamic Range

    International Nuclear Information System (INIS)

    Kruschwitz, Craig; Ming Wu; Moy, Ken; Rochau, Greg

    2008-01-01

    We present here results of continued efforts to understand the performance of microchannel plate (MCP)-based, high-speed, gated, x-ray detectors. This work involves the continued improvement of a Monte Carlo simulation code to describe MCP performance coupled with experimental efforts to better characterize such detectors. Our goal is a quantitative description of MCP saturation behavior in both static and pulsed modes. We have developed a new model of charge buildup on the walls of the MCP channels and measured its effect on MCP gain. The results are compared to experimental data obtained with a short-pulse, high-intensity ultraviolet laser; these results clearly demonstrate MCP saturation behavior in both DC and pulsed modes. The simulations compare favorably to the experimental results. The dynamic range of the detectors in pulsed operation is of particular interest when fielding an MCP-based camera. By adjusting the laser flux we study the linear range of the camera. These results, too, are compared to our simulations

  6. Developments in microchannel plate detectors for imaging x-ray astronomy

    International Nuclear Information System (INIS)

    Fraser, G.W.; Whiteley, M.J.; Pearson, J.F.

    1985-01-01

    The authors present new results in four areas of microchannel plate (MCP) X-ray detector operation. The performance in pulse counting mode of MCPs with 8 micron channel diameters is reported. The effects on MCP quantum detection efficiency and energy discrimination of multiple CsI coatings are described. A new mode of operation of two-stage multipliers is evaluated. Replacing the conventional electron-accelerating inter-plate potential difference by a retarding field is shown to result in definite advantages with regard to X-ray energy discrimination and detector lifetime. The source of the MCP internal background is discussed

  7. Readout for a large area neutron sensitive microchannel plate detector

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Yiming [Department of Engineering Physics, Tsinghua University, Beijing (China); Key Laboratory of Particle & Radiation Imaging, Tsinghua University, Ministry of Education, Beijing (China); Yang, Yigang, E-mail: yangyigang@mail.tsinghua.edu.cn [Department of Engineering Physics, Tsinghua University, Beijing (China); Key Laboratory of Particle & Radiation Imaging, Tsinghua University, Ministry of Education, Beijing (China); Wang, Xuewu; Li, Yuanjing [Department of Engineering Physics, Tsinghua University, Beijing (China); Key Laboratory of Particle & Radiation Imaging, Tsinghua University, Ministry of Education, Beijing (China)

    2015-06-01

    A neutron sensitive microchannel plate (MCP) detector was developed for neutron imaging on the beamline of a compact pulsed hadron source (CPHS). The detector was set up with a Wedge-and-Strip Anode (WSA) and a delay line anode readout to compare the spatial resolution and throughput with these two anodes. Tests show that the WSA readout is suitable for small area imaging with a spatial resolution of 200 μm with low energy X-rays in a 50 mm diameter MCP–WSA assembly. However, the spatial resolution deteriorated to ~2 mm in a 106 mm diameter MCP–WSA assembly because the noise caused by the parasitic capacitance is 10 times larger in the larger assembly than in the 50 mm diameter assembly. A 120 mm by 120 mm delay line anode was then used for the 106 mm MCP readout. The spatial resolution was evaluated for various voltages applied to the MCP V-stack, various readout voltages and various distances between the MCP V-stack rear face and the delay line. The delay line readout had resolutions of 65.6 μm in the x direction and 63.7 μm in the y direction and the throughput was greater than 600 kcps. The MCP was then used to acquire a neutron image of an USAF1951 Gd-mask.

  8. Development and tests of MCP based timing and multiplicity detector for MIPs

    Science.gov (United States)

    Feofilov, G.; Kondratev, V.; Stolyarov, O.; Tulina, T.; Valiev, F.; Vinogradov, L.

    2017-01-01

    We present summary of technological developments and tests of the MCP based large area detector aimed at precise timing and charged particles multiplicity measurements. Results obtained in course of these developments of isochronous (simultaneity) precise signal readout, passive summation of 1 ns signals, fast (1 GHz) front-end electronics, miniature vacuum systems, etc. could be potentially interesting for a number of future applications in different fields.

  9. Parallel plate detectors

    International Nuclear Information System (INIS)

    Gardes, D.; Volkov, P.

    1981-01-01

    A 5x3cm 2 (timing only) and a 15x5cm 2 (timing and position) parallel plate avalanche counters (PPAC) are considered. The theory of operation and timing resolution is given. The measurement set-up and the curves of experimental results illustrate the possibilities of the two counters [fr

  10. Measurement of 2-5 keV x-ray emission from laser-target interactions by using fluor-MCP and CsI-XRD detectors

    International Nuclear Information System (INIS)

    Lee, P.H.Y.; Tirsell, K.G.; Leipelt, G.R.; Laird, W.B.

    1981-01-01

    For inertial confinement fusion plasma diagnostics, x-ray diode (XRD) detectors using conventional cathodes are not sensitive enough to measure x-rays above approx. 1.5 keV. However, for laser driver fusion targets, x-rays in the range of 2 to 5 keV are important because of their mobility in the target. We have successfully used fluor-microchannel plate (MCP) detectors to obtain absolute x-ray measurements in the 2 to 5 keV range. Recent data obtained from experiments on the Shiva laser system are presented. In addition, designs for a variety of channels in the range using fluor-MCP and CsI-XRD's above 1.5 keV will be discussed

  11. Studies of MCP properties

    International Nuclear Information System (INIS)

    Lehmann, A; Britting, A; Eyrich, W; Uhlig, F

    2009-01-01

    Cherenkov detectors of the DIRC type will be used for the particle identification of the PANDA experiment at FAIR. Because of their advantageous properties inside a magnetic field micro-channel plate (MCP) photomultipliers (PMT) are very attractive photon sensors for the two PANDA DIRCs. Various types of MCP-PMTs were investigated. Their gains and their time resolutions were measured as a function of the magnitude and the direction of a magnetic field. It was found that with a pore size of ≤ 10 μm efficient single photon detection is possible even at 2 Tesla if the field direction is close to parallel to the PMT axis. The gain of most of the studied MCP-PMTs remains stable up to a photon density of roughly 1 MHz/cm 2 , while the new Hamamatsu R10754-00-L4 can stand rates of about 10 MHz/cm 2 before the gain starts decreasing. The time resolution of all investigated MCP-PMTs was better than 50 ps (σ). The response of the multi-anode MCP-PMTs was scanned as a function of the position of the photo cathode plane in particular to measure the crosstalk among adjacent pixels. Most of the sensors show a satisfactory behavior.

  12. Time response of fast-gated microchannel plates used as x-ray detectors

    International Nuclear Information System (INIS)

    Turner, R.E.; Bell, P.; Hanks, R.; Kilkenny, J.D.; Landen, N.; Power, G.; Wiedwald, J.; Meier, M.

    1990-01-01

    We report measurements of the time response of fast-gated, micro- channel plate (MCP) detectors, using a <10 ps pulsewidth ultra-violet laser and an electronic sampling system to measure time resolutions to better than 25 ps. The results show that framing times of less than 100 ps are attainable with high gain. The data is compared to a Monte Carlo calculation, which shows good agreement. We also measured the relative sensitivity as a function of DC bias, and saturation effects for large signal inputs. In part B, we briefly describe an electrical ''time-of-flight'' technique, which we have used to measure the response time of a fast-gated microchannel plate (MCP). Thinner MCP's than previously used have been tested, and, as expected, show fast gating times and smaller electron multiplication. A preliminary design for an x-ray pinhole camera, using a thin MCP, is presented. 7 refs., 6 figs

  13. MCP detector read out with a bare quad Timepix at kilohertz frame rates

    International Nuclear Information System (INIS)

    Vallerga, J; Tremsin, A; McPhate, J; Siegmund, O; Raffanti, R

    2011-01-01

    The existing Berkeley neutron sensitive MCP/Timepix hybrid detector has been very successful at demonstrating energy resolved spatial imaging with a single Timepix ASIC read out at a ∼ 30 Hz frame rate where each neutron's position and time (energy) is determined (X,Y,E). By increasing the detector format using a quad arrangement of Timepix readouts and increasing the frame rate to 1 kHz, we can increase our total event throughput by a factor of 120, thereby taking full advantage of the high fluxes of modern pulsed neutron sources (10 6 n cm -2 s -1 ). The key to this conversion is a new design for the ASIC readout, called the Berkeley Quad Timepix detector, consisting of 3 major subsystems. The first is a quad (2 x 2) bare Timepix ASIC board mounted directly behind the neutron sensitive MCPs in a hermetic vacuum enclosure with a sapphire window. The data from the Timepix ASICs flow to the second subsystem called the Interface board whose field programmable gate array (FPGA) rearranges and converts the digital bit stream to LVDS logic levels before sending downstream to the third subsystem, the Roach board. The Roach board is also FPGA based, and takes the data from all the ASICs and analyses the frames to extract information on the input events to pass on to the host PC. This paper describes in detail the hardware and firmware designs to accomplish this task.

  14. Mean secondary electron yield of avalanche electrons in the channels of a microchannel plate detector

    International Nuclear Information System (INIS)

    Funsten, H.O.; Suszcynsky, D.M.; Harper, R.W.

    1996-01-01

    By modeling the statistical evolution of an avalanche created by 20 keV protons impacting the input surface of a z-stack microchannel plate (MCP) detector, the mean secondary electron yield γ C of avalanche electrons propagating through a MCP channel is measured to equal 1.37 for 760 V per MCP in the z stack. This value agrees with other studies that used MCP gain measurements to infer γ C . The technique described here to measure γ C is independent of gain saturation effects and simplifying assumptions used in the segmented dynode model, both of which can introduce errors when inferring γ C through gain measurements. copyright 1996 American Institute of Physics

  15. Experimental evaluation of the response of micro-channel plate detector to ions with 10s of MeV energies

    International Nuclear Information System (INIS)

    Jeong, Tae Won; Ter-Avetisyan, S.; Singh, P. K.; Kakolee, K. F.; Scullion, C.; Ahmed, H.; Hadjisolomou, P.; Alejo, A.; Kar, S.; Borghesi, M.

    2016-01-01

    The absolute calibration of a microchannel plate (MCP) assembly using a Thomson spectrometer for laser-driven ion beams is described. In order to obtain the response of the whole detection system to the particles’ impact, a slotted solid state nuclear track detector (CR-39) was installed in front of the MCP to record the ions simultaneously on both detectors. The response of the MCP (counts/particles) was measured for 5–58 MeV carbon ions and for protons in the energy range 2–17.3 MeV. The response of the MCP detector is non-trivial when the stopping range of particles becomes larger than the thickness of the detector. Protons with energies E ≳ 10 MeV are energetic enough that they can pass through the MCP detector. Quantitative analysis of the pits formed in CR-39 and the signal generated in the MCP allowed to determine the MCP response to particles in this energy range. Moreover, a theoretical model allows to predict the response of MCP at even higher proton energies. This suggests that in this regime the MCP response is a slowly decreasing function of energy, consistently with the decrease of the deposited energy. These calibration data will enable particle spectra to be obtained in absolute terms over a broad energy range.

  16. Experimental evaluation of the response of micro-channel plate detector to ions with 10s of MeV energies

    Science.gov (United States)

    Jeong, Tae Won; Singh, P. K.; Scullion, C.; Ahmed, H.; Kakolee, K. F.; Hadjisolomou, P.; Alejo, A.; Kar, S.; Borghesi, M.; Ter-Avetisyan, S.

    2016-08-01

    The absolute calibration of a microchannel plate (MCP) assembly using a Thomson spectrometer for laser-driven ion beams is described. In order to obtain the response of the whole detection system to the particles' impact, a slotted solid state nuclear track detector (CR-39) was installed in front of the MCP to record the ions simultaneously on both detectors. The response of the MCP (counts/particles) was measured for 5-58 MeV carbon ions and for protons in the energy range 2-17.3 MeV. The response of the MCP detector is non-trivial when the stopping range of particles becomes larger than the thickness of the detector. Protons with energies E ≳ 10 MeV are energetic enough that they can pass through the MCP detector. Quantitative analysis of the pits formed in CR-39 and the signal generated in the MCP allowed to determine the MCP response to particles in this energy range. Moreover, a theoretical model allows to predict the response of MCP at even higher proton energies. This suggests that in this regime the MCP response is a slowly decreasing function of energy, consistently with the decrease of the deposited energy. These calibration data will enable particle spectra to be obtained in absolute terms over a broad energy range.

  17. Experimental evaluation of the response of micro-channel plate detector to ions with 10s of MeV energies

    Energy Technology Data Exchange (ETDEWEB)

    Jeong, Tae Won; Ter-Avetisyan, S. [Center for Relativistic Laser Science, Institute of Basic Science (IBS), Gwangju 61005 (Korea, Republic of); Department of Physics and Photon Science, Gwangju Institute of Science and Technology (GIST), Gwangju 61005 (Korea, Republic of); Singh, P. K.; Kakolee, K. F. [Center for Relativistic Laser Science, Institute of Basic Science (IBS), Gwangju 61005 (Korea, Republic of); Scullion, C.; Ahmed, H.; Hadjisolomou, P.; Alejo, A.; Kar, S.; Borghesi, M. [School of Mathematics and Physics, The Queen’s University of Belfast, Belfast BT7 1NN (United Kingdom)

    2016-08-15

    The absolute calibration of a microchannel plate (MCP) assembly using a Thomson spectrometer for laser-driven ion beams is described. In order to obtain the response of the whole detection system to the particles’ impact, a slotted solid state nuclear track detector (CR-39) was installed in front of the MCP to record the ions simultaneously on both detectors. The response of the MCP (counts/particles) was measured for 5–58 MeV carbon ions and for protons in the energy range 2–17.3 MeV. The response of the MCP detector is non-trivial when the stopping range of particles becomes larger than the thickness of the detector. Protons with energies E ≳ 10 MeV are energetic enough that they can pass through the MCP detector. Quantitative analysis of the pits formed in CR-39 and the signal generated in the MCP allowed to determine the MCP response to particles in this energy range. Moreover, a theoretical model allows to predict the response of MCP at even higher proton energies. This suggests that in this regime the MCP response is a slowly decreasing function of energy, consistently with the decrease of the deposited energy. These calibration data will enable particle spectra to be obtained in absolute terms over a broad energy range.

  18. TOF-SIMA analysis of coating on MCP

    International Nuclear Information System (INIS)

    Luo Chunping; Liang Handong; Sun Dongxu

    2007-01-01

    Microchannel plate (MCP) is a sophisticated electronic optical device. It has advantages of high gain, small size, and low using voltage as a detector. The electronic transmission film on the MCP input plane could effectively avoid the positive ion feedback, and protect the photocathode, eliminate flicker noise, and prolong the lifespan of the device. In conclusion, the different films of the input plane can affect the performance of the MCP. Therefore, there is practical value to study surface coating composition of MCP for understanding the relationship between composition and performance and developing high-powered MCP. In the experiment, TOF-SIMS is used to study the surface coating composition of MCP. The results show that there are some main metal elements such as Si, K, Cr, Ni, Rh, Cs and Pb in the surface of the MCP. (authors)

  19. Monte Carlo simulations of microchannel plate detectors I: steady-state voltage bias results

    Energy Technology Data Exchange (ETDEWEB)

    Ming Wu, Craig Kruschwitz, Dane Morgan, Jiaming Morgan

    2008-07-01

    X-ray detectors based on straight-channel microchannel plates (MCPs) are a powerful diagnostic tool for two-dimensional, time-resolved imaging and timeresolved x-ray spectroscopy in the fields of laser-driven inertial confinement fusion and fast z-pinch experiments. Understanding the behavior of microchannel plates as used in such detectors is critical to understanding the data obtained. The subject of this paper is a Monte Carlo computer code we have developed to simulate the electron cascade in a microchannel plate under a static applied voltage. Also included in the simulation is elastic reflection of low-energy electrons from the channel wall, which is important at lower voltages. When model results were compared to measured microchannel plate sensitivities, good agreement was found. Spatial resolution simulations of MCP-based detectors were also presented and found to agree with experimental measurements.

  20. Efficiency enhancements for MCP-based beta autoradiography imaging

    CERN Document Server

    Lees, J E

    2002-01-01

    We describe three approaches to increase the beta detection efficiency of microchannel plate detectors for biological beta autoradiography:(a)reversing the microchannel plate (MCP) bias polarity, changing the conventional high negative voltage on the input MCP to a grounded input, (b) a reduction in MCP pore size from 12.5 to 6 mu m, (c) using a CsI coating as an efficient secondary electron emitter. We also present our first measurements of double-tracer ( sup 3 H and sup 1 sup 4 C) imaging using pulse height analysis to distinguish between isotopes.

  1. Applications of 'edge-on' illuminated porous plate detectors for diagnostic X-ray imaging

    CERN Document Server

    Shikhaliev, P M

    2002-01-01

    Scanning X-ray imaging systems for non-invasive diagnostics have several advantages over conventional imaging systems using area detectors. They significantly reduce the detected scatter radiation, cover large areas and potentially provide high spatial resolution. Applications of one-dimensional gaseous detectors and 'edge-on' illuminated silicon strip detectors for scanning imaging systems are currently under intensive investigation. The purpose of this work is to investigate 'edge-on' illuminated Porous Plate (PP) detectors for applications in diagnostic X-ray imaging. MicroChannel Plate (MCP), which is a common type of PP, has previously been investigated as a detector in surface-on illumination mode for medical X-ray imaging. However, its detection efficiency was too low for medical imaging applications. In the present study, the PP are used in the 'edge-on' illumination mode. Furthermore, the structural parameters of different PP types are optimized to improve the detection efficiency in the diagnostic X...

  2. An efficient and cost-effective microchannel plate detector for slow neutron radiography

    Science.gov (United States)

    Wiggins, B. B.; Vadas, J.; Bancroft, D.; deSouza, Z. O.; Huston, J.; Hudan, S.; Baxter, D. V.; deSouza, R. T.

    2018-05-01

    A novel approach for efficiently imaging objects with slow neutrons in two dimensions is realized. Neutron sensitivity is achieved by use of a boron doped microchannel plate (MCP). The resulting electron avalanche is further amplified with a Z-stack MCP before being sensed by two orthogonally oriented wire planes. Coupling of the wire planes to delay lines efficiently encodes the position information as a time difference. To determine the position resolution, slow neutrons were used to illuminate a Cd-mask placed directly in front of the detector. Peaks in the resulting spectrum exhibited an average peak width of 329 μm FWHM, corresponding to an average intrinsic resolution of 216 μm. The center region of the detector exhibits a significantly better spatial resolution with an intrinsic resolution of <100 μm observed.

  3. Fast microchannel plate detector for particles

    International Nuclear Information System (INIS)

    Wurz, P.; Gubler, L.

    1996-01-01

    In this article we report on the timing capabilities of a new microchannel plate detector we designed and built. The detector assembly has an impedance-matched transition line (50 Ω line resistance) from anode to cable connector which is considerably smaller than other, commercially available solutions and at the same time has about four times the active area. The detector was tested with an alpha particle source and excellent time response was achieved. Using 10 μm pore size channel plates, a rise time of 300 ps and a pulse width of 520 ps are obtained. The details of the signal analysis are also given in the article. copyright 1996 American Institute of Physics

  4. Coordinate sensitive detectors based on microchannel plates

    International Nuclear Information System (INIS)

    Gruntman, M.A.

    1984-01-01

    Coordinate-sensitive detectors (CSD) on the basis of microchannel plates permit to determine in a digital form the coordinates of every recorded particle and they are used in different fields of physical experiment. The sensitive surface diameter of such detectors can reach 10 cm, and spatial resolution - 10 μm. In the review provided CSD with microchannel plates are classified according to the ways of coordinate determination, different types of the detectors, pecUliarities of their design and electron flowsheet are described. It is pointed out that there are reasons for introduction of CSD into practice of laboratory physical investigations in various fields, where the particle recorded is electron or is able to form a secondary electron. It is attributed to nuclear physics, physics of electron and atom collisions, optics, mass-spectrometry, electron microscopy, X-ray analysis, investigation of surfaces

  5. Examination of the spatial-response uniformity of a microchannel-plate detector using a pulsed high-voltage electron gun

    International Nuclear Information System (INIS)

    Alumot, D; Kroupp, E; Fisher, A

    2014-01-01

    In this paper we describe an alternative method to examine the spatial-response uniformity of a microchannel-plate (MCP) detector to a ∼ 1 ns pulse of soft x-rays. The examination was performed by illuminating the MCP surface with energetic electrons rather than with x-rays. It is shown that the MCP features similar, yet not identical, response to pulses of soft x-ray photons or energetic electrons, making such examinations much simpler and less expensive. The building of the electron-gun system is relatively easy and inexpensive, and in addition to verifying the spatial uniformity of the response of the MCP to incoming particles and radiation, it can be used to detect damaged areas on the detector. A comparison between the results obtained using the electron-gun with those obtained using a laser-produced-plasma x-ray source, demonstrating the reliability of the method, is presented

  6. Micro-channel plates and vacuum detectors

    Energy Technology Data Exchange (ETDEWEB)

    Gys, T., E-mail: Thierry.Gys@cern.ch

    2015-07-01

    A micro-channel plate is an array of miniature electron multipliers that are each acting as a continuous dynode chain. The compact channel structure results in high spatial and time resolutions and robustness to magnetic fields. Micro-channel plates have been originally developed for night vision applications and integrated as an amplification element in image intensifiers. These devices show single-photon sensitivity with very low noise and have been used as such for scintillating fiber tracker readout in high-energy physics experiments. Given their very short transit time spread, micro-channel plate photomultiplier tubes are also being used in time-of-flight and particle identification detectors. The present paper will cover the history of the micro-channel plate development, basic features, and some of their applications. Emphasis will be put on various new manufacturing processes that have been developed over the last few years, and that result in a significant improvement in terms of efficiency, noise, and lifetime performance.

  7. Detector Physics of Resistive Plate Chambers

    CERN Document Server

    Lippmann, Christian; Riegler, W

    2003-01-01

    Resistive Plate Chambers (RPCs) are gaseous parallel plate avalanche detectors that implement electrodes made from a material with a high volume resistivity between 10^7 and 10^12 Ohm cm. Large area RPCs with 2mm single gaps operated in avalanche mode provide above 98% efficiency and a time resolution of around 1ns up to a flux of several kHz/cm2. These Trigger RPCs will, as an example, equip the muon detector system of the ATLAS experiment at CERN on an area of 3650m2 and with 355.000 independent read out channels. Timing RPCs with a gas gap of 0.2 to 0.3mm are widely used in multi gap configurations and provide 99% efficiency and time resolution down to 50ps. While their performance is comparable to existing scintillator-based Time-Of-Flight (TOF) technology, Timing RPCs feature a significantly, up to an order of magnitude, lower price per channel. They will for example equip the 176m2 TOF barrel of the ALICE experiment at CERN with 160.000 independent read out cells. RPCs were originally operated in stream...

  8. Microchannel plate detector technology potential for LUVOIR and HabEx

    Science.gov (United States)

    Siegmund, O. H. W.; Ertley, C.; Vallerga, J. V.; Schindhelm, E. R.; Harwit, A.; Fleming, B. T.; France, K. C.; Green, J. C.; McCandliss, S. R.; Harris, W. M.

    2017-08-01

    Microchannel plate (MCP) detectors have been the detector of choice for ultraviolet (UV) instruments onboard many NASA missions. These detectors have many advantages, including high spatial resolution (hardness, large formats (up to 20 cm), and ability for curved focal plane matching. Novel borosilicate glass MCPs with atomic layer deposition combine extremely low backgrounds, high strength, and tunable secondary electron yield. GaN and combinations of bialkali/alkali halide photocathodes show promise for broadband, higher quantum efficiency. Cross-strip anodes combined with compact ASIC readout electronics enable high spatial resolution over large formats with high dynamic range. The technology readiness levels of these technologies are each being advanced through research grants for laboratory testing and rocket flights. Combining these capabilities would be ideal for UV instruments onboard the Large UV/Optical/IR Surveyor (LUVOIR) and the Habitable Exoplanet Imaging Mission (HABEX) concepts currently under study for NASA's Astrophysics Decadal Survey.

  9. Tests of prototype magnets and study on a MCP based proton detector for the neutron lifetime experiment PENeLOPE

    International Nuclear Information System (INIS)

    Materne, Stefan

    2013-01-01

    The precision experiment PENeLOPE will store ultra-cold neutrons in a magnetic trap and determine the neutron lifetime via the time-resolved counting of the decay-protons. The thesis reports on training and performance tests of prototypes of the superconducting coils. Additionally, a magnetic field mapper for PENeLOPE was characterized. In the second part of the thesis, microchannel plates (MCPs) were studied with alpha particles and protons as a possible candidate for the decay particle detector in PENeLOPE.

  10. Micro-channel plate detector for ultra-fast relativistic electron diffraction

    International Nuclear Information System (INIS)

    Musumeci, P.; Moody, J.T.; Scoby, C.M.; Gutierrez, M.S.; Bender, H.A.; Hilko, B.; Kruschwitz, C.A.; Wilcox, N.S.

    2011-01-01

    Using relativistic ultra-short electron beams to obtain single-shot diffraction patterns holds the promise to yield real-time resolution of atomic motion in an easily accessible environment, such as a university laboratory, at a fraction of the cost of fourth-generation X-ray sources. One of the main issues in bringing this technique to full maturity is the development of efficient detector systems to record the diffraction pattern using a few MeV electron beams. Low noise, high spatial resolution, and single-electron detection capability are all characteristics of an ideal detector. In this paper, we compare the performances of a traditional fluorescent phosphor screen with a detection system based on the micro-channel plate (MCP). Since MCPs are typically used with lower energy electron beams, these tests constitute one of the few experimental data points available on the use of these devices with MeV energy beams.

  11. Micro-channel plate detector for ultra-fast relativistic electron diffraction

    Energy Technology Data Exchange (ETDEWEB)

    Musumeci, P., E-mail: musumeci@physics.ucla.edu [UCLA Department of Physics and Astronomy, 475 Portola Plaza, Los Angeles, CA, 90095-1547 (United States); Moody, J.T.; Scoby, C.M.; Gutierrez, M.S. [UCLA Department of Physics and Astronomy, 475 Portola Plaza, Los Angeles, CA, 90095-1547 (United States); Bender, H.A.; Hilko, B.; Kruschwitz, C.A.; Wilcox, N.S. [National Security Technologies, LLC, Los Alamos Operations, Los Alamos, NM (United States)

    2011-05-01

    Using relativistic ultra-short electron beams to obtain single-shot diffraction patterns holds the promise to yield real-time resolution of atomic motion in an easily accessible environment, such as a university laboratory, at a fraction of the cost of fourth-generation X-ray sources. One of the main issues in bringing this technique to full maturity is the development of efficient detector systems to record the diffraction pattern using a few MeV electron beams. Low noise, high spatial resolution, and single-electron detection capability are all characteristics of an ideal detector. In this paper, we compare the performances of a traditional fluorescent phosphor screen with a detection system based on the micro-channel plate (MCP). Since MCPs are typically used with lower energy electron beams, these tests constitute one of the few experimental data points available on the use of these devices with MeV energy beams.

  12. A Design of a PET Detector Using Micro-Channel Plate Photomultipliers with Transmission-Line Readout.

    Science.gov (United States)

    Kim, H; Frisch, H; Chen, C-T; Genat, J-F; Tang, F; Moses, W W; Choong, W S; Kao, C-M

    2010-01-01

    A computer simulation study has been conducted to investigate the feasibility of a positron emission tomography (PET) detector design by using micro-channel plate (MCP) photomultiplier tubes (PMT) with transmission-line (TL) read-out and waveform sampling. The detector unit consisted of a 24×24 array of pixelated LSO crystals, each of which was 4×4×25 mm(3) in size, and two 102×102 mm(2) MCP-PMTs coupled to both sides of the scintillator array. The crystal (and TL) pitch was 4.25 mm and reflective medium was inserted between the crystals. The transport of the optical photons inside the scintillator were simulated by using the Geant4 package. The output pulses of the MCP-PMT/TL unit were formed by applying the measured single photo-electron response of the MCP-PMT/TL unit to each individual photon that interacts with the photo-cathode of the MCP-PMT. The waveforms of the pulses at both ends of the TL strips were measured and analyzed to produce energy and timing information for the detected event. An experimental setup was developed by employing a Photonis Planacon MCP-PMT (XP85022) and a prototype TL board for measuring the single photo-electron response of the MCP-PMT/TL. The simulation was validated by comparing the predicted output pulses to measurements obtained with a single MCP-PMT/TL coupled to an LSO crystal exposed to 511 keV gamma rays. The validated simulation was then used to investigate the performance of the proposed new detector design. Our simulation result indicates an energy resolution of ~11% at 511 keV. When using a 400-600 keV energy window, we obtain a coincidence timing resolution of ~323 ps FWHM and a coincidence detection efficiency of ~40% for normally-incident 511keV photons. For the positioning accuracy, it is determined by the pitch of the TLs (and crystals) in the direction normal to the TLs and measured to be ~2.5 mm in the direction parallel to the TLs. The energy and timing obtained at the front- and back-end of the scintillator

  13. Single electron counting using a dual MCP assembly

    International Nuclear Information System (INIS)

    Yang, Yuzhen; Liu, Shulin; Zhao, Tianchi; Yan, Baojun; Wang, Peiliang; Yu, Yang; Lei, Xiangcui; Yang, Luping; Wen, Kaile; Qi, Ming

    2016-01-01

    The gain, pulse height resolution and peak-to-valley ratio of single electrons detected by using a Chevron configured Microchannel Plate (MCP) assembly are studied. The two MCPs are separated by a 280 µm gap and are biased by four electrodes. The purpose of the study is to determine the optimum bias voltage arrangements for single electron counting. By comparing the results of various bias voltage combinations, we conclude that good performance for the electron counting can be achieved by operating the MCP assembly in saturation mode. In addition, by applying a small reverse bias voltage across the gap while adjusting the bias voltages of the MCPs, optimum performance of electron counting can be obtained. - Highlights: • Dual MCPs assembly with four electrodes using different voltage combinations has been investigated for single electron counting. • Both the MCP voltages and the gap voltage can affect the gain, pulse height resolution and P/V ratio. • A high gain of the first stage MCP, a saturation mode of the second stage MCP and an appropriately reverse gap voltage can improve the resolution greatly. • The optimum voltage arrangements is significant for the design of MCP detectors in single electron counting applications.

  14. Batch production of microchannel plate photo-multipliers

    Energy Technology Data Exchange (ETDEWEB)

    Frisch, Henry J.; Wetstein, Matthew; Elagin, Andrey

    2018-03-06

    In-situ methods for the batch fabrication of flat-panel micro-channel plate (MCP) photomultiplier tube (PMT) detectors (MCP-PMTs), without transporting either the window or the detector assembly inside a vacuum vessel are provided. The method allows for the synthesis of a reflection-mode photocathode on the entrance to the pores of a first MCP or the synthesis of a transmission-mode photocathode on the vacuum side of a photodetector entrance window.

  15. Imaging microchannel plate detectors for XUV sky survey experiments

    International Nuclear Information System (INIS)

    Barstow, M.A.; Fraser, G.W.; Milward, S.R.

    1986-01-01

    Attention is given to the development of microchannel plate detectors for the Wide Field Camera (WFC) XUV (50-300 A) sky survey experiment on Rosat. A novel feature of the detector design is that the microchannel plates and their resistive anode readout are curved to the same radius as the WFC telescope focal surface. It is shown that curving the channel plates is not detrimental to gain uniformity. The paper describes the design of a curved resistive anode readout element and contrasts the present measurements of spatial resolution, global and local uniformity and temperature coefficient of resistance with the poor performance recently ascribed to resistive anodes in the literature. 18 references

  16. Antiproton, positron, and electron imaging with a microchannel plate/phosphor detector

    CERN Document Server

    Andresen, G B; Bowe, P D; Bray, C; Butler, E; Cesar, C L; Chapman, S; Charlton, M; Fajans, J; Fujiwara, M C; Gill, D R; Hangst, J S; Hardy, W N; Hayano, R S; Hayden, M E; Humphries, A J; Hydomako, R; Jørgensen, L V; Kerrigan, S J; Kurchaninov, L; Lambo, R; Madsen, N; Nolan, P; Olchanski, K; Olin, A; Povilus, A; Pusa, P; Sarid, E; Seif El Nasr, S; Silveira, D M; Storey, J W; Thompson, R I; van der Werf, D P; Yamazaki, Y

    2009-01-01

    A microchannel plate (MCP)/phosphor screen assembly has been used to destructively measure the radial profile of cold, confined antiprotons, electrons, and positrons in the ALPHA experiment, with the goal of using these trapped particles for antihydrogen creation and confinement. The response of the MCP to low energy (10-200 eV, <1 eV spread) antiproton extractions is compared to that of electrons and positrons.

  17. A model of breakdown in parallel-plate detectors

    International Nuclear Information System (INIS)

    Fonte, P.

    1996-01-01

    Parallel-plate avalanche chambers (PPAC's) have many desirable properties, such as a fast, large area particle detector. However, the maximum gain is limited by a form of violent breakdown that limits the usefulness of this detector, despite its other evident qualities. The exact nature of this phenomenon is not yet sufficiently clear to sustain possible improvements. A previous experimental study is complemented in the present work by a quantitative model of the breakdown phenomenon in PPAC's, based on the streamer theory. The model reproduces well the peculiar behavior of the external current observed in PPAC's and resistive-plate chambers. Other breakdown properties measured in PPAC's are also well reproduced

  18. Micro-channel plate photon detector studies for the TORCH detector

    Energy Technology Data Exchange (ETDEWEB)

    Castillo García, L., E-mail: lucia.castillo.garcia@cern.ch [CERN, PH Department, CH-1211, Geneva 23 (Switzerland); Laboratory for High Energy Physics, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne (Switzerland); Brook, N.; Cowie, E.N.; Cussans, D. [H.H. Wills Physics Laboratory, University of Bristol, Bristol BS8 1TL (United Kingdom); Forty, R.; Frei, C. [CERN, PH Department, CH-1211, Geneva 23 (Switzerland); Gao, R. [Department of Physics, University of Oxford, Oxford OXI 3RH (United Kingdom); Gys, T. [CERN, PH Department, CH-1211, Geneva 23 (Switzerland); Harnew, N. [Department of Physics, University of Oxford, Oxford OXI 3RH (United Kingdom); Piedigrossi, D. [CERN, PH Department, CH-1211, Geneva 23 (Switzerland); Van Dijk, M. [H.H. Wills Physics Laboratory, University of Bristol, Bristol BS8 1TL (United Kingdom)

    2015-07-01

    The Time Of internally Reflected Cherenkov light (TORCH) detector is under development. Charged particle tracks passing through a 1 cm plate of quartz will generate the Cherenkov photons, and their arrival will be timed by an array of micro-channel plate photon detectors. As part of the TORCH R&D studies, commercial and custom-made micro-channel plate detectors are being characterized. The final photon detectors for this application are being produced in a three-phase program in collaboration with industry. Custom-made single-channel devices with extended lifetime have been manufactured and their performance is being systematically investigated in the laboratory. Optical studies for the preparation of beam and laboratory tests of a TORCH prototype are also underway.

  19. Rapid assessment of accidental exposures (RACE) with MCP-N (LiF:Mg,Cu,P) detectors

    International Nuclear Information System (INIS)

    Budzanowski, M.; Bilski, P.; Olko, P.; Saez-Vergara, J.C.; Gomes-Ros, J.M.

    1998-01-01

    The system is based on a new generation of ultra-sensitive thermoluminescent dosemeters and is able to monitor environmental radiation doses at a large number of locations within few days and to perform rapid (24 - 48 hours) in situ dose assessment in the event of any nuclear or radiation accident. Technical specifications of the instrumentation and procedures of the system are given. The linearity of the detector response for doses within the range of 1 μGy to 1 Gy is better than 2%. All the detectors investigated demonstrated a good stability in long-term exposure. The detectors are fully comparable with active detectors in short-term and daily routine dose rate measurements. (M.D.)

  20. A directional gamma-ray detector based on scintillator plates

    Energy Technology Data Exchange (ETDEWEB)

    Hanna, D., E-mail: hanna@physics.mcgill.ca; Sagnières, L.; Boyle, P.J.; MacLeod, A.M.L.

    2015-10-11

    A simple device for determining the azimuthal location of a source of gamma radiation, using ideas from astrophysical gamma-ray burst detection, is described. A compact and robust detector built from eight identical modules, each comprising a plate of CsI(Tl) scintillator coupled to a photomultiplier tube, can locate a point source of gamma rays with degree-scale precision by comparing the count rates in the different modules. Sensitivity to uniform environmental background is minimal.

  1. Microchannel plates as detectors and amplifiers of x-ray images

    International Nuclear Information System (INIS)

    Wiedwald, J.D.

    1992-08-01

    Two decades of development driven largely by military night vision applications has led to the availability of a wide selection of microchannel plates for use by the scientific community. Microchannel plates (MCPs) are electron multipliers which retain a high degree of spatial resolution making it possible to amplify electron images by factors of 1,000 or more. Plates having 40 mm diameter and intrinsic spatial resolution of 8 μm are readily available. By coating the front surface of a microchannel plate with an x-ray sensitive photocathode material, x-ray images can be detected and amplified. While the detective quantum efficiency is relatively low, the low noise of the MCP (including the ability to construct images by single photon detection) and its high dynamic range make it suitable for some x-ray microscopy applications. The principles of MCP operation and typical performance are discussed. Examples of related applications and commercial capabilities are also presented

  2. Application of imaging plate neutron detector to neutron radiography

    CERN Document Server

    Fujine, S; Kamata, M; Etoh, M

    1999-01-01

    As an imaging plate neutron detector (IP-ND) has been available for thermal neutron radiography (TNR) which has high resolution, high sensitivity and wide range, some basic characteristics of the IP-ND system were measured at the E-2 facility of the KUR. After basic performances of the IP were studied, images with high quality were obtained at a neutron fluence of 2 to 7x10 sup 8 n cm sup - sup 2. It was found that the IP-ND system with Gd sub 2 O sub 3 as a neutron converter material has a higher sensitivity to gamma-ray than that of a conventional film method. As a successful example, clear radiographs of the flat view for the fuel side plates with boron burnable poison were obtained. An application of the IP-ND system to neutron radiography (NR) is presented in this paper.

  3. A High-Speed, Event-Driven, Active Pixel Sensor Readout for Photon-Counting Microchannel Plate Detectors

    Science.gov (United States)

    Kimble, Randy A.; Pain, Bedabrata; Norton, Timothy J.; Haas, J. Patrick; Oegerle, William R. (Technical Monitor)

    2002-01-01

    Silicon array readouts for microchannel plate intensifiers offer several attractive features. In this class of detector, the electron cloud output of the MCP intensifier is converted to visible light by a phosphor; that light is then fiber-optically coupled to the silicon array. In photon-counting mode, the resulting light splashes on the silicon array are recognized and centroided to fractional pixel accuracy by off-chip electronics. This process can result in very high (MCP-limited) spatial resolution while operating at a modest MCP gain (desirable for dynamic range and long term stability). The principal limitation of intensified CCD systems of this type is their severely limited local dynamic range, as accurate photon counting is achieved only if there are not overlapping event splashes within the frame time of the device. This problem can be ameliorated somewhat by processing events only in pre-selected windows of interest of by using an addressable charge injection device (CID) for the readout array. We are currently pursuing the development of an intriguing alternative readout concept based on using an event-driven CMOS Active Pixel Sensor. APS technology permits the incorporation of discriminator circuitry within each pixel. When coupled with suitable CMOS logic outside the array area, the discriminator circuitry can be used to trigger the readout of small sub-array windows only when and where an event splash has been detected, completely eliminating the local dynamic range problem, while achieving a high global count rate capability and maintaining high spatial resolution. We elaborate on this concept and present our progress toward implementing an event-driven APS readout.

  4. New technique for radiation detection by instruments based on microchannel plates

    International Nuclear Information System (INIS)

    Ammosov, V.V.; Bolozdynya, A.I.; Kubantsev, M.A.; Lebedenko, V.N.; Suvorov, A.L.

    1986-01-01

    Coordinate information can be obtained directly from microchanel plates (MCP) as storage matrix in MCP based radiation detectors, which is proved using as an example the registering of pulsed laser ultraviolet radiation. For read-out and representation of the information the TV channel was used: the vidicon electron-optical system - TV transmission camera - TV monitor

  5. Characterization of nanoDot optically stimulated luminescence detectors and high-sensitivity MCP-N thermoluminescent detectors in the 40-300 kVp energy range.

    Science.gov (United States)

    Poirier, Yannick; Kuznetsova, Svetlana; Villarreal-Barajas, Jose Eduardo

    2018-01-01

    To investigate empirically the energy dependence of the detector response of two in vivo luminescence detectors, LiF:Mg,Cu,P (MCP-N) high-sensitivity TLDs and Al 2 O 3 :C OSLDs, in the 40-300-kVp energy range in the context of in vivo surface dose measurement. As these detectors become more prevalent in clinical and preclinical in vivo measurements, knowledge of the variation in the empirical dependence of the measured response of these detectors across a wide spectrum of beam qualities is important. We characterized a large range of beam qualities of three different kilovoltage x-ray units: an Xstrahl 300 Orthovoltage unit, a Precision x-Ray X-RAD 320ix biological irradiator, and a Varian On-Board Imaging x-ray unit. The dose to water was measured in air according to the AAPM's Task Group 61 protocol. The OSLDs and TLDs were irradiated under reference conditions on the surface of a water phantom to provide full backscatter conditions. To assess the change in sensitivity in the long term, we separated the in vivo dosimeters of each type into an experimental and a reference group. The experimental dosimeters were irradiated using the kilovoltage x-ray units at each beam quality used in this investigation, while the reference group received a constant 10 cGy irradiation at 6 MV from a Varian clinical linear accelerator. The individual calibration of each detector was verified in cycles where both groups received a 10 cGy irradiation at 6 MV. The nanoDot OSLDs were highly reproducible, with ±1.5% variation in response following >40 measurement cycles. The TLDs lost ~20% of their signal sensitivity over the course of the study. The relative light output per unit dose to water of the MCP-N TLDs did not vary with beam quality for beam qualities with effective energies <50 keV (~150 kVp/6 mm Al). At higher energies, they showed a reduced (~75-85%) light output per unit dose relative to 6 MV x rays. The nanoDot OSLDs exhibited a very strong (120

  6. The resistive plate WELL detector as a single stage thick gaseous multiplier detector

    Energy Technology Data Exchange (ETDEWEB)

    Bressler, Shikma; Breskin, Amos; Moleri, Luca; Kumar, Ashwini; Pitt, Michael [Department of Particle Physics and Astrophysics, Weizmann Institute of Science (WIS) (Israel); Kudella, Simon [Institut fuer Experimentelle Kernphysik (IEKP), KIT (Germany)

    2015-07-01

    Gaseous Electron Multiplier (GEM) detector use high electric fields inside the h ole of a foil to achieve a high charge multiplication. As a thicker version of G EMs based on printed circuit board (PCB) structures, Thick Gaseous Electron Multiplier (THGEM) detectors combine the high gain of a GEM foil with the robustness, stability and low production costs of a PCB and allow a large quantity of applications that require the coverage of a large area at low cost and moderate spatial resolution. One application the Weizmann Institute of Science (WIS) develops as a member of the RD51 framework is the Resistive Plate WELL (RPWELL) detector. This single stage detector allows a very stable, discharge free operation at high gain (10{sup 5}). The single stage operation allows a low total height and make s the RPWELL a candidate for the Digital Hadronic Calorimeter (DHCAL) of the International Large Detector (ILD) at the International Linear Collider (ILC). The talk gives an insight into the way the RPWELL works and shows results from the last test beam.

  7. Radioisotope decontamination of X-ray detector. Photostimulable phosphor plate

    International Nuclear Information System (INIS)

    Onuma, Yoji; Hayashi, Michiko; Hayashi, Hiroaki; Nishihara, Sadamitsu

    2012-01-01

    We tried to remove contamination of radioisotope (RI) for an X-ray detector (photostimulable phosphor plate; IP) and verified that our procedure suggested by Nishihara et al. was effective for decontamination. The procedure was as follows. First, the IP was kept for approximately twelve hours, and then it was processed [image (A)] as well as a clinical processing mode. Second, using a wet-type chemical wiper, we scavenged the IP to remove the adhered RI on its surface. Then, once again, the IP was kept for approximately fifteen hours and processed [image (B)] in order to check an effect of decontamination. Finally, the two images of (A) and (B) were analyzed using ImageJ, which can be downloaded as a free software, and a percentage of removal was calculated. The procedure was applied to two IPs using the Fuji computed tomography (FCR) 5501 plus. In the present case, the percentage of removal was approximately 96%. The removed radioisotopes in the chemical wipers were analyzed by Ge detector. Then, 134 Cs and 137 Cs were found with activities of 2.9 4.3 Bq and 3.5 5.2 Bq, respectively. For three months after that, we cannot see black spots on the IPs owing to the contamination of the RI and there are no defects caused by decontamination using a wet-type chemical wiper. (author)

  8. Application of PSpice circuit simulator in development of resistive plate chamber detector

    International Nuclear Information System (INIS)

    Wang Yaping; Cai Xu

    2008-01-01

    An electrical model was presented for resistive plate chamber (RPC) detector. The readout signals of RPC detector were studied with PSpice simulation based on the model. The simulation results show a good agreement with real data and authoritative data. Physical performance of RPC detector can be predicted by the PSpice simulation, so this is an efficient means to optimize RPC detector's research and development. (authors)

  9. High-Rate Glass Resistive Plate Chambers For LHC Muon Detectors Upgrade

    CERN Document Server

    Laktineh, I; Cauwenbergh, S; Combret, C; Crotty, I; Haddad, Y; Grenier, G; Guida, R; Kieffer, R; Lumb, N; Mirabito, L; Schirra, F; Seguin, N; Tytgat, M; Van der Donckt, M; Wang, Y; Zaganidis, N

    2012-01-01

    The limitation of the detection rate of standard bakelite resistive plate chambers (RPC) used as muon detector in LHC experiments is behind the absence of such detectors in the high TJ regions in both CMS and ATLAS detectors. RPCs made with low resistivity glass plates (10ID O.cm) could be an adequate solution to equip the high TJ regions extending thus both the trigger efficiency and the physics performance. Different beam tests with single and multi-gap configurations using the new glass have shown that such detectors can operate at few thousands Hzlcm2 with high efficiency( > 90%).

  10. Preliminary studies of microchannel plate photomultiplier tube neutron detectors for flight test applications

    International Nuclear Information System (INIS)

    Dolan, K.W.

    1978-10-01

    Electrical, mechanical, thermal, and neutron response data indicate that microchannel plate photomultiplier tubes are viable candidates as miniature, ruggedized neutron detectors for flight test applications in future weapon systems

  11. A position sensitive parallel plate avalanche fission detector for use in particle induced fission coincidence measurements

    NARCIS (Netherlands)

    Plicht, J. van der

    1980-01-01

    A parallel plate avalanche detector developed for the detection of fission fragments in particle induced fission reactions is described. The active area is 6 × 10 cm2; it is position sensitive in one dimension with a resolution of 2.5 mm. The detector can withstand a count rate of 25000 fission

  12. A tilted fiber-optic plate coupled CCD detector for high resolution neutron imaging

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jongyul; Cho, Gyuseong [Korea Advanced Institute of Science and Technology, Daejeon (Korea, Republic of); Kim, Jongyul; Hwy, Limchang; Kim, Taejoo; Lee, Kyehong [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Lee, Seungwook [Pusan National Univ., Pusan (Korea, Republic of)

    2013-05-15

    One of these efforts is that a tilted scintillator geometry and lens coupled CCD detector for neutron imaging system were used to improve spatial resolution in one dimension. The increased spatial resolution in one dimension was applied to fuel cell study. However, a lens coupled CCD detector has lower sensitivity than a fiber-optic plate coupled CCD detector due to light loss. In this research, a tilted detector using fiber-optic plate coupled CCD detector was developed to improve resolution and sensitivity. In addition, a tilted detector can prevent an image sensor from direct radiation damage. Neutron imaging has been used for fuel cell study, lithium ion battery study, and many scientific applications. High quality neutron imaging is demanded for more detailed studies of applications, and spatial resolution should be considered to get high quality neutron imaging. Therefore, there were many efforts to improve spatial resolution.

  13. A zerotime detector for nuclear fragments using channel electron multiplier plates

    International Nuclear Information System (INIS)

    Sundqvist, B.

    1975-01-01

    The literature on zerotime detectors which use the emission of secondary electrons from a thin foil is reviewed. The construction of a zerotime detector using multiplication of the secondary electrons with two Mullard channel electron multiplier plates (CEMP) in tandem is described. Results of tests of such a detector with α particles from a natural α source are given. Total time resolutions of about 200 ps (FWHM) with a Si(Sb) detector as the stop detector has been achieved. The contribution from the zerotime detector is estimated to be less than 150 ps (FWHM). The application of this detector technique to the construction of a heavy-ion spectrometer and a 8 Be detector is described. (Auth)

  14. Neutron diffractometer for bio-crystallography (BIX) with an imaging plate neutron detector

    Energy Technology Data Exchange (ETDEWEB)

    Niimura, Nobuo [Japan Atomic Energy Research Inst., Ibaraki-ken (Japan)

    1994-12-31

    We have constructed a dedicated diffractometer for neutron crystallography in biology (BIX) on the JRR-3M reactor at JAERI (Japan Atomic Energy Research Institute). The diffraction intensity from a protein crystal is weaker than that from most inorganic materials. In order to overcome the intensity problem, an elastically bent silicon monochromator and a large area detector system were specially designed. A preliminary result of diffraction experiment using BIX has been reported. An imaging plate neutron detector has been developed and a feasibility experiment was carried out on BIX. Results are reported. An imaging plate neutron detector has been developed and a feasibility test was carried out using BIX.

  15. Development of hybrid track detector using CR39 and photographic plate

    International Nuclear Information System (INIS)

    Kuge, Kenichi; Endo, Yusuke; Hayashi, Kentaro; Hasegawa, Akira; Kumagai, Hiroshi

    2004-01-01

    Hybrid track detector using CR39 and color photography was prepared by coating multi-layered color photographic emulsions on one side of CR39. Etch pits and color tracks were observed at the same time. Photographic plate with different sensitivity emulsions and couplers were exposed to light, α-, β- and γ-rays. We observed sensitivity difference to the radiation by color changes on one plate. (authors)

  16. [Controlled evaluation of a high-resolution three-dimensional magnetic detector system (3D-MAGMA) as a proof of concept - examination of healthy volunteers before and after application of Metoclopramide (MCP)].

    Science.gov (United States)

    Jacob, V Y P; Stallmach, A; Felber, J

    2016-06-01

    Changes in gastric and small bowel motility are a common clinical problem. Currently diagnostic options are limited because each method harbors certain disadvantages. It has been shown that the high-resolution three-dimensional magnetic detector system 3D-MAGMA is capable of reliably measuring gastric and small intestine motor activity. This system allows precise localization of a small magnetic marker and determination of its three-dimensional orientation inside a human body. The aim of the current study was to determine if 3D-MAGMA is reliably able to detect changes in gastric and small bowel motility under controlled conditions. MCP was used as a well known prokinetic agent to shorten the gastric and small bowel passage. 8 healthy volunteers (fasting) underwent motility testing of the stomach and small bowel by 3D-MAGMA with and without administration of MCP (10 mg orally). Among other data the time the capsule needed to pass through the stomach and the duodenum and the time the capsule needed to pass through the first 50 cm of the jejunum were recorded. The retention time of the capsule in the stomach under physiological conditions was 49.1 minutes (median; min. 18 min; max. 88.8 min). The median time the capsule needed to pass through the duodenum was 13.8 minutes (median; min. 1.7 min; max. 24.8 min). The time the capsule needed to pass through the first 50 cm of the jejunum under physiological conditions was 33.0 minutes (median; min. 20.2 min; max. 67.2 min). The retention time of the capsule in the stomach decreased significantly after administration of MCP to 20.9 minutes (median; min. 1.7 min; max. 62.8 min; p = 0.008). The time the capsule needed to pass through the duodenum was also reduced to 7.1 minutes (median; min. 3.1 min; max. 18.3 min; p = 0.055). The time the capsule needed to pass through the first 50 cm of the jejunum was also reduced to 21.7 minutes (median; min. 10.7 min; max. 31.2 min; p = 0.069). 3D-MAGMA is able

  17. Two micron pore size MCP-based image intensifiers

    Science.gov (United States)

    Glesener, John; Estrera, Joseph

    2010-02-01

    Image intensifiers (I2) have many advantages as detectors. They offer single photon sensitivity in an imaging format, they're light in weight and analog I2 systems can operate for hours on a single AA battery. Their light output is such as to exploit the peak in color sensitivity of the human eye. Until recent developments in CMOS sensors, they also were one of the highest resolution sensors available. The closest all solid state solution, the Texas Instruments Impactron chip, comes in a 1 megapixel format. Depending on the level of integration, an Impactron based system can consume 20 to 40 watts in a system configuration. In further investing in I2 technology, L-3 EOS determined that increasing I2 resolution merited a high priority. Increased I2 resolution offers the system user two desirable options: 1) increased detection and identification ranges while maintaining field-of-view (FOV) or 2) increasing FOV while maintaining the original system resolution. One of the areas where an investment in resolution is being made is in the microchannel plate (MCP). Incorporation of a 2 micron MCP into an image tube has the potential of increasing the system resolution of currently fielded systems. Both inverting and non-inverting configurations are being evaluated. Inverting tubes are being characterized in night vision goggle (NVG) and sights. The non-inverting 2 micron tube is being characterized for high resolution I2CMOS camera applications. Preliminary measurements show an increase in the MTF over a standard 5 micron pore size, 6 micron pitch plate. Current results will be presented.

  18. In-beam evaluation of a medium-size Resistive-Plate WELL gaseous particle detector

    CERN Document Server

    Moleri, L.

    2016-09-27

    In-beam evaluation of a fully-equipped medium-size 30$\\times$30 cm$^2$ Resistive Plate WELL (RPWELL) detector is presented. It consists here of a single element gas-avalanche multiplier with Semitron ESD225 resistive plate, 1 cm$^2$ readout pads and APV25/SRS electronics. Similarly to previous results with small detector prototypes, stable operation at high detection efficiency (>98%) and low average pad multiplicity (~1.2) were recorded with 150 GeV muon and high-rate pion beams, in Ne/(5%CH$_4$), Ar/(5%CH$_4$) and Ar/(7%CO$_2$). This is an important step towards the realization of robust detectors suitable for applications requiring large-area coverage; among them Digital Hadron Calorimetry.

  19. Lifetime of MCP-PMTs and other performance features

    Science.gov (United States)

    Lehmann, A.; Böhm, M.; Eyrich, W.; Miehling, D.; Pfaffinger, M.; Stelter, S.; Uhlig, F.; Ali, A.; Belias, A.; Dzhygadlo, R.; Gerhardt, A.; Götzen, K.; Kalicy, G.; Krebs, M.; Lehmann, D.; Nerling, F.; Patsyuk, M.; Peters, K.; Schepers, G.; Schmitt, L.; Schwarz, C.; Schwiening, J.; Traxler, M.; Düren, M.; Etzelmüller, E.; Föhl, K.; Hayrapetyan, A.; Kreutzfeld, K.; Merle, O.; Rieke, J.; Schmidt, M.; Wasem, T.; Achenbach, P.; Cardinali, M.; Hoek, M.; Lauth, W.; Schlimme, S.; Sfienti, C.; Thiel, M.

    2018-02-01

    The bar PANDA experiment at FAIR will use DIRC detectors for the separation of hadrons. The compactness of the bar PANDA detector requires the image planes of these detectors to be placed inside the magnetic field of the solenoid. Due to this and other boundary conditions MCP-PMTs were identified as the only suitable photon sensors. Until recently the major obstacle for an application of MCP-PMTs in high rate experiments like bar PANDA were serious aging problems which led to damage at the photo-cathode and a fast declining quantum efficiency as the integrated anode charge (IAC) increased. With new countermeasures against the aging, in particular due to the application of an atomic layer deposition (ALD) technique to coat the MCP pores, the lifetime of MCP-PMTs has meanwhile increased by a factor >50 which is fully sufficient for bar PANDA. The recent results of our long-term lifetime measurements are discussed. New 2-inch MCP-PMT prototypes from Hamamatsu show an encouraging behavior. However, the currently best performing MCP-PMT is a 2-inch PHOTONIS tube with two ALD-layers which reaches an IAC of >16 C/cm2 without any visible sign of aging. In the second part of these proceedings a new data acquisition system of the PADIWA/TRB type is presented which allows a quasi-parallel measurement of many MCP-PMT performance parameters. Especially unwanted effects like dark-count rate, crosstalk, ion after-pulsing, and recoil electrons can be studied in more detail than ever before. Exemplary results for these parameters are shown. The discussed DAQ system will be used for the comprehensive data quality checks of the MCP-PMTs being built into the DIRCs.

  20. Development of a dual MCP framing camera for high energy x-rays

    Energy Technology Data Exchange (ETDEWEB)

    Izumi, N., E-mail: izumi2@llnl.gov; Hall, G. N.; Carpenter, A. C.; Allen, F. V.; Cruz, J. G.; Felker, B.; Hargrove, D.; Holder, J.; Lumbard, A.; Montesanti, R.; Palmer, N. E.; Piston, K.; Stone, G.; Thao, M.; Vern, R.; Zacharias, R.; Landen, O. L.; Tommasini, R.; Bradley, D. K.; Bell, P. M. [Lawrence Livermore National Laboratory, Livermore, California 94550 (United States); and others

    2014-11-15

    Recently developed diagnostic techniques at LLNL require recording backlit images of extremely dense imploded plasmas using hard x-rays, and demand the detector to be sensitive to photons with energies higher than 50 keV [R. Tommasini et al., Phys. Phys. Plasmas 18, 056309 (2011); G. N. Hall et al., “AXIS: An instrument for imaging Compton radiographs using ARC on the NIF,” Rev. Sci. Instrum. (these proceedings)]. To increase the sensitivity in the high energy region, we propose to use a combination of two MCPs. The first MCP is operated in a low gain regime and works as a thick photocathode, and the second MCP works as a high gain electron multiplier. We tested the concept of this dual MCP configuration and succeeded in obtaining a detective quantum efficiency of 4.5% for 59 keV x-rays, 3 times larger than with a single plate of the thickness typically used in NIF framing cameras.

  1. Systematic studies of micro-channel plate PMTs

    International Nuclear Information System (INIS)

    Lehmann, A.; Britting, A.; Cowie, E.; Dodokhof, V.Kh.; Dueren, M.; Dutta, D.; Eyrich, W.; Foehl, K.; Glazier, D.I.; Hayrapetyan, A.; Hoek, M.; Hohler, R.; Kaiser, R.; Keri, T.; Koch, P.; Kroeck, B.; Lehmann, D.; Marton, J.; Merle, O.; Montgomery, R.

    2011-01-01

    DIRC Cherenkov detectors will be the main devices for π/K separation at the PANDA experiment at FAIR. Due to their advantageous properties in terms of time resolution and especially inside magnetic fields micro-channel plate photo multipliers (MCP-PMTs) are very attractive sensor candidates. In this paper we present the investigation of several types of multi-anode MCP-PMTs. The darkcount rate, the behavior inside a magnetic field of up to 2 T, the time resolution, the gain homogeneity and crosstalk of multi-pixel MCP-PMTs were found to be well suitable for the PANDA requirements. Even the rate capability of the latest models from Burle-Photonis and Hamamatsu is satisfactory. Although a big step forward was accomplished with these recently available MCP-PMTs, the lifetime is still not sufficient for the photon densities expected for the PANDA DIRCs.

  2. Imaging plate, a new type of x-ray area detector

    International Nuclear Information System (INIS)

    Kamiya, Nobuo; Amemiya, Yoshiyuki; Miyahara, Junji.

    1986-01-01

    In respective fields of X-ray crystallography, for the purpose of the efficient collection of reciprocal space information, two-dimensional X-ray detectors such as multiwire proportional chambers and X-ray television sets have been used together with conventional X-ray films. X-ray films are characterized by uniform sensitivity and high positional resolution over a wide area, but the sensitivity is low, and the range of action and the linearity of the sensitivity is problematic. They require the development process, accordingly lack promptitude. The MWPCs and X-ray television sets are superior in the sensitivity, its linearity, the range of action and promptitude, but interior in the uniformity and resolution to the films. Imaging plate is a new X-ray area detector developed by Fuji Photo Film Co., Ltd., for digital X-ray medical image diagnosis. This detector is superior in all the above mentioned performances, and it seems very useful also for X-ray crystallography. In this paper, the system composed of an imaging plate and its reader is described, and the basic performance as an X-ray area detector and the results of having recorded the diffraction images of protein crystals as the example of applying it to X-ray crystallography are reported. The imaging plate is that the crystalline fluorescent powder of BaFBr doped with Eu 2+ ions is applied on plastic films. (Kako, I.)

  3. Evaluation of In-Vacuum Imaging Plate Detector for X-Ray Diffraction Microscopy

    International Nuclear Information System (INIS)

    Nishino, Yoshinori; Takahashi, Yukio; Yamamoto, Masaki; Ishikawa, Tetsuya

    2007-01-01

    We performed evaluation tests of a newly developed in-vacuum imaging plate (IP) detector for x-ray diffraction microscopy. IP detectors have advantages over direct x-ray detection charge-coupled device (CCD) detectors, which have been commonly used in x-ray diffraction microscopy experiments, in the capabilities for a high photon count and for a wide area. The detector system contains two IPs to make measurement efficient by recording data with the one while reading or erasing the other. We compared speckled diffraction patterns of single particles taken with the IP and a direct x-ray detection CCD. The IP was inferior to the CCD in spatial resolution and in signal-to-noise ratio at a low photon count

  4. Fast front-end L0 trigger electronics for ALICE FMD-MCP tests and performance

    CERN Document Server

    Efimov, L G; Kasatkan, V; Klempt, W; Kuts, V; Lenti, V; Platanov, V; Rudge, A; Stolyarov, O I; Tsimbal, F A; Valiev, F F; Villalobos Baillie, O; Vinogradov, L I; Zhigunov, O

    1997-01-01

    We present design details and new measurements of the performance of fast electronics for the Forward Multiplicity Detector for ALICE. These detectors based on sector type Microchannel Plates (MCP) forming several disks gave the very first trigger decision in the experiment (L0). Fast passive summators integrated with the detectors are used for linear summation of up to eight isochronous signal channels from MCP pads belonging to one sector. Two types of microelectronics design thin film summators were produced. We present test results for these summators, working in the frequency range up to 1 Ghz. New low noise preamplifiers have been built to work with these summators. The new design shows a good performance with the usable frequency range extended up to 1 Ghz. An upgrade of the functional scheme for the L0 ALICE pre-trigger design is also presented.Abstract:List of figures Figure 1: ALICE L0 Trigger Front-End Electronics Functional Scheme. Figure 2: UHF design for a fast passive summator based on direct...

  5. The sensitivity calibration of the ultra-fast quench plastic scintillation detector for D-T neutrons

    International Nuclear Information System (INIS)

    Tang Changhuan; Yan Meiqiong; Xie Chaomei

    1998-01-01

    The authors introduce some characteristics of ultra-fast quench plastic scintillation detectors. When the detectors are composed of different scintillators, light guides and microchannel plate photomultiplier tube (MCP-PMT), their sensitivities to D-T neutrons are calibrated by a pulse neutron tube with a neutron pulse width about 10 ns

  6. A Neutron Sensitive Microchannel Plate Detector with Cross Delay Line Readout

    International Nuclear Information System (INIS)

    Berry, Kevin D.; Bilheux, Hassina Z.; Crow, Lowell; Diawara, Yacouba; Feller, W. Bruce; Iverson, Erik B.; Martin, Adrian; Robertson, J. Lee

    2012-01-01

    Microchannel plates containing neutron absorbing elements such as boron and gadolinium in the bulk glass are used as the sensing element in high spatial resolution, high rate neutron imaging systems. In this paper we describe one such device, using both 10 B and natural Gd, which employs cross delay line signal readout, with time-of-flight capability. This detector has a measured spatial resolution under 40 m FWHM, thermal neutron efficiency of 19%, and has recorded rates in excess of 500 kHz. A physical and functional description is presented, followed by a discussion of measurements of detector performance and a brief survey of some practical applications.

  7. A new method to measure and increase the detection efficiency of a microchannel plate for 100 keV electrons

    International Nuclear Information System (INIS)

    Tornow, R.P.

    1990-01-01

    A new method is described which permits measurement of efficiency of a microchannel plate (MCP) simply by tracing the output current pulse in the saturated mode. The dependence of the detection efficiency on the gain of the input stages of a detector is calculated and the result is applied to a MCP. Furthermore, an enhancement of the detection efficiency of a MCP is presented for 100 keV electrons up to more than 90% by means of the field-enhanced secondary electron emission. (author)

  8. Detectors for LIDAR type Thomson scattering diagnostics

    International Nuclear Information System (INIS)

    Hirsch, K.

    1991-04-01

    A report on the capability of the microchannel plate photomultiplier type (ITT F4128) presently used at the JET LIDAR Thomson Scattering System is given. Detailed investigation on time response, low noise amplification, shutter ratio, gating behaviour, linear mode of operation and saturation pulse recovery carried out during the design phase for LIDAR are presented. New investigation with respect to dc- and gated operation showed no measurable changes in sensitivity of this MCP photomultiplier. Comparing this type of detector with other MCP photomultipliers and with streak cameras some detection schemes for future LIDAR type diagnostic are proposed. (orig.)

  9. Simulation of the electron collection efficiency of a PMT based on the MCP coated with high secondary yield material

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Lin, E-mail: chenlin@opt.cn [State Key Laboratory of Transient Optics and Photonics, Xi' an Institute of Optics and Precision Mechanics (XIOPM), Chinese Academy of Sciences (CAS), Xi' an 710119 (China); Graduate School of Chinese Academy of Sciences (CAS), Beijing 100049 (China); Xi' an Jiaotong University, Xi' an 710049 (China); Collaborative Innovation Center of Extreme Optics, Shanxi University, Taiyuan 030006 (China); Tian, Jinshou [State Key Laboratory of Transient Optics and Photonics, Xi' an Institute of Optics and Precision Mechanics (XIOPM), Chinese Academy of Sciences (CAS), Xi' an 710119 (China); Collaborative Innovation Center of Extreme Optics, Shanxi University, Taiyuan 030006 (China); Zhao, Tianchi [Institute of High Energy Physics (IHEP) of CAS, Beijing 100049 (China); Liu, Chunliang [Xi' an Jiaotong University, Xi' an 710049 (China); Liu, Hulin; Wei, Yonglin; Sai, Xiaofeng [State Key Laboratory of Transient Optics and Photonics, Xi' an Institute of Optics and Precision Mechanics (XIOPM), Chinese Academy of Sciences (CAS), Xi' an 710119 (China); Chen, Ping [State Key Laboratory of Transient Optics and Photonics, Xi' an Institute of Optics and Precision Mechanics (XIOPM), Chinese Academy of Sciences (CAS), Xi' an 710119 (China); Graduate School of Chinese Academy of Sciences (CAS), Beijing 100049 (China); Wang, Xing; Lu, Yu [State Key Laboratory of Transient Optics and Photonics, Xi' an Institute of Optics and Precision Mechanics (XIOPM), Chinese Academy of Sciences (CAS), Xi' an 710119 (China); Hui, Dandan [State Key Laboratory of Transient Optics and Photonics, Xi' an Institute of Optics and Precision Mechanics (XIOPM), Chinese Academy of Sciences (CAS), Xi' an 710119 (China); Graduate School of Chinese Academy of Sciences (CAS), Beijing 100049 (China)

    2016-11-01

    Owning to the serious loss of photoelectrons striking at the input electrode of traditional microchannel plate (MCP), photoelectron collection efficiency (CE) of photomultiplier tubes based on MCP (MCP-PMTs) fluctuates around the MCP open area fraction and cannot make a breakthrough. Depositing a thin film of high secondary electron yield material on the MCP is proposed as an effective approach to improve the CE. The available simulation and experimental data to validate it, however, is sparse. In our work, a three-dimensional small area MCP model is developed in CST Studio Suite to evaluate the collection efficiencies of PMTs based on the traditional MCP and the coated one, respectively. Results predict that CE of the PMT based on the coated MCP has a significant increase and a better uniformity, which is expected to reach 100%.

