WorldWideScience

Sample records for plasma redshift predicts

  1. Plasma Redshift Cosmology

    Science.gov (United States)

    Brynjolfsson, Ari

    2011-04-01

    The newly discovered plasma redshift cross section explains a long range of phenomena; including the cosmological redshift, and the intrinsic redshift of Sun, stars, galaxies and quasars. It explains the beautiful black body spectrum of the CMB, and it predicts correctly: a) the observed XRB, b) the magnitude redshift relation for supernovae, and c) the surface- brightness-redshift relation for galaxies. There is no need for Big Bang, Inflation, Dark Energy, Dark Matter, Accelerated Expansion, and Black Holes. The universe is quasi-static and can renew itself forever (for details, see: http://www.plasmaredshift.org). There is no cosmic time dilation. In intergalactic space, the average electron temperature is T = 2.7 million K, and the average electron density is N = 0.0002 per cubic cm. Plasma redshift is derived theoretically from conventional axioms of physics by using more accurate methods than those conventionally used. The main difference is: 1) the proper inclusion of the dielectric constant, 2) more exact calculations of imaginary part of the dielectric constant, and as required 3) a quantum mechanical treatment of the interactions.

  2. Novel Methods for Predicting Photometric Redshifts

    Data.gov (United States)

    National Aeronautics and Space Administration — We calculate photometric redshifts from the Sloan Digital Sky Survey Main Galaxy Sample, The Galaxy Evolution Explorer All Sky Survey, and The Two Micron All Sky...

  3. Comparison of Plasma-Redshift Cosmology and Big-Bang Cosmology

    Science.gov (United States)

    Brynjolfsson, Ari

    2009-05-01

    Plasma redshift is derived theoretically from conventional axioms of physics by using more accurate methods than those conventionally used. The main difference is the proper inclusion of the dielectric constant. The force acting on the electron is proportional to E=D/ɛ and not D as is conventionally surmised. This correction is not important in ordinary laboratory plasmas; but in the hot sparse plasmas of the intergalactic space, it explains the gradual energy loss (the cosmological redshift) of photons. This energy loss of photons is transferred to the plasma and makes it very hot. The plasma redshift explains long range of phenomena, including the intrinsic redshift of Sun, stars, galaxies and quasars, and the cosmological redshift. It explains also the beautiful black body spectrum of the CMB, and it predicts the observed XRB, and much more. There is no need for Big Bang, Inflation, Dark Energy, Dark Matter, Black Holes and much more. The universe is quasi-static and can renew itself forever. There is no cosmic time dilation. In intergalactic space the average temperature is 2.7.10^6 K, and the average electron density (Ne)avg= 2 .10-4 cm-3.

  4. Redshift

    CERN Document Server

    Clark, Stuart

    1997-01-01

    The light emitted by celestial objects can have its wavelength "stretched" in different ways before it is observed by astronomers. These stretching phenomena are collectively called "redshift". They influence virtually all aspects of astronomy and even underpin the "Big Bang" theory of the creation of the universe. This book details the types of redshift and explains their myriad of uses. It begins by introducing the nature of light and the problems involved in measuring its properties. After explaining the redshift phenomena and their uses, the book touches on the age and size of the universe; two subjects embroiled in controversy because of our current interpretation of the redshift. Less conventional theories are then expressed. As a by-product of the explanation of redshift, the book offers the reader a basic understanding of Einstein's theory of relativity. Mathematical treatments of the concepts introduced in the text are boxed off and should not detract from the book's readibility, but allow it to be u...

  5. Predicting the High Redshift Galaxy Population for JWST

    Science.gov (United States)

    Flynn, Zoey; Benson, Andrew

    2017-01-01

    The James Webb Space Telescope will be launched in Oct 2018 with the goal of observing galaxies in the redshift range of z = 10 - 15. As redshift increases, the age of the Universe decreases, allowing us to study objects formed only a few hundred million years after the Big Bang. This will provide a valuable opportunity to test and improve current galaxy formation theory by comparing predictions for mass, luminosity, and number density to the observed data. We have made testable predictions with the semi-analytical galaxy formation model Galacticus. The code uses Markov Chain Monte Carlo methods to determine viable sets of model parameters that match current astronomical data. The resulting constrained model was then set to match the specifications of the JWST Ultra Deep Field Imaging Survey. Predictions utilizing up to 100 viable parameter sets were calculated, allowing us to assess the uncertainty in current theoretical expectations. We predict that the planned UDF will be able to observe a significant number of objects past redshift z > 9 but nothing at redshift z > 11. In order to detect these faint objects at redshifts z = 11-15 we need to increase exposure time by at least a factor of 1.66.

  6. Frontier Fields: High-Redshift Predictions and Early Results

    CERN Document Server

    Coe, Dan; Zitrin, Adi

    2014-01-01

    The Frontier Fields program is obtaining deep Hubble and Spitzer Space Telescope images of new "blank" fields and nearby fields gravitationally lensed by massive galaxy clusters. The Hubble images of the lensed fields are revealing nJy sources (AB mag > 31), the faintest galaxies yet observed. In this paper, we present high-redshift (z > 6) number count predictions for the full program and candidates in three of the first Hubble Frontier Fields images. The full program will transform our understanding of galaxy evolution in the first 600 million years (z > 9). Where previous programs yielded perhaps a dozen z > 9 candidates, the Frontier Fields may yield ~70 (~6 per field). We base this estimate on an extrapolation of luminosity functions observed between 4 9. This might suggest a deficit of faint z > 9 galaxies as also reported in the Ultra Deep Field (even while excesses of brighter z > 9 galaxies were reported in shallower fields). At these redshifts, cosmic variance (field-to-field variation) is expected...

  7. Can Self-Organizing Maps accurately predict photometric redshifts?

    CERN Document Server

    Way, M J

    2012-01-01

    We present an unsupervised machine learning approach that can be employed for estimating photometric redshifts. The proposed method is based on a vector quantization approach called Self--Organizing Mapping (SOM). A variety of photometrically derived input values were utilized from the Sloan Digital Sky Survey's Main Galaxy Sample, Luminous Red Galaxy, and Quasar samples along with the PHAT0 data set from the PHoto-z Accuracy Testing project. Regression results obtained with this new approach were evaluated in terms of root mean square error (RMSE) to estimate the accuracy of the photometric redshift estimates. The results demonstrate competitive RMSE and outlier percentages when compared with several other popular approaches such as Artificial Neural Networks and Gaussian Process Regression. SOM RMSE--results (using $\\Delta$z=z$_{phot}$--z$_{spec}$) for the Main Galaxy Sample are 0.023, for the Luminous Red Galaxy sample 0.027, Quasars are 0.418, and PHAT0 synthetic data are 0.022. The results demonstrate th...

  8. Predicting the Redshift 2 H-Alpha Luminosity Function Using [OIII] Emission Line Galaxies

    Science.gov (United States)

    Mehta, Vihang; Scarlata, Claudia; Colbert, James W.; Dai, Y. S.; Dressler, Alan; Henry, Alaina; Malkan, Matt; Rafelski, Marc; Siana, Brian; Teplitz, Harry I.; Bagley, Micaela; Beck, Melanie; Ross, Nathaniel R.; Rutkowski, Michael; Wang, Yun

    2015-01-01

    Upcoming space-based surveys such as Euclid and WFIRST-AFTA plan to measure Baryonic Acoustic Oscillations (BAOs) in order to study dark energy. These surveys will use IR slitless grism spectroscopy to measure redshifts of a large number of galaxies over a significant redshift range. In this paper, we use the WFC3 Infrared Spectroscopic Parallel Survey (WISP) to estimate the expected number of H-alpha emitters observable by these future surveys. WISP is an ongoing Hubble Space Telescope slitless spectroscopic survey, covering the 0.8 - 1.65 micrometers wavelength range and allowing the detection of H-alpha emitters up to z approximately equal to 1.5 and [OIII] emitters to z approximately equal to 2.3. We derive the H-alpha-[OIII] bivariate line luminosity function for WISP galaxies at z approximately equal to 1 using a maximum likelihood estimator that properly accounts for uncertainties in line luminosity measurement, and demonstrate how it can be used to derive the H-alpha luminosity function from exclusively fitting [OIII] data. Using the z approximately equal to 2 [OIII] line luminosity function, and assuming that the relation between H-alpha and [OIII] luminosity does not change significantly over the redshift range, we predict the H-alpha number counts at z approximately equal to 2 - the upper end of the redshift range of interest for the future surveys. For the redshift range 0.7 less than z less than 2, we expect approximately 3000 galaxies per sq deg for a flux limit of 3 x 10(exp -16) ergs per sec per sq cm (the proposed depth of Euclid galaxy redshift survey) and approximately 20,000 galaxies per sq deg for a flux limit of approximately 10(exp -16) ergs per sec per sq cm (the baseline depth of WFIRST galaxy redshift survey).

  9. TPZ : Photometric redshift PDFs and ancillary information by using prediction trees and random forests

    CERN Document Server

    Kind, M Carrasco

    2013-01-01

    With the growth of large photometric surveys, accurately estimating photometric redshifts, preferably as a probability density function (PDF), and fully understanding the implicit systematic uncertainties in this process has become increasingly important. In this paper, we present a new, publicly available, parallel, machine learning algorithm that generates photometric redshift PDFs by using prediction trees and random forest techniques, which we have named TPZ. This new algorithm incorporates measurement errors into the calculation while also dealing efficiently with missing values in the data. In addition, our implementation of this algorithm provides supplementary information regarding the data being analyzed, including unbiased estimates of the accuracy of the technique without resorting to a validation data set, identification of poor photometric redshift areas within the parameter space occupied by the spectroscopic training data, a quantification of the relative importance of the variables used to con...

  10. A SIMPLE TECHNIQUE FOR PREDICTING HIGH-REDSHIFT GALAXY EVOLUTION

    Energy Technology Data Exchange (ETDEWEB)

    Behroozi, Peter S. [Space Telescope Science Institute, Baltimore, MD 21218 (United States); Silk, Joseph [Institut d' Astrophysique, UMR 7095 CNRS, Université Pierre et Marie Curie, 98bis Boulevard Arago, F-75014 Paris (France)

    2015-01-20

    We show that the ratio of galaxies' specific star formation rates (SSFRs) to their host halos' specific mass accretion rates (SMARs) strongly constrains how the galaxies' stellar masses, SSFRs, and host halo masses evolve over cosmic time. This evolutionary constraint provides a simple way to probe z > 8 galaxy populations without direct observations. Tests of the method with galaxy properties at z = 4 successfully reproduce the known evolution of the stellar mass-halo mass (SMHM) relation, galaxy SSFRs, and the cosmic star formation rate (CSFR) for 5 < z < 8. We then predict the continued evolution of these properties for 8 < z < 15. In contrast to the nonevolution in the SMHM relation at z < 4, the median galaxy mass at fixed halo mass increases strongly at z > 4. We show that this result is closely linked to the flattening in galaxy SSFRs at z > 2 compared to halo SMARs; we expect that average galaxy SSFRs at fixed stellar mass will continue their mild evolution to z ∼ 15. The expected CSFR shows no breaks or features at z > 8.5; this constrains both reionization and the possibility of a steep falloff in the CSFR at z = 9-10. Finally, we make predictions for stellar mass and luminosity functions for the James Webb Space Telescope, which should be able to observe one galaxy with M {sub *} ≳ 10{sup 8} M {sub ☉} per 10{sup 3} Mpc{sup 3} at z = 9.6 and one such galaxy per 10{sup 4} Mpc{sup 3} at z = 15.

  11. Gravitational redshift of galaxies in clusters as predicted by general relativity.

    Science.gov (United States)

    Wojtak, Radosław; Hansen, Steen H; Hjorth, Jens

    2011-09-28

    The theoretical framework of cosmology is mainly defined by gravity, of which general relativity is the current model. Recent tests of general relativity within the Lambda Cold Dark Matter (ΛCDM) model have found a concordance between predictions and the observations of the growth rate and clustering of the cosmic web. General relativity has not hitherto been tested on cosmological scales independently of the assumptions of the ΛCDM model. Here we report an observation of the gravitational redshift of light coming from galaxies in clusters at the 99 per cent confidence level, based on archival data. Our measurement agrees with the predictions of general relativity and its modification created to explain cosmic acceleration without the need for dark energy (the f(R) theory), but is inconsistent with alternative models designed to avoid the presence of dark matter. © 2011 Macmillan Publishers Limited. All rights reserved

  12. Confronting predictions of the galaxy stellar mass function with observations at high-redshift

    CERN Document Server

    Wilkins, Stephen M; Croft, Rupert; Khandai, Nishikanta; Feng, Yu; Bunker, Andrew; Coulton, William

    2013-01-01

    We investigate the evolution of the galaxy stellar mass function at high-redshift ($z\\ge 5$) using a pair of large cosmological hydrodynamical simulations: {\\em MassiveBlack} and {\\em MassiveBlack-II}. By combining these simulations we can study the properties of galaxies with stellar masses greater than $10^{8}\\,{\\rm M_{\\odot}}\\,h^{-1}$ and (co-moving) number densities of $\\log_{10}(\\phi\\, [{\\rm Mpc^{-3}\\,dex^{-1}}\\,h^{3}])>-8$. Observational determinations of the galaxy stellar mass function at very-high redshift typically assume a relation between the observed UV luminosity and stellar mass-to-light ratio which is applied to high-redshift samples in order to estimate stellar masses. This relation can also be measured from the simulations. We do this, finding two significant differences with the usual observational assumption: it evolves strongly with redshift and has a different shape. Using this relation to make a consistent comparison between galaxy stellar mass functions we find that at $z=6$ and above ...

  13. Theoretical predictions for the effect of nebular emission on the broad band photometry of high-redshift galaxies

    CERN Document Server

    Wilkins, Stephen M; Caruana, Joseph; Croft, Rupert; Di Matteo, Tiziana; Khandai, Nishikanta; Feng, Yu; Bunker, Andrew; Elbert, Holly

    2013-01-01

    By combining optical and near-IR observations from the Hubble Space Telescope with NIR photometry from the Spitzer Space Telescope it is possible to measure the rest-frame UV-optical colours of galaxies at z=4-8. The UV-optical spectral energy distribution of star formation dominated galaxies is the result of several different factors. These include the joint distribution of stellar masses, ages, and metallicities, and the subsequent reprocessing by dust and gas in the ISM. Using a large cosmological hydrodynamical simulation we investigate the predicted spectral energy distributions of galaxies at high-redshift with a particular emphasis on assessing the potential contribution of nebular emission. We find that the average pure stellar UV-optical colour correlates with both luminosity and redshift such that galaxies at lower-redshift and higher-luminosity are typically redder. Assuming the escape fraction of ionising photons is close to zero, the effect of nebular emission is to redden the UV-optical 1500-V_w...

  14. Predicting the redshift 2 Halpha luminosity function using [OIII] emission line galaxies

    CERN Document Server

    Mehta, Vihang; Colbert, James W; Dai, Sophia; Dressler, Alan; Henry, Alaina; Malkan, Matt; Rafelski, Marc; Siana, Brian; Teplitz, Harry; Bagley, Micaela; Beck, Melanie; Ross, Nathaniel R; Rutkowski, Michael; Wang, Yun

    2015-01-01

    Upcoming space-based surveys such as Euclid and WFIRST-AFTA plan to measure Baryonic Acoustic Oscillations (BAOs) in order to study dark energy. These surveys will use IR slitless grism spectroscopy to measure redshifts of a large number of galaxies over a significant redshift range. In this paper, we use the WFC3 Infrared Spectroscopic Parallel Survey (WISP) to estimate the expected number of Halpha (Ha) emitters observable by these future surveys. WISP is an ongoing HST slitless spectroscopic survey, covering the 0.8-1.65micron wavelength range and allowing the detection of Ha emitters up to z~1.5 and [OIII] emitters to z~2.3. We derive the Ha-[OIII] bivariate line luminosity function for WISP galaxies at z~1 using a maximum likelihood estimator that properly accounts for uncertainties in line luminosity measurement, and demonstrate how it can be used to derive the Ha luminosity function from exclusively fitting [OIII] data. Using the z~2 [OIII] line luminosity function, and assuming that the relation betwe...

  15. New Approaches To Photometric Redshift Prediction Via Gaussian Process Regression In The Sloan Digital Sky Survey

    CERN Document Server

    Way, M J; Gazis, P R; Srivastava, A N

    2009-01-01

    Expanding upon the work of Way & Srivastava 2006 we demonstrate how the use of training sets of comparable size continue to make Gaussian Process Regression a competitive and in many ways a superior approach to that of Neural Networks and other least-squares fitting methods. This is possible via new matrix inversion techniques developed for Gaussian Processes that do not require that the kernel matrix be sparse. This development, combined with a neural-network kernel function appears to give superior results for this problem. We demonstrate that there appears to be a minimum number of training set galaxies needed to obtain the optimal fit when using our Gaussian Process Regression rank-reduction methods. We also find that morphological information included with many photometric surveys appears, for the most part, to make the photometric redshift evaluation slightly worse rather than better. This would indicate that morphological information simply adds noise from the Gaussian Process point of view. In add...

  16. ACTIVE GALACTIC NUCLEI AS MAIN CONTRIBUTORS TO THE ULTRAVIOLET IONIZING EMISSIVITY AT HIGH REDSHIFTS: PREDICTIONS FROM A {Lambda}-CDM MODEL WITH LINKED AGN/GALAXY EVOLUTION

    Energy Technology Data Exchange (ETDEWEB)

    Giallongo, E.; Menci, N.; Fiore, F.; Castellano, M.; Fontana, A.; Grazian, A.; Pentericci, L. [INAF-Osservatorio Astronomico di Roma, via di Frascati 33, I-00040 Monteporzio (Italy)

    2012-08-20

    We have evaluated the contribution of the active galactic nuclei (AGN) population to the ionization history of the universe based on a semi-analytic model of galaxy formation and evolution in the cold dark matter cosmological scenario. The model connects the growth of black holes and of the ensuing AGN activity to galaxy interactions. In the model we have included a self-consistent physical description of the escape of ionizing UV photons; this is based on the blast-wave model for the AGN feedback we developed in a previous paper to explain the distribution of hydrogen column densities in AGNs of various redshifts and luminosities, due to absorption by the host galaxy gas. The model predicts UV luminosity functions for AGNs that are in good agreement with those derived from the observations especially at low and intermediate redshifts (z {approx} 3). At higher redshifts (z > 5), the model tends to overestimate the data at faint luminosities. Critical biases in both the data and in the model are discussed to explain such apparent discrepancies. The predicted hydrogen photoionization rate as a function of redshift is found to be consistent with that derived from the observations. All of the above suggests that we should reconsider the role of the AGNs as the main driver of the ionization history of the universe.

  17. The systematics of strong lens modeling quantified: the effects of constraint selection and redshift information on magnification, mass, and multiple image predictability

    CERN Document Server

    Johnson, Traci L

    2016-01-01

    Until now, systematic errors in strong gravitational lens modeling have been acknowledged but never been fully quantified. Here, we launch an investigation into the systematics induced by constraint selection. We model the simulated cluster Ares 362 times using random selections of image systems with and without spectroscopic redshifts and quantify the systematics using several diagnostics: image predictability, accuracy of model-predicted redshifts, enclosed mass, and magnification. We find that for models with $>15$ image systems, the image plane rms does not decrease significantly when more systems are added; however the rms values quoted in the literature may be misleading as to the ability of a model to predict new multiple images. The mass is well constrained near the Einstein radius in all cases, and systematic error drops to $10$ image systems. Magnification errors are smallest along the straight portions of the critical curve, and the value of the magnification is systematically lower near curved por...

  18. On the gravitational redshift

    CERN Document Server

    Wilhelm, Klaus

    2013-01-01

    The study of the gravitational redshift -- a relative wavelength increase of $\\approx 2 \\times 10^{-6}$ was predicted for solar radiation by Einstein in 1908 -- is still an important subject in modern physics. In a dispute whether or not atom interferometry experiments can be employed for gravitational redshift measurements, two research teams have recently disagreed on the physical cause of the shift. Regardless of any discussion on the interferometer aspect -- we find that both groups of authors miss the important point that the ratio of gravitational to the electrostatic forces is generally very small. For instance, the gravitational force acting on an electron in a hydrogen atom situated in the Sun's photosphere to the electrostatic force between the proton and the electron is approximately $3 \\times 10^{-21}$. A comparison of this ratio with the predicted and observed solar redshift indicates a discrepancy of many orders of magnitude. Here we show, with Einstein's early assumption of the frequency of spe...

  19. Anxiety, cortisol, and attachment predict plasma oxytocin

    NARCIS (Netherlands)

    Tops, Mattie; Van Peer, Jacobien M.; Korf, Jakob; Wijers, Albertus A.; Tucker, Don M.

    2007-01-01

    Oxytocin and attachment seem to interact in suppressing subjective anxiety and physiological stress responses. In this study we investigated the relationships between individual differences in trait attachment scores, state and trait anxiety, plasma cortisol, and plasma oxytocin levels in healthy pr

  20. Astrometric Redshifts for Quasars

    CERN Document Server

    Kaczmarczik, Michael C; Mehta, Sajjan S; Schlegel, David J

    2009-01-01

    The wavelength dependence of atmospheric refraction causes differential chromatic refraction (DCR), whereby objects imaged at different optical/UV wavelengths are observed at slightly different positions in the plane of the detector. Strong spectral features induce changes in the effective wavelengths of broad-band filters that are capable of producing significant positional offsets with respect to standard DCR corrections. We examine such offsets for broad-emission-line (type 1) quasars from the Sloan Digital Sky Survey (SDSS) spanning 0predicted by convolving a composite quasar spectrum with the SDSS bandpasses as a function of redshift and airmass. This astrometric information can be used to break degeneracies in photometric redshifts of quasars (or other emission-line sources) and, for extreme cases, may be suitable for determining "astrometric redshifts". On the SDSS's southern equatorial stripe, where it is pos...

  1. AGNs as main contributors to the UV ionizing emissivity at high redshifts: predictions from a Lambda-CDM model with linked AGN/galaxy evolution

    CERN Document Server

    Giallongo, E; Fiore, F; Castellano, M; Fontana, A; Grazian, A; Pentericci, L

    2012-01-01

    We have evaluated the contribution of the AGN population to the ionization history of the Universe based on a semi-analytic model of galaxy formation and evolution in the CDM cosmological scenario. The model connects the growth of black holes and of the ensuing AGN activity to galaxy interactions. In the model we have included a self consistent physical description of the escape of ionizing UV photons; this is based on the blast-wave model for the AGN feedback we developed in a previous paper to explain the distribution of hydrogen column densities in AGNs of various redshifts and luminosities, due to absorption by the host galaxy gas. The model predicts UV luminosity functions for AGNs which are in good agreement with those derived from the observations especially at low and intermediate redshifts (z=3). At higher redshifts (z>5) the model tends to overestimate the data at faint luminosities. Critical biases both in the data and in the model are discussed to explain such apparent discrepancies. The predicted...

  2. Prediction of the plasma distribution using an artificial neural network

    Institute of Scientific and Technical Information of China (English)

    Li Wei; Chen JunFang; Wang Teng

    2009-01-01

    In this work, an artificial neural network (ANN) model is established using a back-propagation training algorithm in order to predict the plasma spatial distribution in an electron cyclotron resonance (ECR) - plasma-enhanced chemical vapor deposition (PECVD) plasma system. In our model, there are three layers: the input layer, the hidden layer and the output layer. The input layer is composed of five neurons: the radial position, the axial position, the gas pressure,the microwave power and the magnet coil current. The output layer is our target output neuron: the plasma density.The accuracy of our prediction is tested with the experimental data obtained by a Langmuir probe, and ANN results show a good agreement with the experimental data. It is concluded that ANN is a useful tool in dealing with some nonlinear problems of the plasma spatial distribution.

  3. A Model for Intrinsic Redshifts of Quasars

    CERN Document Server

    Hansen, Peter M

    2015-01-01

    The large observed redshift of quasars has suggested large cosmological distances and a corresponding enormous energy output to explain the brightness or luminosity as seen at earth. Alternative or complementary sources of redshift have not been identified by the astronomical community. This study examines one possible source of additional redshift: an intrinsic component based on the plasma characteristics of high temperature and high electron density which are believed to be present.

  4. The 82-plex plasma protein signature that predicts increasing inflammation

    DEFF Research Database (Denmark)

    Tepel, Martin; Beck, Hans C; Tan, Qihua;

    2015-01-01

    transplant recipients and quantified 359 plasma proteins simultaneously using nano-Liquid-Chromatography-Tandem Mass-Spectrometry in individual samples and plasma C-reactive protein on the index day and the next day. Next-day C-reactive protein increased in 59 patients whereas it decreased in 32 patients......The objective of the study was to define the specific plasma protein signature that predicts the increase of the inflammation marker C-reactive protein from index day to next-day using proteome analysis and novel bioinformatics tools. We performed a prospective study of 91 incident kidney....... The prediction model selected and validated 82 plasma proteins which determined increased next-day C-reactive protein (area under receiver-operator-characteristics curve, 0.772; 95% confidence interval, 0.669 to 0.876; P protein signature (P 

  5. The redshift distribution of the TOUGH survey

    DEFF Research Database (Denmark)

    Jakobsson, P.; Hjorth, J.; Malesani, D.

    2013-01-01

    to a maximum of 14% (5%) for z > 6 (z > 7). The mean redshift of the host sample is assessed to be. Using this more complete sample, we confirm previous findings that the GRB rate at high redshift () appears to be in excess of predictions based on assumptions that it should follow conventional determinations......, making the survey the most comprehensive in terms of redshift completeness of any sample to the full Swift depth, available to date. We present the cumulative redshift distribution and derive a conservative, yet small, associated uncertainty. We constrain the fraction of Swift GRBs at high redshift...

  6. Prediction of plasma simulation data with the Gaussian process method

    Energy Technology Data Exchange (ETDEWEB)

    Preuss, R.; Toussaint, U. von, E-mail: udo.v.toussaint@ipp.mpg.de [Max-Planck-Institute for Plasma Physics, EURATOM Association, 85748 Garching (Germany)

    2014-12-05

    The simulation of plasma-wall interactions of fusion plasmas is extremely costly in computer power and time - the running time for a single parameter setting is easily in the order of weeks or months. We propose to exploit the already gathered results in order to predict the outcome for parametric studies within the high dimensional parameter space. For this we utilize Gaussian processes within the Bayesian framework and perform validation with one and two dimensional test cases from which we learn how to assess the outcome. Finally, the newly implemented method is applied to simulated data from the scrape-off layer of a fusion plasma. Uncertainties of the predictions are provided which point the way to parameter settings of further (expensive) simulations.

  7. The redshift-distance relation.

    Science.gov (United States)

    Segal, I E

    1993-06-01

    Key predictions of the Hubble law are inconsistent with direct observations on equitable complete samples of extragalactic sources in the optical, infrared, and x-ray wave bands-e.g., the predicted dispersion in apparent magnitude is persistently greatly in excess of its observed value, precluding an explanation via hypothetical perturbations or irregularities. In contrast, the predictions of the Lundmark (homogeneous quadratic) law are consistent with the observations. The Lundmark law moreover predicts the deviations between Hubble law predictions and observation with statistical consistency, while the Hubble law provides no explanation for the close fit of the Lundmark law. The flux-redshift law F [symbol, see text] (1 + z)/z appears consistent with observations on equitable complete samples in the entire observed redshift range, when due account is taken of flux limits by an optimal statistical method. Under the theoretical assumption that space is a fixed sphere, as in the Einstein universe, this law implies the redshift-distance relation z = tan2(r/2R), where R is the radius of the spherical space. This relation coincides with the prediction of chronometric cosmology, which estimates R as 160 +/- 40 Mpc (1 parsec = 3.09 x 10(16) m) from the proper motion to redshift relation of superluminal sources. Tangential aspects, including statistical methodology, fundamental physical theory, bright cluster galaxy samples, and proposed luminosity evolution, are briefly considered.

  8. Plasma neurofilament light chain predicts progression in progressive supranuclear palsy.

    Science.gov (United States)

    Rojas, Julio C; Karydas, Anna; Bang, Jee; Tsai, Richard M; Blennow, Kaj; Liman, Victor; Kramer, Joel H; Rosen, Howard; Miller, Bruce L; Zetterberg, Henrik; Boxer, Adam L

    2016-03-01

    Blood-based biomarkers for neurodegenerative conditions could improve diagnosis and treatment development. Neurofilament light chain (NfL), a marker of axonal injury, is elevated in cerebrospinal fluid (CSF) of patients with progressive supranuclear palsy (PSP). The goal of this study was to determine the diagnostic and prognostic value of plasma NfL in patients with PSP. Plasma NfL was measured with ultrasensitive digital immunoassay-based technology at baseline and 1-year follow-up in a pilot cohort of 15 PSP patients and 12 healthy controls, and a validation cohort of 147 PSP patients. Mixed linear models tested the ability of plasma NfL to predict neurological, cognitive and functional decline, and brain atrophy. Baseline mean plasma NfL levels were elevated in PSP patients (31 ± 4 pg/mL, vs. control, 17.5 ± 1 pg/mL, P NfL levels had more severe neurological (PSPRS, -36.9% vs. -28.9%, P = 0.04), functional (SEADL, -38.2% vs. -20%, P = 0.03), and neuropsychological (RBANS, -23.9% vs. -12.3%, P = 001) deterioration over 1 year. Higher baseline NfL predicted greater whole-brain and superior cerebellar peduncle volume loss. Plasma and CSF NfL were significantly correlated (r = 0.74, P = 0.002). Plasma NfL is elevated in PSP and could be of value as a biomarker both to assist clinical diagnosis and to monitor pharmacodynamic effects on the neurodegenerative process in clinical trials.

  9. Predicting Plasma Glucose From Interstitial Glucose Observations Using Bayesian Methods

    DEFF Research Database (Denmark)

    Hansen, Alexander Hildenbrand; Duun-Henriksen, Anne Katrine; Juhl, Rune

    2014-01-01

    One way of constructing a control algorithm for an artificial pancreas is to identify a model capable of predicting plasma glucose (PG) from interstitial glucose (IG) observations. Stochastic differential equations (SDEs) make it possible to account both for the unknown influence of the continuous...... glucose monitor (CGM) and for unknown physiological influences. Combined with prior knowledge about the measurement devices, this approach can be used to obtain a robust predictive model. A stochastic-differential-equation-based gray box (SDE-GB) model is formulated on the basis of an identifiable...

  10. Cosmological Constraints with Clustering-Based Redshifts

    CERN Document Server

    Kovetz, Ely D; Rahman, Mubdi

    2016-01-01

    We demonstrate that observations lacking reliable redshift information, such as photometric and radio continuum surveys, can produce robust measurements of cosmological parameters when empowered by clustering-based redshift estimation. This method infers the redshift distribution based on the spatial clustering of sources, using cross-correlation with a reference dataset with known redshifts. Applying this method to the existing SDSS photometric galaxies, and projecting to future radio continuum surveys, we show that sources can be efficiently divided into several redshift bins, increasing their ability to constrain cosmological parameters. We forecast constraints on the dark-energy equation-of-state and on local non-gaussianity parameters. We explore several pertinent issues, including the tradeoff between including more sources versus minimizing the overlap between bins, the shot-noise limitations on binning, and the predicted performance of the method at high redshifts. Remarkably, we find that, once this ...

  11. QSAR Models for the Prediction of Plasma Protein Binding

    Directory of Open Access Journals (Sweden)

    Zeshan Amin

    2013-02-01

    Full Text Available Introduction: The prediction of plasma protein binding (ppb is of paramount importance in the pharmacokinetics characterization of drugs, as it causes significant changes in volume of distribution, clearance and drug half life. This study utilized Quantitative Structure – Activity Relationships (QSAR for the prediction of plasma protein binding. Methods: Protein binding values for 794 compounds were collated from literature. The data was partitioned into a training set of 662 compounds and an external validation set of 132 compounds. Physicochemical and molecular descriptors were calculated for each compound using ACD labs/logD, MOE (Chemical Computing Group and Symyx QSAR software packages. Several data mining tools were employed for the construction of models. These included stepwise regression analysis, Classification and Regression Trees (CART, Boosted trees and Random Forest. Results: Several predictive models were identified; however, one model in particular produced significantly superior prediction accuracy for the external validation set as measured using mean absolute error and correlation coefficient. The selected model was a boosted regression tree model which had the mean absolute error for training set of 13.25 and for validation set of 14.96. Conclusion: Plasma protein binding can be modeled using simple regression trees or multiple linear regressions with reasonable model accuracies. These interpretable models were able to identify the governing molecular factors for a high ppb that included hydrophobicity, van der Waals surface area parameters, and aromaticity. On the other hand, the more complicated ensemble method of boosted regression trees produced the most accurate ppb estimations for the external validation set.

  12. Neoclassical Predictions of ``Electron Root'' Plasmas at HSX

    Science.gov (United States)

    Lore, Jeremy; Anderson, David; Briesemeister, Alexis; Talmadge, Joseph; Zhai, Kan; Guttenfelder, Walter; Spong, Don

    2008-11-01

    Recent neoclassical transport calculations at HSX for discharges with very peaked electron temperature profiles (Te(0)>2.5keV) show predictions of large (>400V/cm) radial electric fields in the plasma core. The existence of this ``electron root'' is due to the ion poloidal resonance with Te>>Ti, and it is predicted to have an effect on both neoclassical and anomalous transport. Calculations were made using the DKES code [1], which uses a non-momentum conserving collision operator. Initial results will be shown from the PENTA code [2] based on a moments method which recovers the effects of momentum conservation by including effects of the parallel flows. Results of plasma density and ECRH power scans will be presented as investigations into the experimental existence of the `electron root' and possible internal transport barrier formation. [1] W.I. van Rij and S.P. Hirshman, Phys. Fluids B 1, 563 (1989) [2] D.A. Spong, Phys. Plasmas 12, 056114 (2005) This work is supported by DOE Grant DE-FG02-93ER54222.

  13. Plasma long-chain free fatty acids predict mammalian longevity.

    Science.gov (United States)

    Jové, Mariona; Naudí, Alba; Aledo, Juan Carlos; Cabré, Rosanna; Ayala, Victoria; Portero-Otin, Manuel; Barja, Gustavo; Pamplona, Reinald

    2013-11-28

    Membrane lipid composition is an important correlate of the rate of aging of animals and, therefore, the determination of their longevity. In the present work, the use of high-throughput technologies allowed us to determine the plasma lipidomic profile of 11 mammalian species ranging in maximum longevity from 3.5 to 120 years. The non-targeted approach revealed a specie-specific lipidomic profile that accurately predicts the animal longevity. The regression analysis between lipid species and longevity demonstrated that the longer the longevity of a species, the lower is its plasma long-chain free fatty acid (LC-FFA) concentrations, peroxidizability index, and lipid peroxidation-derived products content. The inverse association between longevity and LC-FFA persisted after correction for body mass and phylogenetic interdependence. These results indicate that the lipidomic signature is an optimized feature associated with animal longevity, emerging LC-FFA as a potential biomarker of longevity.

  14. Effective dose delivery in atmospheric pressure plasma jets for plasma medicine: a model predictive control approach

    Science.gov (United States)

    Gidon, Dogan; Graves, David B.; Mesbah, Ali

    2017-08-01

    Atmospheric pressure plasma jets (APPJs) have been identified as a promising tool for plasma medicine. This paper aims to demonstrate the importance of using model-based feedback control strategies for safe, reproducible, and therapeutically effective application of APPJs for dose delivery to a target substrate. Key challenges in model-based control of APPJs arise from: (i) the multivariable, nonlinear nature of system dynamics, (ii) the need for constraining the system operation within an operating region that ensures safe plasma treatment, and (iii) the cumulative, nondecreasing nature of dose metrics. To systematically address these challenges, we propose a model predictive control (MPC) strategy for real-time feedback control of a radio-frequency APPJ in argon. To this end, a lumped-parameter, physics-based model is developed for describing the jet dynamics. Cumulative dose metrics are defined for quantifying the thermal and nonthermal energy effects of the plasma on substrate. The closed-loop performance of the MPC strategy is compared to that of a basic proportional-integral control system. Simulation results indicate that the MPC stategy provides a versatile framework for dose delivery in the presence of disturbances, while the safety and practical constraints of the APPJ operation can be systematically handled. Model-based feedback control strategies can lead to unprecedented opportunities for effective dose delivery in plasma medicine.

  15. Plasma disruption prediction using machine learning methods: DIII-D

    Science.gov (United States)

    Lupin-Jimenez, L.; Kolemen, E.; Eldon, D.; Eidietis, N.

    2016-10-01

    Plasma disruption prediction is becoming more important with the development of larger tokamaks, due to the larger amount of thermal and magnetic energy that can be stored. By accurately predicting an impending disruption, the disruption's impact can be mitigated or, better, prevented. Recent approaches to disruption prediction have been through implementation of machine learning methods, which characterize raw and processed diagnostic data to develop accurate prediction models. Using disruption trials from the DIII-D database, the effectiveness of different machine learning methods are characterized. Developed real time disruption prediction approaches are focused on tearing and locking modes. Machine learning methods used include random forests, multilayer perceptrons, and traditional regression analysis. The algorithms are trained with data within short time frames, and whether or not a disruption occurs within the time window after the end of the frame. Initial results from the machine learning algorithms will be presented. Work supported by US DOE under the Science Undergraduate Laboratory Internship (SULI) program, DE-FC02-04ER54698, and DE-AC02-09CH11466.

  16. Redshift drift in a pressure gradient cosmology

    CERN Document Server

    Balcerzak, Adam

    2012-01-01

    We derive the redshift drift formula for the inhomogeneous pressure spherically symmetric Stephani universes which are complementary to inhomogeneous density Lema\\^itre-Tolman-Bondi (LTB) models. We show that there is a clear difference between the redshift drift predictions for these two models. The Stephani models have positive drift values at small redshift and behave qualitatively as the $\\Lambda$CDM models while the drift for LTB models is always negative. This prediction can be tested in future space experiments such as E-ELT, TMT, GMT or CODEX.

  17. A physiologically based in silico kinetic model predicting plasma cholesterol concentrations in humans

    NARCIS (Netherlands)

    Pas, van de N.C.A.; Woutersen, R.A.; Ommen, van B.; Rietjens, I.M.C.M.; Graaf, de A.A.

    2012-01-01

    Increased plasma cholesterol concentration is associated with increased risk of cardiovascular disease. This study describes the development, validation, and analysis of a physiologically based kinetic (PBK) model for the prediction of plasma cholesterol concentrations in humans. This model was dire

  18. A physiologically based in silico kinetic model predicting plasma cholesterol concentrations in humans

    NARCIS (Netherlands)

    Pas, N.C.A. van de; Woutersen, R.A.; Ommen, B. van; Rietjens, I.M.C.M.; Graaf, A.A. de

    2012-01-01

    Increased plasma cholesterol concentration is associated with increased risk of cardiovascular disease. This study describes the development, validation, and analysis of a physiologically based kinetic (PBK) model for the prediction of plasma cholesterol concentrations in humans. This model was

  19. A distinct metabolic signature predicts development of fasting plasma glucose.

    Science.gov (United States)

    Hische, Manuela; Larhlimi, Abdelhalim; Schwarz, Franziska; Fischer-Rosinský, Antje; Bobbert, Thomas; Assmann, Anke; Catchpole, Gareth S; Pfeiffer, Andreas Fh; Willmitzer, Lothar; Selbig, Joachim; Spranger, Joachim

    2012-02-02

    High blood glucose and diabetes are amongst the conditions causing the greatest losses in years of healthy life worldwide. Therefore, numerous studies aim to identify reliable risk markers for development of impaired glucose metabolism and type 2 diabetes. However, the molecular basis of impaired glucose metabolism is so far insufficiently understood. The development of so called 'omics' approaches in the recent years promises to identify molecular markers and to further understand the molecular basis of impaired glucose metabolism and type 2 diabetes. Although univariate statistical approaches are often applied, we demonstrate here that the application of multivariate statistical approaches is highly recommended to fully capture the complexity of data gained using high-throughput methods. We took blood plasma samples from 172 subjects who participated in the prospective Metabolic Syndrome Berlin Potsdam follow-up study (MESY-BEPO Follow-up). We analysed these samples using Gas Chromatography coupled with Mass Spectrometry (GC-MS), and measured 286 metabolites. Furthermore, fasting glucose levels were measured using standard methods at baseline, and after an average of six years. We did correlation analysis and built linear regression models as well as Random Forest regression models to identify metabolites that predict the development of fasting glucose in our cohort. We found a metabolic pattern consisting of nine metabolites that predicted fasting glucose development with an accuracy of 0.47 in tenfold cross-validation using Random Forest regression. We also showed that adding established risk markers did not improve the model accuracy. However, external validation is eventually desirable. Although not all metabolites belonging to the final pattern are identified yet, the pattern directs attention to amino acid metabolism, energy metabolism and redox homeostasis. We demonstrate that metabolites identified using a high-throughput method (GC-MS) perform well in

  20. Computational lipidology: predicting lipoprotein density profiles in human blood plasma.

    Directory of Open Access Journals (Sweden)

    Katrin Hübner

    2008-05-01

    Full Text Available Monitoring cholesterol levels is strongly recommended to identify patients at risk for myocardial infarction. However, clinical markers beyond "bad" and "good" cholesterol are needed to precisely predict individual lipid disorders. Our work contributes to this aim by bringing together experiment and theory. We developed a novel computer-based model of the human plasma lipoprotein metabolism in order to simulate the blood lipid levels in high resolution. Instead of focusing on a few conventionally used predefined lipoprotein density classes (LDL, HDL, we consider the entire protein and lipid composition spectrum of individual lipoprotein complexes. Subsequently, their distribution over density (which equals the lipoprotein profile is calculated. As our main results, we (i successfully reproduced clinically measured lipoprotein profiles of healthy subjects; (ii assigned lipoproteins to narrow density classes, named high-resolution density sub-fractions (hrDS, revealing heterogeneous lipoprotein distributions within the major lipoprotein classes; and (iii present model-based predictions of changes in the lipoprotein distribution elicited by disorders in underlying molecular processes. In its present state, the model offers a platform for many future applications aimed at understanding the reasons for inter-individual variability, identifying new sub-fractions of potential clinical relevance and a patient-oriented diagnosis of the potential molecular causes for individual dyslipidemia.

  1. Uncertain Photometric Redshifts

    CERN Document Server

    Polsterer, Kai Lars; Gieseke, Fabian

    2016-01-01

    Photometric redshifts play an important role as a measure of distance for various cosmological topics. Spectroscopic redshifts are only available for a very limited number of objects but can be used for creating statistical models. A broad variety of photometric catalogues provide uncertain low resolution spectral information for galaxies and quasars that can be used to infer a redshift. Many different techniques have been developed to produce those redshift estimates with increasing precision. Instead of providing a point estimate only, astronomers start to generate probabilistic density functions (PDFs) which should provide a characterisation of the uncertainties of the estimation. In this work we present two simple approaches on how to generate those PDFs. We use the example of generating the photometric redshift PDFs of quasars from SDSS(DR7) to validate our approaches and to compare them with point estimates. We do not aim for presenting a new best performing method, but we choose an intuitive approach t...

  2. Time-dependent Integrated Predictive Modeling of ITER Plasmas

    Institute of Scientific and Technical Information of China (English)

    R.V. Budny

    2007-01-01

    @@ Introduction Modeling burning plasmas is important for speeding progress toward practical Tokamak energy production. Examples of issues that can be elucidated by modelinginclude requirements for heating, fueling, torque, and current drive systems, design of diagnostics, and estimates of the plasma performance (e.g., fusion power production) in various plasma scenarios. The modeling should be time-dependent to demonstrate that burning plasmas can be created, maintained (controlled), and terminated successfully. The modeling also should be integrated to treat self-consistently the nonlinearities and strong coupling between the plasma, heating, current drive, confinement, and control systems.

  3. Simple predictive electron transport models applied to sawtoothing plasmas

    Science.gov (United States)

    Kim, D.; Merle, A.; Sauter, O.; Goodman, T. P.

    2016-05-01

    In this work, we introduce two simple transport models to evaluate the time evolution of electron temperature and density profiles during sawtooth cycles (i.e. over a sawtooth period time-scale). Since the aim of these simulations is to estimate reliable profiles within a short calculation time, two simplified ad-hoc models have been developed. The goal for these models is to rely on a few easy-to-check free parameters, such as the confinement time scaling factor and the profiles’ averaged scale-lengths. Due to the simplicity and short calculation time of the models, it is expected that these models can also be applied to real-time transport simulations. We show that it works well for Ohmic and EC heated L- and H-mode plasmas. The differences between these models are discussed and we show that their predictive capabilities are similar. Thus only one model is used to reproduce with simulations the results of sawtooth control experiments on the TCV tokamak. For the sawtooth pacing, the calculated time delays between the EC power off and sawtooth crash time agree well with the experimental results. The map of possible locking range is also well reproduced by the simulation.

