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Sample records for plasma systemic exposure

  1. Vacuum System and Modeling for the Materials Plasma Exposure Experiment

    International Nuclear Information System (INIS)

    Lumsdaine, Arnold; Meitner, Steve; Graves, Van; Bradley, Craig; Stone, Chris

    2017-01-01

    Understanding the science of plasma-material interactions (PMI) is essential for the future development of fusion facilities. The design of divertors and first walls for the next generation of long-pulse fusion facilities, such as a Fusion Nuclear Science Facility (FNSF) or a DEMO, requires significant PMI research and development. In order to meet this need, a new linear plasma facility, the Materials Plasma Exposure Experiment (MPEX) is proposed, which will produce divertor relevant plasma conditions for these next generation facilities. The device will be capable of handling low activation irradiated samples and be able to remove and replace samples without breaking vacuum. A Target Exchange Chamber (TEC) which can be disconnected from the high field environment in order to perform in-situ diagnostics is planned for the facility as well. The vacuum system for MPEX must be carefully designed in order to meet the requirements of the different heating systems, and to provide conditions at the target similar to those expected in a divertor. An automated coupling-decoupling (“autocoupler”) system is designed to create a high vacuum seal, and will allow the TEC to be disconnected without breaking vacuum in either the TEC or the primary plasma materials interaction chamber. This autocoupler, which can be actuated remotely in the presence of the high magnetic fields, has been designed and prototyped, and shows robustness in a variety of conditions. The vacuum system has been modeled using a simplified finite element analysis, and indicates that the design goals for the pressures in key regions of the facility are achievable.

  2. A Study on Pharmacokinetics of Bosentan with Systems Modeling, Part 1: Translating Systemic Plasma Concentration to Liver Exposure in Healthy Subjects.

    Science.gov (United States)

    Li, Rui; Niosi, Mark; Johnson, Nathaniel; Tess, David A; Kimoto, Emi; Lin, Jian; Yang, Xin; Riccardi, Keith A; Ryu, Sangwoo; El-Kattan, Ayman F; Maurer, Tristan S; Tremaine, Larry M; Di, Li

    2018-04-01

    Understanding liver exposure of hepatic transporter substrates in clinical studies is often critical, as it typically governs pharmacodynamics, drug-drug interactions, and toxicity for certain drugs. However, this is a challenging task since there is currently no easy method to directly measure drug concentration in the human liver. Using bosentan as an example, we demonstrate a new approach to estimate liver exposure based on observed systemic pharmacokinetics from clinical studies using physiologically based pharmacokinetic modeling. The prediction was verified to be both accurate and precise using sensitivity analysis. For bosentan, the predicted pseudo steady-state unbound liver-to-unbound systemic plasma concentration ratio was 34.9 (95% confidence interval: 4.2, 50). Drug-drug interaction (i.e., CYP3A and CYP2B6 induction) and inhibition of hepatic transporters (i.e., bile salt export pump, multidrug resistance-associated proteins, and sodium-taurocholate cotransporting polypeptide) were predicted based on the estimated unbound liver tissue or plasma concentrations. With further validation and refinement, we conclude that this approach may serve to predict human liver exposure and complement other methods involving tissue biopsy and imaging. Copyright © 2018 by The American Society for Pharmacology and Experimental Therapeutics.

  3. TFTR plasma feedback systems

    International Nuclear Information System (INIS)

    Efthimion, P.; Hawryluk, R.J.; Hojsak, W.; Marsala, R.J.; Mueller, D.; Rauch, W.; Tait, G.D.; Taylor, G.; Thompson, M.

    1985-01-01

    The Tokamak Fusion Test Reactor employs feedback control systems for four plasma parameters, i.e. for plasma current, for plasma major radius, for plasma vertical position, and for plasma density. The plasma current is controlled by adjusting the rate of change of current in the Ohmic Heating (OH) coil system. Plasma current is continuously sensed by a Rogowski coil and its associated electronics; the error between it and a preprogrammed reference plasma current history is operated upon by a ''proportional-plusintegral-plus-derivative'' (PID) control algorithm and combined with various feedforward terms, to generate compensating commands to the phase-controlled thyristor rectifiers which drive current through the OH coils. The plasma position is controlled by adjusting the currents in Equilibrium Field and Horizontal Field coil systems, which respectively determine the vertical and radial external magnetic fields producing J X B forces on the plasma current. The plasma major radius position and vertical position, sensed by ''B /sub theta/ '' and ''B /sub rho/ '' magnetic flux pickup coils with their associated electronics, are controlled toward preprogrammed reference histories by allowing PID and feedforward control algorithms to generate commands to the EF and HF coil power supplies. Plasma density is controlled by adjusting the amount of gas injected into the vacuum vessel. Time-varying gains are used to combine lineaveraged plasma density measurements from a microwave interferometer plasma diagnostic system with vacuum vessel pressure measurements from ion gauges, with various other measurements, and with preprogrammed reference histories, to determine commands to piezoelectric gas injection valves

  4. Personal exposure control system

    International Nuclear Information System (INIS)

    Tanabe, Ken-ichi; Akashi, Michio

    1994-01-01

    Nuclear power stations are under strict radiation control. Exposure control for nuclear workers is the most important operation, and so carefully thought out measures are taken. This paper introduces Fuji Electric's personal exposure control system that meets strict exposure control and rationalizes control operations. The system has a merit that it can provide required information in an optimum form using the interconnection of a super minicomputer and exposure control facilities and realizes sophisticated exposure control operations. (author)

  5. Solar system plasma waves

    Science.gov (United States)

    Gurnett, Donald A.

    1995-01-01

    An overview is given of spacecraft observations of plasma waves in the solar system. In situ measurements of plasma phenomena have now been obtained at all of the planets except Mercury and Pluto, and in the interplanetary medium at heliocentric radial distances ranging from 0.29 to 58 AU. To illustrate the range of phenomena involved, we discuss plasma waves in three regions of physical interest: (1) planetary radiation belts, (2) planetary auroral acceleration regions and (3) the solar wind. In each region we describe examples of plasma waves that are of some importance, either due to the role they play in determining the physical properties of the plasma, or to the unique mechanism involved in their generation.

  6. Four exposure holography system

    International Nuclear Information System (INIS)

    Mix, L.P.; Kessler, R.W.

    1977-03-01

    A four exposure holographic interferometry system, designed for studying transient phenomena occurring on nanosecond time scales and particularly those associated with relativistic electron beams, is described. This system permits four holographic exposures of a single transient event to be made with independently adjustable interpulse spacings of from 6 to 28 nsec. The system is portable, allows for a wide range of image magnifications, features colinear scene beams to facilitate alignment and large aperture imaging lenses to minimize refraction phenomena. The various design parameters are discussed and typical holograms presented to indicate the types of data which may be obtained

  7. Quantitative plasma biomarker analysis in HDI exposure assessment.

    Science.gov (United States)

    Flack, Sheila L; Fent, Kenneth W; Trelles Gaines, Linda G; Thomasen, Jennifer M; Whittaker, Steve; Ball, Louise M; Nylander-French, Leena A

    2010-01-01

    Quantification of amines in biological samples is important for evaluating occupational exposure to diisocyanates. In this study, we describe the quantification of 1,6-hexamethylene diamine (HDA) levels in hydrolyzed plasma of 46 spray painters applying 1,6-hexamethylene diisocyanate (HDI)-containing paint in vehicle repair shops collected during repeated visits to their workplace and their relationship with dermal and inhalation exposure to HDI monomer. HDA was detected in 76% of plasma samples, as heptafluorobutyryl derivatives, and the range of HDA concentrations was HDA levels and HDI inhalation exposure measured on the same workday was low (N = 108, r = 0.22, P = 0.026) compared with the correlation between plasma HDA levels and inhalation exposure occurring approximately 20 to 60 days before blood collection (N = 29, r = 0.57, P = 0.0014). The correlation between plasma HDA levels and HDI dermal exposure measured on the same workday, although statistically significant, was low (N = 108, r = 0.22, P = 0.040) while the correlation between HDA and dermal exposure occurring approximately 20 to 60 days before blood collection was slightly improved (N = 29, r = 0.36, P = 0.053). We evaluated various workplace factors and controls (i.e. location, personal protective equipment use and paint booth type) as modifiers of plasma HDA levels. Workers using a downdraft-ventilated booth had significantly lower plasma HDA levels relative to semi-downdraft and crossdraft booth types (P = 0.0108); this trend was comparable to HDI inhalation and dermal exposure levels stratified by booth type. These findings indicate that HDA concentration in hydrolyzed plasma may be used as a biomarker of cumulative inhalation and dermal exposure to HDI and for investigating the effectiveness of exposure controls in the workplace.

  8. Plasma sources for EUV lithography exposure tools

    International Nuclear Information System (INIS)

    Banine, Vadim; Moors, Roel

    2004-01-01

    The source is an integral part of an extreme ultraviolet lithography (EUVL) tool. Such a source, as well as the EUVL tool, has to fulfil extremely high demands both technical and cost oriented. The EUVL tool operates at a wavelength in the range 13-14 nm, which requires a major re-thinking of state-of-the-art lithography systems operating in the DUV range. The light production mechanism changes from conventional lamps and lasers to relatively high temperature emitting plasmas. The light transport, mainly refractive for DUV, should become reflective for EUV. The source specifications are derived from the customer requirements for the complete tool, which are: throughput, cost of ownership (CoO) and imaging quality. The EUVL system is considered as a follow up of the existing DUV based lithography technology and, while improving the feature resolution, it has to maintain high wafer throughput performance, which is driven by the overall CoO picture. This in turn puts quite high requirements on the collectable in-band power produced by an EUV source. Increased, due to improved feature resolution, critical dimension (CD) control requirements, together with reflective optics restrictions, necessitate pulse-to-pulse repeatability, spatial stability control and repetition rates, which are substantially better than those of current optical systems. All together the following aspects of the source specification will be addressed: the operating wavelength, the EUV power, the hot spot size, the collectable angle, the repetition rate, the pulse-to-pulse repeatability and the debris induced lifetime of components

  9. Monitoring system for thermal plasma

    International Nuclear Information System (INIS)

    Romero G, M.; Vilchis P, A.E.

    1999-01-01

    In the Thermal plasma applications laboratory it has been the degradation project of oils for isolation in transformers. These are a very hazardous residues and at this time in the country they are stored in metal barrels. It has been the intention to undergo the oils to plasma for degradate them to non-hazardous residues. The system behavior must be monitored to establish the thermal plasma behavior. (Author)

  10. Nippon paint atmospheric plasma system

    International Nuclear Information System (INIS)

    Tsuchiya, Y.; Akutsu, K.

    1996-01-01

    An invitational plasma systems which are able to generate the wide and stable plasma (discharge distance 30 cm length, discharge electrode length max. 16 m) under normal air and pressure by using and narrow wave-form of pulse voltage has been developed. Its technical outline and some applied examples are reported

  11. Exposure to automotive pollution increases plasma susceptibility to oxidation.

    Science.gov (United States)

    Sharman, James E; Coombes, Jeff S; Geraghty, Dominic P; Fraser, David I

    2002-01-01

    Low-density lipoprotein oxidation is implicated in the development of atherosclerosis. Plasma susceptibility to oxidation may be used as a marker of low-density lipoprotein oxidation and thus predict atherosclerotic risk. In this study the authors investigated the relationship between plasma susceptibility to oxidation and exposure to automotive pollution in a group of automobile mechanics (n = 16) exposed to high levels of automotive pollution, vs. matched controls (n = 13). The authors induced plasma oxidation by a free radical initiator and they determined susceptibility to oxidation by (1) change in absorbance at 234 nm, (2) lag time to conjugated diene formation, and (3) linear slope of the oxidation curve. Mechanics had significantly higher values (mean +/- standard error) for change in absorbance (1.60 +/- 0.05 vs. 1.36 +/- 0.05; p automotive pollutants increases plasma susceptibility to oxidation and may, in the long-term, increase the risk of developing atherosclerosis.

  12. Pre-conceptual design activities for the materials plasma exposure experiment

    International Nuclear Information System (INIS)

    Lumsdaine, Arnold; Rapp, Juergen; Varma, Venugopal; Bjorholm, Thomas; Bradley, Craig; Caughman, John; Duckworth, Robert; Goulding, Richard; Graves, Van; Giuliano, Dominic; Lessard, Timothy; McGinnis, Dean; Meitner, Steven

    2016-01-01

    Highlights: • The development of long-pulse nuclear fusion devices requires testing plasma facing components at reactor relevant conditions. • The pre-conceptual design of a proposed linear plasma facility is presented. • Engineering considerations for multiple systems—plasma source and heating, magnet, vacuum, water cooling, and target, are presented. - Abstract: The development of next step fusion facilities such as DEMO or a Fusion Nuclear Science Facility (FNSF) requires first closing technology gaps in some critical areas. Understanding the material-plasma interface is necessary to enable the development of divertors for long-pulse plasma facilities. A pre-conceptual design for a proposed steady-state linear plasma device, the Materials Plasma Exposure Experiment (MPEX), is underway. A helicon plasma source along with ion cyclotron and electron Bernstein wave heating systems will produce ITER divertor relevant plasma conditions with steady-state parallel heat fluxes of up to 40 MW/m"2 with ion fluxes up to 10"2"4/m"2 s on target. Current plans are for the device to use superconducting magnets to produce 1–2 T fields. As a steady-state device, active cooling will be required for components that interact with the plasma (targets, limiters, etc.), as well as for other plasma facing components (transport regions, vacuum tanks, diagnostic ports). Design concepts for the vacuum system, the cooling system, and the plasma heating systems have been completed. The device will include the capability for handling samples that have been neutron irradiated in order to consider the multivariate effects of neutrons, plasma, and high heat-flux on the microstructure of divertor candidate materials. A vacuum cask, which can be disconnected from the high field environment in order to perform in-vacuo diagnosis of the surface evolution is also planned for the facility.

  13. Pre-conceptual design activities for the materials plasma exposure experiment

    Energy Technology Data Exchange (ETDEWEB)

    Lumsdaine, Arnold, E-mail: lumsdainea@ornl.gov; Rapp, Juergen; Varma, Venugopal; Bjorholm, Thomas; Bradley, Craig; Caughman, John; Duckworth, Robert; Goulding, Richard; Graves, Van; Giuliano, Dominic; Lessard, Timothy; McGinnis, Dean; Meitner, Steven

    2016-11-01

    Highlights: • The development of long-pulse nuclear fusion devices requires testing plasma facing components at reactor relevant conditions. • The pre-conceptual design of a proposed linear plasma facility is presented. • Engineering considerations for multiple systems—plasma source and heating, magnet, vacuum, water cooling, and target, are presented. - Abstract: The development of next step fusion facilities such as DEMO or a Fusion Nuclear Science Facility (FNSF) requires first closing technology gaps in some critical areas. Understanding the material-plasma interface is necessary to enable the development of divertors for long-pulse plasma facilities. A pre-conceptual design for a proposed steady-state linear plasma device, the Materials Plasma Exposure Experiment (MPEX), is underway. A helicon plasma source along with ion cyclotron and electron Bernstein wave heating systems will produce ITER divertor relevant plasma conditions with steady-state parallel heat fluxes of up to 40 MW/m{sup 2} with ion fluxes up to 10{sup 24}/m{sup 2} s on target. Current plans are for the device to use superconducting magnets to produce 1–2 T fields. As a steady-state device, active cooling will be required for components that interact with the plasma (targets, limiters, etc.), as well as for other plasma facing components (transport regions, vacuum tanks, diagnostic ports). Design concepts for the vacuum system, the cooling system, and the plasma heating systems have been completed. The device will include the capability for handling samples that have been neutron irradiated in order to consider the multivariate effects of neutrons, plasma, and high heat-flux on the microstructure of divertor candidate materials. A vacuum cask, which can be disconnected from the high field environment in order to perform in-vacuo diagnosis of the surface evolution is also planned for the facility.

  14. The Material Plasma Exposure eXperiment (MPEX)

    Science.gov (United States)

    Rapp, J.; Biewer, T. M.; Bigelow, T. S.; Canik, J.; Caughman, J. B. O.; Duckworth, R. C.; Goulding, R. H.; Hillis, D. L.; Lore, J. D.; Lumsdaine, A.; McGinnis, W. D.; Meitner, S. J.; Owen, L. W.; Shaw, G. C.; Luo, G.-N.

    2014-10-01

    Next generation plasma generators have to be able to access the plasma conditions expected on the divertor targets in ITER and future devices. The Material Plasma Exposure eXperiment (MPEX) will address this regime with electron temperatures of 1--10 eV and electron densities of 1021--1020 m-3. The resulting heat fluxes are about 10 MW/m2. MPEX is designed to deliver those plasma conditions with a novel Radio Frequency plasma source able to produce high density plasmas and heat electron and ions separately with Electron Bernstein Wave (EBW) heating and Ion Cyclotron Resonance Heating (ICRH). Preliminary modeling has been used for pre-design studies of MPEX. MPEX will be capable to expose neutron irradiated samples. In this concept targets will be irradiated in ORNL's High Flux Isotope Reactor (HFIR) or possibly at the Spallation Neutron Source (SNS) and then subsequently (after a sufficient long cool-down period) exposed to fusion reactor relevant plasmas in MPEX. The current state of the pre-design of MPEX including the concept of handling irradiated samples will be presented. ORNL is managed by UT-Battelle, LLC, for the U.S. DOE under Contract DE-AC-05-00OR22725.

  15. Exposures of tungsten nanostructures to divertor plasmas in DIII-D

    International Nuclear Information System (INIS)

    Rudakov, D L; Doerner, R P; Baldwin, M J; Boedo, J A; Hollmann, E M; Moyer, R A; Wong, C P C; Chrobak, C P; Guo, H Y; Leonard, A W; Pace, D C; Thomas, D M; Wright, G M; Abrams, T; Briesemeister, A R; McLean, A G; Fenstermacher, M E; Lasnier, C J; Watkins, J G

    2016-01-01

    Tungsten nanostructures (W-fuzz) prepared in the PISCES-A linear device have been found to survive direct exposure to divertor plasmas in DIII-D. W-fuzz was exposed in the lower divertor of DIII-D using the divertor material evaluation system. Two samples were exposed in lower single null (LSN) deuterium H-mode plasmas. The first sample was exposed in three discharges terminated by vertical displacement event disruptions, and the second in two discharges near the lowered X-point. More recently, three samples were exposed near the lower outer strike point in predominantly helium H-mode LSN plasmas. In all cases, the W-fuzz survived plasma exposure with little obvious damage except in the areas where unipolar arcing occurred. Arcing is effective in W-fuzz removal, and it appears that surfaces covered with W-fuzz can be more prone to arcing than smooth W surfaces. (paper)

  16. Tungsten and carbon surface change under high dose plasma exposure

    International Nuclear Information System (INIS)

    Martynenko, Y.V.; Khripunov, B.I.; Petrov, V.B.

    2009-01-01

    Study of surface composition dynamics has been made on the LENTA linear plasma simulator. Experiments have been made on tungsten and carbon materials subjected to steady-state plasma exposure. The achieved ion doses on the surface were 10 21 ion cm -2 . WL 10 tungsten containing 1% of La2O3 oxide and titanium-doped graphite RG-T were studied. The following experimental conditions were varied in these experiments: energy of ions, surface temperature, working gas. Irradiations of tungsten WL 10 were executed in deuterium plasma at low ion energies (about 20 eV) and at 200 eV for temperatures below 340 K. Graphite RG-T was exposed at 1300 K. Elevated surface temperature (about 1050K) was also characteristic of experiments on tungsten sample under nitrogen plasma impact (simulated inter-ELMs condition). Surface microstructure modification has been observed and surface composition changes were found on the materials showing influence of high dose plasma irradiations on element redistribution in the near surface layers. (author)

  17. JT-60 plasma control system

    International Nuclear Information System (INIS)

    Kurihara, K.

    1988-01-01

    JT-60 plasma control can be performed by the supervisory controller, the measurement system and actuators such as the poloidal field coil power supplies, gas injectors, neutral beam injection (NBI) heating system and radio frequency (RF) heating system. One of the most important characteristics of this system is a perfect digital control one composed of mini-computers, fast array processors and CAMAC modules, and it has large flexibility and few troubles to adjust the system. This system started to be operated in April 1985, after the six-year-long design, construction and testing, and have been operated and improved many times for two years. In this paper, the final system specification and its performance are presented aiming at the technological aspect of hardware and software. In addition, and experienced troubles are also presented. (author)

  18. Deuterium inventory in tungsten after plasma exposure. A microstructural survey

    International Nuclear Information System (INIS)

    Manhard, Armin

    2012-09-01

    Tungsten is a promising material for armouring the plasma-facing wall of future nuclear fusion experiments and power plants. It has a very high melting point, good thermal conductivity and is highly resistant against physical sputtering by energetic particles from the plasma. It also has a very low solubility for hydrogen isotopes. This is important both for safety and also for economic reasons, in particular with regard to the radioactive fusion fuel tritium. Due to this low solubility, the retention of hydrogen isotopes in tungsten materials after exposure to a plasma is dominated by the trapping of hydrogen isotopes at tungsten lattice defects. Therefore, a strong dependence of the hydrogen isotope retention on the microstructure of the tungsten is to be expected. This work describes a survey study of tungsten with different microstructures exposed to deuterium plasmas under a wide range of different plasma exposure conditions. The isotope deuterium was used because its natural abundance is much smaller than that of hydrogen (i.e., 1 H). This allows detecting even very small amounts retained in the tungsten practically without background signal. Furthermore, the use of deuterium allows utilising the nuclear reaction 2 D( 3 He,p) 4 He for depth-resolved quantification of the deuterium inventory up to depths of several microns. In order to standardise the specimens as far as possible, they were all cut from the same initial material from a single manufacturing batch. After a chemo-mechanical polishing procedure, which produces a well-defined surface, the specimens were annealed at either of four different temperatures in order to modify the grain structure and the dislocation density. These were then characterised by scanning electron microscopy and scanning transmission electron microscopy. The specimens were subsequently exposed in a fully characterised deuterium plasma source at different specimen temperatures, ion energies and deuterium fluences. In addition

  19. Global metabolomic profiling reveals an association of metal fume exposure and plasma unsaturated fatty acids.

    Directory of Open Access Journals (Sweden)

    Yongyue Wei

    Full Text Available Welding-associated air pollutants negatively affect the health of exposed workers; however, their molecular mechanisms in causing disease remain largely unclear. Few studies have systematically investigated the systemic toxic effects of welding fumes on humans.To explore the effects of welding fumes on the plasma metabolome, and to identify biomarkers for risk assessment of welding fume exposure.The two-stage, self-controlled exploratory study included 11 boilermakers from a 2011 discovery panel and 8 boilermakers from a 2012 validation panel. Plasma samples were collected pre- and post-welding fume exposure and analyzed by chromatography/mass spectrometry.Eicosapentaenoic or docosapentaenoic acid metabolic changes post-welding were significantly associated with particulate (PM2.5 exposure (p<0.05. The combined analysis by linear mixed-effects model showed that exposure was associated with a statistically significant decline in metabolite change of eicosapentaenoic acid [β(95% CI = -0.013(-0.022 ≈ -0.004; p = 0.005], docosapentaenoic acid n3 [β(95% CI = -0.010(-0.018 ≈ -0.002; p = 0.017], and docosapentaenoic acid n6 [β(95% CI = -0.007(-0.013 ≈ -0.001; p = 0.021]. Pathway analysis identified an association of the unsaturated fatty acid pathway with exposure (p Study-2011 = 0.025; p Study-2012 = 0.021; p Combined = 0.009. The functional network built by these fatty acids and their interactive genes contained significant enrichment of genes associated with various diseases, including neoplasms, cardiovascular diseases, and lipid metabolism disorders.High-dose exposure of metal welding fumes decreases unsaturated fatty acids with an exposure-response relationship. This alteration in fatty acids is a potential biological mediator and biomarker for exposure-related health disorders.

  20. Changes in Plasma Lipids during Exposure to Total Sleep Deprivation.

    Science.gov (United States)

    Chua, Eric Chern-Pin; Shui, Guanghou; Cazenave-Gassiot, Amaury; Wenk, Markus R; Gooley, Joshua J

    2015-11-01

    The effects of sleep loss on plasma lipids, which play an important role in energy homeostasis and signaling, have not been systematically examined. Our aim was to identify lipid species in plasma that increase or decrease reliably during exposure to total sleep deprivation. Twenty individuals underwent sleep deprivation in a laboratory setting. Blood was drawn every 4 h and mass spectrometry techniques were used to analyze concentrations of 263 lipid species in plasma, including glycerolipids, glycerophospholipids, sphingolipids, and sterols. Chronobiology and Sleep Laboratory, Duke-NUS Graduate Medical School. Healthy ethnic-Chinese males aged 21-28 y (n = 20). Subjects were kept awake for 40 consecutive hours. Each metabolite time series was modeled as a sum of sinusoidal (circadian) and linear components, and we assessed whether the slope of the linear component differed from zero. More than a third of all individually analyzed lipid profiles exhibited a circadian rhythm and/or a linear change in concentration during sleep deprivation. Twenty-five lipid species showed a linear and predominantly unidirectional trend in concentration levels that was consistent across participants. Choline plasmalogen levels decreased, whereas several phosphatidylcholine (PC) species and triacylglycerides (TAG) carrying polyunsaturated fatty acids increased. The decrease in choline plasmalogen levels during sleep deprivation is consistent with prior work demonstrating that these lipids are susceptible to degradation by oxidative stress. The increase in phosphatidylcholines and triacylglycerides suggests that sleep loss might modulate lipid metabolism, which has potential implications for metabolic health in individuals who do not achieve adequate sleep. © 2015 Associated Professional Sleep Societies, LLC.

  1. MHD stability analysis of helical system plasmas

    International Nuclear Information System (INIS)

    Nakamura, Yuji

    2000-01-01

    Several topics of the MHD stability studies in helical system plasmas are reviewed with respect to the linear and ideal modes mainly. Difference of the method of the MHD stability analysis in helical system plasmas from that in tokamak plasmas is emphasized. Lack of the cyclic (symmetric) coordinate makes an analysis more difficult. Recent topic about TAE modes in a helical system is also described briefly. (author)

  2. Design and Demonstration of a Material-Plasma Exposure Target Station for Neutron Irradiated Samples

    International Nuclear Information System (INIS)

    Rapp, Juergen; Aaron, A. M.; Bell, Gary L.; Burgess, Thomas W.; Ellis, Ronald James; Giuliano, D.; Howard, R.; Kiggans, James O.; Lessard, Timothy L.; Ohriner, Evan Keith; Perkins, Dale E.; Varma, Venugopal Koikal

    2015-01-01

    5-20 MW/m"2 and ion fluxes up to 10"2"4 m"-"2s"-"1. Since PFCs will have to withstand neutron irradiation displacement damage up to 50 dpa, the target station design must accommodate radioactive specimens (materials to be irradiated in HFIR or at SNS) to enable investigations of the impact of neutron damage on materials. Therefore, the system will have to be able to install and extract irradiated specimens using equipment and methods to avoid sample modification, control contamination, and minimize worker dose. Included in the design considerations will be an assessment of all the steps between neutron irradiation and post-exposure materials examination/characterization, as well as an evaluation of the facility hazard categorization. In particular, the factors associated with the acquisition of radioactive specimens and their preparation, transportation, experimental configuration at the plasma-specimen interface, post-plasma-exposure sample handling, and specimen preparation will be evaluated. Neutronics calculations to determine the dose rates of the samples were carried out for a large number of potential plasma-facing materials.

  3. MTX [Microwave Tokamak Experiment] plasma diagnostic system

    International Nuclear Information System (INIS)

    Rice, B.W.; Hooper, E.B.; Brooksby, C.A.

    1987-01-01

    In this paper, a general overview of the MTX plasma diagnostics system is given. This includes a description of the MTX machine configuration and the overall facility layout. The data acquisition system and techniques for diagnostic signal transmission are also discussed. In addition, the diagnostic instruments planned for both an initial ohmic-heating set and a second FEL-heating set are described. The expected range of plasma parameters along with the planned plasma measurements will be reviewed. 7 refs., 5 figs

  4. Non-thermal Plasma Exposure Rapidly Attenuates Bacterial AHL-Dependent Quorum Sensing and Virulence

    Science.gov (United States)

    Flynn, Padrig B.; Busetti, Alessandro; Wielogorska, Ewa; Chevallier, Olivier P.; Elliott, Christopher T.; Laverty, Garry; Gorman, Sean P.; Graham, William G.; Gilmore, Brendan F.

    2016-01-01

    The antimicrobial activity of atmospheric pressure non-thermal plasma has been exhaustively characterised, however elucidation of the interactions between biomolecules produced and utilised by bacteria and short plasma exposures are required for optimisation and clinical translation of cold plasma technology. This study characterizes the effects of non-thermal plasma exposure on acyl homoserine lactone (AHL)-dependent quorum sensing (QS). Plasma exposure of AHLs reduced the ability of such molecules to elicit a QS response in bacterial reporter strains in a dose-dependent manner. Short exposures (30–60 s) produce of a series of secondary compounds capable of eliciting a QS response, followed by the complete loss of AHL-dependent signalling following longer exposures. UPLC-MS analysis confirmed the time-dependent degradation of AHL molecules and their conversion into a series of by-products. FT-IR analysis of plasma-exposed AHLs highlighted the appearance of an OH group. In vivo assessment of the exposure of AHLs to plasma was examined using a standard in vivo model. Lettuce leaves injected with the rhlI/lasI mutant PAO-MW1 alongside plasma treated N-butyryl-homoserine lactone and n-(3-oxo-dodecanoyl)-homoserine lactone, exhibited marked attenuation of virulence. This study highlights the capacity of atmospheric pressure non-thermal plasma to modify and degrade AHL autoinducers thereby attenuating QS-dependent virulence in P. aeruginosa. PMID:27242335

  5. Design and Demonstration of a Material-Plasma Exposure Target Station for Neutron Irradiated Samples

    Energy Technology Data Exchange (ETDEWEB)

    Rapp, Juergen [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Aaron, A. M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Bell, Gary L. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Burgess, Thomas W. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Ellis, Ronald James [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Giuliano, D. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Howard, R. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Kiggans, James O. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Lessard, Timothy L. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Ohriner, Evan Keith [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Perkins, Dale E. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Varma, Venugopal Koikal [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-10-20

    -state heat fluxes of 5–20 MW/m2 and ion fluxes up to 1024 m-2s-1. Since PFCs will have to withstand neutron irradiation displacement damage up to 50 dpa, the target station design must accommodate radioactive specimens (materials to be irradiated in HFIR or at SNS) to enable investigations of the impact of neutron damage on materials. Therefore, the system will have to be able to install and extract irradiated specimens using equipment and methods to avoid sample modification, control contamination, and minimize worker dose. Included in the design considerations will be an assessment of all the steps between neutron irradiation and post-exposure materials examination/characterization, as well as an evaluation of the facility hazard categorization. In particular, the factors associated with the acquisition of radioactive specimens and their preparation, transportation, experimental configuration at the plasma-specimen interface, post-plasma-exposure sample handling, and specimen preparation will be evaluated. Neutronics calculations to determine the dose rates of the samples were carried out for a large number of potential plasma-facing materials.

  6. Analyses of metallic first mirror samples after long term plasma exposure in Tore Supra

    International Nuclear Information System (INIS)

    Lipa, M.; Schunke, B.; Gil, Ch.; Bucalossi, J.; Voitsenya, V.S.; Konovalov, V.; Vukolov, K.; Balden, M.; De Temmerman, G.; Oelhafen, P.; Litnovsky, A.; Wienhold, P.

    2006-01-01

    Metallic mirrors are foreseen in ITER diagnostic systems as optical elements directly viewing the plasma radiation. In the frame of an EFDA contract, metallic mirror samples have been exposed for long pulse plasma discharges in Tore Supra (TS) in order to investigate surface modifications caused by erosion and re-deposition processes. Three different materials have been selected: mono-crystalline molybdenum (mc-Mo), polycrystalline stainless steel (SS) and copper (Cu). The mc-Mo samples showed after TS exposure almost no surface roughness modifications and the lowest net-erosion. A slight reflectivity reduction, most pronounced in the near UV, is attributed to light absorption in a thin carbon deposit. Cu mirrors showed by far the highest surface roughness, erosion and diffusive reflectivity. Comparative laboratory glow discharge experiments with virgin reference samples and numerical simulations of erosion/deposition confirm the dominant contribution of conditioning procedures to erosion of mirrors exposed (without shutter protection) in Tore Supra

  7. A new radiation exposure record system

    International Nuclear Information System (INIS)

    Lyon, M.; Berndt, V.L.; Trevino, G.W.; Oakley, B.M.

    1993-04-01

    The Hanford Radiological Records Program (HRRP) serves all Hanford contractors as the single repository for radiological exposure for all Hanford employees, subcontractors, and visitors. The program administers and preserves all Hanford radiation exposure records. The program also maintains a Radiation Protection Historical File which is a historical file of Hanford radiation protection and dosimetry procedures and practices. Several years ago DOE declared the existing UNIVAC mainframe computer obsolete and the existing Occupational Radiation Exposure (ORE) system was slated to be redeveloped. The new system named the Radiological Exposure (REX) System is described in this document

  8. Cryogenic Considerations for Superconducting Magnet Design for the Material Plasma Exposure eXperiment

    Energy Technology Data Exchange (ETDEWEB)

    Duckworth, Robert C [ORNL; Demko, Dr. Jonathan A [LeTourneau University, Texas; Lumsdaine, Arnold [ORNL; Caughman, John B [ORNL; Goulding, Richard Howell [ORNL; McGinnis, William Dean [ORNL; Bjorholm, Thomas P [ORNL; Rapp, Juergen [ORNL

    2015-01-01

    In order to determine long term performance of plasma facing components such as diverters and first walls for fusion devices, next generation plasma generators are needed. A Material Plasma Exposure eXperiment (MPEX) has been proposed to address this need through the generation of plasmas in front of the target with electron temperatures of 1-15 eV and electron densities of 1020 to 1021 m-3. Heat fluxes on target diverters could reach 20 MW/m2. In order generate this plasma, a unique radio frequency helicon source and heating of electrons and ions through Electron Bernstein Wave (EBW) and Ion Cyclotron Resonance Heating (ICRH) has been proposed. MPEX requires a series of magnets with non-uniform central fields up to 2 T over a 5m length in the heating and transport region and 1 T uniform central field over a 1-m length on a diameter of 1.3 m. Given the field requirements, superconducting magnets are under consideration for MPEX. In order to determine the best construction method for the magnets, the cryogenic refrigeration has been analyzed with respect to cooldown and operational performance criteria for open-cycle and closed-cycle systems, capital and operating costs of these system, and maturity of supporting technology such as cryocoolers. These systems will be compared within the context of commercially available magnet constructions to determine the most economical method for MPEX operation. The current state of the MPEX magnet design including details on possible superconducting magnet configurations will be presented.

  9. Relaxed plasma-vacuum systems

    International Nuclear Information System (INIS)

    Spies, G.O.; Lortz, D.; Kaiser, R.

    2001-01-01

    Taylor's theory of relaxed toroidal plasmas (states of lowest energy with fixed total magnetic helicity) is extended to include a vacuum between the plasma and the wall. In the extended variational problem, one prescribes, in addition to the helicity and the magnetic fluxes whose conservation follows from the perfect conductivity of the wall, the fluxes whose conservation follows from the assumption that the plasma-vacuum interface is also perfectly conducting (if the wall is a magnetic surface, then one has the toroidal and the poloidal flux in the vacuum). Vanishing of the first energy variation implies a pressureless free-boundary magnetohydrostatic equilibrium with a Beltrami magnetic field in the plasma, and in general with a surface current in the interface. Positivity of the second variation implies that the equilibrium is stable according to ideal magnetohydrodynamics, that it is a relaxed state according to Taylor's theory if the interface is replaced by a wall, and that the surface current is nonzero (at least if there are no closed magnetic field lines in the interface). The plane slab, with suitable boundary conditions to simulate a genuine torus, is investigated in detail. The relaxed state has the same double symmetry as the vessel if, and only if, the prescribed helicity is in an interval that depends on the prescribed fluxes. This interval is determined in the limit of a thin slab

  10. Exposure of tungsten nano-structure to TEXTOR edge plasma

    International Nuclear Information System (INIS)

    Ueda, Y.; Miyata, K.; Ohtsuka, Y.; Lee, H.T.; Fukumoto, M.; Brezinsek, S.; Coenen, J.W.; Kreter, A.; Litnovsky, A.; Philipps, V.; Schweer, B.; Sergienko, G.; Hirai, T.; Taguchi, A.; Torikai, Y.; Sugiyama, K.; Tanabe, T.; Kajita, S.; Ohno, N.

    2011-01-01

    W nano-structures (fuzz), produced in the linear high plasma device, NAGDIS, were exposed to TEXTOR edge plasmas (ohmic He/D mixed plasma and pure D plasma) to study formation, erosion and C deposition on W fuzz in tokamak plasmas for the first time. Fuzz layers were either completely eroded or covered by C deposit. There was no clear indication of W fuzz growth under the present conditions. There was no significant difference of C deposition between 'thick' fuzz (500-600 nm in thickness) and 'thin' fuzz (300-400 nm) in the He/D plasma. On the W fuzz surface, C deposition was enhanced probably due to reduction of effective sputtering yield and effective reflection coefficient of carbon ions, similar to roughness effects. Formation and erosion of W fuzz in tokamak devices and role of impurities are discussed.

  11. Tritium retention in S-65 beryllium after 100 eV plasma exposure

    Energy Technology Data Exchange (ETDEWEB)

    Causey, R.A. [Sandia National Labs., Livermore, CA (United States); Longhurst, G.R. [Idaho National Engineering Laboratories, Idaho Falls, 83415 (United States); Harbin, W. [Los Alamos National Laboratories, Los Alamos, NM 87545 (United States)

    1997-02-01

    The tritium plasma experiment (TPE) has been used to measure the retention of tritium in S-65 beryllium under conditions similar to that expected for the international thermonuclear experimental reactor (ITER). Beryllium samples 2 mm thick and 50 mm in diameter were exposed to a plasma of tritium and deuterium. The particle flux striking the samples was varied from approximately 1 x 10{sup 17} (D+T)/cm{sup 2} s up to about 3 x 10{sup 18} (D+T)/cm{sup 2} s. The beryllium samples were negatively biased to elevate the energy of the impinging ions to 100 eV. The temperature of the samples was varied from 373 K to 973 K. Exposure times of 1 h were used. Subsequent to the plasma exposure, the samples were outgassed in a separate system where 99% He and 1% H{sub 2} gas was swept over the samples during heating. The sweep gas along with the released tritium was sent through an ionization chamber, through a copper oxide catalyst bed, and into a series of glycol bubblers. The amount of released tritium was determined both by the ionization chamber and by liquid scintillation counting of the glycol. Tritium retention in the beryllium disks varied from a high of 2.4 x 10{sup 17} (D+T)/cm{sup 2} at 373 K to a low of 1 x 10{sup 16} (D+T)/cm{sup 2} at 573 K. For almost every case, the tritium retention in the beryllium was less than that calculated using the C=0 boundary condition at the plasma facing surface. It is believed that this lower than expected retention is due to rapid release of tritium from the large specific surface area created in the implant zone due to the production of voids, bubbles, and blisters. (orig.).

  12. Tritium retention in S-65 beryllium after 100 eV plasma exposure

    Science.gov (United States)

    Causey, Rion A.; Longhurst, Glen R.; Harbin, Wally

    1997-02-01

    The tritium plasma experiment (TPE) has been used to measure the retention of tritium in S-65 beryllium under conditions similar to that expected for the international thermonuclear experimental reactor (ITER). Beryllium samples 2 mm thick and 50 mm in diameter were exposed to a plasma of tritium and deuterium. The particle flux striking the samples was varied from approximately 1 × 10 17 ( D + T)/ cm2s up to about 3 × 10 18 ( D + T)/ cm2s. The beryllium samples were negatively biased to elevate the energy of the impinging ions to 100 eV. The temperature of the samples was varied from 373 K to 973 K. Exposure times of 1 h were used. Subsequent to the plasma exposure, the samples were outgassed in a separate system where 99% He and 1% H 2 gas was swept over the samples during heating. The sweep gas along with the released tritium was sent through an ionization chamber, through a copper oxide catalyst bed, and into a series of glycol bubblers. The amount of released tritium was determined both by the ionization chamber and by liquid scintillation counting of the glycol. Tritium retention in the beryllium disks varied from a high of 2.4 × 10 17 ( D + T)/ cm2 at 373 K to a low of 1 × 10 16 ( D + T)/ cm2 at 573 K. For almost every case, the tritium retention in the beryllium was less than that calculated using the C = 0 boundary condition at the plasma facing surface. It is believed that this lower than expected retention is due to rapid release of tritium from the large specific surface area created in the implant zone due to the production of voids, bubbles, and blisters.

  13. In vivo plasma concentration for lindane after 6 hour exposure in human skin

    Data.gov (United States)

    U.S. Environmental Protection Agency — Dataset is a time course description of lindane disappearance in blood plasma after dermal exposure in human volunteers. This dataset is associated with the...

  14. PLASMA AND LUNG MACROPHAGE CAROTENOID RESPONSIVENESS TO SUPPLEMENTATION AND OZONE EXPOSURE IN HUMANS

    Science.gov (United States)

    OBJECTIVE:: To examine the effect of ozone exposure and vegetable juice supplementation on plasma and lung macrophage concentrations of carotenoids. DESIGN:: A randomized trial. SETTING:: Subjects were exposed to ambient air prior to antioxidant supplementation and to ozone after...

  15. Nickel exposure and plasma levels of biomarkers for assessing oxidative stress in nickel electroplating workers.

    Science.gov (United States)

    Tsao, Yu-Chung; Gu, Po-Wen; Liu, Su-Hsun; Tzeng, I-Shiang; Chen, Jau-Yuan; Luo, Jiin-Chyuan John

    2017-07-01

    The mechanism of nickel-induced pathogenesis remains elusive. To examine effects of nickel exposure on plasma oxidative and anti-oxidative biomarkers. Biomarker data were collected from 154 workers with various levels of nickel exposure and from 73 controls. Correlations between nickel exposure and oxidative and anti-oxidative biomarkers were determined using linear regression models. Workers with a exposure to high nickel levels had significantly lower levels of anti-oxidants (glutathione and catalase) than those with a lower exposure to nickel; however, only glutathione showed an independent association after multivariable adjustment. Exposure to high levels of nickel may reduce serum anti-oxidative capacity.

  16. Initial damage processes for diamond film exposure to hydrogen plasma

    International Nuclear Information System (INIS)

    Deslandes, A.; Guenette, M.C.; Samuell, C.M.; Karatchevtseva, I.; Ionescu, M.; Cohen, D.D.; Blackwell, B.; Corr, C.; Riley, D.P.

    2013-01-01

    Graphical abstract: -- Highlights: • Exposing chemical vapour deposited (CVD) diamond films in a recently constructed device, MAGPIE, specially commissioned to simulate fusion plasma conditions. • Non-diamond material is etched from the diamond. • There is no hydrogen retention observed, which suggests diamond is an excellent candidate for plasma facing materials. • Final structure of the surface is dependent on synergistic effects of etching and ion-induced structural change. -- Abstract: Diamond is considered to be a possible alternative to other carbon based materials as a plasma facing material in nuclear fusion devices due to its high thermal conductivity and resistance to chemical erosion. In this work CVD diamond films were exposed to hydrogen plasma in the MAGnetized Plasma Interaction Experiment (MAGPIE): a linear plasma device at the Australian National University which simulates plasma conditions relevant to nuclear fusion. Various negative sample stage biases of magnitude less than 500 V were applied to control the energies of impinging ions. Characterisation results from SEM, Raman spectroscopy and ERDA are presented. No measureable quantity of hydrogen retention was observed, this is either due to no incorporation of hydrogen into the diamond structure or due to initial incorporation as a hydrocarbon followed by subsequent etching back into the plasma. A model is presented for the initial stages of diamond erosion in fusion relevant hydrogen plasma that involves chemical erosion of non-diamond material from the surface by hydrogen radicals and damage to the subsurface region from energetic hydrogen ions. These results show that the initial damage processes in this plasma regime are comparable to previous studies of the fundamental processes as reported for less extreme plasma such as in the development of diamond films

  17. Imaging axial and radial electric field components in dielectric targets under plasma exposure

    NARCIS (Netherlands)

    Slikboer, E.T.; Sobota, A.; Guaitella, O.; Garcia-Caurel, E.

    2018-01-01

    This work presents new ways to investigate the individual electric field components in a dielectric target induced by a non thermal atmospheric pressure plasma jet. Mueller polarimetry is applied to investigate electro-optic crystals under exposure of guided ionization waves produced by a plasma

  18. EXPOSURE ANALYSIS MODELING SYSTEM (EXAMS): USER MANUAL AND SYSTEM DOCUMENTATION

    Science.gov (United States)

    The Exposure Analysis Modeling System, first published in 1982 (EPA-600/3-82-023), provides interactive computer software for formulating aquatic ecosystem models and rapidly evaluating the fate, transport, and exposure concentrations of synthetic organic chemicals - pesticides, ...

  19. MFTF-B plasma-diagnostic system

    International Nuclear Information System (INIS)

    Throop, A.L.; Goerz, D.A.; Thomas, S.R.

    1981-01-01

    This paper describes the current design status of the plasma diagnostic system for MFTF-B. In this paper we describe the system requirement changes which have occurred as a result of the funded rescoping of the original MFTF facility into MFTF-B. We outline the diagnostic instruments which are currently planned, and present an overview of the diagnostic system

  20. Electromagnetic induction phenomena in plasma systems

    International Nuclear Information System (INIS)

    Karlovitz, B.

    1982-01-01

    The phenomenon of electromagnetic induction is considered in complex high temperature plasma systems. Thermal energy of such fully ionized plasma is really energy of the magnetic vortex fields surrounding the randomly moving ions and electrons. In an expanding plasma stream, moving across the containing magnetic field, random thermal motion of the ions and electrons is converted into ordered motion and thereby random magnetic energy of the plasma into magnetic energy of an ordered field. Consequently, in contrast to simple systems consisting of coils and magnets only, an expanding plasma stream can maintain net outflow of ordered magnetic energy from a closed volume for an indefinite length of time. Conversion of thermal energy of plasma into ordered magnetic energy by the thermodynamic expansion process leads to the expectation of a new induction phenomenon: the generation of a unidirectional induced electromotive force of unlimited duration, measured in a closed loop at rest relative to the magnetic field, by the expansion work of the plasma stream. No change is required in the differential form of Maxwell's equations for the existence of this induction phenomenon, only the definition of the concept of rate of change of magnetic flux needs to be modified in the macroscopic equations to correspond to the rate of flow of magnetic energy across a closed surface. An experimental test of the predicted induction phenomenon is proposed

  1. Plasma-chemical processes and systems

    International Nuclear Information System (INIS)

    Castro B, J.

    1987-01-01

    The direct applications of plasma technology on chemistry and metallurgy are presented. The physical fundaments of chemically active non-equilibrium plasma, the reaction kinetics, and the physical chemical transformations occuring in the electrical discharges, which are applied in the industry, are analysed. Some plasma chemical systems and processes related to the energy of hydrogen, with the chemical technology and with the metallurgy are described. Emphasis is given to the optimization of the energy effectiveness of these processes to obtain reducers and artificial energetic carriers. (M.C.K.) [pt

  2. System for the production of plasma

    International Nuclear Information System (INIS)

    Bakken, G.S.

    1978-01-01

    The present invention provides a system for the production of a plasma by concentrating and focusing a laser beam on the plasma-forming material with a light focusing member which comprises a parabolic axicon in conjunction with a coaxial conical mirror. The apex of the conical mirror faces away from the focus of the parabolic axicon such that the conical mirror serves to produce a virtual line source along the axis of the cone. Consequently, irradiation from a laser parallel to the axis toward the apex of the conical mirror will be concentrated at the focus of the parabolic axicon, impinging upon the plasma-forming material there introduced to produce a plasma. The system is adaptable to irradiation of a target pellet introduced at the focus of the parabolic axicon and offers an advantage in that the target pellet can be irradiated with a high degree of radial and spherical symmetry

  3. Persistent depletion of plasma gelsolin (pGSN) after exposure of mice to heavy silicon ions

    Science.gov (United States)

    Rithidech, Kanokporn Noy; Reungpatthanaphong, Paiboon; Tungjai, Montree; Jangiam, Witawat; Honikel, Louise; Whorton, Elbert B.

    2018-05-01

    Little is known about plasma proteins that can be used as biomarkers for early and late responses to radiation. The purpose of this study was to determine a link between depletion of plasma gelsolin (pGSN) and cell-death as well as inflammatory responses in the lung (one of the tissues known to be radiosensitive) of the same exposed CBA/CaJ mice after exposure to heavy silicon (28Si) ions. To prevent the development of multiple organ dysfunctions, pGSN (an important component of the extracellular actin-scavenging system) is responsible for the removal of actin that is released into the circulation during inflammation and from dying cells. We evaluated the levels of pGSN in plasma collected from groups of mice (5 mice in each) at 1 week (wk) and 1 month (1 mo) after exposure whole body to different doses of 28Si ions, i.e. 0, 0.1, 0.25, or 0.5 Gy (2 fractionated exposures, 15 days apart that totaled each selected dose). In the same mouse, the measurements of pGSN levels were coupled with the quantitation of injuries in the lung, determined by (a) the levels of cleaved poly (ADP-ribose) polymerase (cleaved-PARP), a marker of apoptotic cell-death, (b) the levels of activated nuclear factor-kappa B (NF-κB) and selected cytokines, i.e. tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), and IL-6, from tissue-lysates of the lung. Further, the ratio of neutrophils and lymphocytes (N/L) was determined in the same mouse. Our data indicated: (i) the magnitude of pGSN depletion was dependent to radiation dose at both harvest times, (ii) a persistent depletion of pGSN up to 1 mo post-exposure to 0.25 or 0.5 Gy of 28Si ions, (iii) an inverse-correlation between pGSN depletion and increased levels of cleaved-PARP, including activated NF-κB/pro-inflammatory cytokines in the lung, and (iv) at both harvest times, statistically significant increases in the N/L ratio in groups of mice exposed to 0.5 Gy only. Our findings suggested that depletion in pGSN levels

  4. Systemic Absorption of Nanomaterials by Oral Exposure

    DEFF Research Database (Denmark)

    Binderup, Mona-Lise; Bredsdorff, Lea; Beltoft, Vibe Meister

    This report and accompanying database systematically evaluates the reliability and relevance of the existing scientific literature regarding systemic absorption of nanomaterials by oral exposure and makes specific recommendations for future testing approaches.......This report and accompanying database systematically evaluates the reliability and relevance of the existing scientific literature regarding systemic absorption of nanomaterials by oral exposure and makes specific recommendations for future testing approaches....

  5. Optical fibres for fusion plasma diagnostics systems

    International Nuclear Information System (INIS)

    Brichard, B.

    2005-01-01

    The condition to achieve and maintain the ignition of a thermonuclear fusion plasma ignition calls for the construction of a large scale fusion reactor, namely ITER. This reactor is designed to deliver an average fusion power of 500 MW. The burning of fusion plasma at such high power level will release a tremendous amount of energy in the form of particle fluxes and ionising radiation. This energy release, primarily absorbed by the plasma facing components, can significantly degrade the performances of the plasma diagnostic equipment surrounding the machine. To ensure a correct operation of the Tokamak we need to develop highly radiation-resistance devices. In plasma diagnostic systems, optical fibre is viewed as a convenient tool to transport light from the plasma edge to the diagnostic area. Radiation affects the optical performances of the fibre mainly by the occurrence of radiation-induced absorption and luminescence. Both effects degrade the light signal used for plasma diagnostic. SCK-CEN is currently assessing radiation-resistant glasses for optical fibres and is developing the associated qualification procedure. The main objectives of this study were to increase the lifetime of optical components in high radiation background and to develop a radiation resistance optical fibre capable to operate in the radiation background of ITER

  6. Observation of non-uniform erosion and deposition phenomena on graphite after plasma exposure

    International Nuclear Information System (INIS)

    Hildebrandt, D.; Grote, H.; Schneider, W.; Wienhold, P.; Seggern, J. von

    1999-01-01

    The modifications of fine grain isotropic graphite surfaces after plasma exposure have been investigated using surface analysis techniques with high spatial resolution in area and depth. The samples are graphite target tiles of ASDEX-upgrade and coated graphite collector samples exposed for special erosion/deposition experiments in the divertor plasma of ASDEX-upgrade or in the scrape-off plasma of TEXTOR-94. In addition, a graphite sample was exposed to a low temperature, clean deuterium plasma to study the modifications of the surface morphology during plasma exposure. The results give clear indications of non-uniform erosion and deposition processes. The change of the surface morphology during these processes is discussed. (orig.)

  7. Mirror fusion test facility plasma diagnostics system

    International Nuclear Information System (INIS)

    Thomas, S.R. Jr.; Coffield, F.E.; Davis, G.E.; Felker, B.

    1979-01-01

    During the past 25 years, experiments with several magnetic mirror machines were performed as part of the Magnetic Fusion Energy (MFE) Program at LLL. The latest MFE experiment, the Mirror Fusion Test Facility (MFTF), builds on the advances of earlier machines in initiating, stabilizing, heating, and sustaining plasmas formed with deuterium. The goals of this machine are to increase ion and electron temperatures and show a corresponding increase in containment time, to test theoretical scaling laws of plasma instabilities with increased physical dimensions, and to sustain high-beta plasmas for times that are long compared to the energy containment time. This paper describes the diagnostic system being developed to characterize these plasma parameters

  8. Plasma control system upgrade and increased plasma stability in NSTX

    Energy Technology Data Exchange (ETDEWEB)

    Mastrovito, D., E-mail: dmastrovito@pppl.go [Princeton Plasma Physics Laboratory, P.O. Box 451 Princeton, NJ 08543 (United States); Gates, D.; Gerhard, S.; Lawson, J.; Ludescher-Furth, C.; Marsala, R. [Princeton Plasma Physics Laboratory, P.O. Box 451 Princeton, NJ 08543 (United States)

    2010-07-15

    Plasma control on the National Spherical Torus Experiment (NSTX) was previously accomplished using eight 333 MHz G4 processors built by Sky computers. Several planned improvements and additional control algorithms required significant upgrades to our real-time control computers and real-time data acquisition infrastructure. Several in-house modules have been designed and implemented including: the digital time stamp module (DITS) and for digital/analog front panel data port (FPDP) output, the FPDP output module digital/analog (FOMD/A). Standard Linux based Intel computers perform the real-time control tasks and InfiniBand as been employed for communication between a user-accessible 'host' server and the real-time computer. In addition to several independent real-time processes the General Atomics developed PCS (Bell (2006) ) system infrastructure continues to be used on NSTX. While maintaining previous functionality, improvements in the control system software include: an RWM feedback algorithm, beta feedback NBI control, more comprehensive error logging and trapping, more user-friendly interface, more complete archiving and restoring functionality, and better status reporting and diagnostic tools. Once completed, we succeeded in increasing overall plasma stability and decreasing control system latency by several times.

  9. Plasma Discharge in Toroidal System

    International Nuclear Information System (INIS)

    Usada, Widdi; Suryadi; Purwadi, Agus; Kasiyo

    1996-01-01

    A toroidal discharge apparatus has been made as an initial research in magnetic confinement system. This system consists of a capacitor, a RF source, an igniter system, a primary coil, a torus, and completed by Rogowski probe as a current detector. In this system, the discharge occurs when the minimum voltage is operated at 5 kV. The experiment result shows that the coupling factor is 0.35, it is proved that there is an equality between estimated and measurement results of the primary inductance i.e 8.5 μH

  10. Progress in the Development of a High Power Helicon Plasma Source for the Materials Plasma Exposure Experiment

    Energy Technology Data Exchange (ETDEWEB)

    Goulding, Richard Howell [ORNL; Caughman, John B. [ORNL; Rapp, Juergen [ORNL; Biewer, Theodore M. [ORNL; Bigelow, Tim S. [ORNL; Campbell, Ian H. [ORNL; Caneses Marin, Juan F. [ORNL; Donovan, David C. [ORNL; Kafle, Nischal [ORNL; Martin, Elijah H. [ORNL; Ray, Holly B. [ORNL; Shaw, Guinevere C. [ORNL; Showers, Melissa A. [ORNL

    2017-09-01

    Proto-MPEX is a linear plasma device being used to study a novel RF source concept for the planned Material Plasma Exposure eXperiment (MPEX), which will address plasma-materials interaction (PMI) for nuclear fusion reactors. Plasmas are produced using a large diameter helicon source operating at a frequency of 13.56 MHz at power levels up to 120 kW. In recent experiments the helicon source has produced deuterium plasmas with densities up to ~6 × 1019 m–3 measured at a location 2 m downstream from the antenna and 0.4 m from the target. Previous plasma production experiments on Proto-MPEX have generated lower density plasmas with hollow electron temperature profiles and target power deposition peaked far off axis. The latest experiments have produced flat Te profiles with a large portion of the power deposited on the target near the axis. This and other evidence points to the excitation of a helicon mode in this case.

  11. Plasma exposure of different tungsten grades with plasma accelerators under ITER-relevant conditions

    International Nuclear Information System (INIS)

    Makhlaj, Vadym A; Garkusha, Igor E; Aksenov, Nikolay N; Byrka, Oleg V; Bazylev, Boris; Landman, Igor; Linke, Jochen; Wirtz, Marius; Malykhin, Sergey V; Pugachov, Anatoliy T; Sadowski, Marek J; Skladnik-Sadowska, Elzbieta

    2014-01-01

    This paper presents the results of tungsten irradiation experiments performed with three plasma facilities: the QSPA Kh-50 quasi-steady-state plasma accelerator, the PPA pulsed plasma gun and the magneto-plasma compressor. Targets made of different kinds of tungsten (sintered, rolled and deformed) were irradiated with powerful plasma streams at heat fluxes relevant to edge-localized modes in ITER. The irradiated targets were analyzed and two different meshes of cracks were identified. It has been shown that the major cracks do not depend on the tungsten grade. This has been attributed to ductile-to-brittle transition effects. Meshes of inter-granular micro-cracks were detected for energy loads above the melting threshold and these were probably caused by the re-solidification process. The blister-like and cellular-like structures were observed on sample surfaces exposed to helium and hydrogen plasmas. (paper)

  12. Theory and Simulations of Solar System Plasmas

    Science.gov (United States)

    Goldstein, Melvyn L.

    2011-01-01

    "Theory and simulations of solar system plasmas" aims to highlight results from microscopic to global scales, achieved by theoretical investigations and numerical simulations of the plasma dynamics in the solar system. The theoretical approach must allow evidencing the universality of the phenomena being considered, whatever the region is where their role is studied; at the Sun, in the solar corona, in the interplanetary space or in planetary magnetospheres. All possible theoretical issues concerning plasma dynamics are welcome, especially those using numerical models and simulations, since these tools are mandatory whenever analytical treatments fail, in particular when complex nonlinear phenomena are at work. Comparative studies for ongoing missions like Cassini, Cluster, Demeter, Stereo, Wind, SDO, Hinode, as well as those preparing future missions and proposals, like, e.g., MMS and Solar Orbiter, are especially encouraged.

  13. Inflammatory cytokines and plasma redox status responses in hypertensive subjects after heat exposure

    Directory of Open Access Journals (Sweden)

    S.F. Fonseca

    2016-03-01

    Full Text Available Hypertension is characterized by a pro-inflammatory status, including redox imbalance and increased levels of pro-inflammatory cytokines, which may be exacerbated after heat exposure. However, the effects of heat exposure, specifically in individuals with inflammatory chronic diseases such as hypertension, are complex and not well understood. This study compared the effects of heat exposure on plasma cytokine levels and redox status parameters in 8 hypertensive (H and 8 normotensive (N subjects (age: 46.5±1.3 and 45.6±1.4 years old, body mass index: 25.8±0.8 and 25.6±0.6 kg/m2, mean arterial pressure: 98.0±2.8 and 86.0±2.3 mmHg, respectively. They remained at rest in a sitting position for 10 min in a thermoneutral environment (22°C followed by 30 min in a heated environmental chamber (38°C and 60% relative humidity. Blood samples were collected before and after heat exposure. Plasma cytokine levels were measured using sandwich ELISA kits. Plasma redox status was determined by thiobarbituric acid reactive substances (TBARS levels and ferric reducing ability of plasma (FRAP. Hypertensive subjects showed higher plasma levels of IL-10 at baseline (P<0.05, although levels of this cytokine were similar between groups after heat exposure. Moreover, after heat exposure, hypertensive individuals showed higher plasma levels of soluble TNF receptor (sTNFR1 and lower TBARS (P<0.01 and FRAP (P<0.05 levels. Controlled hypertensive subjects, who use angiotensin-converting-enzyme inhibitor (ACE inhibitors, present an anti-inflammatory status and balanced redox status. Nevertheless, exposure to a heat stress condition seems to cause an imbalance in the redox status and an unregulated inflammatory response.

  14. Isoniazid concentrations in hair and plasma area-under-the-curve exposure among children with tuberculosis.

    Directory of Open Access Journals (Sweden)

    Vidya Mave

    Full Text Available We measured hair and plasma concentrations of isoniazid among sixteen children with tuberculosis who underwent personal or video-assisted directly observed therapy and thus had 100% adherence. This study therefore defined typical isoniazid exposure parameters after two months of treatment among fully-adherent patients in both hair and plasma (plasma area under the concentration-time curve, AUC, estimated using pharmacokinetic data collected 0, 2, 4, and 6 hours after drug administration. We found that INH levels in hair among highly-adherent individuals did not correlate well with plasma AUC or trough concentrations, suggesting that each measure may provide incremental and complementary information regarding drug exposure in the context of TB treatment.

  15. Integrated occupational radiation exposure information system

    International Nuclear Information System (INIS)

    Hunt, H.W.

    1983-06-01

    The integrated (Occupational Radiation Exposure) data base information system has many advantages. Radiation exposure information is available to operating management in a more timely manner and in a more flexible mode. The ORE system has permitted the integration of scattered files and data to be stored in a more cost-effective method that permits easy and simultaneous access by a variety of users with different data needs. The external storage needs of the radiation exposure source documents are several orders of magnitude less through the use of the computer assisted retrieval techniques employed in the ORE system. Groundwork is being layed to automate the historical files, which are maintained to help describe the radiation protection programs and policies at any one point in time. The file unit will be microfilmed for topical indexing on the ORE data base

  16. Information System on Occupational Exposure: Future Developments

    International Nuclear Information System (INIS)

    Jean-Yves Gagnon; Waturu Mizumachi; Brian Ahier; Ted Lazo; Khammar Mrabit

    2006-01-01

    In response to pressures from deregulation and from ageing of the global nuclear power plant fleet, radiation protection personnel have found that occupational exposures are best managed through proper job planning, implementation and review to ensure that exposures are 'as low as reasonably achievable'(ALARA). A prerequisite for applying the principle of optimisation to occupational radiation protection is the timely exchange of data and information on dose reduction methods. To facilitate this global approach to work management, the OECD Nuclear Energy Agency (Nea) launched the Information System on Occupational Exposure (I.S.O.E.) in 1992. The objective of I.S.O.E. is to provide a forum for radiation protection experts from both utilities and national regulatory authorities to discuss, promote and coordinate international cooperative undertakings for the radiological protection of workers at nuclear power plants.The I.S.O.E. programme offers a variety of products in the occupational exposure area, such as: the world largest database on occupational exposure from nuclear power plants, a yearly analysis of dose trends and an overview of current developments, through I.S.O.E. Annual Reports, detailed studies, analyses, and information on current issues in operational radiation protection, through I.S.O.E. Information Sheets, a system for rapid communication of radiation protection-related information, such as effective dose reduction approaches and implementation of work management principles. A forum for discussing occupational exposure management issues through I.S.O.E. workshops, symposia and newsletters. (N.C.)

  17. Infrared laser scattering system for plasma diagnostics

    Energy Technology Data Exchange (ETDEWEB)

    Muraoka, K; Hiraki, N; Kawasaki, S [Kyushu Univ., Fukuoka (Japan). Research Inst. for Applied Mechanics

    1975-05-01

    The possibility of observing the collective scattering of infrared laser light from plasmas is discussed in terms of the laser power requirement, the necessary optical system and the detector performance, and is shown to be feasible with the present day techniques to get the ion temperature by means of a CO/sub 2/ laser on theta pinch plasmas. Based on this estimate, the construction of the TEA CO/sub 2/ laser and the preparations of the optical components have been started and some preliminary results of these are described.

  18. Infrared laser scattering system for plasma diagnostics

    International Nuclear Information System (INIS)

    Muraoka, Katsunori; Hiraki, Naoji; Kawasaki, Shoji

    1975-01-01

    The possibility of observing the collective scattering of infrared laser light from plasmas is discussed in terms of the laser power requirement, the necessary optical system and the detector performance, and is shown to be feasible with the present day techniques to get the ion temperature by means of a CO 2 laser on theta pinch plasmas. Based on this estimate, the construction of the TEA CO 2 laser and the preparations of the optical components have been started and some preliminary results of these are described. (auth.)

  19. Plasma waves in hot relativistic beam-plasma systems: Pt. 1

    International Nuclear Information System (INIS)

    Magneville, A.

    1990-01-01

    Dispersion relations of plasma waves in a beam-plasma system are computed in the general case where the plasma and beam temperatures, and the velocity of the beam, may be relativistic. The two asymptotic temperature cases, and different contributions of plasma or beam particles to wave dispersion are considered. (author)

  20. Oxygen plasma treatment of HKUST-1 for porosity retention upon exposure to moisture.

    Science.gov (United States)

    Bae, Jaeyeon; Jung, Jin-Woo; Park, Hyo Yul; Cho, Chang-Hee; Park, Jinhee

    2017-11-07

    Despite their remarkable properties, metal-organic frameworks (MOFs) present vulnerable structures that are sensitive to moisture; therefore, their application to real field situations is challenging. Herein, an O 2 plasma technique was introduced as a new method for the activation and protection of porosity in HKUST-1. In an unprecedented manner, O 2 plasma-treated HKUST-1 retains its porosity after a long exposure to moisture as compared to pristine HKUST-1. Porosity retention was examined by N 2 adsorption/desorption measurements of non-activated HKUST-1 after exposure to moisture.

  1. In-situ real time measurements of net erosion rates of copper during hydrogen plasma exposure

    Science.gov (United States)

    Kesler, Leigh; Wright, Graham; Peterson, Ethan; Whyte, Dennis

    2013-10-01

    In order to properly understand the dynamics of net erosion/deposition in fusion reactors, such as tokamaks, a diagnostic measuring the real time rates of net erosion/deposition during plasma exposure is necessary. The DIONISOS experiment produces real time measurements of net erosion/deposition by using Rutherford backscattering spectroscopy (RBS) ion beam analysis simultaneously with plasma exposure from a helicon plasma source. This in-situ method improves on ex-situ weight loss measurements by allowing measurement of possible synergistic effects of high ion implantation rates and net erosion rate and by giving a real time response to changes in plasma parameters. Previous work has validated this new technique for measuring copper (Cu) erosion from helium (He) plasma ion bombardment. This technique is now extended to measure copper erosion due to deuterium and hydrogen plasma ion exposure. Targets used were a 1.5 μm Cu layer on an aluminum substrate. Cu layer thickness is tracked in real time using 1.2 MeV proton RBS. Measured erosion rates will be compared to results from literature and He erosion rates. Supported by US DoE award DE-SC00-02060.

  2. Production of molecules on a surface under plasma exposure: example of NO on pyrex

    International Nuclear Information System (INIS)

    Marinov, D; Guaitella, O; Rousseau, A; Ionikh, Y

    2010-01-01

    We propose a new experimental approach to the study of surface-catalysed nitric oxide production under plasma exposure. Stable nitrogen species are grafted to the surface of a pyrex discharge tube during N 2 plasma pretreatment. These species are trapped by surface active sites and on being exposed to O 2 plasma, they initiate the production of NO molecules, which are detected using tunable diode laser absorption spectroscopy. Supposing that nitrogen species are adsorbed N atoms, we estimate the initial surface coverage as [N ads ] = 3 x 10 13 cm -2 . This gives an assessment of the lower boundary of the density of surface active sites.

  3. Depleted uranium plasma reduction system study

    International Nuclear Information System (INIS)

    Rekemeyer, P.; Feizollahi, F.; Quapp, W.J.; Brown, B.W.

    1994-12-01

    A system life-cycle cost study was conducted of a preliminary design concept for a plasma reduction process for converting depleted uranium to uranium metal and anhydrous HF. The plasma-based process is expected to offer significant economic and environmental advantages over present technology. Depleted Uranium is currently stored in the form of solid UF 6 , of which approximately 575,000 metric tons is stored at three locations in the U.S. The proposed system is preconceptual in nature, but includes all necessary processing equipment and facilities to perform the process. The study has identified total processing cost of approximately $3.00/kg of UF 6 processed. Based on the results of this study, the development of a laboratory-scale system (1 kg/h throughput of UF6) is warranted. Further scaling of the process to pilot scale will be determined after laboratory testing is complete

  4. Plasma confinement system and methods for use

    Science.gov (United States)

    Jarboe, Thomas R.; Sutherland, Derek

    2017-09-05

    A plasma confinement system is provided that includes a confinement chamber that includes one or more enclosures of respective helicity injectors. The one or more enclosures are coupled to ports at an outer radius of the confinement chamber. The system further includes one or more conductive coils aligned substantially parallel to the one or more enclosures and a further set of one or more conductive coils respectively surrounding portions of the one or more enclosures. Currents may be provided to the sets of conductive coils to energize a gas within the confinement chamber into a plasma. Further, a heat-exchange system is provided that includes an inner wall, an intermediate wall, an outer wall, and pipe sections configured to carry coolant through cavities formed by the walls.

  5. Age dependent systemic exposure to inhaled salbutamol

    DEFF Research Database (Denmark)

    Bønnelykke, Klaus; Jespersen, Jakob Jessing; Bisgaard, Hans

    2007-01-01

    AIMS: To determine the effect of age on systemic exposure to inhaled salbutamol in children. METHODS: Fifty-eight asthmatic children, aged 3-16 years, inhaled 400 microg of salbutamol from a pressurized metered dose inhaler with spacer. The 20 min serum profile was analyzed. RESULTS: Prescribing...

  6. Plasma focus system: Design, construction and experiments

    International Nuclear Information System (INIS)

    Alacakir, A.; Akguen, Y.; Boeluekdemir, A. S.

    2007-01-01

    The aim of this work is to construct a compact experimental system for fusion research. The design, construction and experiments of the 3 kJ Mather type plasma focus machine is described. This machine is established for neutron yield and fast neutron radiography by D-D reaction which is given by D + D→ 3 He (0.82 MeV) + n (2.45 MeV) . Investigation of the geometry of plasma focus machine in the presence of high voltage drive and vacuum system setup is shown. 108 neutron per pulse and 200 kA peak current is obtained for many shots. Scintillator screen for fast neutron imaging, sensitive to 2.45 MeV neutrons, is also manufactured in our labs. Structural neutron shielding computations for safety is also completed

  7. Early Effect of High Dose of Ionizing Radiation Exposure on Plasma Lipids Profile and Liver Fatty Acids Composition in Rats

    International Nuclear Information System (INIS)

    Noaman, E.; Mansour, S.Z.; Ibrahim, N.K.