  10. Gain stabilized microchannel plates and a treatment method for microchannel plates

    International Nuclear Information System (INIS)

    1979-01-01

    Microchannel plates having increased gain and significantly improved aging characteristics are provided by forming a thin film of a cesium compound on the channel walls. In an exemplary embodiment, a suface film of cesium hydroxide is applied to the interior wall surfaces of an MCP by saturating the plate with a solution of the compound, then allowing the solvent to evaporate. The cesium hydroxide residue on the walls subsequently is converted to cesium oxide by a high temperature bake. Microchannel plates are used in image amplifiers, radiation detectors and such like equipment. (Auth.)

  11. HV Test of the CTS Edgeless Silicon Detector in Vacuum and Close to a Grounded Plate

    CERN Document Server

    Eremin, Vladimir; Ruggiero, Gennaro

    2007-01-01

    The TOTEM Roman Pot Silicon sensors will be operated in vacuum to minimise the mechanical stress of the thin metal window which separates the detector package from the ultra high vacuum of the beam. To approach the beam axis as close as possible the detectors will be mounted with their edge at a distance of the order 100 - 200 um from the thin metal window. As the detectors will be run in overdepletion mode to allow the full charge collection within the shaping time of the readout electronics, there will be a potential drop of more than 100 V across their edge. Moreover this potential drop might need to be further increased with the accumulated radiation dose. The main goals of the tests described in this note are: - Characterisation of the voltage-current characteristics when the detector edge is in the direct vicinity of a grounded metal plate which simulates the above mentioned vacuum window; - Demonstration of the detector operation in vacuum at different pressures.

  12. Performance, operation and detector studies with the ATLAS Resistive Plate Chambers

    International Nuclear Information System (INIS)

    Aielli, G; Bindi, M; Polini, A

    2013-01-01

    Resistive Plate Chambers provide the barrel region of the ATLAS detector with an independent muon trigger and a two-coordinate measurement. The chambers, arranged in three concentric double layers, are operated in a strong magnetic toroidal field and cover a surface area of about 4000 m 2 . During 2011 the LHC has provided proton-proton collisions at 7 TeV in the center-of-mass frame with a steady increase in instantaneous luminosity, summing up to about 5 fb −1 . The operational experience for this running period is presented along with studies of the detector performance as a function of luminosity, environmental conditions and working point settings. Non-event based information including in particular the large number of gas gap currents, individually monitored with nA accuracy, have been used to study the detector behavior with growing luminosity and beam currents. These data are shown to provide, when calibrated, an independent luminosity measurement and a crucial handle for understanding the ATLAS backgrounds well beyond the scope of muon triggering and detection. The measurements presented here allow to plan a strategy for the data taking in the next years and make some predictions about the detector performance at higher luminosities. They also improve the knowledge on RPC detector physics.

  13. 2Kx2K resolution element photon counting MCP sensor with >200 kHz event rate capability

    CERN Document Server

    Vallerga, J V

    2000-01-01

    Siegmund Scientific undertook a NASA Small Business Innovative Research (SBIR) contract to develop a versatile, high-performance photon (or particle) counting detector combining recent technical advances in all aspects of Microchannel Plate (MCP) detector development in a low cost, commercially viable package that can support a variety of applications. The detector concept consists of a set of MCPs whose output electron pulses are read out with a crossed delay line (XDL) anode and associated high-speed event encoding electronics. The delay line anode allows high-resolution photon event centroiding at very high event rates and can be scaled to large formats (>40 mm) while maintaining good linearity and high temporal stability. The optimal sensitivity wavelength range is determined by the choice of opaque photocathodes. Specific achievements included: spatial resolution of 200 000 events s sup - sup 1; local rates of >100 events s sup - sup 1 per resolution element; event timing of <1 ns; and low background ...

  14. Study of imaging plate detector sensitivity to 5-18 MeV electrons

    Energy Technology Data Exchange (ETDEWEB)

    Boutoux, G., E-mail: boutoux@celia.u-bordeaux1.fr; Rabhi, N.; Batani, D.; Ducret, J.-E. [Univ. de Bordeaux, CNRS, CEA, CELIA (Centre Lasers Intenses et Applications), UMR 5107, F-33405 Talence (France); Binet, A.; Nègre, J.-P.; Reverdin, C.; Thfoin, I. [CEA DAM DIF, F-91297 Arpajon (France); Jakubowska, K. [Institute of Plasma Physics and Laser Microfusion, Hery Street 23, 01-497 Warsaw (Poland)

    2015-11-15

    Imaging plates (IPs) are commonly used as passive detectors in laser-plasma experiments. We calibrated at the ELSA electron beam facility (CEA DIF) the five different available types of IPs (namely, MS-SR-TR-MP-ND) to electrons from 5 to 18 MeV. In the context of diagnostic development for the PETawatt Aquitaine Laser (PETAL), we investigated the use of stacks of IP in order to increase the detection efficiency and get detection response independent from the neighboring materials such as X-ray shielding and detector supports. We also measured fading functions in the time range from a few minutes up to a few days. Finally, our results are systematically compared to GEANT4 simulations in order to provide a complete study of the IP response to electrons over the energy range relevant for PETAL experiments.

  15. Water resistant rhodium plated reflectors for use in the DIRC BaBar Cherenkov detector

    CERN Document Server

    Benkebil, M; Plaszczynski, S; Schune, M H; Wormser, G

    2000-01-01

    Early simulation studies showed that reflectors mounted on the photomultipliers would be useful for the DIRC BaBar Cherenkov detector, showing a gain between 20% and 30% in the number of Cherenkov photons. The proof of principle for these reflectors has been obtained during the beam test of a large-scale prototype of the DIRC detector. An extensive R and D has been conducted in order to test different metallization procedures. Indeed, the challenge was to find a metallization technique which can resist the pure de-ionized water (>15 M OMEGA) up to 10 yr. The chosen technology was rhodium plated reflectors. During the first BaBar cosmic run, the measured performance confirmed the results of the simulation, the prototype-II and the R and D.

  16. Determination of alpha particle detection efficiency of an imaging plate (IP) detector

    International Nuclear Information System (INIS)

    Rahman, N.M; Iida, Takao; Yamazawa, Hiromi; Moriizumi, Jun

    2006-01-01

    In order to determine the detection efficiency of the imaging plate (IP) detector, the true radioactivity of the alpha particles, which sampled in the collection media, should be known. The true radioactivity could be accurately predicted with the help of the reference alpha spectrometer measurement. The detection efficiency calculated for the IP was estimated with the theoretical curve and the experimental data. It is assumed that the air sample contained the decay products of both 222 Rn and 220 Rn series, the most significant sources of alpha particles. The present study estimated the detection efficiency of the IP as 39.3% with an uncertainty of 2.9 that is well enough to confirm the future use of the IP as a radiation detector. Experimental materials and methods are described. (S.Y.)

  17. Aging study for resistive plate chambers of the CMS muon trigger detector

    CERN Document Server

    Abbrescia, M; Iaselli, G; Loddo, F; Maggi, M; Marangelli, B; Natali, S; Nuzzo, S; Pugliese, G; Ranieri, A; Romano, F; Altieri, S; Belli, G; Bruno, G; Guida, R; Ratti, S P; Riccardi, C; Torre, P; Vitulo, P

    2003-01-01

    A long-term aging test of a Resistive Plate Chamber (RPC) was carried out with an intense gamma **1**3**7Cs source. The detector was operated in avalanche mode and had the bakelite surface treated with linseed oil. After the irradiation the estimated dose, charge and fluence were approximately equal to the expected values after 10 years of operation in the CMS barrel region. During and after the irradiation, the RPC performance was monitored with cosmic muons and showed no relevant aging effects. Moreover, no variation of the bakelite resistance was observed.

  18. Aging study for resistive plate chambers of the CMS muon trigger detector

    Energy Technology Data Exchange (ETDEWEB)

    Abbrescia, M.; Colaleo, A.; Iaselli, G.; Loddo, F.; Maggi, M.; Marangelli, B.; Natali, S.; Nuzzo, S.; Pugliese, G. E-mail: gabriella.pugliese@ba.infn.it; Ranieri, A.; Romano, F.; Altieri, S.; Belli, G.; Bruno, G.; Guida, R.; Ratti, S.P.; Riccardi, C.; Torre, P.; Vitulo, P

    2003-12-01

    A long-term aging test of a Resistive Plate Chamber (RPC) was carried out with an intense gamma {sup 137}Cs source. The detector was operated in avalanche mode and had the bakelite surface treated with linseed oil. After the irradiation the estimated dose, charge and fluence were approximately equal to the expected values after 10 years of operation in the CMS barrel region. During and after the irradiation, the RPC performance was monitored with cosmic muons and showed no relevant aging effects. Moreover, no variation of the bakelite resistance was observed.

  19. Development and Evaluation of the Muon Trigger Detector Using a Resistive Plate Chamber

    International Nuclear Information System (INIS)

    Park, Byeong Hyeon; Kim, Yong Kyun; Kang, Jeong Soo; Kim, Young Jin; Choi, Ihn Jea; Kim, Chong; Hong, Byung Sik

    2011-01-01

    The PHENIX Experiment is the largest of the four experiments that have taken data at the Relativistic Heavy Ion Collider. PHENIX, the Pioneering High Energy Nuclear Interaction eXperiment, is designed specifically to measure direct probes of the collisions such as electrons, muons, and photons. The primary goal of PHENIX is to discover and study a new state of matter called the Quark-Gluon Plasma. Among many particles, muons coming from W-boson decay gives us key information to analyze the spin of proton. Resistive plate chambers are proposed as a suitable solution as a muon trigger because of their fast response and good time resolution, flexibility in signal readout, robustness and the relatively low cost of production. The RPC detectors for upgrade were assembled and their performances were evaluated. The procedure to make the detectors better was optimized and described in detail in this thesis. The code based on ROOT was written and by using this the performance of the detectors made was evaluated, and all of the modules for north muon arm met the criteria and installation at PHENIX completed in November 2009. As RPC detectors that we made showed fast response, capacity of covering wide area with a resonable price and good spatial resolution, this will give the opportunity for applications, such as diagnosis and customs inspection system

  20. Development and evaluation of the muon trigger detector using a resistive plate chamber

    International Nuclear Information System (INIS)

    Park, Byeong Hyeon

    2010-08-01

    The PHENIX Experiment is the largest of the four experiments that have taken data at the Relativistic Heavy Ion Collider. PHENIX, the Pioneering High Energy Nuclear Interaction experiment, is an exploratory experiment for the investigation of high energy collisions of heavy ions and protons. PHENIX is designed specifically to measure direct probes of the collisions such as electrons, muons, and photons. The primary goal of PHENIX is to discover and study a new state of matter called the Quark-Gluon Plasma. Among many particles, muons coming from W-boson decay gives us key information to analyze the spin of proton. Resistive plate chambers are proposed as a suitable solution as a muon trigger because of their fast response and good time resolution, flexibility in signal readout, robustness and the relatively low cost of production. The RPC detectors for upgrade were assembled and their performances were evaluated. The procedure to make the detectors better was optimized and described in detail in this thesis. The code based on ROOT was written and by using this the performance of the detectors made was evaluated, and all of the modules for north muon arm met the criteria and installation at PHENIX completed in November 2009. As RPC detectors that we made showed fast response, capacity of covering wide area with a resonable price and good spatial resolution, this will give the opportunity for applications,such as diagnosis and customs inspection system

  1. Recent developments with microchannel-plate PMTs

    Science.gov (United States)

    Lehmann, A.; Böhm, M.; Britting, A.; Eyrich, W.; Pfaffinger, M.; Uhlig, F.; Belias, A.; Dzhygadlo, R.; Gerhardt, A.; Götzen, K.; Kalicy, G.; Krebs, M.; Lehmann, D.; Nerling, F.; Patsyuk, M.; Peters, K.; Schepers, G.; Schmitt, L.; Schwarz, C.; Schwiening, J.; Traxler, M.; Zühlsdorf, M.; Düren, M.; Etzelmüller, E.; Föhl, K.; Hayrapetyan, A.; Kröck, B.; Merle, O.; Rieke, J.; Schmidt, M.; Wasem, T.; Cowie, E.; Keri, T.; Achenbach, P.; Cardinali, M.; Hoek, M.; Lauth, W.; Schlimme, S.; Sfienti, C.; Thiel, M.

    2017-12-01

    Microchannel-plate (MCP) PMTs are the favored photon sensors for the DIRC detectors of the PANDA experiment at FAIR. Until recently the main drawback of MCP-PMTs were serious aging effects which led to a limited lifetime due to a rapidly decreasing quantum efficiency (QE) of the photo cathode (PC) as the integrated anode charge (IAC) increased. In the latest models of PHOTONIS and Hamamatsu an innovative atomic layer deposition (ALD) technique is applied to overcome these limitations. During the last five years comprehensive aging tests with ALD coated MCP-PMTs were performed and the results were compared to tubes treated with other techniques. The QE in dependence of the IAC was measured as a function of the wavelength and the position across the PC. For the best performing tubes the lifetime improvement in comparison to the older MCP-PMTs is a factor of > 50 based on an IAC of meanwhile > 10 C /cm2 . In addition, the performance results of a new 2-in. ALD coated MCP-PMT prototype from Hamamatsu with a very high position resolution (128×6 anode pixels) is presented and the first conclusions from investigations concerning the PC aging mechanism will be discussed.

  2. Development of noise-suppressed detector for single ion hit system

    Energy Technology Data Exchange (ETDEWEB)

    Sakai, Takuro; Hamano, Tsuyoshi; Suda, Tamotsu; Hirao, Toshio; Kamiya, Tomihiro [Japan Atomic Energy Research Inst., Takasaki, Gunma (Japan). Takasaki Radiation Chemistry Research Establishment

    1997-03-01

    A noise-suppressed detector for single ion detection has been developed, and combined with the heavy ion microbeam apparatus. This detector consists of a pair of micro channel plates (MCP`s) and a very thin carbon foil. The detection signal is formed by the coincidence of the signals from these MCP`s, so that this detector and the coincidence measurement unit can reduce miscounting in the circuit. The detection efficiency for 15 MeV heavy ions was evaluated to be comparable to that of a silicon surface-barrier detector (SSD) and the miscounting rate was 4 orders lower than the noise rate of a single MCP. The rise time of the detection signal was also estimated. (author)

  3. Calculating and optimizing inter-electrode capacitances of charge division microchannel plate detectors

    Energy Technology Data Exchange (ETDEWEB)

    Xing, Yan [Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun 130033 (China); University of Chinese Academy of Sciences, Beijing 100049 (China); Chen, Bo, E-mail: chenb@ciomp.ac.cn [Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun 130033 (China); Zhang, Hong-Ji; Wang, Hai-Feng; He, Ling-Ping [Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun 130033 (China); Jin, Fang-Yuan [Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun 130033 (China); University of Chinese Academy of Sciences, Beijing 100049 (China)

    2016-04-01

    Based on the principle of charge division microchannel plate detectors, the inter-electrode capacitances of charge division anodes which are related to electronic noise of the charge sensitive amplifier and crosstalk effect of the anode are presented. Under all the requirements of charge division microchannel plate detectors such as the imaging linearity and spatial resolution, decreasing the inter-electrode capacitances is one way to improve the imaging performance. In this paper, we illustrate the simulation process of calculating the inter-electrode capacitances. Moreover, a Wedge and Strip (WSZ) anode is fabricated with the picosecond laser micromachining process. Comparing the simulated capacitances and measured capacitances, the three-dimensional finite element method is proved to be valid. Furthermore, by adjusting the design parameters of the anode, the effects of the substrate permittivity, insulation width and the size of pitch on the inter-electrode capacitances have been analysed. The structure of the charge division anode has been optimized based on the simulation data.

  4. The Resistive-Plate WELL with Argon mixtures - a robust gaseous radiation detector

    CERN Document Server

    Moleri, Luca; Arazi, Lior; Rocha Azevedo, Carlos Davide; Oliveri, Eraldo; Pitt, Michael; Schaarschmidt, Jana; Shaked-Renous, Dan; Marques Ferreira dos Santos, Joaquim; Veloso, Joao Filipe Calapez de Albuquerque; Breskin, Amos; Bressler, Shikma

    2017-01-01

    A thin single-element THGEM-based, Resistive-Plate WELL (RPWELL) detector was operated with 150 GeV/c muon and pion beams in Ne/(5%CH$_4$), Ar/(5%CH$_4$) and Ar/(7%CO$_2$); signals were recorded with 1 cm$^2$ square pads and SRS/APV25 electronics. Detection efficiency values greater than 98% were reached in all the gas mixtures, at average pad multiplicity of 1.2. The use of the 10$^9${\\Omega}cm resistive plate resulted in a completely discharge-free operation also in intense pion beams. The efficiency remained essentially constant at 98-99% up to fluxes of $\\sim$10$^4$Hz/cm$^2$, dropping by a few % when approaching 10$^5$ Hz/cm$^2$. These results pave the way towards cost-effective, robust, efficient, large-scale detectors for a variety of applications in future particle, astro-particle and applied fields. A potential target application is digital hadron calorimetry.

  5. A new miniature microchannel plate X-ray detector for synchrotron radiation

    International Nuclear Information System (INIS)

    Rosemeier, R.G.; Green, R.E. Jr.

    1982-01-01

    A state-of-the-art microchannel plate detector has been developed which allows real time X-ray imaging of X-ray diffraction as well as radiographic phenomenon. Advantages of the device include a 50 mm X-ray input, length less than 4'', and a weight of less than 1 lb. Since the use of synchrotron radiation is greatly facilitated by the capability of remote viewing of X-ray diffraction or radiographic images in real time, a prototype electro-optical system has been designed which couples the X-ray microchannel plate detector with a solid state television camera. Advantages of the miniature, lightweight, X-ray synchrotron camera include a large 50 mm X-ray input window, an output signal that is available in both analog format for display on a television monitor and in digital format for computer processing, and a completely modular design which allows all the components to be exchanged for other components optimally suited for the desired applications. (orig.)

  6. Neutron radiography of thick hydrogenous materials with use of an imaging plate neutron detector

    International Nuclear Information System (INIS)

    Kato, K.; Matsumoto, G.; Karasawa, Y.; Niimura, N.; Matsubayashi, M.; Tsuruno, A.

    1996-01-01

    The value of the neutron mass attenuation coefficient of hydrogen being very high, it is extremely difficult to image normal size, living animals with neutron radiography. However, the authors suggest the possibility of applying neutron radiography for biomedical specimens. The organs in the breast, bones and cartilages in the extremities, and the tail of mice and rats were clearly imaged by neutron radiography with Gd foils as neutron converters and X-ray films. However, no contours of the organs in the mouse abdomen were visible with neutron radiography with an exposure time of 200 s. By adding Gd or Li compounds as neutron converters to imaging X-ray plates, imaging plates have been developed for neutron detectors. A trial using these imaging plates for neutron radiography of water-filled containers and the abdomen of mice was completed. The roundness of a 100 ml-beaker was imaged with a neutron exposure of 180 s. Obscure contours of the liver and kidneys of the mouse were imaged with a neutron exposure of 100 s. (orig.)

  7. Testing micro-channel plate detectors for the particle identification upgrade of LHCb

    CERN Document Server

    Castillo Garcia, L

    2012-01-01

    The TORCH, Time of internally Reflected Cherenkov Light, is proposed for the high luminosity upgrade of the LHCb experiment. The detector combines Time-of-Flight and Cherenkov techniques to achieve positive pi/K/p separation on a >= 3 sigma level in the momentum range below 10 GeV/c. The required time resolution is <= 50 ps for single photon signal. In a preliminary R\\&D phase, we have shown that already commercially available micro-channel plate tubes with 8 x 8 channels fulfil the requirements. Timing properties of the tubes have been investigated with a pulsed laser diode in single photon regime. Key results from these laboratory tests are reported. An excellent timing resolution of <40 ps is achieved with an efficiency of similar to 90\\%. (C) 2011 Elsevier B.V. All rights reserved.

  8. Testing of multigap Resistive Plate Chambers for Electron Ion Collider Detector Development

    Science.gov (United States)

    Hamilton, Hannah; Phenix Collaboration

    2015-10-01

    Despite decades of research on the subject, some details of the spin structure of the nucleon continues to be unknown. To improve our knowledge of the nucleon spin structure, the construction of a new collider is needed. This is one of the primary goals of the proposed Electron Ion Collider (EIC). Planned EIC spectrometers will require good particle identification. This can be provided by time of flight (TOF) detectors with excellent timing resolutions of 10 ps. A potential TOF detector that could meet this requirement is a glass multigap resistive plate chamber (mRPC). These mRPCs can provide excellent timing resolution at a low cost. The current glass mRPC prototypes have a total of twenty 0.1 mm thick gas gaps. In order to test the feasibility of this design, a cosmic test stand was assembled. This stand used the coincidence of scintillators as a trigger, and contains fast electronics. The construction, the method of testing, and the test results of the mRPCs will be presented.

  9. 'Zero-time' detectors using microchannel plates for charged particle detection

    International Nuclear Information System (INIS)

    Girard, J.

    1977-01-01

    The mass identification of the reaction products detected in heavy ion nuclear reactions is generally obtained by the time-of-flight method. This method requires a device giving first the 'start' signal (zero time at the passage of the particle) and then the stop 'signal'. The interest lying in 'zero-time' detectors using a secondary electron emission has been considerably increased with using microchannel electron multipliers. Nevertheless such a device was shown to induce either fluctuations in the distance of flight or the use of detectors of different type in the 'start' and 'stop' channels respectively. In both cases, it remains an ambiguity as the access to time resolution, in the channel including the electron multiplier, is not direct and the effect of the different parameters on this resolution are masked. To palliate this drawback and study the qualities of microchannel plate multipliers in time measurement field, some devices mechanically and electronically symmetric have been developed. The resolution measurement in time of flight is obtained for electrons generated by the same particle and emitted from either side of a thin film. The distances of flight of the electrons on each side of the film are same, and so are the accelerating potentials. The microchannel electron multipliers and the processing electronic units are the same in each channel [fr

  10. An alpha particle detector based on a GPS mosaic scintillator plate for continuous air monitoring in plutonium handling facilities

    International Nuclear Information System (INIS)

    Kaneko, Junichi H.; Izaki, Kenji; Toui, Kouhei; Shimaoka, Takehiro; Morishita, Yuki; Tsubota, Youichi; Higuchi, Mikio

    2016-01-01

    An alpha particle detector was developed for continuous air monitoring of radioactive contamination in working chambers at plutonium handling facilities. A 5-cm-square Gd 2 Si 2 O 7 :Ce (cerium-doped gadolinium pyro-silicate, GPS:Ce) mosaic scintillator plate for alpha particle measurements was fabricated from GPS single-crystal grains of around 550 μm diameter; the GPS grains were made of a GPS polycrystalline body grown using a top seeded solution method. The scintillator layer thickness was approximately 100 μm. The surface filling rate of the GPS grains was ca. 62%. To suppress the influence of non-uniformity of pulse heights of a photomultiplier tube, a central part of ∅ 40 mm of a 76-mm-diameter photomultiplier tube was used. In addition, 3 mm thick high-transmission glass was used as a substrate of the scintillator plate. The detector achieved energy resolution of 13% for 5.5 MeV alpha particles, detection efficiency of 61% and a radon progeny nuclide reduction ratio of 64.5%. A new alpha particle detector was developed to achieve a high radon progeny nuclide reduction ratio approaching that of a silicon semiconductor detector, with high resistance to electromagnetic noise and corrosion. - Highlights: • An alpha particle detector was developed for continuous air monitoring. • The detector comprises a mosaic scintillator plate and a photomultiplier tube. • A 5-cm-square GPS mosaic scintillator plate was fabricated. • Its respective energy resolution and detection efficiency were 13 and 61%. • The radon progeny nuclide reduction ratio of the developed detector was 64.5%.

  11. Coordinate-sensitive charged particle detector for spectroscopy

    Directory of Open Access Journals (Sweden)

    Sidorenko V. P.

    2016-10-01

    Full Text Available The authors have designed, manufactured and tested a coordinate-sensitive detector for charged particle spectroscopy. The detector can be used in the devices for the elemental analysis of materials, providing simultaneous analysis of all the elemental composition with high sensitivity and precision. The designed device is based on an integrated circuit (IC and a microchannel plate (MCP electron multiplier. The IC is mounted on a ceramic substrate. Ions fall on the MCP mounted above the IC. Giving rise to a pulse which typically exceeds 106 electrons, each ion falls on the detector electrodes and these pulses are counted. In this research, a two stage stack of MCPs (Hamamatsu was used. The MCPs have a channel diameter of 12 μm on a 15 μm pitch. The results of tests carried out in a mass spectrometer are presented. The designed detector is small, light, and low-power.

  12. A timing detector with pulsed high-voltage power supply for mass measurements at CSRe

    International Nuclear Information System (INIS)

    Zhang, W.; Tu, X.L.; Wang, M.; Zhang, Y.H.; Xu, H.S.; Litvinov, Yu. A.; Blaum, K.

    2014-01-01

    Accuracy of nuclear mass measurements in storage rings depends critically on the accuracy with which the revolution times of stored ions can be obtained. In such experiments, micro-channel plates (MCP) are used as timing detectors. Due to large phase space of injected secondary beams, a large number of ions cannot be stored in the ring and is lost within the first few revolutions. However, these ions interact with the detector and can saturate the MCP and thus deteriorate its performance. In order to eliminate such effects, a fast, pulsed high-voltage power supply (PHVPS) has been employed which keeps the detector switched-off during the first few revolutions. The new detector setup was taken into operation at the Experimental Cooler-Storage-Ring CSRe in Lanzhou and resulted in a significant improvement of the detector amplitude and efficiency characteristics

  13. Measurements of recent microchannel-plate photomultipliers with significantly increased lifetime

    Energy Technology Data Exchange (ETDEWEB)

    Uhlig, Fred; Eyrich, Wolfgang; Lehmann, Albert; Britting, Alexander [Universitaet Erlangen, Physikal. Institut IV (Germany); Collaboration: PANDA-Collaboration

    2015-07-01

    Microchannel-plate photomultipliers (MCP-PMTs) are the favored sensors for the DIRC detectors (Detection of Internally Reflected Cherenkov Light) of the PANDA experiment. They are usable in high magnetic fields of up to 2T and reach a time resolution of better than 50 ps (σ). The anticipated average luminosity of 2.10{sup 32} cm{sup -2} s{sup -1} in the detector requires a rate capability high enough to withstand a detected photon rate of about 200 kHz cm{sup -2} at the MCP-PMT surfaces. The major drawback until recently was the limited lifetime of MCP-PMTs, which appears to be solved for the latest generation of MCP-PMT prototype devices. The aging parameter is the quantum efficiency as a function of the integrated anode charge, which will be in the region of 5 C/cm{sup 2} for the Barrel- and the Disc-DIRC. We simultaneously measured the aging of several MCP-PMTs, which were treated with different methods to enhance the lifetime. Results of these measurements are presented.

  14. Uses of microchannel plate intensified detectors for imaging applications in the X-ray, EUV and visible wavelength regions

    International Nuclear Information System (INIS)

    Read, P.D.; Carter, M.K.; Pike, C.D.; Harrison, R.A.; Kent, B.J.; Swinyard, B.M.; Patchett, B.E.; Redfern, R.M.; Shearer, A.; Colhoun, M.

    1997-01-01

    The Rutherford Appleton laboratory photon counting detector (RALPCD) has been refined to meet project requirements for a flexible imaging arrangement with applications at X-ray, EUV and visible wavelengths. The basic detector design comprises commercially available high gain microchannel plate intensifiers fibre optically coupled to CID or CCD cameras, to form a modular detector arrangement with the appropriate RAL detection and centroiding software. Frames of data from the cameras are detected and centroided in a transputer or C40 parallel processor array where correction algorithms use look up tables to produce pattern free images at high resolution. Data from completed applications are used to illustrate the performance and future advances are discussed. (orig.)

  15. A 30 ps Timing Resolution for Single Photons with Multi-pixel Burle MCP-PMT

    Energy Technology Data Exchange (ETDEWEB)

    Va' vra, J.; Benitez, J.; Coleman, J.; Leith, D.W.G.S.; Mazaheri, G.; Ratcliff, B.; Schwiening, J.; /SLAC

    2006-07-05

    We have achieved {approx}30 psec single-photoelectron and {approx}12ps for multi-photoelectron timing resolution with a new 64 pixel Burle MCP-PMT with 10 micron microchannel holes. We have also demonstrated that this detector works in a magnetic field of 15kG, and achieved a single-photoelectron timing resolution of better than 60 psec. The study is relevant for a new focusing DIRC RICH detector for particle identification at future Colliders such as the super B-factory or ILC, and for future TOF techniques. This study shows that a highly pixilated MCP-PMT can deliver excellent timing resolution.

  16. Low energy electron microscopy imaging using Medipix2 detector

    International Nuclear Information System (INIS)

    Sikharulidze, I.; Gastel, R. van; Schramm, S.; Abrahams, J.P.; Poelsema, B.; Tromp, R.M.; Molen, S.J. van der

    2011-01-01

    Low Energy Electron Microscopy (LEEM) and Photo-Emission Electron Microscopy (PEEM) predominantly use a combination of microchannel plate (MCP), phosphor screen and optical camera to record images formed by 10-20 keV electrons. We have tested the performance of a LEEM/PEEM instrument with a Medipix2 hybrid pixel detector using an Ir(1 1 1) sample with graphene flakes grown on its surface. We find that Medipix2 offers a number of advantages over the MCP. The adjustable threshold settings allow Medipix2 to operate as a noiseless detector, offering an improved signal-to-noise ratio for the same amount of signal compared to the MCP. At the same magnification Medipix2 images exhibit superior resolution and can handle significantly higher electron current densities than an MCP, offering the prospect of substantially higher frame rates in LEEM imaging. These factors make Medipix2 an excellent candidate to become the detector of choice for LEEM/PEEM applications.

  17. Low energy electron microscopy imaging using Medipix2 detector

    Energy Technology Data Exchange (ETDEWEB)

    Sikharulidze, I., E-mail: irakli@chem.leidenuniv.nl [Leiden Institute of Chemistry, Leiden University, P.O. Box 9502, 2300RA Leiden (Netherlands); Gastel, R. van [MESA Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500AE Enschede (Netherlands); Schramm, S. [Kamerlingh Onnes Laboratory, Leiden University, P.O. Box 9504, 2300RA Leiden (Netherlands); Abrahams, J.P. [Leiden Institute of Chemistry, Leiden University, P.O. Box 9502, 2300RA Leiden (Netherlands); Poelsema, B. [MESA Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500AE Enschede (Netherlands); Tromp, R.M. [Kamerlingh Onnes Laboratory, Leiden University, P.O. Box 9504, 2300RA Leiden (Netherlands); IBM Research Division, T. J. Watson Research Center, P.O. Box 218, Yorktown Heights, NY 10598 (United States); Molen, S.J. van der [Kamerlingh Onnes Laboratory, Leiden University, P.O. Box 9504, 2300RA Leiden (Netherlands)

    2011-05-15

    Low Energy Electron Microscopy (LEEM) and Photo-Emission Electron Microscopy (PEEM) predominantly use a combination of microchannel plate (MCP), phosphor screen and optical camera to record images formed by 10-20 keV electrons. We have tested the performance of a LEEM/PEEM instrument with a Medipix2 hybrid pixel detector using an Ir(1 1 1) sample with graphene flakes grown on its surface. We find that Medipix2 offers a number of advantages over the MCP. The adjustable threshold settings allow Medipix2 to operate as a noiseless detector, offering an improved signal-to-noise ratio for the same amount of signal compared to the MCP. At the same magnification Medipix2 images exhibit superior resolution and can handle significantly higher electron current densities than an MCP, offering the prospect of substantially higher frame rates in LEEM imaging. These factors make Medipix2 an excellent candidate to become the detector of choice for LEEM/PEEM applications.

  18. The TORCH time-of-flight detector

    Energy Technology Data Exchange (ETDEWEB)

    Harnew, N., E-mail: Neville.Harnew@physics.ox.ac.uk [University of Oxford, Denys Wilkinson Building, 1 Keble Road, Oxford OX1 3RH (United Kingdom); Brook, N. [University College London, Department of Physics & Astronomy, Gower Street, London WC1E 6BT (United Kingdom); Castillo García, L. [CERN, PH Department, CH-1211 Geneva 23 (Switzerland); Laboratory for High Energy Physics, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne (Switzerland); Cussans, D. [H.H. Wills Physics Laboratory, University of Bristol, Bristol BS8 1TL (United Kingdom); Föhl, K.; Forty, R.; Frei, C. [CERN, PH Department, CH-1211 Geneva 23 (Switzerland); Gao, R. [University of Oxford, Denys Wilkinson Building, 1 Keble Road, Oxford OX1 3RH (United Kingdom); Gys, T.; Piedigrossi, D. [CERN, PH Department, CH-1211 Geneva 23 (Switzerland); Rademacker, J.; Ros Garcia, A.; Dijk, M. van [H.H. Wills Physics Laboratory, University of Bristol, Bristol BS8 1TL (United Kingdom)

    2016-07-11

    The TORCH time-of-flight detector is being developed to provide particle identification between 2 and 10 GeV/c momentum over a flight distance of 10 m. TORCH is designed for large-area coverage, up to 30 m{sup 2}, and has a DIRC-like construction. The goal is to achieve a 15 ps time-of-flight resolution per incident particle by combining arrival times from multiple Cherenkov photons produced within quartz radiator plates of 10 mm thickness. A four-year R&D programme is underway with an industrial partner (Photek, UK) to produce 53×53 mm{sup 2} Micro-Channel Plate (MCP) detectors for the TORCH application. The MCP-PMT will provide a timing accuracy of 40 ps per photon and it will have a lifetime of up to at least 5 Ccm{sup −2} of integrated anode charge by utilizing an Atomic Layer Deposition (ALD) coating. The MCP will be read out using charge division with customised electronics incorporating the NINO chipset. Laboratory results on prototype MCPs are presented. The construction of a prototype TORCH module and its simulated performance are also described.

  19. New technologies for UV detectors

    Science.gov (United States)

    Joseph, C. L.

    1993-01-01

    Several technologies are currently being developed, leading to substantial improvements in the performance of UV detectors or significant reductions in power or weight. Four technologies discussed are (1) thin-film coatings to enhance the UV sensitivity of CCD's, (2) highly innovative magnet assemblies that dramatically reduce weight and result in virtually no external flux, (3) new techniques for curving microchannel plates (MCP's) so that single plates can be used to prevent ion feedback and present highly localized charge clouds to an anode structure, and (4) high-performance alternatives to glass-based MCP's. In item (2), for example, very robust magnets are made out of rare earth materials such as samarium cobalt, and cladding magnets are employed to prevent flux from escaping from the detector into the external environment. These new ultralight magnet assemblies are able to create strong, exceptionally uniform magnetic fields for image intensification and focusing of photoelectrons. The principle advantage of such detectors is the quantum efficiencies of 70-80 percent obtained throughout ultraviolet wavelengths (900-2000 A), the highest of any device. Despite the improvements achieved under item (3), high-performance alternatives to conventional glass-based MCP's potentially offer three distinct new advantages that include (1) a 30-100-fold improvement in dynamic range resulting in correspondingly higher signal-to-noise ratios, (2) the use of pure dielectric and semiconductor materials that will not outgas contaminants that eventually destroy photocathodes, and (3) channels that have constant spacing providing long-ranged order since the plates are made using photolithography techniques from the semiconductor industry. The manufacturers of these advanced-technology MCP's, however, are a couple of years away from actually producing a functioning image intensifier. In contrast to the use of CCD's for optical, ground based observations, there is no single

  20. A High Position Resolution X-ray Detector: an Edge on Illuminated Capillary Plate Combined with a Gas Amplification Structure

    CERN Document Server

    Iacobaeus, C.; Lund-Jensen, B.; Ostling, J.; Pavlopoulos, P.; Peskov, V.; Tokanai, F.

    2006-01-01

    We have developed and successfully tested a prototype of a new type of high position resolution hybrid X-ray detector. It contains a thin wall lead glass capillary plate converter of X-rays combined with a microgap parallel-plate avalanche chamber filled with gas at 1 atm. The operation of these converters was studied in a wide range of X-ray energies (from 6 to 60 keV) at incident angles varying from 0-90 degree. The detection efficiency, depending on the geometry, photon energy, incident angle and the mode of operation, was between 5-30 percent in a single step mode and up to 50 percent in a multi-layered combination. Depending on the capillary geometry, the position resolution achieved was between 0.050-0.250 mm in digital form and was practically independent of the photon energy or gas mixture. The usual lead glass capillary plates operated without noticeable charging up effects at counting rates of 50 Hz/mm2, and hydrogen treated capillaries up to 10E5 Hz/mm2. The developed detector may open new possibil...

  1. Optimization of the electron collection efficiency of a large area MCP-PMT for the JUNO experiment

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Lin, E-mail: chenlin@opt.cn [State Key Laboratory of Transient Optics and Photonics, Xi’an Institute of Optics and Precision Mechanics (XIOPM), Chinese Academy of Sciences (CAS), Xi’an 710119 (China); Graduate School of Chinese Academy of Sciences (CAS), Beijing 100049 (China); Xi’an Jiaotong University, Xi’an 710049 (China); Tian, Jinshou [Graduate School of Chinese Academy of Sciences (CAS), Beijing 100049 (China); Liu, Chunliang [Xi’an Jiaotong University, Xi’an 710049 (China); Wang, Yifang; Zhao, Tianchi [Institute of High Energy Physics (IHEP) of CAS, Beijing 100049 (China); Liu, Hulin; Wei, Yonglin; Sai, Xiaofeng [Graduate School of Chinese Academy of Sciences (CAS), Beijing 100049 (China); Chen, Ping [State Key Laboratory of Transient Optics and Photonics, Xi’an Institute of Optics and Precision Mechanics (XIOPM), Chinese Academy of Sciences (CAS), Xi’an 710119 (China); Graduate School of Chinese Academy of Sciences (CAS), Beijing 100049 (China); Wang, Xing; Lu, Yu [Graduate School of Chinese Academy of Sciences (CAS), Beijing 100049 (China); Hui, Dandan; Guo, Lehui [State Key Laboratory of Transient Optics and Photonics, Xi’an Institute of Optics and Precision Mechanics (XIOPM), Chinese Academy of Sciences (CAS), Xi’an 710119 (China); Graduate School of Chinese Academy of Sciences (CAS), Beijing 100049 (China); Liu, Shulin; Qian, Sen; Xia, Jingkai; Yan, Baojun; Zhu, Na [Institute of High Energy Physics (IHEP) of CAS, Beijing 100049 (China); Sun, Jianning; Si, Shuguang [North Night Vision Technology (NNVT) CO., LTD, Nanjing 210110 (China); and others

    2016-08-11

    A novel large-area (20-inch) photomultiplier tube based on microchannel plate (MCP-PMTs) is proposed for the Jiangmen Underground Neutrino Observatory (JUNO) experiment. Its photoelectron collection efficiency C{sub e} is limited by the MCP open area fraction (A{sub open}). This efficiency is studied as a function of the angular (θ), energy (E) distributions of electrons in the input charge cloud and the potential difference (U) between the PMT photocathode and the MCP input surface, considering secondary electron emission from the MCP input electrode. In CST Studio Suite, Finite Integral Technique and Monte Carlo method are combined to investigate the dependence of C{sub e} on θ, E and U. Results predict that C{sub e} can exceed A{sub open}, and are applied to optimize the structure and operational parameters of the 20-inch MCP-PMT prototype. C{sub e} of the optimized MCP-PMT is expected to reach 81.2%. Finally, the reduction of the penetration depth of the MCP input electrode layer and the deposition of a high secondary electron yield material on the MCP are proposed to further optimize C{sub e}.

  2. Optimization of the electron collection efficiency of a large area MCP-PMT for the JUNO experiment

    International Nuclear Information System (INIS)

    Chen, Lin; Tian, Jinshou; Liu, Chunliang; Wang, Yifang; Zhao, Tianchi; Liu, Hulin; Wei, Yonglin; Sai, Xiaofeng; Chen, Ping; Wang, Xing; Lu, Yu; Hui, Dandan; Guo, Lehui; Liu, Shulin; Qian, Sen; Xia, Jingkai; Yan, Baojun; Zhu, Na; Sun, Jianning; Si, Shuguang

    2016-01-01

    A novel large-area (20-inch) photomultiplier tube based on microchannel plate (MCP-PMTs) is proposed for the Jiangmen Underground Neutrino Observatory (JUNO) experiment. Its photoelectron collection efficiency C e is limited by the MCP open area fraction (A open ). This efficiency is studied as a function of the angular (θ), energy (E) distributions of electrons in the input charge cloud and the potential difference (U) between the PMT photocathode and the MCP input surface, considering secondary electron emission from the MCP input electrode. In CST Studio Suite, Finite Integral Technique and Monte Carlo method are combined to investigate the dependence of C e on θ, E and U. Results predict that C e can exceed A open , and are applied to optimize the structure and operational parameters of the 20-inch MCP-PMT prototype. C e of the optimized MCP-PMT is expected to reach 81.2%. Finally, the reduction of the penetration depth of the MCP input electrode layer and the deposition of a high secondary electron yield material on the MCP are proposed to further optimize C e .

  3. Measurement of negative ion mobility in O2 at high pressures using a point plate gap as an ion detector

    International Nuclear Information System (INIS)

    Okuyama, Y; Kimura, T; Suzuki, S; Itoh, H

    2012-01-01

    This paper describes the experimental results for negative ion mobility in O 2 at 0.5-2.0 atm. The ion mobility is observed using a high-pressure ion drift tube with a positive corona gap (Geiger counter), which is constructed from a point plate gap and acts as a negative ion detector. The variation of waveforms in the burst pulse is observed by varying the voltage applied to the ion detector to find the optimum voltage that must be applied across the ion detector in O 2 . This is investigated carefully to ensure the precise determination of mobility. The distortion of the electric field near the mesh electrode, which operates as the cathode of the ion detector and as the anode of the ion drift gap, is then examined to determine the optimum applied voltage to suppress its effect on the measurement of mobility. The mobility is subsequently measured at a reduced electric field intensity of 2.83 × 10 -3 to 2.83. The observed mobility of 2.31 ± 0.03 cm 2 V -1 s -1 in O 2 is concluded to be that of O 2 - . This value is also obtained in experiments over a wide range of gas pressures (0.5-2.0 atm) and drift lengths (1.00-9.00 cm). The mobilities of O 3 - and O - are also obtained experimentally. (paper)

  4. Applications and characteristics of imaging plates as detector in neutron radiography at SINQ

    CERN Document Server

    Kolbe, H; Gunia, W; Körner, S

    1999-01-01

    Imaging plate technique is a commonly accepted method in many fields as in medicine, biology and physics for detection of the distribution of beta- and gamma-radiation or X-rays on large areas. Recently a new type of imaging plate sensitive to neutrons has been developed. The storage layer is doped with gadolinium, which, after absorption of neutrons, produces radiation detectable by the same sensitive crystals used in conventional imaging plates. At the spallation neutron source, SINQ, at the Paul Scherrer Institut (CH) some of the characteristics of the neutron radiography station in combination with the imaging plate technique were investigated. The intensity distribution of the source was measured to check the accuracy for quantification of the image data. Also, the reproducibility of results obtained by this detection system was stated. For a test object, the high selectivity for different neutron absorption is demonstrated at details with low contrast. The obtainable spatial resolution was determined re...

  5. Understanding the dynamic performance of microchannel plates in pulsed mode

    International Nuclear Information System (INIS)

    Ray Thomas; Ming Wu; Nathan Joseph; Craig Kruschwitz; Gregroy A. Rochau

    2007-01-01

    The dynamic performance of a microchannel plate (MCP) is highly dependent on the high-voltage waveforms that are applied to it. Impedance mismatches in MCP detectors can significantly vary the waveforms on the MCP compared to the input pulses. High-voltage pulse waveforms launched onto surface coatings on the MCPs have historically been difficult and expensive to measure. Over the past few years, we have developed and tested techniques utilizing probes to measure the voltage propagation on the surface of MCPs. Square and Gaussian pulses with widths ranging from 200 ps to 2 ns have been applied. We have investigated the effects of coating thickness, microstrip width, and openended versus terminated strips. These data provide a wealth of knowledge that is enabling a better understanding of images recorded with these devices. This presentation discusses a method for measuring voltage profiles on the surface of the MCP and presents Monte Carlo simulations of the optical gate profiles based on the measured waveforms. Excellent agreement in the optical gate profiles have been achieved between the simulations and the experimental measurements using a short-pulse ultraviolet laser

  6. Significantly increased lifetime of recent microchannel-plate photomultipliers

    Energy Technology Data Exchange (ETDEWEB)

    Britting, Alexander; Eyrich, Wolfgang; Lehmann, Albert; Uhlig, Fred [Physikalisches Institut, Universitaet Erlangen-Nuernberg (Germany)

    2013-07-01

    Micro-channel plate photo multipliers (MCP-PMT) are the favored sensors for the DIRC detectors (Detection of Internally Reflected Cherenkov Light) of the PANDA experiment. The main reasons for this are their usability in high magnetic fields of up to 2 T, a time resolution of better than σ = 50 ps and a rate capability high enough to withstand a detected photon rate of about 200 kHz cm{sup -2} at the MCP-PMTs surface, which is anticipated at the average luminosity of 2 . 10{sup 32} cm{sup -2}s{sup -1} in PANDA. Moreover, for the reconstruction of the Cherenkov angle using the planned optics for the barrel DIRC a spatial resolution of about 5 mm at the focal plane is needed. Until recently the major drawback of MCP-PMTs was their limited lifetime which was by far not sufficient to stand the integrated anode charge, which is ∼ 5 C/cm{sup 2} for the Barrel-DIRC and even more for the Disc-DIRC. However, the latest MCP prototype devices show a hugh step forward in this respect. The results of these lifetime measurements are presented. The achieved values are meanwhile close to the PANDA requirements for the Barrel-DIRC.

  7. Development of microchannel plates in advanced wind-tunnel instrumentation

    Science.gov (United States)

    Feller, W. Bruce

    1990-01-01

    Microchannel plate (MCP) electron multiplier dynamic range has been increased 3 to 4 orders of magnitude at ambient temperatures, through enhanced input count rate capability and reduced background or 'dark' noise. The previous upper limit of roughly 10(exp 7) - 10(exp 8) cm(exp -2)s(exp -1) at ambient has been extended to levels approach 10(exp 10) cm(exp -2)s(exp -1) under continuous dc operation. The lower limit, previously set by an irreducible background component (approximately 0.6 cm(exp -2)s(exp -1)), has been lowered to the cosmic ray limit of .01 cm(exp -2)s(exp -1). The high end improvement was achieved by conductively cooling a very low resistance MCP by bonding it to a heat sink, while maintaining pulse-counting operation with multianode readouts. The low-end improvement was achieved by removing all radioisotopes from the MCP matrix glass. The detectors will benefit optical and mass spectrometry, flow visualization, plasma diagnostics, magnetometry, and other high signal flux applications. Very low MCP background noise will benefit X-ray and UV astronomy, medical imaging, trace isotope mass spectrometry, and other applications where the signal flux is often extremely low.

  8. An algorithm for automatic crystal identification in pixelated scintillation detectors using thin plate splines and Gaussian mixture models.

    Science.gov (United States)

    Schellenberg, Graham; Stortz, Greg; Goertzen, Andrew L

    2016-02-07

    A typical positron emission tomography detector is comprised of a scintillator crystal array coupled to a photodetector array or other position sensitive detector. Such detectors using light sharing to read out crystal elements require the creation of a crystal lookup table (CLUT) that maps the detector response to the crystal of interaction based on the x-y position of the event calculated through Anger-type logic. It is vital for system performance that these CLUTs be accurate so that the location of events can be accurately identified and so that crystal-specific corrections, such as energy windowing or time alignment, can be applied. While using manual segmentation of the flood image to create the CLUT is a simple and reliable approach, it is both tedious and time consuming for systems with large numbers of crystal elements. In this work we describe the development of an automated algorithm for CLUT generation that uses a Gaussian mixture model paired with thin plate splines (TPS) to iteratively fit a crystal layout template that includes the crystal numbering pattern. Starting from a region of stability, Gaussians are individually fit to data corresponding to crystal locations while simultaneously updating a TPS for predicting future Gaussian locations at the edge of a region of interest that grows as individual Gaussians converge to crystal locations. The algorithm was tested with flood image data collected from 16 detector modules, each consisting of a 409 crystal dual-layer offset LYSO crystal array readout by a 32 pixel SiPM array. For these detector flood images, depending on user defined input parameters, the algorithm runtime ranged between 17.5-82.5 s per detector on a single core of an Intel i7 processor. The method maintained an accuracy above 99.8% across all tests, with the majority of errors being localized to error prone corner regions. This method can be easily extended for use with other detector types through adjustment of the initial

  9. An algorithm for automatic crystal identification in pixelated scintillation detectors using thin plate splines and Gaussian mixture models

    International Nuclear Information System (INIS)

    Schellenberg, Graham; Goertzen, Andrew L; Stortz, Greg

    2016-01-01

    A typical positron emission tomography detector is comprised of a scintillator crystal array coupled to a photodetector array or other position sensitive detector. Such detectors using light sharing to read out crystal elements require the creation of a crystal lookup table (CLUT) that maps the detector response to the crystal of interaction based on the x–y position of the event calculated through Anger-type logic. It is vital for system performance that these CLUTs be accurate so that the location of events can be accurately identified and so that crystal-specific corrections, such as energy windowing or time alignment, can be applied. While using manual segmentation of the flood image to create the CLUT is a simple and reliable approach, it is both tedious and time consuming for systems with large numbers of crystal elements. In this work we describe the development of an automated algorithm for CLUT generation that uses a Gaussian mixture model paired with thin plate splines (TPS) to iteratively fit a crystal layout template that includes the crystal numbering pattern. Starting from a region of stability, Gaussians are individually fit to data corresponding to crystal locations while simultaneously updating a TPS for predicting future Gaussian locations at the edge of a region of interest that grows as individual Gaussians converge to crystal locations. The algorithm was tested with flood image data collected from 16 detector modules, each consisting of a 409 crystal dual-layer offset LYSO crystal array readout by a 32 pixel SiPM array. For these detector flood images, depending on user defined input parameters, the algorithm runtime ranged between 17.5–82.5 s per detector on a single core of an Intel i7 processor. The method maintained an accuracy above 99.8% across all tests, with the majority of errors being localized to error prone corner regions. This method can be easily extended for use with other detector types through adjustment of the initial

  10. An algorithm for automatic crystal identification in pixelated scintillation detectors using thin plate splines and Gaussian mixture models

    Science.gov (United States)

    Schellenberg, Graham; Stortz, Greg; Goertzen, Andrew L.

    2016-02-01

    A typical positron emission tomography detector is comprised of a scintillator crystal array coupled to a photodetector array or other position sensitive detector. Such detectors using light sharing to read out crystal elements require the creation of a crystal lookup table (CLUT) that maps the detector response to the crystal of interaction based on the x-y position of the event calculated through Anger-type logic. It is vital for system performance that these CLUTs be accurate so that the location of events can be accurately identified and so that crystal-specific corrections, such as energy windowing or time alignment, can be applied. While using manual segmentation of the flood image to create the CLUT is a simple and reliable approach, it is both tedious and time consuming for systems with large numbers of crystal elements. In this work we describe the development of an automated algorithm for CLUT generation that uses a Gaussian mixture model paired with thin plate splines (TPS) to iteratively fit a crystal layout template that includes the crystal numbering pattern. Starting from a region of stability, Gaussians are individually fit to data corresponding to crystal locations while simultaneously updating a TPS for predicting future Gaussian locations at the edge of a region of interest that grows as individual Gaussians converge to crystal locations. The algorithm was tested with flood image data collected from 16 detector modules, each consisting of a 409 crystal dual-layer offset LYSO crystal array readout by a 32 pixel SiPM array. For these detector flood images, depending on user defined input parameters, the algorithm runtime ranged between 17.5-82.5 s per detector on a single core of an Intel i7 processor. The method maintained an accuracy above 99.8% across all tests, with the majority of errors being localized to error prone corner regions. This method can be easily extended for use with other detector types through adjustment of the initial

  11. Development of 10×10 Matrix-anode MCP-PMT

    Science.gov (United States)

    Yang, Jie; Li, Yongbin; Xu, Pengxiao; Zhao, Wenjin

    2018-02-01

    10×10 matrix-anode is developed by high-temperature co-fired ceramics (HTCC) technology. Based on the new matrix-anode, a new kind of photon counting imaging detector - 10×10 matrix-anode MCP-PMT is developed, and its performance parameters are tested. HTCC technology is suitable for the MCP-PMT's air impermeability and its baking process. Its response uniformity is better than the metal-ceramic or metal-glass sealing anode, and it is also a promising method to realize a higher density matrix-anode.

  12. Calibration of a Thomson parabola ion spectrometer and Fujifilm imaging plate detectors for protons, deuterons, and alpha particles.

    Science.gov (United States)

    Freeman, C G; Fiksel, G; Stoeckl, C; Sinenian, N; Canfield, M J; Graeper, G B; Lombardo, A T; Stillman, C R; Padalino, S J; Mileham, C; Sangster, T C; Frenje, J A

    2011-07-01

    A Thomson parabola ion spectrometer has been designed for use at the Multiterawatt (MTW) laser facility at the Laboratory for Laser Energetics (LLE) at the University of Rochester. This device uses parallel electric and magnetic fields to deflect particles of a given mass-to-charge ratio onto parabolic curves on the detector plane. Once calibrated, the position of the ions on the detector plane can be used to determine the particle energy. The position dispersion of both the electric and magnetic fields of the Thomson parabola was measured using monoenergetic proton and alpha particle beams from the SUNY Geneseo 1.7 MV tandem Pelletron accelerator. The sensitivity of Fujifilm BAS-TR imaging plates, used as a detector in the Thomson parabola, was also measured as a function of the incident particle energy over the range from 0.6 MeV to 3.4 MeV for protons and deuterons and from 0.9 MeV to 5.4 MeV for alpha particles. The device was used to measure the energy spectrum of laser-produced protons at MTW.

  13. Calibration of a Thomson parabola ion spectrometer and Fujifilm imaging plate detectors for protons, deuterons, and alpha particles

    Energy Technology Data Exchange (ETDEWEB)

    Freeman, C. G.; Canfield, M. J.; Graeper, G. B.; Lombardo, A. T.; Stillman, C. R.; Padalino, S. J. [Physics Department, SUNY Geneseo, Geneseo, New York 14454 (United States); Fiksel, G.; Stoeckl, C.; Mileham, C.; Sangster, T. C. [Laboratory for Laser Energetics, University of Rochester, Rochester, New York 14623 (United States); Sinenian, N.; Frenje, J. A. [Plasma Science and Fusion Center, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 (United States)

    2011-07-15

    A Thomson parabola ion spectrometer has been designed for use at the Multiterawatt (MTW) laser facility at the Laboratory for Laser Energetics (LLE) at University of Rochester. This device uses parallel electric and magnetic fields to deflect particles of a given mass-to-charge ratio onto parabolic curves on the detector plane. Once calibrated, the position of the ions on the detector plane can be used to determine the particle energy. The position dispersion of both the electric and magnetic fields of the Thomson parabola was measured using monoenergetic proton and alpha particle beams from the SUNY Geneseo 1.7 MV tandem Pelletron accelerator. The sensitivity of Fujifilm BAS-TR imaging plates, used as a detector in the Thomson parabola, was also measured as a function of the incident particle energy over the range from 0.6 MeV to 3.4 MeV for protons and deuterons and from 0.9 MeV to 5.4 MeV for alpha particles. The device was used to measure the energy spectrum of laser-produced protons at MTW.

  14. Evaluation of dose distributions in gamma chamber using glass plate detector

    Directory of Open Access Journals (Sweden)

    Narayan Pradeep

    2008-01-01

    Full Text Available A commercial glass plate of thickness 1.75 mm has been utilized for evaluation of dose distributions inside the irradiation volume of gamma chamber using optical densitometry technique. The glass plate showed linear response in the dose range 0.10 Kilo Gray (kGy to 10 kGy of cobalt-60 gamma radiation with optical sensitivity 0.04 Optical Density (OD /kGy. The change in the optical density at each identified spatial dose matrix on the glass plate in relation to the position in the irradiation volume has been presented as dose distributions inside the gamma chamber. The optical density changes have been graphically plotted in the form of surface diagram of color washes for different percentage dose rate levels as isodose distributions in gamma chamber. The variation in dose distribution inside the gamma chamber unit, GC 900, BRIT India make, using this technique has been observed within ± 15%. This technique can be used for routine quality assurances and dose distribution validation of any gamma chamber during commissioning and source replacement. The application of commercial glass plate for dose mapping in gamma chambers has been found very promising due to its wider dose linearity, quick measurement, and lesser expertise requirement in application of the technique.

  15. Calorimeter detector consisting of a KMgF3 scintillator and parallel-plate avalanche chamber

    International Nuclear Information System (INIS)

    Buzulutskov, A.F.; Turchanovich, L.K.; Vasil'chenko, V.G.

    1989-01-01

    Scintillations of a KMgF 3 crystal have been detected in the parallel-plate avalanche chamber with a TEA gaseous photocathode, the scintillation signal is shown to be much higher than the direct ionization one. The characteristic properties of the calorimeters on the basis of such structure with electrical and optical readout are discussed. 10 refs.; 4 figs

  16. Development of the RAIDS extreme ultraviolet wedge and strip detector. [Remote Atmospheric and Ionospheric Detector System

    Science.gov (United States)

    Kayser, D. C.; Chater, W. T.; Christensen, A. B.; Howey, C. K.; Pranke, J. B.

    1988-01-01

    In the next few years the Remote Atmospheric and Ionospheric Detector System (RAIDS) package will be flown on a Tiros spacecraft. The EUV spectrometer experiment contains a position-sensitive detector based on wedge and strip anode technology. A detector design has been implemented in brazed alumina and kovar to provide a rugged bakeable housing and anode. A stack of three 80:1 microchannel plates is operated at 3500-4100 V. to achieve a gain of about 10 to the 7th. The top MCP is to be coated with MgF for increased quantum efficiency in the range of 50-115 nm. A summary of fabrication techniques and detector performance characteristics is presented.

  17. Connection of leak detectors for duplex tube plates of modular steam generator

    International Nuclear Information System (INIS)

    Banovec, J.; Konarik, M.; Vytopil, O.

    1985-01-01

    The sensors are connected to common line and column conductors. This connection significantly reduces the number of evaluation points and thus also the required number of evaluation unit channels. The reliability of the instrument is increased by each sensor being connected to two separate group conductors. Even upon failure of one of the conductors, the group of tube plates can be identified where a leak occurred. (J.B.)

  18. Operation of Resistive Plate Chamber Detectors with a New Environmentally Friendly Freon

    CERN Document Server

    Lewis, Helen Elizabeth

    2014-01-01

    RPC particle gas detectors at CERN provide a vital element to the physics experiments carried out on the LHC. While their current operation and working gas mixtures are successful, environ- mental and economic factors force a revision of the mixture, specifically the eventual replacement of the current Freon gas R134-a with a newer, less environmentally harmful formulation, namely R1234-yf. The methods and results presented here outline the detector response to the introduction of the new Freon and its behavior under various mixtures. The electronegativity and hence impact on RPC parameters was investigated. It was found that the new Freon gas is indeed electroneg- ative, and suppresses the RPC signal. The mixture was modified to include Argon to increase ionization, and the final results of the operation of the RPC were satisfactory. Further work to refine the mixture for future implementation is necessary.

  19. Development of hybrid track detector using CR39 and photographic plate

    International Nuclear Information System (INIS)

    Kuge, K.; Endo, Y.; Hayashi, K.; Iwakiri, S.; Hasegawa, A.; Yasuda, N.; Kumagai, H.

    2005-01-01

    To improve the hybrid track detector using both CR39 and silver halide photography the gold deposition development technique was applied to this. Nuclear tracks composed of gold clusters were obtained. This method has several advantages; 1. no filament formation, 2. easy control of the cluster size owing to the independence of the size of silver halide grain, 3. easy treatment of the waste solution of developer. (author)

  20. Study of the electric field inside microchannel plate multipliers

    International Nuclear Information System (INIS)

    Gatti, E.; Oba, K.; Rehak, P.

    1982-01-01

    Electric field inside high gain microchannel plate multipliers was studied. The calculations were based directly on the solution of the Maxwell equations applied to the microchannel plate (MCP) rather than on the conventional lumped RC model. The results are important to explain the performance of MCP's, (1) under a pulsed bias tension and, (2) at high rate conditions. The results were tested experimentally and a new method of MCP operation free from the positive ion feedback was demonstrated

  1. Characterizations of MCP performance in the hard x-ray range (6–25 keV)

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Ming, E-mail: minwu@sandia.gov; Rochau, Greg [Sandia National Laboratory, Albuquerque, New Mexico 87185 (United States); Moy, Ken [Special Technology Laboratories, NSTec, Santa Barbara, California 93111-2335 (United States); Kruschwitz, Craig [National Security Technologies, LLC, Los Alamos Operations, Los Alamos, New Mexico 87544 (United States)

    2014-11-15

    MCP detector performance at hard x-ray energies from 6 to 25 keV was recently investigated using NSLS beamline X15A at BNL. Measurements were made with an NSTec Gen-II (H-CA-65) framing camera, based on a Photonis MCP with ∼10 μm in diameter pores, ∼12 μm center-center spacing, an L/D ratio of 46, and a bias angle of 8°. The MCP characterizations were focused on (1) energy and angle dependent sensitivity, (2) energy and angle dependent spatial resolution, (3) energy dependent gain performance, and (4) energy dependent dynamic range. These measurement corroborated simulation results using a Monte Carlo model that included hard x-ray interactions and the subsequent electron cascade in the MCP.

  2. Position-sensitive detector system OBI for High Resolution X-Ray Powder Diffraction using on-site readable image plates

    International Nuclear Information System (INIS)

    Knapp, M.; Joco, V.; Baehtz, C.; Brecht, H.H.; Berghaeuser, A.; Ehrenberg, H.; Seggern, H. von; Fuess, H.

    2004-01-01

    A one-dimensional detector system has been developed using image plates. The detector is working in transmission mode or Debye-Scherrer geometry and is on-site readable which reduces the effort for calibration. It covers a wide angular range up to 110 deg. and shows narrow reflection half-widths depending on the capillary diameter. The acquisition time is in the range of minutes and the data quality allows for reliable Rietveld refinement of complicated structures, even in multi-phase samples. The detector opens a wide field of new applications in kinetics and temperature resolved measurements

  3. Combined effects of 1-methyl cyclopropene (1-MCP) and modified ...

    African Journals Online (AJOL)

    1-MCP-treated fruits delayed two different harvest maturity, persimmon fruits flesh firmness, and combination of 1-MCP with MAPA and MAPB reduced the ethylene production rate during storage. Treatment of 1-MCP improved storability of persimmon fruits more effectively than MAP storage. However, the results indicated ...

  4. Gaining efficiency and resolution in soft X-ray emission spectrometers thanks to directly illuminated CCD detectors

    International Nuclear Information System (INIS)

    Dinardo, M.E.; Piazzalunga, A.; Braicovich, L.; Bisogni, V.; Dallera, C.; Giarda, K.; Marcon, M.; Tagliaferri, A.; Ghiringhelli, G.

    2007-01-01

    The back-illuminated charge coupled devices (CCD) are suitable for soft X-ray photon detection. Their nominal performances suggest that they can boost both efficiency and resolving power of X-ray spectrometers based on diffraction gratings and two-dimensional position sensitive detectors. We tested the performances of two commercially available CCDs, intended to replace a more traditional microchannel plate (MCP) detector. Our tests show that the devices have excellent performances in terms of dark current, response linearity, detection efficiency and spatial resolution. We observed that the CCDs have better efficiency (more than 10 times) and better resolution (∼3 times) than the MCP. Moreover we found an intrinsic limit for the spatial resolution, which is almost independent of the detector pixel size and is estimated around 25 μm

  5. Microchannel plate photodetectors

    International Nuclear Information System (INIS)

    Majka, R.

    1977-01-01

    A review is given the status of development work on photodetectors using microchannel plates (MCP) as the electron gain element. Projections are made and opinions are presented on what might be available in the next few years. Several uses for these devices at ISABELLE are mentioned

  6. Design, construction and setting of a parallel plate avalanche detector with coordinate read-out

    International Nuclear Information System (INIS)

    Guillermet, C.

    1980-01-01

    This detector planned for heavy ion experiments has the following dimensions: 150x210 mm 2 . Each coordinate of the trajectory is obtained from a plane of read-out wires located half-way between the two electrodes of each gap. Position read-out is made by the delay line method. Interpolating properties cancel out the effects of quantization due to the wires. Two gaps sharing a common electrode, with their wire-planes at 90 0 , furnish the two coordinates. The common electrode (Anode) delivers a fast signal on each ion crossing. Formation of signals on the anode with their distortion by the associated circuit was calculated. Formation of signals on the wires and their distortion into the delay lines was also determined. This allowed to evaluate the influence of the various parameters leading to an optimum time and space resolution. With 252 Cf fission products, 500 ps and 0.6 mm were so obtained. Differential linearity is better than 75 μm. Pulse height analysis of the anode signals makes discrimination between lightly and heavily ionizing ions possible [fr

  7. Assembly and Characterization of Resistive Plate Chambers in India for the CMS Detector

    CERN Document Server

    AUTHOR|(CDS)2084269

    2016-01-01

    The Compact Muon Solenoid (CMS) experiment is a general purpose detector being operated at Large Hadron Collider (LHC) facility at CERN. The RE4 upgrade project was envisaged to improve the Level-1 trigger efficiency in the forward region, when LHC would run at its full designed energy and luminosity after the first Long Shutdown (LS-1, 2013-2014). About 200 RPCs were built for the upgrade at three assembly sites in India, CERN and Ghent. India contributed to 50, RE4/2 RPCs along with 200 Cu-cooling units for the entire upgrade for which the assembly and characterization of RPCs was carried out jointly by Nuclear Physics Division-BARC and Panjab University-Chandigarh. The gas-gaps after their arrival from KODEL, South Korea, underwent mechanical tests for leak and popped spacers, followed by electrical tests for long term monitoring of leakage currents. After the assembly, each RPC was evaluated for its efficiency, cluster size, noise and strip profiles. The Cu-cooling units build at BARC were also tested acc...

  8. MCP characterization at the Cu and Mo Kα x-ray energies

    International Nuclear Information System (INIS)

    Walsh, P.J.; Evans, S.; Schappert, G.T.; Kyrala, G.A.

    1998-03-01

    The authors are investigating the usefulness of microchannel plate (MCP) intensifiers for imaging x-rays at high photon energies, specifically by using filtered X-rays from an electron bombardment source to generate the K α lines of Cu at 8.04 KeV and Mo at 17.5 KeV. These high energy lines are used to measure the resolution of an MCP based intensifier produced at Los Alamos National Laboratory. They have investigated the spot size of a fielded MCP intensifier by observing, on film, the result of single photon excitation of microchannels. Measurement of the spot size was done with visible light microscopy. They report initial results of the spot size distribution in the stripline direction. They have also begun a measurement of the azimuthal anisotropy in the spatial resolution, accentuated at these energies by the inclination of the axis of the MCP channels. They concentrate on an actual ''fielded instrument'' resolution, rather than ideal, for the purpose of analyzing image data captured at the NOVA Laser Facility

  9. Some studies on the pulse-height loss due to capacitive decay in the detector-circuit of parallel plate ionization chambers

    International Nuclear Information System (INIS)

    Sharma, S.L.; Anil Kumar, G.; Choudhury, R.K.