  4. Journeying the Redshift Desert

    CERN Document Server

    Renzini, Alvio

    2009-01-01

    The cosmic star formation rate, AGN activity, galaxy growth, mass assembly and morphological differentiation all culminate at redshift $\\sim 2$. Yet, the redshift interval $1.4\\lsim z\\lsim 3$ is harder to explore than the closer and the more distant Universe. In spite of so much action taking place in this spacetime portion of the Universe, it has been dubbed the ``Redshift Desert'', as if very little was happening within its boundaries. The difficulties encountered in properly mapping the galaxy populations inhabiting the Desert are illustrated in this paper, along with some possible remedy.

  5. Gravitational redshifts from large-scale structure

    CERN Document Server

    Croft, Rupert A C

    2013-01-01

    The recent measurement of the gravitational redshifts of galaxies in galaxy clusters by Wojtak et al. has opened a new observational window on dark matter and modified gravity. By stacking clusters this determination effectively used the line of sight distortion of the cross-correlation function of massive galaxies and lower mass galaxies to estimate the gravitational redshift profile of clusters out to 4 Mpc/h. Here we use a halo model of clustering to predict the distortion due to gravitational redshifts of the cross-correlation function on scales from 1 - 100 Mpc/h. We compare our predictions to simulations and use the simulations to make mock catalogues relevant to current and future galaxy redshift surveys. Without formulating an optimal estimator, we find that the full BOSS survey should be able to detect gravitational redshifts from large-scale structure at the ~4 sigma level. Upcoming redshift surveys will greatly increase the number of galaxies useable in such studies and the BigBOSS and Euclid exper...

  6. A New Redshift Interpretation

    CERN Document Server

    Gentry, R V

    1997-01-01

    A nonhomogeneous universe with vacuum energy, but without spacetime expansion, is utilized together with gravitational and Doppler redshifts as the basis for proposing a new interpretation of the Hubble relation and the 2.7K Cosmic Blackbody Radiation.

  7. MARZ: Redshifting Program

    Science.gov (United States)

    Hinton, Samuel

    2016-05-01

    MARZ analyzes objects and produces high quality spectroscopic redshift measurements. Spectra not matched correctly by the automatic algorithm can be redshifted manually by cycling automatic results, manual template comparison, or marking spectral features. The software has an intuitive interface and powerful automatic matching capabilities on spectra, and can be run interactively or from the command line, and runs as a Web application. MARZ can be run on a local server; it is also available for use on a public server.

  8. Spherical Redshift Distortions

    OpenAIRE

    1995-01-01

    Peculiar velocities induce apparent line of sight displacements of galaxies in redshift space, distorting the pattern of clustering in the radial versus transverse directions. On large scales, the amplitude of the distortion yields a measure of the dimensionless linear growth rate $\\beta \\approx \\Omega^{0.6}/b$, where $\\Omega$ is the cosmological density and $b$ the linear bias factor. To make the maximum statistical use of the data in a wide angle redshift survey, and for the greatest accura...

  9. Predicting high harmonic ion cyclotron heating efficiency in Tokamak plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Green, David L [ORNL; Jaeger, E. F. [XCEL; Berry, Lee A [ORNL; Chen, Guangye [ORNL; Ryan, Philip Michael [ORNL; Canik, John [ORNL

    2011-01-01

    Observations of improved radio frequency (RF) heating efficiency in high-confinement (H-) mode plasmas on the National Spherical Tokamak Experiment (NSTX) are investigated by whole-device linear simulation. We present the first full-wave simulation to couple kinetic physics of the well confined core plasma to the poorly confined scrape-off plasma. The new simulation is used to scan the launched fast-wave spectrum and examine the steady-state electric wave field structure for experimental scenarios corresponding to both reduced, and improved RF heating efficiency. We find that launching toroidal wave-numbers that required for fast-wave propagation excites large amplitude (kVm 1 ) coaxial standing modes in the wave electric field between the confined plasma density pedestal and conducting vessel wall. Qualitative comparison with measurements of the stored plasma energy suggest these modes are a probable cause of degraded heating efficiency. Also, the H-mode density pedestal and fast-wave cutoff within the confined plasma allow for the excitation of whispering gallery type eigenmodes localised to the plasma edge.

  10. QSARs for Plasma Protein Binding: Source Data and Predictions

    Data.gov (United States)

    U.S. Environmental Protection Agency — The dataset has all of the information used to create and evaluate 3 independent QSAR models for the fraction of a chemical unbound by plasma protein (Fub) for...

  11. BLAST: the Redshift Survey

    CERN Document Server

    Eales, Stephen; Devlin, Mark J; Dye, Simon; Halpern, Mark; Hughes, David H; Marsden, Gaelen; Mauskopf, Philip; Moncelsi, Lorenzo; Netterfield, Calvin B; Pascale, Enzo; Patanchon, Guillaume; Raymond, Gwenifer; Rex, Marie; Scott, Douglas; Semisch, Christopher; Siana, Brian; Truch, Matthew D P; Viero, Marco P

    2009-01-01

    The Balloon-borne Large Aperture Submillimeter Telescope (BLAST) has recently surveyed ~=8.7 deg^2 centered on GOODS-South at 250, 350 and 500 microns. In Dye et al. (2009) we presented the catalogue of sources detected at $\\rm 5\\sigma$ in at least one band in this field and the probable counterparts to these sources in other wavebands. In this paper, we present the results of a redshift survey in which we succeeded in measuring redshifts for 83 of these counterparts. We have used the spectroscopic redshifts to carry out a test of the ability of photometric redshift methods to estimate the redshifts of dusty galaxies. We have also investigated the cases where there are two possible counterparts to the BLAST source, finding that in at least half of these there is evidence that the two galaxies are physically associated, either because they are interacting or because they are in the same large-scale structure. Finally, we have made the first direct measurements of the luminosity function in the three BLAST band...

  12. Fast redshift clustering with the Baire (ultra) metric

    CERN Document Server

    Murtagh, Fionn

    2011-01-01

    The Baire metric induces an ultrametric on a dataset and is of linear computational complexity, contrasted with the standard quadratic time agglomerative hierarchical clustering algorithm. We apply the Baire distance to spectrometric and photometric redshifts from the Sloan Digital Sky Survey using, in this work, about half a million astronomical objects. We want to know how well the (more cos\\ tly to determine) spectrometric redshifts can predict the (more easily obtained) photometric redshifts, i.e. we seek to regress the spectrometric on the photometric redshifts, and we develop a clusterwise nearest neighbor regression procedure for this.

  13. Low plasma adiponectin concentrations do not predict weight gain in humans

    DEFF Research Database (Denmark)

    Vozarova, Barbora; Stefan, Norbert; Lindsay, Robert S;

    2002-01-01

    Low concentrations of plasma adiponectin, the most abundant adipose-specific protein, are observed in obese individuals and predict the development of type 2 diabetes. Administration of adiponectin to rodents prevented diet-induced weight gain, suggesting a potential etiologic role...... of hypoadiponectinemia in the development of obesity. Our aim was to prospectively examine whether low plasma adiponectin concentrations predict future weight gain in Pima Indians, explaining the predictive effect of adiponectin on the development of type 2 diabetes. We measured plasma adiponectin concentrations in 219...... an etiologic role in development of obesity in Pima Indians. Therefore, the predictive effect of low plasma adiponectin concentrations on the development of type 2 diabetes seems to be mediated by factors other than increased adiposity....

  14. The high redshift galaxy population in hierarchical galaxy formation models

    CERN Document Server

    Kitzbichler, M G; Kitzbichler, Manfred G.; White, Simon D. M.

    2006-01-01

    We compare observations of the high redshift galaxy population to the predictions of the galaxy formation model of Croton et al. (2006). This model, implemented on the Millennium Simulation of the concordance LCDM cosmogony, introduces "radio mode" feedback from the central galaxies of groups and clusters in order to obtain quantitative agreement with the luminosity, colour, morphology and clustering properties of the low redshift galaxy population. Here we compare the predictions of this same model to the observed counts and redshift distributions of faint galaxies, as well as to their inferred luminosity and mass functions out to redshift 5. With the exception of the mass functions, all these properties are sensitive to modelling of dust obscuration. A simple but plausible treatment gives moderately good agreement with most of the data, although the predicted abundance of relatively massive (~M*) galaxies appears systematically high at high redshift, suggesting that such galaxies assemble earlier in this mo...

  15. Cholecystokinin in plasma predicts cardiovascular mortality in elderly females

    DEFF Research Database (Denmark)

    Gøtze, Jens P.; Rehfeld, Jens F; Alehagen, Urban

    2016-01-01

    observed a marked difference between the genders, where CCK concentrations in the 4th quartile were associated with a higher 5-year cardiovascular mortality in female patients (HR 8.99, 95% C.I.: 3.49-102.82, p=0.0007) compared to men (1.47, 95% C.I.: 0.7-3.3, p=0.35). In contrast, no significant...... information was obtained from 4th quartile gastrin concentrations on 5-year cardiovascular mortality risk. CONCLUSIONS: CCK in plasma is an independent marker of cardiovascular mortality in elderly female patients. The study thus introduces measurement of plasma CCK in gender-specific cardiovascular risk......BACKGROUND: Cholecystokinin (CCK) and gastrin are related gastrointestinal hormones with documented cardiovascular effects of exogenous administration. It is unknown whether measurement of endogenous CCK or gastrin in plasma contains information regarding cardiovascular mortality. METHODS...

  16. Comparisons of Predicted Plasma Performance in ITER H-mode Plasmas with Various Mixes of External He

    Energy Technology Data Exchange (ETDEWEB)

    R.V. Budny

    2009-03-20

    Performance in H-mode DT plasmas in ITER with various choices of heating systems are predicted and compared. Combinations of external heating by Negative Ion Neutral Beam Injection (NNBI), Ion Cyclotron Range of Frequencies (ICRF), and Electron Cyclotron Heating (ECH) are assumed. Scans with a range of physics assumptions about boundary temperatures in the edge pedestal, alpha ash transport, and toroidal momentum transport are used to indicate effects of uncertainties. Time-dependent integrated modeling with the PTRANSP code is used to predict profiles of heating, beam torque, and plasma profiles. The GLF23 model is used to predict temperature profiles. Either GLF23 or the assumption of a constant ratio for χø/χi is used to predict toroidal rotation profiles driven by the beam torques. Large differences for the core temperatures are predicted with different mixes of the external heating during the density and current ramp-up phase, but the profiles are similar during the flattop phase. With χø/χi = 0.5, the predicted toroidal rotation is relatively slow and the flow shear implied by the pressure, toroidal rotation, and neoclassical poloidal rotation are not sufficient to cause significant changes in the energy transport or steady state temperature profiles. The GLF23-predicted toroidal rotation is faster by a factor of six, and significant flow shear effects are predicted.

  17. Changing universe model of redshift

    CERN Document Server

    Hodge, J C

    2004-01-01

    The changing universe model (CUM) describes galaxy parameter relationships (SESAPS '03, session EB 2). The CUM must be successfully applied to cosmological scale observations to be considered a cosmological model. A major component of current cosmological models is the Hubble constant $H_\\mathrm{o}$. An equation is derived using the CUM model relating redshift $z$ and the distance $D$ to galaxies and is applied to a sample of 32 spiral galaxies with $D$ calculated using Cepheid variable stars. The equation predicts a galaxy may have $z<0$ in special circumstances. Three elliptical galaxies with peculiar characteristics are discovered to be CUM Sinks. The Sinks give a physical explanation of the ``Virgocentric infall'' and ``Great Attractor'' observations without a large, unobserved mass. At low cosmological distances, the equation reduces to $z \\approx \\exp(KD) -1 \\approx KD$, where $K$ is a constant, positive value. The equation predicts $z$ from galaxies over 23 Gpc distant approaches a constant value on...

  18. The Redshift Evolution of LCDM Halo Parameters

    CERN Document Server

    Muñoz-Cuartas, J C; Gottlöber, Stefan; Dutton, Aaron

    2011-01-01

    We study the mass and redshift dependence of the concentration parameter in Nbody simulations spanning masses from $10^{10} \\hMsun$ to $10^{15} \\hMsun$ and redshifts from 0 to 2. We present a series of fitting formulas that accurately describe the time evolution of the concentration-mass relation since z=2. Using arguments based on the spherical collapse model we study the behaviour of the scale length of the density profile during the assembly history of haloes, obtaining physical insights on the origin of the observed time evolution of the concentration mass relation. We present preliminary results of the implementation of this model in the prediction of the values of the concentration parameter for different masses and redshifts.

  19. The redshift distribution of the TOUGH survey

    DEFF Research Database (Denmark)

    Jakobsson, P.; Hjorth, J.; Malesani, D.;

    2013-01-01

    to a maximum of 14% (5%) for z > 6 (z > 7). The mean redshift of the host sample is assessed to be. Using this more complete sample, we confirm previous findings that the GRB rate at high redshift () appears to be in excess of predictions based on assumptions that it should follow conventional determinations...... of the star formation history of the universe, combined with an estimate of its likely metallicity dependence. This suggests that either star formation at high redshifts has been significantly underestimated, for example due to a dominant contribution from faint, undetected galaxies, or that GRB production...... is enhanced in the conditions of early star formation, beyond those usually ascribed to lower metallicity. © EAS, EDP Sciences 2013....

  20. Plasma Lactate Dehydrogenase Levels Predict Mortality in Acute Aortic Syndromes

    OpenAIRE

    Morello, Fulvio; Ravetti, Anna; Nazerian, Peiman; Liedl, Giovanni; Veglio, Maria Grazia; Battista, Stefania; Vanni, Simone; Pivetta, Emanuele; Montrucchio, Giuseppe; Mengozzi, Giulio; Rinaldi, Mauro; Moiraghi, Corrado; Lupia, Enrico

    2016-01-01

    Abstract In acute aortic syndromes (AAS), organ malperfusion represents a key event impacting both on diagnosis and outcome. Increased levels of plasma lactate dehydrogenase (LDH), a biomarker of malperfusion, have been reported in AAS, but the performance of LDH for the diagnosis of AAS and the relation of LDH with outcome in AAS have not been evaluated so far. This was a bi-centric prospective diagnostic accuracy study and a cohort outcome study. From 2008 to 2014, patients from 2 Emergency...

  1. Plasma IGFBP-2 levels after postoperative combined radiotherapy and chemotherapy predict prognosis in elderly glioblastoma patients.

    Directory of Open Access Journals (Sweden)

    Sheng Han

    Full Text Available It has been found that preoperative plasma IGFBP-2 levels correlate with prognosis in glioma patients. The prognostic value of plasma IGFBP-2 after postoperative combined radiotherapy and chemotherapy in glioma patients is unknown. Plasma IGFBP-2 levels in 83 glioblastoma patients after postoperative radiotherapy plus chemotherapy were analyzed using an IGFBP-2 ELISA kit. We found that after standard therapy plasma IGFBP-2 levels significantly correlated with the patient's age (R = 0.738, P<0.001 and Karnofsky performance status (KPS, R =  -0.633, P<0.05. Cox proportional hazards models were used to calculate hazard ratios (HRs of death according to plasma IGFBP-2 levels adjusted for patient clinical characteristics. Plasma IGFBP-2 levels significantly correlated with overall survival in glioblastoma patients (multivariate HR = 1.035; 95% CI, 1.024-1.047; P<0.001. The effect of plasma IGFBP-2 levels on survival seemed to differ according to patients' age. Among patients older than 60, high plasma IGFBP-2 levels were associated with a significant increase in overall mortality (HR = 1.097; 95% CI, 1.055-1.140; P<0.001. In contrast, plasma IGFBP-2 levels conferred no significant effect on mortality among patients younger than 60. Elevated plasma IGFBP-2 levels after combined postoperative radiotherapy and chemotherapy in elderly glioblastoma patients correlate with poor KPS score and predicts poor prognosis.

  2. Master Sintering Surface: A practical approach to its construction and utilization for Spark Plasma Sintering prediction

    Directory of Open Access Journals (Sweden)

    Pouchly V.

    2012-01-01

    Full Text Available The sintering is a complex thermally activated process, thus any prediction of sintering behaviour is very welcome not only for industrial purposes. Presented paper shows the possibility of densification prediction based on concept of Master Sintering Surface (MSS for pressure assisted Spark Plasma Sintering (SPS. User friendly software for evaluation of the MSS is presented. The concept was used for densification prediction of alumina ceramics sintered by SPS.

  3. High-redshift cosmography

    Energy Technology Data Exchange (ETDEWEB)

    Vitagliano, Vincenzo; Xia, Jun-Qing; Liberati, Stefano [SISSA, Via Beirut 2-4, 34151 Trieste (Italy); Viel, Matteo, E-mail: vitaglia@sissa.it, E-mail: xia@sissa.it, E-mail: liberati@sissa.it, E-mail: viel@oats.inaf.it [INFN sez. Trieste, Via Valerio 2, 34127 Trieste (Italy)

    2010-03-01

    We constrain the parameters describing the kinematical state of the universe using a cosmographic approach, which is fundamental in that it requires a very minimal set of assumptions (namely to specify a metric) and does not rely on the dynamical equations for gravity. On the data side, we consider the most recent compilations of Supernovae and Gamma Ray Bursts catalogues. This allows to further extend the cosmographic fit up to z = 6.6, i.e. up to redshift for which one could start to resolve the low z degeneracy among competing cosmological models. In order to reliably control the cosmographic approach at high redshifts, we adopt the expansion in the improved parameter y = z/(1+z). This series has the great advantage to hold also for z > 1 and hence it is the appropriate tool for handling data including non-nearby distance indicators. We find that Gamma Ray Bursts, probing higher redshifts than Supernovae, have constraining power and do require (and statistically allow) a cosmographic expansion at higher order than Supernovae alone. Exploiting the set of data from Union and GRBs catalogues, we show (for the first time in a purely cosmographic approach parametrized by deceleration q{sub 0}, jerk j{sub 0}, snap s{sub 0}) a definitively negative deceleration parameter q{sub 0} up to the 3σ confidence level. We present also forecasts for realistic data sets that are likely to be obtained in the next few years.

  4. High-Redshift Cosmography

    CERN Document Server

    Vitagliano, Vincenzo; Liberati, Stefano; Viel, Matteo

    2009-01-01

    We constrain the parameters describing the kinematical state of the universe using a cosmographic approach, which is fundamental in that it requires a very minimal set of assumptions (namely to specify a metric) and does not rely on the dynamical equations for gravity. On the data side, we consider the most recent compilations of Supernovae and Gamma Ray Bursts catalogs. This allows to further extend the cosmographic fit up to $z=6.6$, i.e. up to redshift for which one could start to resolve the low $z$ degeneracy among competing cosmological models. In order to reliably control the cosmographic approach at high redshifts, we adopt the expansion in the improved parameter $y=z/(1+z)$ (as proposed in Class. Quant. Grav., 24 (2007) 5985). This series has the great advantage to hold also for $z>1$ and hence it is the appropriate tool for handling data including non-nearby distance indicators. We find that Gamma Ray Bursts, probing higher redshifts than Supernovae, have constraining power and do require (and stati...

  5. Predictions of Alpha Heating in ITER L-mode and H-mode Plasmas

    Energy Technology Data Exchange (ETDEWEB)

    R.V. Budny

    2011-01-06

    Predictions of alpha heating in L-mode and H-mode DT plasmas in ITER are generated using the PTRANSP code. The baseline toroidal field of 5.3 T, plasma current ramped to 15 MA and a flat electron density profile ramped to Greenwald fraction 0.85 are assumed. Various combinations of external heating by negative ion neutral beam injection, ion cyclotron resonance, and electron cyclotron resonance are assumed to start half-way up the density ramp. The time evolution of plasma temperatures and, for some cases, toroidal rotation are predicted assuming GLF23 and boundary parameters. Significant toroidal rotation and flow-shearing rates are predicted by GLF23 even in the L-mode phase with low boundary temperatures, and the alpha heating power is predicted to be significant if the power threshold for the transition to H-mode is higher than the planned total heating power. The alpha heating is predicted to be 8-76 MW in L-mode at full density. External heating mixes with higher beam injection power have higher alpha heating power. Alternatively if the toroidal rotation is predicted assuming that the ratio of the momentum to thermal ion energy conductivity is 0.5, the flow-shearing rate is predicted to have insignificant effects on the GLF23- predicted temperatures, and alpha heating is predicted to be 8-20 MW. In H-mode plasmas the alpha heating is predicted to depend sensitively on the assumed pedestal temperatures. Cases with fusion gain greater than 10 are predicted to have alpha heating greater than 80 MW.

  6. Feature importance for machine learning redshifts applied to SDSS galaxies

    CERN Document Server

    Hoyle, Ben; Zitlau, Roman; Steiz, Stella; Weller, Jochen

    2014-01-01

    We present an analysis of importance feature selection applied to photometric redshift estimation using the machine learning architecture Random Decision Forests (RDF) with the ensemble learning routine Adaboost. We select a list of 85 easily measured (or derived) photometric quantities (or 'features') and spectroscopic redshifts for almost two million galaxies from the Sloan Digital Sky Survey Data Release 10. After identifying which features have the most predictive power, we use standard artificial Neural Networks (aNN) to show that the addition of these features, in combination with the standard magnitudes and colours, improves the machine learning redshift estimate by 18% and decreases the catastrophic outlier rate by 32%. We further compare the redshift estimate from RDF using the ensemble learning routine Adaboost with those from two different aNNs, and with photometric redshifts available from the SDSS. We find that the RDF requires orders of magnitude less computation time than the aNNs to obtain a m...

  7. Plasma Lactate Dehydrogenase Levels Predict Mortality in Acute Aortic Syndromes

    Science.gov (United States)

    Morello, Fulvio; Ravetti, Anna; Nazerian, Peiman; Liedl, Giovanni; Veglio, Maria Grazia; Battista, Stefania; Vanni, Simone; Pivetta, Emanuele; Montrucchio, Giuseppe; Mengozzi, Giulio; Rinaldi, Mauro; Moiraghi, Corrado; Lupia, Enrico

    2016-01-01

    Abstract In acute aortic syndromes (AAS), organ malperfusion represents a key event impacting both on diagnosis and outcome. Increased levels of plasma lactate dehydrogenase (LDH), a biomarker of malperfusion, have been reported in AAS, but the performance of LDH for the diagnosis of AAS and the relation of LDH with outcome in AAS have not been evaluated so far. This was a bi-centric prospective diagnostic accuracy study and a cohort outcome study. From 2008 to 2014, patients from 2 Emergency Departments suspected of having AAS underwent LDH assay at presentation. A final diagnosis was obtained by aortic imaging. Patients diagnosed with AAS were followed-up for in-hospital mortality. One thousand five hundred seventy-eight consecutive patients were clinically eligible, and 999 patients were included in the study. The final diagnosis was AAS in 201 (20.1%) patients. Median LDH was 424 U/L (interquartile range [IQR] 367–557) in patients with AAS and 383 U/L (IQR 331–460) in patients with alternative diagnoses (P < 0.001). Using a cutoff of 450 U/L, the sensitivity of LDH for AAS was 44% (95% confidence interval [CI] 37–51) and the specificity was 73% (95% CI 69–76). Overall in-hospital mortality for AAS was 23.8%. Mortality was 32.6% in patients with LDH ≥ 450 U/L and 16.8% in patients with LDH < 450 U/L (P = 0.006). Following stratification according to LDH quartiles, in-hospital mortality was 12% in the first (lowest) quartile, 18.4% in the second quartile, 23.5% in the third quartile, and 38% in the fourth (highest) quartile (P = 0.01). LDH ≥ 450 U/L was further identified as an independent predictor of death in AAS both in univariate and in stepwise logistic regression analyses (odds ratio 2.28, 95% CI 1.11–4.66; P = 0.025), in addition to well-established risk markers such as advanced age and hypotension. Subgroup analysis showed excess mortality in association with LDH ≥ 450 U/L in elderly, hemodynamically stable

  8. Plasma levels of catecholamines and asymmetric dimethylarginine levels as predictive values of mortality among hemodialysis patients

    Directory of Open Access Journals (Sweden)

    Dziedzic Marcin

    2014-06-01

    Full Text Available The aim of the study was to assess plasma concentration of catecholamines and asymmetric dimethyl arginine levels and a possible relationship to predict the mortality rates among hemodialysis patients. The study population comprised 27 subjects, aged 65-70 years. Each patient underwent dialysis thrice a week. Furthermore, the median duration of hemodialysis was 3.5 years. Based on the conducted research, it can be concluded that the concentrations of adrenaline and the level of asymmetric dimethylarginine have predictive value of mortality among hemodialysis patients. Of note, lowering plasma asymmetric dimethylarginine concentration may represent therapeutic target for prevention of progressive renal damage.

  9. Gyrokinetic simulations predict anomalous poloidal rotation in tokamak plasmas

    Science.gov (United States)

    Dif-Pradalier, Guilhem; Grandgirard, Virginie; Sarazin, Yanick; Garbet, Xavier; Ghendrih, Phillippe; Angelino, Paolo

    2008-11-01

    First-principle based collisionless gyrokinetic theory consensually provides today's deepest insight on turbulence-related problems in plasma physics. Conversely, neoclassical theory describes the effects of binary Coulomb collisions in a toroidal and inhomogeneous magnetic geometry and its consequences on particle trapping. The interplay between turbulence and collisions is a subject of great current focus for first-principle modeling since recent evidences have started to emphasise its relevance for the onset and the control of enhanced confinement regimes in the next-generation devices like Iter. A finite differences Fokker-Planck ion-ion collision operator is implemented in the full-f and global GYSELA code and has been thoroughly benchmarked in neoclassical regimes. Two types of simulations are compared, either purely neoclassical or turbulent including neoclassical effects. In each case, three different values of collisionality in the banana regime are investigated. Preliminary results show an enhancement of about 30% of the poloidal rotation of the main ions (Z=1) in the turbulent regime as compared to its neoclassical value. In all cases the radial force balance equation is satisfied within a few percent. Most of this increase comes from the radial electric field.

  10. Serum Creatinine Versus Plasma Methotrexate Levels to Predict Toxicities in Children Receiving High-dose Methotrexate.

    Science.gov (United States)

    Tiwari, Priya; Thomas, M K; Pathania, Subha; Dhawan, Deepa; Gupta, Y K; Vishnubhatla, Sreenivas; Bakhshi, Sameer

    2015-01-01

    Facilities for measuring methotrexate (MTX) levels are not available everywhere, potentially limiting administration of high-dose methotrexate (HDMTX). We hypothesized that serum creatinine alteration after HDMTX administration predicts MTX clearance. Overall, 122 cycles in 50 patients of non-Hodgkin lymphoma or acute lymphoblastic leukemia aged ≤18 years receiving HDMTX were enrolled prospectively. Plasma MTX levels were measured at 12, 24, 36, 48, 60, and 72 hours; serum creatinine was measured at baseline, 24, 48, and 72 hours. Correlation of plasma MTX levels with creatinine levels and changes in creatinine from baseline (Δ creatinine) were evaluated. Plasma MTX levels at 72 hours showed positive correlation with serum creatinine at 48 hours (P = .011) and 72 hours (P = .013) as also Δ creatinine at 48 hours (P = .042) and 72 hours (P = .045). However, cut-off value of either creatinine or Δ creatinine could not be established to reliably predict delayed MTX clearance. Greater than 50% Δ creatinine at 48 and 72 hours significantly predicted grade 3/4 leucopenia (P = .036 and P = .001, respectively) and thrombocytopenia (P = .012 and P = .009, respectively) but not mucositis (P = .827 and P = .910, respectively). Delayed MTX elimination did not predict any grade 3/4 toxicity. In spite of demonstration of significant correlation between serum creatinine and Δ creatinine with plasma MTX levels at 72 hours, cut-off value of either variable to predict MTX delay could not be established. Thus, either of these cannot be used as a surrogate for plasma MTX estimation. Interestingly, Δ creatinine effectively predicted hematological toxicities, which were not predicted by delayed MTX clearance.

  11. The redshift number density evolution of Mg Ⅱ absorption systems

    Institute of Scientific and Technical Information of China (English)

    Zhi-Fu Chen

    2013-01-01

    We make use of the recent large sample of 17 042 Mg Ⅱ absorption systems from Quider et al.to analyze the evolution of the redshift number density.Regardless of the strength of the absorption line,we find that the evolution of the redshift number density can be clearly distinguished into three different phases.In the intermediate redshift epoch (0.6 ≤ z ≤ 1.6),the evolution of the redshift number density is consistent with the non-evolution curve,however,the non-evolution curve over-predicts the values of the redshift number density in the early (z ≤ 0.6) and late (z ≥ 1.6) epochs.Based on the invariant cross-section of the absorber,the lack of evolution in the redshift number density compared to the non-evolution curve implies the galaxy number density does not evolve during the middle epoch.The fiat evolution of the redshift number density tends to correspond to a shallow evolution in the galaxy merger rate during the late epoch,and the steep decrease of the redshift number density might be ascribed to the small mass of halos during the early epoch.

  12. Photometric redshifts for the NGVS

    Science.gov (United States)

    Raichoor, A.; Mei, S.; Erben, T.; Hildebrandt, H.; Huertas-Company, M.; Ilbert, O.; Licitra, R.; Ball, N. M.; Boissier, S.; Boselli, A.; Chen, Y.-T.; Côté, P.; Cuillandre, J.-C.; Duc, P. A.; Durrell, P. R.; Ferrarese, L.; Guhathakurta, P.; Gwyn, S. D. J.; Kavelaars, J. J.; Lancon, A.; Liu, C.; MacArthur, L. A.; Muller, M.; Muñoz, R. P.; Peng, E. W.; Puzia, T. H.; Sawicki, M.; Toloba, E.; Van Waerbeke, L.; Woods, D.; Zhang, H.

    2014-12-01

    We present the photometric redshift catalog for the Next Generation Virgo Cluster Survey (NGVS), a 104 deg^2 optical imaging survey centered on the Virgo cluster in the u^*, g, r ,i, z bandpasses at point source depth of 25-26 ABmag. It already is the new optical reference survey for the study of the Virgo cluster, and will be also used for multiple ancillary programs. To obtain photometric redshifts, we perform accurate photometry, through the PSF-homogenization of our data. We then estimate the photometric redshifts using Le Phare and BPZ codes, adding a new prior extended down to i_{AB}=12.5 mag. We assess the accuracy of our photometric redshifts as a function of magnitude and redshift using ˜80,000 spectroscopic redshifts from public surveys. For i_{AB} outliers.

  13. High redshift blazars

    CERN Document Server

    Ghisellini, G

    2013-01-01

    Blazars are sources whose jet is pointing to us. Since their jets are relativistic, the flux is greatly amplified in the direction of motion, making blazars the most powerful persistent objects in the Universe. This is true at all frequencies, but especially where their spectrum peaks. Although the spectrum of moderate powerful sources peaks in the ~GeV range, extremely powerful sources at high redshifts peak in the ~MeV band. This implies that the hard X-ray band is the optimal one to find powerful blazars beyond a redshift of ~4. First indications strongly suggest that powerful high-z blazars harbor the most massive and active early black holes, exceeding a billion solar masses. Since for each detected blazars there must exist hundreds of similar, but misaligned, sources, the search for high-z blazars is becoming competitive with the search of early massive black holes using radio-quiet quasars. Finding how the two populations of black holes (one in jetted sources, the other in radio-quiet objects) evolve i...

  14. Getting started With Amazon Redshift

    CERN Document Server

    Bauer, Stefan

    2013-01-01

    Getting Started With Amazon Redshift is a step-by-step, practical guide to the world of Redshift. Learn to load, manage, and query data on Redshift.This book is for CIOs, enterprise architects, developers, and anyone else who needs to get familiar with RedShift. The CIO will gain an understanding of what their technical staff is working on; the technical implementation personnel will get an in-depth view of the technology, and what it will take to implement their own solutions.

  15. Value of plasma ADMA in predicting cardiac structure and function of patients with chronic kidney diseases

    Institute of Scientific and Technical Information of China (English)

    叶建华

    2012-01-01

    Objective To explore the predicting value of plasma asymmetric dimethylarginine (ADMA) in cardiac structure and function of patients with chronic kidney diseases(CKD). Methods A total of 100 CKD patients were enrolled in this cross-sectional study. According to staging of the

  16. Predictive value of plasma hCG measured 14 days after Day-2 single embryo transfer

    DEFF Research Database (Denmark)

    Løssl, Kristine; Oldenburg, Anna; Toftager, Mette

    2017-01-01

    INTRODUCTION: Prediction of pregnancy outcome after IVF is important for patients and clinicians. Early plasma hCG (p-hCG) levels are the best known predictor of pregnancy outcome, but no studies has been restricted to single embryo transfer (SET) of Day-2 embryos. The aim of the present study...

  17. Sky Mining - Application to Photomorphic Redshift Estimation

    Science.gov (United States)

    Nayak, Pragyansmita

    severity every day, alternative method "Photometric redshift" has been studied in the past. It uses the brightness of the object viewed through various standard filters, each of which lets through a relatively broad spectrum of colors. However, these methods are bound by the degeneracy problem (objects with different color profiles have the same redshift) which leads to low predictive accuracy. As part of our study, we are looking beyond color attributes to identify other measured attributes as degeneracy resolvers as well as generate estimators that are highly accurate; termed as "Photomorphic redshift" estimators. The present study investigates the photometric information of the objects such as color and magnitude (= observed flux) and morphology attributes such as shape, size, orientation and concentration in the different wavelengths. The specific type of magnitude used in this study are the PSF, Fiber and Petrosian magnitude. The morphology attributes are the ratio of Fiber to Petrosian magnitude, concentration index and Petrosian radius. All these attributes are in the five bands ugriz of the Sloan Digital Sky Survey (SDSS). Machine learning techniques based on Naive Bayes (NB), Bayesian Network (BN) and Generalized Linear Model (GLM) are researched to better understand their applicability, advantages and resulting predictive performance in terms of efficiency and accuracy. Note: The SDSS Data Release (DR) 10 data was used in the executed experiments (total of 700,777 galaxies with forty-five attributes associated with each galaxy). The significant findings of the present work are as follows: 1. Magnitude and morphology attributes have been found to be successful degeneracy resolvers. 2. Magnitude and morphology attributes have been found to be better redshift estimators than color attributes alone. 3. Naive Bayes, Bayesian Network and GLM have been found to be viable redshift estimation methods. Attribute selection is an important factor in computational performance

  18. Tuning target selection algorithms to improve galaxy redshift estimates

    CERN Document Server

    Hoyle, Ben; Rau, Markus Michael; Seitz, Stella; Weller, Jochen

    2015-01-01

    We showcase machine learning (ML) inspired target selection algorithms to determine which of all potential targets should be selected first for spectroscopic follow up. Efficient target selection can improve the ML redshift uncertainties as calculated on an independent sample, while requiring less targets to be observed. We compare the ML targeting algorithms with the Sloan Digital Sky Survey (SDSS) target order, and with a random targeting algorithm. The ML inspired algorithms are constructed iteratively by estimating which of the remaining target galaxies will be most difficult for the machine learning methods to accurately estimate redshifts using the previously observed data. This is performed by predicting the expected redshift error and redshift offset (or bias) of all of the remaining target galaxies. We find that the predicted values of bias and error are accurate to better than 10-30% of the true values, even with only limited training sample sizes. We construct a hypothetical follow-up survey and fi...

  19. Measuring photometric redshifts using galaxy images and Deep Neural Networks

    Science.gov (United States)

    Hoyle, B.

    2016-07-01

    We propose a new method to estimate the photometric redshift of galaxies by using the full galaxy image in each measured band. This method draws from the latest techniques and advances in machine learning, in particular Deep Neural Networks. We pass the entire multi-band galaxy image into the machine learning architecture to obtain a redshift estimate that is competitive, in terms of the measured point prediction metrics, with the best existing standard machine learning techniques. The standard techniques estimate redshifts using post-processed features, such as magnitudes and colours, which are extracted from the galaxy images and are deemed to be salient by the user. This new method removes the user from the photometric redshift estimation pipeline. However we do note that Deep Neural Networks require many orders of magnitude more computing resources than standard machine learning architectures, and as such are only tractable for making predictions on datasets of size ≤50k before implementing parallelisation techniques.

  20. Plasma calprotectin predicts mortality in patients with ST segment elevation myocardial infarction treated with primary percutaneous coronary intervention

    DEFF Research Database (Denmark)

    Jensen, Louise J N; Haahr-Pedersen, Sune Ammentorp; Bjerre, Mette

    2010-01-01

    We investigated the predictive value of plasma calprotectin levels for mortality in patients with ST segment elevation myocardial infarction (STEMI) successfully treated with primary percutaneous coronary intervention (pPCI).......We investigated the predictive value of plasma calprotectin levels for mortality in patients with ST segment elevation myocardial infarction (STEMI) successfully treated with primary percutaneous coronary intervention (pPCI)....

  1. The Highest Redshift Radio Galaxies

    CERN Document Server

    Van Breugel, W

    2000-01-01

    At low redshifts powerful radio sources are uniquely associated with massive galaxies, and are thought to be powered by supermassive black holes. Modern 8m -- 10m telescopes may be used used to find their likely progenitors at very high redshifts to study their formation and evolution.

  2. Overconfidence in Photometric Redshift Estimation

    CERN Document Server

    Wittman, David; Tobin, Ryan

    2016-01-01

    We describe a new test of photometric redshift performance given a spectroscopic redshift sample. This test complements the traditional comparison of redshift {\\it differences} by testing whether the probability density functions $p(z)$ have the correct {\\it width}. We test two photometric redshift codes, BPZ and EAZY, on each of two data sets and find that BPZ is consistently overconfident (the $p(z)$ are too narrow) while EAZY produces approximately the correct level of confidence. We show that this is because EAZY models the uncertainty in its spectral energy distribution templates, and that post-hoc smoothing of the BPZ $p(z)$ provides a reasonable substitute for detailed modeling of template uncertainties. Either remedy still leaves a small surplus of galaxies with spectroscopic redshift very far from the peaks. Thus, better modeling of low-probability tails will be needed for high-precision work such as dark energy constraints with the Large Synoptic Survey Telescope and other large surveys.

  3. Metabolism of Oxycodone in Human Hepatocytes from Different Age Groups and Prediction of Hepatic Plasma Clearance

    Science.gov (United States)

    Korjamo, Timo; Tolonen, Ari; Ranta, Veli-Pekka; Turpeinen, Miia; Kokki, Hannu

    2012-01-01

    Oxycodone is commonly used to treat severe pain in adults and children. It is extensively metabolized in the liver in adults, but the maturation of metabolism is not well understood. Our aim was to study the metabolism of oxycodone in cryopreserved human hepatocytes from different age groups (3 days, 2 and 5 months, 4 years, adult pool) and predict hepatic plasma clearance of oxycodone using these data. Oxycodone (0.1, 1, and 10 μM) was incubated with hepatocytes for 4 h, and 1 μM oxycodone also with CYP3A inhibitor ketoconazole (1 μM). Oxycodone and noroxycodone concentrations were determined at several time points with liquid chromatography–mass spectrometry. In vitro clearance of oxycodone was used to predict hepatic plasma clearance, using the well-stirred model and published physiological parameters. Noroxycodone was the major metabolite in all batches and ketoconazole inhibited the metabolism markedly in most cases. A clear correlation between in vitro oxycodone clearance and CYP3A4 activity was observed. The predicted hepatic plasma clearances were typically much lower than the published median total plasma clearance from pharmacokinetic studies. The data suggests that there are no children-specific metabolites of oxycodone. Moreover, CYP3A activity seems to be the major determinant in metabolic clearance of oxycodone regardless of age group or individual variability in hepatocyte batches. PMID:22291644

  4. Tuning target selection algorithms to improve galaxy redshift estimates

    Science.gov (United States)

    Hoyle, Ben; Paech, Kerstin; Rau, Markus Michael; Seitz, Stella; Weller, Jochen

    2016-06-01

    We showcase machine learning (ML) inspired target selection algorithms to determine which of all potential targets should be selected first for spectroscopic follow-up. Efficient target selection can improve the ML redshift uncertainties as calculated on an independent sample, while requiring less targets to be observed. We compare seven different ML targeting algorithms with the Sloan Digital Sky Survey (SDSS) target order, and with a random targeting algorithm. The ML inspired algorithms are constructed iteratively by estimating which of the remaining target galaxies will be most difficult for the ML methods to accurately estimate redshifts using the previously observed data. This is performed by predicting the expected redshift error and redshift offset (or bias) of all of the remaining target galaxies. We find that the predicted values of bias and error are accurate to better than 10-30 per cent of the true values, even with only limited training sample sizes. We construct a hypothetical follow-up survey and find that some of the ML targeting algorithms are able to obtain the same redshift predictive power with 2-3 times less observing time, as compared to that of the SDSS, or random, target selection algorithms. The reduction in the required follow-up resources could allow for a change to the follow-up strategy, for example by obtaining deeper spectroscopy, which could improve ML redshift estimates for deeper test data.

  5. Preoperative plasma leptin levels predict delirium in elderly patients after hip fracture surgery.

    Science.gov (United States)

    Chen, Xue-Wu; Shi, Jun-Wu; Yang, Ping-Shan; Wu, Zhu-Qi

    2014-07-01

    Leptin is considered to be a modulator of the immune response. Hypoleptinemia increases the risk for Alzheimer's disease and vascular dementia. The present study aimed to investigate the ability of plasma leptin level to predict delirium in elderly patients after hip fracture surgery. Postoperative delirium (pod) was evaluated using the Confusion Assessment Method. Prolonged postoperative delirium (ppod) was defined as delirium lasting more than 4 weeks. Plasma leptin levels of 186 elderly patients and 186 elderly controls were measured by an enzyme-linked immunosorbent assay. Plasma leptin level was substantially lower in patients than in controls (4.6±2.2ng/ml vs. 7.5±1.8ng/ml, Pdelirium and also prolonged delirium in elderly patients after hip fracture surgery.

  6. Plasma sCD14 as a biomarker to predict pulmonary exacerbations in cystic fibrosis.

    Directory of Open Access Journals (Sweden)

    Bradley S Quon

    Full Text Available BACKGROUND: One in four cystic fibrosis (CF patients diagnosed with a pulmonary exacerbation will not recover their baseline lung function despite standard treatment. This highlights the importance of preventing such events. Clinical decision-making can be improved through a simple blood test that predicts individuals at elevated short-term risk of an exacerbation. METHODS: We obtained plasma samples from 30 stable CF patients from the St. Paul's Hospital Adult CF Clinic (Vancouver, Canada. For 15 patients, an additional plasma sample was obtained during an exacerbation. Soluble CD14 (sCD14 and C-reactive protein (CRP were quantified using ELISA kits. Myeloperoxidase (MPO, interleukin(IL-6, IL-1β, monocyte chemoattractant protein-1 (MCP-1, vascular endothelial growth factor (VEGF, and granulocyte colony-stimulating factor (G-CSF were quantified using Luminex™ immunoassays. Stable state biomarker levels were examined in their ability to predict individuals that would experience a pulmonary exacerbation requiring intravenous (IV antibiotics within 4 months. Paired stable and exacerbation plasma biomarker levels were also compared. RESULTS: sCD14 levels were significantly higher in patients that experienced a pulmonary exacerbation requiring IV antibiotics within 4 months (p = 0.001. sCD14 cut-off value of 1450 ng/mL was associated with an area under the curve of 0.91 (95% CI 0.83-0.99 for predicting an exacerbation within 4 months of a stable visit, with a sensitivity of 100% and specificity of 82%. Plasma sCD14 levels were significantly higher during exacerbations than during periods of clinical stability (p = 0.03. CONCLUSIONS: Plasma sCD14 is a promising biomarker for identifying CF patients who will exacerbate within 4 months of a stable visit but requires further study in larger, independent cohorts.

  7. Bayesian redshift-space distortions correction from galaxy redshift surveys

    CERN Document Server

    Kitaura, Francisco-Shu; Angulo, Raul E; Chuang, Chia-Hsun; Rodriguez-Torres, Sergio; Monteagudo, Carlos Hernandez; Prada, Francisco; Yepes, Gustavo

    2015-01-01

    We present a Bayesian reconstruction method which maps a galaxy distribution from redshift-space to real-space inferring the distances of the individual galaxies. The method is based on sampling density fields assuming a lognormal prior with a likelihood given by the negative binomial distribution function modelling stochastic bias. We assume a deterministic bias given by a power law relating the dark matter density field to the expected halo or galaxy field. Coherent redshift-space distortions are corrected in a Gibbs-sampling procedure by moving the galaxies from redshift-space to real-space according to the peculiar motions derived from the recovered density field using linear theory with the option to include tidal field corrections from second order Lagrangian perturbation theory. The virialised distortions are corrected by sampling candidate real-space positions (being in the neighbourhood of the observations along the line of sight), which are compatible with the bulk flow corrected redshift-space posi...