    2005-01-01

    The present study was conducted to analyze the effect of acute gamma-irradiation on rats at supralethal doses of 20 Gy to determine the synthesis and amounts of free fatty acids, neutral lipids and phospholipids of plasma and liver after 24 and 48 h of gamma-irradiation. Male Wistar rats weighing 120+- 20 g were exposed to 20 Gy of gamma radiation (dose rate of 0.59 Gy/min). Exposure of rats to ionizing radiation resulted in significant alterations in the assayed parameters indicating lipid metabolism disturbance. Plasma cholesterol and phospholipid levels increased up to 71.3 and 71.5 %, respectively, after 24 h from radiation exposure and then returned to 28 and 27 % change in-compare with control values after 48 h post-irradiation. Plasma triacylglycerol concentrations increased concomitantly with irradiation, but their values are less high than cholesterol and phospholipid levels recording significant changes at 19 and 9 % comparing with control rats. Lipid peroxidation measured as MDA recorded significant elevation after 24 and 48 h post irradiation. It was shown that the synthesis of free fatty acids, cholesterol, cholesterol ethers and phospholipids was activated 48 h after irradiation at 20 Gy. The amount of free fatty acids of the rat liver decreased at 20 Gy exposures. This is assumed to be a result of the radioresistance to some degree in the system of free fatty acid synthesis of the rat to the gamma-irradiation in the lethal doses

  8. Effect of sub-acute exposure to bonny light crude oil on plasma ...

    African Journals Online (AJOL)

    Effect of sub-acute exposure to bonny light crude oil on plasma biochemistry and liver histopathology of albino rat. Christopher Efe Oritseweyinmi Ikanone, Oluseyi Adeboye Akinloye, Regina Ngozi Ugbaja, Samuel Olatunbosun Omotainse, Olusola Lawrence Ajayi, Tolumide Michael Shopein ...

  9. Toxicity and Immunogenicity in Murine Melanoma following Exposure to Physical Plasma-Derived Oxidants

    Directory of Open Access Journals (Sweden)

    Sander Bekeschus

    2017-01-01

    Full Text Available Metastatic melanoma is an aggressive and deadly disease. Therapeutic advance has been achieved by antitumor chemo- and radiotherapy. These modalities involve the generation of reactive oxygen and nitrogen species, affecting cellular viability, migration, and immunogenicity. Such species are also created by cold physical plasma, an ionized gas capable of redox modulating cells and tissues without thermal damage. Cold plasma has been suggested for anticancer therapy. Here, melanoma cell toxicity, motility, and immunogenicity of murine metastatic melanoma cells were investigated following plasma exposure in vitro. Cells were oxidized by plasma, leading to decreased metabolic activity and cell death. Moreover, plasma decelerated melanoma cell growth, viability, and cell cycling. This was accompanied by increased cellular stiffness and upregulation of zonula occludens 1 protein in the cell membrane. Importantly, expression levels of immunogenic cell surface molecules such as major histocompatibility complex I, calreticulin, and melanocortin receptor 1 were significantly increased in response to plasma. Finally, plasma treatment significantly decreased the release of vascular endothelial growth factor, a molecule with importance in angiogenesis. Altogether, these results suggest beneficial toxicity of cold plasma in murine melanomas with a concomitant immunogenicity of potential interest in oncology.

  10. Plasma exposure behavior of re-deposited tungsten on structural materials of fusion reactors

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Yu-Ping; Wang, Jing [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei 230031 (China); Science Island Branch of Graduate School, University of Science & Technology of China, Hefei 230031 (China); Zhou, Hai-Shan, E-mail: haishanzhou@ipp.ac.cn [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei 230031 (China); Liu, Feng [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei 230031 (China); Li, Zeng-De [General Research Institute for Nonferrous Metals, Beijing 100088 (China); Li, Xiao-Chun; Lu, Tao [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei 230031 (China); Liu, Hao-Dong [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei 230031 (China); Science Island Branch of Graduate School, University of Science & Technology of China, Hefei 230031 (China); Ding, Fang; Mao, Hong-Min; Zhao, Ming-Zhong [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei 230031 (China); Lin, Chen-Guang [General Research Institute for Nonferrous Metals, Beijing 100088 (China); Luo, Guang-Nan [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei 230031 (China); Science Island Branch of Graduate School, University of Science & Technology of China, Hefei 230031 (China); Hefei Center for Physical Science and Technology, Hefei 230031 (China); Hefei Science Center of Chinese Academy of Science, Hefei 230027 (China)

    2017-05-15

    To evaluate the effects of re-deposited tungsten (W) on the surface modification and hydrogen isotope retention behavior of fusion structural materials, the plasma exposure behavior of re-deposited W samples prepared by magnetron sputtering on the F82H steel, the V-5Cr-5Ti alloy as well as bare substrate samples was investigated. All the samples were exposed to 367 shots of deuterium plasmas in the 2015 spring EAST campaign. After the plasma exposure, large area of W layer was exfoliated, while big blisters were found at the interface between the remaining W layer and the substrate materials. The deuterium retention behavior of the samples with re-deposited W layer was characterized by thermal desorption spectroscopy and compared with the bare substrate samples.

  11. Effects of plasma and vacuum-ultraviolet exposure on the mechanical properties of low-k porous organosilicate glass

    Science.gov (United States)

    X. Guo; J.E. Jakes; S. Banna; Y. Nishi; J.L. Shohet

    2014-01-01

    The effects of plasma exposure and vacuum-ultraviolet (VUV) irradiation on the mechanical properties of low-k porous organosilicate glass (SiCOH) dielectric films were investigated. Nanoindentation measurements were made on SiCOH films before and after exposure to an electron-cyclotron-resonance plasma or a monochromatic synchrotron VUV beam, to determine the changes...

  12. The Effect of Plasma Exposure on Tail Regeneration of Tadpoles Xenopus Laevis

    Science.gov (United States)

    June, Joyce; Rivie, Adonis; Ezuduemoih, Raphael; Menon, Jaishri; Martus, Kevin

    2014-03-01

    Wound healing requires a balanced combination of nutrients and growth factors for healing and tissue regeneration. The effect of plasma exposure on tail regeneration of tadpoles, Xenopus laevis is investigated. The exposure of the wound to the helium plasma immediately followed the amputation of 40% of the tail. Amputation of the tail initiates regeneration of spinal cord, muscle, notochord, skin and connective tissues. By 24 h, the wound was covered by wound epithelium and blastema was formed by day 5. There was increased angiogenesis in plasma exposed tail regenerate compared to the control following 5 d post amputation. Observed was an increase in NO production in the regenerate of plasma exposed tadpoles was derived from increased activity of nNOS and iNOS. Western blot analysis for vascular endothelial growth factor showed stronger bands for the protein in amputated tadpoles of both the groups. Analysis of the composition and characteristics of the plasma using optical emission spectroscopy indicates excited state species consisting of N2, N2+,and OH is present in the plasma. This study was supported, in part, by the NSF Grant 1040108.

  13. Investigation of the helicon discharge plasma parameters in a hybrid RF plasma system

    International Nuclear Information System (INIS)

    Aleksandrov, A. F.; Petrov, A. K.; Vavilin, K. V.; Kralkina, E. A.; Neklyudova, P. A.; Nikonov, A. M.; Pavlov, V. B.; Ayrapetov, A. A.; Odinokov, V. V.; Sologub, V. A.; Pavlov, G. Ya.

    2016-01-01

    Results of an experimental study of the helicon discharge plasma parameters in a prototype of a hybrid RF plasma system equipped with a solenoidal antenna are described. It is shown that an increase in the external magnetic field leads to the formation of a plasma column and a shift of the maximum ion current along the discharge axis toward the bottom flange of the system. The shape of the plasma column can be controlled via varying the configuration of the magnetic field.

  14. Investigation of the helicon discharge plasma parameters in a hybrid RF plasma system

    Energy Technology Data Exchange (ETDEWEB)

    Aleksandrov, A. F.; Petrov, A. K., E-mail: alpetrov57@gmail.com; Vavilin, K. V.; Kralkina, E. A.; Neklyudova, P. A.; Nikonov, A. M.; Pavlov, V. B. [Moscow State University, Faculty of Physics (Russian Federation); Ayrapetov, A. A.; Odinokov, V. V.; Sologub, V. A.; Pavlov, G. Ya. [Research Institute of Precision Engineering (Russian Federation)

    2016-03-15

    Results of an experimental study of the helicon discharge plasma parameters in a prototype of a hybrid RF plasma system equipped with a solenoidal antenna are described. It is shown that an increase in the external magnetic field leads to the formation of a plasma column and a shift of the maximum ion current along the discharge axis toward the bottom flange of the system. The shape of the plasma column can be controlled via varying the configuration of the magnetic field.

  15. Exposure to DEHP decreased four fatty acid levels in plasma of prepartum mice

    International Nuclear Information System (INIS)

    Nakashima, Ryosuke; Hayashi, Yumi; Khalequzzaman, Md.; Jia, Xiaofang; Wang, Dong; Naito, Hisao; Ito, Yuki; Kamijima, Michihiro; Gonzalez, Frank J.; Nakajima, Tamie

    2013-01-01

    Maternal exposure to di(2-ethylhexyl) phthalate (DEHP) decreased the plasma triglyceride in prepartum mice. To identify the fatty acid (FA) species involved and to understand the underlying mechanisms, pregnant Sv/129 wild-type (mPPARα), peroxisome proliferator-activated receptor α-null (Pparα-null) and humanized PPARα (hPPARα) mice were treated with diets containing 0%, 0.01%, 0.05% or 0.1% DEHP. Dams were dissected on gestational day 18 together with fetuses, and on postnatal day 2 together with newborns. n-3/n-6 polyunsaturated, saturated, and monounsaturated FAs in maternal plasma and in liver of wild-type offspring, and representative enzymes for FA desaturation and elongation in maternal liver, were measured. The plasma levels of linoleic acid, α-linolenic acid, palmitic acid and oleic acid were higher in the pregnant control mPPARa mice than in Ppara-null and hPPARa mice. DEHP exposure significantly decreased the levels of these four FAs only in pregnant mPPARα mice. Plasma levels of many FAs were higher in pregnant mice than in postpartum ones in a genotype-independent manner, while it was lower in the livers of fetuses than pups. DEHP exposure slightly increased hepatic arachidonic acid, α-linolenic acid, palmitoleic acid and oleic acid in fetuses, but not in pups. However, DEHP exposure did not clearly influence FA desaturase 1 and 2 nor elongase 2 and 5 expressions in the liver of all maternal mice. Taken together, the levels of plasma four FAs with shorter carbon chains were higher in pregnant mPPARα mice than in other genotypes, and DEHP exposure decreased these specific FA concentrations only in mPPARα mice, similarly to triglyceride levels

  16. Valency and type conversion in CuInSe2 with H2 plasma exposure: A photoemission investigation

    International Nuclear Information System (INIS)

    Nelson, A.J.; Frigo, S.P.; Rosenberg, R.

    1993-01-01

    The effect of H 2 plasma exposure on CuInSe 2 was studied by synchrotron radiation soft-x-ray photoemission spectroscopy. The low-power H 2 plasma was generated with a commercial electron cyclotron resonance plasma source using pure H 2 with the plasma exposure being performed at 200 degree C. In situ photoemission measurements were acquired after each plasma exposure in order to observe changes in the valence-band electronic structure as well as changes in the In 4d and Se 3d core lines. The results were correlated in order to relate changes in surface chemistry to the electronic structure. These measurements indicate that the H 2 plasma exposure type converts the CuInSe 2 surface to an n-type surface as well as converting the In +3 valency state to an In +1 valency state

  17. Development of the Plasma Movie Database System for JT-60

    International Nuclear Information System (INIS)

    Sueoka, M.; Kawamata, Y.; Kurihara, K.

    2006-01-01

    A plasma movie is generally expected as one of the most efficient methods to know what plasma discharge has been conducted in the experiment. On this motivation we have developed and operated a real-time plasma shape visualization system over ten years. The current plasma movie is composed of (1) video camera picture looking at a plasma, (2) computer graphic (CG) picture, and (3) magnetic probe signal as a sound channel. (1) The plasma video movie is provided by a standard video camera, equipped at the viewing port of the vacuum vessel looking at a plasma poloidal cross section. (2) A plasma shape CG movie is provided by the plasma shape visualization system, which calculates the plasma shape in real-time using the CCS method [Kurihara, K., Fusion Engineering and Design, 51-52, 1049 (2000)]. Thirty snap-shot pictures per second are drawn by the graphic processor. (3) A sound in the movie is a raw signal of magnetic pick up coil. This sound reflects plasma rotation frequency which shows smooth high tone sound seems to mean a good plasma. In order to use this movie efficiently, we have developed a new system having the following functions: (a) To store a plasma movie in the movie database system automatically combined with the plasma shape CG and the sound according to a discharge sequence. (b) To make a plasma movie be available (downloadable) for experiment data analyses at the Web-site. The plasma movie capture system receives the timing signal according to the JT-60 discharge sequence, and starts to record a plasma movie automatically. The movie is stored in a format of MPEG2 in the RAID-disk. In addition, the plasma movie capture system transfers a movie file in a MPEG4 format to the plasma movie web-server at the same time. In response to the user's request the plasma movie web-server transfers a stored movie data immediately. The movie data amount for the MPEG2 format is about 50 Mbyte/shot (65 s discharge), and that for the MPEG4 format is about 7 Mbyte

  18. Surface morphology changes to tungsten under exposure to He ions from an electron cyclotron resonance plasma source

    Science.gov (United States)

    Donovan, David; Maan, Anurag; Duran, Jonah; Buchenauer, Dean; Whaley, Josh

    2015-11-01

    Exposure of tungsten to low energy (ALMT ITER grade tungsten samples. A similar He plasma exposure stage has now been developed at the University of Tennessee-Knoxville with an improved compact ECR plasma source. Status of the new UTK exposure stage will be discussed as well as planned experiments and new material characterization techniques (EBSD, GIXRD). Work supported by US DOE Contract DE-AC04-94AL85000 and the PSI Science Center.

  19. Is plasma β-glucuronidase a novel human biomarker for monitoring anticholinesterase pesticides exposure? A Malaysian experience

    International Nuclear Information System (INIS)

    Inayat-Hussain, Salmaan H.; Lubis, Syarif Husin; Sakian, Noor Ibrahim Mohamed; Ghazali, Ahmad Rohi; Ali, Noor Suhailah; El Sersi, Magdi; Toong, Lee Mun; Zainal, Awang Mat; Hashim, Suhaimi; Ghazali, Mohd Shariman; Saidin, Mohd Nazri; Rahman, Ab Razak Ab; Rafaai, Mohd Jamil Mohd; Omar, Sollahudin; Rapiai, Rafiah; Othman, Radziah; Chan, Lee Tiong; Johari, Amran; Soon, Wong Hing; Salleh, Abdul Rahim; Satoh, Tetsuo

    2007-01-01

    A cross-sectional study was conducted to investigate the effects of acute and chronic pesticide exposure on the plasma β-glucuronidase enzyme activity among five patients of acute pesticide poisoning in Tengku Ampuan Rahimah Hospital, Klang, 230 farmers in the MADA area, Kedah and 49 fishermen in Setiu, Terengganu. The duration of pesticide exposure among the patients was unknown, but the plasma samples from patients were collected on day one in the hospital. The duration of pesticide exposure among the farmers was between 1 and 45 years. The β-glucuronidase activity was compared with plasma cholinesterase activity in the same individual. The plasma cholinesterase activity was measured using Cholinesterase (PTC) Reagent set kit (Teco Diagnostics, UK) based on colorimetric method, while the plasma β-glucuronidase activity was measured fluorometrically based on β-glucuronidase assay. The plasma cholinesterase activity was significantly reduced (p 0.05). The plasma β-glucuronidase activity among the farmers was significantly elevated (p 0.05). The plasma cholinesterase activity was positively correlated with the plasma β-glucuronidase activity among the farmers (r = 0.205, p 0.05). Thus, plasma β-glucuronidase enzyme activity can be measured as a biomarker for the chronic exposure of pesticide. However, further studies need to be performed to confirm whether plasma β-glucuronidase can be a sensitive biomarker for anticholinesterase pesticide poisoning

  20. TFTR power conversion and plasma feedback systems

    International Nuclear Information System (INIS)

    Neumeyer, C.

    1985-01-01

    Major components of the Tokamak Fusion Test Reactor (TFTR) power conversion system include 39 thyristor rectifier power supplies, 12 energy storage capacitor banks, and 6 ohmic heating interrupters. These components are connected in various series/parallel configurations to provide controlled pulses of current to the Toroidal Field (TF), Ohmic Heating (OH), Equilibrium (vertical) Field (EF), and Horizontal Field (HF) magnet coil systems. Real-time control of the power conversion system is accomplished by a centralized dedicated computer; local control is minimal. Power supply firing angles, capacitor bank charge and discharge commands, interrupter commands, etc., are all determined and issued by the central computer. Plasma Position and Current Control (PPCC) reference signals to power conversion (OH, EF, HF) are determined by separate analog electronics but invoked through the power conversion computer. Real-time fault sensing of plasma parameters, gas injection, neutral beams, etc., are monitored by a separate Discharge Fault System (DFS) but routed through the power conversion computer for pre-programmed shutdown response

  1. MFTF plasma diagnostics data acquisition system

    International Nuclear Information System (INIS)

    Davis, G.E.; Coffield, F.E.

    1979-01-01

    The initial goal of the Data Acquisition System (DAS) is to control 11 instruments chosen as the startup diagnostic set and to collect, process, and display the data that these instruments produce. These instruments are described in a paper by Stan Thomas, et. al. entitled ''MFTF Plasma Diagnostics System.'' The DAS must be modular and flexible enough to allow upgrades in the quantity of data taken by an instrument, and also to allow new instruments to be added to the system. This is particularly necessary to support a research project where needs and requirements may change rapidly as a result of experimental findings. Typically, the startup configuration of the diagnostic instruments will contain only a fraction of the planned detectors, and produce approximately one half the data that the expanded version is designed to generate. Expansion of the system will occur in fiscal year 1982

  2. Atmospheric pressure microwave plasma system with ring waveguide

    International Nuclear Information System (INIS)

    Liu Liang; Zhang Guixin; Zhu Zhijie; Luo Chengmu

    2007-01-01

    Some scientists used waveguide as the cavity to produce a plasma jet, while large volume microwave plasma was relatively hard to get in atmospheric pressure. However, a few research institutes have already developed devices to generate large volume of atmospheric pressure microwave plasma, such as CYRANNUS and SLAN series, which can be widely applied. In this paper, present a microwave plasma system with ring waveguide to excite large volume of atmospheric pressure microwave plasma, plot curves on theoretical disruption electric field of some working gases, emulate the cavity through software, measure the power density to validate and show the appearance of microwave plasma. At present, large volume of argon and helium plasma have already been generated steadily by atmospheric pressure microwave plasma system. This research can build a theoretical basis of microwave plasma excitation under atmospheric pressure and will be useful in study of the device. (authors)

  3. DAQ system for low density plasma parameters measurement

    International Nuclear Information System (INIS)

    Joshi, Rashmi S.; Gupta, Suryakant B.

    2015-01-01

    In various cases where low density plasmas (number density ranges from 1E4 to 1E6 cm -3 ) exist for example, basic plasma studies or LEO space environment measurement of plasma parameters becomes very critical. Conventional tip (cylindrical) Langmuir probes often result into unstable measurements in such lower density plasma. Due to larger surface area, a spherical Langmuir probe is used to measure such lower plasma densities. Applying a sweep voltage signal to the probe and measuring current values corresponding to these voltages gives V-I characteristics of plasma which can be plotted on a digital storage oscilloscope. This plot is analyzed for calculating various plasma parameters. The aim of this paper is to measure plasma parameters using a spherical Langmuir probe and indigenously developed DAQ system. DAQ system consists of Keithley source-meter and a host system connected by a GPIB interface. An online plasma parameter diagnostic system is developed for measuring plasma properties for non-thermal plasma in vacuum. An algorithm is developed using LabVIEW platform. V-I characteristics of plasma are plotted with respect to different filament current values and different locations of Langmuir probe with reference to plasma source. V-I characteristics is also plotted for forward and reverse voltage sweep generated programmatically from the source meter. (author)

  4. GPU Nuclear Corporation's radiation exposure management system

    International Nuclear Information System (INIS)

    Slobodien, M.J.; Bovino, A.A.; Perry, O.R.; Hildebrand, J.E.

    1984-01-01

    GPU Nuclear Corporation has developed a central main frame (IBM 3081) based radiation exposure management system which provides real time and batch transactions for three separate reactor facilities. The structure and function of the data base are discussed. The system's main features include real time on-line radiation work permit generation and personnel exposure tracking; dose accountability as a function of system and component, job type, worker classification, and work location; and personnel dosemeter (TLD and self-reading pocket dosemeters) data processing. The system also carries the qualifications of all radiation workers including RWP training, respiratory protection training, results of respirator fit tests and medical exams. A warning system is used to prevent non-qualified persons from entering controlled areas. The main frame system is interfaced with a variety of mini and micro computer systems for dosemetry, statistical and graphics applications. These are discussed. Some unique dosemetry features which are discussed include assessment of dose for up to 140 parts of the body with dose evaluations at 7,300 and 1000 mg/cm 2 for each part, tracking of MPC hours on a 7 day rolling schedule; automatic pairing of TLD and self-reading pocket dosemeter values, creation and updating of NRC Forms 4 and 5, generation of NRC required 20.407 and Reg Guide 1.16 reports. As of July 1983, over 20 remote on-line stations were in use with plans to add 20-30 more by May 1984. The system provides response times for on-line activities of 2-7 seconds and 23 1/2 hours per day ''up time''. Examples of the various on-line and batch transactions are described

  5. Characterization of a monodispersed aerosol exposure system for beagle dogs

    International Nuclear Information System (INIS)

    Cannon, W.C.; Herring, J.P.; Craig, D.K.

    1978-01-01

    A monodispersed aerosol exposure system for dogs is described and data are presented on aerosol depositions in the exposure system which could affect the aerosol presented to the animals by reducing the concentration and changing the particle size distribution

  6. Plasma exchange in progressive systemic sclerosis

    Directory of Open Access Journals (Sweden)

    Mohammad Bagher Owlia

    2015-10-01

    Full Text Available Systemic sclerosis (SSc is an autoimmune systemic disease of unknown etiology. Present treatment modalities have limited impact on clinical/ laboratory outcomes. For the first time in our center, we used plasma exchange (PEx in a rather young woman with recent onset but progressive SSc. She is a 39-year-old woman with a recent history of skin stiffness, Raynaud’s phenomenon, nail fold capillary changes and newly diagnosis of SSc presented to us due to worsening her clinical symptoms even after initiation of routine remedies such as low dose oral prednisolone, Ca-channel blockers, azathioprine and pentoxyfylline. After obtaining written consent, interdisciplinary discussion with experts in this field and agreement we started a series of plasma exchange with FFP replacement for her. A dramatic clinical response was observed in respect to Raynaud’s phenomenon, skin stiffness, tendon rub after three sessions of PEx. Her modified Rodnan skin score (MRSS dropped from 36 (before commencement of therapy to 28 in day 4 and 18 in day 20 after 15 sessions of PEx. In conclusion PEx could significantly modify the course of SSc as observed in our case study. Elimination of culprit immune mediators/cytokines/autoantibodies could be the possible mechanism of action of PEx. 

  7. Architecture of WEST plasma control system

    International Nuclear Information System (INIS)

    Ravenel, N.; Nouailletas, R.; Barana, O.; Brémond, S.; Moreau, P.; Guillerminet, B.; Balme, S.; Allegretti, L.; Mannori, S.

    2014-01-01

    To operate advanced plasma scenario (long pulse with high stored energy) in present and future tokamak devices under safe operation conditions, the control requirements of the plasma control system (PCS) leads to the development of advanced feedback control and real time handling exceptions. To develop these controllers and these exceptions handling strategies, a project aiming at setting up a flight simulator has started at CEA in 2009. Now, the new WEST (W Environment in Steady-state Tokamak) project deals with modifying Tore Supra into an ITER-like divertor tokamak. This upgrade impacts a lot of systems including Tore Supra PCS and is the opportunity to improve the current PCS architecture to implement the previous works and to fulfill the needs of modern tokamak operation. This paper is dealing with the description of the architecture of WEST PCS. Firstly, the requirements will be presented including the needs of new concepts (segments configuration, alternative (or backup) scenario, …). Then, the conceptual design of the PCS will be described including the main components and their functions. The third part will be dedicated to the proposal RT framework and to the technologies that we have to implement to reach the requirements

  8. Railgun system using a laser-induced plasma armature

    International Nuclear Information System (INIS)

    Onozuka, M.; Oda, Y.; Azuma, K.

    1996-01-01

    Development of an electromagnetic railgun system that utilizes a laser-induced plasma armature formation has been conducted to investigate the application of the railgun system for high-speed pellet injection into fusion plasmas. Using the laser-induced plasma formation technique, the required breakdown voltage was reduced by one-tenth compared with that for the spark-discharged plasma. The railgun system successfully accelerated the laser-induced plasma armature by an electromagnetic force that accelerated the pellet. The highest velocity of the solid hydrogen pellets, obtained so far, was 2.6 km/sec using a 2m-long railgun. copyright 1996 American Institute of Physics

  9. Railgun system using a laser-induced plasma armature

    Science.gov (United States)

    Onozuka, Masanori; Oda, Yasushi; Azuma, Kingo

    1996-05-01

    Development of an electromagnetic railgun system that utilizes a laser-induced plasma armature formation has been conducted to investigate the application of the railgun system for high-speed pellet injection into fusion plasmas. Using the laser-induced plasma formation technique, the required breakdown voltage was reduced by one-tenth compared with that for the spark-discharged plasma. The railgun system successfully accelerated the laser-induced plasma armature by an electromagnetic force that accelerated the pellet. The highest velocity of the solid hydrogen pellets, obtained so far, was 2.6 km/sec using a 2m-long railgun.

  10. Railgun system using a laser-induced plasma armature

    Energy Technology Data Exchange (ETDEWEB)

    Onozuka, M.; Oda, Y.; Azuma, K. [Mitsubishi Heavy Industries, Ltd., 3-3-1, Minatomirai, Nishi-ku, Yokohama 220-84 (Japan)

    1996-05-01

    Development of an electromagnetic railgun system that utilizes a laser-induced plasma armature formation has been conducted to investigate the application of the railgun system for high-speed pellet injection into fusion plasmas. Using the laser-induced plasma formation technique, the required breakdown voltage was reduced by one-tenth compared with that for the spark-discharged plasma. The railgun system successfully accelerated the laser-induced plasma armature by an electromagnetic force that accelerated the pellet. The highest velocity of the solid hydrogen pellets, obtained so far, was 2.6 km/sec using a 2m-long railgun. {copyright} {ital 1996 American Institute of Physics.}

  11. Modelling deuterium release from tungsten after high flux high temperature deuterium plasma exposure

    Energy Technology Data Exchange (ETDEWEB)

    Grigorev, Petr, E-mail: grigorievpit@gmail.com [SCK-CEN, Nuclear Materials Science Institute, Boeretang 200, Mol, 2400 (Belgium); Ghent University, Applied Physics EA17 FUSION-DC, St. Pietersnieuwstraat, 41 B4, B-9000, Gent (Belgium); Department of Experimental Nuclear Physics K-89, Institute of Physics, Nanotechnologies, and Telecommunications, Peter the Great St. Petersburg Polytechnic University, St. Petersburg (Russian Federation); Matveev, Dmitry [Institute of Energy and Climate Research – Plasma Physics, Forschungszentrum Jülich GmbH, Trilateral Euregio Cluster, 52425, Jülich (Germany); Bakaeva, Anastasiia [SCK-CEN, Nuclear Materials Science Institute, Boeretang 200, Mol, 2400 (Belgium); Department of Applied Physics, Ghent University (Belgium); Terentyev, Dmitry [SCK-CEN, Nuclear Materials Science Institute, Boeretang 200, Mol, 2400 (Belgium); Zhurkin, Evgeny E. [Department of Experimental Nuclear Physics K-89, Institute of Physics, Nanotechnologies, and Telecommunications, Peter the Great St. Petersburg Polytechnic University, St. Petersburg (Russian Federation); Van Oost, Guido [Ghent University, Applied Physics EA17 FUSION-DC, St. Pietersnieuwstraat, 41 B4, B-9000, Gent (Belgium); Noterdaeme, Jean-Marie [Ghent University, Applied Physics EA17 FUSION-DC, St. Pietersnieuwstraat, 41 B4, B-9000, Gent (Belgium); Max-Planck-Institut für Plasmaphysik, Garching (Germany)

    2016-12-01

    Tungsten is a primary candidate for plasma facing materials for future fusion devices. An important safety concern in the design of plasma facing components is the retention of hydrogen isotopes. Available experimental data is vast and scattered, and a consistent physical model of retention of hydrogen isotopes in tungsten is still missing. In this work we propose a model of non-equilibrium hydrogen isotopes trapping under fusion relevant plasma exposure conditions. The model is coupled to a diffusion-trapping simulation tool and is used to interpret recent experiments involving high plasma flux exposures. From the computational analysis performed, it is concluded that high flux high temperature exposures (T = 1000 K, flux = 10{sup 24} D/m{sup 2}/s and fluence of 10{sup 26} D/m{sup 2}) result in generation of sub-surface damage and bulk diffusion, so that the retention is driven by both sub-surface plasma-induced defects (bubbles) and trapping at natural defects. On the basis of the non-equilibrium trapping model we have estimated the amount of H stored in the sub-surface region to be ∼10{sup −5} at{sup −1}, while the bulk retention is about 4 × 10{sup −7} at{sup −1}, calculated by assuming the sub-surface layer thickness of about 10 μm and adjusting the trap concentration to comply with the experimental results for the integral retention.

  12. Mechanical properties of tungsten following rhenium ion and helium plasma exposure

    Directory of Open Access Journals (Sweden)

    C.S. Corr

    2017-08-01

    Full Text Available Mechanical properties of Tungsten (W samples irradiated with 2 MeV Rhenium (Re ions and helium (He plasma were investigated using nanoindentation. It was found that there was an increase in hardness for all samples following separate irradiation with both Re ion and He plasma. A slight increase in hardness was obtained for combined exposures. A comparable increase in hardness was observed for a pure He plasma with a sample temperature of 473 K and 1273 K. Optical interferometry was employed to compare surface modification of the samples. Grazing incidence small angle x-ray scattering confirmed He nano-bubble formation of approximately 1 nm diameter in the higher temperature sample, which was not observed with samples at the lower temperatures.

  13. Plasma Discharge Process in a Pulsed Diaphragm Discharge System

    Science.gov (United States)

    Duan, Jianjin; Hu, Jue; Zhang, Chao; Wen, Yuanbin; Meng, Yuedong; Zhang, Chengxu

    2014-12-01

    As one of the most important steps in wastewater treatment, limited study on plasma discharge process is a key challenge in the development of plasma applications. In this study, we focus on the plasma discharge process of a pulsed diaphragm discharge system. According to the analysis, the pulsed diaphragm discharge proceeds in seven stages: (1) Joule heating and heat exchange stage; (2) nucleated site formation; (3) plasma generation (initiation of the breakdown stage); (4) avalanche growth and plasma expansion; (5) plasma contraction; (6) termination of the plasma discharge; and (7) heat exchange stage. From this analysis, a critical voltage criterion for breakdown is obtained. We anticipate this finding will provide guidance for a better application of plasma discharges, especially diaphragm plasma discharges.

  14. Double plasma system with inductively coupled source plasma and quasi-quiescent target plasma

    International Nuclear Information System (INIS)

    Massi, M.; Maciel, H.S.

    1995-01-01

    Cold plasmas have successfully been used in the plasma-assisted material processing industry. An understanding of the physicochemical mechanisms involved in the plasma-surface interaction is needed for a proper description of deposition and etching processes at material surfaces. Since these mechanisms are dependent on the plasma properties, the development of diagnostic techniques is strongly desirable for determination of the plasma parameters as well as the characterization of the electromagnetic behaviour of the discharge. In this work a dual discharge chamber, was specially designed to study the deposition of thin films via plasma polymerization process. In the Pyrex chamber an inductively coupled plasma can be excited either in the diffuse low density E-mode or in the high density H-mode. This plasma diffuses into the cylindrical stainless steel chamber which is covered with permanent magnets to produce a multidipole magnetic field configuration at the surface. By that means a double plasma is established consisting of a RF source plasma coupled to a quasi-quiescent target plasma. The preliminary results presented here refer to measurements of the profiles of plasma parameters along the central axis of the double plasma apparatus. Additionally a spectrum analysis performed by means of a Rogowski coil probe immersed into the source plasma is also presented. The discharge is made in argon with pressure varying from 10 -2 to 1 torr, and the rf from 10 to 150 W

  15. Observation of bifurcation phenomena in an electron beam plasma system

    International Nuclear Information System (INIS)

    Hayashi, N.; Tanaka, M.; Shinohara, S.; Kawai, Y.

    1995-01-01

    When an electron beam is injected into a plasma, unstable waves are excited spontaneously near the electron plasma frequency f pe by the electron beam plasma instability. The experiment on subharmonics in an electron beam plasma system was performed with a glow discharge tube. The bifurcation of unstable waves with the electron plasma frequency f pe and 1/2 f pe was observed using a double-plasma device. Furthermore, the period doubling route to chaos around the ion plasma frequency in an electron beam plasma system was reported. However, the physical mechanism of bifurcation phenomena in an electron beam plasma system has not been clarified so far. We have studied nonlinear behaviors of the electron beam plasma instability. It was found that there are some cases: the fundamental unstable waves and subharmonics of 2 period are excited by the electron beam plasma instability, the fundamental unstable waves and subharmonics of 3 period are excited. In this paper, we measured the energy distribution functions of electrons and the dispersion relation of test waves in order to examine the physical mechanism of bifurcation phenomena in an electron beam plasma system

  16. Design and development of a LIBS system on linear plasma device PSI-2 for in situ real-time diagnostics of plasma-facing materials

    Directory of Open Access Journals (Sweden)

    X. Jiang

    2017-08-01

    Full Text Available Laser induced breakdown spectroscopy (LIBS is a strong candidate for detecting and monitoring the H/D/T content on the surface of plasma facing components (PFCs due to its capability of fast direct in situ measurement in extreme environment (e.g., vacuum, magnetic field, long distance, complex geometry. To study the feasibilities and encounter the challenges of LIBS on plasma devices, a LIBS system has been set up on the linear plasma device PSI-2. A number of key parameters including laser energy, the influence of magnetic field and the persistence of laser induced plasma are studied. Real-time measurements of deuterium outgassing on tungsten samples exposed to deuterium plasma of 1025 D/m2 are performed in the first 40–130 min after plasma exposure. The experimental results are compared to the calculations in the literature.

  17. Development of the plasma movie database system in JT-60

    International Nuclear Information System (INIS)

    Sueoka, Michiharu; Kawamata, Yoichi; Kurihara, Kenichi; Seki, Akiyuki

    2008-03-01

    A plasma movie is generally expected as one of the most efficient methods to know what plasma discharge has been conducted in the experiment. The JT-60 plasma movie is composed of video camera picture looking at a plasma, computer graphics (CG) picture, and magnetic probe signal as a sound channel. In order to use this movie efficiently, we have developed a new system having the following functions: (a) To store a plasma movie in the movie database system automatically combined with the plasma shape CG and the sound according to a discharge sequence. (b) To make a plasma movie is available (downloadable) for experiment data analyses at the Web-site. Especially, this system aimed at minimizing the development cost, and it tried to develop the real-time plasma shape visualization system (RVS) without any operating system (OS) customized for real-time use. As a result, this system succeeded in working under Windows XP. This report deals with the technical details of the plasma movie database system and the real-time plasma shape visualization system. (author)

  18. Amorphous nanosilicas induce consumptive coagulopathy after systemic exposure

    International Nuclear Information System (INIS)

    Nabeshi, Hiromi; Yoshikawa, Tomoaki; Matsuyama, Keigo; Nakazato, Yasutaro; Arimori, Akihiro; Isobe, Masaaki; Tochigi, Saeko; Kondoh, Sayuri; Hirai, Toshiro; Akase, Takanori; Yamashita, Takuya; Yamashita, Kohei; Yoshida, Tokuyuki; Itoh, Norio; Nagano, Kazuya; Abe, Yasuhiro; Yoshioka, Yasuo; Kamada, Haruhiko; Imazawa, Takayoshi; Kondoh, Masuo

    2012-01-01

    We previously reported that well-dispersed amorphous nanosilicas with particle size 70 nm (nSP70) penetrate skin and produce systemic exposure after topical application. These findings underscore the need to examine biological effects after systemic exposure to nanosilicas. The present study was designed to examine the biological effects. BALB/c mice were intravenously injected with amorphous nanosilicas of sizes 70, 100, 300, 1000 nm and then assessed for survival, blood biochemistry, and coagulation. As a result, injection of nSP70 caused fatal toxicity, liver damage, and platelet depletion, suggesting that nSP70 caused consumptive coagulopathy. Additionally, nSP70 exerts procoagulant activity in vitro associated with an increase in specific surface area, which increases as diameter reduces. In contrast, nSP70-mediated procoagulant activity was absent in factor XII-deficient plasma. Collectively, we revealed that interaction between nSP70 and intrinsic coagulation factors such as factor XII, were deeply related to nSP70-induced harmful effects. In other words, it is suggested that if interaction between nSP70 and coagulation factors can be suppressed, nSP70-induced harmful effects may be avoided. These results would provide useful information for ensuring the safety of nanomaterials (NMs) and open new frontiers in biological fields by the use of NMs. (paper)

  19. Amorphous nanosilicas induce consumptive coagulopathy after systemic exposure

    Science.gov (United States)

    Nabeshi, Hiromi; Yoshikawa, Tomoaki; Matsuyama, Keigo; Nakazato, Yasutaro; Arimori, Akihiro; Isobe, Masaaki; Tochigi, Saeko; Kondoh, Sayuri; Hirai, Toshiro; Akase, Takanori; Yamashita, Takuya; Yamashita, Kohei; Yoshida, Tokuyuki; Nagano, Kazuya; Abe, Yasuhiro; Yoshioka, Yasuo; Kamada, Haruhiko; Imazawa, Takayoshi; Itoh, Norio; Kondoh, Masuo; Yagi, Kiyohito; Mayumi, Tadanori; Tsunoda, Shin-ichi; Tsutsumi, Yasuo

    2012-02-01

    We previously reported that well-dispersed amorphous nanosilicas with particle size 70 nm (nSP70) penetrate skin and produce systemic exposure after topical application. These findings underscore the need to examine biological effects after systemic exposure to nanosilicas. The present study was designed to examine the biological effects. BALB/c mice were intravenously injected with amorphous nanosilicas of sizes 70, 100, 300, 1000 nm and then assessed for survival, blood biochemistry, and coagulation. As a result, injection of nSP70 caused fatal toxicity, liver damage, and platelet depletion, suggesting that nSP70 caused consumptive coagulopathy. Additionally, nSP70 exerts procoagulant activity in vitro associated with an increase in specific surface area, which increases as diameter reduces. In contrast, nSP70-mediated procoagulant activity was absent in factor XII-deficient plasma. Collectively, we revealed that interaction between nSP70 and intrinsic coagulation factors such as factor XII, were deeply related to nSP70-induced harmful effects. In other words, it is suggested that if interaction between nSP70 and coagulation factors can be suppressed, nSP70-induced harmful effects may be avoided. These results would provide useful information for ensuring the safety of nanomaterials (NMs) and open new frontiers in biological fields by the use of NMs.

  20. Changes in Peak Oxygen Uptake and Plasma Volume in Fit and Unfit Subjects Following Exposure to a Simulation of Microgravity

    National Research Council Canada - National Science Library

    Convertino, Victor

    1997-01-01

    To test the hypothesis that the magnitude of reduction in plasma volume and work capacity following exposure to simulated microgravity is dependent on the initial level of aerobic fitness, peak oxygen uptake (VO2peak...

  1. Troubles in vacuum system and radiation exposure

    International Nuclear Information System (INIS)

    Konno, Osamu

    1978-01-01

    It is about eleven years since the LINAC of 300 MeV in Tohoku University has first accelerated electrons. The maintenance and improvement of the accelerator used more than 10 years now give the related personnel an important problem of radiation exposure. 40 days were required for the maintenance and checking-up in 1977, and other 26 days were used for other construction works. The troubles in the vacuum system occurred 81 times in total. The vacuum system is divided into two subsystems, each being provided with a leak detector. Either of them enables to detect and locate the leak. Silver-alloy brazing of a duct with a cooling water tube has deteriorated in the strength because of repeated baking temperature and/or the copper tubes for cooling have been eroded due to the large local cell action by purified water. The similar phenomena have occurred in RF windows, outside of which is cooled with water. Carbonaceous matter has stuck to the element of the ion pump, but successfully been cleaned. Though the energy compression system was installed for the efficient use of electrons, the troubles due to overheating of the current monitor have increased because of its limited space, and the change of location was made. Considerable surface residual radiation dose was found at some parts of transport system, and a few personnel have been exposed to radiation over 1000 mrem/year as a result of the troubles in vacuum system. (Wakatsuki, Y.)

  2. The ITER Plasma Control System Simulation Platform

    International Nuclear Information System (INIS)

    Walker, M.L.; Ambrosino, G.; De Tommasi, G.; Humphreys, D.A.; Mattei, M.; Neu, G.; Rapson, C.J.; Raupp, G.; Treutterer, W.; Welander, A.S.; Winter, A.

    2015-01-01

    Highlights: • A development and test environment called PCSSP has been constructed for the ITER PCS. • A description of requirements and use cases, a final design and software architecture design, users guide, and a prototype implementation have been delivered. • The prototype implementation was demonstrated at IO in December of 2013. • PCSSP will be deployed for alpha testing to the IO, the development group, and selected other ITER partners upon completion of the next development phase. - Abstract: The Plasma Control System Simulation Platform (PCSSP) is a highly flexible, modular, time-dependent simulation environment developed primarily to support development of the ITER Plasma Control System (PCS). It has been under development since 2011 and is scheduled for first release to users in the ITER Organization (IO) and at selected additional sites in 2015. Modules presently implemented in PCSSP enable exploration of axisymmetric evolution and control, basic kinetic control, and tearing mode suppression. A basic capability for generation of control-relevant events is included, enabling study of exception handling in the PCS, continuous controllers, and PCS architecture. While the control design focus of PCSSP applications tends to require only a moderate level of accuracy and complexity in modules, more complex codes can be embedded or connected to access higher accuracy if needed. This paper describes the background and motivation for PCSSP, provides an overview of the capabilities, architecture, and features of PCSSP, and discusses details of the PCSSP vision and its intended goals and application. Completed work, including architectural design, prototype implementation, reference documents, and IO demonstration of PCSSP, is summarized and example use of PCSSP is illustrated. Near-term high-level objectives are summarized and include preparation for release of an “alpha” version of PCSSP and preparation for the next development phase. High

  3. The ITER Plasma Control System Simulation Platform

    Energy Technology Data Exchange (ETDEWEB)

    Walker, M.L., E-mail: walker@fusion.gat.com [General Atomics, PO Box 85608, San Diego, CA 92186-5608 (United States); Ambrosino, G.; De Tommasi, G. [CREATE/Università di Napoli Federico II, Napoli (Italy); Humphreys, D.A. [General Atomics, PO Box 85608, San Diego, CA 92186-5608 (United States); Mattei, M. [CREATE/Seconda Università di Napoli, Napoli (Italy); Neu, G.; Rapson, C.J.; Raupp, G.; Treutterer, W. [Max Planck Institute for Plasma Physics, Boltzmannstr. 2, 85748 Garching (Germany); Welander, A.S. [General Atomics, PO Box 85608, San Diego, CA 92186-5608 (United States); Winter, A. [ITER Organization, Route de Vinon-sur-Verdon, 13115 St. Paul-lez-Durance (France)

    2015-10-15

    Highlights: • A development and test environment called PCSSP has been constructed for the ITER PCS. • A description of requirements and use cases, a final design and software architecture design, users guide, and a prototype implementation have been delivered. • The prototype implementation was demonstrated at IO in December of 2013. • PCSSP will be deployed for alpha testing to the IO, the development group, and selected other ITER partners upon completion of the next development phase. - Abstract: The Plasma Control System Simulation Platform (PCSSP) is a highly flexible, modular, time-dependent simulation environment developed primarily to support development of the ITER Plasma Control System (PCS). It has been under development since 2011 and is scheduled for first release to users in the ITER Organization (IO) and at selected additional sites in 2015. Modules presently implemented in PCSSP enable exploration of axisymmetric evolution and control, basic kinetic control, and tearing mode suppression. A basic capability for generation of control-relevant events is included, enabling study of exception handling in the PCS, continuous controllers, and PCS architecture. While the control design focus of PCSSP applications tends to require only a moderate level of accuracy and complexity in modules, more complex codes can be embedded or connected to access higher accuracy if needed. This paper describes the background and motivation for PCSSP, provides an overview of the capabilities, architecture, and features of PCSSP, and discusses details of the PCSSP vision and its intended goals and application. Completed work, including architectural design, prototype implementation, reference documents, and IO demonstration of PCSSP, is summarized and example use of PCSSP is illustrated. Near-term high-level objectives are summarized and include preparation for release of an “alpha” version of PCSSP and preparation for the next development phase. High

  4. Antibacterial characteristics of thermal plasma spray system.

    Science.gov (United States)

    Goudarzi, M; Saviz, Sh; Ghoranneviss, M; Salar Elahi, A

    2018-03-15

    The objective of this study is to investigate antibacterial characteristics of a thermal plasma spray system. For this purpose, copper powder was coated on a handmade atmospheric plasma spraying system made by the stainless steel 316 substrate, which is preheated at different temperatures before spraying. A number of deposition characteristics such as antibacterial characteristics, adhesion strength and hardness of coating, was investigated. All of the spray parameters are fixed except the substrate temperature. The chemical composition was analyzed by X-ray diffraction (XRD). A scanning electron microscopy (SEM) and back scattering electron microscopy (BSE) were used to show the coating microstructure, its thickness and also the powder micrograph. The energy dispersive X-ray spectroscopy (EDX) was used to analyze the coating particles. Hardness of the deposition was examined by Vickers tester (HV0.1). Its adhesion strength was declared by cross cut tester (TQC). In addition, the percentage of bactericidal coating was evidenced with Staphylococcus aurous and Escherichia coli bacteria. Study results show that as the substrates temperature increases, the number of splats in the shape of pancake increases, the greatness and percentage of the deposition porosity both decrease. The increment of the substrate temperature leads to more oxidation and makes thicker dendrites on the splat. The enhancement of the substrate temperature also enlarges thickness and efficiency of coating. The interesting results are that antibacterial properties of coatings against the Escherichia coli are more than Staphylococcus aurous bacteria. However the bactericidal percentage of the coatings against Staphylococcus aurous and Escherichia coli bacteria roughly does not change with increasing the substrate temperature. Furthermore, by increment of the substrate temperature, coatings with both high adhesion and hardness are obtained. Accordingly, the temperature of substrate can be an

  5. Posaconazole plasma exposure correlated to intestinal mucositis in allogeneic stem cell transplant patients.

    Science.gov (United States)

    Vanstraelen, Kim; Prattes, Juergen; Maertens, Johan; Lagrou, Katrien; Schoemans, Hélène; Peersman, Nele; Vermeersch, Pieter; Theunissen, Koen; Mols, Raf; Augustijns, Patrick; Annaert, Pieter; Hoenigl, Martin; Spriet, Isabel

    2016-08-01

    Low posaconazole plasma concentrations (PPCs) are frequently encountered in allogeneic hematopoietic stem cell transplant (HSCT) patients, due to variable gastrointestinal absorption. In this study, the impact of intestinal mucositis on posaconazole exposure is investigated. A prospective pharmacokinetic study was performed including allogeneic HSCT patients receiving posaconazole prophylaxis with the oral suspension or tablets. Steady state PPCs were determined using high-performance liquid chromatography-fluorescence detection at the day of transplantation (=day 0), day +7, and +14. Citrulline was measured using liquid chromatography-tandem mass spectrometry to evaluate severity of mucositis, at baseline (day -7 or -6), and at day 0, +7 and +14. Additionally, citrulline plasma concentrations and steady state trough PPCs were determined in hematological patients without HSCT or mucositis. Thirty-four HSCT patients received posaconazole oral suspension together with 25 cL of Coca Cola, 6 HSCT patients received posaconazole tablets and 33 hematological patients not receiving HSCT received posaconazole oral suspension. The median (interquartile range) average PPC was 0.26 mg/L (0.17-0.43), 0.67 mg/L (0.27-1.38), and 1.08 mg/L (0.96-1.38), with suspension in HSCT patients, suspension in hematological patients and tablets in HSCT patients, respectively. A higher trough PPC was encountered with the oral suspension when citrulline plasma concentrations were above 10 μmol/L compared to values below 10 μmol/L (p < 0.001), whereas for tablets, average PPCs remained high with citrulline plasma concentrations below or above 10 μmol/L (p = 0.64). Posaconazole tablets should be preferred to suspension in HSCT patients immediately after transplantation to prevent insufficient plasma exposure due to intestinal mucositis.

  6. An advanced plasma control system for Tore Supra

    Energy Technology Data Exchange (ETDEWEB)

    Wijnands, T.; Martin, G.

    1996-01-01

    First results on plasma control with the new plasma control system of Tore Supra are presented. The system has been especially designed for long pulse operation: plasmas are controlled on reference signals, which can be varied in real time by using diagnostic measurements. On line determination of the global plasma equilibrium has enabled new operation scenarios in which both the power from the poloidal field generators and the total Lower Hybrid (LH) power are used to control the plasma. Experiments with feedback control of the safety factor on the plasma boundary, control of the LH driven current, control of the flux on the plasma boundary and control of the internal inductance are discussed. (author). 12 refs.

  7. An advanced plasma control system for Tore Supra

    International Nuclear Information System (INIS)

    Wijnands, T.; Martin, G.

    1996-01-01

    First results on plasma control with the new plasma control system of Tore Supra are presented. The system has been especially designed for long pulse operation: plasmas are controlled on reference signals, which can be varied in real time by using diagnostic measurements. On line determination of the global plasma equilibrium has enabled new operation scenarios in which both the power from the poloidal field generators and the total Lower Hybrid (LH) power are used to control the plasma. Experiments with feedback control of the safety factor on the plasma boundary, control of the LH driven current, control of the flux on the plasma boundary and control of the internal inductance are discussed. (author)

  8. The modification of nanocomposite hybrid polymer surfaces by exposure to oxygen containing plasmas

    Science.gov (United States)

    Figueiredo, Ashley; Zimmermann, Katherine; Augustine, Brian; Hughes, Chris; Chusuei, Charles

    2006-11-01

    The wetting properties of the surfaces of the nanocomposite hybrid polymer poly[(propylmethacryl-heptaisobutyl- polyhedral oligomeric silsequioxane)-co-(methylmethacrylate)] (POSS-PMMA)has been studied before and after exposure to plasmas containing oxygen. The contact angle of water droplets on the surface showed a substantial decrease after plasma exposure indicating an increase in the hydrophilicity of the surface. A model was developed in which the plasma preferentially removed organic material including both the PMMA backbone and isobutyl groups from the corners of the POSS cages leaving behind a surface characterized by the silicon oxide-like POSS material. Measurements of surface concentrations of oxygen, silicon, and carbon by x-ray photoelectron spectroscopy (XPS) showed an increase in the amount of oxygen and silicon compared to carbon and the appropriate chemical shifts were observed in the XPS data to support the model of Si-O enrichment on the surface. Variable angle spectroscopic ellipsometry (VASE) and atomic force microscopy (AFM) measurements also supported the model and these results will be presented.

  9. Stress hormonal changes in the brain and plasma after acute noise exposure in mice.

    Science.gov (United States)

    Jin, Sang Gyun; Kim, Min Jung; Park, So Young; Park, Shi Nae

    2017-06-01

    To investigate the effects of acute noise stress on two amine stress hormones, norepinephrine (NE) and 5-hydroxyindoleacetic acid (5-HIAA) in the brain and plasma of mice after noise exposure. Mice were grouped into the control and noise groups. Mice in the noise group were exposed to white noise of 110dB sound pressure level for 60min. Auditory brainstem response thresholds, distortion product otoacoustic emissions, the organ of Corti grading scores, western blots of NE/5-HIAA in the whole brain and hippocampus, and the plasma levels of NE/5-HIAA were compared between the two groups. Significant hearing loss and cochlear damage were demonstrated in the noise group. NE and 5-HIAA in the hippocampus were elevated in the noise group (p=0.019/0.022 for NE/5-HIAA vs. the control). Plasma levels of NE and 5-HIAA were not statistically different between the groups (p=0.052/0.671 for NE/5-HIAA). Hearing loss with outer hair cell dysfunction and morphological changes of the organ of Corti after noise exposure in C57BL/6 mice proved the reliability of our animal model as an acute noise stress model. NE and 5-HIAA are suggested to be the potential biomarkers for acute noise stress in the hippocampus. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  10. Monitoring system for thermal plasma; Sistema de monitoreo para plasma termico

    Energy Technology Data Exchange (ETDEWEB)

    Romero G, M.; Vilchis P, A.E. [Instituto Nacional de Investigaciones Nucleares, A.P. 18-1027, 11801 Mexico D.F. (Mexico)

    1999-07-01

    In the Thermal plasma applications laboratory it has been the degradation project of oils for isolation in transformers. These are a very hazardous residues and at this time in the country they are stored in metal barrels. It has been the intention to undergo the oils to plasma for degradate them to non-hazardous residues. The system behavior must be monitored to establish the thermal plasma behavior. (Author)

  11. Exposure of liquid lithium confined in a capillary structure to high plasma fluxes in PILOT-PSI—Influence of temperature on D retention

    Energy Technology Data Exchange (ETDEWEB)

    Martin-Rojo, A.B., E-mail: anabmr2010@hotmail.com [Ciemat, Laboratorio Nacional de Fusión, Av Complutense 22, 28040 Madrid (Spain); Oyarzabal, E. [Ciemat, Laboratorio Nacional de Fusión, Av Complutense 22, 28040 Madrid (Spain); Fundación UNED Guzman el Bueno, 133, 28003 Madrid (Spain); Morgan, T.W. [FOM Institute for Plasma Physics Rijnhuizen, Edisonbaan 14, 3439 MN, Nieuwegein (Netherlands); Tabarés, F.L. [Ciemat, Laboratorio Nacional de Fusión, Av Complutense 22, 28040 Madrid (Spain)

    2017-04-15

    Experiments on deuterium retention on liquid lithium confined in a capillary structure followed by ex-situ thermal desorption spectrometry (TDS) at high plasma fluxes (∼10{sup 23} m{sup 2} s{sup −1}) and high temperatures (440 °C and 580 °C) have been performed. Deuterium plasmas were generated at the PILOT-PSI linear plasma device and the targets were a 30 mm diameter stainless steel disc, 5 mm thick, covered with a porous mesh and filled with lithium. The settings (current) of the plasma source were varied in order to get different sample surface temperatures during irradiation. The targets were kept at floating potential during the exposure. Hydrogen and Li emission signals were monitored during the plasma exposure and TDS analysis was made afterwards in a separated system. Decreased retention at high exposure temperatures was deduced from the analysis of the hydrogen emission signals. Nevertheless, the results from TDS signal analysis were not conclusive.

  12. Levels of oxylipins, endocannabinoids and related lipids in plasma before and after low-level exposure to acrolein in healthy individuals and individuals with chemical intolerance.

    Science.gov (United States)

    Claeson, Anna-Sara; Gouveia-Figueira, Sandra; Häggström, Jenny; Fowler, Christopher J; Nording, Malin L

    2017-06-01

    Oxylipins and endocannabinoids play important biological roles, including effects upon inflammation. It is not known whether the circulating levels of these lipids are affected by inhalation of the environmental pollutant acrolein. In the present study, we have investigated the consequences of low-level exposure to acrolein on oxylipin, endocannabinoid and related lipid levels in the plasma of healthy individuals and individuals with chemical intolerance (CI), an affliction with a suggested inflammatory origin. Participants were exposed twice (60min) to heptane and a mixture of heptane and acrolein. Blood samples were collected before exposure, after and 24h post-exposure. There were no overt effects of acrolein exposure on the oxylipin lipidome or endocannibinoids detectable in the bloodstream at the time points investigated. No relationship between basal levels or levels after exposure to acrolein and CI could be identified. This implicates a minor role of inflammatory mediators on the systemic level in CI. Copyright © 2017 Elsevier Ltd. All rights reserved.

  13. Automatic system for processing the plasma radiation spectra

    International Nuclear Information System (INIS)

    Isakaev, Eh.Kh.; Markin, A.V.; Khajmin, V.A.; Chinnov, V.F.

    2001-01-01

    One is tackling a problem to ensure computer for processing of experimental data when studying plasma obtained due to the present day systems to acquire information. One elaborated rather simple and reliable programs for processing. The system is used in case of plasma quantitative spectroscopy representing the classical and most widely used method to analyze the parameters and the properties of low-temperature and high-temperature plasma [ru

  14. Plasma distribution of cathodic ARC deposition system

    International Nuclear Information System (INIS)

    Anders, S.; Raoux, S.; Krishnan, K.; MacGill, R.A.; Brown, I.G.

    1996-01-01

    The plasma distribution using a cathodic arc plasma source with and without magnetic macroparticle filter has been determined by depositing on a transparent plastic substrate and measuring the film absorption. It was found that the width of the distribution depends on the arc current, and it also depends on the cathode material which leads to a spatial separation of the elements when an alloy cathode is used. By applying a magnetic multicusp field near the exit of the magnetic filter, it was possible to modify the plasma distribution and obtain a flat plasma profile with a constant and homogeneous elemental distribution

  15. Effects of photoirradiation in UV and VUV regions during plasma exposure to polymers

    International Nuclear Information System (INIS)

    Cho, Ken; Setsuhara, Yuichi; Takenaka, Kosuke; Shiratani, Masaharu; Sekine, Makoto; Hori, Masaru

    2011-01-01

    Interactions between photons irradiated from Ar-O 2 mixture plasmas and polymer surfaces were investigated on the basis of depth analyses of chemical bonding states in the nano-surface layer of polyethylene terephthalate (PET) films via hard X-ray photoelectron spectroscopy (HXPES) and conventional X-ray photoelectron spectroscopy (XPS). The PET films were exposed to photons from the Ar-O 2 mixture plasmas by covering the PET samples with MgF 2 and quartz windows as optical filters for evaluation of photoirradiation effects in ultraviolet (UV) and vacuum ultraviolet (VUV) regions. The HXPES results indicated that the degradation of the chemical bonding states due to photoirradiation in regions was insignificant in deeper regions up to about 50 nm from the surface. Whereas, conventional XPS analysis showed that C-O bond, O=C-O bond and C=O bond increased after photoirradiation in UV and VUV regions. These results suggest that the increase in oxygen functionalities (C-O bond, O=C-O bond and C=O bond) may be attributed to chemical reactions and/or terminations of scissed bonds via photodecompositions of the polymer with oxygen and/or OH species (oxygen molecules and radicals during plasma exposure and/or oxygen molecules and moisture after taking the PET samples out of the plasma reactor to the ambient air) in the vicinity of the sample surface.

  16. CoSi{sub x} contact resistance after etching and ashing plasma exposure

    Energy Technology Data Exchange (ETDEWEB)

    Katahira, Ken; Fukasawa, Masanaga; Kobayashi, Shoji; Takizawa, Toshifumi; Isobe, Michio; Hamaguchi, Satoshi; Nagahata, Kazunori; Tatsumi, Tetsuya [Nagasaki Production Division 1, Sony Semiconductor Kyushu Corporation, 1883-43 Tsukuba-machi, Isahaya-shi, Nagasaki 854-0065 (Japan); Semiconductor Technology Development Division, Semiconductor Business Group, Sony Corporation, 4-14-1 Asahi-cho, Atsugi-shi, Kanagawa 243-0014 (Japan); Center for Atomic and Molecular Technologies, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871 (Japan); Semiconductor Technology Development Division, Semiconductor Business Group, Sony Corporation, 4-14-1 Asahi-cho, Atsugi-shi, Kanagawa 243-0014 (Japan)

    2009-07-15

    The authors investigated the contact resistance fluctuation caused by CoSi{sub x} damage in plasma etching and ashing processes. They found that CoSi{sub x} layers damaged by plasma process exposure are readily oxidized when exposed to air resulting in increased resistance. They also found that the contact resistance increases more when CH{sub 3}F is used instead of CF{sub 4} during etching process. The lower the mass number of dominant ions becomes, the deeper the ions penetrate. Molecular dynamics simulation revealed that dissociated species from lighter ions penetrate deeper and that this stimulates deeper oxidation. They also found that contact resistance further increased by using postetch ashing plasma even in an H{sub 2}/N{sub 2} ashing process in which O{sub 2} was not used. Here, too, the reason for this is that the ion penetration causes deep oxidation. They observed that the contact resistance has a linear relationship with the oxide concentration in CoSi{sub x}. This leads to the conclusion that it is essential to precisely control the ion energy as well as to properly select the ion species in the plasma process in the fabrication of next-generation semiconductor devices.

  17. CoSix contact resistance after etching and ashing plasma exposure

    International Nuclear Information System (INIS)

    Katahira, Ken; Fukasawa, Masanaga; Kobayashi, Shoji; Takizawa, Toshifumi; Isobe, Michio; Hamaguchi, Satoshi; Nagahata, Kazunori; Tatsumi, Tetsuya

    2009-01-01

    The authors investigated the contact resistance fluctuation caused by CoSi x damage in plasma etching and ashing processes. They found that CoSi x layers damaged by plasma process exposure are readily oxidized when exposed to air resulting in increased resistance. They also found that the contact resistance increases more when CH 3 F is used instead of CF 4 during etching process. The lower the mass number of dominant ions becomes, the deeper the ions penetrate. Molecular dynamics simulation revealed that dissociated species from lighter ions penetrate deeper and that this stimulates deeper oxidation. They also found that contact resistance further increased by using postetch ashing plasma even in an H 2 /N 2 ashing process in which O 2 was not used. Here, too, the reason for this is that the ion penetration causes deep oxidation. They observed that the contact resistance has a linear relationship with the oxide concentration in CoSi x . This leads to the conclusion that it is essential to precisely control the ion energy as well as to properly select the ion species in the plasma process in the fabrication of next-generation semiconductor devices.

  18. Tokamak plasma current disruption infrared control system

    International Nuclear Information System (INIS)

    Kugel, H.W.; Ulrickson, M.

    1987-01-01

    This patent describes a device for magnetically confining a plasma driven by a plasma current and contained within a toroidal vacuum chamber, the device having an inner toroidal limiter on an inside wall of the vacuum chamber and an arrangement for the rapid prediction and control in real time of a major plasma disruption. The arrangement is described which includes: scanning means sensitive to infrared radiation emanating from within the vacuum chamber, the infrared radiation indicating the temperature along a vertical profile of the inner toroidal limiter. The scanning means is arranged to observe the infrared radiation and to produce in response thereto an electrical scanning output signal representative of a time scan of temperature along the vertical profile; detection means for analyzing the scanning output signal to detect a first peaked temperature excursion occurring along the profile of the inner toroidal limiter, and to produce a detection output signal in repsonse thereto, the detection output signal indicating a real time prediction of a subsequent major plasma disruption; and plasma current reduction means for reducing the plasma current driving the plasma, in response to the detection output signal and in anticipation of a subsequent major plasma disruption

  19. Effect of high flux plasma exposure on the micro-structural and -mechanical properties of ITER specification tungsten

    Energy Technology Data Exchange (ETDEWEB)

    Dubinko, A., E-mail: adubinko@sckcen.be [Institute for Nuclear Material Sciences, SCK-CEN, 2400 Mol (Belgium); Department of Applied Physics, Ghent University, 9000 Ghent (Belgium); Terentyev, D. [Institute for Nuclear Material Sciences, SCK-CEN, 2400 Mol (Belgium); National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), Kashirskoe shosse 31, 115409 Moscow (Russian Federation); Bakaeva, A. [Institute for Nuclear Material Sciences, SCK-CEN, 2400 Mol (Belgium); Department of Applied Physics, Ghent University, 9000 Ghent (Belgium); Pardoen, T. [Institute of Mechanics, Materials and Civil Engineering, Université catholique de Louvain, Place Sainte Barbe 2 L5.02.02, 1348 Louvain‐la‐Neuve (Belgium); Zibrov, M. [Department of Applied Physics, Ghent University, 9000 Ghent (Belgium); Max-Planck-Institut für Plasmaphysik, Boltzmannstraße 2, D-85748 Garching (Germany); FOM Institute DIFFER – Dutch Institute for Fundamental Energy Research, De Zaale 20, 5612 AJ Eindhoven (Netherlands); Physik-Department E28, Technische Universität München, James-Franck-Straße 1, D-85748 Garching (Germany); National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), Kashirskoe shosse 31, 115409 Moscow (Russian Federation); Morgan, T.W. [FOM Institute DIFFER – Dutch Institute for Fundamental Energy Research, De Zaale 20, 5612 AJ Eindhoven (Netherlands)

    2017-02-15

    Highlights: • Plasma exposure induces dislocation-dominated microstructure. • The exposure-induced changes in microstructure vanish beyond a depth of 12–15 μm. • Surface hardness after the plasma exposure increases significantly in the sub-surface region of 1.5–3 μm. - Abstract: We have performed a combined study using transmission electron microscopy (TEM), nuclear reaction analysis (NRA) and nano-indentation (NI) techniques to reveal the impact of high flux plasma exposure on the properties of a sub-surface region of the commercially available pure tungsten fabricated following the ITER specification. TEM examination revealed the formation of a dense dislocation network and dislocation tangles, resulting in a strong increase in the dislocation density by at least one order of magnitude as compared to the bulk density. The plasma-induced dislocation microstructure vanishes within a depth of about 10–15 μm from the top of the exposed surface. Surface hardness after the plasma exposure was characterized by NI and was found to increase significantly in the sub-surface region of 1.5–3 μm. That was attributed to the resistance of the plasma-induced dislocation networks and deuterium-induced defects, whose presence within a depth of ∼1 μm was unambiguously detected by the NRA measurements as well.

  20. Defects introduced by Ar plasma exposure in GaAs probed by monoenergetic positron beam

    Energy Technology Data Exchange (ETDEWEB)

    Uedono, Akira; Tanigawa, Shoichiro [Tsukuba Univ., Ibaraki (Japan). Inst. of Materials Science; Kawano, Takao; Wada, Kazumi; Nakanishi, Hideo

    1994-10-01

    Ar-plasma-induced defects in n-type GaAs were probed by a monoenergetic positron beam. The depth distribution of the defects was obtained from measurements of Doppler broadening profiles of the annihilation radiation as a function of incident positron energy. The damaged layer induced by the exposure was found to extend far beyond the stopping range of Ar ions, and the dominant defects were identified as interstitial-type defects. After 100degC annealing, such defects were annealed. Instead, vacancy-type defects were found to be the dominant defects in the subsurface region. (author).

  1. Comparative Plasma Exposure of Albendazole after Administration of Rapidly Disintegrating Tablets in Dogs

    Directory of Open Access Journals (Sweden)

    Silvina G. Castro

    2013-01-01

    Full Text Available The main objectives of this study were (a to evaluate the in vitro performance of the rapid disintegration tablets as a way to improve the solid dispersions and (b to study the in vivo pharmacokinetics of the albendazole modified formulation in dogs. Rapid disintegration of tablets seems to be a key factor for efficiency of solid dispersions with regard to improvement of the albendazole bioavailability. The in vivo assays performed on dogs showed a marked increase in drug plasma exposure when albendazole was given in solid dispersions incorporated into rapid disintegration tablets compared with conventional solid dosage form.

  2. Developing the science and technology for the Material Plasma Exposure eXperiment

    Science.gov (United States)

    Rapp, J.; Biewer, T. M.; Bigelow, T. S.; Caneses, J. F.; Caughman, J. B. O.; Diem, S. J.; Goulding, R. H.; Isler, R. C.; Lumsdaine, A.; Beers, C. J.; Bjorholm, T.; Bradley, C.; Canik, J. M.; Donovan, D.; Duckworth, R. C.; Ellis, R. J.; Graves, V.; Giuliano, D.; Green, D. L.; Hillis, D. L.; Howard, R. H.; Kafle, N.; Katoh, Y.; Lasa, A.; Lessard, T.; Martin, E. H.; Meitner, S. J.; Luo, G.-N.; McGinnis, W. D.; Owen, L. W.; Ray, H. B.; Shaw, G. C.; Showers, M.; Varma, V.; the MPEX Team

    2017-11-01

    Linear plasma generators are cost effective facilities to simulate divertor plasma conditions of present and future fusion reactors. They are used to address important R&D gaps in the science of plasma material interactions and towards viable plasma facing components for fusion reactors. Next generation plasma generators have to be able to access the plasma conditions expected on the divertor targets in ITER and future devices. The steady-state linear plasma device MPEX will address this regime with electron temperatures of 1-10 eV and electron densities of 1021{\\text{}}-1020 m-3 . The resulting heat fluxes are about 10 MW m-2 . MPEX is designed to deliver those plasma conditions with a novel Radio Frequency plasma source able to produce high density plasmas and heat electron and ions separately with electron Bernstein wave (EBW) heating and ion cyclotron resonance heating with a total installed power of 800 kW. The linear device Proto-MPEX, forerunner of MPEX consisting of 12 water-cooled copper coils, has been operational since May 2014. Its helicon antenna (100 kW, 13.56 MHz) and EC heating systems (200 kW, 28 GHz) have been commissioned and 14 MW m-2 was delivered on target. Furthermore, electron temperatures of about 20 eV have been achieved in combined helicon and ECH heating schemes at low electron densities. Overdense heating with EBW was achieved at low heating powers. The operational space of the density production by the helicon antenna was pushed up to 1.1 × 1020 m-3 at high magnetic fields of 1.0 T at the target. The experimental results from Proto-MPEX will be used for code validation to enable predictions of the source and heating performance for MPEX. MPEX, in its last phase, will be capable to expose neutron-irradiated samples. In this concept, targets will be irradiated in ORNL’s High Flux Isotope Reactor and then subsequently exposed to fusion reactor relevant plasmas in MPEX.

  3. Atomic layer deposition of Al2O3 on GaSb using in situ hydrogen plasma exposure

    International Nuclear Information System (INIS)

    Ruppalt, Laura B.; Cleveland, Erin R.; Champlain, James G.; Prokes, Sharka M.; Brad Boos, J.; Park, Doewon; Bennett, Brian R.