    2006-01-01

    Pulse-type ionization chambers are invariably operated in the electron-sensitive mode where the capacitive decay in the detector-circuit during the electron collection produces loss in the pulse-height. In order to understand and appreciate the effect of this capacitive decay on the detector response, we have carried out Monte Carlo simulations of the response of two-electrode parallel plate ionization chambers with and without the capacitive decay keeping shaping time so large that the ballistic deficit is negligibly small. These simulations have been carried out incorporating the physical processes, namely, emission of charged particles from a point radioactive source, the generation of charge carriers in the active volume, separation and acceleration of the charge carriers, transport of the charge carriers, induction of charges on the electrodes, pulse processing by preamplifier-amplifier network, etc. These simulations have shown that the concerned capacitive decay produces appreciable loss in the pulse-height, if the detector-circuit time constant is of the order of maximum electron collection time. We have also carried out measurements on the pulse-height loss due to the capacitive decay in the detector-circuit during the electron collection for a two-electrode parallel plate ionization chamber. The experimental data on the pulse-height loss match reasonably well with the theoretical predictions

  10. Studies on multigap resistive plate chamber prototypes for the new NeuLAND detector at the R3B experiment at FAIR

    Energy Technology Data Exchange (ETDEWEB)

    Elvers, Michael; Endres, Janis; Zilges, Andreas [IKP, Universitaet Koeln (Germany); Aumann, Tom; Boretzky, Konstanze; Hehner, Joerg; Heil, Michael; Prokopowicz, Wawrczek; Reifarth, Rene; Schrieder, Gerhard [Gesellschaft fuer Schwerionenforschung (GSI), Darmstadt (Germany); Bemmerer, Daniel; Stach, Daniel; Wagner, Andreas; Yakorev, Dmitry [Forschungszentrum Dresden-Rossendorf (FZD), Dresden (Germany); Kratz, Jens Volker; Rossi, Dominic [Johannes-Gutenberg-Universitaet, Mainz (Germany)

    2009-07-01

    The NeuLAND detector is part of the R3B experiment at FAIR and will detect neutrons between 0.2 and 1 GeV. The high energy neutrons are converted to charged particles, mainly protons, which are detected by Multigap Resistive Plate Chambers (MRPC). For the detector, a time resolution of {sigma}{sub t} < 100 ps and a position resolution of {sigma}{sub x,y,z} {approx}1 cm is required for given flight paths in the range from 10 to 35 m. An active area of 2 x 2 m{sup 2} of the neutron detector at a distance of 12.5 m to the target will match the angular acceptance of {+-}80 mrad for the neutrons defined by the gap of the superconducting dipole magnet. The salient features of the prototypes are described, as well as electrical measurements and studies with cosmic rays.

  11. Characterisation of deuterium spectra from laser driven multi-species sources by employing differentially filtered image plate detectors in Thomson spectrometers

    International Nuclear Information System (INIS)

    Alejo, A.; Kar, S.; Ahmed, H.; Doria, D.; Green, A.; Jung, D.; Lewis, C. L. S.; Nersisyan, G.; Krygier, A. G.; Freeman, R. R.; Clarke, R.; Green, J. S.; Notley, M.; Fernandez, J.; Fuchs, J.; Kleinschmidt, A.; Roth, M.; Morrison, J. T.; Najmudin, Z.; Nakamura, H.

    2014-01-01

    A novel method for characterising the full spectrum of deuteron ions emitted by laser driven multi-species ion sources is discussed. The procedure is based on using differential filtering over the detector of a Thompson parabola ion spectrometer, which enables discrimination of deuterium ions from heavier ion species with the same charge-to-mass ratio (such as C 6+ , O 8+ , etc.). Commonly used Fuji Image plates were used as detectors in the spectrometer, whose absolute response to deuterium ions over a wide range of energies was calibrated by using slotted CR-39 nuclear track detectors. A typical deuterium ion spectrum diagnosed in a recent experimental campaign is presented, which was produced from a thin deuterated plastic foil target irradiated by a high power laser

  12. Characterisation of deuterium spectra from laser driven multi-species sources by employing differentially filtered image plate detectors in Thomson spectrometers

    Science.gov (United States)

    Alejo, A.; Kar, S.; Ahmed, H.; Krygier, A. G.; Doria, D.; Clarke, R.; Fernandez, J.; Freeman, R. R.; Fuchs, J.; Green, A.; Green, J. S.; Jung, D.; Kleinschmidt, A.; Lewis, C. L. S.; Morrison, J. T.; Najmudin, Z.; Nakamura, H.; Nersisyan, G.; Norreys, P.; Notley, M.; Oliver, M.; Roth, M.; Ruiz, J. A.; Vassura, L.; Zepf, M.; Borghesi, M.

    2014-09-01

    A novel method for characterising the full spectrum of deuteron ions emitted by laser driven multi-species ion sources is discussed. The procedure is based on using differential filtering over the detector of a Thompson parabola ion spectrometer, which enables discrimination of deuterium ions from heavier ion species with the same charge-to-mass ratio (such as C6 +, O8 +, etc.). Commonly used Fuji Image plates were used as detectors in the spectrometer, whose absolute response to deuterium ions over a wide range of energies was calibrated by using slotted CR-39 nuclear track detectors. A typical deuterium ion spectrum diagnosed in a recent experimental campaign is presented, which was produced from a thin deuterated plastic foil target irradiated by a high power laser.

  13. Characterisation of deuterium spectra from laser driven multi-species sources by employing differentially filtered image plate detectors in Thomson spectrometers

    Energy Technology Data Exchange (ETDEWEB)

    Alejo, A.; Kar, S., E-mail: s.kar@qub.ac.uk; Ahmed, H.; Doria, D.; Green, A.; Jung, D.; Lewis, C. L. S.; Nersisyan, G. [Centre for Plasma Physics, School of Mathematics and Physics, Queen' s University Belfast, Belfast BT7 1NN (United Kingdom); Krygier, A. G.; Freeman, R. R. [Department of Physics, The Ohio State University, Columbus, Ohio 43210 (United States); Clarke, R.; Green, J. S.; Notley, M. [Central Laser Facility, Rutherford Appleton Laboratory, Didcot, Oxfordshire OX11 0QX (United Kingdom); Fernandez, J. [Central Laser Facility, Rutherford Appleton Laboratory, Didcot, Oxfordshire OX11 0QX (United Kingdom); Instituto de Fusión Nuclear, Universidad Politécnica de Madrid, 28006 Madrid (Spain); Fuchs, J. [LULI, École Polytechnique, CNRS, CEA, UPMC, 91128 Palaiseau (France); Kleinschmidt, A.; Roth, M. [Institut für Kernphysik, Technische Universität Darmstadt, Schloßgartenstrasse 9, D-64289 Darmstadt (Germany); Morrison, J. T. [Propulsion Systems Directorate, Air Force Research Lab, Wright Patterson Air Force Base, Ohio 45433 (United States); Najmudin, Z.; Nakamura, H. [Blackett Laboratory, Department of Physics, Imperial College, London SW7 2AZ (United Kingdom); and others

    2014-09-15

    A novel method for characterising the full spectrum of deuteron ions emitted by laser driven multi-species ion sources is discussed. The procedure is based on using differential filtering over the detector of a Thompson parabola ion spectrometer, which enables discrimination of deuterium ions from heavier ion species with the same charge-to-mass ratio (such as C{sup 6+}, O{sup 8+}, etc.). Commonly used Fuji Image plates were used as detectors in the spectrometer, whose absolute response to deuterium ions over a wide range of energies was calibrated by using slotted CR-39 nuclear track detectors. A typical deuterium ion spectrum diagnosed in a recent experimental campaign is presented, which was produced from a thin deuterated plastic foil target irradiated by a high power laser.

  14. Silicon-micromachined microchannel plates

    CERN Document Server

    Beetz, C P; Steinbeck, J; Lemieux, B; Winn, D R

    2000-01-01

    Microchannel plates (MCP) fabricated from standard silicon wafer substrates using a novel silicon micromachining process, together with standard silicon photolithographic process steps, are described. The resulting SiMCP microchannels have dimensions of approx 0.5 to approx 25 mu m, with aspect ratios up to 300, and have the dimensional precision and absence of interstitial defects characteristic of photolithographic processing, compatible with positional matching to silicon electronics readouts. The open channel areal fraction and detection efficiency may exceed 90% on plates up to 300 mm in diameter. The resulting silicon substrates can be converted entirely to amorphous quartz (qMCP). The strip resistance and secondary emission are developed by controlled depositions of thin films, at temperatures up to 1200 deg. C, also compatible with high-temperature brazing, and can be essentially hydrogen, water and radionuclide-free. Novel secondary emitters and cesiated photocathodes can be high-temperature deposite...

  15. Systemic MCP1/CCR2 blockade and leukocyte specific MCP1/CCR2 inhibition affect aortic aneurysm formation differently

    NARCIS (Netherlands)

    de Waard, Vivian; Bot, Ilze; de Jager, Saskia C. A.; Talib, Sara; Egashira, Kensuke; de Vries, Margreet R.; Quax, Paul H. A.; Biessen, Erik A. L.; van Berkel, Theo J. C.

    2010-01-01

    Objective: CCR2, the receptor for monocyte chemoattractant protein 1 (MCP1), is involved in atherosclerosis and abdominal aortic aneurysms (AAAs). Here, we explored the potential beneficial blockade of the MCP1/CCR2 pathway. Methods: We applied an AAA model in aging apolipoprotein E deficient mice

  16. Comparative study of main dosimetric characteristics between the GR-200A and MCP-N LiF (Mg, Cu, P) TLD chips

    International Nuclear Information System (INIS)

    Shen Wenxiu; Tang Kaiyong; Wang Shoushan; Cai Gangang; Zhu Hongying; Lu Min

    1999-01-01

    GR-200A and MCP-N are the same kind of LiF(Mg, Cu, P) chip detectors. The main dosimetric characteristics of two LiF (Mg, Cu, P) chip TLDs (GR-200A made in Solid Dosimetric Detector and Method Laboratory, Beijing, and MCP-N made in Poland) are compared, including glow curve structure, TL sensitivity, anti-moisture, reproducibility, background, detection threshold and photosensitivity. Sensitivity of GR-200a is 1.6 times as much as that of MCP-N. The sensitivity of GR-200A is stable after being used for six times, but the sensitivity of MCP-N dropped 2.8%, and its colour turned from white into light brown. The sensitivity and colour of GR-200A did not vary after being stored for 25 days at 98% RH, by comparison the sensitivity of MCP-N dropped 14%, and its colour turned into light brown. It was found that the GR-200A TLD is superior to the MCP-N TLD in above-mentioned characteristics

  17. Multiple-photon disambiguation on stripline-anode Micro-Channel Plates

    Energy Technology Data Exchange (ETDEWEB)

    Jocher, Glenn R., E-mail: glenn.jocher@ultralytics.com [Ultralytics LLC, Arlington, VA 22203 (United States); Wetstein, Matthew J., E-mail: mwetstein@uchicago.edu [Iowa State University, Department of Physics and Astronomy, 12 Physics Hall, Ames, IA 50011 (United States); Adams, Bernhard, E-mail: badams@incomusa.com [Incom, Inc., 294 Southbridge Road, Charlton, MA 01507 (United States); Nishimura, Kurtis, E-mail: kurtis.nishimura@ultralytics.com [Ultralytics LLC, Arlington, VA 22203 (United States); Usman, Shawn M., E-mail: shawn.usman@nga.mil [Research Directorate, National Geospatial-Intelligence Agency, 7500 GEOINT Dr., Springfield, VA 22150 (United States); Department of Geography and Geoinformation Science, George Mason University, Fairfax, VA 22030 (United States)

    2016-06-21

    Large-Area Picosecond Photo-Detectors (LAPPDs) show great potential for expanding the performance envelope of Micro-Channel Plates (MCPs) to areas of up to 20×20 cm and larger. Such scaling introduces new challenges, including how to meet the electronics readout burden of ever larger area MCPs. One solution is to replace the traditional grid anode used for readout with a microwave stripline anode, thus allowing the channel count to scale with MCP width rather than area. However, stripline anodes introduce new issues not commonly dealt with in grid-anodes, especially as their length increases. One of these issues is the near simultaneous arrival of multiple photons on the detector, creating possible confusion about how to reconstruct their arrival times and positions. We propose a maximum a posteriori solution to the problem and verify its performance in simulated scintillator and water-Cherenkov detectors.

  18. Transmission-Line Readout with Good Time and Space Resolutions for Planacon MCP-PMTs

    CERN Document Server

    Tang, F; Byrum, K; Drake, G; Ertley, C; Frisch, H; Genat, J-F; May, E

    2008-01-01

    With commercially-available multi-anode microchannel plate photomultiplier tubes (MCP-PMT) and electronics, resolutions significantly better than 10 psec have been achieved in small systems with a few readout channels[1,2]. For large-scale time-of-flight systems used in particle physics, which may cover tens of square meters, a solution must be found with a manageable number of electronics channels and low total power consumption on the readout electronics without degrading the system timing resolution. We present here the design of a transmission-line readout for a Photonis Planacon MCP-PMT that has these characteristics. The tube, which is 5 cm square, is characterized by signal pulse rise times in the order of 200 psec and transit time spreads (TTS) in the order of 25 psec[1, 2]. The model 85011-011 MCP has 1024 anode pads laid out in an array of 32 by 32 on the back of the tube. The proposed readout is implemented on a Rogers 4350B printed circuit board with 32 parallel 50-ohm transmission lines on 1.6 mm...

  19. Optimization design of a 20-in. elliptical MCP-PMT

    International Nuclear Information System (INIS)

    Chen, Ping; Tian, Jinshou; Wei, Yonglin; Liu, Hulin; Sai, Xiaofeng; He, Jianping; Chen, Lin; Wang, Xing; Lu, Yu

    2017-01-01

    This paper describes the simulation work for optimizing the newly developed 20-in. elliptical MCP-PMT by enlarging the outside diameters of the two focusing electrodes and the open area of the glass bulb. Effects of biasing voltages applied to the two focusing electrodes and the MCP input facet are studied. With the new design of the 20 in. MCP-PMT, the transit time spread of the prototype can be less than 3 ns and the collection efficiency is as much as the present prototype.

  20. High rate resistive plate chambers: An inexpensive, fast, large area detector of energetic charged particles for accelerator and non-accelerator applications

    International Nuclear Information System (INIS)

    Wuest, C.R.; Ables, E.; Bionta, R.M.; Clamp, O.; Haro, M.; Mauger, G.J.; Miller, K.; Olson, H.; Ramsey, P.

    1993-05-01

    Resistive Plate Chambers, or RPCs, have been used until recently as large detectors of cosmic ray muons. They are now finding use as fast large-area trigger and muon detection systems for different high energy physics detectors such the L3 Detector at LEP and future detectors to be built at the Superconducting Super Collider (SSC) and at the Large Hadron Collider (LHC) at CERN. RPC systems at these accelerators must operate with high efficiency, providing nanosecond timing resolution in particle fluences up to a few tens of kHz/cm 2 -- with thousands of square meters of active area. RPCs are simple and cheap to construct. The authors report here recent work on RPCs using new materials that exhibit a combination of desirable RPC features such as low bulk resistivity, high dielectric strength, low mass, and low cost. These new materials were originally developed for use in electronics assembly areas and other applications, where static electric charge buildup can damage sensitive electrical systems

  1. Effect of 1-methylcyclopropene (1- MCP) treatment on antioxidant ...

    African Journals Online (AJOL)

    ajl2

    2013-02-13

    Feb 13, 2013 ... of active oxygen-related metabolism of post-harvest Japanese apricot. The results ... a high content of vitamin C (ascorbic acid) and retarding the decrease ..... components analysis of the nfluence of 1-MCP and salicylic acid.

  2. Effects of Triptergium Glycosides on Expressions of MCP- 1 and ...

    African Journals Online (AJOL)

    the pathogenesis of diabetic nephropathy (DN), which is one of the chronic ..... the release of lysosomal enzymes and TGF, increase the ... important roles in the pathogenesis of this disease. Thus, MCP-1 and CTGF are potential targets for ...

  3. CCL2/MCP-1 modulation of microglial activation and proliferation

    Directory of Open Access Journals (Sweden)

    Garcia-Bueno Borja

    2011-07-01

    Full Text Available Abstract Background Monocyte chemoattractant protein (CCL2/MCP-1 is a chemokine that attracts cells involved in the immune/inflammatory response. As microglia are one of the main cell types sustaining inflammation in brain, we proposed here to analyze the direct effects of MCP-1 on cultured primary microglia. Methods Primary microglia and neuronal cultures were obtained from neonatal and embryonic Wistar rats, respectively. Microglia were incubated with different concentrations of recombinant MCP-1 and LPS. Cell proliferation was quantified by measuring incorporation of bromodeoxyuridine (BrdU. Nitrite accumulation was measured using the Griess assay. The expression and synthesis of different proteins was measured by RT-PCR and ELISA. Cell death was quantified by measuring release of LDH into the culture medium. Results MCP-1 treatment (50 ng/ml, 24 h did not induce morphological changes in microglial cultures. Protein and mRNA levels of different cytokines were measured, showing that MCP-1 was not able to induce proinflammatory cytokines (IL-1β, IL6, MIP-1α, either by itself or in combination with LPS. A similar lack of effect was observed when measuring inducible nitric oxide synthase (NOS2 expression or accumulation of nitrites in the culture media as a different indicator of microglial activation. MCP-1 was also unable to alter the expression of different trophic factors that were reduced by LPS treatment. In order to explore the possible release of other products by microglia and their potential neurotoxicity, neurons were co-cultured with microglia: no death of neurons could be detected when treated with MCP-1. However, the presence of MCP-1 induced proliferation of microglia, an effect opposite to that observed with LPS. Conclusion These data indicate that, while causing migration and proliferation of microglia, MCP-1 does not appear to directly activate an inflammatory response in this cell type, and therefore, other factors may be

  4. The multigap resistive plate chamber as time-of-flight detector for the STAR experiment at RHIC

    International Nuclear Information System (INIS)

    Lamas V, J.

    2002-01-01

    The multigap resistive plate chamber (MRPC) is a suitable candidate for the time-of-flight system for the STAR experiment at RHIC at the BNL. A time resolution of 50 ps with an efficiency of 98% has been measured with MRPCs composed of 6 gas gaps of 220 μm. Results obtained during the year 2000 are reported here

  5. A broad-application microchannel-plate detector system for advanced particle or photon detection tasks large area imaging, precise multi-hit timing information and high detection rate

    CERN Document Server

    Jagutzki, O; Mergel, V; Schmidt-Böcking, H; Spielberger, L; Spillmann, U; Ullmann-Pfleger, K

    2002-01-01

    New applications for single particle and photon detection in many fields require both large area imaging performance and precise time information on each detected particle. Moreover, a very high data acquisition rate is desirable for most applications and eventually the detection and imaging of more than one particle arriving within a microsecond is required. Commercial CCD systems lack the timing information whereas other electronic microchannel plate (MCP) read-out schemes usually suffer from a low acquisition rate and complicated and sometimes costly read-out electronics. We have designed and tested a complete imaging system consisting of an MCP position readout with helical wire delay-lines, single-unit amplifier box and PC-controlled time-to-digital converter (TDC) readout. The system is very flexible and can detect and analyse position and timing information at single particle rates beyond 1 MHz. Alternatively, multi-hit events can be collected and analysed at about 20 kHz rate. We discuss the advantage...

  6. Study on MCP-1 related to inflammation induced by biomaterials

    International Nuclear Information System (INIS)

    Ding Tingting; Sun Jiao; Zhang Ping

    2009-01-01

    The study of inflammation is important for understanding the reaction between biomaterials and the human body, in particular, the interaction between biomaterials and immune system. In the current study, rat macrophages were induced by multiple biomaterials with different biocompatibilities, including polyvinyl chloride (PVC) containing 8% of organic tin, a positive control material with cellular toxicity. Human umbilical vein endothelial cells (ECV-304), cultured with PRMI-1640, were detached from cells cultured with the supernatant of macrophages containing TNF-α and IL-1β because of stimulation by biomaterials. The cells were then treated with different biomaterials. Then both TNF-α and IL-1β in macrophages were detected by ELISA. Levels of monocyte chemoattractant protein-1 (MCP-1) were measured by RT-PCR. The results suggested that the expression of TNF-α and IL-1β was elevated by polytetrafluoroethylene (PTFE), polylactic-co-glycolic acid (PLGA) and American NPG alloy (p < 0.001). The level of MCP-1 cultured in supernatant of macrophages was higher than in PRMI-1640 with the same biomaterials. And the exposure to PTFE, PLGA and NPG resulted in the high expression of MCP-1 (p < 0.001) following cytokine stimulation. MCP-1 was also significantly expressed in β-tricalcium phosphate (β-TCP) and calcium phosphate cement samples (CPC) (p < 0.01). Thus, TNF-α, IL-1β and MCP-1 had played an important role in the immune reaction induced by biomaterials and there was a close relationship between the expression of cytokines and biomcompatibility of biomaterials. Furthermore, these data suggested that MCP-1 was regulated by TNF-α and IL-1β, and activated by both cytokines and biomaterials. The data further suggested that the expression of MCP-1 could be used as a marker to indicate the degree of immune reaction induced by biomaterials.

  7. Study of capillary tracking detectors with position-sensitive photomultiplier readout

    International Nuclear Information System (INIS)

    Cardini, A.; Cavasinni, V.; Di Girolamo, B.; Dolinsky, S.I.; Flaminio, V.; Golovkin, S.V.; Gorin, A.M.; Medvedkov, A.M.; Pyshev, A.I.; Tyukov, V.E.; Vasilchenko, V.G.; Zymin, K.V.

    1995-01-01

    Measurements have been carried out on light yield and attenuation length in glass capillaries filled with new liquid scintillators (LS) and compared with analogous measurements made on 0.5 mm diameter plastic fibres Kuraray SCSF-38 and 3HF. It is found that, at a distance of 1 m, the light output in the capillary filled with green LS based on 1-methylnaphthalene doped with a new dye 3M15 is greater by a factor of 2 to 3 than for plastic fibres. A tracking detector consisting of a capillary bundle read out by a 100 channel position-sensitive microchannel plate photomultiplier (2MCP-100) has been built and tested in the laboratory using a cosmic ray trigger. A comparison has been made between the performance of such a detector and that of a similar one, read out by a 96 channel Philips XP1724/A photomultiplier. It was found that a bundle made of 20μm diameter capillaries with a tapered end giving a magnification of 2.56, filled with the new IPN+3M15 liquid scintillator, read out by the 2MCP-100, provides a space resolution of σ=170μm, a two-track resolution of the same value and a hit density of n=1.9/mm for tracks crossing the detector at a distance of 20 cm from the photocathode. If the same detector is read out by the Philips XP1724/A, the space resolution becomes 200μm, the two-track resolution 600μm and the hit density n=1.7/mm. The worse performance in the latter case is caused by the larger crosstalk compared with that of the 2MCP-100 PSPM. The results indicate that a LS-filled capillary detector is a very promising device for fast fibre tracking. (orig.)

  8. Particle identification for a future EIC detector

    Science.gov (United States)

    Ilieva, Y.; Allison, L.; Barber, C.; Cao, T.; Del Dotto, A.; Gleason, C.; He, X.; Kalicy, G.; McKisson, J.; Nadel-Turonski, P.; Park, K.; Rapoport, J.; Schwarz, C.; Schwiening, J.; Wong, C. P.; Zhao, Zh.; Zorn, C.

    2018-03-01

    In its latest Long Range Plan for Nuclear Science Research in the U.S., the Nuclear Science Advisory Committee to the Department of Energy recommended that in regards to new nuclear-physics facilities, the construction of an Electron Ion Collider (EIC) be of the highest priority after the completion of the Facility for Rare Isotope Beams. In order to carry out key aspects of the scientific program of the EIC, the EIC central detector must be capable of hadron particle identification (PID) over a broad momentum range of up to 50 GeV/c. The goal of the EIC-PID consortium is to develop an integrated program for PID at EIC, which employs several different technologies for imaging Cherenkov detectors. Here we discuss the conceptual designs and the expected PID performance of two of these detectors, as well as the newest results of gain evaluation studies of photon sensors that are good candidates to read out these detectors. Development of a gas-aerogel dual-radiator Ring Imaging Cherenkov (dRICH) detector with outward focusing mirrors is being pursued for the hadron endcap. Simulations demonstrate that the dRICH can provide a continuous >= 3σ π /K/p separation from 2.5 GeV/c to 50 GeV/c. A modular aerogel Ring Imaging Cherenkov (mRICH) detector with a Fresnel lens as a focusing element is being pursued for the electron endcap. The design provides for hadron identification over a momentum range of 3 GeV/c-10 GeV/c. The working principle of the mRICH design has been proven in a beam test with a first prototype. The location of the sensor readout planes of the Cherenkov detectors in the magnetic field of the central-detector solenoid, which is expected to be within 1.5 T-3 T, makes is necessary to evaluate the limit of the acceptable performance of commercially available photosensors, such as microchannel-plate photomultipliers (MCP PMTs). Here we present the results of gain evaluation of multi-anode MCP PMTs with a pore size of 10 μm. Overall, our preliminary results

  9. Microchannel plate special nuclear materials sensor

    International Nuclear Information System (INIS)

    Feller, W.B.; White, P.L.; White, P.B.; Siegmund, O.H.W.; Martin, A.P.; Vallerga, J.V.

    2011-01-01

    Nova Scientific Inc., is developing for the Domestic Nuclear Detection Office (DNDO SBIR no. HSHQDC-08-C-00190), a solid-state, high-efficiency neutron detection alternative to 3 He gas tubes, using neutron-sensitive microchannel plates (MCPs) containing 10 B and/or Gd. This work directly supports DNDO development of technologies designed to detect and interdict nuclear weapons or illicit nuclear materials. Neutron-sensitized MCPs have been shown theoretically and more recently experimentally, to be capable of thermal neutron detection efficiencies equivalent to 3 He gas tubes. Although typical solid-state neutron detectors typically have an intrinsic gamma sensitivity orders of magnitude higher than that of 3 He gas detectors, we dramatically reduce gamma sensitivity by combining a novel electronic coincidence rejection scheme, employing a separate but enveloping gamma scintillator. This has already resulted in a measured gamma rejection ratio equal to a small 3 He tube, without in principle sacrificing neutron detection efficiency. Ongoing improvements to the MCP performance as well as the coincidence counting geometry will be described. Repeated testing and validation with a 252 Cf source has been underway throughout the Phase II SBIR program, with ongoing comparisons to a small commercial 3 He gas tube. Finally, further component improvements and efforts toward integration maturity are underway, with the goal of establishing functional prototypes for SNM field testing.

  10. A high-speed data-collection system for large-unit-cell crystals using an imaging plate as a detector

    International Nuclear Information System (INIS)

    Sato, Mamoru; Yamamoto, Masaki; Imada, Katsumi; Katsube, Yukiteru; Tanaka, Nobuo; Higashi, Tsuneyuki

    1992-01-01

    A high-speed data-collection system for large-unit-cell crystals is presented, using the Fuji Imaging Plate as an X-ray detector and a rotating-anode generator as the X-ray source. It is an automatic data-acquisition system that requires almost no manual intervention. The quality of data collected on the system is discussed. Merging R values ranged from 0.04 to 0.05. Compared with a four-circle diffractometer, data reproducibility was better, isomorphous/anomalous Patterson maps were almost identical in quality and data from a small-molecule crystal, cytidine, were of almost the same quality. Protein structures were refinable using the data measured on the system, the final crystallographic R value of the 2.2 A 3-isopropylmalate dehydrogenase structure being 0.185 and that of the 1.88 A Flammulina veltipes agglutinin structure being 0.199. (orig.)

  11. Characterization of trabecular bone plate-rod microarchitecture using multirow detector CT and the tensor scale: Algorithms, validation, and applications to pilot human studies

    Science.gov (United States)

    Saha, Punam K.; Liu, Yinxiao; Chen, Cheng; Jin, Dakai; Letuchy, Elena M.; Xu, Ziyue; Amelon, Ryan E.; Burns, Trudy L.; Torner, James C.; Levy, Steven M.; Calarge, Chadi A.

    2015-01-01

    Purpose: Osteoporosis is a common bone disease associated with increased risk of low-trauma fractures leading to substantial morbidity, mortality, and financial costs. Clinically, osteoporosis is defined by low bone mineral density (BMD); however, increasing evidence suggests that trabecular bone (TB) microarchitectural quality is an important determinant of bone strength and fracture risk. A tensor scale based algorithm for in vivo characterization of TB plate-rod microarchitecture at the distal tibia using multirow detector CT (MD-CT) imaging is presented and its performance and applications are examined. Methods: The tensor scale characterizes individual TB on the continuum between a perfect plate and a perfect rod and computes their orientation using optimal ellipsoidal representation of local structures. The accuracy of the method was evaluated using computer-generated phantom images at a resolution and signal-to-noise ratio achievable in vivo. The robustness of the method was examined in terms of stability across a wide range of voxel sizes, repeat scan reproducibility, and correlation between TB measures derived by imaging human ankle specimens under ex vivo and in vivo conditions. Finally, the application of the method was evaluated in pilot human studies involving healthy young-adult volunteers (age: 19 to 21 yr; 51 females and 46 males) and patients treated with selective serotonin reuptake inhibitors (SSRIs) (age: 19 to 21 yr; six males and six females). Results: An error of (3.2% ± 2.0%) (mean ± SD), computed as deviation from known measures of TB plate-width, was observed for computer-generated phantoms. An intraclass correlation coefficient of 0.95 was observed for tensor scale TB measures in repeat MD-CT scans where the measures were averaged over a small volume of interest of 1.05 mm diameter with limited smoothing effects. The method was found to be highly stable at different voxel sizes with an error of (2.29% ± 1.56%) at an in vivo voxel size

  12. MCP1 haplotypes associated with protection from pulmonary tuberculosis

    Directory of Open Access Journals (Sweden)

    Owusu-Dabo Ellis

    2011-04-01

    Full Text Available Abstract Background The monocyte chemoattractant protein 1 (MCP-1 is involved in the recruitment of lymphocytes and monocytes and their migration to sites of injury and cellular immune reactions. In a Ghanaian tuberculosis (TB case-control study group, associations of the MCP1 -362C and the MCP1 -2581G alleles with resistance to TB were recently described. The latter association was in contrast to genetic effects previously described in study groups originating from Mexico, Korea, Peru and Zambia. This inconsistency prompted us to further investigate the MCP1 gene in order to determine causal variants or haplotypes genetically and functionally. Results A 14 base-pair deletion in the first MCP1 intron, int1del554-567, was strongly associated with protection against pulmonary TB (OR = 0.84, CI 0.77-0.92, Pcorrected = 0.00098. Compared to the wildtype combination, a haplotype comprising the -2581G and -362C promoter variants and the intronic deletion conferred an even stronger protection than did the -362C variant alone (OR = 0.78, CI 0.69-0.87, Pnominal = 0.00002; adjusted Pglobal = 0.0028. In a luciferase reporter gene assay, a significant reduction of luciferase gene expression was observed in the two constructs carrying the MCP1 mutations -2581 A or G plus the combination -362C and int1del554-567 compared to the wildtype haplotype (P = 0.02 and P = 0.006. The associated variants, in particular the haplotypes composed of these latter variants, result in decreased MCP-1 expression and a decreased risk of pulmonary TB. Conclusions In addition to the results of the previous study of the Ghanaian TB case-control sample, we have now identified the haplotype combination -2581G/-362C/int1del554-567 that mediates considerably stronger protection than does the MCP1 -362C allele alone (OR = 0.78, CI 0.69-0.87 vs OR = 0.83, CI 0.76-0.91. Our findings in both the genetic analysis and the reporter gene study further indicate a largely negligible role of the

  13. Quality management of cut carnation 'Tempo' with 1- MCP

    African Journals Online (AJOL)

    STORAGESEVER

    2009-10-19

    Oct 19, 2009 ... carnation 'Tempo' which is an ethylene-sensitive flower, were evaluated. The effects of 1-MCP .... rolling of the petals. Water uptake rate (ml g-1 .... The studies of Chamani (2006) on Rosa 'First red' cut flowers revealed that ...

  14. Quality management of cut carnation 'Tempo' with 1- MCP | Abadi ...

    African Journals Online (AJOL)

    Quality management of cut carnation 'Tempo' with 1- MCP. ... African Journal of Biotechnology ... time durations (3, 6 and 9 h) on the vaselife, water uptake, loss of fresh weight and chlorophyll index of cut carnation 'Tempo' which is an ...

  15. Gain uniformity, linearity, saturation and depletion in gated microchannel-plate x-ray framing cameras

    International Nuclear Information System (INIS)

    Landen, O.L.; Bell, P.M.; Satariano, J.J.; Oertel, J.A.; Bradley, D.K.

    1994-01-01

    The pulsed characteristics of gated, stripline configuration microchannel-plate (MCP) detectors used in X-ray framing cameras deployed on laser plasma experiments worldwide are examined in greater detail. The detectors are calibrated using short (20 ps) and long (500 ps) pulse X-ray irradiation and 3--60 ps, deep UV (202 and 213 nm), spatially-smoothed laser irradiation. Two-dimensional unsaturated gain profiles show 5 in irradiation and fitted using a discrete dynode model. Finally, a pump-probe experiment quantifying for the first time long-suspected gain depletion by strong localized irradiation was performed. The mechanism for the extra voltage and hence gain degradation is shown to be associated with intense MCP irradiation in the presence of the voltage pulse, at a fluence at least an order of magnitude above that necessary for saturation. Results obtained for both constant pump area and constant pump fluence are presented. The data are well modeled by calculating the instantaneous electrical energy loss due to the intense charge extraction at the pump site and then recalculating the gain downstream at the probe site given the pump-dependent degradation in voltage amplitude

  16. A novel solution to the gated x-ray detector gain droop problem

    International Nuclear Information System (INIS)

    Oertel, J. A.; Archuleta, T. N.

    2014-01-01

    Microchannel plate (MCP), microstrip transmission line based, gated x-ray detectors used at the premier ICF laser facilities have a drop in gain as a function of mircostrip length that can be greater than 50% over 40 mm. These losses are due to ohmic losses in a microstrip coating that is less than the optimum electrical skin depth. The electrical skin depth for a copper transmission line at 3 GHz is 1.2 μm while the standard microstrip coating thickness is roughly half a single skin depth. Simply increasing the copper coating thickness would begin filling the MCP pores and limit the number of secondary electrons created in the MCP. The current coating thickness represents a compromise between gain and ohmic loss. We suggest a novel solution to the loss problem by overcoating the copper transmission line with five electrical skin depths (∼6 μm) of Beryllium. Beryllium is reasonably transparent to x-rays above 800 eV and would improve the carrier current on the transmission line. The net result should be an optically flat photocathode response with almost no measurable loss in voltage along the transmission line

  17. Test-beam and laboratory characterisation of the TORCH prototype detector

    CERN Document Server

    Ros, A; Castillo-Garcia, L; Conneely, T; Cussans, D; Foehl, K; Forty, R; Frei, C; Gao, R; Gys, T; Harnew, N; Milnes, J; Piedigrossi, D; Rademacker, J; Van Dijk, M

    2017-01-01

    The TORCH time-of-flight (TOF) detector is being developed to provide particle identification up to a momentum of 10 GeV/c over a flight distance of 10 m. It has a DIRC-like construction with View the MathML source10mm thick synthetic amorphous fused-silica plates as a Cherenkov radiator. Photons propagate by total internal reflection to the plate periphery where they are focused onto an array of customised position-sensitive micro-channel plate (MCP) detectors. The goal is to achieve a 15 ps time-of-flight resolution per incident particle by combining arrival times from multiple photons. The MCPs have pixels of effective size 0.4 mm×6.6 mm2 in the vertical and horizontal directions, respectively, by incorporating a novel charge-sharing technique to improve the spatial resolution to better than the pitch of the readout anodes. Prototype photon detectors and readout electronics have been tested and calibrated in the laboratory. Preliminary results from testbeam measurements of a prototype TORCH detector are a...

  18. Evaluation of BICRON NE MCP DXT-RAD passive extremity dosemeter

    CERN Document Server

    Yuen, P S; Frketich, G; Rotunda, J

    1999-01-01

    Passive extremity dosemeters currently used in dosimetry communities worldwide have shortcomings. In general, an extremity dosemeter has too thick a detector element, and the dosemeter response is highly energy dependent for beta rays with energies ranging from 200 keV to 2 MeV. It often does not have dosemeter identification, causing problems in the chain of custody. It is often read manually, rendering reading/packing operations very labour intensive. As a result of collaboration between AECL and BICRON NE, a new extremity dosemeter, incorporating a highly sensitive LiF:Mg,Cu,P TLD and tentatively code named MCP DXT-RAD, was developed. It has been evaluated for radiological performance against an ISO draft standard for extremity dosemeters in twelve categories: homogeneity, detection threshold, beta ray energy response, beta angular response, photon energy response, photon angular response, reproducibility, stability under various climatic conditions, linearity, residue, self irradiation, and effect of ligh...

  19. VIDA COMERCIAL DE PITAHAYA AMARILLA TRATADA CON 1-MCP

    Directory of Open Access Journals (Sweden)

    LILIANA SERNA-COCK

    Full Text Available 1-metilciclopropeno (1-MCP, un inhibidor del etileno, ha sido utilizado para extender la vida comercial de diferentes frutas. El objetivo de este trabajo fue evaluar el efecto de la aplicación de soluciones acuosas de 10, 100 y 200 gL-1 de 1-MCP, con tiempos de exposición de 1, 5 y 10 minutos, sobre la vida comercial de pitahaya amarilla en estado de madurez 4. Durante 15 días de almacenamiento (25 ± 2°C y 75% de humedad relativa, se evaluaron cambios físicos como la pérdida de peso y la aparición de pardeamiento; y se midieron cambios químicos como sólidos solubles, pH, acidez e índice de madurez. Se presentaron diferencias significativas entre los tratamientos. Los resultados demostraron que aplicaciones de 200 gL-1 de 1-MCP durante 10 minutos prolongó por tres días, la vida comercial de la pitahaya amarilla, y redujo cambios en los sólidos solubles y la acidez

  20. The MCP-4/MCP-1 ratio in plasma is a candidate circadian biomarker for chronic post-traumatic stress disorder

    Science.gov (United States)

    Dalgard, C; Eidelman, O; Jozwik, C; Olsen, C H; Srivastava, M; Biswas, R; Eudy, Y; Rothwell, S W; Mueller, G P; Yuan, P; Drevets, W C; Manji, H K; Vythlingam, M; Charney, D S; Neumeister, A; Ursano, R J; Jacobowitz, D M; Pollard, H B; Bonne, O

    2017-01-01

    Post-traumatic stress disorder (PTSD) is psychiatric disease, which can occur following exposure to traumatic events. PTSD may be acute or chronic, and can have a waxing and waning course of symptoms. It has been hypothesized that proinflammatory cytokines and chemokines in the cerebrospinal fluid (CSF) or plasma might be mediators of the psychophysiological mechanisms relating a history of trauma exposure to changes in behavior and mental health disorders, and medical morbidity. Here we test the cytokine/chemokine hypothesis for PTSD by examining levels of 17 classical cytokines and chemokines in CSF, sampled at 0900 hours, and in plasma sampled hourly for 24 h. The PTSD and healthy control patients are from the NIMH Chronic PTSD and healthy control cohort, initially described by Bonne et al. (2011), in which the PTSD patients have relatively low comorbidity for major depressive disorder (MDD), drug or alcohol use. We find that in plasma, but not CSF, the bivariate MCP4 (CCL13)/ MCP1(CCL2) ratio is ca. twofold elevated in PTSD patients compared with healthy controls. The MCP-4/MCP-1 ratio is invariant over circadian time, and is independent of gender, body mass index or the age at which the trauma was suffered. By contrast, MIP-1β is a candidate biomarker for PTSD only in females, whereas TARC is a candidate biomarker for PTSD only in males. It remains to be discovered whether these disease-specific differences in circadian expression for these specific immune signaling molecules are biomarkers, surrogates, or drivers for PTSD, or whether any of these analytes could contribute to therapy. PMID:28170001

  1. Development of MCP transient operation strategy for the SMART-P

    International Nuclear Information System (INIS)

    Yoo, S. E.; Choi, B. S.; Kang, H. O.; Yoon, J. H.; Ji, S. K.

    2003-01-01

    SMART-P MCP(Main Coolant Pump) transient operation strategies are developed. A Modular Modeling System (MMS) computer code is used for the evaluation of the developed operation strategies. In the SMART-P, normal operating modes are classified into MCP high speed(3600 rpm) mode and MCP low speed mode. Also, natural circulation mode is defined as a performance test case. MCP operation transients occur when changing modes from one to another, and system parameters(core power, system pressure, temperature) are having transients. These transients affect on system performance and, in some cases, limit system operation. In this study, MCP operation strategies are developed and obtained acceptable results

  2. Efficiency and rate capability studies of the time-of-flight detector for isochronous mass measurements of stored short-lived nuclei with the FRS-ESR facility

    Energy Technology Data Exchange (ETDEWEB)

    Kuzminchuk-Feuerstein, Natalia; Fabian, Benjamin [II. Physikalisches Institut, Justus-Liebig-Universität, 35392 Gießen (Germany); GSI Helmholtzzentrum für Schwerionenforschung, 64291 Darmstadt (Germany); Diwisch, Marcel [II. Physikalisches Institut, Justus-Liebig-Universität, 35392 Gießen (Germany); Plaß, Wolfgang R., E-mail: Wolfgang.R.Plass@exp2.physik.uni-giessen.de [II. Physikalisches Institut, Justus-Liebig-Universität, 35392 Gießen (Germany); GSI Helmholtzzentrum für Schwerionenforschung, 64291 Darmstadt (Germany); Geissel, Hans; Ayet San Andrés, Samuel; Dickel, Timo; Knöbel, Ronja; Scheidenberger, Christoph [II. Physikalisches Institut, Justus-Liebig-Universität, 35392 Gießen (Germany); GSI Helmholtzzentrum für Schwerionenforschung, 64291 Darmstadt (Germany); Sun, Baohua [II. Physikalisches Institut, Justus-Liebig-Universität, 35392 Gießen (Germany); Weick, Helmut [GSI Helmholtzzentrum für Schwerionenforschung, 64291 Darmstadt (Germany)

    2016-06-11

    A time-of-flight (TOF) detector is used for Isochronous Mass Spectrometry (IMS) with the projectile fragment separator FRS and the heavy-ion storage ring ESR. Exotic nuclei are spatially separated in flight with the FRS at about 70% of the speed of light and are injected into the ESR. The revolution times of the stored ions circulating in the ESR are measured with a thin transmission foil detector. When the ions penetrate the thin detector foil, secondary electrons (SEs) are emitted from the surface and provide the timing information in combination with microchannel plate (MCP) detectors. The isochronous transport of the SEs is performed by perpendicular superimposed electric and magnetic fields. The detection efficiency and the rate capability of the TOF detector have been studied in simulations and experiments. As a result the performance of the TOF detector has been improved substantially: (i) The SE collection efficiency was doubled by use of an optimized set of electric and magnetic field values; now SEs from almost the full area of the foil are transmitted to the MCP detectors. (ii) The rate capability of the TOF detector was improved by a factor of four by the use of MCPs with 5 μm pore size. (iii) With these MCPs and a carbon foil with a reduced thickness of 10 μg/cm{sup 2} the number of recorded revolutions in the ESR has been increased by nearly a factor of 10. The number of recorded revolutions determine the precision of the IMS experiments. Heavy-ion measurements were performed with neon ions at 322 MeV/u and uranium fission fragments at about 370 MeV/u. In addition, measurements with an alpha source were performed in the laboratory with a duplicate of the TOF detector.

  3. Efficiency and rate capability studies of the time-of-flight detector for isochronous mass measurements of stored short-lived nuclei with the FRS-ESR facility

    International Nuclear Information System (INIS)

    Kuzminchuk-Feuerstein, Natalia; Fabian, Benjamin; Diwisch, Marcel; Plaß, Wolfgang R.; Geissel, Hans; Ayet San Andrés, Samuel; Dickel, Timo; Knöbel, Ronja; Scheidenberger, Christoph; Sun, Baohua; Weick, Helmut

    2016-01-01

    A time-of-flight (TOF) detector is used for Isochronous Mass Spectrometry (IMS) with the projectile fragment separator FRS and the heavy-ion storage ring ESR. Exotic nuclei are spatially separated in flight with the FRS at about 70% of the speed of light and are injected into the ESR. The revolution times of the stored ions circulating in the ESR are measured with a thin transmission foil detector. When the ions penetrate the thin detector foil, secondary electrons (SEs) are emitted from the surface and provide the timing information in combination with microchannel plate (MCP) detectors. The isochronous transport of the SEs is performed by perpendicular superimposed electric and magnetic fields. The detection efficiency and the rate capability of the TOF detector have been studied in simulations and experiments. As a result the performance of the TOF detector has been improved substantially: (i) The SE collection efficiency was doubled by use of an optimized set of electric and magnetic field values; now SEs from almost the full area of the foil are transmitted to the MCP detectors. (ii) The rate capability of the TOF detector was improved by a factor of four by the use of MCPs with 5 μm pore size. (iii) With these MCPs and a carbon foil with a reduced thickness of 10 μg/cm 2 the number of recorded revolutions in the ESR has been increased by nearly a factor of 10. The number of recorded revolutions determine the precision of the IMS experiments. Heavy-ion measurements were performed with neon ions at 322 MeV/u and uranium fission fragments at about 370 MeV/u. In addition, measurements with an alpha source were performed in the laboratory with a duplicate of the TOF detector.

  4. Silicon-micromachined microchannel plates

    International Nuclear Information System (INIS)

    Beetz, Charles P.; Boerstler, Robert; Steinbeck, John; Lemieux, Bryan; Winn, David R.

    2000-01-01

    Microchannel plates (MCP) fabricated from standard silicon wafer substrates using a novel silicon micromachining process, together with standard silicon photolithographic process steps, are described. The resulting SiMCP microchannels have dimensions of ∼0.5 to ∼25 μm, with aspect ratios up to 300, and have the dimensional precision and absence of interstitial defects characteristic of photolithographic processing, compatible with positional matching to silicon electronics readouts. The open channel areal fraction and detection efficiency may exceed 90% on plates up to 300 mm in diameter. The resulting silicon substrates can be converted entirely to amorphous quartz (qMCP). The strip resistance and secondary emission are developed by controlled depositions of thin films, at temperatures up to 1200 deg. C, also compatible with high-temperature brazing, and can be essentially hydrogen, water and radionuclide-free. Novel secondary emitters and cesiated photocathodes can be high-temperature deposited or nucleated in the channels or the first strike surface. Results on resistivity, secondary emission and gain are presented

  5. Optically sensitive Medipix2 detector for adaptive optics wavefront sensing

    CERN Document Server

    Vallerga, John; Tremsina, Anton; Siegmund, Oswald; Mikulec, Bettina; Clark, Allan G; CERN. Geneva

    2005-01-01

    A new hybrid optical detector is described that has many of the attributes desired for the next generation adaptive optics (AO) wavefront sensors. The detector consists of a proximity focused microchannel plate (MCP) read out by multi-pixel application specific integrated circuit (ASIC) chips developed at CERN ("Medipix2") with individual pixels that amplify, discriminate and count input events. The detector has 256 x 256 pixels, zero readout noise (photon counting), can be read out at 1 kHz frame rates and is abutable on 3 sides. The Medipix2 readout chips can be electronically shuttered down to a temporal window of a few microseconds with an accuracy of 10 ns. When used in a Shack-Hartmann style wavefront sensor, a detector with 4 Medipix chips should be able to centroid approximately 5000 spots using 7 x 7 pixel sub-apertures resulting in very linear, off-null error correction terms. The quantum efficiency depends on the optical photocathode chosen for the bandpass of interest.

  6. Optically sensitive Medipix2 detector for adaptive optics wavefront sensing

    International Nuclear Information System (INIS)

    Vallerga, John; McPhate, Jason; Tremsin, Anton; Siegmund, Oswald; Mikulec, Bettina; Clark, Allan

    2005-01-01

    A new hybrid optical detector is described that has many of the attributes desired for the next generation adaptive optics (AO) wavefront sensors. The detector consists of a proximity focused microchannel plate (MCP) read out by multi-pixel application specific integrated circuit (ASIC) chips developed at CERN ('Medipix2') with individual pixels that amplify, discriminate and count input events. The detector has 256x256 pixels, zero readout noise (photon counting), can be read out at 1 kHz frame rates and is abutable on 3 sides. The Medipix2 readout chips can be electronically shuttered down to a temporal window of a few microseconds with an accuracy of 10 ns. When used in a Shack-Hartmann style wavefront sensor, a detector with 4 Medipix chips should be able to centroid approximately 5000 spots using 7x7 pixel sub-apertures resulting in very linear, off-null error correction terms. The quantum efficiency depends on the optical photocathode chosen for the bandpass of interest

  7. Simultaneous resolution of spectral and temporal properties of UV and visible fluorescence using single-photon counting with a position-sensitive detector

    International Nuclear Information System (INIS)

    Kelly, L.A.; Trunk, J.G.; Polewski, K.; Sutherland, J.C.

    1995-01-01

    A new fluorescence spectrometer has been assembled at the U9B beamline of the National Synchrotron Light Source to allow simultaneous multiwavelength and time-resolved fluorescence detection, as well as spatial imaging of the sample fluorescence. The spectrometer employs monochromatized, tunable UV and visible excitation light from a synchrotron bending magnet and an imaging spectrograph equipped with a single-photon sensitive emission detector. The detector is comprised of microchannel plates in series, with a resistive anode for encoding the position of the photon-derived current. The centroid position of the photon-induced electron cascade is derived in a position analyzer from the four signals measured at the corners of the resistive anode. Spectral information is obtained by dispersing the fluorescence spectrum across one dimension of the detector photocathode. Timing information is obtained by monitoring the voltage divider circuit at the last MCP detector. The signal from the MCP is used as a ''start'' signal to perform a time-correlated single photon counting experiment. The analog signal representing the position, and hence wavelength, is digitized concomitantly with the start/stop time difference and stored in the two-dimensional histogramming memory of a multiparameter analyzer

  8. Improved lifetime of microchannel-plate PMTs

    Energy Technology Data Exchange (ETDEWEB)

    Lehmann, A., E-mail: lehmann@physik.uni-erlangen.de [Physikalisches Institut IV, Friedrich Alexander-University of Erlangen-Nuremberg, Erlangen (Germany); Britting, A.; Eyrich, W.; Uhlig, F. [Physikalisches Institut IV, Friedrich Alexander-University of Erlangen-Nuremberg, Erlangen (Germany); Dzhygadlo, R.; Gerhardt, A.; Götzen, K.; Höhler, R.; Kalicy, G.; Kumawat, H.; Lehmann, D.; Lewandowski, B.; Patsyuk, M.; Peters, K.; Schepers, G.; Schmitt, L.; Schwarz, C.; Schwiening, J.; Traxler, M.; Zühlsdorf, M. [GSI Helmholtzzentrum für Schwerionenforschung GmbH, Darmstadt (Germany); and others

    2014-12-01

    The charged particle identification at the PANDA experiment will be mainly performed with DIRC detectors. Because of their advantageous properties the preferred photon sensors are MCP-PMTs. However, until recently these devices showed serious aging problems which resulted in a diminishing quantum efficiency (QE) of the photo cathode. By applying innovative countermeasures against the aging causes, the manufacturers recently succeeded in drastically improving the lifetime of MCP-PMTs. Especially the application of an ALD coating technique to seal the material of the micro-channels proves very powerful and results in a lifetime of ≈6C/cm{sup 2} integrated anode charge without a substantial QE degradation for the latest PHOTONIS XP85112. This paper will present a comparative measurement of the lifetime of several older and recent MCP-PMTs demonstrating this progress.

  9. Investigation of image distortion due to MCP electronic readout misalignment and correction via customized GUI application

    Science.gov (United States)

    Vitucci, G.; Minniti, T.; Tremsin, A. S.; Kockelmann, W.; Gorini, G.

    2018-04-01

    The MCP-based neutron counting detector is a novel device that allows high spatial resolution and time-resolved neutron radiography and tomography with epithermal, thermal and cold neutrons. Time resolution is possible by the high readout speeds of ~ 1200 frames/sec, allowing high resolution event counting with relatively high rates without spatial resolution degradation due to event overlaps. The electronic readout is based on a Timepix sensor, a CMOS pixel readout chip developed at CERN. Currently, a geometry of a quad Timepix detector is used with an active format of 28 × 28 mm2 limited by the size of the Timepix quad (2 × 2 chips) readout. Measurements of a set of high-precision micrometers test samples have been performed at the Imaging and Materials Science & Engineering (IMAT) beamline operating at the ISIS spallation neutron source (U.K.). The aim of these experiments was the full characterization of the chip misalignment and of the gaps between each pad in the quad Timepix sensor. Such misalignment causes distortions of the recorded shape of the sample analyzed. We present in this work a post-processing image procedure that considers and corrects these effects. Results of the correction will be discussed and the efficacy of this method evaluated.

  10. MCP-1 expressed by osteoclasts stimulates osteoclastogenesis in an autocrine/paracrine manner

    International Nuclear Information System (INIS)

    Miyamoto, Kana; Ninomiya, Ken; Sonoda, Koh-Hei; Miyauchi, Yoshiteru; Hoshi, Hiroko; Iwasaki, Ryotaro; Miyamoto, Hiroya

    2009-01-01

    Monocyte chemoattractant protein-1 (MCP-1) is a chemokine that plays a critical role in the recruitment and activation of leukocytes. Here, we describe that multinuclear osteoclast formation was significantly inhibited in cells derived from MCP-1-deficient mice. MCP-1 has been implicated in the regulation of osteoclast cell-cell fusion; however defects of multinuclear osteoclast formation in the cells from mice deficient in DC-STAMP, a seven transmembrane receptor essential for osteoclast cell-cell fusion, was not rescued by recombinant MCP-1. The lack of MCP-1 in osteoclasts resulted in a down-regulation of DC-STAMP, NFATc1, and cathepsin K, all of which were highly expressed in normal osteoclasts, suggesting that osteoclast differentiation was inhibited in MCP-1-deficient cells. MCP-1 alone did not induce osteoclastogenesis, however, the inhibition of osteoclastogenesis in MCP-1-deficient cells was restored by addition of recombinant MCP-1, indicating that osteoclastogenesis was regulated in an autocrine/paracrine manner by MCP-1 under the stimulation of RANKL in osteoclasts.

  11. High resolution time-of-flight (TOF) detector for particle identification

    Energy Technology Data Exchange (ETDEWEB)

    Boehm, Merlin; Lehmann, Albert; Pfaffinger, Markus; Uhlig, Fred [Physikalisches Institut, Universitaet Erlangen-Nuernberg (Germany); Collaboration: PANDA-Collaboration

    2016-07-01

    Several prototype tests were performed with the PANDA DIRC detectors at the CERN T9 beam line. A mixed hadron beam with pions, kaons and protons was used at momenta from 2 to 10 GeV/c. For these tests a good particle identification was mandatory. We report about a high resolution TOF detector built especially for this purpose. It consists of two stations each consisting of a Cherenkov radiator read out by a Microchannel-Plate Photomultiplier (MCP-PMT) and a Scintillating Tile (SciTil) counter read out by silicon photomultipliers (SiPMs). With a flight path of 29 m a pion/kaon separation up to 5 GeV/c and a pion/proton separation up to 10 GeV/c was obtained. From the TOF resolutions of different counter combinations the time resolution (sigma) of the individual MCP-PMTs and SciTils was determined. The best counter reached a time resolution of 50 ps.

  12. Neutron imaging plates

    International Nuclear Information System (INIS)

    Niimura, Nobuo

    1995-01-01

    Imaging plates have been used in the field of medical diagnosis since long ago, but their usefulness was verified as the two-dimensional detector for analyzing the X-ray crystalline structure of high bio molecules like protein, and they have contributed to the remarkable progress in this field. The great contribution is due to the excellent features, such as the detection efficiency of about 100%, the positional resolution smaller than 0.2 mm, the dynamic range of five digits, and the area of several hundreds mm square. The neutron imaging plates have not yet obtained the sufficient results. It was planned to construct the neutron diffractometer for biological matters, and to put imaging plate neutron detectors (IP-ND) to practical use as the detector. The research on the development of IP-NDs was carried out, and the IPp-NDs having the performance comparable with that for X-ray were able to be produced. Imaging plates are the integral type two-dimensional radiation detector using photostimulated luminescence matters, and their principle is explained. As to neutron imaging plates, the converter, neutron detection efficiency and the flight of secondary particles in photo-stimulated luminescence matters are described. As for the present state of development of neutron imaging plates, the IP-NDs made for trial, the dynamic range, the positional resolution, the detection efficiency and the kinds of converters, and the application of IP-NDs are reported. (K.I.)

  13. Modular Engine Noise Component Prediction System (MCP) Program Users' Guide

    Science.gov (United States)

    Golub, Robert A. (Technical Monitor); Herkes, William H.; Reed, David H.

    2004-01-01

    This is a user's manual for Modular Engine Noise Component Prediction System (MCP). This computer code allows the user to predict turbofan engine noise estimates. The program is based on an empirical procedure that has evolved over many years at The Boeing Company. The data used to develop the procedure include both full-scale engine data and small-scale model data, and include testing done by Boeing, by the engine manufacturers, and by NASA. In order to generate a noise estimate, the user specifies the appropriate engine properties (including both geometry and performance parameters), the microphone locations, the atmospheric conditions, and certain data processing options. The version of the program described here allows the user to predict three components: inlet-radiated fan noise, aft-radiated fan noise, and jet noise. MCP predicts one-third octave band noise levels over the frequency range of 50 to 10,000 Hertz. It also calculates overall sound pressure levels and certain subjective noise metrics (e.g., perceived noise levels).

  14. Capacitively coupled pickup in MCP-based photodetectors using a conductive metallic anode

    Energy Technology Data Exchange (ETDEWEB)

    Angelico, E.; Seiss, T. [Enrico Fermi Institute, University of Chicago, 5640 S Ellis Ave, Chicago, IL 60637 (United States); Adams, B. [Incom, Inc., 294 SouthBridge Rd, Charlton, Massachusetts 01507 (United States); Elagin, A.; Frisch, H.; Spieglan, E. [Enrico Fermi Institute, University of Chicago, 5640 S Ellis Ave, Chicago, IL 60637 (United States)

    2017-02-21

    We have designed and tested a robust 20×20 cm{sup 2} thin metal film internal anode capacitively coupled to an external array of signal pads or micro-strips for use in fast microchannel plate photodetectors. The internal anode, in this case a 10 nm-thick NiCr film deposited on a 96% pure Al{sub 2}O{sub 3} 3 mm-thick ceramic plate and connected to HV ground, provides the return path for the electron cascade charge. The multi-channel pickup array consists of a printed-circuit card or glass plate with metal signal pickups on one side and the signal ground plane on the other. The pickup can be put in close proximity to the bottom outer surface of the sealed photodetector, with no electrical connections through the photodetector hermetic vacuum package other than a single ground connection to the internal anode. Two pickup patterns were tested using a small commercial MCP-PMT as the signal source: 1) parallel 50 Ω 25-cm-long micro-strips with an analog bandwidth of 1.5 GHz, and 2) a 20×20 cm{sup 2} array of 2-dimensional square ‘pads’ with sides of 1.27 cm or 2.54 cm. The rise-time of the fast input pulse is maintained for both pickup patterns. For the pad pattern, we observe 80% of the directly coupled amplitude. For the strip pattern we measure 34% of the directly coupled amplitude on the central strip of a broadened signal. The physical decoupling of the photodetector from the pickup pattern allows easy customization for different applications while maintaining high analog bandwidth.

  15. Gas filled detectors

    International Nuclear Information System (INIS)

    Stephan, C.

    1993-01-01

    The main types of gas filled nuclear detectors: ionization chambers, proportional counters, parallel-plate avalanche counters (PPAC) and microstrip detectors are described. New devices are shown. A description of the processes involved in such detectors is also given. (K.A.) 123 refs.; 25 figs.; 3 tabs

  16. Associations between Deceased-Donor Urine MCP-1 and Kidney Transplant Outcomes.

    Science.gov (United States)

    Mansour, S G; Puthumana, J; Reese, P P; Hall, I E; Doshi, M D; Weng, F L; Schröppel, B; Thiessen-Philbrook, H; Bimali, M; Parikh, C R

    2017-07-01

    Existing methods to predict recipient allograft function during deceased-donor kidney procurement are imprecise. Understanding the potential renal reparative role for monocyte chemoattractant protein-1 (MCP-1), a cytokine involved in macrophage recruitment after injury, might help predict allograft outcomes. We conducted a sub-study of the multicenter prospective Deceased Donor Study cohort, which evaluated deceased kidney donors from five organ procurement organizations from May 2010 to December 2013. We measured urine MCP-1 (uMCP-1) concentrations from donor samples collected at nephrectomy to determine associations with donor acute kidney injury (AKI), recipient delayed graft function (DGF), 6-month estimated GFR (eGFR), and graft failure. We also assessed perfusate MCP-1 concentrations from pumped kidneys for associations with DGF and 6-month eGFR. AKI occurred in 111 (9%) donors. Median (interquartile range) uMCP-1 concentration was higher in donors with AKI compared to donors without AKI (1.35 [0.41-3.93] ng/ml vs. 0.32 [0.11-0.80] ng/ml, p<0.001). DGF occurred in 756 (31%) recipients, but uMCP-1 was not independently associated with DGF. Higher donor uMCP-1 concentrations were independently associated with higher 6-month eGFR in those without DGF [0.77 (0.10, 1.45) ml/min/1.73m 2 per doubling of uMCP1]. However, there were no independent associations between uMCP-1 and graft failure over a median follow-up of about 2 years. Lastly, perfusate MCP-1 concentrations significantly increased during pump perfusion but were not associated with DGF or 6-month eGFR. Donor uMCP-1 concentrations were modestly associated with higher recipient 6-month eGFR in those without DGF. However, the results suggest that donor uMCP-1 has minimal clinical utility given no associations with graft failure.

  17. Dynamic Characterizations of an 8-frame, Half-Strip, High-speed X-ray Microchannel Plate Imager

    International Nuclear Information System (INIS)

    Ken Moy; Ming Wu; Craig Kruschwitz; Aric Tibbits; Matt Griffin; Greg Rochau

    2008-01-01

    High-speed microchannel plate (MCP)-based imagers are critical detectors for x-ray diagnostics employed on Z-experiments at Sandia National Laboratories (SNL) to measure time-resolved x-ray spectra and to image dynamic hohlraums. A multiframe design using eight half strips in one imager permits recordings of radiation events in discrete temporal snapshots to yield a time-evolved movie. We present data using various facilities to characterize the performance of this design. These characterization studies include DC and pulsed-voltage biased measurements in both saturated and linear operational regimes using an intense, short-pulsed UV laser. Electrical probe measurements taken to characterize the shape of the HV pulse propagating across the strips help to corroborate the spatial gain dependence

  18. The chemokine MCP-1 (CCL2) in the host interaction with cancer: a foe or ally?

    Science.gov (United States)

    Yoshimura, Teizo

    2018-01-29

    Macrophages are one of the most abundant leukocyte populations infiltrating tumor tissues and can exhibit both tumoricidal and tumor-promoting activities. In 1989, we reported the purification of monocyte chemoattractant protein-1 (MCP-1) from culture supernatants of mitogen-activated peripheral blood mononuclear cells and tumor cells. MCP-1 is a potent monocyte-attracting chemokine, identical to the previously described lymphocyte-derived chemotactic factor or tumor-derived chemotactic factor, and greatly contributes to the recruitment of blood monocytes into sites of inflammatory responses and tumors. Because in vitro-cultured tumor cells often produce significant amounts of MCP-1, tumor cells are considered to be the main source of MCP-1. However, various non-tumor cells in the tumor stroma also produce MCP-1 in response to stimuli. Studies performed in vitro and in vivo have provided evidence that MCP-1 production in tumors is a consequence of complex interactions between tumor cells and non-tumor cells and that both tumor cells and non-tumor cells contribute to the production of MCP-1. Although MCP-1 production was once considered to be a part of host defense against tumors, it is now believed to regulate the vicious cycle between tumor cells and macrophages that promotes the progression of tumors.Cellular and Molecular Immunology advance online publication, 29 January 2018; doi:10.1038/cmi.2017.135.

  19. Associations Between Deceased-Donor Urine MCP-1 and Kidney Transplant Outcomes

    Directory of Open Access Journals (Sweden)

    S.G. Mansour

    2017-07-01

    Discussion: Donor uMCP-1 concentrations were modestly associated with higher recipient 6-month eGFR in those without DGF. However, the results suggest that donor uMCP-1 has minimal clinical utility given no associations with graft failure.

  20. Circulating MCP-1 level and вˆј2518 gene polymorphism as a ...

    African Journals Online (AJOL)

    Azza M. Hassan

    that plays an important role in the recruitment of monocytes/macrophages into renal tubulointer- stitium. A biallelic A/G polymorphism at position 2518 in the MCP-1 gene was found ..... minurea, but also with UAE in their type 2 diabetic patients. This is explained by the pivotal role played by increased MCP-. 1 production due ...

  1. Monocyte chemoattractant protein 1 (MCP-1) in temporal arteritis and polymyalgia rheumatica

    DEFF Research Database (Denmark)

    Ellingsen, T; Elling, P; Olson, A

    2000-01-01

    was localised to the vessel wall in patients with TA. In TA, PMR, and healthy controls MCP-1 was quantified by enzyme linked immunosorbent assay (ELISA) in plasma. RESULTS: MCP-1 was localised to the majority of mononuclear cells, some smooth muscle cells, and giant cells in the arterial biopsy specimens from...

  2. Poster - 24: Characterization of the energy dependence of high-sensitivity MCP-N TLD and Al2O3:C OSLD in-vivo dosimetry systems for 40–100 kVp energies

    Energy Technology Data Exchange (ETDEWEB)

    Poirier, Yannick; Kuznetsova, Svetlana; Barajas, Eduardo Villarreal [Tom Baker Cancer Centre, Calgary AB, University of Calgary, Calgary AB, Tom Baker Cancer Center/University of Calgary, Calgary AB (Canada)

    2016-08-15

    Purpose: To characterize the energy dependence of high-sensitivity MCP-N TLD and Al{sub 2}O{sub 3}:C OSLD dosimetry systems at low (40–100 kVp) energies for in-vivo dosimetry. Methods: We assessed the variation of response with energy of two detectors in the 40–100 kVp energy range: high-sensitivity MCP-N TLDs (LiF:Mg,Cu,P) and OSLDs (Al{sub 2}O{sub 3}:C). The detectors were irradiated with an XRad 320ix biological irradiator under reference conditions. The delivered dose was 10 cGy for 7 beam qualities ranging from 40–100 kVp, 1.7–4.0 mm Al, and effective energies 26.9–37.9 keV. Both sets of detectors were also irradiated under reference conditions at 6 MV using a Varian Clinac 21Ex to assess the change in response from high-energy beams. Results: The MCP-N high-sensitivity TLDs were relatively insensitive to energies in the kV range, as their response varied by ±5%, i.e. well within the reproducibility limits of these detectors. However, the OSLDs exhibited a linearly-decreasing response with energy with a response 18.7% higher at 40 kVp than at 100 kVp for the same nominal dose. Compared to the 6 MV beams used in conventional radiotherapy, OSLDs responded 3.3–3.9 times higher depending on beam quality while the MCP-N TLD response was unchanged within experimental uncertainty. Conclusions: Unlike the more commonly used TLD-100, the high-sensitivity MCP-N TLDs exhibit little to no energy response. OSLDs are shown to be highly energy-dependent, both from MV to kV and within the kV range.