  8. Comprehensive microstructural characterization and predictive property modeling of plasma-sprayed zirconia coatings

    Energy Technology Data Exchange (ETDEWEB)

    Kulkarni, A.; Wang, Z.; Nakamura, T.; Sampath, S.; Goland, A.; Herman, H.; Allen, J.; Ilavsky, J.; Long, G.; Frahm, J.; Steinbrech, R.W

    2003-05-23

    Quantitative microstructure characterization to better understand processing-microstructure-property correlations is of considerable interest in plasma sprayed coating research. This paper quantifies, by means of small-angle neutron scattering (SANS) data, microstructure (porosity, opening dimensions, orientation and morphologies) in plasma sprayed partially-stabilized zirconia (PSZ) coatings, primarily used as thermal barrier coatings. We report on the investigation of the influence of feedstock characteristics on microstructure and establish its influence on the resultant thermal and mechanical properties. The microstructural parameters determined by SANS studies are then assembled into a preliminary model to develop a predictive capability for estimating the properties of these coatings. Thermal conductivity and elastic modulus were predicted using finite element analysis and ultimately compared to experimental values.

  9. Plasma sCD14 as a Biomarker to Predict Pulmonary Exacerbations in Cystic Fibrosis

    OpenAIRE

    Quon, Bradley S.; Ngan, David A.; Wilcox, Pearce G; S F Paul Man; Don D Sin

    2014-01-01

    BACKGROUND: One in four cystic fibrosis (CF) patients diagnosed with a pulmonary exacerbation will not recover their baseline lung function despite standard treatment. This highlights the importance of preventing such events. Clinical decision-making can be improved through a simple blood test that predicts individuals at elevated short-term risk of an exacerbation. METHODS: We obtained plasma samples from 30 stable CF patients from the St. Paul's Hospital Adult CF Clinic (Vancouver, Canada)....

  10. ELM-KNN for photometric redshift estimation of quasars

    Science.gov (United States)

    Zhang, Yanxia; Tu, Yang; Zhao, Yongheng; Tian, Haijun

    2017-06-01

    We explore photometric redshift estimation of quasars with the SDSS DR12 quasar sample. Firstly the quasar sample is separated into three parts according to different redshift ranges. Then three classifiers based on Extreme Learning Machine (ELM) are created in the three redshift ranges. Finally k-Nearest Neighbor (kNN) approach is applied on the three samples to predict photometric redshifts of quasars with multiwavelength photometric data. We compare the performance with different input patterns by ELM-KNN with that only by kNN. The experimental results show that ELM-KNN is feasible and superior to kNN (e.g. rms is 0.0751 vs. 0.2626 for SDSS sample), in other words, the ensemble method has the potential to increase regressor performance beyond the level reached by an individual regressor alone and will be a good choice when facing much more complex data.

  11. Modelling multimodal photometric redshift regression with noisy observations

    CERN Document Server

    Kügler, S D

    2016-01-01

    In this work, we are trying to extent the existing photometric redshift regression models from modeling pure photometric data back to the spectra themselves. To that end, we developed a PCA that is capable of describing the input uncertainty (including missing values) in a dimensionality reduction framework. With this "spectrum generator" at hand, we are capable of treating the redshift regression problem in a fully Bayesian framework, returning a posterior distribution over the redshift. This approach allows therefore to approach the multimodal regression problem in an adequate fashion. In addition, input uncertainty on the magnitudes can be included quite naturally and lastly, the proposed algorithm allows in principle to make predictions outside the training values which makes it a fascinating opportunity for the detection of high-redshifted quasars.

  12. Multi-parameter estimating photometric redshifts with artificial neural networks

    CERN Document Server

    Li, L; Zhao, Y; Yang, D; Li, Lili; Zhang, Yanxia; Zhao, Yongheng; Yang, Dawei

    2006-01-01

    We calculate photometric redshifts from the Sloan Digital Sky Survey Data Release 2 Galaxy Sample using artificial neural networks (ANNs). Different input patterns based on various parameters (e.g. magnitude, color index, flux information) are explored and their performances for redshift prediction are compared. For ANN technique, any parameter may be easily incorporated as input, but our results indicate that using reddening magnitude produces photometric redshift accuracies often better than the Petrosian magnitude or model magnitude. Similarly, the model magnitude is also superior to Petrosian magnitude. In addition, ANNs also show better performance when the more effective parameters increase in the training set. Finally, the method is tested on a sample of 79, 346 galaxies from the SDSS DR2. When using 19 parameters based on the reddening magnitude, the rms error in redshift estimation is sigma(z)=0.020184. The ANN is highly competitive tool when compared with traditional template-fitting methods where a...

  13. Very high redshift radio galaxies

    Energy Technology Data Exchange (ETDEWEB)

    van Breugel, W.J.M., LLNL

    1997-12-01

    High redshift radio galaxies (HzRGs) provide unique targets for the study of the formation and evolution of massive galaxies and galaxy clusters at very high redshifts. We discuss how efficient HzRG samples ae selected, the evidence for strong morphological evolution at near-infracd wavelengths, and for jet-induced star formation in the z = 3 800 HzRG 4C41 17

  14. Atom gravimeters and gravitational redshift

    CERN Document Server

    Wolf, Peter; Borde, Christian J; Reynaud, Serge; Salomon, Christophe; Cohen-Tannoudji, Claude; 10.1038/nature09340

    2010-01-01

    In a recent paper, H. Mueller, A. Peters and S. Chu [A precision measurement of the gravitational redshift by the interference of matter waves, Nature 463, 926-929 (2010)] argued that atom interferometry experiments published a decade ago did in fact measure the gravitational redshift on the quantum clock operating at the very high Compton frequency associated with the rest mass of the Caesium atom. In the present Communication we show that this interpretation is incorrect.

  15. EXTENDED PHOTOMETRY FOR THE DEEP2 GALAXY REDSHIFT SURVEY: A TESTBED FOR PHOTOMETRIC REDSHIFT EXPERIMENTS

    Energy Technology Data Exchange (ETDEWEB)

    Matthews, Daniel J.; Newman, Jeffrey A. [Department of Physics and Astronomy, University of Pittsburgh, 3941 O' Hara Street, Pittsburgh, PA 15260 (United States); Coil, Alison L. [Department of Physics, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 (United States); Cooper, Michael C. [Center for Galaxy Evolution, Department of Physics and Astronomy, University of California, Irvine, 4129 Frederick Reines Hall, Irvine, CA 92697 (United States); Gwyn, Stephen D. J., E-mail: djm70@pitt.edu, E-mail: janewman@pitt.edu, E-mail: acoil@ucsd.edu, E-mail: m.cooper@uci.edu, E-mail: Stephen.Gwyn@nrc-cnrc.gc.ca [Canadian Astronomical Data Centre, Herzberg Institute of Astrophysics, 5071 West Saanich Road, Victoria, British Columbia V9E 2E7 (Canada)

    2013-02-15

    This paper describes a new catalog that supplements the existing DEEP2 Galaxy Redshift Survey photometric and spectroscopic catalogs with ugriz photometry from two other surveys: the Canada-France-Hawaii Legacy Survey (CFHTLS) and the Sloan Digital Sky Survey (SDSS). Each catalog is cross-matched by position on the sky in order to assign ugriz photometry to objects in the DEEP2 catalogs. We have recalibrated the CFHTLS photometry where it overlaps DEEP2 in order to provide a more uniform data set. We have also used this improved photometry to predict DEEP2 BRI photometry in regions where only poorer measurements were available previously. In addition, we have included improved astrometry tied to SDSS rather than USNO-A2.0 for all DEEP2 objects. In total this catalog contains {approx}27, 000 objects with full ugriz photometry as well as robust spectroscopic redshift measurements, 64% of which have r > 23. By combining the secure and accurate redshifts of the DEEP2 Galaxy Redshift Survey with ugriz photometry, we have created a catalog that can be used as an excellent testbed for future photo-z studies, including tests of algorithms for surveys such as LSST and DES.

  16. The Redshift of GRB 970508

    CERN Document Server

    Reichart, D E

    1997-01-01

    GRB 970508 is the second gamma-ray burst (GRB) for which an optical afterglow has been detected. It is the first GRB for which a distance scale has been determined: absorption and emission features in spectra of the optical afterglow place GRB 970508 at a redshift of z >= 0.835 (Metzger et al. 1997a, 1997b). The lack of a Lyman-alpha forest in these spectra further constrains this redshift to be less than approximately 2.3. I show that the spectrum of the optical afterglow of GRB 970508, once corrected for Galactic absorption, is inconsistent with the relativistic blast-wave model unless a second, redshifted source of extinction is introduced. This second source of extinction may be the yet unobserved host galaxy. I determine its redshift to be z = 1.09^{+0.14}_{-0.41}, which is consistent with the observed redshift of z = 0.835. Redshifts greater than z = 1.40 are ruled out at the 3 sigma confidence level.

  17. Plasma lipidomic profiling of treated HIV-positive individuals and the implications for cardiovascular risk prediction.

    Science.gov (United States)

    Wong, Gerard; Trevillyan, Janine M; Fatou, Benoit; Cinel, Michelle; Weir, Jacquelyn M; Hoy, Jennifer F; Meikle, Peter J

    2014-01-01

    The increased risk of coronary artery disease in human immunodeficiency virus (HIV) positive patients is collectively contributed to by the human immunodeficiency virus and antiretroviral-associated dyslipidaemia. In this study, we investigate the characterisation of the plasma lipid profiles of treated HIV patients and the relationship of 316 plasma lipid species across multiple lipid classes with the risk of future cardiovascular events in HIV-positive patients. In a retrospective case-control study, we analysed plasma lipid profiles of 113 subjects. Cases (n = 23) were HIV-positive individuals with a stored blood sample available 12 months prior to their diagnosis of coronary artery disease (CAD). They were age and sex matched to HIV-positive individuals without a diagnosis of CAD (n = 45) and with healthy HIV-negative volunteers (n = 45). Association of plasma lipid species and classes with HIV infection and cardiovascular risk in HIV were determined. In multiple logistic regression, we identified 83 lipids species and 7 lipid classes significantly associated with HIV infection and a further identified 74 lipid species and 8 lipid classes significantly associated with future cardiovascular events in HIV-positive subjects. Risk prediction models incorporating lipid species attained an area under the receiver operator characteristic curve (AUC) of 0.78 (0.775, 0.785)) and outperformed all other tested markers and risk scores in the identification of HIV-positive subjects with increased risk of cardiovascular events. Our results demonstrate that HIV-positive patients have significant differences in their plasma lipid profiles compared with healthy HIV-negative controls and that numerous lipid species were significantly associated with elevated cardiovascular risk. This suggests a potential novel application for plasma lipids in cardiovascular risk screening of HIV-positive patients.

  18. Life Prediction of Atmospheric Plasma-Sprayed Thermal Barrier Coatings Using Temperature-Dependent Model Parameters

    Science.gov (United States)

    Zhang, B.; Chen, Kuiying; Baddour, N.; Patnaik, P. C.

    2017-06-01

    The failure analysis and life prediction of atmospheric plasma-sprayed thermal barrier coatings (APS-TBCs) were carried out for a thermal cyclic process. A residual stress model for the top coat of APS-TBC was proposed and then applied to life prediction. This residual stress model shows an inversion characteristic versus thickness of thermally grown oxide. The capability of the life model was demonstrated using temperature-dependent model parameters. Using existing life data, a comparison of fitting approaches of life model parameters was performed. A larger discrepancy was found for the life predicted using linearized fitting parameters versus temperature compared to those using non-linear fitting parameters. A method for integrating the residual stress was proposed by using the critical time of stress inversion. The role of the residual stresses distributed at each individual coating layer was explored and their interplay on the coating's delamination was analyzed.

  19. The Plasma Depletion Layer Beyond the Heliopause: Evidence, Implications, and Predictions for Voyager 2

    Science.gov (United States)

    Cairns, I. H.; Fuselier, S. A.

    2015-12-01

    A plasma depletion layer (PDL) is predicted beyond the heliopause, analogous to the PDLs observed sunwards of the magnetopauses of Earth, Mercury, Jupiter, and Saturn. The physics is that draping of interstellar (ISM) magnetic field lines over the heliopause should increase the magnetic field strength (and so the perpendicular ion temperature), cause density depletions by allowing plasma ions (and electrons) with large parallel temperatures to escape along the field, and increase the perpendicular to parallel temperature anisotropy until limited by wave instabilities. It is argued that published Voyager 1 magnetometer and plasma wave data beyond the heliopause provide strong evidence for the magnetic field amplification (by ≈ 30%) and density depletion (by ≈ 50%) expected for the PDL. The predicted reduction in parallel temperature is ≈ 50%. Using the ISM magnetic field direction obtained from the centroid of the IBEX Ribbon, the orientation of the PDL and the associated locations on the heliopause of the points of maximum magnetic field draping and maximum total pressure are predicted. It is observed that the IBEX Ribbon overlies the former while the latter lies within the ridge of maximum non-Ribbon ENA flux. The PDL should be strongest along the ISM field line passing through these points and the nominal Sun-ISM velocity vector. It is predicted that Voyager 2 lies within 5 degrees (≈ 10 AU) of the strong PDL region while Voyager 1 is over 15 degrees (≈ 35 AU) away. Thus Voyager 2 should observe a much stronger PDL (stronger magnetic field amplification, density depletions, and reductions in parallel temperature) than Voyager 1. Finally, the reduced cosmic ray fluxes observed near 90 degree pitchangle by Voyager 1 beyond the heliopause may be explained qualitatively in terms of magnetic focusing as cosmic rays propagate away from the stronger field regions of the PDL and magnetic draping region on the heliopause, assuming isotropic cosmic rays at the

  20. ANN-based wear performance prediction for plasma nitrided Ti6Al4V alloy

    Energy Technology Data Exchange (ETDEWEB)

    Kahraman, Fatih; Karadeniz, Sueleyman; Durmus, Izmir; Durmus, Huelya

    2012-07-01

    Surface modification of a Ti6Al4V titanium alloy was made by the plasma nitriding process. Plasma nitriding was performed in a constant gas mixture of 20% H{sub 2} -80% N{sub 2} at temperatures between 700 and 1000 C and process times between 2 and 15 h. Samples nitrided at different treatment times and temperatures were subjected to the dry sliding wear test using the pin-on-disc set up under 80N normal load with rotational speed of counter face disc of 0.8 m/s at room conditions. An artificial neural network (ANN) model of was developed for prediction of wear performance of the plasma nitrided Ti6Al4V alloy. The inputs of the ANN model were processing times and temperatures, diffusion layer thickness, Ti{sub 2}N thickness, TiN thickness and hardness. The output of the ANN model was wear loss. The model is based on the multilayer backpropagation neural technique. The ANN was trained with a comprehensive dataset collected from experimental conditions and results of authors. The model can be used for the prediction of wear properties of Ti6Al4V alloys nitrided at different parameters. The ANN model demonstrated the best statistical performance with the experimental results.

  1. Prediction and optimization of the recovery rate in centrifugal separation of platelet-rich plasma (PRP)

    Science.gov (United States)

    Piao, Linfeng; Park, Hyungmin; Jo, Chris

    2016-11-01

    We present a theoretical model of the recovery rate of platelet and white blood cell in the process of centrifugal separation of platelet-rich plasma (PRP). For the practically used conditions in the field, the separation process is modeled as a one-dimensional particle sedimentation; a quasi-linear partial differential equation is derived based on the kinematic-wave theory. This is solved to determine the interface positions between supernatant-suspension and suspension-sediment, used to estimate the recovery rate of the plasma. While correcting the Brown's hypothesis (1989) claiming that the platelet recovery is linearly proportional to that of plasma, we propose a new correlation model for prediction of the platelet recovery, which is a function of the volume of whole blood, centrifugal acceleration and time. For a range of practical parameters, such as hematocrit, volume of whole blood and centrifugation (time and acceleration), the predicted recovery rate shows a good agreement with available clinical data. We propose that this model is further used to optimize the preparation method of PRP that satisfies the customized case. Supported by a Grant (MPSS-CG-2016-02) through the Disaster and Safety Management Institute funded by Ministry of Public Safety and Security of Korean government.

  2. Toxicity challenges in environmental chemicals: Prediction of human plasma protein binding through quantitative structure-activity relationship (QSAR) models

    Science.gov (United States)

    The present study explores the merit of utilizing available pharmaceutical data to construct a quantitative structure-activity relationship (QSAR) for prediction of the fraction of a chemical unbound to plasma protein (Fub) in environmentally relevant compounds. Independent model...

  3. New Approaches To Photometric Redshift Prediction

    Data.gov (United States)

    National Aeronautics and Space Administration — Expanding upon the work of Way & Srivastava (2006) we demonstrate how the use of training sets of comparable size continue to make Gaussian Process Regression a...

  4. Reliable test for prenatal prediction of fetal RhD type using maternal plasma from RhD negative women

    DEFF Research Database (Denmark)

    Clausen, Frederik Banch; Krog, Grethe Risum; Rieneck, Klaus;

    2005-01-01

    The objective of this study was to establish a reliable test for prenatal prediction of fetal RhD type using maternal plasma from RhD negative women. This test is needed for future prenatal Rh prophylaxis.......The objective of this study was to establish a reliable test for prenatal prediction of fetal RhD type using maternal plasma from RhD negative women. This test is needed for future prenatal Rh prophylaxis....

  5. Electric Field Prediction using Micro-plasma Inside a Microwave Cavity for Soot Oxidation

    Directory of Open Access Journals (Sweden)

    Al-Wakeel Haitham B.

    2014-07-01

    Full Text Available The reduction of the harmful emission soot is necessary in recent years due to the environmental protection regulation. Soot is a carbonaceous matter and a strong absorber of microwave energy. Microwave heating offers the advantage over conventional heating to oxide soot. Where plasma is high electric field that leads to instantaneous temperature rising. This paper proposes a recent concept for soot oxidation using micro-plasma in a microwave cavity. The concept was presented by simulating the electric field using microwave heating and thin metal object. Five cases were examined numerically in a mono-mode TE10 microwave cavity WR430 having closed surfaces of perfect electric conductors working under 2.45 GHz frequency and 1500 W power supply to predict the electric field and dissipated heat distribution. The methodology of prediction was implemented using ANSYS based on FEM. The present prediction results showed higher electric field (400 kV/m and high dissipated heat (3.7×1010 W/m3 can be obtained for a soot sample backed with metal rods inserted vertically with gaps not exceeding 1.5 mm between the rods tips. Also increasing the number of metal rods, from 8 to 14 increases the maximum value of electric field formed in the soot sample to 575 kV/m. The simulation results revealed the ability of achieving high electric field by using microwave heating with the assistance of metal objects.

  6. Role of plasma EBV DNA levels in predicting recurrence of nasopharyngeal carcinoma in a western population

    Directory of Open Access Journals (Sweden)

    Ferrari Daris

    2012-05-01

    Full Text Available Abstract Background Loco-regionally advanced nasopharyngeal carcinomas can be cured by the combination of chemotherapy and radiotherapy. In Eastern countries, plasma levels of viral Epstein-Barr deoxyribonucleic acid (DNA are accurate in predicting recurrence, but few data are available in Western populations. The aim of this prospective study was to evaluate the relationship between viral Epstein-Barr DNA copy numbers in plasma and the response rate, progression-free survival and overall survival in a cohort of Western patients with stage IIb-IVb nasopharyngeal cancer. Methods We evaluated plasma samples from 36 consecutive patients treated with induction chemotherapy followed by chemoradiation. EBV copy numbers were determined after DNA extraction using real-time quantitative polymerase chain reaction. Survival curves were estimated using the Kaplan–Meier method. Results Circulating Epstein-Barr virus DNA levels were measured before treatment, at the end of concomitant chemo- and radiotherapy, and during the follow-up period. Pre-treatment levels significantly correlated with the initial stage and probability of relapse. Their increase was 100% specific and 71.3% sensitive in detecting loco-regional or metastatic recurrence (an overall accuracy of 94.4%. Three-year progression-free and overall survival were respectively 78.2% and 97.1%. Conclusions The results of this study confirm that patients from a Western country affected by loco-regionally advanced nasopharyngeal carcinoma have high plasma Epstein-Barr virus DNA levels at diagnosis. The monitoring of plasma levels is sensitive and highly specific in detecting disease recurrence and metastases.

  7. Calibrating Photometric Redshifts of Luminous Red Galaxies

    CERN Document Server

    Padmanabhan, N; Schlegel, D J; Bridges, T J; Brinkmann, J; Cannon, R; Connolly, A J; Croom, S M; Csabai, I; Drinkwater, M; Eisenstein, D J; Hewett, P C; Loveday, J; Nichol, R C; Pimbblet, K A; De Propris, R; Schneider, D P; Scranton, R; Seljak, U; Shanks, T; Szapudi, I; Szalay, A S; Wake, D; Padmanabhan, Nikhil; Budavari, Tamas; Schlegel, David J.; Bridges, Terry; Brinkmann, Jonathan; Cannon, Russell; Connolly, Andrew J.; Croom, Scott M.; Csabai, Istvan; Drinkwater, Michael; Eisenstein, Daniel J.; Hewett, Paul C.; Loveday, Jon; Nichol, Robert C.; Pimbblet, Kevin A.; Propris, Roberto De; Schneider, Donald P.; Scranton, Ryan; Seljak, Uros; Shanks, Tom; Szapudi, Istvan; Szalay, Alexander S.; Wake, David

    2004-01-01

    We discuss the construction of a photometric redshift catalogue of Luminous Red Galaxies (LRGs) from the Sloan Digital Sky Survey (SDSS), emphasizing the principal steps necessary for constructing such a catalogue -- (i) photometrically selecting the sample, (ii) measuring photometric redshifts and their error distributions, (iii) and estimating the true redshift distribution. We compare two photometric redshift algorithms for these data and find that they give comparable results. Calibrating against the SDSS and SDSS-2dF spectroscopic surveys, we find that the photometric redshift accuracy is $\\sigma \\sim 0.03$ for redshifts less than 0.55 and worsens at higher redshift ($\\sim 0.06$). These errors are caused by photometric scatter, as well as systematic errors in the templates, filter curves, and photometric zeropoints. We also parametrize the photometric redshift error distribution with a sum of Gaussians, and use this model to deconvolve the errors from the measured photometric redshift distribution to est...

  8. The Mass-Concentration-Redshift Relation of Cold Dark Matter Halos

    CERN Document Server

    Ludlow, Aaron D; Angulo, Raul E; Boylan-Kolchin, Michael; Springel, Volker; Frenk, Carlos; White, Simon D M

    2013-01-01

    We use the Millennium Simulation series to investigate the mass and redshift dependence of the concentration of equilibrium cold dark matter (CDM) halos. We extend earlier work on the relation between halo mass profiles and assembly histories to show how the latter may be used to predict concentrations for halos of all masses and at any redshift. Our results clarify the link between concentration and the ``collapse redshift'' of a halo as well as why concentration depends on mass and redshift solely through the dimensionless ``peak height'' mass parameter, $\

  9. Plasma DNA methylation of Wnt antagonists predicts recurrence of esophageal squamous cell carcinoma

    Institute of Scientific and Technical Information of China (English)

    Ji-Bin Liu; Fu-Lin Qiang; Jing Dong; Jin Cai; Shu-Hui Zhou; Min-Xin Shi; Ke-Ping Chen; Zhi-Bin Hu

    2011-01-01

    AIM: To detect the effects of plasma DNA methylation of Wnt antagonists/inhibitors on recurrence of esophageal squamous cell carcinoma (ESCC).METHODS: We used methylation-specific polymerase chain reaction to detect hypermethylation of the promoter of four Wnt antagonists/inhibitors (SFRP-1, WIF-1, DKK-3 and RUNX3) using DNA from the plasma of ESCC patients (n = 81) and analyzed the association between promoter hypermethylation of Wnt pathway modulator genes and the two-year recurrence of ESCC.RESULTS: Hypermethylation of SFRP-1, DKK-3 and RUNX-3 was significantly associated with an increased risk of ESCC recurrence (P = 0.001, 0.003 and 0.001 for SFRP-1, DKK-3 and RUNX3, respectively). Patients carrying two to three methylated genes had a significantly elevated risk of recurrence compared with those not carrying methylated genes (odds ratio = 15.69, 95% confidential interval: 2.97-83). The area under the receiver operating characteristic curve (AUC) was 77.1 for ESCC recurrence prediction (sensitivity = 66.67 and specificity = 83.3). When combining methylated genes and the clinical stage, the AUC was 83.69, with a sensitivity of 76.19 and a specificity of 83.3.CONCLUSION: The status of promoter hypermethylation of Wnt antagonists/inhibitors in plasma may serve as a non-invasive prognostic biomarker for ESCC.

  10. Photometric Redshift Estimation Using Spectral Connectivity Analysis

    CERN Document Server

    Freeman, P E; Lee, A B; Richards, J W; Schafer, C M

    2009-01-01

    The development of fast and accurate methods of photometric redshift estimation is a vital step towards being able to fully utilize the data of next-generation surveys within precision cosmology. In this paper we apply a specific approach to spectral connectivity analysis (SCA; Lee & Wasserman 2009) called diffusion map. SCA is a class of non-linear techniques for transforming observed data (e.g., photometric colours for each galaxy, where the data lie on a complex subset of p-dimensional space) to a simpler, more natural coordinate system wherein we apply regression to make redshift predictions. As SCA relies upon eigen-decomposition, our training set size is limited to ~ 10,000 galaxies; we use the Nystrom extension to quickly estimate diffusion coordinates for objects not in the training set. We apply our method to 350,738 SDSS main sample galaxies, 29,816 SDSS luminous red galaxies, and 5,223 galaxies from DEEP2 with CFHTLS ugriz photometry. For all three datasets, we achieve prediction accuracies on ...

  11. Predictive Role of Intraoperative Plasma Fibrinogen for Postoperative Portal Venous Flow in Living Donor Liver Transplantation.

    Science.gov (United States)

    Chae, Min Suk; Park, Chul Soo; Oh, Su A; Hong, Sang Hyun

    2017-02-14

    BACKGROUND Previous studies have reported poor graft regeneration after living donor liver transplantation (LDLT) due to inappropriate portal venous flow (PVF). In this study, we investigated the perioperative factors affecting postoperative PVF after LDLT. MATERIAL AND METHODS The perioperative data of 366 LDLT patients were retrospectively reviewed. The average PVF on postoperative days 1, 3, and 5 was measured and dichotomized at a cut-off value for patient survival of 1,477 mL/min. Perioperative variables, including coagulation profiles, were compared between high and low postoperative PVF groups. The factors potentially significant (plow postoperative PVF were evaluated in a univariate analysis, followed by the development of a predictive model for a low postoperative PVF. RESULTS A low post-LDLT PVF was determined in 113 patients (30.9%). The univariate analysis identified systemic hypertension, LDLT duration, average mean blood pressure, and insulin administration as the significantly related factors. Other significant factors were a plasma fibrinogen, at the anhepatic phase and 1 h after graft reperfusion, as well as the platelet count at the anhepatic phase. After multivariate adjustment, plasma fibrinogen 1 h after graft reperfusion against a recipient background of systemic hypertension was independently associated with a low mean postoperative PVF. CONCLUSIONS A low mean PVF during the early post-LDLT period was independently related to the plasma fibrinogen level 1 h after graft reperfusion, and to a history of systemic hypertension. Thus, the practice of aggressive supplementation of plasma fibrinogen during the immediate post-reperfusion period merits serious consideration.

  12. Predicting Prostate Biopsy Results Using a Panel of Plasma and Urine Biomarkers Combined in a Scoring System

    DEFF Research Database (Denmark)

    Albitar, Maher; Ma, Wanlong; Lund, Lars;

    2016-01-01

    , and PTEN in plasma and urine. Patient age, serum prostate-specific antigen (sPSA) level, and biomarkers data were used to develop two independent algorithms, one for predicting the presence of PCa and the other for predicting high-grade PCa (Gleason score [GS] ≥7). RESULTS: Using training and validation...... a scoring system to predict prostate biopsy results and the presence of high grade PCa. METHODS: Urine and plasma specimens were collected from 319 patients recommended for prostate biopsies. We measured the gene expression levels of UAP1, PDLIM5, IMPDH2, HSPD1, PCA3, PSA, TMPRSS2, ERG, GAPDH, B2M, AR...

  13. Precision Cosmology with a New Probabilistic Photometric Redshifts Approach

    Science.gov (United States)

    Carrasco Kind, Matias; Brunner, R. J.

    2013-06-01

    A complete understanding of both dark energy and dark matter remains one of most important challenges in astrophysics today. Recent theoretical and numerical computations have made important progress in quantifying the role of these dark components on the formation and evolution of galaxies through cosmic time, but observational verification of these predictions and the development of new, more stringent constraints has not kept pace. It is in this context that, photometric redshifts have become more important with the growth of large imaging surveys, such as DES and LSST, that have been designed to address this issue. But their basic implementation has not changed significantly from their original development, as most techniques provide a single photometric redshift estimate and an associated error for the an extragalactic source. In this work, we present a unique and powerful solution that leverages the full information contained in the photometric data to address this cosmological challenge with a new approach that provides accurate photometric redshift probability density functions (PDF) for galaxies. This new approach, which scales efficiently to massive data, efficiently combines standard template fitting techniques with powerful machine learning methods. Included in this framework is our recently developed technique entitled Trees for PhotoZ (TPZ); a new, robust, parallel photometric redshift code that uses prediction trees and random forests to generate photo-z PDFs in a reliable and fast manner. In addition, our approach also provides ancillary information about the internal structure of the data, including the relative importance of variables used during the redshift estimation, an identification of areas in the training sample that provide poor predictions, and an accurate outlier rejection method. We will also present current results of this approach on a variety of datasets and discuss, by using specific examples, how the full photo-z PDF can be

  14. Obscured AGN at High Redshift

    Science.gov (United States)

    Stern, Daniel

    2008-01-01

    This viewgraph presentation reviews the obscured sources of Active Galactic Nuclei (AGN) in the universe at high redshift. The cosmic X-ray background, unified models of AGN and clues to galaxy formation/evolution is the motivation for this study.

  15. The Highest Redshift Relativistic Jets

    Energy Technology Data Exchange (ETDEWEB)

    Cheung, C.C.; Stawarz, L.; Siemiginowska, A.; Harris, D.E; Schwartz, D.A.; Wardle, J.F.C.; Gobeille, D.; Lee, N.P.

    2007-12-18

    We describe our efforts to understand large-scale (10's-100's kpc) relativistic jet systems through observations of the highest-redshift quasars. Results from a VLA survey search for radio jets in {approx} 30 z > 3.4 quasars are described along with new Chandra observations of 4 selected targets.

  16. Usefulness of plasma copeptin as a biomarker to predict the therapeutic effectiveness of metoprolol for postural tachycardia syndrome in children.

    Science.gov (United States)

    Zhao, Juan; Du, Shuxu; Yang, Jinyan; Lin, Jing; Tang, Chaoshu; Du, Junbao; Jin, Hongfang

    2014-08-15

    Metoprolol is clinically used to treat postural tachycardia syndrome (POTS) in children, but its effectiveness is unsatisfactory. Biomarkers to predict therapeutic efficacy are needed. We aimed to explore changes in the plasma copeptin level for assessing the therapeutic efficacy of metoprolol for POTS in children. We included 49 children with POTS and 25 healthy children as controls. Patients received metoprolol for 1.5 to 3 months. The plasma copeptin level was measured by sandwich immunoluminometric assay. The area under the receiver operating characteristic curve was used to explore the predictive value of the plasma copeptin level. The baseline plasma copeptin level was higher in children with POTS than controls (10.524 ± 2.016 vs 8.750 ± 1.419 pmol/L, p metoprolol (9.377 ± 1.411 vs 12.054 ± 1.662 pmol/L, p = 0.003). The area under the receiver operating characteristic curve was 0.889 (95% confidence interval 0.799 to 0.980). With a baseline plasma copeptin level of 10.225 pmol/L as a cutoff, the sensitivity was 90.5% and specificity 78.6% in predicting the efficacy of metoprolol in children with POTS. In conclusion, the baseline plasma copeptin level can be used as a biomarker to predict the therapeutic effectiveness of metoprolol in children with POTS.

  17. Stable isotope models of sugar intake using hair, red blood cells, and plasma, but not fasting plasma glucose, predict sugar intake in a Yup'ik study population.

    Science.gov (United States)

    Nash, Sarah H; Kristal, Alan R; Hopkins, Scarlett E; Boyer, Bert B; O'Brien, Diane M

    2014-01-01

    Objectively measured biomarkers will help to resolve the controversial role of sugar intake in the etiology of obesity and related chronic diseases. We recently validated a dual-isotope model based on RBC carbon (δ(13)C) and nitrogen (δ(15)N) isotope ratios that explained a large percentage of the variation in self-reported sugar intake in a Yup'ik study population. Stable isotope ratios can easily be measured from many tissues, including RBCs, plasma, and hair; however, it is not known how isotopic models of sugar intake compare among these tissues. Here, we compared self-reported sugar intake with models based on RBCs, plasma, and hair δ(13)C and δ(15)N in Yup'ik people. We also evaluated associations of sugar intake with fasting plasma glucose δ(13)C. Finally, we evaluated relations between δ(13)C and δ(15)N values in hair, plasma, RBCs, and fasting plasma glucose to allow comparison of isotope ratios across tissue types. Models using RBCs, plasma, or hair isotope ratios explained similar amounts of variance in total sugar, added sugar, and sugar-sweetened beverage intake (∼53%, 48%, and 34%, respectively); however, the association with δ(13)C was strongest for models based on RBCs and hair. There were no associations with fasting plasma glucose δ(13)C (R(2) = 0.03). The δ(13)C and δ(15)N values of RBCs, plasma, and hair showed strong, positive correlations; the slopes of these relations did not differ from 1. This study demonstrates that RBC, plasma, and hair isotope ratios predict sugar intake and provides data that will allow comparison of studies using different sample types.

  18. METAPHOR: Probability density estimation for machine learning based photometric redshifts

    Science.gov (United States)

    Amaro, V.; Cavuoti, S.; Brescia, M.; Vellucci, C.; Tortora, C.; Longo, G.

    2017-06-01

    We present METAPHOR (Machine-learning Estimation Tool for Accurate PHOtometric Redshifts), a method able to provide a reliable PDF for photometric galaxy redshifts estimated through empirical techniques. METAPHOR is a modular workflow, mainly based on the MLPQNA neural network as internal engine to derive photometric galaxy redshifts, but giving the possibility to easily replace MLPQNA with any other method to predict photo-z's and their PDF. We present here the results about a validation test of the workflow on the galaxies from SDSS-DR9, showing also the universality of the method by replacing MLPQNA with KNN and Random Forest models. The validation test include also a comparison with the PDF's derived from a traditional SED template fitting method (Le Phare).

  19. Multipole analysis of redshift-space distortions around cosmic voids

    Science.gov (United States)

    Hamaus, Nico; Cousinou, Marie-Claude; Pisani, Alice; Aubert, Marie; Escoffier, Stéphanie; Weller, Jochen

    2017-07-01

    We perform a comprehensive redshift-space distortion analysis based on cosmic voids in the large-scale distribution of galaxies observed with the Sloan Digital Sky Survey. To this end, we measure multipoles of the void-galaxy cross-correlation function and compare them with standard model predictions in cosmology. Merely considering linear-order theory allows us to accurately describe the data on the entire available range of scales and to probe void-centric distances down to about 2 h-1Mpc. Common systematics, such as the Fingers-of-God effect, scale-dependent galaxy bias, and nonlinear clustering do not seem to play a significant role in our analysis. We constrain the growth rate of structure via the redshift-space distortion parameter β at two median redshifts, β(bar z=0.32)=0.599+0.134-0.124 and β(bar z=0.54)=0.457+0.056-0.054, with a precision that is competitive with state-of-the-art galaxy-clustering results. While the high-redshift constraint perfectly agrees with model expectations, we observe a mild 2σ deviation at bar z=0.32, which increases to 3σ when the data is restricted to the lowest available redshift range of 0.15

  20. $\\gamma$-Ray Absorption at High Redshifts and the $\\gamma$-Ray Background

    CERN Document Server

    Stecker, F W

    1997-01-01

    We present results of a calculation of absorption of 10-500 GeV gamma-rays at high redshifts. This calculation requires the determination of the high- redshift evolution of the full spectral energy distribution of the intergalactic photon field. For this, we have primarily followed the recent analysis of Fall, Charlot and Pei. We give our results for the gamma-ray opacity as a function of redshift out to a redshift of 3. We then give predicted gamma-ray spectra for selected blazars and also extend our results on the background from unresolved blazars to an energy of 500 GeV. Absorption effects are predicted to significantly steepen the background spectrum above 20 GeV. Our absorption calculations can be used to place limits on the redshifts of gamma-ray bursts. Our background calculations can be used to determine the observability of multi-GeV lines from dark matter neutralino particles.

  1. Predictions for the energy loss of light ions in laser-generated plasmas at low and medium velocities.

    Science.gov (United States)

    Cayzac, W; Bagnoud, V; Basko, M M; Blažević, A; Frank, A; Gericke, D O; Hallo, L; Malka, G; Ortner, A; Tauschwitz, An; Vorberger, J; Roth, M

    2015-11-01

    The energy loss of light ions in dense plasmas is investigated with special focus on low to medium projectile energies, i.e., at velocities where the maximum of the stopping power occurs. In this region, exceptionally large theoretical uncertainties remain and no conclusive experimental data are available. We perform simulations of beam-plasma configurations well suited for an experimental test of ion energy loss in highly ionized, laser-generated carbon plasmas. The plasma parameters are extracted from two-dimensional hydrodynamic simulations, and a Monte Carlo calculation of the charge-state distribution of the projectile ion beam determines the dynamics of the ion charge state over the whole plasma profile. We show that the discrepancies in the energy loss predicted by different theoretical models are as high as 20-30%, making these theories well distinguishable in suitable experiments.

  2. Edgeworth streaming model for redshift space distortions

    CERN Document Server

    Uhlemann, Cora

    2015-01-01

    We derive the Edgeworth streaming model (ESM) for the redshift space correlation function starting from an arbitrary distribution function for biased tracers of dark matter by considering its two-point statistics and show that it reduces to the Gaussian streaming model (GSM) when neglecting non-Gaussianities. We test the accuracy of the GSM and ESM independent of perturbation theory using the Horizon Run 2 N-body halo catalog. While the monopole of the redshift space halo correlation function is well described by the GSM, higher multipoles improve upon including the leading order non-Gaussian correction in the ESM: the GSM quadrupole breaks down on scales below 30 Mpc/h whereas the ESM stays accurate to 2% within statistical errors down to 10 Mpc/h. To predict the scale dependent functions entering the streaming model we employ Convolution Lagrangian perturbation theory (CLPT) based on the dust model and local Lagrangian bias. Since dark matter halos carry an intrinsic length scale given by their Lagrangian r...

  3. Predicting Prostate Biopsy Results Using a Panel of Plasma and Urine Biomarkers Combined in a Scoring System

    DEFF Research Database (Denmark)

    Albitar, Maher; Ma, Wanlong; Lund, Lars;

    2016-01-01

    a scoring system to predict prostate biopsy results and the presence of high grade PCa. METHODS: Urine and plasma specimens were collected from 319 patients recommended for prostate biopsies. We measured the gene expression levels of UAP1, PDLIM5, IMPDH2, HSPD1, PCA3, PSA, TMPRSS2, ERG, GAPDH, B2M, AR......, and PTEN in plasma and urine. Patient age, serum prostate-specific antigen (sPSA) level, and biomarkers data were used to develop two independent algorithms, one for predicting the presence of PCa and the other for predicting high-grade PCa (Gleason score [GS] ≥7). RESULTS: Using training and validation...... data sets, a model for predicting the outcome of PCa biopsy was developed with an area under receiver operating characteristic curve (AUROC) of 0.87. The positive and negative predictive values (PPV and NPV) were 87% and 63%, respectively. We then developed a second algorithm to identify patients...

  4. Plasma Flowfields Around Low Earth Orbit Objects: Aerodynamics to Underpin Orbit Predictions

    Science.gov (United States)

    Capon, Christopher; Boyce, Russell; Brown, Melrose

    2016-07-01

    Interactions between orbiting bodies and the charged space environment are complex. The large variation in passive body parameters e.g. size, geometry and materials, makes the plasma-body interaction in Low Earth Orbit (LEO) a region rich in fundamental physical phenomena. The aerodynamic interaction of LEO orbiting bodies with the neutral environment constitutes the largest non-conservative force on the body. However in general, study of the LEO plasma-body interaction has not been concerned with external flow physics, but rather with the effects on surface charging. The impact of ionospheric flow physics on the forces on space debris (and active objects) is not well understood. The work presented here investigates the contribution that plasma-body interactions have on the flow structure and hence on the total atmospheric force vector experienced by a polar orbiting LEO body. This work applies a hybrid Particle-in-Cell (PIC) - Direct Simulation Monte Carlo (DSMC) code, pdFoam, to self-consistently model the electrostatic flowfield about a cylinder with a uniform, fixed surface potential. Flow conditions are representative of the mean conditions experienced by the Earth Observing Satellite (EOS) based on the International Reference Ionosphere model (IRI-86). The electron distribution function is represented by a non-linear Boltzmann electron fluid and ion gas-surface interactions are assumed to be that of a neutralising, conducting, thermally accommodating solid wall with diffuse reflections. The variation in flowfield and aerodynamic properties with surface potential at a fixed flow condition is investigated, and insight into the relative contributions of charged and neutral species to the flow physics experienced by a LEO orbiting body is provided. This in turn is intended to help improve the fidelity of physics-based orbit predictions for space debris and other near-Earth space objects.

  5. Plasma Efavirenz Exposure, Sex, and Age Predict Virological Response in HIV-Infected African Children.

    Science.gov (United States)

    Bienczak, Andrzej; Denti, Paolo; Cook, Adrian; Wiesner, Lubbe; Mulenga, Veronica; Kityo, Cissy; Kekitiinwa, Addy; Gibb, Diana M; Burger, David; Walker, A Sarah; McIlleron, Helen

    2016-10-01

    Owing to insufficient evidence in children, target plasma concentrations of efavirenz are based on studies in adults. Our analysis aimed to evaluate the pediatric therapeutic thresholds and characterize the determinants of virological suppression in African children. We analyzed data from 128 African children (aged 1.7-13.5 years) treated with efavirenz, lamivudine, and one among abacavir, stavudine, or zidovudine, and followed up to 36 months. Individual pharmacokinetic (PK) measures [plasma concentration 12 hours after dose (C12h), plasma concentration 24 hours after dose (C24h), and area under the curve (AUC0-24)] were estimated using population PK modeling. Cox multiple failure regression and multivariable fractional polynomials were used to investigate the risks of unsuppressed viral load associated with efavirenz exposure and other factors among 106 initially treatment-naive children, and likelihood profiling was used to identify the most predictive PK thresholds. The risk of viral load >100 copies per milliliter decreased by 42% for every 2-fold increase in efavirenz mid-dose concentration [95% confidence interval (CI): 23% to 57%; P Children older than 8 years had a more than 10-fold increased risk of virological nonsuppression (P = 0.005); among children younger than 8 years, boys had a 5.31 times higher risk than girls (P = 0.007). Central nervous system adverse events were infrequently reported. Our analysis suggests that the minimum target C24h and AUC0-24 could be lowered in children. Our findings should be confirmed in a prospective pediatric trial.

  6. Muscle fatigue experienced during maximal eccentric exercise is predictive of the plasma creatine kinase (CK) response.

    Science.gov (United States)

    Hody, S; Rogister, B; Leprince, P; Wang, F; Croisier, J-L

    2013-08-01

    Unaccustomed eccentric exercise may cause skeletal muscle damage with an increase in plasma creatine kinase (CK) activity. Although the wide variability among individuals in CK response to standardized lengthening contractions has been well described, the reasons underlying this phenomenon have not yet been understood. Therefore, this study investigated a possible correlation of the changes in muscle damage indirect markers after an eccentric exercise with the decline in muscle performance during the exercise. Twenty-seven healthy untrained male subjects performed three sets of 30 maximal isokinetic eccentric contractions of the knee extensors. The muscular work was recorded using an isokinetic dynamometer to assess muscle fatigue by means of various fatigue indices. Plasma CK activity, muscle soreness, and stiffness were measured before (pre) and one day after (post) exercise. The eccentric exercise bout induced significant changes of the three muscle damage indirect markers. Large inter-subject variability was observed for all criteria measured. More interestingly, the log (CK(post) /CK(pre)) and muscle stiffness appeared to be closely correlated with the relative work decrease (r = 0.84, r(2)  = 0.70 and r = 0.75, r(2)  = 0.56, respectively). This is the first study to propose that the muscle fatigue profile during maximal eccentric protocol could predict the magnitude of the symptoms associated with muscle damage in humans.