    2012-01-01

    In this report, we study the effectiveness of hydrogen plasma surface treatments for improving the electrical properties of GaSb/Al 2 O 3 interfaces. Prior to atomic layer deposition of an Al 2 O 3 dielectric, p-GaSb surfaces were exposed to hydrogen plasmas in situ, with varying plasma powers, exposure times, and substrate temperatures. Good electrical interfaces, as indicated by capacitance-voltage measurements, were obtained using higher plasma powers, longer exposure times, and increasing substrate temperatures up to 250 °C. X-ray photoelectron spectroscopy reveals that the most effective treatments result in decreased SbO x , decreased Sb, and increased GaO x content at the interface. This in situ hydrogen plasma surface preparation improves the semiconductor/insulator electrical interface without the use of wet chemical pretreatments and is a promising approach for enhancing the performance of Sb-based devices.

  4. Computer simulation of plasma turbulence in open systems

    International Nuclear Information System (INIS)

    Sigov, Yu.S.

    1982-01-01

    A short review of the results of kinetic simulation of collective phenomena in open plasma systems with the variable total energy and number of particles, i.e., the particle and energy fluxes on boundary surfaces and/or their internal sources and channels is given. Three specific problems are considered in different detail for such systems in one-dimensional geometry: the generation and evolution of double layers in a currently unstable plasma; the collisionless relaxation of strongly non-equilibrium electron distributions; the Langmuir collapse and strong electrostatic turbulence in systems with parametric excitation of a plasma by an external pumping wave and with cooling the fast non-Maxwell electrons. In all these cases the non-linearity and a collective character of processes give examples of new dissipative plasma structures that essentially widen our idea about the nature of the plasma turbulence in non-homogeneous open systems. (Auth.)

  5. Microwave Plasma System: PVA Tepla 300

    Data.gov (United States)

    Federal Laboratory Consortium — Description:CORAL Name: Microwave AsherA tool using microwave oxygen plasma to remove organics on the surfacesSpecifications / Capabilities:Frequency: 2.45 GHzPower:...

  6. Plasma heating due to X-B mode conversion in a cylindrical ECR plasma system

    Energy Technology Data Exchange (ETDEWEB)

    Yadav, V.K.; Bora, D. [Institute for Plasma Research, Bhat, Gandhinagar, Gujarat (India)

    2004-07-01

    Extra Ordinary (X) mode conversion to Bernstein wave near Upper Hybrid Resonance (UHR) layer plays an important role in plasma heating through cyclotron resonance. Wave generation at UHR and parametric decay at high power has been observed during Electron Cyclotron Resonance (ECR) heating experiments in toroidal magnetic fusion devices. A small linear system with ECR and UHR layer within the system has been used to conduct experiments on X-B conversion and parametric decay process as a function of system parameters. Direct probing in situ is conducted and plasma heating is evidenced by soft x-ray emission measurement. Experiments are performed with hydrogen plasma produced with 160-800 W microwave power at 2.45 GHz of operating frequency at 10{sup -3} mbar pressure. The axial magnetic field required for ECR is such that the resonant surface (B = 875 G) is situated at the geometrical axis of the plasma system. Experimental results will be presented in the paper. (authors)

  7. Criteria for inhalation exposure systems utilizing concurrent flow spirometry

    International Nuclear Information System (INIS)

    Raabe, O.G.; Yeh, H.C.

    1974-01-01

    Principles are given for the design and operation of a new class of inhalation exposure systems utilizing concurrent flow spirometry (CFS), a simple method for providing realtime measurement of respiratory volumes and rates during inhalation exposure by mouth or nose of individual experimental animals or man to aerosols or gases. This technique is especially useful for inhalation exposure of larger experimental animals, such as horses, where whole-body plethysmography is usually impractical. Difficulties encountered with conventional exposure systems in maintenance of uniform aerosol or gas concentrations and prevention of large pressure excursions in the exposure chamber during breathing are obviated by systems utilizing the principles of concurrent flow spirometry. For illustration, two exposure units with CFS are described, one for exposure of Beagle dogs and one for ponies. (U.S.)

  8. Sheath and plasma parameters in a magnetized plasma system

    Indian Academy of Sciences (India)

    through the negatively biased grid from the source region into the diffused region. It is observed that the electron temperature increases with the magnetic field in the diffused region whereas it decreases in the source region of the system for a constant grid biasing voltage. Also, investigation is done to see the change of ...

  9. Association between arsenic exposure and plasma cholinesterase activity: a population based study in Bangladesh

    Directory of Open Access Journals (Sweden)

    Karim Md Rezaul

    2010-07-01

    Full Text Available Abstract Background Arsenic is a potent pollutant that has caused an environmental catastrophe in certain parts of the world including Bangladesh where millions of people are presently at risk due to drinking water contaminated by arsenic. Chronic arsenic exposure has been scientifically shown as a cause for liver damage, cancers, neurological disorders and several other ailments. The relationship between plasma cholinesterase (PChE activity and arsenic exposure has not yet been clearly documented. However, decreased PChE activity has been found in patients suffering liver dysfunction, heart attack, cancer metastasis and neurotoxicity. Therefore, in this study, we evaluated the PChE activity in individuals exposed to arsenic via drinking water in Bangladesh. Methods A total of 141 Bangladeshi residents living in arsenic endemic areas with the mean arsenic exposure of 14.10 ± 3.27 years were selected as study subjects and split into tertile groups based on three water arsenic concentrations: low ( 265 μg/L. Study subjects were further sub-divided into two groups (≤50 μg/L and > 50 μg/L based on the recommended upper limit of water arsenic concentration (50 μg/L in Bangladesh. Blood samples were collected from the study subjects by venipuncture and arsenic concentrations in drinking water, hair and nail samples were measured by Inductively Coupled Plasma Mass Spectroscopy (ICP-MS. PChE activity was assayed by spectrophotometer. Results Arsenic concentrations in hair and nails were positively correlated with the arsenic levels in drinking water. Significant decreases in PChE activity were observed with increasing concentrations of arsenic in water, hair and nails. The average levels of PChE activity in low, medium and high arsenic exposure groups were also significantly different between each group. Lower levels of PChE activity were also observed in the > 50 μg/L group compared to the ≤50 μg/L group. Moreover, PChE activity was

  10. Effect of high-flux H/He plasma exposure on tungsten damage due to transient heat loads

    Energy Technology Data Exchange (ETDEWEB)

    De Temmerman, G., E-mail: gregory.detemmerman@iter.org [FOM Institute DIFFER, Dutch Institute for Fundamental Energy Research, Association EURATOM-FOM, Trilateral Euregion Cluster, Postbus 1207, 3430BE Nieuwegein (Netherlands); ITER Organization, Route de Vinon sur Verdon, CS 90 096, 13067 Saint Paul-lez-Durance (France); Morgan, T.W.; Eden, G.G. van; Kruif, T. de [FOM Institute DIFFER, Dutch Institute for Fundamental Energy Research, Association EURATOM-FOM, Trilateral Euregion Cluster, Postbus 1207, 3430BE Nieuwegein (Netherlands); Wirtz, M. [Forschungszentrum Jülich GmbH, Institute of Energy and Climate Research – Microstructure and Properties of Materials (IEK-2), EURATOM Association, 52425 Jülich (Germany); Matejicek, J.; Chraska, T. [Institute of Plasma Physics, Association EURATOM-IPP, CR Prague (Czech Republic); Pitts, R.A. [ITER Organization, Route de Vinon sur Verdon, CS 90 096, 13067 Saint Paul-lez-Durance (France); Wright, G.M. [MIT Plasma Science and Fusion Center, 77 Massachusetts Ave., Cambridge, MA 02139 (United States)

    2015-08-15

    The thermal shock behaviour of tungsten exposed to high-flux plasma is studied using a high-power laser. The cases of laser-only, sequential laser and hydrogen (H) plasma and simultaneous laser plus H plasma exposure are studied. H plasma exposure leads to an embrittlement of the material and the appearance of a crack network originating from the centre of the laser spot. Under simultaneous loading, significant surface melting is observed. In general, H plasma exposure lowers the heat flux parameter (F{sub HF}) for the onset of surface melting by ∼25%. In the case of He-modified (fuzzy) surfaces, strong surface deformations are observed already after 1000 laser pulses at moderate F{sub HF} = 19 MJ m{sup −2} s{sup −1/2}, and a dense network of fine cracks is observed. These results indicate that high-fluence ITER-like plasma exposure influences the thermal shock properties of tungsten, lowering the permissible transient energy density beyond which macroscopic surface modifications begin to occur.

  11. Surface type conversion of CuInSe2 with H2S plasma exposure: A photoemission investigation

    International Nuclear Information System (INIS)

    Nelson, A.J.; Frigo, S.P.; Rosenberg, R.

    1995-01-01

    Surface type conversion of CuInSe 2 by H 2 S plasma exposure was studied by synchrotron radiation soft x-ray photoemission spectroscopy. The low power H 2 S plasma was generated with a commercial electron cyclotron resonance plasma source using pure H 2 S with the plasma exposure being performed at 400 degree C. In situ photoemission measurements were acquired after each plasma exposure in order to observe changes in the valence band electronic structure as well as changes in the In 4d and Se 3d core lines. The results were correlated in order to relate changes in surface chemistry to the electronic structure. These measurements indicate that the H 2 S plasma exposure type converts the n-type CuInSe 2 surface to a p-type surface at this elevated temperature and that the magnitude of the band bending is 0.5 eV, resulting in a homojunction interface. copyright 1995 American Vacuum Society

  12. Evolution of Spark plasma using nitrogen laser shadowgraphy system

    International Nuclear Information System (INIS)

    Ishiekwene, G.C.

    1994-07-01

    A simple, low cost, home built high power nitrogen laser is used as the light source for a shadowgraphy system. A series of shadowgrams depicting the temporal growth of a spark plasma discharge is obtained. The results could be useful in plasma diagnostic studies. (author). 5 refs, 6 figs

  13. Mechanical considerations for MFTF-B plasma-diagnostic system

    International Nuclear Information System (INIS)

    Thomas, S.R. Jr.; Wells, C.W.

    1981-01-01

    The reconfiguration of MFTF to a tandem mirror machine with thermal barriers has caused a significant expansion in the physical scope of plasma diagnostics. From a mechanical perspective, it complicates the plasma access, system interfaces, growth and environmental considerations. Conceptual designs characterize the general scope of the design and fabrication which remains to be done

  14. Effects of electromagnetic fields exposure on plasma hormonal and inflammatory pathway biomarkers in male workers of a power plant

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Zhaopin; Fei, Ying; Liu, Hui [Zhejiang Univ., Hangzhou (China). Dept. of Epidemiology and Health Statistics; Zhejiang Univ., Hangzhou (China). Chronic Disease Research Inst.; and others

    2016-01-15

    The potential health risks of electromagnetic fields (EMFs) have currently raised considerable public concerns. The aim of this study was to evaluate the effects of EMF exposure on levels of plasma hormonal and inflammatory pathway biomarkers in male workers of an electric power plant. Seventy-seven male workers with high occupational EMF exposure and 77 male controls with low exposure, matched by age, were selected from a cross-sectional study. Moreover, high EMF exposure group was with walkie-talkies usage and exposed to power frequency EMF at the work places for a longer duration than control group. A questionnaire was applied to obtain relevant information, including sociodemographic characteristics, lifestyle factors, and EMF exposures. Plasma levels of testosterone, estradiol, melatonin, NF-KB, heat-shock protein (HSP) 70, HSP27, and TET1 were determined by an enzyme-linked immunosorbent assay. EMF exposure group had statistically significantly lower levels of testosterone (β = -0.3 nmol/L, P = 0.015), testosterone/estradiol (T/E2) ratio (β = -15.6, P = 0.037), and NF-KB (β = -20.8 ng/L, P = 0.045) than control group. Moreover, joint effects between occupational EMF exposure and employment duration, mobile phone fees, years of mobile phone usage, and electric fees on levels of testosterone and T/E2 ratio were observed. Nevertheless, no statistically significant associations of EMF exposures with plasma estradiol, melatonin, HSP70, HSP27, and TET1 were found. The findings showed that chronic exposure to EMF could decrease male plasma testosterone and T/E2 ratio, and it might possibly affect reproductive functions in males. No significant associations of EMF exposure with inflammatory pathway biomarkers were found.

  15. Combined impact of transient heat loads and steady-state plasma exposure on tungsten

    Energy Technology Data Exchange (ETDEWEB)

    Huber, Alexander, E-mail: A.Huber@fz-juelich.de [Forschungszentrum Jülich GmbH, Institut für Energie- und Klimaforschung, 52425 Jülich (Germany); Wirtz, Marius; Sergienko, Gennady; Steudel, Isabel [Forschungszentrum Jülich GmbH, Institut für Energie- und Klimaforschung, 52425 Jülich (Germany); Arakcheev, Aleksey; Burdakov, Aleksander [Budker Institute of Nuclear Physics (BINP), Novosibirsk 630090 (Russian Federation); Esser, Hans Guenter; Freisinger, Michaele; Kreter, Arkadi; Linke, Jochen; Linsmeier, Christian; Mertens, Philippe; Möller, Sören; Philipps, Volker; Pintsuk, Gerald; Reinhart, Michael; Schweer, Bernd [Forschungszentrum Jülich GmbH, Institut für Energie- und Klimaforschung, 52425 Jülich (Germany); Shoshin, Andrey [Budker Institute of Nuclear Physics (BINP), Novosibirsk 630090 (Russian Federation); Terra, Alexis; Unterberg, Bernhard [Forschungszentrum Jülich GmbH, Institut für Energie- und Klimaforschung, 52425 Jülich (Germany)

    2015-10-15

    Highlights: • W-samples under combined loading conditions show a lower damage threshold. • The pre-loaded W-samples show a lower damage threshold due to the D- embrittlement. • Pronounced increase of the D retention has been observed during the combined loads. • Enhanced blister formation has been observed under combined loading conditions. - Abstract: Cracking thresholds and crack patterns in tungsten targets have been studied in recent experiments after repetitive ITER-like ELM heat pulses in combination with plasma exposure in PSI-2 (Γ{sub target} = 2.5–4.0 × 10{sup 21} m{sup −2} s{sup −1}, ion energy on surface E{sub ion} = 60 eV, T{sub e} ≈ 10 eV). The heat pulses were simulated by laser irradiation. A Nd:YAG laser with energy per pulse of up to 32 J and a duration of 1 ms at the fundamental wavelength (λ = 1064 nm, repetition rate 0.5 Hz) was used to irradiate ITER-grade W samples with repetitive heat loads. In contrast to pure thermal exposure with a laser beam where the damage threshold under pure heat loads for ITER-grade W lies between 0.38 and 0.76 GW/m{sup 2}, the experiments with pre-loaded W-samples as well as under combined loading conditions show a lower damage threshold of 0.3 GW/m{sup 2}. This is probably due to deuterium embrittlement and/or a higher defect concentration in a region close to the surface due to supersaturation with deuterium. A pronounced increase in the D retention (more than a factor of five) has been observed during the combined transient heat loads and plasma exposure. Enhanced blister formation has been observed under these combined loading conditions.

  16. Combined impact of transient heat loads and steady-state plasma exposure on tungsten

    International Nuclear Information System (INIS)

    Huber, Alexander; Wirtz, Marius; Sergienko, Gennady; Steudel, Isabel; Arakcheev, Aleksey; Burdakov, Aleksander; Esser, Hans Guenter; Freisinger, Michaele; Kreter, Arkadi; Linke, Jochen; Linsmeier, Christian; Mertens, Philippe; Möller, Sören; Philipps, Volker; Pintsuk, Gerald; Reinhart, Michael; Schweer, Bernd; Shoshin, Andrey; Terra, Alexis; Unterberg, Bernhard

    2015-01-01

    Highlights: • W-samples under combined loading conditions show a lower damage threshold. • The pre-loaded W-samples show a lower damage threshold due to the D- embrittlement. • Pronounced increase of the D retention has been observed during the combined loads. • Enhanced blister formation has been observed under combined loading conditions. - Abstract: Cracking thresholds and crack patterns in tungsten targets have been studied in recent experiments after repetitive ITER-like ELM heat pulses in combination with plasma exposure in PSI-2 (Γ_t_a_r_g_e_t = 2.5–4.0 × 10"2"1 m"−"2 s"−"1, ion energy on surface E_i_o_n = 60 eV, T_e ≈ 10 eV). The heat pulses were simulated by laser irradiation. A Nd:YAG laser with energy per pulse of up to 32 J and a duration of 1 ms at the fundamental wavelength (λ = 1064 nm, repetition rate 0.5 Hz) was used to irradiate ITER-grade W samples with repetitive heat loads. In contrast to pure thermal exposure with a laser beam where the damage threshold under pure heat loads for ITER-grade W lies between 0.38 and 0.76 GW/m"2, the experiments with pre-loaded W-samples as well as under combined loading conditions show a lower damage threshold of 0.3 GW/m"2. This is probably due to deuterium embrittlement and/or a higher defect concentration in a region close to the surface due to supersaturation with deuterium. A pronounced increase in the D retention (more than a factor of five) has been observed during the combined transient heat loads and plasma exposure. Enhanced blister formation has been observed under these combined loading conditions.

  17. Plasma flow measurements in the Prototype-Material Plasma Exposure eXperiment (Proto-MPEX) and comparison with B2.5-Eirene modeling

    Science.gov (United States)

    Kafle, N.; Owen, L. W.; Caneses, J. F.; Biewer, T. M.; Caughman, J. B. O.; Donovan, D. C.; Goulding, R. H.; Rapp, J.

    2018-05-01

    The Prototype Material Plasma Exposure eXperiment (Proto-MPEX) at Oak Ridge National Laboratory is a linear plasma device that combines a helicon plasma source with additional microwave and radio frequency heating to deliver high plasma heat and particle fluxes to a target. Double Langmuir probes and Thomson scattering are being used to measure local electron temperature and density at various radial and axial locations. A recently constructed Mach-double probe provides the added capability of simultaneously measuring electron temperatures ( T e), electron densities ( n e), and Mach numbers (M). With this diagnostic, it is possible to infer the plasma flow, particle flux, and heat flux at different locations along the plasma column in Proto-MPEX. Preliminary results show Mach numbers of 0.5 (towards the dump plate) and 1.0 (towards the target plate) downstream from the helicon source, and a stagnation point (no flow) near the source for the case where the peak magnetic field was 1.3 T. Measurements of particle flow and ne and Te profiles are discussed. The extensive coverage provided by these diagnostics permits data-constrained B2.5-Eirene modeling of the entire plasma column, and comparison with results of modeling in the high-density helicon plasmas will be presented.

  18. Getting to the Outer Leaflet: Physiology of Phosphatidylserine Exposure at the Plasma Membrane.

    Science.gov (United States)

    Bevers, Edouard M; Williamson, Patrick L

    2016-04-01

    Phosphatidylserine (PS) is a major component of membrane bilayers whose change in distribution between inner and outer leaflets is an important physiological signal. Normally, members of the type IV P-type ATPases spend metabolic energy to create an asymmetric distribution of phospholipids between the two leaflets, with PS confined to the cytoplasmic membrane leaflet. On occasion, membrane enzymes, known as scramblases, are activated to facilitate transbilayer migration of lipids, including PS. Recently, two proteins required for such randomization have been identified: TMEM16F, a scramblase regulated by elevated intracellular Ca(2+), and XKR8, a caspase-sensitive protein required for PS exposure in apoptotic cells. Once exposed at the cell surface, PS regulates biochemical reactions involved in blood coagulation, and bone mineralization, and also regulates a variety of cell-cell interactions. Exposed on the surface of apoptotic cells, PS controls their recognition and engulfment by other cells. This process is exploited by parasites to invade their host, and in specialized form is used to maintain photoreceptors in the eye and modify synaptic connections in the brain. This review discusses what is known about the mechanism of PS exposure at the surface of the plasma membrane of cells, how actors in the extracellular milieu sense surface exposed PS, and how this recognition is translated to downstream consequences of PS exposure. Copyright © 2016 the American Physiological Society.

  19. Plasma data analysis using statistical analysis system

    International Nuclear Information System (INIS)

    Yoshida, Z.; Iwata, Y.; Fukuda, Y.; Inoue, N.

    1987-01-01

    Multivariate factor analysis has been applied to a plasma data base of REPUTE-1. The characteristics of the reverse field pinch plasma in REPUTE-1 are shown to be explained by four independent parameters which are described in the report. The well known scaling laws F/sub chi/ proportional to I/sub p/, T/sub e/ proportional to I/sub p/, and tau/sub E/ proportional to N/sub e/ are also confirmed. 4 refs., 8 figs., 1 tab

  20. Performance analyses of Elmo Bumpy Torus plasmas and plasma support systems

    International Nuclear Information System (INIS)

    Fenstermacher, M.E.

    1979-01-01

    The development and applcation of the OASIS Code (Operational Analysis of ELMO Bumpy Torus Support and Ignition Systems) for the study of EBT device and plasma performance are presented. The code performs a time-independent, zero-dimensional self-consistent calculation of plasma and plasmasupport systems parameters for the physics and engineering of EBT devices. The features of OASIS modeling for the EBT plasma include: (1) particle balance of the bulk toroidal and electron ring plasma components for experimental (H-H, D-D, He-He etc.) as well as reactor (D-T) devices; (2) energy balance in the bulk and ring plasmas for externally heated or ignition devices; (3) alpha particle effects for reactor devices; (4) auxiliary heating effects, including microwave (ECRH), RF heating (e.g., ICRH), and neutral beam methods; and (5) ignition conditions, including fusion power, alpha power and neutron wall loading. The performance studies using OASIS focussed on variation in plasma and device size and on microwave input power and frequency. An additional study was performed to determine the characteristics of an EBT reactor proof-of-principle device operated with a deuterium-tritium plasma. Sensitivity studies were performed for variation in the input microwave power sharing fractions and the dependence of the bulk n tau scaling law on bulk electron temperature

  1. Plasma flow in toroidal systems with a separatrix

    International Nuclear Information System (INIS)

    Gribkov, V.M.; Morozov, D.Kh.; Pogutse, O.P.

    1984-01-01

    A hydrodynamic plasma flow in toroidal systems is considered. Rlasma flow lines for various magnetic configurations are calculated. A particular attention is given to studying plasma flow in configurations with two magnetic a axes and a separatrix. The flow picture i the toroidal case is shown to qualita ity to penetrate through the separatrix - the latter becomes ''perforated''. Th he pictkre of these flows is calculated. The plasma diffusion coefficient with account for the separatrix is calculated and is shown not to turn into the infin nity in the toroidal case as well. The plasma flow is analytically considered in the model with distributed current as well as in the model with current conce entrated at the oroidal system axis. In the first case the existence of ''stagnant'' regions near the magnetic axis is established from which the plasma a does not flow out

  2. The change of β-adrenergic system after cessation of lead exposure

    International Nuclear Information System (INIS)

    Chang, H.-R.; Tsao, D.-A.; Yu, H.-S.; Ho, C.-K.

    2005-01-01

    For understanding a reversible or irreversible harm of β-adrenergic system in lead induced cardiovascular disease (hypertension), We set up animal model to estimate the change of blood pressure and sympathetic nervous system after lead exposure withdrawn in the study. We address three topics in this study: (a) the relationship between withdrawal time of lead exposure and β-adrenergic receptor, plasma catecholamine level, blood pressure, and lead level in heart, aorta, and kidney in lead-induced hypertensive rats after lead exposure stopped; (b) the relationship between blood pressure and β-adrenergic receptor in heart, aorta, and kidney; (c) the estimation of relationship between lead withdrawn and the variation of β-adrenergic system. Wistar rats were chronically fed with 2% lead acetate (experimental group) and water (control group) for 2 months. The rats were divided into 8 groups by withdrawal time of lead exposure stopped. Plasma catecholamine level was measured by high-performance liquid chromatography. Radioligand binding assay was measured by a method that fulfilled strict criteria of β-adrenergic receptor using the ligand [ 125 I]iodocyanopindolol. The levels of lead were determined by electrothermal atomic absorption spectrometry. The results showed that a close relation between reduced lead level and the plasma catecholamine level decreased, aorta β-adrenergic receptor increased, kidney β-adrenergic receptor diminished, heart β-adrenergic receptor increased, and blood pressure dropped after lead exposure withdrawn. The study on the regulation of β-adrenergic system in lead-induced hypertension after lead withdrawn might also provide insight about the nature of this disease state

  3. System and method of plasma particle separation

    International Nuclear Information System (INIS)

    Schmidt, G.; Halpern, G.M.; Thomas, W.R.L.

    1975-01-01

    Several examples of the design are described to ionize flowing uranium or UF 6 vapour through laser beam and to conduct the thus produced flowing plasma into the region of a magnetic field gradient separating the isotopes. (GG/LH) [de

  4. Growth of carbon allotropes and plasma characterization in linear antenna microwave plasma CVD system

    Czech Academy of Sciences Publication Activity Database

    Potocký, Štěpán; Babchenko, Oleg; Davydova, Marina; Ižák, Tibor; Čada, Martin; Kromka, Alexander

    2014-01-01

    Roč. 53, č. 5 (2014), "05FP04-1"-"05FP04-3" ISSN 0021-4922 R&D Projects: GA TA ČR TA01011740; GA ČR GAP205/12/0908 Grant - others:AVČR(CZ) M100100902 Institutional support: RVO:68378271 Keywords : antenna linear * CVD system * plasma Subject RIV: BL - Plasma and Gas Discharge Physics Impact factor: 1.127, year: 2014

  5. Nanoindentation study of the combined effects of crystallography, heat treatment and exposure to high-flux deuterium plasma in tungsten

    Energy Technology Data Exchange (ETDEWEB)

    Zayachuk, Y., E-mail: yevhen.zayachuk@materials.ox.ac.uk [Department of Materials, University of Oxford, Parks Road, Oxford OX1 3PH (United Kingdom); Culham Centre for Fusion Energy, Culham Science Centre, Abingdon OX14 3DB (United Kingdom); Armstrong, D.E.J. [Department of Materials, University of Oxford, Parks Road, Oxford OX1 3PH (United Kingdom); Bystrov, K. [FOM Institute DIFFER- Dutch Institute for Fundamental Energy Research, Trilateral Euregio Cluster, De Zaale 20, 3612 AJ Eindhoven (Netherlands); Van Boxel, S. [Culham Centre for Fusion Energy, Culham Science Centre, Abingdon OX14 3DB (United Kingdom); Morgan, T. [FOM Institute DIFFER- Dutch Institute for Fundamental Energy Research, Trilateral Euregio Cluster, De Zaale 20, 3612 AJ Eindhoven (Netherlands); Roberts, S.G. [Department of Materials, University of Oxford, Parks Road, Oxford OX1 3PH (United Kingdom); Culham Centre for Fusion Energy, Culham Science Centre, Abingdon OX14 3DB (United Kingdom)

    2017-04-01

    tungsten samples were heat-treated to achieve partial recrystallization and exposed to high ion flux deuterium plasma at different temperatures and fluences. Continuous stiffness nanoindentation measurements of near-surface hardness were performed in the grains of specific annealing states and of specific crystallographic orientation, determined by electron backscatter diffraction (EBSD); indentation pile-up was investigated using surface profilometry. Bulk hardness of unexposed tungsten does not strongly depend on grain orientation, but depends on the annealing state of the grain, with values between ∼4.3 GPa for recrystallized grains and ∼5.5 for non-recrystallized ones. Grains with <111> surface normal orientation feature the least pile-up, while grains with <001> orientation the most; pile-up also depends on the annealing state, being generally lower in recrystallized grains. Plasma exposure leads to the increase of hardness, most significantly near the surface. The width of plasma-affected zone increases with the increase of exposure temperature and fluence, as well in recrystallized grains, correlating with the increase of diffusion depth. Plasma exposure does not lead to the emergence of orientation-dependence of hardness. Both indentation pile-up and near-surface indentation pop-ins are generally suppressed by plasma exposure.

  6. Transformation instability of oscillations in inhomogeneous beam-plasma system

    International Nuclear Information System (INIS)

    Kitsenko, A.B.

    1985-01-01

    Wave transformation is studied in a plasma system which was weak-inhomogeneous along beam velocity, in absence of external magnetic field. For the case of small density beam formulae are obtained which have set a coupling between the charge density beam wave amplitudes and the Langmuir wave on both sides of transformation point. It is shown that in collisionless plasma the wave production is a cause of the absorption of the charge density beam waves. Transformation mechanism of the absolute instability in the weak-inhomogeneous beam-plasma system is revealed

  7. Plasma-liquid system with rotational gliding discharge with liquid electrode

    International Nuclear Information System (INIS)

    Nedybaliuk, O.A.; Solomenko, O.V; Martysh, E.V.; Fedirchuk, I.I.

    2014-01-01

    Plasma-liquid system based on rotational gliding discharge with one liquid electrode was developed. Emission spectra of plasma of rotational gliding discharge with one liquid electrode were investigated. Discovered effective mechanism of controlling non-isothermal level of plasma in dynamic plasma-liquid systems. Major mechanism of expulsion of metal anode material from plasma-liquid systems with rotational discharges was shown.

  8. Presence in Virtual Reality Exposure Therapy Systems

    NARCIS (Netherlands)

    Ling, Y.

    2014-01-01

    Experiencing anxiety is essential for virtual reality exposure therapy (VRET) to be effective in curing patients suffering from anxiety disorders. However, some patients drop out in VRET due to the lack of feeling anxiety. Presence - which refers to the feeling of being in the virtual environment -

  9. Progress and plan of KSTAR plasma control system upgrade

    Energy Technology Data Exchange (ETDEWEB)

    Hahn, Sang-hee, E-mail: hahn76@nfri.re.kr [National Fusion Research Institute, Daejeon (Korea, Republic of); Kim, Y.J. [National Fusion Research Institute, Daejeon (Korea, Republic of); Penaflor, B.G. [General Atomics, San Diego, CA (United States); Bak, J.G.; Han, H.; Hong, J.S.; Jeon, Y.M.; Jeong, J.H.; Joung, M.; Juhn, J.W.; Kim, J.S.; Kim, H.S.; Lee, W.R.; Woo, M.H. [National Fusion Research Institute, Daejeon (Korea, Republic of); Eidietis, N.W.; Ferron, J.R.; Humphreys, D.A.; Hyatt, A.; Johnson, R.D.; Piglowski, D.A. [General Atomics, San Diego, CA (United States); and others

    2016-11-15

    Highlights: • Recent achievements of the KSTAR plasma control system are described. • Requirements and results of the testbed system for the future upgrade of the KSTAR plasma control system are presented. • An overview of the upgrade layout based is given. - Abstract: The plasma control system (PCS) has been one of essential systems in annual KSTAR plasma campaigns: starting from a single-process version in 2008, extensive upgrades are done through the previous 7 years in order to achieve major goals of KSTAR performance enhancement. Major implementations are explained in this paper. In consequences of successive upgrades, the present KSTAR PCS is able to achieve ∼48 s of 500 kA plasma pulses with full real-time shaping controls and real-time NB power controls. It has become a huge system capable of dealing with 8 separate categories of algorithms, 26 actuators directly controllable during the shot, and real-time data communication units consisting of +180 analog channels and +600 digital input/outputs through the reflective memory (RFM) network. The next upgrade of the KSTAR PCS is planned in 2015 before the campaign. An overview of the upgrade layout will be given for this paper. The real-time system box is planned to use the CERN MRG-Realtime OS, an ITER-compatible standard operating system. New hardware is developed for faster real-time streaming system for future installations of actuators/diagnostics.

  10. Cold Atmospheric Plasma Manipulation of Proteins in Food Systems

    DEFF Research Database (Denmark)

    Tolouie, Haniye; Hashemi, Maryam; Mohammadifar, Mohammad Amin

    2017-01-01

    Plasma processing has been getting a lot of attention in recent applications as a novel, eco-friendly, and highly efficient approach. Cold plasma has mostly been used to reduce microbial counts in foodstuff and biological materials, as well as in different levels of packaging, particularly in cases...... of plasma on the conformation and function of proteins with food origin, especially enzymes and allergens, as well as protein-made packaging films. In enzyme manipulation with plasma, deactivation has been reported to be either partial or complete. In addition, an activity increase has been observed in some...... where there is thermal sensitivity. As it is a very recent application, the impact of cold plasma treatment has been studied on the protein structures of food and pharmaceutical systems, as well as in the packaging industry. Proteins, as a food constituent, play a remarkable role in the techno...

  11. Plasma sources of solar system magnetospheres

    CERN Document Server

    Blanc, Michel; Chappell, Charles; Krupp, Norbert

    2016-01-01

    This volume reviews what we know of the corresponding plasma source for each intrinsically magnetized planet. Plasma sources fall essentially in three categories: the solar wind, the ionosphere (both prevalent on Earth), and the satellite-related sources. Throughout the text, the case of each planet is described, including the characteristics, chemical composition and intensity of each source. The authors also describe how the plasma generated at the source regions is transported to populate the magnetosphere, and how it is later lost. To summarize, the dominant sources are found to be the solar wind and sputtered surface ions at Mercury, the solar wind and ionosphere at Earth (the relative importance of the two being discussed in a specific introductory chapter), Io at Jupiter and – a big surprise of the Cassini findings – Enceladus at Saturn. The situation for Uranus and Neptune, which were investigated by only one fly-by each, is still open and requires further studies and exploration. In the final cha...

  12. Sub-surface microstructure of single and polycrystalline tungsten after high flux plasma exposure studied by TEM

    Energy Technology Data Exchange (ETDEWEB)

    Dubinko, A., E-mail: adubinko@sckcen.be [Institute for Nuclear Material Sciences, SCK-CEN, 2400 Mol (Belgium); Department of Applied Physics, Ghent University, 9000 Ghent (Belgium); Terentyev, D. [Institute for Nuclear Material Sciences, SCK-CEN, 2400 Mol (Belgium); Bakaeva, A. [Institute for Nuclear Material Sciences, SCK-CEN, 2400 Mol (Belgium); Department of Applied Physics, Ghent University, 9000 Ghent (Belgium); Hernández-Mayoral, M. [Division of Materials, CIEMAT, 28040 Madrid (Spain); De Temmerman, G. [ITER Organization, Route de Vinon-sur-Verdon, CS 90 046, 13067 St Paul-lez-Durance Cedex (France); Buzi, L. [Forschungszentrum Julich, Inst. Energie & Klimaforsch Plasmaphys, D-52425 Julich (Germany); Noterdaeme, J.-M. [Department of Applied Physics, Ghent University, 9000 Ghent (Belgium); Unterberg, B. [Forschungszentrum Julich, Inst. Energie & Klimaforsch Plasmaphys, D-52425 Julich (Germany)

    2017-01-30

    Highlights: • Plasma exposure induces dislocation-dominated microstructure as indicated by TEM. • Plasma exposure increases surface dislocation density by an order of magnitude in the polycrystalline tungsten. • Intensive dislocation-grain boundary interaction observed in polycrystalline tungsten. • Dislocation loops are observed in both polycrystalline and single crystal tungsten. - Abstract: We have performed high flux plasma exposure of tungsten and subsequent microstructural characterization using transmission electron microscopy (TEM) techniques. The aim was to reveal the nanometric features in the sub-surface region as well as to compare the microstructural evolution in tungsten single crystal and ITER-relevant specification. In both types of samples, TEM examination revealed the formation of a dense dislocation network and dislocation tangles. The estimated dislocation density in the sub-surface region was of the order of 10{sup 14} m{sup −2} and it gradually decreased with a depth position of the examined sample. Besides individual dislocation lines, networks and tangles, the interstitial dislocation loops have been observed in all examined samples only after the exposure. Contrary to that, examination of the pristine single crystal W and backside of the plasma-exposed samples did not reveal the presence of dislocation loops and tangles. This clearly proves that high flux plasma exposure induces severe plastic deformation in the sub-surface region irrespective of the presence of initial dislocations and sub-grains, and the formation of dislocation tangles, networks and interstitial loops is a co-product of thermal stress and intensive plasma particles uptake.

  13. Effect of 'PC Game Room' use and polycyclic aromatic hydrocarbon exposure on plasma testosterone concentrations in young male Koreans.

    Science.gov (United States)

    Kim, Heon; Kang, Jong-Won; Ku, Seung-Yup; Kim, Seok Hyun; Cho, Soo-Hun; Koong, Sung-Soo; Kim, Yong-Dae; Lee, Chul-Ho

    2005-03-01

    'PC Game Rooms' were first popularized in Korea, although the concept is now becoming popular worldwide. PC Game Rooms provide users with high-performance PC connected to the high-speed internet, and access to computer games. However, PC Game Room users are exposed to various hazardous agents such as cigarette smoke in a confined environment, and thus it is likely that excessive PC Game Room use involves abnormal exposure to polycyclic aromatic hydrocarbons (PAH) as well as being associated with disturbed sleep or circadian rhythm. In this cross-sectional study, the exposure to PAH was evaluated by measuring urinary 1-hydroxypyrene (1-OHP) and 2-naphthol. The correlations between PC Game Room use and PAH exposure and plasma testosterone and LH levels were analysed in 208 young male Koreans. Urinary 1-OHP concentrations increased (P = 0.0001) and plasma testosterone levels decreased (P = 0.0153) significantly with increased duration of PC Game Room use. Correlation analysis showed that plasma testosterone concentrations were significantly negatively correlated with urinary 1-OHP (r = -0.22, P = 0.0012) and 2-naphthol (r = -0.15, P = 0.0308) concentrations. Moreover, these associations persisted after adjusting for other independent variables. However, the duration of PC Game Room use itself was not found to be an independent significant determinant of plasma testosterone level. Rather, PC Game Room use increased PAH exposure, which decreased plasma testosterone level. The younger age group (15-19 years) showed a more prominent decrease in plasma testosterone concentrations with increasing duration of PC Game Room use than the older age group (20-24 years) (r2 = 0.355, P = 0.0301 versus r2 = 0.213, P = 0.0001). These results imply that the excessive use of PC Game Rooms is related to an adverse impact on sex hormonal status in young male Koreans via PAH exposure. This effect was more prominent in the younger age group.

  14. Substrate Effect on Plasma Clean Efficiency in Plasma Enhanced Chemical Vapor Deposition System

    Directory of Open Access Journals (Sweden)

    Shiu-Ko JangJian

    2007-01-01

    Full Text Available The plasma clean in a plasma-enhanced chemical vapor deposition (PECVD system plays an important role to ensure the same chamber condition after numerous film depositions. The periodic and applicable plasma clean in deposition chamber also increases wafer yield due to less defect produced during the deposition process. In this study, the plasma clean rate (PCR of silicon oxide is investigated after the silicon nitride deposited on Cu and silicon oxide substrates by remote plasma system (RPS, respectively. The experimental results show that the PCR drastically decreases with Cu substrate compared to that with silicon oxide substrate after numerous silicon nitride depositions. To understand the substrate effect on PCR, the surface element analysis and bonding configuration are executed by X-ray photoelectron spectroscopy (XPS. The high resolution inductively coupled plasma mass spectrometer (HR-ICP-MS is used to analyze microelement of metal ions on the surface of shower head in the PECVD chamber. According to Cu substrate, the results show that micro Cu ion and the CuOx bonding can be detected on the surface of shower head. The Cu ion contamination might grab the fluorine radicals produced by NF3 ddissociation in the RPS and that induces the drastic decrease on PCR.

  15. Electrode assemblies, plasma apparatuses and systems including electrode assemblies, and methods for generating plasma

    Science.gov (United States)

    Kong, Peter C; Grandy, Jon D; Detering, Brent A; Zuck, Larry D

    2013-09-17

    Electrode assemblies for plasma reactors include a structure or device for constraining an arc endpoint to a selected area or region on an electrode. In some embodiments, the structure or device may comprise one or more insulating members covering a portion of an electrode. In additional embodiments, the structure or device may provide a magnetic field configured to control a location of an arc endpoint on the electrode. Plasma generating modules, apparatus, and systems include such electrode assemblies. Methods for generating a plasma include covering at least a portion of a surface of an electrode with an electrically insulating member to constrain a location of an arc endpoint on the electrode. Additional methods for generating a plasma include generating a magnetic field to constrain a location of an arc endpoint on an electrode.

  16. Presence in Virtual Reality Exposure Therapy Systems

    OpenAIRE

    Ling, Y.

    2014-01-01

    Experiencing anxiety is essential for virtual reality exposure therapy (VRET) to be effective in curing patients suffering from anxiety disorders. However, some patients drop out in VRET due to the lack of feeling anxiety. Presence - which refers to the feeling of being in the virtual environment - has been considered an important mechanism that leads to the experience of anxiety. Therefore, understanding the relationship between presence and anxiety and finding ways to improve presence in VR...

  17. Continuous, saturation, and discontinuous tokamak plasma vertical position control systems

    Energy Technology Data Exchange (ETDEWEB)

    Mitrishkin, Yuri V., E-mail: y_mitrishkin@hotmail.com [M. V. Lomonosov Moscow State University, Faculty of Physics, Moscow 119991 (Russian Federation); Pavlova, Evgeniia A., E-mail: janerigoler@mail.ru [M. V. Lomonosov Moscow State University, Faculty of Physics, Moscow 119991 (Russian Federation); Kuznetsov, Evgenii A., E-mail: ea.kuznetsov@mail.ru [Troitsk Institute for Innovation and Fusion Research, Moscow 142190 (Russian Federation); Gaydamaka, Kirill I., E-mail: k.gaydamaka@gmail.com [V. A. Trapeznikov Institute of Control Sciences of the Russian Academy of Sciences, Moscow 117997 (Russian Federation)

    2016-10-15

    Highlights: • Robust new linear state feedback control system for tokamak plasma vertical position. • Plasma vertical position relay control system with voltage inverter in sliding mode. • Design of full models of multiphase rectifier and voltage inverter. • First-order unit approximation of full multiphase rectifier model with high accuracy. • Wider range of unstable plant parameters of stable control system with multiphase rectifier. - Abstract: This paper is devoted to the design and comparison of unstable plasma vertical position control systems in the T-15 tokamak with the application of two types of actuators: a multiphase thyristor rectifier and a transistor voltage inverter. An unstable dynamic element obtained by the identification of plasma-physical DINA code was used as the plasma model. The simplest static feedback state space control law was synthesized as a linear combination of signals accessible to physical measurements, namely the plasma vertical displacement, the current, and the voltage in a horizontal field coil, to solve the pole placement problem for a closed-loop system. Only one system distinctive parameter was used to optimize the performance of the feedback system, viz., a multiple real pole. A first-order inertial unit was used as the rectifier model in the feedback. A system with a complete rectifier model was investigated as well. A system with the voltage inverter model and static linear controller was brought into a sliding mode. As this takes place, real time delays were taken into account in the discontinuous voltage inverter model. The comparison of the linear and sliding mode systems showed that the linear system enjoyed an essentially wider range of the plant model parameters where the feedback system was stable.

  18. Continuous, saturation, and discontinuous tokamak plasma vertical position control systems

    International Nuclear Information System (INIS)

    Mitrishkin, Yuri V.; Pavlova, Evgeniia A.; Kuznetsov, Evgenii A.; Gaydamaka, Kirill I.

    2016-01-01

    Highlights: • Robust new linear state feedback control system for tokamak plasma vertical position. • Plasma vertical position relay control system with voltage inverter in sliding mode. • Design of full models of multiphase rectifier and voltage inverter. • First-order unit approximation of full multiphase rectifier model with high accuracy. • Wider range of unstable plant parameters of stable control system with multiphase rectifier. - Abstract: This paper is devoted to the design and comparison of unstable plasma vertical position control systems in the T-15 tokamak with the application of two types of actuators: a multiphase thyristor rectifier and a transistor voltage inverter. An unstable dynamic element obtained by the identification of plasma-physical DINA code was used as the plasma model. The simplest static feedback state space control law was synthesized as a linear combination of signals accessible to physical measurements, namely the plasma vertical displacement, the current, and the voltage in a horizontal field coil, to solve the pole placement problem for a closed-loop system. Only one system distinctive parameter was used to optimize the performance of the feedback system, viz., a multiple real pole. A first-order inertial unit was used as the rectifier model in the feedback. A system with a complete rectifier model was investigated as well. A system with the voltage inverter model and static linear controller was brought into a sliding mode. As this takes place, real time delays were taken into account in the discontinuous voltage inverter model. The comparison of the linear and sliding mode systems showed that the linear system enjoyed an essentially wider range of the plant model parameters where the feedback system was stable.

  19. Effects of acute exposure to increased plasma branched-chain amino acid concentrations on insulin-mediated plasma glucose turnover in healthy young subjects.

    Science.gov (United States)

    Everman, Sarah; Mandarino, Lawrence J; Carroll, Chad C; Katsanos, Christos S

    2015-01-01

    Plasma branched-chain amino acids (BCAA) are inversely related to insulin sensitivity of glucose metabolism in humans. However, currently, it is not known whether there is a cause-and-effect relationship between increased plasma BCAA concentrations and decreased insulin sensitivity. To determine the effects of acute exposure to increased plasma BCAA concentrations on insulin-mediated plasma glucose turnover in humans. Ten healthy subjects were randomly assigned to an experiment where insulin was infused at 40 mU/m2/min (40U) during the second half of a 6-hour intravenous infusion of a BCAA mixture (i.e., BCAA; N = 5) to stimulate plasma glucose turnover or under the same conditions without BCAA infusion (Control; N = 5). In a separate experiment, seven healthy subjects were randomly assigned to receive insulin infusion at 80 mU/m2/min (80U) in association with the above BCAA infusion (N = 4) or under the same conditions without BCAA infusion (N = 3). Plasma glucose turnover was measured prior to and during insulin infusion. Insulin infusion completely suppressed the endogenous glucose production (EGP) across all groups. The percent suppression of EGP was not different between Control and BCAA in either the 40U or 80U experiments (P > 0.05). Insulin infusion stimulated whole-body glucose disposal rate (GDR) across all groups. However, the increase (%) in GDR was not different [median (1st quartile - 3rd quartile)] between Control and BCAA in either the 40U ([199 (167-278) vs. 186 (94-308)] or 80 U ([491 (414-548) vs. 478 (409-857)] experiments (P > 0.05). Likewise, insulin stimulated the glucose metabolic clearance in all experiments (P BCAA in either of the experiments (P > 0.05). Short-term exposure of young healthy subjects to increased plasma BCAA concentrations does not alter the insulin sensitivity of glucose metabolism.

  20. Effects of acute exposure to increased plasma branched-chain amino acid concentrations on insulin-mediated plasma glucose turnover in healthy young subjects.

    Directory of Open Access Journals (Sweden)

    Sarah Everman

    Full Text Available Plasma branched-chain amino acids (BCAA are inversely related to insulin sensitivity of glucose metabolism in humans. However, currently, it is not known whether there is a cause-and-effect relationship between increased plasma BCAA concentrations and decreased insulin sensitivity.To determine the effects of acute exposure to increased plasma BCAA concentrations on insulin-mediated plasma glucose turnover in humans.Ten healthy subjects were randomly assigned to an experiment where insulin was infused at 40 mU/m2/min (40U during the second half of a 6-hour intravenous infusion of a BCAA mixture (i.e., BCAA; N = 5 to stimulate plasma glucose turnover or under the same conditions without BCAA infusion (Control; N = 5. In a separate experiment, seven healthy subjects were randomly assigned to receive insulin infusion at 80 mU/m2/min (80U in association with the above BCAA infusion (N = 4 or under the same conditions without BCAA infusion (N = 3. Plasma glucose turnover was measured prior to and during insulin infusion.Insulin infusion completely suppressed the endogenous glucose production (EGP across all groups. The percent suppression of EGP was not different between Control and BCAA in either the 40U or 80U experiments (P > 0.05. Insulin infusion stimulated whole-body glucose disposal rate (GDR across all groups. However, the increase (% in GDR was not different [median (1st quartile - 3rd quartile] between Control and BCAA in either the 40U ([199 (167-278 vs. 186 (94-308] or 80 U ([491 (414-548 vs. 478 (409-857] experiments (P > 0.05. Likewise, insulin stimulated the glucose metabolic clearance in all experiments (P 0.05.Short-term exposure of young healthy subjects to increased plasma BCAA concentrations does not alter the insulin sensitivity of glucose metabolism.

  1. Simultaneous Control of Phenanthrene and Drought by Dual Exposure System

    DEFF Research Database (Denmark)

    Schmidt, Stine N.; Holmstrup, Martin; Damgaard, Christian

    2014-01-01

    Organisms in the environment are exposed to multiple stressors. However, for terrestrial invertebrates, it remains difficult to study the effects of combined stressors under well-defined exposure conditions. Thus, the current study develops a new dual exposure system for the simultaneous...... set revealed statistically significant synergy between phenanthrene and drought (p account when...

  2. Plasma surface interactions in Q-enhanced mirror systems

    International Nuclear Information System (INIS)

    Post, R.F.

    1978-01-01

    Two approaches to enhancement of the Q (energy gain) factor of mirror systems are under study at Livermore. These include the Tandem Mirror and the Field Reversed Mirror. Both of these new ideas preserve features of conventional mirror systems as far as plasma-wall interactions are concerned. Specifically in both approaches field lines exit from the ends of the system and impinge on walls located at a distance from the confinement chamber. It is possible to predict some aspects of the plasma/surface interactions of TM and FRM systems from experience obtained in the Livermore 2XIIB experiment. In particular, as observed in 2XIIB, effective isolation of the plasma from thermal contact with the ends owing to the development of sheath-like regions is to be expected. Studies presently underway directed toward still further enhancing the decoupling of the plasma from the effects of plasma surface interactions at the walls will be discussed, with particular reference to the problem of minimizing the effects of refluxing secondary electrons produced by plasma impact on the end walls

  3. A plasma melting system for solid radioactive waste

    International Nuclear Information System (INIS)

    Higashi, Yasuo; Sugimoto, Masahiko; Fujitomi, Masashi; Noura, Tsuyoshi

    2003-01-01

    Kobe Steel has developed a plasma melting system for the volume reduction and stabilization of solid radioactive wastes such as concrete, insulation, filters, glass, sand etc. The main features of the system are as follows. (1) Non-transfer air plasma torches: 1.3 MW x 2 (2) Treatment capacity: 2 tons/batch (3) Waste feed: 200 liter drums (4) Tapping method: furnace tilting (5) Molten slag cooling: in the system's chambers. In this paper, an outline of the system and its first-run performance results are described. (author)

  4. Effects of chronic exposure to ethanol on the physical and functional properties of the plasma membrane of S49 lymphoma cells

    International Nuclear Information System (INIS)

    Bode, D.C.; Molinoff, P.B.

    1988-01-01

    The effects of chronic exposure to ethanol on the physical and functional properties of the plasma membrane were examined with cultured S49 lymphoma cells. The β-adrenergic receptor-coupled adenylate cyclase system was used as a probe of the functional properties of the plasma membrane. Steady-state fluorescence anisotropy of diphenylhexatriene and the lipid composition of the plasma membrane were used as probes of the physical properties of the membrane. Cells were grown under conditions such that the concentration of ethanol in the growth medium remained stable and oxidation of ethanol to acetaldehyde was not detected. Chronic exposure of S49 cells to 50 mM ethanol or growth of cells at elevated temperature resulted in a decrease in adenylate cyclase activity. There were no changes in the density of receptors or in the affinity of β-adrenergic receptors for agonists or antagonists following chronic exposure to ethanol. The fluorescence anisotropy of diphenylhexatriene was lower in plasma membranes prepared from cells that had been treated with 50 mM ethanol than in membranes prepared from control cells. However, this change was not associated with changes in the fatty acid composition or the cholesterol to phospholipid ratio of the plasma membrane. There was a small but statistically significant decrease in the amount of phosphatidylserine and an increase in the amount of phosphatidylethanolamine. These changes cannot account for the decrease in anisotropy. In contrast to the effect of ethanol, a decrease in adenylate cyclase activity following growth of S49 cells at 40 0 C was not associated with a change in anisotropy

  5. Real-time personal exposure and health condition monitoring system

    Energy Technology Data Exchange (ETDEWEB)

    Saitou, Isamu; Kanda, Hiroaki; Asai, Akio; Takeishi, Naoki; Ota, Yoshito [Hitachi Aloka Medical, Ltd., Measuring Systems Engineering Dept., Tokyo (Japan); Hanawa, Nobuhiro; Ueda, Hisao; Kusunoki, Tsuyoshi; Ishitsuka, Etsuo; Kawamura, Hiroshi [Japan Atomic Energy Agency, Oarai Research and Development Center, Oarai, Ibaraki (Japan)

    2012-03-15

    JAEA (Japan Atomic Energy Agency) and HAM (Hitachi Aloka Medical, Ltd) have proposed novel monitoring system for workers of nuclear facility. In these facilities, exposure management for workers is mainly used access control and personal exposure recordings. This system is currently only for reports management but is not confirmative for surveillance when work in progress. Therefore, JAEA and HAM integrate access control and personal exposure recordings and two real-time monitoring systems which are position sensing and vital sign monitor. Furthermore change personal exposure management to real-time management, this system integration prevents workers from risk of accidents, and makes possible take appropriate action quickly. This novel system is going to start for tentative operation, using position sensing and real-time personal dosimeter with database in Apr. 2012. (author)

  6. Time course of systemic oxidative stress and inflammatory response induced by an acute exposure to Residual Oil Fly Ash

    Energy Technology Data Exchange (ETDEWEB)

    Marchini, T.; Magnani, N.D. [Cátedra de Química General e Inorgánica, Instituto de Bioquímica y Medicina Molecular (IBIMOL UBA-CONICET), Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 954, C1113AAB Buenos Aires (Argentina); Paz, M.L. [Cátedra de Inmunología, Instituto de Estudios de la Inmunidad Humoral (IDEHU UBA-CONICET), Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 954, C1113AAB Buenos Aires (Argentina); Vanasco, V. [Cátedra de Química General e Inorgánica, Instituto de Bioquímica y Medicina Molecular (IBIMOL UBA-CONICET), Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 954, C1113AAB Buenos Aires (Argentina); Tasat, D. [CESyMA, Facultad de Ciencia Tecnología, Universidad Nacional de General San Martín, Martín de Irigoyen 3100, 1650 San Martín, Buenos Aires (Argentina); González Maglio, D.H. [Cátedra de Inmunología, Instituto de Estudios de la Inmunidad Humoral (IDEHU UBA-CONICET), Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 954, C1113AAB Buenos Aires (Argentina); and others

    2014-01-15

    It is suggested that systemic oxidative stress and inflammation play a central role in the onset and progression of cardiovascular diseases associated with the exposure to particulate matter (PM). The aim of this work was to evaluate the time changes of systemic markers of oxidative stress and inflammation, after an acute exposure to Residual Oil Fly Ash (ROFA). Female Swiss mice were intranasally instilled with a ROFA suspension (1.0 mg/kg body weight) or saline solution, and plasma levels of oxidative damage markers [thiobarbituric acid reactive substances (TBARSs) and protein carbonyls], antioxidant status [reduced (GSH) and oxidized (GSSG) glutathione, ascorbic acid levels, and superoxide dismutase (SOD) activity], cytokines levels, and intravascular leukocyte activation were evaluated after 1, 3 or 5 h of exposure. Oxidative damage to lipids and decreased GSH/GSSG ratio were observed in ROFA-exposed mice as early as 1 h. Afterwards, increased protein oxidation, decreased ascorbic acid content and SOD activity were found in this group at 3 h. The onset of an adaptive response was observed at 5 h after the ROFA exposure, as indicated by decreased TBARS plasma content and increased SOD activity. The observed increase in oxidative damage to plasma macromolecules, together with systemic antioxidants depletion, may be a consequence of a systemic inflammatory response triggered by the ROFA exposure, since increased TNF-α and IL-6 plasma levels and polymorphonuclear leukocytes activation was found at every evaluated time point. These findings contribute to the understanding of the increase in cardiovascular morbidity and mortality, in association with environmental PM inhalation. - Highlights: • An acute exposure to ROFA triggers the occurrence of systemic oxidative stress. • Changes in plasmatic oxidative stress markers appear as early as 1 h after exposure. • ROFA induces proinflammatory cytokines release and intravascular leukocyte activation. • PMN

  7. High exposure to nevirapine in plasma is associated with an improved virological response in HIV-1-infected individuals

    NARCIS (Netherlands)

    Veldkamp, A. I.; Weverling, G. J.; Lange, J. M.; Montaner, J. S.; Reiss, P.; Cooper, D. A.; Vella, S.; Hall, D.; Beijnen, J. H.; Hoetelmans, R. M.

    2001-01-01

    OBJECTIVE: To explore relationships between exposure to nevirapine and the virological response in HIV-1-infected individuals participating in the INCAS trial. METHODS: The elimination rate constant of plasma HIV-1 RNA (k) was calculated during the first 2 weeks of treatment with nevirapine,

  8. The plasma movie database system for JT-60

    International Nuclear Information System (INIS)

    Sueoka, Michiharu; Kawamata, Yoichi; Kurihara, Kenichi; Seki, Akiyuki

    2007-01-01

    The real-time plasma movie with the computer graphics (CG) of plasma shape is one of the most effective methods to know what discharge have been made in the experiment. For an easy use of the movie in the data analysis, we have developed the plasma movie database system (PMDS), which automatically records plasma movie according to the JT-60 discharge sequence, and transfers the movie files on request from the web site. The file is compressed to about 8 MB/shot small enough to be transferred within a few seconds through local area network (LAN). In this report, we describe the developed system from the technical point of view, and discuss a future plan on the basis of advancing video technology

  9. Applications of plasma core reactors to terrestrial energy systems

    International Nuclear Information System (INIS)

    Lantham, T.S.; Biancardi, F.R.; Rodgers, R.J.

    1974-01-01

    Plasma core reactors offer several new options for future energy needs in addition to space power and propulsion applications. Power extraction from plasma core reactors with gaseous nuclear fuel allows operation at temperatures higher than conventional reactors. Highly efficient thermodynamic cycles and applications employing direct coupling of radiant energy are possible. Conceptual configurations of plasma core reactors for terrestrail applications are described. Closed-cycle gas turbines, MHD systems, photo- and thermo-chemical hydrogen production processes, and laser systems using plasma core reactors as prime energy sources are considered. Cycle efficiencies in the range of 50 to 65 percent are calculated for closed-cycle gas turbine and MHD electrical generators. Reactor advantages include continuous fuel reprocessing which limits inventory of radioactive by-products and thorium-U-233 breeder configurations with about 5-year doubling times

  10. Development of personnel exposure management system with personal computer

    International Nuclear Information System (INIS)

    Yamato, Ichiro; Yamamoto, Toshiki

    1992-01-01

    In nuclear power plants, large scale personnel exposure management systems have been developed and established by utilities. Though being common in the base, the implementations are specific by plants. Contractors must control their workers' exposures by their own methods and systems. To comply with the utilities' parental systems, contractors' systems tend to differ by plants, thus make it difficult for contractors to design a standard system that is common to all relevant plants. Circumstances being as such, however, we have developed a system which is applicable to various customer utilities with minimal variations, using personal computers with database management and data communication softwares, with relatively low cost. We hope that this system will develop to the standard model for all Japanese contractors' personnel exposure management systems. (author)

  11. Plasma transport simulation modeling for helical confinement systems

    International Nuclear Information System (INIS)

    Yamazaki, K.; Amano, T.

    1991-08-01

    New empirical and theoretical transport models for helical confinement systems are developed based on the neoclassical transport theory including the effect of radial electric field and multi-helicity magnetic components, and the drift wave turbulence transport for electrostatic and electromagnetic modes, or the anomalous semi-empirical transport. These electron thermal diffusivities are compared with CHS (Compact Helical System) experimental data, which indicates that the central transport coefficient of the ECH plasma agrees with the neoclassical axi-symmetric value and the transport outside the half radius is anomalous. On the other hand, the transport of NBI-heated plasmas is anomalous in the whole plasma region. This anomaly is not explained by the electrostatic drift wave turbulence models in these flat-density-profile discharges. For the detailed prediction of plasma parameters in LHD (Large Helical Device), 3-D(dimensional) equilibrium/1-D transport simulations including empirical or drift wave turbulence models are carried out, which suggests that the global confinement time of LHD is determined mainly by the electron anomalous transport near the plasma edge region rather than the helical ripple transport in the core region. Even if the ripple loss can be eliminated, the increase of the global confinement is 10%. However, the rise in the central ion temperature is more than 20%. If the anomalous loss can be reduced to the half level of the present scaling, like so-called 'H-mode' of the tokamak discharge, the neoclassical ripple loss through the ion channel becomes important even in the plasma core. The 5% radial inward shift of the plasma column with respect to the major radius is effective for improving plasma confinement and raising more than 50% of the fusion product by reducing this neoclassical asymmetric ion transport loss and increasing 10% in the plasma radius. (author)

  12. Plasma transport simulation modelling for helical confinement systems

    International Nuclear Information System (INIS)

    Yamazaki, K.; Amano, T.

    1992-01-01

    New empirical and theoretical transport models for helical confinement systems are developed on the basis of the neoclassical transport theory, including the effect of the radial electric field and of multi-helicity magnetic components as well as the drift wave turbulence transport for electrostatic and electromagnetic modes or the anomalous semi-empirical transport. These electron thermal diffusivities are compared with experimental data from the Compact Helical System which indicate that the central transport coefficient of a plasma with electron cyclotron heating agrees with neoclassical axisymmetric value and the transport outside the half-radius is anomalous. On the other hand, the transport of plasmas with neutral beam injection heating is anomalous in the whole plasma region. This anomaly is not explained by the electrostatic drift wave turbulence models in these discharges with flat density profiles. For a detailed prediction of the plasma parameters in the Large Helical Device (LHD), 3-D equilibrium/1-D transport simulations including empirical or drift wave turbulence models are performed which suggest that the global confinement time of the LHD is determined mainly by the electron anomalous transport in the plasma edge region rather than by the helical ripple transport in the core region. Even if the ripple loss can be eliminated, the increase in global confinement is 10%. However, the rise in the central ion temperature is more than 20%. If the anomalous loss can be reduced to half of the value used in the present scaling, as is the case in the H-mode of tokamak discharges, the neoclassical ripple loss through the ion channel becomes important even in the plasma core. The 5% radial inward shift of the plasma column with respect to the major radius improves the plasma confinement and increases the fusion product by more than 50% by reducing the neoclassical asymmetric ion transport loss and increasing the plasma radius (10%). (author). 32 refs, 7 figs

  13. Development of Integrated Simulation System for Helical Plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Nakamura, Y.; Yokoyama, M.; Nakajima, N.; Fukuyama, A.; Watanabe, K. Y.; Funaba, H.; Suzuki, Y.; Murakami, S.; Ida, K.; Sakakibara, S.; Yamada, H.

    2005-07-01

    Recent progress of computers (parallel/vector-parallel computers, PC clusters, for example) and numerical codes for helical plasmas like three-dimensional MHD equilibrium codes, combined with the development of the plasma diagnostics technique, enable us to do the detailed theoretical analyses of the individual experimental observations. Now, it is pointed out that the experimental data analysis from the viewpoints of integrated physics is an important issue to understand the confinement physics globally. In addition to that, there are international movements towards the integrated numerical simulation study. One is several proposals of integrated modeling of burning tokamak plasmas, motivated by the ITER activity. The integrated numerical simulation will be a good help to draw up new experimental plans especially for burning plasma experiments. Another movement is international collaborations on the confinement database and neoclassical transport in helical plasmas/stellarators. These backgrounds motivate us to start the development of the integrated simulation system which has a modular structure and user-friendly interfaces. The integrated simulation system, which is based on the hierarchical and multi-scale (time and space) modeling, will also be a platform for theoreticians to test their own model such as turbulent transport model. In this paper, we will show the strategy of developing the integrated simulation system and present status of the development. Especially, we discuss the modeling of the time evolution of the plasma net current profile, which is equivalent to the time evolution of the rotational transform profile, in the resistive time scale. (Author)

  14. Systemic contact dermatitis after oral exposure to nickel

    DEFF Research Database (Denmark)

    Jensen, Christian Stab; Menné, Torkil; Johansen, Jeanne Duus

    2006-01-01

    Systemic contact dermatitis can be elicited experimentally in nickel-sensitive individuals by oral nickel exposure. A crucial point interpreting such experiments has been the relevance of nickel exposure from drinking water and diet. The aim of this meta-analysis study on former nickel......-exposure investigations was to provide the best possible estimation of threshold values of nickel doses that may cause systemic contact dermatitis in nickel-sensitive patients. 17 relevant investigations were identified, and statistical analyses were performed in a stepwise procedure. 9 studies were included in the final...... of the doses that, theoretically, would cause systemic contact dermatitis in exposed nickel-sensitive patients. The results from the 2 most sensitive groups show that 1% of these individuals may react with systemic contact dermatitis at normal daily nickel exposure from drinking water and diet, i.e. 0...

  15. Determination of plasma spot current and arc discharge plasma current on the system of plasma cathode electron sources using Rogowski coil technique

    International Nuclear Information System (INIS)

    Wirjoadi; Bambang Siswanto; Lely Susita RM; Agus Purwadi; Sudjatmoko

    2015-01-01

    It has been done the function test experiments of ignitor electrode system and the plasma generator electrode system to determine the current spot plasma and arc discharge plasma current with Rogowski coil technique. Ignitor electrode system that gets power supply from IDPS system can generate the plasma spot current of 11.68 ampere to the pulse width of about 33 μs, this value is greater than the design probably because of electronic components used in the IDPS system was not as planned. For the plasma generator electrode system that gets power from ADPS system capable of producing an arc discharge plasma current around 103.15 amperes with a pulse width of about 96 μs, and this value as planned. Based on the value of the arc discharge plasma current can be determined plasma electron density, which is about 10.12 10"1"9 electrons/m"3, and with this electron density value, an ignitor electrode system and a plasma generator system is quite good if used as a plasma cathode electron source system. (author)

  16. Beam-plasma interaction in case of injection of the electron beam to the symmetrically open plasma system

    International Nuclear Information System (INIS)

    Opanasenko, A.V.; Romanyuk, L.I.

    1992-01-01

    A beam-plasma interaction at the entrance of the symmetrically open plasma system with an electron beam injected through it is investigated. An ignition of the plasma-beam discharge on waves of upper hybrid dispersion branch of a magnetoactive plasma is found in the plasma penetrating into the vacuum contrary to the beam. It is shown that the beam-plasma discharge is localized in the inhomogeneous penetrating plasma in the zone where only these waves exist. Regularities of the beam-plasma discharge ignition and manifestation are described. It is determined that the electron beam crossing the discharge zone leads to the strong energy relaxation of the beam. It is shown possible to control the beam-plasma discharge ignition by changing the potential of the electron beam collector. (author)

  17. Grid system design on the plasma cathode electron source

    International Nuclear Information System (INIS)

    Agus Purwadi

    2014-01-01

    It has been designed the grid system on the Plasma Cathode Electron Source (PCES). Grid system with the electron emission hole of (15 x 60) cm 2 , the single aperture grid size of (0,5 x O,5) mm 2 and the grid wire diameter of 0,25 mm, will be used on the plasma generator chamber. If the sum of grid holes known and the value of electron emission current through every the grid hole known too then the total value of electron emission Current which emits from the plasma generator chamber can be determined It has been calculated the value of electron emission current I e as function of the grid radius r e =(0.28, 0.40, 0.49, 0.56, 0.63, 0.69) mm on the electron temperature of T e = 5 eV for varying of the value plasma electron densities n e = (10 15 , 10 16 , 10 17 , 10 18 ) m -3 . Also for the value of electron emission current fe as function of the grid radius r e = (0.28, 0.40, 0.49. 0.56, 0.63,0.69) mm on the electron density n e = 10 17 m -3 for varying of the value of plasma electron temperatures T e = (1, 2, 3, 4, 5) eV. electron emission current will be increase by increasing grid radius, electron temperature as well as plasma electron density. (author)

  18. Mass spectrometry profiling reveals altered plasma levels of monohydroxy fatty acids and related lipids in healthy humans after controlled exposure to biodiesel exhaust.

    Science.gov (United States)

    Gouveia-Figueira, Sandra; Karimpour, Masoumeh; Bosson, Jenny A; Blomberg, Anders; Unosson, Jon; Sehlstedt, Maria; Pourazar, Jamshid; Sandström, Thomas; Behndig, Annelie F; Nording, Malin L

    2018-08-14

    Experimental human exposure studies are an effective tool to study adverse health effects from acute inhalation of particulate matter and other constituents of air pollution. In this randomized and double-blinded crossover study, we investigated the systemic effect on bioactive lipid metabolite levels after controlled biodiesel exhaust exposure of healthy humans and compared it to filtered air at a separate exposure occasion. Eicosanoids and other oxylipins, as well as endocannabinoids and related lipids, were quantified in plasma from 14 healthy volunteers at baseline and at three subsequent time points (2, 6, and 24 h) after 1 h exposure sessions. Protocols based on liquid chromatography (LC) coupled to tandem mass spectrometry (MS/MS) methods were developed to detect temporal changes in circulating levels after biodiesel exhaust exposure. The exhaust was generated by a diesel engine fed with an undiluted rapeseed methyl ester fuel. Among the 51 analyzed lipid metabolites, PGF 2α , 9,10-DiHOME, 9-HODE, 5-HETE, 11-HETE, 12-HETE, and DEA displayed significant responsiveness to the biodiesel exhaust exposure as opposed to filtered air. Of these, 9-HODE and 5-HETE at 24 h survived the 10% false discovery rate cutoff (p emphasis on metabolites with inflammation related properties and implications on cardiovascular health and disease. These observations aid future investigations on air pollution effects, especially with regard to cardiovascular outcomes. Copyright © 2018 Elsevier B.V. All rights reserved.

  19. Real time plasma control experiments using the JET auxiliary plasma heating systems as the actuator

    International Nuclear Information System (INIS)

    Zornig, N.H.