  3. Electron optics design of an 8-in. spherical MCP-PMT

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Ping, E-mail: chenping@opt.cn [Key Laboratory of Ultra-fast photoelectric Diagnostics Technology, Xi’an Institute of Optics and Precision Mechanics (XIOPM), Chinese Academy of Sciences, Xi’an 710119 (China); University of Chinese Academy of Sciences, Beijing 100049 (China); Collaborative Innovation Center of Extreme Optics, Shanxi University, Taiyuan 030006, Shanxi (China); Tian, Jinshou [Key Laboratory of Ultra-fast photoelectric Diagnostics Technology, Xi’an Institute of Optics and Precision Mechanics (XIOPM), Chinese Academy of Sciences, Xi’an 710119 (China); Collaborative Innovation Center of Extreme Optics, Shanxi University, Taiyuan 030006, Shanxi (China); Qian, Sen; Zhao, Tianchi [Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (China); Liu, Hulin; Wei, Yonglin; Sai, Xiaofeng; He, Jianping; Wang, Xing; Lu, Yu [Key Laboratory of Ultra-fast photoelectric Diagnostics Technology, Xi’an Institute of Optics and Precision Mechanics (XIOPM), Chinese Academy of Sciences, Xi’an 710119 (China); Chen, Lin; Guo, Lehui; Pei, Chengquan; Hui, Dandan [Key Laboratory of Ultra-fast photoelectric Diagnostics Technology, Xi’an Institute of Optics and Precision Mechanics (XIOPM), Chinese Academy of Sciences, Xi’an 710119 (China); University of Chinese Academy of Sciences, Beijing 100049 (China)

    2017-03-11

    This paper discusses the electron optical system of an 8-in. spherical MCP-PMT. The MCP assembly, the supporting pole and the supply voltages are carefully designed to optimize the photoelectron collection efficiency and the transit time spread. Coating the MCP nickel-chromium electrode with an additional high secondary emission material is employed to make a breakthrough on the collection efficiency. With the simulation software CST, the Finite Integration method and the Monte Carlo method are combined to evaluate the collection efficiency, the time properties and the Earth's magnetic field effects. Simulation results show that the photocathode active solid angle is over 3.5 πsr, the average collection efficiency can exceed 95% with the coated MCP and the mean transit time spread is 2.2 ns for a typical electric potential of 500 V applied between the photocathode and the MCP input facet. The prototype and the measured single photoelectron spectrum are also presented.

  4. Study of the effects of 1-MCP to blueberry under cold storage

    Science.gov (United States)

    Tao, Shenchen; Chu, Huailiang; Chen, Xiaomin; Yuan, Huwei; Qiu, Lingling; Zhao, Liang; Yan, Daoliang; Zheng, Bingsong

    2017-04-01

    Blueberry is one of the thinnest exocarp fruits in the world, which is difficult to keep fresh due to the special structure of its skin. 1-Methlcyclopropene (1-MCP) is able to combine with ethylene(ETH) receptor. In this study we investigated the effect of 1-MCP on rotting rate, weight loss ratio, soluble sugar content, titratable acid content, antioxidant enzyme activities and malondialdehyde (MDA) content in blueberry (Vaccinium corymbosun ‘O Neal’ and ‘North Road’) under cold storage. 1-MCP reduced the rotting rate, weight loss ratio and MDA content, while keeping high-leveled stability in antioxidant enzyme activities, soluble sugar content and titratable acid content. These results showed the role of 1-MCP in alleviating the negative effects of blueberry and suggested that 1-MCP could be used as a preservative for keeping thin exocarp fruit in fresh.

  5. Increased MCP-1 gene expression in monocytes of severe OSA patients and under intermittent hypoxia.

    Science.gov (United States)

    Chuang, Li-Pang; Chen, Ning-Hung; Lin, Yuling; Ko, Wen-Shan; Pang, Jong-Hwei S

    2016-03-01

    Obstructive sleep apnea (OSA) is known to be a risk factor of coronary artery disease. Monocyte chemoattractant protein-1 (MCP-1), as a critical factor for monocyte infiltration, is known to play a role in the development of atherosclerosis. This study aimed to investigate the effect of intermittent hypoxia, the hallmark of OSA, on the MCP-1 expression of monocytes. Peripheral blood was sampled from 61 adults enrolled for suspected OSA. RNA was prepared from the isolated monocytes for the analysis of MCP-1. The effect of in vitro intermittent hypoxia on the regulation and function of MCP-1 was investigated on THP-1 monocytic cells and human monocytes. The mRNA and secreted protein levels were investigated by RT/real-time PCR and enzyme-linked immunosorbent assay, respectively. Monocytic MCP-1 gene expression was found to be increased significantly in severe OSA patients. In vitro intermittent hypoxia was demonstrated to increase the mRNA and protein expression levels of MCP-1 dose- and time-dependently in THP-1 monocytic cells. The MCP-1 mRNA expression in monocytes isolated from OSA patient was induced to a much higher level compared to that from normal control. Pre-treatment with inhibitor for p42/44 MAPK or p38 MAPK suppressed the activation of MCP-1 expression by intermittent hypoxia. This is the first study to demonstrate the increase of MCP-1 gene expression in monocytes of severe OSA patients. In addition, monocytic MCP-1 gene expression can be induced under intermittent hypoxia.

  6. Functionalized Nano-Film Microchannel Plate: A Single High Aspect Ratio Device for High Resolution, Low Noise Astronomical Imaging, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — The proposed innovation is to apply proven nano-film technology to enable Microchannel plate (MCP) devices to be manufactured on a range of insulating substrates and...

  7. Detectors - Electronics

    International Nuclear Information System (INIS)

    Bregeault, J.; Gabriel, J.L.; Hierle, G.; Lebotlan, P.; Leconte, A.; Lelandais, J.; Mosrin, P.; Munsch, P.; Saur, H.; Tillier, J.

    1998-01-01

    The reports presents the main results obtained in the fields of radiation detectors and associated electronics. In the domain of X-ray gas detectors for the keV range efforts were undertaken to rise the detector efficiency. Multiple gap parallel plate chambers of different types as well as different types of X → e - converters were tested to improve the efficiency (values of 2.4% at 60 KeV were reached). In the field of scintillators a study of new crystals has been carried out (among which Lutetium orthosilicate). CdTe diode strips for obtaining X-ray imaging were studied. The complete study of a linear array of 8 CdTe pixels has been performed and certified. The results are encouraging and point to this method as a satisfying solution. Also, a large dimension programmable chamber was used to study the influence of temperature on the inorganic scintillators in an interval from -40 deg. C to +150 deg. C. Temperature effects on other detectors and electronic circuits were also investigated. In the report mentioned is also the work carried out for the realization of the DEMON neutron multidetector. For neutron halo experiments different large area Si detectors associated with solid and gas position detectors were realized. In the frame of a contract with COGEMA a systematic study of Li doped glasses was undertaken aiming at replacing with a neutron probe the 3 He counters presently utilized in pollution monitoring. An industrial prototype has been realised. Other studies were related to integrated analog chains, materials for Cherenkov detectors, scintillation probes for experiments on fundamental processes, gas position sensitive detectors, etc. In the field of associated electronics there are mentioned the works related to the multidetector INDRA, data acquisition, software gamma spectrometry, automatic gas pressure regulation in detectors, etc

  8. How to prevent ripening blockage in 1-MCP-treated 'Conference' pears.

    Science.gov (United States)

    Chiriboga, Maria-Angeles; Schotsmans, Wendy C; Larrigaudière, Christian; Dupille, Eve; Recasens, Inmaculada

    2011-08-15

    Some European pear varieties treated with 1-methylcyclopropene (1-MCP) often remain 'evergreen', meaning that their ripening process is blocked and does not resume after removal from cold storage. In this work this was confirmed also to be the case in 'Conference' pears. To reverse the blockage of ripening 1-MCP treatments combined with external exogenous ethylene were tested. 1-MCP treatment of 'Conference' pears is very effective in delaying ripening and, more specifically, softening. The same 1-MCP concentration in different experimental years caused a different response. The higher dose of 1-MCP (600 nL L⁻¹) always resulted in irreversible blockage of ripening, whereas the behaviour of fruit receiving a lower dose (300 nL L⁻¹) depended on the year, and this did not depend on maturity at harvest or on storage conditions. Simultaneous exposure to 1-MCP and exogenous ethylene significantly affected fruit ripening, allowing significant softening to occur but at a lower rate compared with control fruit. The application of exogenous ethylene and 1-MCP simultaneously after harvest permitted restoration of the ripening process after storage in 'Conference' pears, extending the possibility of marketing and consumption. Copyright © 2011 Society of Chemical Industry.

  9. The Belle II imaging Time-of-Propagation (iTOP) detector

    Science.gov (United States)

    Fast, J.; Belle II Barrel Particle Identification Group

    2017-12-01

    High precision flavor physics measurements are an essential complement to the direct searches for new physics at the LHC ATLAS and CMS experiments. Such measurements will be performed using the upgraded Belle II detector that will take data at the SuperKEKB accelerator. With 40x the luminosity of KEKB, the detector systems must operate efficiently at much higher rates than the original Belle detector. A central element of the upgrade is the barrel particle identification system. Belle II has built and installed an imaging-Time-of-Propagation (iTOP) detector. The iTOP uses quartz optics as Cherenkov radiators. The photons are transported down the quartz bars via total internal reflection with a spherical mirror at the forward end to reflect photons to the backward end where they are imaged onto an array of segmented Micro-Channel Plate Photo-Multiplier Tubes (MCP-PMTs). The system is read out using giga-samples per second waveform sampling Application-Specific Integrated Circuits (ASICs). The combined timing and spatial distribution of the photons for each event are used to determine particle species. This paper provides an overview of the iTOP system.

  10. IP-10, MCP-1, MCP-2, MCP-3, and IL-1RA hold promise as biomarkers for infection with M. tuberculosis in a whole blood based T-cell assay

    DEFF Research Database (Denmark)

    Ruhwald, Morten; Bjerregaard-Andersen, Morten; Rabna, Paulo

    2009-01-01

    and mitogen in the Quantiferon In Tube test tubes. Levels of biomarkers were measured using Luminex and ELISA (IFN-gamma). RESULTS: We found all five new biomarkers were expressed in significantly higher concentrations compared to IFN-gamma. IP-10 and MCP-3 levels in the un-stimulated samples were higher...

  11. Development of sub-nanosecond, high gain structures for time-of-flight ring imaging in large area detectors

    International Nuclear Information System (INIS)

    Wetstein, Matthew

    2011-01-01

    Microchannel plate photomultiplier tubes (MCPs) are compact, imaging detectors, capable of micron-level spatial imaging and timing measurements with resolutions below 10 ps. Conventional fabrication methods are too expensive for making MCPs in the quantities and sizes necessary for typical HEP applications, such as time-of-flight ring-imaging Cherenkov detectors (TOF-RICH) or water Cherenkov-based neutrino experiments. The Large Area Picosecond Photodetector Collaboration (LAPPD) is developing new, commercializable methods to fabricate 20 cm 2 thin planar MCPs at costs comparable to those of traditional photo-multiplier tubes. Transmission-line readout with waveform sampling on both ends of each line allows the efficient coverage of large areas while maintaining excellent time and space resolution. Rather than fabricating channel plates from active, high secondary electron emission materials, we produce plates from passive substrates, and coat them using atomic layer deposition (ALD), a well established industrial batch process. In addition to possible reductions in cost and conditioning time, this allows greater control to optimize the composition of active materials for performance. We present details of the MCP fabrication method, preliminary results from testing and characterization facilities, and possible HEP applications.

  12. Relationships between serum MCP-1 and subclinical kidney disease: African American-Diabetes Heart Study

    Directory of Open Access Journals (Sweden)

    Murea Mariana

    2012-11-01

    Full Text Available Abstract Background Monocyte chemoattractant protein-1 (MCP-1 plays important roles in kidney disease susceptibility and atherogenesis in experimental models. Relationships between serum MCP-1 concentration and early nephropathy and subclinical cardiovascular disease (CVD were assessed in African Americans (AAs with type 2 diabetes (T2D. Methods Serum MCP-1 concentration, urine albumin:creatinine ratio (ACR, estimated glomerular filtration rate (eGFR, and atherosclerotic calcified plaque (CP in the coronary and carotid arteries and infrarenal aorta were measured in 479 unrelated AAs with T2D. Generalized linear models were fitted to test for associations between MCP-1 and urine ACR, eGFR, and CP. Results Participants were 57% female, with mean ± SD (median age 55.6±9.5 (55.0 years, diabetes duration 10.3±8.2 (8.0 years, urine ACR 149.7±566.7 (14.0 mg/g, CKD-EPI eGFR 92.4±23.3 (92.0 ml/min/1.73m2, MCP-1 262.9±239.1 (224.4 pg/ml, coronary artery CP 280.1±633.8 (13.5, carotid artery CP 47.1±132.9 (0, and aorta CP 1616.0±2864.0 (319.0. Adjusting for age, sex, smoking, HbA1c, BMI, and LDL, serum MCP-1 was positively associated with albuminuria (parameter estimate 0.0021, P=0.04 and negatively associated with eGFR (parameter estimate −0.0003, P=0.001. MCP-1 remained associated with eGFR after adjustment for urine ACR. MCP-1 levels did not correlate with the extent of CP in any vascular bed, HbA1c or diabetes duration, but were positively associated with BMI. No interaction between BMI and MCP-1 was detected on nephropathy outcomes. Conclusions Serum MCP-1 levels are associated with eGFR and albuminuria in AAs with T2D. MCP-1 was not associated with subclinical CVD in this population. Inflammation appears to play important roles in development and/or progression of kidney disease in AAs.

  13. Detection, Quantification, and Microlocalisation of Targets of Pesticides Using Microchannel Plate Autoradiographic Imagers

    Directory of Open Access Journals (Sweden)

    Mabruka H. Tarhoni

    2011-10-01

    Full Text Available Organophosphorus (OP compounds are a diverse chemical group that includes nerve agents and pesticides. They share a common chemical signature that facilitates their binding and adduction of acetylcholinesterase (AChE within nerve synapses to induce cholinergic toxicity. However, this group diversity results in non-uniform binding and inactivation of other secondary protein targets, some of which may be adducted and protein activity influenced, even when only a relatively minor portion of tissue AChE is inhibited. The determination of individual OP protein binding targets has been hampered by the sensitivity of methods of detection and quantification of protein-pesticide adducts. We have overcome this limitation by the employment of a microchannel plate (MCP autoradiographic detector to monitor a radiolabelled OP tracer compound. We preincubated rat thymus tissue in vitro with the OP pesticides, azamethiphos-oxon, chlorfenvinphos-oxon, chlorpyrifos-oxon, diazinon-oxon, and malaoxon, and then subsequently radiolabelled the free OP binding sites remaining with 3H-diisopropylfluorophosphate (3H-DFP. Proteins adducted by OP pesticides were detected as a reduction in 3H-DFP radiolabelling after protein separation by one dimensional polyacrylamide gel electrophoresis and quantitative digital autoradiography using the MCP imager. Thymus tissue proteins of molecular weights ~28 kDa, 59 kDa, 66 kDa, and 82 kDa displayed responsiveness to adduction by this panel of pesticides. The 59 kDa protein target (previously putatively identified as carboxylesterase I was only significantly adducted by chlorfenvinphos-oxon (p < 0.001, chlorpyrifos-oxon (p < 0.0001, and diazinon-oxon (p < 0.01, the 66 kDa protein target (previously identified as serum albumin similarly only adducted by the same three pesticides (p < 0.0001, (p < 0.001, and (p < 0.01, and the 82 kDa protein target (previously identified as acyl peptide hydrolase only adducted by chlorpyrifos-oxon (p

  14. MCP-1 in urine as biomarker of disease activity in Systemic Lupus Erythematosus.

    Science.gov (United States)

    Barbado, Julia; Martin, Debora; Vega, Luisa; Almansa, Raquel; Gonçalves, Lisbeth; Nocito, Mercedes; Jimeno, Antonio; Ortiz de Lejarazu, Raúl; Bermejo-Martin, Jesus F

    2012-11-01

    Conventional clinical parameters are not sensitive or specific enough for detecting ongoing disease activity in the Systemic Lupus Erythematosus (SLE). Measurement of cytokines in urine is an encouraging approach to detection of early flares in this disease. Here we have profiled 27 different cytokines, chemokines and celular growth factors in the urine of 48 patients previously diagnosed of SLE as potential biomarkers of disease activity. Correlation analysis with Bonferroni correction showed that MCP-1 was the only immune mediator which levels in urine correlated directly with the SLE Disease Activity Index 2000 (SLEDAI-2K) score (correlation coefficient, p): MCP-1 (0.45,0.003). MCP-1 correlated inversely with levels of C3 complement protein in serum (-0.50,0.001). MCP-1 showed significant higher levels in patients with severe disease activity in comparison with those exhibiting mild activity. Levels of this chemokine were also higher in patients with severe disease activity in comparison with patients with inactive disease and healthy controls. Areas under receiver operating characteristic curves (AUROC) for detection of severe disease (SLEDAI⩾8) was as follows for MCP-1: [AUROC, (IC95%), p]: [0.81 (0.65-0.96) 0.003]. In addition, MCP-1 showed a good result in the AUROC analysis for detecting renal involvement [0.70 (0.52-0.87) 0.050]. When correlation analysis were repeated excluding those patients with active renal disease (n=14), levels of MCP-1 in urine kept on showing a significant positive association with SLEDAI-2K score. In conclusion, multiplex-based cytokine profiling in urine demonstrated the superiority of MCP-1 over a wide range of cytokines as biomarker of disease activity in SLE. Copyright © 2012 Elsevier Ltd. All rights reserved.

  15. 1-MCP pretreatment prevents bud and flower abscission in Dendrobium orchids

    NARCIS (Netherlands)

    Uthaichay, N.; Ketsa, S.; Doorn, van W.G.

    2007-01-01

    Dendrobium orchid inflorescences were treated for 4 h at 25 °C with or without 100¿500 nl/l 1-MCP and were then placed in water at 25 °C to follow abscission. In controls, depending on the experiment, 20¿80% of the floral buds and 0¿20% of the open flowers abscised within 1 week. The 1-MCP

  16. Amorphous silicon-based microchannel plates

    International Nuclear Information System (INIS)

    Franco, Andrea; Riesen, Yannick; Wyrsch, Nicolas; Dunand, Sylvain; Powolny, François; Jarron, Pierre; Ballif, Christophe

    2012-01-01

    Microchannel plates (MCP) based on hydrogenated amorphous silicon (a-Si:H) were recently introduced to overcome some of the limitations of crystalline silicon and glass MCP. The typical thickness of a-Si:H based MCPs (AMCP) ranges between 80 and 100 μm and the micromachining of the channels is realized by deep reactive ion etching (DRIE). Advantages and issues regarding the fabrication process are presented and discussed. Electron amplification is demonstrated and analyzed using Electron Beam Induced Current (EBIC) technique. The gain increases as a function of the bias voltage, limited to −340 V on account of high leakage currents across the structure. EBIC maps on 10° tilted samples confirm that the device active area extend to the entire channel opening. AMCP characterization with the electron beam shows gain saturation and signal quenching which depends on the effectiveness of the charge replenishment in the channel walls.

  17. Anti-inflammatory effect of resveratrol on TNF-α-induced MCP-1 expression in adipocytes

    International Nuclear Information System (INIS)

    Zhu Jian; Yong Wei; Wu Xiaohong; Yu Ying; Lv Jinghuan; Liu Cuiping; Mao Xiaodong; Zhu Yunxia; Xu Kuanfeng; Han Xiao; Liu Chao

    2008-01-01

    Chronic low-grade inflammation characterized by adipose tissue macrophage accumulation and abnormal cytokine production is a key feature of obesity and type 2 diabetes. Adipose-tissue-derived monocyte chemoattractant protein (MCP)-1, induced by cytokines, has been shown to play an essential role in the early events during macrophage infiltration into adipose tissue. In this study we investigated the effects of resveratrol upon both tumor necrosis factor (TNF)-α-induced MCP-1 gene expression and its underlying signaling pathways in 3T3-L1 adipoctyes. Resveratrol was found to inhibit TNF-α-induced MCP-1 secretion and gene transcription, as well as promoter activity, which based on down-regulation of TNF-α-induced MCP-1 transcription. Nuclear factor (NF)-κB was determined to play a major role in the TNF-α-induced MCP-1 expression. Further analysis showed that resveratrol inhibited DNA binding activity of the NF-κB complex and subsequently suppressed NF-κB transcriptional activity in TNF-α-stimulated cells. Finally, the inhibition of MCP-1 may represent a novel mechanism of resveratrol in preventing obesity-related pathologies

  18. Melanocyte pigmentation inversely correlates with MCP-1 production and angiogenesis-inducing potential.

    Science.gov (United States)

    Adini, Irit; Adini, Avner; Bazinet, Lauren; Watnick, Randolph S; Bielenberg, Diane R; D'Amato, Robert J

    2015-02-01

    The incidence of certain angiogenesis-dependent diseases is higher in Caucasians than in African Americans. Angiogenesis is amplified in wound healing and cornea models in albino C57 mice compared with black C57 mice. Moreover, mouse and human melanocytes with low pigmentation stimulate endothelial cell (EC) proliferation and migration in vitro more than melanocytes with high pigmentation. This effect is due, in part, to the secretion of an angiogenic protein called fibromodulin (FMOD) from lowly pigmented melanocytes. Herein, we expand upon the mechanism contributing to increased angiogenesis in lighter skin and report that monocyte chemotactic protein-1 (MCP-1) is secreted by nonpigmented mouse melanocytes by 5- to 10-fold more than pigmented melanocytes. MCP-1 protein stimulates EC proliferation and migration in vitro and angiogenesis in vivo. Mechanistic studies determine that FMOD is upstream of MCP-1 and promotes its secretion from both melanocytes and activated ECs via stimulation of NF-κB activity. Mice injected with FMOD-neutralizing antibodies show 2.3-fold decreased levels of circulating MCP-1. Human studies confirmed that, on average, Caucasians have 2-fold higher serum levels of MCP-1 than African Americans. Taken together, this study implicates the FMOD/MCP-1 pathway in the regulation of angiogenesis by local melanocytes and suggests that melanogenic activity may protect against aberrant angiogenic diseases. © FASEB.

  19. Cold plate

    Energy Technology Data Exchange (ETDEWEB)

    Marroquin, Christopher M.; O' Connell, Kevin M.; Schultz, Mark D.; Tian, Shurong

    2018-02-13

    A cold plate, an electronic assembly including a cold plate, and a method for forming a cold plate are provided. The cold plate includes an interface plate and an opposing plate that form a plenum. The cold plate includes a plurality of active areas arranged for alignment over respective heat generating portions of an electronic assembly, and non-active areas between the active areas. A cooling fluid flows through the plenum. The plenum, at the non-active areas, has a reduced width and/or reduced height relative to the plenum at the active areas. The reduced width and/or height of the plenum, and exterior dimensions of cold plate, at the non-active areas allow the non-active areas to flex to accommodate surface variations of the electronics assembly. The reduced width and/or height non-active areas can be specifically shaped to fit between physical features of the electronics assembly.

  20. Plating laboratory

    International Nuclear Information System (INIS)

    Seamster, A.G.; Weitkamp, W.G.

    1984-01-01

    The lead plating of the prototype resonator has been conducted entirely in the plating laboratory at SUNY Stony Brook. Because of the considerable cost and inconvenience in transporting personnel and materials to and from Stony Brook, it is clearly impractical to plate all the resonators there. Furthermore, the high-beta resonator cannot be accommodated at Stony Brook without modifying the set up there. Consequently the authors are constructing a plating lab in-house

  1. The parameterization of microchannel-plate-based detection systems

    Science.gov (United States)

    Gershman, Daniel J.; Gliese, Ulrik; Dorelli, John C.; Avanov, Levon A.; Barrie, Alexander C.; Chornay, Dennis J.; MacDonald, Elizabeth A.; Holland, Matthew P.; Giles, Barbara L.; Pollock, Craig J.

    2016-10-01

    The most common instrument for low-energy plasmas consists of a top-hat electrostatic analyzer (ESA) geometry coupled with a microchannel-plate-based (MCP-based) detection system. While the electrostatic optics for such sensors are readily simulated and parameterized during the laboratory calibration process, the detection system is often less well characterized. Here we develop a comprehensive mathematical description of particle detection systems. As a function of instrument azimuthal angle, we parameterize (1) particle scattering within the ESA and at the surface of the MCP, (2) the probability distribution of MCP gain for an incident particle, (3) electron charge cloud spreading between the MCP and anode board, and (4) capacitive coupling between adjacent discrete anodes. Using the Dual Electron Spectrometers on the Fast Plasma Investigation on NASA's Magnetospheric Multiscale mission as an example, we demonstrate a method for extracting these fundamental detection system parameters from laboratory calibration. We further show that parameters that will evolve in flight, namely, MCP gain, can be determined through application of this model to specifically tailored in-flight calibration activities. This methodology provides a robust characterization of sensor suite performance throughout mission lifetime. The model developed in this work is not only applicable to existing sensors but also can be used as an analytical design tool for future particle instrumentation.

  2. Observation of Ultra-Slow Antiprotons using Micro-channel Plate

    Science.gov (United States)

    Imao, H.; Torii, H. A.; Nagata, Y.; Toyoda, H.; Shimoyama, T.; Enomoto, Y.; Higaki, H.; Kanai, Y.; Mohri, A.; Yamazaki, Y.

    2008-08-01

    Our group ASACUSA-MUSASHI has succeeded in accumulating several million antiprotons and extracting them as monochromatic ultra-slow antiproton beams (10 eV-1 keV) at CERN AD. We have observed ultra-slow antiprotons using micro-channel plates (MCP). The integrated pulse area of the output signals generated when the MCP was irradiated by ultra-slow antiprotons was 6 times higher than that by electrons. As a long-term effect, we also observed an increase in the background rate presumably due to the radioactivation of the MCP surface. Irradiating the antiproton beams on the MCP induces antiproton-nuclear annihilations only on the first layer of the surface. Low-energy and short-range secondary particles like charged nuclear fragments caused by the "surface nuclear reactions" would be the origin of our observed phenomena.

  3. The Parameterization of Top-Hat Particle Sensors with Microchannel-Plate-Based Detection Systems and its Application to the Fast Plasma Investigation on NASA's Magnetospheric MultiScale Mission

    Science.gov (United States)

    Gershman, Daniel J.; Gliese, Ulrik; Dorelli, John C.; Avanov, Levon A.; Barrie, Alexander C.; Chornay, Dennis J.; MacDonald, Elizabeth A.; Holland, Matthew P.; Pollock, Craig J.

    2015-01-01

    The most common instrument for low energy plasmas consists of a top-hat electrostatic analyzer geometry coupled with a microchannel-plate (MCP)-based detection system. While the electrostatic optics for such sensors are readily simulated and parameterized during the laboratory calibration process, the detection system is often less well characterized. Furthermore, due to finite resources, for large sensor suites such as the Fast Plasma Investigation (FPI) on NASA's Magnetospheric Multiscale (MMS) mission, calibration data are increasingly sparse. Measurements must be interpolated and extrapolated to understand instrument behavior for untestable operating modes and yet sensor inter-calibration is critical to mission success. To characterize instruments from a minimal set of parameters we have developed the first comprehensive mathematical description of both sensor electrostatic optics and particle detection systems. We include effects of MCP efficiency, gain, scattering, capacitive crosstalk, and charge cloud spreading at the detector output. Our parameterization enables the interpolation and extrapolation of instrument response to all relevant particle energies, detector high voltage settings, and polar angles from a small set of calibration data. We apply this model to the 32 sensor heads in the Dual Electron Sensor (DES) and 32 sensor heads in the Dual Ion Sensor (DIS) instruments on the 4 MMS observatories and use least squares fitting of calibration data to extract all key instrument parameters. Parameters that will evolve in flight, namely MCP gain, will be determined daily through application of this model to specifically tailored in-flight calibration activities, providing a robust characterization of sensor suite performance throughout mission lifetime. Beyond FPI, our model provides a valuable framework for the simulation and evaluation of future detection system designs and can be used to maximize instrument understanding with minimal calibration

  4. A mechanistic modelling approach to understand 1-MCP inhibition of ethylene action and quality changes during ripening of apples.

    Science.gov (United States)

    Gwanpua, Sunny George; Verlinden, Bert E; Hertog, Maarten Latm; Nicolai, Bart M; Geeraerd, Annemie H

    2017-08-01

    1-Methylcyclopropene (1-MCP) inhibits ripening in climacteric fruit by blocking ethylene receptors, preventing ethylene from binding and eliciting its action. The objective of the current study was to use mathematical models to describe 1-MCP inhibition of apple fruit ripening, and to provide a tool for predicting ethylene production, and two important quality indicators of apple fruit, firmness and background colour. A model consisting of coupled differential equations describing 1-MCP inhibition of apple ripening was developed. Data on ethylene production, expression of ethylene receptors, firmness, and background colour during ripening of untreated and 1-MCP treated apples were used to calibrate the model. An overall adjusted R 2 of 95% was obtained. The impact of time from harvest to treatment, and harvest maturity on 1-MCP efficacy was modelled. Different hypotheses on the partial response of 'Jonagold' apple to 1-MCP treatment were tested using the model. The model was validated using an independent dataset. Low 1-MCP blocking efficacy was shown to be the most likely cause of partial response for delayed 1-MCP treatment, and 1-MCP treatment of late-picked apples. Time from harvest to treatment was a more important factor than maturity for 1-MCP efficacy in 'Jonagold' apples. © 2017 Society of Chemical Industry. © 2017 Society of Chemical Industry.

  5. Monocyte chemoattractant protein-1 (MCP-1 regulates macrophage cytotoxicity in abdominal aortic aneurysm.

    Directory of Open Access Journals (Sweden)

    Qiwei Wang

    Full Text Available AIMS: In abdominal aortic aneurysm (AAA, macrophages are detected in the proximity of aortic smooth muscle cells (SMCs. We have previously demonstrated in a murine model of AAA that apoptotic SMCs attract monocytes and other leukocytes by producing MCP-1. Here we tested whether infiltrating macrophages also directly contribute to SMC apoptosis. METHODS AND RESULTS: Using a SMC/RAW264.7 macrophage co-culture system, we demonstrated that MCP-1-primed RAWs caused a significantly higher level of apoptosis in SMCs as compared to control macrophages. Next, we detected an enhanced Fas ligand (FasL mRNA level and membrane FasL protein expression in MCP-1-primed RAWs. Neutralizing FasL blocked SMC apoptosis in the co-culture. In situ proximity ligation assay showed that SMCs exposed to primed macrophages contained higher levels of receptor interacting protein-1 (RIP1/Caspase 8 containing cell death complexes. Silencing RIP1 conferred apoptosis resistance to SMCs. In the mouse elastase injury model of aneurysm, aneurysm induction increased the level of RIP1/Caspase 8 containing complexes in medial SMCs. Moreover, TUNEL-positive SMCs in aneurysmal tissues were frequently surrounded by CD68(+/FasL(+ macrophages. Conversely, elastase-treated arteries from MCP-1 knockout mice display a reduction of both macrophage infiltration and FasL expression, which was accompanied by diminished apoptosis of SMCs. CONCLUSION: Our data suggest that MCP-1-primed macrophages are more cytotoxic. MCP-1 appears to modulate macrophage cytotoxicity by increasing the level of membrane bound FasL. Thus, we showed that MCP-1-primed macrophages kill SMCs through a FasL/Fas-Caspase8-RIP1 mediated mechanism.

  6. Investigation of a Multi-Anode Microchannel Plate PMT for Time-of-Flight PET

    Science.gov (United States)

    Choong, Woon-Seng

    2010-10-01

    We report on an investigation of a mulit-anode microchannel plate PMT for time-of-flight PET detector modules. The primary advantages of an MCP lie in its excellent timing properties (fast rise time and low transit time spread), compact size, and reasonably large active area, thus making it a good candidate for TOF applications. In addition, the anode can be segmented into an array of collection electrodes with fine pitch to attain good position sensitivity. In this paper, we investigate using the Photonis Planacon MCP-PMT with a pore size of 10 μm to construct a PET detector module, specifically for time-of-flight applications. We measure the single electron response by exciting the Planacon with pulsed laser diode. We also measure the performance of the Planacon as a PET detector by coupling a 4 mm×4 mm×10 mm LSO crystal to individual pixel to study its gain uniformity, energy resolution, and timing resolution. The rise time of the Planacon is 440 ps with pulse duration of about 1 ns. A transit time spread of 120 ps FWHM is achieved. The gain is fairly uniform across the central region of the Planacon, but drops off by as much as a factor of 2.5 around the edges. The energy resolution is fairly uniform across the Planacon with an average value of 18.6 ± 0.7% FWHM. While the average timing resolution of 252 ± 7 ps FWHM is achieved in the central region of the Planacon, it degrades to 280 ± 9 ps FWHM for edge pixels and 316 ± 15 ps FWHM for corner pixels. We compare the results with measurements performed with a fast timing conventional PMT (Hamamatsu R-9800). We find that the R9800, which has significantly higher PDE, has a better timing resolution than the Planacon. Furthermore, we perform detector simulations to calculate the improvement that can be achieved with a higher PDE Planacon. The calculation shows that the Planacon can achieve significantly better timing resolution if it can attain the same PDE as the R-9800, while only a 30% improvement is

  7. Ionization detector

    Energy Technology Data Exchange (ETDEWEB)

    Solomon, E E

    1976-02-27

    This invention concerns a fire detection system making use of a beta source. The ionisation detector includes a first and second chamber respectively comprising a first and second electrode, preferably a plate, with a common electrode separating the first and second chamber. Communication is provided between these chambers through a set of orifices and each chamber also has a set of orifices for communication with the ambient atmosphere. One or both chambers can comprise a particle source, preferably beta. The detector also has an adjustable electrode housed in one of the chambers to regulate the voltage between the fixed electrode of this chamber and the common electrode located between the chambers. The electrodes of the structure are connected to a detection circuit that spots a change in the ionisation current when a fire alarm condition arises. The detection circuit of a new type includes a relaxation oscillator with a programmable unijunction transistor and a light emitting diode.

  8. TORCH: A Large-Area Detector for Precision Time-of-Flight Measurements at LHCb

    CERN Document Server

    Harnew, N

    2012-01-01

    The TORCH (Time Of internally Reflected CHerenkov light) is an innovative high-precision time-of-flight detector which is suitable for large areas, up to tens of square metres, and is being developed for the upgraded LHCb experiment. The TORCH provides a time-of-flight measurement from the imaging of photons emitted in a 1 cm thick quartz radiator, based on the Cherenkov principle. The photons propagate by total internal reflection to the edge of the quartz plane and are then focused onto an array of Micro-Channel Plate (MCP) photon detectors at the periphery of the detector. The goal is to achieve a timing resolution of 15 ps per particle over a flight distance of 10 m. This will allow particle identification in the challenging momentum region up to 20 GeV/c. Commercial MCPs have been tested in the laboratory and demonstrate the required timing precision. An electronics readout system based on the NINO and HPTDC chipset is being developed to evaluate an 8×8 channel TORCH prototype. The simulated performance...

  9. Thioredoxin reductase 1 upregulates MCP-1 release in human endothelial cells

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Zhen-Bo [Institute of Biophysics, Chinese Academy of Sciences, and Graduate School of the Chinese Academy of Sciences, Beijing (China); Shen, Xun, E-mail: shenxun@sun5.ibp.ac.cn [Institute of Biophysics, Chinese Academy of Sciences, and Graduate School of the Chinese Academy of Sciences, Beijing (China)

    2009-09-04

    To know if thioredoxin reductase 1 (TrxR1) plays a role in antioxidant defense mechanisms against atherosclerosis, effect of TrxR1 on expression/release of monocyte chemoattractant protein (MCP-1) was investigated in activated human endothelial-like EAhy926 cells. The MCP-1 release and expression, cellular generation of reactive oxygen species (ROS), nuclear translocation and DNA-binding activity of NF-{kappa}B subunit p65 were assayed in cells either overexpressing recombinant TrxR1 or having their endogenous TrxR1 knocked down. It was found that overexpression of TrxR1 enhanced, while knockdown of TrxR1 reduced MCP-1 release and expression. Upregulation of MCP-1 by TrxR1 was associated with increasing generation of intracellular ROS generation, enhanced nuclear translocation and DNA-binding activity of NF-{kappa}B. Assay using NF-{kappa}B reporter revealed that TrxR1 upregulated transcriptional activity of NF-{kappa}B. This study suggests that TrxR1 enhances ROS generation, NF-{kappa}B activity and subsequent MCP-1 expression in endothelial cells, and may promote rather than prevent vascular endothelium from forming atherosclerotic plaque.

  10. IL-8 and MCP Gene Expression and Production by LPS-Stimulated Human Corneal Stromal Cells

    Directory of Open Access Journals (Sweden)

    Roni M. Shtein

    2012-01-01

    Full Text Available Purpose. To determine time course of effect of lipopolysaccharide (LPS on production of interleukin-8 (IL-8 and monocyte chemotactic protein (MCP by cultured human corneal stromal cells. Methods. Human corneal stromal cells were harvested from donor corneal specimens, and fourth to sixth passaged cells were used. Cell cultures were stimulated with LPS for 2, 4, 8, and 24 hours. Northern blot analysis of IL-8 and MCP gene expression and ELISA for IL-8 and MCP secretion were performed. ELISA results were analyzed for statistical significance using two-tailed Student's t-test. Results. Northern blot analysis demonstrated significantly increased IL-8 and MCP gene expression after 4 and 8 hours of exposure to LPS. ELISA for secreted IL-8 and MCP demonstrated statistically significant increases (P<0.05 after corneal stromal cell stimulation with LPS. Conclusions. This paper suggests that human corneal stromal cells may participate in corneal inflammation by secreting potent leukocyte chemotactic and activating proteins in a time-dependent manner when exposed to LPS.

  11. Fabrication of resistive plate chamber using bakelite

    International Nuclear Information System (INIS)

    Neog, Himangshu; Bhuyan, M.R.; Biswas, S.; Mohanty, B.; Mohanty, Rudranarayan; Rudra, Sharmili; Sahu, P.K.; Sahu, S.

    2014-01-01

    Now a days Resistive Plate Chamber (RPC) is one of the most important detectors in the High Energy Physics (HEP) experiments. RPC is a gas filled detector utilizing a constant and uniform electric field produced between two parallel electrode plates made of a material with high bulk resistivity e.g. glass or bakelite. RPC has good time resolution (1-2 ns) and spatial resolution (∼ cm). The high resistance of RPC plate limits the spark size produced after the ionization of gas due to the passing charged particle. This contribution discusses building of a RPC using bakelite (local sources) and the measurement of the surface resistivity of the detector

  12. Multicell x-ray detector

    International Nuclear Information System (INIS)

    Stone, B.N.; Shelley, P.S.; Love, W.D.

    1981-01-01

    This invention is concerned with improving multicell detectors, particularly those used in computerized tomography. Existing ionization detectors have problems maintaining the precise dimensional spacing between electrodes required for accuracy. In addition, mechanical vibrations set up microphonic effects between the electrode plates. In this invention, pairs of electrode plates are separated by grooved insulating members. The upper and lower edges of an array of electrode plates are inserted in corresponding grooves in the insulating members, and, the whole electrode assembly is securely anchored in the detector chamber

  13. JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain.

    Science.gov (United States)

    Gao, Yong-Jing; Zhang, Ling; Samad, Omar Abdel; Suter, Marc R; Yasuhiko, Kawasaki; Xu, Zhen-Zhong; Park, Jong-Yeon; Lind, Anne-Li; Ma, Qiufu; Ji, Ru-Rong

    2009-04-01

    Our previous study showed that activation of c-jun-N-terminal kinase (JNK) in spinal astrocytes plays an important role in neuropathic pain sensitization. We further investigated how JNK regulates neuropathic pain. In cultured astrocytes, tumor necrosis factor alpha (TNF-alpha) transiently activated JNK via TNF receptor-1. Cytokine array indicated that the chemokine CCL2/MCP-1 (monocyte chemoattractant protein-1) was strongly induced by the TNF-alpha/JNK pathway. MCP-1 upregulation by TNF-alpha was dose dependently inhibited by the JNK inhibitors SP600125 (anthra[1,9-cd]pyrazol-6(2H)-one) and D-JNKI-1. Spinal injection of TNF-alpha produced JNK-dependent pain hypersensitivity and MCP-1 upregulation in the spinal cord. Furthermore, spinal nerve ligation (SNL) induced persistent neuropathic pain and MCP-1 upregulation in the spinal cord, and both were suppressed by D-JNKI-1. Remarkably, MCP-1 was primarily induced in spinal cord astrocytes after SNL. Spinal administration of MCP-1 neutralizing antibody attenuated neuropathic pain. Conversely, spinal application of MCP-1 induced heat hyperalgesia and phosphorylation of extracellular signal-regulated kinase in superficial spinal cord dorsal horn neurons, indicative of central sensitization (hyperactivity of dorsal horn neurons). Patch-clamp recordings in lamina II neurons of isolated spinal cord slices showed that MCP-1 not only enhanced spontaneous EPSCs but also potentiated NMDA- and AMPA-induced currents. Finally, the MCP-1 receptor CCR2 was expressed in neurons and some non-neuronal cells in the spinal cord. Together, we have revealed a previously unknown mechanism of MCP-1 induction and action. MCP-1 induction in astrocytes after JNK activation contributes to central sensitization and neuropathic pain facilitation by enhancing excitatory synaptic transmission. Inhibition of the JNK/MCP-1 pathway may provide a new therapy for neuropathic pain management.

  14. CHANGES IN MECHANICAL PROPERTIES OF MINIMALLY-PROCESSED YELLOW PITAHAYA TREATED WITH 1-MCP

    Directory of Open Access Journals (Sweden)

    LILIANA SERNA COCK

    2012-01-01

    Full Text Available Se evaluaron las propiedades mecánicas de esfuerzo del límite de fluencia (sL, modulo de deformación (Ed, esfuerzo de ruptura (sF, y deformación de Hencky en la ruptura (eHF de muestras de pitahaya amarilla mínimamente procesada y tratadas con 200 μgL-1 de 1-MCP durante el almacenamiento a 10±1 °C y 85% de humedad relativa. Las muestras fueron sometidas a pruebas de compresión uniaxial hasta la ruptura. Los resultados mostraron que las muestras tratadas con 1-MCP presentaron los mayores valores del esfuerzo del límite de fluencia, modulo de elasticidad y esfuerzo de ruptura. Esto indica que la aplicación del 1-MCP proporciona mayor firmeza a la fruta y puede representar una alternativa para disminuir cambios indeseables de textura durante el almacenamiento.

  15. Impact of MCP-1 and CCR-2 gene polymorphisms on coronary artery disease susceptibility.

    Science.gov (United States)

    Lin, Hsiu-Ling; Ueng, Kwo-Chang; Hsieh, Yih-Shou; Chiang, Whei-Ling; Yang, Shun-Fa; Chu, Shu-Chen

    2012-09-01

    Coronary artery disease (CAD) was the second leading cause of death during the last 3 years in Taiwan. Smooth muscle cells, monocytes/macrophages, and endothelial cells produce monocyte chemoattractant protein-1 (MCP-1) within atherosclerotic plaques following binding to the chemokine receptor-2 (CCR-2). Previous studies have well-documented the association between MCP-1 expression and susceptibility to, or clinicopathological features, of CAD. This study investigated the relationships between MCP-1-2518A/G and CCR-2-V64I genetic polymorphisms and CAD in the Taiwanese population. A total of 608 subjects, including 392 non-CAD controls and 216 patients with CAD, were recruited and subjected to polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) to evaluate the effects of these two polymorphic variants on CAD. Results indicated a significant association between MCP-1 -2548 gene polymorphism and susceptibility to CAD. GG genotypes (OR = 1.629; 95 % CI = 1.003-2.644), or individuals with at least one G allele (OR = 1.511; 95 % CI = 1.006-2.270), had a higher risk of CAD as compared with AA genotypes. Results also revealed that subjects with at least one A allele of the V64I CCR2 gene polymorphism had significantly increased risk of CAD. G allele in MCP-1-2518 might contribute to higher prevalence of atrial fibrillation in CAD patients (OR = 4.254; p CCR-2 64I gene polymorphisms represent important factors in determining susceptibility to CAD, and the contribution of MCP-1-2518G could be through effects on atrial fibrillation in CAD patients.

  16. Solid state detector module

    International Nuclear Information System (INIS)

    Hoffman, D. M.

    1985-01-01

    A solid state detector in which each scintillator is optimally configured and coupled with its associated sensing diode in a way which exploits light piping effects to enhance efficiency, and at the same time provide a detector which is modular in nature. To achieve light piping, the scintillator crystal is oriented such that its sides conform with the crystal cleavage plane, and the sides are highly polished. An array of tungsten collimator plates define the individual channels. Multi-channel scintillator/diode modules are mounted behind and in registry with the plurality of collimator plates. A plurality of scintillators are bonded together after coating the surfaces thereof to minimize optical crosstalk. After lapping the face of the scintillator module, it is then bonded to a diode module with individual scintillators in registration with individual diodes. The module is then positioned in the detector array with collimator plates at the junctions between the scintillators

  17. MCP-1 Levels are Associated with Cardiac Remodeling but not with Resistant Hypertension.

    Science.gov (United States)

    Ritter, Alessandra Mileni Versuti; Faria, Ana Paula Cabral de; Sabbatini, Andrea; Corrêa, Nathalia Batista; Brunelli, Veridiana; Modolo, Rodrigo; Moreno, Heitor

    2017-04-01

    Hypertension is a chronic, low-grade inflammation process associated with the release of cytokines and development of target organ damage. Deregulated monocyte chemoattractant protein-1 (MCP-1) levels have been associated with high blood pressure and cardiovascular complications; however, the mechanisms involved are complex and not fully understood. This study aimed to compare the levels of MCP-1 in patients with resistant (RH) versus mild-to-moderate (HTN) hypertension and their association with the presence or absence of left ventricular hypertrophy (LVH) in all hypertensive subjects. We enrolled 256 hypertensive subjects: 120 RH and 136 HTN, investigating the relationship between circulating MCP-1 levels and blood pressure, biochemical data, hematologic profile, and cardiac damage within the RH and HTN groups. Plasma MCP-1 levels were measured by ELISA and LVH was assessed by echocardiography. We found no difference in MCP-1 levels between RH and HTN subjects. On the other hand, we encountered lower MCP-1 levels in patients with LVH (105 pg/mL [100 - 260 pg/mL] versus 136 pg/mL (100 - 200 pg/mL), p = 0.005, respectively] compared with those without LVH. A logistic regression model adjusted for body mass index (BMI), age, race, aldosterone levels, and presence of diabetes and RH demonstrated that median levels of MCP-1 (2.55 pg/mL [1.22 - 5.2 pg/mL], p = 0.01) were independently associated with LVH in the entire hypertensive population. Since MCP-1 levels were similar in both RH and HTN subjects and decreased in hypertensive patients with existing LVH, our study suggests a possible downregulation in MCP-1 levels in hypertensive individuals with LVH, regardless of hypertension strata. A hipertensão arterial é um processo crônico de baixo grau inflamatório, associado com liberação de citocinas e desenvolvimento de lesão em órgãos-alvo. A desregulação dos níveis de proteína quimiotática de monócitos-1 (MCP-1) tem sido associada com elevação da press

  18. MCP/CCR2 signaling is essential for recruitment of mesenchymal progenitor cells during the early phase of fracture healing.

    Directory of Open Access Journals (Sweden)

    Masahiro Ishikawa

    Full Text Available OBJECTIVE: The purpose of this study was to investigate chemokine profiles and their functional roles in the early phase of fracture healing in mouse models. METHODS: The expression profiles of chemokines were examined during fracture healing in wild-type (WT mice using a polymerase chain reaction array and histological staining. The functional effect of monocyte chemotactic protein-1 (MCP-1 on primary mouse bone marrow stromal cells (mBMSCs was evaluated using an in vitro migration assay. MCP-1-/- and C-C chemokine receptor 2 (CCR2-/- mice were fractured and evaluated by histological staining and micro-computed tomography (micro-CT. RS102895, an antagonist of CCR2, was continuously administered in WT mice before or after rib fracture and evaluated by histological staining and micro-CT. Bone graft exchange models were created in WT and MCP-1-/- mice and were evaluated by histological staining and micro-CT. RESULTS: MCP-1 and MCP-3 expression in the early phase of fracture healing were up-regulated, and high levels of MCP-1 and MCP-3 protein expression observed in the periosteum and endosteum in the same period. MCP-1, but not MCP-3, increased migration of mBMSCs in a dose-dependent manner. Fracture healing in MCP-1-/- and CCR2-/- mice was delayed compared with WT mice on day 21. Administration of RS102895 in the early, but not in the late phase, caused delayed fracture healing. Transplantation of WT-derived graft into host MCP-1-/- mice significantly increased new bone formation in the bone graft exchange models. Furthermore, marked induction of MCP-1 expression in the periosteum and endosteum was observed around the WT-derived graft in the host MCP-1-/- mouse. Conversely, transplantation of MCP-1-/- mouse-derived grafts into host WT mice markedly decreased new bone formation. CONCLUSIONS: MCP-1/CCR2 signaling in the periosteum and endosteum is essential for the recruitment of mesenchymal progenitor cells in the early phase of fracture healing.

  19. Neutron detector assembly

    International Nuclear Information System (INIS)

    Hanai, Koi; Shirayama, Shinpei.

    1978-01-01

    Purpose: To prevent gamma-ray from leaking externally passing through the inside of a neutron detector assembly. Constitution: In a neutron detector assembly having a protection pipe formed with an enlarged diameter portion which serves also as a spacer, partition plates with predetermined width are disposed at the upper and the lower portions in this expanded portion. A lot of metal particles are filled into spaces formed by the partition plates. In such a structure, the metal particles well-absorb the gamma-rays from above and convert them into heat to provide shielding for the gamma-rays. (Horiuchi, T.)

  20. New Electron Cloud Detectors for the PS Main Magnets

    CERN Document Server

    Yin Vallgren, Ch; Gilardoni, S; Taborelli, M; Neupert, H; Ferreira Somoza, J

    2014-01-01

    Electron cloud (EC) has already been observed during normal operation of the PS, therefore it is necessary to study its in fluence on any beam instability for the future LHC Injector Upgrade (LIU). Two new electron cloud detectors have been discussed, developed and installed during the Long Shutdown (LS1) in one of the PS main magnets. The first measurement method is based on current measurement by using a shielded button-type pick-up. Due to the geometry and space limitation in the PS magnet, the button-type pick-up made of a 96%Al2O3 block coated with a thin layer of solvent-based Ag painting, placed 30 degrees to the bottom part of the vacuum chamber was installed in the horizontal direction where the only opening of the magnet coil is. The other newly developed measurement method is based on detection of photons emitted by the electrons from the electron cloud impinging on the vacuum chamber walls. The emitted photons are reected to a quartz window. A MCP-PMT (Micro-Channel Plate Photomultiplier Tube) wit...

  1. Radon daughter plate-out onto Teflon

    Science.gov (United States)

    Morrison, E. S.; Frels, T.; Miller, E. H.; Schnee, R. W.; Street, J.

    2018-01-01

    Radiopure materials for detector components in rare event searches may be contaminated after manufacturing with long-lived 210Pb produced by the decay of atmospheric radon. Charged radon daughters deposited on the surface or implanted in the bulk of detector materials have the potential to cause noticeable backgrounds within dark matter regions of interest. Understanding the mechanics governing these background signals is therefore a paramount concern in dark matter experiments in order to distinguish a real signal from internal detector backgrounds. Teflon (i.e. PTFE) is a specific material of interest because it makes up the walls of the inner detector of many liquid noble detectors such as the LUX-ZEPLIN experiment. The rate of radon daughter plate-out onto Teflon can be orders of magnitude larger than the plate-out rate onto other materials. Mitigation of plate-out onto Teflon and steel by proximity to other materials is demonstrated.

  2. Electromagnetic disturbance neutralizing radiation detector

    International Nuclear Information System (INIS)

    Gripentog, W.G.

    1975-01-01

    A radiation detector of the Neher-White type is described which automatically neutralizes induced negative charges on the electrometer tube control grid which shut off the electrometer tube. The detector includes means for establishing a voltage of one polarity in response to plate current and voltage of opposite polarity in response to an absence of plate current and means for connecting the control grid to a reference potential for draining the negative charge in response to the voltage of opposite polarity. (author)

  3. Use of equimolar cysteine/ascorbic acids to recover MCP synthesized Ti(Mg) alloy

    CSIR Research Space (South Africa)

    Mushove, T

    2010-10-01

    Full Text Available Dissolution of waste by-products of mechanochemical processing (MCP) synthesis of Ti(Mg) alloy, from TiO2 and 15 wt.% excess Mg, was conducted in equimolar cysteine/ascorbic acids. The synthesized alloy is inherently mixed with MgO and other oxides...

  4. 'Diffuse skin browning' in 1-MCP-treated apples: etiology and systems of control.

    Science.gov (United States)

    Larrigaudière, Christian; Vilaplana, Rosa; Recasens, Inmaculada; Soria, Yolanda; Dupille, Eve

    2010-11-01

    'Diffuse skin browning' (DSB) is a physiological disorder that affects Golden Delicious apples treated with 1-methylcyclopropene (1-MCP). Although a very high incidence is found, very little is known about the etiology of this disorder. This study aims to provide an understanding of the causes of this disorder and prevent it. A very high incidence of DSB was found in 1-MCP-treated apples independent of the location of the orchard. Similar to superficial scald, harvest maturity determines the DSB incidence, with the more mature fruit being less sensitive. The 1-MCP dose (156 nL L(-1) or 625 nL L(-1)) and the temperature at which the 1-MCP treatment was applied (0.5 or 20 °C) did not affect the incidence of DSB. Diphenylamine (DPA) treatment did not prevent DSB, contrary to superficial scald. Additionally, controlled atmosphere storage only partially reduced the incidence of DSB, whereas progressive cooling strategies completely inhibited DSB occurrence. A direct correlation was found between the sensitivity of the Golden Delicious clone to russeting and its sensitivity to develop DSB during storage. Our results indicated that DSB and superficial scald are two different disorders involving different oxidative processes. DSB can be prevented by progressive cooling and selection of russeting-resistant clones. 2010 Society of Chemical Industry

  5. Influence of 1-MCP treatments on eating quality and consumer preferences of ‘Qinmei’ kiwifruit during shelf life

    Science.gov (United States)

    Consumers and growers in China sometime complain that Kiwifruits treated with an ethylene action inhibitor 1-MCP are difficult to ripen and show poor eating quality. This study addresses the quality parameters affecting consumer preferences and reevaluates the necessity of 1-MCP application for stor...

  6. Inexpensive read-out for coincident electron spectroscopy with a transmission electron microscope at nanometer scale using micro channel plates and multistrip anodes

    International Nuclear Information System (INIS)

    Hollander, R.W.; Bom, V.R.; Van Eijk, C.W.E.; Faber, J.S.; Hoevers, H.; Kruit, P.

    1994-01-01

    The elemental composition of a sample at nanometer scale is determined by measurement of the characteristic energy of Auger electrons, emitted in coincidence with incoming primary electrons from a microbeam in a scanning transmission electron microscope (STEM). Single electrons are detected with position sensitive detectors, consisting of MicroChannel Plates (MCP) and MultiStrip Anodes (MSA), one for the energy of the Auger electrons (Auger-detector) and one for the energy loss of primary electrons (EELS-detector). The MSAs are sensed with LeCroy 2735DC preamplifiers. The fast readout is based on LeCroy's PCOS III system. On the detection of a coincidence (Event) energy data of Auger and EELS are combined with timing data to an Event word. Event words are stored in list mode in a VME memory module. Blocks of Event words are scanned by transputers in VME and two-dimensional energy histograms are filled using the timing information to obtain a maximal true/accidental ratio. The resulting histograms are stored on disk of a PC-386, which also controls data taking. The system is designed to handle 10 5 Events per second, 90% of which are accidental. In the histograms the ''true'' to ''accidental'' ratio will be 5. The dead time is 15%. ((orig.))

  7. Particle localization detector

    International Nuclear Information System (INIS)

    Allemand, R.

    1976-01-01

    A proportional detector for the localization of particles comprises a leak-tight chamber filled with fluid and fitted with an electrode of a first type consisting of one or more conducting wires and with an electrode of a second type consisting of one or more conducting plates having the shape of a portion of cylindrical surface and a contour which provides a one-to-one correspondence between the position of a point of the wires and the solid angle which subtends the plate at that point, means being provided for collecting the electrical signal which appears on the plates. 12 Claims, 10 Drawing Figures

  8. Radiation detectors

    International Nuclear Information System (INIS)

    2013-01-01

    This sixth chapter presents the operational principles of the radiation detectors; detection using photographic emulsions; thermoluminescent detectors; gas detectors; scintillation detectors; liquid scintillation detectors; detectors using semiconductor materials; calibration of detectors; Bragg-Gray theory; measurement chain and uncertainties associated to measurements

  9. Scintillator plate calorimetry

    International Nuclear Information System (INIS)

    Price, L.E.

    1990-01-01

    Calorimetry using scintillator plates or tiles alternated with sheets of (usually heavy) passive absorber has been proven over multiple generations of collider detectors. Recent detectors including UA1, CDF, and ZEUS have shown good results from such calorimeters. The advantages offered by scintillator calorimetry for the SSC environment, in particular, are speed (<10 nsec), excellent energy resolution, low noise, and ease of achieving compensation and hence linearity. On the negative side of the ledger can be placed the historical sensitivity of plastic scintillators to radiation damage, the possibility of nonuniform response because of light attenuation, and the presence of cracks for light collection via wavelength shifting plastic (traditionally in sheet form). This approach to calorimetry is being investigated for SSC use by a collaboration of Ames Laboratory/Iowa State University, Argonne National Laboratory, Bicron Corporation, Florida State University, Louisiana State University, University of Mississippi, Oak Ridge National Laboratory, Virginia Polytechnic Institute and State University, Westinghouse Electric Corporation, and University of Wisconsin

  10. Scintillating plate calorimeter optical design

    International Nuclear Information System (INIS)

    McNeil, R.; Fazely, A.; Gunasingha, R.; Imlay, R.; Lim, J.

    1990-01-01

    A major technical challenge facing the builder of a general purpose detector for the SSC is to achieve an optimum design for the calorimeter. Because of its fast response and good energy resolution, scintillating plate sampling calorimeters should be considered as a possible technology option. The work of the Scintillating Plate Calorimeter Collaboration is focused on compensating plate calorimeters. Based on experimental and simulation studies, it is expected that a sampling calorimeter with alternating layers of high-Z absorber (Pb, W, DU, etc.) and plastic scintillator can be made compensating (e/h = 1.00) by suitable choice of the ratio of absorber/scintillator thickness. Two conceptual designs have been pursued by this subsystem collaboration. One is based on lead as the absorber, with read/out of the scintillator plates via wavelength shifter fibers. The other design is based on depleted uranium as the absorber with wavelength shifter (WLS) plate readout. Progress on designs for the optical readout of a compensating scintillator plate calorimeter are presented. These designs include readout of the scintillator plates via wavelength shifter plates or fiber readout. Results from radiation damage studies of the optical components are presented

  11. B-factory detectors

    International Nuclear Information System (INIS)

    Marlow, D.R.

    2002-01-01

    The designs of the recently commissioned BaBar and Belle B-Factory detectors are described. The discussion is organized around the methods and instruments used to detect the so-called gold-plated-mode B 0 →J/ΨK S decays and related modes

  12. Toward a noncytotoxic glioblastoma therapy: blocking MCP-1 with the MTZ Regimen

    Directory of Open Access Journals (Sweden)

    Salacz ME

    2016-04-01

    Full Text Available Michael E Salacz,1,2 Richard E Kast,3 Najmaldin Saki,4 Ansgar Brüning,5 Georg Karpel-Massler,6 Marc-Eric Halatsch6 1Department of Internal Medicine, 2Department of Neurosurgery, University of Kansas, Kansas City, KS, USA; 3IIAIGC Study Center, Burlington, VT, USA; 4Health Research Institute, Research Center of Thalassemia and Hemoglobinopathy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; 5Molecular Biology Laboratory, University Hospital Munich, Munich, Germany; 6Department of Neurosurgery, University of Ulm, Ulm, Germany Abstract: To improve the prognosis of glioblastoma, we developed an adjuvant treatment directed to a neglected aspect of glioblastoma growth, the contribution of nonmalignant monocyte lineage cells (MLCs (monocyte, macrophage, microglia, dendritic cells that infiltrated a main tumor mass. These nonmalignant cells contribute to glioblastoma growth and tumor homeostasis. MLCs comprise of approximately 10%–30% of glioblastoma by volume. After integration into the tumor mass, these become polarized toward an M2 immunosuppressive, pro-angiogenic phenotype that promotes continued tumor growth. Glioblastoma cells initiate and promote this process by synthesizing 13 kDa MCP-1 that attracts circulating monocytes to the tumor. Infiltrating monocytes, after polarizing toward an M2 phenotype, synthesize more MCP-1, forming an amplification loop. Three noncytotoxic drugs, an antibiotic – minocycline, an antihypertensive drug – telmisartan, and a bisphosphonate – zoledronic acid, have ancillary attributes of MCP-1 synthesis inhibition and could be re-purposed, singly or in combination, to inhibit or reverse MLC-mediated immunosuppression, angiogenesis, and other growth-enhancing aspects. Minocycline, telmisartan, and zoledronic acid – the MTZ Regimen – have low-toxicity profiles and could be added to standard radiotherapy and temozolomide. Re-purposing older drugs has advantages of established safety and low

  13. Influência do 1-MCP na conservação pós-colheita de rosas cv. Vega Influence of 1-MCP on postharvest conservation of roses cv. Vega

    Directory of Open Access Journals (Sweden)

    Júlia De Pietro

    2010-10-01

    Full Text Available Objetivou-se, neste trabalho, estudar aspectos da fisiologia pós-colheita de rosas cortadas cv. Vega, tratadas com diferentes concentrações de 1-metilcicloropropeno (1-MCP. O experimento foi conduzido em delineamento inteiramente casualizado, em esquema fatorial composto por dois fatores: quatro tratamentos pós-colheita e quatro datas de avaliação (0; 4; 8; 12 dias. As flores foram submetidas aos seguintes tratamentos: 1 Água destilada (controle; 2 1-MCP (100 ppb; 3 1-MCP (250 ppb; 4 1-MCP (500 ppb. Foram realizadas as seguintes avaliações: massa fresca, cor, turgescência, curvatura, taxa respiratória, conteúdo relativo de água, conteúdo de carboidratos solúveis, de redutores e de antocianina. Ao contrário do tratamento controle, todas as concentrações de 1-MCP foram eficientes para retardar a senescência das flores, porém, a concentração de 1-MCP a 500 ppb destacou-se pela melhor manutenção da qualidade, além de prolongar a vida decorativa das hastes até 19 dias.The objective of this work was to study aspects of postharvest physiology of cut roses cv. Vega, treated with different concentrations of 1-metilcloropropene (1-MCP. The experiment was conducted in a complete randomized design composed of two factors: four postharvest treatments and four dates of evaluation (0; 4; 8; 12 days. The following treatments were used: 1 distilled water; 2 1-metilciclopropeno (1-MCP 100 ppb; 3 1-MCP 250 ppb; 4 1-MCP 500 ppb. The following evaluations were made: fresh weight, color, turgor, curvature, respiration rate, relative water content, content of soluble carbohydrates, reducing and anthocyanin. Unlike treatment with distilled water, all concentrations of 1-MCP were effective in delaying the senescence of flowers; however, the concentration of 1-MCP at 500 ppb was highlighted by better maintenance of quality and extended decorate life stem up to 19 days.

  14. The role of MCP-1-CCR2 ligand-receptor axis in chondrocyte degradation and disease progress in knee osteoarthritis

    Directory of Open Access Journals (Sweden)

    Yuan-kun Xu

    Full Text Available BACKGROUND: Osteoarthritis (OA is a common arthritic disease and multifactorial whole-joint disease. Interactions of chemokines and OA is inadequately documented RESULTS: In vivo and in vitro studies were conducted to investigate monocyte chemoattractant protein 1 (MCP-1 and receptor chemokine (C-C motif receptor 2 (CCR2 in chondrocyte degradation and cartilage degeneration. Chondrocytes from 16 OA patients and 6 normal controls were involved in this study. After stimulation of MCP-1, the expression of MCP-1 and CCR2 increased significantly (P < 0.001 and the expression of MMP-13 also increased (P < 0.05. MCP-1 stimulation also induced (or enhanced the apoptosis of OA chondrocytes (P < 0.05. Additionally, the degradation of cartilage matrix markers (metalloproteinase 3 and 13, MMP3 and MMP13 in the culture medium of normal chondrocytes was also assessed. Furthermore, intra-articular injection of MCP-1 in mouse knees induced cartilage degradation and the CCR2 antagonist did not impede cartilage destroy in rats knees of monosodium iodoacetate (MIA model CONCLUSIONS: The results of this study demonstrate that the MCP-1-CCR2 ligand-receptor axis plays a special role in the initiation and progression of OA pathology. Patients with ambiguous etiology can gain some insight from the MCP-1-CCR2 ligand-receptor axis

  15. Localization of monocyte chemotactic and activating factor (MCAF/MCP-1) in psoriasis

    DEFF Research Database (Denmark)

    Deleuran, M; Buhl, L; Ellingsen, T

    1996-01-01

    in the epidermal pustules in pustular psoriasis. In normals positive staining was observed in all the layers of the epidermis and in a few perivascular cells and blood vessels in the dermis. Where present in normal and diseased skin, eccrine ducts of sweat glands and sebaceous glands stained positive for MCAF......The monocyte chemotactic protein-1 (MCAF) also termed MCP-1, a strong chemotactic factor towards monocytes, is produced by several cell types present in the skin. The in situ presence of MCAF/MCP-1 protein in the skin has, however, not yet been established. Using immunohistochemical techniques we...... have investigated the distribution of MCAF in skin from patients with different types of psoriasis and normal healthy volunteers. We report the novel finding that psoriasis has strong positive immunostaining for MCAF located to all the layers of the epidermis, except the stratum granulosum, in pustular...