  7. A single untimed plasma drug concentration measurement during low-level HIV viremia predicts virologic failure.

    Science.gov (United States)

    Gonzalez-Serna, A; Swenson, L C; Watson, B; Zhang, W; Nohpal, A; Auyeung, K; Montaner, J S; Harrigan, P R

    2016-12-01

    Suboptimal untimed plasma drug levels (UDL) have been associated with lower rates of virologic suppression and the emergence of drug resistance. Our aim was to evaluate whether UDL among patients with low-level viremia (LLV) while receiving highly active antiretroviral therapy (HAART) can predict subsequent virologic failure (plasma viral load ≥1000 copies/mL) and emergence of resistance. The first documented LLV episode of 328 consenting patients was analysed in terms of drug levels, viral load and resistance, which were monitored while patients were on a consistent HAART regimen. UDL of protease inhibitors (PIs) and non-nucleoside reverse transcriptase inhibitors (NNRTIs), were categorized as 'therapeutic' or 'subtherapeutic' based on predefined target trough concentrations. Drug resistance genotype was assessed using the Stanford algorithm. Time to virologic failure was evaluated by Kaplan-Meier analysis and Cox proportional hazards regression. We found 78 of 328 patients (24%) with subtherapeutic drug levels at time of first detectable LLV, while 19% harboured drug-resistant virus. Both subtherapeutic UDL and drug resistance independently increased the risk of subsequent virologic failure (p resistance. Patients with subtherapeutic UDL accumulated further drug resistance faster during follow-up (p 0.03). Together, resistance and UDL variables can explain a higher proportion of virologic failure than either measure alone. Our results support further prospective evaluation of UDL in the management of low-level viremia. Crown Copyright © 2016. Published by Elsevier Ltd. All rights reserved.

  8. Modifying Gravity at Low Redshift

    CERN Document Server

    Brax, Philippe; Davis, Anne-Christine; Shaw, Douglas

    2010-01-01

    We consider the growth of cosmological perturbations in modified gravity models where a scalar field mediates a non-universal Yukawa force between different matter species. The growth of the density contrast is altered for scales below the Compton wave-length of the scalar field. As the universe expands, the Compton wave-length varies in time in such a way that scales which where outside the range of the scalar field force may feel it at a lower redshift. In this case, both the exponent $\\gamma$ measuring the growth of Cold Dark Matter perturbations and the shift function representing the ratio of the two Newtonian potentials $\\psi$ and $\\phi$ may differ from their values in General Relativity at low redshift.

  9. Searches for High Redshift Clusters

    CERN Document Server

    Dickinson, M

    1996-01-01

    High redshift galaxy clusters have traditionally been a fruitful place to study galaxy evolution. I review various search strategies for finding clusters at z > 1. Most efforts to date have concentrated on the environments of distant AGN. I illustrate these with data on the cluster around 3C 324 (z=1.2) and other, more distant systems, and discuss possibilities for future surveys with large telescopes.

  10. Plasma TF activity predicts cardiovascular mortality in patients with acute myocardial infarction

    Directory of Open Access Journals (Sweden)

    Groha Philip

    2009-07-01

    Full Text Available Abstract Objectives and Background Tissue factor (TF contributes to thrombosis following plaque disruption in acute coronary syndromes (ACS. Aim of the study was to investigate the impact of plasma TF activity on prognosis in patients with ACS. Methods and Results One-hundred seventy-four patients with unstable Angina pectoris (uAP and 112 patients with acute myocardial infarction (AMI were included with a mean follow up time of 3.26 years. On admission, plasma TF activity was assessed. Patients were categorized into 2 groups: a high-TF activity group with TF >24 pmol/L and low TF activity group with TF ≤ 24 pmol/L. Fifteen cardiovascular deaths occurred in the uAP group and 16 in the AMI group. In AMI TF activity was 24,9 ± 2,78 pmol/l (mean ± SEM in survivors and 40,9 ± 7,96 pmol/l in nonsurvivors (P = 0.024. In uAP no differences were observed (25.0 ± 8.04 pmol/L nonsurvivors vs. 25.7 ± 2.14 pmol/L survivors; P = 0.586. Kaplan-Meier estimates of survival at 3.26 years regarding TF activity in AMI were 81.3% and 92.2% with an hazard ratio of 3.02 (95% CI [1.05–8.79], P = 0.03. The Cox proportional hazards model adjusting for correlates of age and risk factors showed that plasma TF activity was an independent correlate of survival (hazard ratio 9.27, 95% CI [1.24–69.12], P = 0.03. In an additional group of patients with uAP and AMI, we identified circulating microparticles as the prevailing reservoir of plasma TF activity in acute coronary syndromes. Conclusion Systemic TF activity in AMI has an unfavorable prognostic value and as a marker for dysregulated coagulation may add to predict the atherothrombotic risk.

  11. Predicting Successful Pulmonary Vein Isolation In Patients With Atrial Fibrillation By Brain Natriuretic Peptide Plasma Levels

    Directory of Open Access Journals (Sweden)

    Dong-In Shin

    2009-09-01

    Full Text Available Background: Catheter ablation for atrial fibrillation is a clinically established treatment by now while success rate varies between 60% and 85%. Interventional treatment of atrial fibrillation is still a challenging technique associated with a long procedure time and risk of major complications in up to 6 % of treated patients. The aim of this study was to investigate the predictive value of plasma brain natriuretic peptide (BNP in patients undergoing pulmonary vein isolation concerning stable sinus rhythm after ablation.Methods: In 68 consecutive patients with atrial fibrillation (AF and normal left ventricular ejection fraction, BNP was measured at baseline before pulmonary vein isolation (PVI. All patients received a 7-days-holter monitoring 3 months after radiofrequency (RF ablation in order to detect recurrent AF episodes. Results: 48 patients with paroxysmal and 20 patients with persistent AF were enrolled. Baseline BNP was significantly higher in patients with persistent AF compared to patients with paroxysmal AF (145,5 pg/ml vs. 84,4 pg/ml; p<0,05. 3 months after PVI 38 patients (79,1% with paroxysmal AF had a stable sinus rhythm documented on 7-days-holter monitoring, where as in 10 patients (20,9% AF episodes were detected. Patients with a successful PVI showed significantly lower BNP plasma levels at baseline compared to patients with AF recurrrence (68,7 pg/ml vs. 144,1 pg/ml; p<0,05. In patients with persistent AF 55% (11 cases had no recurrence of AF at 3 months 7-days holter and in 9 patients (45% AF recurred. BNP plasma levels at baseline were lower in patients with stable sinusrhythm after 3 months compared to the group of recurrent AF (105,8 pg/ml vs. 193,3 pg/ml; p=0,11. Conclusion: Patients with AF and low preprocedural BNP plasma levels showed a better outcome after PVI. Thus BNP may be helpful in patient selection for a successful treatment of AF by PVI.

  12. Redshift and Blueshift are due to the Medium Composition

    Science.gov (United States)

    Smarandache, Florentin

    2017-01-01

    The redshift is the shift from shorter wavelengths towards longer wavelengths [or from higher wave frequency to lower wave frequency]. And, reciprocally, the blueshift is the shift from longer wavelengths towards shorter wavelengths [or from lower wave frequency towards higher wave frequency]. The General Theory of Relativity asserts that the redshift and blueshift are entirely due to the Doppler's Effect, which is caused by the motion of light source: if the source is moving away from the observer the frequency received is lower [redshift], but if the source is moving towards the observer the frequency received is higher [blueshift]. But Doppler's Effect itself is actually an appearance to a Subjective Observer, because the frequency is the same all over (if one considers the Absolute Observer). We believe that the redshift and blueshift are not entirely due to the Doppler's Effect, but also due (as in the light bending) to the medium composition (medium that could be formed by waves, particles, plasma, dust, gaseous, fluids, solids, etc.), to the medium density, to the medium heterogeneity, to the medium structure, and to the electromagnetic and gravitational fields contained in that medium that may interfere with the light that passes through.

  13. Old Galaxies at High Redshift

    CERN Document Server

    Dunlop, J

    1997-01-01

    The most passive galaxies at high redshift are unlikely to be identified by either narrow-band emission-line searches, or by Lyman limit searches (both techniques which have been highlighted at this meeting) simply because such selection methods rely on the presence of a strong ultraviolet component. Selection on the basis of extreme radio power has also proved to yield optically active objects with the majority of high-redshift objects studied to date displaying complex elongated optical/UV morphologies, relatively blue optical-ultraviolet continuum colours, and strong emission lines. These features, coupled with the failure to detect any spectral signatures of old stars at $z > 1$, has led to the suggestion that these galaxies are being observed close to or even during a general epoch of formation. However, we have recently demonstrated that radio selection at significantly fainter (mJy) flux densities can be used to identify apparently passively evolving elliptical galaxies at high redshift. Deep Keck spec...

  14. El Universo a alto redshift

    Science.gov (United States)

    Alonso, M. V.

    The Universe we see today is the result of structures and galaxies that have been evolving since earlier times. Looking the evolution of the galaxy population at z ˜ 1 has emphasized the important role played by high redshift data. This is the case of the morphology - density relationship, where the morphological type of galaxies in distant clusters has given us a clear vision of evolutionary processes, partly led by environmental effects. I review part of the data available at high redshifts that are fundamental today to check the validity of galaxy formation models in reproducing local and basic galaxy properties. Briefly, I will comment about high redshift studies, a still little explored portion of the Universe, and the current strategies that allow us the study. In this sense, the epoch of reionization is essential for understanding the formation of structures because it is the phase where the first protogalaxies were formed, creating stars and enriching the intergalactic medium. Because of the great distances involved in these studies, gamma-ray bursts, quasars and Lyman-α galaxies are the best tools to study these earlier times. FULL TEXT IN SPANISH

  15. Dusty Quasars at High Redshifts

    CERN Document Server

    Weedman, Daniel

    2016-01-01

    A population of quasars at z ~ 2 is determined based on dust luminosities vLv(7.8 um) that includes unobscured, partially obscured, and obscured quasars. Quasars are classified by the ratio vLv(0.25 um)/vLv(7.8 um) = UV/IR, assumed to measure obscuration of UV luminosity by the dust which produces IR luminosity. Quasar counts at rest frame 7.8 um are determined for quasars in the Bootes field of the NOAO Deep Wide Field Survey using 24 um sources with optical redshifts from the AGN and Galaxy Evolution Survey (AGES) or infrared redshifts from the Spitzer Infrared Spectrograph. Spectral energy distributions are extended to far infrared wavelengths using observations from the Herschel Space Observatory Spectral and Photometric Imaging Receiver (SPIRE), and new SPIRE photometry is presented for 77 high redshift quasars from the Sloan Digital Sky Survey. It is found that unobscured and obscured quasars have similar space densities at rest frame 7.8 um, but the ratio Lv(100 um)/Lv(7.8 um) is about three times high...

  16. Two panels of plasma microRNAs as non-invasive biomarkers for prediction of recurrence in resectable NSCLC.

    Directory of Open Access Journals (Sweden)

    Céline Sanfiorenzo

    Full Text Available The diagnosis of non-small cell lung carcinoma (NSCLC at an early stage, as well as better prediction of outcome remains clinically challenging due to the lack of specific and robust non-invasive markers. The discovery of microRNAs (miRNAs, particularly those found in the bloodstream, has opened up new perspectives for tumor diagnosis and prognosis. The aim of our study was to determine whether expression profiles of specific miRNAs in plasma could accurately discriminate between NSCLC patients and controls, and whether they are able to predict the prognosis of resectable NSCLC patients. We therefore evaluated a series of seventeen NSCLC-related miRNAs by quantitative real-time (qRT-PCR in plasma from 52 patients with I-IIIA stages NSCLC, 10 patients with chronic obstructive pulmonary disease (COPD and 20-age, sex and smoking status-matched healthy individuals. We identified an eleven-plasma miRNA panel that could distinguish NSCLC patients from healthy subjects (AUC = 0.879. A six-plasma miRNA panel was able to discriminate between NSCLC patients and COPD patients (AUC = 0.944. Furthermore, we identified a three-miRNA plasma signature (high miR-155-5p, high miR-223-3p, and low miR-126-3p that significantly associated with a higher risk for progression in adenocarcinoma patients. In addition, a three-miRNA plasma panel (high miR-20a-5p, low miR-152-3p, and low miR-199a-5p significantly predicted survival of squamous cell carcinoma patients. In conclusion, we identified two plasma miRNA expression profiles that may be useful for predicting the outcome of patients with resectable NSCLC.

  17. Slipher's redshifts as support for de Sitter's model and the discovery of the dynamic universe

    CERN Document Server

    Nussbaumer, Harry

    2013-01-01

    Of the first two relativistiv world models, only the one by de Sitter predicted redshifted spectra from far away astronomical objects. Slipher's redshifts therefore seemed to arbitrate against Einstein's model which made no such predictions. Both models were trying to describe a static universe. However, Lemaitre found that de Sitter's construct resulted in a spatially inhomogeneous universe. He then opted for a model that correspondes to Einstein's closed, curved universe but allowed the radius of curvature to change with time. Slipher's redshifts suggested to him that the universe is dynamic and expanding. We also discuss the respective merits of Friedman and Lemaitre in revealing the dynamic nature of the universe.

  18. Predictions on heat transport and plasma rotation from global gyrokinetic simulations

    Science.gov (United States)

    Sarazin, Y.; Grandgirard, V.; Abiteboul, J.; Allfrey, S.; Garbet, X.; Ghendrih, Ph.; Latu, G.; Strugarek, A.; Dif-Pradalier, G.; Diamond, P. H.; Ku, S.; Chang, C. S.; McMillan, B. F.; Tran, T. M.; Villard, L.; Jolliet, S.; Bottino, A.; Angelino, P.

    2011-10-01

    Flux-driven global gyrokinetic codes are now mature enough to make predictions in terms of turbulence and transport in tokamak plasmas. Some of the recent breakthroughs of three such codes, namely GYSELA, ORB5 and XGC1, are reported and compared wherever appropriate. In all three codes, turbulent transport appears to be mediated by avalanche-like events, for a broad range of ρ* = ρi/a values, ratio of the gyro-radius over the minor radius. Still, the radial correlation length scales with ρi, leading to the gyro-Bohm scaling of the effective transport coefficient below ρ* ≈ 1/300. The possible explanation could be due to the fact that avalanches remain meso-scale due to the interaction with zonal flows, whose characteristic radial wavelength appears to be almost independent of the system size. As a result of the radial corrugation of the turbulence driven zonal and mean flows, the shear of the radial electric field can be significantly underestimated if poloidal rotation is assumed to be governed by the neoclassical theory, especially at low collisionality. Indeed, the turbulence contribution to the poloidal rotation increases when collisionality decreases. Finally, the numerical verification of toroidal momentum balance shows that both neoclassical and turbulent contributions to the Reynolds' stress tensor play the dominant role. The phase space analysis further reveals that barely passing supra-thermal particles mostly contribute to the toroidal flow generation, consistently with quasi-linear predictions.

  19. "Observing and Analyzing" Images From a Simulated High Redshift Universe

    CERN Document Server

    Morgan, Robert J; Scannapieco, Evan; Thacker, Robert J

    2015-01-01

    We investigate the high-redshift evolution of the restframe UV-luminosity function (LF) of galaxies via hydrodynamical cosmological simulations, coupled with an emulated observational astronomy pipeline that provides a direct comparison with observations. We do this by creating mock images and synthetic galaxy catalogs of approximately 100 square arcminute fields from the numerical model at redshifts ~ 4.5 to 10.4. We include the effects of dust extinction and the point spread function (PSF) for the Hubble WFC3 camera for comparison with space observations. We also include the expected zodiacal background to predict its effect on space observations, including future missions such as the James Webb Space Telescope (JWST). When our model catalogs are fitted to Schechter function parameters, we predict that the faint-end slope alpha of the LF evolves as alpha = -1.16 - 0.12 z over the redshift range z ~ 4.5 to 7.7, in excellent agreement with observations from e.g., Hathi et al. (2010). However, for redshifts z ...

  20. Transition redshift in $f(T)$ cosmology and observational constraints

    CERN Document Server

    Capozziello, Salvatore; Saridakis, Emmanuel N

    2015-01-01

    We extract constraints on the transition redshift $z_{tr}$, determining the onset of cosmic acceleration, predicted by an effective cosmographic construction, in the framework of $f(T)$ gravity. In particular, employing cosmography we obtain bounds on the viable $f(T)$ forms and their derivatives. Since this procedure is model independent, as long as the scalar curvature is fixed, we are able to determine intervals for $z_{tr}$. In this way we guarantee that the Solar-System constraints are preserved and moreover we extract bounds on the transition time and the free parameters of the scenario. We find that the transition redshifts predicted by $f(T)$ cosmology, although compatible with the standard $\\Lambda$CDM predictions, are slightly smaller. Finally, in order to obtain observational constraints on $f(T)$ cosmology, we perform a Monte Carlo fitting using supernova data, involving the most recent union 2.1 data set.

  1. Transition redshift in f (T ) cosmology and observational constraints

    Science.gov (United States)

    Capozziello, Salvatore; Luongo, Orlando; Saridakis, Emmanuel N.

    2015-06-01

    We extract constraints on the transition redshift ztr , determining the onset of cosmic acceleration, predicted by an effective cosmographic construction, in the framework of f (T ) gravity. In particular, employing cosmography we obtain bounds on the viable f (T ) forms and their derivatives. Since this procedure is model independent, as long as the scalar curvature is fixed, we are able to determine intervals for ztr . In this way we guarantee that the Solar-System constraints are preserved and, moreover, we extract bounds on the transition time and the free parameters of the scenario. We find that the transition redshifts predicted by f (T ) cosmology, although compatible with the standard Λ CDM predictions, are slightly smaller. Finally, in order to obtain observational constraints on f (T ) cosmology, we perform a Monte Carlo fitting using supernova data, involving the most recent Union 2.1 data set.

  2. Plasma citrulline levels predict intestinal toxicity in patients treated with pelvic radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Onal, Cem; Kotek, Ayse; Arslan, Gungor; Topkan, Erkan (Dept. of Radiation Oncology, Baskent Univ. Faculty of Medicine, Adana (Turkey)), E-mail: hcemonal@hotmail.com; Unal, Birsel (Dept. of Biochemistry, Baskent Univ. Faculty of Medicine, Ankara (Turkey)); Yavuz, Aydin; Yavuz, Melek (Dept. of Radiation Oncology, Akdeniz Univ. Faculty of Medicine, Antalya (Turkey))

    2011-11-15

    Background. Radiotherapy (RT) for abdominal and pelvic malignancies often causes severe small bowel toxicity. Citrulline concentrations are known to decrease with intestinal failure. We thus evaluated the feasibility of plasma citrulline levels in predicting radiation-induced intestinal toxicity. Material and methods. Fifty-three patients (36 prostate cancer, 17 endometrial cancer) who received 45 Gy pelvic RT using conventional fractionation were prospectively evaluated. Patients with prostate cancer received an additional 25-30.6 Gy conformal boost. Plasma citrulline levels were assessed on day 0, mid- (week 3) and post-RT (week 8), and four months post-RT. Dose-volume histogram, citrulline concentration changes, and weekly intestinal toxicity scores were analyzed. Results. Mean age was 63 years (range: 43-81 years) and mean baseline citrulline concentration was 38.0 +- 10.1 mumol/l. Citrulline concentrations were significantly reduced at week 3 (27.4 +- 5.9 mumol/l; p < 0.0001), treatment end (29.9 +- 8.8 mumol/l; p < 0.0001), and four months post-treatment (34.3 +- 12.1; p 0.01). The following factor pairs were significantly positively correlated: Citrulline concentration/mean bowel dose during, end of treatment, and four months post-RT; dose-volume parameters/citrulline change groups; cumulative mean radiation dose/intestinal toxicity at end and four months post-RT; citrulline changes/intestinal toxicity during and end of RT. Citrulline concentration changes significantly differed during treatment according to RTOG intestinal toxicity grades (p < 0.0001). Although the citrulline changes differed significantly within RTOG intestinal toxicity grades (p = 0.003), the difference between Grade 0 and Grade 1 did not differ significantly at the end of the treatment. At four months after RT, no significant differences were apparent. Conclusion. Citrulline-based assessment scores are objective and should be considered in measuring radiation-induced intestinal toxicity

  3. Baryon Acoustic Oscillations in 2D: Modeling Redshift-space Power Spectrum from Perturbation Theory

    CERN Document Server

    Taruya, Atsushi; Saito, Shun

    2010-01-01

    We present an improved prescription for matter power spectrum in redshift space taking a proper account of both the non-linear gravitational clustering and redshift distortion, which are of particular importance for accurately modeling baryon acoustic oscillations (BAOs). Contrary to the models of redshift distortion phenomenologically introduced but frequently used in the literature, the new model includes the corrections arising from the non-linear coupling between the density and velocity fields associated with two competitive effects of redshift distortion, i.e., Kaiser and Finger-of-God effects. Based on the improved treatment of perturbation theory for gravitational clustering, we compare our model predictions with monopole and quadrupole power spectra of N-body simulations, and an excellent agreement is achieved over the scales of BAOs. Potential impacts on constraining dark energy and modified gravity from the redshift-space power spectrum are also investigated based on the Fisher-matrix formalism. We...

  4. GPz: Non-stationary sparse Gaussian processes for heteroscedastic uncertainty estimation in photometric redshift

    CERN Document Server

    Almosallam, Ibrahim A; Roberts, Stephen J

    2016-01-01

    The next generation of cosmology experiments will be required to use photometric redshifts rather than spectroscopic redshifts. Obtaining accurate and well-characterized photometric redshift distributions is therefore critical for Euclid, the Large Synoptic Survey Telescope and the Square Kilometre Array. However, determining accurate variance predictions alongside single point estimates of photometric redshifts is crucial, as they can be used to optimize the sample of galaxies for the specific experiment (e.g. weak lensing, baryon acoustic oscillations, supernovae), trading off between completeness and reliability in the galaxy sample. The various sources of uncertainty (and noise) in measurements of the photometry and redshifts put a lower bound on the accuracy that any model can hope to achieve. The intrinsic uncertainty associated with estimates is often non-uniform and input-dependent. However, existing approaches are susceptible to outliers and do not take into account variance induced by non-uniform da...

  5. The plasma level of soluble urokinase receptor is elevated in patients with Streptococcus pneumoniae bacteraemia and predicts mortality

    DEFF Research Database (Denmark)

    Wittenhagen, p; Kronborg, Gitte; Nielsen, H

    2004-01-01

    This multicentre prospective study was conducted to investigate whether the level of the soluble form of urokinase-type plasminogen activator receptor (suPAR) is elevated during pneumococcal bacteraemia and is of predictive value in the early stage of the disease. Plasma levels of suPAR were incr...

  6. The plasma leptin/adiponectin ratio predicts first cardiovascular event in men : A prospective nested case-control study

    NARCIS (Netherlands)

    Kappelle, Paul J.W.H.; Dullaart, Robin P. F.; van Beek, Andre P.; Hillege, Hans L.; Wolffenbuttel, Bruce H. R.

    2012-01-01

    Objective: The plasma leptin/adiponectin (L/A) ratio has been proposed as a preferential marker of atherosclerosis susceptibility compared to leptin and adiponectin alone. We determined the extent to which the L/A ratio predicts incident cardiovascular disease (CVD) taking account of clinical risk f

  7. Urine and plasma metabolites predict the development of diabetic nephropathy in individuals with Type 2 diabetes mellitus

    NARCIS (Netherlands)

    Pena, M. J.; Lambers Heerspink, H. J.; Hellemons, M. E.; Friedrich, T.; Dallmann, G.; Lajer, M.; Bakker, S. J. L.; Gansevoort, R. T.; Rossing, P.; de Zeeuw, D.; Roscioni, S. S.

    Aims Early detection of individuals with Type 2 diabetes mellitus or hypertension at risk for micro- or macroalbuminuria may facilitate prevention and treatment of renal disease. We aimed to discover plasma and urine metabolites that predict the development of micro-or macroalbuminuria. Methods

  8. Use of plasma orosomucoid in newborn piglets to predict preweaning growth performance and its mechanism of action

    Science.gov (United States)

    Orosomucoid (ORM) is the most prevalent serum protein in the newborn pig. The present study was designed to determine if plasma ORM at birth can be used to predict the relative performance of piglets within a litter between birth and weaning using a highly sensitive ELISA specific for pig ORM. Sec...

  9. The Predictive Value of Plasma Fibronectin Concentration on Fetal Growth Retardation at Earlier Stage of the Third Trimester

    Institute of Scientific and Technical Information of China (English)

    WANG; Zehua; XIONG; Guirong; ZHU; Ying

    2001-01-01

    In order to evaluate the predictive value of maternal plasma fibronectin (FN) concentration at 24-34 weeks on fetal intrauterine growth retardation (IUGR), a prospective double-blinded study was performed. The maternal plasma FN concentrations were measured by using a rate nephelometric procedure in the 130 initial normal nulliparous pregnant woman at 24-34 gestational weeks.The outcome of pregnancies and birth weight of their infants were followed up. IUGR was defined as that the birth weight was less than the 10th percentile for gestational age. The receiver operating characteristic curves and predictive values of FN predicting on outcome of pregnancy with IUGR were analyzed. The results showed that: (1) In a cohort of 130 initially normal nulliparous pregnant women, IUGR occurred in 14 cases during the follow-up; (2) The plasma FN levels in the women with IUGR (467.58± 104.43 mg/L) were significantly higher than in the normal control group (299. 44±105.55 mg/L, P<0. 01). However, there was no significant difference in the mean maternal age,gravidity, sampling gestational ages, delivering gestational ages between the two groups (P>0. 05);(3) The areas under ROC curve for predicting the outcome of pregnancy in IUGR was 0. 893; (4)At the cut point of 475 mg/L FN level, the sensitivity, specificity, positive predictive value, negative predictive value and Kappa index for predicting the outcomes of pregnancy in IUGR were 57. 14 %,95. 69 %, 61.54 %, 94.87 %, 0. 5455 respectively. It was concluded that the maternal plasma FN might be used as an earlier predictor for screening of IUGR.

  10. High Redshift Gamma Ray Bursts

    Science.gov (United States)

    Gehrels, Neil

    2012-01-01

    The Swift Observatory has been detecting 100 gamma-ray bursts per year for 7 years and has greatly stimulated the field with new findings. Observations are made of the X-ray and optical afterglow from 1 minute after the burst, continuing for days. GRBs are providing a new tool to study the high redshift universe. Swift has detected several events at z>5 and one at z=9.4 giving information on metallicity, star formation rate and reionization. The talk will present the latest results.

  11. The Southern Sky Redshift Survey

    Science.gov (United States)

    da Costa, L. Nicolaci; Willmer, C. N. A.; Pellegrini, P. S.; Chaves, O. L.; Rité, C.; Maia, M. A. G.; Geller, M. J.; Latham, D. W.; Kurtz, M. J.; Huchra, J. P.; Ramella, M.; Fairall, A. P.; Smith, C.; Lípari, S.

    1998-07-01

    We report redshifts, magnitudes, and morphological classifications for 5369 galaxies with m_B Complejo Astronomico El Leoncito, operated under agreement between the Consejo Nacional de Investigaciones Científicas de la República Argentina and the National Universities of La Plata, Córdoba, and San Juan; the European Southern Observatory, La Silla, Chile, partially under the bilateral ESO-Observatório Nacional agreement; Fred Lawrence Whipple Observatory; Laboratório Nacional de Astrofísica, Brazil; and the South African Astronomical Observatory.

  12. High redshift quasars monitoring campaign

    Science.gov (United States)

    Botti, Ismael; Lira, Paulina; Martinez, Jorge; Netzer, Hagai; Kaspi, Shai

    2014-07-01

    We present an update of the monitoring campaign we have undertaken to probe the most massive black holes in powerful quasars at high redshift through the reverberation mapping technique. Once this campaign has finished, we will be able to directly measure broad line region (BLR) sizes of quasars at z ~ 2-3, improving dramatically the BLR size-luminosity relation, and therefore, black hole mass estimates based on this relationship. So far, we have identified a dozen highly variable sources suitable for future cross-correlation analysis and reverberation measurements.

  13. Redshift Properties of MASIV Sources

    Science.gov (United States)

    2010-06-01

    prerequisite. For optical identification we used mainly the Sloan Digital Sky Survey ( SDSS DR 5 Adelman-McCarthy et aJ. 2007) and GSC 2.3 (Lasker et...aJ. 2008). 165 sources werc identified from the SDSS DR5, which is complcte down to r=22.5 (Aef! rv6230A) with astrometric accuracy about (1.𔃻...than the SDSS . The new redshift were obtained using the 2.56 m Nordic Optical Telescope ·(NOT) which is locatcd at La Palma and the 5 m Palomar Hale

  14. Cosmological Parameters from Redshift-Space Correlations

    CERN Document Server

    Matsubara, T; Matsubara, Takahiko; Szalay, Alexander S.

    2002-01-01

    We estimate how clustering in large-scale redshift surveys can constrain various cosmological parameters. Depth and sky coverage of modern redshift surveys are greater than ever, opening new possibilities for statistical analysis. We have constructed a novel maximum likelihood technique applicable to deep redshift surveys of wide sky coverage by taking into account the effects of both curvature and linear velocity distortions. The Fisher information matrix is evaluated numerically to show the bounds derived from a given redshift sample. We find that intermediate-redshift galaxies, such as the Luminous Red Galaxies (LRGs) in the Sloan Digital Sky Survey, can constrain cosmological parameters, including the cosmological constant, unexpectedly well. The importance of the dense as well as deep sampling in designing redshift surveys is emphasized.

  15. Redshift uncertainties and baryonic acoustic oscillations

    CERN Document Server

    Chaves-Montero, Jonás; Hernández-Monteagudo, Carlos

    2016-01-01

    In the upcoming era of high-precision galaxy surveys, it becomes necessary to understand the impact of uncertain redshift estimators on cosmological observables. In this paper we present a detailed exploration of the galaxy clustering and baryonic acoustic oscillation (BAO) signal under the presence of redshift errors. We provide analytic expressions for how the monopole and the quadrupole of the redshift-space power spectrum (together with their covariances) are affected. Additionally, we discuss the modifications in the shape, signal to noise, and cosmological constraining power of the BAO signature. We show how and why the BAO contrast is $\\mathit{enhanced}$ with small redshift uncertainties, and explore in detail how the cosmological information is modulated by the interplay of redshift-space distortions, redshift errors, and the number density of the sample. We validate our results by comparing them with measurements from a ensemble of $N$-body simulations with $8100h^{-3}\\text{Gpc}^3$ aggregated volume....

  16. Measuring Galaxy Environments with Deep Redshift Surveys

    CERN Document Server

    Cooper, M C; Madgwick, D S; Gerke, B F; Yan, R; Davis, M; Cooper, Michael C.; Newman, Jeffrey A.; Madgwick, Darren S.; Gerke, Brian F.; Yan, Renbin; Davis, Marc

    2005-01-01

    We study the applicability of several galaxy environment measures (n^th-nearest-neighbor distance, counts in an aperture, and Voronoi volume) within deep redshift surveys. Mock galaxy catalogs are employed to mimic representative photometric and spectroscopic surveys at high redshift (z ~ 1). We investigate the effects of survey edges, redshift precision, redshift-space distortions, and target selection upon each environment measure. We find that even optimistic photometric redshift errors (\\sigma_z = 0.02) smear out the line-of-sight galaxy distribution irretrievably on small scales; this significantly limits the application of photometric redshift surveys to environment studies. Edges and holes in a survey field dramatically affect the estimation of environment, with the impact of edge effects depending upon the adopted environment measure. These edge effects considerably limit the usefulness of smaller survey fields (e.g. the GOODS fields) for studies of galaxy environment. In even the poorest groups and c...

  17. Weight loss predictability by plasma metabolic signatures in adults with obesity and morbid obesity of the DiOGenes study

    DEFF Research Database (Denmark)

    Stroeve, Johanna H M; Saccenti, Edoardo; Bouwman, Jildau

    2016-01-01

    kcal) for 8 weeks. Men (N = 236) and women (N = 431) as well as groups with overweight/obesity and morbid obesity were studied separately. The relation between the metabolic status before weight loss and weight loss was assessed by stepwise regression on multiple data sets, including anthropometric...... parameters, NMR-based plasma metabolites, and LC-MS-based plasma lipid species. RESULTS: Maximally, 57% of the variation in weight loss success can be predicted by baseline parameters. The most powerful predictive models were obtained in subjects with morbid obesity. In these models, the metabolites most......OBJECTIVE: Aim is to predict successful weight loss by metabolic signatures at baseline and to identify which differences in metabolic status may underlie variations in weight loss success. METHODS: In DiOGenes, a randomized, controlled trial, weight loss was induced using a low-calorie diet (800...

  18. The development of a quality prediction system for aluminum laser welding to measure plasma intensity using photodiodes

    Energy Technology Data Exchange (ETDEWEB)

    Yu, Ji Young [Technical Research Center, Hyundai Steel Company, Dangjin (Korea, Republic of); Sohn, Yong Ho [Dept. of Materials Science and Engineering, University of Central Florida, Orlando (United States); Park, Young Whan; Kwak, Jae Seob [Dept. of Mechanical Engineering, Pukyong National University, Busan (Korea, Republic of)

    2016-10-15

    Lightweight metals have been used to manufacture the body panels of cars to reduce the weight of car bodies. Typically, aluminum sheets are welded together, with a focus on weld quality assurance. A weld quality prediction system for the laser welding of aluminum was developed in this research to maximize welding production. The behavior of the plasma was also analyzed, dependent on various welding conditions. The light intensity of the plasma was altered with heat input and wire feed rate conditions, and the strength of the weld and sensor signals correlated closely for this heat input condition. Using these characteristics, a new algorithm and program were developed to evaluate the weld quality. The design involves a combinatory algorithm using a neural network model for the prediction of tensile strength from measured signals and a fuzzy multi-feature pattern recognition algorithm for the weld quality classification to improve predictability of the system.

  19. The New Physics of Cosmic Redshift

    CERN Document Server

    Hebel, Wolfgang

    2011-01-01

    Light rays received on earth from distant stars show redshift, being attributed conventionally to the well-known Doppler-effect of wave dynamics. The present study concludes that cosmic redshift rather is an effect of the quantum mechanical propagation of photons as explained by Nobel Laureate Richard FEYNMAN in his book on QED {2}. This alternative physics of cosmic redshift is fundamentally different from the conventional velocity argument and can therefore do without the controversial big bang idea.

  20. Cloning Dropouts: Implications for Galaxy Evolution at High Redshift

    CERN Document Server

    Bouwens, R J; Illingworth, G D; Bouwens, Rychard J.; Broadhurst, Tom; Illingworth, Garth

    2003-01-01

    The evolution of high redshift galaxies in the two Hubble Deep Fields, HDF-N and HDF-S, is investigated using a cloning technique that replicates z~ 2-3 U dropouts to higher redshifts, allowing a comparison with the observed B and V dropouts at higher redshifts (z ~ 4-5). We treat each galaxy selected for replication as a set of pixels that are k-corrected to higher redshift, accounting for resampling, shot-noise, surface-brightness dimming, and the cosmological model. We find evidence for size evolution (a 1.7x increase) from z ~ 5 to z ~ 2.7 for flat geometries (Omega_M+Omega_LAMBDA=1.0). Simple scaling laws for this cosmology predict that size evolution goes as (1+z)^{-1}, consistent with our result. The UV luminosity density shows a similar increase (1.85x) from z ~ 5 to z ~ 2.7, with minimal evolution in the distribution of intrinsic colors for the dropout population. In general, these results indicate less evolution than was previously reported, and therefore a higher luminosity density at z ~ 4-5 (~ 50...

  1. Cosmology with photometric redshift surveys

    CERN Document Server

    Blake, C; Blake, Chris; Bridle, Sarah

    2004-01-01

    We explore the utility of future photometric redshift imaging surveys for delineating the large-scale structure of the Universe, and assess the resulting constraints on the cosmological model. We perform two complementary types of analysis: (1) We quantify the statistical confidence and accuracy with which such surveys will be able to detect and measure characteristic features in the clustering power spectrum such as the acoustic oscillations and the turnover, in a model-independent fashion. For example, we show that a 10000 sq deg imaging survey with depth r = 22.5 and photometric redshift accuracy dz/(1+z) = 0.03 will detect the acoustic oscillations with 99.9% confidence, measuring the associated cosmological scale with 2% precision. Such a survey will also detect the turnover with 95% confidence, determining the corresponding scale with 20% accuracy. (2) By assuming a Lambda-CDM cosmology we calculate the confidence with which a non-zero baryon fraction can be deduced from such future surveys. After margi...

  2. Circulating plasma MiR-141 is a novel biomarker for metastatic colon cancer and predicts poor prognosis.

    Directory of Open Access Journals (Sweden)

    Hanyin Cheng

    Full Text Available BACKGROUND: Colorectal cancer (CRC remains one of the major cancer types and cancer related death worldwide. Sensitive, non-invasive biomarkers that can facilitate disease detection, staging and prediction of therapeutic outcome are highly desirable to improve survival rate and help to determine optimized treatment for CRC. The small non-coding RNAs, microRNAs (miRNAs, have recently been identified as critical regulators for various diseases including cancer and may represent a novel class of cancer biomarkers. The purpose of this study was to identify and validate circulating microRNAs in human plasma for use as such biomarkers in colon cancer. METHODOLOGY/PRINCIPAL FINDINGS: By using quantitative reverse transcription-polymerase chain reaction, we found that circulating miR-141 was significantly associated with stage IV colon cancer in a cohort of 102 plasma samples. Receiver operating characteristic (ROC analysis was used to evaluate the sensitivity and specificity of candidate plasma microRNA markers. We observed that combination of miR-141 and carcinoembryonic antigen (CEA, a widely used marker for CRC, further improved the accuracy of detection. These findings were validated in an independent cohort of 156 plasma samples collected at Tianjin, China. Furthermore, our analysis showed that high levels of plasma miR-141 predicted poor survival in both cohorts and that miR-141 was an independent prognostic factor for advanced colon cancer. CONCLUSIONS/SIGNIFICANCE: We propose that plasma miR-141 may represent a novel biomarker that complements CEA in detecting colon cancer with distant metastasis and that high levels of miR-141 in plasma were associated with poor prognosis.

  3. Circulating Plasma MiR-141 Is a Novel Biomarker for Metastatic Colon Cancer and Predicts Poor Prognosis

    Science.gov (United States)

    Cogdell, David E.; Zheng, Hong; Schetter, Aaron J.; Nykter, Matti; Harris, Curtis C.; Chen, Kexin; Hamilton, Stanley R.; Zhang, Wei

    2011-01-01

    Background Colorectal cancer (CRC) remains one of the major cancer types and cancer related death worldwide. Sensitive, non-invasive biomarkers that can facilitate disease detection, staging and prediction of therapeutic outcome are highly desirable to improve survival rate and help to determine optimized treatment for CRC. The small non-coding RNAs, microRNAs (miRNAs), have recently been identified as critical regulators for various diseases including cancer and may represent a novel class of cancer biomarkers. The purpose of this study was to identify and validate circulating microRNAs in human plasma for use as such biomarkers in colon cancer. Methodology/Principal Findings By using quantitative reverse transcription-polymerase chain reaction, we found that circulating miR-141 was significantly associated with stage IV colon cancer in a cohort of 102 plasma samples. Receiver operating characteristic (ROC) analysis was used to evaluate the sensitivity and specificity of candidate plasma microRNA markers. We observed that combination of miR-141 and carcinoembryonic antigen (CEA), a widely used marker for CRC, further improved the accuracy of detection. These findings were validated in an independent cohort of 156 plasma samples collected at Tianjin, China. Furthermore, our analysis showed that high levels of plasma miR-141 predicted poor survival in both cohorts and that miR-141 was an independent prognostic factor for advanced colon cancer. Conclusions/Significance We propose that plasma miR-141 may represent a novel biomarker that complements CEA in detecting colon cancer with distant metastasis and that high levels of miR-141 in plasma were associated with poor prognosis. PMID:21445232

  4. Getting the MAX out of Computational Models: The Prediction of Unbound-Brain and Unbound-Plasma Maximum Concentrations.

    Science.gov (United States)

    Mente, Scot; Doran, Angela; Wager, Travis T

    2012-06-14

    The objective of this work was to establish that unbound maximum concentrations may be reasonably predicted from a combination of computed molecular properties assuming subcutaneous (SQ) dosing. Additionally, we show that the maximum unbound plasma and brain concentrations may be projected from a mixture of in vitro absorption, distribution, metabolism, excretion experimental parameters in combination with computed properties (volume of distribution, fraction unbound in microsomes). Finally, we demonstrate the utility of the underlying equations by showing that the maximum total plasma concentrations can be projected from the experimental parameters for a set of compounds with data collected from clinical research.

  5. In silico prediction of brain exposure: drug free fraction, unbound brain to plasma concentration ratio and equilibrium half-life

    Science.gov (United States)

    Spreafico, Morena; Jacobson, Matthew P.

    2014-01-01

    The focus of CNS drug pharmacokinetics programs has recently shifted from determining the total concentrations in brain and blood to considering also unbound fractions and concentrations. Unfortunately, assessing unbound brain exposure experimentally requires demanding in vivo and in vitro studies. We propose a physical model, based on lipid binding and pH partitioning, to predict in silico the unbound volume of distribution in the brain. The model takes into account the partition of a drug into lipids, interstitial fluid and intracellular compartments of the brain. The results are in good agreement with the experimental data, suggesting that the contributions of lipid binding and pH partitioning are important in determining drug exposure in brain. The predicted values are used, together with predictions for plasma protein binding, as corrective terms in a second model to derive the unbound brain to plasma concentration ratio starting from experimental values of total concentration ratio. The calculated values of brain free fraction and passive permeability are also used to qualitatively determine the brain to plasma equilibration time in a model that shows promising results but is limited to a very small set of compounds. The models we propose are a step forward in understanding and predicting pharmacologically relevant exposure in brain starting from compounds’ chemical structure and neuropharmacokinetics, by using experimental total brain to plasma ratios, in silico calculated properties and simple physics-based approaches. The models can be used in central nervous system drug discovery programs for a fast and cheap assessment of unbound brain exposure. For existing compounds, the unbound ratios can be derived from experimental values of total brain to plasma ratios. For both existing and hypothetical compounds, the unbound volume of distribution due to lipid binding and pH partitioning can be calculated starting only from the chemical structure. PMID:23578025

  6. Plasma burn-through simulations using the DYON code and predictions for ITER

    CERN Document Server

    Kim, Hyun-Tae; de Vries, P C; Contributors, JET-EFDA

    2014-01-01

    This paper will discuss simulations of the full ionization process (i.e. plasma burn-through), fundamental to creating high temperature plasma. By means of an applied electric field, the gas is partially ionized by the electron avalanche process. In order for the electron temperature to increase, the remaining neutrals need to be fully ionized in the plasma burn-through phase, as radiation is the main contribution to the electron power loss. The radiated power loss can be significantly affected by impurities resulting from interaction with the plasma facing components. The DYON code is a plasma burn-through simulator developed at Joint European Torus (JET) [1] [2]. The dynamic evolution of the plasma temperature and plasma densities including impurity content is calculated in a self-consistent way, using plasma wall interaction models. The recent installation of a beryllium wall at JET enabled validation of the plasma burn-through model in the presence of new, metallic plasma facing components. The simulation...

  7. Intergalactic stellar populations in intermediate redshift clusters

    CERN Document Server

    Melnick, J; Toledo, I; Selman, F J; Quintana, H

    2012-01-01

    A substantial fraction of the total stellar mass in rich clusters of galaxies resides in a diffuse intergalactic component usually referred to as the Intra-Cluster Light (ICL). Theoretical models indicate that these intergalactic stars originate mostly from the tidal interaction of the cluster galaxies during the assembly history of the cluster, and that a significant fraction of these stars could have formed in-situ from the late infall of cold metal-poor gas clouds onto the cluster. The models make predictions about the age distribution of the ICL stars, which may provide additional observational constraints. However, these models also over-predict the fraction of stellar mass in the ICL by a substantial margin. Here we present population synthesis models for the ICL of a dumb-bell dominated intermediate redshift (z=0.29) X-ray cluster for which we have deep MOS data obtained with the FORS2 instrument. In a previous paper we have proposed that the dumbell galaxy act as a grinding machine tearing to pieces t...

  8. Prediction of the efficacy of immunotherapy by measuring the integrity of cell-free DNA in plasma in colorectal cancer.

    Science.gov (United States)

    Kitahara, Masahiro; Hazama, Shoichi; Tsunedomi, Ryouichi; Takenouchi, Hiroko; Kanekiyo, Shinsuke; Inoue, Yuka; Nakajima, Masao; Tomochika, Shinobu; Tokuhisa, Yoshihiro; Iida, Michihisa; Sakamoto, Kazuhiko; Suzuki, Nobuaki; Takeda, Shigeru; Ueno, Tomio; Yamamoto, Shigeru; Yoshino, Shigefumi; Nagano, Hiroaki

    2016-12-01

    We previously reported a phase II study of a cancer vaccine using five novel peptides recognized by HLA-A*2402-restricted CTL in combination with oxaliplatin-containing chemotherapy (FXV study) as first-line therapy for patients with metastatic colorectal cancer and demonstrated the safety and promising potential of our five-peptide cocktail. The objective of this analysis was to identify predictive biomarkers for identifying patients who are likely to receive a clinical benefit from immunochemotherapy. Circulating cell-free DNA (cfDNA) in plasma has been reported to be a candidate molecular biomarker for the efficacy of anticancer therapy. Unlike uniformly truncated small-sized DNA released from apoptotic normal cells, DNA released from necrotic cancer cells varies in size. The integrity of plasma cfDNA (i.e. the ratio of longer fragments [400 bp] to shorter fragments [100 bp] of cfDNA), may be clinically useful for detecting colorectal cancer progression. We assessed plasma samples collected from 93 patients prior to receiving immunochemotherapy. The cfDNA levels and integrity were analyzed by semi-quantitative real-time PCR. Progression-free survival was significantly better in patients with a low plasma cfDNA integrity value than in those with a high value (P = 0.0027). Surprisingly, in the HLA-A*2402-matched group, patients with a low plasma cfDNA integrity value had significantly better progression-free survival than those with a high value (P = 0.0015). This difference was not observed in the HLA-A*2402-unmatched group. In conclusion, the integrity of plasma cfDNA may provide important clinical information and may be a useful predictive biomarker of the outcome of immunotherapy in metastatic colorectal cancer.