    1999-01-01

    The role of the Real Time Power Control system (RTPC) in the Joint European Torus (JET) is described in depth. The modes of operation are discussed in detail and a number of successful experiments are described. These experiments prove that RTPC can be used for a wide range of experiments, including: (1) Feedback control of plasma parameters in real time using Ion Cyclotron Resonance Heating (ICRH) or Neutral Beam Heating (NBH) as the actuator in various JET operating regimes. It is demonstrated that in a multi-parameter space it is not sufficient to control one global plasma parameter in order to avoid performance limiting events. (2) Restricting neutron production and subsequent machine activation resulting from high performance pulses. (3) The simulation of α-particle heating effects in a DT-plasma in a D-only plasma. The heating properties of α-particles are simulated using ICRH-power, which is adjusted in real time. The simulation of α-particle heating in JET allows the effects of a change in isotopic mass to be separated from α-particle heating. However, the change in isotopic mass of the plasma ions appears to affect not only the global energy confinement time (τ E ) but also other parameters such as the electron temperature at the plasma edge. This also affects τ E , making it difficult to make a conclusive statement about any isotopic effect. (4) For future JET experiments a scheme has been designed which simulates the behaviour of a fusion reactor experimentally. The design parameters of the International Thermonuclear Experimental Reactor (ITER) are used. In the proposed scheme the most relevant dimensionless plasma parameters are similar in JET and ITER. It is also shown how the amount of heating may be simulated in real time by RTPC using the electron temperature and density as input parameters. The results of two demonstration experiments are presented. (author)

  20. Laser system for measuring small changes in plasma tracer concentrations.

    Science.gov (United States)

    Klaesner, J W; Pou, N A; Parker, R E; Galloway, R L; Roselli, R J

    1996-01-01

    The authors developed a laser-diode system that can be used for on-line optical concentration measurements in physiologic systems. Previous optical systems applied to whole blood have been hampered by artifacts introduced by red blood cells (RBCs). The system introduced here uses a commercially available filter cartridge to separate RBCs from plasma before plasma concentration measurements are made at a single wavelength. The filtering characteristics of the Cellco filter cartridge (#4007-10, German-town, MD) were adequate for use in the on-line measurement system. The response time of the filter cartridge was less than 40 seconds, and the sieving characteristics of the filter for macromolecules were excellent, with filtrate-to-plasma albumin ratios of 0.98 +/- 0.11 for studies in sheep and 0.94 +/- 0.15 for studies in dogs. The 635-nm laser diode system developed was shown to be more sensitive than the spectrophotometer used in previous studies (Klaesner et al., Annals of Biomedical Engineering, 1994; 22, 660-73). The new system was used to measure the product of filtration coefficient (Kfc) and reflection coefficient for albumin (delta f) in an isolated canine lung preparation. The delta fKfc values [mL/(cmH2O.min.100 g dry lung weight)] measured with the laser diode system (0.33 +/- 0.22) compared favorably with the delta fKfc obtained using a spectrophotometer (0.27 +/- 0.20) and with the Kfc obtained using the blood-corrected gravimetric method (0.32 +/- 0.23). Thus, this new optical system was shown to accurately measure plasma concentration changes in whole blood for physiologic levels of Kfc. The same system can be used with different optical tracers and different source wavelengths to make optical plasma concentration measurements for other physiologic applications.

  1. Overview of DOE Radiation Exposure Information Reporting System (REIRS)

    International Nuclear Information System (INIS)

    Fix, J.J.; Briscoe, G.J.; Selby, J.M.; Vallario, E.J.

    1981-05-01

    The purpose of the study is to determine the adequacy of the present system, identify any necessary short-term improvements and propose feasible alternatives for an improved system. The study includes topical reports as follows: current Personnel Dosimetry Practices at DOE Facilities; overview of DOE Radiation Exposure Information Reporting System (REIRS); and alternatives to Provide Upgraded Occupational Exposure Record System. This study constitutes the second report and was a joint effort between Battelle Northwest and EG and G, Idaho Falls. EG and G has been responsible for the respository since the fall of 1978

  2. Structure of the automatic system for plasma equilibrium position control

    International Nuclear Information System (INIS)

    Gubarev, V.F.; Krivonos, Yu.G.; Samojlenko, Yu.I.; Snegur, A.A.

    1978-01-01

    Considered are the principles of construction of the automatic system for plasma filament equilibrium position control inside the discharge chamber for the installation of a tokamak type. The combined current control system in control winding is suggested. The most powerful subsystem creates current in the control winding according to the program calculated beforehand. This system provides plasma rough equilibrium along the ''big radius''. The subsystem performing the current change in small limits according to the principle of feed-back coupling is provided simultaneously. The stabilization of plasma position is achieved in the discharge chamber. The advantage of construction of such system is in decreasing of the automatic requlator power without lowering the requirements to the accuracy of equilibrium preservation. The subsystem of automatic control of plasma position over the vertical is put into the system. Such an approach to the construction of the automatic control system proves to be correct; it is based on the experience of application of similar devices for some existing thermonuclear plants

  3. Effect of ultraviolet exposure on mitochondrial respiratory system

    Energy Technology Data Exchange (ETDEWEB)

    Noda, K [Kurume Univ., Fukuoka (Japan). School of Medicine

    1975-09-01

    To find the photodynamic effect of ultraviolet light on the mitochondrial respiratory chain, mitochondria were obtained from rat livers, and the suspension was exposed to an extensive ultraviolet light. The oxygen consumption was measured polarographically with a Clark oxygen electrode. The effect of ultraviolet exposure on the five states of respiratory control (Chance and Williams), the P/O ratio, and the respiratory control index in mitochondria was discussed. The ultraviolet light with a dose of 9.6 x 10/sup 6/ erg/cm/sup 2/ caused the oxidative phosphorylation in mitochondria to uncouple. The 2nd phosphorylation site of the respiratory chain was susceptible to ultraviolet exposure. The stimulation of latent ATPase activity in mitochondria following exposure was observed by increasing exposure of ultraviolet light. However, DNP-stimulated ATPase was found to be stable in activity. The uncoupling of the respiratory chain by ultraviolet exposure was not detected if the mitochondrial suspension was preincubated with bovine serum albumin before exposure. The changes in light absorption of the mitochondrial suspension were followed at 520 nm after exposure. A close correlation was found between the ultraviolet exposure and swelling in mitochondria. But, the reversing contraction was observed by adding ATP to the swelled mitochondria. The peroxide compound was formed in mitochondria irradiated with ultraviolet light. The amount of compounds formed was dependent on the radiant energy of ultraviolet light. The possible mechanisms involved in the photodynamic effect of ultraviolet light to the mitochondrial respiration system were discussed.

  4. Recent progress in the modelling of thermal plasma systems

    International Nuclear Information System (INIS)

    Xi Chen

    2002-01-01

    Plasma flow and heat transfer in thermal plasma systems are often of three-dimensional (3-D) features and cannot be well studied by use of a two-dimensional modelling approach. 3-D modelling studies are recently performed in our group. It is found that appreciable 3-D effects exist within non-transferred DC arc plasma torches even for the case with axisymmetrical external conditions. The key for the successful 3-D modelling of the non-transferred arc plasma torch is that the anode-nozzle wall is included in the computational domain. The predicted results are favorably compared with experimental observation. 3-D modelling of the plasma jets with lateral injection of particulate matter and its carrier gas also reveals distinct 3-D effects with the injection velocity and the distance between the carrier-gas injection-tube tip and the jet edge as critical parameters. The 3-D effects appreciably influence the trajectories and heating histories of particles injected into the plasma jet. (author)

  5. Drone based measurement system for radiofrequency exposure assessment.

    Science.gov (United States)

    Joseph, Wout; Aerts, Sam; Vandenbossche, Matthias; Thielens, Arno; Martens, Luc

    2016-03-10

    For the first time, a method to assess radiofrequency (RF) electromagnetic field (EMF) exposure of the general public in real environments with a true free-space antenna system is presented. Using lightweight electronics and multiple antennas placed on a drone, it is possible to perform exposure measurements. This technique will enable researchers to measure three-dimensional RF-EMF exposure patterns accurately in the future and at locations currently difficult to access. A measurement procedure and appropriate measurement settings have been developed. As an application, outdoor measurements are performed as a function of height up to 60 m for Global System for Mobile Communications (GSM) 900 MHz base station exposure. Bioelectromagnetics. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  6. New DIII-D tokamak plasma control system

    International Nuclear Information System (INIS)

    Campbell, G.L.; Ferron, J.R.; McKee, E.; Nerem, A.; Smith, T.; Greenfield, C.M.; Pinsker, R.I.; Lazarus, E.A.

    1992-09-01

    A state-of-the-art plasma control system has been constructed for use on the DIII-D tokamak to provide high speed real time data acquisition and feedback control of DIII-D plasma parameters. This new system has increased the precision to which discharge shape and position parameters can be maintained and has provided the means to rapidly change from one plasma configuration to another. The capability to control the plasma total energy and the ICRF antenna loading resistance has been demonstrated. The speed and accuracy of this digital system will allow control of the current drive and heating systems in order to regulate the current and pressure profiles and diverter power deposition in the DIII-D machine. Use of this system will allow the machine and power supplies to be better protected from undesirable operating regimes. The advanced control system is also suitable for control algorithm development for future machines in these areas and others such as disruption avoidance. The DIII-D tokamak facility is operated for the US Department of Energy by General Atomics Company (GA) in San Diego, California. The DIII-D experimental program will increase emphasis on rf heating and current drive in the near future and is installing a cryopumped divertor ring during the fall of 1992. To improve the flexibility of this machine for these experiments, the new shape control system was implemented. The new advanced plasma control system has enhanced the capabilities of the DIII-D machine and provides a data acquisition and control platform that promises to be useful far beyond its original charter

  7. Implementation strategy for the ITER plasma control system

    International Nuclear Information System (INIS)

    Winter, A.; Ambrosino, G.; Bauvir, B.; De Tommasi, G.; Humphreys, D.A.; Mattei, M.; Neto, A.; Raupp, G.; Snipes, J.A.; Stephen, A.V.; Treutterer, W.; Walker, M.L.; Zabeo, L.

    2015-01-01

    This paper gives an overview of the scope and context of the CODAC high-level real-time applications (Supervision and Plasma Control) and presents the strategy and current state of design of the tools to support the implementation. A real-time framework, which is currently under development with strong support of the worldwide fusion community will not only support the implementation of plasma control strategies with the extensive exception handling and forecasting functionality foreseen for ITER, but also integrated commissioning, orchestration and supervision as well as the real-time needs of ITER plant system developers. A second cornerstone in the implementation strategy is the development of a powerful simulation environment (Plasma Control System Simulation Platform – PCSSP) to design and verify control strategies, event handling and orchestration and automation. The development of PCSSP is currently under contract and this paper will also give an overview of its current state of development.

  8. Implementation strategy for the ITER plasma control system

    Energy Technology Data Exchange (ETDEWEB)

    Winter, A., E-mail: axel.winter@iter.org [ITER Organization, Route de Vinon-sur-Verdon, CS 90 046, 13067 St Paul Lez Durance Cedex (France); Ambrosino, G. [CREATE/Università di Napoli Federico II, Dip. Ingegneria Elettrica e delle Tecnologie dell’Informazione (Italy); Bauvir, B. [ITER Organization, Route de Vinon-sur-Verdon, CS 90 046, 13067 St Paul Lez Durance Cedex (France); De Tommasi, G. [CREATE/Università di Napoli Federico II, Dip. Ingegneria Elettrica e delle Tecnologie dell’Informazione (Italy); Humphreys, D.A. [General Atomics, San Diego, CA (United States); Mattei, M. [CREATE/Seconda Università di Napoli, Dip. Ingegneria Industriale e dell’Informazione (Italy); Neto, A. [Fusion for Energy, Barcelona (Spain); Raupp, G. [Max Planck Institute for Plasma Physics, EURATOM Association, Garching (Germany); Snipes, J.A. [ITER Organization, Route de Vinon-sur-Verdon, CS 90 046, 13067 St Paul Lez Durance Cedex (France); Stephen, A.V. [Culham Centre for Fusion Energy, Culham Science Centre, Abingdon (United Kingdom); Treutterer, W. [Max Planck Institute for Plasma Physics, EURATOM Association, Garching (Germany); Walker, M.L. [General Atomics, San Diego, CA (United States); Zabeo, L. [ITER Organization, Route de Vinon-sur-Verdon, CS 90 046, 13067 St Paul Lez Durance Cedex (France)

    2015-10-15

    This paper gives an overview of the scope and context of the CODAC high-level real-time applications (Supervision and Plasma Control) and presents the strategy and current state of design of the tools to support the implementation. A real-time framework, which is currently under development with strong support of the worldwide fusion community will not only support the implementation of plasma control strategies with the extensive exception handling and forecasting functionality foreseen for ITER, but also integrated commissioning, orchestration and supervision as well as the real-time needs of ITER plant system developers. A second cornerstone in the implementation strategy is the development of a powerful simulation environment (Plasma Control System Simulation Platform – PCSSP) to design and verify control strategies, event handling and orchestration and automation. The development of PCSSP is currently under contract and this paper will also give an overview of its current state of development.

  9. Development of the 'JFT-2' tokamak plasma position control system

    International Nuclear Information System (INIS)

    Fujisawa, Noboru; Matsuzaki, Yoshimi; Suzuki, Norio; Murai, Katsuji; Suzuki, Satoshi.

    1980-01-01

    Digital control technique was applied to control the plasma position in the JFT-2 tokamak experiment device. The detail of the JFT-2 is described elsewhere. The plasma position control system consists of a Hitachi control computer, HIDIC 80, and a Hitachi micro-computer, HIDIC 08E. The plasma position is detected by the position control computer, and compared with a preset value. Then, a reference signal is supplied to the micro-computer controlling power source, and the phase control of the thyristor controlling power source is performed. Since the behavior of plasma is very fast, the fast control is required. The control of the thyristor controlling power source is made by direct digital control (DDC). The main component of the hardware of the present system is the micro-computer HIDIC 08E. The software is the direct task system without the operating system (OS). The results of experiments showed that the feedback control of the system worked well. (Kato, T.)

  10. Interprocess communication within the DIII-D plasma control system

    International Nuclear Information System (INIS)

    Piglowski, D.A.; Penaflor, B.G.; Ferron, J.R.

    1999-06-01

    The DIII-D tokamak fusion research experiment's real-time digital plasma control system (PCS) is a complex and ever evolving system. During a plasma experiment, it is tasked with some of the most crucial functions at DIII-D. Key responsibilities of the PCS involve sub-system control, data acquisition/storage, and user interface. To accomplish these functions, the PCS is broken down into individual components (both software and hardware), each capable of handling a specific duty set. Constant interaction between these components is necessary prior, during and after a standard plasma cycle. Complicating the matter even more is that some components, mostly those which deal with user interaction, may exist remotely, that is to say they are not part of the immediate hardware which makes up the bulk of the PCS. The four main objectives of this paper are to (1) present a brief outline of the PCS hardware/software and how they relate to each other; (2) present a brief overview of a standard DIII-D plasma cycle (a shot); (3) using three sets of PCS sub-systems, describe in more detail the communication processes; and (4) evaluate the benefits and drawbacks of said systems

  11. ALPS - advanced limiter-divertor plasma-facing systems

    International Nuclear Information System (INIS)

    Allain, J. P.; Bastasz, R.; Brooks, J. N.; Evans, T.; Hassanein, A.; Luckhardt, S.; Maingi, R.; Mattas, R. F.; McCarthy, K.; Mioduszewski, P.; Mogahed, E.; Moir, R.; Molokov, S.; Morely, N.; Nygren, R.; Reed, C.; Rognlien, T.; Ruzic, D.; Sviatoslavsky, I.; Sze, D.; Tillack, M.; Ulrickson, M.; Wade, P. M.; Wong, C.; Wooley, R.

    1999-01-01

    The Advanced Limiter-divertor Plasma-facing Systems (ALPS) program was initiated in order to evaluate the potential for improved performance and lifetime for plasma-facing systems. The main goal of the program is to demonstrate the advantages of advanced limiter/divertor systems over conventional systems in terms of power density capability, component lifetime, and power conversion efficiency, while providing for safe operation and minimizing impurity concerns for the plasma. Most of the work to date has been applied to free surface liquids. A multi-disciplinary team from several institutions has been organized to address the key issues associated with these systems. The main performance goals for advanced limiters and diverters are a peak heat flux of >50 MW/m 2 ,elimination of a lifetime limit for erosion, and the ability to extract useful heat at high power conversion efficiency (approximately40%). The evaluation of various options is being conducted through a combination of laboratory experiments, modeling of key processes, and conceptual design studies. The current emphasis for the work is on the effects of free surface liquids on plasma edge performance

  12. Design of exposure systems for ELF electric field bioeffects research

    International Nuclear Information System (INIS)

    Kaune, W.T.; Decker, J.R.; Phillips, R.D.; Gillis, M.F.

    1978-01-01

    Two systems for exposure and sham-exposure of large numbers of rats and mice to uniform, vertical, 60-Hz electric fields have been constructed. The rat system contains four racks of four rectangular 1.0m x 2.2m exposure-electrodes that are stacked vertically with a separation between adjacent electrodes of 0.41 m. Any two of the four exposure racks may be energized to a maximum field strength of 150 kV/m. Each exposure electrode is equipped with 24 Lexan cages, each of which holds a single rat. The cage floor is a stainless steel screen that serves as one electrode. The system for watering animals is contained entirely within the electrode and does not protrude above the cage's floor, thereby preventing distortion of the exposure field and electrical shock or discharge as the animal drinks. The total capacity of the system is 288 rats. A similar system of two racks of five electrodes each is used to expose as many as 450 mice to fields at a maximum strength of 150 kV/m while sham exposing an equal number. Measurements of the electric field reveal an overall uniformity within 4% over the area to be occupied by experimental animals. The field inside a Lexan cage is reduced by about 3%. No corona-discharge has been detected. Measurements of ozone concentration in the rat and mouse exposure systems show no difference from background levels. Harmonic distortion has been eliminated by damping and filtering the high-voltage supply. Animals housed in close proximity are partially shielded from the electric field; the total body current in a rat model is reduced by 35 ± 5% when rats are placed in adjacent cages. (author)

  13. In Vitro Exposure Systems and Dosimetry Assessment Tools ...

    Science.gov (United States)

    In 2009, the passing of The Family Smoking Prevention and Tobacco Control Act facilitated the establishment of the FDA Center for Tobacco Products (CTP) and gave it regulatory authority over the marketing, manufacture and distribution of tobacco products, including those termed “modified risk”. On 4-6 April 2016, the Institute for In Vitro Sciences, Inc. (IIVS) convened a workshop conference titled “In Vitro Exposure Systems and Dosimetry Assessment Tools for Inhaled Tobacco Products” to bring together stakeholders representing regulatory agencies, academia, and industry to address the research priorities articulated by the FDA CTP. Specific topics were covered to assess the status of current in vitro smoke and aerosol/vapor exposure systems, as well as the various approaches and challenges to quantifying the complex exposures, in in vitro pulmonary models developed for evaluating adverse pulmonary events resulting from tobacco product exposures. The four core topics covered were, 1) Tobacco Smoke And E-Cigarette Aerosols, 2) Air-Liquid Interface-In Vitro Exposure Systems, 3) Dosimetry Approaches For Particles And Vapors; In Vitro Dosimetry Determinations and 4) Exposure Microenvironment/Physiology Of Cells. The two and a half day workshop included presentations from 20 expert speakers, poster sessions, networking discussions, and breakout sessions which identified key findings and provided recommendations to advance these technologies. Here, we will re

  14. Modulation of Erythrocyte Plasma Membrane Redox System Activity by Curcumin

    Directory of Open Access Journals (Sweden)

    Prabhakar Singh

    2016-01-01

    Full Text Available Plasma membrane redox system (PMRS is an electron transport chain system ubiquitously present throughout all cell types. It transfers electron from intracellular substrates to extracellular acceptors for regulation of redox status. Curcumin, isolated from Curcuma longa, has modulatory effects on cellular physiology due to its membrane interaction ability and antioxidant potential. The present study investigates the effect of curcumin on PMRS activity of erythrocytes isolated from Wistar rats in vitro and in vivo and validated through an in silico docking simulation study using Molegro Virtual Docker (MVD. Effects of curcumin were also evaluated on level of glutathione (GSH and the oxidant potential of plasma measured in terms of plasma ferric equivalent oxidative potentials (PFEOP. Results show that curcumin significantly (p<0.01 downregulated the PMRS activity in a dose-dependent manner. Molecular docking results suggest that curcumin interacts with amino acids at the active site cavity of cytochrome b5 reductase, a key constituent of PMRS. Curcumin also increased the GSH level in erythrocytes and plasma while simultaneously decreasing the oxidant potential (PFEOP of plasma. Altered PMRS activity and redox status are associated with the pathophysiology of several health complications including aging and diabetes; hence, the above finding may explain part of the role of curcumin in health beneficial effects.

  15. Occupational exposures at a polyvinyl chloride production facility are associated with significant changes to the plasma metabolome

    International Nuclear Information System (INIS)

    Guardiola, John J.; Beier, Juliane I.; Falkner, K. Cameron; Wheeler, Benjamin; McClain, Craig James; Cave, Matt

    2016-01-01

    Background: Occupational vinyl chloride (VC) exposures have been associated with toxicant-associated steatohepatitis and liver cancer. Metabolomics has been used to clarify mode of action in drug-induced liver injury but has not been performed following VC exposures. Methods: Plasma samples from 17 highly exposed VC workers without liver cancer and 27 unexposed healthy volunteers were obtained for metabolite extraction and GC/MS and LC/MS 2 analysis. Following ion identification/quantification, Ingenuity pathway analysis was performed. Results: 613 unique named metabolites were identified. Of these, 189 metabolites were increased in the VC exposure group while 94 metabolites were decreased. Random Forest analysis indicated that the metabolite signature could separate the groups with 94% accuracy. VC exposures were associated with increased long chain (including arachidonic acid) and essential (including linoleic acid) fatty acids. Occupational exposure increased lipid peroxidation products including monohydroxy fatty acids (including 13-HODE); fatty acid dicarboxylates; and oxidized arachidonic acid products (including 5,9, and 15-HETE). Carnitine and carnitine esters were decreased, suggesting peroxisomal/mitochondrial dysfunction and alternate modes of lipid oxidation. Differentially regulated metabolites were shown to interact with extracellular-signal-regulated kinase 1/2 (ERK1/2), Akt, AMP-activated protein kinase (AMPK), and the N-Methyl-D-aspartate (NMDA) receptor. The top canonical pathways affected by occupational exposure included tRNA charging, nucleotide degradation, amino acid synthesis/degradation and urea cycle. Methionine and homocysteine was increased with decreased cysteine, suggesting altered 1-carbon metabolism. Conclusions: Occupational exposure generated a distinct plasma metabolome with markedly altered lipid and amino acid metabolites. ERK1/2, Akt, AMPK, and NMDA were identified as protein targets for vinyl chloride toxicity. - Highlights:

  16. Occupational exposures at a polyvinyl chloride production facility are associated with significant changes to the plasma metabolome

    Energy Technology Data Exchange (ETDEWEB)

    Guardiola, John J. [University of Louisville Department of Medicine, Louisville, KY 40206 (United States); Beier, Juliane I. [Department of Pharmacology and Toxicology, Louisville, KY 40206 (United States); Falkner, K. Cameron; Wheeler, Benjamin [Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, Louisville, KY 40206 (United States); McClain, Craig James [Department of Pharmacology and Toxicology, Louisville, KY 40206 (United States); Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, Louisville, KY 40206 (United States); The Robley Rex Veterans Affairs Medical Center, Louisville, KY, 40206 (United States); The Kentucky One Health Jewish Hospital Liver Transplant Program, Louisville, KY 40202 (United States); Cave, Matt, E-mail: matt.cave@louisville.edu [Department of Pharmacology and Toxicology, Louisville, KY 40206 (United States); Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, Louisville, KY 40206 (United States); The Robley Rex Veterans Affairs Medical Center, Louisville, KY, 40206 (United States); The Kentucky One Health Jewish Hospital Liver Transplant Program, Louisville, KY 40202 (United States); Department of Biochemistry and Molecular Biology, Louisville, KY, 40202 (United States)

    2016-12-15

    Background: Occupational vinyl chloride (VC) exposures have been associated with toxicant-associated steatohepatitis and liver cancer. Metabolomics has been used to clarify mode of action in drug-induced liver injury but has not been performed following VC exposures. Methods: Plasma samples from 17 highly exposed VC workers without liver cancer and 27 unexposed healthy volunteers were obtained for metabolite extraction and GC/MS and LC/MS{sup 2} analysis. Following ion identification/quantification, Ingenuity pathway analysis was performed. Results: 613 unique named metabolites were identified. Of these, 189 metabolites were increased in the VC exposure group while 94 metabolites were decreased. Random Forest analysis indicated that the metabolite signature could separate the groups with 94% accuracy. VC exposures were associated with increased long chain (including arachidonic acid) and essential (including linoleic acid) fatty acids. Occupational exposure increased lipid peroxidation products including monohydroxy fatty acids (including 13-HODE); fatty acid dicarboxylates; and oxidized arachidonic acid products (including 5,9, and 15-HETE). Carnitine and carnitine esters were decreased, suggesting peroxisomal/mitochondrial dysfunction and alternate modes of lipid oxidation. Differentially regulated metabolites were shown to interact with extracellular-signal-regulated kinase 1/2 (ERK1/2), Akt, AMP-activated protein kinase (AMPK), and the N-Methyl-D-aspartate (NMDA) receptor. The top canonical pathways affected by occupational exposure included tRNA charging, nucleotide degradation, amino acid synthesis/degradation and urea cycle. Methionine and homocysteine was increased with decreased cysteine, suggesting altered 1-carbon metabolism. Conclusions: Occupational exposure generated a distinct plasma metabolome with markedly altered lipid and amino acid metabolites. ERK1/2, Akt, AMPK, and NMDA were identified as protein targets for vinyl chloride toxicity

  17. Wave Propagation in an Ion Beam-Plasma System

    DEFF Research Database (Denmark)

    Jensen, T. D.; Michelsen, Poul; Juul Rasmussen, Jens

    1979-01-01

    The spatial evolution of a velocity- or density-modulated ion beam is calculated for stable and unstable ion beam plasma systems, using the linearized Vlasov-Poisson equations. The propagation properties are found to be strongly dependent on the form of modulation. In the case of velocity...

  18. Large vacuum system for experiences in magnetic confined plasmas

    International Nuclear Information System (INIS)

    Honda, R.Y.; Kayama, M.E.; Boeckelmann, H.K.; Aihara, S.

    1984-01-01

    It is presented the operation method of a theta-pinch system capable of generating and confine plasmas with high densities and temperatures. Some characteristics of Tupa theta-pinch, which is operating at UNICAMP, emphasizing the cleaning mode of the vacuum chamber, are also presented. (M.C.K.) [pt

  19. Infrared laser scattering system for the plasma diagnostics

    International Nuclear Information System (INIS)

    Hiraki, Naoji; Kawasaki, Shoji; Muraoka, Katsunori

    1975-01-01

    As the results of the parametric studies of the double discharge TEA CO 2 laser, the required properties on the laser system for the scattering diagnostics of plasmas are shown to be realized with our CO 2 laser. The direction of the future improvements of the laser performance is also discussed. (auth.)

  20. Introduction of fusion driven subcritical system plasma design

    International Nuclear Information System (INIS)

    Bin Wu

    2003-01-01

    Fusion driven subcritical nuclear system (FDS) is a multifunctional hybrid reactor, which could breed nuclear fuel, transmute long-lived wastes, producing tritium and so on. This paper presents an introduction of FDS plasma design. Several different advance equilibrium configurations have been proposed and a 1.5-D discharge simulation of FDS was also present

  1. Experimental studies of plasma confinement in toroidal systems

    International Nuclear Information System (INIS)

    Bodin, H.A.B.; Keen, B.E.

    1977-01-01

    In this article the closed-line magnetic field approach to the plasma isolation and confinement problem in toroidal systems is reviewed. The theoretical aspects of closed-line magnetic field systems, indicating that topologically such systems are toroidal, are surveyed under the headings; topology of closed-line systems, equilibrium in different configurations and classification of toroidal devices, MHD stability, non-ideal effects in MHD stability, microscopic stability, and plasma energy loss. A section covering the experimental results of plasma confinement in toroidal geometry considers Stellerators, Tokamaks, toroidal pinch -the reversed-field pinch, screw pinches and high-β Tokamaks, Levitrons and multipoles (internal-ring devices), and miscellaneous toroidal containment devices. Recent achievements and the present position are discussed with reference to the status of Tokamak research, low-β stellerator research and high-β research. It is concluded from the continuing progress made in this research that the criteria for the magnetic containment of plasmas can be met. Further, it is concluded that the construction of a successful and economic fusion reactor is within the scope of advancing science and technology. 250 references. (U.K.)

  2. Experimental studies of plasma confinement in toroidal systems

    Energy Technology Data Exchange (ETDEWEB)

    Bodin, H A.B.; Keen, B E [UKAEA, Abingdon. Culham Lab.

    1977-12-01

    In this article the closed-line magnetic field approach to the plasma isolation and confinement problem in toroidal systems is reviewed. The theoretical aspects of closed-line magnetic field systems, indicating that topologically such systems are toroidal, are surveyed under the headings; topology of closed-line systems, equilibrium in different configurations and classification of toroidal devices, MHD stability, non-ideal effects in MHD stability, microscopic stability, and plasma energy loss. A section covering the experimental results of plasma confinement in toroidal geometry considers Stellerators, Tokamaks, toroidal pinch -the reversed-field pinch, screw pinches and high-..beta.. Tokamaks, Levitrons and multipoles (internal-ring devices), and miscellaneous toroidal containment devices. Recent achievements and the present position are discussed with reference to the status of Tokamak research, low-..beta.. stellerator research and high-..beta.. research. It is concluded from the continuing progress made in this research that the criteria for the magnetic containment of plasmas can be met. Further, it is concluded that the construction of a successful and economic fusion reactor is within the scope of advancing science and technology. 250 references.

  3. Exposures of EU W-CFC combined targets with QSPA Kh-50 plasma streams simulating ITER ELM

    International Nuclear Information System (INIS)

    Makhlaj, V.A.; Garkusha, I.E.; Tereshin, V.I.; Bandura, A.N.; Chebotarev, V.V.; Staltsov, V.V.; Linke, J.; Pintsuk, G.

    2009-01-01

    Repeated load tests of special combined W-CFC samples were performed with QSPA plasma streams either resulting in strong melting of W surface layer or below the melting, but above the cracking threshold. Experiments show that in result of target exposures with heat load of 0.4 MJ/m 2 (no melting) only cracks formation was found on both tungsten and CFC surfaces. It is obtained that enhanced evaporation of CFC results in additional shielding of tungsten surface by C cloud and protects W surface from evaporation even for essentially increased energy density in impacting plasma. Exposures of combined target with heat loads of 0.82 MJ/m 2 resulted in strong melting of tungsten. Meshes of macro-cracks and micro-cracks as well as ripple structures are appeared on the resolidified surface

  4. Sticky situations: cyanoacrylate exposures reported to a poison control system.

    Science.gov (United States)

    Carstairs, Shaun D; Koh, Cynthia; Qian, Lily; Qozi, Mariam; Seivard, Grant; Cantrell, F Lee

    2017-11-01

    Cyanoacrylate (Super Glue ® ) exposures are commonly reported to poison control centers, but little has been published in the medical literature regarding these exposures. We sought to characterize cyanoacrylate exposures reported to a poison control system. We performed a retrospective review of a poison system's database for all cases of single-substance human exposure to cyanoacrylate-containing products from 2005 to 2015. Data collected included age, gender, route of exposure, clinical effects, treatments recommended and medical outcome. There were a total of 893 patients, 505 (56.6%) of which were female. Patient ages ranged from 6 months to 88 years with a median of 11 years. The vast majority of exposures (n = 871, 97.5%) were unintentional, but a small number of exposures (n = 22, 2.5%) were due to intentional misuse (such as trying to stop a bleeding cut) or malicious intent (such as purposefully gluing a person's eyes shut as a prank). Routes of exposure included: ingestion, n = 337 (37.7%); ocular, n = 322 (36.1%); dermatologic, n = 285 (31.9%); inhalation, n = 16 (1.8%); nasal, n = 1 (0.1%); and otic, n = 1 (0.1%); some patients had multiple routes of exposure. Treatments recommended by the poison center included irrigation (n = 411), petroleum jelly (n = 143), mineral oil (n = 131), topical antibiotic ointment (n = 82), peanut butter (n = 6), acetone (n = 4) and WD-40 ® (n = 2). A total of 657 patients (73.6%) were managed on-site, while 236 (26.4%) were seen in a health care facility. Among all exposures, effects were classified as none (n = 287), minor (n = 529) and moderate (n = 77). No major effects or deaths were reported. In this case series, the majority of cases occurred in children and most exposures did not result in significant morbidity. Notably, there was wide variation in terms of recommended treatments; further study is needed to determine the optimal treatment

  5. Blood plasma clinical-chemical parameters as biomarker endpoints for organohalogen contaminant exposure in Norwegian raptor nestlings

    DEFF Research Database (Denmark)

    Sonne, Christian; Bustnes, Jan O.; Herzke, Dorte

    2012-01-01

    Raptors are exposed to biomagnifying and toxic organohalogenated compounds (OHCs) such as organochlorines, brominated flame retardants and perfluorinated compounds. To investigate how OHC exposure may affect biochemical pathways we collected blood plasma from Norwegian northern goshawk (n=56...... it is uncertain if such changes have any health effects. The OHC concentrations were below concentrations causing reproductive toxicity in adults of other raptor species but similar to those of concern for endocrine disruption of thyroid hormones in e.g., bald eagles....

  6. Radiation internal exposure measurements archiving system (REMAS)

    International Nuclear Information System (INIS)

    Bitar, A.; Maghrabi, M.

    2013-01-01

    This paper describes a personal-computer-based software, REMAS, which helps users to estimate intake activity and resulting internal doses for all radionuclides existing in (International Commission on Radiological Protection) ICRP 78 and other important elements. In addition to its use in internal dose calculations, it facilitates management of data of monitored persons who are occupationally exposed to unsealed radioactive substances. Furthermore, REMAS offers the possibility to generate different reports of results. The program is suitable for laboratories working in the field of assessment of occupational intake and also for users of radioactive material who are routinely monitored. REMAS, which is bilingual program (English and Arabic), was built with GUI environment and was developed using Microsoft FoxPro. It runs on Microsoft Windows XP operating systems. (authors)

  7. A computer system for occupational radiation exposure information

    International Nuclear Information System (INIS)

    Hunt, H.W.

    1984-01-01

    A computerized occupational radiation exposure information system has been developed to maintain records for contractors at the U.S. Department of Energy's (DOE) Hanford Site. The system also allows indexing and retrieval of three million documents from microfilm, thus significantly reducing storage needs and costs. The users are linked by display terminals to the data base permitting them instant access to dosemetry and other radiation exposure information. Personnel dosemeter and bioassay results, radiation training, respirator fittings, skin contaminations and other radiation occurrence records are included in the data base. The system yields immediate analysis of radiological exposures for operating management and health physics personnel, thereby releasing personnel to use their time more effectively

  8. New Radiofrequency Exposure System with Real Telecommunication Signals

    Directory of Open Access Journals (Sweden)

    Jakub Misek

    2018-01-01

    Full Text Available In recent years, there has been an increase in the number of studies on biological effects of Electromagnetic (EM fields emitted from Base Transceiver Stations (BTSs. The biological effects of generated and real telecommunication signals produced by different types of exposure systems are discussed. However, the proper exposure methods for such experiments are very limited. We successfully developed a simple and cost-effective exposure unit with real GSM/DCS/UMTS signal from BTS containing proper modulations or intermittence (continuous, interrupted. Signal processing and conditioning unit is based on a Radiofrequency (RF repeater. The downlink signal is filtered by integrated high selectivity passband filters and amplified to a required level. The main part of exposure unit is a Faraday cage with the specimen (exposure area measuring 150 x 250 mm with E-field percent deviation less than 18%. This exposure system can be helpful in experiments with living organisms in in vivo studies and in vitro studies with normal or pathological cells and other micro scale structures being exposed to RF EM fields from BTS.

  9. Associations between plasma concentrations of PCB 28 and possible indoor exposure sources in Danish school children and mothers

    DEFF Research Database (Denmark)

    Egsmose, Emilie Lund; Bräuner, Elvira Vaclavik; Frederiksen, Marie

    2016-01-01

    Background: Polychlorinated biphenyls (PCBs) are ubiquitously present in the environment and are suspected ofcarcinogenic, neurotoxic and immunotoxic effects. Significantly higher plasma concentrations of the congener PCB 28 occur in children compared to adults. Exposure in schools may contribute...... to this difference. Objective: To determine whether increased blood plasma concentrations of PCB 28 in Danish school children andmothers are associated with living in homes or attending schools constructed in the PCB period (1959–1977). Methods: PCB 28 was analyzed in plasma samples from 116 children aged 6–11 years...... and 143 mothers living inan urban and a rural area in Denmark and participating in the European pilot project DEMOCOPHES (Demonstrationof a study to COordinate and Perform Human Biomonitoring on a European Scale). In Denmark, PCBs wereused in construction in the period 1950–1977, and year of construction...

  10. Urinary nickel: measurement of exposure by inductively coupled plasma argon emission spectrometry.

    Science.gov (United States)

    Koizumi, Chisato; Usuda, Kan; Hayashi, Satsuki; Dote, Tomotaro; Kono, Koichi

    2004-09-01

    Nickel is a rare earth metal and is widely used in modern industry. Its overexposure in human beings can provoke significant effects including lung, cardiovascular and kidney diseases. As an index of occupational exposure, urine is widely used for the monitoring of nickel concentration because it is a minimally invasive method. Recent studies have used atomic absorption spectrometry to measure nickel concentration. In this study, we introduced novel inductively coupled plasma argon emission spectrometry (ICPAES) which enables us to measure multiple elements simultaneously with smaller volume and with lower detection limits compared to conventional atomic absorption emission spectrometry, and we established the new measuring method by determining the appropriate wavelengths for nickel concentration. Furthermore, using the established new measuring method, we investigated the correlation between a single oral administration of nickel and urine elimination in rats. As a result, different concentrations of nickel standard solutions were measured by ICPAES, and among five specific wavelengths of nickel, 221.647 and 231.604 nm were chosen because they had the highest inclines of both signal to background ratio and emission intensity in simple linear regression analysis. Next, by using healthy human urine samples that had not been exposed to nickel, 231.604 nm was determined to be the most appropriate wavelength because it did not present abnormal intensity due to obstacle wavelength. Male Wistar rats received an oral administration of nickel ranging from 0.025 to 250 mg/kg, which is equivalent to 0.0015 - 15% of LD50, and during the following 24 h, urine samples were collected and the nickel concentration was measured by ICPAES. With a single oral administration of nickel, there was an increase in urine nickel concentration in a dose-dependent manner and the appropriate equation was developed. Acute renal failure was not observed in this dosage of oral nickel

  11. Developmental exposure to fluoxetine modulates the serotonin system in hypothalamus.

    Directory of Open Access Journals (Sweden)

    Cecilia Berg

    Full Text Available The selective serotonin reuptake inhibitor (SSRI fluoxetine (FLU, Prozac® is commonly prescribed for depression in pregnant women. This results in SSRI exposure of the developing fetus. However, there are knowledge gaps regarding the impact of SSRI exposure during development. Given the role of serotonin in brain development and its cross-talk with sex hormone function, we investigated effects of developmental exposure to pharmacologically relevant concentrations of FLU (3 and 30 nM (measured on brain neurotransmitter levels, gonadal differentiation, aromatase activity in brain and gonads, and the thyroid system, using the Xenopus tropicalis model. Tadpoles were chronically exposed (8 weeks until metamorphosis. At metamorphosis brains were cryosectioned and levels of serotonin, dopamine, norepinephrine, and their metabolites 5-hydroxyindoleacetic acid, 3,4-dihydroxyphenylacetic acid, and homovanillic acid were measured in discrete regions (telencephalon, hypothalamus and the reticular formation of the cryosections using high-performance liquid chromatography. Exposure to 30 nM FLU increased the concentration of 5-hydroxyindoleacetic acid in hypothalamus compared with controls. FLU exposure did not affect survival, time to metamorphosis, thyroid histology, gonadal sex differentiation, or aromatase activity implying that the effect on the serotonergic neurotransmitter system in the hypothalamus region was specific. The FLU concentration that impacted the serotonin system is lower than the concentration measured in umbilical cord serum, suggesting that the serotonin system of the developing brain is highly sensitive to in utero exposure to FLU. To our knowledge this is the first study showing effects of developmental FLU exposure on brain neurochemistry. Given that SSRIs are present in the aquatic environment the current results warrant further investigation into the neurobehavioral effects of SSRIs in aquatic wildlife.

  12. Plasma dimethylglycine, nicotine exposure and risk of low bone mineral density and hip fracture: the Hordaland Health Study.

    Science.gov (United States)

    Øyen, J; Svingen, G F T; Gjesdal, C G; Tell, G S; Ueland, P M; Lysne, V; Apalset, E M; Meyer, K; Vollset, S E; Nygård, O K

    2015-05-01

    In the large community-based Hordaland Health Study, low plasma dimethylglycine was associated with low bone mineral density in both middle-aged and elderly subjects and to an increased risk of subsequent hip fracture among the elderly. These associations seemed to be particularly strong among subjects exposed to nicotine. Dimethylglycine (DMG) is a product of the choline oxidation pathway and formed from betaine during the folate-independent remethylation of homocysteine (Hcy) to methionine. Elevated plasma DMG levels are associated with atherosclerotic cardiovascular disease and inflammation, which in turn are related to osteoporosis. High plasma total Hcy and low plasma choline are associated with low bone mineral density (BMD) and hip fractures, but the role of plasma DMG in bone health is unknown. We studied the associations of plasma DMG with BMD among 5315 participants (46-49 and 71-74 years old) and with hip fracture among 3310 participants (71-74 years old) enrolled in the Hordaland Health Study. In age and sex-adjusted logistic regression models, subjects in the lowest versus highest DMG tertile were more likely to have low BMD (odds ratio [OR] 1.68, 95% confidence interval [CI] 1.43-1.99). The association was stronger in participants exposed compared to those unexposed to nicotine (OR 2.31, 95% CI 1.73-3.07 and OR 1.43, 95% CI 1.16-1.75, respectively, p interaction = 0.008). In the older cohort, Cox regression analyses adjusted for sex showed that low plasma DMG was associated with an increased risk of hip fracture (hazard ratio [HR] 1.70, 95% CI 1.28-2.26). A trend toward an even higher risk was found among women exposed to nicotine (HR 3.41, 95% CI 1.40-8.28). Low plasma DMG was associated with low BMD and increased risk of hip fractures. A potential effect modification by nicotine exposure merits particular attention.

  13. Remote network control plasma diagnostic system for Tokamak T-10

    International Nuclear Information System (INIS)

    Troynov, V I; Zimin, A M; Krupin, V A; Notkin, G E; Nurgaliev, M R

    2016-01-01

    The parameters of molecular plasma in closed magnetic trap is studied in this paper. Using the system of molecular diagnostics, which was designed by the authors on the «Tokamak T-10» facility, the radiation of hydrogen isotopes at the plasma edge is investigated. The scheme of optical radiation registration within visible spectrum is described. For visualization, identification and processing of registered molecular spectra a new software is developed using MatLab environment. The software also includes electronic atlas of electronic-vibrational-rotational transitions for molecules of protium and deuterium. To register radiation from limiter cross-section a network control system is designed using the means of the Internet/Intranet. Remote control system diagram and methods are given. The examples of web-interfaces for working out equipment control scenarios and viewing of results are provided. After test run in Intranet, the remote diagnostic system will be accessible through Internet. (paper)

  14. Neoclassical current and plasma rotation in helical systems

    International Nuclear Information System (INIS)

    Nakajima, N.; Okamoto, M.

    1991-01-01

    In order to clarify geometrical effects of the magnetic field on the neoclassical theory in general toroidal systems, the neoclassical parallel particle flow, heat flux, current and plasma rotation of a multispecies plasma are examined using the moment approach on the basis of the original papers under the assumptions of no fluctuations, no external sources and losses except for a fast ion beam and an external inductive electric field, steady state, and |u a | Ta where u a and v Ta are the macro and thermal velocity of species a, respectively. Hence, we might have a point of view of unifying understanding the neoclassical theory in general toroidal systems. Three collisionality regimes, i.e., the 1/ν (in non-axisymmetric toroidal systems) or banana (in axisymmetric toroidal systems), plateau, and Pfirsch-Schlueter collisionality regimes are examined separately. (author) 8 refs

  15. Precision microwave applicators and systems for plasma and materials processing

    International Nuclear Information System (INIS)

    Asmussen, J.; Garard, R.

    1988-01-01

    Modern applications of microwave energy have imposed new requirements upon microwave processing systems. Interest in energy efficiency, processing uniformity and control of process cycles has placed new design conditions upon microwave power oscillators, microwave systems and microwave applicator design. One approach of meeting new application requirements is the use of single-mode or controlled multimode applicators. The use of a single-mode applicator for plasma generation and materials processing will be presented. Descriptions of actual applicator designs for heating, curing, and processing of solid materials and the generations of high and low pressure discharges will be given. The impact of these applicators on the total microwave system including the microwave power source will be described. Specific examples of applicator and associated microwave systems will be detailed for the applications of (1) plasma thin film deposition and (2) the precision processing and diagnosis of materials. Methods of process control and diagnosis, control of process uniformity and process scale up are discussed

  16. Equilibrium and perturbations in plasma-vacuum systems

    International Nuclear Information System (INIS)

    Mercier, C.

    1974-01-01

    Thermonuclear plasmas must be maintained far from all material contact. In order to realize this condition, one uses in the vacuum surrounding the plasma, a metal wall supposed perfectly conducting and currents whose positions and intensities have to be suitably chosen. The problem of equilibrium consists of finding a toroidal solution of the system of equations JxB=grad P, div B=0, J=rot B, B,J, and P being respectively the magnetic field, current intensity and plasma pressure. The problem can be solved in symmetry of revolution using cylindrical coordinates. The arrangement and intensity of the currents found will not be exactly realized due to, for exemple, technical reasons. Consequently, the first problem of equilibrium is considered as a first approximation and the configuration which will be obtained under imposed real conditions is computed as perturbed equilibria [fr

  17. Studies of the influence of nonequilibrium plasma thermal exposure on the characteristics of the capillary-porous polymer material

    International Nuclear Information System (INIS)

    Makhotkina, L Yu; Khristoliubova, V I

    2017-01-01

    Capillary-porous materials, which include natural macromolecular tanning material, are exposed to a number of factors during the treatment by a nonequilibrium plasma. Plasma particles exchange the charge and energy with the atoms of the material during the interaction of the plasma with the surface. The results of treatment are desorption of atoms and molecules from the body surface, sputtering and evaporation of material’s particles, changes of the structure and phase state. In real terms during the modification of solids by nonequilibrium low-temperature plasma thermal effect influences the process. The energy supplied from the discharge during the process with low pressure, which is converted into heat, is significantly less than during the atmospheric pressure, but the thermal stability of high-molecular compounds used in the manufacture of materials and products of the tanning industry, is very limited and depends on the duration of the effect of temperature. Even short heating of hydrophilic polymers (proteins) (100-180 °C) causes a change in their properties. It decreases the collagen ability to absorb water vapor, to swell in water, acids, alkalis, and thus decreases their durability. Prolonged heating leads to a deterioration of the physical and mechanical properties. Higher heating temperatures it leads to the polymer degradation. The natural leather temperature during plasma exposure does not rise to a temperature of collagen degradation and does not result in changes of physical phase of the dermis. However, the thermal plasma exposure must be considered, since the high temperatures influence on physical and mechanical properties. (paper)

  18. Construction of pilot system for the Korea information system of occupational exposure

    International Nuclear Information System (INIS)

    Na, Seong Ho; Park, Moon Il; Im, Bok Soo; Lee, Seon Mi; Kim, Hyung Uk; Chae, Eun Yeong

    2003-01-01

    In this study, the construction of Korea Information System of Occupational Exposure (KISOE) system is designed with occupational exposure control system based on information evaluation technology and it makes the reliability of the personal exposure by use of personal dose verification. While the operation of national based radiation worker protection system, this system are settled the control system for radiation worker and ALARA. The purpose of construction and operation of pilot system of KISOE systematically is to derive the master plan of KISOE, stable development of this system, and serve the high quality radiation use internationally

  19. Construction of pilot system for the Korea information system of occupational exposure

    Energy Technology Data Exchange (ETDEWEB)

    Na, Seong Ho [Korea Institute of Nuclear Safety, Taejon (Korea, Republic of); Park, Moon Il; Im, Bok Soo; Lee, Seon Mi; Kim, Hyung Uk; Chae, Eun Yeong [ADDLAB Co., Ltd., Taejon (Korea, Republic of)

    2003-01-15

    In this study, the construction of Korea Information System of Occupational Exposure (KISOE) system is designed with occupational exposure control system based on information evaluation technology and it makes the reliability of the personal exposure by use of personal dose verification. While the operation of national based radiation worker protection system, this system are settled the control system for radiation worker and ALARA. The purpose of construction and operation of pilot system of KISOE systematically is to derive the master plan of KISOE, stable development of this system, and serve the high quality radiation use internationally.

  20. Prenatal Alcohol Exposure and the Developing Immune System

    OpenAIRE

    Gauthier, Theresa W.

    2015-01-01

    Evidence from research in humans and animals suggest that ingesting alcohol during pregnancy can disrupt the fetal immune system and result in an increased risk of infections and disease in newborns that may persist throughout life. Alcohol may have indirect effects on the immune system by increasing the risk of premature birth, which itself is a risk factor for immune-related problems. Animal studies suggest that alcohol exposure directly disrupts the developing immune system. A comprehensiv...

  1. Rilpivirine exposure in plasma and sanctuary site compartments after switching from nevirapine-containing combined antiretroviral therapy.

    Science.gov (United States)

    Mora-Peris, Borja; Watson, Victoria; Vera, Jaime H; Weston, Rosy; Waldman, Adam D; Kaye, Steve; Khoo, Saye; Mackie, Nicola E; Back, David; Winston, Alan

    2014-06-01

    Pharmacokinetic parameters following modifications to antiretroviral therapy and sanctuary site exposure are often unknown for recently licensed antiretrovirals. We assessed plasma, CSF and seminal plasma (SP) exposure of rilpivirine after switching from nevirapine. HIV-infected male subjects receiving tenofovir/emtricitabine/nevirapine (245/200/400 mg) once daily switched to tenofovir/emtricitabine/rilpivirine (245/200/25 mg) once daily for 60 days when CSF and semen samples were collected. Mean and individual plasma concentrations of nevirapine and rilpivirine were compared with the proposed plasma target concentration for nevirapine (3000 ng/mL) and the protein binding-adjusted EC90 for rilpivirine (12.1 ng/mL). Mean rilpivirine CSF and SP concentrations were calculated and individual values compared with the EC50 and EC90 for wild-type virus (0.27 and 0.66 ng/mL, respectively). Of 13 subjects completing study procedures including CSF examination, 8 provided seminal samples. By day 3, the mean plasma rilpivirine trough concentration was 29.7 ng/mL (95% CI: 23.8-37). No patient presented rilpivirine plasma concentrations under the proposed threshold. The mean rilpivirine concentration in CSF was 0.8 ng/mL (95% CI: 0.7-1.0), representing a CSF : plasma ratio of 1.4%, with concentrations above the EC90 in 85% (11/13) of patients. In SP, the mean rilpivirine concentration was 4.9 ng/mL (95% CI: 3.3-7.2), representing an SP : plasma ratio of 9.5%, with all concentrations above the EC90. Switching from nevirapine- to rilpivirine-containing antiretroviral therapy was safe and well tolerated, with plasma rilpivirine concentrations above the protein binding-adjusted EC90 in all subjects. Rilpivirine concentrations were always above the EC50 in the CSF and the EC90 in SP. © The Author 2014. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  2. Radiation Exposure Monitoring and Information Transmittal (REMIT) system

    International Nuclear Information System (INIS)

    Cale, R.; Clark, T.; Dixson, R.; Hagemeyer, D.

    1993-06-01

    The Radiation Exposure Monitoring and Information Transmittal (REMIT) system is designed to assist US Nuclear Regulatory Commission (NRC)licensees in meeting the reporting requirements of the revised 10 CFR 20 and in agreement with the guidance contained in R.G. 8.7, Rev. 1, ''Instructions for Recording and Reporting Occupational Exposure Data.'' REMIT is a personal computer (PC) based menu driven system that facilitates the manipulation of data base files to record and report radiation exposure information. REMIT is designed to be user-friendly and contains the full text of R. G. 8.7, Rev. 1, on-line as well as context-sensitive help throughout the program. The user can enter data directly from NRC Forms 4 or 5, REMIT allows the user to view the individual's exposure in relation to regulatory or administrative limits and alerts the user to exposures in excess of these limits. The system also provides for the calculation and summation of dose from intakes and the determination of the dose to the maximally exposed extremity for the monitoring year. REMIT can produce NRC Forms 4 and 5 in paper and electronic format and can import/export data from ASCII and data base files

  3. Responses of sympathetic nervous system to cold exposure in vibration syndrome subjects and age-matched healthy controls.

    Science.gov (United States)

    Nakamoto, M

    1990-01-01

    Plasma norepinephrine and epinephrine in vibration syndrome subjects and age-matched healthy controls were measured for the purpose of estimating the responsibility of the sympathetic nervous system to cold exposure. In preliminary experiment, it was confirmed that cold air exposure of the whole body was more suitable than one-hand immersion in cold water. In the main experiment, 195 subjects were examined. Sixty-five subjects had vibration syndrome with vibration-induced white finger (VWF + group) and 65 subjects had vibration syndrome without VWF (VWF- group) and 65 controls had no symptoms (control group). In the three groups, plasma norepinephrine levels increased during cold air exposure of whole body at 7 degrees +/- 1.5 degrees C. Blood pressure increased and skin temperature decreased during cold exposure. Percent increase of norepinephrine in the VWF+ group was the highest while that in VWF- group followed and that in the control group was the lowest. This whole-body response of the sympathetic nervous system to cold conditions reflected the VWF which are characteristic symptoms of vibration syndrome. Excluding the effects of shivering and a cold feeling under cold conditions, it was confirmed that the sympathetic nervous system in vibration syndrome is activated more than in the controls. These results suggest that vibration exposure to hand and arm affects the sympathetic nervous system.

  4. Architectural concept for the ITER Plasma Control System

    Energy Technology Data Exchange (ETDEWEB)

    Treutterer, W., E-mail: Wolfgang.Treutterer@ipp.mpg.de [Max-Planck Institute for Plasma Physics, EURATOM Association, Garching (Germany); Humphreys, D., E-mail: humphreys@fusion.gat.com [General Atomics, San Diego, CA (United States); Raupp, G., E-mail: Gerhard.Raupp@ipp.mpg.de [Max-Planck Institute for Plasma Physics, EURATOM Association, Garching (Germany); Schuster, E., E-mail: schuster@lehigh.edu [Lehigh University, Bethlehem, PA (United States); Snipes, J., E-mail: Joseph.Snipes@iter.org [ITER Organization, 13115 St. Paul-lez-Durance (France); De Tommasi, G., E-mail: detommas@unina.it [CREATE/Università di Napoli Federico II, Napoli (Italy); Walker, M., E-mail: walker@fusion.gat.com [General Atomics, San Diego, CA (United States); Winter, A., E-mail: Axel.Winter@iter.org [ITER Organization, 13115 St. Paul-lez-Durance (France)

    2014-05-15

    The plasma control system is a key instrument for successfully investigating the physics of burning plasma at ITER. It has the task to execute an experimental plan, known as pulse schedule, in the presence of complex relationships between plasma parameters like temperature, pressure, confinement and shape. The biggest challenge in the design of the control system is to find an adequate breakdown of this task in a hierarchy of feedback control functions. But it is also important to foresee structures that allow handling unplanned exceptional situations to protect the machine. Also the management of the limited number of actuator systems for multiple targets is an aspect with a strong impact on system architecture. Finally, the control system must be flexible and reconfigurable to cover the manifold facets of plasma behaviour and investigation goals. In order to prepare the development of a control system for ITER plasma operation, a conceptual design has been proposed by a group of worldwide experts and reviewed by an ITER panel in 2012. In this paper we describe the fundamental principles of the proposed control system architecture and how they were derived from a systematic collection and analysis of use cases and requirements. The experience and best practices from many fusion devices and research laboratories, augmented by the envisaged ITER specific tasks, build the foundation of this collection. In the next step control functions were distilled from this input. An analysis of the relationships between the functions allowed sequential and parallel structures, alternate branches and conflicting requirements to be identified. Finally, a concept of selectable control layers consisting of nested “compact controllers” was synthesised. Each control layer represents a cascaded scheme from high-level to elementary controllers and implements a control hierarchy. The compact controllers are used to resolve conflicts when several control functions would use the same

  5. Architectural concept for the ITER Plasma Control System

    International Nuclear Information System (INIS)

    Treutterer, W.; Humphreys, D.; Raupp, G.; Schuster, E.; Snipes, J.; De Tommasi, G.; Walker, M.; Winter, A.

    2014-01-01

    The plasma control system is a key instrument for successfully investigating the physics of burning plasma at ITER. It has the task to execute an experimental plan, known as pulse schedule, in the presence of complex relationships between plasma parameters like temperature, pressure, confinement and shape. The biggest challenge in the design of the control system is to find an adequate breakdown of this task in a hierarchy of feedback control functions. But it is also important to foresee structures that allow handling unplanned exceptional situations to protect the machine. Also the management of the limited number of actuator systems for multiple targets is an aspect with a strong impact on system architecture. Finally, the control system must be flexible and reconfigurable to cover the manifold facets of plasma behaviour and investigation goals. In order to prepare the development of a control system for ITER plasma operation, a conceptual design has been proposed by a group of worldwide experts and reviewed by an ITER panel in 2012. In this paper we describe the fundamental principles of the proposed control system architecture and how they were derived from a systematic collection and analysis of use cases and requirements. The experience and best practices from many fusion devices and research laboratories, augmented by the envisaged ITER specific tasks, build the foundation of this collection. In the next step control functions were distilled from this input. An analysis of the relationships between the functions allowed sequential and parallel structures, alternate branches and conflicting requirements to be identified. Finally, a concept of selectable control layers consisting of nested “compact controllers” was synthesised. Each control layer represents a cascaded scheme from high-level to elementary controllers and implements a control hierarchy. The compact controllers are used to resolve conflicts when several control functions would use the same

  6. Development and implementation of a new radiation exposure record system

    International Nuclear Information System (INIS)

    Lyon, M.; Berndt, V.L.; Trevino, G.W.; Oakley, B.M.

    1993-01-01

    The Hanford Radiological Records Program (HRRP) maintains all available radiation exposure records created since the 1940s for employees of and visitors to the Hanford Site. The program provides exposure status reports to the US Department of Energy Richland Operations Office (DOE-RL) and the Hanford contractors, annual exposure reports to individual employees and visitors, and exposure reports to terminated employees. Program staff respond to offsite requests for exposure data on former employees and supply data and reports for epidemiological and research projects as well as for annual reports required by DOE Orders. Historical files, documenting radiation protection and dosimetry policies, procedures, and practices, and radiological incidents, are also maintained under this program. The program is operated by Pacific Northwest Laboratory for DOE-RL. This paper describes how the record-keeping requirements supported by the HRRP's computerized radiation exposure database were analyzed so that the system could be redeveloped and implemented to (1) accommodate a change in mainframe computer units, and (2) to enhance its automated record-keeping, retrieval, and reporting capabilities in support of the HRRP

  7. Plasma D-dimer concentration in patients with systemic sclerosis

    Directory of Open Access Journals (Sweden)

    Montagnana Martina

    2006-01-01

    Full Text Available Abstract Background Systemic sclerosis (SSc is an autoimmune disorder of the connective tissue characterized by widespread vascular lesions and fibrosis. Little is known so far on the activation of the hemostatic and fibrinolytic systems in SSc, and most preliminary evidences are discordant. Methods To verify whether SSc patients might display a prothrombotic condition, plasma D-dimer was assessed in 28 consecutive SSc patients and in 33 control subjects, matched for age, sex and environmental habit. Results and discussion When compared to healthy controls, geometric mean and 95% confidence interval (IC95% of plasma D-dimer were significantly increased in SSc patients (362 ng/mL, IC 95%: 361–363 ng/mL vs 229 ng/mL, IC95%: 228–231 ng/mL, p = 0.005. After stratifying SSc patients according to disease subset, no significant differences were observed between those with limited cutaneous pattern and controls, whereas patients with diffuse cutaneous pattern displayed substantially increased values. No correlation was found between plasma D-dimer concentration and age, sex, autoantibody pattern, serum creatinine, erythrosedimentation rate, nailfold videocapillaroscopic pattern and pulmonary involvement. Conclusion We demonstrated that SSc patients with diffuse subset are characterized by increased plasma D-dimer values, reflecting a potential activation of both the hemostatic and fibrinolytic cascades, which might finally predispose these patients to thrombotic complications.

  8. Hybrid Plasma Reactor/Filter for Transportable Collective Protection Systems

    Energy Technology Data Exchange (ETDEWEB)

    Josephson, Gary B.; Tonkyn, Russell G.; Frye, J. G.; Riley, Brian J.; Rappe, Kenneth G.

    2011-04-06

    Pacific Northwest National Laboratory (PNNL) has performed an assessment of a Hybrid Plasma/Filter system as an alternative to conventional methods for collective protection. The key premise of the hybrid system is to couple a nonthermal plasma (NTP) reactor with reactive adsorption to provide a broader envelope of protection than can be provided through a single-solution approach. The first step uses highly reactive species (e.g. oxygen radicals, hydroxyl radicals, etc.) created in a nonthermal plasma (NTP) reactor to destroy the majority (~75% - 90%) of an incoming threat. Following the NTP reactor an O3 reactor/filter uses the O3 created in the NTP reactor to further destroy the remaining organic materials. This report summarizes the laboratory development of the Hybrid Plasma Reactor/Filter to protect against a ‘worst-case’ simulant, methyl bromide (CH3Br), and presents a preliminary engineering assessment of the technology to Joint Expeditionary Collective Protection performance specifications for chemical vapor air purification technologies.

  9. Lack of plasma kallikrein-kinin system cascade in teleosts.

    Directory of Open Access Journals (Sweden)

    Marty Kwok-Shing Wong

    Full Text Available The kallikrein-kinin system (KKS consists of two major cascades in mammals: "plasma KKS" consisting of high molecular-weight (HMW kininogen (KNG, plasma kallikrein (KLKB1, and bradykinin (BK; and "tissue KKS" consisting of low molecular-weight (LMW KNG, tissue kallikreins (KLKs, and [Lys(0]-BK. Some components of the KKS have been identified in the fishes, but systematic analyses have not been performed, thus this study aims to define the KKS components in teleosts and pave a way for future physiological and evolutionary studies. Through a combination of genomics, molecular, and biochemical methods, we showed that the entire plasma KKS cascade is absent in teleosts. Instead of two KNGs as found in mammals, a single molecular weight KNG was found in various teleosts, which is homologous to the mammalian LMW KNG. Results of molecular phylogenetic and synteny analyses indicated that the all current teleost genomes lack KLKB1, and its unique protein structure, four apple domains and one trypsin domain, could not be identified in any genome or nucleotide databases. We identified some KLK-like proteins in teleost genomes by synteny and conserved domain analyses, which could be the orthologs of tetrapod KLKs. A radioimmunoassay system was established to measure the teleost BK and we found that [Arg(0]-BK is the major circulating form instead of BK, which supports that the teleost KKS is similar to the mammalian tissue KKS. Coincidently, coelacanths are the earliest vertebrate that possess both HMW KNG and KLKB1, which implies that the plasma KKS could have evolved in the early lobe-finned fish and descended to the tetrapod lineage. The co-evolution of HMW KNG and KLKB1 in lobe-finned fish and early tetrapods may mark the emergence of the plasma KKS and a contact activation system in blood coagulation, while teleosts may have retained a single KKS cascade.

  10. Atmospheric pressure plasma processing of polymeric materials utilizing close proximity indirect exposure

    Science.gov (United States)

    Paulauskas, Felix L.; Bonds, Truman

    2016-09-20

    A plasma treatment method that includes providing treatment chamber including an intermediate heating volume and an interior treatment volume. The interior treatment volume contains an electrode assembly for generating a plasma and the intermediate heating volume heats the interior treatment volume. A work piece is traversed through the treatment chamber. A process gas is introduced to the interior treatment volume of the treatment chamber. A plasma is formed with the electrode assembly from the process gas, wherein a reactive species of the plasma is accelerated towards the fiber tow by flow vortices produced in the interior treatment volume by the electrode assembly.

  11. Real-time communication for distributed plasma control systems

    Energy Technology Data Exchange (ETDEWEB)

    Luchetta, A. [Consorzio RFX, Associazione Euratom-ENEA sulla Fusione, Corso Stati Uniti 4, Padova 35127 (Italy)], E-mail: adriano.luchetta@igi.cnr.it; Barbalace, A.; Manduchi, G.; Soppelsa, A.; Taliercio, C. [Consorzio RFX, Associazione Euratom-ENEA sulla Fusione, Corso Stati Uniti 4, Padova 35127 (Italy)

    2008-04-15

    Real-time control applications will benefit in the near future from the enhanced performance provided by multi-core processor architectures. Nevertheless real-time communication will continue to be critical in distributed plasma control systems where the plant under control typically is distributed over a wide area. At RFX-mod real-time communication is crucial for hard real-time plasma control, due to the distributed architecture of the system, which consists of several VMEbus stations. The system runs under VxWorks and uses Gigabit Ethernet for sub-millisecond real-time communication. To optimize communication in the system, a set of detailed measurements has been carried out on the target platforms (Motorola MVME5100 and MVME5500) using either the VxWorks User Datagram Protocol (UDP) stack or raw communication based on the data link layer. Measurements have been carried out also under Linux, using its UDP stack or, in alternative, RTnet, an open source hard real-time network protocol stack. RTnet runs under Xenomai or RTAI, two popular real-time extensions based on the Linux kernel. The paper reports on the measurements carried out and compares the results, showing that the performance obtained by using open source code is suitable for sub-millisecond real-time communication in plasma control.

  12. Plasma fibrinogen and factor VII concentrations in adults after prenatal exposure to famine

    NARCIS (Netherlands)

    Roseboom, T. J.; van der Meulen, J. H.; Ravelli, A. C.; Osmond, C.; Barker, D. J.; Bleker, O. P.

    2000-01-01

    To assess the effect of maternal malnutrition during different stages of gestation on plasma concentrations of fibrinogen and factor VII, we investigated 725 people, aged 50 years, born around the time of the Dutch famine 1944-5. After adjustment for sex, plasma fibrinogen concentrations differed by

  13. The effect of high-flux H plasma exposure with simultaneous transient heat loads on tungsten surface damage and power handling

    NARCIS (Netherlands)

    van Eden, G. G.; Morgan, T. W.; van der Meiden, H. J.; J Matejicek,; T Chraska,; Wirtz, M.; De Temmerman, G.

    2014-01-01

    The performance of the full-W ITER divertor may be significantly affected by the interplay between steady-state plasma exposure and transient events. To address this issue, the effect of a high-flux H plasma on the thermal shock response of W to ELM-like transients has been investigated. Transient

  14. Associations between plasma concentrations of PCB 28 and possible indoor exposure sources in Danish school children and mothers.

    Science.gov (United States)

    Egsmose, Emilie Lund; Bräuner, Elvira Vaclavik; Frederiksen, Marie; Mørck, Thit Aarøe; Siersma, Volkert Dirk; Hansen, Pernille Winton; Nielsen, Flemming; Grandjean, Philippe; Knudsen, Lisbeth E

    2016-02-01

    Polychlorinated biphenyls (PCBs) are ubiquitously present in the environment and are suspected of carcinogenic, neurotoxic and immunotoxic effects. Significantly higher plasma concentrations of the congener PCB 28 occur in children compared to adults. Exposure in schools may contribute to this difference. To determine whether increased blood plasma concentrations of PCB 28 in Danish school children and mothers are associated with living in homes or attending schools constructed in the PCB period (1959-1977). PCB 28 was analyzed in plasma samples from 116 children aged 6-11years and 143 mothers living in an urban and a rural area in Denmark and participating in the European pilot project DEMOCOPHES (Demonstration of a study to COordinate and Perform Human Biomonitoring on a European Scale). In Denmark, PCBs were used in construction in the period 1950-1977, and year of construction or renovation of the homes and schools was used as a proxy for indoor PCB exposure. Linear regression models were used to assess the association between potential PCB exposure from building materials and lipid adjusted concentrations of PCB 28 in plasma, with and without adjustment for potential confounders. Among the 116 children and 143 mothers, we were able to specify home construction period in all but 4 children and 5 mothers leaving 111 children and 138 mothers for our analyses. The median lipid adjusted plasma PCB 28 concentration was 3 (range: 1-28) ng/g lipid in the children and 2 (range: 1-8) ng/g lipid in the mothers. Children living in homes built in the PCB period had significantly higher lipid adjusted plasma PCB 28 concentrations compared to children living in homes built before or after the PCB period. Following adjustment for covariates, PCB 28 concentrations in children were 40 (95% CI: 13; 68) percent higher than concentrations of children living in homes constructed at other times. Furthermore, children attending schools built or substantially refurbished in the PCB

  15. Plasma equilibria and stationary flows in axisymmetric systems. Pt. 1

    International Nuclear Information System (INIS)

    Zelazny, R.; Stankiewicz, R.; Potempski, S.

    1988-05-01

    During discharges within a tokamak device such as JET fluctuations are observed in the plasma, of plasma density, temperature, electric potential and of the magnetic field. These fluctuations have complicated structure and are linked with different kinds of instabilities. However, it is not clear which instabilities are most important in determining the behaviour of the plasma. A comprehensive numerical theory which can predict the effect of the instabilities on the transport of plasma in axisymmetric systems has been sought using the static Grad-Shafranov-Schlueter (SGSS) equation as a basis. However, the static equation was over simplified for the situation in JET with additional heating giving rise to large toroidal flows, and an extended equation (EGSS) was developed. The results of the study include the discovery of algebraic branches of solutions to the EGSS equation even for very small poloidal flows, solutions to the inverse problem for the SGSS and EGSS equations using Fourier decomposition, classification of the boundary condition at the magnetic axis, demonstration of a visible effect of the poloidal flow on the separation of the density surface and the magnetic surface an indication of the existence of multiple branches of solutions to the EGSS and SGSS equations and their relation to stability properties. (U.K.)

  16. Plasma diffusion in systems with disrupted magnetic surfaces

    International Nuclear Information System (INIS)

    Morozov, D.K.; Pogutse, O.P.

    1982-01-01

    Plasma diffusion is analyzed in the case in which the system of magnetic surfaces is disrupted by a stochastic perturbation of the magnetic field. The diffusion coefficient is related to the statistical properties of the field. The statistical characteristics of the field are found when the magnetic surfaces near the separatrix are disrupted by an external perturbation. The diffusion coefficient is evaluated in the region in which the magnetic surfaces are disrupted. In this region the diffusion coefficient is of the Bohm form

  17. ACREM: A new air crew radiation exposure measuring system

    International Nuclear Information System (INIS)

    Beck, P.; Duftschmid, K.; Kerschbaumer, S.; Schmitzer, C.; Strachotinsky, C.; Grosskopf, A.; Winkler, N.