  16. Conservação da qualidade de caqui 'Fuyu' em ambiente refrigerado pela combinação de 1-MCP e atmosfera modificada Quality maintenance of 'Fuyu' persimmon in cold storage by combining 1-MCP and modified atmosphere

    Directory of Open Access Journals (Sweden)

    Luiz Carlos Argenta

    2009-06-01

    Full Text Available O presente estudo analisou os efeitos do inibidor da ação do etileno 1-MCP (1-metilciclopropeno, da AM (atmosfera modificada e do oxidante de etileno KMnO4 (permanganato de potássio sobre a qualidade de caqui 'Fuyu' após a armazenagem refrigerada. Os fatores 1-MCP, AM e KMnO4 foram combinados de quatro maneiras, correspondendo aos seguintes tratamentos: T1 Controle + AM + KMnO4;T2 1-MCP + AM + KMnO4; T3 1-MCP + AM, e T4 1-MCP + AA (AA=atmosfera do ar. Frutos maduro-firmes com coloração da casca predominantemente amarela foram colhidos em sete pomares comerciais no nordeste do Estado do Rio Grande do Sul. Parte dos frutos foi exposta a 0.3 µL L-1 de 1-MCP por 12 h em 24 h após a colheita. A seguir, os frutos foram armazenados sob AA ou sob AM induzida por bolsas de polietileno (0,04 mm de espessura, por 20; 40; 60 ou 80 dias a -0,1±0,8ºC. Dois sachês contendo 8,5 g de Alumina-KMnO4foram adicionados em cada uma das bolsas de polietileno dos tratamentos um e dois, antes de elas serem vedadas. Os frutos de cada período de armazenagem refrigerada foram analisados após 0; 3; 6 ou 9 dias de prateleira sob AA a 22±1ºC. O tratamento 1-MCP retardou o amolecimento da polpa, mas não afetou consistentemente o desenvolvimento de 'estrias' e manchas pretas na superfície dos frutos armazenados sob AM contendo KMnO4. A incidência de 'estrias' e manchas pretas em frutos tratados com 1-MCP e armazenados sob AM foi significativamente menor que a de frutos tratados com 1-MCP e armazenados sob AA. Houve efeitos aditivos do 1-MCP e AM na conservação da firmeza e na redução de danos por frio manifestados pela formação de textura gel-firme e manchas translúcidas na casca. O uso de KMnO4 não aumentou a conservação da qualidade dos frutos quando tratados com 1-MCP e armazenados sob AM. O desenvolvimento dos distúrbios da epiderme dependeu do pomar e de períodos de armazenagem e prateleira. No entanto, os benefícios da combinação de 1-MCP e

  17. Role of human pulmonary fibroblast-derived MCP-1 in cell activation and migration in experimental silicosis

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Xueting [Department of Physiology, Medical School of Southeast University, Nanjing, Jiangsu 210009 (China); Fang, Shencun [Nine Department of Respiratory Medicine, Nanjing Chest Hospital, Nanjing, Jiangsu 210029 (China); Liu, Haijun [Neurobiology Laboratory, New Drug Screening Centre, China Pharmaceutical University, Nanjing, Jiangsu 210009 (China); Wang, Xingang; Dai, Xiaoniu; Yin, Qing; Yun, Tianwei [Department of Physiology, Medical School of Southeast University, Nanjing, Jiangsu 210009 (China); Wang, Wei; Zhang, Yingming [Nine Department of Respiratory Medicine, Nanjing Chest Hospital, Nanjing, Jiangsu 210029 (China); Liao, Hong [Neurobiology Laboratory, New Drug Screening Centre, China Pharmaceutical University, Nanjing, Jiangsu 210009 (China); Zhang, Wei [Department of Physiology, Medical School of Southeast University, Nanjing, Jiangsu 210009 (China); Yao, Honghong [Department of Pharmacology, Medical School of Southeast University, Nanjing, Jiangsu 210009 (China); Chao, Jie, E-mail: chaojie@seu.edu.cn [Department of Physiology, Medical School of Southeast University, Nanjing, Jiangsu 210009 (China)

    2015-10-15

    Background: Silicosis is a systemic disease caused by inhaling silicon dioxide (SiO{sub 2}). Phagocytosis of SiO{sub 2} in the lung initiates an inflammatory cascade that results in fibroblast proliferation and migration and subsequent fibrosis. Clinical evidence indicates that the activation of alveolar macrophages by SiO{sub 2} produces rapid and sustained inflammation that is characterized by the generation of monocyte chemotactic protein 1 (MCP-1), which induces fibrosis. Pulmonary fibroblast-derived MCP-1 may play a critical role in fibroblast proliferation and migration. Methods and results: Experiments using primary cultured adult human pulmonary fibroblasts (HPF-a) demonstrated the following results: 1) SiO{sub 2} treatment resulted in the rapid and sustained induction of MCP-1 as well as the elevation of the CC chemokine receptor type 2 (CCR2) protein levels; 2) pretreatment of HPF-a with RS-102895, a specific CCR2 inhibitor, abolished the SiO{sub 2}-induced increase in cell activation and migration in both 2D and 3D culture systems; and 3) RNA interference targeting CCR2 prevented the SiO{sub 2}-induced increase in cell migration. Conclusion: These data demonstrated that the up-regulation of pulmonary fibroblast-derived MCP-1 is involved in pulmonary fibroblast migration induced by SiO{sub 2}. CCR2 was also up-regulated in response to SiO{sub 2}, and this up-regulation facilitated the effect of MCP-1 on fibroblasts. Our study deciphered the link between fibroblast-derived MCP-1 and SiO{sub 2}-induced cell migration. This finding provides novel insight into the potential of MCP-1 in the development of novel therapeutic strategies for silicosis. - Highlights: • Role of pulmonary fibroblast-derived MCP-1 in experimental silicosis was studied. • SiO{sub 2} induced MCP-1 release from cultured human pulmonary fibroblast (HPF-a). • SiO{sub 2} directly activated HPF-a via the MCP-1/CCR2 pathway. • SiO{sub 2} increased HPF-a migration in both 2D and 3D

  18. Role of human pulmonary fibroblast-derived MCP-1 in cell activation and migration in experimental silicosis

    International Nuclear Information System (INIS)

    Liu, Xueting; Fang, Shencun; Liu, Haijun; Wang, Xingang; Dai, Xiaoniu; Yin, Qing; Yun, Tianwei; Wang, Wei; Zhang, Yingming; Liao, Hong; Zhang, Wei; Yao, Honghong; Chao, Jie

    2015-01-01

    Background: Silicosis is a systemic disease caused by inhaling silicon dioxide (SiO 2 ). Phagocytosis of SiO 2 in the lung initiates an inflammatory cascade that results in fibroblast proliferation and migration and subsequent fibrosis. Clinical evidence indicates that the activation of alveolar macrophages by SiO 2 produces rapid and sustained inflammation that is characterized by the generation of monocyte chemotactic protein 1 (MCP-1), which induces fibrosis. Pulmonary fibroblast-derived MCP-1 may play a critical role in fibroblast proliferation and migration. Methods and results: Experiments using primary cultured adult human pulmonary fibroblasts (HPF-a) demonstrated the following results: 1) SiO 2 treatment resulted in the rapid and sustained induction of MCP-1 as well as the elevation of the CC chemokine receptor type 2 (CCR2) protein levels; 2) pretreatment of HPF-a with RS-102895, a specific CCR2 inhibitor, abolished the SiO 2 -induced increase in cell activation and migration in both 2D and 3D culture systems; and 3) RNA interference targeting CCR2 prevented the SiO 2 -induced increase in cell migration. Conclusion: These data demonstrated that the up-regulation of pulmonary fibroblast-derived MCP-1 is involved in pulmonary fibroblast migration induced by SiO 2 . CCR2 was also up-regulated in response to SiO 2 , and this up-regulation facilitated the effect of MCP-1 on fibroblasts. Our study deciphered the link between fibroblast-derived MCP-1 and SiO 2 -induced cell migration. This finding provides novel insight into the potential of MCP-1 in the development of novel therapeutic strategies for silicosis. - Highlights: • Role of pulmonary fibroblast-derived MCP-1 in experimental silicosis was studied. • SiO 2 induced MCP-1 release from cultured human pulmonary fibroblast (HPF-a). • SiO 2 directly activated HPF-a via the MCP-1/CCR2 pathway. • SiO 2 increased HPF-a migration in both 2D and 3D model via the MCP-1/CCR2 pathway. • RNA-i of MCP-1/CCR2

  19. Role of MCP-1 in pleural effusion development in a carrageenan-induced murine model of pleurisy.

    Science.gov (United States)

    Lansley, Sally M; Cheah, Hui Min; Lee, Y C Gary

    2017-05-01

    Exudative pleural effusions affect over 1500 patients per million population each year. The pathobiology of pleural exudate formation remains unclear. Our recent study revealed monocyte chemotactic protein-1 (MCP-1) as a key driver of fibrinolytic-induced exudate effusion while another study found a role for MCP-1 in malignant effusion formation. In the present study, we further evaluated the role of MCP-1 in the development of pleural effusion in a mouse model of acute pleural inflammation. λ-Carrageenan (CAR) was injected into the pleural cavity of CD1 mice and pleural effusion volume measured up to 16 h post-injection. Pleural effusion and serum protein and MCP-1 concentrations were measured and differential cell counts performed in fluids. Mice were also treated with either intraperitoneal (i) anti-MCP-1 antibody or isotype control or (ii) an MCP-1 receptor (CCR2) antagonist or vehicle control 12 h prior to and at the time of CAR injection. Intrapleural CAR induced significant pleural fluid accumulation (300.0 ± 49.9 μL) in mice after 4 h. Pleural fluid MCP-1 concentrations were significantly higher than corresponding serum MCP-1 (144 603 ± 23 204 pg/mL vs 3703 ± 801 pg/mL, P pleural fluid formation was seen both with anti-MCP-1 antibody (median (interquartile range, IQR): 36 (0-168) μL vs controls 290 (70-436) μL; P = 0.02) or CCR2 antagonist (153 (30-222) μL vs controls 240 (151-331) μL, P = 0.0049). Blockade of MCP-1 activity significantly reduced inflammatory pleural effusion formation in a CAR model. Together with recent successes in MCP-1 blockade in other effusion formation models, our data strongly support clinical evaluation of MCP-1 antagonists as a novel approach to pleural fluid management. © 2016 Asian Pacific Society of Respirology.

  20. EFECTO DEL 1-METIL-CICLOPROPENO (1-MCP EN LA MADURACIÓN DE BANANO

    Directory of Open Access Journals (Sweden)

    Kattia Chang-Yuen

    2005-01-01

    Full Text Available Se evaluó la eficacia del 1-metil-ciclopropeno (1-MCP en la maduración del banano (Musa sp Cavendish, aplicado después del empaque en fruta para el mercado de EE.UU. y Europa. Se utilizó fruta de 3 diferentes compañías bananeras; la fruta fue expuesta a 0, 20 y 30 nl l-1 de 1-MCP, por 24 h. Posteriormente, fue sometida a simulación de transporte, según el mercado de destino (7 días EE.UU. y 15 días Europa. Finalizada la simulación se indujo el proceso de maduración con etileno. Las evaluaciones se realizaron cada 2 días, e incluyeron análisis de calidad externa (enfermedades poscosecha y desarrollo de color externo de la cáscara y de calidad interna (oBrix, firmeza, porcentaje de acidez titulable y tasa de produc ción de CO2. Una aplicación de 30 nl l-1 de 1-MCP, generó una ganancia de más de 4 días de vida de anaquel por encima de la fruta control.La apariencia externa y la calidad interna de la fruta no se vio afectada de forma negativa por la exposición al 1-MCP, aunque se recomienda realizar pruebas sensoriales con consumidores en los mercados de destino.

  1. State of art report for high temperature wear test of SMART MCP and CEDM bearing material

    International Nuclear Information System (INIS)

    Cho, Yong Hu; Lee, Jae Seon; Park, Jin Seok; Kim, Ji Ho; Kim, Jong In

    2000-03-01

    Wear resistance properties of machine elements has been more critical in view of its significant effect on life extension, economics and material saving because it has been recognized that nearly 80 percent of damages of mechanical elements in the friction pairs are due to the material loss by wear. And wear properties have direct influence on the life of a machine in a great extend under extremely severe operating condition. Therefore highly improved wear properties of machine elements operating in such circumstances is heavily required. The purpose of this report is to survey current technology for high temperature wear test in order to establish the test plan for the life evaluation of SMART MCP and CEDM bearing materials. Friction and wear test will be done under high pressure (170 MPa) and high temperature (350 degree C) with water as lubricant to simulate the operating condition of the nuclear power reactor. Because pump type for MCP is selected as the caned motor pump which needs no mechanical sealing, the rotating shaft on which bearing is fully submerged by main coolant with high temperature. So MCP bearing operates without additional lubricant. CEDM is adopted as the ball-screw type with fine controllability. So the driving part is designed as the immersed-in type by main coolant. Therefore the anti-wear and reliability of driving parts are much consequent to guarantee the lifetime and the safety of the whole system. Tribometer adapted to high temperature and pressure circumstance is needed to execute bearing material testing. Test parameters are material, sliding speed, sliding distance and applied load. In order to identify the wear mechanism, optical microscope and surface roughness testers are required. The result of this report will provide an elementary data to develop bearing materials and to estimate bearing lifetime for the bearings of MCP and CEDM in SMART. (author)

  2. Ethylene and 1-MCP regulate major volatile biosynthetic pathways in apple fruit.

    Science.gov (United States)

    Yang, Xiaotang; Song, Jun; Du, Lina; Forney, Charles; Campbell-Palmer, Leslie; Fillmore, Sherry; Wismer, Paul; Zhang, Zhaoqi

    2016-03-01

    The effects of ethylene and 1-methylcyclopropene (1-MCP) on apple fruit volatile biosynthesis and gene expression were investigated. Statistical analysis identified 17 genes that changed significantly in response to ethylene and 1-MCP treatments. Genes encoding branched-chain amino acid aminotransferase (BCAT), aromatic amino acid aminotransferase (ArAT) and amino acid decarboxylases (AADC) were up-regulated during ripening and further enhanced by ethylene treatment. Genes related to fatty acid synthesis and metabolism, including acyl-carrier-proteins (ACPs), malonyl-CoA:ACP transacylase (MCAT), acyl-ACP-desaturase (ACPD), lipoxygenase (LOX), hydroperoxide lyase (HPL), alcohol dehydrogenase (ADH), pyruvate decarboxylase (PDC2), β-oxidation, acyl-CoA synthetase (ACS), enoyl-CoA hydratase (ECHD), acyl-CoA dehydrogenase (ACAD), and alcohol acyltransferases (AATs) also increased during ripening and in response to ethylene treatment. Allene oxide synthase (AOS), alcohol dehydrogenase 1 (ADH1), 3-ketoacyl-CoA thiolase and branched-chain amino acid aminotransferase 2 (BCAT2) decreased in ethylene-treated fruit. Treatment with 1-MCP and ethylene generally produced opposite effects on related genes, which provides evidence that regulation of these genes is ethylene dependent. Crown Copyright © 2015. Published by Elsevier Ltd. All rights reserved.

  3. The cross-validated AUC for MCP-logistic regression with high-dimensional data.

    Science.gov (United States)

    Jiang, Dingfeng; Huang, Jian; Zhang, Ying

    2013-10-01

    We propose a cross-validated area under the receiving operator characteristic (ROC) curve (CV-AUC) criterion for tuning parameter selection for penalized methods in sparse, high-dimensional logistic regression models. We use this criterion in combination with the minimax concave penalty (MCP) method for variable selection. The CV-AUC criterion is specifically designed for optimizing the classification performance for binary outcome data. To implement the proposed approach, we derive an efficient coordinate descent algorithm to compute the MCP-logistic regression solution surface. Simulation studies are conducted to evaluate the finite sample performance of the proposed method and its comparison with the existing methods including the Akaike information criterion (AIC), Bayesian information criterion (BIC) or Extended BIC (EBIC). The model selected based on the CV-AUC criterion tends to have a larger predictive AUC and smaller classification error than those with tuning parameters selected using the AIC, BIC or EBIC. We illustrate the application of the MCP-logistic regression with the CV-AUC criterion on three microarray datasets from the studies that attempt to identify genes related to cancers. Our simulation studies and data examples demonstrate that the CV-AUC is an attractive method for tuning parameter selection for penalized methods in high-dimensional logistic regression models.

  4. Ethylene and 1-MCP affect the postharvest behavior of yellow pitahaya fruits (Selenicereus megalanthus Haw.

    Directory of Open Access Journals (Sweden)

    Yuli Alexandra Deaquiz

    2014-04-01

    Full Text Available The pitahaya or dragon fruit is one of the most representative exotic fruits that Colombia has, with an important, growing international market, but the cultivation and postharvest of this fruit lack sufficient technological support to be more competitive. Therefore, alternatives that provide good-quality products that meet market requirements are very important. Therefore, the objective of this research was to determine the effect of a ripening retardant and ethylene application on the conservation and quality of pitahaya fruits and the possible changes during ripening associated with ethylene, for which a completely randomized design with three treatments was used, corresponding to the application of ethylene (ethephon, 3 mL L-1, 1-methylcyclopropene (1-MCP, 600 mg L-1 and a control, with four replications, for a total of 12 experimental units. The fruits were stored at 18°C with 75% relative humidity. The 1-MCP application significantly decreased the loss of firmness, total soluble solids, loss of fresh mass and respiratory rate. Fruits from the control and ethylene treatment tended toward a climateric respiratory behavior. The total carotenoid content of the fruits was significantly higher in the ethylene application and the control treatment, which was consistent with the color change of the fruits. It can be concluded that the 1-MCP application reduced the ethylene action, slowing the ripening of the dragon fruits.

  5. The size and spatial distribution of microchannel plate output electron clouds

    International Nuclear Information System (INIS)

    Lapington, J.S.; Edgar, M.L.

    1989-01-01

    An experimental technique for measuring the spatial distribution of the output charge cloud from a microchannel plate (MCP), using a planar, charge-division-type anode is discussed. The anode simultaneously measures, for each charge cloud, both the position of the charge centroid and the fractional charge falling to one side of the split in the pattern. The measurements from several thousand events have been combined to calculate the average spatial distribution of the electron cloud and the dominant factors influencing the charge cloud distribution have been found to be the MCP gain and the MCP-anode accelerating field and geometry. Experimental research on the two dominant factors with respect to ranges of distribution is presented. 10 refs

  6. New approaches for a time- and position-resolved detector for positron annihilation spectroscopy at PLEPS

    Energy Technology Data Exchange (ETDEWEB)

    Ackermann, Ulrich; Egger, Werner; Sperr, Peter; Loewe, Benjamin; Ravelli, Luca; Koegel, Gottfried; Dollinger, Guenther [Universitaet der Bundeswehr Muenchen, LRT2 (Germany); Jagutzki, Ottmar [Universitaet Frankfurt, RoentDek GmbH (Germany)

    2013-07-01

    The pulsed low energy positron system PLEPS at NEPOMUC at the FRM II is a tool for depth resolved positron lifetime measurements. Besides positron lifetime measurements 2D-AMOC (two dimensional age momentum correlation) experiments are also possible. 2D-AMOC provides in coincidence the lifetime of the positron and the longitudinal momentum distribution of the annihilating electron. It would be of great scientific concern to measure simultaneously the entire 3D-momentum distribution of the annihilating electron and the corresponding lifetime of the positron (4D-AMOC). To perform 4D-AMOC measurements, a time and spatially resolving detector with a time resolution of about 100 ps (FWHM) and a spatial resolution of circa 2 mm over an area of about 12 cm{sup 2} is required in coincidence with a pixelated Ge-detector and currently under development at our institute. It is intended to use a MCP-based UV-light detector with two MCP-stages coupled to a BaF{sub 2} scintillator. To achieve the spatial resolution the centroid information of the photoelectron-cloud is detected with a position sensitive anode installed outside the housing of the MCP detector. As an alternative to a MCP-based detector, silicon photomultipliers are also envisaged.

  7. X-ray focusing with Wolter microchannel plate optics

    CERN Document Server

    Price, G J; Beijersbergen, M W; Fraser, G W; Bavdaz, M; Boutot, J P; Fairbend, R; Flyckt, S O; Peacock, A; Tomaselli, E

    2002-01-01

    Square-pore microchannel plate (MCP) X-ray optics of the 'lobster-eye' geometry have frequently been described in the literature. We have now investigated the use of a radial channel packing geometry which, in the context of an MCP pair slumped to the correct radii of curvature, can form a conic approximation to the Wolter Type I grazing incidence X-ray optic. Such an optic can provide a large effective area with very low mass and may be ideally suited for use in applications such as planetary imaging X-ray fluorescence. We present here the results of X-ray illumination of the first such optic, fabricated by Photonis SAS, France.

  8. Ionization detector

    International Nuclear Information System (INIS)

    Steele, D.S.

    1987-01-01

    An ionization detector having an array of detectors has, for example, grounding pads positioned in the spaces between some detectors (data detectors) and other detectors (reference detectors). The grounding pads are kept at zero electric potential, i.e. grounded. The grounding serves to drain away electrons and thereby prevent an unwanted accumulation of charge in the spaces, and cause the electric field lines to be more perpendicular to the detectors in regions near the grounding pads. Alternatively, no empty space is provided there being additional, grounded, detectors provided between the data and reference detectors. (author)

  9. Position-sensitive X-ray detectors

    International Nuclear Information System (INIS)

    Hendrix, J.

    1982-01-01

    In this review of the application of different types of position sensitive detectors to synchrotron radiation, discussion of the proportional counters based on the gas amplification principle forms a major part. Other topics reviewed are detector requirements, multiwire proportional chamber system, drift chamber type detectors, TV detectors, and recent developments, such as that based on a micro-channel plate as the amplifying element, and charge-coupled devices. (U.K.)

  10. Advanced Photon Counting Imaging Detectors with 100ps Timing for Astronomical and Space Sensing Applications

    Science.gov (United States)

    Siegmund, O.; Vallerga, J.; Welsh, B.; Rabin, M.; Bloch, J.

    In recent years EAG has implemented a variety of high-resolution, large format, photon-counting MCP detectors in space instrumentation for satellite FUSE, GALEX, IMAGE, SOHO, HST-COS, rocket, and shuttle payloads. Our scheme of choice has been delay line readouts encoding photon event position centroids, by determination of the difference in arrival time of the event charge at the two ends of a distributed resistive-capacitive (RC) delay line. Our most commonly used delay line configuration is the cross delay line (XDL). In its simplest form the delay-line encoding electronics consists of a fast amplifier for each end of the delay line, followed by time-to-digital converters (TDC's). We have achieved resolutions of Pulsar with a telescope as small as 1m. Although microchannel plate delay line detectors meet many of the imaging and timing demands of various applications, they have limitations. The relatively high gain (107) reduces lifetime and local counting rate, and the fixed delay (10's of ns) makes multiple simultaneous event recording problematic. To overcome these limitations we have begun development of cross strip readout anodes for microchannel plate detectors. The cross strip (XS) anode is a coarse (~0.5 mm) multi-layer metal and ceramic pattern of crossed fingers on an alumina substrate. The charge cloud is matched to the anode period so that it is collected on several neighboring fingers to ensure an accurate event charge centroid can be determined. Each finger of the anode is connected to a low noise charge sensitive amplifier and followed by subsequent A/D conversion of individual strip charge values and a hardware centroid determination of better than 1/100 of a strip are possible. Recently we have commissioned a full 32 x 32 mm XS open face laboratory detector and demonstrated excellent resolution (Los Alamos National Laboratory, NASA and NSF we are developing high rate (>107 Hz) XS encoding electronics that will encode temporally simultaneous

  11. Silicon detectors

    International Nuclear Information System (INIS)

    Klanner, R.

    1984-08-01

    The status and recent progress of silicon detectors for high energy physics is reviewed. Emphasis is put on detectors with high spatial resolution and the use of silicon detectors in calorimeters. (orig.)

  12. Plate tectonics

    Digital Repository Service at National Institute of Oceanography (India)

    Chaubey, A.K.

    's continental drift theory was later disproved, it was one of the first times that the idea of crustal movement had been introduced to the scientific community; and it has laid the groundwork for the development of modern plate tectonics. In the early... of the structure of the atom was to physical sciences and the theory of evolution was to the life sciences. Tectonics is the study of the forces within the Earth that give rise to continents, ocean basins, mountain ranges, earthquake belts and other large-scale...

  13. Create Your Plate

    Medline Plus

    Full Text Available ... Plate Share Create Your Plate ! Share: Seven Simple Steps to Create Your Plate It's simple and effective ... foods within each food category. Try these seven steps to get started: Using your dinner plate, put ...

  14. Phenolic excipients of insulin formulations induce cell death, pro-inflammatory signaling and MCP-1 release

    Directory of Open Access Journals (Sweden)

    Claudia Weber

    2015-01-01

    Insulin solutions displayed cytotoxic and pro-inflammatory potential caused by phenol or m-cresol. We speculate that during insulin pump therapy phenol and m-cresol might induce cell death and inflammatory reactions at the infusion site in vivo. Inflammation is perpetuated by release of MCP-1 by activated monocytic cells leading to enhanced recruitment of inflammatory cells. To minimize acute skin complications caused by phenol/m-cresol accumulation, a frequent change of infusion sets and rotation of the infusion site is recommended.

  15. Physical, chemical and sensory changes of refrigerated yellow pitahaya treated preharvest with 1-MCP

    OpenAIRE

    Liliana Serna Cock; Laura Sofía Torres Valenzuela; Alfredo Ayala Aponte

    2013-01-01

    El efecto de la aplicación de soluciones acuosas de 0, 200 y 400 mg L de 1-metilciclopropeno (1-MCP) en pitahaya amarilla en precosecha (Selenicereus megalanthus Haw) fue evaluado. Se midieron los cambios en pérdida de peso, cambio total de la coloración, azucares totales, acidez titulable, ácido ascórbico y análisis sensorial. La pitahaya fue almacenada bajo refrigeración (10°C y 85% de humedad relativa por 29 días). Dos tipos de empaque (Cajas para exportación y canastillas plá...

  16. Temporal cascade of inflammatory cytokines and cell-type populations in monocyte chemotactic protein-1 (MCP-1)-mediated aneurysm healing.

    Science.gov (United States)

    Hoh, Brian L; Fazal, Hanain Z; Hourani, Siham; Li, Mengchen; Lin, Li; Hosaka, Koji

    2018-03-01

    We have previously shown that monocyte chemotactic protein-1 (MCP-1) promotes aneurysm healing. To determine the temporal cascade and durability of aneurysm healing. Murine carotid aneurysms were treated with MCP-1-releasing or poly(lactic-co-glycolic) acid (PLGA)-only coils. Aneurysm healing was assessed by quantitative measurements of intraluminal tissue ingrowth on 5 μm sections by blinded observers. Aneurysm healing occurred in stages characteristic of normal wound healing. The 1st stage (day 3) was characterized by a spike in neutrophils and T cells. The 2nd stage (week 1) was characterized by an influx of macrophages and CD45+ cells significantly greater with MCP-1 than with PLGA (p<0.05). The third stage (week 2-3) was characterized by proliferation of smooth muscle cells and fibroblasts (greater with MCP-1 than with PLGA, p<0.05). The fourth stage (3-6 months) was characterized by leveling off of smooth muscle cells and fibroblasts. M1 macrophages were greater at week 1, whereas M2 macrophages were greater at weeks 2 and 3 with MCP-1 than with PLGA. Interleukin 6 was present early and increased through week 2 (p<0.05 compared with PLGA) then decreased and leveled off through 6 months. Tumour necrosis factor α was present early and remained constant through 6 months. MCP-1 and PLGA treatment had similar rates of tissue ingrowth at early time points, but MCP-1 had a significantly greater tissue ingrowth at week 3 (p<0.05), which persisted for 6 months. The sequential cascade is consistent with an inflammatory model of injury, repair, and remodeling. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  17. The roles of MCP-1 and protein kinase C delta activation in human eosinophilic leukemia EoL-1 cells.

    Science.gov (United States)

    Lee, Ji-Sook; Yang, Eun Ju; Kim, In Sik

    2009-12-01

    Idiopathic hypereosinophilc syndrome is a disorder associated with clonally eosinophilic proliferation. The importance of FIP1-like-1-platelet-derived growth factor receptor-alpha (FIP1L1-PDGFRA) in the pathogenesis and classification of HES has been recently reported. In this study, we investigated the contribution of monocyte chemoattractant protein-1 (MCP-1)/CCL2 to chemotactic activity and protein kinase C delta (PKC delta in the human eosinophilic leukemia cell line EoL-1. These cells express CCR2 protein among the CC chemokine receptors (CCR1-5). MCP-1 induces strong migration of EoL-1 cells and the chemotaxis signal in response to MCP-1 involves a G(i)/G(o) protein, phospholipase C (PLC), PKC delta, p38 MAPK and NF-kappaB. MCP-1 activates p38 MAPK via G(i)/G(o) protein, PLC and PKC delta cascade. MCP-1 also induces NF-kappaB translocation and the activation is inhibited by PKC delta activation. The increase in the basal expression and activity of PKC delta in EoL-1 cells, compared to normal eosinophils, inhibits apoptosis in EoL-1 cells. Anti-apoptotic mechanism of PKC delta is related to inhibition of caspase 3 and caspase 9, but not to FIP1L1-PDGFRA. PKC delta functions as an anti-apoptotic molecule, and is involved in EoL-1 cell movement stimulated by MCP-1. This study contributes to an understanding of MCP-1 in eosinophil biology and pathogenic mechanism of eosinophilic disorders.

  18. Myocardial production and release of MCP-1 and SDF-1 following myocardial infarction: differences between mice and man

    Directory of Open Access Journals (Sweden)

    Palasubramaniam Dharshan

    2011-09-01

    Full Text Available Abstract Background Stem cell homing to the heart is mediated by the release of chemo-attractant cytokines. Stromal derived factor -1 alpha (SDF-1a and monocyte chemotactic factor 1(MCP-1 are detectable in peripheral blood after myocardial infarction (MI. It remains unknown if they are produced by, and released from, the heart in order to attract stem cells to repair the damaged myocardium. Methods Murine hearts were studied for expression of MCP-1 and SDF-1a at day 3 and day 28 following myocardial infarction to determine whether production is increased following MI. In addition, we studied the coronary artery and coronary sinus (venous blood from patients with normal coronary arteries, stable coronary artery disease (CAD, unstable angina and MI to determine whether these cytokines are released from the heart into the systemic circulation following MI. Results Both MCP-1 and SDF-1a are constitutively produced and released by the heart. MCP-1 mRNA is upregulated following murine experimental MI, but SDF-1a is suppressed. There is less release of SDF-1a into the systemic circulation in patients with all stages of CAD including MI, mimicking the animal model. However MCP-1 release from the human heart following MI is also suppressed, which is the exact opposite of the animal model. Conclusions SDF-1a and MCP-1 release from the human heart are suppressed following MI. In the case of SDF-1a, the animal model appropriately reflects the human situation. However, for MCP-1 the animal model is the exact opposite of the human condition. Human observational studies like this one are paramount in guiding translation from experimental studies to clinical trials.

  19. Atraso do amadurecimento de banana 'Maçã' pelo 1-MCP, aplicado previamente à refrigeração Ripening delay of 'Apple' banana submitted to 1-MCP, prevoiously applied to refrigeration

    Directory of Open Access Journals (Sweden)

    Gustavo Costa Almeida

    2006-08-01

    Full Text Available O objetivo deste trabalho foi avaliar o efeito de diferentes períodos de exposição da banana 'Maçã' a 50 ppb de 1-MCP (0; 3; 6; 9; 12 e 24 horas sobre sua vida pós-colheita e qualidade. Após exposição ao 1-MCP, os frutos verde-maturos foram armazenados por 30 dias em câmaras com temperatura de 13ºC ± 0,5 e umidade relativa de 95%. Em seguida, as bananas foram armazenadas à temperatura de 20ºC ± 1, até amarelecimento completo da casca. A exposição de banana 'Maçã' a 50 ppb de 1-MCP, por 9 horas, retardou em 7 dias o seu amadurecimento, em comparação a frutos não expostos ao 1-MCP, após 30 dias de armazenamento refrigerado (13ºC, sem prejuízos à sua aparência e composição química. A exposição de banana 'Maçã' a 50 ppb de 1-MCP, por 3 e 6 horas, não estendeu sua vida pós-colheita, tampouco alterou sua composição química. Embora a exposição de banana 'Maçã' a 50 ppb de 1-MCP, por 12 e 24 horas, tenha retardado o seu amadurecimento, promoveu alterações indesejáveis na casca do fruto. Logo, a aplicação de 50 ppb de 1-MCP, por 9 horas, antes da refrigeração, constitui-se numa alternativa viável para prolongar o período de comercialização da banana.The aim of this work was to evaluate 'Apple' banana different periods exposure effect to 50 ppb of 1-MCP (0, 3, 6, 9 and 24 hours on its postharvest life and quality. Mature-green fruits were stored for 30 days in chambers at 13ºC + 0,5 and relative humidity 95%, after exposure to 1-MCP. Then, the bananas were stored at 20ºC + 1 until peel complete yellowing. 'Apple' banana to 50 ppb of 1-MCP exposure during 9 hours delayed in seven days the fruit ripening, comparing to fruit control, after 30 days of cool storage (13ºC, without changing its appearance and chemical composition. The exposure of 'Apple' banana to 50 ppb of 1-MCP for 3 and 6 hours did not extend its postharvest life; neither changed its chemical composition. Although the exposure of

  20. RETARDAMENTO DA MATURAÇÃO DE MAÇÃS 'FUJI' PELO TRATAMENTO COM 1-MCP E MANEJO DA TEMPERATURA DELAYING 'FUJI' APPLE RIPENING BY 1-MCP TREATMENT AND MANAGEMENT OF STORAGE TEMPERATURE

    Directory of Open Access Journals (Sweden)

    LUIZ CARLOS ARGENTA

    2001-08-01

    Full Text Available Maçãs cv. Fuji foram tratadas com 42 mimol·m-3 de 1-metilciclopropeno (1-MCP por 24 h a 20°C, um dia após a colheita, e então armazenadas a 0; 10 ou 20ºC por 70 dias. Tratamento com 1-MCP efetivamente retardou a maturação de maçãs 'Fuji'. 1-MCP reduziu a taxa respiratória dos frutos mantidos a 10 e 20ºC e inibiu a produção de etileno dos frutos mantidos nas três temperaturas de armazenagem. Frutos tratados com 1-MCP e armazenados a 20ºC exibiram taxas respiratórias similares ou inferiores àquelas de frutos-controle armazenados a 10ºC. Quando armazenados a 10 ou 20ºC, frutos tratados com 1-MCP preservaram mais a firmeza da polpa e a acidez titulável e exibiram menor amarelecimento da epiderme que frutos-controle. Entretanto, não houve benefícios significativos do tratamento 1-MCP sobre a conservação da qualidade dos frutos armazenados a 0ºC no período de 70 dias após a colheita. Os resultados indicam que o tratamento com 1-MCP pode ser uma estratégia para o aumento da conservação de maçãs cv. Fuji durante o transporte e a distribuição sob 10 ou 20ºC. O prolongamento da armazenagem a 20ºC por período superior a 40 dias pode ser limitado pelo murchamento dos frutos e desenvolvimento de podridões.'Fuji' apples were treated with 42 mumol·m-3 of 1-methylcyclopropene (1-MCP for 24 h at 20°C then stored at 0, 10 or 20 ºC for 70 days. MCP treatment reduced respiration on fruit held at 10 and 20 ºC and inhibited ethylene production regardless of storage temperature. Treated fruits held at 20ºC presented respiration rate similar to those of untreated fruits held at 10ºC. For fruit held at 10 or 20ºC, MCP treatment inhibited softening, loss of acidity and color changes on fruit surface. However, there was no considerable benefit of 1-MCP treatment on maintenance of fruit quality during short-term (70 days and storage at 0ºC. Results indicated that 1-MCP is an effective mean to delay ripening and to retain

  1. The human MCP-2 gene (SCYA8): Cloning, sequence analysis, tissue expression, and assignment to the CC chemokine gene contig on chromosome 17q11.2

    Energy Technology Data Exchange (ETDEWEB)

    Van Coillie, E.; Fiten, P.; Van Damme, J.; Opdenakker, G. [Univ. of Leuven (Belgium)] [and others

    1997-03-01

    Monocyte chemotactic proteins (MCPs) form a subfamily of chemokines that recruit leukocytes to sites of inflammation and that may contribute to tumor-associated leukocyte infiltration and to the antiviral state against HIV infection. With the use of degenerate primers that were based on CC chemokine consensus sequences, the known MIP-1{alpha}/LD78{alpha}, MCP-1, and MCP-3 genes and the previously unidentified eotaxin and MCP-2 genes were isolated from a YAC contig from human chromosome 17q11.2. The amplified genomic MCP-2 fragment was used to isolate an MCP-2 cosmid from which the gene sequence was determined. The MCP-2 gene shares with the MCP-1 and MCP-3 genes a conserved intron-exon structure and a coding nucleotide sequence homology of 77%. By Northern blot analysis the 1.0-kb MCP-2 mRNA was predominantly detectable in the small intestine, peripheral blood, heart, placenta, lung, skeletal muscle, ovary, colon, spinal cord, pancreas, and thymus. Transcripts of 1.5 and 2.4 kb were found in the testis, the small intestine, and the colon. The isolation of the MCP-2 gene from the chemokine contig localized it on YAC clones of chromosome 17q11.2, which also contain the eotaxin, MCP-1, MCP-3, and NCC-1/MCP-4 genes. The combination of using degenerate primer PCR and YACs illustrates that novel genes can efficiently be isolated from gene cluster contigs with less redundancy and effort than the isolation of novel ESTs. 42 refs., 5 figs., 2 tabs.

  2. 4th International Conference on New Photo-Detectors

    CERN Document Server

    2016-01-01

    The purpose of this Conference is to discuss new ideas and recent developments in photo-detectors and their applications in various fields: high energy physics, neutrino physics, particle and astroparticle physics, nuclear physics, nuclear medicine and industry. The main topics of the Conference relate to APD, SiPM, PMT, Hybrid PMT, MCP-PMT, and electronics: front-end and readout of large systems.

  3. MCP-1, ICAM-1 and VCAM-1 are present in early aneurysmal dilatation in experimental rats

    International Nuclear Information System (INIS)

    Jun Fan; Hao-Tong; Jing Di; Fang Liu; Hai-Hua Zhao; Shu-Ling Bai; Xiang Li; Linlin Zhong

    2010-01-01

    Recent studies have suggested that inflammation actively participates in ascending aortic aneurysm formation. The aim of the present study was to evaluate the expression changes of adhesion molecules and MMPs in an experimental model of ascending aortic aneurysm induced by ascending aorta banding in Wistar rats. Twelve rats developed aortic dilation after ascending aorta banding treatment, while nine normal animals underwent surgery without banding were used as controls. Light microscope and scanning electron microscope showed that the wall of the ascending aorta became disorganized as well as infiltration by inflammatory cells in aneurysmal rats. By using immunohistochemical techniques, a significant increase in the immunostaining of MCP-1 was observed in the aneurysmal wall as compared to the normal aortic wall. Under similar experimental conditions, we also found that the immunostaining of ICAM-1 and VCAM-1 was markedly increased in the aneurysmal wall. In addition, gelatin zymo graphic analysis showed that the expression and activities of MMP-2 and MMP-9 were remarkably enhanced in the ascending aorta of ascending aortic aneurysmal rats as compared to normal rats. These results demonstrate that MCP-1, ICAM-1 and VCAM-1 are involved in the pathogenesis of ascending aortic aneurysm and an increase in the immunostaining and activity of MMP-2 and MMP-9 may promote the progression of ascending aortic aneurysm. (authors)

  4. TRPV1 and the MCP-1/CCR2 Axis Modulate Post-UTI Chronic Pain.

    Science.gov (United States)

    Rosen, John M; Yaggie, Ryan E; Woida, Patrick J; Miller, Richard J; Schaeffer, Anthony J; Klumpp, David J

    2018-05-08

    The etiology of chronic pelvic pain syndromes remains unknown. In a murine urinary tract infection (UTI) model, lipopolysaccharide of uropathogenic E. coli and its receptor TLR4 are required for post-UTI chronic pain development. However, downstream mechanisms of post-UTI chronic pelvic pain remain unclear. Because the TRPV1 and MCP-1/CCR2 pathways are implicated in chronic neuropathic pain, we explored their role in post-UTI chronic pain. Mice were infected with the E. coli strain SΦ874, known to produce chronic allodynia, and treated with the TRPV1 antagonist capsazepine. Mice treated with capsazepine at the time of SΦ874 infection failed to develop chronic allodynia, whereas capsazepine treatment of mice at two weeks following SΦ874 infection did not reduce chronic allodynia. TRPV1-deficient mice did not develop chronic allodynia either. Similar results were found using novelty-suppressed feeding (NSF) to assess depressive behavior associated with neuropathic pain. Imaging of reporter mice also revealed induction of MCP-1 and CCR2 expression in sacral dorsal root ganglia following SΦ874 infection. Treatment with a CCR2 receptor antagonist at two weeks post-infection reduced chronic allodynia. Taken together, these results suggest that TRPV1 has a role in the establishment of post-UTI chronic pain, and CCR2 has a role in maintenance of post-UTI chronic pain.

  5. Combined use of serum MCP-1/IL-10 ratio and uterine artery Doppler index significantly improves the prediction of preeclampsia.

    Science.gov (United States)

    Cui, Shihong; Gao, Yanan; Zhang, Linlin; Wang, Yuan; Zhang, Lindong; Liu, Pingping; Liu, Ling; Chen, Juan

    2017-10-01

    Monocyte chemotactic protein-1 (MCP-1, or CCL2) is a member of the chemokine subfamily involved in recruitment of monocytes in inflammatory tissues. IL-10 is a key regulator for maintaining the balance of anti-inflammatory and pro-inflammatory milieu at the feto-maternal interface. Doppler examination has been routinely performed for the monitoring and management of preeclampsia patients. This study evaluates the efficiency of these factors alone, or in combination, for the predication of preeclampsia. The serum levels of MCP-1 and IL-10 in 78 preeclampsia patients and 143 age-matched normal controls were measured. The Doppler ultrasonography was performed and Artery Pulsatility Index (PI) and Resistance Index (RI) were calculated for the same subjects. It was found that while the second-trimester serum MCP-1, IL-10, MCP-1/IL-10 ratio, PI, and RI showed some power in predicting preeclampsia, the combination of MCP-1/IL-10 and PI and RI accomplishes the highest efficiency, achieving an AUC of 0.973 (95% CI, 0.000-1.000, Ppreeclampsia. Future studies using a larger sample can be conducted to construct an algorithm capable of quantitative assessment on the risk of preeclampsia. Copyright © 2016 Elsevier B.V. All rights reserved.

  6. Detectors - Electronics; Detecteurs - Electronique

    Energy Technology Data Exchange (ETDEWEB)

    Bregeault, J.; Gabriel, J.L.; Hierle, G.; Lebotlan, P.; Leconte, A.; Lelandais, J.; Mosrin, P.; Munsch, P.; Saur, H.; Tillier, J. [Lab. de Physique Corpusculaire, Caen Univ., 14 (France)

    1998-04-01

    The reports presents the main results obtained in the fields of radiation detectors and associated electronics. In the domain of X-ray gas detectors for the keV range efforts were undertaken to rise the detector efficiency. Multiple gap parallel plate chambers of different types as well as different types of X {yields} e{sup -} converters were tested to improve the efficiency (values of 2.4% at 60 KeV were reached). In the field of scintillators a study of new crystals has been carried out (among which Lutetium orthosilicate). CdTe diode strips for obtaining X-ray imaging were studied. The complete study of a linear array of 8 CdTe pixels has been performed and certified. The results are encouraging and point to this method as a satisfying solution. Also, a large dimension programmable chamber was used to study the influence of temperature on the inorganic scintillators in an interval from -40 deg. C to +150 deg. C. Temperature effects on other detectors and electronic circuits were also investigated. In the report mentioned is also the work carried out for the realization of the DEMON neutron multidetector. For neutron halo experiments different large area Si detectors associated with solid and gas position detectors were realized. In the frame of a contract with COGEMA a systematic study of Li doped glasses was undertaken aiming at replacing with a neutron probe the {sup 3}He counters presently utilized in pollution monitoring. An industrial prototype has been realised. Other studies were related to integrated analog chains, materials for Cherenkov detectors, scintillation probes for experiments on fundamental processes, gas position sensitive detectors, etc. In the field of associated electronics there are mentioned the works related to the multidetector INDRA, data acquisition, software gamma spectrometry, automatic gas pressure regulation in detectors, etc

  7. Aplicação de 1-MCP em caqui 'quioto' armazenado sob refrigeração e atmosfera controlada Effect of 1-MCP applied at different times during cold and Ca storage

    Directory of Open Access Journals (Sweden)

    Auri Brackmann

    2003-04-01

    Full Text Available O objetivo deste trabalho foi de avaliar o efeito do 1-MCP aplicado em diferentes épocas durante o armazenamento refrigerado (AR e em atmosfera controlada (AC sobre a qualidade do caqui cv. Quioto. O delineamento experimental utilizado foi o inteiramente casualizado, com quatro repetições de 30 frutos, e os tratamentos foram os seguintes: armazenamento refrigerado (AR; armazenamento refrigerado(AR + 1-MCP (1000ppb no início do armazenamento; armazenamento refrigerado(AR +1-MCP (1000ppb no final do armazenamento; armazenamento em atmosfera controlada (AC com 1kPa de O2 e AC 5kPa de CO2 e AC com 1kPa de O2 e 5kPa de CO2 + 1-MCP no fim do armazenamento, após 2 meses de armazenamento a -0,5ºC mais 5 dias de exposição dos frutos a 10ºC e 3 dias a 20ºC. No armazenamento refrigerado, o 1-MCP, aplicado tanto no início do armazenamento como no final, proporcionou maior firmeza de polpa. Para os parâmetros: sólidos solúveis totais, podridão e escurecimento da película, não houve diferença estatística entre os tratamentos. Conclui-se que a aplicação de 1-MCP, tanto no início como no final do armazenamento mantém elevada a firmeza de polpa.The objective of this work was to evaluate the effect of 1-MCP applied at different period during the cold storage (CS and in controlled atmosphere (CA on the quality of 'Quioto'. Persimmon. The experimental design was completely randomized with four replications of 30 fruits and the tested treatments were: cold storage (CS, cold storage + 1-MCP (1000ppb in the beginning of the storage, cold storage + 1-MCP (1000ppb in the end of the storage period; storage in controlled atmosphere (CA with 1kPa of O2 and 5kPa of CO2 and 1kPa of O2 and 5kPa of CO2 + 1-MCP in the end of the storage, after 2 months of storage at -0.5ºC, plus 5 days at 10ºC and 3 days at 20ºC. In the cooled storage, the 1-MCP, applied as in the beginning of the storage as in the end of the storage, provided greater pulp firmness

  8. Pós colheita de bananas-maçã submetidas ao 1-MCP e armazenadas á temperatura ambiente Postharvest of 'apple' banana submetted to 1-MCP and storage in room temperature

    Directory of Open Access Journals (Sweden)

    Ana Carla Marque Pinheiro

    2006-04-01

    Full Text Available Bananas da cultivar Maçã foram adquiridas no estádio dois de coloração da casca (verde maturos e submetidas à ação de 1-MCP. O 1-MCP foi aplicado por 12 horas nas seguintes concentrações: 0 (controle, 50, 100, 150, 200 hL.L-1. Após aplicação, os frutos foram armazenados à temperatura ambiente (temperatura média 20ºC ± 1 e umidade relativa 80% ± 5 e avaliados à medida que atingiam os graus 3, 5 e 7 de coloração da casca. O tratamento com 1-MCP atrasou o início do amadurecimento de bananas-maçã armazenadas sob temperatura ambiente, baseado nas primeiras mudanças de coloração da casca. A aplicação de 1-MCP em bananas-maçã, ditou maiores valores de perda de massa e relação polpa/casca (nos graus 5 e 7 de coloração da casca. O 1-MCP, nas doses 100, 150 e 200 hL.L-1 de 1-MCP promoveu desverdecimento desuniforme e tonalidade avermelhada na casca. O tratamento 50 hL.L-1 de 1-MCP é o mais adequado, por promover a extensão da vida pós-colheita de bananas-maçã da cultivar armazenadas sob temperatura ambiente sem afetar a coloração da casca dos frutos, apresentando qualidade, baseando-se na cor da casca, firmeza, acidez titulável, pH e sólidos solúveis, semelhante ao controle.Mature green 'Apple' bananas were submitted to five concentrations of 1-MCP (0, 50, 100, 150 and 200 hL.L-1 for 12 hours. After treatment, the fruits were stored at room temperature (20ºC ± 1 and 80% ± 5 RH and analyzed at 3,5 and 7 color degree of peel. The treatment with 1-MCP delayed the start of the ripening based in the first changes of peel color. The treatment of 'Apple' bananas with 1-MCP promoted higher values of mass loss and pulp/peel ratio (5 and 7 degrees of color peel. The fruits treated with 100, 150 and 200 nL.L-1 of 1-MCP showed heterogeneous degreening and development of red color on the peel. 1-MCP at 50 nL.L-1 was the most appropriated treatment for promoting the extension of postharvest life of 'Apple' bananas stored

  9. GANIL beam profile detectors

    International Nuclear Information System (INIS)

    Tribouillard, C.

    1997-01-01

    In the design phase of GANIL which started in 1977, one of the priorities of the project management was equipping the beamlines with a fast and efficient system for visualizing the beam position, thus making possible adjustment of the beam transport lines optics and facilitating beam control. The implantation of some thirty detectors was foreseen in the initial design. The assembly of installed detectors (around 190) proves the advantages of these detectors for displaying all the beams extracted from GANIL: transfer and transport lines, beam extracted from SISSI, very high intensity beam, secondary ion beams from the production target of the LISE and SPEG spectrometers, different SPIRAL project lines. All of these detectors are based on standard characteristics: - standard flange diameter (DN 160) with a standard booster for all the sensors; - identical analog electronics for all the detectors, with networking; - unique display system. The new micro-channel plate non-interceptive detectors (beam profile and ion packet lengths) make possible in-line control of the beam quality and accelerator stability. (author)

  10. Proceedings of the workshop on radiation detector and its application

    International Nuclear Information System (INIS)

    1996-01-01

    This workshop was held from January 23 to 25, 1996 at National Laboratory for High Energy Physics. At the workshop, lectures were given on the development of the single ion detector using MCP in heavy ion microbeam device, the response of MCP to single heavy ion, the response of a superheated liquid drop type detector to low LET radiation, the response characteristics of a CR-39 flight track detector to hydrogen isotopes, the analysis of small nuclear flight tracks on CR-39 with an interatomic force microscope, charge-sensible amplifiers, the signal-processing circuit for position detection, time and depth-resolved measurement of ion tracks in condensed matter, the response of a thin Si detector to electrons, the method of expressing gas-amplifying rate curves in proportional count gas for low temperature, the characteristics of self annihilating streamer by ultraviolet laser, the development of slow positron beam using radioisotopes, the development of a tunnel junction type x-ray detector, the development of the pattern-analyzing system for PIXE spectra, the characteristics of NE213-CaF 2 bond type neutron detector and many others. In this report, the gists of these papers are collected. (K.I.)

  11. Supralinear detectors in neutron dosimetry

    International Nuclear Information System (INIS)

    Larsson, L.; Roth, R.A.; Katz, R.

    1977-01-01

    Dose-response curves for nuclear emulsions exposed to x-rays and neutrons are presented and discussed. Ilford K.5 plates were used to mimic an initial slope model of biological cell survival curves, and Ilford K-2.5 plates were used to mimic the multi-target survival model after gamma-ray irradiation. The plates were exposed to x-rays from a Torrex-150 x-ray unit and fission neutrons at the 18 kW Triga Mark I reactor. Representative calculations for the response of model detectors to 14 MeV neutrons were made for comparison with experimental findings. Results are presented and discussed

  12. Transmutation detectors

    Energy Technology Data Exchange (ETDEWEB)

    Viererbl, L., E-mail: vie@ujv.c [Research Centre Rez Ltd. (Czech Republic); Nuclear Research Institute Rez plc (Czech Republic); Lahodova, Z. [Research Centre Rez Ltd. (Czech Republic); Nuclear Research Institute Rez plc (Czech Republic); Klupak, V. [Nuclear Research Institute Rez plc (Czech Republic); Sus, F. [Research Centre Rez Ltd. (Czech Republic); Nuclear Research Institute Rez plc (Czech Republic); Kucera, J. [Research Centre Rez Ltd. (Czech Republic); Nuclear Physics Institute, Academy of Sciences of the Czech Republic (Czech Republic); Kus, P.; Marek, M. [Research Centre Rez Ltd. (Czech Republic); Nuclear Research Institute Rez plc (Czech Republic)

    2011-03-11

    We have designed a new type of detectors, called transmutation detectors, which can be used primarily for neutron fluence measurement. The transmutation detector method differs from the commonly used activation detector method in evaluation of detector response after irradiation. Instead of radionuclide activity measurement using radiometric methods, the concentration of stable non-gaseous nuclides generated by transmutation in the detector is measured using analytical methods like mass spectrometry. Prospective elements and nuclear reactions for transmutation detectors are listed and initial experimental results are given. The transmutation detector method could be used primarily for long-term measurement of neutron fluence in fission nuclear reactors, but in principle it could be used for any type of radiation that can cause transmutation of nuclides in detectors. This method could also be used for measurement in accelerators or fusion reactors.

  13. Transmutation detectors

    International Nuclear Information System (INIS)

    Viererbl, L.; Lahodova, Z.; Klupak, V.; Sus, F.; Kucera, J.; Kus, P.; Marek, M.

    2011-01-01

    We have designed a new type of detectors, called transmutation detectors, which can be used primarily for neutron fluence measurement. The transmutation detector method differs from the commonly used activation detector method in evaluation of detector response after irradiation. Instead of radionuclide activity measurement using radiometric methods, the concentration of stable non-gaseous nuclides generated by transmutation in the detector is measured using analytical methods like mass spectrometry. Prospective elements and nuclear reactions for transmutation detectors are listed and initial experimental results are given. The transmutation detector method could be used primarily for long-term measurement of neutron fluence in fission nuclear reactors, but in principle it could be used for any type of radiation that can cause transmutation of nuclides in detectors. This method could also be used for measurement in accelerators or fusion reactors.

  14. Monocytes infiltrate the pancreas via the MCP-1/CCR2 pathway and differentiate into stellate cells.

    Directory of Open Access Journals (Sweden)

    Kazuko Ino

    Full Text Available Recent studies have shown that monocytes possess pluripotent plasticity. We previously reported that monocytes could differentiate into hepatic stellate cells. Although stellate cells are also present in the pancreas, their origin remains unclear. An accumulation of enhanced green fluorescent protein (EGFP(+CD45(- cells was observed in the pancreases and livers of chimeric mice, which were transplanted with a single hematopoietic stem cell isolated from EGFP-transgenic mice and treated with carbon tetrachloride (CCl4. Because the vast majority of EGFP(+CD45(- cells in the pancreas expressed stellate cell-associated antigens such as vimentin, desmin, glial fibrillary acidic protein, procollagen-I, and α-smooth muscle actin, they were characterized as pancreatic stellate cells (PaSCs. EGFP(+ PaSCs were also observed in CCl4-treated mice adoptively transferred with monocytes but not with other cell lineages isolated from EGFP-transgenic mice. The expression of monocyte chemoattractant protein-1 (MCP-1 and angiotensin II (Ang II increased in the pancreas of CCl4-treated mice and their respective receptors, C-C chemokine receptor 2 (CCR2 and Ang II type 1 receptor (AT1R, were expressed on Ly6C(high monocytes isolated from EGFP-transgenic mice. We examined the effect of an AT1R antagonist, irbesartan, which is also a CCR2 antagonist, on the migration of monocytes into the pancreas. Monocytes migrated toward MCP-1 but not Ang II in vitro. Irbesartan inhibited not only their in vitro chemotaxis but also in vivo migration of adoptively transferred monocytes from peripheral blood into the pancreas. Irbesartan treatment significantly reduced the numbers of EGFP(+F4/80(+CCR2(+ monocytic cells and EGFP(+ PaSCs in the pancreas of CCl4-treated chimeric mice receiving EGFP(+ bone marrow cells. A specific CCR2 antagonist RS504393 inhibited the occurrence of EGFP(+ PaSCs in injured mice. We propose that CCR2(+ monocytes migrate into the pancreas possibly via the

  15. Insulin resistance is associated with MCP1-mediated macrophage accumulation in skeletal muscle in mice and humans.

    Directory of Open Access Journals (Sweden)

    David Patsouris

    Full Text Available Inflammation is now recognized as a major factor contributing to type 2 diabetes (T2D. However, while the mechanisms and consequences associated with white adipose tissue inflammation are well described, very little is known concerning the situation in skeletal muscle. The aim of this study was to investigate, in vitro and in vivo, how skeletal muscle inflammation develops and how in turn it modulates local and systemic insulin sensitivity in different mice models of T2D and in humans, focusing on the role of the chemokine MCP1. Here, we found that skeletal muscle inflammation and macrophage markers are increased and associated with insulin resistance in mice models and humans. In addition, we demonstrated that intra-muscular TNFα expression is exclusively restricted to the population of intramuscular leukocytes and that the chemokine MCP1 was associated with skeletal muscle inflammatory markers in these models. Furthermore, we demonstrated that exposure of C2C12 myotubes to palmitate elevated the production of the chemokine MCP1 and that the muscle-specific overexpression of MCP1 in transgenic mice induced the local recruitment of macrophages and altered local insulin sensitivity. Overall our study demonstrates that skeletal muscle inflammation is clearly increased in the context of T2D in each one of the models we investigated, which is likely consecutive to the lipotoxic environment generated by peripheral insulin resistance, further increasing MCP1 expression in muscle. Consequently, our results suggest that MCP1-mediated skeletal muscle macrophages recruitment plays a role in the etiology of T2D.

  16. Parallel Plate Chambers and their possible use in LHC experiments

    International Nuclear Information System (INIS)

    Arefiev, A.; Bencze, Gy.L.; Bizzeti, A.; Choumilov, E.; Civinini, C.; D'Alessandro, R.; Dajko, G.; Fenyvesi, A.; Ferrando, A.; Fouz, M.C.; Iglesias, A.; Ivochkin, V.; Maggi, F.; Malinin, A.; Martinez-Laso, L.; Meschini, M.; Molnar, J.; Pojidaev, V.; Szoncso, F.; Wulz, C.E.

    1995-01-01

    Present status of Parallel Plate Chambers (PPC) is reviewed. After a description of this detector, results from tests concerning PPC efficiency uniformity, radiation hardness, and behaviour in electromagnetic calorimetry are presented. Some possible utilizations in LHC experiments are mentioned. (orig.)

  17. INDIA: Photon multiplicity detector

    International Nuclear Information System (INIS)

    Anon.

    1995-01-01

    Full text: The team of Indian scientists from Calcutta's Variable Energy Cyclotron Centre, Bhubaneswar Institute of Physics, Panjab (Chandigarh), Rajasthan (Jaipur) and Jammu in collaboration with GSI Darmstadt have contributed a large and highly granular preshower photon multiplicity detector (PMD) for the WA98 experiment at the CERN SPS proton synchrotron. This experiment studies high energy collisions of lead ions and will measure both charged particle and photon multiplicity in a large overlap region. The motivation for measuring photon multiplicity in ultra-relativistic heavy ion collisions stems from theoretical predictions of changes in the relative production of photons and charged particles in the phase transition of hadronic matter to quarkgluon plasma and its subsequent hadronization. The photon multiplicity detector consists of a matrix of scintillator pads placed in light-tight boxes and mounted behind the lead converter plates. The light from the scintillator pads is transported to the readout system using wavelength shifting (WLS) fibres. Developing on the team's earlier experience with a smaller version for the WA93 experiment (September 1991, page 16), several modifications were incorporated to improve light collection and transport. Use of improved WLS fibres, short WLS pieces to minimize self-absorption, and thermal splicing with long clear fibres were some of the important changes incorporated. Tests showed signficantly improved light collection. The scintillator pads were fabricated at all the five collaborating centres in India and the complicated assembly in the detector box modules carried out at the Variable Energy Cyclotron Centre, Calcutta. More than 400 lead converter plates were machined in Calcutta to rigorous tolerances of 0.2 mm. The assembled detector box modules and lead plates were shipped to CERN in spring 1994 for tests and installation. The WA98 PMD consists of over 50,000 scintillator pads of sizes varying from 15 to

  18. INDIA: Photon multiplicity detector

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    1995-01-15

    Full text: The team of Indian scientists from Calcutta's Variable Energy Cyclotron Centre, Bhubaneswar Institute of Physics, Panjab (Chandigarh), Rajasthan (Jaipur) and Jammu in collaboration with GSI Darmstadt have contributed a large and highly granular preshower photon multiplicity detector (PMD) for the WA98 experiment at the CERN SPS proton synchrotron. This experiment studies high energy collisions of lead ions and will measure both charged particle and photon multiplicity in a large overlap region. The motivation for measuring photon multiplicity in ultra-relativistic heavy ion collisions stems from theoretical predictions of changes in the relative production of photons and charged particles in the phase transition of hadronic matter to quarkgluon plasma and its subsequent hadronization. The photon multiplicity detector consists of a matrix of scintillator pads placed in light-tight boxes and mounted behind the lead converter plates. The light from the scintillator pads is transported to the readout system using wavelength shifting (WLS) fibres. Developing on the team's earlier experience with a smaller version for the WA93 experiment (September 1991, page 16), several modifications were incorporated to improve light collection and transport. Use of improved WLS fibres, short WLS pieces to minimize self-absorption, and thermal splicing with long clear fibres were some of the important changes incorporated. Tests showed signficantly improved light collection. The scintillator pads were fabricated at all the five collaborating centres in India and the complicated assembly in the detector box modules carried out at the Variable Energy Cyclotron Centre, Calcutta. More than 400 lead converter plates were machined in Calcutta to rigorous tolerances of 0.2 mm. The assembled detector box modules and lead plates were shipped to CERN in spring 1994 for tests and installation. The WA98 PMD consists of over 50,000 scintillator pads of sizes varying from 15 to 25 mm

  19. Plasma cytokines eotaxin, MIP-1α, MCP-4, and vascular endothelial growth factor in acute lower respiratory tract infection

    DEFF Research Database (Denmark)

    Relster, Mette Marie; Holm, Anette; Pedersen, Court

    2017-01-01

    ), monocyte chemoattractant protein 4 (MCP-4), and vascular endothelial growth factor (VEGF) in 40 patients hospitalized with acute lower respiratory tract infections (LRTI). The cytokines contribute to the pathogenesis of several inflammatory respiratory diseases, indicating a potential as markers for LRTI....... Patients were stratified according to etiology and severity of LRTI, based on baseline C-reactive protein and CURB-65 scores. Using a multiplex immunoassay of plasma, levels of eotaxin and MCP-4 were shown to increase from baseline until day 6 after admission to hospital. The four cytokines were unable...

  20. Intermittent pneumatic leg compressions acutely upregulate VEGF and MCP-1 expression in skeletal muscle.

    Science.gov (United States)

    Roseguini, Bruno T; Mehmet Soylu, S; Whyte, Jeffrey J; Yang, H T; Newcomer, Sean; Laughlin, M Harold

    2010-06-01

    Application of intermittent pneumatic compressions (IPC) is an extensively used therapeutic strategy in vascular medicine, but the mechanisms by which this method works are unclear. We tested the hypothesis that acute application (150 min) of cyclic leg compressions in a rat model signals upregulation of angiogenic factors in skeletal muscle. To explore the impact of different pressures and frequency of compressions, we divided rats into four groups as follows: 120 mmHg (2 s inflation/2 s deflation), 200 mmHg (2 s/2 s), 120 mmHg (4 s/16 s), and control (no intervention). Blood flow and leg oxygenation (study 1) and the mRNA expression of angiogenic mediators in the rat tibialis anterior muscle (study 2) were assessed after a single session of IPC. In all three groups exposed to the intervention, a modest hyperemia (approximately 37% above baseline) between compressions and a slight, nonsignificant increase in leg oxygen consumption (approximately 30%) were observed during IPC. Compared with values in the control group, vascular endothelial growth factor (VEGF) and monocyte chemotactic protein-1 (MCP-1) mRNA increased significantly (P < 0.05) only in rats exposed to the higher frequency of compressions (2 s on/2 s off). Endothelial nitric oxide synthase, matrix metalloproteinase-2, and hypoxia-inducible factor-1alpha mRNA did not change significantly following the intervention. These findings show that IPC application augments the mRNA content of key angiogenic factors in skeletal muscle. Importantly, the magnitude of changes in mRNA expression appeared to be modulated by the frequency of compressions such that a higher frequency (15 cycles/min) evoked more robust changes in VEGF and MCP-1 compared with a lower frequency (3 cycles/min).

  1. Position-sensitive X-ray detectors

    International Nuclear Information System (INIS)

    Hendrix, J.

    1982-01-01

    An overview is given of the different types of position-sensitive X-ray detectors used in kinetic studies of biological molecule state changes using X-ray diffraction with synchrotron radiation as a probe. The detector requirements and principles of operation of proportional counters are outlined. Multiwire proportional chamber systems and their readout techniques are described. Other detectors discussed include a drift chamber type detector, microchannel plates, charge-couple devices and, for high count rates, an integrating TV-detector. (U.K.)

  2. Detector Unit

    CERN Multimedia

    1960-01-01

    Original detector unit of the Instituut voor Kernfysisch Onderzoek (IKO) BOL project. This detector unit shows that silicon detectors for nuclear physics particle detection were already developed and in use in the 1960's in Amsterdam. Also the idea of putting 'strips' onto the silicon for high spatial resolution of a particle's impact on the detector were implemented in the BOL project which used 64 of these detector units. The IKO BOL project with its silicon particle detectors was designed, built and operated from 1965 to roughly 1977. Detector Unit of the BOL project: These detectors, notably the ‘checkerboard detector’, were developed during the years 1964-1968 in Amsterdam, The Netherlands, by the Natuurkundig Laboratorium of the N.V. Philips Gloeilampen Fabrieken. This was done in close collaboration with the Instituut voor Kernfysisch Onderzoek (IKO) where the read-out electronics for their use in the BOL Project was developed and produced.

  3. Detector trends

    International Nuclear Information System (INIS)

    Charpak, G.

    1986-01-01

    The author describes briefly the development of detectors for high energy physics experiments. Especially considered are semiconductor microstrip detectors, drift tubes, holographic bubble chambers, scintillating fiber optics, and calorimeters. (HSI).

  4. Photon counting with small pore microchannel plates

    International Nuclear Information System (INIS)

    Martindale, A.; Lapington, J.S.; Fraser, G.W.

    2007-01-01

    We describe the operation of microchannel plates (MCPs) with 3.2μm diameter channels as photon counting detectors of soft X-rays. Gain and temporal resolution measurements are compared with theoretical scaling laws for channel diameter. A minimum pulse width of 264ps is observed for a two stage multiplier at a total bias voltage of ∼1930V

  5. Infrared detectors

    CERN Document Server

    Rogalski, Antonio

    2010-01-01

    This second edition is fully revised and reorganized, with new chapters concerning third generation and quantum dot detectors, THz detectors, cantilever and antenna coupled detectors, and information on radiometry and IR optics materials. Part IV concerning focal plane arrays is significantly expanded. This book, resembling an encyclopedia of IR detectors, is well illustrated and contains many original references … a really comprehensive book.-F. Sizov, Institute of Semiconductor Physics, National Academy of Sciences, Kiev, Ukraine

  6. Variation of microchannel plate resistance with temperature and applied voltage

    International Nuclear Information System (INIS)

    Pearson, J.F.; Fraser, G.W.; Whiteley, M.J.

    1987-01-01

    The resistance of microchannel plate electron multiplier is well known to be a function of both applied voltage and detector temperature. We show that the apparent variation of resistance with bias voltage is simply due to plate temperature increases resulting from resistive heating. (orig.)

  7. Changes in quality and biochemical parameters in 'Idared' apples during prolonged shelf life and 1-MCP treatment.

    Science.gov (United States)

    Bizjak, Jan; Slatnar, Ana; Stampar, Franci; Veberic, Robert

    2012-12-01

    In this study, changes in quality and various biochemical parameters of 'Idared' apples during prolonged shelf life period after ultra-low oxygen (ULO) storage were investigated. Additionally, the impact of the postharvest application of 1-methylcyclopropene (1-MCP) on different parameters was evaluated. After the harvest, apples were stored in the ULO storage for 6 months and then exposed to room temperature. Fruit firmness, peel color, and changes in sugars, organic acids and phenolics were monitored during the 3 weeks of shelf life. Malic acid, sugars and firmness decreased at room temperature. However, the color of the apples remained unchanged. The level of citric and ascorbic acid remained constant. Levels of phenolics in the peel increased significantly, whereas remained constant in the pulp of apples. 1-MCP treatment resulted in higher amounts of fructose and glucose, malic acid and greater firmness of apples. However, 1-MCP did not influence the phenolic content, ascorbic acid or color. The results obtained indicate that the content of different health-promoting compounds of apples does not change dramatically at room temperature. At the same time these results suggest that 1-MCP could be useful for maintaining certain quality and biochemical parameters and might extend the shelf life of apples.

  8. The association between MCP-1, VEGF polymorphisms and their serum levels in patients with diabetic foot ulcer.

    Science.gov (United States)

    Li, Xiaolei

    2018-06-01

    The purpose of the present study was to investigate distribution of monocyte chemoattractant protein-1 (MCP-1) -2518A/G and vascular endothelial growth factor (VEGF) -634G/C polymorphisms in type 2 diabetes melitus patients (T2DM) presenting diabetic foot ulcer (DFU). Additionally, we evaluated the effects of these 2 polymorphisms on serum levels of MCP-1 and VEGF in the study population.Patients diagnosed with T2DM without or with DFU were recruited in the study. The distribution of MCP-1 -2518A/G and VEGF -634G/C polymorphisms was investigated by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Enzyme-linked immunosorbent assay (ELISA) was applied to detect the protein levels of MCP-1 and VEGF. The comparisons of protein levels in DFU patients were performed by student t test according to their genotypes.The frequencies of GG genotype and G allele of MCP-1 -2518A/G was increased in DFU patients, compared with T2DM patients (odds ratio [OR] = 2.60, 95% confidence interval [CI] = 1.23-5.50, P = .011 and OR = 1.72, 95% CI = 1.18-2.50, P = .005, respectively). Moreover, the increased frequency of GG was significantly associated with up-regulated MCP-1 level in DFU patients (P < .001). Analysis for VEGF -634G/C polymorphisms indicated that the prevalence of CC genotype and C allele of the polymorphisms was decreased in DFU patients, compared with T2DM patients (OR = 0.36, 95% CI = 0.17-0.77, P = .008 and OR = 0.63, 95% CI = 0.43-0.91, P = .015, respectively). DFU patients carrying CC genotype had a higher level of VEGF than those with other genotypes (P = .007).MCP-1 -2518A/G and VEGF -634G/C polymorphisms may involve in occurrence and progress of DFU through regulating transcription activity of the genes.