  9. Lost Baryons at Low Redshift

    CERN Document Server

    Mathur, Smita; Williams, Rik J

    2007-01-01

    We review our attempts to discover lost baryons at low redshift with ``X-ray forest'' of absorption lines from the warm-hot intergalactic medium. We discuss the best evidence to date along the Mrk 421 sightline. We then discuss the missing baryons in the Local Group and the significance of the z=0 absorption systems in X-ray spectra. We argue that the debate over the Galactic vs. extragalactic origin of the z=0 systems is premature as these systems likely contain both components. Observations with next generation X-ray missions such as Constellation-X and XEUS will be crucial to map out the warm-hot intergalactic medium.

  10. Element abundances at high redshift

    Energy Technology Data Exchange (ETDEWEB)

    Meyer, D.M.; Welty, D.E.; York, D.G. (Northwestern Univ., Evanston, IL (USA); Chicago Univ., IL (USA))

    1989-08-01

    Abundances of Si(+), S(+), Cr(+), Mn(+), Fe( ), and Zn(+) are considered for two absorption-line systems in the spectrum of the QSO PKS 0528 - 250. Zinc and sulfur are underabundant, relative to H, by a factor of 10 compared to their solar and Galactic interstellar abundances. The silicon-, chromium-, iron-, and nickel-to-hydrogen ratios are less than the solar values and comparable to the local interstellar ratios. A straightforward interpretation is that nucleosynthesis in these high-redshift systems has led to only about one-tenth as much heavy production as in the gas clouds around the sun, and that the amount of the observed underabundances attributable to grain depletion is small. The dust-to-gas ratio in these clouds is less than 8 percent of the Galactic value. 25 refs.

  11. Element abundances at high redshift

    Science.gov (United States)

    Meyer, David M.; Welty, D. E.; York, D. G.

    1989-01-01

    Abundances of Si(+), S(+), Cr(+), Mn(+), Fe(_), and Zn(+) are considered for two absorption-line systems in the spectrum of the QSO PKS 0528 - 250. Zinc and sulfur are underabundant, relative to H, by a factor of 10 compared to their solar and Galactic interstellar abundances. The silicon-, chromium-, iron-, and nickel-to-hydrogen ratios are less than the solar values and comparable to the local interstellar ratios. A straightforward interpretation is that nucleosynthesis in these high-redshift systems has led to only about one-tenth as much heavy production as in the gas clouds around the sun, and that the amount of the observed underabundances attributable to grain depletion is small. The dust-to-gas ratio in these clouds is less than 8 percent of the Galactic value.

  12. Predicting Progression from Mild Cognitive Impairment to Alzheimer's Dementia Using Clinical, MRI, and Plasma Biomarkers via Probabilistic Pattern Classification.

    Directory of Open Access Journals (Sweden)

    Igor O Korolev

    Full Text Available Individuals with mild cognitive impairment (MCI have a substantially increased risk of developing dementia due to Alzheimer's disease (AD. In this study, we developed a multivariate prognostic model for predicting MCI-to-dementia progression at the individual patient level.Using baseline data from 259 MCI patients and a probabilistic, kernel-based pattern classification approach, we trained a classifier to distinguish between patients who progressed to AD-type dementia (n = 139 and those who did not (n = 120 during a three-year follow-up period. More than 750 variables across four data sources were considered as potential predictors of progression. These data sources included risk factors, cognitive and functional assessments, structural magnetic resonance imaging (MRI data, and plasma proteomic data. Predictive utility was assessed using a rigorous cross-validation framework.Cognitive and functional markers were most predictive of progression, while plasma proteomic markers had limited predictive utility. The best performing model incorporated a combination of cognitive/functional markers and morphometric MRI measures and predicted progression with 80% accuracy (83% sensitivity, 76% specificity, AUC = 0.87. Predictors of progression included scores on the Alzheimer's Disease Assessment Scale, Rey Auditory Verbal Learning Test, and Functional Activities Questionnaire, as well as volume/cortical thickness of three brain regions (left hippocampus, middle temporal gyrus, and inferior parietal cortex. Calibration analysis revealed that the model is capable of generating probabilistic predictions that reliably reflect the actual risk of progression. Finally, we found that the predictive accuracy of the model varied with patient demographic, genetic, and clinical characteristics and could be further improved by taking into account the confidence of the predictions.We developed an accurate prognostic model for predicting MCI-to-dementia progression

  13. Leaky enteric coating on ranitidine hydrochloride beads: dissolution and prediction of plasma data.

    Science.gov (United States)

    Bendas, Ehab R; Ayres, James W

    2008-08-01

    The present research is based on the hypothesis that leaky enteric-coated pellets formulations are able to provide sustained input for drugs that have an absorption window, such as ranitidine hydrochloride, without jeopardizing their bioavailability. Leaky enteric-coated pellets formulations are defined as enteric-coated pellets that allow some of the drug to be released from the formulation in gastric fluid. Different approaches to making leaky enteric-coated pellets were investigated using extrusion-spheronization followed by spray coating. Leaky enteric coats were formulated using a commonly used enteric polymer, Eudragit L 30 D-55, combined with soluble compounds including lactose, PEG 8000 and surfactants (Span 60 (hydrophobic) or Tween 80 (hydrophilic)). The rate of drug release from the formulations in simulated gastric fluid can be tailored by varying the additive's amount or type. All leaky enteric-coated formulations studied completely released the drugs within 30 min after changing dissolution medium to phosphate buffer, pH 6. Predictions of plasma concentration-time profiles of the model drug ranitidine hydrochloride from leaky enteric-coated pellets in fasted conditions and from immediate-release formulations were performed using computer simulations. Simulation results are consistent with a hypothesis that leaky enteric-coated pellets formulations provide sustained input for drugs shown to have an absorption window without decreasing bioavailability. The sustained input results from the combined effects of the formulation and GI transit effects on pellets. The present research demonstrates a new application of knowledge about gastrointestinal transit effects on drug formulations. It also shows that enteric-coating polymers have new applications in areas other than the usual enteric-coated formulations. The hypothesis that a leaky enteric-coated pellets formulation may maintain or increase the bioavailability of drugs that have a window of absorption

  14. Fasting Plasma Glucose and Hemoglobin A1c in Identifying and Predicting Diabetes

    Science.gov (United States)

    Wang, Wenyu; Lee, Elisa T.; Howard, Barbara V.; Fabsitz, Richard R.; Devereux, Richard B.; Welty, Thomas K.

    2011-01-01

    OBJECTIVE To compare fasting plasma glucose (FPG) and HbA1c in identifying and predicting type 2 diabetes in a population with high rates of diabetes. RESEARCH DESIGN AND METHODS Diabetes was defined as an FPG level ≥126 mg/dL or an HbA1c level ≥6.5%. Data collected from the baseline and second exams (1989–1995) of the Strong Heart Study were used. RESULTS For cases of diabetes identified by FPG ≥126 mg/dL, using HbA1c ≥6.5% at the initial and 4-year follow-up diabetes screenings (or in identifying incident cases in 4 years) among undiagnosed participants left 46% and 59% of cases of diabetes undetected, respectively, whereas for cases identified by HbA1c ≥6.5%, using FPG ≥126 mg/dL left 11% and 59% unidentified, respectively. Age, waist circumference, urinary albumin-to-creatinine ratio, and baseline FPG and HbA1c levels were common significant risk factors for incident diabetes defined by either FPG or HbA1c; triglyceride levels were significant for diabetes defined by HbA1c alone, and blood pressure and sibling history of diabetes were significant for diabetes defined by FPG alone. Using both the baseline FPG and HbA1c in diabetes prediction identified more people at risk than using either measure alone. CONCLUSIONS Among undiagnosed participants, using HbA1c alone in initial diabetes screening identifies fewer cases of diabetes than FPG, and using either FPG or HbA1c alone cannot effectively identify diabetes in a 4-year periodic successive diabetes screening or incident cases of diabetes in 4 years. Using both criteria may identify more people at risk. The proposed models using the commonly available clinical measures can be applied to assessing the risk of incident diabetes using either criterion. PMID:21270194

  15. Gamma-ray bursts at high redshift

    NARCIS (Netherlands)

    R.A.M.J. Wijers

    1999-01-01

    Gamma-ray bursts are much brighter than supernovae, and could therefore possibly probe the Universe to high redshift. The presently established GRB redshifts range from 0.83 to 5, and quite possibly even beyond that. Since most proposed mechanisms for GRB link them closely to deaths of massive stars

  16. Photometric Redshifts of Galaxies in COSMOS

    CERN Document Server

    Mobasher, B; Scoville, N Z; Dahlen, T; Salvato, M; Aussel, H; Thompson, D J; Feldmann, R; Tasca, L; Lefèvre, O; Lilly, S; Carollo, C M; Kartaltepe, J S; McCracken, H; Mould, J; Renzini, A; Sanders, D B; Shopbell, P L; Taniguchi, Y; Ajiki, M; Shioya, Y; Contini, T; Giavalisco, M; Ilbert, O; Iovino, A; Le Brun, V; Mainieri, V; Mignoli, M; Scodeggio, M

    2006-01-01

    We measure photometric redshifts and spectral types for galaxies in the COSMOS survey. We use template fitting technique combined with luminosity function priors and with the option to simultaneously estimate dust extinction (i.e. E(B-V)) for each galaxy.Our estimated redshifts are accurate to i<25 and z~1.2. Using simulations with sampling and noise characteristics similar to those in COSMOS, the accuracy and reliability is estimated for the photometric redshifts as a function of the magnitude limits of the sample, S/N ratios and the number of bands used. From the simulations we find that the ratio of derived 95% confidence interval in the redshift probability distribution to the estimated photometric redshift (D95) can be used to identify and exclude the catastrophic failures in the photometric redshift estimates. We compare the derived redshifts with high-reliability spectroscopic redshifts for a sample of 868 normal galaxies with z < 1.2 from zCOSMOS. Considering different scenarios, depending on us...

  17. Photometric redshifts for the CFHTLS-Wide

    CERN Document Server

    Brimioulle, Fabrice; Seitz, Stella; Bender, Ralf; Snigula, Jan

    2008-01-01

    We want to derive bias free, accurate photometric redshifts for those fields of the CFHTLS-Wide data which are covered in the u*, g', r', i' and z' filters and are public on January 2008. These are 37 square degrees in the W1, W3 and W4 fields with photometric data for a total of 2.597.239 galaxies. We use the photometric redshift code PHOTO-z of Bender et al. (2001). We compare our redshifts for the W1, W3 and W4 fields to about 7500 spectroscopic redshifts from the VVDS therein. For galaxies with 17.5 <= i' AB <= 22.5 the accuracies and outlier rates become sigma=0.033, eta~2 % for W1, sigma=0.037, eta~2% for W3 and sigma=0.035, eta~2.5 % outliers for W4 fields. For the total galaxy sample with about 9000 spectroscopic redshifts from VVDS, DEEP2 or SDSS we obtain a sigma=0.04 and eta~5.7% for the PHOTO-z redshifts. We consider the photometric redshifts of Erben et al. (2008) which were obtained with exactly the same photometric catalog using the BPZ-redshift code and compare them with our computed red...

  18. High Redshift Lyman-α Hunt

    DEFF Research Database (Denmark)

    Kochiashvili, Ia

    constitute the backbone of thisthesis, I investigated the nature of almost 100 emission-line galaxies selected with thenarrow-band selection method. These candidates can be: galaxies with Hα emissionlines at redshift z ∼ 0.6, [Oiii]/Hβ emission-line galaxies at redshift z ∼ 1.15 and [Oii]emitters at z ∼ 1...

  19. Photometric Redshifts in the IRAC Shallow Survey

    Energy Technology Data Exchange (ETDEWEB)

    Brodwin, M; Brown, M; Ashby, M; Bian, C; Brand, K; Dey, A; Eisenhardt, P; Eisenstein, D; Gonzalez, A; Huang, J; Kochanek, C; McKenzie, E; Pahre, M; Smith, H; Soifer, B; Stanford, S; Stern, D; Elston, R

    2006-06-13

    Accurate photometric redshifts are calculated for nearly 200,000 galaxies to a 4.5 micron flux limit of {approx} 13 {micro}Jy in the 8.5 deg{sup 2} Spitzer/IRAC Shallow survey. Using a hybrid photometric redshift algorithm incorporating both neural-net and template-fitting techniques, calibrated with over 15,000 spectroscopic redshifts, a redshift accuracy of {sigma} = 0.06 (1+z) is achieved for 95% of galaxies at 0 < z < 1.5. The accuracy is {sigma} = 0.12 (1 + z) for 95% of AGN at 0 < z < 3. Redshift probability functions, central to several ongoing studies of the galaxy population, are computed for the full sample. We demonstrate that these functions accurately represent the true redshift probability density, allowing the calculation of valid confidence intervals for all objects. These probability functions have already been used to successfully identify a population of Spitzer-selected high redshift (z > 1) galaxy clusters. We present one such spectroscopically confirmed cluster at = 1.24, ISCS J1434.2+3426. Finally, we present a measurement of the 4.5 {micro}m-selected galaxy redshift distribution.

  20. Gamma-ray bursts at high redshift

    NARCIS (Netherlands)

    Wijers, R.A.M.J.

    1999-01-01

    Gamma-ray bursts are much brighter than supernovae, and could therefore possibly probe the Universe to high redshift. The presently established GRB redshifts range from 0.83 to 5, and quite possibly even beyond that. Since most proposed mechanisms for GRB link them closely to deaths of massive stars

  1. Plasma apolipoprotein M is reduced in metabolic syndrome but does not predict intima media thickness

    NARCIS (Netherlands)

    Dullaart, Robin P. F.; Plomgaard, Peter; de Vries, Rindert; Dahlback, Bjorn; Nielsen, Lars B.

    2009-01-01

    Background: Apolipoprotein (apo) M may exert anti-atherogenic properties in experimental studies. Its hepatic gene expression may be linked to glucose and lipid metabolism. Plasma apoM is decreased in obese mouse models. We hypothesized that plasma apoM is lower in metabolic syndrome (MetS) subjects

  2. Plasma burn-through simulations using the DYON code and predictions for ITER

    NARCIS (Netherlands)

    Kim, H. T.; Sips, A.C.C.; de Vries, P. C.; JET-EFDA Contributors,

    2013-01-01

    This paper will discuss simulations of the full ionization process (i.e. plasma burn-through), fundamental to creating high temperature plasma. By means of an applied electric field, the gas is partially ionized by the electron avalanche process. In order for the electron temperature to increase, th

  3. Real-time cosmography with redshift derivatives

    Science.gov (United States)

    Martins, C. J. A. P.; Martinelli, M.; Calabrese, E.; Ramos, M. P. L. P.

    2016-08-01

    The drift in the redshift of objects passively following the cosmological expansion has long been recognized as a key model-independent probe of cosmology. Here, we study the cosmological relevance of measurements of time or redshift derivatives of this drift, arguing that the combination of first and second redshift derivatives is a powerful test of the Λ CDM cosmological model. In particular, the latter can be obtained numerically from a set of measurements of the drift at different redshifts. We show that, in the low-redshift limit, a measurement of the derivative of the drift can provide a constraint on the jerk parameter, which is j =1 for flat Λ CDM , while generically j ≠1 for other models. We emphasize that such a measurement is well within the reach of the ELT-HIRES and SKA Phase 2 array surveys.

  4. CuBANz: Photometric redshift estimator

    Science.gov (United States)

    Samui, Saumyadip; Pal, Shanoli Samui

    2016-09-01

    CuBANz is a photometric redshift estimator code for high redshift galaxies that uses the back propagation neural network along with clustering of the training set, making it very efficient. The training set is divided into several self learning clusters with galaxies having similar photometric properties and spectroscopic redshifts within a given span. The clustering algorithm uses the color information (i.e. u-g, g-r etc.) rather than the apparent magnitudes at various photometric bands, as the photometric redshift is more sensitive to the flux differences between different bands rather than the actual values. The clustering method enables accurate determination of the redshifts. CuBANz considers uncertainty in the photometric measurements as well as uncertainty in the neural network training. The code is written in C.

  5. The kinematic component of the cosmological redshift

    CERN Document Server

    Chodorowski, Michał

    2009-01-01

    It is widely believed that the cosmological redshift is not a Doppler shift. However, Bunn & Hogg have recently pointed out that to settle properly this problem, one has to transport parallelly the velocity four-vector of a distant galaxy to the observer's position. Performing such a transport along the null geodesic of photons arriving from the galaxy, they found that the cosmological redshift is purely kinematic. Here we argue that one should rather transport the velocity four-vector along the geodesic connecting the points of intersection of the world-lines of the galaxy and the observer with the hypersurface of constant COSMIC TIME. We find that the resulting relation between the transported velocity and the redshift of arriving photons is NOT given by a relativistic Doppler formula. Instead, for small redshifts it coincides with the well known non-relativistic decomposition of the redshift into a Doppler (kinematic) component and a gravitational component. We perform such a decomposition for arbitrar...

  6. Real-time cosmography with redshift derivatives

    CERN Document Server

    Martins, C J A P; Calabrese, E; Ramos, M P L P

    2016-01-01

    The drift in the redshift of objects passively following the cosmological expansion has long been recognized as a key model-independent probe of cosmology. Here, we study the cosmological relevance of measurements of time or redshift derivatives of this drift, arguing that the combination of first and second redshift derivatives is a powerful test of the $\\Lambda$CDM cosmological model. In particular, the latter can be obtained numerically from a set of measurements of the drift at different redshifts. We show that, in the low-redshift limit, a measurement of the derivative of the drift can provide a constraint on the jerk parameter, which is $j=1$ for flat $\\Lambda$CDM, while generically $j\

  7. Prediction of heating rate controlled viscous flow activation energy during spark plasma sintering of amorphous alloy powders

    Science.gov (United States)

    Paul, Tanaji; Harimkar, Sandip P.

    2017-07-01

    The viscous flow behavior of Fe-based amorphous alloy powder during isochronal spark plasma sintering was analyzed under the integrated theoretical background of the Arrhenius and directional structural relaxation models. A relationship between viscous flow activation energy and heating rate was derived. An extension of the pertinent analysis to Ti-based amorphous alloys confirmed the broad applicability of such a relationship for predicting the activation energy for sintering below the glass transition temperature (T g) of the amorphous alloy powders.

  8. Origin of redshift asymmetries: How LambdaCDM explains anomalous redshift

    CERN Document Server

    Niemi, Sami-Matias

    2008-01-01

    Several authors have found a statistically significant excess of galaxies with higher redshifts relative to the group centre, so called discordant redshifts, in particular in groups where the brightest galaxy, identified in apparent magnitudes, is a spiral. Our aim is to explain the observed redshift excess. We use a semi-analytical galaxy catalogue constructed from the Millennium Simulation to study redshift asymmetries in spiral-dominated groups in the Lambda cold dark matter (LambdaCDM) cosmology. We show that discordant redshifts in small galaxy groups arise when these groups are gravitationally unbound and the dominant galaxy of the group is misidentified. The redshift excess is especially significant when the apparently brightest galaxy can be identified as a spiral, in full agreement with observations. On the other hand, the groups that are gravitationally bound do not show a significant redshift asymmetry. When the dominant members of groups in mock catalogues are identified by using the absolute B-ba...

  9. Machine-z: Rapid Machine-Learned Redshift Indicator for Swift Gamma-Ray Bursts

    Science.gov (United States)

    Ukwatta, T. N.; Wozniak, P. R.; Gehrels, N.

    2016-01-01

    Studies of high-redshift gamma-ray bursts (GRBs) provide important information about the early Universe such as the rates of stellar collapsars and mergers, the metallicity content, constraints on the re-ionization period, and probes of the Hubble expansion. Rapid selection of high-z candidates from GRB samples reported in real time by dedicated space missions such as Swift is the key to identifying the most distant bursts before the optical afterglow becomes too dim to warrant a good spectrum. Here, we introduce 'machine-z', a redshift prediction algorithm and a 'high-z' classifier for Swift GRBs based on machine learning. Our method relies exclusively on canonical data commonly available within the first few hours after the GRB trigger. Using a sample of 284 bursts with measured redshifts, we trained a randomized ensemble of decision trees (random forest) to perform both regression and classification. Cross-validated performance studies show that the correlation coefficient between machine-z predictions and the true redshift is nearly 0.6. At the same time, our high-z classifier can achieve 80 per cent recall of true high-redshift bursts, while incurring a false positive rate of 20 per cent. With 40 per cent false positive rate the classifier can achieve approximately 100 per cent recall. The most reliable selection of high-redshift GRBs is obtained by combining predictions from both the high-z classifier and the machine-z regressor.

  10. A physiologically based pharmacokinetic model to predict the pharmacokinetics of highly protein-bound drugs and the impact of errors in plasma protein binding.

    Science.gov (United States)

    Ye, Min; Nagar, Swati; Korzekwa, Ken

    2016-04-01

    Predicting the pharmacokinetics of highly protein-bound drugs is difficult. Also, since historical plasma protein binding data were often collected using unbuffered plasma, the resulting inaccurate binding data could contribute to incorrect predictions. This study uses a generic physiologically based pharmacokinetic (PBPK) model to predict human plasma concentration-time profiles for 22 highly protein-bound drugs. Tissue distribution was estimated from in vitro drug lipophilicity data, plasma protein binding and the blood: plasma ratio. Clearance was predicted with a well-stirred liver model. Underestimated hepatic clearance for acidic and neutral compounds was corrected by an empirical scaling factor. Predicted values (pharmacokinetic parameters, plasma concentration-time profile) were compared with observed data to evaluate the model accuracy. Of the 22 drugs, less than a 2-fold error was obtained for the terminal elimination half-life (t1/2 , 100% of drugs), peak plasma concentration (Cmax , 100%), area under the plasma concentration-time curve (AUC0-t , 95.4%), clearance (CLh , 95.4%), mean residence time (MRT, 95.4%) and steady state volume (Vss , 90.9%). The impact of fup errors on CLh and Vss prediction was evaluated. Errors in fup resulted in proportional errors in clearance prediction for low-clearance compounds, and in Vss prediction for high-volume neutral drugs. For high-volume basic drugs, errors in fup did not propagate to errors in Vss prediction. This is due to the cancellation of errors in the calculations for tissue partitioning of basic drugs. Overall, plasma profiles were well simulated with the present PBPK model. Copyright © 2016 John Wiley & Sons, Ltd.

  11. Understanding redshift space distortions in density-weighted peculiar velocity

    CERN Document Server

    Sugiyama, Naonori S; Spergel, David N

    2015-01-01

    Observations of the kinetic Sunyaev-Zel'dovich (kSZ) effect measure the density-weighted velocity field, a potentially powerful cosmological probe. This paper presents an analytical method to predict the power spectrum and two-point correlation function of the density-weighted velocity in redshift space, the direct observables in kSZ surveys. We show a simple relation between the density power spectrum and the density-weighted velocity power spectrum that holds for both dark matter and halos. Using this relation, we can then extend familiar perturbation expansion techniques to the kSZ power spectrum. One of the most important features of the density-weighted velocity is the change of the sign of infall velocity at small scales due to the nonlinear redshift space distortion. Our model can explain this characteristic feature without any free parameters. As a result, our results can precisely predict the non-linear behavior of the density-weighted velocity field in redshift space up to $\\sim10\\ h^{-1} {\\rm Mpc}$...

  12. Plasma apolipoprotein M is reduced in metabolic syndrome but does not predict intima media thickness

    DEFF Research Database (Denmark)

    Dullaart, Robin P F; Plomgaard, Peter; de Vries, Rindert

    2009-01-01

    BACKGROUND: Apolipoprotein (apo) M may exert anti-atherogenic properties in experimental studies. Its hepatic gene expression may be linked to glucose and lipid metabolism. Plasma apoM is decreased in obese mouse models. We hypothesized that plasma apoM is lower in metabolic syndrome (Met......S) subjects, and determined whether intima media thickness (IMT) is associated with apoM. METHODS: In 19 non-diabetic subjects with and 60 non-diabetic subjects without MetS (NCEP, ATP III criteria), the relationships of plasma apoM with obesity, glucose, insulin, lipids and adipokines, as well as with IMT...

  13. Scalar potential model of redshift and discrete redshift

    CERN Document Server

    Hodge, J C

    2006-01-01

    On the galactic scale the universe is inhomogeneous and redshift $z$ is occasionally less than zero. A scalar potential model (SPM) that links the galaxy scale $z$ to the cosmological scale $z$ of the Hubble Law is postulated. Several differences among galaxy types suggest that spiral galaxies are Sources and that early type, lenticular, and irregular galaxies are Sinks of a scalar potential field. The morphology-radius and the intragalactic medium cluster observations support the movement of matter from Source galaxies to Sink galaxies. A cell structure of galaxy groups and clusters is proposed to resolve a paradox concerning the scalar potential like the Olber's paradox concerning light. For the sample galaxies, the ratio of the luminosity of Source galaxies to the luminosity of Sink galaxies approaches $2.7 \\pm 0.1$. An equation is derived from sample data, which is anisotropic and inhomogeneous, relating $z$ of and the distance $D$ to galaxies. The calculated $z$ has a correlation coefficient of 0.88 with...

  14. Iron Abundance Diagnostics in High-Redshift QSOs

    CERN Document Server

    Corbin, M R; Freduling, N K W; Corbin, Michael R.; Korista, Kirk T.; Freduling, Nalaka Kodituwakku & Wolfram

    2004-01-01

    The abundance of alpha-process elements such as magnesium and carbon relative to iron measured from the broad emission lines of QSOs can serve as a diagnostic of the star formation and chemical enrichment histories of their host galaxies. We investigate the relationship between Fe/Mg and Fe/C abundance ratios and the resulting Fe II / Mg II 2800A and Fe II / 1900A-blend flux ratios, both of which have been measured in QSOs out to redshifts of approximately six. Using a galactic chemical evolution model based on a starburst in a giant elliptical galaxy, we find that these flux ratios are good tracers of the chemical enrichment of the nuclei. However, the values of these ratios measured in objects at redshifts of approximately six suggest that iron enrichment has occurred more rapidly in these objects than predicted by the assumed elliptical starburst model, under currently favored cosmologies.

  15. Early involvement in friendships predicts later plasma concentrations of oxytocin and vasopressin in juvenile rhesus macaques (Macaca mulatta

    Directory of Open Access Journals (Sweden)

    Tamara Aliza Rachel Weinstein

    2014-08-01

    Full Text Available The neuropeptides oxytocin (OT and vasopressin (AVP are involved in social bonding in attachment relationships, but their role in friendship is poorly understood. We investigated whether rhesus macaques’ (Macaca mulatta friendships at age one predicted plasma OT and AVP at two later time points. Subjects were 54 rhesus macaques at the California National Primate Research Center. Blood was drawn during a brief capture-and-release in the home cage, and plasma assayed for OT and AVP using an enzyme immunoassay. Separate linear mixed models for each sex tested the effects of dominance rank, age, sampling time point, housing condition, parturition status, two blood draw timing measures, and five friendship types: proximity friendships, play friendships, reciprocal friendships (a preference for a peer that also preferred the subject, multiplex friendships (friendships displayed in more than one behavioral domain, and total number of friendships. Females’ number of reciprocal and play friendships at age one significantly predicted later OT; additionally, these two friendship types interacted with rank, such that high-ranking females with the fewest friendships had the highest OT concentrations. Friendship did not predict later OT levels in males, however proximity, play, reciprocal, and total number of friendships predicted males’ plasma AVP. Play and total number of friendships also tended to predict AVP in females. Our results show that peripheral measures of neuroendocrine functioning in juvenile rhesus monkeys are influenced by early involvement in friendships. Friendships have an especially strong impact on an individual’s psychosocial development, and our data suggest OT and AVP as potential underlying mechanisms. Moreover, sex differences in the functioning of the OT and AVP systems, and their relation to friendship, may have important clinical implications for the use of OT as a therapeutic, as well as informing the social context in

  16. Pre to post-dialysis plasma sodium change better predicts clinical outcomes than dialysate to plasma sodium gradient in quotidian hemodialysis.

    Science.gov (United States)

    Thomson, Benjamin K A; Huang, Shih-Han S; Leitch, Rosemary E; Dixon, Stephanie; Heidenheim, Paul; Suri, Rita S; Chan, Christopher T; Lindsay, Robert M

    2013-10-01

    Sodium balance across a hemodialysis treatment influences interdialytic weight gain (IDWG), pre-dialysis blood pressure, and the occurrence of intradialytic hypotension, which associate with patient morbidity and mortality. In thrice weekly conventional hemodialysis patients, the dialysate sodium minus pre-dialysis plasma sodium concentration (δDPNa+) and the post-dialysis minus pre-dialysis plasma sodium (δPNa+) are surrogates of sodium balance, and are associated with both cardiovascular and all-cause mortality. However, whether δDPNa+ or δPNa+ better predicts clinical outcomes in quotidian dialysis is unknown. We performed a retrospective analysis of clinical and demographic data from the Southwestern Ontario Regional Home Hemodialysis program, of all patients since 1985. In frequent nocturnal hemodialysis, δPNa+ was superior to δDPNa+ in predicting IDWG (R(2)=0.223 vs. 0.020, P=0.002 vs. 0.76), intradialytic change in systolic (R(2)=0.100 vs. 0.002, P=0.02 vs. 0.16) and diastolic (R(2)=0.066 vs. 0.019, P=0.02 vs. 0.06) blood pressure, and ultrafiltration rate (R(2)=0.296 vs. 0.036, P=0.001 vs. 0.52). In short hours daily hemodialysis, δDPNa+ was better than δPNa+ in predicting intradialytic change in diastolic blood pressure (R(2)=0.101 vs. 0.003, P=0.02 vs. 0.13). However, δPNa+ was better than δDPNa+ in predicting IDWG (R(2)=0.105 vs. 0.019, P=0.04 vs. 0.68) and pre-dialysis systolic blood pressure (R(2)=0.103 vs. 0.007, P=0.02 vs. 0.82). We also found that the intradialytic blood pressure fall was greater in frequent nocturnal hemodialysis patients than in short hours daily patients, when exposed to a dialysate to plasma sodium gradient. These results provide a basis for design of prospective trials in quotidian dialysis modalities, to determine the effect of sodium balance on cardiovascular outcome.

  17. IONIZED NITROGEN AT HIGH REDSHIFT

    Energy Technology Data Exchange (ETDEWEB)

    Decarli, R.; Walter, F. [Max-Planck Institut fuer Astronomie, Koenigstuhl 17, D-69117 Heidelberg (Germany); Neri, R.; Cox, P. [IRAM, 300 rue de la piscine, F-38406 Saint-Martin d' Heres (France); Bertoldi, F. [Argelander Institute for Astronomy, University of Bonn, Auf dem Huegel 71, D-53121 Bonn (Germany); Carilli, C. [NRAO, Pete V. Domenici Array Science Center, P.O. Box O, Socorro, NM 87801 (United States); Kneib, J. P. [Laboratoire d' Astrophysique de Marseille, Observatoire d' Astronomie Marseille-Provence, BP 8, F-13376 Marseille (France); Lestrade, J. F. [Observatoire de Paris, CNRS, 61 Av. de l' Observatoire, F-75014 Paris (France); Maiolino, R. [INAF-Osservatorio Astronomico di Roma, via di Frascati 33, I-00040 Monte Porzio Catone (Italy); Omont, A. [Institut d' Astrophysique de Paris, UPMC and CNRS, 98bis Bld. Arago, F-75014 Paris (France); Richard, J. [CRAL, Observatoire de Lyon, Universite Lyon 1, 9 Avenue Ch. Andre, F-69561 Saint Genis Laval Cedex (France); Riechers, D. [Astronomy Department, Caltech, 1200 East California Boulevard, Pasadena, CA 91125 (United States); Thanjavur, K. [Canada-France-Hawaii Telescope Corporation, HI 96743 (United States); Weiss, A., E-mail: decarli@mpia.de [Max-Planck-Institut fuer Radioastronomie, Auf dem Huegel 69, D-53121 Bonn (Germany)

    2012-06-10

    We present secure [N II]{sub 205{mu}m} detections in two millimeter-bright, strongly lensed objects at high redshift, APM 08279+5255 (z = 3.911) and MM 18423+5938 (z = 3.930), using the IRAM Plateau de Bure Interferometer. Due to its ionization energy [N II]{sub 205{mu}m} is a good tracer of the ionized gas phase in the interstellar medium. The measured fluxes are S([N II]{sub 205{mu}m}) = (4.8 {+-} 0.8) Jy km s{sup -1} and (7.4 {+-} 0.5) Jy km s{sup -1}, respectively, yielding line luminosities of L([N II]{sub 205{mu}m}) = (1.8 {+-} 0.3) Multiplication-Sign 10{sup 9} {mu}{sup -1} L{sub Sun} for APM 08279+5255 and L([N II]{sub 205{mu}m}) = (2.8 {+-} 0.2) Multiplication-Sign 10{sup 9} {mu}{sup -1} L{sub Sun} for MM 18423+5938. Our high-resolution map of the [N II]{sub 205{mu}m} and 1 mm continuum emission in MM 18423+5938 clearly resolves an Einstein ring in this source and reveals a velocity gradient in the dynamics of the ionized gas. A comparison of these maps with high-resolution EVLA CO observations enables us to perform the first spatially resolved study of the dust continuum-to-molecular gas surface brightness ({Sigma}{sub FIR}{proportional_to}{Sigma}{sup N}{sub CO}, which can be interpreted as the star formation law) in a high-redshift object. We find a steep relation (N = 1.4 {+-} 0.2), consistent with a starbursting environment. We measure a [N II]{sub 205{mu}m}/FIR luminosity ratio in APM 08279+5255 and MM 18423+5938 of 9.0 Multiplication-Sign 10{sup -6} and 5.8 Multiplication-Sign 10{sup -6}, respectively. This is in agreement with the decrease of the [N II]{sub 205{mu}m}/FIR ratio at high FIR luminosities observed in local galaxies.

  18. Thermodynamics Insights for the Redshift Drift

    Science.gov (United States)

    Zhang, Ming-Jian; Liu, Wen-Biao

    2015-01-01

    The secular redshift drift is a potential measurement to directly probe the cosmic expansion. Previous study on the redshift drift mainly focused on the model-dependent simulation. Apparently, the physical insights on the redshift drift are very necessary. So in this paper, it is investigated using thermodynamics on the apparent, Hubble and event horizons. Thermodynamics could analytically present the model-independent upper bounds of redshift drift. For specific assumption on the cosmological parameters, we find that the thermodynamics bounds are nearly one order of magnitude larger than the expectation in standard ΛCDM model. We then examine ten observed redshift drift from Green Bank Telescope at redshift 0.09 < z < 0.69, and find that these observational results are inconsistent with the thermodynamics. The size of the errorbars on these measurements is about three orders of magnitude larger than the effect of thermodynamical bounds for the redshift drift. Obviously, we have not yet hit any instrumental systematics at the shift level of 1m s-1 yr-1.

  19. Constraining Source Redshift Distributions with Gravitational Lensing

    CERN Document Server

    Wittman, D

    2012-01-01

    We introduce a new method for constraining the redshift distribution of a set of galaxies, using weak gravitational lensing shear. Instead of using observed shears and redshifts to constrain cosmological parameters, we ask how well the shears around clusters can constrain the redshifts, assuming fixed cosmological parameters. This provides a check on photometric redshifts, independent of source spectral energy distribution properties and therefore free of confounding factors such as misidentification of spectral breaks. We find that ~40 massive ($\\sigma_v=1200$ km/s) cluster lenses are sufficient to determine the fraction of sources in each of six coarse redshift bins to ~11%, given weak (20%) priors on the masses of the highest-redshift lenses, tight (5%) priors on the masses of the lowest-redshift lenses, and only modest (20-50%) priors on calibration and evolution effects. Additional massive lenses drive down uncertainties as $N_{lens}^0.5$, but the improvement slows as one is forced to use lenses further ...

  20. Giving cosmic redshift drift a whirl

    Science.gov (United States)

    Kim, Alex G.; Linder, Eric V.; Edelstein, Jerry; Erskine, David

    2015-03-01

    Redshift drift provides a direct kinematic measurement of cosmic acceleration but it occurs with a characteristic time scale of a Hubble time. Thus redshift observations with a challenging precision of 10-9 require a 10 year time span to obtain a signal-to-noise of 1. We discuss theoretical and experimental approaches to address this challenge, potentially requiring less observer time and having greater immunity to common systematics. On the theoretical side we explore allowing the universe, rather than the observer, to provide long time spans; speculative methods include radial baryon acoustic oscillations, cosmic pulsars, and strongly lensed quasars. On the experimental side, we explore beating down the redshift precision using differential interferometric techniques, including externally dispersed interferometers and spatial heterodyne spectroscopy. Low-redshift emission line galaxies are identified as having high cosmology leverage and systematics control, with an 8 h exposure on a 10-m telescope (1000 h of exposure on a 40-m telescope) potentially capable of measuring the redshift of a galaxy to a precision of 10-8 (few ×10-10). Low-redshift redshift drift also has very strong complementarity with cosmic microwave background measurements, with the combination achieving a dark energy figure of merit of nearly 300 (1400) for 5% (1%) precision on drift.

  1. Potential role of plasma myeloperoxidase level in predicting long-term outcome of acute myocardial infarction.

    Science.gov (United States)

    Kaya, Mehmet Gungor; Yalcin, Ridvan; Okyay, Kaan; Poyraz, Fatih; Bayraktar, Nilufer; Pasaoglu, Hatice; Boyaci, Bulent; Cengel, Atiye

    2012-01-01

    We investigated the prognostic importance of plasma myeloperoxidase levels in patients with ST-elevation myocardial infarction (STEMI) at long-term follow-up, and we analyzed the correlations between plasma myeloperoxidase levels and other biochemical values. We evaluated 73 consecutive patients (56 men; mean age, 56 ± 11 yr) diagnosed with acute STEMI and 46 age- and sex-matched healthy control participants. Patients were divided into 2 groups according to the median myeloperoxidase level (Group 1: plasma myeloperoxidase ≤ 68 ng/mL; and Group 2: plasma myeloperoxidase > 68 ng/mL). Patients were monitored for the occurrence of major adverse cardiovascular events (MACE), which were defined as cardiac death; reinfarction; new hospital admission for angina; heart failure; and revascularization procedures. The mean follow-up period was 25 ± 16 months. Plasma myeloperoxidase levels were higher in STEMI patients than in control participants (82 ± 34 vs 20 ± 12 ng/mL; P = 0.001). Composite MACE occurred in 12 patients with high myeloperoxidase levels (33%) and in 4 patients with low myeloperoxidase levels (11%) (P = 0.02). The incidences of nonfatal recurrent myocardial infarction and verified cardiac death were higher in the high-myeloperoxidase group. In multivariate analysis, high plasma myeloperoxidase levels were independent predictors of MACE (odds ratio = 3.843; <95% confidence interval, 1.625-6.563; P = 0.003). High plasma myeloperoxidase levels identify patients with a worse prognosis after acute STEMI at 2-year follow-up. Evaluation of plasma myeloperoxidase levels might be useful in determining patients at high risk of death and MACE who can benefit from further aggressive treatment and closer follow-up.

  2. Fundamental Mechanisms, Predictive Modeling, and Novel Aerospace Applications of Plasma Assisted Combustion

    Science.gov (United States)

    2011-11-01

    rich low temperature chemistry Pressure: 1 atm DME model: Zhao et al., Int. J. Chem. Kinet ., (40) 2008 37 Flow tube experiments DME : rich low... Kinetic enhancement Fuel fragmentsTemperature increase Transport enhancementThermal enhancement Radicals H2, CO CH4 Understanding: Good poor O, NO O2(a∆g...plasma flame kinetic mechanism Develop numerical methods to achieve efficient modeling of detailed plasma flame chemistry 5 Outline 1. Background 2

  3. Pathogen inactivation treatment of plasma and platelet concentrates and their predicted functionality in massive transfusion protocols.

    Science.gov (United States)

    Arbaeen, Ahmad F; Schubert, Peter; Serrano, Katherine; Carter, Cedric J; Culibrk, Brankica; Devine, Dana V

    2017-05-01

    Trauma transfusion packages for hemorrhage control consist of red blood cells, plasma, and platelets at a set ratio. Although pathogen reduction improves the transfusion safety of platelet and plasma units, there is an associated reduction in quality. This study aimed to investigate the impact of riboflavin/ultraviolet light-treated plasma or platelets in transfusion trauma packages composed of red blood cell, plasma, and platelet units in a ratio of 1:1:1 in vitro by modeling transfusion scenarios for trauma patients and assessing function by rotational thromboelastometry. Pathogen-reduced or untreated plasma and buffy coat platelet concentrate units produced in plasma were used in different combinations with red blood cells in trauma transfusion packages. After reconstitution of these packages with hemodiluted blood, the hemostatic functionality was analyzed by rotational thromboelastometry. Hemostatic profiles of pathogen-inactivated buffy coat platelet concentrate and plasma indicated decreased activity compared with their respective controls. Reconstitution of hemodiluted blood (hematocrit = 20%) with packages that contained treated or nontreated components resulted in increased alpha and maximum clot firmness and enhanced clot-formation time. Simulating transfusion scenarios based on 30% blood replacement with a transfusion trauma package resulted in a nonsignificant difference in rotational thromboelastometry parameters between packages containing treated and nontreated blood components (p ≥ 0.05). Effects of pathogen inactivation treatment were evident when the trauma package percentage was 50% or greater and contained both pathogen inactivation-treated plasma and buffy coat platelet concentrate. Rotational thromboelastometry investigations suggest that there is relatively little impact of pathogen inactivation treatment on whole blood clot formation unless large amounts of treated components are used. © 2017 AABB.

  4. Urine and plasma metabolites predict the development of diabetic nephropathy in individuals with Type 2 diabetes mellitus.

    Science.gov (United States)

    Pena, M J; Lambers Heerspink, H J; Hellemons, M E; Friedrich, T; Dallmann, G; Lajer, M; Bakker, S J L; Gansevoort, R T; Rossing, P; de Zeeuw, D; Roscioni, S S

    2014-09-01

    Early detection of individuals with Type 2 diabetes mellitus or hypertension at risk for micro- or macroalbuminuria may facilitate prevention and treatment of renal disease. We aimed to discover plasma and urine metabolites that predict the development of micro- or macroalbuminuria. Patients with Type 2 diabetes (n = 90) and hypertension (n = 150) were selected from the community-cohort 'Prevention of REnal and Vascular End-stage Disease' (PREVEND) and the Steno Diabetes Center for this case-control study. Cases transitioned in albuminuria stage (from normo- to microalbuminuria or micro- to macroalbuminuria). Controls, matched for age, gender, and baseline albuminuria stage, remained in normo- or microalbuminuria stage during follow-up. Median follow-up was 2.9 years. Metabolomics were performed on plasma and urine. The predictive performance of a metabolite for albuminuria transition was assessed by the integrated discrimination index. In patients with Type 2 diabetes with normoalbuminuria, no metabolites discriminated cases from controls. In patients with Type 2 diabetes with microalbuminuria, plasma histidine was lower (fold change = 0.87, P = 0.02) and butenoylcarnitine was higher (fold change = 1.17, P = 0.007) in cases vs. controls. In urine, hexose, glutamine and tyrosine were lower in cases vs. controls (fold change = 0.20, P diabetes. Type 2 diabetes-specific plasma and urine metabolites were discovered that predict the development of macroalbuminuria beyond established renal risk markers. These results should be confirmed in a large, prospective cohort. © 2014 The Authors. Diabetic Medicine © 2014 Diabetes UK.