    1996-01-01

    Cosmic radiation has already been discovered in 1912 by the Austrian Nobel Laureate Victor F. Hess. After Hess up to now numerous measurements of the radiation exposure by cosmic rays in different altitudes have been performed, however, this has not been taken serious in view of radiation protection.Today, with the fast development of modern airplanes, an ever increasing number of civil aircraft is flying in increasing altitudes for considerable time. Members of civil aircrew spending up to 1000 hours per year in cruising altitudes and therefore are subject to significant levels of radiation exposure. In 1990 ICRP published its report ICRP 60 with updated excess cancer risk estimates, which led to significantly higher risk coefficients for some radiation qualities. An increase of the radiation weighting factors for mean energy neutron radiation increases the contribution for the neutron component to the equivalent dose by about 60%, as compared to the earlier values of ICRP26. This higher risk coefficients lead to the recommendation of the ICRP, that cosmic radiation exposure in civil aviation should be taken into account as occupational exposure. Numerous recent exposure measurements at civil airliners in Germany, Sweden, USA, and Russia show exposure levels in the range of 3-10 mSv/year. This is significantly more than the average annual dose of radiation workers (in Austria about 1.5 mSv/year). Up to now no practicable and economic radiation monitoring system for routine application on board exits. A fairly simple and economic approach to a practical, active in-flight dosimeter for the assessment of individual crew exposure is discussed in this paper

  18. Biomarkers of oxidative stress study V: ozone exposure of rats and its effect on lipids, proteins, and DNA in plasma and urine.

    Science.gov (United States)

    Kadiiska, Maria B; Basu, Samar; Brot, Nathan; Cooper, Christopher; Saari Csallany, A; Davies, Michael J; George, Magdalene M; Murray, Dennis M; Jackson Roberts, L; Shigenaga, Mark K; Sohal, Rajindar S; Stocker, Roland; Van Thiel, David H; Wiswedel, Ingrid; Hatch, Gary E; Mason, Ronald P

    2013-08-01

    Ozone exposure effect on free radical-catalyzed oxidation products of lipids, proteins, and DNA in the plasma and urine of rats was studied as a continuation of the international Biomarker of Oxidative Stress Study (BOSS) sponsored by NIEHS/NIH. The goal was to identify a biomarker for ozone-induced oxidative stress and to assess whether inconsistent results often reported in the literature might be due to the limitations of the available methods for measuring the various types of oxidative products. The time- and dose-dependent effects of ozone exposure on rat plasma lipid hydroperoxides, malondialdehyde, F2-isoprostanes, protein carbonyls, methionine oxidation, and tyrosine- and phenylalanine oxidation products, as well as urinary malondialdehyde and F2-isoprostanes were investigated with various techniques. The criterion used to recognize a marker in the model of ozone exposure was that a significant effect could be identified and measured in a biological fluid seen at both doses at more than one time point. No statistically significant differences between the experimental and the control groups at either ozone dose and time point studied could be identified in this study. Tissue samples were not included. Despite all the work accomplished in the BOSS study of ozone, no available product of oxidation in biological fluid has yet met the required criteria of being a biomarker. The current negative findings as a consequence of ozone exposure are of great importance, because they document that in complex systems, as the present in vivo experiment, the assays used may not provide meaningful data of ozone oxidation, especially in human studies. Published by Elsevier Inc.

  19. Human reproductive system disturbances and pesticide exposure in Brazil

    Directory of Open Access Journals (Sweden)

    Koifman Sergio

    2002-01-01

    Full Text Available The observation of reproductive disturbances in humans and in the wildlife has been reported in the last decade in different countries. Exposure to different chemicals possibly acting in the endocrine system or endocrine disruptors, including pesticides, has been a hypothesis raised to explain the observed changes. This paper aimed to present results of an epidemiological ecologic study carried out to explore population data on pesticides exposure in selected Brazilian states in the eighties and human reproductive outcomes in the nineties. Pearson correlation coefficients were ascertained between available data pesticides sales in eleven states in Brazil in 1985 and selected further reproductive outcomes or their surrogates. Moderate to high correlations were observed to infertility, testis, breast, prostate and ovarian cancer mortality. Despite the restrains of ecologic studies to establish cause-effect relationships, the observed results are in agreement with evidence supporting a possible association between pesticides exposure and the analyzed reproductive outcomes.

  20. Prenatal Alcohol Exposure and the Developing Immune System.

    Science.gov (United States)

    Gauthier, Theresa W

    2015-01-01

    Evidence from research in humans and animals suggest that ingesting alcohol during pregnancy can disrupt the fetal immune system and result in an increased risk of infections and disease in newborns that may persist throughout life. Alcohol may have indirect effects on the immune system by increasing the risk of premature birth, which itself is a risk factor for immune-related problems. Animal studies suggest that alcohol exposure directly disrupts the developing immune system. A comprehensive knowledge of the mechanisms underlying alcohol's effects on the developing immune system only will become clear once researchers establish improved methods for identifying newborns exposed to alcohol in utero.

  1. Properties of waves in an ion-beam plasma system

    International Nuclear Information System (INIS)

    Zank, G.P.; McKenzie, J.F.

    1988-01-01

    A multi-fluid approach is used to describe electrostatic interactions in an ion-beam plasma system. The structure of the wave equation governing the system exhibits the anisotropic and dispersive nature of the waves, whose properties are analysed in terms of the dispersion relation. The main purpose is to classify the different waves that can arise in an ion-beam plasma system in a systematic fashion. The classification is facilitated by introducing a three-parameter CMA diagram that illustrates the topological changes in not only the wavenumber, or refractive-index, surface but also the ray-velocity surface. Furthermore, an analytic expression governing wave amplification in an ion beam plasma is incorporated within the framework of a generalized CMA diagram. Such a description provides a simple interpretation for the onset of wave amplification in terms of a topological change in the refractive-index surface. It is hoped that by collating the wave properties in a unified form, many of the complicated wave features observed in an experiment may be interpreted more easily. (author)

  2. Amotosalen: Allogeneic Cellular Immunotherapies system, INTERCEPT Plasma System, INTERCEPT Platelet System, S 59.

    Science.gov (United States)

    2003-01-01

    Adis CommentsCerus Corporation is developing a variety of pathogen-inactivation systems, based on its Helinx technology. Three of the systems include amotosalen [S 59] as the inactivation compound. Amotosalen is a light-activated, DNA-, RNA-crosslinking psoralen compound, which is used to neutralise pathogens. The systems that utilise amotosalen are called the INTERCEPT Platelet System, the INTERCEPT Plasma System and the Allogeneic Cellular Immunotherapies (ACIT) system. The INTERCEPT Platelet System and INTERCEPT Plasma System are two of the systems that make up Cerus' INTERCEPT Blood Systems. The other system is the INTERCEPT Red Blood Cell System, which contains S 303 as the inactivation compound rather than amotosalen. Cerus' Helinx technology is able to prevent replication of DNA or RNA that is present in pathogens but not in the blood components being treated (e.g. platelets and plasma). When added to the blood components, the inactivation agent (in this case amotosalen) crosses the membrane or cell wall of the pathogen. When activated by light, amotosalen binds to the nucleic acid of the pathogen and prevents replication. This process prevents infection. INTERCEPT Platelet System: Cerus developed its INTERCEPT Platelet System, in collaboration with Baxter Healthcare, for use in blood centres. Platelets are an essential component of the coagulation process and may be required by patients undergoing surgery, cancer chemotherapy, transplantation or with bleeding disorders. The system is made up of an illuminator device, a compound absorption device and a processing kit containing amotosalen. In October 2002, the two companies announced that CE Mark approval had been received for the illuminator device for the INTERCEPT trade mark Blood System. Application of this technology to platelets is the first to be approved. As it is a new technology, the system is currently undergoing process validation in accordance with European Blood Bank GMP requirements. This

  3. Isoe - information system on occupational exposure. Ten years of experience

    International Nuclear Information System (INIS)

    2002-01-01

    The information System on Occupational Exposure (ISOE) was created in 1992 to provide a forum for radiation protection experts from both utilities and national regulatory authorities to discuss, promote and co-ordinate international co-operative undertakings in the area of worker protection at nuclear power plants. The ISOE System is jointly managed by the OECD Nuclear Energy Agency (NEA) and the International Atomic Energy Agency (IAEA). This report provides an overview of the experience gained from, and benefits provided by, the ISOE System over the past ten years. Active participation of a large number of utilities in ISOE has contributed to a reduction in occupational exposure at nuclear power plants worldwide. (authors)

  4. Recovery of Tungsten Surface with Fiber-Form Nanostructure by Plasmas Exposures

    International Nuclear Information System (INIS)

    Miyamoto, Takanori; Takamura, Shuichi; Kurishita, Hiroaki

    2013-01-01

    One of the serious concerns for tungsten materials in fusion devices is the radiation defects caused by helium plasma irradiation since helium is a fusion product. The fiber-formed nanostructure is thought to have a possible weakness against the plasma heat flux on the plasma-facing component and also may destroy the reflectivity of optical mirrors. In this paper an interesting method for the recovery of such tungsten surfaces is shown. The recovery process depends on the grade and manufacturing process of tungsten materials. (fusion engineering)

  5. Design and Architecture of SST-1 basic plasma control system

    Energy Technology Data Exchange (ETDEWEB)

    Patel, Kirit, E-mail: kpatel@ipr.res.in; Raju, D.; Dhongde, J.; Mahajan, K.; Chudasama, H.; Gulati, H.; Chauhan, A.; Masand, H.; Bhandarkar, M.; Pradhan, S.

    2016-11-15

    Highlights: • Reflective Memory network. • FPAG based Timing system for trigger distribution. • IRIG-B network for GPS time synchronization. • PMC based Digital Signal Processors and VME. • Simultaneous sampling ADC. - Abstract: Primary objective of SST-1 Plasma control system is to achieve Plasma position, shape and current profile control. Architecture of control system for SST-1 is distributed in nature. Fastest control loop time requirement of 100 μs is achieved using VME based simultaneous sampling ADCs, PMC based quad core DSP, Reflective Memory [RFM] based real-time network, VME based real-time trigger distribution network and Ethernet network. All the control loops for shape control, position control and current profile control share common signals from Magnetic diagnostic so it is planned to accommodate all the algorithms on the same PMC based quad core DSP module TS C-43. RFM based real-time data network replicate data from one node to next node in a ring network topology at sustained throughput rate of 13.4 MBps. Real-time Timing System network provides guaranteed trigger distribution in 3.8 μs from one node to all node of the network. Monitoring and configuration of different systems participating in the operation of SST-1 is done by Ethernet network. Magnetic sensors data is acquired using Pentek 6802 simultaneously sampling ADC card at the rate of 10KSPS. All the real-time raw data along with the control data will be archived using RFM network and SCSI HDD for the experiment duration of 1000 s. RFM network is also planned for real-time plotting of key parameter of Plasma during long experiment. After experiment this data is transferred to central storage server for archival purpose. This paper discusses the architecture and hardware implementation of the control system by describing all the involved hardware and software along with future plans for up-gradations.

  6. Software development for the PBX-M plasma control system

    International Nuclear Information System (INIS)

    Lagin, L.; Bell, R.; Chu, J.; Hatcher, R.; Hirsch, J.; Okabayashi, M.; Sichta, P.

    1995-01-01

    This paper describes the software development effort for the PBX-M plasma control system. The algorithms being developed for the system will serve to test advanced control concepts for TPX and ITER. This will include real-time algorithms for shaping control, vertical position control, current and density profile control and MHD avoidance. The control system consists of an interactive Host Processor (SPARC-10) interfaced through VME with four real-time Computer Processors (i860) which run at a maximum computational speed of 320 MFLOPs. Plasma shaping programs are being tested to duplicate the present PBX-M analog control system. Advanced algorithms for vertical control and x-point control will then be developed. Interactive graphical user interface programs running on the Host Processor will allow operators to control and monitor shot parameters. A waveform edit program will be used to download pre-programmed waveforms into the Compute Processor memory. Post-shot display programs will be used to interactively display data after the shot. Automatic pre-shot arming and data acquisition programs will run on the Host Processor. Event system programs will process interrupts and activate programs on the Host and Compute Processors. These programs are being written in C and Fortran and use system service routines to communicate with the Compute Processors and its memory. IDL and IDL widgets are being used to build the graphical user interfaces

  7. Electrodeless plasma acceleration system using rotating magnetic field method

    Directory of Open Access Journals (Sweden)

    T. Furukawa

    2017-11-01

    Full Text Available We have proposed Rotating Magnetic Field (RMF acceleration method as one of electrodeless plasma accelerations. In our experimental scheme, plasma generated by an rf (radio frequency antenna, is accelerated by RMF antennas, which consist of two-pair, opposed, facing coils, and these antennas are outside of a discharge tube. Therefore, there is no wear of electrodes, degrading the propulsion performance. Here, we will introduce our RMF acceleration system developed, including the experimental device, e.g., external antennas, a tapered quartz tube, a vacuum chamber, external magnets, and a pumping system. In addition, we can change RMF operation parameters (RMF applied current IRMF and RMF current phase difference ϕ, focusing on RMF current frequency fRMF by adjusting matching conditions of RMF, and investigate the dependencies on plasma parameters (electron density ne and ion velocity vi; e.g., higher increases of ne and vi (∼360 % and 55 %, respectively than previous experimental results were obtained by decreasing fRMF from 5 MHz to 0.7 MHz, whose RMF penetration condition was better according to Milroy’s expression. Moreover, time-varying component of RMF has been measured directly to survey the penetration condition experimentally.

  8. Fields and plasmas in the outer solar system. [Review

    Energy Technology Data Exchange (ETDEWEB)

    Smith, E J [Jet Propulsion Lab., Pasadena, CA (USA); Wolfe, J H [National Aeronautics and Space Administration, Moffett Field, CA (USA). Ames Research Center

    1979-04-01

    The most significant information about fields and plasmas in the outer solar system, based on observations by Pioneer 10 and 11 investigations, is reviewed. The characteristic evolution of solar wind streams beyond 1 AU has been observed. The region within which the velocity increases continuously near 1 AU is replaced at larger distances by a thick interaction region with abrupt jumps in the solar wind speed at the leading and trailing edges. These abrupt increases, accompanied by corresponding jumps in the field magnitude and in the solar wind density and temperature, consist typically of a forward and a reverse shock. The existance of two distinct corotating regions, separated by sharp boundaries, is a characteristic feature of the interplanetary medium in the outer solar system. Within the interaction regions, compression effects are dominant and the field strength, plasma density, plasma temperature and the level of fluctuations are enhanced. Within the intervening quiet regions, rarefaction effects dominante and the field magnitude, solar wind density and fluctuation level are very low. These changes in the structure of interplanetary space have significant consequences for the many energetic particles propagating through the medium.

  9. New achievements in the EAST plasma control system

    Energy Technology Data Exchange (ETDEWEB)

    Yuan, Q.P., E-mail: qpyuan@ipp.ac.c [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei (China); Xiao, B.J. [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei (China); Penaflor, B.G.; Piglowski, D.A. [General Atomics, DIII-D National Fusion Facility, San Diego, CA (United States); Liu, L.Z. [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei (China); Johnson, R.D.; Walker, M.L.; Humphreys, D.A. [General Atomics, DIII-D National Fusion Facility, San Diego, CA (United States)

    2010-07-15

    In order to realize the low latency and distortion-free signal transmission between the plasma control system (PCS) and servo systems, the digital output structure configured with reflective memory board (RFM) was adopted in EAST PCS. And the enhanced performances are reported. Another achievement made in the latest EAST PCS was the implementation of density control algorithm, which controlled the line average density in either voltage or width modulation mode. The new integrated algorithm improved the precision of density calculation and control performance greatly. The details and experiment results are presented in this paper.

  10. Sublethal red tide toxin exposure in free-ranging manatees (Trichechus manatus) affects the immune system through reduced lymphocyte proliferation responses, inflammation, and oxidative stress

    International Nuclear Information System (INIS)

    Walsh, Catherine J.; Butawan, Matthew; Yordy, Jennifer; Ball, Ray; Flewelling, Leanne; Wit, Martine de; Bonde, Robert K.

    2015-01-01

    Highlights: • Sublethal brevetoxin exposure affects manatee immune function. • Plasma brevetoxin levels correlate with oxidative stress in rescued manatees. • Brevetoxin exposure affects lymphocyte proliferation in rescued manatees. • Plasma brevetoxin concentrations ranged from 0 to 19 ng PbTx-3 eq/mL. - Abstract: The health of many Florida manatees (Trichechus manatus latirostris) is adversely affected by exposure to blooms of the toxic dinoflagellate, Karenia brevis. K. brevis blooms are common in manatee habitats of Florida’s southwestern coast and produce a group of cyclic polyether toxins collectively referred to as red tide toxins, or brevetoxins. Although a large number of manatees exposed to significant levels of red tide toxins die, several manatees are rescued from sublethal exposure and are successfully treated and returned to the wild. Sublethal brevetoxin exposure may potentially impact the manatee immune system. Lymphocyte proliferative responses and a suite of immune function parameters in the plasma were used to evaluate effects of brevetoxin exposure on health of manatees rescued from natural exposure to red tide toxins in their habitat. Blood samples were collected from rescued manatees at Lowry Park Zoo in Tampa, FL and from healthy, unexposed manatees in Crystal River, FL. Peripheral blood leukocytes (PBL) isolated from whole blood were stimulated with T-cell mitogens, ConA and PHA. A suite of plasma parameters, including plasma protein electrophoresis profiles, lysozyme activity, superoxide dismutase (SOD) activity, and reactive oxygen/nitrogen (ROS/RNS) species, was also used to assess manatee health. Significant decreases (p < 0.05) in lymphocyte proliferation were observed in ConA and PHA stimulated lymphocytes from rescued animals compared to non-exposed animals. Significant correlations were observed between oxidative stress markers (SOD, ROS/RNS) and plasma brevetoxin concentrations. Sublethal exposure to brevetoxins in the

  11. Sublethal red tide toxin exposure in free-ranging manatees (Trichechus manatus) affects the immune system through reduced lymphocyte proliferation responses, inflammation, and oxidative stress

    Energy Technology Data Exchange (ETDEWEB)

    Walsh, Catherine J., E-mail: cjwalsh@mote.org [Marine Immunology Program, Mote Marine Laboratory, 1600 Ken Thompson Parkway, Sarasota, FL 34236 (United States); Butawan, Matthew, E-mail: mattbutawan@outlook.com [Marine Immunology Program, Mote Marine Laboratory, 1600 Ken Thompson Parkway, Sarasota, FL 34236 (United States); Yordy, Jennifer, E-mail: jennifer.e.balmer@gmail.com [Marine Immunology Program, Mote Marine Laboratory, 1600 Ken Thompson Parkway, Sarasota, FL 34236 (United States); Ball, Ray, E-mail: Ray.Ball@lowryparkzoo.com [Lowry Park Zoo, 1101 W Sligh Ave, Tampa, FL 33604 (United States); Flewelling, Leanne, E-mail: Leanne.Flewelling@MyFWC.com [Fish and Wildlife Research Institute, Florida Fish and Wildlife Conservation Commission, 100 8th Ave SE, St. Petersburg, FL 33701 (United States); Wit, Martine de, E-mail: Martine.deWit@MyFWC.com [Fish and Wildlife Research Institute, Florida Fish and Wildlife Conservation Commission, 100 8th Ave SE, St. Petersburg, FL 33701 (United States); Bonde, Robert K., E-mail: rbonde@usgs.gov [U.S. Geological Survey, Sirenia Project, 7920 NE 71st Street, Gainesville, FL 32653 (United States)

    2015-04-15

    Highlights: • Sublethal brevetoxin exposure affects manatee immune function. • Plasma brevetoxin levels correlate with oxidative stress in rescued manatees. • Brevetoxin exposure affects lymphocyte proliferation in rescued manatees. • Plasma brevetoxin concentrations ranged from 0 to 19 ng PbTx-3 eq/mL. - Abstract: The health of many Florida manatees (Trichechus manatus latirostris) is adversely affected by exposure to blooms of the toxic dinoflagellate, Karenia brevis. K. brevis blooms are common in manatee habitats of Florida’s southwestern coast and produce a group of cyclic polyether toxins collectively referred to as red tide toxins, or brevetoxins. Although a large number of manatees exposed to significant levels of red tide toxins die, several manatees are rescued from sublethal exposure and are successfully treated and returned to the wild. Sublethal brevetoxin exposure may potentially impact the manatee immune system. Lymphocyte proliferative responses and a suite of immune function parameters in the plasma were used to evaluate effects of brevetoxin exposure on health of manatees rescued from natural exposure to red tide toxins in their habitat. Blood samples were collected from rescued manatees at Lowry Park Zoo in Tampa, FL and from healthy, unexposed manatees in Crystal River, FL. Peripheral blood leukocytes (PBL) isolated from whole blood were stimulated with T-cell mitogens, ConA and PHA. A suite of plasma parameters, including plasma protein electrophoresis profiles, lysozyme activity, superoxide dismutase (SOD) activity, and reactive oxygen/nitrogen (ROS/RNS) species, was also used to assess manatee health. Significant decreases (p < 0.05) in lymphocyte proliferation were observed in ConA and PHA stimulated lymphocytes from rescued animals compared to non-exposed animals. Significant correlations were observed between oxidative stress markers (SOD, ROS/RNS) and plasma brevetoxin concentrations. Sublethal exposure to brevetoxins in the

  12. Systems for animal exposure in full-scale fire tests

    Science.gov (United States)

    Hilado, C. J.; Cumming, H. J.; Kourtides, D. A.; Parker, J. A.

    1977-01-01

    Two systems for exposing animals in full-scale fire tests are described. Both systems involve the simultaneous exposure of two animal species, mice and rats, in modular units; determination of mortality, morbidity, and behavioral response; and analysis of the blood for carboxyhemoglobin. The systems described represent two of many possible options for obtaining bioassay data from full-scale fire tests. In situations where the temperatures to which the test animals are exposed can not be controlled, analytical techniques may be more appropriate than bioassay techniques.

  13. Mobilisation of heavy metals into the urine by CaEDTA: relation to erythrocyte and plasma concentrations and exposure indicators.

    OpenAIRE

    Araki, S; Aono, H; Murata, K

    1986-01-01

    To investigate the effects of calcium disodium ethylenediamine tetra-acetate (CaEDTA) on the urinary excretion, erythrocyte, and plasma concentrations and exposure indicators of seven heavy metals, CaEDTA was administered by intravenous infusion to 20 workers exposed to lead, zinc, and copper. The workers' blood lead concentrations ranged from 22 to 59 micrograms/dl (mean 38 micrograms/dl (1.8 mumol/l]. The 24 hour urinary excretion of metals after CaEDTA administration (mobilisation yield) w...

  14. Characteristics of semiconductor bridge (SCB) plasma generated in a micro-electro-mechanical system (MEMS)

    International Nuclear Information System (INIS)

    Kim, Jong-Uk; Park, Chong-Ook; Park, Myung-Il; Kim, Sun-Hwan; Lee, Jung-Bok

    2002-01-01

    Plasma ignition method has been applied in various fields particularly to the rocket propulsion, pyrotechnics, explosives, and to the automotive air-bag system. Ignition method for those applications should be safe and also operate reliably in hostile environments such as; electromagnetic noise, drift voltage, electrostatic background and so on. In the present Letter, a semiconductor bridge (SCB) plasma ignition device was fabricated and its plasma characteristics including the propagation speed of the plasma, plasma size, and plasma temperature were investigated with the aid of the visualization of micro scale plasma (i.e., ≤350 μm), which generated from a micro-electro-mechanical poly-silicon semiconductor bridge (SCB)

  15. Sustainability of a public system for plasma collection, contract fractionation and plasma-derived medicinal product manufacturing.

    Science.gov (United States)

    Grazzini, Giuliano; Ceccarelli, Anna; Calteri, Deanna; Catalano, Liviana; Calizzani, Gabriele; Cicchetti, Americo

    2013-09-01

    In Italy, the financial reimbursement for labile blood components exchanged between Regions is regulated by national tariffs defined in 1991 and updated in 1993-2003. Over the last five years, the need for establishing standard costs of healthcare services has arisen critically. In this perspective, the present study is aimed at defining both the costs of production of blood components and the related prices, as well as the prices of plasma-derived medicinal products obtained by national plasma, to be used for interregional financial reimbursement. In order to analyse the costs of production of blood components, 12 out 318 blood establishments were selected in 8 Italian Regions. For each step of the production process, driving costs were identified and production costs were. To define the costs of plasma-derived medicinal products obtained by national plasma, industrial costs currently sustained by National Health Service for contract fractionation were taken into account. The production costs of plasma-derived medicinal products obtained from national plasma showed a huge variability among blood establishments, which was much lower after standardization. The new suggested plasma tariffs were quite similar to those currently in force. Comparing the overall costs theoretically sustained by the National Health Service for plasma-derived medicinal products obtained from national plasma to current commercial costs, demonstrates that the national blood system could gain a 10% cost saving if it were able to produce plasma for fractionation within the standard costs defined in this study. Achieving national self-sufficiency through the production of plasma-derived medicinal products from national plasma, is a strategic goal of the National Health Service which must comply not only with quality, safety and availability requirements but also with the increasingly pressing need for economic sustainability.

  16. Radon exposure and tumors of the central nervous system.

    Science.gov (United States)

    Ruano-Ravina, Alberto; Dacosta-Urbieta, Ana; Barros-Dios, Juan Miguel; Kelsey, Karl T

    2017-03-15

    To review the published evidence of links between radon exposure and central nervous system tumors through a systematic review of the scientific literature. We performed a thorough bibliographic search in Medline (PubMed) and EMBASE. We combined MeSH (Medical Subject Heading) terms and free text. We developed a purpose-designed scale to assess the quality of the included manuscripts. We have included 18 studies, 8 performed on miners, 3 on the general population and 7 on children, and the results have been structured using this classification. The results are inconclusive. An association between radon exposure and central nervous system tumors has been observed in some studies on miners, but not in others. The results observed in the general adult population and in children are also mixed, with some research evincing a statistically significant association and others showing no effect. We cannot conclude that there is a relationship between radon exposure and central nervous system tumors. The available studies are extremely heterogeneous in terms of design and populations studied. Further research is needed in this topic, particularly in the general population residing in areas with high levels of radon. Copyright © 2017 SESPAS. Publicado por Elsevier España, S.L.U. All rights reserved.

  17. Low level exposure to chemicals and immune system

    International Nuclear Information System (INIS)

    Colosio, C.; Birindelli, S.; Corsini, E.; Galli, C.L.; Maroni, M.

    2005-01-01

    Industrialized countries are facing an increase of diseases attributable to an alteration of the immune system function, and concern is growing that this trend could be at least partially attributable to new and modified patterns of exposure to chemicals. Among chemicals matter of concern, pesticides can be included. The Authors have reviewed the existing evidence of pesticide immunotoxicity in humans, showing that existing data are inadequate to raise conclusions on the immunotoxic risk related to these compounds. The limits of existing studies are: poor knowledge on exposure levels, heterogeneity of the approach, and difficulty in giving a prognostic significance to the slight changes often observed. To overcome these limits, the Authors have proposed a tier approach, based on three steps: the first, addressed at pointing out a possible immunomodulation; the second, at refining the results and the third one, when needed, to finalize the study and to point out concordance with previous results. Studies should preferably be carried out through comparison of pre- and post-exposure findings in the same groups of subjects to be examined immediately after the end of the exposure. A simplification of the first step approach can be used by the occupational health physician and the occupational toxicologist. Conclusions on the prognostic significance of the slight changes often observed will be reached only by validating the hypothesis generated by field studies with an epidemiological approach. In this field, the most useful option is represented by longitudinal perspective studies

  18. Status of the new WEST plasma control system

    International Nuclear Information System (INIS)

    Ravene, Nathalie; Nouailletas, Rémy; Signoret, Jacqueline; Guillerminet, Bernard; Treutterrer, Wolfgang; Spring, Anett; Masand, Harish; Dhongde, Jasraj; Bhandarkar, Manisha; Rapson, Chris; Laqua, Heike; Lewerentz, Marc; Moreau, Philippe; Brémond, Sylvain; Allegretti, Ludovic; Raupp, Gerhard; Werner, Andreas; Laurent, François Saint; Nardon, Eric

    2016-01-01

    The WEST (W – for Tungsten – Environment in Steady state Tokamak) project is aiming at minimizing technology and operational risks of a full tungsten actively cooled divertor on ITER. It was started in 2013 and consists in transforming the Tore Supra tokamak into an X point divertor device, while taking advantage of its long discharge capability. To operate the next coming operations of WEST, new controllers are required. These developments are an opportunity to develop a new Plasma Control System (PCS) architecture featuring build-in real time handling of both plasma and plants events, thus addressing key ITER needs. The Tore Supra PCS will be refurbished including a new Pulse Schedule Editor (PSE). The main idea is to use a time segmented approach to describe the pulse schedule with a full integration of event handling both on PCS and PSE. Further to detailed requirement specifications and architecture design, two software tools were selected to define and execute a whole plasma discharge defined as a set of time segments. The PCS real-time framework (RTF) is based on an upgraded version of the AUG framework, called DCS (Discharge Control System). The PSE is the Xedit application used on WEGA and under further development for W7-X facility. This paper reports on the status of the new WEST PCS developments. The on-going developments to adapt DCS to the Tore Supra Control infrastructure networks (new real-time network, chronology system and pulse supervision) will be reported. The required preparations for the use of Xedit will be presented, mainly the appropriate formal description of the WEST control system and the implementation of the mapping between the Xedit experiment configuration and DCS configuration files.

  19. Status of the new WEST plasma control system

    Energy Technology Data Exchange (ETDEWEB)

    Ravene, Nathalie, E-mail: nathalie.ravenel@gmail.com [IRFM, CEA, F-13108 Saint Paul lez Durance (France); Nouailletas, Rémy; Signoret, Jacqueline; Guillerminet, Bernard [IRFM, CEA, F-13108 Saint Paul lez Durance (France); Treutterrer, Wolfgang [Max-Planck-Institut für Plasmaphysik, Boltzmannstraße 2, 85748 Garching (Germany); Spring, Anett [Max-Planck-Institut für Plasmaphysik, Teilinstitut Greifswald, Wendelsteinstraße 1, D-17491 Greifswald (Germany); Masand, Harish; Dhongde, Jasraj; Bhandarkar, Manisha [Institute for Plasma Research (IPR), Near Indira Bridge, Bhat, Gandhinagar, 382 428 Gujarat (India); Rapson, Chris [Max-Planck-Institut für Plasmaphysik, Boltzmannstraße 2, 85748 Garching (Germany); Laqua, Heike; Lewerentz, Marc [Max-Planck-Institut für Plasmaphysik, Teilinstitut Greifswald, Wendelsteinstraße 1, D-17491 Greifswald (Germany); Moreau, Philippe; Brémond, Sylvain; Allegretti, Ludovic [IRFM, CEA, F-13108 Saint Paul lez Durance (France); Raupp, Gerhard [Max-Planck-Institut für Plasmaphysik, Boltzmannstraße 2, 85748 Garching (Germany); Werner, Andreas [Max-Planck-Institut für Plasmaphysik, Teilinstitut Greifswald, Wendelsteinstraße 1, D-17491 Greifswald (Germany); Laurent, François Saint; Nardon, Eric [IRFM, CEA, F-13108 Saint Paul lez Durance (France)

    2016-11-15

    The WEST (W – for Tungsten – Environment in Steady state Tokamak) project is aiming at minimizing technology and operational risks of a full tungsten actively cooled divertor on ITER. It was started in 2013 and consists in transforming the Tore Supra tokamak into an X point divertor device, while taking advantage of its long discharge capability. To operate the next coming operations of WEST, new controllers are required. These developments are an opportunity to develop a new Plasma Control System (PCS) architecture featuring build-in real time handling of both plasma and plants events, thus addressing key ITER needs. The Tore Supra PCS will be refurbished including a new Pulse Schedule Editor (PSE). The main idea is to use a time segmented approach to describe the pulse schedule with a full integration of event handling both on PCS and PSE. Further to detailed requirement specifications and architecture design, two software tools were selected to define and execute a whole plasma discharge defined as a set of time segments. The PCS real-time framework (RTF) is based on an upgraded version of the AUG framework, called DCS (Discharge Control System). The PSE is the Xedit application used on WEGA and under further development for W7-X facility. This paper reports on the status of the new WEST PCS developments. The on-going developments to adapt DCS to the Tore Supra Control infrastructure networks (new real-time network, chronology system and pulse supervision) will be reported. The required preparations for the use of Xedit will be presented, mainly the appropriate formal description of the WEST control system and the implementation of the mapping between the Xedit experiment configuration and DCS configuration files.

  20. Parametric instabilities in an electron beam plasma system

    International Nuclear Information System (INIS)

    Nakach, R.; Cuperman, S.; Gell, Y.; Levush, B.

    1981-01-01

    The excitation of low frequency parametric instabilities by a finite wave length pump in a system consisting of a warm electron plasma traversed by a warm electron beam is investigated in a fluid dissipationless model. The dispersion relation for the three-dimensional problem in a magnetized plasma with arbitrary directions for the waves is derived, and the one-dimensional case is analyzed numerically. For the one-dimensional back-scattering decay process, it is found that when the plasma-electron Debye length (lambda sub(D)sup(p)) is larger than the beam-electron Debye length (lambda sub(D)sup(b)), two low frequency electrostatic instability branches with different growth rates may simultaneously exist. When lambda sub(D)sup(p) approximately lambda sub(D)sup(b), the large growth rate instability found in the analysis depends strongly on the amplitude of the pump field. In the case (lambda sub(D)sup(p) < lambda sub(D)sup(b)) only one low frequency instability branch is generally excited

  1. Optical diagnosis system for intense electron beam diode plasma

    International Nuclear Information System (INIS)

    Yang Jie; Shu Ting; Zhang Jun; Fan Yuwei; Yang Jianhua; Liu Lie; Yin Yi; Luo Ling

    2012-01-01

    A nanosecond time-resolved imaging platform for diode plasmas diagnostics has been constructed based on the pulsed electron beam accelerator and high speed framing camera (HSFC). The accelerator can provide an electrical pulse with voltages of 200-500 kV, rise-time (from 10% to 90% amplitude) of 25 ns and duration of 110 ns. The diode currents up to kA level can be extracted. The trigger signal for camera was picked up by a water-resistor voltage divider after the main switch of the accelerator, which could avoid the disadvantageous influence of the time jitter caused by the breakdown of the gas gaps. Then the sampled negative electrical pulse was converted into a transistor-transistor logic (TTL) signal (5 V) with rise time of about 1.5 ns and time jitter less than 1 ns via a processor. And this signal was taken as the synchronization time base. According to the working characteristics of the camera, the synchronization scheme relying mainly on electrical pulse delay method supplemented by light signal delay method was determined to make sure that the camera can work synchronously with the light production and transportation from the diode plasma within the time scale of nanosecond. Moreover, shielding and filtering methods were used to restrain the interference on the measurement system from the accelerator. Finally, time resolved 2-D framing images of the diode plasma were acquired. (authors)

  2. Modular Pulsed Plasma Electric Propulsion System for Cubesats

    Science.gov (United States)

    Perez, Andres Dono; Gazulla, Oriol Tintore; Teel, George Lewis; Mai, Nghia; Lukas, Joseph; Haque, Sumadra; Uribe, Eddie; Keidar, Michael; Agasid, Elwood

    2014-01-01

    Current capabilities of CubeSats must be improved in order to perform more ambitious missions. Electric propulsion systems will play a key role due to their large specific impulse. Compared to other propulsion alternatives, their simplicity allows an easier miniaturization and manufacturing of autonomous modules into the nano and pico-satellite platform. Pulsed Plasma Thrusters (PPTs) appear as one of the most promising technologies for the near term. The utilization of solid and non-volatile propellants, their low power requirements and their proven reliability in the large scale make them great candidates for rapid implementation. The main challenges are the integration and miniaturization of all the electronic circuitry into a printed circuit board (PCB) that can satisfy the strict requirements that CubeSats present. NASA Ames and the George Washington University have demonstrated functionality and control of three discrete Micro-Cathode Arc Thrusters (CAT) using a bench top configuration that was compatible with the ARC PhoneSat Bus. This demonstration was successfully conducted in a vaccum chamber at the ARC Environmental Test Laboratory. A new effort will integrate a low power Plasma Processing Unit and two plasma thrusters onto a single printed circuit board that will utilize less than 13 U of Bus volume. The target design will be optimized for the accommodation into the PhoneSatEDISON Demonstration of SmallSatellite Networks (EDSN) bus as it uses the same software interface application, which was demonstrated in the previous task. This paper describes the design, integration and architecture of the proposed propulsion subsystem for a planned Technology Demonstration Mission. In addition, a general review of the Pulsed Plasma technology available for CubeSats is presented in order to assess the necessary challenges to overcome further development.

  3. External radiation exposure control system in accelerator facilities

    International Nuclear Information System (INIS)

    Ogawa, Tatsuhiko; Iimoto, Takeshi; Kosako, Toshiso

    2011-01-01

    The external exposure control systems in KEK and CERN are discussed to find out good practices and unreasonableness of radiation control in accelerator facilities, which plays an important role in optimizing national and/or site specific radiological regulations, referring to relevant ICRP publications. Personal dose limits and radiation area classifications were analyzed and their reasonableness were explored. Good example of supervised areas, area classification based on realistic assumptions on working time etc are found. On the other hand, unreasonable systems, that are often attributed to the national regulation or ideas presented in the old publications are also found. (author)

  4. Gravimetrical and chemical characterization of SiOx structures deposited on fine powders by short plasma exposure in a plasma down stream reactor

    International Nuclear Information System (INIS)

    Spillmann, Adrian; Sonnenfeld, Axel; Rohr, Philipp Rudolf von

    2008-01-01

    The surface of lactose particles was modified by a plasma-enhanced chemical vapor deposition process to improve the flow behavior of the powder. For this, the particulates were treated in a plasma down stream reactor which provides a short (50 ms) and homogeneous exposure to the capacitively coupled RF discharge. The organosilicon monomer hexamethyldisiloxane (HMDSO) was used as a precursor for the formation of SiO x which is deposited on the substrate particle surface. For varying process gas mixtures (O 2 /Ar/HMDSO) and RF power applied, the amount of the deposited material was determined gravimetrically after dissolution of the lactose substrate particles and the chemical composition of the accumulated deposition material was investigated by means of attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy. The concentration of the deposited SiO x relating to the substrate material was found to be in the range of 0.1 wt.%. Based on the ATR-FTIR analysis, the inorganic, i.e. oxidic SiO x fraction of the obtained deposits was shown to be controllable by varying the process parameters, whilst a relatively large amount of organic structures must be considered.

  5. Metabonomics of Pig Blood Plasma Following Whole Body Exposure to Low Levels of Gb Vapor

    National Research Council Canada - National Science Library

    Bevilacqua, Vicky L; D'Onofrio, Terreiice G; Jakubowski, K. M; Hulet, Stanley W; Maguire, Kelly J; Edwards, Jennifer L; Laramee, James A; Brickhouse, Mark D

    2005-01-01

    ...), for which complex data must be analyzed. Therefore, we have begun an exploration of the use of chemometrics for the correlation of metabolic change with low-level CWA exposure in animal models...

  6. Nonlinear behaviors of a bounded electron beam-plasma system

    International Nuclear Information System (INIS)

    Iizuka, Satoru; Saeki, Koichi; Sato, Noriyoshi; Hatta, Yoshisuke

    1985-01-01

    Nonlinear developments of a bounded electron beam-plasma system including stationary electrons are investigated experimentally. A stable double layer is formed as a result of ion trapping in a growing negative potential dip induced by the Pierce instability above the current regime of the Buneman instability. In the in-between regime of the Buneman and Pierce instabilities, energetic ions are observed. This effective ion heating is caused by ion detrapping due to double-layer disruption, being consistent with computer simulation. (author)

  7. Data processing of personnel exposure in TLD and film systems

    International Nuclear Information System (INIS)

    Lerner, A.; Liav, N.; Eisen, Y.

    1979-01-01

    The program for the processing and storage of data on the personnel irradiation exposure in Israel is built on the data base of the Weizmann Institute of Science; it is a general program suitable for both TLD and film dosimetry. The TSO system helped bring up-to-date the data of the various collections in an interactive way. The introduction of the TLD dosemeters in the badge service required certain changes in the thinking line - this because the TLD being a personal dosemeter is returned into service after having been deciphered. This demands following up the dosemeter when the worker moves from unit to unit or after he had finished his work. The program takes into account the internal exposures,too and conforms to the new recommendation published in ICRP-26. (B.G.)

  8. Short-Term Systemic Effects of Nose-Only Cigarette Smoke Exposure in Mice: Role of Oxidative Stress

    Directory of Open Access Journals (Sweden)

    Abderrahim Nemmar

    2013-01-01

    Full Text Available Background/Aims: Long–term cigarette smoking (CS is a major risk factor for respiratory and cardiovascular diseases, and is also known to adversely affect other organs. However, data on the systemic effects of short-term CS exposure (STCSE are scarce. Presently, using a nose-only exposure system, we evaluated the systemic effects of STCSE in mice. Methods: We assessed the effects of CS generated by 9 consecutive cigarettes per day for 4 days in a nose-only exposure system on cardiovascular, hepatic and renal endpoints evaluated on day 5 in mice. Control mice were exposed to air only. Results: CS significantly increased systolic blood pressure and decreased total nitric oxide plasma concentration. Circulating platelets and erythrocyte numbers were also increased. However, STCSE did not significantly increase thrombosis in pial arterioles and venules. STCSE significantly raised plasma alanine aminotransferase and gamma glutamyl transpeptidase activities, but did not affect urea or creatinine concentrations. Interestingly, while STCSE enhanced the production of reactive oxygen species in heart and kidney and lipid peroxidation in heart, liver and kidneys, it also enhanced the antioxidant activity of superoxide dismutase, probably indicating that STCSE causes adaptive reactions to counterbalance the potentially damaging action of oxygen radicals induced by STCSE. Conclusion: These results suggest that STCSE causes blood pressure increase, hepatotoxicity and oxidative stress in the heart, liver and the kidneys. These data provide information on the initial steps leading to the systemic effects of STCSE, a stage at which the diseases may likely be reversed.

  9. Simulated Irradiation of Samples in HFIR for use as Possible Test Materials in the MPEX (Material Plasma Exposure Experiment) Facility

    Energy Technology Data Exchange (ETDEWEB)

    Ellis, Ronald James [ORNL; Rapp, Juergen [ORNL

    2014-01-01

    The importance of Plasma Material Interaction (PMI) is a major concern in fusion reactor design and analysis. The Material-Plasma Exposure eXperiment (MPEX) facility will explore PMI under fusion reactor plasma conditions. Samples with accumulated displacements per atom (DPA) damage produced by irradiations in the High Flux Isotope Reactor (HFIR) at Oak Ridge National Laboratory (ORNL) will be studied in the MPEX facility. The project presented in this paper involved performing assessments of the induced radioactivity and resulting radiation fields of a variety of potential fusion reactor materials. The scientific code packages MCNP and SCALE were used to simulate irradiation of the samples in HFIR; generation and depletion of nuclides in the material and the subsequent composition, activity levels, gamma radiation fields, and resultant dose rates as a function of cooling time. These state-of-the-art simulation methods were used in addressing the challenge of the MPEX project to minimize the radioactive inventory in the preparation of the samples for inclusion in the MPEX facility.

  10. Integration of atomic layer deposited high-k dielectrics on GaSb via hydrogen plasma exposure

    Directory of Open Access Journals (Sweden)

    Laura B. Ruppalt

    2014-12-01

    Full Text Available In this letter we report the efficacy of a hydrogen plasma pretreatment for integrating atomic layer deposited (ALD high-k dielectric stacks with device-quality p-type GaSb(001 epitaxial layers. Molecular beam eptiaxy-grown GaSb surfaces were subjected to a 30 minute H2/Ar plasma treatment and subsequently removed to air. High-k HfO2 and Al2O3/HfO2 bilayer insulating films were then deposited via ALD and samples were processed into standard metal-oxide-semiconductor (MOS capacitors. The quality of the semiconductor/dielectric interface was probed by current-voltage and variable-frequency admittance measurements. Measurement results indicate that the H2-plamsa pretreatment leads to a low density of interface states nearly independent of the deposited dielectric material, suggesting that pre-deposition H2-plasma exposure, coupled with ALD of high-k dielectrics, may provide an effective means for achieving high-quality GaSb MOS structures for advanced Sb-based digital and analog electronics.

  11. Tunable molten oxide pool assisted plasma-melter vitrification systems

    Science.gov (United States)

    Titus, Charles H.; Cohn, Daniel R.; Surma, Jeffrey E.

    1998-01-01

    The present invention provides tunable waste conversion systems and apparatus which have the advantage of highly robust operation and which provide complete or substantially complete conversion of a wide range of waste streams into useful gas and a stable, nonleachable solid product at a single location with greatly reduced air pollution to meet air quality standards. The systems provide the capability for highly efficient conversion of waste into high quality combustible gas and for high efficiency conversion of the gas into electricity by utilizing a high efficiency gas turbine or an internal combustion engine. The solid product can be suitable for various commercial applications. Alternatively, the solid product stream, which is a safe, stable material, may be disposed of without special considerations as hazardous material. In the preferred embodiment, the arc plasma furnace and joule heated melter are formed as a fully integrated unit with a common melt pool having circuit arrangements for the simultaneous independently controllable operation of both the arc plasma and the joule heated portions of the unit without interference with one another. The preferred configuration of this embodiment of the invention utilizes two arc plasma electrodes with an elongated chamber for the molten pool such that the molten pool is capable of providing conducting paths between electrodes. The apparatus may additionally be employed with reduced use or without further use of the gases generated by the conversion process. The apparatus may be employed as a net energy or net electricity producing unit where use of an auxiliary fuel provides the required level of electricity production. Methods and apparatus for converting metals, non-glass forming waste streams and low-ash producing inorganics into a useful gas are also provided. The methods and apparatus for such conversion include the use of a molten oxide pool having predetermined electrical, thermal and physical

  12. Automatic exposure system for radioactive source at teaching laboratory

    International Nuclear Information System (INIS)

    Seren, Maria Emilia G.; Gaal, Vladmir; Morais, Sergio Luiz de; Rodrigues, Varlei

    2013-01-01

    The development of Compton Scattering experiment, studied by undergraduate students of the Medical Physics course at the Universidade Estadual de Campinas (UNICAMP), takes place in the Medical Physics Teaching Laboratory, belonging to the Gleb Wataghin Physics Institute (IFGW/UNICAMP). The experiment consists of a fixed 137 Cs radioactive source, with current activity of 610.5 MBq and a scintillation detector that turns around the center of the system whose function is to detect the scattered photons spectrum by a scatter object (target). The 137 Cs source is stored in a lead shield with a collimating window for the gamma radiation emitted with energy of 0.662 MeV. This source is exposed only when an attenuation barrier protecting the collimating window is opened. The process of opening and closing the attenuation barrier may deliver a radiation dose to users when done manually. Considering the stochastic harmful effects of ionizing radiation, the goal of this project was to develop an automatic exposure system of the radioactive source, in order to reduce the radiation dose received during the Compton Scattering experiment. The developed system is micro controlled and performs standard operating routines, responding to emergencies. Furthermore, an electromagnetic lock enables quick closing of the barrier by gravity, in case of interruption of the electrical current circuit. Besides reducing the total dose to lab users, the system adds more security to the routine, since it limits the access to the radioactive source and prevents accidental exposure. (author)

  13. Radiation exposure with the NOMAD portable X-ray system.

    Science.gov (United States)

    Goren, A D; Bonvento, M; Biernacki, J; Colosi, D C

    2008-02-01

    A new hand-held battery-operated portable X-ray system was tested for possible leakage radiation through the existing heavy metal compounds surrounding the X-ray tube, backscatter radiation through the lead-filled acrylic shield attached at the end of the exit tube and patient exposure. Dose measurements were conducted using a DXTRR phantom and a water phantom. All measurements were recorded using calibrated thermoluminescent dosimetry (TLD), calibrated Unfors Model 583L dosemeter, and a calibrated Radcal MDH model 1015 dosemeter. The settings for all exposure were 60 kVp, 2.3 mA and 0.25 s using Kodak Insight (Class F) film. All backscatter measurements, in front of the shield, behind the shield, at the finger of the operator, the operator's chest, eyes and gonads were significantly below the maximum permissible radiation leakage as per the United States Food and Drug Administration regulations (100 mR h(-1)). Our measurements indicate that the exposure would be well within the occupational maximum permissible dose for an occupationally exposed person. Film dose was consistent with the manufacturer's recommendations. As a result of our measurements, the State of New York Bureau of Environmental Radiation Protection granted us a variance to use the NOMAD on a case-by-case basis. Our data have shown that the NOMAD presents risks that are no greater than with standard dental radiographic units to the patient or operator and the measured doses are well below recommended levels.

  14. Plasma driving system requirements for commercial tokamak fusion reactors

    International Nuclear Information System (INIS)

    Brooks, J.N.; Kustom, R.C.; Stacey, W.M. Jr.

    1978-01-01

    The plasma driving system for a tokamak reactor is composed of an ohmic heating (OH) coil, equilibrium field (EF) coil, and their respective power supplies. Conceptual designs of an Experimental Power Reactor (EPR) and scoping studies of a Demonstration Power Reactor have shown that the driving system constitutes a significant part of the overall reactor cost. The capabilities of the driving system also set or help set important parameters of the burn cycle, such as the startup time, and the net power output. Previous detailed studies on driving system dynamics have helped to define the required characteristics for fast-pulsed superconducting magnets, homopolar generators, and very high power (GVA) power supplies for an EPR. This paper summarizes results for a single reactor configuration together with several design concepts for the driving system. Both the reactor configuration and the driving system concepts are natural extensions from the EPR. Thus, the new results presented in this paper can be compared with the previous EPR results to obtain a consistent picture of how the driving system requirements will evolve--for one particular design configuration

  15. Plasma driving system requirements for commercial tokamak fusion reactors

    International Nuclear Information System (INIS)

    Brooks, J.N.; Kustom, R.C.; Stacey, W.M. Jr.

    1977-01-01

    The plasma driving system for a tokamak reactor is composed of an ohmic heating (OH) coil, equilibrium field (EF) coil, and their respective power supplies. Conceptual designs of an Experimental Power Reactor (EPR) and scoping studies of a Demonstration Power Reactor have shown that the driving system constitutes a significant part of the overall reactor cost. The capabilities of the driving system also set or help set important parameters of the burn cycle, such as the startup time, and the net power output. Previous detailed studies on driving system dynamics have helped to define the required characteristics for fast-pulsed superconducting magnets, homopolar generators, and very high power (GVA) power supplies for an EPR. This paper summarizes results for a single reactor configuration together with several design concepts for the driving system. Both the reactor configuration and the driving system concepts are natural extensions from the EPR. Thus, the new results can be compared with the previous EPR results to obtain a consistent picture of how the driving system requirements will evolve--for one particular design configuration

  16. Communication systems and the role of plasma processing

    International Nuclear Information System (INIS)

    Boswell, R.; Love, J.

    2000-01-01

    Full text: The term telecommunications now encompasses telephone and television, bringing information to two of our most developed senses. Traditionally, these systems have been analogue and quite well separated, but the advent of broad-band digital communication systems carried by glass fibres has brought about a fusion of sound and image so that simple telephone calls are mixed in with television and the web. A bunch of pulses is just a bunch of pulses. There is a major push to move all vision and sound to the web, requiring a huge increase in bandwidth. A number of areas in the US, especially in the Bay area of California where Silicon Valley and the dot.comms account for an economy of 34 billion dollars in the first quarter of the new millennium, homes with cable or DSL phone links can expect a data rate about 100 times faster than present modems. In Canberra, a 'roll out' by TRANSACT, a spin off company from ACTElectricityWater, expects to offer video on demand, telephone and television via links to private houses of up to 50MB.s -1 , over 1000 times that of our present system. Around the world the perceived need for band width, driven by 5MB.s -1 necessary for quality video, is increasing dramatically and will continue for the next decade. To achieve such high rates, many wavelengths are used to carry the pulsed information down each fibre in a system called Wavelength Division Multiplexing (WDM) and the multiplexers and demultiplexers are optical circuits fabricated in circular or rectangular waveguides. This is only the first step in the process of optical integration of many optical circuits on the same silicon chip. In this talk I will describe how some of these components are manufactured and how plasma processing is playing a pivotal role in the etching and deposition of the buried optical waveguides. As distinct from micro-electronics where plasma processing is well established and a mature technology, in the manufacture of optical circuits, plasmas

  17. Liquid chromatography tandem mass spectrometry determination of total budesonide levels in dog plasma after inhalation exposure.

    Science.gov (United States)

    Berg, Seija; Melamies, Marika; Rajamäki, Minna; Vainio, Outi; Peltonen, Kimmo

    2012-01-01

    A sensitive and selective method to quantify budesonide in dog plasma samples was developed and fully validated. Liquid-liquid extraction was followed by solid-phase extraction and liquid chromatography-tandem mass spectrometry with electrospray ionization. After reconstitution of the analytes in the mobile phase, samples were analysed by reversed-phase liquid chromatography with isocratic elution. d8-Budesonide was used as an internal standard, and characteristic transitions of d8-budesonide and budesonide were used for quantification. The method was validated with respect to selectivity, specificity, linearity, recovery, repeatability, reproducibility and limits of detection and quantification. The validated method was successfully applied to monitor the plasma levels of budesonide in dogs exposed to clinical doses of inhaled and intravenous drug.

  18. Electromagnetic radiation and nonlinear energy flow in an electron beam-plasma system

    Science.gov (United States)

    Whelan, D. A.; Stenzel, R. L.

    1985-01-01

    It is shown that the unstable electron-plasma waves of a beam-plasma system can generate electromagnetic radiation in a uniform plasma. The generation mechanism is a scattering of the unstable electron plasma waves off ion-acoustic waves, producing electromagnetic waves whose frequency is near the local plasma frequency. The wave vector and frequency matching conditions of the three-wave mode coupling are experimentally verified. The electromagnetic radiation is observed to be polarized with the electric field parallel to the beam direction, and its source region is shown to be localized to the unstable plasma wave region. The frequency spectrum shows negligible intensity near the second harmonic of the plasma frequency. These results suggest that the observed electromagnetic radiation of type III solar bursts may be generated near the local plasma frequency and observed downstream where the wave frequency is near the harmonic of the plasma frequency.

  19. Plasma density remote control system of experimental advanced superconductive tokamak

    International Nuclear Information System (INIS)

    Zhang Mingxin; Luo Jiarong; Li Guiming; Wang Hua; Zhao Dazheng; Xu Congdong

    2007-01-01

    In Tokamak experiments, experimental data and information on the density control are stored in the local computer system. Therefore, the researchers have to be in the control room for getting the data. Plasma Density Remote Control System (DRCS), which is implemented by encapsulating the business logic on the client in the B/S module, conducts the complicated science computation and realizes the synchronization with the experimental process on the client. At the same time, Web Services and Data File Services are deployed for the data exchange. It is proved in the experiments that DRCS not only meets the requirements for the remote control, but also shows an enhanced capability on the data transmission. (authors)

  20. Exact solutions for a system of nonlinear plasma fluid equations

    International Nuclear Information System (INIS)

    Prahovic, M.G.; Hazeltine, R.D.; Morrison, P.J.

    1991-04-01

    A method is presented for constructing exact solutions to a system of nonlinear plasma fluid equations that combines the physics of reduced magnetohydrodynamics and the electrostatic drift-wave description of the Charney-Hasegawa-Mima equation. The system has nonlinearities that take the form of Poisson brackets involving the fluid field variables. The method relies on modifying a class of simple equilibrium solutions, but no approximations are made. A distinguishing feature is that the original nonlinear problem is reduced to the solution of two linear partial differential equations, one fourth-order and the other first-order. The first-order equation has Hamiltonian characteristics and is easily integrated, supplying information about the general structure of solutions. 6 refs

  1. Oxidative modification and electrochemical inactivation of Escherichia coli upon cold atmospheric pressure plasma exposure.

    Directory of Open Access Journals (Sweden)

    Marlène Dezest

    Full Text Available Cold atmospheric pressure plasmas (CAPPs are known to have bactericidal effects but the mechanism of their interaction with microorganisms remains poorly understood. In this study the bacteria Escherichia coli were used as a model and were exposed to CAPPs. Different gas compositions, helium with or without adjunctions of nitrogen or oxygen, were used. Our results indicated that CAPP induced bacterial death at decontamination levels depend on the duration, post-treatment storage and the gas mixture composition used for the treatment. The plasma containing O2 in the feeding gas was the most aggressive and showed faster bactericidal effects. Structural modifications of treated bacteria were observed, especially significant was membrane leakage and morphological changes. Oxidative stress caused by plasma treatment led to significant damage of E. coli. Biochemical analyses of bacterial macromolecules indicated massive intracellular protein oxidation. However, reactive oxygen and nitrogen species (RONS are not the only actors involved in E. coli's death, electrical field and charged particles could play a significant role especially for He-O2 CAPP.

  2. Effect of antenna capacitance on the plasma characteristics of an internal linear inductively coupled plasma system

    International Nuclear Information System (INIS)

    Lim, Jong Hyeuk; Kim, Kyong Nam; Park, Jung Kyun; Yeom, Geun Young

    2008-01-01

    This study examined the effect of the antenna capacitance of an inductively coupled plasma (ICP) source, which was varied using an internal linear antenna, on the electrical and plasma characteristics of the ICP source. The inductive coupling at a given rf current increased with decreasing antenna capacitance. This was caused by a decrease in the inner copper diameter of the antenna made from coaxial copper/quartz tubing, which resulted in a higher plasma density and lower plasma potential. By decreasing the diameter of the copper tube from 25 to 10 mm, the plasma density of a plasma source size of 2750x2350 mm 2 was increased from approximately 8x10 10 /cm 3 to 1.5x10 11 /cm 3 at 15 mTorr Ar and 9 kW of rf power

  3. Pressure-induced shift of the plasma in a helical system with ideally conducting wall

    International Nuclear Information System (INIS)

    Pustovitov, V.D.

    2004-01-01

    The global plasma shift is calculated analytically for a helical system with an ideal wall. The derived expression for the plasma shift, incorporating both the finite-β plasma expansion and the opposing reaction of the nearby ideal wall, can be used for interpreting the observable high-β equilibrium effects in LHD and other helical devices. (author)

  4. REMIT, Radiation Exposure Monitoring and Information Transmittal System

    International Nuclear Information System (INIS)

    Cale, R.; Clark, T.; Dixson, P.; Hagemeyer, D.; Hardwick, C.; Pippen, H.

    1997-01-01

    1 - Description of program or function: The Radiation Exposure Monitoring and Information Transmittal (REMIT) system is designed to assist U.S. Nuclear Regulatory Commission (NRC) licensees in meeting the reporting requirements of the Revised 10 CFR Part 20 and in agreement with the guidance contained in Regulatory Guide 8.7, Rev.1, Instructions for Recording and Reporting Occupational Exposure Data. REMIT is a personal computer (PC) -based menu driven system that facilitates the manipulation of data base files to record and report radiation exposure information. REMIT is designed to be user-friendly and contains the full text of Regulatory Guide 8.7, Rev.1, on-line as well as context-sensitive help throughout the program. The user can enter data directly from NRC Form 5s or Form 4s. REMIT allows the user to view the individual's exposure in relation to regulatory or administrative limits and will alert the user to exposures in excess of these limits. The system also provides for the calculation and summation of dose from intakes and the determination of the dose to the maximally exposed extremity for the monitoring year. REMIT can produce NRC Form 5s and 4s in paper and electronic format and can import/export data from ASCII and data base files. 2 - Method of solution: REMIT makes use of the dose conversion factors from EPA Report 11 Limiting Values of Radionuclide Intake and Air Concentration and Dose Conversion Factors for Inhalation, Submission, and Ingestion, to calculate the Committed Dose Equivalent to the maximally exposed organ and the committed Effective Dose Equivalent from intakes measured in micro-curies. REMIT also estimates the amount (in micrograms) of uranium intake from the activity entered in micro-curies. This calculation is based on the specific activities of the uranium isotopes. 3 - Restrictions on the complexity of the problem: REMIT is a single- user system that only runs on IBM compatible PC systems under DOS and supports only Hewlett

  5. Study of Globus-M Tokamak Poloidal System and Plasma Position Control

    Science.gov (United States)

    Dokuka, V. N.; Korenev, P. S.; Mitrishkin, Yu. V.; Pavlova, E. A.; Patrov, M. I.; Khayrutdinov, R. R.

    2017-12-01

    In order to provide efficient performance of tokamaks with vertically elongated plasma position, control systems for limited and diverted plasma configuration are required. The accuracy, stability, speed of response, and reliability of plasma position control as well as plasma shape and current control depend on the performance of the control system. Therefore, the problem of the development of such systems is an important and actual task in modern tokamaks. In this study, the measured signals from the magnetic loops and Rogowski coils are used to reconstruct the plasma equilibrium, for which linear models in small deviations are constructed. We apply methods of the H∞-optimization theory to the synthesize control system for vertical and horizontal position of plasma capable to working with structural uncertainty of the models of the plant. These systems are applied to the plasma-physical DINA code which is configured for the tokamak Globus-M plasma. The testing of the developed systems applied to the DINA code with Heaviside step functions have revealed the complex dynamics of plasma magnetic configurations. Being close to the bifurcation point in the parameter space of unstable plasma has made it possible to detect an abrupt change in the X-point position from the top to the bottom and vice versa. Development of the methods for reconstruction of plasma magnetic configurations and experience in designing plasma control systems with feedback for tokamaks provided an opportunity to synthesize new digital controllers for plasma vertical and horizontal position stabilization. It also allowed us to test the synthesized digital controllers in the closed loop of the control system with the DINA code as a nonlinear model of plasma.

  6. Visco-instability of shear viscoelastic collisional dusty plasma systems

    Science.gov (United States)

    Mahdavi-Gharavi, M.; Hajisharifi, K.; Mehidan, H.

    2018-04-01

    In this paper, the stability of Newtonian and non-Newtonian viscoelastic collisional shear-velocity dusty plasmas is studied, using the framework of a generalized hydrodynamic (GH) model. Motivated by Banerjee et al.'s work (Banerjee et al., New J. Phys., vol. 12 (12), 2010, p. 123031), employing linear perturbation theory as well as the local approximation method in the inhomogeneous direction, the dispersion relations of the Fourier modes are obtained for Newtonian and non-Newtonian dusty plasma systems in the presence of a dust-neutral friction term. The analysis of the obtained dispersion relation in the non-Newtonian case shows that the inhomogeneous viscosity force depending on the velocity shear profile can be the genesis of a free energy source which leads the shear system to be unstable. Study of the dust-neutral friction effect on the instability of the considered systems using numerical analysis of the dispersion relation in the Newtonian case demonstrates that the maximum growth rate decreases considerably by increasing the collision frequency in the hydrodynamic regime, while this reduction can be neglected in the kinetic regime. Results show a more significant stabilization role of the dust-neutral friction term in the non-Newtonian cases, through decreasing the maximum growth rate at any fixed wavenumber and construction of the instable wavenumber region. The results of the present investigation will greatly contribute to study of the time evolution of viscoelastic laboratory environments with externally applied shear; where in these experiments the dust-neutral friction process can play a considerable role.

  7. Exposure of ventilation system cleaning workers to harmful microbiological agents.

    Science.gov (United States)

    Gołofit-Szymczak, Małgorzata; Ławniczek-Wałczyk, Anna; Górny, Rafał L

    2013-01-01

    Regular inspection of the cleanliness of the ventilation systems, as well as their periodic cleaning and disinfection, if necessary, are the main factors of the proper maintenance of each system. Performing maintenance operations on the ventilation system, workers are exposed to risk associated with the exposure to harmful biological agents. The aim of this study was to assess the employees' exposure to bioaerosols during maintenance work on ventilation systems. Bioaerosol measurements were carried out using a button sampler. The microbial particles were collected on gelatin filters. Settled-dust samples from the inner surface of the air ducts and filter-mat samples were selected for the microbiological analysis. In the collected air, dust and filter samples the concentration of bacteria and fungi were determined. Bacteria and fungi concentrations ranged between 3.6 x 10(2)-2.2 x 10(4) CFU/m3 and 4.7 x 10(2)-4.5 x 10(3) CFU/m3 at workplaces where the operations connected with mechanical ventilation cleaning were performed and 2.2 x 10(4)-1.2 x 10(5) CFU/m2 and 9.8 x 10(1)-2.5 x 10(2) CFU/m3 at workplaces where filter exchange was performed, respectively. The qualitative analysis of microorganisms isolated from the air in all studied workplaces revealed that the most prevalent bacteria belonged to Bacillus genus. The average concentrations of bacteria and fungi in filter-mat samples were 3.3 x 10(3) CFU/cm2 and 1.4 x 10(4) CFU/cm2, respectively. In settled-dust samples, average concentrations were 591 CFU/100 cm2 and 52 CFU/100 cm2, for bacteria and fungi respectively. Workers cleaning ventilation systems are exposed to harmful biological agents classified into risk groups, 1 and 2, according to their level of the risk of infection. The research conducted in the workplace can be the basis of risk assessment related to exposure to harmful biological agents during maintenance work in ventilation.

  8. Studies on performances of the control system of plasma position and shape

    International Nuclear Information System (INIS)

    Aikawa, Hiroshi; Tsuzuki, Naohisa; Kimura, Toyoaki; Ogata, Atsushi; Ninomiya, Hiromasa

    1978-09-01

    Performance in the control system of plasma position and shape is determined by estimating the disturbing field, system functions and load variation of the controlled object. Various stray fields are considered as disturbing field. Plasma internal inductance and poloidal beta are taken into consideration as load variation of the controlled object. The required performance is obtained through considerations of plasma equilibrium, stability, impurity concentration and sensors accuracy. The results are described as requests to the poloidal power supply system. (author)

  9. Hematocrit and plasma osmolality values of young-of-year shortnose sturgeon following acute exposures to combinations of salinity and temperature

    Science.gov (United States)

    Ziegeweid, J.R.; Black, M.C.

    2010-01-01

    Little is known about the physiological capabilities of young-of-year (YOY) shortnose sturgeon. In this study, plasma osmolality and hematocrit values were measured for YOY shortnose sturgeon following 48-h exposures to 12 different combinations of salinity and temperature. Hematocrit levels varied significantly with temperature and age, and plasma osmolalities varied significantly with salinity and age. Plasma osmolality and hematocrit values were similar to previously published values for other sturgeons of similar age and size in similar treatment conditions. ?? 2010 Springer Science+Business Media B.V.

  10. Human systemic exposure to [¹⁴C]-paraphenylenediamine-containing oxidative hair dyes: Absorption, kinetics, metabolism, excretion and safety assessment.

    Science.gov (United States)

    Nohynek, Gerhard J; Skare, Julie A; Meuling, Wim J A; Wehmeyer, Kenneth R; de Bie, Albertus Th H J; Vaes, Wouter H J; Dufour, Eric K; Fautz, Rolf; Steiling, Winfried; Bramante, Mario; Toutain, Herve

    2015-07-01

    Systemic exposure was measured in humans after hair dyeing with oxidative hair dyes containing 2.0% (A) or 1.0% (B) [(14)C]-p-phenylenediamine (PPD). Hair was dyed, rinsed, dried, clipped and shaved; blood and urine samples were collected for 48 hours after application. [(14)C] was measured in all materials, rinsing water, hair, plasma, urine and skin strips. Plasma and urine were also analysed by HLPC/MS/MS for PPD and its metabolites (B). Total mean recovery of radioactivity was 94.30% (A) or 96.21% (B). Mean plasma Cmax values were 132.6 or 97.4 ng [(14)C]-PPDeq/mL, mean AUC(0-∞) values 1415 or 966 ng [(14)C]-PPDeq/mL*hr in studies A or B, respectively. Urinary excretion of [(14)C] mainly occurred within 24 hrs after hair colouring with a total excretion of 0.72 or 0.88% of applied radioactivity in studies A or B, respectively. Only N,N'-diacetylated-PPD was detected in plasma and the urine. A TK-based human safety assessment estimated margins of safety of 23.3- or 65-fold relative to respective plasma AUC or Cmax values in rats at the NOAEL of a toxicity study. Overall, hair dyes containing PPD are unlikely to pose a health risk since they are used intermittently and systemic exposure is limited to the detoxified metabolite N,N'-diacetyl-PPD. Copyright © 2015 Elsevier Ltd. All rights reserved.

  11. Effects of lead exposure on oxidative stress biomarkers and plasma biochemistry in waterbirds in the field.

    Science.gov (United States)

    Martinez-Haro, Monica; Green, Andy J; Mateo, Rafael

    2011-05-01

    Medina lagoon in Andalusia has one of the highest densities of spent lead (Pb) shot in Europe. Blood samples from waterbirds were collected in 2006-2008 to measure Pb concentration (PbB), δ-aminolevulinic acid dehydratase (ALAD), oxidative stress biomarkers and plasma biochemistry. PbB above background levels (>20 μg/dl) was observed in 19% (n=59) of mallards (Anas platyrhynchos) and in all common pochards (Aythya ferina) (n=4), but common coots (Fulica atra) (n=37) and moorhens (Gallinula chloropus) (n=12) were all 6 μg/dl. In mallards, an inhibition of glutathione peroxidase (GPx) and an increased level of oxidized glutathione (oxGSH) in red blood cells (RBC) were associated with PbB levels >20 μg/dl. In coots, PbB levels were negatively related to vitamin A and carotenoid levels in plasma, and total glutathione in RBCs; and positively related with higher superoxide dismutase and GPx activities and % oxGSH in RBCs. Overall, the results indicate that previously assumed background levels of PbB for birds need to be revised. Copyright © 2011 Elsevier Inc. All rights reserved.

  12. Degradation of Albumin on Plasma-Treated Polystyrene by Soft X-ray Exposure

    Directory of Open Access Journals (Sweden)

    Nina Recek

    2016-06-01

    Full Text Available Thin films of human serum albumin (HSA were immobilized on polystyrene (PS substrates previously functionalized either with polar or nonpolar functional groups. The functionalization was performed by treatment with cold gaseous plasma created in pure oxygen and tetrafluoromethane (CF4 plasmas, respectively. Samples were examined with soft X-rays in the photon energy range of 520 to 710 eV in the ANTARES beam line at SOLEIL Synchrotron. NEXAFS spectra of O K-edge and F K-edge were collected at different spots of the sample, and measurements at each spot were repeated many times. A strong degradation of the HSA protein was observed. The weakly irradiated samples exhibited strong absorption at 531.5 eV associated with the O 1s→π*amide transitions, and a broad non distinctive peak at 540 eV was attributed to the O 1s→σ*C–O transitions. Both peaks decreased with increasing irradiation time until they were completely replaced by a broad non-distinctive peak at around 532 eV, indicating the destruction of the original protein conformation. The shortage of the amide groups indicated breakage of the peptide bonds.