  9. Controlled atmosphere pO2 alters ripening dynamics of 1-MCP treated ‘d’Anjou’ pear (Pyrus communis L.) fruit

    Science.gov (United States)

    Ripening and development of physiological disorders and decay were assessed in ‘d’Anjou’ pear fruit following 1-methylcyclopropene (1-MCP) treatment and cold storage in air or controlled atmosphere (CA). Fruit were exposed after harvest to 0 or 12.6 µmol•L-1 1-MCP and then stored at 0.5 oC in air o...

  10. Combination of IL-6, IL-10, and MCP-1 with traditional serum tumor markers in lung cancer diagnosis and prognosis.

    Science.gov (United States)

    Pan, Y W; Zhou, Z G; Wang, M; Dong, J Q; Du, K P; Li, S; Liu, Y L; Lv, P J; Gao, J B

    2016-11-03

    Early detection and treatment is critically important for lung cancer patients. Inflammatory mediators such as IL-6, IL-10, and MCP-1 participate in lung cancer regulation. CEA, CA125, and ProGRP are commonly used serum tumor markers for lung cancer. In this study, we assessed the sensitivity and specificity of CEA, CA125, and ProGRP when used in combination with IL-6, IL-10, and MCP in lung cancer diagnosis. Serum from three different groups (healthy controls, individuals with high risk for lung cancer, and lung cancer patients) was collected. Electrochemiluminescence was used to detect expressions of CEA, CA125, and ProGRP; ELISA was used to examine serum levels of IL-6, IL-10, and MCP-1. Specificity and sensitivity of single as well as combination markers in lung cancer diagnosis were determined. Results indicated that CEA, CA125, ProGRP, and MCP-1 were significantly up-regulated in lung cancer patients as compared to those in controls and high risk individuals. Higher IL-6 and IL-10 levels were observed in both lung cancer patients and high-risk individuals as compared to those in controls. Highest sensitivity (95.2%) in cancer diagnosis was achieved when all six markers were used. This was followed by a combination of IL-6, IL-10, CEA, CA125, and ProGRP (92.6%). The most sensitive (88.6%). Four-marker combination was composed of IL-6, CEA, CA125, and ProGRP. As the combined usage of CEA, CA125, ProGRP, IL-6, IL-10, and MCP-1 significantly improved sensitivity of lung cancer detection; this biomarker arrangement may be beneficial for early diagnosis, treatment, and prognosis of lung cancer.

  11. Effect of DPA and 1-MCP on chemical compounds related to superficial scald of Granny Smith apples

    Energy Technology Data Exchange (ETDEWEB)

    Moggia, C.; Moya-Leon, M. A.; Pereira, M.; Yuri, J. A.; Lobos, G. A.

    2010-07-01

    Research was carried out to study the mode of action of diphenylamine (DPA) and 1-methylcyclopropene (1-MCP), on control of superficial scald of Granny Smith apples (Malus domestica Borkh.), and its relation with chemical compounds. Fruit was harvested from a commercial orchard in Chile, 182 and 189 days after full bloom and received the following treatments: DPA (2,000 ppm); 1-MCP (1.2 ppm) and control (no treatment). All fruit was stored for 4 or 6 months at 0 degree centigrade. A completely randomized factorial design was used (2 harvest dates by 3 post harvest treatments). Monthly measurements were made on maturity indices, ethylene production rate (EPR), scald related compounds [a-farnesene (AF), conjugated trienes (CT), total anti-oxidants (AO)], and cell membrane stability. Following 4 and 6 months of storage, plus 7 days at 20 degree centigrade, scald was evaluated. After 6 months, DPA-treated fruit, from both harvests, showed similar firmness, EPR and AO, compared to the control. However, AF and CT were lower, and cell membrane stability higher. Conversely, 1-MCP-treated fruit showed a noticeable EPR suppression and AF inhibition, along with higher firmness, lower CT and AO, compared to the control and DPA. Furthermore, cell membrane stability was superior to that of the control and similar to that of the DPA. Treated fruit (DPA and 1-MCP) showed an important reduction in scald compared to the control. The effect of 1-MCP on the investigated compounds and the reduction in scald, confirms that ethylene plays a major role on its development. (Author) 50 refs.

  12. MicroCameras and Photometers (MCP) on board the TARANIS satellite

    Science.gov (United States)

    Farges, T.; Hébert, P.; Le Mer-Dachard, F.; Ravel, K.; Gaillac, S.

    2017-12-01

    TARANIS (Tool for the Analysis of Radiations from lightNing and Sprites) is a CNES micro satellite. Its main objective is to study impulsive transfers of energy between the Earth atmosphere and the space environment. It will be sun-synchronous at an altitude of 700 km. It will be launched in 2019 for at least 2 years. Its payload is composed of several electromagnetic instruments in different wavelengths (from gamma-rays to radio waves including optical). TARANIS instruments are currently in calibration and qualification phase. The purpose is to present the MicroCameras and Photometers (MCP) design, to show its performances after its recent characterization and at last to discuss the scientific objectives and how we want to answer it with the MCP observations. The MicroCameras, developed by Sodern, are dedicated to the spatial description of TLEs and their parent lightning. They are able to differentiate sprite and lightning thanks to two narrow bands ([757-767 nm] and [772-782 nm]) that provide simultaneous pairs of images of an Event. Simulation results of the differentiation method will be shown. After calibration and tests, the MicroCameras are now delivered to the CNES for integration on the payload. The Photometers, developed by Bertin Technologies, will provide temporal measurements and spectral characteristics of TLEs and lightning. There are key instrument because of their capability to detect on-board TLEs and then switch all the instruments of the scientific payload in their high resolution acquisition mode. Photometers use four spectral bands in the [170-260 nm], [332-342 nm], [757-767 nm] and [600-900 nm] and have the same field of view as cameras. The on-board TLE detection algorithm remote-controlled parameters have been tuned before launch using the electronic board and simulated or real events waveforms. After calibration, the Photometers are now going through the environmental tests. They will be delivered to the CNES for integration on the

  13. Television area detectors

    International Nuclear Information System (INIS)

    Arndt, V.W.

    1977-01-01

    This paper discusses the use of standard television camera tubes as X-ray detectors in X-ray diffraction studies. Standard tubes can be modified to detect X rays by depositing an external X-ray phosphor on the fibre optics face plate either of a highly sensitive television camera tube or of an image intensifier coupled to a camera tube. The author considers various X-ray phosphors and concludes that polycrystalline silver activated ZnS is most suitable for crystallographic applications. In the following sections various types of television camera tubes with adequate light sensitivity for use in an X-ray detection system are described, and also three types of image intensifiers. The digitization of the television output signals and their statistical precision are discussed and the electronic circuitry for the detector system is briefly described. (B.D.)

  14. The MCP Altona incident: the Canadian regulatory response and framework for the export of uranium

    International Nuclear Information System (INIS)

    Lavoie, Jacques

    2012-01-01

    On 23 December 2010, a cargo ship carrying 350 000 kilograms (kg) of uranium ore concentrates (U 3 O 8 ) belonging to the Canadian resource corporation Cameco left Vancouver, British Columbia, Canada and encountered severe weather conditions between Hawaii and the Midway Islands in international waters en route to Zhanjiang, People's Republic of China (PRC). The ship, the MCP Altona, suffered some damage to its hull but was able to continue to operate through the storm. Once the sea had calmed, the crew noticed that some of the containers on the ship had shifted and had been damaged. The captain, however, was unable to secure the necessary authorizations to obtain safe harbour in the area as there were no signs of immediate risk to the health and safety of the ship's crew. On Cameco's recommendation, the ship returned to British Columbia. This article describes the response of the Canadian Nuclear Safety Commission (CNSC) to this incident. The article also discusses the Canadian policy and regulatory framework for controls on the export of uranium

  15. A novel ZVS high voltage power supply for micro-channel plate photomultiplier tubes

    Energy Technology Data Exchange (ETDEWEB)

    Pei, Chengquan [Key Laboratory for Physical Electronics and Devices of the Ministry of Education, Xi' an Jiaotong University, Xi’an 710049 (China); Tian, Jinshou [Xi’an Institute of Optics and Precision Mechanics, Chinese Academy of Sciences, Xi' an 710119 (China); Liu, Zhen [Key Laboratory for Physical Electronics and Devices of the Ministry of Education, Xi' an Jiaotong University, Xi’an 710049 (China); Qin, Hong [School of Computer Science and Technology, Xi' an University of Science and Technology, Xi' an 710054 (China); Wu, Shengli, E-mail: slwu@mail.xjtu.edu.cn [Key Laboratory for Physical Electronics and Devices of the Ministry of Education, Xi' an Jiaotong University, Xi’an 710049 (China)

    2017-04-11

    A novel resonant high voltage power supply (HVPS) with zero voltage switching (ZVS), to reduce the voltage stress on switching devices and improve conversion efficiency, is proposed. The proposed HVPS includes a drive circuit, a transformer, several voltage multiplying circuits, and a regulator circuit. The HVPS contains several secondary windings that can be precisely regulated. The proposed HVPS performed better than the traditional resistor voltage divider, which requires replacing matching resistors resulting in resistor dispersibility in the Micro-Channel Plate (MCP). The equivalent circuit of the proposed HVPS was established and the operational principle analyzed. The entire switching element can achieve ZVS, which was validated by a simulation and experiments. The properties of this HVPS were tested including minimum power loss (240 mW), maximum power loss (1 W) and conversion efficiency (85%). The results of this research are that the proposed HVPS was suitable for driving the micro-channel plate photomultiplier tube (MCP-PMT). It was therefore adopted to test the MCP-PMT, which will be used in Daya Bay reactor neutrino experiment II in China.

  16. A novel ZVS high voltage power supply for micro-channel plate photomultiplier tubes

    International Nuclear Information System (INIS)

    Pei, Chengquan; Tian, Jinshou; Liu, Zhen; Qin, Hong; Wu, Shengli

    2017-01-01

    A novel resonant high voltage power supply (HVPS) with zero voltage switching (ZVS), to reduce the voltage stress on switching devices and improve conversion efficiency, is proposed. The proposed HVPS includes a drive circuit, a transformer, several voltage multiplying circuits, and a regulator circuit. The HVPS contains several secondary windings that can be precisely regulated. The proposed HVPS performed better than the traditional resistor voltage divider, which requires replacing matching resistors resulting in resistor dispersibility in the Micro-Channel Plate (MCP). The equivalent circuit of the proposed HVPS was established and the operational principle analyzed. The entire switching element can achieve ZVS, which was validated by a simulation and experiments. The properties of this HVPS were tested including minimum power loss (240 mW), maximum power loss (1 W) and conversion efficiency (85%). The results of this research are that the proposed HVPS was suitable for driving the micro-channel plate photomultiplier tube (MCP-PMT). It was therefore adopted to test the MCP-PMT, which will be used in Daya Bay reactor neutrino experiment II in China.

  17. Detailed measurements and shaping of gate profiles for microchannel-plate-based X-ray framing cameras

    International Nuclear Information System (INIS)

    Landen, O.L.; Hammel, B.A.; Bell, P.M.; Abare, A.; Bradley, D.K.; Univ. of Rochester, NY

    1994-01-01

    Gated, microchannel-plate-based (MCP) framing cameras are increasingly used worldwide for x-ray imaging of subnanosecond laser-plasma phenomena. Large dynamic range (> 1,000) measurements of gain profiles for gated microchannel plates (MCP) are presented. Temporal profiles are reconstructed for any point on the microstrip transmission line from data acquired over many shots with variable delay. No evidence for significant pulse distortion by voltage reflections at the ends of the microstrip is observed. The measured profiles compare well to predictions by a time-dependent discrete dynode model down to the 1% level. The calculations do overestimate the contrast further into the temporal wings. The role of electron transit time dispersion in limiting the minimum achievable gate duration is then investigated by using variable duration flattop gating pulses. A minimum gate duration of 50 ps is achieved with flattop gating, consistent with a fractional transit time spread of ∼ 15%

  18. Radiation shielding plate

    International Nuclear Information System (INIS)

    Kobayashi, Torakichi; Sugawara, Takeo.

    1983-01-01

    Purpose: To reduce the weight and stabilize the configuration of a radiation shielding plate which is used in close contact with an object to be irradiated with radiation rays. Constitution: The radiation shielding plate comprises a substrate made of lead glass and a metallic lead coating on the surface of the substrate by means of plating, vapor deposition or the like. Apertures for permeating radiation rays are formed to the radiation shielding plate. Since the shielding plate is based on a lead glass plate, a sufficient mechanical strength can be obtained with a thinner structure as compared with the conventional plate made of metallic lead. Accordingly, if the shielding plate is disposed on a soft object to be irradiated with radiation rays, the object and the plate itself less deform to obtain a radiation irradiation pattern with distinct edges. (Moriyama, K.)

  19. Ação do 1-metilciclopropeno (1-MCP na vida de prateleira da banana 'maçã' Action of 1-methylcyclopropene (1-MCP on shelf life of 'apple' banana

    Directory of Open Access Journals (Sweden)

    Ana Carla Marques Pinheiro

    2005-04-01

    Full Text Available Objetivou-se avaliar o efeito do 1-metilciclopropeno (1-MCP, em diferentes concentrações, sobre a vida pós-colheita e sob as variáveis associadas aos atributos de qualidade de banana 'Maçã'. Frutos verde-maturos foram submetidos a cinco concentrações de 1-MCP (0; 50; 100; 150 e 200 etaL.L-1, por 12 horas, e foram analisados durante o amadurecimento sob condição ambiente (20±1ºC e 80±5% UR. O tratamento com 50 etaL.L-1 de 1-MCP atrasou o início do amadurecimento das bananas em aproximadamente 8 dias, baseando-se nas primeiras mudanças de coloração da casca, enquanto os tratamentos 100; 150 e 200 etaL.L-1 atrasaram-no em aproximadamente 10 dias. Observou-se, durante o amadurecimento, o amaciamento dos frutos, associado à conversão de amido em açúcares e ao aumento na solubilização péctica e na atividade da pectinametilesterase (PME e poligalacturonase (PG. A aplicação de 50 etaL.L-1de 1-MCP é a mais adequada por promover a extensão da vida de prateleira de bananas 'Maçã', preservando sua qualidade com base nas análises de açúcares solúveis totais, pectinas total e solúvel, firmeza e aparência externa ao final do armazenamento.The objective of this work was to evaluate the influence of the 1-MCP, at different concentrations, on quality and shelf life of 'Apple' banana. Green mature fruits were submitted to five concentrations of 1-MCP (0, 50, 100, 150 and 200 etaL.L-1, for 12 hours and analyzed during the ripening at room temperature (20ºC ± 1 and 80% ± 5 RH . The 1-MCP at 50 etaL.L-1 delayed, in 8 days, the begining of the ripening, based in the first changes of peel color, whereas 100, 150 and 200 etaL.L-1 treatments delayed the begining of the ripening in 10 days, in comparison to the control. The softening of the fruits, associated to the conversion of starch in sugar and the increasing in the pectic solubilization and activity of pectinmethylsterase and polygalacturonase, was observed during the ripening

  20. The BABAR Detector

    Energy Technology Data Exchange (ETDEWEB)

    Luth, Vera G

    2001-05-18

    BABAR, the detector for the SLAC PEP-II asymmetric e{sup +}e{sup -} B Factory operating at the {Upsilon}(4S) resonance, was designed to allow comprehensive studies of CP-violation in B-meson decays. Charged particle tracks are measured in a multi-layer silicon vertex tracker surrounded by a cylindrical wire drift chamber. Electromagentic showers from electrons and photons are detected in an array of CsI crystals located just inside the solenoidal coil of a superconducting magnet. Muons and neutral hadrons are identified by arrays of resistive plate chambers inserted into gaps in the steel flux return of the magnet. Charged hadrons are identified by dE/dx measurements in the tracking detectors and in a ring-imaging Cherenkov detector surrounding the drift chamber. The trigger, data acquisition and data-monitoring systems, VME- and network-based, are controlled by custom-designed online software. Details of the layout and performance of the detector components and their associated electronics and software are presented.

  1. First ALICE detectors installed!

    CERN Multimedia

    2006-01-01

    Detectors to track down penetrating muon particles are the first to be placed in their final position in the ALICE cavern. The Alice muon spectrometer: in the foreground the trigger chamber is positioned in front of the muon wall, with the dipole magnet in the background. After the impressive transport of its dipole magnet, ALICE has begun to fill the spectrometer with detectors. In mid-July, the ALICE muon spectrometer team achieved important milestones with the installation of the trigger and the tracking chambers of the muon spectrometer. They are the first detectors to be installed in their final position in the cavern. All of the eight half planes of the RPCs (resistive plate chambers) have been installed in their final position behind the muon filter. The role of the trigger detector is to select events containing a muon pair coming, for instance, from the decay of J/ or Y resonances. The selection is made on the transverse momentum of the two individual muons. The internal parts of the RPCs, made o...

  2. Crystallization and crystallographic analysis of the ligand-binding domain of the Pseudomonas putida chemoreceptor McpS in complex with malate and succinate

    International Nuclear Information System (INIS)

    Gavira, J. A.; Lacal, J.; Ramos, J. L.; García-Ruiz, J. M.; Krell, T.; Pineda-Molina, E.

    2012-01-01

    The crystallization of the ligand-binding domain of the methyl-accepting chemotaxis protein chemoreceptor McpS (McpS-LBD) is reported. Methyl-accepting chemotaxis proteins (MCPs) are transmembrane proteins that sense changes in environmental signals, generating a chemotactic response and regulating other cellular processes. MCPs are composed of two main domains: a ligand-binding domain (LBD) and a cytosolic signalling domain (CSD). Here, the crystallization of the LBD of the chemoreceptor McpS (McpS-LBD) is reported. McpS-LBD is responsible for sensing most of the TCA-cycle intermediates in the soil bacterium Pseudomonas putida KT2440. McpS-LBD was expressed, purified and crystallized in complex with two of its natural ligands (malate and succinate). Crystals were obtained by both the counter-diffusion and the hanging-drop vapour-diffusion techniques after pre-incubation of McpS-LBD with the ligands. The crystals were isomorphous and belonged to space group C2, with two molecules per asymmetric unit. Diffraction data were collected at the ESRF synchrotron X-ray source to resolutions of 1.8 and 1.9 Å for the malate and succinate complexes, respectively

  3. Technical Note: Scanning of parallel-plate ionization chamber and diamond detector for measurements of water-dose profiles in the vicinity of a narrow x-ray microbeam.

    Science.gov (United States)

    Nariyama, Nobuteru

    2017-12-01

    Scanning of dosimeters facilitates dose distribution measurements with fine spatial resolutions. This paper presents a method of conversion of the scanning results to water-dose profiles and provides an experimental verification. An Advanced Markus chamber and a diamond detector were scanned at a resolution of 6 μm near the beam edges during irradiation with a 25-μm-wide white narrow x-ray beam from a synchrotron radiation source. For comparison, GafChromic films HD-810 and HD-V2 were also irradiated. The conversion procedure for the water dose values was simulated with Monte Carlo photon-electron transport code as a function of the x-ray incidence position. This method was deduced from nonstandard beam reference-dosimetry protocols used for high-energy x-rays. Among the calculated nonstandard beam correction factors, P wall , which is the ratio of the absorbed dose in the sensitive volume of the chamber with water wall to that with a polymethyl methacrylate wall, was found to be the most influential correction factor in most conditions. The total correction factor ranged from 1.7 to 2.7 for the Advanced Markus chamber and from 1.15 to 1.86 for the diamond detector as a function of the x-ray incidence position. The water dose values obtained with the Advanced Markus chamber and the HD-810 film were in agreement in the vicinity of the beam, within 35% and 18% for the upper and lower sides of the beam respectively. The beam width obtained from the diamond detector was greater, and the doses out of the beam were smaller than the doses of the others. The comparison between the Advanced Markus chamber and HD-810 revealed that the dose obtained with the scanned chamber could be converted to the water dose around the beam by applying nonstandard beam reference-dosimetry protocols. © 2017 American Association of Physicists in Medicine.

  4. Correlation of MCP-4 and high-sensitivity C-reactive protein as a marker of inflammation in obesity and chronic periodontitis.

    Science.gov (United States)

    Pradeep, A R; Kumari, Minal; Kalra, Nitish; Priyanka, N

    2013-03-01

    Obesity is increasing in prevalence worldwide and has emerged as a strong risk factor for periodontal disease. Conversely, the remote effects of periodontal disease on various systemic diseases have been proposed. The aim of this study is to determine the presence of MCP-4 and high sensitivity C reactive protein (hsCRP) levels in gingival crevicular fluid (GCF) and serum in obese and non-obese subjects with chronic periodontitis and to find a correlation between MCP-4 and hsCRP in GCF and serum. Forty subjects (20 males and 20 females) were selected and divided into four groups (10 subjects in each group), based on clinical parameters: group NOH (non-obese healthy), group OH (obese healthy), Group NOCP (non-obese with chronic periodontitis) and group OCP (obese with chronic periodontitis). The levels of serum and GCF MCP-4 were determined by ELISA and hsCRP levels were determined by immunoturbidimetry method. The mean GCF and serum concentration of MCP-4 was highest for group OCP followed by group NOCP, group OH (in GCF); group OH, group NOCP(in serum) and least in group NOH. The mean hsCRP concentration was highest for group OCP followed by group OH, group NOCP and group NOH. A significant positive correlation was found between serum and GCF MCP-4 and hsCRP levels. GCF MCP-4 concentrations increased in periodontal disease compared to health and correlated positively with the severity of disease indicating it as a novel marker of periodontal disease. The serum concentration of MCP-4 was found to be more in obese group as compared to nonobese group indicating it as a marker of obesity. Furthermore, based on the positive correlation of MCP-4 and hsCRP found in this study, it can be proposed that MCP-4 and hsCRP may be the markers linking chronic inflammation in obesity and periodontal disease. Copyright © 2013 Elsevier Ltd. All rights reserved.

  5. Qualidade pós-colheita de quivi 'Hayward' tratado com 1-MCP e armazenado sob diferentes atmosferas

    Directory of Open Access Journals (Sweden)

    Marcelo José Vieira

    2012-06-01

    Full Text Available Este trabalho teve por objetivo avaliar o efeito do 1-MCP sobre o amadurecimento e a qualidade pós-colheita de quivi 'Hayward' armazenado sob diferentes atmosferas. Foram conduzidos dois experimentos, com frutos colhidos em pomar comercial localizado em Fraiburgo-SC. No experimento 1, os frutos foram tratados com três doses de 1-MCP (0,0; 0,5 ou 1,0 µL L-1 e armazenados sob atmosfera controlada (AC, contendo 2,0kPa de O2 + 4,5kPa de CO2, a 0ºC ± 0,5ºC, 92 ± 3% UR, e com <40 ηL L-1 de etileno no ambiente, durante 90 e 120 dias, mais sete dias de vida de prateleira a 23ºC. No experimento 2, os frutos foram tratados com 0,0 ou 0,7 µL L-1 de 1-MCP e armazenados sob atmosfera ambiente (AA, contendo 21 kPa de O2 + 0,03 kPa de CO2, a 0 ± 0,5ºC, 90 ± 3% UR, e com 200 a 250 ηL L-1 de etileno no ambiente, durante 30, 60, 90 e 120 dias, mais um e sete dias de vida de prateleira a 23ºC ou AC (contendo 2,0 kPa de O2 + 4,5 kPa de CO2, a 0ºC ± 0,5ºC, 92 ± 3% UR, e com <40 ηL L-1 de etileno no ambiente, durante 60, 90, 120 e 150 dias, mais um e sete dias de vida de prateleira a 23ºC. Os benefícios do tratamento com 1-MCP sobre a conservação da qualidade foram observados tanto para frutos armazenados sob AA quanto sob AC. No experimento 1, não houve diferença entre as doses de 1-MCP de 0,5 e 1,0 µL L-1 sobre o controle do amadurecimento e manutenção da qualidade dos frutos armazenados em AC. No experimento 2, o tratamento com 1-MCP retardou o aumento na taxa de produção de etileno após remoção de câmara fria. A redução da taxa de produção de etileno nos frutos tratados com 1-MCP foi associada ao aumento na conservação da firmeza da polpa sob AC e AA, e redução na incidência de pericarpo translúcido sob AA. O potencial de armazenamento foi aumentado pelo tratamento com 1-MCP em aproximadamente 60 e 30 dias, nos frutos armazenados sob AA e AC, respectivamente.

  6. EFECTO DEL 1-METILCICLOPROPENO (1-MCP SOBRE LA FISIOLOGÍA Y CALIDAD DE FRUTOS DE JACA (Artocarpus heterophyllus Lam.

    Directory of Open Access Journals (Sweden)

    M. Mata-Montes de Oca

    2007-01-01

    Full Text Available Debido a sus características de color y sabor de pulpa, la demanda de fruta de jaca se ha incrementado considerablemente. La mayoría de la producción de Nayarit es exportada a los Estados Unidos de Norteamérica. Sin embargo, debido a su corta vida de anaquel y susceptibilidad al daño por frío la fruta es exportada vía aérea con altos costos de flete. Se reporta que el 1-Metilciclopropeno (1-MCP retarda el proceso de madurez, alarga la vida de anaquel y mantiene la calidad de varios frutales, así que el objetivo de este estudio fue evaluar el efecto del 1-MCP sobre la fisiología y calidad del fruto de jaca almacenado a 20 ºC. Las frutas fueron cosechadas en madurez fisiológica, lavadas y tratadas con 1-MCP a 100 y 300 nl·litro-1 en cámaras selladas por 12 h a 20 ± 1 ºC; 85 ± 5 % de HR manteniendo un testigo sin tratar. Las variables evaluadas fueron: velocidad de respiración y de producción de etileno, sólidos solubles totales, acidez titulable, firmeza de la pulpa y de la fruta entera, color en la pulpa y pérdida de peso. El 1-MCP no afectó la mayoría de las variables de calidad pero retrasó significativamente la velocidad de respiración y la producción de etileno así como el ablandamiento de la pulpa, lo que permitió prolongar la vida de anaquel hasta por ocho y 12 días a 100 y 300 nl·litro-1, respectivamente.

  7. Aumento da expressão do MCP-1 coroidal e escleral em modelo experimental de hipercolesterolemia

    Directory of Open Access Journals (Sweden)

    Rogil José de Almeida Torres

    2012-02-01

    Full Text Available OBJETIVO: O objetivo deste trabalho é demonstrar experimentalmente que a dieta rica em colesterol provoca aumento da expressão da MCP-1 na coroide e esclera. MÉTODO: Coelhos New Zealand foram organizados em dois grupos: GN (grupo dieta normal, composto por 8 coelhos (8 olhos, recebeu ração padrão para coelhos, durante 4 semanas; GH (grupo hipercolesterolêmico, composto por 13 coelhos (13 olhos, recebeu dieta rica em colesterol a 1% por 8 semanas. Foi realizada a dosagem sérica de colesterol total, triglicerídeos, HDL colesterol, glicemia de jejum no início do experimento e no momento da eutanásia. Ao final da 8ª semana para o GH e 4ª semana para o GN foi realizada a eutanásia dos animais e os olhos foram submetidos à análise imuno-histoquímica com o anticorpo anti-MCP-1. RESULTADOS: A dieta provocou significativo aumento do colesterol total e triglicerídeos do GH em relação ao GN (p<0,001. Houve significativo aumento da expressão da MCP-1 na coroide e esclera dos animais do GH em relação ao GN (p<0,001. CONCLUSÃO: Este estudo demonstrou que a dieta hipercolesterolêmica em coelhos induz ao aumento da expressão do MCP-1 na coroide e esclera.

  8. Create Your Plate

    Medline Plus

    Full Text Available ... foods you want, but changes the portion sizes so you are getting larger portions of non-starchy ... plate. Then on one side, cut it again so you will have three sections on your plate. ...

  9. Create Your Plate

    Medline Plus

    Full Text Available ... of the differences in types of vegetables. When creating your plate at home, remember that half of ... effective for both managing diabetes and losing weight. Creating your plate lets you still choose the foods ...

  10. Create Your Plate

    Medline Plus

    Full Text Available ... Index Low-Calorie Sweeteners Sugar and Desserts Fitness Exercise & Type 1 Diabetes Get Started Safely Get And ... Plate Create Your Plate is a simple and effective way to manage your blood glucose levels and ...

  11. Create Your Plate

    Medline Plus

    Full Text Available ... Meals Diabetes Meal Plans Create Your Plate Gluten Free Diets Meal Planning for Vegetarian Diets Cook with ... Your Plate Meal Planning for Vegetarian Diets Gluten Free Diets Holiday Meal Planning Cook with Heart-Healthy ...

  12. Create Your Plate

    Medline Plus

    Full Text Available ... Your Plate Gluten Free Diets Meal Planning for Vegetarian Diets Cook with Heart-Healthy Foods Holiday Meal ... Healthy Diet Create Your Plate Meal Planning for Vegetarian Diets Gluten Free Diets Holiday Meal Planning Cook ...

  13. Spatially and Temporally Regulated NRF2 Gene Therapy Using Mcp-1 Promoter in Retinal Ganglion Cell Injury

    Directory of Open Access Journals (Sweden)

    Kosuke Fujita

    2017-06-01

    Full Text Available Retinal ganglion cell degeneration triggered by axonal injury is believed to underlie many ocular diseases, including glaucoma and optic neuritis. In these diseases, retinal ganglion cells are affected unevenly, both spatially and temporally, such that healthy and unhealthy cells coexist in different patterns at different time points. Herein, we describe a temporally and spatially regulated adeno-associated virus gene therapy aiming to reduce undesired off-target effects on healthy retinal neurons. The Mcp-1 promoter previously shown to be activated in stressed retinal ganglion cells following murine optic nerve injury was combined with the neuroprotective intracellular transcription factor Nrf2. In this model, Mcp-1 promoter-driven NRF2 expression targeting only stressed retinal ganglion cells showed efficacy equivalent to non-selective cytomegalovirus promoter-driven therapy for preventing cell death. However, cytomegalovirus promoter-mediated NRF2 transcription induced cellular stress responses and death of Brn3A-positive uninjured retinal ganglion cells. Such undesired effects were reduced substantially by adopting the Mcp-1 promoter. Combining a stress-responsive promoter and intracellular therapeutic gene is a versatile approach for specifically targeting cells at risk of degeneration. This strategy may be applicable to numerous chronic ocular and non-ocular conditions.

  14. Resposta da aplicação do 1-MCP em frutos de mamoeiro 'Golden' em diferentes estádios de maturação Responses of 1-MCP applications in 'Golden' papaya fruits on differents maturation stages

    Directory of Open Access Journals (Sweden)

    Maximiliano Silva de Souza

    2009-09-01

    Full Text Available O estudo de fatores que influenciam no processo de amadurecimento é fundamental para o planejamento do processo de comercialização, principalmente em frutos com padrão de respiração climatérico e perecível, como é o caso do mamão. Nesse trabalho, avaliou-se o efeito da aplicação do 1-MCP (1-metilciclopropeno sobre o amadurecimento de frutos de mamoeiro nos estádios 0; 1 e 2 de maturação. O 1-MCP diminui a produção de etileno (≈79% e a taxa respiratória (≈45%, principalmente em frutos no estádio 0 de maturação. O uso deste inibidor da ação do etileno retardou a perda de coloração verde da casca dos frutos, principalmente em frutos nos estádios 0 e 1 de maturação. Houve redução na perda de firmeza do fruto e do mesocarpo nos estádios 1 e 2. Entretanto, em frutos no estádio 0 de maturação, a firmeza do mesocarpo manteve-se alta, o que pode comprometer a aceitação destes frutos pelo consumidor. O teor de sólidos solúveis não foi influenciado pela aplicação do 1-MCP. O efeito do 1-MCP na redução da atividade das enzimas PME e PG foi maior em frutos nos estádios 0 e 1 de maturação em comparação a frutos no estádio 2 de maturação. A atividade da PME demonstrou crescente aumento ao longo do período de armazenamento, porém a atividade da PG permaneceu baixa ao longo dos cinco primeiros dias, com aumento posterior. Os resultados mostraram que a PME exerce influência significativa na perda de firmeza da polpa nos primeiros dias, com atuação posterior da PG. O 1-MCP mostrou-se eficiente em retardar o processo de amadurecimento de frutos de mamoeiro, tornando-se mais eficiente quando associado a estádios de maturação iniciais.The study of factors that influence the process of ripening is critical for planning the marketing process, mainly in standard breathing climacteric and perishing fruits, as it is the case of papaya. In this work it was evaluated the effect of the application of 1-MCP (1

  15. Report of the detector laboratory

    International Nuclear Information System (INIS)

    Lynen, U.; Stelzer, H.; Fischer, B.

    1975-01-01

    Parallel plate detectors with sizes up to 30 x 30 cm 2 have been built and time resolutions of 350 psec for α-particles and approximately 200 psec for 25 MeV 16 O have been obtained. For these detectors a fast preamplifier was developed. Two digital processers for multiplication and division of 13-bit numbers have been built. For a PDP 11/40 a program has been developed which allows the on- and off-line data analysis. (orig.) [de

  16. Cryogenic detectors

    International Nuclear Information System (INIS)

    Zehnder, A.

    1987-01-01

    Presently the development of new large scale detector systems, used in very high energy physics experiments, is very active. In the low energy range, the introduction of charge coupled devices allows improved spacial and energy resolution. In the keV region, high resolution can only be achieved via the well established diffraction spectrometers with the well-known disadvantage of a small throughput. There exist no efficient detectors for non-ionizing radiation such as coherent nuclear scattering of weakly interacting particles. The development of high resolution solid state detectors in the keV-region with the possibility of nuclear recoil detection is therefore highly desired. Such detectors applied in astro and particle physics would thus allow one to obtain new information not achievable otherwise. Three types of cryogenic detectors exist: Calorimeters/Bolometers. This type is sensitive to the produced excess phonons and measures the deposited energy by detecting the heat pulses. Excess charge carriers should be used to produce phonons. Tunneling junctions. This type is sensitive to excess charge produced by the Cooper pair breakup. Excess phonons should be used to break up Cooper pairs. Superheated superconducting granules (SSG). An SSG detector consists of granules, the metastability of which is disturbed by radiation. The Meissner effect then causes a change in the field distribution of the applied external field, which can be detected. The present paper discusses the basic principle of calorimetric and tunneling junction detectors and some of their applications. 26 refs., 7 figs., 1 tab

  17. Hydrogen detector

    International Nuclear Information System (INIS)

    Kumagaya, Hiromichi; Yoshida, Kazuo; Sanada, Kazuo; Chigira, Sadao.

    1994-01-01

    The present invention concerns a hydrogen detector for detecting water-sodium reaction. The hydrogen detector comprises a sensor portion having coiled optical fibers and detects hydrogen on the basis of the increase of light transmission loss upon hydrogen absorption. In the hydrogen detector, optical fibers are wound around and welded to the outer circumference of a quartz rod, as well as the thickness of the clad layer of the optical fiber is reduced by etching. With such procedures, size of the hydrogen detecting sensor portion can be decreased easily. Further, since it can be used at high temperature, diffusion rate is improved to shorten the detection time. (N.H.)

  18. Antifungal activity of 1-methylcyclopropene (1-MCP) against anthracnose (Colletotrichum gloeosporioides) in postharvest mango fruit and its possible mechanisms of action.

    Science.gov (United States)

    Xu, Xiangbin; Lei, Huanhuan; Ma, Xiuyan; Lai, Tongfei; Song, Hongmiao; Shi, Xuequn; Li, Jiangkuo

    2017-01-16

    Anthracnose caused by Colletotrichum gloeosporioides is one of the most important postharvest diseases in mango fruit, often causing huge economic losses. In this study, the effect of 1-methylcyclopropene (1-MCP) against anthracnose in postharvest mango fruit and the mechanisms involved were investigated. 1-MCP induced reactive oxygen species (ROS) generation, damaged the mitochondria and destroyed the integrity of plasma membrane of spores of C. gloeosporioides, significantly suppressing spore germination and mycelial growth of C. gloeosporioides. 1-MCP also decreased the decay incidence and lesion expansion of mango fruit caused by C. gloeosporioides. For the first time this study demonstrated that 1-MCP suppressed anthracnose of postharvest mango fruit by directly inhibiting spore germination and mycelial growth of C. gloeosporioides, thus providing a promising strategy for disease control. Copyright © 2016 Elsevier B.V. All rights reserved.

  19. Paper microzone plates.

    Science.gov (United States)

    Carrilho, Emanuel; Phillips, Scott T; Vella, Sarah J; Martinez, Andres W; Whitesides, George M

    2009-08-01

    This paper describes 96- and 384-microzone plates fabricated in paper as alternatives to conventional multiwell plates fabricated in molded polymers. Paper-based plates are functionally related to plastic well plates, but they offer new capabilities. For example, paper-microzone plates are thin (approximately 180 microm), require small volumes of sample (5 microL per zone), and can be manufactured from inexpensive materials ($0.05 per plate). The paper-based plates are fabricated by patterning sheets of paper, using photolithography, into hydrophilic zones surrounded by hydrophobic polymeric barriers. This photolithography used an inexpensive formulation photoresist that allows rapid (approximately 15 min) prototyping of paper-based plates. These plates are compatible with conventional microplate readers for quantitative absorbance and fluorescence measurements. The limit of detection per zone loaded for fluorescence was 125 fmol for fluorescein isothiocyanate-labeled bovine serum albumin, and this level corresponds to 0.02 the quantity of analyte per well used to achieve comparable signal-to-noise in a 96-well plastic plate (using a solution of 25 nM labeled protein). The limits of detection for absorbance on paper was approximately 50 pmol per zone for both Coomassie Brilliant Blue and Amaranth dyes; these values were 0.4 that required for the plastic plate. Demonstration of quantitative colorimetric correlations using a scanner or camera to image the zones and to measure the intensity of color, makes it possible to conduct assays without a microplate reader.

  20. Pseudogenization of the MCP-2/CCL8 chemokine gene in European rabbit (genus Oryctolagus, but not in species of Cottontail rabbit (Sylvilagus and Hare (Lepus

    Directory of Open Access Journals (Sweden)

    van der Loo Wessel

    2012-08-01

    Full Text Available Abstract Background Recent studies in human have highlighted the importance of the monocyte chemotactic proteins (MCP in leukocyte trafficking and their effects in inflammatory processes, tumor progression, and HIV-1 infection. In European rabbit (Oryctolagus cuniculus one of the prime MCP targets, the chemokine receptor CCR5 underwent a unique structural alteration. Until now, no homologue of MCP-2/CCL8a, MCP-3/CCL7 or MCP-4/CCL13 genes have been reported for this species. This is interesting, because at least the first two genes are expressed in most, if not all, mammals studied, and appear to be implicated in a variety of important chemokine ligand-receptor interactions. By assessing the Rabbit Whole Genome Sequence (WGS data we have searched for orthologs of the mammalian genes of the MCP-Eotaxin cluster. Results We have localized the orthologs of these chemokine genes in the genome of European rabbit and compared them to those of leporid genera which do (i.e. Oryctolagus and Bunolagus or do not share the CCR5 alteration with European rabbit (i.e. Lepus and Sylvilagus. Of the Rabbit orthologs of the CCL8, CCL7, and CCL13 genes only the last two were potentially functional, although showing some structural anomalies at the protein level. The ortholog of MCP-2/CCL8 appeared to be pseudogenized by deleterious nucleotide substitutions affecting exon1 and exon2. By analyzing both genomic and cDNA products, these studies were extended to wild specimens of four genera of the Leporidae family: Oryctolagus, Bunolagus, Lepus, and Sylvilagus. It appeared that the anomalies of the MCP-3/CCL7 and MCP-4/CCL13 proteins are shared among the different species of leporids. In contrast, whereas MCP-2/CCL8 was pseudogenized in every studied specimen of the Oryctolagus - Bunolagus lineage, this gene was intact in species of the Lepus - Sylvilagus lineage, and was, at least in Lepus, correctly transcribed. Conclusion The biological function of a gene was often

  1. DUMAND detector

    CERN Multimedia

    This object is one of the 256 other detectors of the DUMAND (Deep Underwater Muon And Neutrino Detection) experiment. The goal of the experiment was the construction of the first deep ocean high energy neutrino detector, to be placed at 4800 m depth in the Pacific Ocean off Keahole Point on the Big Island of Hawaii. A few years ago, a European conference with Cosmic experiments was organized at CERN as they were projects like DUMAND in Hawaii. Along with the conference, a temporary exhibition was organised as well. It was a collaboration of institutions from Germany, Japan, Switzerland and the U.S.A. CERN had borrowed equipment and objects from different institutes around the world, including this detector of the DUMAND experiment. Most of the equipment were sent back to the institutes, however this detector sphere was offered to a CERN member of the personnel.

  2. Detector applications

    International Nuclear Information System (INIS)

    Pehl, R.H.

    1977-10-01

    Semiconductor detectors are now applied to a very wide range of problems. The combination of relatively low cost, excellent energy resolution, and simultaneous broad energy-spectrum analysis is uniquely suited to many applications in both basic and applied physics. Alternative techniques, such as magnetic spectrometers for charged-particle spectroscopy, while offering better energy resolution, are bulky, expensive, and usually far more difficult to use. Furthermore, they do not directly provide the broad energy-spectrum measurements easily accomplished using semiconductor detectors. Scintillation detectors, which are approximately equivalent to semiconductor detectors in convenience and cost, exhibit 10 to 100 times worse energy resolution. However, their high efficiency and large potential size recommend their use in some measurements

  3. A position sensitive parallel plate avalanche counter

    International Nuclear Information System (INIS)

    Lombardi, M.; Tan Jilian; Potenza, R.; D'amico, V.

    1986-01-01

    A position sensitive parallel plate avalanche counter with a distributed constant delay-line-cathode (PSAC) is described. The strips formed on the printed board were served as the cathode and the delay line for readout of signals. The detector (PSAC) was operated in isobutane gas at the pressure range from 10 to 20 torr. The position resolution is better than 1 mm and the time resolution is about 350 ps, for 252 Cf fission-spectrum source

  4. Simulation of the effects of coated material SEY property on output electron energy distribution and gain of microchannel plates

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Lin [Key Laboratory of Ultra-fast Photoelectric Diagnostics Technology, Xi' an Institute of Optics and Precision Mechanics (XIOPM), Chinese Academy of Sciences (CAS), Xi' an 710119 (China); Graduate School of Chinese Academy of Sciences (CAS), Beijing 100049 (China); Xi' an Jiaotong University, Xi' an 710049 (China); Wang, Xingchao [North Night Vision Technology (NNVT) Co., Ltd., Nanjing 210110 (China); Tian, Jinshou, E-mail: tianjs@opt.ac.cn [Key Laboratory of Ultra-fast Photoelectric Diagnostics Technology, Xi' an Institute of Optics and Precision Mechanics (XIOPM), Chinese Academy of Sciences (CAS), Xi' an 710119 (China); Collaborative Innovation Center of Extreme Optics, Shanxi University, Taiyuan 030006 (China); Liu, Chunliang [Xi' an Jiaotong University, Xi' an 710049 (China); Liu, Hulin [Key Laboratory of Ultra-fast Photoelectric Diagnostics Technology, Xi' an Institute of Optics and Precision Mechanics (XIOPM), Chinese Academy of Sciences (CAS), Xi' an 710119 (China); Chen, Ping [Key Laboratory of Ultra-fast Photoelectric Diagnostics Technology, Xi' an Institute of Optics and Precision Mechanics (XIOPM), Chinese Academy of Sciences (CAS), Xi' an 710119 (China); Graduate School of Chinese Academy of Sciences (CAS), Beijing 100049 (China); Wei, Yonglin; Sai, Xiaofeng [Key Laboratory of Ultra-fast Photoelectric Diagnostics Technology, Xi' an Institute of Optics and Precision Mechanics (XIOPM), Chinese Academy of Sciences (CAS), Xi' an 710119 (China); Sun, Jianning; Si, Shuguang [North Night Vision Technology (NNVT) Co., Ltd., Nanjing 210110 (China); Wang, Xing; Lu, Yu [Key Laboratory of Ultra-fast Photoelectric Diagnostics Technology, Xi' an Institute of Optics and Precision Mechanics (XIOPM), Chinese Academy of Sciences (CAS), Xi' an 710119 (China); and others

    2016-12-21

    To obtain a high spatial resolution of a image intensifier based on microchannel plate (MCP), the long tail in the exit energy distribution of the output electrons (EDOE) is undesirable. The existing solution is increasing the penetration depth of the MCP output electrode, which will result in a serious gain reduction. Coating the MCP output electrode with efficient secondary electron yield (SEY) materials is supposed to be an effective approach to suppress the unfavorable tail component in the EDOE without negative effects on the gain. In our work, a three-dimensional MCP single channel model is developed in CST STUDIO SUITE to systematically investigate the dependences of the EDOE and the gain on the SEY property of the coated material, based on the Finite Integral Technique and Monte Carlo method. The results show that besides the high SEY of the coated material, the low incident energy corresponding to the peak SEY is another essential element affecting the electron yield in the final stage of multiplication and suppressing the output energy spread.

  5. Smoke detectors

    International Nuclear Information System (INIS)

    Bryant, J.; Howes, J.H.; Smout, D.W.S.

    1979-01-01

    A smoke detector is described which provides a smoke sensing detector and an indicating device and in which a radioactive substance is used in conjunction with two ionisation chambers. The system includes an outer electrode, a collector electrode and an inner electrode which is made of or supports the radioactive substance which, in this case, is 241 Am. The invention takes advantage of the fact that smoke particles can be allowed to enter freely the inner ionisation chamber. (U.K.)

  6. Radiation detector

    International Nuclear Information System (INIS)

    Gillies, W.

    1980-01-01

    The radiation detector for measuring e.g. a neutron flux consists of a central emitter, an insulating shell arranged around it, and a tube-shaped collector enclosing both. The emitter itself is composed of a great number of stranded, spiral wires of small diameter giving a defined flexibility to the detector. For emitter material Pt, Rh, V, Co, Ce, Os or Ta may be used. (DG) [de

  7. Split detector

    International Nuclear Information System (INIS)

    Cederstrand, C.N.; Chism, H.R.

    1982-01-01

    A gas analyzer is disclosed which provides a dual channel capability for the simultaneous determination of the presence and concentration of two gases in a stream of sample gas and which has a single infrared source, a single sample cell, two infrared bandpass filters, and two infrared detectors. A separator between the filters and detectors prevents interchange of radiation between the filters. The separator is positioned by fitting it in a slot

  8. Amorphous silicon based particle detectors

    OpenAIRE

    Wyrsch, N.; Franco, A.; Riesen, Y.; Despeisse, M.; Dunand, S.; Powolny, F.; Jarron, P.; Ballif, C.

    2012-01-01

    Radiation hard monolithic particle sensors can be fabricated by a vertical integration of amorphous silicon particle sensors on top of CMOS readout chip. Two types of such particle sensors are presented here using either thick diodes or microchannel plates. The first type based on amorphous silicon diodes exhibits high spatial resolution due to the short lateral carrier collection. Combination of an amorphous silicon thick diode with microstrip detector geometries permits to achieve micromete...

  9. Research on metal-plated cellulose nitrate flakes and their infrared / millimeter wave characteristics

    Science.gov (United States)

    Ye, Shu-qin; Zhu, Chen-guang; Wang, Li-hong; Ou'yang, De-hua; Pan, Gong-pei

    2016-10-01

    Copper-plated and silver-plated cellulose nitrate flakes, which were prepared by using chemical plating technology, were used to jam infrared detector and millimeter-wave radar. It was tested for the conductivity and infrared jamming performance of plating and also the RCS (Radar Cross Section) performance of millimeter-wave radar. Test results showed that the prepared metal-plated cellulose nitrate flakes have obvious conductivity, and infrared total radiation energy of silver plating and copper plating had approximately increased 32% and 21% respectively. Through determination, the millimeter-wave reflecting property and RCS of silver-plated cellulose nitrate flakes were higher than that of copper-plated cellulose nitrate flakes. Therefore, silver-plated cellulose nitrate flakes can be used as an effective infrared / millimeter wave composite jamming material.

  10. Postharvest quality of ‘Galaxy’ apples submitted to the treatment with 1-MCP and different cooling times between harvest and cold storage

    Directory of Open Access Journals (Sweden)

    Crizane Hackbarth

    Full Text Available ABSTRACT: In this research it was evaluated if the use of 1-methylcyclopropene (1-MCP, associated to different cooling times between the harvest and storage, replaces the pre-cooling in ‘Galaxy’ apples. Treatments were arranged in a factorial scheme, combining the following factors: application of 1-MCP (with or without and different times between harvest and cooling (24 hours, 96 hours, 144 hours and 192 hours in 2013; and 24 hours, 48 hours, 144 hours and 240 hours in 2014. After four months of cold storage (1.0±0.2°C/92±5% RH - Relative Humidity were evaluated: flesh firmness, texture, titratable acidity (TA, soluble solids (SS and skin color. Apples treated with 1-MCP showed greater flesh firmness, texture and SS, in both years, and more TA and lower incidence of mealy flesh compared to apples not treated with 1-MCP in 2013. The 1-MCP was effective in maintaining the fruit quality, even with the cooling delay of up to 240 hours. Cooling delay of 192 hours and 240 hours in ‘Galaxy’ apples not treated with 1-MCP should be avoided because it reduces the quality of fruits.

  11. Detector array and method

    International Nuclear Information System (INIS)

    Timothy, J.G.; Bybee, R.L.

    1978-01-01

    A detector array and method are described in which sets of electrode elements are provided. Each set consists of a number of linear extending parallel electrodes. The sets of electrode elements are disposed at an angle (preferably orthogonal) with respect to one another so that the individual elements intersect and overlap individual elements of the other sets. Electrical insulation is provided between the overlapping elements. The detector array is exposed to a source of charged particles which in accordance with one embodiment comprise electrons derived from a microchannel array plate exposed to photons. Amplifier and discriminator means are provided for each individual electrode element. Detection means are provided to sense pulses on individual electrode elements in the sets, with coincidence of pulses on individual intersecting electrode elements being indicative of charged particle impact at the intersection of the elements. Electronic readout means provide an indication of coincident events and the location where the charged particle or particles impacted. Display means are provided for generating appropriate displays representative of the intensity and locaton of charged particles impacting on the detector array

  12. Preparation of americium source for smoke detector

    International Nuclear Information System (INIS)

    Ramaswami, A.; Singh, R.J.; Manohar, S.B.

    1994-01-01

    This report describes the method developed for the preparation of 241 Am source for smoke detector. Americium was electrodeposited from iso-propyl alcohol medium on silver backing. Thin layer of gold (few hundred micro gram thick) was plated on the americium source to make it safe for handling. The thickness of plated gold was such that the alpha radiations from the 241 Am source could escape out of the gold layer and cause ionisation in the surrounding air. The performance of the prepared sources were checked in a smoke detector and was found to be satisfactory and comparable to the imported sources. (author). 1 refs., 2 figs., 1 tab

  13. The physics of Resistive Plate Chambers

    CERN Document Server

    Riegler, Werner

    2004-01-01

    Over the last 3 years we investigated theoretical aspects of Resistive Plate Chambers (RPC) in order to clarify some of the outstanding questions on space charge effects, high efficiency of small gap RPCs, charge spectra, signal shape and time resolution. In a series of reports we analyzed RPC performance including all detector aspects covering primary ionization, avalanche multiplication, space charge effects, signal induction in presence of resistive materials, crosstalk along detectors with long strips and front-end electronics. Using detector gas parameters entirely based on theoretical predictions and physical models for avalanche development and space charge effects we are able to reproduce measurements for 2 and 0.3 mm RPCs to very high accuracy without any additional assumptions. This fact gives a profound insight into the workings of RPCs and also underlines the striking difference in operation regime when compared to wire chambers. A summary of this work as well as recent results on three-dimensiona...

  14. Shaped detector

    International Nuclear Information System (INIS)

    Carlson, R.W.

    1981-01-01

    A radiation detector or detector array which has a non-constant spatial response, is disclosed individually and in combination with a tomographic scanner. The detector has a first dimension which is oriented parallel to the plane of the scan circle in the scanner. Along the first dimension, the detector is most responsive to radiation received along a centered segment of the dimension and less responsive to radiation received along edge segments. This non-constant spatial response can be achieved in a detector comprised of a scintillation crystal and a photoelectric transducer. The scintillation crystal in one embodiment is composed of three crystals arranged in layers, with the center crystal having the greatest light conversion efficiency. In another embodiment, the crystal is covered with a reflective substance around the center segment and a less reflective substance around the remainder. In another embodiment, an optical coupling which transmits light from adjacent the center segment with the greatest intensity couples the scintillation crystal and the photoelectric transducer. In yet another embodiment, the photoelectric transducer comprises three photodiodes, one receiving light produced adjacent the central segment and the other two receiving light produced adjacent the edge segments. The outputs of the three photodiodes are combined with a differential amplifier

  15. The Effect of Post-Resistance Exercise Amino Acids on Plasma MCP-1 and CCR2 Expression

    Directory of Open Access Journals (Sweden)

    Adam J. Wells

    2016-07-01

    Full Text Available The recruitment and infiltration of classical monocytes into damaged muscle is critical for optimal tissue remodeling. This study examined the effects of an amino acid supplement on classical monocyte recruitment following an acute bout of lower body resistance exercise. Ten resistance-trained men (24.7 ± 3.4 years; 90.1 ± 11.3 kg; 176.0 ± 4.9 cm ingested supplement (SUPP or placebo (PL immediately post-exercise in a randomized, cross-over design. Blood samples were obtained at baseline (BL, immediately (IP, 30-min (30P, 1-h (1H, 2-h (2H, and 5-h (5H post-exercise to assess plasma concentrations of monocyte chemoattractant protein 1 (MCP-1, myoglobin, cortisol and insulin concentrations; and expressions of C-C chemokine receptor-2 (CCR2, and macrophage-1 antigen (CD11b on classical monocytes. Magnitude-based inferences were used to provide inferences on the true effects of SUPP compared to PL. Changes in myoglobin, cortisol, and insulin concentrations were similar between treatments. Compared to PL, plasma MCP-1 was “very likely greater” (98.1% likelihood effect in SUPP at 2H. CCR2 expression was “likely greater” at IP (84.9% likelihood effect, “likely greater” at 1H (87.7% likelihood effect, “very likely greater” at 2H (97.0% likelihood effect, and “likely greater” at 5H (90.1% likelihood effect in SUPP, compared to PL. Ingestion of SUPP did not influence CD11b expression. Ingestion of an amino acid supplement immediately post-exercise appears to help maintain plasma MCP-1 concentrations and augment CCR2 expression in resistance trained men.

  16. Create Your Plate

    Medline Plus

    Full Text Available ... Type 2 Diabetes Know Your Rights Employment Discrimination Health Care Professionals Law ... Your Plate Gluten Free Diets Meal Planning for Vegetarian Diets Cook with Heart- ...

  17. Create Your Plate

    Medline Plus

    Full Text Available ... Plate Gluten Free Diets Meal Planning for Vegetarian Diets Cook with Heart-Healthy Foods Holiday ... Carbohydrates Types of Carbohydrates Carbohydrate Counting Make Your Carbs ...

  18. Results obtained with the passive radiation detectors in the ICCHIBAN-4 experiment

    International Nuclear Information System (INIS)

    Bilski, P.; Horwacik, T.

    2005-05-01

    In frame of the InterComparison of Cosmic rays with Heavy Ions Beams at NIRS (ICCHIBAN) organized at the HIMAC accelerator in Chiba several types of the thermoluminescent detectors (TLD), as well as CR-39 track detectors, were exposed. Four different types of TLDs were used: MTS-7 ( 7 LiF:Mg,Ti), MTS-6 ( 6 LiF:Mg,Ti), MCP-7 ( 7 LiF:Mg,Cu,P) and MTT-7 ( 7 LiF:Mg,Ti with changed activator composition. All TLDs were manufactured at the Institute of Nuclear Physics (INP) in Cracow. The detectors were irradiated with various doses of He, C, Ne and Fe ions. Part of exposures were done in unknown conditions, to test measuring capabilities of the detectors. For analyses of these results, the method of obtaining information on ionisation density of an unknown radiation field, which is based on ratios of responses of different LiF detectors, was successfully used. (author)

  19. arXiv On the localization properties of an RPWELL gas-avalanche detector

    CERN Document Server

    Moleri, Luca; Coimbra, Artur E. C.; Breskin, Amos; Bressler, Shikma

    2017-10-23

    A study of the localization properties of a single-element Resistive Plate WELL (RPWELL) detector is presented. The detector comprises of a single-sided THick Gaseous Electron Multiplier (THGEM) coupled to a segmented readout anode through a doped silicate-glass plate of 10(10) Ω⋅cm bulk resistivity. Operated in ambient \

  20. BES detector

    International Nuclear Information System (INIS)

    Bai, J.Z.; Bian, Q.; Chen, G.M.; Chen, L.J.; Chen, S.N.; Chen, Y.Q.; Chen, Z.Q.; Chi, Y.K.; Cui, H.C.; Cui, X.Z.; Deng, S.S.; Deng, Y.W.; Ding, H.L.; Dong, B.Z.; Dong, X.S.; Du, X.; Du, Z.Z.; Feng, C.; Feng, Z.; Fu, Z.S.; Gao, C.S.; Gao, M.L.; Gao, S.Q.; Gao, W.X.; Gao, Y.N.; Gu, S.D.; Gu, W.X.; Guan, Y.Z.; Guo, H.F.; Guo, Y.N.; Guo, Y.Y.; Han, S.W.; Han, Y.; Hao, W.; He, J.; He, K.R.; He, M.J.; Hou, X.J.; Hu, G.Y.; Hu, J.S.; Hu, J.W.; Huang, D.Q.; Huang, Y.Z.; Jia, Q.P.; Jiang, C.H.; Ju, Q.; Lai, Y.F.; Lang, P.F.; Li, D.S.; Li, F.; Li, H.; Li Jia; Li, J.T.; Li Jin; Li, L.L.; Li, P.Q.; Li, Q.M.; Li, R.B.; Li, S.Q.; Li, W.; Li, W.G.; Li, Z.X.; Liang, G.N.; Lin, F.C.; Lin, S.Z.; Lin, W.; Liu, Q.; Liu, R.G.; Liu, W.; Liu, X.; Liu, Z.A.; Liu, Z.Y.; Lu, C.G.; Lu, W.D.; Lu, Z.Y.; Lu, J.G.; Ma, D.H.; Ma, E.C.; Ma, J.M.; Mao, H.S.; Mao, Z.P.; Meng, X.C.; Ni, H.L.; Nie, J.; Nie, Z.D.; Niu, W.P.; Pan, L.J.; Qi, N.D.; Qian, J.J.; Qu, Y.H.; Que, Y.K.; Rong, G.; Ruan, T.Z.; Shao, Y.Y.; Shen, B.W.; Shen, D.L.; Shen, J.; Sheng, H.Y.; Sheng, J.P.; Shi, H.Z.; Song, X.F.; Sun, H.S.; Tang, F.K.; Tang, S.Q.; Tian, W.H.; Wang, F.; Wang, G.Y.; Wang, J.G.; Wang, J.Y.; Wang, L.S.; Wang, L.Z.; Wang, M.; Wang, P.; Wang, P.L.; Wang, S.M.; Wang, S.Q.; Wang, T.J.; Wang, X.W.; Wang, Y.Y.; Wang, Z.H.; Wang, Z.J.; Wei, C.L.; Wei, Z.Z.; Wu, J.W.; Wu, S.H.; Wu, S.Q.; Wu, W.M.; Wu, X.D.; Wu, Z.D.; Xi, D.M.; Xia, X.M.; Xiao, J.; Xie, P.P.; Xie, X.X.; Xu, J.G.; Xu, R.S.; Xu, Z.Q.; Xuan, B.C.; Xue, S.T.; Yan, J.; Yan, S.P.; Yan, W.G.; Yang, C.Z.; Yang, C.M.; Yang, C.Y.; Yang, X.F.; Yang, X.R.; Ye, M.H.; Yu, C.H.; Yu, C.S.; Yu, Z.Q.; Zhang, B.Y.; Zhang, C.D.; Zhang, C.C.; Zhang, C.Y.; Zhang, D.H.; Zhang, G.; Zhang, H.Y.; Zhang, H.L.; Zhang, J.W.; Zhang, L.S.; Zhang, S.Q.; Zhang, Y.P.; Zhang, Y.; Zhang, Y.M.; Zhao, D.X.; Zhao, J.W.; Zhao, M.; Zhao, P.D.; Zhao, P.P.; Zhao, W.R.; Zhao, Z.G.; Zhao, Z.Q.; Zheng, J.P.; Zheng, L.S.; Zheng, M.; Zheng, W.S.; Zheng, Z.P.; Zhong, G.P.; Zhou, G.P.; Zhou, H.S.; Zhou, J.; Zhou Li; Zhou Lin; Zhou, M.; Zhou, Y.S.; Zhou, Y.H.; Zhu, G.S.; Zhu, Q.M.; Zhu, S.G.; Zhu, Y.C.; Zhu, Y.S.; Zhuang, B.A.

    1994-01-01

    The Beijing Spectrometer (BES) is a general purpose solenoidal detector at the Beijing Electron Positron Collider (BEPC). It is designed to study exclusive final states in e + e - annihilations at the center of mass energy from 3.0 to 5.6 GeV. This requires large solid angle coverage combined with good charged particle momentum resolution, good particle identification and high photon detection efficiency at low energies. In this paper we describe the construction and the performance of BES detector. (orig.)

  1. Analogue saturation limit of single and double 10 mm microchannel plate photomultiplier tubes

    Energy Technology Data Exchange (ETDEWEB)

    Milnes, J. S., E-mail: james.milnes@photek.co.uk; Conneely, T. M. [Photek Ltd., 26 Castleham Road, St Leonards on Sea, East Sussex TN38 9NS (United Kingdom); Horsfield, C. J. [AWE Aldermaston, Reading, Berkshire RG7 4PR (United Kingdom)

    2016-11-15

    Photek are a well-established supplier of microchannel plate (MCP) photomultiplier tubes (PMTs) to the inertial confinement fusion community. The analogue signals produced at the major inertial confinement fusion facilities cover many orders of magnitude, therefore understanding the upper saturation limit of MCP-PMTs to large low rate signals takes on a high importance. Here we present a study of a single and a double MCP-PMT with 10 mm diameter active area. The saturation was studied for a range of optical pulse widths from 4 ns to 100 ns and at a range of electron gain values: 10{sup 3} to 10{sup 4} for the single and 10{sup 4} to 10{sup 6} for the double. We have shown that the saturation level of ∼1.2 nC depends only on the integrated charge of the pulse and is independent of pulse width and gain over this range, but that the level of charge available in deep saturation is proportional to the operating gain.

  2. Increased Eotaxin and MCP-1 Levels in Serum from Individuals with Periodontitis and in Human Gingival Fibroblasts Exposed to Pro-Inflammatory Cytokines

    Science.gov (United States)

    Sulniute, Rima; Palmqvist, Py; Majster, Mirjam; Holm, Cecilia Koskinen; Zwicker, Stephanie; Clark, Reuben; Önell, Sebastian; Johansson, Ingegerd; Lerner, Ulf H.; Lundberg, Pernilla

    2015-01-01

    Periodontitis is a chronic inflammatory disease of tooth supporting tissues resulting in periodontal tissue destruction, which may ultimately lead to tooth loss. The disease is characterized by continuous leukocyte infiltration, likely mediated by local chemokine production but the pathogenic mechanisms are not fully elucidated. There are no reliable serologic biomarkers for the diagnosis of periodontitis, which is today based solely on the degree of local tissue destruction, and there is no available biological treatment tool. Prompted by the increasing interest in periodontitis and systemic inflammatory mediators we mapped serum cytokine and chemokine levels from periodontitis subjects and healthy controls. We used multivariate partial least squares (PLS) modeling and identified monocyte chemoattractant protein-1 (MCP-1) and eotaxin as clearly associated with periodontitis along with C-reactive protein (CRP), years of smoking and age, whereas the number of remaining teeth was associated with being healthy. Moreover, body mass index correlated significantly with serum MCP-1 and CRP, but not with eotaxin. We detected higher MCP-1 protein levels in inflamed gingival connective tissue compared to healthy but the eotaxin levels were undetectable. Primary human gingival fibroblasts displayed strongly increased expression of MCP-1 and eotaxin mRNA and protein when challenged with tumor necrosis factor-α (TNF-α and interleukin-1β (IL-1β), key mediators of periodontal inflammation. We also demonstrated that the upregulated chemokine expression was dependent on the NF-κΒ pathway. In summary, we identify higher levels of CRP, eotaxin and MCP-1 in serum of periodontitis patients. This, together with our finding that both CRP and MCP-1 correlates with BMI points towards an increased systemic inflammatory load in patients with periodontitis and high BMI. Targeting eotaxin and MCP-1 in periodontitis may result in reduced leukocyte infiltration and inflammation in

  3. MCP-1/CCR-2-double-deficiency severely impairs the migration of hematogenous inflammatory cells following transient cerebral ischemia in mice.

    Science.gov (United States)

    Schuette-Nuetgen, Katharina; Strecker, Jan-Kolja; Minnerup, Jens; Ringelstein, E Bernd; Schilling, Matthias

    2012-02-01

    Monocyte chemoattractant protein-1 (MCP-1) and its receptor CCR-2 are known to play a major role in inflammatory responses after cerebral ischemia. Mice deficient in either MCP-1 or CCR-2 have been reported to develop smaller infarct sizes and show decreased numbers of infiltrating inflammatory cells. In the present study we used green fluorescent protein (GFP) transgenic mice to investigate the effect of MCP-1/CCR-2-double deficiency on the recruitment of inflammatory cells in a model of both, mild and severe cerebral ischemia. We show that MCP-1/CCR-2-double deficiency virtually entirely abrogates the recruitment of hematogenous macrophages and significantly reduces neutrophil migration to the ischemic brain 4 and 7 days following focal cerebral ischemia. This argues for a predominant role of the MCP-1/CCR-2 axis in chemotaxis of monocytes despite a wide redundancy in the chemokine-receptor-system. Chemokine analysis revealed that even candidates known to be involved in monocyte and neutrophil recruitment like MIP-1α, CXCL-1, C5a, G-CSF and GM-CSF showed a reduced and delayed or even a lack of relevant compensatory response in MCP-1(-/-)/CCR-2(-/-)-mice. Solely, chemokine receptor 5 (CCR-5) increased early in both, but rose above wildtype levels at day 7 in MCP-1(-/-)/CCR-2(-/-)-animals, which might explain the higher number of activated microglial cells compared to control mice. Our study was, however, not powered to investigate infarct volumes. Further studies are needed to clarify whether these mechanisms of inflammatory cell recruitment might be essential for early infarct development and final infarct size and to evaluate potential therapeutic implications. Copyright © 2011 Elsevier Inc. All rights reserved.

  4. Joint effect of MCP-1 genotype GG and MMP-1 genotype 2G/2G increases the likelihood of developing pulmonary tuberculosis in BCG-vaccinated individuals.