  5. Plasma oxytocin but not prostaglandin F2 alpha metabolite levels at cerclage may predict preterm delivery.

    Science.gov (United States)

    Behrens, O; Böhmer, S; Goeschen, K; Fuchs, A R

    1991-06-01

    Plasma oxytocin and prostaglandin F2 alpha metabolite (PGFM) concentrations were measured in 45 patients admitted for cerclage during the second trimester. Samples were collected before, 3 hours after, and 3 days after the Shirodkar procedure. Uterine activity was recorded by external tocography twice daily for 30 minutes. Twenty-eight women with uncomplicated pregnancy and commensurate gestational age served as controls. Cervical length, measured by ultrasonography, was significantly shorter before cerclage (36 +/- 2 mm) than after cerclage (43 +/- 2 mm) or compared with controls (48 +/- 1 mm). Bishop scores ranged from 3-6 (median 4) in the cerclage group and 0-1 (median 0) in controls. Fifteen cerclage patients and one control delivered preterm 5-22 weeks after the procedure. Initial plasma PGFM levels were significantly higher in cerclage patients than in controls. The cerclage procedure caused an immediate rise in plasma PGFM and a subsequent fall below initial levels to control values. Neither the initial levels of PGFM nor the increments 3 hours after cerclage correlated with the outcome of pregnancy. By contrast, plasma oxytocin levels before cerclage were significantly higher in patients who subsequently delivered preterm than in those who delivered at term. Cerclage resulted in a significant fall in plasma oxytocin at 3 hours in patients with preterm delivery, but after 3 days the oxytocin levels had returned to the precerclage values. Patients who had increased uterine contractions had significantly higher plasma oxytocin levels but lower PGFM levels than those without contractions.(ABSTRACT TRUNCATED AT 250 WORDS)

  6. Data-driven, Interpretable Photometric Redshifts Trained on Heterogeneous and Unrepresentative Data

    Science.gov (United States)

    Leistedt, Boris; Hogg, David W.

    2017-03-01

    We present a new method for inferring photometric redshifts in deep galaxy and quasar surveys, based on a data-driven model of latent spectral energy distributions (SEDs) and a physical model of photometric fluxes as a function of redshift. This conceptually novel approach combines the advantages of both machine learning methods and template fitting methods by building template SEDs directly from the spectroscopic training data. This is made computationally tractable with Gaussian processes operating in flux–redshift space, encoding the physics of redshifts and the projection of galaxy SEDs onto photometric bandpasses. This method alleviates the need to acquire representative training data or to construct detailed galaxy SED models; it requires only that the photometric bandpasses and calibrations be known or have parameterized unknowns. The training data can consist of a combination of spectroscopic and deep many-band photometric data with reliable redshifts, which do not need to entirely spatially overlap with the target survey of interest or even involve the same photometric bands. We showcase the method on the i-magnitude-selected, spectroscopically confirmed galaxies in the COSMOS field. The model is trained on the deepest bands (from SUBARU and HST) and photometric redshifts are derived using the shallower SDSS optical bands only. We demonstrate that we obtain accurate redshift point estimates and probability distributions despite the training and target sets having very different redshift distributions, noise properties, and even photometric bands. Our model can also be used to predict missing photometric fluxes or to simulate populations of galaxies with realistic fluxes and redshifts, for example.

  7. Moderate resolution spectrophotometry of high redshift quasars

    Science.gov (United States)

    Schneider, Donald P.; Schmidt, Maarten; Gunn, James E.

    1991-01-01

    A uniform set of photometry and high signal-to-noise moderate resolution spectroscopy of 33 quasars with redshifts larger than 3.1 is presented. The sample consists of 17 newly discovered quasars (two with redshifts in excess of 4.4) and 16 sources drawn from the literature. The objects in this sample have r magnitudes between 17.4 and 21.4; their luminosities range from -28.8 to -24.9. Three of the 33 objects are broad absorption line quasars. A number of possible high redshift damped Ly-alpha systems were found.

  8. Lensing convergence in galaxy redshift surveys

    CERN Document Server

    Cardona, Wilmar; Kunz, Martin; Montanari, Francesco

    2016-01-01

    In this letter we demonstrate the importance of including the lensing contribution in galaxy clustering analyses with large galaxy redshift surveys. It is well known that radial cross-correlations between different redshift bins of galaxy surveys are dominated by lensing. But we show here that also neglecting lensing in the auto-correlations within one bin severely biases cosmological parameter estimation with redshift surveys. It leads to significant shifts for several cosmological parameters, most notably the scalar amplitude, the scalar spectral index and in particular the neutrino mass scale. Especially the latter parameter is one of the main targets of future galaxy surveys.

  9. The New Redshift Interpretation Affirmed

    CERN Document Server

    Gentry, R V

    1998-01-01

    In late 1997 I reported (Mod. Phys. Lett. A 12 (1997) 2919; astro-ph/9806280) the discovery of A New Redshift Interpretation (NRI) of the Hubble relation and the 2.7K CBR, which showed for the first time that it was possible to explain these phenomena within the framework of a universe governed by Einstein's static-spacetime general relativity (GR) instead of the Friedmann-Lemaitre expanding-spacetime paradigm. More recently Carlip and Scranton (astro-ph/9808021; C&S) claim to find flaws in this discovery, while also claiming the standard cosmology is error free. Their analysis assumes the NRI represents a static cosmological model of the universe. This is wrong. My MPLA report clearly states the NRI encompasses an expanding universe wherein galaxies are undergoing Doppler recession due to vacuum density repulsion. C&S's confusion on this crucial point leads to serious errors in their analysis. Next, in claiming the standard cosmology is error free, C&S fail to respond to the contradictory evidenc...

  10. Molecular Gas at High Redshift

    CERN Document Server

    Solomon, P M

    2005-01-01

    The Early Universe Molecular Emission Line Galaxies (EMGs) are a population of galaxies with only 36 examples that hold great promise for the study of galaxy formation and evolution at high redshift. The classification, luminosity of molecular line emission, molecular mass, far-infrared (FIR) luminosity, star formation efficiency, morphology, and dynamical mass of the currently known sample are presented and discussed. The star formation rates derived from the FIR luminosity range from about 300 to 5000 M(sun)per year and the molecular mass from 4 x 10^9 to 1 x 10^{11} M(sun). At the lower end, these star formation rates, gas masses, and diameters are similar to those of local ultraluminous infrared galaxies, and represent starbursts in centrally concentrated disks, sometimes, but not always, associated with active galactic nuclei. The evidence for large (> 5 kpc) molecular disks is limited. Morphology and several high angular resolution images suggest that some EMGs are mergers with a massive molecular inter...

  11. Redshift Factor and the First Law of Binary Black Hole Mechanics in Numerical Simulations.

    Science.gov (United States)

    Zimmerman, Aaron; Lewis, Adam G M; Pfeiffer, Harald P

    2016-11-04

    The redshift factor z is an invariant quantity of fundamental interest in post-Newtonian and self-force descriptions of compact binaries. It connects different approximation schemes, and plays a central role in the first law of binary black hole mechanics, which links local quantities to asymptotic measures of energy and angular momentum in these systems. Through this law, the redshift factor is conjectured to have a close relation to the surface gravity of the event horizons of black holes in circular orbits. We propose and implement a novel method for extracting the redshift factor on apparent horizons in numerical simulations of quasicircular binary inspirals. Our results confirm the conjectured relationship between z and the surface gravity of the holes and that the first law holds to a remarkable degree for binary inspirals. The redshift factor enables tests of analytic predictions for z in spacetimes where the binary is only approximately circular, giving a new connection between analytic approximations and numerical simulations.

  12. The redshift factor and the first law of binary black hole mechanics in numerical simulations

    CERN Document Server

    Zimmerman, Aaron; Pfeiffer, Harald P

    2016-01-01

    The redshift factor $z$ is an invariant quantity of fundamental interest in Post-Newtonian and self-force descriptions of compact binaries. It connects different approximation schemes, and plays a central role in the first law of binary black hole mechanics, which links local quantities to asymptotic measures of energy and angular momentum in these systems. Through this law, the redshift factor is conjectured to have a close relation to the surface gravity of the event horizons of black holes in circular orbits. We propose and implement a novel method for extracting the redshift factor on apparent horizons in numerical simulations of quasi-circular binary inspirals. Our results confirm the conjectured relationship between $z$ and the surface gravity of the holes and that the first law holds to a remarkable degree for binary inspirals. The redshift factor allows us to test analytic predictions for $z$ in spacetimes where the binary is only approximately circular, giving a new connection between analytic approx...

  13. Plasma proteomics classifiers improve risk prediction for renal disease in patients with hypertension or type 2 diabetes

    DEFF Research Database (Denmark)

    Pena, Michelle J; Jankowski, Joachim; Heinze, Georg

    2015-01-01

    OBJECTIVE: Micro and macroalbuminuria are strong risk factors for progression of nephropathy in patients with hypertension or type 2 diabetes. Early detection of progression to micro and macroalbuminuria may facilitate prevention and treatment of renal diseases. We aimed to develop plasma...... proteomics classifiers to predict the development of micro or macroalbuminuria in hypertension or type 2 diabetes. METHODS: Patients with hypertension (n = 125) and type 2 diabetes (n = 82) were selected for this case-control study from the Prevention of REnal and Vascular ENd-stage Disease cohort....... RESULTS: In hypertensive patients, the classifier improved risk prediction for transition in albuminuria stage on top of the reference model (C-index from 0.69 to 0.78; P diabetes, the classifier improved risk prediction for transition from micro to macroalbuminuria (C-index from 0...

  14. Plasma osmolality predicts mortality in patients with heart failure with reduced ejection fraction.

    Science.gov (United States)

    Kaya, HakkI; Yücel, Oğuzhan; Ege, Meltem Refiker; Zorlu, Ali; Yücel, Hasan; Güneş, Hakan; Ekmekçi, Ahmet; Yılmaz, Mehmet Birhan

    2017-01-01

    Heart failure (HF) is a fatal disease. Plasma osmolality with individual impacts of sodium, blood urea nitrogen (BUN), and glucose has not been studied prognostically in patients with HF. This study aims to investigate the impact of serum osmolality on clinical endpoints in HF patients. A total of 509 patients (383 males, 126 females) with HF with reduced ejection fraction in three HF centres were retrospectively analysed between January 2007 and December 2013. Follow-up data were completed for 496 patients. Plasma osmolality was calculated as (2 × Na) + (BUN/2.8) + (Glucose/18). Quartiles of plasma osmolality were produced, and the possible relationship between plasma osmolality and cardiovascular mortality was investigated. The mean follow-up was 25 ± 22 months. The mean age was 56.5 ± 17.3 years with a mean EF of 26 ± 8%. The mean levels of plasma osmolality were as follows in the quartiles: 1st % = 280 ± 6, 2nd % = 288 ± 1, 3rd % = 293 ± 2 (95% confidence interval [CI] 292.72-293.3), and 4th % = 301 ± 5 mOsm/kg. The EF and B-type natriuretic peptide levels were similar in the four quartiles. Univariate and multivariate analyses in the Cox proportional hazard model revealed a significantly higher rate of mortality in the patients with hypo-osmolality. The Kaplan-Meier plot showed graded mortality curves with the 1st quartile having the worst prognosis, followed by the 4th quartile and the 2nd quartile, while the 3rd quartile was shown to have the best prognosis. Our study results suggest that normal plasma osmolality is between 275 and 295 mOsm/kg. However, being close to the upper limit of normal range (292-293 mOsm/kg) seems to be the optimal plasma osmolality level in terms of cardiovascular prognosis in patients with HF.

  15. Plasma Soluble CD163 Level Independently Predicts All-Cause Mortality in HIV-1-Infected Individuals.

    Science.gov (United States)

    Knudsen, Troels Bygum; Ertner, Gideon; Petersen, Janne; Møller, Holger Jon; Moestrup, Søren K; Eugen-Olsen, Jesper; Kronborg, Gitte; Benfield, Thomas

    2016-10-15

    CD163, a monocyte- and macrophage-specific scavenger receptor, is shed as soluble CD163 (sCD163) during the proinflammatory response. Here, we assessed the association between plasma sCD163 levels and progression to AIDS and all-cause mortality among individuals infected with human immunodeficiency virus type 1 (HIV). Plasma sCD163 levels were measured in 933 HIV-infected individuals. Hazard ratios (HRs) with 95% confidence intervals (CIs) associated with mortality were computed by Cox proportional hazards regression. At baseline, 86% were receiving antiretroviral treatment, 73% had plasma a HIV RNA level of Plasma sCD163 levels were higher in nonsurvivors than in survivors (4.92 mg/L [interquartile range {IQR}, 3.29-8.65 mg/L] vs 3.16 mg/L [IQR, 2.16-4.64 mg/L]; P = .0001). The cumulative incidence of death increased with increasing plasma sCD163 levels, corresponding to a 6% or 35% increased risk of death for each milligram per liter or quartile increase, respectively, in baseline plasma sCD163 level (adjusted HR, 1.06 [95% CI, 1.03-1.09] and 1.35 [95% CI, 1.13-1.63], respectively). Plasma sCD163 was an independent marker of all-cause mortality in a cohort of HIV-infected individuals, suggesting that monocyte/macrophage activation may play a role in HIV pathogenesis and be a target of intervention. © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.

  16. Predictive Value of Nuclear Factor κB Activity and Plasma Cytokine Levels in Patients with Sepsis

    Science.gov (United States)

    Arnalich, Francisco; Garcia-Palomero, Esther; López, Julia; Jiménez, Manuel; Madero, Rosario; Renart, Jaime; Vázquez, Juan José; Montiel, Carmen

    2000-01-01

    The relationship between fluctuating cytokine concentrations in plasma and the outcome of sepsis is complex. We postulated that early measurement of the activation of nuclear factor κB (NF-κB), a transcriptional regulatory protein involved in proinflammatory cytokine expression, may help to predict the outcome of sepsis. We determined NF-κB activation in peripheral blood mononuclear cells of 34 patients with severe sepsis (23 survivors and 11 nonsurvivors) and serial concentrations of inflammatory cytokines (interleukin-6, interleukin-1, and tumor necrosis factor) and various endogenous antagonists in plasma. NF-κB activity was significantly higher in nonsurvivors and correlated strongly with the severity of illness (APACHE II score), although neither was related to the cytokine levels. Apart from NF-κB activity, the interleukin-1 receptor antagonist was the only cytokine tested whose level in plasma was of value in predicting mortality by logistic regression analysis. These results underscore the prognostic value of early measurement of NF-κB activity in patients with severe sepsis. PMID:10722586

  17. Photometric redshifts and selection of high redshift galaxies in the NTT and Hubble Deep Fields

    CERN Document Server

    Fontana, A; Poli, F; Giallongo, E; Arnouts, S; Cristiani, S; Moorwood, A F M; Saracco, P

    2000-01-01

    We present and compare in this paper new photometric redshift catalogs of the galaxies in three public fields: the NTT Deep Field, the HDF-N and the HDF-S. Photometric redshifts have been obtained for thewhole sample, by adopting a $\\chi^2$ minimization technique on a spectral library drawn from the Bruzual and Charlot synthesis models, with the addition of dust and intergalactic absorption. The accuracy, determined from 125 galaxies with known spectroscopic redshifts, is $\\sigma_z\\sim 0.08 (0.3)$ in the redshift intervals $z=0-1.5 (1.5-3.5)$. The global redshift distribution of I-selected galaxies shows a distinct peak at intermediate redshifts, z~0.6 at I_{AB}5 candidates in the HDF filter set and that the 4 brightest candidates at $z>5$ in the HDF-S are indeed most likely M stars. (ABRIDGED)

  18. Color-redshift Relations and Photometric Redshift Estimations of Quasars in Large Sky Surveys

    CERN Document Server

    Wu, X B; Zhou, X; Wu, Xue-Bing; Zhang, Wei; Zhou, Xu

    2004-01-01

    With a recently constructed composite quasar spectrum and the \\chi^2 minimization technique, we demonstrated a general method to estimate the photometric redshifts of a large sample of quasars by deriving the theoretical color-redshift relations and comparing the theoretical colors with the observed ones. We estimated the photometric redshifts from the 5-band SDSS photometric data of 18678 quasars in the first major data release of SDSS and compare them with the spectroscopic redshifts. The redshift difference is smaller than 0.1 for 47% of quasars and 0.2 for 68 % of them. Based on the calculation of the theoretical color-color diagrams of stars, galaxies and quasars in both the SDSS and BATC photometric systems, we expected that with the BATC system of 15 intermediate filters we would be able to select candidates of high redshift quasars more efficiently than in the SDSS, provided the BATC survey could detect objects with magnitude fainter than 21.

  19. Prediction of the cathodic arc root behaviour in a hollow cathode thermal plasma torch

    Energy Technology Data Exchange (ETDEWEB)

    Freton, Pierre; Gonzalez, Jean-Jacques; Escalier, Gaelle, E-mail: pierre.freton@laplace.univ-tlse.f [Universite de Toulouse, UPS, INPT, LAPLACE (Laboratoire Plasma et Conversion d' Energie), 118 route de Narbonne, F-31062 Toulouse cedex 9 (France)

    2009-10-07

    The upper part of a well type cathode (WTC) plasma torch is modelled for several conditions in an air medium in the presence of an electric arc. The plasma flow created by the electric arc is described and the results compared with the data from the literature. Special attention is paid to the description of arc root attachment and to its movement due to the balance of forces. A fine description of the magnetic field produced by the external solenoid is reported. The model is based on the Fluent software implemented with specific developments to be adapted to the thermal plasma domain. The paper shows the necessity to provide an accurate description of the external magnetic field due to the strong influence of the radial magnetic field component. Overall, we propose an original approach for arc root movement description which contributes to the understanding of the flow behaviour in the WTC torch.

  20. Plasma Soluble CD163 Level Independently Predicts All-Cause Mortality in HIV-1-Infected Individuals

    DEFF Research Database (Denmark)

    Knudsen, Troels Bygum; Ertner, Gideon; Petersen, Janne

    2016-01-01

    Background: CD163, a monocyte- and macrophage-specific scavenger receptor, is shed as soluble CD163 (sCD163) during the proinflammatory response. Here, we assessed the association between plasma sCD163 levels and progression to AIDS and all-cause mortality among individuals infected with human...... immunodeficiency virus type 1 (HIV). Methods: Plasma sCD163 levels were measured in 933 HIV–infected individuals. Hazard ratios (HRs) with 95% confidence intervals (CIs) associated with mortality were computed by Cox proportional hazards regression. Results: At baseline, 86% were receiving antiretroviral treatment......, 73% had plasma a HIV RNA level of CD163 levels were higher in nonsurvivors than in survivors (4.92 mg/L [interquartile range {IQR}, 3.29–8.65 mg/L] vs 3.16 mg/L [IQR, 2...

  1. Plasma Soluble CD163 Level Independently Predicts All-Cause Mortality in HIV-1-Infected Individuals

    DEFF Research Database (Denmark)

    Knudsen, Troels Bygum; Ertner, Gideon; Petersen, Janne

    2016-01-01

    BACKGROUND: CD163, a monocyte- and macrophage-specific scavenger receptor, is shed as soluble CD163 (sCD163) during the proinflammatory response. Here, we assessed the association between plasma sCD163 levels and progression to AIDS and all-cause mortality among individuals infected with human...... immunodeficiency virus type 1 (HIV). METHODS: Plasma sCD163 levels were measured in 933 HIV-infected individuals. Hazard ratios (HRs) with 95% confidence intervals (CIs) associated with mortality were computed by Cox proportional hazards regression. RESULTS: At baseline, 86% were receiving antiretroviral treatment......, 73% had plasma a HIV RNA level of CD163 levels were higher in nonsurvivors than in survivors (4.92 mg/L [interquartile range {IQR}, 3.29-8.65 mg/L] vs 3.16 mg/L [IQR, 2...

  2. Decoding quasars: gravitationally redshifted spectral lines !

    CERN Document Server

    Kantharia, Nimisha G

    2016-01-01

    Further investigation of data on quasars, especially in the ultraviolet band, yields an amazingly coherent narrative which we present in this paper. Quasars are characterised by strong continuum emission and redshifted emission and absorption lines which includes the famous Lyman $\\alpha$ forest. We present irrefutable evidence in support of (1) the entire line spectrum arising in matter located inside the quasar system, (2) the range of redshifts shown by the lines being due to the variable contribution of the gravitational redshift in the observed line velocity, (3) existence of rotating black holes and of matter inside its ergosphere, (4) quasars located within cosmological redshifts $\\sim 3$, (5) $\\gamma$ ray bursts being explosive events in a quasar. These results are significant and a game-changer when we realise that the absorbing gas has been postulated to exist along the line-of-sight to the quasar and observations have accordingly been interpreted. In light of these definitive results which uniquely...

  3. Giving Cosmic Redshift Drift a Whirl

    CERN Document Server

    Kim, Alex G; Edelstein, Jerry; Erskine, David

    2014-01-01

    Redshift drift provides a direct kinematic measurement of cosmic acceleration but it occurs with a characteristic time scale of a Hubble time. Thus redshift observations with a challenging precision of $10^{-9}$ require a 10 year time span to obtain a signal-to-noise of 1. We discuss theoretical and experimental approaches to address this challenge, potentially requiring less observer time and having greater immunity to common systematics. On the theoretical side we explore allowing the universe, rather than the observer, to provide long time spans; speculative methods include radial baryon acoustic oscillations, cosmic pulsars, and strongly lensed quasars. On the experimental side, we explore beating down the redshift precision using differential interferometric techniques, including externally dispersed interferometers and spatial heterodyne spectroscopy. Low-redshift emission line galaxies are identified as having high cosmology leverage and systematics control, with an 8 hour exposure on a 10-meter telesc...

  4. The plasma level of soluble urokinase receptor is elevated in patients with Streptococcus pneumoniae bacteraemia and predicts mortality

    DEFF Research Database (Denmark)

    Wittenhagen, P; Kronborg, G; Weis, N;

    2004-01-01

    This multicentre prospective study was conducted to investigate whether the level of the soluble form of urokinase-type plasminogen activator receptor (suPAR) is elevated during pneumococcal bacteraemia and is of predictive value in the early stage of the disease. Plasma levels of suPAR were...... (n = 117; p cerebral symptoms and high serum concentrations of protein YKL-40 and suPAR were associated significantly with mortality (p ....05). In multivariate analysis, only suPAR remained a significant predictor of death (mortality rate of 13 for suPAR levels of > 10 ng/mL; 95% CI: 1.1-158). The increase in suPAR levels may reflect increased expression by vascular or inflammatory cells in the setting of pneumococcal sepsis. This plasma protein may...

  5. HbA1c, fasting plasma glucose and the prediction of diabetes

    DEFF Research Database (Denmark)

    Soulimane, Soraya; Simon, Dominique; Shaw, Jonathan

    2012-01-01

    With diabetes defined by HbA1c≥6.5% and/or FPG≥7.0mmol/l and/or diabetes treatment, we investigated HbA1c and fasting plasma glucose (FPG) thresholds/change-points above which the incidence of diabetes increases.......With diabetes defined by HbA1c≥6.5% and/or FPG≥7.0mmol/l and/or diabetes treatment, we investigated HbA1c and fasting plasma glucose (FPG) thresholds/change-points above which the incidence of diabetes increases....

  6. Prediction of Dissociation Process of Ceramic Powder Materials under Plasma Heating Conditions

    Institute of Scientific and Technical Information of China (English)

    WangBoyi; TianWendong

    1993-01-01

    A model of the thermal dissocition process has been developed for the numerical simulation of ceramic powder processing in a d.c. plasma reactor.The temperature histories of zircon grains were calculated based on this model.Comparisons were carried out to determine the effects of plasma gas (N2 and Ar),free stream temperature (6000-15000)K and Reynolds number (0.0-1.0) as well as particle diameter(20-200μm)on the zircon dissociation process.The influences of proper Nusselt numer correlation and variable transport properties were discussed in detail.

  7. HbA1c, fasting plasma glucose and the prediction of diabetes

    DEFF Research Database (Denmark)

    Soulimane, Soraya; Simon, Dominique; Shaw, Jonathan

    2012-01-01

    With diabetes defined by HbA1c≥6.5% and/or FPG≥7.0mmol/l and/or diabetes treatment, we investigated HbA1c and fasting plasma glucose (FPG) thresholds/change-points above which the incidence of diabetes increases.......With diabetes defined by HbA1c≥6.5% and/or FPG≥7.0mmol/l and/or diabetes treatment, we investigated HbA1c and fasting plasma glucose (FPG) thresholds/change-points above which the incidence of diabetes increases....

  8. Distribution of streaming rates into high-redshift galaxies

    CERN Document Server

    Goerdt, Tobias; Dekel, Avishai; Teyssier, Romain

    2015-01-01

    We study the accretion along streams from the cosmic web into high-redshift massive galaxies using three sets of AMR hydro-cosmological simulations. We find that the streams keep a roughly constant accretion rate as they penetrate into the halo centre. The mean accretion rate follows the mass and redshift dependence predicted for haloes by the EPS approximation, dM / dt is proportional to Mvir^{1.25} (1 + z)^{2.5}. The distribution of the accretion rates can well be described by a sum of two Gaussians, the primary corresponding to "smooth inflow" and the secondary to "mergers". The same functional form was already found for the distributions of specific star formation rates in observations. The mass fraction in the smooth component is 60 - 90 %, insensitive to redshift or halo mass. The simulations with strong feedback show clear signs of re-accretion due to recycling of galactic winds. The mean accretion rate for the mergers is a factor 2 - 3 larger than that of the smooth component. The standard deviation o...

  9. Non-Gaussian Minkowski functionals & extrema counts in redshift space

    CERN Document Server

    Codis, Sandrine; Pogosyan, Dmitry; Bernardeau, Francis; Matsubara, Takahiko

    2013-01-01

    In the context of upcoming large-scale structure surveys such as Euclid, it is of prime importance to quantify the effect of peculiar velocities on geometric probes. Hence the formalism to compute in redshift space the geometrical and topological one-point statistics of mildly non-Gaussian 2D and 3D cosmic fields is developed. Leveraging the partial isotropy of the target statistics, the Gram-Charlier expansion of the joint probability distribution of the field and its derivatives is reformulated in terms of the corresponding anisotropic variables. In particular, the cosmic non-linear evolution of the Minkowski functionals, together with the statistics of extrema are investigated in turn for 3D catalogues and 2D slabs. The amplitude of the non-Gaussian redshift distortion correction is estimated for these geometric probes. In 3D, gravitational perturbation theory is implemented in redshift space to predict the cosmic evolution of all relevant Gram-Charlier coefficients. Applications to the estimation of the c...

  10. The Assembly of Supermassive Black Holes at High Redshifts

    CERN Document Server

    Tanaka, Takamitsu

    2008-01-01

    The supermassive black holes (SMBHs) massive enough (>10^9 Msun) to power the bright redshift z=6 quasars observed in the Sloan Digital Sky Survey (SDSS) are thought to have assembled by mergers and/or accretion from less massive ``seed'' BHs. If the seeds are the 100 Msun remnant BHs of the first generation of stars, they must be in place well before redshift z=6, and must avoid being ejected from their parent proto-galaxies by the large (several 100 km/s) kicks they suffer from gravitational-radiation induced recoil during mergers with other BHs. We simulate the SMBH mass function at redshift z>6 using dark matter (DM) halo merger trees, coupled with a prescription for the halo occupation fraction, accretion histories, and radial recoil trajectories of the growing BHs. Our purpose is (i) to map out plausible scenarios for successful assembly of the z=6 quasar BHs by exploring a wide region of parameter space, and (ii) to predict the rate of low-frequency gravitational wave events detectable by the Laser Int...

  11. Protoclusters Traced by High-Redshift Massive Galaxies

    Science.gov (United States)

    Garcia-Vergara, C.

    2017-08-01

    A commonly adopted approach to detect protoclusters is to search for overdensities of galaxies around massive galaxies at high-redshift such as quasars (QSOs) and submillimeter galaxies (SMGs). However, the detection of overdensities in those environments has been elusive, against of theoretical predictions. Here, I present the first measurement of the QSO-LBG and QSO-LAE cross-correlation function at z 4, based in the study of 23 QSO fields. My results indicate that LBG are strongly clustered around QSOs but LAE show similar clustering properties and number density as that observed in blank fields. One possible explanation for the lack of overdensities is that galaxies are highly obscured by dust and thus invisible at optical wavelengths. Additionally, I will present the clustering of SMGs based on spectroscopic redshift information of 52 SMGs recently identified by ALMA. This is critical to test if SMGs trace particularly massive structures. Finally, I will discuss the implications and interpretation of my results, in particular, I give the reasons of why I strongly suggest that the study of high-redshift protoclusters should be done from a combined optical+radio perspective.

  12. Optimal multihump filter for photometric redshifts

    OpenAIRE

    Budavari, Tamas; Szalay, Alexander S.; Csabai, Istvan; Connolly, Andrew J.; Tsvetanov, Zlatan

    2001-01-01

    We propose a novel type filter for multicolor imaging to improve on the photometric redshift estimation of galaxies. An extra filter - specific to a certain photometric system - may be utilized with high efficiency. We present a case study of the Hubble Space Telescope's Advanced Camera for Surveys and show that one extra exposure could cut down the mean square error on photometric redshifts by 34% over the z

  13. Uncertain Photometric Redshifts with Deep Learning Methods

    Science.gov (United States)

    D'Isanto, A.

    2017-06-01

    The need for accurate photometric redshifts estimation is a topic that has fundamental importance in Astronomy, due to the necessity of efficiently obtaining redshift information without the need of spectroscopic analysis. We propose a method for determining accurate multi-modal photo-z probability density functions (PDFs) using Mixture Density Networks (MDN) and Deep Convolutional Networks (DCN). A comparison with a Random Forest (RF) is performed.

  14. Leveraging 3D-HST Grism Redshifts to Quantify Photometric Redshift Performance

    CERN Document Server

    Bezanson, Rachel; Brammer, Gabriel B; van Dokkum, Pieter G; Franx, Marijn; Labbé, Ivo; Leja, Joel; Momcheva, Ivelina G; Nelson, Erica J; Quadri, Ryan F; Skelton, Rosalind E; Weiner, Benjamin J; Whitaker, Katherine E

    2015-01-01

    We present a study of photometric redshift accuracy in the 3D-HST photometric catalogs, using 3D-HST grism redshifts to quantify and dissect trends in redshift accuracy for galaxies brighter than $H_{F140W} 2$), dusty star-forming galaxies for which the scatter increases to $\\sim0.1(1+z)$. Although the overall photometric redshift accuracy for quiescent galaxies is better than for star-forming galaxies, scatter depends more strongly on magnitude and redshift than on galaxy type. We verify these trends using the redshift distributions of close pairs and extend the analysis to fainter objects, where photometric redshift errors further increase to $\\sim0.046(1+z)$ at $H_{F160W}=26$. We demonstrate that photometric redshift accuracy is strongly filter-dependent and quantify the contribution of multiple filter combinations. We evaluate the widths of redshift probability distribution functions and find that error estimates are underestimated by a factor of $\\sim1.1-1.6$, but that uniformly broadening the distributi...

  15. The Plasma Depletion Layer Beyond the Heliopause: Evidence, Implications, and Predictions for Voyager 2 and New Horizons

    Science.gov (United States)

    Cairns, Iver H.; Fuselier, S. A.

    2017-01-01

    A plasma depletion layer (PDL) is predicted beyond the heliopause, analogous to the PDLs observed sunwards of planetary magnetopauses: draping of interstellar medium (ISM) magnetic field lines over the heliopause should increase the magnetic field strength and, perpendicular ion temperature, cause density depletions by allowing plasma ions (and electrons) with large parallel temperatures to escape along {\\boldsymbol{B}}, and increase the temperature anisotropy until limited by wave instabilities. Published Voyager 1 magnetometer and plasma wave data provide strong evidence for the coupled magnetic amplification (≈ 30 % ) and density depletion (≈ 50 % ) expected for a weak PDL. The predicted reduction in parallel temperature is ≈ 50 % . The locations on the sky of the PDL and the points on the heliopause of maximum magnetic draping and total pressure are predicted using the ISM magnetic field direction obtained from the Interstellar Boundary Explorer (IBEX) ribbon. The IBEX ribbon overlies the former, as expected, while the latter lies within the ridge of maximum, non-ribbon, globally distributed flux. The PDL should be strongest along the ISM field line passing through these points and the Sun–ISM velocity vector. Based on their trajectories, Voyager 2 and New Horizons should observe a much stronger PDL (stronger magnetic amplification, density depletion, and changes in temperature) than Voyager 1. Finally, the reduced cosmic ray fluxes observed near 90° pitchangle by Voyager 1 beyond the heliopause appear qualitatively consistent with wave–particle interactions transferring perpendicular particle energy to parallel energy where the PDL is strong, followed by magnetic focusing as particles propagate into weaker magnetic field regions.

  16. Plasma copeptin levels and prediction of outcome in heart failure outpatients

    DEFF Research Database (Denmark)

    Balling, Louise; Kistorp, Caroline; Schou, Morten

    2012-01-01

    Copeptin, a stable fragment of the vasopressin prohormone, has been shown to be a significant biomarker for morbidity and mortality in heart failure. The aims of this study were to evaluate the influence of plasma sodium on the prognostic significance of copeptin concentrations in heart failure...

  17. A physiologically based kinetic model for the prediction of plasma cholesterol concentrations in mice and man

    NARCIS (Netherlands)

    Pas, van de N.

    2011-01-01

    An increased plasma cholesterol concentration is associated with increased risk of cardiovascular disease. However, individuals vary largely in their response to cholesterol lowering drugs and 40% of them, do not reach their cholesterol-lowering target. Development of novel therapies, for example co

  18. Perioperative plasma concentrations of stable nitric oxide products are predictive of cognitive dysfunction after laparoscopic cholecystectomy.

    LENUS (Irish Health Repository)

    Iohom, G

    2012-02-03

    In this study our objectives were to determine the incidence of postoperative cognitive dysfunction (POCD) after laparoscopic cholecystectomy under sevoflurane anesthesia in patients aged >40 and <85 yr and to examine the associations between plasma concentrations of i) S-100beta protein and ii) stable nitric oxide (NO) products and POCD in this clinical setting. Neuropsychological tests were performed on 42 ASA physical status I-II patients the day before, and 4 days and 6 wk after surgery. Patient spouses (n = 13) were studied as controls. Cognitive dysfunction was defined as deficit in one or more cognitive domain(s). Serial measurements of serum concentrations of S-100beta protein and plasma concentrations of stable NO products (nitrate\\/nitrite, NOx) were performed perioperatively. Four days after surgery, new cognitive deficit was present in 16 (40%) patients and in 1 (7%) control subject (P = 0.01). Six weeks postoperatively, new cognitive deficit was present in 21 (53%) patients and 3 (23%) control subjects (P = 0.03). Compared with the "no deficit" group, patients who demonstrated a new cognitive deficit 4 days postoperatively had larger plasma NOx at each perioperative time point (P < 0.05 for each time point). Serum S-100beta protein concentrations were similar in the 2 groups. In conclusion, preoperative (and postoperative) plasma concentrations of stable NO products (but not S-100beta) are associated with early POCD. The former represents a potential biochemical predictor of POCD.

  19. Dst prediction for a period of high-density plasmas in magnetic clouds

    Science.gov (United States)

    Adachi, H.; Sakurai, T.

    We examine geomagnetic effects for high-density plasmas in magnetic clouds and their relationship to solar sources. It is well known that Bz component of interplanetary magnetic field plays an important role for estimation of Dst from solar wind parameters (Burton et al.1975). However, magnetic clouds frequently carry high-density plasmas, which are interpreted as the remnants of filament. In order to clarify their geomagnetic effects, we try to estimate Dst by adopting different methods introducing effects of solar wind parameters. In our estimation the most important point is laid on the sense of Dst variation rather than its magnitude. The most suitable estimation is obtained by setting up a threshold for plasma density, in which for a case of plasma density greater than 20 /cc the Fenrich and Luhmann (1998)'s formula should be used, while in the other cases the Burton's formula are adopted. In both estimations the O'Brien and McPherron (2000)'s ring current decay time is employed. Furthermore, we examine the solar origin corresponding to the magnetic clouds and then compared characteristic signatures of the magnetic cloud with those observed on the solar surface. As a result, we confirm that the magnetic structure of interplanetary flux rope is in good agreement with the structures of the magnetic neutral line near disappearing filaments and heliospheric current sheet (HCS). On the basis of these studies, we suggest that for the geomagnetic disturbance forecast, the effect of high-density plasmas carried with magnetic clouds should be taken into account of as well as that of interplanetary magnetic field.

  20. Application of Response Surface Methodolody to Prediction of Dilution in Plasma Transferred Arc Hardfacing of Stainless Steel on Carbon Steel

    Institute of Scientific and Technical Information of China (English)

    V Balasubramanian; A K Lakshminarayanan; R Varahamoorthy; S Babu

    2009-01-01

    The application of.response surface methodology was highlighted to predict and optimize the percentage of dilution of iron-based hardfaced surface produced by the PTA (plasma transferred arc welding) process.The experiments were conducted based on five-factor five-level central composite rotatable design with full replication technique and a mathematical model was developed using response surface methodology.Furthermore,the response surface methodology was also used to optimize the process parameters that yielded the lowest percentage of dilution.

  1. Plasma pro-brain natriuretic peptide and electrocardiographic changes in combination improve risk prediction in persons without known heart disease

    DEFF Research Database (Denmark)

    Jørgensen, Peter G; Jensen, Jan S; Appleyard, Merete

    2015-01-01

    BACKGROUND: Though the electrocardiogram(ECG) and plasma pro-brain-natriuretic-peptide (pro-BNP) are widely used markers of subclinical cardiac injury and can be used to predict future cardiovascular disease(CVD), they could merely be markers of the same underlying pathology. We aimed to determine...... cohort study. Median follow-up was 10.4 years. High pro-BNP was defined as above 90th percentile of age and sex adjusted levels. The end-points were all-cause mortality and the combination of admission with ischemic heart disease, heart failure or CVD death. RESULTS: ECG changes were present in 907...

  2. Plasma concentration of asymmetric dimethylarginine (ADMA) predicts cardiovascular morbidity and mortality in type 1 diabetic patients with diabetic nephropathy

    DEFF Research Database (Denmark)

    Lajer, M.; Tarnow, L.; Jorsal, A.

    2008-01-01

    ), decline in GFR, ESRD, and all-cause mortality. RESULTS: Among patients with diabetic nephropathy, 37 patients (19.4%) with ADMA levels below the median, compared with 79 patients (43.4%) above the median, suffered a major cardiovascular event during the follow-up period (P ... after adjustment for conventional CVD risk factors including baseline GFR (adjusted hazard ratio [HR] for elevated ADMA 2.05 [95% CI 1.31-3.20], P = 0.002). Furthermore, elevated ADMA levels predicted an increased rate of decline in GFR, development of ESRD, and all-cause mortality (P ... adjustment for well-known progression promoters, including baseline GFR, the HR (adjusted) was 1.85 (95% CI 0.99-3.46, P = 0.055) for ESRD comparing upper and lower median ADMA levels. CONCLUSIONS: Plasma ADMA levels predict fatal and nonfatal cardiovascular events in patients with type 1 diabetic...

  3. Correlating structural order with structural rearrangement in dusty plasma liquids: can structural rearrangement be predicted by static structural information?

    Science.gov (United States)

    Su, Yen-Shuo; Liu, Yu-Hsuan; I, Lin

    2012-11-09

    Whether the static microstructural order information is strongly correlated with the subsequent structural rearrangement (SR) and their predicting power for SR are investigated experimentally in the quenched dusty plasma liquid with microheterogeneities. The poor local structural order is found to be a good alarm to identify the soft spot and predict the short term SR. For the site with good structural order, the persistent time for sustaining the structural memory until SR has a large mean value but a broad distribution. The deviation of the local structural order from that averaged over nearest neighbors serves as a good second alarm to further sort out the short time SR sites. It has the similar sorting power to that using the temporal fluctuation of the local structural order over a small time interval.

  4. Measuring and Modelling the Redshift Evolution of Clustering the Hubble Deep Field North

    CERN Document Server

    Arnouts, S; Moscardini, L; Matarrese, S; Lucchin, F; Fontana, A; Giallongo, E; Arnouts, Stephane; Cristiani, Stefano; Moscardini, Lauro; Matarrese, Sabino; Lucchin, Francesco; Fontana, Adriano; Giallongo, Emanuele

    1999-01-01

    (abridged) The evolution of galaxy clustering from z=0 to z=4.5 is analyzed using the angular correlation function and the photometric redshift distribution of galaxies brighter than I_{AB}\\le 28.5 in the HDF North. The reliability of the photometric redshift estimates is discussed on the basis of the available spectroscopic redshifts, comparing different codes and investigating the effects of photometric errors. The redshift bins in which the clustering properties are measured are then optimized to take into account the uncertainties of the photometric redshifts. The results show that the comoving correlation length has a small decrease in the range 0predictions of a variety of cosmological models belonging to the general class of CDM. The comparison with the expected mass clustering evolution indicates that the observed high-redshift galaxies are biased tracers of the dark matter with an effective bias b strongly i...

  5. Definitive Test of the R_h=ct Universe Using Redshift Drift

    CERN Document Server

    Melia, Fulvio

    2016-01-01

    The redshift drift of objects moving in the Hubble flow has been proposed as a powerful model-independent probe of the underlying cosmology. A measurement of the first and second order redshift derivatives appears to be well within the reach of upcoming surveys using ELT-HIRES and the SKA Phase 2 array. Here we show that an unambiguous prediction of the R_h=ct cosmology is zero drift at all redshifts, contrasting sharply with all other models in which the expansion rate is variable. For example, multi-year monitoring of sources at redshift z=5 with the ELT-HIRES is expected to show a velocity shift Delta v = -15 cm/s/yr due to the redshift drift in Planck LCDM, while Delta v=0 cm/s/yr in R_h=ct. With an anticipated ELT-HIRES measurement error of +/-5 cm/s/yr after 5 years, these upcoming redshift drift measurements might therefore be able to differentiate between R_h=ct and Planck LCDM at ~3 sigma, assuming that any possible source evolution is well understood. Such a result would provide the strongest eviden...

  6. Analytical Predictions of Field and Plasma Dynamics during Nonlinear Weibel-Mediated Flow Collisions

    Science.gov (United States)

    Ruyer, C.; Gremillet, L.; Bonnaud, G.; Riconda, C.

    2016-08-01

    The formation of collisionless shocks mediated by the ion Weibel instability is addressed theoretically and numerically in the nonrelativistic limit. First, the model developed in C. Ruyer et al., Phys. Plasmas 22, 032102 (2015) for the weakly nonlinear ion Weibel instability in a symmetric two-stream system is shown to be consistent with recent experimental and simulation results. Large-scale kinetic simulations are then performed to clarify the spatiotemporal evolution of the magnetic-field and plasma properties in the subsequent strongly nonlinear phase leading to shock formation. A simple analytical model is proposed which captures the simulation results up to a point close to ion isotropization. Electron screening effects are found important in the instability dynamics, so that numerical simulations using a nonphysical electron mass should be considered with caution.

  7. Cholesterol concentration in seminal plasma as a predictive tool for quality semen evaluation.

    Science.gov (United States)

    Beer-Ljubić, B; Aladrović, J; Marenjak, T S; Laskaj, R; Majić-Balić, I; Milinković-Tur, S

    2009-11-01

    The aim of this study was to investigate the relationship between lipid composition of bovine serum and seminal plasma, seasonality, and semen quality. The experiment was carried out in two groups of Simmental breeding bulls: Group I (ages 2 to 4 yr) and Group II (ages 5 to 10 yr). Blood samples were collected from jugular vein, and bovine semen was sampled with an artificial vagina once per season. Serum concentrations of total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triacylglycerols, nonesterified fatty acids (NEFAs), and lipoprotein electrophoretic patterns were determined. Seminal plasma concentrations of total cholesterol, HDL-C, and LDL-C were assayed. Serum concentration of triacylglycerols in young bulls was significantly higher in winter compared with that in autumn, whereas serum NEFA concentration was significantly higher in autumn compared with that in other seasons. Serum concentration of total cholesterol, LDL-C, and LDL lipoproteins in older bulls was significantly higher in winter than in spring. Seminal plasma concentration of total cholesterol in young bulls was significantly higher in spring compared with that in summer, whereas in older bulls it was significantly higher in winter compared with that in autumn samples. Sperm volume of both groups was significantly higher in summer compared with that in autumn and winter. Sperm motility in young bulls was lowest in summer and differed significantly from the values recorded in other seasons. The changes observed in seminal plasma cholesterol concentration were associated with extracellular lipid use and appeared to be applicable as a biochemical marker of sperm quality.

  8. Plasma osteopontin levels in prediction of prognosis in acute myocardial infarction.

    Science.gov (United States)

    Okyay, Kaan; Tavil, Yusuf; Sahinarslan, Asife; Tacoy, Gulten; Turfan, Murat; Sen, Nihat; Gurbahar, Ozlem; Boyaci, Bulent; Yalcin, Ridvan; Demirkan, Deniz; Cengel, Atiye

    2011-04-01

    We sought to explain the clinical importance of the osteopontin (OPN) in the setting of acute ST-elevation myocardial infarction (STEMI). Eighty consecutive patients (55 = 11 years, 12 women and 68 men) and sixty healthy control subjects were included in the study. In all patients, plasma OPN levels were assessed on admission and on the third day (peak value). Creatinine kinase (CK)/CK-myocardial band (MB), troponin I and N-terminal pro-brain natriuretic factor levels and echocardiographic findings were also recorded. Patients were classified into high and low OPN groups according to the median OPN value, and monitored for the occurrence of major adverse cardiovascular events (MACE). Patients with STEMI had higher OPN levels (23.8 [16.7-41.3] ng/ml) on admission than the control subjects (18.0 [11.3-31.5] ng/ml, P = 0.004).The third day value of OPN was significantly higher (39.2 [27.2-56.0] ng/ml) than the OPN level on admission (23.8 [16.7-41.3] ng/ml, P < 0.001). Admission and peak OPN levels were not correlated with CK/CK-MB, white blood cell counts, troponin I and the N-terminal pro-brain natriuretic factor. The plasma OPN levels were not correlated with left ventricular wall motion score index either. In the subgroups of infarct localization and reperfusion strategy, plasma OPN levels were similar. When the patients were compared according to the median OPN values, there were no differences in the occurrence of MACE between the high and low OPN groups. This study suggests, for the first time, that the plasma OPN level increases in the first hours of the acute STEMI; however, it could not be used as a prognostic biomarker of STEMI.