  13. Blood plasma levels of anterior pituitary hormones of rabbits after apricot seed exposure in vivo

    Directory of Open Access Journals (Sweden)

    Katarína MICHALCOVÁ

    2016-12-01

    Full Text Available The present study describes possible changes in plasma levels of anterior pituitary hormones induced by bitter apricot (Prunus armeniaca L. seeds in young female rabbits in vivo. Prunus armeniaca L. is an important medicinal edible plant species commonly known as “apricot”. The apricot is a member of the Rosaceae and subfamily Prunoideae. It is one of the most delicious and commercially traded fruits in the world. Apricot kernel is the inner part of the seed of the apricot fruit. The kernel is used to produce oil and other chemicals used for medicinal purposes. The seeds are potentially useful in human nutrition and for treatment several diseases especially cancer. In the present study apricot seeds were mixed with feed at different doses 0, 60, 300, 420 mg*kg-1 of body weight. ELISA was used to determine the levels of follicle stimulating hormone (FSH, luteinizing hormone (LH and prolactin (PRL. 58-days application of apricot seeds did not affect the concentration (P≥0.05 of PRL, LH in blood plasma. Significant (P≤0.01 inhibition of FSH levels induced by the seeds was found at the dose of 420 mg*kg-1 but not at 60 and 300 mg*kg-1 of body weight. These results are suggesting that the natural substances present in apricot seeds may be involved in mechanisms of ovarian folliculogenesis.

  14. A Study on Pharmacokinetics of Bosentan with Systems Modeling, Part 2: Prospectively Predicting Systemic and Liver Exposure in Healthy Subjects.

    Science.gov (United States)

    Li, Rui; Kimoto, Emi; Niosi, Mark; Tess, David A; Lin, Jian; Tremaine, Larry M; Di, Li

    2018-04-01

    Predicting human pharmacokinetics of novel compounds is a critical step in drug discovery and clinical study design but continues to be a challenging task for hepatic transporter substrates, particularly in predicting their liver exposures. In this study, using bosentan as an example, we prospectively predicted systemic exposure and the (pseudo) steady-state unbound liver-to-unbound plasma ratio ( K p uu ) in healthy subjects using 1) a mechanistic approach solely based on in vitro hepatocyte assays and 2) an approach based on hepatic process rates from monkey in vivo data but Michaelis-Menten constants from in vitro data. Both methods reasonably match the observed human systemic time course data, but the second method leads to better prediction accuracy. In addition, the second method can predict a human K p uu value that is close to the value deduced using clinical data. We also generated rat and monkey liver K p uu values in terminal studies. However, these directly measured animal values are different from the deduced human value. Copyright © 2018 by The American Society for Pharmacology and Experimental Therapeutics.

  15. Ultrastructural, Confocal and Viscoelastic Characteristics of Whole Blood and Plasma After Exposure to Cadmium and Chromium Alone and in Combination: An Ex Vivo Study

    Directory of Open Access Journals (Sweden)

    Chantelle Venter

    2017-10-01

    Full Text Available Background/Aims: Heavy metal pollution is increasing in the environment, contaminating water, food and air supplies. This can be linked to many anthropogenic activities. Heavy metals are absorbed through the skin, inhalation and/or orally. Irrespective of the manner of heavy metal entry in the body, the blood circulatory system is potentially the first to be affected following exposure and adverse effects on blood coagulation can lead to associated thrombotic disease. Although the plasma levels and the effects of cadmium (Cd and chromium (Cr on erythrocytes and lymphocytes have been described, the environmental exposure to heavy metals are not limited to a single metal and often involves metal mixtures, with each metal having different rates of absorption, different cellular, tissue, and organ targets. Therefore the aim of this study is to investigate the effects of the heavy metals Cd and Cr alone and whether Cr synergistically increases the effect of Cd on physiological important processes such as blood coagulation. Methods: Human blood was exposed to the heavy metals ex vivo, and thereafter morphological analysis was performed with scanning electron- and confocal laser scanning microscopy (CLSM in conjunction with thromboelastography®. Results: The erythrocytes, platelets and fibrin networks presented with ultrastructural changes, including varied erythrocytes morphologies, activated platelets and significantly thicker fibrin fibres in the metal-exposed groups. CLSM analysis revealed the presence of phosphatidylserine on the outer surface of the membranes of the spherocytic erythrocytes exposed to Cd and Cr alone and in combination. The viscoelastic analysis revealed only a trend that indicates that clots that will form after heavy metal exposure, will likely be fragile and unstable especially for Cd and Cr in combination. Conclusion: This study identified the blood as an important target system of Cd and Cr toxicity.

  16. Analytical calculations of the rotational transform angles in the torsatron systems with different plasma pressure profiles

    International Nuclear Information System (INIS)

    Kuznetsov, Yu.K.; Pinos, I.B.; Tyupa, V.I.

    1999-01-01

    With formulas for averaging over magnetic surfaces general analytical expressions are here deduced to determine the rotational transform angles in stellarator systems having different plasma pressure profiles

  17. Technological plasma source equipped with combined system of vacuum-arc discharge initiation

    International Nuclear Information System (INIS)

    Sysoev, Yu.O.

    2013-01-01

    The construction and the operation principle of erosion plasma source with a three-stage system of vacuum-arc discharge excitation is described. As first two step was used the modified contactless start system with plasma injector, which was widely used in standard plasma sources of the ''Bulat'' systems. The operation principle of the third stage was based on the transition of glow discharge to arc discharge. Coordinated operation of three stages during various stages of coating deposition provided significant increasing of service life and reliability of the system of vacuum-arc discharge initiation and extended the functionality of the plasma source

  18. Multi-probe ionization chamber system for nuclear-generated plasma diagnostics

    International Nuclear Information System (INIS)

    Choi, W.Y.; Ellis, W.H.

    1990-01-01

    This paper reports on the pulsed ionization chamber (PIC) plasma diagnostic system used in studies of nuclear seeded plasma kinetics upgraded to increase the capabilities and extend the range of plasma parameter measurements to higher densities and temperatures. The PIC plasma diagnostic chamber has been provided with additional measurement features in the form of conductivity and Langmuir probes, while the overall experimental system has been fully automated, with computerized control, measurement, data acquisition and analysis by means of IEEE-488 (GPIB) bus control and data transfer protocols using a Macintosh series microcomputer. The design and use of a simple TTL switching system enables remote switching among the various GPIB instruments comprising the multi-probe plasma diagnostic system using software, without the need for a microprocessor. The new system will be used to extend the present study of nuclear generated plasma in He, Ar, Xe, fissionable UF 6 and other fluorine containing gases

  19. Thermal Fatigue Behavior of Air-Plasma Sprayed Thermal Barrier Coating with Bond Coat Species in Cyclic Thermal Exposure

    Directory of Open Access Journals (Sweden)

    Ungyu Paik

    2013-08-01

    Full Text Available The effects of the bond coat species on the delamination or fracture behavior in thermal barrier coatings (TBCs was investigated using the yclic thermal fatigue and thermal-shock tests. The interface microstructures of each TBC showed a good condition without cracking or delamination after flame thermal fatigue (FTF for 1429 cycles. The TBC with the bond coat prepared by the air-plasma spray (APS method showed a good condition at the interface between the top and bond coats after cyclic furnace thermal fatigue (CFTF for 1429 cycles, whereas the TBCs with the bond coats prepared by the high-velocity oxygen fuel (HVOF and low-pressure plasma spray (LPPS methods showed a partial cracking (and/or delamination and a delamination after 780 cycles, respectively. The TBCs with the bond coats prepared by the APS, HVOF and LPPS methods were fully delaminated (>50% after 159, 36, and 46 cycles, respectively, during the thermal-shock tests. The TGO thickness in the TBCs was strongly dependent on the both exposure time and temperature difference tested. The hardness values were found to be increased only after the CFTF, and the TBC with the bond coat prepared by the APS showed the highest adhesive strength before and after the FTF.

  20. Mobilisation of heavy metals into the urine by CaEDTA: relation to erythrocyte and plasma concentrations and exposure indicators.

    Science.gov (United States)

    Araki, S; Aono, H; Murata, K

    1986-09-01

    To investigate the effects of calcium disodium ethylenediamine tetra-acetate (CaEDTA) on the urinary excretion, erythrocyte, and plasma concentrations and exposure indicators of seven heavy metals, CaEDTA was administered by intravenous infusion to 20 workers exposed to lead, zinc, and copper. The workers' blood lead concentrations ranged from 22 to 59 micrograms/dl (mean 38 micrograms/dl (1.8 mumol/l]. The 24 hour urinary excretion of metals after CaEDTA administration (mobilisation yield) was on average 13 times the background excretion for lead, 11 times for zinc, 3.8 times for manganese, 3.4 times for cadmium, 1.3 times for copper, and 1.1 times for chromium; no significant increase was found for mercury. The mobilisation yield of lead (MPb) was significantly correlated with whole blood and erythrocyte concentrations and the urinary excretion of lead but not with its plasma concentration; similarly, the mobilisation yield of cadmium was significantly correlated with its erythrocyte concentration. In addition, MPb was significantly correlated with intra-erythrocytic enzyme delta-aminolaevulinic acid dehydratase activity and urinary coproporphyrin excretion. The relation between the mobilisation yield of heavy metals and their body burden (and toxic signs) is discussed in the light of these findings.

  1. Childhood exposure to ambient polycyclic aromatic hydrocarbons is linked to epigenetic modifications and impaired systemic immunity in T cells

    Science.gov (United States)

    Hew, K. M.; Walker, A. I.; Kohli, A.; Garcia, M.; Syed, A.; McDonald-Hyman, C.; Noth, E. M.; Mann, J. K.; Pratt, B.; Balmes, J.; Hammond, S. Katharine; Eisen, E. A.; Nadeau, K. C.

    2015-01-01

    Summary Background Evidence suggests that exposure to polycyclic aromatic hydrocarbons (PAHs) increases atopy; it is unclear how PAH exposure is linked to increased severity of atopic diseases. Objective We hypothesized that ambient PAH exposure is linked to impairment of immunity in atopic children (defined as children with asthma and/or allergic rhinitis) from Fresno, California, an area with elevated ambient PAHs. Methods We recruited 256 subjects from Fresno, CA. Ambient PAH concentrations (ng/m3) were measured using a spatial-temporal regression model over multiple time periods. Asthma diagnosis was determined by current NHLBI criteria. Phenotyping and functional immune measurements were performed from isolated cells. For epigenetic measurements, DNA was isolated and pyrosequenced. Results We show that higher average PAH exposure was significantly associated with impaired Treg function and increased methylation in the forkhead box protein 3 (FOXP3) locus (P < 0.05), conditional on atopic status. These epigenetic modifications were significantly linked to differential protein expression of FOXP3 (P < 0.001). Methylation was associated with cellular functional changes, specifically Treg dysfunction, and an increase in total plasma IgE levels. Protein expression of IL-10 decreased and IFN-γ increased as the extent of PAH exposure increased. The strength of the associations generally increased as the time window for average PAH exposure increased from 24 hr to 1 year, suggesting more of a chronic response. Significant associations with chronic PAH exposure and immune outcomes were also observed in subjects with allergic rhinitis. Conclusions and Clinical Relevance Collectively, these results demonstrate that increased ambient PAH exposure is associated with impaired systemic immunity and epigenetic modifications in a key locus involved in atopy: FOXP3, with a higher impact on atopic children. The results suggest that increased atopic clinical symptoms in children

  2. Intelligent plasma operation and control system for HL-2M

    International Nuclear Information System (INIS)

    Xia, F.; Chen, L.Y.; Wang, C.; Zhang, G.; Song, X.M.; Song, X.; Pan, L.; Zhao, L.; Pan, W.; Lan, J.T.

    2015-01-01

    Full text of publication follows. The Intelligent Plasma Operation and Control System (IPOCS) for HL-2M is under construction based on the current actual situation of HL-2A control system in SWIP. The purpose of IPOCS is to replace the routine processes before, during and post discharge with the automatic process algorithms and give various information, for example, status, warning, reason, instruction, suggestion, physics phenomenon etc. to staff who can access the intranet. In this case, the core research objectives can be focused on and the related operations can be carried out referring to the information. The ultimate goal of IPOCS is to improve the efficiency of plant operation and control and physics research for HL-2M and for the fusion reactor in the future. There are three layers in IPOCS, which are named the information collection layer, the data processing layer and the presentation layer respectively. Information collection layer consists of data acquisition system, EPICS system, Audio and Video system, discharge scheduling system, data storage system etc. All raw data are collected and stored in this layer. The data processing layer is the core of IPOCS. Most algorithms are executed here. The basic computation platform is based on cluster (56 cores at present) and Parallel Computing Toolbox provided by Matlab. The physics database for SWIP based on HDF5 and offline EFIT also locate at this layer. All the operations can be finished during the time interval between two shots. The last layer is to present the information from the former two layers. The typical hardware including the large display screen system in the control room, the voice broadcasting system, personal monitors and smart phones, etc.. Several applications has being developed such as Control System Studio (CSS) in SWIP version, WebOPI, Automatic Alarm Display system and so on. IPOCS for HL-2M is at the very beginning phase at present. With more and more systems and algorithms got

  3. Evaluation of automatic exposure control systems in computed tomography

    Energy Technology Data Exchange (ETDEWEB)

    Reina, Thamiris Rosado

    2014-07-01

    The development of the computed tomography (CT) technology has brought wider possibilities on diagnostic medicine. It is a non-invasive method to see the human body in details. As the CT application increases, it raises the concern about patient dose, because the higher dose levels imparted compared to other diagnostic imaging modalities. The radiology community (radiologists, medical physicists and manufacturer) are working together to find the lowest dose level possible, without compromising the diagnostic image quality. The greatest and relatively new advance to lower the patient dose is the automatic exposure control (AEC) systems in CT. These systems are designed to ponder the dose distribution along the patient scanning and between patients taking into account their sizes and irradiated tissue densities. Based on the CT scanning geometry, the AEC-systems are very complex and their functioning is yet not fully understood. This work aims to evaluate the clinical performance of AEC-systems and their susceptibilities to assist on possible patient dose optimizations. The approach to evaluate the AEC-systems of three of the leading CT manufacturers in Brazil, General Electric, Philips and Toshiba, was the extraction of tube current modulation data from the DICOM standard image sequences, measurement and analysis of the image noise of those image sequences and measurement of the dose distribution along the scan length on the surface and inside of two different phantoms configurations. The tube current modulation of each CT scanner associated to the resulted image quality provides the performance of the AECsystem. The dose distribution measurements provide the dose profile due to the tube current modulation. Dose measurements with the AEC-system ON and OFF were made to quantify the impact of these systems regarding patient dose. The results attained give rise to optimizations on the AEC-systems applications and, by consequence, decreases the patient dose without

  4. Evaluation of automatic exposure control systems in computed tomography

    International Nuclear Information System (INIS)

    Reina, Thamiris Rosado

    2014-01-01

    The development of the computed tomography (CT) technology has brought wider possibilities on diagnostic medicine. It is a non-invasive method to see the human body in details. As the CT application increases, it raises the concern about patient dose, because the higher dose levels imparted compared to other diagnostic imaging modalities. The radiology community (radiologists, medical physicists and manufacturer) are working together to find the lowest dose level possible, without compromising the diagnostic image quality. The greatest and relatively new advance to lower the patient dose is the automatic exposure control (AEC) systems in CT. These systems are designed to ponder the dose distribution along the patient scanning and between patients taking into account their sizes and irradiated tissue densities. Based on the CT scanning geometry, the AEC-systems are very complex and their functioning is yet not fully understood. This work aims to evaluate the clinical performance of AEC-systems and their susceptibilities to assist on possible patient dose optimizations. The approach to evaluate the AEC-systems of three of the leading CT manufacturers in Brazil, General Electric, Philips and Toshiba, was the extraction of tube current modulation data from the DICOM standard image sequences, measurement and analysis of the image noise of those image sequences and measurement of the dose distribution along the scan length on the surface and inside of two different phantoms configurations. The tube current modulation of each CT scanner associated to the resulted image quality provides the performance of the AECsystem. The dose distribution measurements provide the dose profile due to the tube current modulation. Dose measurements with the AEC-system ON and OFF were made to quantify the impact of these systems regarding patient dose. The results attained give rise to optimizations on the AEC-systems applications and, by consequence, decreases the patient dose without

  5. Fusion, space and solar plasmas as complex systems

    International Nuclear Information System (INIS)

    Dendy, R O; Chapman, S C; Paczuski, M

    2007-01-01

    Complex systems science seeks to identify simple universal models that capture the key physics of extended macroscopic systems, whose behaviour is governed by multiple nonlinear coupled processes that operate across a wide range of spatiotemporal scales. In such systems, it is often the case that energy release occurs intermittently, in bursty events, and the phenomenology can exhibit scaling, that is a significant degree of self-similarity. Within plasma physics, such systems include Earth's magnetosphere, the solar corona and toroidal magnetic confinement experiments. Guided by broad understanding of the dominant plasma processes-for example, turbulent transport in tokamaks or reconnection in some space and solar contexts-one may construct minimalist complex systems models that yield relevant global behaviour. Examples considered here include the sandpile approach to tokamaks and the magnetosphere and a multiple loops model for the solar coronal magnetic carpet. Such models can address questions that are inaccessible to analytical treatment and are too demanding for contemporary computational resources; thus they potentially yield new insights, but risk being simplistic. Central to the utility of these models is their capacity to replicate distinctive aspects of observed global phenomenology, often strongly nonlinear, or of event statistics, for which no explanation can be obtained from first principles considerations such as the underlying equations. For example, a sandpile model, which embodies critical-gradient-triggered avalanching transport associated with nearest-neighbour mode coupling and simple boundary conditions (and little else), can be used to generate some of the distinctive observed elements of tokamak confinement phenomenology such as ELMing and edge pedestals. The same sandpile model can also generate distributions of energy-release events whose distinctive statistics resemble those observed in the auroral zone. Similarly, a multiple loops model

  6. Modification of adhered dust on plasma-facing surfaces due to exposure to ELMy H-mode plasma in DIII-D

    Directory of Open Access Journals (Sweden)

    I. Bykov

    2017-08-01

    Full Text Available Transient heat load tests have been conducted in the lower divertor of DIII-D using DiMES manipulator in order to study the behavior of dust on tungsten Plasma Facing Components (PFCs during ELMy H-mode discharges. Samples with pre-adhered, pre-characterized dust have been exposed at the outer strike point (OSP in a series of discharges with varied intra-(inter- ELM heat fluxes. We used C dust because of its high sublimation temperature and non-metal properties. Al dust as a surrogate for Be and W dust were employed as relevant to that in the ITER divertor. The poor initial thermal contact between the substrate and the particles led to overheating, sublimation and shrinking of the carbon dust, and wetting induced coagulation of Al dust. Little modification of the W dust was observed. An enhanced surface adhesion and improvement of the thermal contact of C and Al dust were the result of exposure. A post mortem “adhesive tape” sampling showed that 70% of Al, <5% of W and C particles could not be removed from the surface owing to the improved adhesion. Al and C but not W particles that could be lifted had W inclusions indicating damage to the substrate. This suggests that non destructive methods may be inefficient for removal of dust in ITER.

  7. Rotating machinery surveillance system reduces plant downtime and radiation exposure

    International Nuclear Information System (INIS)

    Bohanick, J.S.; Robinson, J.C.; Allen, J.W.

    1988-01-01

    A rotating machinery surveillance system (RMSS) was permanently installed at Grand Gulf nuclear station (GGNS) as part of a program sponsored by the US Department of Energy whose goal was to reduce radiation exposure to power plant personnel resulting from the inspection, maintenance, and repair of rotating machinery. The RMSS was installed at GGNS in 1983 to continuously monitor 173 analog vibration signals from proximity probes mounted on 26 machine trains and ∼450 process data points via a computer data link. Vibration frequency spectra, i.e., the vibration amplitude versus frequency of vibration, and various characterizations of these spectra are the fundamental data collected by the RMSS for performing machinery diagnostics. The RMSS collects vibration frequency spectra on a daily basis for all the monitored rotating equipment and automatically stores the collected spectra for review by the vibration engineer. Vibration spectra automatically stored by the RMSS fall into categories that include the last normal, alarm, minimum and maximum, past three-day data set, baseline, current, and user-saved spectra. During first and second fuel-cycle operation at GGNS, several significant vibration problems were detected by the RMSS. Two of these are presented in this paper: recirculation pumps and turbine-generator bearing degradation. The total reduction in personnel radiation exposure at GGNS from 1985 to 1987 due to the presence of the RMSS was estimated to be in the range from 49 to 54 person-rem

  8. Mercury exposure associated with altered plasma thyroid hormones in the declining western pond turtle (Emys marmorata) from California mountain streams

    Science.gov (United States)

    Meyer, Erik; Eagles-Smith, Collin A.; Sparling, Donald; Blumenshine, Steve

    2014-01-01

    Mercury (Hg) is a global threat to wildlife health that can impair many physiological processes. Mercury has well-documented endocrine activity; however, little work on the effects of Hg on the thyroid hormones triiodothyronine (T3) and thyroxine (T4) in aquatic wildlife exists despite the fact that it is a sensitive endpoint of contaminant exposure. An emerging body of evidence points to the toxicological susceptibility of aquatic reptiles to Hg exposure. We examined the endocrine disrupting potential of Hg in the western pond turtle (Emys marmorata), a long-lived reptile that is in decline throughout California and the Pacific Northwest. We measured total Hg (THg) concentrations in red blood cells (RBCs) and plasma T3 and T4 of turtles from several locations in California that have been impacted by historic gold mining. Across all turtles from all sites, the geometric mean and standard error THg concentration was 0.805 ± 0.025 μg/g dry weight. Sampling region and mass were the strongest determinants of RBC THg. Relationships between RBC THg and T3 and T4 were consistent with Hg-induced disruption of T4 deiodination, a mechanism of toxicity that may cause excess T4 levels and depressed concentrations of biologically active T3.

  9. Mercury exposure associated with altered plasma thyroid hormones in the declining western pond turtle (Emys marmorata) from California mountain streams.

    Science.gov (United States)

    Meyer, Erik; Eagles-Smith, Collin A; Sparling, Donald; Blumenshine, Steve

    2014-01-01

    Mercury (Hg) is a global threat to wildlife health that can impair many physiological processes. Mercury has well-documented endocrine activity; however, little work on the effects of Hg on the thyroid hormones triiodothyronine (T3) and thyroxine (T4) in aquatic wildlife exists despite the fact that it is a sensitive endpoint of contaminant exposure. An emerging body of evidence points to the toxicological susceptibility of aquatic reptiles to Hg exposure. We examined the endocrine disrupting potential of Hg in the western pond turtle (Emys marmorata), a long-lived reptile that is in decline throughout California and the Pacific Northwest. We measured total Hg (THg) concentrations in red blood cells (RBCs) and plasma T3 and T4 of turtles from several locations in California that have been impacted by historic gold mining. Across all turtles from all sites, the geometric mean and standard error THg concentration was 0.805 ± 0.025 μg/g dry weight. Sampling region and mass were the strongest determinants of RBC THg. Relationships between RBC THg and T3 and T4 were consistent with Hg-induced disruption of T4 deiodination, a mechanism of toxicity that may cause excess T4 levels and depressed concentrations of biologically active T3.

  10. Common studied polymorphisms do not affect plasma cytokine levels upon endotoxin exposure in humans

    DEFF Research Database (Denmark)

    Taudorf, Sarah; Krabbe, K.S.; Berg, R.M.

    2008-01-01

    The aim of this study was to investigate to what extent single nucleotide polymorphisms (SNPs) in promoter regions of genes of Toll-like receptor (TLR)-4, tumour necrosis factor (TNF)-alpha, interleukin (IL)-18, interferon (IFN)-gamma, IL-6 and IL-10 affect the cytokine response during a controlled......-607, IFN-gamma+874, IL-6-174, IL-10-592 and IL-10-1082) and endotoxin-induced changes in plasma levels of TNF-alpha, IL-6 and IL-10. IL-18 levels were unaffected by endotoxin. In conclusion, the investigated SNPs did not affect endotoxin-induced low-grade cytokine production of TNF-alpha, IL-6, IL-18 or IL......-10 in healthy young men. Previous reports of a major heritability factor in the inflammatory response may be due to other target genes or effects in older age groups or women Udgivelsesdato: 2008/4...

  11. Recovery of plasma volume after 1 week of exposure at 4,350 m

    DEFF Research Database (Denmark)

    Robach, Paul; Lafforgue, Eric; Olsen, Niels Vidiendal

    2002-01-01

    Plasma volume (PV) decreases at high altitude, but is rapidly restored upon return to sea-level (RSL). The aim of this study was (1) to describe PV recovery upon RSL with concomitant changes in major fluid regulating hormones, and (2) to test the hypothesis that PV recovery is promoted...... natriuretic factor (ANF) and arginine vasopressin (AVP) were measured at rest and during exercise. The subjects were divided into two groups 1 h before RSL, one group receiving PV expansion (475+/-219 ml) to ensure normovolemia (PVX, n=6), the others serving as controls (Control, n=4). PV decreased by 13...... groups, whereas water output dropped in RSL. PVX increased urine flow rate in RSL1 compared with subjects not given PVX. The present results suggest that PV recovery during early RSL is mainly due to a decreased diuresis, promoted at least in part by changes in fluid regulating hormones. However, neither...

  12. Environmental exposure to lead induces oxidative stress and modulates the function of the antioxidant defense system and the immune system in the semen of males with normal semen profile

    Energy Technology Data Exchange (ETDEWEB)

    Kasperczyk, Aleksandra; Dobrakowski, Michał [Dept. of Biochemistry, School of Medicine with the Division of Dentistry, Medical University of Silesia, Katowice, Jordana 19, 41-808 Zabrze (Poland); Czuba, Zenon P. [Dept. of Microbiology and Immunology, School of Medicine with the Division of Dentistry, Medical University of Silesia, Katowice, Jordana 19, 41-808 Zabrze (Poland); Horak, Stanisław [I-st Chair and Clin. Dept. of Gynecology, Obstetrics and Gynecological Oncology, School of Medicine with the Division of Dentistry, Medical University of Silesia, Katowice, Batorego 15, 41-902 Bytom (Poland); Kasperczyk, Sławomir, E-mail: kaslav@mp.pl [Dept. of Biochemistry, School of Medicine with the Division of Dentistry, Medical University of Silesia, Katowice, Jordana 19, 41-808 Zabrze (Poland)

    2015-05-01

    We investigated the associations between environmental exposure to lead and a repertoire of cytokines in seminal plasma of males with normal semen profile according to the WHO criteria. Based on the median lead concentration in seminal plasma, 65 samples were divided into two groups: low (LE) and high exposure to lead (HE). Differences in semen volume and the pH, count, motility and morphology of sperm cells were not observed between the examined groups. The total oxidant status value and the level of protein sulfhydryl groups as well as the activities of manganese superoxide dismutase and catalase were significantly higher in the HE group, whereas the total antioxidant capacity value and the activities of glutathione reductase and glutathione-S-transferase were depressed. IL-7, IL-10, IL-12, and TNF-α levels were significantly higher in the HE group compared with the LE group. Environmental exposure to lead is sufficient to induce oxidative stress in seminal plasma and to modulate antioxidant defense system. - Highlights: • Lead induces oxidative stress in seminal plasma in human. • Lead modulates antioxidant defense system in seminal plasma in human. • Lead does not change a Th1/Th2 imbalance in seminal plasma in human.

  13. Plasma equilibria and stationary flows in axisymmetric systems. Pt. 3

    International Nuclear Information System (INIS)

    Zelazny, R.; Stankiewicz, R.; Galkowski, A.; Potempski, S.; Pietak, R.

    1990-08-01

    The problem of the importance of poloidal flows for the behaviour of plasmas in axisymmetric systems has caused a lot of discussion and controversy during the last 15 years. There is no doubt that the mere existence of poloidal flow transforms the elliptic Grad-Shafranov-Schlueter equation into a system of mixed type partial differential equation and an algebraic multivalued Bernoulli equation. This fact leads to the appearance of Bernoulli branches in the solutions. Then, one can come across three branches of elliptic solutions as well as two branches of hyperbolic solutions with the possible appearance of phenomena connected with ''transsonic'' effects. Problems connected with such a mathematical situation have been extensively discussed in the report with the same title, dated May 1988, which we shall call later Part I of our studies on this subject. The present report, considered as Part III, is devoted to the presentation of results of efforts aimed at constructing programmes which allow us to solve the extended Grad-Shafranov-Schlueter equation (EGSS) (with stationary flows) in a more realistic situation relevant to the JET operating conditions. The main problem is to specify for a wider class of profiles the boundary conditions at the magnetic axis for a system of nonlinear ordinary differential equations ODE, resulting from EGSS equation after application of Fourier transformation techniques and of inverse method approach. The present report elaborates a much more general case and describes the computational framework enabling us to derive those boundary conditions. (author)

  14. The plasma membrane transport systems and adaptation to salinity.

    Science.gov (United States)

    Mansour, Mohamed Magdy F

    2014-11-15

    Salt stress represents one of the environmental challenges that drastically affect plant growth and yield. Evidence suggests that glycophytes and halophytes have a salt tolerance mechanisms working at the cellular level, and the plasma membrane (PM) is believed to be one facet of the cellular mechanisms. The responses of the PM transport proteins to salinity in contrasting species/cultivars were discussed. The review provides a comprehensive overview of the recent advances describing the crucial roles that the PM transport systems have in plant adaptation to salt. Several lines of evidence were presented to demonstrate the correlation between the PM transport proteins and adaptation of plants to high salinity. How alterations in these transport systems of the PM allow plants to cope with the salt stress was also addressed. Although inconsistencies exist in some of the information related to the responses of the PM transport proteins to salinity in different species/cultivars, their key roles in adaptation of plants to high salinity is obvious and evident, and cannot be precluded. Despite the promising results, detailed investigations at the cellular/molecular level are needed in some issues of the PM transport systems in response to salinity to further evaluate their implication in salt tolerance. Copyright © 2014 Elsevier GmbH. All rights reserved.

  15. In-depth methods for systemic exposure predictions

    Science.gov (United States)

    Exposure to a wide range of chemicals is ubiquitous and largely unavoidable within modern society. The potential for human exposure, however, has not been quantified for the vast majority of chemicals with wide commercial use. Creative advances in exposure science are needed to s...

  16. SYSTEMIC IMBALANCE OF ESSENTIAL METALS AND CARDIAC GENE EXPRESSION IN RATS FOLLOWING ACUTE PULMONARY ZINC EXPOSURE

    Science.gov (United States)

    We have recently demonstrated that PM containing water-soluble zinc may cause cardiac injury following pulmonary exposure. To investigate if pulmonary zinc exposure causes systemic metal imbalance and direct cardiac effects, we intratracheally (IT) instilled male Wistar Kyoto (WK...

  17. Systems Analysis of a Compact Next Step Burning Plasma Experiment

    International Nuclear Information System (INIS)

    Jardin, S.C.; Kessel, C.E.; Meade, D.; Neumeyer, C.

    2002-01-01

    A new burning plasma systems code (BPSC) has been developed for analysis of a next step compact burning plasma experiment with copper-alloy magnet technology. We consider two classes of configurations: Type A, with the toroidal field (TF) coils and ohmic heating (OH) coils unlinked, and Type B, with the TF and OH coils linked. We obtain curves of the minimizing major radius as a function of aspect ratio R(A) for each configuration type for typical parameters. These curves represent, to first order, cost minimizing curves, assuming that device cost is a function of major radius. The Type B curves always lie below the Type A curves for the same physics parameters, indicating that they lead to a more compact design. This follows from that fact that a high fraction of the inner region, r < R-a, contains electrical conductor material. However, the fact that the Type A OH and TF magnets are not linked presents fewer engineering challenges and should lead to a more reliable design. Both the Type A and Type B curves have a minimum in major radius R at a minimizing aspect ratio A typically above 2.8 and at high values of magnetic field B above 10 T. The minimizing A occurs at larger values for longer pulse and higher performance devices. The larger A and higher B design points also have the feature that the ratio of the discharge time to the current redistribution time is largest so that steady-state operation can be more realistically prototyped. A sensitivity study is presented for the baseline Type A configuration showing the dependence of the results on the parameters held fixed for the minimization study

  18. Plasma Reforming of Liquid Hydrocarbon Fuels in Non-Thermal Plasma-Liquid Systems

    Science.gov (United States)

    2010-04-30

    channel with liquid wall in the microporous media under the ultrasound cavitations has shown the following: · The action of the ultrasound field in the...microporous liquid which has a very large ratio of the plasma-liquid contact surface to the plasma volume. As is known the ultrasonic (US) cavitation is a very...2) and it ran over a flat dielectric surface of the magnetostrictive transmitter (5) which produced ultrasonic (US) cavitations , so the discharge

  19. Modulation of the Plasma Kallikrein-Kinin System Proteins Performed by Heparan Sulfate Proteoglycans

    OpenAIRE

    Motta, Guacyara; Tersariol, Ivarne L. S.

    2017-01-01

    Human plasma kallikrein-kinin system proteins are related to inflammation through bradykinin. In the proximity of its target cells, high molecular weight kininogen (H-kininogen) is the substrate of plasma kallikrein, which releases bradykinin from H-kininogen. Heparan sulfate proteoglycans (HSPGs) play a critical role in either recruiting kinin precursors from the plasma, or in the assembly of kallikrein-kinin system components on the cell surface. Furthermore, HSPGs mediate the endocytosis a...

  20. Effects of vitamin D3 supplementation and UVb exposure on the growth and plasma concentration of vitamin D3 metabolites in juvenile bearded dragons (Pogona vitticeps)

    NARCIS (Netherlands)

    Oonincx, D.G.A.B.; Stevens, Y.; Borne, van den J.J.G.C.; Leeuwen, van J.P.T.M.; Hendriks, W.H.

    2010-01-01

    The effectiveness of dietary vitamin D3 and UVb exposure on plasma vitamin D metabolites in growing bearded dragons (Pogona vitticeps) was studied. A total of 84 (40 males and 44 females) newly hatched bearded dragons were allocated to six levels of oral vitamin D3 supplementation (0 to 400%) or six

  1. Microprocessor-controlled inhalation system for repeated exposure of animals to aerosols

    International Nuclear Information System (INIS)

    Carpenter, R.L.; Barr, F.P.; Leydig, R.L.; Rajala, R.E.

    1979-01-01

    A microprocessor-controlled inhalation exposure system (MCIES) has been built to automate aerosol generation and sampling while controlling exposure time for animal toxicity studies. The system has a time resolution of 0.1 s and automatically sequences the exposure events from initiation to temination of the exposure. The operator is required to preset all airflows, read in a paper tape containing the time sequence of events, and initiate the automatic sequence by closing a switch

  2. The Plasma Discharge System For Effective Sterilization Of Water And Solid Surfaces

    International Nuclear Information System (INIS)

    Senturk, K.

    2010-01-01

    The different areas such as medicine, surgery, food production need efficient sterilization system since they are directly related to human health. In this work a new plasma system is described in order to present its effectiveness in sterilization. This is a different method from conventional methods such as: chemicals and heat addition, UV irradiation etc. The developed plasma system produces cold plasma working under atmospheric pressure. To generate the plasma both AC and DC high voltage power supplies were used. The developed system is cheap and very effective for sterilization. The light emission for both AC and DC coronas for the plasmas were investigated to understand the nature of generated plasma ionization. Different parameters like temperature, voltage, application time were changed during the plasma application and the optimization for killing the micro-organisms were investigated. To understand the biological effect of plasma on the organisms comparisons were done by using the scanning electron microscope and absorption spectrometer. The plasma was applied on the bacteria like Escherichia coli, Bacillus subtilis, Streptococcus mutans , the yeasts such as Candida albicans, and green algae. The efficiency, the non toxic nature, the affordable price make this plasma discharge method a very efficient one for sterilization.

  3. Systemic serum amyloid A as a biomarker for exposure to zinc and/or copper-containing metal fumes.

    Science.gov (United States)

    Baumann, R; Gube, M; Markert, A; Davatgarbenam, S; Kossack, V; Gerhards, B; Kraus, T; Brand, P

    2018-01-01

    Zinc- and copper-containing welding fumes increase systemic C-reactive protein (CRP). The aim of this study was to investigate the performance of the biomarkers serum amyloid A (SAA) and soluble vascular cell adhesion molecule-1 (VCAM-1) in this regard. Fifteen male subjects were exposed under controlled conditions to welding fumes containing either zinc, or copper, or copper and zinc for 6 h. Plasma samples were collected before, 6 and 24 h after start of exposure and biomarkers therein were measured by electrochemiluminescent assay. For each exposure, systemic concentrations of systemic SAA, but not VCAM-1, increased significantly at 24 h after exposure start compared with baseline ("copper only": P=0.0005, "zinc only": P=0.027, "copper and zinc": P=0.001). SAA showed a wider range of concentrations than did CRP and its levels increased up to 19-fold after welding fume exposure. The recognition of copper as a potential harmful component in welding fumes, also independent from zinc, deserves further consideration. SAA might represent a new sensitive biomarker for potential subclinical sterile inflammation after inhalation of copper- and/or zinc-containing welding fumes. As elevations of CRP and SAA protein have both been linked to a higher risk for cardiovascular disease, these findings might particularly be important for long-term welders.

  4. [Automatic adjustment control system for DC glow discharge plasma source].

    Science.gov (United States)

    Wan, Zhen-zhen; Wang, Yong-qing; Li, Xiao-jia; Wang, Hai-zhou; Shi, Ning

    2011-03-01

    There are three important parameters in the DC glow discharge process, the discharge current, discharge voltage and argon pressure in discharge source. These parameters influence each other during glow discharge process. This paper presents an automatic control system for DC glow discharge plasma source. This system collects and controls discharge voltage automatically by adjusting discharge source pressure while the discharge current is constant in the glow discharge process. The design concept, circuit principle and control program of this automatic control system are described. The accuracy is improved by this automatic control system with the method of reducing the complex operations and manual control errors. This system enhances the control accuracy of glow discharge voltage, and reduces the time to reach discharge voltage stability. The glow discharge voltage stability test results with automatic control system are provided as well, the accuracy with automatic control system is better than 1% FS which is improved from 4% FS by manual control. Time to reach discharge voltage stability has been shortened to within 30 s by automatic control from more than 90 s by manual control. Standard samples like middle-low alloy steel and tin bronze have been tested by this automatic control system. The concentration analysis precision has been significantly improved. The RSDs of all the test result are better than 3.5%. In middle-low alloy steel standard sample, the RSD range of concentration test result of Ti, Co and Mn elements is reduced from 3.0%-4.3% by manual control to 1.7%-2.4% by automatic control, and that for S and Mo is also reduced from 5.2%-5.9% to 3.3%-3.5%. In tin bronze standard sample, the RSD range of Sn, Zn and Al elements is reduced from 2.6%-4.4% to 1.0%-2.4%, and that for Si, Ni and Fe is reduced from 6.6%-13.9% to 2.6%-3.5%. The test data is also shown in this paper.

  5. Transforming the ASDEX Upgrade discharge control system to a general-purpose plasma control platform

    International Nuclear Information System (INIS)

    Treutterer, Wolfgang; Cole, Richard; Gräter, Alexander; Lüddecke, Klaus; Neu, Gregor; Rapson, Christopher; Raupp, Gerhard; Zasche, Dieter; Zehetbauer, Thomas

    2015-01-01

    Highlights: • Control framework split in core and custom part. • Core framework deployable in other fusion device environments. • Adaptible through customizable modules, plug-in support and generic interfaces. - Abstract: The ASDEX Upgrade Discharge Control System DCS is a modern and mature product, originally designed to regulate and supervise ASDEX Upgrade Tokamak plasma operation. In its core DCS is based on a generic, versatile real-time software framework with a plugin architecture that allows to easily combine, modify and extend control function modules in order to tailor the system to required features and let it continuously evolve with the progress of an experimental fusion device. Due to these properties other fusion experiments like the WEST project have expressed interest in adopting DCS. For this purpose, essential parts of DCS must be unpinned from the ASDEX Upgrade environment by exposure or introduction of generalised interfaces. Re-organisation of DCS modules allows distinguishing between intrinsic framework core functions and device-specific applications. In particular, DCS must be prepared for deployment in different system environments with their own realisations for user interface, pulse schedule preparation, parameter server, time and event distribution, diagnostic and actuator systems, network communication and data archiving. The article explains the principles of the revised DCS structure, derives the necessary interface definitions and describes major steps to achieve the separation between general-purpose framework and fusion device specific components.

  6. Transforming the ASDEX Upgrade discharge control system to a general-purpose plasma control platform

    Energy Technology Data Exchange (ETDEWEB)

    Treutterer, Wolfgang, E-mail: Wolfgang.Treutterer@ipp.mpg.de [Max-Planck-Institut für Plasmaphysik, Boltzmannstr. 2, 85748 Garching (Germany); Cole, Richard [Unlimited Computer Systems, Seeshaupter Str. 15, 82393 Iffeldorf (Germany); Gräter, Alexander [Max-Planck-Institut für Plasmaphysik, Boltzmannstr. 2, 85748 Garching (Germany); Lüddecke, Klaus [Unlimited Computer Systems, Seeshaupter Str. 15, 82393 Iffeldorf (Germany); Neu, Gregor; Rapson, Christopher; Raupp, Gerhard; Zasche, Dieter; Zehetbauer, Thomas [Max-Planck-Institut für Plasmaphysik, Boltzmannstr. 2, 85748 Garching (Germany)

    2015-10-15

    Highlights: • Control framework split in core and custom part. • Core framework deployable in other fusion device environments. • Adaptible through customizable modules, plug-in support and generic interfaces. - Abstract: The ASDEX Upgrade Discharge Control System DCS is a modern and mature product, originally designed to regulate and supervise ASDEX Upgrade Tokamak plasma operation. In its core DCS is based on a generic, versatile real-time software framework with a plugin architecture that allows to easily combine, modify and extend control function modules in order to tailor the system to required features and let it continuously evolve with the progress of an experimental fusion device. Due to these properties other fusion experiments like the WEST project have expressed interest in adopting DCS. For this purpose, essential parts of DCS must be unpinned from the ASDEX Upgrade environment by exposure or introduction of generalised interfaces. Re-organisation of DCS modules allows distinguishing between intrinsic framework core functions and device-specific applications. In particular, DCS must be prepared for deployment in different system environments with their own realisations for user interface, pulse schedule preparation, parameter server, time and event distribution, diagnostic and actuator systems, network communication and data archiving. The article explains the principles of the revised DCS structure, derives the necessary interface definitions and describes major steps to achieve the separation between general-purpose framework and fusion device specific components.

  7. Using plasma-fuel systems at Eurasian coal-fired thermal power stations

    Science.gov (United States)

    Karpenko, E. I.; Karpenko, Yu. E.; Messerle, V. E.; Ustimenko, A. B.

    2009-06-01

    The development of plasma technology for igniting solid fuels at coal-fired thermal power stations in Russia, Kazakhstan, China, and other Eurasian countries is briefly reviewed. Basic layouts and technical and economic characteristics of plasma-fuel systems installed in different coal-fired boiles are considered together with some results from using these systems at coal-fired thermal power stations.

  8. Advanced Thomson scattering system for high-flux linear plasma generator

    NARCIS (Netherlands)

    Meiden, van der H.J.; Lof, A.R.; Berg, van den M.A.; Brons, S.; Donné, A.J.H.; Eck, van H.J.N.; Koelman, Peter; Koppers, W.R.; Kruijt, O.G.; Naumenko, N.N.; Oyevaar, T.; Prins, P.R.; Rapp, J.; Scholten, J.; Schram, D.C.; Smeets, P.H.M.; Star, van der G.; Tugarinov, S.N.; Zeijlmans van Emmichoven, P.A.

    2012-01-01

    An advanced Thomson scattering system has been built for a linear plasma generator for plasma surface interaction studies. The Thomson scattering system is based on a Nd:YAG laser operating at the second harmonic and a detection branch featuring a high etendue (f /3) transmission grating

  9. VME multiprocessor system for plasma control at the JT-60 Upgrade

    International Nuclear Information System (INIS)

    Kimura, T.; Kurihara, K.; Takahashi, M.; Kawamata, Y.; Akasaka, H.; Matsukawa, M.

    1989-01-01

    In this paper design and preliminary tests are reported of a VME multiprocessor system for the JT-60 Upgrade plasma control utilizing three MC88100 based RISC computers and VME buses. The design of the VME system was stimulated by faster and more accurate computation requirements for the plasma position and shape control

  10. Photoluminescence recovery by in-situ exposure of plasma-damaged n-GaN to atomic hydrogen at room temperature

    Directory of Open Access Journals (Sweden)

    Shang Chen

    2012-06-01

    Full Text Available The effect of in-situ exposure of n-GaN damaged by Cl2 plasma to atomic hydrogen (H radicals at room temperature was investigated. We found that the PL intensities of the band-edge emission, which had been drastically reduced by plasma-beam irradiation at a Cl ion dose of 5 × 1016 cm−2, recovered to values close to those of as-grown samples after H radical exposure at a dose of 3.8 × 1017 cm−2. XPS revealed the appearance of a peak at a binding energy of 18.3 eV, which is tentatively assigned to Ga-H, and confirmed the removal of Cl after H radical exposure.

  11. Physics of the conceptual design of the ITER plasma control system

    Energy Technology Data Exchange (ETDEWEB)

    Snipes, J.A., E-mail: Joseph.Snipes@iter.org [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); Bremond, S. [CEA-IRFM, 13108 St Paul-lez-Durance (France); Campbell, D.J. [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); Casper, T. [1166 Bordeaux St, Pleasanton, CA 94566 (United States); Douai, D. [CEA-IRFM, 13108 St Paul-lez-Durance (France); Gribov, Y. [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); Humphreys, D. [General Atomics, San Diego, CA 92186 (United States); Lister, J. [Association EURATOM-Confédération Suisse, Ecole Polytechnique Fédérale de Lausanne (EPFL), CRPP, Lausanne CH-1015 (Switzerland); Loarte, A.; Pitts, R. [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); Sugihara, M., E-mail: Sugihara_ma@yahoo.co.jp [Japan (Japan); Winter, A.; Zabeo, L. [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France)

    2014-05-15

    Highlights: • ITER plasma control system conceptual design has been finalized. • ITER's plasma control system will evolve with the ITER research plan. • A sophisticated actuator sharing scheme is being developed to apply multiple coupled control actions simultaneously with a limited set of actuators. - Abstract: The ITER plasma control system (PCS) will play a central role in enabling the experimental program to attempt to sustain DT plasmas with Q = 10 for several hundred seconds and also support research toward the development of steady-state operation in ITER. The PCS is now in the final phase of its conceptual design. The PCS relies on about 45 diagnostic systems to assess real-time plasma conditions and about 20 actuator systems for overall control of ITER plasmas. It will integrate algorithms required for active control of a wide range of plasma parameters with sophisticated event forecasting and handling functions, which will enable appropriate transitions to be implemented, in real-time, in response to plasma evolution or actuator constraints. In specifying the PCS conceptual design, it is essential to define requirements related to all phases of plasma operation, ranging from early (non-active) H/He plasmas through high fusion gain inductive plasmas to fully non-inductive steady-state operation, to ensure that the PCS control functionality and architecture will be capable of satisfying the demands of the ITER research plan. The scope of the control functionality required of the PCS includes plasma equilibrium and density control commonly utilized in existing experiments, control of the plasma heat exhaust, control of a range of MHD instabilities (including mitigation of disruptions), and aspects such as control of the non-inductive current and the current profile required to maintain stable plasmas in steady-state scenarios. Control areas are often strongly coupled and the integrated control of the plasma to reach and sustain high plasma

  12. Physics of the conceptual design of the ITER plasma control system

    International Nuclear Information System (INIS)

    Snipes, J.A.; Bremond, S.; Campbell, D.J.; Casper, T.; Douai, D.; Gribov, Y.; Humphreys, D.; Lister, J.; Loarte, A.; Pitts, R.; Sugihara, M.; Winter, A.; Zabeo, L.

    2014-01-01

    Highlights: • ITER plasma control system conceptual design has been finalized. • ITER's plasma control system will evolve with the ITER research plan. • A sophisticated actuator sharing scheme is being developed to apply multiple coupled control actions simultaneously with a limited set of actuators. - Abstract: The ITER plasma control system (PCS) will play a central role in enabling the experimental program to attempt to sustain DT plasmas with Q = 10 for several hundred seconds and also support research toward the development of steady-state operation in ITER. The PCS is now in the final phase of its conceptual design. The PCS relies on about 45 diagnostic systems to assess real-time plasma conditions and about 20 actuator systems for overall control of ITER plasmas. It will integrate algorithms required for active control of a wide range of plasma parameters with sophisticated event forecasting and handling functions, which will enable appropriate transitions to be implemented, in real-time, in response to plasma evolution or actuator constraints. In specifying the PCS conceptual design, it is essential to define requirements related to all phases of plasma operation, ranging from early (non-active) H/He plasmas through high fusion gain inductive plasmas to fully non-inductive steady-state operation, to ensure that the PCS control functionality and architecture will be capable of satisfying the demands of the ITER research plan. The scope of the control functionality required of the PCS includes plasma equilibrium and density control commonly utilized in existing experiments, control of the plasma heat exhaust, control of a range of MHD instabilities (including mitigation of disruptions), and aspects such as control of the non-inductive current and the current profile required to maintain stable plasmas in steady-state scenarios. Control areas are often strongly coupled and the integrated control of the plasma to reach and sustain high plasma

  13. Strategies to assess systemic exposure of chemicals in subchronic/chronic diet and drinking water studies

    International Nuclear Information System (INIS)

    Saghir, Shakil A.; Mendrala, Alan L.; Bartels, Michael J.; Day, Sue J.; Hansen, Steve C.; Sushynski, Jacob M.; Bus, James S.

    2006-01-01

    Strategies were developed for the estimation of systemically available daily doses of chemicals, diurnal variations in blood levels, and rough elimination rates in subchronic feeding/drinking water studies, utilizing a minimal number of blood samples. Systemic bioavailability of chemicals was determined by calculating area under the plasma concentration curve over 24 h (AUC-24 h) using complete sets of data (≥5 data points) and also three, two, and one selected time points. The best predictions of AUC-24 h were made when three time points were used, corresponding to C max , a mid-morning sample, and C min . These values were found to be 103 ± 10% of the original AUC-24 h, with 13 out of 17 values ranging between 96 and 105% of the original. Calculation of AUC-24 h from two samples (C max and C min ) or one mid-morning sample afforded slightly larger variations in the calculated AUC-24 h (69-136% of the actual). Following drinking water exposure, prediction of AUC-24 h using 3 time points (C max , mid-morning, and C min ) was very close to actual values (80-100%) among mice, while values for rats were only 63% of the original due to less frequent drinking behavior of rats during the light cycle. Collection and analysis of 1-3 blood samples per dose may provide insight into dose-proportional or non-dose-proportional differences in systemic bioavailability, pointing towards saturation of absorption or elimination or some other phenomenon warranting further investigation. In addition, collection of the terminal blood samples from rats, which is usually conducted after 18 h of fasting, will be helpful in rough estimation of blood/plasma half-life of the compound. The amount of chemical(s) and/or metabolite(s) in excreta and their possible use as biomarkers in predicting the daily systemic exposure levels are also discussed. Determining these parameters in the early stages of testing will provide critical information to improve the appropriate design of other longer

  14. Sintering, consolidation, reaction and crystal growth by the spark plasma system (SPS)

    Energy Technology Data Exchange (ETDEWEB)

    Omori, M. [Tohoku Univ., Sendai (Japan). Inst. for Materials Research

    2000-08-15

    The graphite die set in spark plasma system (SPS) is heated by a pulse direct current. Weak plasma, discharge impact, electric field and electric current, which are based on this current, induce good effects on materials in the die. The surface films of aluminum and pure WC powders are ruptured by the spark plasma. Pure AlN powder is sintered without sintering additives in the electric field. The spark plasma leaves discharge patterns on insulators. Organic fibers are etched by the spark plasma. Thermosetting polyimide is consolidated by the spark plasma. Insoluble polymonomethylsilane is rearranged into the soluble one by the spark plasma. A single crystal of CoSb{sub 3} is grown from the compound powders in the electric field by slow heating. Coupled crystals of eutectic powder are connected with each other in the electric field. (orig.)

  15. Short communication: Artificial ultraviolet B light exposure increases vitamin D levels in cow plasma and milk

    DEFF Research Database (Denmark)

    Jakobsen, Jette; Jensen, Søren Krogh; Hymøller, Lone

    2015-01-01

    tested the ability of a specially designed UVB lamp to enhance the vitamin D-3 content in milk from dairy cows housed indoors. This study included 16 cows divided into 4 groups. Each group was exposed daily to artificial UVB light simulating 1, 2, 3, or 4 h of summer sun at 56 degrees N for 24 d...... exposure to artificial UVB light to 73 d did not lead to an increase of vitamin D-3 or 25OHD(3) level in the milk. In conclusion, the change in production facilities for dairy cows providing cows with no access to pasture and sunlight causes a decrease of vitamin D levels in dairy products. This decrease......The number of dairy cows without access to pasture or sunlight is increasing; therefore, the content of vitamin D in dairy products is decreasing. Ultimately, declining vitamin D levels in dairy products will mean that dairy products are a negligible source of natural vitamin D for humans. We...

  16. Assessing exposure to cosmic radiation aboard aircraft: the SIEVERT system

    International Nuclear Information System (INIS)

    Bottolier-Depois, J.F.; Clairand, I.; Blanchard, P.; Dessarps, P.; Lantos, P.

    2005-01-01

    Full text: The study of naturally-occurring radiation and its associated risk is one of the preoccupations of bodies responsible for radiation protection. Cosmic particle flux is significantly higher on board aircraft that at ground level. Furthermore, its intensity depends on solar activity and eruptions. Due to their professional activity, flight crews and frequent flyers may receive an annual dose of some milliSieverts. This is why the European directive adopted in 1996 requires the aircraft operators to assess the dose and to inform their flight crews about the risk. The effective dose is to be estimated using various experimental and calculation means. In France, the computerized system for flight assessment of exposure to cosmic radiation in air transport (SIEVERT) is delivered to airlines for assisting them in the application of the European directive. This dose assessment tool was developed by the French General Directorate of Civil Aviation (DGAC) and partners: the Institute for Radiation Protection and Nuclear Safety (IRSN), the Paris Observatory and the French Institute for Polar Research - PaulEmile Victor (IPEV). This professional service is available since more than two years on an Internet server accessible to companies with a public section. The system provides doses that consider the routes flown by aircraft. Various results obtained are presented: experimental validation, in particular for the ground level event model (large solar eruption), and statistics on routes and personal doses. (author)

  17. Assessing exposure to cosmic radiation aboard aircraft: the Sievert system

    International Nuclear Information System (INIS)

    Bottollier-Depois, J.F.; Biau, A.; Clairand, I.; Saint-Lo, D.; Valero, M.; Blanchard, P.; Dessarps, P.; Lantos, P.

    2003-01-01

    The study of naturally-occurring radiation and its associated risk is one of the preoccupations of bodies responsible for radiation protection. Cosmic particle flux is significantly higher on board aircraft that at ground level. Furthermore, its intensity depends on solar activity and eruptions. Due to their professional activity, flight crews and frequent flyers may receive an annual dose of some milli-sieverts. This is why the European directive adopted in 1996 requires the aircraft operators to assess the dose and to inform their flight crews about the risk. The effective dose is to be estimated using various experimental and calculation means. In France, the computerized system for flight assessment of exposure to cosmic radiation in air transport (SIEVERT) is delivered to airlines for assisting them in the application of the European directive. This dose assessment tool was developed by the French General Directorate of Civil Aviation (DGAC) and partners: the Institute for Radiation Protection and Nuclear Safety (IRSN), the Paris Observatory and the French Institute for Polar Research - Paul-Emile Victor (IPEV). This professional service is available on an Internet server accessible to companies with a public section. The system provides doses that consider the routes flown by aircraft Various results obtained are presented. (authors)

  18. Occupational exposure and effects on the male reproductive system

    Directory of Open Access Journals (Sweden)

    Erika Kaltenecker Retto de Queiroz

    Full Text Available A significant increase in the incidence of male infertility has been described in the international literature, raising questions about its causes. Part of this effect may result from synthetic toxic substances acting on the endocrine system (endocrine disruptors, many of which are routinely used in work processes. We provide a critical review of the specialized literature on work-related chemical substances capable of causing male infertility. Pesticides such as DDT, linuron, and others, heavy metals like mercury, lead, cadmium, and copper, and substances from various industrial uses and residues such as dioxins, polychlorinated biphenyls (PCBs, ethylene dibromide (EDB, phthalates, polyvinyl chloride (PVC, and ethanol are among the main endocrine disruptors that can cause male infertility. Based on the literature, gonadal dysfunction and congenital malformation are the main alterations caused by these substances in the male reproductive system. We conclude that despite the relative lack of studies on this issue, the relevance of such risk calls for further studies as well as measures to prevent workers' exposure to the various substances.

  19. Plasma control system for 'Day-One' operation of KSTAR tokamak

    International Nuclear Information System (INIS)

    Hahn, Sang-hee; Walker, M.L.; Kim, Kukhee; Ahn, H.S.; Penaflor, B.G.; Piglowski, D.A.; Johnson, R.D.; Choi, Jaehoon; Lee, Dong-keun; Kim, Jayhyun; Yoon, S.W.; Seo, Seong-Heon; Kim, H.T.; Kim, K.P.; Lee, T.G.; Park, M.K.; Bak, J.G.; Lee, S.G.; Nam, Y.U.; Eidietis, N.W.

    2009-01-01

    A complete plasma control system (PCS) has been developed for KSTAR's first plasma campaign as a collaborative project with the DIII-D team. The KSTAR real time plasma control system is based on a conceptual design by Jhang and Choi [Hogun Jhang, I.S. Choi, Fusion Engineering and Design 73 (2005) 35-49] and consists of a fast real-time computer/communication cluster and software derived from the GA-PCS [Penaflor, B.G., et.al., Fusion Engineering and Design, 83 (2) (2008) 176]. The system has been used for simulation testing, poloidal field (PF) coil power supply commissioning and first plasma control. The seven sets of up-down symmetric, superconducting PF coil/power supply systems have been successfully tested. Reflective memory (RFM) is utilized as the primary actuator/PCS real-time communication layer and PCS synchronization with KSTAR timing system and slower control devices is achieved through an EPICS implementation. Consistent feedback loop times of 100 microseconds has been achieved during PF coil power supply testing and first plasma commissioning. Here we present the 'Day-One' plasma control system in its final form for the first plasma experimental campaign of KSTAR and describe how the system has been utilized during magnet commissioning and plasma startup experiments.

  20. A review of automatic exposure control of conventional and digital systems

    International Nuclear Information System (INIS)

    Workman, A.; Cowen, A.R.

    1989-01-01

    The desirable properties and methods of achieving automatic exposure control in film-screen radiography, fluoroscopy, spot-film fluorography and cinefluorography are discussed. Advantages of certain methods in achieving optimum image quality for minimal patient exposure are considered. In digital subtraction fluorography (DSF) where relatively large exposure levels per image are used, proper set-up of exposure conditions is of particular importance. These systems require a high degree of stability in exposure to maintain a high level of image quality. We have developed test methods for monitoring the set-up and reproducibility of exposure levels in DSF. (author)

  1. Laser-Based Optical System for Reactive Radical Concentration Measurements in Plasmas and Flames

    National Research Council Canada - National Science Library

    Fridman, Alexander

    2006-01-01

    Defense University Research Instrumentation Program (DURIP) funding was used to assemble a multi-purpose optical diagnostic system for in-situ radical concentration measurements in plasma and combustion systems...

  2. A dissipative model of plasma equilibrium in toroidal systems

    International Nuclear Information System (INIS)

    Wobig, H.

    1985-10-01

    In order to describe a steady-state plasma equilibrium in tokamaks, stellarators or other non-axisymmetric configurations, the model of ideal MHD with isotropic plasma pressure is widely used. The ideal MHD - model of a toroidal plasma equilibrium requires the existence of closed magnetic surfaces. Several numerical codes have been developed in the past to solve the three-dimensional equilibrium problem, but so far no existence theorem for a solution has been proved. Another difficulty is the formation of magnetic islands and field line ergodisation, which can only be described in terms of ideal MHD if the plasma pressure is constant in the ergodic region. In order to describe the formation of magnetic islands and ergodisation of surfaces properly, additional dissipative terms have to be incorporated to allow decoupling of the plasma and magnetic field. In a collisional plasma viscosity and inelastic collisions introduce such dissipative processes. In the model used a friction term proportional to the velocity v vector of the plasma is included. Such a term originates from charge exchange interaction of the plasma with a nuetral background. With these modifications, the equilibrium problem reduces to a set of quasilinear elliptic equations for the pressure, the electric potential and the magnetic field. The paper deals with an existence theorem based on the Fixed - Point method of Schauder. It can be shown that a self-consistent and unique equilibrium exists if the friction term is large and the plasma pressure is sufficiently low. The essential role of the dissipative terms is to remove the singularities of the ideal MHD model on rational magnetic surfaces. The problem has a strong similarity to Benard cell convection, and consequently similar behaviour such as bifurcation and exchange of stability are expected. (orig./GG)

  3. System and method for generating steady state confining current for a toroidal plasma fusion reactor

    International Nuclear Information System (INIS)

    Fisch, N.J.

    1981-01-01

    A system for generating steady state confining current for a toroidal plasma fusion reactor providing steady-state generation of the thermonuclear power. A dense, hot toroidal plasma is initially prepared with a confining magnetic field with toroidal and poloidal components. Continuous wave rf energy is injected into said plasma to establish a spectrum of traveling waves in the plasma, where the traveling waves have momentum components substantially either all parallel, or all anti-parallel to the confining magnetic field. The injected rf energy is phased to couple to said traveling waves with both a phase velocity component and a wave momentum component in the direction of the plasma traveling wave components. The injected rf energy has a predetermined spectrum selected so that said traveling waves couple to plasma electrons having velocities in a predetermined range delta . The velocities in the range are substantially greater than the thermal electron velocity of the plasma. In addition, the range is sufficiently broad to produce a raised plateau having width delta in the plasma electron velocity distribution so that the plateau electrons provide steady-state current to generate a poloidal magnetic field component sufficient for confining the plasma. In steady state operation of the fusion reactor, the fusion power density in the plasma exceeds the power dissipated in the plasma

  4. System and method for generating steady state confining current for a toroidal plasma fusion reactor

    International Nuclear Information System (INIS)

    Bers, A.

    1981-01-01

    A system for generating steady state confining current for a toroidal plasma fusion reactor providing steady-state generation of the thermonuclear power. A dense, hot toroidal plasma is initially prepared with a confining magnetic field with toroidal and poloidal components. Continuous wave rf energy is injected into said plasma to estalish a spectrum of traveling waves in the plasma, where the traveling waves have momentum components substantially either all parallel, or all anti-parallel to the confining magnetic field. The injected rf energy is phased to couple to said traveling waves with both a phase velocity component and a wave momentum component in the direction of the plasma traveling wave components. The injected rf energy has a predetermined spectrum selected so that said traveling waves couple to plasma electrons having velocities in a predetermined range delta . The velocities in the range are substantially greater than the thermal electron velocity of the plasma. In addition, the range is sufficiently broad to produce a raised plateau having width delta in the plasma electron velocity distribution so that the plateau electrons provide steady-state current to generate a poloidal magnetic field component sufficient for confining the plasma. In steady state operation of the fusion reactor, the fusion power density in the plasma exceeds the power dissipated inthe plasma

  5. Effect of styrene exposure on plasma parameters, molecular mechanisms and gene expression in rat model islet cells.

    Science.gov (United States)

    Niaz, Kamal; Hassan, Fatima Ismail; Mabqool, Faheem; Khan, Fazlullah; Momtaz, Saeideh; Baeeri, Maryam; Navaei-Nigjeh, Mona; Rahimifard, Mahban; Abdollahi, Mohammad

    2017-09-01

    Styrene is an aromatic hydrocarbon compound present in the environment and have primary exposure through plastic industry. The current study was designed to evaluate styrene-induced toxicity parameters in rat plasma fasting blood glucose (FBG) level, oral glucose tolerance, insulin secretion, oxidative stress, and inflammatory cytokines in cellular and molecular levels. Styrene was dissolved in corn oil and administered at different doses (250, 500, 1000, 1500, 2000mg/kg/day and control) to each rat, for 42days. In treated groups, styrene significantly increased fasting blood glucose, plasma insulin (p<0.001) and glucose tolerance. Glucose tolerance, insulin resistance and hyperglycemia were found to be the main consequences correlating gene expression of islet cells. Styrene caused a significant enhancement of oxidative stress markers (p<0.001) and inflammatory cytokines in a dose and concentration-dependent manner in plasma (p<0.001). Moreover, the activities of caspase-3 and -9 of the islet cells were significantly up-regulated by this compound at 1500 and 2000mg/kg/day styrene administrated groups (p<0.001). The relative fold change of GLUD1 was downregulated (p<0.05) and upregulated at 1500 and 2000mg/kg, respectively (p<0.01). The relative fold changes of GLUT2 were down regulated at 250 and 1000mg/kg and up regulated in 500, 1500 and 2000mg/kg doses of styrene (p<0.01). The expression level of GCK indicated a significant upregulation at 250mg/kg and downregulation of relative fold changes in the remaining doses of styrene, except for no change at 2000mg/kg of styrene for GCK. Targeting genes (GLUD1, GLUT2 and GCK) of the pancreatic islet cells in styrene exposed groups, disrupted gluconeogenesis, glycogenolysis pathways and insulin secretory functions. The present study illustrated that fasting blood glucose, insulin pathway, oxidative balance, inflammatory cytokines, cell viability and responsible genes of glucose metabolism are susceptible to styrene

  6. Effects of a two-hour early awakening and of bright light exposure on plasma patterns of cortisol, melatonin, prolactin and testosterone in man.

    Science.gov (United States)

    Touitou, Y; Benoit, O; Foret, J; Aguirre, A; Bogdan, A; Clodoré, M; Touitou, C

    1992-03-01

    Bright light is a synchronizing agent that entrains human circadian rhythms and modifies various endocrine and neuroendocrine functions. The aim of the present study was to determine whether and how the exposure to a bright light stimulus during the 2 h following a 2 h earlier awakening could modify the disturbance induced by the the sleep deprivation on the plasma patterns of hormones whose secretion is sensitive to light and/or sleep, namely melatonin, prolactin, cortisol and testosterone. Six healthy and synchronized (lights on: 07.00-23.00) male students (22.5 +/- 1.1 years) with normal psychological profiles volunteered for the study in winter. The protocol consisted of a baseline control night (customary sleep schedule) followed by three shortened nights with a rising at 05.00 and a 2 h exposure to either dim light (50 lux; one week) or bright light (2000 lux; other week). Our study showed a phase advance of the circadian rhythm of plasma cortisol without significant modifications of the hormone mean or peak concentration. Plasma melatonin concentration decreased following bright light exposure, whereas no obvious modifications of plasma testosterone or prolactin patterns could be observed in this protocol.

  7. Plasma-liquid system with reverse vortex flow of 'tornado' type (TORNADO-LE)

    International Nuclear Information System (INIS)

    Nedybalyuk, O.A.; Chernyak, V.Ya.; Olszewski, S.V.

    2010-01-01

    The results of experimental investigations of the plasma in plasma-liquid system with reverse vortex flow of 'tornado' type are presented. Volt-ampere characteristic of discharge in the current range from 200 to 400 mA were measured. Emission spectra of plasma in range from 200 to 1100 nm were measured. Excitation temperatures (electronic T e * , vibrational T v * and rotational T r * ) were obtained. Emission spectra of hydroxyl OH were calculated.

  8. Radio emission from a helical electron beam-plasma system in a twisted magnetic field

    International Nuclear Information System (INIS)

    Krishan, V.

    1982-01-01

    The excitation of electromagnetic radiation near the harmonics of electron plasma frequency from a helical electron beam travelling parallel to a helical magnetic field through a stationary inhomogeneous plasma is studied. The motivation behind this study is to explain the observed characteristics of the type III solar radio bursts and thus to predict the nature of the plasma system responsible for the generation of these radio bursts. (author)

  9. Effects on respiratory system due to exposure to wheat flour

    Directory of Open Access Journals (Sweden)

    Adel Mohammed Said

    2017-07-01

    Conclusions: Exposure to wheat flour increases the risk of developing respiratory symptoms; it also causes reduction in the pulmonary function parameters, as regards spirometry and DLCOSB. Exposure to wheat flour causes interstitial lung disease as detected by HRCT chest. Smoking augments the wheat flour induced lung disease.

  10. Computer-controlled system for plasma ion energy auto-analyzer

    International Nuclear Information System (INIS)

    Wu Xianqiu; Chen Junfang; Jiang Zhenmei; Zhong Qinghua; Xiong Yuying; Wu Kaihua

    2003-01-01

    A computer-controlled system for plasma ion energy auto-analyzer was technically studied for rapid and online measurement of plasma ion energy distribution. The system intelligently controls all the equipments via a RS-232 port, a printer port and a home-built circuit. The software designed by LabVIEW G language automatically fulfils all of the tasks such as system initializing, adjustment of scanning-voltage, measurement of weak-current, data processing, graphic export, etc. By using the system, a few minutes are taken to acquire the whole ion energy distribution, which rapidly provide important parameters of plasma process techniques based on semiconductor devices and microelectronics

  11. Effect of plasma on the superconductive property of YBCO system

    International Nuclear Information System (INIS)

    Chaudhary, K.A.; Anwar, M.I.; Zakaullah, M.; Alamgir, K.; Murtaza, G.; Haq, A.U.

    1999-01-01

    Oxygen deficient Y/sub 1/Ba/sub 2/Cu 3/O/sub 7-x/ samples are exposed to the rarefied are discharge. The air plasma has gas and electron temperatures as 170 deg. C and 2.1 eV, respectively. As a result of plasma treatment the semiconducting tetragonal phase transformed into superconducting orthorhombic phase with Tc= 84K the phase relating properties have been investigated by monochromated X-ray diffraction and low temperature resistivity measurements. (author)

  12. Proposed alternatives for a DOE-wide occupational radiation exposure information system

    International Nuclear Information System (INIS)

    Murphy, B.L.; Murphy, D.W.; Fix, J.J.; Selby, J.M.; Vallario, E.J.

    1984-02-01

    The Radiation Exposure Information Reporting System (REIRS) was initiated by the Atomic Energy Commission (AEC) in 1968. While the system has provided a general overview of radiation exposures associated with AEC/ERDA/DOE operations and has satisfied the original intent for a central information system, the need for more detailed information has become evident. The alternatives addressed for a radiation exposure information system were no change in current system, clarification of DOE Order for current system, increased summary information from sites, centralized annual individual dose (exposure) system, and annual dose summary and locator files. A majority of the DOE Ad Hoc Committee has concurred to recommend the annual dose summary and locator files (ADSLF). The acceptance of the ADSLF alternative as the DOE-wide radiation exposure system would give DOE added capability and flexibility in responding to requests for information and would reduce the impact on the sites of special survey requests

  13. Effects of vitamin D3 supplementation and UVb exposure on the growth and plasma concentration of vitamin D3 metabolites in juvenile bearded dragons (Pogona vitticeps).