    Directory of Open Access Journals (Sweden)

    Malathesha Ganachari

    2010-01-01

    Full Text Available We previously reported that the -2518 MCP-1 genotype GG increases the likelihood of developing tuberculosis (TB in non-BCG-vaccinated Mexicans and Koreans. Here, we tested the hypothesis that this genotype, alone or together with the -1607 MMP-1 functional polymorphism, increases the likelihood of developing TB in BCG-vaccinated individuals. We conducted population-based case-control studies of BCG-vaccinated individuals in Mexico and Peru that included 193 TB cases and 243 healthy tuberculin-positive controls from Mexico and 701 TB cases and 796 controls from Peru. We also performed immunohistochemistry (IHC analysis of lymph nodes from carriers of relevant two-locus genotypes and in vitro studies to determine how these variants may operate to increase the risk of developing active disease. We report that a joint effect between the -2518 MCP-1 genotype GG and the -1607 MMP-1 genotype 2G/2G consistently increases the odds of developing TB 3.59-fold in Mexicans and 3.9-fold in Peruvians. IHC analysis of lymph nodes indicated that carriers of the two-locus genotype MCP-1 GG MMP-1 2G/2G express the highest levels of both MCP-1 and MMP-1. Carriers of these susceptibility genotypes might be at increased risk of developing TB because they produce high levels of MCP-1, which enhances the induction of MMP-1 production by M. tuberculosis-sonicate antigens to higher levels than in carriers of the other two-locus MCP-1 MMP-1 genotypes studied. This notion was supported by in vitro experiments and luciferase based promoter activity assay. MMP-1 may destabilize granuloma formation and promote tissue damage and disease progression early in the infection. Our findings may foster the development of new and personalized therapeutic approaches targeting MCP-1 and/or MMP-1.

  5. Joint effect of MCP-1 genotype GG and MMP-1 genotype 2G/2G increases the likelihood of developing pulmonary tuberculosis in BCG-vaccinated individuals.

    Science.gov (United States)

    Ganachari, Malathesha; Ruiz-Morales, Jorge A; Gomez de la Torre Pretell, Juan C; Dinh, Jeffrey; Granados, Julio; Flores-Villanueva, Pedro O

    2010-01-25

    We previously reported that the -2518 MCP-1 genotype GG increases the likelihood of developing tuberculosis (TB) in non-BCG-vaccinated Mexicans and Koreans. Here, we tested the hypothesis that this genotype, alone or together with the -1607 MMP-1 functional polymorphism, increases the likelihood of developing TB in BCG-vaccinated individuals. We conducted population-based case-control studies of BCG-vaccinated individuals in Mexico and Peru that included 193 TB cases and 243 healthy tuberculin-positive controls from Mexico and 701 TB cases and 796 controls from Peru. We also performed immunohistochemistry (IHC) analysis of lymph nodes from carriers of relevant two-locus genotypes and in vitro studies to determine how these variants may operate to increase the risk of developing active disease. We report that a joint effect between the -2518 MCP-1 genotype GG and the -1607 MMP-1 genotype 2G/2G consistently increases the odds of developing TB 3.59-fold in Mexicans and 3.9-fold in Peruvians. IHC analysis of lymph nodes indicated that carriers of the two-locus genotype MCP-1 GG MMP-1 2G/2G express the highest levels of both MCP-1 and MMP-1. Carriers of these susceptibility genotypes might be at increased risk of developing TB because they produce high levels of MCP-1, which enhances the induction of MMP-1 production by M. tuberculosis-sonicate antigens to higher levels than in carriers of the other two-locus MCP-1 MMP-1 genotypes studied. This notion was supported by in vitro experiments and luciferase based promoter activity assay. MMP-1 may destabilize granuloma formation and promote tissue damage and disease progression early in the infection. Our findings may foster the development of new and personalized therapeutic approaches targeting MCP-1 and/or MMP-1.

  6. Aspergillus antigen induces robust Th2 cytokine production, inflammation, airway hyperreactivity and fibrosis in the absence of MCP-1 or CCR2

    Directory of Open Access Journals (Sweden)

    Charo Israel F

    2004-09-01

    Full Text Available Abstract Background Asthma is characterized by type 2 T-helper cell (Th2 inflammation, goblet cell hyperplasia, airway hyperreactivity, and airway fibrosis. Monocyte chemoattractant protein-1 (MCP-1 or CCL2 and its receptor, CCR2, have been shown to play important roles in the development of Th2 inflammation. CCR2-deficient mice have been found to have altered inflammatory and physiologic responses in some models of experimental allergic asthma, but the role of CCR2 in contributing to inflammation and airway hyperreactivity appears to vary considerably between models. Furthermore, MCP-1-deficient mice have not previously been studied in models of experimental allergic asthma. Methods To test whether MCP-1 and CCR2 are each required for the development of experimental allergic asthma, we applied an Aspergillus antigen-induced model of Th2 cytokine-driven allergic asthma associated with airway fibrosis to mice deficient in either MCP-1 or CCR2. Previous studies with live Aspergillus conidia instilled into the lung revealed that MCP-1 and CCR2 play a role in anti-fungal responses; in contrast, we used a non-viable Aspergillus antigen preparation known to induce a robust eosinophilic inflammatory response. Results We found that wild-type C57BL/6 mice developed eosinophilic airway inflammation, goblet cell hyperplasia, airway hyperreactivity, elevations in serum IgE, and airway fibrosis in response to airway challenge with Aspergillus antigen. Surprisingly, mice deficient in either MCP-1 or CCR2 had responses to Aspergillus antigen similar to those seen in wild-type mice, including production of Th2 cytokines. Conclusion We conclude that robust Th2-mediated lung pathology can occur even in the complete absence of MCP-1 or CCR2.

  7. The Successful Operation of Hole-type Gaseous Detectors at Cryogenic Temperatures

    CERN Document Server

    Pereiale, L.; Iacobaeus, C.; Francke, T.; Lund-Jensen, B.; Pavlopoulos, P.; Picchi, P.; Pietropaolo, F.; Tokanai, F.

    2004-01-01

    We have demonstrated that hole-type gaseous detectors, GEMs and capillary plates, can operate up to 77 K. For example, a single capillary plate can operate at gains of above 10E3 in the entire temperature interval between 300 until 77 K. The same capillary plate combined with CsI photocathodes could operate perfectly well at gains (depending on gas mixtures) of 100-1000. Obtained results may open new fields of applications for capillary plates as detectors of UV light and charge particles at cryogenic temperatures: noble liquid TPCs, WIMP detectors or LXe scintillating calorimeters and cryogenic PETs.

  8. Neutron detector using sol-gel absorber

    Science.gov (United States)

    Hiller, John M.; Wallace, Steven A.; Dai, Sheng

    1999-01-01

    An neutron detector composed of fissionable material having ions of lithium, uranium, thorium, plutonium, or neptunium, contained within a glass film fabricated using a sol-gel method combined with a particle detector is disclosed. When the glass film is bombarded with neutrons, the fissionable material emits fission particles and electrons. Prompt emitting activated elements yielding a high energy electron contained within a sol-gel glass film in combination with a particle detector is also disclosed. The emissions resulting from neutron bombardment can then be detected using standard UV and particle detection methods well known in the art, such as microchannel plates, channeltrons, and silicon avalanche photodiodes.

  9. EFECTO DEL EMPAQUE Y DEL 1-MCP SOBRE CARACTERÍSTICAS FÍSICAS, QUÍMICAS Y FISIOLÓGICAS DE PITAHAYA AMARILLA EFEITO DA EMBALAGEM E DO 1-MCP SOB AS PROPRIEDADES QUÍMICAS, FÍSICAS E FISIOLÓGICAS DA PITAHAYA AMARELA EFFECT OF PACKAGING AND 1-MCP ON PHYSICAL, CHEMICAL AND PHYSIOLOGICAL CHARACTERISTICS OF PITAHAYA YELLOW

    Directory of Open Access Journals (Sweden)

    LILIANA SERNA C

    2011-12-01

    Full Text Available En pitahaya amarilla entera con grado de madurez 3, se evaluó el efecto del empaque (canastillas plásticas y cajas de cartón tipo exportación y la aplicación de soluciones acuosas de 1-Metilciclopropeno (200 y 400 µgL-1, sobre la pérdida de peso, firmeza, color, sólidos solubles, acidez titulable, tasa respiratoria y tiempo de vida comercial. Se encontró que en los dos empaques, la aplicación de soluciones acuosas de 200 y 400 µgL-1 de 1-Metilciclopropeno (1-MCP disminuyó los cambios en acidez, tasa respiratoria y color, sin embargo, aumentó la pérdida de peso durante el almacenamiento. El tipo de empaque afectó significativamente la pérdida de peso, los sólidos solubles y el color. La aplicación de 200 µgL-1 de 1-MCP generó menor variación en la luminosidad y en la coloración verde-amarilla en la fruta. Concentraciones de 200 y 400 µgL-1 de 1-MCP y el empaque en canastillas plásticas para mercado local permitieron prolongar el tiempo de vida comercial de la pitahaya amarilla 3 días. Los resultados de este estudio confirman además que la pitahaya amarilla es una fruta climatérica.Na pitahaya amarela inteira com grau tres de madures, foi avallado os efeitos da embalagem (cestos de plástico e caixas de papelão tipo exportação e a aplicação de soluções aquosas de 1-metilciclopropeno (200 e 400 µgL-1 sobre a perda de peso, firmeza, cor, teor de sólidos solúveis totais, acidez, taxa de respiração e tempo de vida comercial. Foi observado que nas duas embalagens, a aplicação de soluções aquosas de 200 e 400 µgL-1 de 1-Metilciclopropeno (1-MCP reduziu as variações na acidez, taxa de respiração e cor, no entanto, aumentou a perda de peso durante o armazenamento. 0 tipo da embalagem afetou significativamente a perda de peso, o teor de sólidos solúveis totais, e acor. A aplicação de 200 µgL-1 de 1-MCP gerou menor variação na luminosidade e na cor verde-amarela no fruto. Concentrações de 200 e 400

  10. Vertex detectors

    International Nuclear Information System (INIS)

    Lueth, V.

    1992-07-01

    The purpose of a vertex detector is to measure position and angles of charged particle tracks to sufficient precision so as to be able to separate tracks originating from decay vertices from those produced at the interaction vertex. Such measurements are interesting because they permit the detection of weakly decaying particles with lifetimes down to 10 -13 s, among them the τ lepton and charm and beauty hadrons. These two lectures are intended to introduce the reader to the different techniques for the detection of secondary vertices that have been developed over the past decades. The first lecture includes a brief introduction to the methods used to detect secondary vertices and to estimate particle lifetimes. It describes the traditional technologies, based on photographic recording in emulsions and on film of bubble chambers, and introduces fast electronic registration of signals derived from scintillating fibers, drift chambers and gaseous micro-strip chambers. The second lecture is devoted to solid state detectors. It begins with a brief introduction into semiconductor devices, and then describes the application of large arrays of strip and pixel diodes for charged particle tracking. These lectures can only serve as an introduction the topic of vertex detectors. Time and space do not allow for an in-depth coverage of many of the interesting aspects of vertex detector design and operation

  11. Smoke detectors

    International Nuclear Information System (INIS)

    Macdonald, E.

    1976-01-01

    A smoke detector is described consisting of a ventilated ionisation chamber having a number of electrodes and containing a radioactive source in the form of a foil supported on the surface of the electrodes. This electrode consists of a plastic material treated with graphite to render it electrically conductive. (U.K.)

  12. Semiconductor Detectors

    International Nuclear Information System (INIS)

    Cortina, E.

    2007-01-01

    Particle detectors based on semiconductor materials are among the few devices used for particle detection that are available to the public at large. In fact we are surrounded by them in our daily lives: they are used in photoelectric cells for opening doors, in digital photographic and video camera, and in bar code readers at supermarket cash registers. (Author)

  13. Capillary detectors

    International Nuclear Information System (INIS)

    Konijn, J.; Winter, K.; Vilain, P.; Wilquet, G.; Fabre, J.P.; Kozarenko, E.; Kreslo, I.; Goldberg, J.; Hoepfner, K.; Bay, A.; Currat, C.; Koppenburg, P.; Frekers, D.; Wolff, T.; Buontempo, S.; Ereditato, A.; Frenkel, A.; Liberti, B.; Martellotti, G.; Penso, G.; Ekimov, A.; Golovkin, S.; Govorun, V.; Medvedkov, A.; Vasil'chenko, V.

    1998-01-01

    The option for a microvertex detector using glass capillary arrays filled with liquid scintillator is presented. The status of capillary layers development and possible read-out techniques for high rate environment are reported. (Copyright (c) 1998 Elsevier Science B.V., Amsterdam. All rights reserved.)

  14. Create Your Plate

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  16. Create Your Plate

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  17. Create Your Plate

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    Full Text Available ... ready, you can try new foods within each food category. Try these seven steps to get started: Using your dinner plate, put a line down the middle of the plate. Then on one side, cut it ... and starchy foods. See this list of grains and starchy foods . ...

  18. Towards stacked zone plates

    International Nuclear Information System (INIS)

    Werner, S; Rehbein, S; Guttman, P; Heim, S; Schneider, G

    2009-01-01

    Fresnel zone plates are the key optical elements for soft and hard x-ray microscopy. For short exposure times and minimum radiation load of the specimen the diffraction efficiency of the zone plate objectives has to be maximized. As the efficiency strongly depends on the height of the diffracting zone structures the achievable aspect ratio of the nanostructures determines these limits. To reach aspect ratios ≥ 20:1 for high efficient optics we propose to superimpose zone plates on top of each other. With this multiplication approach the final aspect ratio is only limited by the number of stacked zone plate layers. For the stack process several nanostructuring process steps have to be developed and/or improved. Our results show for the first time two layers of zone plates stacked on top of each other.

  19. Prokaryotic expression and in vitro functional analysis of IL-1β and MCP-1 from guinea pig.

    Science.gov (United States)

    Dirisala, Vijaya R; Jeevan, Amminikutty; Ly, Lan H; McMurray, David N

    2013-06-01

    The Guinea pig (Cavia porcellus) is an excellent animal model for studying human tuberculosis (TB) and also for a number of other infectious and non-infectious diseases. One of the major roadblocks in effective utilization of this animal model is the lack of readily available immunological reagents. In order to address this issue, guinea pig interleukin 1 beta (IL-1β) and monocyte chemoattractant protein-1 (MCP-1) were efficiently cloned and expressed in a prokaryotic expression vector, and the expressed proteins in soluble form from both the genes were confirmed by N-terminal sequencing. The biological activity of recombinant guinea pig IL-1β was demonstrated by its ability to drive proliferation in thymocytes, and the recombinant guinea pig MCP-1 exhibited chemotactic activity for guinea pig resident peritoneal macrophages. These biologically active recombinant guinea pig proteins will facilitate an in-depth understanding of the role they play in the immune responses of the guinea pig to TB and other diseases.

  20. PEG-albumin plasma expansion increases expression of MCP-1 evidencing increased circulatory wall shear stress: an experimental study.

    Directory of Open Access Journals (Sweden)

    C Makena Hightower

    Full Text Available Treatment of blood loss with plasma expanders lowers blood viscosity, increasing cardiac output. However, increased flow velocity by conventional plasma expanders does not compensate for decreased viscosity in maintaining vessel wall shear stress (WSS, decreasing endothelial nitric oxide (NO production. A new type of plasma expander using polyethylene glycol conjugate albumin (PEG-Alb causes supra-perfusion when used in extreme hemodilution and is effective in treating hemorrhagic shock, although it is minimally viscogenic. An acute 40% hemodilution/exchange-transfusion protocol was used to compare 4% PEG-Alb to Ringer's lactate, Dextran 70 kDa and 6% Hetastarch (670 kDa in unanesthetized CD-1 mice. Serum cytokine analysis showed that PEG-Alb elevates monocyte chemotactic protein-1 (MCP-1, a member of a small inducible gene family, as well as expression of MIP-1α, and MIP-2. MCP-1 is specific to increased WSS. Given the direct link between increased WSS and production of NO, the beneficial resuscitation effects due to PEG-Alb plasma expansion appear to be due to increased WSS through increased perfusion and blood flow rather than blood viscosity.

  1. Muscle glycogen depletion following 75-km of cycling is not linked to increased muscle IL-6, IL-8, and MCP-1 mRNA expression and protein content

    Directory of Open Access Journals (Sweden)

    David Christopher Nieman

    2016-09-01

    Full Text Available The cytokine response to heavy exertion varies widely for unknown reasons, and this study evaluated the relative importance of glycogen depletion, muscle damage, and stress hormone changes on blood and muscle cytokine measures. Cyclists (N=20 participated in a 75-km cycling time trial (168±26.0 min, with blood and vastus lateralis muscle samples collected before and after. Muscle glycogen decreased 77.2±17.4%, muscle IL-6, IL-8, and MCP-1 mRNA increased 18.5±2.8-, 45.3±7.8-, and 8.25±1.75-fold, and muscle IL-6, IL-8, and MCP-1 protein increased 70.5±14.1%, 347±68.1%, and 148±21.3%, respectively (all, P<0.001. Serum myoglobin and cortisol increased 32.1±3.3 to 242±48.3 mg/mL, and 295±27.6 to 784±63.5 nmol/L, respectively (both P<0.001. Plasma IL-6, IL-8, and MCP-1 increased 0.42±0.07 to 18.5±3.8, 4.07±0.37 to 17.0±1.8, and 96.5±3.7 to 240±21.6 pg/mL, respectively (all P<0.001. Increases in muscle IL-6, IL-8, and MCP-1 mRNA were unrelated to any of the outcome measures. Muscle glycogen depletion was related to change in plasma IL-6 (r=0.462, P=0.040, with change in myoglobin related to plasma IL-8 (r=0.582, P=0.007 and plasma MCP-1 (r=0.457, P=0.043, and muscle MCP-1 protein (r=0.588, P=0.017; cortisol was related to plasma IL-8 (r=0.613, P=0.004, muscle IL-8 protein (r=0.681, P=0.004, and plasma MCP-1 (r=0.442, P=0.050. In summary, this study showed that muscle IL-6, IL-8, and MCP-1 mRNA expression after 75-km cycling was unrelated to glycogen depletion and muscle damage, with change in muscle glycogen related to plasma IL-6, and changes in serum myoglobin and cortisol related to the chemotactic cytokines IL-8 and MCP-1.

  2. Correlation of serum MCP-1 and VE-cadherin levels with neural function and carotid atherosclerosis in patients with acute cerebral infarction

    Directory of Open Access Journals (Sweden)

    Yan-Bing Xi

    2017-05-01

    Full Text Available Objective: To study the correlation of serum monocyte chemoattractant protein-1 (MCP-1 and vascular endothelial cadherin (VE-cadherin levels with neural function and carotid atherosclerosis in patients with acute cerebral infarction. Methods: A total of 78 patients who were diagnosed with acute cerebral infarction in our hospital between May 2013 and August 2016 were selected as pathological group, and 80 healthy volunteers who received physical examination in our hospital during the same period were selected as control group. Serum was collected to determine the levels of MCP-1, VE-cadherin, nerve injury molecules, inflammatory mediators, proteases and their hydrolysate. Results: Serum MCP-1, VE-cadherin, NGB, NSE, S100β, HMGB-1, sCD40L, YKL-40, visfatin, CatK, MMP9 and ICTP levels of pathological group were significantly higher than those of control group; serum MCP-1 and VE-cadherin levels of pathological group were positively correlated with NGB, NSE, S100β, HMGB-1, sCD40L, YKL-40, visfatin, CatK, MMP9 and ICTP levels. Conclusion: Serum MCP-1 and VE-cadherin levels abnormally increase in patients with acute cerebral infarction, and are closely related to the nerve injury and atherosclerosis process.

  3. A projective geometry lead fiber scintillator detector

    International Nuclear Information System (INIS)

    Paar, H.; Thomas, D.; Sivertz, M.; Ong, B.; Acosta, D.; Taylor, T.; Shreiner, B.

    1990-01-01

    The Superconducting Super Collider (SSC), presently under construction near Dallas, Texas requires highly sophisticated particle detectors. The energy and particle flux at the SSC are more than an order of magnitude higher than the highest machine located at the Fermi National Accelerator near Chicago. An important element of particle detectors for the SSC is the calorimeter. It measures a particle's energy by sampling its energy deposit in heavy material, such as (depleted) uranium or lead. The sampling medium must be interspersed with heavy absorber material. In the case of scintillating plastic, two methods are under consideration: plates and fibers. In the case of plates, a sandwich of scintillator plates and uranium plates is constructed. In the use of fibers (still in the prototype stage), 1 mm. diameter cylindrical scintillating fibers are inserted into grooves that are machined into lead layers. The layers are stacked and epoxied together to form the required geometrical shape of the detector. Lead and scintillating plastic sampling can meet the physics requirements of the detector. This has been shown in an R ampersand D program which is underway at the University of California at San Diego (UCSD), High Energy Physics Group. This R ampersand D is funded by the Department of Energy, High Energy Physics and SSC Divisions

  4. The simulation of resistive plate chambers in avalanche mode: charge spectra and efficiency

    Energy Technology Data Exchange (ETDEWEB)

    Abbrescia, M. E-mail: Marcello.abbrescia@ba.infn.it; Colaleo, A.; Iaselli, G.; Loddo, F.; Maggi, M.; Marangelli, B.; Natali, S.; Nuzzo, S.; Pugliese, G.; Ranieri, A.; Romano, F.; Altieri, S.; Bruno, G.; Gianini, G.; Ratti, S.P.; Viola, L.; Vitulo, P

    1999-07-21

    A model to simulate the avalanche formation process and the induced signal in a Resistive Plate Chamber is presented. A first investigation of the effects of various parameters on the performance of this detector is reported. (author)

  5. High Frequency Design Considerations for the Large Detector Number and Small Form Factor Dual Electron Spectrometer of the Fast Plasma Investigation on NASA's Magnetospheric Multiscale Mission

    Science.gov (United States)

    Kujawski, Joseph T.; Gliese, Ulrik B.; Cao, N. T.; Zeuch, M. A.; White, D.; Chornay, D. J; Lobell, J. V.; Avanov, L. A.; Barrie, A. C.; Mariano, A. J.; hide

    2015-01-01

    Each half of the Dual Electron Spectrometer (DES) of the Fast Plasma Investigation (FPI) on NASA's Magnetospheric MultiScale (MMS) mission utilizes a microchannel plate Chevron stack feeding 16 separate detection channels each with a dedicated anode and amplifier/discriminator chip. The desire to detect events on a single channel with a temporal spacing of 100 ns and a fixed dead-time drove our decision to use an amplifier/discriminator with a very fast (GHz class) front end. Since the inherent frequency response of each pulse in the output of the DES microchannel plate system also has frequency components above a GHz, this produced a number of design constraints not normally expected in electronic systems operating at peak speeds of 10 MHz. Additional constraints are imposed by the geometry of the instrument requiring all 16 channels along with each anode and amplifier/discriminator to be packaged in a relatively small space. We developed an electrical model for board level interactions between the detector channels to allow us to design a board topology which gave us the best detection sensitivity and lowest channel to channel crosstalk. The amplifier/discriminator output was designed to prevent the outputs from one channel from producing triggers on the inputs of other channels. A number of Radio Frequency design techniques were then applied to prevent signals from other subsystems (e.g. the high voltage power supply, command and data handling board, and Ultraviolet stimulation for the MCP) from generating false events. These techniques enabled us to operate the board at its highest sensitivity when operated in isolation and at very high sensitivity when placed into the overall system.

  6. High counting rate resistive-plate chamber

    International Nuclear Information System (INIS)

    Peskov, V.; Anderson, D.F.; Kwan, S.

    1993-05-01

    Parallel-plate avalanche chambers (PPAC) are widely used in physics experiments because they are fast ( 5 counts/mm 2 . A resistive-plate chamber (RPC) is similar to the PPAC in construction except that one or both of the electrodes are made from high resistivity (≥10 10 Ω·cm) materials. In practice RPCs are usually used in the spark mode. Resistive electrodes are charged by sparks, locally reducing the actual electric field in the gap. The size of the charged surface is about 10 mm 2 , leaving the rest of the detector unaffected. Therefore, the rate capability of such detectors in the spark mode is considerably higher than conventional spark counters. Among the different glasses tested the best results were obtained with electron type conductive glasses, which obey Ohm's law. Most of the work with such glasses was done with high pressure parallel-plate chambers (10 atm) for time-of-flight measurements. Resistive glasses have been expensive and produced only in small quantities. Now resistive glasses are commercially available, although they are still expensive in small scale production. From the positive experience of different groups working with the resistive glasses, it was decided to review the old idea to use this glass for the RPC. This work has investigated the possibility of using the RPC at 1 atm and in the avalanche mode. This has several advantages: simplicity of construction, high rate capability, low voltage operation, and the ability to work with non-flammable gases

  7. Neutron detector

    Science.gov (United States)

    Stephan, Andrew C [Knoxville, TN; Jardret,; Vincent, D [Powell, TN

    2011-04-05

    A neutron detector has a volume of neutron moderating material and a plurality of individual neutron sensing elements dispersed at selected locations throughout the moderator, and particularly arranged so that some of the detecting elements are closer to the surface of the moderator assembly and others are more deeply embedded. The arrangement captures some thermalized neutrons that might otherwise be scattered away from a single, centrally located detector element. Different geometrical arrangements may be used while preserving its fundamental characteristics. Different types of neutron sensing elements may be used, which may operate on any of a number of physical principles to perform the function of sensing a neutron, either by a capture or a scattering reaction, and converting that reaction to a detectable signal. High detection efficiency, an ability to acquire spectral information, and directional sensitivity may be obtained.

  8. Anisotropic elastic plates

    CERN Document Server

    Hwu, Chyanbin

    2010-01-01

    As structural elements, anisotropic elastic plates find wide applications in modern technology. The plates here are considered to be subjected to not only in plane load but also transverse load. In other words, both plane and plate bending problems as well as the stretching-bending coupling problems are all explained in this book. In addition to the introduction of the theory of anisotropic elasticity, several important subjects have are discussed in this book such as interfaces, cracks, holes, inclusions, contact problems, piezoelectric materials, thermoelastic problems and boundary element a

  9. High loading uranium plate

    International Nuclear Information System (INIS)

    Wiencek, T.C.; Domagala, R.F.; Thresh, H.R.

    1990-01-01

    Two embodiments of a high uranium fuel plate are disclosed which contain a meat comprising structured uranium compound confined between a pari of diffusion bonded ductile metal cladding plates uniformly covering the meat, the meat hiving a uniform high fuel loading comprising a content of uranium compound greater than about 45 Vol. % at a porosity not greater than about 10 Vol. %. In a first embodiment, the meat is a plurality of parallel wires of uranium compound. In a second embodiment, the meat is a dispersion compact containing uranium compound. The fuel plates are fabricated by a hot isostatic pressing process

  10. MUST detector

    International Nuclear Information System (INIS)

    Blumenfeld, Y.; Auger, F.; Sauvestre, J.E.

    1999-01-01

    The IPN-Orsay, in collaboration with the SPhN-Saclay and the DPTA Bruyeres, has built an array of 8 telescopes based on Si-strip technology for the study of direct reactions induced by radioactive beams. The detectors are described, along with the compact high density VXI electronics and the stand-alone data acquisition system developed in the laboratory. One telescope was tested using an 40 Ar beam and the measured performances are discussed. (authors)

  11. Radiation detector

    Energy Technology Data Exchange (ETDEWEB)

    Ohata, Shuichi; Takeuchi, Yoji

    1968-10-30

    Herein disclosed is an ionization chamber the airtightness of which can be readily tested. The ionization chamber is characterized in that a small amount of helium gas is filled in the chamber in combination with other ionization gases such as argon gas, xenon gas and the like. Helium leakage from the chamber is measured by a known helium gas sensor in a vacuum vessel. Hence the long term drift of the radiation detector sensitivity may be determined.

  12. Storage of strawberries (Fragaria ananassa L. cv. ‘Oso Grande’, subjected to 1-MCP - doi: 10.4025/actascitechnol.v34i3.8790

    Directory of Open Access Journals (Sweden)

    Polyanna Alves Silva

    2012-05-01

    Full Text Available This study aimed to investigate the influence of 1 - methylcyclopropene (1-MCP on the substances involved in the softening of strawberry, cultivar Oso Grande, stored at room temperature, from the municipality of Itutinga, State of Minas Gerais. The parameters evaluated were: firmness, total pectin, percentage of solubilization, activities of the enzymes pectinmethylesterase (PME (EC 3.1.1.11 and polygalacturonase (PG (EC 3.2.1.15. It was concluded that 1-MCP delayed the softening of the fruits, since the fruits that were treated with 1-MCP after storage, have shown greater firmness, lower activities of PG and PME, and lower contents of total pectin, soluble pectin and percentage of solubilization. 

  13. Increased cerebrospinal fluid levels of cytokines monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-1β (MIP-1β) in patients with amyotrophic lateral sclerosis.

    Science.gov (United States)

    Martínez, H R; Escamilla-Ocañas, C E; Camara-Lemarroy, C R; González-Garza, M T; Moreno-Cuevas, J; García Sarreón, M A

    2017-10-10

    Neuroinflammation has recently been described in amyotrophic lateral sclerosis (ALS). However, the precise role of such proinflammatory cytokines as monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-1β (MIP-1β) in ALS has not yet been determined. In this study, we determined cerebrospinal fluid (CSF) MCP-1 and MIP-1β levels and assessed their association with the duration and severity of ALS. Concentrations of MCP-1 and MIP-1β were determined in the CSF of 77 patients diagnosed with ALS and 13 controls. Cytokine levels were analysed in relation to ALS duration (12months) and severity (30points on the ALS Functional Rating Scale administered at hospital admission). Higher CSF MIP-1β (10.68pg/mL vs. 4.69pg/mL, P<.0001) and MCP-1 (234.89pg/mL vs. 160.95pg/mL, P=.011) levels were found in the 77 patients with ALS compared to controls. There were no differences in levels of either cytokine in relation to disease duration or severity. However, we did observe a significant positive correlation between MIP-1β and MCP-1 in patients with ALS. The increase in MIP-1β and MCP-1 levels suggests that these cytokines may have a synergistic effect on ALS pathogenesis. However, in our cohort, no association was found with either the duration or the clinical severity of the disease. Copyright © 2017 Sociedad Española de Neurología. Publicado por Elsevier España, S.L.U. All rights reserved.

  14. One-dimensional position readout from microchannel plates

    International Nuclear Information System (INIS)

    Connell, K.A.; Przybylski, M.M.

    1982-01-01

    The development of a one-dimensional position readout system with microchannel plates, is described, for heavy ion detectors for use in a particle time-of-flight telescope and as a position sensitive device in front of an ionisation counter at the Nuclear Structure Facility. (U.K.)

  15. Heat insulating plates

    Energy Technology Data Exchange (ETDEWEB)

    Allan, J.A.F.

    1976-10-28

    Micro-porous insulation plates are dealt with, for example, how they are used in the insulation of heat storage devices. Since one side of such plates is exposed to a temperature of over 700/sup 0/C, a shrinkage of the glass texture of the covering can occur, which can exceed the shrinkage of the inner micro-porous material, so that cracks and splits in the high temperature side of the covering can come about. The task of the invention is to design the plate in such a way as to prevent this from happening. For this purpose the plate is provided, according to invention specifications, with flutes, waves, ribs, waffle or grid patterns and the covering is set into the recesses originating from this.

  16. Create Your Plate

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  17. Create Your Plate

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  18. Create Your Plate

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  1. Create Your Plate

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  11. Humvee Armor Plate Drilling

    National Research Council Canada - National Science Library

    2004-01-01

    When drilling holes in hard steel plate used in up-armor kits for Humvee light trucks, the Anniston Army Depot, Anniston, Alabama, requested the assistance of the National Center for Defense Manufacturing and Machining (NCDMM...

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  14. Create Your Plate

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  15. Nuclear NF-κB p65 in peripheral blood mononuclear cells correlates with urinary MCP-1, RANTES and the severity of type 2 diabetic nephropathy.

    Directory of Open Access Journals (Sweden)

    Bin Yi

    Full Text Available AIMS: To investigate if nuclear NF-κB p65 expression in ex vivo isolated peripheral blood mononuclear cells correlates with urinary MCP-1 or RANTES and the severity of type 2 diabetic nephropathy. METHODS: According to their urinary albumin-to-creatinine ratio (uACR, 107 patients with type 2 diabetes (eGFR >60 ml/min were divided into normal albuminuria group (DN0 group, 38 cases, microalbuminuria group (DN1 group, 38 cases, and macroalbuminuria group (DN2 group, 31 cases, compared with matched healthy normal control group (NC group, 30 cases. Nuclear NF-κB p65 protein expression levels in peripheral blood mononuclear cells were detected by western blotting. Real-time quantitative polymerase chain reaction was used to detect NF-κB p65 mRNA expression and ELISA assay was used to detect the levels of urinary MCP-1 and RANTES. RESULTS: Nuclear NF-κB p65 protein and NF-κB p65 mRNA expression levels in peripheral blood mononuclear cells, urinary MCP-1/Cr and RANTES/Cr were all significantly higher in all diabetes groups as compared with NC group. In particular, the increase of nuclear NF-κB p65 protein and NF-κB p65 mRNA expressions, urinary MCP-1/Cr and RANTES/Cr all correlated with the severity of type 2 diabetic nephropathy as indicated by the increase in uACR. Pearson correlation analysis indicated that both urinary MCP-1/Cr and RANTES/Cr were positively correlated with nuclear NF-κB p65 protein or NF-κB p65 mRNA levels. Stepwise multiple regression analysis showed that nuclear NF-κB p65 protein or NF-κB p65 mRNA was an independent variable for urinary MCP-1/Cr, and MCP-1/Cr and RANTES/Cr were two independent variables for uACR. CONCLUSION: Our research demonstrates that nuclear NF-κB p65 protein and mRNA expressions in ex vivo isolated peripheral blood mononuclear cells well correlate with urinary MCP-1/Cr, RANTES/Cr and the severity of type 2 diabetic nephropathy.

  16. Qualidade de caqui 'Rama forte' após armazenamento refrigerado, influenciada pelos tratamentos 1-MCP e/ou CO2

    Directory of Open Access Journals (Sweden)

    João Peterson Pereira Gardin

    2012-12-01

    Full Text Available Avaliaram-se os efeitos dos tratamentos com CO2 e 1-MCP (1-metilciclopropeno sobre a adstringência (índice de tanino, firmeza da polpa e distúrbios da epiderme em caqui 'Rama Forte'. Frutos foram tratados com 1-MCP por 24 h, logo após a colheita e/ou com alto CO2 (70% por 24 ou 48 h, um dia após a colheita ou após o armazenamento refrigerado (AR. Os caquis foram armazenados sob atmosfera modificada a 0 ºC, por 45 dias, e a seguir mantidos a 23 ºC, por 9 dias. Frutos-controle (não tratados com 1-MCP nem com CO2 amoleceram em três dias e perderam aproximadamente 50% da adstringência em 6 dias após o AR. A exposição ao CO2 acelerou a redução da adstringência. Esse efeito do CO2 foi menor em frutos tratados com 1-MCP, especialmente quando o CO2 foi aplicado após o AR, por apenas 24 h. O tratamento com 1-MCP inibiu o amolecimento e a redução da adstringência, especialmente nos frutos não tratados com CO2. O amolecimento de frutos tratados com 1-MCP foi maior quando a exposição ao CO2 ocorreu antes do AR. A combinação dos tratamentos com 1-MCP e alto CO2 reduziu a incidência de podridões e manchas translúcidas, mas não alterou o desenvolvimento de pintas pretas ('estrias'. Os resultados indicam que é possível induzir perda da adstringência sem excessiva perda da firmeza da polpa de caquis 'Rama Forte' após o AR pela associação dos tratamentos com 1-MCP logo após a colheita e alto CO2 após o AR.

  17. BAO Plate Archive Project

    Science.gov (United States)

    Mickaelian, A. M.; Gigoyan, K. S.; Gyulzadyan, M. V.; Paronyan, G. M.; Abrahamyan, H. V.; Andreasyan, H. R.; Azatyan, N. M.; Kostandyan, G. R.; Samsonyan, A. L.; Mikayelyan, G. A.; Farmanyan, S. V.; Harutyunyan, V. L.

    2017-12-01

    We present the Byurakan Astrophysical Observatory (BAO) Plate Archive Project that is aimed at digitization, extraction and analysis of archival data and building an electronic database and interactive sky map. BAO Plate Archive consists of 37,500 photographic plates and films, obtained with 2.6m telescope, 1m and 0.5m Schmidt telescopes and other smaller ones during 1947-1991. The famous Markarian Survey (or the First Byurakan Survey, FBS) 2000 plates were digitized in 2002-2005 and the Digitized FBS (DFBS, www.aras.am/Dfbs/dfbs.html) was created. New science projects have been conducted based on this low-dispersion spectroscopic material. Several other smaller digitization projects have been carried out as well, such as part of Second Byurakan Survey (SBS) plates, photographic chain plates in Coma, where the blazar ON 231 is located and 2.6m film spectra of FBS Blue Stellar Objects. However, most of the plates and films are not digitized. In 2015, we have started a project on the whole BAO Plate Archive digitization, creation of electronic database and its scientific usage. Armenian Virtual Observatory (ArVO, www.aras.am/Arvo/arvo.htm) database will accommodate all new data. The project runs in collaboration with the Armenian Institute of Informatics and Automation Problems (IIAP) and will continues during 4 years in 2015-2018. The final result will be an Electronic Database and online Interactive Sky map to be used for further research projects. ArVO will provide all standards and tools for efficient usage of the scientific output and its integration in international databases.

  18. Focal plane detector for QDD spectrography in Institute of Nuclear Study and detector for SMART 2nd focal plane in RIKEN

    Energy Technology Data Exchange (ETDEWEB)

    Fuchi, Yoshihide [Tokyo Univ., Tanashi (Japan). Inst. for Nuclear Study

    1996-09-01

    The focal plane detector for QDD spectrography in Institute of Nuclear Study was composed of drift space and a proportional counter tube, and the latter is composed of position detector and two delta E detector for recognizing the particles. In this detector, a uniform parallel electric field can be obtained by placing a guard plate at the same height as that of a drift plate outer place of the detector. On the other hand, the detector for SMART 2nd focal plate in RIKEN is composed of drift space and a single wire proportional counter, and has two cathode read out single wire drift counters set so as to hold the focal plane. (G.K.)

  19. Temporal resolution technology of a soft X-ray picosecond framing camera based on Chevron micro-channel plates gated in cascade

    Energy Technology Data Exchange (ETDEWEB)

    Yang Wenzheng [State Key Laboratory of Transient Optics and Photonics, Xi' an Institute of Optics and Precision Mechanics, Chinese Academy of Sciences, Xi' an 710119 (China)], E-mail: ywz@opt.ac.cn; Bai Yonglin; Liu Baiyu [State Key Laboratory of Transient Optics and Photonics, Xi' an Institute of Optics and Precision Mechanics, Chinese Academy of Sciences, Xi' an 710119 (China); Bai Xiaohong; Zhao Junping; Qin Junjun [Key Laboratory of Ultra-fast Photoelectric Diagnostics Technology, Xi' an Institute of Optics and Precision Mechanics, Chinese Academy of Sciences, Xi' an 710119 (China)

    2009-09-11

    We describe a soft X-ray picosecond framing camera (XFC) based on Chevron micro-channel plates (MCPs) gated in cascade for ultra-fast process diagnostics. The micro-strip lines are deposited on both the input and the output surfaces of the Chevron MCPs and can be gated by a negative (positive) electric pulse on the first (second) MCP. The gating is controlled by the time delay T{sub d} between two gating pulses. By increasing T{sub d}, the temporal resolution and the gain of the camera are greatly improved compared with a single-gated MCP-XFC. The optimal T{sub d}, which results in the best temporal resolution, is within the electron transit time and transit time spread of the MCP. Using 250 ps, {+-}2.5 kV gating pulses, the temporal resolution of the double-gated Chevron MCPs camera is improved from 60 ps for the single-gated MCP-XFC to 37 ps for T{sub d}=350 ps. The principle is presented in detail and accompanied with a theoretic simulation and experimental results.

  20. Genetic polymorphisms of RANTES, IL1-A, MCP-1 and TNF-A genes in patients with prostate cancer

    International Nuclear Information System (INIS)

    Sáenz-López, Pablo; Carretero, Rafael; Cózar, José Manuel; Romero, José Maria; Canton, Julia; Vilchez, José Ramón; Tallada, Miguel; Garrido, Federico; Ruiz-Cabello, Francisco

    2008-01-01

    Inflammation has been implicated as an etiological factor in several human cancers, including prostate cancer. Allelic variants of the genes involved in inflammatory pathways are logical candidates as genetic determinants of prostate cancer risk. The purpose of this study was to investigate whether single nucleotide polymorphisms of genes that lead to increased levels of pro-inflammatory cytokines and chemokines are associated with an increased prostate cancer risk. A case-control study design was used to test the association between prostate cancer risk and the polymorphisms TNF-A-308 A/G (rs 1800629), RANTES-403 G/A (rs 2107538), IL1-A-889 C/T (rs 1800587) and MCP-1 2518 G/A (rs 1024611) in 296 patients diagnosed with prostate cancer and in 311 healthy controls from the same area. Diagnosis of prostate cancer was significantly associated with TNF-A GA + AA genotype (OR, 1.61; 95% CI, 1.09–2.64) and RANTES GA + AA genotype (OR, 1.44; 95% CI, 1.09–2.38). A alleles in TNF-A and RANTES influenced prostate cancer susceptibility and acted independently of each other in these subjects. No epistatic effect was found for the combination of different polymorphisms studied. Finally, no overall association was found between prostate cancer risk and IL1-A or MCP-1 polymorphisms. Our results and previously published findings on genes associated with innate immunity support the hypothesis that polymorphisms in proinflammatory genes may be important in prostate cancer development

  1. Three-dimensional supercapacitors composed of Ba{sub 0.65}Sr{sub 0.35}TiO{sub 3} (BST)/NiSi{sub 2}/silicon microchannel plates

    Energy Technology Data Exchange (ETDEWEB)

    Liu Tao; Zhang Huayan; Wang Fei; Shi Jing; Ci Pengliang [Laboratory of Polar Materials and Devices, Ministry of Education, and Department of Electronic Engineering, East China Normal University, 500 Dongchuan Road, Minhang District, Shanghai 200241 (China); Wang Lianwei, E-mail: lwwang@ee.ecnu.edu.cn [Laboratory of Polar Materials and Devices, Ministry of Education, and Department of Electronic Engineering, East China Normal University, 500 Dongchuan Road, Minhang District, Shanghai 200241 (China); Ge Shuli; Wang Qingjiang [Department of Chemistry, East China Normal University, Shanghai 200241 (China); Chu, Paul K. [Department of Physics and Material Sciences, City University of Hong Kong, Tat Chee Avenue, Kowloon (Hong Kong)

    2011-03-25

    Three-dimensional (3D) supercapacitors consisting of Ba{sub 0.65}Sr{sub 0.35}TiO{sub 3} (BST)/NiSi{sub 2}/silicon microchannel plate (MCP) stacked structure have been fabricated. The silicon MCP produced by electrochemical etching is utilized as a backbone of the 3D structure on which a nickel silicide current collector layer and Ba{sub 0.65}Sr{sub 0.35}TiO{sub 3} dielectric layer are deposited successively by electroless plating and the sol-gel method, respectively. The morphology and structure of the 3D BST/NiSi{sub 2}/Si-MCP structure are characterized by scanning electron microscopy (SEM) and X-ray diffraction (XRD) and the electrochemical properties are determined by cyclic voltammetry (CV) and chronopotentiometry. The structure exhibits excellent capacitive behavior with a maximum capacitance of 784 F g{sup -1}. After 700 charging/discharging cycles, the C{sub f} decreases slightly with only a 5.7% loss and is stable after more than 700 cycles. The BST/NiSi{sub 2}/Si-MCP 3D structure is a potential supercapacitor in industrial applications.

  2. Smoke detectors

    International Nuclear Information System (INIS)

    Fung, C.K.

    1981-01-01

    This describes a smoke detector comprising a self-luminous light source and a photosensitive device which is so arranged that the light source is changed by the presence of smoke in a detecting region. A gaseous tritium light source is used. This consists of a borosilicate glass bulb with an internal phosphor coating, filled with tritium gas. The tritium emits low energy beta particles which cause the phosphor to glow. This is a reliable light source which needs no external power source. The photosensitive device may be a phototransistor and may drive a warning device through a directly coupled transistor amplifier. (U.K.)

  3. Performance of a parallel plate volume cell prototype for a fast iron/gas calorimeter

    International Nuclear Information System (INIS)

    Bizzeti, A.; Civinini, C.; D'alessandro, R.; Ferrando, A.

    1993-01-01

    We present the first test of the application of the parallel plate chamber principles for the design of a very fast and radiation-hard iron/gas sampling calorimeter, suitable for very forward regions in detectors for LBC; based on the use of thick iron plates as electrodes. We have built a one cell prototype consisting of three parallel thick iron plates (117 mn each). Results on efficiencies and mean collected charge for minimum ionizing particles with different gases are presented. (Author)

  4. The Cosmic Ray Tracking (CRT) detector system

    International Nuclear Information System (INIS)

    Bernloehr, K.; Gamp, S.; Hermann, G.; Hofmann, W.; Kihm, T.; Knoeppler, J.; Leffers, G.; Matheis, V.; Panter, M.; Trunk, U.; Ulrich, M.; Wolf, T.; Zink, R.; Heintze, J.

    1996-01-01

    The Cosmic Ray Tracking (CRT) project represents a study on the use of tracking detectors of the time projection chamber type to detect secondary cosmic ray particles in extensive air showers. In reconstructing the arrival direction of the primary cosmic ray particles, the CRT detectors take advantage of the angular correlation of secondary particles with the cosmic rays leading to these air showers. In this paper, the detector hardware including the custom-designed electronics system is described in detail. A CRT detector module provides an active area of 2.5 m 2 and allows to measure track directions with a precision of 0.4 circle . It consists of two circular drift chambers of 1.8 m diameter with six sense wires each, and a 10 cm thick iron plate between the two chambers. Each detector has a local electronics box with a readout, trigger, and monitoring system. The detectors can distinguish penetrating muons from other types of charged secondaries. A large detector array could be used to search for γ-ray point sources at energies above several TeV and for studies of the cosmic-ray composition. Ten detectors are in operation at the site of the HEGRA air shower array. (orig.)

  5. Small area detectors at the European XFEL

    Science.gov (United States)

    Turcato, M.; Gessler, P.; Hauf, S.; Kuster, M.; Meyer, M.; Nordgren, J.; Sztuk-Dambietz, J.; Youngman, C.

    2014-05-01

    The detectors to be used at the European XFEL have to deal with the unique time structure of the machine, delivering up to 2700 pulses, with a repetition rate of 4.5 MHz, ten times per second, the very high photon flux and the need to combine single-photon sensitivity and a large dynamic range. This represents a challenge not only for the large-area 2D imaging detectors but also for the smaller-area detectors and makes the use of standard commercial devices impossible. Dedicated solutions are therefore envisaged for small imaging- or strip-detectors. In this contribution the focus is put on two particular small-area detector solutions which are planned to be used at the European XFEL, a strip detector for hard X-rays (with energy 3 < E < 25 keV) and an imaging detector for soft X-rays (0.25 < E < 3 keV). Hard X-rays photon-beam diagnostics as well as hard X-ray absorption and emission spectroscopy at the European XFEL make use of strip detectors as detectors for beam spectrometers or as energy-dispersive detectors in combination with an energy-dispersive element. The European XFEL is establishing cooperation with the Paul Scherrer Institute in Villigen to develop a new version of the Gotthard detector best suited to the European XFEL needs. The use case and the required detector specifications are illustrated. Starting from the present detector version, the modifications planned to adapt it to the European XFEL running conditions are described. These include the capability of running at an increased rate and to provide a veto signal to the large 2D imaging detectors, in order to be able to remove non-interesting images already at early stages of the DAQ system. In another particular application, resonant inelastic X-ray scattering, a Micro-Channel Plate detector matched to a delay-line readout is foreseen to be used. In this case the European XFEL is aiming for a highly customized solution provided by the German company Surface Concept. The use case is described

  6. Cadmium plating replacements

    Energy Technology Data Exchange (ETDEWEB)

    Nelson, M.J.; Groshart, E.C.

    1995-03-01

    The Boeing Company has been searching for replacements to cadmium plate. Two alloy plating systems seem close to meeting the needs of a cadmium replacement. The two alloys, zinc-nickel and tin-zinc are from alloy plating baths; both baths are neutral pH. The alloys meet the requirements for salt fog corrosion resistance, and both alloys excel as a paint base. Currently, tests are being performed on standard fasteners to compare zinc-nickel and tin-zinc on threaded hardware where cadmium is heavily used. The Hydrogen embrittlement propensity of the zinc-nickel bath has been tested, and just beginning for the tin-zinc bath. Another area of interest is the electrical properties on aluminum for tin-zinc and will be discussed. The zinc-nickel alloy plating bath is in production in Boeing Commercial Airplane Group for non-critical low strength steels. The outlook is promising that these two coatings will help The Boeing Company significantly reduce its dependence on cadmium plating.

  7. Silicon Microchannel Plate Large Area UV Detector, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — To address the NASA need for high-quantum-efficiency, high-resolution, low-cost photodetectors for the far-UV spectral range, Physical Optics Corporation (POC)...

  8. Bending and stretching of plates

    CERN Document Server

    Mansfield, E H; Hemp, W S

    1964-01-01

    The Bending and Stretching of Plates deals with elastic plate theory, particularly on small- and large-deflexion theory. Small-deflexion theory concerns derivation of basic equations, rectangular plates, plates of various shapes, plates whose boundaries are amenable to conformal transformation, plates with variable rigidity, and approximate methods. Large-deflexion theory includes general equations and some exact solutions, approximate methods in large-deflexion theory, asymptotic large-deflexion theories for very thin plates. Asymptotic theories covers membrane theory, tension field theory, a

  9. Chemokine MCP1/CCL2 and RANTES/CCL5 gene polymorphisms influence Henoch–Schönlein purpura susceptibility and severity

    Directory of Open Access Journals (Sweden)

    Hsin-Hui Yu

    2015-04-01

    Conclusion: Our results support the fact that chemokines play important roles in the pathogenesis of HSP. MCP1/CCL2 gene polymorphisms were associated with susceptibility for HSP. RANTES/CCL5 gene polymorphisms may be related to disease severity and HSP nephritis.

  10. Concentrações de IL-6, TNF-α e MCP-1 em crianças com excesso de massa corporal

    Directory of Open Access Journals (Sweden)

    Juliano Magalhães Guedes

    2015-08-01

    Full Text Available O objetivo desta revisão sistemática foi verificar a relação das concentrações de IL-6, TNF-α e MCP-1 em crianças com excesso de massa corporal. As bases de dados investigadas PUBMED, SciELO, LILACS e Periódico Capes foram consultadas retrospectivamente para os últimos seis anos (2009 a 2014 utilizando combinações de palavras chaves como inflamação, IL-6, TNF-α, MCP-1 combinadas com crianças e escolares. Foram analisados 21 artigos. Foi encontrado associação entre sobrepeso/obesidade com IL-6, TNF-α e MCP-1 em 73,3% (11/15, 80% (12/15 e 60% (3/5 dos estudos que analisaram tais marcadores, respectivamente. Crianças com excesso de massa corporal possuem concentrações elevadas de IL-6, TNF-α e MCP-1 resultando em inflamação sistêmica crônica e aumentando o risco de desenvolvimento de outras doenças cardiovasculares. 

  11. Relative contributions of decay accelerating factor (DAF), membrane cofactor protein (MCP) and CD59 in the protection of melanocytes from homologous complement

    NARCIS (Netherlands)

    Venneker, G. T.; Vodegel, R. M.; Okada, N.; Westerhof, W.; Bos, J. D.; Asghar, S. S.

    1998-01-01

    Complement regulatory molecules, membrane cofactor protein (MCP), decay accelerating factor (DAF) and CD59, protect body cells from autologous complement. They have wide tissue distribution but nothing is known about the expression of these molecules on human melanocytes. Since melanocytes are lysed

  12. OSIRIS Detectors

    Science.gov (United States)

    Joven, E.; Gigante, J.; Beigbeder, F.

    OSIRIS (Optical System for Imaging and Low-Resolution Integrated Spectroscopy) is an instrument designed to obtain images and low-resolution spectra of astronomical objects in the optical domain (from 365-1000 nm). It will be installed on Day One (2004) in the Nasmyth focus of the 10-m Spanish GTC Telescope. The mosaic is composed of two abuttable 2Kx4K CCDs to yield a total of 4Kx4K pixels, 15 μm/pixel, 0.1252 plate scale. The arrangement allows the linking of a classical ARC-GenII controller to a PMC frame-grabber, plugged into a VME-CPU card, where a RTOS (VxWorks from Wind River) is running. Some tests and results, carried out with a couple of MAT44-82 engineering grade devices at room temperature, are given.

  13. Space-charge limitation of avalanche growth in narrow-gap resistive plate chambers

    CERN Document Server

    Williams, M C S

    2004-01-01

    A big advance in resistive plate chamber technology happened in 1996 with the advent of the multigap resistive plate chamber (MRPC). The MRPC allows us to easily construct detectors with many small gas gaps and thus we obtain good timing together with high detection efficiency. Using this technology, it is now common to build detectors with gas gaps of 200-300 mum in width. This paper examines space-charge limited avalanche growth; this becomes a dominant effect for narrow gap resistive plate chambers. This effect controls gas gain and explains the reason for the excellent behaviour of MRPCs built with this gas gap.

  14. Radiation detector

    International Nuclear Information System (INIS)

    Conrad, B.; Finkenzeller, J.; Kiiehn, G.; Lichtenberg, W.

    1984-01-01

    In an exemplary embodiment, a flat radiation beam is detected having a common electrode disposed parallel to the beam plane at one side and a common support with a series of individual conductors providing electrodes opposite successive portions of the common electrode and lying in a plane also parallel to the beam plane. The beam may be fan-shaped and the individual electrodes may be aligned with respective ray paths separated by uniform angular increments in the beam plane. The individual conductors and the connection thereof to the exterior of the detector housing may be formed on an insulator which can be folded into a T-shape for leading the supply conductors for alternate individual conductors toward terminals at opposite sides of the chamber

  15. Particle detectors

    CERN Document Server

    Hilke, Hans Jürgen; Joram, Christian; CERN. Geneva

    1991-01-01

    Lecture 5: Detector characteristics: ALEPH Experiment cut through the devices and events - Discuss the principles of the main techniques applied to particle detection ( including front-end electronics), the construction and performance of some of the devices presently in operartion and a few ideas on the future performance. Lecture 4-pt. b Following the Scintillators. Lecture 4-pt. a : Scintillators - Used for: -Timing (TOF, Trigger) - Energy Measurement (Calorimeters) - Tracking (Fibres) Basic scintillation processes- Inorganic Scintillators - Organic Scintil - Discuss the principles of the main techniques applied to particle detection ( including front-end electronics), the construction and performance of some of the devices presently in operation and a fiew ideas on future developpement session 3 - part. b Following Calorimeters lecture 3-pt. a Calorimeters - determine energy E by total absorption of charged or neutral particles - fraction of E is transformed into measurable quantities - try to acheive sig...

  16. Smoke detectors

    International Nuclear Information System (INIS)

    Bryant, J.

    1979-01-01

    An ionization smoke detector consisting of two electrodes defining an ionization chamber permitting entry of smoke, a radioactive source to ionize gas in the chamber and a potential difference applied across the first and second electrodes to cause an ion current to flow is described. The current is affected by entry of smoke. An auxiliary electrode is positioned in the ionization chamber between the first and second electrodes, and it is arranged to maintain or create a potential difference between the first electrode and the auxiliary electrode. The auxiliary electrode may be used for testing or for adjustment of sensitivity. A collector electrode divides the chamber into two regions with the auxiliary electrode in the outer sensing region. (U.K.)

  17. Ionization detector

    International Nuclear Information System (INIS)

    Solomon, E.E.

    1980-01-01

    A safe and reliable apparatus for detecting products of combustion and aerosols in the atmosphere was developed which uses a beta source. It is easy to adjust for optimum performance. The ionization detector comprises a double chamber; one of the chambers is the basic sensing chamber. The sensing chamber is ported to both the secondary chambers to account for slow ambient changes in the atmosphere outside of the chamber. The voltages from the ionization chamber are adjusted with electrodes in each chamber. The ionization chamber contains baffles to direct the air to be sensed as well as an electrostatic screen. A unique electronic circuit provides an inexpensive and reliable means for detecting the signal change which occurs in the ionization chamber. The decision level of the alarm circuit can be adjusted to allow for any desired sensitivity. (D.N.)

  18. Prototype Performance of Novel Muon Telescope Detector at STAR

    International Nuclear Information System (INIS)

    Ruan, L.

    2008-01-01

    Research on a large-area, cost-effective Muon Telescope Detector (MTD) has been carried out for RHIC and for next generation detectors at future QCD Lab. We utilize state-of-the-art multi-gap resistive plate chambers with large modules and long readout strips in detector design. The results from cosmic ray and beam test will be presented to address intrinsic timing and spatial resolution for a Long-MRPC. The prototype performance of a novel muon telescope detector at STAR will be reported, including muon identification capability, timing and spatial resolution

  19. Prototype performance of novel muon telescope detector at STAR

    International Nuclear Information System (INIS)

    Ruan, L.; Ames, V.

    2011-01-01

    Research on a large-area, cost-effective Muon Telescope Detector has been carried out for RHIC and for next generation detectors at future QCD Lab. We utilize state-of-the-art multi-gap resistive plate chambers with large modules and long readout strips in detector design. The results from cosmic ray and beam test will be presented to address intrinsic timing and spatial resolution for a Long-MRPC. The prototype performance of a novel muon telescope detector at STAR will be reported, including muon identification capability, timing and spatial resolution. (author)

  20. Plating on Zircaloy-2

    International Nuclear Information System (INIS)

    Dini, J.W.; Johnson, H.R.; Jones, A.

    1979-03-01

    Zircaloy-2 is a difficult alloy to coat with an adherent electroplate because it easily forms a tenacious oxide film in air and aqueous solutions. Procedures reported in the literature and those developed at SLL for surmounting this problem were investigated. The best results were obtained when specimens were first etched in either an ammonium bifluoride/sulfuric acid or an ammonium bifluoride solution, plated, and then heated at 700 0 C for 1 hour in a constrained condition. Machining threads in the Zircaloy-2 for the purpose of providing sites for mechanical interlocking of the plating also proved satisfactory

  1. NICKEL PLATING PROCESS

    Science.gov (United States)

    Hoover, T.B.; Zava, T.E.

    1959-05-12

    A simplified process is presented for plating nickel by the vapor decomposition of nickel carbonyl. In a preferred form of the invention a solid surface is nickel plated by subjecting the surface to contact with a mixture containing by volume approximately 20% nickel carbonyl vapor, 2% hydrogen sulfide and .l% water vapor or 1% oxygen and the remainder carbon dioxide at room temperature until the desired thickness of nickel is obtained. The advantage of this composition over others is that the normally explosive nickel carbonyl is greatly stabilized.

  2. Hydrodynamics of a flexible plate between pitching rigid plates

    Science.gov (United States)

    Kim, Junyoung; Kim, Daegyoum

    2017-11-01

    The dynamics of a flexible plate have been studied as a model problem in swimming and flying of animals and fluid-structure interaction of plants and flags. Motivated by fish schooling and an array of sea grasses, we investigate the dynamics of a flexible plate closely placed between two pitching rigid plates. In most studies on passive deformation of the flexible plate, the plate is immersed in a uniform flow or a wavy flow. However, in this study, the flexible plate experiences periodic deformation by the oscillatory flow generated by the prescribed pitching motion of the rigid plates. In our model, the pitching axes of the rigid plates and the clamping position of the flexible plate are aligned on the same line. The flexible plate shows various responses depending on length and pitching frequency of rigid plates, thickness of a flexible plate, and free-stream velocity. To find the effect of each variable on the response of the flexible plate, amplitude of a trailing edge and modal contribution of a flapping motion are compared, and flow structure around the flexible plate is examined.

  3. Comparison of the Effect of 1-MCP and Low-Pressure Air on Shelflife of Strawberry Fruit (Fragaria ananassa cv. Camarossa

    Directory of Open Access Journals (Sweden)

    B. Modares

    2013-10-01

    Full Text Available Strawberry (Fragaria×ananassa has tasteful, fragrant and nutritious fruits. But, because of delicate texture and high metabolic activities of the fruits at maturity, are very sensitive and easily decayed, and thus have short shelflife. Ethylene is one of the main causes of postharvest fruit losses, which could reduce the shelflife of strawberry. Therefore, an experiment was carried out to examine the effect of 1 µL/L 1-MCP treatment and low-pressure air pretreatment at 0.2 atm in 2 hours on apparent and physicochemical characteristics of strawberry fruit, cultivar Camarossa, during storage in cold store. The study was performed as split plots in time, based on complete randomized design with 3 replications. The results showed that the highest marketability (90%, fruit firmness (7.95 N, titrable organic acids (1.15 g/100 cc, vitamin C (78.13 mg/100 cc and total soluble solids (10.48 % and the lowest amount of apparent decay (13.3 %, acidity (3.63 and taste index (9.04 were obtained in 1-MCP and low-pressure air treatments, which shows the effect of treatments on reducing the rate of biochemical variations in fruit texture. Correlation coefficients between all treatments were significant (P≤0.01. Meanwhile, the positive effect of 1-MCP on appearance and studied physicochemical characteristics was more than low-pressure air pretreatment. Even, the combination of these two treatments had no significant difference with 1-MCp treatment alone. In general, this observation depicts the more positive and significant effect of 1-MCP treatment in delaying the maturity and improving the qualitative traits of strawberry fruits after being stored in cold storage.

  4. AOPPs Induce MCP-1 Expression by Increasing ROS-Mediated Activation of the NF-κB Pathway in Rat Mesangial Cells: Inhibition by Sesquiterpene Lactones

    Directory of Open Access Journals (Sweden)

    Jian-Cheng Wang

    2013-12-01

    Full Text Available Background: Monocyte chemoattractant protein-1 (MCP-1 plays an important role in extracellular matrix accumulation through macrophage recruitment and activation in the development and progression of diabetic nephropathy. Therefore, this study examined whether advanced oxidation protein products (AOPPs are involved in nuclear factor-κB (NF-κB activation and MCP-1 mRNA and protein expression in mesangial cells (MCs and evaluated the effects of derivatives of sesquiterpene lactones (SLs on AOPP-induced renal damage. Methods: MCP-1 mRNA and protein expression in MCs were determined by quantitative real-time PCR and ELISA, respectively. The level of intracellular reactive oxygen species (ROS was determined by flow cytometry. The protein expression of tubulin, P47, NF-κB p65, phospho-NF-κB p65, IκB, phospho-IκB, IKKß and phospho-IKKß was evaluated by Western blot. Results: AOPPs caused oxidative stress in MCs and activated the NF-κB pathway by inducing IκBa phosphorylation and degradation. Inhibition of ROS by SOD (ROS inhibitor blocked the AOPP-mediated NF-κB pathway. Moreover, the inhibition of AOPP-induced overproduction of MCP-1 mRNA and protein was associated with inhibition of IκBa degradation by SLs. Conclusion: AOPPs induce MCP-1 expression by activating the ROS/NF-κB pathway and can be inhibited by SLs. These findings may provide a novel approach to treat inflammatory and immune renal diseases, including diabetic nephropathy.

  5. Contribution of radon daughters plated-out in a cylindrical device by track-technique

    Energy Technology Data Exchange (ETDEWEB)

    Hafez, A.F. (Alexandria Univ. (Egypt). Dept. of Physics); Kotb, M.A. (Alexandria Univ. (Egypt). Biophysics Dept.); Toth-Szilagyi, M. (Magyar Tudomanyos Akademia, Debrecen (Hungary). Atommag Kutato Intezete)

    1991-01-01

    CR-39 plastic nuclear track detector is used to measure the fraction of alpha-particle tracks due to radon daughters activities plated-out on the internal walls of a cylindrical-shaped plastic can. Radium chloride solution is used as a radon source, the exposure time is ranged from 4 hours to 3 days. To assess the percentage of plate-out effect on CR-39 nuclear track detector, two different methods were used. In one experiment, a few circular parallel pairs of CR-39 sheets were hanged in the can device. In the other experiment, the estimation of the plate-out effect has been performed, after exposure to the radon source, by detecting tracks with a second unexposed sheet placed in close contact to the exposed wall and detectors. In the two methods, it was found that the chemically etched tracks related to plated-out activities contribute about 50% of the measured alpha-particles tracks. (orig.).

  6. Silicon radiation detectors

    International Nuclear Information System (INIS)

    Lutz, G.

    1995-01-01

    An introduction to and an overview of function principles and properties of semiconductor radiation detectors is attempted. The paper is addressed to people interested in detector development but not already experts in the field of semiconductor detectors. (orig.)

  7. Create Your Plate

    Medline Plus

    Full Text Available ... meal-planning, . In this section Food Planning Meals Diabetes Meal Plans and a Healthy Diet Create Your Plate Meal Planning for Vegetarian Diets Gluten Free Diets Holiday Meal Planning Cook with Heart-Healthy Foods donate en -- A Future Without Diabetes - a-future-without-diabetes-2.html A Future ...

  8. Create Your Plate

    Medline Plus

    Full Text Available ... tool is not to scale because of the differences in types of vegetables. When creating your plate ... function (data) { $('#survey-errors').remove(); $('.survey-form .form-group .survey-alert-wrap').remove(); if (data.submitSurveyResponse.success == ' ...

  9. Create Your Plate

    Medline Plus

    Full Text Available ... Your Plate Meal Planning for Vegetarian Diets Gluten Free Diets Holiday Meal Planning Cook with Heart-Healthy Foods donate en -- A Future Without Diabetes - a-future-without-diabetes-2.html A Future Without Diabetes Donate towards research today and your gift will be matched. Donate ...

  10. Create Your Plate

    Medline Plus

    Full Text Available ... Planning Meals > Create Your Plate Share: Print Page Text Size: A A A Listen En Español Create ... Type 2 Education Series Hear audio clips and full recordings of past Q&A events at your ...

  11. Create Your Plate

    Medline Plus

    Full Text Available ... 1 Type 2 About Us Online Community Meal Planning Sign In Search: Search More Sites Search ≡ Are ... Fitness Home Food MyFoodAdvisor Recipes Association Cookbook Recipes Planning Meals Diabetes Meal Plans Create Your Plate Gluten ...

  12. Create Your Plate

    Medline Plus

    Full Text Available ... tax-deductible gift today can fund critical diabetes research and support vital diabetes education services that improve the ... effective way to manage your blood glucose levels and lose weight. With this method, you fill your plate with more non-starchy ...

  13. Flat plate collector. Solarflachkollektor

    Energy Technology Data Exchange (ETDEWEB)

    Raab, N

    1979-03-29

    The invention refers to a flat solar collector with an absorber plate, which is arranged on a support and is covered by a transparent window, between which and the plate there is an air space. The previously known structures of this type had the disadvantage that the thermal expansion of the enclosed air caused considerable difficulties. The purpose of the invention is therefore to create a collector, which can be used on the modular system, retains its properties and is safe in spite of the great temperature variations. According to the invention this problem is solved by providing a compensating space in the collector, which is separated by a diaphragm from the airspace between the plate and the covering window. The airspace therefore remains sealed against the atmosphere, so that no dirt, corrosion of the inside and no condensation can reduce the efficiency of the collector. A rise in pressure due to an increase in temperature is immediately reduced by expansion of the diaphragm, which enters the compensation space. In order to increase the pressure in the airspace above the plate for increases in temperature, the compensation space is connected to the atmosphere. The diaphragm can be mirrored on the side towards the absorber, which makes the diaphragm into an insulating element, as it reflects radiated heat from the absorber.

  14. DETECTORS: Vienna - beyond the wire

    International Nuclear Information System (INIS)

    Krammer, Manfred; Regler, Meinhard

    1995-01-01

    presentations. Both ATLAS and CMS demonstrated different approaches to mastering the difficulties of covering large areas with precise detectors capable of resolving consecutive bunches. Proposed techniques included thin gap chambers, straw drift tubes, pressurized drift tubes, resistive plate chambers...

  15. Calibration of detector efficiency of neutron detector

    International Nuclear Information System (INIS)

    Guo Hongsheng; He Xijun; Xu Rongkun; Peng Taiping

    2001-01-01

    BF 3 neutron detector has been set up. Detector efficiency is calibrated by associated particle technique. It is about 3.17 x 10 -4 (1 +- 18%). Neutron yield of neutron generator per pulse (10 7 /pulse) is measured by using the detector

  16. Evaluation of the relative thermoluminescence efficiency of LiF:Mg,Ti and LiF:Mg,Cu,P TL detectors to low-energy heavy ions

    DEFF Research Database (Denmark)

    Gieszczyk, W.; Bilski, P.; Olko, P.