  9. Numerical Analysis of Microdischarge Oxygen Plasma and Prediction of Ozone Production Efficiency

    Science.gov (United States)

    Kawano, Satoyuki; Misaka, Takashi

    In this research, numerical simulation of oxygen plasma produced by dielectric barrier discharge (DBD) is made as a basic research for the application of bioprocesses such as sterilization. Numerical simulation is based on an appropriate modeling of microdischarges including 9 kinds of species and 54 chemical reactions. Behavior of the oxygen plasma is analyzed by finite difference method in two-dimensional computational region. The detailed characteristics of filamentous discharge formed between parallel dielectric surfaces which cover the electrodes are investigated. The qualitative tendency of the discharge formation process agrees with the previous experimental observation. Ozone production efficiency (OPE) is obtained and compared with experimental results. Dependency of reduced electric field E/n on OPE is investigated by comparing the numerical results with previous experimental results by other researcher, where E/n is the ratio of electric field EE to number density n of neutral molecule in the gas. It is confirmed that the present numerical simulation has practically enough accuracy for the evaluation of the OPE to optimize the oxygen plasma sterilization devices.

  10. The Subaru FMOS galaxy redshift survey (FastSound). IV. New constraint on gravity theory from redshift space distortions at $z\\sim 1.4$

    CERN Document Server

    Okumura, Teppei; Totani, Tomonori; Tonegawa, Motonari; Okada, Hiroyuki; Glazebrook, Karl; Blake, Chris; Ferreira, Pedro G; More, Surhud; Taruya, Atsushi; Tsujikawa, Shinji; Akiyama, Masayuki; Dalton, Gavin; Goto, Tomotsugu; Ishikawa, Takashi; Iwamuro, Fumihide; Matsubara, Takahiko; Nishimichi, Takahiro; Ohta, Kouji; Shimizu, Ikkoh; Takahashi, Ryuichi; Takato, Naruhisa; Tamura, Naoyuki; Yabe, Kiyoto; Yoshida, Naoki

    2015-01-01

    We measure the redshift-space correlation function from a spectroscopic sample of 2830 emission line galaxies from the FastSound survey. The survey, which uses the Subaru Telescope and covers the redshift ranges of $1.19redshifts. We detect clear anisotropy due to redshift-space distortions (RSD) both in the correlation function as a function of separations parallel and perpendicular to the line of sight and its quadrupole moment. RSD has been extensively used to test general relativity on cosmological scales at $z<1$. Adopting a LCDM cosmology, and using the RSD measurements on scales above 8Mpc/h, we obtain the first constraint on the growth rate at the redshift, $f(z)\\sigma_8(z)=0.482\\pm 0.116$ at $z\\sim 1.4$. This corresponds to $4.2\\sigma$ detection of RSD, after marginalizing over the galaxy bias parameter $b(z)\\sigma_8(z)$. Our constraint is consistent with the prediction of general relativity $f\\sigma_8\\sim 0.392$ within the $1-\\sigma$ co...

  11. Plasma levels of soluble HLA-E and HLA-F at diagnosis may predict overall survival of neuroblastoma patients.

    Science.gov (United States)

    Morandi, Fabio; Cangemi, Giuliana; Barco, Sebastiano; Amoroso, Loredana; Giuliano, Maria; Gigliotti, Anna Rita; Pistoia, Vito; Corrias, Maria Valeria

    2013-01-01

    The purpose of this study was to identify the plasma/serum biomarkers that are able to predict overall survival (OS) of neuroblastoma (NB) patients. Concentration of soluble (s) biomarkers was evaluated in plasma (sHLA-E, sHLA-F, chromogranin, and B7H3) or serum (calprotectin) samples from NB patients or healthy children. The levels of biomarkers that were significantly higher in NB patients were then analyzed considering localized or metastatic subsets. Finally, biomarkers that were significantly different in these two subsets were correlated with patient's outcome. With the exception of B7H3, levels of all molecules were significantly higher in NB patients than those in controls. However, only chromogranin, sHLA-E, and sHLA-F levels were different between patients with metastatic and localized tumors. sHLA-E and -F levels correlated with each other but not chromogranin. Chromogranin levels correlated with different event-free survival (EFS), whereas sHLA-E and -F levels also correlated with different OS. Association with OS was also detected considering only patients with metastatic disease. In conclusion, low levels of sHLA-E and -F significantly associated with worse EFS/OS in the whole cohort of NB patients and in patients with metastatic NB. Thus, these molecules deserve to be tested in prospective studies to evaluate their predictive power for high-risk NB patients.

  12. Plasma Levels of Soluble HLA-E and HLA-F at Diagnosis May Predict Overall Survival of Neuroblastoma Patients

    Directory of Open Access Journals (Sweden)

    Fabio Morandi

    2013-01-01

    Full Text Available The purpose of this study was to identify the plasma/serum biomarkers that are able to predict overall survival (OS of neuroblastoma (NB patients. Concentration of soluble (s biomarkers was evaluated in plasma (sHLA-E, sHLA-F, chromogranin, and B7H3 or serum (calprotectin samples from NB patients or healthy children. The levels of biomarkers that were significantly higher in NB patients were then analyzed considering localized or metastatic subsets. Finally, biomarkers that were significantly different in these two subsets were correlated with patient’s outcome. With the exception of B7H3, levels of all molecules were significantly higher in NB patients than those in controls. However, only chromogranin, sHLA-E, and sHLA-F levels were different between patients with metastatic and localized tumors. sHLA-E and -F levels correlated with each other but not chromogranin. Chromogranin levels correlated with different event-free survival (EFS, whereas sHLA-E and -F levels also correlated with different OS. Association with OS was also detected considering only patients with metastatic disease. In conclusion, low levels of sHLA-E and -F significantly associated with worse EFS/OS in the whole cohort of NB patients and in patients with metastatic NB. Thus, these molecules deserve to be tested in prospective studies to evaluate their predictive power for high-risk NB patients.

  13. Plasma Renin Activity Predicts Blood Pressure Responses to β-Blocker and Thiazide Diuretic as Monotherapy and Add-On Therapy for Hypertension

    Science.gov (United States)

    Turner, Stephen T.; Schwartz, Gary L.; Chapman, Arlene B.; Beitelshees, Amber L.; Gums, John G.; Cooper-DeHoff, Rhonda M.; Boerwinkle, Eric; Johnson, Julie A.; Bailey, Kent R.

    2010-01-01

    BACKGROUND Age and race categories or renin profiling have been recommended to predict blood pressure responses to monotherapy with a β-blocker or thiazide diuretic. Whether these or other characteristics predict blood pressure responses when the drugs are administered as add-on therapy is uncertain. METHODS We evaluated predictors of blood pressure response in 363 men and women ≤65 years of age with primary hypertension (152 blacks, 211 whites), 86 of whom (24%) were untreated and 277 of whom (76%) were withdrawn from previous antihypertensive drugs before randomization to either atenolol followed by addition of hydrochlorothiazide (N = 180) or hydrochlorothiazide followed by addition of atenolol (N = 183). Responses were determined by home blood pressure averages before and after each drug administration. Race, age, plasma renin activity, and other characteristics including pretreatment blood pressure levels were incorporated into linear regression models to quantify their contributions to prediction of blood pressure responses. RESULTS Plasma renin activity and pretreatment blood pressure level consistently contributed to prediction of systolic and diastolic responses to each drug administered as mono- and as add-on therapy. Higher plasma renin activity was consistently associated with greater blood pressure responses to atenolol and lesser responses to hydrochlorothiazide. The predictive effects of plasma renin activity were statistically independent of race, age, and other characteristics. CONCLUSIONS Plasma renin activity and pretreatment blood pressure level predict blood pressure responses to atenolol and hydrochlorothiazide administered as mono- and as add-on therapy in men and women ≤65 years of age. PMID:20725057

  14. Prediction of plasma caffeine concentrations in young adolescents following ingestion of caffeinated energy drinks: a Monte Carlo simulation.

    Science.gov (United States)

    Lee, Jung Woo; Kim, Yookyung; Perera, Vidya; McLachlan, Andrew J; Bae, Kyun-Seop

    2015-12-01

    The fast-growing consumption of caffeinated energy drinks (CEDs) is linked to increasing reports of caffeine intoxication in adolescents. There is limited data available regarding plasma caffeine concentrations in this population after CED intake and the potential implications for caffeine-related toxicity. This study was an in silico population pharmacokinetic analysis of caffeine. Population pharmacokinetic model of oral caffeine was derived from a previous study of healthy male volunteers. Maximal plasma caffeine concentration (C max) profiles following ingestion of one or two servings of popular CEDs were predicted using Monte Carlo simulation and available population body weight data of 10-15-year-old Korean adolescents. Caffeine C max values were positively correlated with the amount of caffeine ingested in CEDs and negatively correlated with body weight. The median (range) C max profiles varied from a low of 1.2 (0.5-2.6) mg/L to a concentration that is potentially associated with harmful caffeine-related effects of 25.4 (8.1-55.6) mg/L. A subgroup of female 10-11-year-old subjects exhibited the highest caffeine exposure profiles. These data indicate that CED ingestion can increase the risk of serious caffeine intoxication in young adolescents, particularly those with low body mass. • Excessive consumption of caffeine can lead to serious caffeine intoxication. • The risk of potential harmful caffeine intoxication after ingestion of caffeinated energy drinks (CED) has not been adequately evaluated in adolescents. • Predicted maximal plasma caffeine concentration profiles of adolescents with lower body weights showed an overlap with the ingested caffeine concentrations obtained from documented fatalities. • The present simulation-based pharmacokinetic analysis demonstrates that CED ingestion could lead to potentially serious caffeine intoxication in this cohort.

  15. Low plasma arginine:asymmetric dimethyl arginine ratios predict mortality after intracranial aneurysm rupture

    DEFF Research Database (Denmark)

    Staalsø, Jonatan Myrup; Bergström, Anita; Edsen, Troels

    2013-01-01

    Asymmetrical dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthases, predicts mortality in cardiovascular disease and has been linked to cerebral vasospasm after aneurysmal subarachnoid hemorrhage (SAH). In this prospective study, we assessed whether circulating ADMA, arginine...

  16. Color-Redshift Relations and Photometric Redshift Estimations of Quasars in Large Sky Surveys

    Institute of Scientific and Technical Information of China (English)

    Xue-Bing Wu; Wei Zhang; Xu Zhou

    2004-01-01

    With a recently constructed composite quasar spectrum and the χ2 minimization technique, we describe a general method for estimating the photometric redshifts of a large sample of quasars by deriving theoretical color-redshift relations and comparing the theoretical colors with the observed ones. We estimated the photometric redshifts from the 5-band SDSS photometric data of 18678 quasars in the first major data release of SDSS and compared them with their spectroscopic redshifts. The difference is less than 0.1 for 47% of the quasars and less than 0.2for 68%. Based on the calculation of the theoretical color-color diagrams of stars,galaxies and quasars both on the SDSS system and on the BATC system, we expect that we would be able to select candidates of high redshift quasars more efficaciously with the latter than with the former, provided the BATC survey can detect objects with magnitudes fainter than 21.

  17. Photometric redshifts in the SWIRE Survey

    CERN Document Server

    Rowan-Robinson, Michael; Oliver, Seb; Trichas, Markos; Berta, Stefano; Lonsdale, Carol; Smith, Gene; Shupe, David; Surace, Jason; Arnouts, Stephane; LeFevre, Olivier; Afonso-Luis, Alejandro; Perez-Fournon, Ismael; Hatziminaoglou, Evanthia; Polletta, Maria; Farrah, Duncan; Vaccari, Mattia

    2008-01-01

    We present the SWIRE Photometric Redshift Catalogue, 1024750 redshifts of unprecedented reliability and accuracy. Our method is based on fixed galaxy and QSO templates applied to data at 0.36-4.5 mu, and on a set of 4 infrared emission templates fitted to infrared excess data at 3.6-170 mu. The code involves two passes through the data, to try to optimize recognition of AGN dust tori. A few carefully justified priors are used and are the key to supression of outliers. Extinction, A_V, is allowed as a free parameter. We use a set of 5982 spectroscopic redshifts, taken from the literature and from our own spectroscopic surveys, to analyze the performance of our method as a function of the number of photometric bands used in the solution and the reduced chi^2. For 7 photometric bands the rms value of (z_{phot}-z_{spec})/(1+z_{spec}) is 3.5%, and the percentage of catastrophic outliers is ~1%. We discuss the redshift distributions at 3.6 and 24 mu. In individual fields, structure in the redshift distribution corr...

  18. Measuring Gravitational Redshifts in Galaxy Clusters

    CERN Document Server

    Kaiser, Nick

    2013-01-01

    Wojtak {\\it et al} have stacked 7,800 clusters from the SDSS survey in redshift space. They find a small net blue-shift for the cluster galaxies relative to the brightest cluster galaxies, which agrees quite well with the gravitational redshift from GR. Zhao {\\it et al.} have pointed out that, in addition to the gravitational redshift, one would expect to see transverse Doppler (TD) redshifts, and that these two effects are generally of the same order. Here we show that there are other corrections that are also of the same order of magnitude. The fact that we observe galaxies on our past light cone results in a bias such that more of the galaxies observed are moving away from us in the frame of the cluster than are moving towards us. This causes the observed average redshift to be $\\langle \\delta z \\rangle = -\\langle \\Phi \\rangle + \\langle \\beta^2 \\rangle / 2 + \\langle \\beta_x^2 \\rangle$, with $\\beta_x$ is the line of sight velocity. That is if we average over galaxies with equal weight. If the galaxies in ea...

  19. Evidence that plasma concentration rather than dose per kilogram body weight predicts ribavirin-induced anaemia.

    Science.gov (United States)

    Lindahl, K; Schvarcz, R; Bruchfeld, A; Ståhle, L

    2004-01-01

    Ribavirin in combination with interferon alpha-2 or pegylated interferon is the standard treatment for chronic hepatitis C. The current dosage recommendations for ribavirin are based on body weight (bw). Ribavirin is mainly eliminated by the kidneys and we have recently shown that ribavirin plasma concentrations are determined primarily by renal function. It is therefore reasonable to hypothesize that side-effects of ribavirin, i.e. anaemia, should be more closely related to plasma concentrations of ribavirin than to the dose per kg bw. A total of 108 consecutive patients eligible for treatment of chronic hepatitis C were studied. Ribavirin concentrations in plasma were measured by high-performance liquid chromatography (HPLC)-UV after solid-phase extraction in trough samples taken 4, 8 and 12 weeks after the treatment commenced. A total of 213 samples were obtained and the change in the haemoglobin level and the creatinine concentration was measured in addition to ribavirin. The dose of ribavirin per kg bw did not correlate with the drop in haemoglobin level induced by ribavirin. The concentration of ribavirin was non-linearly related to the drop in the haemoglobin level as revealed by fitting a standard Hill equation type dose-response curve. The half maximal drop in haemoglobin was obtained at 4.4 microm. The results from this study suggest that the anaemia induced by ribavirin depends primarily on the concentration of ribavirin, and not on the dose per kg bw. This lends further support to the idea that ribavirin should be dosed according to renal function.

  20. Plasma levels of catecholamine metabolites predict the response to sulpiride or fluvoxamine in major depression.

    Science.gov (United States)

    Ueda, N; Yoshimura, R; Shinkai, K; Nakamura, J

    2002-09-01

    We investigated the relationships between the changes in plasma catecholamine metabolites obtained from depressed patients before and after administration of sulpiride, a benzamide compound, or fluvoxamine, a selective serotonin reuptake inhibitor (SSRI), and between clinical responses to treatment with each of these drugs. Responders to sulpiride had significantly lower plasma homovanillic acid (pHVA) levels before administration of sulpiride than did non-responders or controls (responders: 4.5 +/- 3.1 ng/ml, non-responders: 11.1 +/- 5.9 ng/ml, controls: 10.9 +/- 5.3 ng/ml). Positive relationships were observed between changes in pHVA levels and improvement rates in the 17-item Hamilton Depression Rating Scale (Ham-D). In contrast, responders to fluvoxamine had significantly higher plasma free 3-methoxy-4-hydroxyphenylglycol (pMHPG) levels before administration of fluvoxamine than did non-responders or controls (responders: 8.5 +/- 1.8 ng/ml, non-responders: 5.9 +/- 2.I ng/ml, controls: 5.2 +/- 2.9 ng/ml). Negative relationships were observed between changes in pMHPG levels and improvement rates in Ham-D. These results suggest that lower pretreatment pHVA levels and higher pretreatment levels of pMHPG might be predictors of response to sulpiride and fluvoxamine, respectively, and that sulpiride might produce a functional increase in the dopaminergic system, resulting in improvement in some depressive symptoms; fluvoxamine, on the other hand, might produce a functional decrease in the noradrenergic system via serotonergic neurons, resulting in improvement of those symptoms.

  1. Optimized Clustering Estimators for BAO Measurements Accounting for Significant Redshift Uncertainty

    Energy Technology Data Exchange (ETDEWEB)

    Ross, Ashley J. [Portsmouth U., ICG; Banik, Nilanjan [Fermilab; Avila, Santiago [Madrid, IFT; Percival, Will J. [Portsmouth U., ICG; Dodelson, Scott [Fermilab; Garcia-Bellido, Juan [Madrid, IFT; Crocce, Martin [ICE, Bellaterra; Elvin-Poole, Jack [Jodrell Bank; Giannantonio, Tommaso [Cambridge U., KICC; Manera, Marc [Cambridge U., DAMTP; Sevilla-Noarbe, Ignacio [Madrid, CIEMAT

    2017-05-15

    We determine an optimized clustering statistic to be used for galaxy samples with significant redshift uncertainty, such as those that rely on photometric redshifts. To do so, we study the BAO information content as a function of the orientation of galaxy clustering modes with respect to their angle to the line-of-sight (LOS). The clustering along the LOS, as observed in a redshift-space with significant redshift uncertainty, has contributions from clustering modes with a range of orientations with respect to the true LOS. For redshift uncertainty $\\sigma_z \\geq 0.02(1+z)$ we find that while the BAO information is confined to transverse clustering modes in the true space, it is spread nearly evenly in the observed space. Thus, measuring clustering in terms of the projected separation (regardless of the LOS) is an efficient and nearly lossless compression of the signal for $\\sigma_z \\geq 0.02(1+z)$. For reduced redshift uncertainty, a more careful consideration is required. We then use more than 1700 realizations of galaxy simulations mimicking the Dark Energy Survey Year 1 sample to validate our analytic results and optimized analysis procedure. We find that using the correlation function binned in projected separation, we can achieve uncertainties that are within 10 per cent of of those predicted by Fisher matrix forecasts. We predict that DES Y1 should achieve a 5 per cent distance measurement using our optimized methods. We expect the results presented here to be important for any future BAO measurements made using photometric redshift data.

  2. Observations of GRBs at high redshift.

    Science.gov (United States)

    Tanvir, Nial R; Jakobsson, Páll

    2007-05-15

    The extreme luminosity of gamma-ray bursts and their afterglows means they are detectable, in principle, to very high redshifts. Although the redshift distribution of gamma-ray bursts (GRBs) is difficult to determine, due to incompleteness of present samples, we argue that for Swift-detected bursts, the median redshift is between 2.5 and 3, with a few per cent probably at z>6. Thus, GRBs are potentially powerful probes of the era of reionization and the sources responsible for it. Moreover, it seems probable that they can provide constraints on the star-formation history of the Universe and may also help in the determination of the cosmological parameters.

  3. Testing the Gravitational Redshift with Atomic Gravimeters?

    CERN Document Server

    Wolf, Peter; Bordé, Christian J; Reynaud, Serge; Salomon, Christophe; Cohen-Tannoudji, Claude

    2011-01-01

    Atom interferometers allow the measurement of the acceleration of freely falling atoms with respect to an experimental platform at rest on Earth's surface. Such experiments have been used to test the universality of free fall by comparing the acceleration of the atoms to that of a classical freely falling object. In a recent paper, M\\"uller, Peters and Chu [Nature {\\bf 463}, 926-929 (2010)] argued that atom interferometers also provide a very accurate test of the gravitational redshift (or universality of clock rates). Considering the atom as a clock operating at the Compton frequency associated with the rest mass, they claimed that the interferometer measures the gravitational redshift between the atom-clocks in the two paths of the interferometer at different values of gravitational potentials. In the present paper we analyze this claim in the frame of general relativity and of different alternative theories, and conclude that the interpretation of atom interferometers as testing the gravitational redshift ...

  4. Distribution function approach to redshift space distortions

    CERN Document Server

    Seljak, Uros

    2011-01-01

    We develop a phase space distribution function approach to redshift space distortions (RSD), in which the redshift space density can be written as a sum over velocity moments of the distribution function. These moments are density weighted and their lowest orders are density, momentum density, and stress energy density. The series expansion is convergent on large scales. We perform an expansion of these velocity moments into helicity modes, which are eigenmodes under rotation around the axis of Fourier mode direction, generalizing the scalar, vector, tensor decomposition of perturbations to an arbitrary order. We show that only equal helicity moments correlate and derive the angular dependence of the individual contributions to the redshift space power spectrum in terms of angle mu between wave vector and line of sight. We show that the dominant term of mu^2 dependence on large scales is the cross-correlation between the density and scalar part of momentum density, which can be related to the time derivative ...

  5. Measuring our Universe from Galaxy Redshift Surveys

    Directory of Open Access Journals (Sweden)

    Lahav Ofer

    2004-07-01

    Full Text Available Galaxy redshift surveys have achieved significant progress over the last couple of decades. Those surveys tell us in the most straightforward way what our local Universe looks like. While the galaxy distribution traces the bright side of the Universe, detailed quantitative analyses of the data have even revealed the dark side of the Universe dominated by non-baryonic dark matter as well as more mysterious dark energy (or Einstein's cosmological constant. We describe several methodologies of using galaxy redshift surveys as cosmological probes, and then summarize the recent results from the existing surveys. Finally we present our views on the future of redshift surveys in the era of precision cosmology.

  6. Photometric redshifts with the Multilayer Perceptron Neural Network: application to the HDF-S and SDSS

    CERN Document Server

    Vanzella, E; Fontana, A; Nonino, M; Arnouts, S; Giallongo, E; Grazian, A; Fasano, G; Popesso, P; Saracco, P; Zaggia, S R

    2003-01-01

    We present a technique for the estimation of photometric redshifts based on feed-forward neural networks. The Multilayer Perceptron (MLP) Artificial Neural Network is used to predict photometric redshifts in the HDF-S from an ultra deep multicolor catalog. Various possible approaches for the training of the neural network are explored, including the deepest and most complete spectroscopic redshift catalog currently available (the Hubble Deep Field North dataset) and models of the spectral energy distribution of galaxies available in the literature. The MLP can be trained on observed data, theoretical data and mixed samples. The prediction of the method is tested on the spectroscopic sample in the HDF-S (44 galaxies). Over the entire redshift range, $0.1redshifts in the HDF-S is good: the training on mixed data produces sigma_z(test) ~ 0.11, showing that model libraries together with observed data provide a sufficiently complete description...

  7. Soluble Urokinase-Type Plasminogen Activator Receptor Plasma Concentration May Predict Susceptibility to High Altitude Pulmonary Edema

    Science.gov (United States)

    Zügel, Stefanie; Schoeb, Michele; Auinger, Katja; Dehnert, Christoph; Maggiorini, Marco

    2016-01-01

    Introduction. Acute exposure to high altitude induces inflammation. However, the relationship between inflammation and high altitude related illness such as high altitude pulmonary edema (HAPE) and acute mountain sickness (AMS) is poorly understood. We tested if soluble urokinase-type plasminogen activator receptor (suPAR) plasma concentration, a prognostic factor for cardiovascular disease and marker for low grade activation of leukocytes, will predict susceptibility to HAPE and AMS. Methods. 41 healthy mountaineers were examined at sea level (SL, 446 m) and 24 h after rapid ascent to 4559 m (HA). 24/41 subjects had a history of HAPE and were thus considered HAPE-susceptible (HAPE-s). Out of the latter, 10/24 HAPE-s subjects were randomly chosen to suppress the inflammatory cascade with dexamethasone 8 mg bid 24 h prior to ascent. Results. Acute hypoxic exposure led to an acute inflammatory reaction represented by an increase in suPAR (1.9 ± 0.4 at SL versus 2.3 ± 0.5 at HA, p < 0.01), CRP (0.7 ± 0.5 at SL versus 3.6 ± 4.6 at HA, p < 0.01), and IL-6 (0.8 ± 0.4 at SL versus 3.3 ± 4.9 at HA, p < 0.01) in all subjects except those receiving dexamethasone. The ascent associated decrease in PaO2 correlated with the increase in IL-6 (r = 0.46, p < 0.001), but not suPAR (r = 0.27, p = 0.08); the increase in IL-6 was not correlated with suPAR (r = 0.16, p = 0.24). Baseline suPAR plasma concentration was higher in the HAPE-s group (2.0 ± 0.4 versus 1.8 ± 0.4, p = 0.04); no difference was found for CRP and IL-6 and for subjects developing AMS. Conclusion. High altitude exposure leads to an increase in suPAR plasma concentration, with the missing correlation between suPAR and IL-6 suggesting a cytokine independent, leukocyte mediated mechanism of low grade inflammation. The correlation between IL-6 and PaO2 suggests a direct effect of hypoxia, which is not the case for suPAR. However, suPAR plasma concentration measured before hypoxic exposure may predict

  8. -Rays Radiation of High Redshift Fermi Blazars

    Indian Academy of Sciences (India)

    W. G. Liu; S. H. Fu; X. Zhang; L. Ma; Y. B. Li; D. R. Xiong

    2014-09-01

    Based on the 31 high redshift ( > 2) Flat Spectral Radio Quasars (FSRQs), which is from the second Fermi-LAT AGNs catalogue (2LAC), we studied the correlation between flux densities (R, K, ) in the radio, infrared and -ray wave bands. We found that there is a significant positive correlation between and R, and a weak anticorrelation between and K in the average state. For high redshift blazars, we argue that the seed photon of -ray emission mainly comes from the jet itself and partially from the dusty torus.

  9. High Redshift Quasars and Star Formation History

    CERN Document Server

    Dietrich, M; Dietrich, Matthias; Hamann, Fred

    2001-01-01

    Quasars are among the most luminous objects in the universe, and they can be studied in detail up to the highest known redshift. Assuming that the gas associated with quasars is closely related to the interstellar medium of the host galaxy, quasars can be used as tracer of the star formation history in the early universe. We have observed a small sample of quasars at redshifts 3= 10, corresponding to an age of the universe of less than 5*10^8 yrs (H_o = 65 km/s/Mpc, Omega_M = 0.3, Omega_Lambda = 0.7).

  10. Anomalous Redshift of Some Galactic Objects

    CERN Document Server

    Zheng, Yi-Jia

    2013-01-01

    Anomalous redshifts of some galactic objects such as binary stars, early-type stars in the solar neighborhood, and O stars in a star clusters are discussed. It is shown that all these phenomena have a common characteristic, that is, the redshifts of stars increase as the temperature rises. This characteristic cannot be explained by means of the Doppler Effect but can by means of the soft-photon process proposed by Yijia Zheng (arXiv:1305.0427 [astro-ph.HE]).

  11. A new method to search for high-redshift clusters using photometric redshifts

    Energy Technology Data Exchange (ETDEWEB)

    Castignani, G.; Celotti, A. [SISSA, Via Bonomea 265, I-34136 Trieste (Italy); Chiaberge, M.; Norman, C., E-mail: castigna@sissa.it [Space Telescope Science Institute, 3700 San Martin Drive, Baltimore, MD 21218 (United States)

    2014-09-10

    We describe a new method (Poisson probability method, PPM) to search for high-redshift galaxy clusters and groups by using photometric redshift information and galaxy number counts. The method relies on Poisson statistics and is primarily introduced to search for megaparsec-scale environments around a specific beacon. The PPM is tailored to both the properties of the FR I radio galaxies in the Chiaberge et al. sample, which are selected within the COSMOS survey, and to the specific data set used. We test the efficiency of our method of searching for cluster candidates against simulations. Two different approaches are adopted. (1) We use two z ∼ 1 X-ray detected cluster candidates found in the COSMOS survey and we shift them to higher redshift up to z = 2. We find that the PPM detects the cluster candidates up to z = 1.5, and it correctly estimates both the redshift and size of the two clusters. (2) We simulate spherically symmetric clusters of different size and richness, and we locate them at different redshifts (i.e., z = 1.0, 1.5, and 2.0) in the COSMOS field. We find that the PPM detects the simulated clusters within the considered redshift range with a statistical 1σ redshift accuracy of ∼0.05. The PPM is an efficient alternative method for high-redshift cluster searches that may also be applied to both present and future wide field surveys such as SDSS Stripe 82, LSST, and Euclid. Accurate photometric redshifts and a survey depth similar or better than that of COSMOS (e.g., I < 25) are required.

  12. PCSK9 Plasma Concentrations Are Independent of GFR and Do Not Predict Cardiovascular Events in Patients with Decreased GFR.

    Directory of Open Access Journals (Sweden)

    Kyrill S Rogacev

    Full Text Available Impaired renal function causes dyslipidemia that contributes to elevated cardiovascular risk in patients with chronic kidney disease (CKD. The proprotein convertase subtilisin/kexin type 9 (PCSK9 is a regulator of the LDL receptor and plasma cholesterol concentrations. Its relationship to kidney function and cardiovascular events in patients with reduced glomerular filtration rate (GFR has not been explored.Lipid parameters including PCSK9 were measured in two independent cohorts. CARE FOR HOMe (Cardiovascular and Renal Outcome in CKD 2-4 Patients-The Forth Homburg evaluation enrolled 443 patients with reduced GFR (between 90 and 15 ml/min/1.73 m2 referred for nephrological care that were prospectively followed for the occurrence of a composite cardiovascular endpoint. As a replication cohort, PCSK9 was quantitated in 1450 patients with GFR between 90 and 15 ml/min/1.73 m2 enrolled in the Ludwigshafen Risk and Cardiovascular Health Study (LURIC that were prospectively followed for cardiovascular deaths.PCSK9 concentrations did not correlate with baseline GFR (CARE FOR HOMe: r = -0.034; p = 0.479; LURIC: r = -0.017; p = 0.512. 91 patients in CARE FOR HOMe and 335 patients in LURIC reached an endpoint during a median follow-up of 3.0 [1.8-4.1] years and 10.0 [7.3-10.6] years, respectively. Kaplan-Meier analyses showed that PCSK9 concentrations did not predict cardiovascular events in either cohort [CARE FOR HOMe (p = 0.622; LURIC (p = 0.729]. Sensitivity analyses according to statin intake yielded similar results.In two well characterized independent cohort studies, PCSK9 plasma levels did not correlate with kidney function. Furthermore, PCSK9 plasma concentrations were not associated with cardiovascular events in patients with reduced renal function.

  13. Biorelevant in vitro dissolution testing of products containing micronized or nanosized fenofibrate with a view to predicting plasma profiles.

    Science.gov (United States)

    Juenemann, Daniel; Jantratid, Ekarat; Wagner, Christian; Reppas, Christos; Vertzoni, Maria; Dressman, Jennifer B

    2011-02-01

    The ability of in vitro biorelevant dissolution tests to predict the in vivo performance of nanosized fenofibrate (Lipidil 145 ONE®) and microsized fenofibrate (Lipidil - Ter®) was evaluated in this study. In vitro dissolution was carried out using USP apparatus 2 (paddle method) with updated biorelevant media to simulate the pre- and postprandial states. Membrane filters with different pore sizes were evaluated for their ability to hold back undissolved, nanosized drug particles. It was shown that filters with pore sizes of 0.1 μm and 0.02 μm were able to separate molecularly dissolved drug from colloidal and undissolved particles. In vitro results obtained with a suitable filter were used to generate simulated plasma profiles in combination with two different models using STELLA® software: (a) under the assumption of no permeability restrictions to absorption and (b) under the assumption of a permeability restriction. The simulated plasma profiles were compared to in vivo data for the nanosized and the microsized formulation in the fasted and fed states. The first model approach resulted in good correlation for the microsized fenofibrate formulation, but the plasma profile of the formulation containing nanosized fenofibrate was overpredicted in the fasted state. The second model successfully correlated with in vivo data for both formulations, regardless of prandial state. Comparison of simulations with the two models indicates that in the fasted state, absorption of fenofibrate from the nanosized formulation is at least partly permeability-limited, while for the microsized formulation the dissolution of fenofibrate appears to be rate-determining. Copyright © 2010 Elsevier B.V. All rights reserved.

  14. Plasma neutrophil gelatinase-associated lipocalin as a marker for the prediction of worsening renal function in children hospitalized for acute heart failure.

    Science.gov (United States)

    Elsharawy, Sahar; Raslan, Lila; Morsy, Saed; Hassan, Basheir; Khalifa, Naglaa

    2016-01-01

    Acute heart failure (AHF) is frequently associated with worsening renal function in adult patients. Neutrophil gelatinase-associated lipocalin (NGAL) serves as an early marker for acute renal tubular injury. To assess the role of plasma NGAL in predicting worsening renal function (WRF) in children with AHF, we studied 30 children hospitalized for AHF; children with history of chronic renal disease or on nephrotoxic drugs were excluded. Twenty age- and sex-matched healthy children were included in the study as a control group. Echocardiographic examination was performed on admission. Blood urea nitrogen (BUN), serum creatinine, estimated glomerular filtration rate (eGFR) and plasma NGAL levels were measured on admission and 72 h later. Seventeen (56.6%) patients developed WRF within the three-day follow-up period. At presentation, plasma NGAL level was significantly elevated in children who developed WRF. Admission plasma NGAL level correlated with renal parameters (BUN, creatinine and eGFR) as well as with left ventricular systolic parameters (ejection fraction and fractional shortening). For prediction of WRF, admission plasma, NGAL level>27.5 μg/L had sensitivity and specificity of 90% and 68%, respectively. The area under the receiver-operator curve was higher for NGAL (0.869) than for BUN (0.569) or eGFR (0.684). We conclude that admission plasma NGAL level can predict WRF in children hospitalized for AHF.

  15. Predictions and observations of low-shear beta-induced shear Alfven-acoustic eigenmodes in toroidal plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Gorelenkov, N.N. [Princeton Plasma Physics Laboratory, Princeton University (United States)], E-mail: ngorelen@pppl.gov; Berk, H.L. [IFS, Austin, Texas (United States); Fredrickson, E. [Princeton Plasma Physics Laboratory, Princeton University (United States); Sharapov, S.E. [Euroatom/UKAEA Fusion Association, Culham Science Centre, Abingdon, Oxfordshire (United States)

    2007-10-08

    New global MHD eigenmode solutions arising in gaps in the low frequency Alfven-acoustic continuum below the geodesic acoustic mode (GAM) frequency have been found numerically and have been used to explain relatively low frequency experimental signals seen in NSTX and JET tokamaks. These global eigenmodes, referred to here as Beta-induced Alfven-Acoustic Eigenmodes (BAAE), exist in the low magnetic safety factor region near the extrema of the Alfven-acoustic continuum. In accordance to the linear dispersion relations, the frequency of these modes shifts as the safety factor, q, decreases. We show that BAAEs can be responsible for observations in JET plasmas at relatively low beta <2% as well as in NSTX plasmas at relatively high-beta >20%. In contrast to the mostly electrostatic character of GAMs the new global modes also contain an electromagnetic (magnetic field line bending) component due to the Alfven coupling, leading to wave phase velocities along the field line that are large compared to the sonic speed. Qualitative agreement between theoretical predictions and observations are found.

  16. High SPARC Expression Starting from Dysplasia, Associated with Breast Carcinoma, Is Predictive for Bone Metastasis without Enhancement of Plasma Levels

    Science.gov (United States)

    Maroni, Paola; Bendinelli, Paola; Morelli, Daniele; Drago, Lorenzo; Luzzati, Alessandro; Perrucchini, Giuseppe; Bonini, Chiara; Matteucci, Emanuela; Desiderio, Maria Alfonsina

    2015-01-01

    In order to become established in the skeleton, metastatic cells disseminating from the breast carcinoma need to acquire organ-specific traits. There are no effective predictors for who will develop bone metastasis to guide long-term predictive therapy. Our purpose was to individuate events critical for bone colonization to make a molecular classification of breast carcinoma useful for bone-metastasis outcome. In dysplasia adjacent to carcinoma and in pair-matched specimens of bone metastasis we examined SPARC expression and localization as well as Endothelin 1/ETAR signals by immunohistochemistry, and the evaluation of plasma levels of SPARC by ELISA was also performed. In patients with breast carcinoma metastasizing to bone, SPARC and Endothelin 1/ETAR axis were highly expressed from dysplasia until bone metastasis, but the SPARC plasma level was as low as that of normal women, in contrast to patients that never develop bone metastasis, suggesting that circulating SPARC was counter adhesive. Altogether, the early identification of SPARC/Endothelin 1/ETAR in dysplastic lesions would be important to devise therapies preventing metastasis engraftment, since often carcinoma cells spread to distant organs at the time or even before patients present with cancer. PMID:26703564

  17. Challenges in the extrapolation from DD to DT plasmas: experimental analysis and theory based predictions for JET-DT

    Science.gov (United States)

    Garcia, J.; Challis, C.; Gallart, D.; Garzotti, L.; Görler, T.; King, D.; Mantsinen, M.; contributors, JET

    2017-01-01

    A strong modelling program has been started in support of the future JET-DT campaign with the aim of guiding experiments in deuterium (D) towards maximizing fusion energy production in Deuterium-Tritium (DT). Some of the key elements have been identified by using several of the most updated and sophisticated models for predicting heat and particle transport, pedestal pressure and heating sources in an integrated modelling framework. For the high beta and low gas operational regime, the density plays a critical role and a trend towards higher fusion power is obtained at lower densities. Additionally, turbulence stabilization by E  ×  B flow shear is shown to generate an isotope effect leading to higher confinement for DT than DD and therefore plasmas with high torque are suitable for maximizing fusion performance. Future JET campaigns will benefit from this modelling activity by defining clear priorities on their scientific program.

  18. Galaxy formation in the PLANCK cosmology IV: the high-redshift universe

    CERN Document Server

    Clay, Scott; Wilkins, Stephen; Henriques, Bruno

    2015-01-01

    We present high-redshift predictions of the star-formation-rate distribution function (SFR DF), UV luminosity function (UV LF), galactic stellar mass function (GSMF), and specific star-formation rates (sSFRs) of galaxies from the latest version of the Munich semi-analytic model L-Galaxies. We find a good fit to both the shape and normalisation of the SFR DF at $z=4-7$, apart from a slight under-prediction at the low SFR end at $z=4$. Likewise, we find a good fit to the faint number counts for the observed UV LF; at brighter magnitudes our predictions lie below the observations, increasingly so at higher redshifts. At all redshifts and magnitudes, the raw (unattenuated) number counts for the UV LF lie above the observations. Because of the good agreement with the SFR we interpret our under-prediction as an over-estimate of the amount of dust in the model for the brightest galaxies, especially at high-redshift. While the shape of our GSMF matches that of the observations, we lie between (conflicting) observatio...

  19. The effect of large amplitude motions on the transition frequency redshift in hydrogen bonded complexes

    DEFF Research Database (Denmark)

    Mackeprang, Kasper; Kjærgaard, Henrik Grum; Salmi, Teemu

    2014-01-01

    -stretching transition. The model accurately predicts the transition wavenumbers of the vibrations in water dimer compared to experimental values and provides a physical picture that explains the redshift of the hydrogen bonded OH-oscillator. We find that it is unnecessary to include all six intermolecular modes...

  20. Structure formation simulations with momentum exchange: alleviating tensions between high-redshift and low-redshift cosmological probes

    Science.gov (United States)

    Baldi, Marco; Simpson, Fergus

    2017-02-01

    Persisting tensions between the cosmological constraints derived from low-redshift probes and the ones obtained from temperature and polarization anisotropies of the cosmic microwave background (CMB) - although not yet providing compelling evidence against the Λcold dark matter model - seem to consistently indicate a slower growth of density perturbations as compared to the predictions of the standard cosmological scenario. Such behaviour is not easily accommodated by the simplest extensions of General Relativity, such as f(R) models, which generically predict an enhanced growth rate. In this work, we present the outcomes of a suite of large N-body simulations carried out in the context of a cosmological model featuring a non-vanishing scattering cross-section between the dark matter and the dark energy fields, for two different parametrizations of the dark energy equation of state. Our results indicate that these dark scattering models have very mild effects on many observables related to large-scale structures formation and evolution, while providing a significant suppression of the amplitude of linear density perturbations and the abundance of massive clusters. Our simulations therefore confirm that these models offer a promising route to alleviate existing tensions between low-redshift measurements and those of the CMB.

  1. Prediction of the effect on antihyperglycaemic action of sitagliptin by plasma active form glucagon-like peptide-1

    Institute of Scientific and Technical Information of China (English)

    Akifumi; Kushiyama; Takako; Kikuchi; Kentaro; Tanaka; Tazu; Tahara; Toshiko; Takao; Yukiko; Onishi; Yoko; Yoshida; Shoji; Kawazu; Yasuhiko; Iwamoto

    2016-01-01

    AIM: To investigate whether active glucagon-like peptide-1(GLP-1) is a prediction Factor of Effect of sitagliptin on patients with type 2 diabetes mellitus(GLP-1 FEST:UMIN000010645). METHODS: Seventy-six patients with type 2 diabetes, who had insufficient glycemic control [Hemoglobin A1c(Hb A1c) ≥ 7%] in spite of treatment with metformin and/or sulfonylurea, were included in the investigation. Patients were divided into three groups by tertiles of fasting plasma active GLP-1 level, before the administration of 50 mg sitagliptin. RESULTS: At baseline, body mass index, serum UA, insulin and HOMA-IR were higher in the high active GLP-1 group than in the other two groups. The high active GLP-1 group did not show any decline of Hb A1c(7.6% ± 1.4% to 7.5% ± 1.5%), whereas the middle and low groups indicated significant decline of Hb A1c(7.4 ± 0.7 to 6.8 ± 0.6 and 7.4 ± 1.2 to 6.9 ± 1.3, respectively) during six months. Only the low and middle groups showed a significant increment of active GLP-1, C-peptide level, a decreased log and proinsulin/insulin ratio after administration. In logistic analysis, the low or middle group is a significantexplanatory variable for an Hb A1 c decrease of ≥ 0.5%, and its odds ratio is 4.5(1.40-17.6)(P = 0.01) against the high active GLP-1 group. This remains independent when adjusted for Hb A1 c level before administration, patients’ medical history, medications, insulin secretion and insulin resistance.CONCLUSION: Plasma fasting active GLP-1 is an independent predictive marker for the efficacy of dipeptidyl peptidase 4 inhibitor sitagliptin.

  2. Multiphase Gas in Intermediate Redshift Galaxies

    CERN Document Server

    Churchill, C W; Charlton, J; Januzzi, B; Churchill, Chris; Mellon, Rick; Charlton, Jane

    2000-01-01

    We present 40 quasar absorption line systems at intermediate redshifts (z~1), with focus on one of the most kinematically complex known, as examples of how the unique capabilities of space-based and ground-based facilities can be combined to glean much broader insights into astrophysical systems.

  3. MARZ: Manual and automatic redshifting software

    Science.gov (United States)

    Hinton, S. R.; Davis, Tamara M.; Lidman, C.; Glazebrook, K.; Lewis, G. F.

    2016-04-01

    The Australian Dark Energy Survey (OzDES) is a 100-night spectroscopic survey underway on the Anglo-Australian Telescope using the fibre-fed 2-degree-field (2dF) spectrograph. We have developed a new redshifting application MARZ with greater usability, flexibility, and the capacity to analyse a wider range of object types than the RUNZ software package previously used for redshifting spectra from 2dF. MARZ is an open-source, client-based, Javascript web-application which provides an intuitive interface and powerful automatic matching capabilities on spectra generated from the AAOmega spectrograph to produce high quality spectroscopic redshift measurements. The software can be run interactively or via the command line, and is easily adaptable to other instruments and pipelines if conforming to the current FITS file standard is not possible. Behind the scenes, a modified version of the AUTOZ cross-correlation algorithm is used to match input spectra against a variety of stellar and galaxy templates, and automatic matching performance for OzDES spectra has increased from 54% (RUNZ) to 91% (MARZ). Spectra not matched correctly by the automatic algorithm can be easily redshifted manually by cycling automatic results, manual template comparison, or marking spectral features.