    Science.gov (United States)

    Oonincx, D G A B; Stevens, Y; van den Borne, J J G C; van Leeuwen, J P T M; Hendriks, W H

    2010-06-01

    The effectiveness of dietary vitamin D3 and UVb exposure on plasma vitamin D metabolites in growing bearded dragons (Pogona vitticeps) was studied. A total of 84 (40 males and 44 females) newly hatched bearded dragons were allocated to six levels of oral vitamin D3 supplementation (0 to 400%) or six UVb exposure times (2 to 12 h). At 3 and 6 months of age, blood samples were obtained from each animal and analysed for 25(OH)D3 and 1,25(OH)2D3. At 3 months of age, plasma concentrations of 25(OH)D3 did not increase with increasing vitamin D3 supplementation unlike the 1,25(OH)2D3. At 6 months of age, plasma concentrations of both 25(OH)D(3) and 1,25(OH)2D3 increased with increasing vitamin D(3) supplementation. Plasma concentrations in UVb-exposed animals were 18 times higher for 25(OH)D3 (178.4+/-9.0 vs. 9.9+/-1.3 nmol/L) and 5.3 times higher for 1,25(OH)2D3 (1.205+/-0.100 vs. 0.229+/-0.025 nmol/L) than in vitamin D(3) supplemented animals at 6 months of age. This study shows that 2h of UVb exposure enables adequate physiological concentrations of plasma vitamin D metabolites to be maintained in growing bearded dragons. Oral supplementation of vitamin D(3) is ineffective in raising plasma concentrations of 25(OH)D3 and 1,25(OH)2D3 to concentrations observed in UVb-exposed animals. 2010 Elsevier Inc. All rights reserved.

  14. Simulation of the Plasma Meniscus with and without Space Charge using Triode Extraction System

    International Nuclear Information System (INIS)

    Abdel Rahman, M.M.; EI-Khabeary, H.

    2007-01-01

    In this work simulation of the singly charged argon ion trajectories for a variable plasma meniscus is studied with and without space charge for the triode extraction system by using SIMION 3D (Simulation of Ion Optics in Three Dimensions) version 7 personal computer program. Tbe influence of acceleration voltage applied to tbe acceleration electrode of the triode extraction system on the shape of the plasma meniscus has been determined. The plasma electrode is set at +5000 volt and the acceleration voltage applied to the acceleration electrode is varied from -5000 volt to +5000 volt. In the most of the concave and convex plasma shapes ion beam emittance can be calculated by using separate standard deviations of positions and elevations angles. Ion beam emittance as a function of the curvature of the plasma meniscus for different plasma shapes ( flat concave and convex ) without space change at acceleration voltage varied from -5000 volt to +5000 volt applied to the acceleration electrode of the triode extraction system has been investigated. Tbe influence of the extraction gap on ion beam emittance for a plasma concave shape of 3.75 mm without space charge at acceleration voltage, V a cc = -2000 volt applied to the acceleration electrode of the triode extraction system has been determined. Also the influence of space charge on ion beam emittance for variable plasma meniscus at acceleration voltage, V a cc = - 2000 volt applied to the acceleration electrode of. the triode extraction system has been studied

  15. Simulation of the plasma meniscus with and without space charge using triode extraction system

    International Nuclear Information System (INIS)

    Rahman, M.M.Abdel; El-Khabeary, H.

    2009-01-01

    In this work, simulation of the singly charged argon ion trajectories for a variable plasma meniscus is studied with and without space charge for the triode extraction system by using SIMION 3D (Simulation of Ion Optics in Three Dimensions) version 7 personal computer program. The influence of acceleration voltage applied to the acceleration electrode of the triode extraction system on the shape of the plasma meniscus has been determined. The plasma electrode is set at +5000 volt and the acceleration voltage applied to the acceleration electrode is varied from -5000 volt to +5000 volt. In the most of the concave and convex plasma shapes, ion beam emittance can be calculated by using separate standard deviations of positions and elevations angles. Ion beam emittance as a function of the curvature of the plasma meniscus for different plasma shapes ( flat, concave and convex ) without space charge at acceleration voltage varied from -5000 volt to +5000 volt applied to the acceleration electrode of the triode extraction system has been investigated. The influence of the extraction gap on ion beam emittance for a plasma concave shape of 3.75 mm without space charge at acceleration voltage, V acc = -2000 volt applied to the acceleration electrode of the triode extraction system has been determined. Also the influence of space charge on ion beam emittance for variable plasma meniscus at acceleration voltage, V acc = -2000 volt applied to the acceleration electrode of the triode extraction system has been studied. (author)

  16. Miniature circulatory systems: A new exposure system for ecotoxicological effect assessments in riverine organisms.

    Science.gov (United States)

    Feiner, Mona; Beggel, Sebastian; Geist, Juergen

    2016-11-01

    Long-term effect assessments in ecotoxicological investigations are important, yet there is a lack of suitable exposure systems for these experiments that can be used for riverine species. A cost-efficient miniature circulatory system was developed that was evaluated for its applicability in long-term exposures in 2 stream-dwelling species: brown trout (Salmo trutta) and an amphipod (Gammarus roeseli). In an egg-to-fry exposure of S. trutta, the toxicity of 2 reverse osmosis concentrates was investigated as examples. Control hatching rate of yolk sac fry was 75 ± 7% and thus complies with the Organisation for Economic Co-operation and Development validity criterion (≥66%). The reverse osmosis concentrates did not impair the hatching rate in any tested concentration. In G. roeseli, mortality rates remained below 20% during a 21-d cultivation, fulfilling the common validity criterion in ecotoxicological testing. Mortality was significantly lower when the species was fed with conditioned alder leaves instead of an artificial shrimp food. Finally, a toxicity test on G. roeseli using copper as the test substance revealed median lethal concentration (LC50) values of 156 μg/L after 96 h and 99 μg/L after 264 h, which is in line with literature findings using other accepted exposure units. In conclusion, the miniature circulatory system provides a novel and cost-efficient exposure system for long-term investigations on riverine species that may also be applicable for other species of fishes and macroinvertebrates. Environ Toxicol Chem 2016;35:2827-2833. © 2016 SETAC. © 2016 SETAC.

  17. Diagnostic-management system and test pulse acquisition for WEST plasma measurement system

    International Nuclear Information System (INIS)

    Wojenski, A.; Kasprowicz, G.; Pozniak, K.T.; Byszuk, A.; Juszczyk, B.; Zabolotny, W.; Zienkiewicz, P.; Chernyshova, M.; Czarski, T.; Mazon, D.; Malard, P.

    2014-01-01

    This paper describes current status of electronic, firmware and software development for new plasma measurement system for use in WEST facility. The system allows to perform two dimensional plasma visualization (in time) with spectrum measurement. The analog front-end is connected to Gas Electron Multiplier detector (GEM detector). The system architecture have high data throughput due to use of PCI-Express interface, Gigabit Transceivers and sampling frequency of ADC integrated circuits. The hardware is based on several years of experience in building X-ray spectrometer system for Joint European Torus (JET) facility. Data streaming is done using Artix7 FPGA devices. The system in basic configuration can work with up to 256 channels, while the maximum number of measurement channels is 2048. Advanced firmware for the FPGA is required in order to perform high speed data streaming and analog signal sampling. Diagnostic system management has been developed in order to configure measurement system, perform necessary calibration and prepare hardware for data acquisition. (authors)

  18. System composition and operation of exposure dose registration and control system (Final report)

    International Nuclear Information System (INIS)

    1978-01-01

    Since November, 1976, the committee concerning the investigation of exposure dose registration and control system for employees in nuclear industries has discussed on the exposure dose registration and control system, issued the interim report (outline) in April, 1977, and continued to investigate the details organizing the working group. Here, the final report is presented. It describes first on the definition of the terms used and the basic concept of the exposure dose registration and control system, in which the name of that organization is decided as ''Central Registration Office for Radiation Works'', Radiation Influence Association, the foundational juridical person. Next, the works to be performed in the Center and nuclear energy enterprises are explained. The items concerning the business management at the time of practical execution are the major part of the report, and are over 22 items. These include the registration business, the official reporting business, inquiry and answer business about career, change and revision, and computer processing system. As the temporary measures for transfer ring to the new system, 10 items are also provided. Supplementary explanation of 9 important items is given in the appendix. (Wakatsuki, Y.)

  19. High-power microwave transmission and launching systems for fusion plasma heating systems

    International Nuclear Information System (INIS)

    Bigelow, T.S.

    1989-01-01

    Microwave power in the 30- to 300-GHz frequency range is becoming widely used for heating of plasma in present-day fusion energy magnetic confinement experiments. Microwave power is effective in ionizing plasma and heating electrons through the electron cyclotron heating (ECH) process. Since the power is absorbed in regions of the magnetic field where resonance occurs and launching antennas with narrow beam widths are possible, power deposition location can be highly controlled. This is important for maximizing the power utilization efficiency and improving plasma parameters. Development of the gyrotron oscillator tube has advanced in recent years so that a 1-MW continuous-wave, 140-GHz power source will soon be available. Gyrotron output power is typically in a circular waveguide propagating a circular electric mode (such as TE 0,2 ) or a whispering-gallery mode (such as TE 15,2 ), depending on frequency and power level. An alternative high-power microwave source currently under development is the free-electron laser (FEL), which may be capable of generating 2-10 MW of average power at frequencies of up to 500 GHz. The FEL has a rectangular output waveguide carrying the TE 0,1 mode. Because of its higher complexity and cost, the high-average-power FEL is not yet as extensively developed as the gyrotron. In this paper, several types of operating ECH transmission systems are discussed, as well systems currently being developed. The trend in this area is toward higher power and frequency due to the improvements in plasma density and temperature possible. Every system requires a variety of components, such as mode converters, waveguide bends, launchers, and directional couplers. Some of these components are discussed here, along with ongoing work to improve their performance. 8 refs

  20. Development of Langmuir probe diagnostic system for 13.56 MHz plasma sources

    International Nuclear Information System (INIS)

    Ranjini, K.; Nabhiraj, P.Y.; Mallik, C.; Bhandari, R.K.

    2006-01-01

    A work on development of high brightness ion source has been started recently. Plasma parameters are strongly linked to the brightness of the ion beams produced from the ion sources. A self compensated Langmuir probe and related automation system for the measurement of plasma parameters is developed. This paper describes design of the probe, software, hardware and the results. (author)

  1. The dispersion relation of charge and current compensated relativistic electron beam-plasma system

    International Nuclear Information System (INIS)

    Vrba, P.; Schroetter, J.; Jarosova, P.; Koerbel, S.

    1978-01-01

    The unstable regions of relativistic electron beam-plasma system were determined by analysing the general dispersion relation numerically. The external parameters were varied to ensure more effective instability excitations. The full charge- and current compensation presumptions lead to the new synchronism predictions. The slow space charge wave and slow cyclotron wave of the return current are synchronous with the plasma ion wave. (author)

  2. Design of next step tokamak: Consistent analysis of plasma performance flux composition and poloidal field system

    International Nuclear Information System (INIS)

    Ane, J.M.; Grandgirard, V.; Albajar, F.; Johner, J.

    2001-01-01

    A consistent and simple approach to derive plasma scenarios for next step tokamak design is presented. It is based on successive plasma equilibria snapshots from plasma breakdown to end of ramp-down. Temperature and density profiles for each equilibrium are derived from a 2D plasma model. The time interval between two successive equilibria is then computed from the toroidal field magnetic energy balance, the resistive term of which depends on n, T profiles. This approach provides a consistent analysis of plasma performance, flux consumption and PF system, including average voltages waveforms across the PF coils. The plasma model and the Poynting theorem for the toroidal magnetic energy are presented. Application to ITER-FEAT and to M2, a Q=5 machine designed at CEA, are shown. (author)

  3. Development of a Plasma Streaming System for the Mirror Fusion Test Facility

    International Nuclear Information System (INIS)

    Holdsworth, T.; Clark, R.N.; McCotter, R.E.; Rossow, T.L.; Cruz, G.E.

    1979-01-01

    The Plasma Streaming System (PSS) is an essential portion of the Mirror Fusion Test Facility (MFTF), scheduled for completion in October 1981. The PSS will develop a plasma density of at least 2 x 10 12 particles/cm 3 at the MFTF magnet centerline by injecting particles along the field lines. The plasma will have a midplane plasma radius as large as 40 cm with variable plasma particle energy and beam geometry. Minimum amounts of impurities will be injected, with emphasis on minimizing high Z materials. Each of the 60 PSS units will consist of a gun magnet assembly (GMA) and a power supply. Each GMA consists of a plasma streaming gun, a pulse magnet that provides variable beam shaping, and a fast reaction pulse gas valve

  4. Analytic analysis on asymmetrical micro arcing in high plasma potential RF plasma systems

    International Nuclear Information System (INIS)

    Yin, Y; McKenzie, D R; Bilek, M M M

    2006-01-01

    We report experimental and analytical results on asymmetrical micro arcing in a RF (radio frequency) plasma. Micro arcing, resulting from high plasma potential, in RF plasma was found to occur only on the grounded electrode for a variety of electrode and surface configurations. The analytic derivation was based on a simple RF time-dependent Child-Langmuir sheath model and electric current continuity. We found that the minimum potential difference in one RF period across the grounded electrode sheath depends on the area ratio of the grounded electrode to the powered electrode. As the area ratio increases, the minimum potential difference across a sheath increases for the grounded electrode but not for the RF powered electrode. We showed that discharge time in micro arcing is more than 100 RF periods; thus the presence of a continuous high electric field in one RF cycle results in micro arcing on the grounded electrode. However, the minimum potential difference in one RF period across the powered electrode sheath is always small so that it prevents micro arcing occurring even though the average sheath voltage can be large. This simple analytic model is consistent with particle-in-cell simulation results

  5. Machine and plasma diagnostic instrumentation systems for the Tandem Mirror Experiment Upgrade

    International Nuclear Information System (INIS)

    Coutts, G.W.; Coffield, F.E.; Lang, D.D.; Hornady, R.S.

    1981-01-01

    To evaluate performance of a second generation Tandem Mirror Machine, an extensive instrumentation system is being designed and installed as part of the major device fabrication. The systems listed will be operational during the start-up phase of the TMX Upgrade machine and provide bench marks for future performance data. In addition to plasma diagnostic instrumentation, machine parameter monitoring systems will be installed prior to machine operation. Simultaneous recording of machine parameters will permit evaluation of plasma parameters sensitive to machine conditions

  6. Prenatal Alcohol Exposure Damages Brain Signal Transduction Systems

    National Research Council Canada - National Science Library

    Caldwell, Kevin

    2001-01-01

    This report details our progress during the first year of a three-year proposal. The proposal's overall goal is to uncover biochemical mechanisms that underlie learning and memory deficits resulting from fetal alcohol exposure (FAE...

  7. Plasma phenomenology in astrophysical systems: Radio-sources and jets

    International Nuclear Information System (INIS)

    Montani, Giovanni; Petitta, Jacopo

    2014-01-01

    We review the plasma phenomenology in the astrophysical sources which show appreciable radio emissions, namely Radio-Jets from Pulsars, Microquasars, Quasars, and Radio-Active Galaxies. A description of their basic features is presented, then we discuss in some details the links between their morphology and the mechanisms that lead to the different radio-emissions, investigating especially the role played by the plasma configurations surrounding compact objects (Neutron Stars, Black Holes). For the sake of completeness, we briefly mention observational techniques and detectors, whose structure set them apart from other astrophysical instruments. The fundamental ideas concerning angular momentum transport across plasma accretion disks—together with the disk-source-jet coupling problem—are discussed, by stressing their successes and their shortcomings. An alternative scenario is then inferred, based on a parallelism between astrophysical and laboratory plasma configurations, where small-scale structures can be found. We will focus our attention on the morphology of the radio-jets, on their coupling with the accretion disks and on the possible triggering phenomena, viewed as profiles of plasma instabilities

  8. Plasma properties of RF magnetron sputtering system using Zn target

    Energy Technology Data Exchange (ETDEWEB)

    Nafarizal, N.; Andreas Albert, A. R.; Sharifah Amirah, A. S.; Salwa, O.; Riyaz Ahmad, M. A. [Microelectronic and Nanotechnology - Shamsuddin Research Centre (MiNT-SRC), Faculty of Electrical and Electronic Engineering, Universiti Tun Hussein Onn Malaysia 86400 Parit Raja, Batu Pahat, Johor (Malaysia)

    2012-06-29

    In the present work, we investigate the fundamental properties of magnetron sputtering plasma using Zn target and its deposited Zn thin film. The magnetron sputtering plasma was produced using radio frequency (RF) power supply and Argon (Ar) as ambient gas. A Langmuir probe was used to collect the current from the plasma and from the current intensity, we calculate the electron density and electron temperature. The properties of Zn sputtering plasma at various discharge conditions were studied. At the RF power ranging from 20 to 100 W and gas pressure 5 mTorr, we found that the electron temperature was almost unchanged between 2-2.5 eV. On the other hand, the electron temperature increased drastically from 6 Multiplication-Sign 10{sup 9} to 1 Multiplication-Sign 10{sup 10}cm{sup -3} when the discharge gas pressure increased from 5 to 10 mTorr. The electron microscope images show that the grain size of Zn thin film increase when the discharge power is increased. This may be due to the enhancement of plasma density and sputtered Zn density.

  9. Prenatal cannabis exposure - The "first hit" to the endocannabinoid system.

    Science.gov (United States)

    Richardson, Kimberlei A; Hester, Allison K; McLemore, Gabrielle L

    As more states and countries legalize medical and/or adult recreational marijuana use, the incidences of prenatal cannabis exposure (PCE) will likely increase. While young people increasingly view marijuana as innocuous, marijuana preparations have been growing in potency in recent years, potentially creating global clinical, public health, and workforce concerns. Unlike fetal alcohol spectrum disorder, there is no phenotypic syndrome associated with PCE. There is also no preponderance of evidence that PCE causes lifelong cognitive, behavioral, or functional abnormalities, and/or susceptibility to subsequent addiction. However, there is compelling circumstantial evidence, based on the principles of teratology and fetal malprogramming, suggesting that pregnant women should refrain from smoking marijuana. The usage of marijuana during pregnancy perturbs the fetal endogenous cannabinoid signaling system (ECSS), which is present and active from the early embryonic stage, modulating neurodevelopment and continuing this role into adulthood. The ECSS is present in virtually every brain structure and organ system, and there is also evidence that this system is important in the regulation of cardiovascular processes. Endocannabinoids (eCBs) undergird a broad spectrum of processes, including the early stages of fetal neurodevelopment and uterine implantation. Delta-9-tetrahydrocannabinol (THC), the psychoactive chemical in cannabis, enters maternal circulation, and readily crosses the placental membrane. THC binds to CB receptors of the fetal ECSS, altering neurodevelopment and possibly rewiring ECSS circuitry. In this review, we discuss the Double-Hit Hypothesis as it relates to PCE. We contend that PCE, similar to a neurodevelopmental teratogen, delivers the first hit to the ECSS, which is compromised in such a way that a second hit (i.e., postnatal stressors) will precipitate the emergence of a specific phenotype. In summary, we conclude that perturbations of the

  10. Enhancement of Wound Healing by Non-Thermal N2/Ar Micro-Plasma Exposure in Mice with Fractional-CO2-Laser-Induced Wounds

    Science.gov (United States)

    Shao, Pei-Lin; Liao, Jiunn-Der; Wong, Tak-Wah; Wang, Yi-Cheng; Leu, Steve; Yip, Hon-Kan

    2016-01-01

    Micro-plasma is a possible alternative treatment for wound management. The effect of micro-plasma on wound healing depends on its composition and temperature. The authors previously developed a capillary-tube-based micro-plasma system that can generate micro-plasma with a high nitric oxide-containing species composition and mild working temperature. Here, the efficacy of micro-plasma treatment on wound healing in a laser-induced skin wound mouse model was investigated. A partial thickness wound was created in the back skin of each mouse and then treated with micro-plasma. Non-invasive methods, namely wound closure kinetics, optical coherence tomography (OCT), and laser Doppler scanning, were used to measure the healing efficiency in the wound area. Neo-tissue growth and the expressions of matrix metallopeptidase-3 (MMP-3) and laminin in the wound area were assessed using histological and immunohistochemistry (IHC) analysis. The results show that micro-plasma treatment promoted wound healing. Micro-plasma treatment significantly reduced the wound bed region. The OCT images and histological analysis indicates more pronounced tissue regrowth in the wound bed region after micro-plasma treatment. The laser Doppler images shows that micro-plasma treatment promoted blood flow in the wound bed region. The IHC results show that the level of laminin increased in the wound bed region after micro-plasma treatment, whereas the level of MMP-3 decreased. Based on these results, micro-plasma has potential to be used to promote the healing of skin wounds clinically. PMID:27248979

  11. Advanced antenna system for Alfven wave plasma heating and current drive in TCABR tokamak

    International Nuclear Information System (INIS)

    Ruchko, L.F.; Ozono, E.; Galvao, R.M.O.; Nascimento, I.C.; Degasperi, F.T.; Lerche, E.

    1998-01-01

    An advanced antenna system that has been developed for investigation of Alfven wave plasma heating and current drive in the TCABR tokamak is described. The main goal was the development of such a system that could insure the excitation of travelling single helicity modes with predefined wave mode numbers M and N. The system consists of four similar modules with poloidal windings. The required spatial spectrum is formed by proper phasing of the RF feeding currents. The impedance matching of the antenna with the four-phase oscillator is accomplished by resonant circuits which form one assembly unit with the RF feeders. The characteristics of the antenna system design with respect to the antenna-plasma coupling and plasma wave excitation, for different phasing of the feeding currents, are summarised. The antenna complex impedance Z=Z R +Z I is calculated taking into account both the plasma response to resonant excitation of fast Alfven waves and the nonresonant excitation of vacuum magnetic fields in conducting shell. The matching of the RF generator with the antenna system during plasma heating is simulated numerically, modelling the plasma response with mutually coupled effective inductances with corresponding active Z R and reactive Z I impedances. The results of the numerical simulation of the RF system performance, including both the RF magnetic field spectrum analysis and the modeling of the RF generator operation with plasma load, are presented. (orig.)

  12. Multi-walled carbon nanotube-physicochemical properties predict the systemic acute phase response following pulmonary exposure in mice.

    Directory of Open Access Journals (Sweden)

    Sarah S Poulsen

    Full Text Available Pulmonary exposure to multi-walled carbon nanotubes (MWCNTs has been linked to an increased risk of developing cardiovascular disease in addition to the well-documented physicochemical-dependent adverse lung effects. A proposed mechanism is through a strong and sustained pulmonary secretion of acute phase proteins to the blood. We identified physicochemical determinants of MWCNT-induced systemic acute phase response by analyzing effects of pulmonary exposure to 14 commercial, well-characterized MWCNTs in female C57BL/6J mice pulmonary exposed to 0, 6, 18 or 54 μg MWCNT/mouse. Plasma levels of acute phase response proteins serum amyloid A1/2 (SAA1/2 and SAA3 were determined on day 1, 28 or 92. Expression levels of hepatic Saa1 and pulmonary Saa3 mRNA levels were assessed to determine the origin of the acute phase response proteins. Pulmonary Saa3 mRNA expression levels were greater and lasted longer than hepatic Saa1 mRNA expression. Plasma SAA1/2 and SAA3 protein levels were related to time and physicochemical properties using adjusted, multiple regression analyses. SAA3 and SAA1/2 plasma protein levels were increased after exposure to almost all of the MWCNTs on day 1, whereas limited changes were observed on day 28 and 92. SAA1/2 and SAA3 protein levels did not correlate and only SAA3 protein levels correlated with neutrophil influx. The multiple regression analyses revealed a protective effect of MWCNT length on SAA1/2 protein level on day 1, such that a longer length resulted in lowered SAA1/2 plasma levels. Increased SAA3 protein levels were positively related to dose and content of Mn, Mg and Co on day 1, whereas oxidation and diameter of the MWCNTs were protective on day 28 and 92, respectively. The results of this study reveal very differently controlled pulmonary and hepatic acute phase responses after MWCNT exposure. As the responses were influenced by the physicochemical properties of the MWCNTs, this study provides the first step

  13. Exploratory Study of Total and Free Prednisolone Plasma Exposure and Cushingoid Appearance, Quality of Life and Biochemical Toxicity in Adult Male Kidney Transplant Recipients

    DEFF Research Database (Denmark)

    Bergmann, Troels K; Isbel, Nicole M; Ostini, Remo

    2015-01-01

    relationships between prednisolone exposure and adverse effects. METHODS: Male kidney transplant recipients were recruited for serial blood sampling and assessment of glucocorticoid-related adverse effects including dyslipidaemia, abnormal body fat distribution, Cushingoid appearance and impaired quality...... of life. Total and free prednisolone plasma concentrations were determined using ultra-high-performance liquid chromatography with tandem mass spectrometric detection. Prednisolone exposure was estimated using a limited sampling strategy. RESULTS: Fifty-six patients were recruited. Patients had a mean age...... of 54 years and median time post-transplantation of 75 months. Median prednisolone dose was 5 mg. Mean area under the plasma concentration-time curve was 2390 nmol h/L (±580) (SD) and 175 nmol h/L (±78) for total and free prednisolone, respectively. Waist to upper arm circumference ratio was positively...

  14. Analysis of Cigarette Smoke Deposition Within an In Vitro Exposure System for Simulating Exposure in the Human Respiratory Tract

    Directory of Open Access Journals (Sweden)

    Ishikawa Shinkichi

    2016-01-01

    Full Text Available For the risk assessment of airborne chemicals, a variety of in vitro direct exposure systems have been developed to replicate airborne chemical exposure in vivo. Since cells at the air-liquid interface are exposed to cigarette smoke as an aerosol in direct exposure systems, it is possible to reproduce the situation of cigarette smoke exposure in the human respiratory system using this device. However it is difficult to know whether the exposed cigarette smoke in this system is consistent with the smoke retained in the human respiratory tract. The purpose of this study is to clarify this point using the CULTEX® RFS module which is a recently developed direct exposure system. For this purpose, solanesol and acetaldehyde were respectively chosen as the particulate and gas/vapor phase representatives of smoke constituents, and their deposition and balance per unit area of cell culture surface of the RFS module were measured (dosimetry. We also conducted human retention studies to compare with the dosimetry data. By comparing inhaled smoke and exhaled smoke under three inhalation conditions, we estimated the regional retention and balance of each representative per unit surface area of the respiratory tract (mouth, bronchi, and alveoli separately. The deposition of solanesol and acetaldehyde per unit area of cell culture surface in the RFS module decreased dependent on the dilution flow rate and ranged from 0.26-0.0076%/cm2 in our experimental conditions. The ratio of deposited acetaldehyde to deposited solanesol ranged from 0.96-1.96 in the RFS module. The retention of solanesol and acetaldehyde per unit surface area in the mouth and the bronchi ranged from 0.095-0.0083%/cm2 in this study. The retention per unit surface area of alveoli was far lower than in the other two regions (0.0000063%/cm2. The ratio of retained acetaldehyde to retained solanesol ranged from 0.54-1.97. From these results, we concluded that the CULTEX® RFS module can simulate

  15. Some preliminary views of plasma interaction: electromagnetic-launch systems

    International Nuclear Information System (INIS)

    Buckingham, A.C.; Hawke, R.S.

    1982-01-01

    This discussion outlines a few areas of fundamental research which appear vital for progress in developing advanced propulsion concepts using dc railgun thrusters. We have placed emphasis on the following: (1) dense plasma and high current density influences on changes in microstructure and properties of conventional rail conductors such as Cu, Al, and W alloys or composites; (2) the influences described in (1) on more advanced high temperature, microstrain resistant, materials such as amorphous tungsten; (3) location, description and temporal evolution of current, magnetic field, and losses during intense plasma-current field interactions with conductors; and (4) composite materials and sequentially sectioned structures for more efficient EM dc launcher configuration

  16. Proceedings of the international symposium on environmental technologies: Plasma systems and applications. Volume 1

    International Nuclear Information System (INIS)

    Mayne, P.W.; Mulholland, J.A.

    1995-01-01

    Plasma technology is an extremely versatile and powerful means of obtaining very high temperatures that can be used in a variety of environmental situations. Since most types of waste products and contaminants can be treated effectively and efficiently, plasma systems have been developed to address the disposal and annihilation domestic of medical, hazardous, radioactive, military, and miscellaneous wastes. Plasma technologies can also be implemented to recycle and recover usable materials from metallic wastes. The International Symposium on Environmental Technologies: Plasma Systems and Applications was held at the Omni Hotel in Atlanta, Georgia on October 8--12, 1995 to bring together a large group of technical experts working on the use of plasma for solving environmental problems. The Symposium is a sequel to the 1994 Metatechnies Conference on Stabilization and Volarization of Ultimate Waste by Plasma Processes that was held in September of 1994 at Bordeaux Lac, France. The proceedings to this second international conference contain the written contributions from eleven sessions and are published in two volumes. A total of 65 papers address the use of plasma systems for environmental applications and include topics concerning the development and use of innovative technologies for waste treatment, environmental remediation, recycling, characterization of the plasma and solid residue, off-gas analyses, as well as case studies and regulatory policies

  17. Microwave remote plasma enhanced-atomic layer deposition system with multicusp confinement chamber.

    Science.gov (United States)

    Dechana, A; Thamboon, P; Boonyawan, D

    2014-10-01

    A microwave remote Plasma Enhanced-Atomic Layer Deposition system with multicusp confinement chamber is established at the Plasma and Beam Physics research facilities, Chiang Mai, Thailand. The system produces highly-reactive plasma species in order to enhance the deposition process of thin films. The addition of the multicusp magnetic fields further improves the plasma density and uniformity in the reaction chamber. Thus, the system is more favorable to temperature-sensitive substrates when heating becomes unwanted. Furthermore, the remote-plasma feature, which is generated via microwave power source, offers tunability of the plasma properties separately from the process. As a result, the system provides high flexibility in choice of materials and design experiments, particularly for low-temperature applications. Performance evaluations of the system were carried on coating experiments of Al2O3 layers onto a silicon wafer. The plasma characteristics in the chamber will be described. The resulted Al2O3 films-analyzed by Rutherford Backscattering Spectrometry in channeling mode and by X-ray Photoelectron Spectroscopy techniques-will be discussed.

  18. Microwave remote plasma enhanced-atomic layer deposition system with multicusp confinement chamber

    Energy Technology Data Exchange (ETDEWEB)

    Dechana, A. [Program of Physics and General Science, Faculty of Science and Technology, Songkhla Rajabhat University, Songkhla 90000 (Thailand); Thamboon, P. [Science and Technology Research Institute, Chiang Mai University, Chiang Mai 50200 (Thailand); Boonyawan, D., E-mail: dheerawan.b@cmu.ac.th [Plasma and Beam Physics Research Facility, Department of Physics and Materials Science, Faculty of Science, Chiang Mai University, Chiang Mai 50200 (Thailand)

    2014-10-15

    A microwave remote Plasma Enhanced-Atomic Layer Deposition system with multicusp confinement chamber is established at the Plasma and Beam Physics research facilities, Chiang Mai, Thailand. The system produces highly-reactive plasma species in order to enhance the deposition process of thin films. The addition of the multicusp magnetic fields further improves the plasma density and uniformity in the reaction chamber. Thus, the system is more favorable to temperature-sensitive substrates when heating becomes unwanted. Furthermore, the remote-plasma feature, which is generated via microwave power source, offers tunability of the plasma properties separately from the process. As a result, the system provides high flexibility in choice of materials and design experiments, particularly for low-temperature applications. Performance evaluations of the system were carried on coating experiments of Al{sub 2}O{sub 3} layers onto a silicon wafer. The plasma characteristics in the chamber will be described. The resulted Al{sub 2}O{sub 3} films—analyzed by Rutherford Backscattering Spectrometry in channeling mode and by X-ray Photoelectron Spectroscopy techniques—will be discussed.

  19. Microwave remote plasma enhanced-atomic layer deposition system with multicusp confinement chamber

    Science.gov (United States)

    Dechana, A.; Thamboon, P.; Boonyawan, D.

    2014-10-01

    A microwave remote Plasma Enhanced-Atomic Layer Deposition system with multicusp confinement chamber is established at the Plasma and Beam Physics research facilities, Chiang Mai, Thailand. The system produces highly-reactive plasma species in order to enhance the deposition process of thin films. The addition of the multicusp magnetic fields further improves the plasma density and uniformity in the reaction chamber. Thus, the system is more favorable to temperature-sensitive substrates when heating becomes unwanted. Furthermore, the remote-plasma feature, which is generated via microwave power source, offers tunability of the plasma properties separately from the process. As a result, the system provides high flexibility in choice of materials and design experiments, particularly for low-temperature applications. Performance evaluations of the system were carried on coating experiments of Al2O3 layers onto a silicon wafer. The plasma characteristics in the chamber will be described. The resulted Al2O3 films—analyzed by Rutherford Backscattering Spectrometry in channeling mode and by X-ray Photoelectron Spectroscopy techniques—will be discussed.

  20. Microwave remote plasma enhanced-atomic layer deposition system with multicusp confinement chamber

    International Nuclear Information System (INIS)

    Dechana, A.; Thamboon, P.; Boonyawan, D.

    2014-01-01

    A microwave remote Plasma Enhanced-Atomic Layer Deposition system with multicusp confinement chamber is established at the Plasma and Beam Physics research facilities, Chiang Mai, Thailand. The system produces highly-reactive plasma species in order to enhance the deposition process of thin films. The addition of the multicusp magnetic fields further improves the plasma density and uniformity in the reaction chamber. Thus, the system is more favorable to temperature-sensitive substrates when heating becomes unwanted. Furthermore, the remote-plasma feature, which is generated via microwave power source, offers tunability of the plasma properties separately from the process. As a result, the system provides high flexibility in choice of materials and design experiments, particularly for low-temperature applications. Performance evaluations of the system were carried on coating experiments of Al 2 O 3 layers onto a silicon wafer. The plasma characteristics in the chamber will be described. The resulted Al 2 O 3 films—analyzed by Rutherford Backscattering Spectrometry in channeling mode and by X-ray Photoelectron Spectroscopy techniques—will be discussed

  1. Combustion flame-plasma hybrid reactor systems, and chemical reactant sources

    Science.gov (United States)

    Kong, Peter C

    2013-11-26

    Combustion flame-plasma hybrid reactor systems, chemical reactant sources, and related methods are disclosed. In one embodiment, a combustion flame-plasma hybrid reactor system comprising a reaction chamber, a combustion torch positioned to direct a flame into the reaction chamber, and one or more reactant feed assemblies configured to electrically energize at least one electrically conductive solid reactant structure to form a plasma and feed each electrically conductive solid reactant structure into the plasma to form at least one product is disclosed. In an additional embodiment, a chemical reactant source for a combustion flame-plasma hybrid reactor comprising an elongated electrically conductive reactant structure consisting essentially of at least one chemical reactant is disclosed. In further embodiments, methods of forming a chemical reactant source and methods of chemically converting at least one reactant into at least one product are disclosed.

  2. Human circulating plasma DNA significantly decreases while lymphocyte DNA damage increases under chronic occupational exposure to low-dose gamma-neutron and tritium β-radiation

    Energy Technology Data Exchange (ETDEWEB)

    Korzeneva, Inna B., E-mail: inna.korzeneva@molgen.vniief.ru [Russian Federal Nuclear Center – All-Russian Research Institute of Experimental Physics (RFNC-VNIIEF) 607190, Sarov, 37 Mira ave., Nizhniy Novgorod Region (Russian Federation); Kostuyk, Svetlana V.; Ershova, Liza S. [Research Centre for Medical Genetics, Russian Academy of Medical Sciences, 115478 Moscow, 1 Moskvorechye str. (Russian Federation); Osipov, Andrian N. [Federal Medial and Biological Center named after Burnazyan of the Federal Medical and Biological Agency (FMBTz named after Burnazyan of FMBA), Moscow (Russian Federation); State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Zhivopisnaya, 46, Moscow, 123098 (Russian Federation); Zhuravleva, Veronika F.; Pankratova, Galina V. [Russian Federal Nuclear Center – All-Russian Research Institute of Experimental Physics (RFNC-VNIIEF) 607190, Sarov, 37 Mira ave., Nizhniy Novgorod Region (Russian Federation); Porokhovnik, Lev N.; Veiko, Natalia N. [Research Centre for Medical Genetics, Russian Academy of Medical Sciences, 115478 Moscow, 1 Moskvorechye str. (Russian Federation)

    2015-09-15

    Highlights: • The chronic exposure to low-dose IR induces DSBs in human lymphocytes (TM index). • Exposure to IR decreases the level of human circulating DNA (cfDNA index). • IR induces an increase of DNase1 activity (DNase1 index) in plasma. • IR induces an increase of the level of antibodies to DNA (Ab DNA index) in plasma. • The ratio cfDNA/(DNase 1 × Ab DNA × TM) is a potential marker of human exposure to IR. - Abstract: The blood plasma of healthy people contains cell-fee (circulating) DNA (cfDNA). Apoptotic cells are the main source of the cfDNA. The cfDNA concentration increases in case of the organism’s cell death rate increase, for example in case of exposure to high-dose ionizing radiation (IR). The objects of the present research are the blood plasma and blood lymphocytes of people, who contacted occupationally with the sources of external gamma/neutron radiation or internal β-radiation of tritium N = 176). As the controls (references), blood samples of people, who had never been occupationally subjected to the IR sources, were used (N = 109). With respect to the plasma samples of each donor there were defined: the cfDNA concentration (the cfDNA index), DNase1 activity (the DNase1 index) and titre of antibodies to DNA (the Ab DNA index). The general DNA damage in the cells was defined (using the Comet assay, the tail moment (TM) index). A chronic effect of the low-dose ionizing radiation on a human being is accompanied by the enhancement of the DNA damage in lymphocytes along with a considerable cfDNA content reduction, while the DNase1 content and concentration of antibodies to DNA (Ab DNA) increase. All the aforementioned changes were also observed in people, who had not worked with the IR sources for more than a year. The ratio cfDNA/(DNase1 × Ab DNA × TM) is proposed to be used as a marker of the chronic exposure of a person to the external low-dose IR. It was formulated the assumption that the joint analysis of the cfDNA, DNase1, Ab

  3. Prenatal cigarette smoke exposure: Pregnancy outcome and gestational changes in plasma nicotine concentration, hematocrit, and carboxyhemoglobin in a newly standardized rat model

    International Nuclear Information System (INIS)

    Farkas, Svetlana; Hussein, Jabeen; Ariano, Robert E.; Sitar, Daniel S.; Hasan, Shabih U.

    2006-01-01

    Epidemiological studies support an association between perinatal cigarette smoke (CS) exposure and a number of severe pre- and postnatal complications. However, the mechanisms through which CS enhances such risks largely remain unknown. One of the reasons for our inability to discover such mechanisms has been the unavailability of a clinically relevant and physiologically concordant animal model. A number of studies have previously used nicotine (Nic) as surrogate for CS. We sought to (1) establish the amount of CS exposure to achieve plasma Nic concentrations observed among moderate to heavy smokers (20-60 ng/ml) (2) investigate the temporal changes in plasma Nic concentrations, carboxyhemoglobin, and hematocrit with advancing pregnancy, and (3) elucidate the effects of CS exposure on pregnancy outcome. Pregnant Sprague-Dawley rats were exposed to various doses of CS or room air (Sham) from days 6 to 21 of gestation. Exposure to 6000 ml/day of CS led to very high plasma Nic concentrations and increased maternal and fetal mortality (P < 0.001). The plasma Nic concentrations remained higher than those observed in moderate smokers until the CS dose was reduced to 1000 ml/day and showed dose-dependent temporal changes with advancing gestational age. Significant increases in carboxyhemoglobin and hematocrit were observed in the CS group as compared with the Sham group (P < 0.001). In addition, prenatally CS exposed fetuses had lower birth weight as compared with the Sham group (P = 0.04). Our current study establishes a newly standardized and physiologically relevant model to investigate the mechanisms of CS-mediated adverse effects during the critical period of fetal development

  4. Inhibition of P-glycoprotein and multidrug resistance-associated protein 2 regulates the hepatobiliary excretion and plasma exposure of thienorphine and its glucuronide conjugate

    Directory of Open Access Journals (Sweden)

    Ling-Lei Kong

    2016-08-01

    Full Text Available Thienorphine (TNP is a novel partial opioid agonist that has completed phase II clinical evaluation as a promising drug candidate for the treatment of opioid dependence. Previous studies have shown that TNP and its glucuronide conjugate (TNP-G undergo significant bile excretion. The purpose of this study was to investigate the roles of efflux transporters in regulating biliary excretion and plasma exposure of TNP and TNP-G. An ATPase assay suggested that TNP and TNP-G were substrates of P-gp and MRP2, respectively. The in vitro data from rat hepatocytes showed that bile excretion of TNP and TNP-G was regulated by the P-gp and MRP2 modulators. The accumulation of TNP and TNP-G in HepG2 cells significantly increased by the treatment of mdr1a or MRP2 siRNA for P-gp or MRP2 modulation. In intact rats, the bile excretion and pharmacokinetic profiles of TNP and TNP-G were remarkably changed with tariquidar and probenecid pretreatment, respectively. Tariquidar increased the Cmax and AUC0-t and decreased MRT and T1/2 of TNP, whereas probenecid decreased the plasma exposure of TNP-G and increased its T1/2. Knockdown P-gp and MRP2 function using siRNA significantly increased the plasma exposure of TNP and TNP-G and reduced their mean retention time in mice. These results indicated the important roles of P-gp and MRP2 in hepatobiliary excretion and plasma exposure of TNP and TNP-G. Inhibition of the efflux transporters may affect the pharmacokinetics of TNP and result in a drug-drug interaction between TNP and the concomitant transporter inhibitor or inducer in clinic.

  5. Return-current formation in the electron beam - plasma system

    Czech Academy of Sciences Publication Activity Database

    Karlický, Marian; Bárta, Miroslav

    2009-01-01

    Roč. 16, č. 4 (2009), s. 525-532 ISSN 1023-5809 R&D Projects: GA AV ČR IAA300030701 Institutional research plan: CEZ:AV0Z10030501 Keywords : solar flares * plasma instabilities * numerical simulations Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics Impact factor: 1.152, year: 2009

  6. Real time control of plasmas and ECRH systems on TCV

    NARCIS (Netherlands)

    Paley, J.I.; Felici, F.; Berrino, J.; Coda, S.; Cruz, N.; Duval, B.P.; Goodman, T.P.; Martin, Y.; Moret, J.-M.; Piras, F.; Rodrigues, A.P.; Santos, B.; Varandas, C.A.F.

    2008-01-01

    Developments in the real time control hardware on TCV paired with the flexibility of plasma shaping and ECRH actuators are opening many opportunities to perform real time experiments and develop algorithms and methods for fusion applications. The ability to control MHD instabilities is particularly

  7. Real time control of plasmas and ECRH systems on TCV

    NARCIS (Netherlands)

    Paley, J.I.; Berrino, J.; Coda, S.; Cruz, N.; Duval, B.P.; Felici, F.; Goodman, T.P.; Martin, Y.; Moret, J.-M.; Piras, F.; Rodriques, A.P.; Santos, B.; Varandas, C.A.F.

    2009-01-01

    Developments in the real time control hardware on Tokamak Configuration Variable (TCV) coupled with the flexibility of plasma shaping and electron cyclotron (EC) heating and current drive actuators are opening many opportunities to perform real time experiments and develop algorithms and methods for

  8. Characterization of a segmented plasma torch assisted High Heat Flux (HHF) system for performance evaluation of plasma facing components in fusion devices

    International Nuclear Information System (INIS)

    Ngangom, Aomoa; Sarmah, Trinayan; Sah, Puspa; Kakati, Mayur; Ghosh, Joydeep

    2015-01-01

    A wide variety of high heat and particle flux test facilities are being used by the fusion community to evaluate the thermal performance of plasma facing materials/components, which includes electron beam, ion beam, neutral beam and thermal plasma assisted sources. In addition to simulate heat loads, plasma sources have the additional advantage of reproducing exact fusion plasma like conditions, in terms of plasma density, temperature and particle flux. At CPP-IPR, Assam, we have developed a high heat and particle flux facility using a DC, non-transferred, segmented thermal plasma torch system, which can produce a constricted, stabilized plasma jet with high ion density. In this system, the plasma torch exhausts into a low pressure chamber containing the materials to be irradiated, which produces an expanded plasma jet with more uniform profiles, compared to plasma torches operated at atmospheric pressure. The heat flux of the plasma beam was studied by using circular calorimeters of different diameters (2 and 3 cm) for different input power (5-55 kW). The effect of the change in gas (argon) flow rate and mixing of gases (argon + hydrogen) was also studied. The heat profile of the plasma beam was also studied by using a pipe calorimeter. From this, the radial heat flux was calculated by using Abel inversion. It is seen that the required heat flux of 10 MW/m 2 is achievable in our system for pure argon plasma as well as for plasma with gas mixtures. The plasma parameters like the temperature, density and the beam velocity were studied by using optical emission spectroscopy. For this, a McPherson made 1.33 meter focal length spectrometer; model number 209, was used. A plane grating with 1800 g/mm was used which gave a spectral resolution of 0.007 nm. A detailed characterization with respect to these plasma parameters for different gas (argon) flow rate and mixing of gases (argon+hydrogen) for different input power will be presented in this paper. The plasma

  9. Edge plasma diagnostics in the compact helical system (CHS) device using fast neutral lithium beam

    Energy Technology Data Exchange (ETDEWEB)

    Ueda, Mario

    1992-05-01

    This paper reports the research activities of the author on using fast neutral lithium beam edge plasma diagnostic, at the Japanese National Institute for Fusion Science compact helical system (CHS). (author). 20 figs.

  10. Chemistry and Properties of Slags from Navy Solid Waste Destruction in the Plasma Arc System

    National Research Council Canada - National Science Library

    Talmy, Inna

    1999-01-01

    The U.S. Navy is currently developing a highly efficient shipboard system which employs a plasma torch to process Navy solid wastes primarily consisting of cardboard, paper, steel, aluminum, glass, and food waste...

  11. Overview of the preliminary design of the ITER plasma control system

    Science.gov (United States)

    Snipes, J. A.; Albanese, R.; Ambrosino, G.; Ambrosino, R.; Amoskov, V.; Blanken, T. C.; Bremond, S.; Cinque, M.; de Tommasi, G.; de Vries, P. C.; Eidietis, N.; Felici, F.; Felton, R.; Ferron, J.; Formisano, A.; Gribov, Y.; Hosokawa, M.; Hyatt, A.; Humphreys, D.; Jackson, G.; Kavin, A.; Khayrutdinov, R.; Kim, D.; Kim, S. H.; Konovalov, S.; Lamzin, E.; Lehnen, M.; Lukash, V.; Lomas, P.; Mattei, M.; Mineev, A.; Moreau, P.; Neu, G.; Nouailletas, R.; Pautasso, G.; Pironti, A.; Rapson, C.; Raupp, G.; Ravensbergen, T.; Rimini, F.; Schneider, M.; Travere, J.-M.; Treutterer, W.; Villone, F.; Walker, M.; Welander, A.; Winter, A.; Zabeo, L.

    2017-12-01

    An overview of the preliminary design of the ITER plasma control system (PCS) is described here, which focusses on the needs for 1st plasma and early plasma operation in hydrogen/helium (H/He) up to a plasma current of 15 MA with moderate auxiliary heating power in low confinement mode (L-mode). Candidate control schemes for basic magnetic control, including divertor operation and kinetic control of the electron density with gas puffing and pellet injection, were developed. Commissioning of the auxiliary heating systems is included as well as support functions for stray field topology and real-time plasma boundary reconstruction. Initial exception handling schemes for faults of essential plant systems and for disruption protection were developed. The PCS architecture was also developed to be capable of handling basic control for early commissioning and the advanced control functions that will be needed for future high performance operation. A plasma control simulator is also being developed to test and validate control schemes. To handle the complexity of the ITER PCS, a systems engineering approach has been adopted with the development of a plasma control database to keep track of all control requirements.

  12. Integrated transport code system for a multicomponent plasma in a gas dynamic trap

    International Nuclear Information System (INIS)

    Anikeev, A.V.; Karpushov, A.N.; Noak, K.; Strogalova, S.L.

    2000-01-01

    This report is focused on the development of the theoretical and numerical models of multicomponent high-β plasma confinement and transport in the gas-dynamic trap (GDT). In order to simulate the plasma behavior in the GDT as well as that in the GDT-based neutron source the Integrated Transport Code System is developed from existing stand-alone codes calculating the target plasma, the fast ions and the neutral gas in the GDT. The code system considers the full dependence of the transport phenomena on space, time, energy and angle variables as well as the interactions between the particle fields [ru

  13. Linear quadratic Gaussian controller design for plasma current, position and shape control system in ITER

    International Nuclear Information System (INIS)

    Belyakov, V.; Kavin, A.; Rumyantsev, E.; Kharitonov, V.; Misenov, B.; Ovsyannikov, A.; Ovsyannikov, D.; Veremei, E.; Zhabko, A.; Mitrishkin, Y.

    1999-01-01

    This paper is focused on the linear quadratic Gaussian (LQG) controller synthesis methodology for the ITER plasma current, position and shape control system as well as power derivative management system. It has been shown that some poloidal field (PF) coils have less influence on reference plasma-wall gaps control during plasma disturbances and hence they have been used to reduce total control power derivative by means of the additional non-linear feedback. The design has been done on the basis of linear models. Simulation was provided for non-linear model and results are presented and discussed. (orig.)

  14. Assessment of indirect human exposure to environmental sources of nickel: oral exposure and risk characterization for systemic effects.

    Science.gov (United States)

    De Brouwere, Katleen; Buekers, Jurgen; Cornelis, Christa; Schlekat, Christian E; Oller, Adriana R

    2012-03-01

    This paper describes the indirect human exposure to Ni via the oral route for the regional scale in the EU, together with a method to assess additional local exposure from industrial emissions. The approach fills a gap in the generic REACH guidance which is inadequate for assessing indirect environmental exposure of metals. Estimates of regional scale Ni dietary intake were derived from Ni dietary studies performed in the EU. Typical and Reasonable Worst Case dietary Ni intakes for the general population in the EU were below the oral Derived No Effect Level (DNEL) of Ni sulfate for systemic effects. Estimates for the Ni dietary intake at the local scale take into account the influence of aerial Ni deposition and transfer from soil to crops grown near industrial plants emitting Ni. The additional dietary exposure via this local contribution was small. Despite the use of conservative parameters for these processes, this method may underestimate dietary exposure around older industrial sites because REACH guidance does not account for historical soil contamination. Nevertheless, the method developed here can also be used as a screening tool for community-based risk assessment, as it accounts for historical soil pollution. Nickel exposure via drinking water was derived from databases on Ni tap water quality. A small proportion of the EU population (<5%) is likely to be exposed to tap water exceeding the EU standard (20 μg Ni/l). Taking into account the relative gastrointestinal absorption of Ni from water (30%) versus from solid matrices (5%), water intake constitutes, after dietary intake, the second most important pathway for oral Ni intake. Incidental ingestion of Ni from soil/dust at the regional scale, and also at the local scale, was low in comparison with dietary intake. Copyright © 2011 Elsevier B.V. All rights reserved.

  15. Systemic uptake and clearance of chloroform by hairless rats following dermal exposure. I. Brief exposure to aqueous solutions.

    Science.gov (United States)

    Islam, M S; Zhao, L; Zhou, J; Dong, L; McDougal, J N; Flynn, G L

    1996-06-01

    The systemic uptake of chloroform from dilute aqueous solutions into live hairless rats under conditions simulating dermal environmental exposure was studied. Whole blood was sampled during a 30-min immersion of an animal within water containing a known concentration of chloroform and then for 5.5 h following its removal from the bath. The amount of chloroform systemically absorbed was determined by comparing the AUCs of the blood concentration vs. time plots from dermal exposure to that obtained after i.v. infusion (for a period of 30 min) of an aqueous solution containing a known amount of chloroform (positive control). Although dermal data implied two-compartment disposition characteristics, i.v. infusion data fit best to a three-compartment disposition. Linear pharmacokinetics was observed both by i.v. administration and percutaneous absorption at the dose levels studied. Chloroform was detected in the rat blood as early as 4 min following exposure. Our findings suggest that about 10.2 mg of chloroform was systemically absorbed after dermal exposure of a rat to an aqueous solution of 0.44 mg/ml. This amount is substantially higher than the predictions of mathematical risk-models put forth by some investigators. However, when expressed as the "effective" permeability coefficient (Kpeff), close agreement was noticed between our value and those estimated by others using physiologically based pharmacokinetic (PBPK) models. Also, in terms of Kpeff, reasonable agreement existed between our and another investigator's past estimates of uptake based on depletion of bath level of chloroform and the actual uptake measured in our current experiments. The estimated onset of systemic entry seen here is entirely consistent with our estimate of how long it takes to establish the diffusion gradient across the stratum corneum based on tape stripping.

  16. Blister/hole formation on tungsten surface due to low-energy and high-flux deuterium/helium plasma exposures

    International Nuclear Information System (INIS)

    Nishijima, D.; Iwakiri, H.; Yoshida, N.; Ye, M.Y.; Ohno, N.; Takamura, S.

    2005-01-01

    Deuterium/helium plasma exposures on tungsten surface bring serious damages such as blister and hole. Blistering occurs by cleaving along layered structure intrinsic to the press-roll manufacturing process. Mechanical polishing and helium pre-exposure on mirror-finished powder metallurgy tungsten drastically suppress blister formation. Small cracks made by a polishing would become paths to the surface for diffusing deuterium atoms in the substrate, resulting in no gas accumulation and no blister formation on the surface. Helium pre-exposure would make a helium-enriched layer near the surface, which becomes a kind of diffusion barrier for incident deuterium atoms. Blister formation and deuterium retention are suppressed on the surface with helium-enriched layer. (author)

  17. Results of bench-scale plasma system testing in support of the Plasma Hearth Process

    International Nuclear Information System (INIS)

    Leatherman, G.L.; Cornelison, C.; Frank, S.

    1996-01-01

    The Plasma Hearth Process (PHP) is a high-temperature process that destroys hazardous organic components and stabilizes the radioactive components and hazardous metals in a leach-resistant vitreous slag waste form. The PHP technology development program is targeted at mixed waste that cannot be easily treated by conventional means. For example, heterogeneous debris, which may contain hazardous organics, toxic metals, and radionuclides, is difficult to characterize and cannot be treated with conventional thermal, chemical, or physical treatment methods. A major advantage of the PHP over other plasma processes is its ability to separate nonradioactive, non-hazardous metals from the non-metallic and radioactive components which are contained in the vitreous slag. The overall PHP program involves the design, fabrication, and operation of test hardware to demonstrate and certify that the PHP concept is viable for DOE waste treatment. The program involves bench-scale testing of PHP equipment in radioactive service, as well as pilot-scale demonstration of the PHP concept using nonradioactive, surrogate test materials. The fate of secondary waste streams is an important consideration for any technology considered for processing mixed waste. The main secondary waste stream generated by the PHP is flyash captured by the fabric- filter baghouse. The PHP concept is that flyash generated by the process can, to a large extent, be treated by processing this secondary waste stream in the PHP. Prior to the work presented in the paper, however, the PHP project has not quantitatively demonstrated the ability to treat PHP generated flyash. A major consideration is the quantity of radionuclides and RCRA-regulated metals in the flyash that can be retained the resultant waste form

  18. Plasma control techniques of the ASDEX feedback system

    International Nuclear Information System (INIS)

    Schneider, F.

    1981-01-01

    In the ASDEX tokamak the shots are exactly preprogrammed and most of the disturbances are reproducible. So a computer can learn from one shot how to correct the next one. With this sort of disturbance feedforward one can also introduce a 'negative delay' in the program to compensate even fast and strong disturbances withous unwanted overswing or oscillations. The feedforward in conjunction with feedback control allows production of a magnetically limited plasma from the very beginning without any wall or limiter contact. This is a reason why in ASDEX the loop voltage on breakdown can be as low as 5 V/sup 2/. The plasma column can be controlled in the vacuum vessel even after disruptions have occurred

  19. Magnetic reconnection and self-organized plasma systems

    International Nuclear Information System (INIS)

    Yamada, Masaaki; Ji, Hantao

    2000-01-01

    In this paper the recent results from the Magnetic Reconnection Experiment (MRX) at PPPL are discussed along with their relationship to observations from solar flares, the magnetosphere, and current carrying pinch discharges such as tokamaks, reversed field pinches, spheromaks and field reversed configurations. It is found that the reconnection speed decreases as the angle of merging field lines decreases, consistent with the well-established observation in the dayside magnetosphere. This observation can also provide a qualitative interpretation of a generally observed trend in pinch plasmas, namely that magnetic field diffuses (or reconnects) faster when magnetic shear is larger. A recently conceived research project, SPIRIT (Self-organized Plasma with Induction, Reconnection, and Injection Techniques), will also be discussed. (author)

  20. Plasmablasts and plasma cells: reconsidering teleost immune system organization.

    Science.gov (United States)

    Ye, Jianmin; Kaattari, Ilsa; Kaattari, Stephen

    2011-12-01

    Comparative immunologists have expended extensive efforts in the characterization of early fish B cell development; however, analysis of the post-antigen induction stages of antibody secreting cell (ASC) differentiation has been limited. In contrast, work with murine ASCs has resolved the physically and functionally distinct cells known as plasmablasts, the short-lived plasma cells and long-lived plasma cells. Teleost ASCs are now known to also possess comparable subpopulations, which can greatly differ in such basic functions as lifespan, antigen sensitivity, antibody secretion rate, differentiative potential, and distribution within the body. Understanding the mechanisms by which these subpopulations are produced and distributed is essential for both basic understanding in comparative immunology and practical vaccine engineering. Copyright © 2011 Elsevier Ltd. All rights reserved.

  1. Real time control of plasmas and ECRH systems on TCV

    International Nuclear Information System (INIS)

    Paley, J.I.; Berrino, J.; Coda, S.; Duval, B.P.; Felici, F.; Goodman, T.P.; Martin, Y.; Moret, J.M.; Piras, F.; Cruz, N.; Rodriques, A.P.; Santos, B.; Varandas, C.A.F.

    2009-01-01

    Developments in the real time control hardware on Tokamak a Configuration Variable (TCV) coupled with the flexibility of plasma shaping and electron cyclotron (EC) heating and current drive actuators are opening many opportunities to perform real time experiments and develop algorithms and methods for fusion applications. The ability to control magnetohydrodynamic instabilities is particularly important for achieving high performance fusion plasmas and EC is envisaged as a key actuator in maintaining high performance. We have successfully demonstrated control of the sawtooth instability using the EC launcher injection angle to modify the current profile around the q =1 surface. This paper presents an overview of recent real time control experiments on TCV, developments in the hardware and algorithms together with plans for the future.

  2. Manufacturing of central control system of 'JT-60' a plasma feasibility experiment device

    International Nuclear Information System (INIS)

    Kondo, Ikuo; Kimura, Toyoaki; Murai, Katsuji; Iba, Daizo; Takemaru, Koichi.

    1984-01-01

    For constructing a critical-plasma-experiment apparatus JT-60, it was necessary to develop a new control system which enables to operate safely and smoothly a large scale nuclear fusion apparatus and to carry out efficient experiment. For the purpose, the total system control facility composed of such controllers as CAMAC system, timing system and protective interlock panel with multi-computer system as the core was developed. This system generalizes, keeps watch on and controls the total facilities as the key point of the control system of JT-60, and allows flexible operation control corresponding to the diversified experimental projects. At the same time, it carries out the fast real-time control of high temperature, high density plasma. In this paper, the system constitution, function and the main contents of development of the total system control facility are reported. JT-60 is constructed to attain the critical plasma condition as the premise of nuclear fusion reactors and to scientifically verify controlled nuclear fusion. Plasma expe riment will be started in April, 1985. The real-time control of plasma for carrying out high beta operation is planned, intending to develop future economical practical reactors. (Kako, I.)

  3. Transport in zonal flows in analogous geophysical and plasma systems

    Science.gov (United States)

    del-Castillo-Negrete, Diego

    1999-11-01

    Zonal flows occur naturally in the oceans and the atmosphere of planets. Important examples include the zonal flows in Jupiter, the stratospheric polar jet in Antarctica, and oceanic jets like the Gulf Stream. These zonal flows create transport barriers that have a crucial influence on mixing and confinement (e.g. the ozone depletion in Antarctica). Zonal flows also give rise to long-lasting vortices (e.g. the Jupiter red spot) by shear instability. Because of this, the formation and stability of zonal flows and their role on transport have been problems of great interest in geophysical fluid dynamics. On the other hand, zonal flows have also been observed in fusion plasmas and their impact on the reduction of transport has been widely recognized. Based on the well-known analogy between Rossby waves in quasigeostrophic flows and drift waves in magnetically confined plasmas, I will discuss the relevance to fusion plasmas of models and experiments recently developed in geophysical fluid dynamics. Also, the potential application of plasma physics ideas to geophysical flows will be discussed. The role of shear in the suppression of transport and the effect of zonal flows on the statistics of transport will be studied using simplified models. It will be shown how zonal flows induce large particle displacements that can be characterized as Lévy flights, and that the trapping effect of vortices combined with the zonal flows gives rise to anomalous diffusion and Lévy (non-Gaussian) statistics. The models will be compared with laboratory experiments and with atmospheric and oceanographic qualitative observations.

  4. Amplification through chaotic synchronization in spatially extended beam-plasma systems

    Science.gov (United States)

    Moskalenko, Olga I.; Frolov, Nikita S.; Koronovskii, Alexey A.; Hramov, Alexander E.

    2017-12-01

    In this paper, we have studied the relationship between chaotic synchronization and microwave signal amplification in coupled beam-plasma systems. We have considered a 1D particle-in-cell numerical model of unidirectionally coupled beam-plasma oscillatory media being in the regime of electron pattern formation. We have shown the significant gain of microwave oscillation power in coupled beam-plasma media being in the different regimes of generation. The discovered effect has a close connection with the chaotic synchronization phenomenon, so we have observed that amplification appears after the onset of the complete time scale synchronization regime in the analyzed coupled spatially extended systems. We have also provided the numerical study of physical processes in the chain of beam-plasma systems leading to the chaotic synchronization and the amplification of microwave oscillations power, respectively.

  5. Human leukocyte antigen-G in the male reproductive system and in seminal plasma

    DEFF Research Database (Denmark)

    Horup Larsen, Margit; Bzorek, Michael; Pass, Malene B.

    2011-01-01

    -eclampsia. We have investigated whether HLA-G protein is present in human seminal plasma and in different tissue samples of the male reproductive system.Western blot technique and a soluble HLA-G (sHLA-G) assay were used to detect sHLA-G in human seminal plasma samples. Immunohistochemical staining...... was performed on paraffin-embedded tissue samples. We detected sHLA-G protein in seminal plasma, and HLA-G expression in normal testis and in epididymal tissue of the male reproductive system but not in the seminal vesicle. Furthermore, the results indicated a weak expression of HLA–G in hyperplastic prostatic...... tissue. In summary, several of the findings reported in this study suggest an immunoregulatory role of HLA-G in the male reproductive system and in seminal plasma....

  6. Comparison study of nitrogen and argon processing in a plasma arc centrifugal treatment system

    International Nuclear Information System (INIS)

    Shuey, M.; Tsuji, Y.

    2000-01-01

    Recent testing performed at the plasma research center of Retech Services, Inc. compared nitrogen with argon as plasma gas in the processing of simulated wastes. The testing took place in a full-scale production PACT system under a cooperative research and development study between Retech Services Inc. and Toyo Engineering Corporation. This study shows that simulated waste can be processed by both nitrogen and argon plasmas. Heat losses to the torch nozzle were significantly lower with argon and should be studied further. Both argon and nitrogen plasma were able to process feeds containing both metals and oxides. Some of the drawbacks to using argon plasma are cost, higher volume flow rates, and dual mode torch nozzle erosion. (authors)

  7. Theory of the dynamic stability of plasma systems

    International Nuclear Information System (INIS)

    Bud'ko, A.B.; Velikovich, A.L.; Kleev, A.I.; Liberman, M.A.; Felber, F.S.

    1989-01-01

    Internal instabilities of the plasma of a diffuse pinch result from the acceleration of the plasma in the course of its compression and the expansion of the current channel. The spectra of the growth rates σ m,k of the hydromagnetic instabilities responsible for the disruption of the initial cylindrical symmetry during compression are calculated. For a Z-pinch with a Gaussian density profile, the major instabilities in the course of the compression are the small-scale sausage and kink instabilities with kR >> 1 (R is a typical radius of the pinch). Superimposed on these small-scale instabilities is a filamentation instability with m >> 1, which develops more slowly. If the density instead has a power-law profile, the filamentation instabilities will develop more rapidly than the sausage and kink instabilities. Dynamic stabilization of a pinch by a longitudinal magnetic field makes it possible to maintain symmetry up to radial compressions of the plasma significantly higher than in the absence of a field

  8. Exposure assessment of prepubertal children to steroid endocrine disrupters 1. Analytical strategy for estrogens measurement in plasma at ultra-trace level

    DEFF Research Database (Denmark)

    Courant, Frédérique; Antignac, Jean-Philippe; Maume, Daniel

    2007-01-01

    Global concern has been raised in recent years over adverse effects that may result from exposure to chemicals that may interfere with the endocrine system. A specific question is related to low-dose effects and long-term exposure consequences, especially for critical populations (foetus, new born...

  9. Comparative occupational radiation exposure between fixed and mobile imaging systems.

    Science.gov (United States)

    Kendrick, Daniel E; Miller, Claire P; Moorehead, Pamela A; Kim, Ann H; Baele, Henry R; Wong, Virginia L; Jordan, David W; Kashyap, Vikram S

    2016-01-01

    Endovascular intervention exposes surgical staff to scattered radiation, which varies according to procedure and imaging equipment. The purpose of this study was to determine differences in occupational exposure between procedures performed with fixed imaging (FI) in an endovascular suite compared with conventional mobile imaging (MI) in a standard operating room. A series of 116 endovascular cases were performed over a 4-month interval in a dedicated endovascular suite with FI and conventional operating room with MI. All cases were performed at a single institution and radiation dose was recorded using real-time dosimetry badges from Unfors RaySafe (Hopkinton, Mass). A dosimeter was mounted in each room to establish a radiation baseline. Staff dose was recorded using individual badges worn on the torso lead. Total mean air kerma (Kar; mGy, patient dose) and mean case dose (mSv, scattered radiation) were compared between rooms and across all staff positions for cases of varying complexity. Statistical analyses for all continuous variables were performed using t test and analysis of variance where appropriate. A total of 43 cases with MI and 73 cases with FI were performed by four vascular surgeons. Total mean Kar, and case dose were significantly higher with FI compared with MI. (mean ± standard error of the mean, 523 ± 49 mGy vs 98 ± 19 mGy; P < .00001; 0.77 ± 0.03 mSv vs 0.16 ± 0.08 mSv, P < .00001). Exposure for the primary surgeon and assistant was significantly higher with FI compared with MI. Mean exposure for all cases using either imaging modality, was significantly higher for the primary surgeon and assistant than for support staff (ie, nurse, radiology technologist) beyond 6 feet from the X-ray source, indicated according to one-way analysis of variance (MI: P < .00001; FI: P < .00001). Support staff exposure was negligible and did not differ between FI and MI. Room dose stratified according to case complexity (Kar) showed statistically significantly

  10. Investigation of uniformity field generated from freeform lens with UV LED exposure system

    Science.gov (United States)

    Ciou, F. Y.; Chen, Y. C.; Pan, C. T.; Lin, P. H.; Lin, P. H.; Hsu, F. T.

    2015-03-01

    In the exposure process, the intensity and uniformity of light in the exposure area directly influenced the precision of products. UV-LED (Ultraviolet Light-Emitting Diode) exposure system was established to reduce the radiation leakage and increase the energy efficiency for energy saving. It is a trend that conventional mercury lamp could be replaced with UV-LED exposure system. This study was based on the law of conservation of energy and law of refraction of optical field distributing on the target plane. With these, a freeform lens with uniform light field of main exposure area could be designed. The light outside the exposure area could be concentrated into the area to improve the intensity of light. The refraction index and UV transmittance of Polydimethylsiloxane (PDMS) is 1.43 at 385 nm wavelength and 85-90%, respectively. The PDMS was used to fabricate the optics lens for UV-LEDs. The average illumination and the uniformity could be obtained by increasing the number of UV-LEDs and the spacing of different arrangement modes. After exposure process with PDMS lens, about 5% inaccuracy was obtained. Comparing to 10% inaccuracy of general exposure system, it shows that it is available to replace conventional exposure lamp with using UV-LEDs.

  11. [Advances in research on automatic exposure control of mammography system].

    Science.gov (United States)

    Wang, Guoyi; Ye, Chengfu; Wu, Haiming; Wang, Tainfu; Zhang, Hong

    2014-12-01

    Mammography imaging is one of the most demanding imaging modalities from the point of view of the bal- ance between image quality (the visibility of small size and/or low contrast structures) and dose (screening of many asymptomatic people). Therefore, since the introduction of the first dedicated mammographic units, many efforts have been directed to seek the best possible image quality while minimizing patient dose. The performance of auto- matic exposure control (AEC) is the manifestation of this demand. The theory of AEC includes exposure detection and optimization and also involves some accomplished methodology. This review presents the development and present situa- tion of spectrum optimization, detector evolution, and the way how to accomplish and evaluate AEC methods.

  12. The influence of potential exposure to radiation protection system of accelerator installation TESLA

    International Nuclear Information System (INIS)

    Orlic, M.; Cuknic, O.

    2000-01-01

    Potential exposure of individuals at big nuclear machines like Accelerator Installation Tesla (AIT) generates direct requirements to reliability of radiation protection system. Starting from technical characteristics of AlT and international recommendation concerning potential exposure and the probability of death has been calculated. The reference risk has been specified. Comparing then we calculated the probability of the failure of the protective system. The reliability of the system has to be better (author)

  13. Harmonisation of food categorisation systems for dietary exposure assessments among European children

    DEFF Research Database (Denmark)

    De Neve, Melissa; Sioen, Isabelle; Boon, Polly

    2010-01-01

    Within the European project called EXPOCHI (Individual Food Consumption Data and Exposure Assessment Studies for Children), 14 different European individual food consumption databases of children were used to conduct harmonised dietary exposure assessments for lead, chromium, selenium and food...... colours. For this, two food categorisation systems were developed to classify the food consumption data in such a way that these could be linked to occurrence data of the considered compounds. One system served for the exposure calculations of lead, chromium and selenium. The second system was developed...... for the exposure assessment of food colours. The food categories defined for the lead, chromium and selenium exposure calculations were used as a basis for the food colour categorisation, with adaptations to optimise the linkage with the food colour occurrence data. With this work, an initial impetus was given...

  14. Occupational and public field exposure from communication, navigation, and radar systems used for air traffic control.