    2013-01-01

    and xenon ion beams, at energies ranging from 5.0 to 9.3 MeV/n. Supra- and sublinear response was found, for the MTS-N and MCP-N, respectively, similarly as observed for γ-rays. However, the level of nonlinearity of response of studied detectors is strongly reduced by increasing values of the ion ionization...... density (no supralinearity for Xe ions, for MTS-N, within calculated uncertainties). The growth of high-temperature TL peaks, with increasing ionization density, was observed for MCP-N, what was not previously reported. At the whole range of applied energies higher efficiencies were noted for MTS......-N, for all ion species. A decrease of the efficiency with decrease of the ion energy was confirmed, for both types of studied detectors. At a given energy, higher efficiency was observed for lighter ions, because of the lower ionization density. Significantly higher decrease of the efficiency was measured...

  17. Conservação pós-colheita de melão Charentais tratado com 1-MCP e armazenado sob refrigeração e atmosfera modificada Postharvest conservation of charentais melons treated with 1-MCP and stored under refrigeration and modified atmosphere

    Directory of Open Access Journals (Sweden)

    Pahlevi A de Souza

    2008-12-01

    Full Text Available Objetivando avaliar a vida útil pós-colheita de melão tipo Charentais (Cucumis melo L. sob refrigeração, tratados com 1-MCP e associado ou não a atmosfera modificada (AM, foram conduzidos dois experimentos em laboratório da Embrapa Agroindústria Tropical, Fortaleza-CE. Os frutos foram provenientes da Agroindústria Nolem Comercial Importadora e Exportadora Ltda, localizada no Agropólo Mossoró Açu-RN. Os frutos foram tratados com 300 e 600 ppb de 1-MCP, em seguida, metade desses frutos foram embalados em filmes plásticos, mantendo-se frutos embalados sem aplicação de 1-MCP nas mesmas condições de armazenamento dos demais. Os melões foram armazenados por 21 dias sendo 14 dias (9±1ºC e 87±5% UR + 7 dias (22±2ºC e 70±5% UR. Em função da aparência externa, a vida útil pós-colheita dos frutos armazenados sob atmosfera modificada, com ou sem tratamento inicial de 1-MCP foi de 21 dias, enquanto que dos frutos tratados inicialmente apenas com 1-MCP foi de 19 dias. A aplicação do 1-MCP proporcionou redução na atividade respiratória e na produção de etileno, e maior retenção da firmeza da polpa, menor perda de massa e melhor aparência externa quando associado a atmosfera modificada. A atmosfera modificada, isoladamente, foi eficiente em reduzir a perda de massa e manter melhor aparência externa.Aiming to evaluate the postharvest shelf life of Charentais melon (Cucumis melo L. stored under refrigeration, the fruits were treated with 1-MCP, associated or not with modified atmosphere (MAP. Two experiments were carried out at the laboratory of Embrapa Agroindústria Tropical in Fortaleza, Brazil, analyzing the chemical and physic quality characteristics. The fruits were obtained at the Agroindústria Nolem Comercial Importadora e Exportadora Ltda, located in Mossoró Açu, Brazil. The fruits were treated with 300 and 600 nL L-1 of 1-MCP, half of those were wrapped in plastic films, which were wrapped without the use of 1

  18. A large area silicon UCN detector with the analysis of UCN polarization

    International Nuclear Information System (INIS)

    Lasakov, M.S.; Serebrov, A.P.; Khusainov, A.Kh.; Pustovoit, A.; Borisov, Yu.V.; Fomin, A.K.; Geltenbort, P.; Kon'kov, O.I.; Kotina, I.M.; Shablii, A.I.; Solovei, V.A.; Vasiliev, A.V.

    2005-01-01

    A silicon UCN detector with an area of 45cm 2 and with a 6 LiF converter was developed at PNPI. The spectral efficiency of the silicon UCN detector was measured by means of a gravitational spectrometer at ILL. The sandwich-type detector from two silicon plates with a 6 LiF converter placed between them was also studied. Using this type of technology the UCN detector with analysis of polarization was developed and tested. The analyzing power of this detector assembly reaches up to 75% for the main part of UCN spectrum. This UCN detector with analysis of UCN polarization can be used in the new EDM spectrometer

  19. Position detector

    International Nuclear Information System (INIS)

    Hayakawa, Toshifumi.

    1985-01-01

    Purpose: To enable to detect the position of an moving object in a control rod position detector, stably in a digital manner at a high accuracy and free from the undesired effects of circumstantial conditions such as the reactor temperature. Constitution: Coils connected in parallel with each other are disposed along the passage of a moving object and variable resistors and relays are connected in series with each of the coils respectively. Light emitting diodes is connected in series with the contacts of the respective relays. The resistance value of the variable resistors are adjusted depending on the changes in the circumstantial conditions and temperature distribution upon carrying out the positional detection. When the object is inserted into a coils, the relevant relay is deenergized, by which the relay contacts are closed to light up the diode. In the same manner, as the object is successively inserted into the coils, the diodes are lighted-up successively thereby enabling highly accurate and stable positional detection in a digital manner, free from the undesired effects of the circumstantial conditions. (Horiuchi, T.)

  20. MUON DETECTOR

    CERN Multimedia

    F. Gasparini

    DT As announced in the previous Bulletin MU DT completed the installation of the vertical chambers of barrel wheels 0, +1 and +2. 242 DT and RPC stations are now installed in the negative barrel wheels. The missing 8 (4 in YB-1 and 4 in YB-2) chambers can be installed only after the lowering of the two wheels into the UX cavern, which is planned for the last quarter of the year. Cabling on the surface of the negative wheels was finished in May after some difficulties with RPC cables. The next step was to begin the final commissioning of the wheels with the final trigger and readout electronics. Priority was giv¬en to YB0 in order to check everything before the chambers were covered by cables and services of the inner detectors. Commissioning is not easy since it requires both activity on the central and positive wheels underground, as well as on the negative wheels still on the surface. The DT community is requested to commission the negative wheels on surface to cope with a possible lack of time a...

  1. MUON DETECTORS: RPC

    CERN Multimedia

    P. Paolucci

    2013-01-01

    During LS1, the Resistive Plate Chamber (RPC) collaboration is focusing its efforts on installation and commissioning of the fourth endcap station (RE4) and on the reparation and maintenance of the present system (1100 detectors). The 600 bakelite gaps, needed to build 200 double-gap RE4 chambers are being produced in Korea. Chamber construction and testing sites are located at CERN, in Ghent University, and at BARC (India). At present, 42 chambers have been assembled, 32 chambers have been successfully tested with cosmic rays runs and 7 Super Modules, made by two chambers, have been built at CERN by a Bulgarian/Georgian/Italian team and are now ready to be installed in the positive endcap. The 36 Super Modules needed to complete the positive endcap will be ready in September and installation is scheduled for October 2013. The Link-Board system for RE4 is under construction in Naples. Half of the system has been delivered at CERN in June. Six crates (Link-Board Boxes) and 75 boards, needed to instrument t...

  2. EFECTO DEL 1-METILCICLOPROPENO (1-MCP Y TRATAMIENTO HIDROTÉRMICO SOBRE LA FISIOLOGÍA Y CALIDAD DEL MANGO 'KEITT'

    Directory of Open Access Journals (Sweden)

    J. A. Osuna-García

    2007-01-01

    Full Text Available El objetivo del presente trabajo fue evaluar el efecto del 1-MCP (0 y 300 nl·litro-1 y diferentes niveles de tratamiento hidrotérmico (0, 52 °C por 5 min y 46 °C por 110 min sobre la fisiología y calidad de mango 'Keitt'. Se analizó velocidad de respiración, pérdida de peso, firmeza, color de pulpa, sólidos solubles totales y porcentaje de frutos enfermos. Se encontró que la efectividad del 1-MCP varió acorde al nivel de tratamiento hidrotérmico. En frutos sin hidrotérmico el 1-MCP disminuyó velocidad de respiración, no influyó en la pérdida de peso, mantuvo cuatro veces más la firmeza y retrasó el cambio de color de pulpa y el aumento de los sólidos solubles. Sin embargo, bajo tratamiento hidrotérmico por 5 min el 1-MCP incrementó velocidad de respiración, no influyó en la pérdida de peso, mantuvo dos veces más la firmeza de pulpa, retrasó el desarrollo del color de pulpa y mantuvo sin cambios los sólidos solubles. La efectividad del 1-MCP sobre firmeza y pérdida de peso fue significativamente afectada por el tratamiento hidrotérmico de 110 min, y no tuvo ningún efecto sobre el control de enfermedades, sin embargo, el tratamiento con agua caliente por 5 min redujo en más de 50 % la presencia de frutos enfermos. El 1-MCP en combinación con el tratamiento hidrotérmico de 5 min alargó en cinco días la vida de anaquel de los frutos y podría ser una alternativa viable en mercados que no requieren tratamiento hidrotérmico cuarentenario para el control de mosca de la fruta.

  3. p115 RhoGEF activates the Rac1 GTPase signaling cascade in MCP1 chemokine-induced vascular smooth muscle cell migration and proliferation.

    Science.gov (United States)

    Singh, Nikhlesh K; Janjanam, Jagadeesh; Rao, Gadiparthi N

    2017-08-25

    Although the involvement of Rho proteins in the pathogenesis of vascular diseases is well studied, little is known about the role of their upstream regulators, the Rho guanine nucleotide exchange factors (RhoGEFs). Here, we sought to identify the RhoGEFs involved in monocyte chemotactic protein 1 (MCP1)-induced vascular wall remodeling. We found that, among the RhoGEFs tested, MCP1 induced tyrosine phosphorylation of p115 RhoGEF but not of PDZ RhoGEF or leukemia-associated RhoGEF in human aortic smooth muscle cells (HASMCs). Moreover, p115 RhoGEF inhibition suppressed MCP1-induced HASMC migration and proliferation. Consistent with these observations, balloon injury (BI) induced p115 RhoGEF tyrosine phosphorylation in rat common carotid arteries, and siRNA-mediated down-regulation of its levels substantially attenuated BI-induced smooth muscle cell migration and proliferation, resulting in reduced neointima formation. Furthermore, depletion of p115 RhoGEF levels also abrogated MCP1- or BI-induced Rac1-NFATc1-cyclin D1-CDK6-PKN1-CDK4-PAK1 signaling, which, as we reported previously, is involved in vascular wall remodeling. Our findings also show that protein kinase N1 (PKN1) downstream of Rac1-cyclin D1/CDK6 and upstream of CDK4-PAK1 in the p115 RhoGEF-Rac1-NFATc1-cyclin D1-CDK6-PKN1-CDK4-PAK1 signaling axis is involved in the modulation of vascular wall remodeling. Of note, we also observed that CCR2-G i/o -Fyn signaling mediates MCP1-induced p115 RhoGEF and Rac1 GTPase activation. These findings suggest that p115 RhoGEF is critical for MCP1-induced HASMC migration and proliferation in vitro and for injury-induced neointima formation in vivo by modulating Rac1-NFATc1-cyclin D1-CDK6-PKN1-CDK4-PAK1 signaling. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

  4. Cigarette smoke-related hydroquinone dysregulates MCP-1, VEGF and PEDF expression in retinal pigment epithelium in vitro and in vivo.

    Directory of Open Access Journals (Sweden)

    Marianne Pons

    2011-02-01

    Full Text Available Age-related macular degeneration (AMD is the leading cause of legal blindness in the elderly population. Debris (termed drusen below the retinal pigment epithelium (RPE have been recognized as a risk factor for dry AMD and its progression to wet AMD, which is characterized by choroidal neovascularization (CNV. The underlying mechanism of how drusen might elicit CNV remains undefined. Cigarette smoking, oxidative damage to the RPE and inflammation are postulated to be involved in the pathophysiology of the disease. To better understand the cellular mechanism(s linking oxidative stress and inflammation to AMD, we examined the expression of pro-inflammatory monocyte chemoattractant protein-1 (MCP-1, pro-angiogenic vascular endothelial growth factor (VEGF and anti-angiogenic pigment epithelial derived factor (PEDF in RPE from smoker patients with AMD. We also evaluated the effects of hydroquinone (HQ, a major pro-oxidant in cigarette smoke on MCP-1, VEGF and PEDF expression in cultured ARPE-19 cells and RPE/choroids from C57BL/6 mice.MCP-1, VEGF and PEDF expression was examined by real-time PCR, Western blot, and ELISA. Low levels of MCP-1 protein were detected in RPE from AMD smoker patients relative to controls. Both MCP-1 mRNA and protein were downregulated in ARPE-19 cells and RPE/choroids from C57BL/6 mice after 5 days and 3 weeks of exposure to HQ-induced oxidative injury. VEGF protein expression was increased and PEDF protein expression was decreased in RPE from smoker patients with AMD versus controls resulting in increased VEGF/PEDF ratio. Treatment with HQ for 5 days and 3 weeks increased the VEGF/PEDF ratio in vitro and in vivo.We propose that impaired RPE-derived MCP-1-mediated scavenging macrophages recruitment and phagocytosis might lead to incomplete clearance of proinflammatory debris and infiltration of proangiogenic macrophages which along with increased VEGF/PEDF ratio favoring angiogenesis might promote drusen accumulation and

  5. A case-control association study between Obsessive-Compulsive Disorder (OCD and the MCP-1 -2518G/A polymorphism in a Chinese sample Estudo de associação de casos-controle entre Transtorno Obsessivo-Compulsivo (TOC e polimorfismo MCP-1 -2518G/A em uma coorte chinesa

    Directory of Open Access Journals (Sweden)

    Xinhua Zhang

    2012-12-01

    Full Text Available OBJECTIVE: To investigate the association between Obsessive-Compulsive Disorder (OCD and a functional polymorphism of MCP-1 in the Chinese Han population. METHOD: We genotyped and performed a case-control association analysis of the MCP-1 -2518G/A polymorphism in 200 OCD patients and 294 healthy control subjects. RESULTS: There was no significant difference in MCP-1 -2518G/A genotypic and allelic frequencies between OCD cases and controls (x² = 1.123, df = 2, P = 0.57 by genotype; x² = 0.802, df = 1, P = 0.37 by allele. CONCLUSIONS: Our results indicated that MCP-1 -2518G/A may not play a major role in the genetic predisposition of the Chinese Han population to OCD. However, further studies using a larger number of subjects are required to obtain a clear conclusion.OBJETIVO: Investigar a relação entre Transtorno Obsessivo-Compusilvo (TOC e um polimorfismo funcional de MCP-1 na população chinesa de etnia Han. MÉTODOS: Determinamos os genótipos e realizamos uma análise de associações de casos-controle de polimorfismo MCP-1 -2518G/A em 200 indivíduos com TOC e 294 indivíduos saudáveis (controle. RESULTADOS: Não houve diferença significativa no genótipo MCP-1 -2518G/A e nas frequências alélicas entre casos de TOC e controles (x² = 1,123, df = 2, P = 0,57 por genotipo; x² = 0,802, df = 1, P = 0,37 por alelo. CONCLUSÕES: Nossos resultados indicaram que MCP-1 -2518G/A pode não ter grande participação na predisposição genética da etnia Han no que diz respeito ao TOC. Contudo, novos estudos com um maior número de indivíduos são necessários para uma conclusão mais clara.

  6. Detector simulation needs for detector designers

    International Nuclear Information System (INIS)

    Hanson, G.G.

    1987-11-01

    Computer simulation of the components of SSC detectors and of the complete detectors will be very important for the designs of the detectors. The ratio of events from interesting physics to events from background processes is very low, so detailed understanding of detector response to the backgrounds is needed. Any large detector for the SSC will be very complex and expensive and every effort must be made to design detectors which will have excellent performance and will not have to undergo major rebuilding. Some areas in which computer simulation is particularly needed are pattern recognition in tracking detectors and development of shower simulation code which can be trusted as an aid in the design and optimization of calorimeters, including their electron identification performance. Existing codes require too much computer time to be practical and need to be compared with test beam data at energies of several hundred GeV. Computer simulation of the processing of the data, including electronics response to the signals from the detector components, processing of the data by microprocessors on the detector, the trigger, and data acquisition will be required. In this report we discuss the detector simulation needs for detector designers

  7. Large area two dimensional position sensitive detectors

    International Nuclear Information System (INIS)

    Sann, H.; Olmi, A.; Lynen, U.; Stelzer, H.; Gobbi, A.; Bock, R.

    1979-02-01

    After an introduction, a position-sensitive ionization chamber, a parallel-plate detector, and a multiwire position-sensitive chamber are described. Then the data acquisition and analysis methods are considered. Furthermore, the experimental methods for a multi-parameter experiment are described. Finally, the measurement of gamma-ray and neutron multiplicities and sequential fission is considered, and the results are presented. (HSI) [de

  8. Plate Full of Color

    Centers for Disease Control (CDC) Podcasts

    The Eagle Books are a series of four books that are brought to life by wise animal characters - Mr. Eagle, Miss Rabbit, and Coyote - who engage Rain That Dances and his young friends in the joy of physical activity, eating healthy foods, and learning from their elders about health and diabetes prevention. Plate Full of Color teaches the value of eating a variety of colorful and healthy foods.

  9. On aging problem of glass Resistive Plate Chambers

    International Nuclear Information System (INIS)

    Bhide, S.S.; Datar, V.M.; Kalmani, S.D.; Mondal, N.K.; Pant, L.M.; Satyanarayana, B.; Shinde, R.R.

    2006-01-01

    Resistive Plate Chambers (RPCs) were chosen to be the active elements for a 50kton neutrino detector, which is proposed to be built by the India-based Neutrino Observatory (INO) collaboration. As part of the detector R and D programme, we have built a large number of prototype RPCs and studied their characteristics. While, the results obtained by us are in agreement with those reported in the literature, the RPCs were observed to suffer severe damage when operated continuously for a few months. We summarise here our studies on this problem

  10. Aging phenomena in gaseous detectors - perspectives from the 2001 workshop

    CERN Document Server

    Hohlmann, M; Tesch, N; Titov, M

    2002-01-01

    High-Energy Physics experiments are currently entering a new era which requires the operation of gaseous particle detectors at unprecedented high rates and integrated particle fluxes. Full functionality of such detectors over the lifetime of an experiment in a harsh radiation environment is of prime concern. New classes of gaseous detectors such as large-scale straw-type detectors, Micro-pattern Gas Detectors, and resistive plate chambers--each with their own specific aging characteristics--have evolved since the first workshop on wire chamber aging was held at LBL, Berkeley in 1986. The 2001 workshop provided a forum to review the progress since 1986 in understanding aging effects and to exchange recent experiences. A summary of the main results reported at the 2001 workshop is presented providing a systematic review of aging effects in state-of-the-art detectors.

  11. Status of the digital pixel array detector for protein crystallography

    CERN Document Server

    Datte, P; Beuville, E; Endres, N; Druillole, F; Luo, L; Millaud, J E; Xuong, N H

    1999-01-01

    A two-dimensional photon counting digital pixel array detector is being designed for static and time resolved protein crystallography. The room temperature detector will significantly enhance monochromatic and polychromatic protein crystallographic through-put data rates by more than three orders of magnitude. The detector has an almost infinite photon counting dynamic range and exhibits superior spatial resolution when compared to present crystallographic phosphor imaging plates or phosphor coupled CCD detectors. The detector is a high resistivity N-type Si with a pixel pitch of 150x150 mu m, and a thickness of 300 mu m, and is bump bonded to an application specific integrated circuit. The event driven readout of the detector is based on the column architecture and allows an independent pixel hit rate above 1 million photons/s/pixel. The device provides energy discrimination and sparse data readout which yields minimal dead-time. This type of architecture allows a continuous (frameless) data acquisition, a f...

  12. Effect of plate shapes in orifice plate type flowmeters

    International Nuclear Information System (INIS)

    Moeller, S.V.

    1984-01-01

    The study of unusual plate shapes in orifice plate type flowmeters is presented, with a view to providing data for the substitution of the plate with one centered circular orifice in those applications where its use is not possible. For this purpose, six pairs of plates with different forms, with and without chamfered edges, were made and tested in a closed water loop. Results show that, generally, the use of chamfers improves the results and, in the case of perforated and slotlike orificed plates, the narrow-ness of the fluid passage tends to make unnecessary its use. (Author) [pt

  13. The GRANDE detector

    International Nuclear Information System (INIS)

    Adams, A.; Bond, R.; Coleman, L.; Rollefson, A.; Wold, D.; Bratton, C.B.; Gurr, H.; Kropp, W.; Nelson, M.; Price, L.R.; Reines, F.; Schultz, J.; Sobel, H.; Svoboda, R.; Yodh, G.; Burnett, T.; Chaloupka, V.; Wilkes, R.J.; Cherry, M.; Ellison, S.B.; Guzik, T.G.; Wefel, J.; Gaidos, J.; Loeffler, F.; Sembroski, G.; Wilson, C.; Goodman, J.; Haines, T.J.; Kielczewska, D.; Lane, C.; Steinberg, R.; Lieber, M.; Nagle, D.; Potter, M.; Tripp, R.

    1990-01-01

    In this paper we present a detector facility which meets the requirements outlined above for a next-generation instrument. GRANDE (Gamma Ray and Neutrino DEtector) is an imaging, water Cerenkov detector, which combines in one facility an extensive air shower array and a high-energy neutrino detector. (orig.)

  14. Spiral silicon drift detectors

    International Nuclear Information System (INIS)

    Rehak, P.; Gatti, E.; Longoni, A.; Sampietro, M.; Holl, P.; Lutz, G.; Kemmer, J.; Prechtel, U.; Ziemann, T.

    1988-01-01

    An advanced large area silicon photodiode (and x-ray detector), called Spiral Drift Detector, was designed, produced and tested. The Spiral Detector belongs to the family of silicon drift detectors and is an improvement of the well known Cylindrical Drift Detector. In both detectors, signal electrons created in silicon by fast charged particles or photons are drifting toward a practically point-like collection anode. The capacitance of the anode is therefore kept at the minimum (0.1pF). The concentric rings of the cylindrical detector are replaced by a continuous spiral in the new detector. The spiral geometry detector design leads to a decrease of the detector leakage current. In the spiral detector all electrons generated at the silicon-silicon oxide interface are collected on a guard sink rather than contributing to the detector leakage current. The decrease of the leakage current reduces the parallel noise of the detector. This decrease of the leakage current and the very small capacities of the detector anode with a capacitively matched preamplifier may improve the energy resolution of Spiral Drift Detectors operating at room temperature down to about 50 electrons rms. This resolution is in the range attainable at present only by cooled semiconductor detectors. 5 refs., 10 figs

  15. submitter The TORCH detector R&D: Status and perspectives

    CERN Document Server

    Gys, T; Castillo García, L; Cussans, D; Föhl, K; Forty, R; Frei, C; Gao, R; Harnew, N; Piedigrossi, D; Rademacker, J; Ros García, A; van Dijk, M

    2017-01-01

    TORCH (Timing Of internally Reflected CHerenkov photons) is a time-of-flight detector for particle identification at low momentum. It has been originally proposed for the LHCb experiment upgrade. TORCH is using plates of quartz radiator in a modular design. A fraction of the Cherenkov photons produced by charged particles passing through this radiator propagate by total internal reflection, they emerge at the edges and are subsequently focused onto fast, position-sensitive single-photon detectors. The recorded position and arrival time of the photons are used to precisely reconstruct their trajectory and propagation time in the quartz. The on-going R&D; programme aims at demonstrating the TORCH basic concept through the realization of a full detector module and has been organized on the following main development lines: micro-channel plate photon detectors featuring the required granularity and lifetime, dedicated fast front-end electronics preserving the picosecond timing information provided by single p...

  16. Plate removal following orthognathic surgery.

    Science.gov (United States)

    Little, Mhairi; Langford, Richard Julian; Bhanji, Adam; Farr, David

    2015-11-01

    The objectives of this study are to determine the removal rates of orthognathic plates used during orthognathic surgery at James Cook University Hospital and describe the reasons for plate removal. 202 consecutive orthognathic cases were identified between July 2004 and July 2012. Demographics and procedure details were collected for these patients. Patients from this group who returned to theatre for plate removal between July 2004 and November 2012 were identified and their notes were analysed for data including reason for plate removal, age, smoking status, sex and time to plate removal. 3.2% of plates were removed with proportionally more plates removed from the mandible than the maxilla. 10.4% of patients required removal of one or more plate. Most plates were removed within the first post-operative year. The commonest reasons for plate removal were plate exposure and infection. The plate removal rates in our study are comparable to those seen in the literature. Copyright © 2015 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

  17. Plate Tearing by a Cone

    DEFF Research Database (Denmark)

    Simonsen, Bo Cerup

    1997-01-01

    The present paper is concerned with steady-state plate tearing by a cone. This is a scenario where a cone is forced through a ductile metal plate with a constant lateral tip penetration in a motion in the plane of the plate. The considered process could be an idealisaton of the damage, which...... as for the out-of-plane reaction force....

  18. Normal and abnormal growth plate

    International Nuclear Information System (INIS)

    Kumar, R.; Madewell, J.E.; Swischuk, L.E.

    1987-01-01

    Skeletal growth is a dynamic process. A knowledge of the structure and function of the normal growth plate is essential in order to understand the pathophysiology of abnormal skeletal growth in various diseases. In this well-illustrated article, the authors provide a radiographic classification of abnormal growth plates and discuss mechanisms that lead to growth plate abnormalities

  19. Response of multi-strip multi-gap resistive plate chamber using pulsed electron beam

    International Nuclear Information System (INIS)

    Datta Pramanik, U.; Chakraborty, S.; Rahaman, A.; Ray, J.; Chatterjee, S.; Bemmerer, D.; Elekes, Z.; Kempe, M.; Sobiella, M.; Stach, D.; Wagner, A.; Yakorev, D.; Leifels, Y.; Simon, H.

    2011-01-01

    A prototype of Multi-strip Multi-gap Resistive Plate Chamber (MMRPC) with active area 40 cm x 20 cm has been developed at SINP, Kolkata. Electron response of the developed detector was studied using the electron linac ELBE at Forschungszentrum Dresden-Rossendorf. The development of this detector started with the aim of developing a neutron detector but this ultrafast timing detector can be used efficiently for the purpose of medical imaging, security purpose and detection of minimum ionising particle. In this article detailed analysis of electron response to our developed MMRPC will be presented

  20. Development and characterisation of a visible light photon counting imaging detector system

    CERN Document Server

    Barnstedt, J

    2002-01-01

    We report on the development of a visible light photon counting imaging detector system. The detector concept is based on standard 25 mm diameter microchannel plate image intensifiers made by Proxitronic in Bensheim (Germany). Modifications applied to these image intensifiers are the use of three microchannel plates instead of two and a high resistance ceramics plate used instead of the standard phosphor output screen. A wedge and strip anode mounted directly behind the high resistance ceramics plate was used as a read out device. This wedge and strip anode picks up the image charge of electron clouds emerging from the microchannel plates. The charge pulses are fed into four charge amplifiers and subsequently into a digital position decoding electronics, achieving a position resolution of up to 1024x1024 pixels. Mounting the anode outside the detector tube is a new approach and has the great advantage of avoiding electrical feedthroughs from the anode so that the standard image intensifier fabrication process...

  1. Solid state detector design

    International Nuclear Information System (INIS)

    Gunarwan Prayitno; Ahmad Rifai

    2010-01-01

    Much has been charged particle detector radiation detector made by the industry, especially those engaged in the development of detection equipment and components. The development and further research will be made solid state detector with silicon material. To be able to detect charged particles (radiation), required the processing of silicon material into the detector material. The method used to make silicon detector material is a lithium evaporations. Having formed an intrinsic region contactor installation process, and with testing. (author)

  2. A fast neutron detector with IP by track measurement

    International Nuclear Information System (INIS)

    Miao Zhengqiang; Yang Jun; Zhang Qiang; Zhao Xiangfeng; Wang Daohua

    2004-01-01

    Imaging Plate(IP) is very sensitive to electric particles, especially to heavy ions. As we know, the recoiling protons are produced while fast neutrons scattered in light material containing hydrogen. When the recoiling proton enters in the sensitive layer of IP, a track will be recorded by IP. In this paper, a fast neutron detector based on IP and (n, p) reaction is described in detail, the detector's efficiency is studied also. (authors)

  3. Influence of promoting blood circulation to remove blood stasis combined with laparoscopy on serum MCP-1, RANTES, oxidative stress and hormones in infertile patients with endometriosis

    Directory of Open Access Journals (Sweden)

    Xiao-Sha Zhang

    2017-11-01

    Full Text Available Objective: To observe the influence of promoting blood circulation to remove blood stasis combined with laparoscopy on serum MCP-1, RANTES, oxidative stress and hormones in infertile patients with endometriosis. Methods: A total of 60 infertile patients with endometriosis were randomly divided into observation group (30 cases and control group (30 cases. Observation group: promoting blood circulation to remove blood stasis combined with laparoscopy; control group: patients were treated only by laparoscopy. Recording and comparing the levels of MCP-1, RANTES, oxidative stress and hormones before and after treatment. Results: (1 Before treatment, there was no statistically significant difference in the serum MCP-1, RANTES, AOPP, MDA, SOD, levels between the two groups. After treatment, compared with the same group before treatment, the serum RANTES, AOPP, MDA levels of the two groups were significantly lower, the serum SOD level of the two groups were significantly higher, and those levels of observation group were significantly better than the control group, there was significant difference between the two groups. (2 Before treatment, there was no statistically significant difference in the serum FSH, LH, E2, P, PRL levels between the two groups. After treatment, compared with the same group before treatment, the serum FSH, LH, P, PRL levels of the two groups were significantly higher, the serum E2 level of the two groups were significantly lower, and those levels of observation group were significantly better than the control group, there was significant difference between the two groups. Conclusion: Promoting blood circulation to remove blood stasis combined with laparoscopy for infertile patients with endometriosis can reduce the levels of serum MCP-1, RANTES, oxidative stress, hormones and be beneficial to protect their uterine function.

  4. The host response to the probiotic Escherichia coli strain Nissle 1917: Specific up-regulation of the proinflammatory chemokine MCP-1

    Directory of Open Access Journals (Sweden)

    Ukena Sya N

    2005-12-01

    Full Text Available Abstract Background The use of live microorganisms to influence positively the course of intestinal disorders such as infectious diarrhea or chronic inflammatory conditions has recently gained increasing interest as a therapeutic alternative. In vitro and in vivo investigations have demonstrated that probiotic-host eukaryotic cell interactions evoke a large number of responses potentially responsible for the effects of probiotics. The aim of this study was to improve our understanding of the E. coli Nissle 1917-host interaction by analyzing the gene expression pattern initiated by this probiotic in human intestinal epithelial cells. Methods Gene expression profiles of Caco-2 cells treated with E. coli Nissle 1917 were analyzed with microarrays. A second human intestinal cell line and also pieces of small intestine from BALB/c mice were used to confirm regulatory data of selected genes by real-time RT-PCR and cytometric bead array (CBA to detect secretion of corresponding proteins. Results Whole genome expression analysis revealed 126 genes specifically regulated after treatment of confluent Caco-2 cells with E. coli Nissle 1917. Among others, expression of genes encoding the proinflammatory molecules monocyte chemoattractant protein-1 ligand 2 (MCP-1, macrophage inflammatory protein-2 alpha (MIP-2α and macrophage inflammatory protein-2 beta (MIP-2β was increased up to 10 fold. Caco-2 cells cocultured with E. coli Nissle 1917 also secreted high amounts of MCP-1 protein. Elevated levels of MCP-1 and MIP-2α mRNA could be confirmed with Lovo cells. MCP-1 gene expression was also up-regulated in mouse intestinal tissue. Conclusion Thus, probiotic E. coli Nissle 1917 specifically upregulates expression of proinflammatory genes and proteins in human and mouse intestinal epithelial cells.

  5. Analysis of the temporal expression of chemokines and chemokine receptors during experimental granulomatous inflammation: role and expression of MIP-1α and MCP-1

    Science.gov (United States)

    Carollo, Maria; Hogaboam, Cory M; Kunkel, Stephen L; Delaney, Stephen; Christie, Mark I; Perretti, Mauro

    2001-01-01

    Chemokine expression and function was monitored in an experimental model of granulomatous tissue formation after injection of croton oil in complete Freund's adjuvant (CO/CFA) into mouse dorsal air-pouches up to 28 days. In the first week, mast cell degranulation and leukocyte influx (mononuclear cell, MNC, and polymorphonuclear cell, PMN) were associated with CXCR2, KC and macrophage inflammatory protein (MIP)-2 mRNA expression, as determined by TaqMan® reverse transcriptase-polymerase chain reaction. KC (∼400 pg mg protein−1, n=12) and MIP-2 (∼800 pg mg protein−1, n=12) proteins peaked at day 7, together with myeloperoxidase (MPO) activity. Highest MIP-1α (>1 ng mg protein−1, n=12) levels were measured at day 3. After day 7, a gradual increase in CCR2 and CCR5 mRNA, monocyte chemoattractant protein (MCP)-1 mRNA and protein expression was measured. MCP-1 protein peaked at day 21 (∼150 pg mg protein−1, n=12) and was predominantly expressed by mast cells. A gradual increase in N-acetyl-β-D-glucosaminidase (NAG) activity (maximal at 28 days) was also measured. An antiserum against MIP-1α did not modify the inflammatory response measured at day 7 (except for a 50% reduction in MIP-1α levels), but provoked a significant increase in MPO, NAG and MCP-1 levels as measured at day 21 (n=6, Pvalues (n=8, P<0.05). In conclusion, we have shown that CO/CFA initiates a complex inflammatory reaction in which initial expression of MIP-1α serves a protective role whereas delayed expression of MCP-1 seems to have a genuine pro-inflammatory role. PMID:11704636

  6. The suppression of destructive sparks in parallel plate proportional counters

    Energy Technology Data Exchange (ETDEWEB)

    Cockshott, R.A.; Mason, I.M.

    1984-02-01

    The authors find that high energy background events produce localised sparks in parallel plate counters when operated in the proportional mode. These sparks increase dead-time and lead to degradation ranging from electrode damage to spurious pulsing and continuous breakdown. The problem is particularly serious in low energy photon detectors for X-ray astronomy which are required to have lifetimes of several years in the high radiation environment of space. For the parallel plate imaging detector developed for the European X-ray Observatory Satellite (EXOSAT) they investigate quantitatively the spark thresholds, spark rates and degradation processes. They discuss the spark mechanism, pointing out differences from the situation in spark chambers and counters. They show that the time profile of the sparks allows them to devise a spark suppression system which reduces the degradation rate by a factor of ''200.

  7. Study of uranium plating measurement

    International Nuclear Information System (INIS)

    Lin Jufang; Wen Zhongwei; Wang Mei; Wang Dalun; Liu Rong; Jiang Li; Lu Xinxin

    2007-06-01

    In neutron physics experiments, the measurement for plate-thickness of uranium can directly affect uncertainties of experiment results. To measure the plate-thickness of transform target (enriched uranium plating and depleted uranium plating), the back to back ionization chamber, small solid angle device and Au-Si surface barrier semi-conductor, were used in the experiment study. Also, the uncertainties in the experiment were analyzed. Because the inhomo-geneous of uranium lay of plate can quantitively affect the result, the homogeneity of uranium lay is checked, the experiment result reflects the homogeneity of uranium lay is good. (authors)

  8. Folic Acid Supplementation Delays Atherosclerotic Lesion Development by Modulating MCP1 and VEGF DNA Methylation Levels In Vivo and In Vitro

    Science.gov (United States)

    Cui, Shanshan; Li, Wen; Lv, Xin; Wang, Pengyan; Gao, Yuxia; Huang, Guowei

    2017-01-01

    The pathogenesis of atherosclerosis has been partly acknowledged to result from aberrant epigenetic mechanisms. Accordingly, low folate levels are considered to be a contributing factor to promoting vascular disease because of deregulation of DNA methylation. We hypothesized that increasing the levels of folic acid may act via an epigenetic gene silencing mechanism to ameliorate atherosclerosis. Here, we investigated the atheroprotective effects of folic acid and the resultant methylation status in high-fat diet-fed ApoE knockout mice and in oxidized low-density lipoprotein-treated human umbilical vein endothelial cells. We analyzed atherosclerotic lesion histology, folate concentration, homocysteine concentration, S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH), and DNA methyltransferase activity, as well as monocyte chemotactic protein-1 (MCP1) and vascular endothelial growth factor (VEGF) expression and promoter methylation. Folic acid reduced atherosclerotic lesion size in ApoE knockout mice. The underlying folic acid protective mechanism appears to operate through regulating the normal homocysteine state, upregulating the SAM: SAH ratio, elevating DNA methyltransferase activity and expression, altering MCP1 and VEGF promoter methylation, and inhibiting MCP1 and VEGF expression. We conclude that folic acid supplementation effectively prevented atherosclerosis by modifying DNA methylation through the methionine cycle, improving DNA methyltransferase activity and expression, and thus changing the expression of atherosclerosis-related genes. PMID:28475147

  9. Rhizoma coptidis Inhibits LPS-Induced MCP-1/CCL2 Production in Murine Macrophages via an AP-1 and NFB-Dependent Pathway

    Directory of Open Access Journals (Sweden)

    Andrew Remppis

    2010-01-01

    Full Text Available Introduction. The Chinese extract Rhizoma coptidis is well known for its anti-inflammatory, antioxidative, antiviral, and antimicrobial activity. The exact mechanisms of action are not fully understood. Methods. We examined the effect of the extract and its main compound, berberine, on LPS-induced inflammatory activity in a murine macrophage cell line. RAW 264.7 cells were stimulated with LPS and incubated with either Rhizoma coptidis extract or berberine. Activation of AP-1 and NFB was analyzed in nuclear extracts, secretion of MCP-1/CCL2 was measured in supernatants. Results. Incubation with Rhizoma coptidis and berberine strongly inhibited LPS-induced monocyte chemoattractant protein (MCP-1 production in RAW cells. Activation of the transcription factors AP-1 and NFB was inhibited by Rhizoma coptidis in a dose- and time-dependent fashion. Conclusions. Rhizoma coptidis extract inhibits LPS-induced MCP-1/CCL2 production in vitro via an AP-1 and NFB-dependent pathway. Anti-inflammatory action of the extract is mediated mainly by its alkaloid compound berberine.

  10. Rhizoma Coptidis Inhibits LPS-Induced MCP-1/CCL2 Production in Murine Macrophages via an AP-1 and NFκB-Dependent Pathway

    Science.gov (United States)

    Remppis, Andrew; Bea, Florian; Greten, Henry Johannes; Buttler, Annette; Wang, Hongjie; Zhou, Qianxing; Preusch, Michael R.; Enk, Ronny; Ehehalt, Robert; Katus, Hugo; Blessing, Erwin

    2010-01-01

    Introduction. The Chinese extract Rhizoma coptidis is well known for its anti-inflammatory, antioxidative, antiviral, and antimicrobial activity. The exact mechanisms of action are not fully understood. Methods. We examined the effect of the extract and its main compound, berberine, on LPS-induced inflammatory activity in a murine macrophage cell line. RAW 264.7 cells were stimulated with LPS and incubated with either Rhizoma coptidis extract or berberine. Activation of AP-1 and NFκB was analyzed in nuclear extracts, secretion of MCP-1/CCL2 was measured in supernatants. Results. Incubation with Rhizoma coptidis and berberine strongly inhibited LPS-induced monocyte chemoattractant protein (MCP)-1 production in RAW cells. Activation of the transcription factors AP-1 and NFκB was inhibited by Rhizoma coptidis in a dose- and time-dependent fashion. Conclusions. Rhizoma coptidis extract inhibits LPS-induced MCP-1/CCL2 production in vitro via an AP-1 and NFκB-dependent pathway. Anti-inflammatory action of the extract is mediated mainly by its alkaloid compound berberine. PMID:20652055

  11. Fuel cell end plate structure

    Science.gov (United States)

    Guthrie, Robin J.; Katz, Murray; Schroll, Craig R.

    1991-04-23

    The end plates (16) of a fuel cell stack (12) are formed of a thin membrane. Pressure plates (20) exert compressive load through insulation layers (22, 26) to the membrane. Electrical contact between the end plates (16) and electrodes (50, 58) is maintained without deleterious making and breaking of electrical contacts during thermal transients. The thin end plate (16) under compressive load will not distort with a temperature difference across its thickness. Pressure plate (20) experiences a low thermal transient because it is insulated from the cell. The impact on the end plate of any slight deflection created in the pressure plate by temperature difference is minimized by the resilient pressure pad, in the form of insulation, therebetween.

  12. Compound Semiconductor Radiation Detector

    International Nuclear Information System (INIS)

    Kim, Y. K.; Park, S. H.; Lee, W. G.; Ha, J. H.

    2005-01-01

    In 1945, Van Heerden measured α, β and γ radiations with the cooled AgCl crystal. It was the first radiation measurement using the compound semiconductor detector. Since then the compound semiconductor has been extensively studied as radiation detector. Generally the radiation detector can be divided into the gas detector, the scintillator and the semiconductor detector. The semiconductor detector has good points comparing to other radiation detectors. Since the density of the semiconductor detector is higher than that of the gas detector, the semiconductor detector can be made with the compact size to measure the high energy radiation. In the scintillator, the radiation is measured with the two-step process. That is, the radiation is converted into the photons, which are changed into electrons by a photo-detector, inside the scintillator. However in the semiconductor radiation detector, the radiation is measured only with the one-step process. The electron-hole pairs are generated from the radiation interaction inside the semiconductor detector, and these electrons and charged ions are directly collected to get the signal. The energy resolution of the semiconductor detector is generally better than that of the scintillator. At present, the commonly used semiconductors as the radiation detector are Si and Ge. However, these semiconductor detectors have weak points. That is, one needs thick material to measure the high energy radiation because of the relatively low atomic number of the composite material. In Ge case, the dark current of the detector is large at room temperature because of the small band-gap energy. Recently the compound semiconductor detectors have been extensively studied to overcome these problems. In this paper, we will briefly summarize the recent research topics about the compound semiconductor detector. We will introduce the research activities of our group, too

  13. [Conventional plate osteosynthesis].

    Science.gov (United States)

    Klaue, K

    2010-02-01

    Consolidation of bone is an essential clinical problem when treating fractures, fixing osteotomies and fusing joints. In most cases, the means of fixation are plates and screws. The goal is functional postoperative therapy by moving the adjacent joints and thus avoiding the deleterious disadvantages of long-lasting articular immobilization. Pre-operative planning, surgical approach, a good understanding of the precise mechanics of the structure and the biological answer for the various tissues are prerequisites of successful osteosynthesis. The choice of implants and the application of their versatility, as well as their adaptation to individual cases are the key to good results.

  14. Plate Full of Color

    Centers for Disease Control (CDC) Podcasts

    2008-08-04

    The Eagle Books are a series of four books that are brought to life by wise animal characters - Mr. Eagle, Miss Rabbit, and Coyote - who engage Rain That Dances and his young friends in the joy of physical activity, eating healthy foods, and learning from their elders about health and diabetes prevention. Plate Full of Color teaches the value of eating a variety of colorful and healthy foods.  Created: 8/4/2008 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP).   Date Released: 8/5/2008.

  15. Manufacturing process for electrodes for ionizing radiation detectors

    International Nuclear Information System (INIS)

    Tirelli, M.G.; Hecquet, R.

    1987-01-01

    A manufacturing proces for electrodes for ionizing radiation detectors, particularly electrodes for X-ray multidetectors, is proposed. It consists of electrodepositing at least one layer of an electrically conducting material on at least one side of a relatively flat plate. A ductile material is used to form the conducting layer. The assembly formed by the plate covered by the ductile conducting material is subjected to pressing to crush the ductile conducting material at least in the zones where the assembly formed by the plate and the covering material has a total thickness superior to a constant thickness desired for the electrode [fr

  16. Effects of postharvest application of 1-MCP and postcutting dip treatment on the quality and nutritional properties of fresh-cut kiwifruit.

    Science.gov (United States)

    Antunes, Maria D C; Dandlen, Susana; Cavaco, Ana M; Miguel, Graça

    2010-05-26

    Consumption of minimally processed fruit and vegetables has increased significantly in the past few years due to the consumers' life style. The aim of this study was to evaluate the effect of treatment with ascorbic acid or calcium chloride on the quality parameters of fresh-cut kiwifruit prepared from fruit previously stored for 3 months, either treated or not treated with 1-methylcyclopropene (1-MCP) before storage. Harvested fruit were treated with 1 microL L(-1) 1-MCP for 20 h at room temperature ( approximately 20 degrees C) (MCP) or had no treatment (C) and were then stored at 0 degrees C. After 3 months, fruit were removed from storage, peeled, and cut longitudinally in quarters, dipped in 2% ascorbic acid (Asc), 2% calcium chloride (Ca), or just water (cont), and kept at 2 degrees C for 8 days. Measurements of firmness, soluble solids content (SSC) ( degrees Brix), color (CIE L*, a*, b*), electrolyte leakage, sugars, organic acids, total phenolics, and antioxidant activity (DPPH and ABTS) were performed at 0, 4, and 8 days. A taste panel was performed on the seventh shelf life day. It was shown that whole MCP-treated kiwifruit kept better than the control through the 3 months storage, this effect being lost through the fresh-cut shelf life period. Furthermore, the postcut dip on 2% CaCl(2) was effective on delaying softening and browning of fresh-cut kiwifruit, which were also the fruit preferred by panelists. Both ascorbic acid and CaCl(2) were effective on preserving or improving nutritional properties (phenolics, ascorbic acid, DPPH, and ABTS) mainly in the first 4 days of shelf life. The CaCl(2) had a further beneficial effect until 8 shelf life days. It is suggested that CaCl(2) is better in keeping overall quality through 8 days of shelf life at 2 degrees C in fresh-cut kiwifruit followed by Asc, and 1-MCP has negligible effect in the conditions of this experiment.

  17. Preservação dos atributos físicos de frutos de atemoia cv. Gefner com o uso de 1-MCP e atmosfera modificad

    Directory of Open Access Journals (Sweden)

    Gláucia Michelle Cosme Silva

    2014-12-01

    Full Text Available O interesse comercial pela atemoia vem aumentando cada vez mais no Brasil. O aumento da atividade respiratória, acompanhado por modificações rápidas na composição física dos frutos podem inviabilizar sua distribuição a mercados distantes. Neste contexto, objetivou-se com o presente trabalho avaliar os atributos físicos em frutos de atemoia tratados com 1-metilciclopropeno (1-MCP e atmosfera modificada associados à refrigeração. O experimento foi instalado em delineamento experimental inteiramente casualizado, em esquema fatorial 4x5, sendo quatro concentrações de 1-MCP (0; 200; 400 e 600 ŋL L-¹ e cinco períodos de avaliação após a colheita, em intervalo de cinco dias, com quatro repetições e quatro frutos por unidade experimental. As atemoias foram colhidas em pomar comercial, no município de Matias Cardoso-MG, no estádio de maturação fisiológica, lavadas, sanitizadas e secas ao ar, depois tratadas com as concentrações de 1-MCP por oito horas, em temperatura ambiente. Logo após, quatro frutos foram dispostos em bandejas de poliestireno expandido. Alguns permaneceram sem membrana, enquanto outros foram embalados com membrana plástica de PEBD 16µm. As variáveis avaliadas nos frutos foram: perda de biomassa fresca, firmeza, concentração de CO2, etileno e coloração da casca. O uso da atmosfera modificada e do 1-MCP, associados ou não, foi eficiente no atraso do amadurecimento dos frutos, permitindo a conservação de sua qualidade física. Frutos tratados com 1-MCP apresentaram-se mais firmes, além da preservação da coloração, verificada através da luminosidade, cromaticidade e ângulo Hueº, que se mostraram superiores quando comparados aos frutos não tratados.

  18. An Edge-Based Macao License Plate Recognition System

    Directory of Open Access Journals (Sweden)

    Chi-Man Pun

    2011-04-01

    Full Text Available This paper presents a system to recognize Macao license plates. Sobel edge detector is employed to extract the vertical edges, and an edge composition algorithm is proposed to combine the edges into candidate plate regions. They are further examined on the existence of the character qMq by a verification algorithm. A row separation algorithm is also proposed to cater both one-row and two-row types of plates. Projection analysis and template matching methods are exploited to segment and recognize the characters. Various pre and post processing steps are proposed other than traditional implementation so as to improve the recognition accuracy. This work achieves a high recognition rate of 95%.

  19. Plating on difficult-to-plate metals: what's new

    International Nuclear Information System (INIS)

    Wiesner, H.J.

    1980-01-01

    Some of the changes since 1970 in procedures for plating on such materials as titanium, molybdenum, silicon, aluminum, and gallium arsenide are summarized. While basic procedures for plating some of these materials were developed as many as 30 to 40 years ago, changes in the end uses of the plated products have necessitated new plating processes. In some cases, vacuum techniques - such as ion bombardment, ion implantation, and vacuum metallization - have been introduced to improve the adhesion of electrodeposits. In other cases, these techniques have been used to deposit materials upon which electrodeposits are required

  20. Timing properties of a time-of-flight detector

    International Nuclear Information System (INIS)

    Nakagawa, Takahide; Yuasa-Nakagawa, Keiko.

    1989-01-01

    The time resolution of a time-of-flight (T.O.F.) detector which consists of a channel plate detector (CPD) with a central hole and a surface barrier detector (SBD) was measured. A time resolution of 80 psec fwhm was obtained for 8.78 MeV alpha particles. The influence on fast timing of the SBD of alpha particles was carefully studied. The plasma delay time and time resolution of the SBD were found to strongly depend on the electric field strength and properties of the SBD. (author)

  1. Drift Chambers detectors; Detectores de deriva

    Energy Technology Data Exchange (ETDEWEB)

    Duran, I; Martinez laso, L

    1989-07-01

    We present here a review of High Energy Physics detectors based on drift chambers. The ionization, drift diffusion, multiplication and detection principles are described. Most common drift media are analysed, and a classification of the detectors according to its geometry is done. Finally the standard read-out methods are displayed and the limits of the spatial resolution are discussed. (Author) 115 refs.

  2. Resistive Plate Chambers commissioning and performance results for 2015

    CERN Document Server

    CMS Collaboration

    2016-01-01

    The Resistive Plate Chamber (RPC) detector system at the Compact Muon Solenoid experiment at the LHC confers robustness and redundancy to the muon trigger. During the first long shutdown of the LHC (2013-2014) the CMS muon RPC system has been upgraded with 144 double-gap chambers on the forth forward stations. A total of 1056 double-gap chambers cover the pseudo-rapidity region up to 1.6. The main detector parameters are constantly and closely monitored to achieve operational stability and high quality data in the harsh conditions of the second run period of the LHC (13 TeV and 25 ns bunch spacing). Resistive Plate Chambers (RPC) performance results for 2015 with pp collisions at 13 TeV are presented. These results include the occupancy, efficiency of newly installed detectors after applying new working point, history plots for the RPC relevant variables such as: Cluster Size, Efficiency, percentage of inactive detector during operation and Rates and overall system noise. RPC variables are studied as funct...

  3. Atomic layer deposition of alternative glass microchannel plates

    Energy Technology Data Exchange (ETDEWEB)

    O' Mahony, Aileen, E-mail: aom@incomusa.com; Craven, Christopher A.; Minot, Michael J.; Popecki, Mark A.; Renaud, Joseph M.; Bennis, Daniel C.; Bond, Justin L.; Stochaj, Michael E.; Foley, Michael R.; Adams, Bernhard W. [Incom, Inc., 294 Southbridge Road, Charlton, Massachusetts 01507 (United States); Mane, Anil U.; Elam, Jeffrey W. [Argonne National Laboratory, 9700 S. Cass Ave., Argonne, Illinois 60439 (United States); Ertley, Camden; Siegmund, Oswald H. W. [Space Sciences Laboratory, University of California, 7 Gauss Way, Berkeley, California 94720 (United States)

    2016-01-15

    The technique of atomic layer deposition (ALD) has enabled the development of alternative glass microchannel plates (MCPs) with independently tunable resistive and emissive layers, resulting in excellent thickness uniformity across the large area (20 × 20 cm), high aspect ratio (60:1 L/d) glass substrates. Furthermore, the use of ALD to deposit functional layers allows the optimal substrate material to be selected, such as borosilicate glass, which has many benefits compared to the lead-oxide glass used in conventional MCPs, including increased stability and lifetime, low background noise, mechanical robustness, and larger area (at present up to 400 cm{sup 2}). Resistively stable, high gain MCPs are demonstrated due to the deposition of uniform ALD resistive and emissive layers on alternative glass microcapillary substrates. The MCP performance characteristics reported include increased stability and lifetime, low background noise (0.04 events cm{sup −2} s{sup −1}), and low gain variation (±5%)

  4. arXiv Performance of the ALICE Time-Of-Flight detector at the LHC

    CERN Document Server

    INSPIRE-00531272

    The ALICE Time-Of-Flight (TOF) detector at LHC is based on the Multigap Resistive Plate Chambers (MRPCs). The TOF performance during LHC Run 2 is here reported. Particular attention is given to the improved time resolution reached by TOF detector of $56$ ps, with the consequently improved particle identification capabilities.

  5. A position-sensitive start detector for time-of-flight measurement

    International Nuclear Information System (INIS)

    Ikezoe, Hiroshi; Shikazono, Naomoto; Isoyama, Goro.

    1978-08-01

    A position-sensitive start detector for a time-of-flight measurement is described. In this detector microchannel plates were used to obtain time and position signals simultaneously. A time resolution of 121 psec FWHM and a position resolution of 0.28 mm FWHM were obtained for α-particles from an 241 Am source. (auth.)

  6. MARTA: A high-energy cosmic-ray detector concept with high-accuracy muon measurement

    Energy Technology Data Exchange (ETDEWEB)

    Abreu, P.; et al.

    2017-12-20

    A new concept for the direct measurement of muons in air showers is presented. The concept is based on resistive plate chambers (RPCs), which can directly measure muons with very good space and time resolution. The muon detector is shielded by placing it under another detector able to absorb and measure the electromagnetic component of the showers such as a water-Cherenkov detector, commonly used in air shower arrays. The combination of the two detectors in a single, compact detector unit provides a unique measurement that opens rich possibilities in the study of air showers.

  7. Mica fission detectors

    International Nuclear Information System (INIS)

    Wong, C.; Anderson, J.D.; Hansen, L.; Lehn, A.V.; Williamson, M.A.

    1977-01-01

    The present development status of the mica fission detectors is summarized. It is concluded that the techniques have been refined and developed to a state such that the mica fission counters are a reliable and reproducible detector for fission events

  8. Barrier Infrared Detector (BIRD)

    Data.gov (United States)

    National Aeronautics and Space Administration — A recent breakthrough in MWIR detector design, has resulted in a high operating temperature (HOT) barrier infrared detector (BIRD) that is capable of spectral...

  9. Simulating detectors dead time

    International Nuclear Information System (INIS)

    Rustom, Ibrahim Farog Ibrahim

    2015-06-01

    Nuclear detectors are used in all aspects of nuclear measurements. All nuclear detectors are characterized by their dead time i.e. the time needed by a detector to recover from a previous incident. A detector dead time influences measurements taken by a detector and specially when measuring high decay rate (>) where is the detector dead time. Two models are usually used to correct for the dead time effect: the paralayzable and the non-paralayzable models. In the current work we use Monte Carlo simulation techniques to simulate radioactivity and the effect of dead time and the count rate of a detector with a dead time =5x10 - 5s assuming the non-paralayzable model. The simulation indicates that assuming a non -paralayzable model could be used to correct for decay rate measured by a detector. The reliability of the non-paralayzable model to correct the measured decay rate could be gauged using the Monte Carlo simulation. (Author)

  10. Forward tracking detectors

    Indian Academy of Sciences (India)

    Abstract. Forward tracking is an essential part of a detector at the international linear collider (ILC). The requirements for forward tracking are explained and the proposed solutions in the detector concepts are shown.

  11. Plate Tearing by a Cone

    DEFF Research Database (Denmark)

    Simonsen, Bo Cerup

    1998-01-01

    The present paper is concerned with steady-state plate tearing by a cone. This is a scenario where a cone is forced through a ductile metal plate with a constant lateral tip penetration in a motion in the plane of the plate. The considered process could be an idealisation of the damage, which...... as for the out-of-plane reaction force. (C) 1998 Elsevier Science Ltd. All rights reserved....

  12. Bipolar Plates for PEM Systems

    OpenAIRE

    Lædre, Sigrid

    2016-01-01

    Summary of thesis: The Bipolar Plate (BPP) is an important component in both Proton Exchange Membrane Fuel Cells (PEMFCs) and Proton Exchange Membrane Water Electrolyzers (PEMWEs). Bipolar plate material and processing constitutes for a large fraction of the cost and weight of a PEM cell stack. The main tasks for the bipolar plates in both systems are to separate single cell in a stack, conduct current between single cells and remove heat from active areas. In addition, the BPPs distribu...

  13. HIBP primary beam detector

    International Nuclear Information System (INIS)

    Schmidt, T.W.

    1979-01-01

    A position measuring detector was fabricated for the Heavy Ion Beam Probe. The 11 cm by 50 cm detector was a combination of 15 detector wires in one direction and 63 copper bars - .635 cm by 10 cm to measure along an orthogonal axis by means of a current divider circuit. High transmission tungsten meshes provide entrance windows and suppress secondary electrons. The detector dimensions were chosen to resolve the beam position to within one beam diameter

  14. The OSMOND detector

    Energy Technology Data Exchange (ETDEWEB)

    Bateman, J.E. [Technology Dept. Science and Technology Facilities Council, Rutherford Appleton Laboratory, Harwell Oxford, Oxfordshire, OX11 0QX (United Kingdom); Dalgliesh, R. [ISIS Dept. Science and Technology Facilities Council, Rutherford Appleton Laboratory, Harwell Oxford, Oxfordshire, OX11 0QX (United Kingdom); Duxbury, D.M., E-mail: dom.duxbury@stfc.ac.uk [Technology Dept. Science and Technology Facilities Council, Rutherford Appleton Laboratory, Harwell Oxford, Oxfordshire, OX11 0QX (United Kingdom); Helsby, W.I. [Science and Technology Facilities Council, Daresbury Laboratory, Keckwick Lane, Daresbury, Warrington WA4 4AD (United Kingdom); Holt, S.A.; Kinane, C.J. [ISIS Dept. Science and Technology Facilities Council, Rutherford Appleton Laboratory, Harwell Oxford, Oxfordshire, OX11 0QX (United Kingdom); Marsh, A.S. [Diamond Light Source LTD, Harwell Science and Innovation Campus, Diamond House, Chilton, Didcot, Oxfordshire, OX11 0DE (United Kingdom); Rhodes, N.J.; Schooneveld, E.M. [ISIS Dept. Science and Technology Facilities Council, Rutherford Appleton Laboratory, Harwell Oxford, Oxfordshire, OX11 0QX (United Kingdom); Spill, E.J.; Stephenson, R. [Technology Dept. Science and Technology Facilities Council, Rutherford Appleton Laboratory, Harwell Oxford, Oxfordshire, OX11 0QX (United Kingdom)

    2013-01-11

    The development and testing of the Off Specular MicrOstrip Neutron Detector (OSMOND) is described. Based on a microstrip gas chamber the aim of the project was to produce a high counting rate detector capable of replacing the existing rate limited scintillator detectors currently in use on the CRISP reflectometer for off specular reflectometry experiments. The detector system is described together with results of neutron beam tests carried out at the ISIS spallation neutron source.

  15. Reviewing metallic PEMFC bipolar plates

    Energy Technology Data Exchange (ETDEWEB)

    Wang, H.; Turner, J.A. [National Renewable Energy Laboratory, Golden, CO (United States)

    2010-08-15

    A bipolar plate is one of the most important components in a polymer exchange membrane fuel cell (PEMFC) stack and has multiple functions. Metallic bipolar plate candidates have advantages over composite rivals in excellent electrical and thermal conductivity, good mechanical strength, high chemical stability, very wide alloy choices, low cost and, most importantly, existing pathways for high-volume, high-speed mass production. The challenges with metallic bipolar plates are the higher contact resistance and possible corrosion products, which may contaminate the membrane electrode assembly. This review evaluates the candidate metallic and coating materials for bipolar plates and gives the perspective of the research trends. (Abstract Copyright [2010], Wiley Periodicals, Inc.)

  16. Test Method for High β Particle Emission Rate of 63Ni Source Plate

    OpenAIRE

    ZHANG Li-feng

    2015-01-01

    For the problem of measurement difficulties of β particle emission rate of Ni-63 source plate used for Ni-63 betavoltaic battery, a relative test method of scintillation current method was erected according to the measurement principle of scintillation detector.β particle emission rate of homemade Ni-63 source plate was tested by the method, and the test results were analysed and evaluated, it was initially thought that scintillation current method was a feasible way of testing β particle emi...

  17. Performance of the E771 RPC muon detector at Fermilab

    International Nuclear Information System (INIS)

    Cataldi, G.; Creti, P.; Elia, V.; Fiore, G.; Gorini, E.; Grancagnolo, F.; Panareo, M.; Pinto, C.; Antoniazzi, L.; Introzzi, G.; Lanza, A.; Liguori, G.; Torre, P.; Corti, G.

    1994-01-01

    The technique of resistive plate counters, equipped with pad readout instead of strips, has been successfully used for the first time in a high rate environment. The performance of the muon detector of E771, based on this technique, is illustrated in detail, including the dependence of the efficiency on the local rate of incident particles. (orig.)

  18. Searching for universal behaviour in superheated droplet detector ...

    Indian Academy of Sciences (India)

    induced events and γ-induced events for R114 detector has been described. ... allel plates of which one is made of a very light material which acts as a ... tron through the elastic head-on collision and that energy is considered in .... neutrons from 252Cf fission neutron source occurs at about 700 keV [18], the maximum.

  19. Segmented focal plane detector for light and heavy ions

    International Nuclear Information System (INIS)

    Wolfs, F.L.H.; Bryan, D.C.; Kurz, K.L.; Herrick, D.M.; Perera, P.A.A.; White, C.A.

    1992-01-01

    A segmented focal plane detector for an Enge split-pole spectrograph has been developed for the study of breakup reactions at very low relative energies. It consists of a 61 cm long segmented position-sensitive parallel plate avalanche counter backed by a large Bragg curve detector. A segmented plastic scintillator is mounted behind the anode of the Bragg curve detector and is used for particle identification of low-ionizing particles. The dead space between the two sections of the focal plane detector is 2.5 mm. The intrinsic position resolution of the detector is 1 mm. The intrinsic energy resolution depends on the energy of the incident ion and can be as good as 0.55%. The nuclear charge and mass resolutions are 0.3 e and 0.3 u, respectively. (orig.)

  20. Development of Micro-Pattern Gas Detectors Technologies

    CERN Multimedia

    Richer, J; Barsuk, S; Shah, M K; Catanesi, M G; Colaleo, A; Maggi, M; Loddo, F; Berardi, V; Bagliesi, M; Menon, G; Richter, R; Lahonde-hamdoun, C; Dris, M; Chechik, R; Ochi, A; Hartjes, F; Lopes, I M; Deshpande, A; Franz, A; Fiutowski, T A; Ferreira, A; Bastos de oliveira, C A; Miller, B W; Monrabal-capilla, F; Liubarsky, I; Plazas de pinzon, M C; Tsarfati, T; Voss, B J R; Carmona martinez, J M; Stocchi, A; Dinu, N; Semeniouk, I; Giebels, B; Marton, K; De leo, R; De lucia, E; Alviggi, M; Bellerive, A; Herten, L G; Zimmermann, S U; Giomataris, I; Peyaud, A; Schune, P; Delagnes, E; Delbart, A; Charles, G; Wang, W; Markou, A; Arazi, L; Cibinetto, G; Edo, Y; Neves, F F; Solovov, V; Stoll, S; Sampsonidis, D; Dabrowski, W; Mindur, B; Sauli, F; Calapez de albuquerque veloso, J F; Kahlaoui, N; Sharma, A; Zenker, K; Cebrian guajardo, S V; Luzon marco, G M; Guillaudin, O J H; Cornebise, P; Lounis, A; Bruel, P J; Laszlo, A; Mukerjee, K; Nappi, E; Nuzzo, S V; Bencivenni, G; Tessarotto, F; Levorato, S; Dixit, M S; Riallot, M; Jeanneau, F; Nizery, F G; Maltezos, S; Kyriakis, A; Lyashenko, A; Van der graaf, H; Ferreira marques, R; Alexa, C; Liyanage, N; Dehmelt, K; Hemmick, T K; Polychronakos, V; Cisbani, E; Garibaldi, F; Koperny, S Z; Das neves dias carramate, L F; Munoz-vidal, J; Gutierrez, R; Van stenis, M; Resnati, F; Lupberger, M; Desch, K K; Chefdeville, M; Vouters, G; Ranieri, A; Lami, S; Shekhtman, L; Dolgov, A; Bamberger, A; Landgraf, U; Kortner, O; Ferrero, A; Aune, S; Attie, D M; Bakas, G; Balossino, I; Tsigaridas, S; Surrow, B; Gnanvo, K A K; Feege, N M; Woody, C L; Bhattacharya, S; Capogni, M; Veenhof, R J; Tapan, I; Dangendorf, V; Monteiro bernades, C M; Castro serrato, H F; De oliveira, R; Ropelewski, L; Behnke, T; Boudry, V; Radicioni, E; Lai, A; Shemyakina, E; Giganon, A E; Titov, M; Papakrivopoulos, I; Komai, H; Van bakel, N A; Tchepel, V; Repond, J O; Li, Y; Kourkoumelis, C; Tzamarias, S; Majumdar, N; Kowalski, T; Da rocha azevedo, C D; Serra diaz cano, L; Alvarez puerta, V; Trabelsi, A; Riegler, W; Ketzer, B F; Rosemann, C G; Herrera munoz, D C; Drancourt, C; Mayet, F; Geerebaert, Y; De robertis, G; Felici, G; Scribano memoria, A; Cecchi, R; Dalla torre, S; Gregori, M; Buzulutskov, A; Schwegler, P; Sanchez nieto, F J; Colas, P M A; Gros, M; Neyret, D; Zito, M; Ferrer ribas, E; Breskin, A; Martoiu, V S; Purschke, M L; Loomba, D; Gasik, P J; Petridou, C; Kordas, K; Mukhopadhyay, S; Bucciantonio, M; Biagi, S F; Ji, X; Kanaki, K; Zavazieva, D; Capeans garrido, M D M; Schindler, H; Kaminski, J; Krautscheid, T; Lippmann, C; Arora, R; Dafni, T; Garcia irastorza, I; Puill, V; Wicek, F B; Burmistrov, L; Singh, K P; Kroha, H; Kunne, F; Alexopoulos, T; Daskalakis, G; Geralis, T; Bettoni, D; Heijhoff, K; Xiao, Z; Tzanakos, G; Leisos, A; Frullani, S; Sahin, O; Kalkan, Y; Giboni, K; Krieger, C; Breton, D R; Bhattacharyya, S; Abbrescia, M; Erriquez, O; Paticchio, V; Cardini, A; Aloisio, A; Turini, N; Bressan, A; Tikhonov, Y; Schumacher, M; Simon, F R; Nowak, S; Herlant, S; Chaus, A; Fanourakis, G; Bressler, S; Homma, Y; Timmermans, J; Fonte, P; Underwood, D G; Azmoun, B; Fassouliotis, D; Wiacek, P; Dos santos covita, D; Monteiro da silva, A L; Yahlali haddou, N; Marques ferreira dos santos, J; Domingues amaro, F

    The proposed R&D collaboration, RD51, aims at facilitating the development of advanced gas-avalanche detector technologies and associated electronic-readout systems, for applications in basic and applied research. Advances in particle physics have always been enabled by parallel advances in radiation-detector technology. Radiation detection and imaging with gas-avalanche detectors, capable of economically covering large detection volumes with a low material budget, have been playing an important role in many fields. Besides their widespread use in particle-physics and nuclear-physics experiments, gaseous detectors are employed in many other fields: astro-particle research and applications such as medical imaging, material science, and security inspection. While extensively employed at the LHC, RHIC, and other advanced HEP experiments, present gaseous detectors (wire-chambers, drift-tubes, resistive-plate chambers and others) have limitations which may prevent their use in future experiments. Present tec...