    Science.gov (United States)

    Joseph, Wout; Goeminne, Francis; Vermeeren, Günter; Verloock, Leen; Martens, Luc

    2012-12-01

    Electromagnetic exposure (occupational and general public) to 14 types of air traffic control (ATC) systems is assessed. Measurement methods are proposed for in situ exposure assessment of these ATC systems. In total, 50 sites are investigated at 1,073 locations in the frequency range of 255 kHz to 24 GHz. For all installations, typical and maximal exposure values for workers and the general public are provided. Two of the 14 types of systems, Non-Directional Beacons (NDB) (up to 881.6 V m) and Doppler Very High Frequency (VHF) Omni-directional Range (DVOR) (up to 92.3 V m), exhibited levels requiring recommended minimum distances such that the ICNIRP reference levels are not exceeded. Cumulative exposure of all present radiofrequency (RF) sources is investigated, and it is concluded that the ATC source dominates the total exposure in its neighborhood.

  15. Pentylenetetrazol modulates redox system by inducing addicsin translocation from endoplasmic reticulum to plasma membrane in NG108-15 cells

    Directory of Open Access Journals (Sweden)

    Mitsushi J. Ikemoto

    2017-09-01

    Full Text Available Addicsin (Arl6ip5 is a multifunctional physiological and pathophysiological regulator that exerts its effects by readily forming homo- and hetero-complexes with various functional factors. In particular, addicsin acts as a negative modulator of neural glutamate transporter excitatory amino acid carrier 1 (EAAC1 and participates in the regulation of intracellular glutathione (GSH content by negatively modulating EAAC1-mediated cysteine and glutamate uptake. Addicsin is considered to play a crucial role in the onset of neurodegenerative diseases including epilepsy. However, the molecular dynamics of addicsin remains largely unknown. Here, we report the dynamics of addicsin in NG108-15 cells upon exposure to pentylenetetrazol (PTZ, a representative epileptogenic agent acting on the gamma-Aminobutyric acid A (GABAA receptor. Fluorescent immunostaining analysis demonstrated that addicsin drastically changed its localization from the endoplasmic reticulum (ER to the plasma membrane within 1 h of PTZ exposure in a dose-dependent manner. Moreover, addicsin was co-localized with the plasma membrane markers EAAC1 and Na+/K+ ATPase alpha-3 upon PTZ stimulation. This translocation was significantly inhibited by a non-competitive GABAA receptor antagonist, picrotoxin, but not by a competitive GABAA receptor antagonist, bicuculline. Furthermore, lactate dehydrogenase (LDH assay and 2,2-diphenyl-1-picrylhydrazyl (DPPH radical-scavenging assay showed that PTZ-induced addicsin translocation was accompanied by a decrease of radical-scavenging activity and an increase of cytotoxicity in a PTZ dose-dependent manner. These findings suggest that PTZ induces the translocation of addicsin from the ER to the plasma membrane and modulates the redox system by regulating EAAC1-mediated GSH synthesis, which leads to the activation of cell death signaling.

  16. Evaluation of air-liquid interface exposure systems for in vitro assessment of airborne pollutants

    Science.gov (United States)

    Exposure of cells to airborne pollutants at the air-liquid interface (ALI) is a more realistic approach than exposures of submerged cells. The published literature, however, describes irreproducible and/or unrealistic experimental conditions using ALI systems. We have compared fi...

  17. A Comparison of Exposure Control Procedures in CAT Systems Based on Different Measurement Models for Testlets

    Science.gov (United States)

    Boyd, Aimee M.; Dodd, Barbara; Fitzpatrick, Steven

    2013-01-01

    This study compared several exposure control procedures for CAT systems based on the three-parameter logistic testlet response theory model (Wang, Bradlow, & Wainer, 2002) and Masters' (1982) partial credit model when applied to a pool consisting entirely of testlets. The exposure control procedures studied were the modified within 0.10 logits…

  18. Evaluating the Gifted Students' Understanding Related to Plasma State Using Plasma Experimental System and Two-Tier Diagnostic Test

    Science.gov (United States)

    Korkmaz, Saadet Deniz; Ayas, Bahadir; Aybek, Eren Can; Pat, Suat

    2018-01-01

    The purpose of this study was to investigate the effectiveness of the experimental system design related to plasma state on the gifted students' understanding on the subject of the plasma state. To test the research hypothesis, one group pretest-posttest research model was carried out with 18 eighth-grade (4 girls and 14 boys) gifted students in…

  19. Surface modification study of zirconium on exposure to fusion grade plasma in an 11.5 kJ plasma focus device

    International Nuclear Information System (INIS)

    Srivastava, Rohit; Niranjan, Ram; Rout, R.K.; Kaushik, T.C.; Chakravarthy, Y.; Mishra, P.

    2017-01-01

    In continuation of our investigation on effect of fusion grade plasma produced in an existing MEPF-12 (11.5 kJ, 40 μF, 24 kV) plasma focus (PF) facility on different materials, likely to be used in future fusion reactors, we have reported here the study on Zirconium (Zr) metal. In the present work, the Zr sample in disc (2 mm thick, 10 mm diameter) form was exposed to twenty shots of plasma focus operated at 4 mbar deuterium gas filling pressure and 11.5 kJ bank energy. The samples were placed at a distance of 6 cm from the tip of the anode in the MEPF-12 PF device. The emissions from the device comprise of deuterium ions in wide energy range (a few keV to several hundreds of keV), high temperature plasma (in general a few keV) and neutrons of 2.45 MeV energy produced due to D(D, 3 He)n fusion reactions

  20. ADVANCED TOKAMAK OPERATION USING THE DIII-D PLASMA CONTROL SYSTEM

    International Nuclear Information System (INIS)

    HUMPHREYS, DA; FERRON, JR; GAROFALO, AM; HYATT, AW; JERNIGAN, TC; JOHNSON, RD; LAHAYE, RJ; LEUER, JA; OKABAYASHI, M; PENAFLOR, BG; SCOVILLE, JT; STRAIT, EJ; WALKER, ML; WHYTE, DG

    2002-01-01

    A271 ADVANCED TOKAMAK OPERATION USING THE DIII-D PLASMA CONTROL SYSTEM. The principal focus of experimental operations in the DIII-D tokamak is the advanced tokamak (AT) regime to achieve, which requires highly integrated and flexible plasma control. In a high performance advanced tokamak, accurate regulation of the plasma boundary, internal profiles, pumping, fueling, and heating must be well coordinated with MHD control action to stabilize such instabilities as tearing modes and resistive wall modes. Sophisticated monitors of the operational regime must provide detection of off-normal conditions and trigger appropriate safety responses with acceptable levels of reliability. Many of these capabilities are presently implemented in the DIII-D plasma control system (PCS), and are now in frequent or routine operational use. The present work describes recent development, implementation, and operational experience with AT regime control elements for equilibrium control, MHD suppression, and off-normal event detection and response

  1. Effects of brevetoxin exposure on the immune system of loggerhead sea turtles.

    Science.gov (United States)

    Walsh, Catherine J; Leggett, Stephanie R; Carter, Barbara J; Colle, Clarence

    2010-05-10

    Blooms of the toxic dinoflagellate, Karenia brevis, occur almost annually off the Florida coast. These blooms, commonly called "red tides", produce a group of neurotoxins collectively termed brevetoxins. Many species of sealife, including sea turtles, are severely impacted by brevetoxin exposure. Effects of brevetoxins on immune cells were investigated in rescued loggerhead sea turtles, Caretta caretta, as well as through in vitro experiments using peripheral blood leukocytes (PBL) collected from captive sea turtles. In rescued animals, plasma brevetoxin concentrations were measured using a competitive ELISA. Plasma lysozyme activity was measured using a turbidity assay. Lysozyme activity correlated positively with plasma brevetoxin concentrations. Differential expression of genes affected by brevetoxin exposure was determined using two separate suppression subtractive hybridization experiments. In one experiment, genes from PBL collected from sea turtles rescued from red tide toxin exposure were compared to genes from PBL collected from healthy captive loggerhead sea turtles. In the second experiment, PBL from healthy captive loggerhead sea turtles were exposed to brevetoxin (500 ng PbTx-2/ml) in vitro for 18 h and compared to unexposed PBL. Results from the subtraction hybridization experiment conducted with red tide rescued sea turtle PBL indicated that genes involved in oxidative stress or xenobiotic metabolism were up-regulated. Using quantitative real-time PCR, a greater than 2-fold increase in superoxide dismutase and thioredoxin and greater than 10-fold increase in expression of thiopurine S-methyltransferase were observed. Results from the in vitro subtraction hybridization experiment indicated that genes coding for cytochrome c oxidases were the major up-regulated genes. Using quantitative real-time PCR, a greater than 8-fold increase in expression of beta-tubulin and greater than 3-fold increase in expression of ubiquinol were observed. Brevetoxin

  2. Dispersion relation of test waves in an electron beam plasma system

    International Nuclear Information System (INIS)

    Hayashi, N.; Tanaka, M.; Shinohara, S.; Kawai, Y.

    1994-01-01

    Test waves are propagated in an electron beam plasma system and the dispersion relation is measured. At the center of the experimental region a beam mode is excited. Near the chamber wall an electron plasma wave is excited and propagates from the chamber wall to the center of the experimental region. It is also found that observed unstable waves are standing wave which is formed by superposing the beam modes propagating in the opposite directions each other. (author). 6 refs, 6 figs

  3. Convective plasma stability consistent with MHD equilibrium in magnetic confinement systems with a decreasing field

    International Nuclear Information System (INIS)

    Tsventoukh, M. M.

    2010-01-01

    A study is made of the convective (interchange, or flute) plasma stability consistent with equilibrium in magnetic confinement systems with a magnetic field decreasing outward and large curvature of magnetic field lines. Algorithms are developed which calculate convective plasma stability from the Kruskal-Oberman kinetic criterion and in which the convective stability is iteratively consistent with MHD equilibrium for a given pressure and a given type of anisotropy in actual magnetic geometry. Vacuum and equilibrium convectively stable configurations in systems with a decreasing, highly curved magnetic field are calculated. It is shown that, in convectively stable equilibrium, the possibility of achieving high plasma pressures in the central region is restricted either by the expansion of the separatrix (when there are large regions of a weak magnetic field) or by the filamentation of the gradient plasma current (when there are small regions of a weak magnetic field, in which case the pressure drops mainly near the separatrix). It is found that, from the standpoint of equilibrium and of the onset of nonpotential ballooning modes, a kinetic description of convective stability yields better plasma confinement parameters in systems with a decreasing, highly curved magnetic field than a simpler MHD model and makes it possible to substantially improve the confinement parameters for a given type of anisotropy. For the Magnetor experimental compact device, the maximum central pressure consistent with equilibrium and stability is calculated to be as high as β ∼ 30%. It is shown that, for the anisotropy of the distribution function that is typical of a background ECR plasma, the limiting pressure gradient is about two times steeper than that for an isotropic plasma. From a practical point of view, the possibility is demonstrated of achieving better confinement parameters of a hot collisionless plasma in systems with a decreasing, highly curved magnetic field than those

  4. Gonadal exposure during radiotherapy of the retriperitoneal lymphatic system

    International Nuclear Information System (INIS)

    Kimmig, B.; Kober, B.; Fehrentz, D.; Heidelberg Univ.

    1980-01-01

    The most important factors leading to exposure of the gonads during irradiation of retroperitoneal lymph nodes are discussed. For radiotherapy on paraaortal lymph nodes, data given in the relevant literature and the authors own measures seveal a gonadal dose of 1% of the focal dose for men and 4% for women. The corresponding values in mantle field irradiation (paraaortal and iliac) are, without protective measures, 10%, resp. 50-75%. Finally, the consequences of a gonadal irradiation are dealt with: carcinogenesis, genetic risk and functional disorders. (orig.) [de

  5. Current status and prospect of plasma control system for steady-state operation on QUEST

    International Nuclear Information System (INIS)

    Hasegawa, Makoto; Nakamura, Kazuo; Zushi, Hideki; Hanada, Kazuaki; Fujisawa, Akihide; Tokunaga, Kazutoshi; Idei, Hiroshi; Nagashima, Yoshihiko; Kawasaki, Shoji; Nakashima, Hisatoshi; Higashijima, Aki

    2016-01-01

    Highlights: • Overall configuration of plasma control system on QUEST are presented. • Multi core system and reflective memories are used for the real-time control. • Hall sensors are used for the identification of plasma current and its position. • Repetitive gas fueling with the feed-back control of Hα signal is implemented. - Abstract: The plasma control system (PCS) of QUEST is developed according to the progress of QUEST project. Since one of the critical goals of the project is to achieve the steady-state operation with high temperature vacuum vessel wall, the PCS is also required to have the capability to control the plasma for a long period. For the increase of the loads to processing power of the PCS, the PCS is decentralized with the use of reflective memories (RFMs). The PCS controls the plasma edge position with the real-time identification of plasma current and its position. This identification is done with not only flux loops but also hall sensors. The gas fueling method by piezo valve with monitoring the Hα signal filtered by a digital low-pass filter are proposed and suitable for the steady-state operation on QUEST. The present status and prospect of the PCS are presented with recent topics.

  6. Progress in Development of the ITER Plasma Control System Simulation Platform

    Science.gov (United States)

    Walker, Michael; Humphreys, David; Sammuli, Brian; Ambrosino, Giuseppe; de Tommasi, Gianmaria; Mattei, Massimiliano; Raupp, Gerhard; Treutterer, Wolfgang; Winter, Axel

    2017-10-01

    We report on progress made and expected uses of the Plasma Control System Simulation Platform (PCSSP), the primary test environment for development of the ITER Plasma Control System (PCS). PCSSP will be used for verification and validation of the ITER PCS Final Design for First Plasma, to be completed in 2020. We discuss the objectives of PCSSP, its overall structure, selected features, application to existing devices, and expected evolution over the lifetime of the ITER PCS. We describe an archiving solution for simulation results, methods for incorporating physics models of the plasma and physical plant (tokamak, actuator, and diagnostic systems) into PCSSP, and defining characteristics of models suitable for a plasma control development environment such as PCSSP. Applications of PCSSP simulation models including resistive plasma equilibrium evolution are demonstrated. PCSSP development supported by ITER Organization under ITER/CTS/6000000037. Resistive evolution code developed under General Atomics' Internal funding. The views and opinions expressed herein do not necessarily reflect those of the ITER Organization.

  7. Current status and prospect of plasma control system for steady-state operation on QUEST

    Energy Technology Data Exchange (ETDEWEB)

    Hasegawa, Makoto, E-mail: hasegawa@triam.kyushu-u.ac.jp; Nakamura, Kazuo; Zushi, Hideki; Hanada, Kazuaki; Fujisawa, Akihide; Tokunaga, Kazutoshi; Idei, Hiroshi; Nagashima, Yoshihiko; Kawasaki, Shoji; Nakashima, Hisatoshi; Higashijima, Aki

    2016-11-15

    Highlights: • Overall configuration of plasma control system on QUEST are presented. • Multi core system and reflective memories are used for the real-time control. • Hall sensors are used for the identification of plasma current and its position. • Repetitive gas fueling with the feed-back control of Hα signal is implemented. - Abstract: The plasma control system (PCS) of QUEST is developed according to the progress of QUEST project. Since one of the critical goals of the project is to achieve the steady-state operation with high temperature vacuum vessel wall, the PCS is also required to have the capability to control the plasma for a long period. For the increase of the loads to processing power of the PCS, the PCS is decentralized with the use of reflective memories (RFMs). The PCS controls the plasma edge position with the real-time identification of plasma current and its position. This identification is done with not only flux loops but also hall sensors. The gas fueling method by piezo valve with monitoring the Hα signal filtered by a digital low-pass filter are proposed and suitable for the steady-state operation on QUEST. The present status and prospect of the PCS are presented with recent topics.

  8. Effect of high-flux H/He plasma exposure on tungsten damage due to transient heat loads

    Czech Academy of Sciences Publication Activity Database

    De Temmerman, G.; Morgan, T.W.; van Eden, G.G.; de Kruif, T.; Wirtz, M.; Matějíček, Jiří; Chráska, Tomáš; Pitts, R.A.; Wright, G.M.

    2015-01-01

    Roč. 463, August (2015), s. 198-201 ISSN 0022-3115. [PLASMA-SURFACE INTERACTIONS 21: International Conference on Plasma-Surface Interactions in Controlled Fusion Devices. Kanazawa, 26.05.2014-30.05.2014] R&D Projects: GA ČR(CZ) GA14-12837S Institutional support: RVO:61389021 Keywords : plasma-facing components * tungsten * hydrogen * helium * ELM Subject RIV: JF - Nuclear Energetics OBOR OECD: Nuclear related engineering Impact factor: 2.199, year: 2015 http://www.sciencedirect.com/science/article/pii/S0022311514006758#

  9. Exposure and acute exposure-effects before and after modification of a contaminated humidification system in a synthetic-fibre plant

    NARCIS (Netherlands)

    Pal, TM; de Monchy, JGR; Groothoff, JW; Post, D

    Objective: Follow-up study of exposure and acute exposure-effects after modification to steam humidification of a contaminated cold water system which had caused an outbreak of humidifier fever in a synthetic-fibre plant. Methods: Before and after modification of the system aerobiological

  10. Study of the influence of air exposure on graphite implanted by low energy high density deuterium plasma

    International Nuclear Information System (INIS)

    Fernandez, V.; Bardon, J.; Palmari, J.P.; Grisolia, C.

    1990-01-01

    A study of the influence of air exposure on the content of Deuterium implanted graphite was done for different exposure durations and different gas exposures. Important reduction of the D 2 thermodesorbed is shown to result from the formation of deuterated compounds during the desorption, the total amount of deuterium desorbed remaining unchanged. Some informations on the mechanisms of the interactions can be obtained by the comparison of the different experiments

  11. Results of verifications of the control automatic exposure in equipment of RX with CR systems

    International Nuclear Information System (INIS)

    Ruiz Manzano, P.; Rivas Ballarin, M. A.; Ortega Pardina, P.; Villa Gazulla, D.; Calvo Carrillo, S.; Canellas Anoz, M.; Millan Cebrian, E.

    2013-01-01

    After the entry into force in 2012, the new Spanish Radiology quality control protocol lists and discusses the results obtained after verification of the automatic control of exposure in computed radiography systems. (Author)

  12. Internal plasma diagnostic with a multichannel magnetic probe system using automatic data acquisition

    International Nuclear Information System (INIS)

    Korten, M.; Carolan, P.G.; Sand, F.; Waelbroeck, F.

    1975-04-01

    A 20-channel magnetic probe system inserted into the plasma is used to measure spatial distributions of poloidal and toroidal magnetic fields in the pulsed toroidal high β-experiment TEE. Plasma parameters, e.g. the β-value, toroidal current density and radial pressure distribution were derived applying static equilibrium theory and can be calculated from the measurements. A data acquisition system used in conjuction with a process computer was operated to obtain the experimental data automatically and to perform the multiple computational tasks. The program system described was built to serve as a first stage of a more common software system applicable for computational data handling for different diagnostics of a plasma physics confinement experiment. (orig.) [de

  13. FAR-TECH's Nanoparticle Plasma Jet System and its Application to Disruptions, Deep Fueling, and Diagnostics

    Science.gov (United States)

    Thompson, J. R.; Bogatu, I. N.; Galkin, S. A.; Kim, J. S.

    2012-10-01

    Hyper-velocity plasma jets have potential applications in tokamaks for disruption mitigation, deep fueling and diagnostics. Pulsed power based solid-state sources and plasma accelerators offer advantages of rapid response and mass delivery at high velocities. Fast response is critical for some disruption mitigation scenario needs, while high velocity is especially important for penetration into tokamak plasma and its confining magnetic field, as in the case of deep fueling. FAR-TECH is developing the capability of producing large-mass hyper-velocity plasma jets. The prototype solid-state source has produced: 1) >8.4 mg of H2 gas only, and 2) >25 mg of H2 and >180 mg of C60 in a H2/C60 gas mixture. Using a coaxial plasma gun coupled to the source, we have successfully demonstrated the acceleration of composite H/C60 plasma jets, with momentum as high as 0.6 g.km/s, and containing an estimated C60 mass of ˜75 mg. We present the status of FAR-TECH's nanoparticle plasma jet system and discuss its application to disruptions, deep fueling, and diagnostics. A new TiH2/C60 solid-state source capable of generating significantly higher quantities of H2 and C60 in <0.5 ms will be discussed.

  14. Soft x-ray imaging system for measurement of noncircular tokamak plasmas

    International Nuclear Information System (INIS)

    Fonck, R.J.; Reusch, M.; Jaehnig, K.P.; Hulse, R.; Roney, P.

    1986-08-01

    A soft x-ray camera and image processing system has been constructed to provide measurements of the internal shape of high temperature tokamak plasmas. The camera consists of a metallic-foil-filtered pinhole aperture and a microchannel plate image intensifier/convertor which produces a visible image for detection by a CCD TV camera. A wide-angle tangential view of the toroidal plasma allows a single compact camera to view the entire plasma cross section. With Be filters 12 to 50 μm thick, the signal from the microchannel plate is produced mostly by nickel L-line emissions which orignate in the hot plasma core. The measured toroidal image is numerically inverted to produce a cross-sectional soft x-ray image of the plasma. Since the internal magnetic flux surfaces are usually isothermal and the nickel emissivity depends strongly on the local electron temperature, the x-ray emission contours reflect the shape of the magnetic surfaces in the plasma interior. Initial results from the PBX tokamak experiment show clear differences in internal plasma shapes for circular and bean-shaped discharges

  15. Modulation of the Plasma Kallikrein-Kinin System Proteins Performed by Heparan Sulfate Proteoglycans

    Directory of Open Access Journals (Sweden)

    Guacyara Motta

    2017-07-01

    Full Text Available Human plasma kallikrein-kinin system proteins are related to inflammation through bradykinin. In the proximity of its target cells, high molecular weight kininogen (H-kininogen is the substrate of plasma kallikrein, which releases bradykinin from H-kininogen. Heparan sulfate proteoglycans (HSPGs play a critical role in either recruiting kinin precursors from the plasma, or in the assembly of kallikrein-kinin system components on the cell surface. Furthermore, HSPGs mediate the endocytosis and activation of H-kininogen and plasma prekallikrein. In the presence of HSPGs (Chinese hamster ovary cell, CHO-K1, wild type cells both heparin and heparan sulfate strongly inhibit the H-kininogen interaction with the cell membrane. H-kininogen is internalized in endosomal acidic vesicles in CHO-K1 but not in CHO-745 cells (mutant cells deficient in glycosaminoglycan biosynthesis. The endocytosis process is lipid raft-mediated and is dependent on caveolae. Both types of CHO cells do not internalize bradykinin-free H-kininogen. At pH 7.35, bradykinin is released from H-kininogen on the surface of CHO-745 cells only by serine proteases; however, in CHO-K1 cells either serine or cysteine proteases are found to be involved. The CHO-K1 cell lysate contains different kininogenases. Plasma prekallikrein endocytosis in CHO-K1 cells is independent of H-kininogen, and also prekallikrein is not internalized by CHO-745 cells. Plasma prekallikrein cleavage/activation is independent of glycosaminoglycans but plasma kallikrein formation is more specific on H-kininogen assembled on the cell surface through glycosaminoglycans. In this mini-review, the importance of HSPGs in the regulation of plasma kallikrein-kinin system proteins is shown.

  16. The renewed HT-7 plasma control system based on real-time Linux cluster

    Energy Technology Data Exchange (ETDEWEB)

    Yuan, Q.P., E-mail: qpyuan@ipp.ac.cn [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei (China); Xiao, B.J.; Zhang, R.R. [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei (China); Walker, M.L.; Penaflor, B.G.; Piglowski, D.A.; Johnson, R.D. [General Atomics, DIII-D National Fusion Facility, San Diego, CA (United States)

    2012-12-15

    Highlights: Black-Right-Pointing-Pointer The hardware and software structure of the new HT-7 plasma control system (HT-7 PCS) is reported. Black-Right-Pointing-Pointer All original systems were integrated in the new HT-7 PCS. And the implementation details of the control algorithms are given in the paper. Black-Right-Pointing-Pointer Different from EAST PCS, the AC operation mode is realized in HT-7 PCS. Black-Right-Pointing-Pointer The experiment results are discussed. Good control performance has been obtained. - Abstract: In order to improve the synchronization, flexibility and expansibility of the plasma control on HT-7, a new plasma control system (HT-7 PCS) was constructed. The HT-7 PCS was based on a real-time Linux cluster with a well-defined, robust and flexible software infrastructure which was adapted from DIII-D PCS. In this paper, the hardware structure and system customization details for HT-7 PCS are reported. The plasma position and current control, plasma density control and off-normal event detection, which were realized in separated systems originally, have been integrated and implemented in such HT-7 PCS. All these control algorithms have been successfully validated in the last several HT-7 experiment campaigns. Good control performance has been achieved and the experiment results are discussed in the paper.

  17. Lowering of L10 phase transition temperature of FePt thin films by single shot H+ ion exposure using plasma focus device

    International Nuclear Information System (INIS)

    Pan, Z.Y.; Lin, J.J.; Zhang, T.; Karamat, S.; Tan, T.L.; Lee, P.; Springham, S.V.; Ramanujan, R.V.; Rawat, R.S.

    2009-01-01

    FePt thin films are exposed to pulsed energetic H + ion beam from plasma focus. In irradiated films, the phase transition from the low K u disordered face-centered-cubic structure to high K u ordered face-centered-tetragonal phase was achieved at 400 deg. C with the order parameter S ranging from 0.73 to 0.83, high coercivity of about 5356 kA/m, high negative nucleation field of about 7700 kA/m and high squareness ratio ranging from 0.73 to 0.79. The advantage of using plasma focus device is that it can lower phase transition temperature and significantly enhance the magnetic properties by a pulsed single shot exposure

  18. Occupational Exposure to Antineoplastic Drugs: Identification of Job Categories Potentially Exposed throughout the Hospital Medication System

    Directory of Open Access Journals (Sweden)

    Chun-Yip Hon

    2011-09-01

    Conclusion: We found drug contamination on select surfaces at every stage of the medication system, which indicates the existence of an exposure potential throughout the facility. Our results suggest that a broader range of workers are potentially exposed than has been previously examined. These results will allow us to develop a more inclusive exposure assessment encompassing all healthcare workers that are at risk throughout the hospital medication system.

  19. Enhanced Predictions of Time to Critical Dielectric Breakdown of Materials Under Prolonged Exposure to Space Plasma Environments

    Data.gov (United States)

    National Aeronautics and Space Administration — The leading cause of spacecraft failures and malfunctions due to interactions with the space plasma environment is electrostatic discharge (ESD). The enhanced time...

  20. Study of intelligent system for control of the tokamak-ETE plasma positioning

    International Nuclear Information System (INIS)

    Barbosa, Luis Filipe de Faria Pereira Wiltgen

    2003-01-01

    The development of an intelligent neural control system of the neural type, capable to perform real time control of the plasma displacement in the experiment tokamak spheric - ETE (spherical tokamak experiment ) is presented. The ETE machine is in operation since Nov 2000, in the LAP - Plasma Associated Laboratory of the Brazilian Institute on Spatial Research (INPE) in Sao Jose dos Campos, S P, Brazil. The experiment is dedicated to study the magnetic confinement of a fusion plasma in a configuration favorable for the construction of future reactors. Nuclear fusion constitutes a renewable energy source with low environmental impact, which uses atomic energy in pacific applications for the sustainable development of humanity. One of the important questions for the attainment of fusion relates to the stability of the plasma and control of its position during the reactor operation. Therefore, the development of systems to control the plasma in tokamaks constitutes a necessary technological advance for the feasibility of nuclear fusion. In particular, the research carried out in this thesis concerns the proposal of a system to control the vertical displacement of the plasma in the ETE tokamak, aiming to obtain steady pulses in this machine. A Magnetic Levitation system (Mag Lev) was developed as part of this work, allowing to study the nonlinear behavior of a device that, from the aspect of position control, is similar (analogous) to the plasma in the ETE tokamak, This magnetic levitation system was designed, mathematically modeled and built in order to test both classical and intelligent type controllers. The results of this comparison are very promising for the use of intelligent controllers in the ETE tokamak as well as other control applications. (author)

  1. Use of the Finnish Information System on Occupational Exposure (FINJEM) in epidemiologic, surveillance, and other applications.

    Science.gov (United States)

    Kauppinen, Timo; Uuksulainen, Sanni; Saalo, Anja; Mäkinen, Ilpo; Pukkala, Eero

    2014-04-01

    This paper reviews the use of the Finnish Information System on Occupational Exposure (Finnish job-exposure matrix, FINJEM) in different applications in Finland and other countries. We describe and discuss studies on FINJEM and studies utilizing FINJEM in regard to the validity of exposure estimates, occupational epidemiology, hazard surveillance and prevention, the assessment of health risks and the burden of disease, the assessment of exposure trends and future hazards, and the construction of job-exposure matrices (JEMs) in countries other than Finland. FINJEM can be used as an exposure assessment tool in occupational epidemiology, particularly in large register-based studies. It also provides information for hazard surveillance at the national level. It is able to identify occupations with high average exposures to chemical agents and can therefore serve the priority setting of prevention. However, it has only limited use at the workplace level due to the variability of exposure between workplaces. The national estimates of exposure and their temporal trends may contribute to the assessment of both the recent and future burden of work-related health outcomes. FINJEM has also proved to be useful in the construction of other national JEMs, for example in the Nordic Occupational Cancer study in the Nordic countries. FINJEM is a quantitative JEM, which can serve many purposes and its comprehensive documentation also makes it potentially useful in countries other than Finland.

  2. Radiofrequency plasma thrusters: modeling of ion cyclotron resonance heating and system performance

    NARCIS (Netherlands)

    Lancellotti, V.; Vecchi, G.; Maggiora, R.; Pavarin, D.; Rocca, S.; Bramanti, C.

    2007-01-01

    Recent advances in plasma-based propulsion systems have led to the development of electromagnetic (RF) generation and acceleration systems, capable of providing highly controllable and wide-ranging exhaust velocities, and potentially enabling a wide range of missions from KWs to MWs levels. In this

  3. Control of ROS and RNS productions in liquid in atmospheric pressure plasma-jet system

    Science.gov (United States)

    Uchida, Giichiro; Ito, Taiki; Takenaka, Kosuke; Ikeda, Junichiro; Setsuhara, Yuichi

    2016-09-01

    Non-thermal plasma jets are of current interest in biomedical applications such as wound disinfection and even treatment of cancer tumors. Beneficial therapeutic effects in medical applications are attributed to excited species of oxygen and nitrogen from air. However, to control the production of these species in the plasma jet is difficult because their production is strongly dependent on concentration of nitrogen and oxygen from ambient air into the plasma jet. In this study, we analyze the discharge characteristics and the ROS and RNS productions in liquid in low- and high-frequency plasma-jet systems. Our experiments demonstrated the marked effects of surrounding gas near the plasma jet on ROS and RNS productions in liquid. By controlling the surround gas, the O2 and N2 main plasma jets are selectively produced even in open air. We also show that the concentration ratio of NO2- to H2O2 in liquid is precisely tuned from 0 to 0.18 in deionized water by changing N2 gas ratio (N2 / (N2 +O2)) in the main discharge gas, where high NO2- ratio is obtained at N2 gas ratio at N2 / (N2 +O2) = 0 . 8 . The low-frequency plasma jet with controlled surrounding gas is an effective plasma source for ROS and RNS productions in liquid, and can be a useful tool for biomedical applications. This study was partly supported by a Grant-in-Aid for Scientific Research on Innovative Areas ``Plasma Medical Innovation'' (24108003) from the Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT).

  4. Contamination due to memory effects in filtered vacuum arc plasma deposition systems

    CERN Document Server

    Martins, D R; Verdonck, P; Brown, I G

    2002-01-01

    Thin film synthesis by filtered vacuum arc plasma deposition is a widely used technique with a number of important emerging technological applications. A characteristic feature of the method is that during the deposition process not only is the substrate coated by the plasma, but the plasma gun itself and the magnetic field coil and/or vacuum vessel section constituting the macroparticle filter are also coated to some extent. If then the plasma gun cathode is changed to a new element, there can be a contamination of the subsequent film deposition by sputtering from various parts of the system of the previous coating species. We have experimentally explored this effect and compared our results with theoretical estimates of sputtering from the SRIM (Stopping and Range of Ions in Matter) code. We find film contamination of order 10-4 - 10-3, and the memory of the prior history of the deposition hardware can be relatively long-lasting.

  5. Equilibrium of high beta plasma in closed magnetic line system (MBT)

    International Nuclear Information System (INIS)

    Gesso, H.; Shiina, S.; Saito, K.; Nogi, Y.; Osaniai, Y.; Yoshimura, H.; Todoroki, J.; Hamada, S.; Nihon Univ., Tokyo. Atomic Energy Research Inst.)

    1985-01-01

    The beta effects on the plasma equilibrium in Modified Bumpy Torus (MBT) sector, which is an asymmetric closed line system with l = 0 and fairly large l = +- 1 field distortions, are studied. For this purpose, the equilibrium of high beta plasma produced by theta-pinch is compared with that of betaless plasma numerically calculated from the measured magnetic field profiles in device. The equilibrium condition depends weakly on beta value, but the plasma cross-section is vertically elongated as the beta value increases. The m = 1 long wavelength MHD instability is not observed during the observation time of approx. 15 μs. These experimental results are compared with MHD theory based on the new ordering taking the finiteness of l = +- 1 field distortion (deltasub(+-1) > or approx. 1) into account, which suggests significant stabilizing effects due to self formation of magnetic well and also due to the conducting wall. (author)

  6. Toward a design for the ITER plasma shape and stability control system

    International Nuclear Information System (INIS)

    Humphreys, D.A.; Leuer, J.A.; Kellman, A.G.; Haney, S.W.; Bulmer, R.H.; Pearlstein, L.D.; Portone, A.

    1994-07-01

    A design strategy for an integrated shaping and stability control algorithm for ITER is described. This strategy exploits the natural multivariable nature of the system so that all poloidal field coils are used to simultaneously control all regulated plasma shape and position parameters. A nonrigid, flux-conserving linearized plasma response model is derived using a variational procedure analogous to the ideal MHD Extended Energy Principle. Initial results are presented for the non-rigid plasma response model approach applied to an example DIII-D equilibrium. For this example, the nonrigid model is found to yield a higher passive growth rate than a rigid current-conserving plasma response model. Multivariable robust controller design methods are discussed and shown to be appropriate for the ITER shape control problem

  7. Contamination due to memory effects in filtered vacuum arc plasma deposition systems

    International Nuclear Information System (INIS)

    Martins, D.R.; Salvadori, M.C.; Verdonck, P.; Brown, I.G.

    2002-01-01

    Thin film synthesis by filtered vacuum arc plasma deposition is a widely used technique with a number of important emerging technological applications. A characteristic feature of the method is that during the deposition process not only is the substrate coated by the plasma, but the plasma gun itself and the magnetic field coil and/or vacuum vessel section constituting the macroparticle filter are also coated to some extent. If then the plasma gun cathode is changed to a new element, there can be a contamination of the subsequent film deposition by sputtering from various parts of the system of the previous coating species. We have experimentally explored this effect and compared our results with theoretical estimates of sputtering from the stopping and range of ions in matter code. We find film contamination of the order of 10 -4 -10 -3 , and the memory of the prior history of the deposition hardware can be relatively long lasting

  8. Contamination due to memory effects in filtered vacuum arc plasma deposition systems

    Energy Technology Data Exchange (ETDEWEB)

    Martins, D.R.; Salvadori, M.C.; Verdonck, P.; Brown, I.G.

    2002-08-13

    Thin film synthesis by filtered vacuum arc plasma deposition is a widely used technique with a number of important emerging technological applications. A characteristic feature of the method is that during the deposition process not only is the substrate coated by the plasma, but the plasma gun itself and the magnetic field coil and/or vacuum vessel section constituting the macroparticle filter are also coated to some extent. If then the plasma gun cathode is changed to a new element, there can be a contamination of the subsequent film deposition by sputtering from various parts of the system of the previous coating species. We have experimentally explored this effect and compared our results with theoretical estimates of sputtering from the SRIM (Stopping and Range of Ions in Matter) code. We find film contamination of order 10-4 - 10-3, and the memory of the prior history of the deposition hardware can be relatively long-lasting.

  9. Reduction of systemic exposure and toxicity of cisplatin by encapsulation in poly-lactide-co-glycolide.

    Science.gov (United States)

    Verrijk, R; Smolders, I J; Bosnie, N; Begg, A C

    1992-12-01

    The tissue distribution and normal tissue toxicity of cisplatin (cDDP) administered as poly-lactide-co-glycolide (PLAGA) microspheres, developed for loco-regional administration of cDDP to the liver, were studied in Wag/Rij rats. Venoportal administration of this formulation resulted in a reduction in total systemic and renal toxicity, which correlated with a decrease in normal tissue exposure to cDDP while maintaining high liver platinum levels. Liver-to-kidney platinum level ratios were 28 times higher after 4 h and 19 times higher after 24 h with PLAGA-cDDP microspheres than with free cDDP. Liver-to-blood platinum ratios at these times were 38 times and 36 times higher using PLAGA-cDDP. In a CC531 colon carcinoma liver micrometastases model, cytotoxicity of microsphere-released cDDP was confirmed in vivo by equal inhibition of tumor growth by PLAGA-cDDP and free cDDP over a period of 26 days. Free cDDP, however, caused significantly more histological renal damage and total body weight loss. The results were supported by the finding of higher plasma creatinine and urea concentrations 26 days after administration of free cDDP. Kidney platinum levels were 7 times lower when PLAGA-cDDP was used. These findings indicate a sparing effect on normal tissues when cDDP is targeted to the liver by formulation in PLAGA. PLAGA-cDDP microspheres may, therefore, be a useful and effective addition to current techniques of loco-regional chemotherapy for disseminated hepatic tumors.

  10. Plasma-Assisted Life and Ecological Operating System (PALEOS)

    Data.gov (United States)

    National Aeronautics and Space Administration — Practical implementation of long-duration, human space missions will require robust, reliable, advanced life support systems. Such systems have been the subject of...

  11. Design and operation of the RFX-mod plasma shape control system

    Energy Technology Data Exchange (ETDEWEB)

    Marchiori, G., E-mail: giuseppe.marchiori@igi.cnr.it [Consorzio RFX, Corso Stati Uniti 4, 35127 Padova (Italy); Finotti, C. [Consorzio RFX, Corso Stati Uniti 4, 35127 Padova (Italy); Kudlacek, O. [Università di Padova, Padova (Italy); Villone, F. [Dipartimento di Ingegneria Elettrica e dell’Informazione (DIEI), Università di Cassino (Italy); Zanca, P. [Consorzio RFX, Corso Stati Uniti 4, 35127 Padova (Italy); Abate, D. [Dipartimento di Ingegneria Elettrica e dell’Informazione (DIEI), Università di Cassino (Italy); Cavazzana, R. [Consorzio RFX, Corso Stati Uniti 4, 35127 Padova (Italy); Jackson, G.L.; Luce, T.C. [General Atomics, San Diego, CA (United States); Marrelli, L. [Consorzio RFX, Corso Stati Uniti 4, 35127 Padova (Italy)

    2016-10-15

    Highlights: • Linearized plasma response model of RFX-mod Tokamak Double/Single Null discharges. • Model based design of a vertical stability control system. • Model based design of a plasma shape LQG control system with Kalman state estimator. • Real time plasma boundary reconstruction algorithm. • Tracking and disturbance rejection experimental tests. - Abstract: The aim of executing Single Null discharges in RFX-mod operating as a Tokamak led to the design and implementation of a plasma shape feedback control system. A fully model-based approach was followed which allowed dealing with critical issues such as the presence of a conducting shell, the strong coupling of the poloidal field coils and the voltage limits of the power supplies. A Linear Quadratic regulator and a Kalman state estimator were designed and implemented in the real time MARTe framework together with an algorithm for the real-time plasma boundary reconstruction. The problem of a number of sensors along the poloidal direction adequate only for circular discharges was also successfully tackled. The development of the system and its performances in terms of tracking and disturbance rejection capability are presented in the paper.

  12. Plasma Modes

    Science.gov (United States)

    Dubin, D. H. E.

    This chapter explores several aspects of the linear electrostatic normal modes of oscillation for a single-species non-neutral plasma in a Penning trap. Linearized fluid equations of motion are developed, assuming the plasma is cold but collisionless, which allow derivation of the cold plasma dielectric tensor and the electrostatic wave equation. Upper hybrid and magnetized plasma waves in an infinite uniform plasma are described. The effect of the plasma surface in a bounded plasma system is considered, and the properties of surface plasma waves are characterized. The normal modes of a cylindrical plasma column are discussed, and finally, modes of spheroidal plasmas, and finite temperature effects on the modes, are briefly described.

  13. Contributions regarding calculus and design of an ultrasonic system used in plasma metallization

    Science.gov (United States)

    Amza, G.

    2015-11-01

    Paper presents the calculus elements and construction for the ultrasonic system used in reconditioning process by metallization. A series of necessary elements used in ultrasonic system dimensioning are given and an ultrasonic system used in reconditioning process by plasma and grain metallization are presented. Also, a calculated ultrasonic system is modelled to work in resonance regime at the frequency f = 22Khz. Stress map inside material, internal energy variation, lost energy variation on length and volume unit are presented.

  14. ACTIVE FILTER HARDWARE DESIGN and PERFORMANCE FOR THE DIII-D PLASMA CONTROL SYSTEM

    International Nuclear Information System (INIS)

    SELLERS, D.; FERRON, J.R; WALKER, M.L; BROESCH, J.D

    2004-03-01

    OAK-B135 The digital plasma control system (PCS), currently in operation on the DIII-D tokamak, requires inputs from a large number of sensors. Due to the nature of the digitizers and the relative noisy environment from which these signals are derived, each of the 32 signals must be conditioned via an active filter. Two different types of filters, Chebyshev and Bessel with fixed frequencies: 100 Hz Bessel was used for filtering the motional Stark effect diagnostic data. 800 Hz Bessel was designed to filter plasma control data and 1200 Hz Chebyshev is used with closed loop control of choppers. The performance of the plasma control system is greatly influenced by how well the actual filter responses match the software model used in the control system algorithms. This paper addresses the various issues facing the designer in matching the electrical design with the theoretical

  15. Mini-cavity plasma core reactors for dual-mode space nuclear power/propulsion systems

    International Nuclear Information System (INIS)

    Chow, S.

    1976-01-01

    A mini-cavity plasma core reactor is investigated for potential use in a dual-mode space power and propulsion system. In the propulsive mode, hydrogen propellant is injected radially inward through the reactor solid regions and into the cavity. The propellant is heated by both solid driver fuel elements surrounding the cavity and uranium plasma before it is exhausted out the nozzle. The propellant only removes a fraction of the driver power, the remainder is transferred by a coolant fluid to a power conversion system, which incorporates a radiator for heat rejection. In the power generation mode, the plasma and propellant flows are shut off, and the driver elements supply thermal power to the power conversion system, which generates electricity for primary electric propulsion purposes

  16. 8 GHz, high power, microwave system for heating of thermonuclear plasmas

    International Nuclear Information System (INIS)

    Di Giovenale, S.; Fortunato, T.; Mirizzi, F.; Roccon, M.; Sassi, M.; Tuccillo, A.A.; Maffia, G.; Baldi, L.

    1993-01-01

    The Frascati Tokamak Upgrade (FTU) is a machine included in the European Thermonuclear Fusion Program aimed at investigating high density plasmas in the presence of powerful additional RF heating systems. The Lower Hybrid Resonant Heating (LHRH) system, based on 9 independent modules, works at 8 GHz, and will generate, at full performances, a total amount of 9 MW, in the pulsed regime (pulse length = 1 s, duty cycle = 1/600). The microwave power source is a gyrotron oscillator, developed by Thomson Tubes Electroniques (France) for this specific application, and capable of producing up to 1 MW. An overmoded, low loss, circular waveguide transmits the RF power toward the plasma; an array of 12x4 rectangular waveguides (the 'grill') launches this power into the plasma. The paper describes the LHRH system for FTU and analyses both its main performances and experimental results

  17. Evaluation of IgG4+ Plasma Cell Infiltration in Patients with Systemic Plasmacytosis and Other Plasma Cell-infiltrating Skin Diseases

    Directory of Open Access Journals (Sweden)

    Shintaro Takeoka

    2018-02-01

    Full Text Available Systemic plasmacytosis is a rare skin disorder characterized by marked infiltration of plasma cells in the dermis. IgG4-related disease is pathologically characterized by lymphoplasmacytic infiltration rich in IgG4+ plasma cells, storiform fibrosis, and obliterative phlebitis, accompanied by elevated levels of serum IgG4. Reports of cases of systemic plasmacytosis with abundant infiltration of IgG4+ plasma cells has led to discussion about the relationship between systemic plasmacytosis and IgG4-related disease. This study examined IgG4+/IgG+ plasma cell ratios in 4 patients with systemic plasmacytosis and 12 patients with other skin diseases that show marked infiltration of plasma cells. Furthermore, we examined whether these cases met one of the pathological diagnostic criteria for IgG4-related disease (i.e. IgG4+/IgG plasma cells ratio of over 40%. Only one out of 4 patients with systemic plasmacytosis met the criterion. These results suggest that systemic plasmacytosis and IgG4-related disease are distinct diseases.

  18. Korean Ministry of Environment's web-based visual consumer product exposure and risk assessment system (COPER).

    Science.gov (United States)

    Lee, Hunjoo; Lee, Kiyoung; Park, Ji Young; Min, Sung-Gi

    2017-05-01

    With support from the Korean Ministry of the Environment (ME), our interdisciplinary research staff developed the COnsumer Product Exposure and Risk assessment system (COPER). This system includes various databases and features that enable the calculation of exposure and determination of risk caused by consumer products use. COPER is divided into three tiers: the integrated database layer (IDL), the domain specific service layer (DSSL), and the exposure and risk assessment layer (ERAL). IDL is organized by the form of the raw data (mostly non-aggregated data) and includes four sub-databases: a toxicity profile, an inventory of Korean consumer products, the weight fractions of chemical substances in the consumer products determined by chemical analysis and national representative exposure factors. DSSL provides web-based information services corresponding to each database within IDL. Finally, ERAL enables risk assessors to perform various exposure and risk assessments, including exposure scenario design via either inhalation or dermal contact by using or organizing each database in an intuitive manner. This paper outlines the overall architecture of the system and highlights some of the unique features of COPER based on visual and dynamic rendering engine for exposure assessment model on web.

  19. Usability styles of the plant safety monitoring and assesment system, PLASMA

    International Nuclear Information System (INIS)

    Green, M.; Hornaes, A.; Hulsund, J.E.; Vegh, J.; Major, Cs.; Lipcsei, S.; Borbely, S.

    2001-01-01

    Development of the PLASMA (Plant Safety Monitoring and Assessment) system was started in 1998 in the framework of an international Research and Development project supported by OECD/NEA. The objective of this project was to develop an on-line information system to support VVER reactor operators during the execution of symptom-based Emergency Operating Procedures (EOPs), with the Paks NPP in Hungary as the target plant. In connection with the installation of the PLASMA system at Paks NPP it was decided to perform a usability study of the system through interviewing NPP operators after they had completed a short training course on the PLASMA system and used it during a validation and training session in the training simulator at Paks. This report describes the basic process used in preparations and execution of the usability studies, including methods for gathering information and analysis of the findings from the validation. As a general conclusion from the usability studies it can be stated that the PLASMA system received very favourable ratings from the operators. User satisfaction was generally rated highly and comments from operators were positive. This is particularly encouraging considering the relatively short introduction and experience that the operators had with the system at the time of the-evaluation. (Author)

  20. Microwave exposure as a fast and cost-effective alternative of oxygen plasma treatment of indium-tin oxide electrode for application in organic solar cells

    Science.gov (United States)

    Soultati, Anastasia; Kostis, Ioannis; Papadimitropoulos, Giorgos; Zeniou, Angelos; Gogolides, Evangelos; Alexandropoulos, Dimitris; Vainos, Nikos; Davazoglou, Dimitris; Speliotis, Thanassis; Stathopoulos, Nikolaos A.; Argitis, Panagiotis; Vasilopoulou, Maria

    2017-12-01

    Pre-treatment methods are commonly employed to clean as well as to modify electrode surfaces. Many previous reports suggest that modifying the surface properties of indium tin oxide (ITO) by oxygen plasma treatment is a crucial step for the fabrication of high performance organic solar cells. In this work, we propose a fast and cost-effective microwave exposure step for the modification of the surface properties of ITO anode electrodes used in organic solar cells. It is demonstrated that a short microwave exposure improves the hydrophilicity and reduces the roughness of the ITO surface, as revealed by contact angle and atomic force microscopy (AFM) measurements, respectively, leading to a better quality of the PEDOT:PSS film coated on top of it. Similar results were obtained with the commonly used oxygen plasma treatment of ITO suggesting that microwave exposure is an effective process for modifying the surface properties of ITO with the benefits of low-cost, easy and fast processing. In addition, the influence of the microwave exposure of ITO anode electrode on the performance of an organic solar cell based on the poly(3-hexylthiophene):[6,6]-phenyl C70 butyric acid methyl ester (P3HT:PC70BM) blend is investigated. The 71% efficiency enhancement obtained in the microwave annealed-ITO based device as compared to the device with the as-received ITO was mainly attributed to the improvement in the short circuit current (J sc) and decreased leakage current caused by the reduced series and the increased shunt resistances and also by the higher charge generation efficiency, and the reduced recombination losses.

  1. Development and Integration of a Data Acquisition System for SST-1 Phase-1 Plasma Diagnostics

    International Nuclear Information System (INIS)

    Srivastava, Amit K; Sharma, Manika; Mansuri, Imran; Sharma, Atish; Raval, Tushar; Pradhan, Subrata

    2012-01-01

    Long pulse (of the order of 1000 s or more) SST-1 tokamak experiments demand a data acquisition system that is capable of acquiring data from various diagnostics channels without losing useful data (and hence physics information) while avoiding unnecessary generation of a large volume data. SST-1 Phase-1 tokamak operation has been envisaged with data acquisition of several essential diagnostics channels. These channels demand data acquisition at a sampling rate ranging from 1 kilo samples per second (KSPS) to 1 mega samples per second (MSPS). Considering the technical characteristics and requirements of the diagnostics, a data acquisition system based on PXI and CAMAC has been developed for SST-1 plasma diagnostics. Both these data acquisition systems are scalable. Present data acquisition needs involving slow plasma diagnostics are catered by the PXI based data acquisition system. On the other hand, CAMAC data acquisition hardware meets all requirements of the SST-1 Phase-1 fast plasma diagnostics channels. A graphical user interface for both data acquisition systems (PXI and CAMAC) has been developed using LabVIEW application development software. The collected data on the local hard disk are directly streaming to the central server through a dedicated network for post-shot data analysis. This paper describes the development and integration of the data acquisition system for SST-1 Phase-1 plasma diagnostics. The integrated testing of the developed data acquisition system has been performed using SST-1 central control and diagnostics signal conditioning units. In the absence of plasma shots, the integrated testing of the data acquisition system for the initial diagnostics of SST-1 Phase-1 operation has been performed with simulated physical signals. The primary engineering objective of this integrated testing is to validate the performance of the developed data acquisition system under simulated conditions close to that of actual tokamak operation. The data

  2. Latanoprost systemic exposure in pediatric and adult patients with glaucoma

    DEFF Research Database (Denmark)

    Raber, Susan; Courtney, Rachel; Maeda-Chubachi, Tomoko

    2011-01-01

    To evaluate short-term safety and steady-state systemic pharmacokinetics (PK) of latanoprost acid in pediatric subjects with glaucoma or ocular hypertension who received the adult latanoprost dose.......To evaluate short-term safety and steady-state systemic pharmacokinetics (PK) of latanoprost acid in pediatric subjects with glaucoma or ocular hypertension who received the adult latanoprost dose....

  3. Isolation of plasma membranes from the nervous system by countercurrent distribution in aqueous polymer two-phase systems.

    Science.gov (United States)

    Schindler, Jens; Nothwang, Hans Gerd

    2009-01-01

    The plasma membrane separates the cell-interior from the cell's environment. To maintain homeostatic conditions and to enable transfer of information, the plasma membrane is equipped with a variety of different proteins such as transporters, channels, and receptors. The kind and number of plasma membrane proteins are a characteristic of each cell type. Owing to their location, plasma membrane proteins also represent a plethora of drug targets. Their importance has entailed many studies aiming at their proteomic identification and characterization. Therefore, protocols are required that enable their purification in high purity and quantity. Here, we report a protocol, based on aqueous polymer two-phase systems, which fulfils these demands. Furthermore, the protocol is time-saving and protects protein structure and function.

  4. Removal performance of toluene, p-xylene and ethylene using a plasma-pretreated biotrickling system

    Energy Technology Data Exchange (ETDEWEB)

    Kim, H.J.; Han, B.; Kim, S.J.; Kim, Y.J. [Korea Inst. of Machinery and Materials (Korea, Republic of)

    2010-07-01

    The use of biological systems for removing volatile organic compounds (VOCs) from gaseous emissions was discussed. The systems rely on microorganism activity and do not produce any secondary pollution. Recently, the integration of biofiltration and UV photooxidation has been performed to remove VOCs in air. The systems using both UV photooxidation and biofiltration removed recalcitrant and VOCs more effectively than a stand-alone process using only biofiltration, because the UV pre-treatment not only removes the gases, but also changes them to easily biodegradable and water soluble byproducts such as acids and aldehydes. The biotrickling filter in this study was exposed to toluene gas only for over one month to cultivate specific microorganisms. The non-thermal plasma was a dielectric barrier discharge (DBD) plasma. The performance for removing toluene, p-xylene, and ethylene by the biotrickling filter, the plasma reactor and the plasma-pretreated bio-trickling system was investigated at a variety of flow rates and inlet concentrations of the test gases. The experimental results showed that the removal efficiencies of the integrated system of non-thermal plasma and biotrickling filter for p-xylene and ethylene were enhanced by 28.0 and 29.7 percent respectively, and increased by only 5.3 percent for toluene, as compared to those of the stand-alone biotrickling filtration. It was concluded that the plasma-pretreated biofiltration system could enhance the performance of the biotrickling filter for removing VOC gases, particularly for reducing low biodegradable pollutants with high loading which are chemically different from the cultivated gases. 12 refs., 7 figs.

  5. Effects of ascorbic acid supplementation on male reproductive system during exposure to hypoxia

    Science.gov (United States)

    Havazhagan, G.; Riar, S. S.; Kain, A. K.; Bardhan, Jaya; Thomas, Pauline

    1989-09-01

    Two groups of male rats were exposed to simulated altitudes of 6060 m and 7576 m for 6 h/day for 7 days (intermittent exposure). In two additional groups of animals exposed to the same altitude, 100 mg of ascorbic acid (AA) was fed daily for 5 days prior to the exposure period and also during the exposure period. Rats that did not receive AA showed loss of body weight and weight of reproductive organs after exposure. Sex organs showed atrophy on histological examination and there was a deterioration in spermatozoal quality. There was an increase in alkaline and acid phosphatase, and decrease in protein, sialic acid and glyceryl phosphorylcholine content in various reproductive tissues after exposure. All the above changes in histology and biochemical composition could be partially prevented by AA supplementation. AA supplementation can therefore protect the male reproductive system from deleterious effects of hypoxia. The probable mechanism of action of AA is discussed.

  6. Proceeding of JSPS-CAS Core University Program seminar on production and control of high performance plasmas with advanced plasma heating and diagnostic systems

    International Nuclear Information System (INIS)

    Gao Xiang; Morita, Shigeru

    2011-02-01

    The JSPS-CAS Core University Program (CUP) seminar on 'Production and control of high performance plasmas with advanced plasma heating and diagnostic systems' took place in Guilin Bravo Hotel, Guilin, China, 1-4 November 2010. This seminar was organized in the framework of CUP in the field of plasma and nuclear fusion. Two special talks and 46 oral talks were presented in the seminar including 36 Chinese, 18 Japanese and 4 Korean attendees. Production and control of high performance plasmas is a crucial issue for realizing an advanced nuclear fusion reactor in addition to developments of advanced plasma heating and diagnostics. This seminar was motivated along the issues. Results in the field of fusion experiments obtained through CUP activities during recent two years were summarized. Possible direction of future collaboration and further encouragement of scientific activity of younger scientists were also discussed in this seminar with future experimental plans in both countries. (author)

  7. Proceeding of JSPS-CAS core university program seminar on production and control of high performance plasmas with advanced plasma heating and diagnostic systems

    International Nuclear Information System (INIS)

    Gao Xiang; Morita, Shigeru

    2009-01-01

    The JSPS-CAS Core University Program (CUP) seminar on 'Production and control of high performance plasmas with advanced plasma heating and diagnostic systems' took place in Shiner hotel, Lijiang, China, 4-7 November 2008. This seminar was organized in the framework of CUP in the field of plasma and nuclear fusion. One special talk and 34 oral talks were presented in the seminar including 16 Japanese attendees. Production and control of high performance plasmas is a crucial issue for realizing an advanced nuclear fusion reactor in addition to developments of advanced plasma heating and diagnostics. This seminar was motivated along the issues. Results obtained from CUP activities during recent four years were summarized. Several crucial issues to be resolved near future were also extracted in this seminar. The 31 of the papers are indexed individually. (J.P.N.)

  8. Utilizing occupational exposure data to improve system design

    International Nuclear Information System (INIS)

    Cook, A.

    1980-01-01

    Designers of nuclear fuel cycle facilities are now faced with the difficult task of complying with the ICRP recommendation that all exposures shall be kept as low as reasonably achievable, economic and social factors being taken into account. This recommendation has parallels in English factory law, in which obligations are frequently qualified by the phrase ''so far as reasonably practicable'', and there is extensive experience of determining what is reasonably practicable in particular circumstances. This experience is summarized and observations made of the application of the concept ''reasonably practicable'' as a basis for understanding how the ALARA concept might be applied. The view is expressed that, in the greater part, optimization is a matter for observation and comparison rather than for theoretical calculation. If this view is accepted, it will be necessary for health physicists to consider how their attempts to keep doses as low as reasonably achievable might be presented for use by designers of the next generation of nuclear fuel cycle facilities. Also, international agreement should be reached on a common approach to data presentation and retrieval. (author)

  9. Confinement improvement in H-mode-like plasmas in helical systems

    International Nuclear Information System (INIS)

    Itoh, K.; Sanuki, H.; Itoh, S.; Fukuyama, A.; Yagi, M.

    1993-06-01

    The reduction of the anomalous transport due to the inhomogeneous radial electric field is theoretically studied for toroidal helical plasmas. The self-sustained interchange-mode turbulence is analysed for the system with magnetic shear and magnetic hill. For the system with magnetic well like conventional stellarators, the ballooning mode turbulence is studied. Influence of the radial electric field inhomogeneity on the transport coefficients and fluctuations are quantitatively shown. Unified theory of the transport coefficients in the L-mode and H-mode-like plasmas are presented. (author)

  10. Development of plasma current waveform adjusting system ZLJ for tokamak device HL-1

    International Nuclear Information System (INIS)

    Wang Shangbing; Hu Haotian; Tang Fangqun; Zhou Yongzheng; Chu Xiuzhong; Cheng Jiashun; Gao Yunxia

    1989-12-01

    The control of some typical Tokamak discharge waveforms has been achieved by using plasma current waveform adjusting system ZLJ in the ohmic heating of HL-1. The discharge waveforms include a series of regular plasma current waveforms with various slow rising rate, such as 80 kA, 450 ms long flat-topping; 100 kA, 200 ms rising; 200 ms falt-topping and 180 kA, 400 ms slow rising etc. The design principle of the system and the initial experimental results are described

  11. Two-stream instability for a light ion beam-plasma system with external magnetic field

    International Nuclear Information System (INIS)

    Okada, T.; Tazawa, H.

    1992-12-01

    For inertial confinement fusion, a focused light ion beam (LIB) is required to propagate stably through a chamber to a target. We have pointed out that the applied external magnetic field is important for LIB propagation. To investigate the influence of the external magnetic field on the LIB propagation, we analysed the electrostatic dispersion relation of magnetized light ion beam-plasma system. The particle in-cell (PIC) simulation results are presented for a light ion beam-plasma system with external magnetic field. (author)

  12. [Designing and implementation of a web-based quality monitoring system for plasma glucose measurement in multicenter population study].

    Science.gov (United States)

    Liu, Yong; Wang, Limin; Pang, Richard; Mo, Nanxun; Hu, Yan; Deng, Qian; Hu, Zhaohui

    2015-05-01

    The aim of this paper is to describe the designing and implementation of a web-based plasma glucose measurement quality monitoring system to assess the analytical quality of plasma glucose measurements in multicenter population study and provide evidence for the future studies. In the chronic non-communicable disease and related factor surveillance in China, a web based quality monitoring system for plasma glucose measurement was established to conduct evaluation on plasma glucose monitoring quality and effectiveness in 302 surveillance centers, including quality control data entry, transmission and feedback. The majority of the surveillance centers met the quality requirements and passed the evaluation of reproducibility and precision of plasma glucose measurement, only a few centers required intensive training and re-assessment. In order to ensure the completeness and reliability of plasma glucose measurement in the surveillance centers, the establishment of web-based plasma glucose measurement quality control system can facilitate the identification of the qualified surveillance centers and evaluation of plasma glucose measurement quality in different regions. Communication and training are important in ensuring plasma glucose measurement quality. It is necessary to further improve this web-based plasma glucose measurement quality monitoring system in the future to reduce the method specific plasma glucose measurement bias.

  13. Mass and energy analysis of the ions in a plasma flood system

    International Nuclear Information System (INIS)

    Wooding, A.C.; Armour, D.G.; Berg, J.A. van den; Holmes, A.J.T.; Burgess, C.; Goldberg, R.D.

    2005-01-01

    Plasma flood systems, capable of providing a copious supply of electrons are used in ion implanters to control wafer charging and provide effective space charge neutralisation of the ion beam in the post-analysis/post-deceleration section of the beamline. Under appropriate conditions the plasma from the flood system interacts with the ion beam and this bridging leads to an enhanced beam transport efficiency in the final critical stage of the beamline. The effectiveness of this process depends on the properties of the plasma emanating from the system. In this study, a plasma analyser comprising a double hemi-spherical electrostatic energy analyser and a quadrupole mass spectrometer, was used to measure the energy distributions of all the ion species leaving a magnetically confined argon plasma, generated in the discharge chamber of a conventional flood neutraliser. The energy distributions extended to surprisingly high energies and the peak structures depended strongly on discharge voltage, discharge current and gas pressure. The nature of these dependencies was complex with both the pressure and arc current affecting the way in which the ion energy distributions depended on arc voltage. In all cases, multiply charged ions played a significant role in determining the nature of the ion energy distributions

  14. Mass and energy analysis of the ions in a plasma flood system

    Energy Technology Data Exchange (ETDEWEB)

    Wooding, A.C. [Institute of Materials Research, University of Salford, Salford M54WT (United Kingdom); Armour, D.G. [Institute of Materials Research, University of Salford, Salford M54WT (United Kingdom); Berg, J.A. van den [Institute of Materials Research, University of Salford, Salford M54WT (United Kingdom)]. E-mail: j.a.vandenberg@salford.ac.uk; Holmes, A.J.T. [Marcham Scientific, Hungerford, Berks RG17 0LH (United Kingdom); Burgess, C. [Applied Materials UK Ltd., Foundry Lane, Horsham, West Sussex RH13 5PX (United Kingdom); Goldberg, R.D. [Applied Materials UK Ltd., Foundry Lane, Horsham, West Sussex RH13 5PX (United Kingdom)

    2005-08-01

    Plasma flood systems, capable of providing a copious supply of electrons are used in ion implanters to control wafer charging and provide effective space charge neutralisation of the ion beam in the post-analysis/post-deceleration section of the beamline. Under appropriate conditions the plasma from the flood system interacts with the ion beam and this bridging leads to an enhanced beam transport efficiency in the final critical stage of the beamline. The effectiveness of this process depends on the properties of the plasma emanating from the system. In this study, a plasma analyser comprising a double hemi-spherical electrostatic energy analyser and a quadrupole mass spectrometer, was used to measure the energy distributions of all the ion species leaving a magnetically confined argon plasma, generated in the discharge chamber of a conventional flood neutraliser. The energy distributions extended to surprisingly high energies and the peak structures depended strongly on discharge voltage, discharge current and gas pressure. The nature of these dependencies was complex with both the pressure and arc current affecting the way in which the ion energy distributions depended on arc voltage. In all cases, multiply charged ions played a significant role in determining the nature of the ion energy distributions.

  15. IMMUNE SYSTEM MATURITY AND SENSITIVITY TO CHEMICAL EXPOSURE

    Science.gov (United States)

    It is well established that human diseases associated with abnormal immune function, including some common infectious diseases and asthma, are considerably more prevalent at younger ages. The immune system continues to mature after birth, and functional immaturity accounts for m...

  16. Exposure to airborne particulate matter in the subway system.

    Science.gov (United States)

    Martins, Vânia; Moreno, Teresa; Minguillón, María Cruz; Amato, Fulvio; de Miguel, Eladio; Capdevila, Marta; Querol, Xavier

    2015-04-01

    The Barcelona subway system comprises eight subway lines, at different depths, with different tunnel dimensions, station designs and train frequencies. An extensive measurement campaign was performed in this subway system in order to characterise the airborne particulate matter (PM) measuring its concentration and investigating its variability, both inside trains and on platforms, in two different seasonal periods (warmer and colder), to better understand the main factors controlling it, and therefore the way to improve air quality. The majority of PM in the underground stations is generated within the subway system, due to abrasion and wear of rail tracks, wheels and braking pads caused during the motion of the trains. Substantial variation in average PM concentrations between underground stations was observed, which might be associated to different ventilation and air conditioning systems, characteristics/design of each station and variations in the train frequency. Average PM2.5 concentrations on the platforms in the subway operating hours ranged from 20 to 51 and from 41 to 91 μg m(-3) in the warmer and colder period, respectively, mainly related to the seasonal changes in the subway ventilation systems. The new subway lines with platform screen doors showed PM2.5 concentrations lower than those in the conventional system, which is probably attributable not only to the more advanced ventilation setup, but also to the lower train frequency and the design of the stations. PM concentrations inside the trains were generally lower than those on the platforms, which is attributable to the air conditioning systems operating inside the trains, which are equipped with air filters. This study allows the analysis and quantification of the impact of different ventilation settings on air quality, which provides an improvement on the knowledge for the general understanding and good management of air quality in the subway system. Copyright © 2014 The Authors. Published by

  17. Large superconducting magnet systems for plasma and fusion applications

    International Nuclear Information System (INIS)

    Heinz, W.

    1976-05-01

    Work on superconducting magnet systems and state of the art of superconducting magnet technology are described. Conceptual design consideration and problems of large magnet systems (stability, magnetic forces, cooling modes, safety) are discussed. Recent results of experimental work at Karlsruhe are reported. An outline of American and European programs is given. (orig.) [de

  18. Human bromethalin exposures reported to a U.S. Statewide Poison Control System.

    Science.gov (United States)

    Huntington, Serena; Fenik, Yelena; Vohra, Rais; Geller, Richard J

    2016-03-01

    Bromethalin is an increasingly used alternative to long-acting anticoagulant and cholecalciferol rodenticides. There are few reports of human exposures, and no existing professional society guidelines on medical management of bromethalin ingestions. The aim of this retrospective data review is to characterize bromethalin exposures reported to the California Poison Control System (CPCS) between 1997 and 2014. This is an observational retrospective case review of our statewide poison control system's electronic medical records. Following Institutional Board Review and Research Committee approvals, poison center exposures related to bromethalin were extracted using substance code and free text search strategies. Case notes of bromethalin exposures were reviewed for demographic, clinical, laboratory, and outcome information; inclusion criteria for the study was single-substance, human exposure to bromethalin. There were 129 calls related to human bromethalin exposures (three cases met exclusion criteria). The age range of cases was 7 months-90 years old, with the majority of exposures (89 cases; 70.6%), occurring in children younger than 5 years of age (median age of 2 years). Most exposures occurred in the pediatric population as a result of exploratory oral exposure. One hundred and thirteen patients (89.7%) had no effects post exposure, while 10 patients (7.9%) had a minor outcome. Adverse effects were minor, self-limited, and mostly gastrointestinal upset. There were no moderate, major, or fatal effects in our study population. The approximate ingested dose, available in six cases, ranged from 0.067 mg/kg to 0.3 mg/kg (milligrams of bromethalin ingested per kilogram of body weight), and no dose-symptom threshold could be established from this series. Exposures were not confirmed through urine or serum laboratory testing. The prognosis for most accidental ingestions appears to be excellent. However, bromethalin exposures may result in a higher number of

  19. Understanding of radiation protection in medicine. Pt. 2. Occupational exposure and system of radiation protection

    International Nuclear Information System (INIS)

    Iida, Hiroji; Yamamoto, Tomoyuki; Shimada, Yasuhiro

    1997-01-01

    Using a questionnaire we investigated whether radiation protection is correctly understood by medical doctors (n=140) and nurses (n=496). Although medical exposure is usually understood by medical doctors and dentists, their knowledge was found to be insufficient. Sixty-eight percent of medical doctors and 50% of dentists did not know about the system of radiation protection. Dose monitoring was not correctly carried out by approximately 20% of medical staff members, and medical personnel generally complained of anxiety about occupational exposure rather than medical exposure. They did not receive sufficient education on radiation exposure and protection in school. In conclusion, the results of this questionnaire suggested that they do not have adequate knowledge about radiation exposure and protection. The lack of knowledge about protection results in anxiety about exposure. To protect oneself from occupational exposure, individual radiation doses must be monitored, and medical practice should be reconsidered based on the results of monitoring. To eliminate unnecessary medical and occupational exposure and to justify practices such as radiological examinations, radiation protection should be well understood and appropriately carried out by medical doctors and dentists. Therefore, the education of medical students on the subject of radiation protection is required as is postgraduate education for medical doctors, dentists and nurses. (author)

  20. Excitation of electrostatic ion cyclotron wave in electron beam plasma system

    International Nuclear Information System (INIS)

    Fukumura, Takashi; Takamoto, Teruo

    1984-01-01

    The electrostatic ion cyclotron waves excited in an electron beam plasma system was investigated. The excitation condition of the waves was calculated by using Harris type dispersion relation under some assumption, and its comparison with the experimental result was made. Beam plasma discharge is a kind of RF discharge, and it is caused by the waves generated by the interaction of electron beam with plasma. It was shown that electrostatic ion cyclotron waves seemed to be the most probable as excited waves. But the excitation mechanism of these waves has not been concretely investigated. In this study, the excitation condition of electrostatic ion cyclotron waves was calculated as described above. The experimental apparatus and the results of potential, electric field and ion saturation current in beam plasma, electron drift motion in azimuthal direction and the waves excited in beam plasma are reported. The frequency of oscillation observed in beam plasma corresponds to the harmonics or subharmonics of ion cyclotron frequency. The calculation of Harris type dispersion relation, the numerical calculation and the comparison of the experimental result with the calculated result are described. (Kako, I.)