  4. Cosmography with high-redshift probes

    Science.gov (United States)

    Vitagliano, Vincenzo

    2014-05-01

    I discuss how the cosmographic approach to the determination of cosmological parameters can be implemented with the inclusion of high-redshift data. I argue on the viability of such high-z probes for cosmographic purposes, and resume some statistical issues in finding the most reliable cosmographic truncation.

  5. Identifying high-redshift GRBs with RATIR

    CERN Document Server

    Littlejohns, O M; Cucchiara, A; Watson, A M; Kutyrev, A S; Lee, W H; Richer, M G; Klein, C R; Fox, O D; Prochaska, J X; Bloom, J S; Troja, E; Ramirez-Ruiz, E; de Diego, J A; Georgiev, L; González, J; Román-Zúñiga, C G; Gehrels, N; Moseley, H

    2013-01-01

    We present a template fitting algorithm for determining photometric redshifts, $z_{\\rm phot}$, of candidate high-redshift gamma-ray bursts (GRBs). Using afterglow photometry, obtained by the Reionization And Transients InfraRed (RATIR) camera, this algorithm accounts for the intrinsic GRB afterglow spectrum, host dust extinction and the effect of neutral hydrogen (local and cosmological) along the line of sight. We present the results obtained by this algorithm and RATIR photometry of GRB 130606A, finding $z_{\\rm phot} = 6.01_{-0.08}^{+0.16}$ for a model with negligible host dust extinction, consistent with spectroscopic measurements of the redshift of this GRB. Using simulated RATIR photometry, we find our algorithm provides precise measures of $z_{\\rm phot}$ in the ranges $4 4$. Further testing highlights the required caution in cases of highly dust extincted host galaxies. These tests also show that our algorithm minimizes false negatives thus allowing us to rapidly identify all potential high-redshift eve...

  6. The environment and redshift dependence of accretion onto dark matter halos and subhalos

    OpenAIRE

    Tillson, Henry; Miller, Lance; Devriendt, Julien

    2011-01-01

    A dark-matter-only Horizon Project simulation is used to investigate the environment- and redshift- dependence of accretion onto both halos and subhalos. These objects grow in the simulation via mergers and via accretion of diffuse non-halo material, and we measure the combined signal from these two modes of accretion. It is found that the halo accretion rate varies less strongly with redshift than predicted by the Extended Press-Schechter (EPS) formalism and is dominated by minor-merger and ...

  7. Mapping the Galaxy Color-Redshift Relation: Optimal Photometric Redshift Calibration Strategies for Cosmology Surveys

    CERN Document Server

    Masters, Daniel; Stern, Daniel; Ilbert, Olivier; Salvato, Mara; Schmidt, Samuel; Longo, Giuseppe; Rhodes, Jason; Paltani, Stephane; Mobasher, Bahram; Hoekstra, Henk; Hildebrandt, Hendrik; Coupon, Jean; Steinhardt, Charles; Speagle, Josh; Faisst, Andreas; Kalinich, Adam; Brodwin, Mark; Brescia, Massimo; Cavuoti, Stefano

    2015-01-01

    Calibrating the photometric redshifts of >10^9 galaxies for upcoming weak lensing cosmology experiments is a major challenge for the astrophysics community. The path to obtaining the required spectroscopic redshifts for training and calibration is daunting, given the anticipated depths of the surveys and the difficulty in obtaining secure redshifts for some faint galaxy populations. Here we present an analysis of the problem based on the self-organizing map, a method of mapping the distribution of data in a high-dimensional space and projecting it onto a lower-dimensional representation. We apply this method to existing photometric data from the COSMOS survey selected to approximate the anticipated Euclid weak lensing sample, enabling us to robustly map the empirical distribution of galaxies in the multidimensional color space defined by the expected Euclid filters. Mapping this multicolor distribution lets us determine where - in galaxy color space - redshifts from current spectroscopic surveys exist and whe...

  8. Correcting cosmological parameter biases for all redshift surveys induced by estimating and reweighting redshift distributions

    CERN Document Server

    Rau, Markus Michael; Paech, Kerstin; Seitz, Stella

    2016-01-01

    Photometric redshift uncertainties are a major source of systematic error for ongoing and future photometric surveys. We study different sources of redshift error caused by common suboptimal binning techniques and propose methods to resolve them. The selection of a too large bin width is shown to oversmooth small scale structure of the radial distribution of galaxies. This systematic error can significantly shift cosmological parameter constraints by up to $6 \\, \\sigma$ for the dark energy equation of state parameter $w$. Careful selection of bin width can reduce this systematic by a factor of up to 6 as compared with commonly used current binning approaches. We further discuss a generalised resampling method that can correct systematic and statistical errors in cosmological parameter constraints caused by uncertainties in the redshift distribution. This can be achieved without any prior assumptions about the shape of the distribution or the form of the redshift error. Our methodology allows photometric surve...

  9. Anomaly detection for machine learning redshifts applied to SDSS galaxies

    CERN Document Server

    Hoyle, Ben; Paech, Kerstin; Bonnett, Christopher; Seitz, Stella; Weller, Jochen

    2015-01-01

    We present an analysis of anomaly detection for machine learning redshift estimation. Anomaly detection allows the removal of poor training examples, which can adversely influence redshift estimates. Anomalous training examples may be photometric galaxies with incorrect spectroscopic redshifts, or galaxies with one or more poorly measured photometric quantity. We select 2.5 million 'clean' SDSS DR12 galaxies with reliable spectroscopic redshifts, and 6730 'anomalous' galaxies with spectroscopic redshift measurements which are flagged as unreliable. We contaminate the clean base galaxy sample with galaxies with unreliable redshifts and attempt to recover the contaminating galaxies using the Elliptical Envelope technique. We then train four machine learning architectures for redshift analysis on both the contaminated sample and on the preprocessed 'anomaly-removed' sample and measure redshift statistics on a clean validation sample generated without any preprocessing. We find an improvement on all measured stat...

  10. Accurate photometric redshift probability density estimation - method comparison and application

    CERN Document Server

    Rau, Markus Michael; Brimioulle, Fabrice; Frank, Eibe; Friedrich, Oliver; Gruen, Daniel; Hoyle, Ben

    2015-01-01

    We introduce an ordinal classification algorithm for photometric redshift estimation, which vastly improves the reconstruction of photometric redshift probability density functions (PDFs) for individual galaxies and galaxy samples. As a use case we apply our method to CFHTLS galaxies. The ordinal classification algorithm treats distinct redshift bins as ordered values, which improves the quality of photometric redshift PDFs, compared with non-ordinal classification architectures. We also propose a new single value point estimate of the galaxy redshift, that can be used to estimate the full redshift PDF of a galaxy sample. This method is competitive in terms of accuracy with contemporary algorithms, which stack the full redshift PDFs of all galaxies in the sample, but requires orders of magnitudes less storage space. The methods described in this paper greatly improve the log-likelihood of individual object redshift PDFs, when compared with a popular Neural Network code (ANNz). In our use case, this improvemen...

  11. Hierarchical Bayesian inference of galaxy redshift distributions from photometric surveys

    CERN Document Server

    Leistedt, Boris; Peiris, Hiranya V

    2016-01-01

    Accurately characterizing the redshift distributions of galaxies is essential for analysing deep photometric surveys and testing cosmological models. We present a technique to simultaneously infer redshift distributions and individual redshifts from photometric galaxy catalogues. Our model constructs a piecewise constant representation (effectively a histogram) of the distribution of galaxy types and redshifts, the parameters of which are efficiently inferred from noisy photometric flux measurements. This approach can be seen as a generalization of template-fitting photometric redshift methods and relies on a library of spectral templates to relate the photometric fluxes of individual galaxies to their redshifts. We illustrate this technique on simulated galaxy survey data, and demonstrate that it delivers correct posterior distributions on the underlying type and redshift distributions, as well as on the individual types and redshifts of galaxies. We show that even with uninformative priors, large photometri...

  12. Photometric Redshifts for the SDSS Early Data Release

    CERN Document Server

    Csabai, I; Connolly, A J; Szalay, A S; Györy, Z; Benítez, N; Annis, J; Brinkmann, J; Eisenstein, D J; Fukugita, M; Gunn, J; Kent, S; Lupton, R; Nichol, R C; Stoughton, C; Csabai, Istvan; Budavari, Tamas; Connolly, Andrew J.; Szalay, Alexander S.; Gyory, Zsuzsanna; Benitez, Narciso; Annis, Jim; Brinkmann, Jon; Eisenstein, Daniel; Fukugita, Masataka; Gunn, Jim; Kent, Stephen; Lupton, Robert; Nichol, Robert C.; Stoughton, Chris

    2003-01-01

    The Early Data Release from the Sloan Digital Sky survey provides one of the largest multicolor photometric catalogs currently available to the astronomical community. In this paper we present the first application of photometric redshifts to the $\\sim 6$ million extended sources within these data (with 1.8 million sources having $r' < 21$). Utilizing a range of photometric redshift techniques, from empirical to template and hybrid techniques, we investigate the statistical and systematic uncertainties present within the redshift estimates for the EDR data. For $r'<21$ we find that the redshift estimates provide realistic redshift histograms with an rms uncertainty in the photometric redshift relation of 0.035 at $r'<18$ and rising to 0.1 at $r'<21$. We conclude by describing how these photometric redshifts and derived quantities, such as spectral type, restframe colors and absolute magnitudes, are stored within the SDSS database. We provide sample queries for searching on photometric redshifts an...

  13. Prediction of Clinically Relevant Safety Signals of Nephrotoxicity through Plasma Metabolite Profiling

    Directory of Open Access Journals (Sweden)

    W. B. Mattes

    2013-01-01

    Full Text Available Addressing safety concerns such as drug-induced kidney injury (DIKI early in the drug pharmaceutical development process ensures both patient safety and efficient clinical development. We describe a unique adjunct to standard safety assessment wherein the metabolite profile of treated animals is compared with the MetaMap Tox metabolomics database in order to predict the potential for a wide variety of adverse events, including DIKI. To examine this approach, a study of five compounds (phenytoin, cyclosporin A, doxorubicin, captopril, and lisinopril was initiated by the Technology Evaluation Consortium under the auspices of the Drug Safety Executive Council (DSEC. The metabolite profiles for rats treated with these compounds matched established reference patterns in the MetaMap Tox metabolomics database indicative of each compound’s well-described clinical toxicities. For example, the DIKI associated with cyclosporine A and doxorubicin was correctly predicted by metabolite profiling, while no evidence for DIKI was found for phenytoin, consistent with its clinical picture. In some cases the clinical toxicity (hepatotoxicity, not generally seen in animal studies, was detected with MetaMap Tox. Thus metabolite profiling coupled with the MetaMap Tox metabolomics database offers a unique and powerful approach for augmenting safety assessment and avoiding clinical adverse events such as DIKI.

  14. Evaluating the accuracy of recent electron transport models at predicting Hall thruster plasma dynamics

    Science.gov (United States)

    Cappelli, Mark; Young, Christopher

    2016-10-01

    We present continued efforts towards introducing physical models for cross-magnetic field electron transport into Hall thruster discharge simulations. In particular, we seek to evaluate whether such models accurately capture ion dynamics, both averaged and resolved in time, through comparisons with measured ion velocity distributions which are now becoming available for several devices. Here, we describe a turbulent electron transport model that is integrated into 2-D hybrid fluid/PIC simulations of a 72 mm diameter laboratory thruster operating at 400 W. We also compare this model's predictions with one recently proposed by Lafluer et al.. Introducing these models into 2-D hybrid simulations is relatively straightforward and leverages the existing framework for solving the electron fluid equations. The models are tested for their ability to capture the time-averaged experimental discharge current and its fluctuations due to ionization instabilities. Model predictions are also more rigorously evaluated against recent laser-induced fluorescence measurements of time-resolved ion velocity distributions.

  15. Predictive factors of plasma HIV suppression during pregnancy: a prospective cohort study in Benin.

    Directory of Open Access Journals (Sweden)

    Lise Denoeud-Ndam

    Full Text Available OBJECTIVE: To investigate the factors associated with HIV1 RNA plasma viral load (pVL below 40 copies/mL at the third trimester of pregnancy, as part of prevention of mother-to-child transmission (PMTCT in Benin. DESIGN: Sub study of the PACOME clinical trial of malaria prophylaxis in HIV-infected pregnant women, conducted before and after the implementation of the WHO 2009 revised guidelines for PMTCT. METHODS: HIV-infected women were enrolled in the second trimester of pregnancy. Socio-economic characteristics, HIV history, clinical and biological characteristics were recorded. Malaria prevention and PMTCT involving antiretroviral therapy (ART for mothers and infants were provided. Logistic regression helped identifying factors associated with virologic suppression at the end of pregnancy. RESULTS: Overall 217 third trimester pVLs were available, and 71% showed undetectability. Virologic suppression was more frequent in women enrolled after the change in PMTCT recommendations, advising to start ART at 14 weeks instead of 28 weeks of pregnancy. In multivariate analysis, Fon ethnic group (the predominant ethnic group in the study area, regular job, first and second pregnancy, higher baseline pVL and impaired adherence to ART were negative factors whereas higher weight, higher antenatal care attendance and longer ART duration were favorable factors to achieve virologic suppression. CONCLUSIONS: This study provides more evidence that ART has to be initiated before the last trimester of pregnancy to achieve an undetectable pVL before delivery. In Benin, new recommendations supporting early initiation were well implemented and, together with a high antenatal care attendance, led to high rate of virologic control.

  16. Correcting cosmological parameter biases for all redshift surveys induced by estimating and reweighting redshift distributions

    Science.gov (United States)

    Rau, Markus Michael; Hoyle, Ben; Paech, Kerstin; Seitz, Stella

    2017-04-01

    Photometric redshift uncertainties are a major source of systematic error for ongoing and future photometric surveys. We study different sources of redshift error caused by choosing a suboptimal redshift histogram bin width and propose methods to resolve them. The selection of a too large bin width is shown to oversmooth small-scale structure of the radial distribution of galaxies. This systematic error can significantly shift cosmological parameter constraints by up to 6σ for the dark energy equation-of-state parameter w. Careful selection of bin width can reduce this systematic by a factor of up to 6 as compared with commonly used current binning approaches. We further discuss a generalized resampling method that can correct systematic and statistical errors in cosmological parameter constraints caused by uncertainties in the redshift distribution. This can be achieved without any prior assumptions about the shape of the distribution or the form of the redshift error. Our methodology allows photometric surveys to obtain unbiased cosmological parameter constraints using a minimum number of spectroscopic calibration data. For a DES-like galaxy clustering forecast, we obtain unbiased results with respect to errors caused by suboptimal histogram bin width selection, using only 5k representative spectroscopic calibration objects per tomographic redshift bin.

  17. SOMz: photometric redshift PDFs with self organizing maps and random atlas

    CERN Document Server

    Kind, M Carrasco

    2013-01-01

    In this paper we explore the applicability of the unsupervised machine learning technique of Self Organizing Maps (SOM) to estimate galaxy photometric redshift probability density functions (PDFs). This technique takes a spectroscopic training set, and maps the photometric attributes, but not the redshifts, to a two dimensional surface by using a process of competitive learning where neurons compete to more closely resemble the training data multidimensional space. The key feature of a SOM is that it retains the topology of the input set, revealing correlations between the attributes that are not easily identified. We test three different 2D topological mapping: rectangular, hexagonal, and spherical, by using data from the DEEP2 survey. We also explore different implementations and boundary conditions on the map and also introduce the idea of a random atlas where a large number of different maps are created and their individual predictions are aggregated to produce a more robust photometric redshift PDF. We a...

  18. Exploring The Gas Cycle In High-redshift Galaxies: A Joint Effort Of Theory And Observations

    Science.gov (United States)

    Fumagalli, Michele

    2012-01-01

    The evolution of high-redshift galaxies is regulated by the balance between the inflow of fresh fuel for star formation and the outflow of metal-polluted material from star forming regions. Hydrodynamic cosmological simulations indicate that galaxies at high redshifts are fed by extended streams of cold gas in a smooth component and in merging satellites, but direct evidence of this mode of accretion is lacking. To investigate the signatures of these "cold streams" in observations, we have studied the Lyman-α emission and hydrogen absorption properties in galaxies simulated at high-resolution, using state-of-the-art radiative transfer codes. I will present these model predictions and I will compare and contrast results of simulations with observations of high-redshift Lyman break galaxies. I will also discuss the prospects of mapping the circumgalactic medium with absorption line systems and present preliminary results from ongoing observations.

  19. Probing the accelerating Universe with redshift-space distortions in VIPERS

    Science.gov (United States)

    de la Torre, Sylvain

    2016-10-01

    We present the first measurement of the growth rate of structure at z=0.8. It has been obtained from the redshift-space distortions observed in the galaxy clustering pattern in the VIMOS Public Redshift survey (VIPERS) first data release. VIPERS is a large galaxy redshift survey probing the large-scale structure at 0.5 Universe, which has been poorly explored until now. We obtain σ8 = 0.47 +/- 0.08 at z = 0.8 that is consistent with the predictions of standard cosmological models based on Einstein gravity. This measurement alone is however not accurate enough to allow the detection of possible deviations from standard gravity.

  20. Redshift and blueshift in the spectra of lights coherently and diffusely scattered from random rough interfaces.

    Science.gov (United States)

    Dashtdar, Masoomeh; Tavassoly, M Taghi

    2009-10-01

    We show theoretically and experimentally that the spectrum of coherently scattered light from a randomly rough interface in reflection and transmission is redshifted with a shrinkage in spectral width. In reflection mode the amounts of the redshift and the shrinkage depend on interface roughness, incident angle, and the spectral width of the illuminating light. In transmission mode they also depend on the refractive indices of the surrounding media. The redshift and width shrinkage increase with decrease of the coherently scattered light intensity. This study shows that the spectrum of the diffusely scattered light is blueshifted in the specular direction and in directions with small scattering angles only in situations with appreciable intensity of the coherently scattered light. With decrease of the latter intensity the blueshift reduces and turns into redshift. Also, the redshift and blueshift decay with increase of the scattering angle. An experimental investigation has been carried out, on sheet glasses with different roughness on one side, in reflection and transmission modes. The experimental results and theoretical predictions are quite consistent.

  1. N-body simulations of gravitational redshifts and other relativistic distortions of galaxy clustering

    Science.gov (United States)

    Zhu, Hongyu; Alam, Shadab; Croft, Rupert A. C.; Ho, Shirley; Giusarma, Elena

    2017-10-01

    Large redshift surveys of galaxies and clusters are providing the first opportunities to search for distortions in the observed pattern of large-scale structure due to such effects as gravitational redshift. We focus on non-linear scales and apply a quasi-Newtonian approach using N-body simulations to predict the small asymmetries in the cross-correlation function of two galaxy different populations. Following recent work by Bonvin et al., Zhao and Peacock and Kaiser on galaxy clusters, we include effects which enter at the same order as gravitational redshift: the transverse Doppler effect, light-cone effects, relativistic beaming, luminosity distance perturbation and wide-angle effects. We find that all these effects cause asymmetries in the cross-correlation functions. Quantifying these asymmetries, we find that the total effect is dominated by the gravitational redshift and luminosity distance perturbation at small and large scales, respectively. By adding additional subresolution modelling of galaxy structure to the large-scale structure information, we find that the signal is significantly increased, indicating that structure on the smallest scales is important and should be included. We report on comparison of our simulation results with measurements from the SDSS/BOSS galaxy redshift survey in a companion paper.

  2. A distortion of very-high-redshift galaxy number counts by gravitational lensing.

    Science.gov (United States)

    Wyithe, J Stuart B; Yan, Haojing; Windhorst, Rogier A; Mao, Shude

    2011-01-13

    The observed number counts of high-redshift galaxy candidates have been used to build up a statistical description of star-forming activity at redshift z ≳ 7, when galaxies reionized the Universe. Standard models predict that a high incidence of gravitational lensing will probably distort measurements of flux and number of these earliest galaxies. The raw probability of this happening has been estimated to be ∼0.5 per cent (refs 11, 12), but can be larger owing to observational biases. Here we report that gravitational lensing is likely to dominate the observed properties of galaxies with redshifts of z ≳ 12, when the instrumental limiting magnitude is expected to be brighter than the characteristic magnitude of the galaxy sample. The number counts could be modified by an order of magnitude, with most galaxies being part of multiply imaged systems, located less than 1 arcsec from brighter foreground galaxies at z ≈ 2. This lens-induced association of high-redshift and foreground galaxies has perhaps already been observed among a sample of galaxy candidates identified at z ≈ 10.6. Future surveys will need to be designed to account for a significant gravitational lensing bias in high-redshift galaxy samples.

  3. Structure formation simulations with momentum exchange: alleviating tensions between high-redshift and low-redshift cosmological probes

    CERN Document Server

    Baldi, Marco

    2016-01-01

    Persisting tensions between the cosmological constraints derived from low-redshift probes and the ones obtained from temperature and polarisation anisotropies of the Cosmic Microwave Background -- although not yet providing compelling evidence against the $\\Lambda $CDM model -- seem to consistently indicate a slower growth of density perturbations as compared to the predictions of the standard cosmological scenario. Such behavior is not easily accommodated by the simplest extensions of General Relativity, such as f(R) models, which generically predict an enhanced growth rate. In the present work we present the outcomes of a suite of large N-body simulations carried out in the context of a cosmological model featuring a non-vanishing scattering cross section between the dark matter and the dark energy fields, for two different parameterisations of the dark energy equation of state. Our results indicate that these Dark Scattering models have very mild effects on many observables related to large-scale structure...

  4. Comparison of HI and optical redshifts of galaxies - The impact of redshift uncertainties on spectral line stacking

    CERN Document Server

    Maddox, Natasha; Blyth, S -L; Jarvis, M J

    2013-01-01

    Accurate optical redshifts will be critical for spectral co-adding techniques used to extract detections from below the noise level in ongoing and upcoming surveys for HI, which will extend our current understanding of gas reservoirs in galaxies to lower column densities and higher redshifts. We have used existing, high quality optical and radio data from the SDSS and ALFALFA surveys to investigate the relationship between redshifts derived from optical spectroscopy and neutral hydrogen (HI) spectral line observations. We find that the two redshift measurements agree well, with a negligible systematic offset and a small distribution width. Employing simple simulations, we determine how the width of an ideal stacked HI profile depends on these redshift offsets, as well as larger redshift errors more appropriate for high redshift galaxy surveys. The width of the stacked profile is dominated by the width distribution of the input individual profiles when the redshift errors are less than the median width of the ...

  5. Photometric selection of high-redshift type Ia supernovae

    CERN Document Server

    Sullivan, M; Perrett, K; Nugent, P; Astier, Pierre; Aubourg, E; Balam, D; Basa, S; Carlberg, R; Conley, A; Fabbro, S; Fouchez, D; Guy, J; Hook, I; Lafoux, H; Neill, J D; Pain, R; Palanque-Delabrouille, Nathalie; Pritchet, C; Regnault, N; Rich, J; Taillet, R; Aldering, G; Baumont, S; Bronder, J; Filiol, M; Knop, R; Perlmutter, S; Tao, C

    2005-01-01

    We present a method for selecting high-redshift type Ia supernovae (SNe Ia) located via rolling SN searches. The technique, using both color and magnitude information of events from only 2-3 epochs of multi-band real-time photometry, is able to discriminate between SNe Ia and core collapse SNe. Furthermore, for the SNe Ia, the method accurately predicts the redshift, phase and light-curve parameterization of these events based only on pre-maximum-light data. We demonstrate the effectiveness of the technique on a simulated survey of SNe Ia and core-collapse SNe, where the selection method effectively rejects most core-collapse SNe while retaining SNe Ia. We also apply the selection code to real-time data acquired as part of the Canada-France-Hawaii Telescope Supernova Legacy Survey (SNLS). During the period May 2004 to January 2005 in the SNLS, 440 SN candidates were discovered of which 70 were confirmed spectroscopically as SNe Ia and 15 as core-collapse events. For this test dataset, the selection technique ...

  6. Strength of family history in predicting levels of blood pressure, plasma glucose and cholesterol.

    Science.gov (United States)

    Wandeler, G; Paccaud, F; Vollenweider, P; Waeber, G; Mooser, V; Bochud, M

    2010-01-01

    Limited information is available on the quantitative relationship between family history and the corresponding underlying traits. We analyzed these associations for blood pressure, fasting blood glucose, and cholesterol levels. Data were obtained from 6,102 Caucasian participants (2,903 men and 3,199 women) aged 35-75 years using a population-based cross-sectional survey in Switzerland. Cardiovascular disease risk factors were measured, and the corresponding family history was self-reported using a structured questionnaire. The prevalence of a positive family history (in first-degree relatives) was 39.6% for hypertension, 22.3% for diabetes, and 29.0% for hypercholesterolemia. Family history was not known for at least one family member in 41.8% of participants for hypertension, 14.4% for diabetes, and 50.2% for hypercholesterolemia. A positive family history was strongly associated with higher levels of the corresponding trait, but not with the other traits. Participants who reported not to know their family history of hypertension had a higher systolic blood pressure than participants with a negative history. Sibling histories had higher positive predictive values than parental histories. The ability to discriminate, calibrate, and reclassify was best for the family history of hypertension. Family history of hypertension, diabetes, and hypercholesterolemia was strongly associated with the corresponding dichotomized and continuous phenotypes. Copyright 2009 S. Karger AG, Basel.

  7. Exploring the SDSS photometric galaxies with clustering redshifts

    Science.gov (United States)

    Rahman, Mubdi; Mendez, Alexander J.; Ménard, Brice; Scranton, Ryan; Schmidt, Samuel J.; Morrison, Christopher B.; Budavári, Tamás

    2016-07-01

    We apply clustering-based redshift inference to all extended sources from the Sloan Digital Sky Survey photometric catalogue, down to magnitude r = 22. We map the relationships between colours and redshift, without assumption of the sources' spectral energy distributions (SEDs). We identify and locate star-forming quiescent galaxies, and active galactic nuclei, as well as colour changes due to spectral features, such as the 4000 Å break, redshifting through specific filters. Our mapping is globally in good agreement with colour-redshift tracks computed with SED templates, but reveals informative differences, such as the need for a lower fraction of M-type stars in certain templates. We compare our clustering-redshift estimates to photometric redshifts and find these two independent estimators to be in good agreement at each limiting magnitude considered. Finally, we present the global clustering-redshift distribution of all Sloan extended sources, showing objects up to z ˜ 0.8. While the overall shape agrees with that inferred from photometric redshifts, the clustering-redshift technique results in a smoother distribution, with no indication of structure in redshift space suggested by the photometric-redshift estimates (likely artefacts imprinted by their spectroscopic training set). We also infer a higher fraction of high-redshift objects. The mapping between the four observed colours and redshift can be used to estimate the redshift probability distribution function of individual galaxies. This work is an initial step towards producing a general mapping between redshift and all available observables in the photometric space, including brightness, size, concentration, and ellipticity.

  8. Plasma oxytocin concentrations and OXTR polymorphisms predict social impairments in children with and without autism spectrum disorder.

    Science.gov (United States)

    Parker, Karen J; Garner, Joseph P; Libove, Robin A; Hyde, Shellie A; Hornbeak, Kirsten B; Carson, Dean S; Liao, Chun-Ping; Phillips, Jennifer M; Hallmayer, Joachim F; Hardan, Antonio Y

    2014-08-19

    The neuropeptide oxytocin (OXT) and its receptor (OXTR) regulate social functioning in animals and humans. Initial clinical research suggests that dysregulated plasma OXT concentrations and/or OXTR SNPs may be biomarkers of social impairments in autism spectrum disorder (ASD). We do not know, however, whether OXT dysregulation is unique to ASD or whether OXT biology influences social functioning more generally, thus contributing to, but not causing, ASD phenotypes. To distinguish between these possibilities, we tested in a child ASD cohort, which included unaffected siblings and unrelated neurotypical controls (ages 3-12 y; n = 193), whether plasma OXT concentrations and OXTR SNPs (i) interact to produce ASD phenotypes, (ii) exert differential phenotypic effects in ASD vs. non-ASD children, or (iii) have similar phenotypic effects independent of disease status. In the largest cohort tested to date, we found no evidence to support the OXT deficit hypothesis of ASD. Rather, OXT concentrations strongly and positively predicted theory of mind and social communication performance in all groups. Furthermore, OXT concentrations showed significant heritability between ASD-discordant siblings (h(2) = 85.5%); a heritability estimate on par with that of height in humans. Finally, carriers of the "G" allele of rs53576 showed impaired affect recognition performance and carriers of the "A" allele of rs2254298 exhibited greater global social impairments in all groups. These findings indicate that OXT biology is not uniquely associated with ASD, but instead exerts independent, additive, and highly heritable influences on individual differences in human social functioning, including the severe social impairments which characterize ASD.

  9. Galactic Synchrotron Emission and the Far-infrared-Radio Correlation at High Redshift

    Science.gov (United States)

    Schober, J.; Schleicher, D. R. G.; Klessen, R. S.

    2016-08-01

    Theoretical scenarios, including the turbulent small-scale dynamo, predict that strong magnetic fields already exist in young galaxies. Based on the assumption of energy equipartition between magnetic fields and turbulence, we determine the galactic synchrotron flux as a function of redshift z. Galaxies in the early universe are different from local galaxies, in particular, the former have more intense star formation. To cover a large range of conditions, we consider two different systems: one model galaxy comparable to the Milky Way and one typical high-z starburst galaxy. We include a model of the steady-state cosmic ray spectrum and find that synchrotron emission can be detected up to cosmological redshifts with current and future radio telescopes. The turbulent dynamo theory is in agreement with the origin of the observed correlation between the far-infrared (FIR) luminosity L FIR and the radio luminosity L radio. Our model reproduces this correlation well at z = 0. We extrapolate the FIR-radio correlation to higher redshifts and predict a time evolution with a significant deviation from its present-day appearance already at z≈ 2 for a gas density that increases strongly with z. In particular, we predict a decrease of the radio luminosity with redshift which is caused by the increase of cosmic ray energy losses at high z. The result is an increase of the ratio between L FIR and L radio. Simultaneously, we predict that the slope of the FIR-radio correlation becomes shallower with redshift. This behavior of the correlation could be observed in the near future with ultra-deep radio surveys.

  10. Plasma osteoprotegerin levels predict cardiovascular and all-cause mortality and deterioration of kidney function in type 1 diabetic patients with nephropathy

    DEFF Research Database (Denmark)

    Jorsal, A.; Tarnow, L.; Flyvbjerg, A.

    2008-01-01

    AIMS/HYPOTHESIS: The bone-related peptide osteoprotegerin is produced by vascular cells and is involved in the process of vascular calcification. The aim of this study was to investigate the predictive value of plasma levels of osteoprotegerin in relation to mortality, cardiovascular events and d...

  11. Measuring a cosmological distance-redshift relationship using only gravitational wave observations of binary neutron star coalescences.

    Science.gov (United States)

    Messenger, C; Read, J

    2012-03-02

    Detection of gravitational waves from the inspiral phase of binary neutron star coalescence will allow us to measure the effects of the tidal coupling in such systems. Tidal effects provide additional contributions to the phase evolution of the gravitational wave signal that break a degeneracy between the system's mass parameters and redshift and thereby allow the simultaneous measurement of both the effective distance and the redshift for individual sources. Using the population of O(10(3)-10(7)) detectable binary neutron star systems predicted for 3rd generation gravitational wave detectors, the luminosity distance-redshift relation can be probed independently of the cosmological distance ladder and independently of electromagnetic observations. We conclude that for a range of representative neutron star equations of state the redshift of such systems can be determined to an accuracy of 8%-40% for z<1 and 9%-65% for 1

  12. Plasma nevirapine concentrations predict virological and adherence failure in Kenyan HIV-1 infected patients with extensive antiretroviral treatment exposure

    Science.gov (United States)

    Kimulwo, Maureen J.; Okendo, Javan; Aman, Rashid A.; Ogutu, Bernhards R.; Kokwaro, Gilbert O.; Ochieng, Dorothy J.; Muigai, Anne W. T.; Oloo, Florence A.

    2017-01-01

    Treatment failure is a key challenge in the management of HIV-1 infection. We conducted a mixed-model survey of plasma nevirapine (NVP) concentrations (cNVP) and viral load in order to examine associations with treatment and adherence outcomes among Kenyan patients on prolonged antiretroviral therapy (ART). Blood plasma was collected at 1, 4 and 24 hours post-ART dosing from 58 subjects receiving NVP-containing ART and used to determine cNVP and viral load (VL). Median duration of treatment was 42 (range, 12–156) months, and 25 (43.1%) of the patients had virologic failure (VF). cNVP was significantly lower for VF than non- VF at 1hr (mean, 2,111ng/ml vs. 3,432ng/ml, p = 0.003) and at 4hr (mean 1,625ng/ml vs. 3,999ng/ml, p = 0.001) but not at 24hr post-ART dosing. Up to 53.4%, 24.1% and 22.4% of the subjects had good, fair and poor adherence respectively. cNVP levels peaked and were > = 3μg.ml at 4 hours in a majority of patients with good adherence and those without VF. Using a threshold of 3μg/ml for optimal therapeutic nevirapine level, 74% (43/58), 65.5% (38/58) and 86% (50/58) of all patients had sub-therapeutic cNVP at 1, 4 and 24 hours respectively. cNVP at 4 hours was associated with adherence (p = 0.05) and virologic VF (p = 0.002) in a chi-square test. These mean cNVP levels differed significantly in non-parametric tests between adherence categories at 1hr (p = 0.005) and 4hrs (p = 0.01) and between ART regimen categories at 1hr (p = 0.004) and 4hrs (p<0.0001). Moreover, cNVP levels correlated inversely with VL (p< = 0.006) and positively with adherence behavior. In multivariate tests, increased early peak NVP (cNVP4) was independently predictive of lower VL (p = 0.002), while delayed high NVP peak (cNVP24) was consistent with increased VL (p = 0.033). These data strongly assert the need to integrate plasma concentrations of NVP and that of other ART drugs into routine ART management of HIV-1 patients. PMID:28235021

  13. The kinematic origin of the cosmological redshift

    CERN Document Server

    Bunn, Emory F

    2008-01-01

    A common belief among cosmologists is that the cosmological redshift cannot be properly viewed as a Doppler shift (that is, as evidence for a recession velocity), but must instead be viewed in terms of the stretching of space. We argue that the most natural interpretation of the redshift is in fact as a Doppler shift, or rather as the accumulation of many infinitesimal Doppler shifts. The stretching-of-space interpretation obscures a central idea of relativity, namely that of coordinate freedom, specifically the idea that it is always valid to choose a coordinate system that is locally Minkowski. We show that, in any spacetime, an observed frequency shift can be interpreted either as a kinematic (Doppler) shift or a gravitational shift by imagining a family of observers along the photon's path. In the context of the expanding Universe, the kinematic interpretation corresponds to a family of comoving observers and hence seems to be the more natural one.

  14. Morphologies at High Redshift from Galaxy Zoo

    Science.gov (United States)

    Masters, Karen; Melvin, Tom; Simmons, Brooke; Willett, Kyle; Lintott, Chris

    2015-08-01

    I will present results from Galaxy Zoo classification of galaxies observed in public observed frame optical HST surveys (e.g. COSMOS, GOODS) as well as in observed frame NIR with (ie. CANDELS). Early science results from these classifications have investigated the changing bar fraction in disc galaxies as a function of redshift (to z~1 in Melvin et al. 2014; and at z>1 in Simmons et al. 2015), as well as how the morphologies of galaxies on the red sequence have been changing since z~1 (Melvin et al. in prep.). These unique dataset of quantitative visual classifications for high redshift galaxies will be made public in forthcoming publications (planned as Willett et al. for Galaxy Zoo Hubble, and Simmons et al. for Galaxy Zoo CANDELS).

  15. Lensing Reconstruction using redshifted 21cm Fluctuations

    CERN Document Server

    Zahn, O; Zahn, Oliver; Zaldarriaga, Matias

    2005-01-01

    We investigate the potential of second generation measurements of redshifted 21 cm radiation from the epoch of reionization (EOR) to reconstruct the matter density fluctuations along the line of sight. To do so we generalize the quadratic methods developed for the Cosmic Microwave Background (CMB) to 21cm fluctuations. The three dimensional signal can be analyzed into a finite number of line of sight Fourier modes that contribute to the lensing reconstruction. In comparison with reconstruction using the CMB, 21cm fluctuations have a disadvantage of relative featurelessness, which can be compensated for by the fact that there are multiple uncorrelated backgrounds. The multiple redshift information allows to reconstruct relatively small scales even if one is limited by angular resolution. We estimate that a square kilometer of collecting area is needed with a maximal baseline of 3 km to achieve lensing reconstruction noise levels an order of magnitude below CMB quadratic estimator constraints at $l=1000$, and c...

  16. Structure of the universe at high redshifts

    CERN Document Server

    Doroshkevich, D

    2002-01-01

    We extend the approximate statistical description of the process of formation and evolution of structure of the universe based on the modified Zel'dovich theory of gravitational instability discussed in our previous paper. We show that, in this approach, the mass distribution of different structure elements -- walls, pancakes, filaments and clouds -- is described by the same time dependent function. In all these cases, the mass of formed structure elements is found to be concentrated near the mean mass. At high redshifts, both the mass function and the mean mass of formed elements depend upon the small scale part of the initial power spectrum and, in particular, upon the mass of dominant fraction of dark matter (DM) particles. These results generalize the Press-Schechter approach and allow also to obtain independent estimates of the probable redshifts of the reionization and reheating periods of the Universe. We show that the transverse motions -- expansion and/or compression -- do not change significantly th...

  17. Atom Interferometers and the Gravitational Redshift

    CERN Document Server

    Sinha, Supurna

    2011-01-01

    Muller, Peters and Chu (MPC) claim that a reinterpretation of decade old experiments with atom interferometers leads to a sensitive test of the gravitational redshift effect. This claim has been disputed by Wolf et al (WBBRSC), who adduce arguments to show that MPC's claim is incorrect. In this Letter, we distill the arguments offered by WBBRSC to a single fundamental objection: an atom is not a clock ticking at the Compton frequency. We show that atom interferometric experiments conducted to date do not test the gravitational redshift effect. Our analysis is general and focuses on points of principle rather thanon the present state of technology. We then observe that it is in principle possible to use atom lasers to produce sensitive tests of the red shift effect at the Compton frequency. Such tests may become technologically realisable in the future.

  18. Gravitational redshift experiment on RadioAstron

    Science.gov (United States)

    Litvinov, Dmitry; Bietenholz, Michael; Rudenko, Valentin; Biriukov, Alexander; Kauts, Vladimir; Kulagin, Victor; Bartel, Norbert; Gwinn, Carl; Cannon, Wayne

    The RadioAstron space radio telescope offers a possibility for testing the gravitational redshift effect with an accuracy of better than 10(-5) , thus, improving the result of the Gravity Probe A mission by at least an order of magnitude. However, RadioAstron’s communications and frequency transfer system doesn’t allow for a direct application of the nonrelativistic Doppler and tropospheric compensation scheme used in the Gravity Probe A experiment. This results in a degradation of the redshift test accuracy to approximately 1%. We discuss two approaches to overcome this difficulty and present preliminary results based on data obtained during special observing sessions scheduled for testing the new techniques.

  19. Photometric Redshift Estimation on SDSS Data Using Random Forests

    CERN Document Server

    Carliles, Samuel; Heinis, Sebastien; Priebe, Carey; Szalay, Alexander

    2007-01-01

    Given multiband photometric data from the SDSS DR6, we estimate galaxy redshifts. We employ a Random Forest trained on color features and spectroscopic redshifts from 80,000 randomly chosen primary galaxies yielding a mapping from color to redshift such that the difference between the estimate and the spectroscopic redshift is small. Our methodology results in tight RMS scatter in the estimates limited by photometric errors. Additionally, this approach yields an error distribution that is nearly Gaussian with parameter estimates giving reliable confidence intervals unique to each galaxy photometric redshift.

  20. High plasma cholesteryl ester transfer but not CETP mass predicts incident cardiovascular disease : A nested case control study

    NARCIS (Netherlands)

    Kappelle, Paul J.W.H.; Perton, Frank; Hillege, Hans L.; Dallinga-Thie, Geesje M.; Dullaart, Robin P. F.

    Objective: The relationship of cardiovascular disease (CVD) with plasma cholesteryl ester transfer protein (CETP) levels is controversial. We determined whether plasma cholesteryl ester transfer (CET), reflecting CETP-mediated transfer of cholesteryl esters from endogenous HDL towards apolipoprotein

  1. Redshift Surveys and the Value of $\\Omega$

    CERN Document Server

    Feldman, H A; Feldman, Hume A.; Melott, Adrian L.

    1999-01-01

    We compare the statistical properties of structures normal and transverse to the line of sight which appear in observational data from redshift surveys. We present a statistic which can quantify this effect in a conceptually different way from standard analyses of distortions of the power-spectrum or correlation function. From tests with N-body experiments, we argue that this statistic represents a new, more direct and potentially powerful diagnostic of the cosmological density parameter Omega.

  2. Redshift-distance relation in inhomogeneous cosmology

    CERN Document Server

    Scharf, Günter

    2015-01-01

    We continue to study a cosmological model with large-scale inhomogeneity. Working in the cosmic rest frame we determine null geodesics, redshift and area and luminosity distance. Combining the result with Hubble's law enables us to calculate the distance of the local group of galaxies from the origin where the Big Bang gas taken place. We obtain a surprisingly small value of about 2 million light years.

  3. Combination of plasma-soluble fms-like tyrosine kinase 1 and uterine artery Doppler for the prediction of preeclampsia in cases of elderly gravida.

    Science.gov (United States)

    Kulmala, Lalita; Phupong, Vorapong

    2014-06-01

    The aim of this study was to determine the predictive value of the combination of plasma-soluble fms-like tyrosine kinase 1 (sFlt-1) and uterine artery Doppler for the detection of preeclampsia in women of advanced age at 16-18 weeks of gestation and to identify associations between other pregnancy complications and abnormalities of these combined tests. The maternal plasma sFlt-1 level was measured, and uterine artery Doppler was performed at 16-18 weeks of gestation in 314 cases of elderly gravida. The main outcome was preeclampsia. Fourteen women (4.46%) developed preeclampsia. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of uterine artery Doppler combined with plasma sFlt-1 for preeclampsia prediction were 28.6, 95.7, 23.5 and 96.6%, respectively. For the prediction of early-onset preeclampsia, the sensitivity, specificity, PPV and NPV were 80, 95.8, 23.5 and 99.7%, respectively. Patients with abnormal uterine artery Doppler findings and an abnormal plasma s Flt-1 level (greater than 1724.5 pg ml(-1)) had a higher risk of preterm delivery (relative risk (RR)=3.38, 95% confidence interval (CI) 1.47-7.59), neonatal respiratory distress syndrome (RR=52.06, 95% CI 5.71-474.45) and perinatal death (RR=17.35, 95% CI 1.13-265.64). Our findings indicate that the combination of uterine artery Doppler and sFlt-1 level at 16-18 weeks of gestation in cases of elderly gravida has a high predictive value for early-onset preeclampsia, but not for overall preeclampsia. This combination test may be a useful early second trimester screening test for the prediction of early-onset preeclampsia in cases of elderly gravida.

  4. The role of plasma triglyceride/high-density lipoprotein cholesterol ratio to predict cardiovascular outcomes in chronic kidney disease.

    Science.gov (United States)

    Sonmez, Alper; Yilmaz, Mahmut Ilker; Saglam, Mutlu; Unal, Hilmi Umut; Gok, Mahmut; Cetinkaya, Hakki; Karaman, Murat; Haymana, Cem; Eyileten, Tayfun; Oguz, Yusuf; Vural, Abdulgaffar; Rizzo, Manfredi; Toth, Peter P

    2015-04-16

    Cardiovascular disease (CVD) risk is substantially increased in subjects with chronic kidney disease (CKD). The Triglycerides (TG) to High-Density Lipoprotein Cholesterol (HDL-C) ratio is an indirect measure of insulin resistance and an independent predictor of cardiovascular risk. No study to date has been performed to evaluate whether the TG/HDL-C ratio predicts CVD risk in patients with CKD. A total of 197 patients (age 53±12 years) with CKD Stages 1 to 5, were enrolled in this longitudinal, observational, retrospective study. TG/HDL-C ratio, HOMA-IR indexes, serum asymmetric dimethyl arginine (ADMA), high sensitivity C-reactive protein (CRP), parathyroid hormone (PTH), calcium, phosphorous, estimated glomerular filtration rate (eGFR), and albumin levels were measured. Flow mediated vasodilatation (FMD) of the brachial artery was assessed by using high-resolution ultrasonography. A total of 11 cardiovascular (CV) deaths and 43 nonfatal CV events were registered in a mean follow-up period of 30 (range 9 to 35) months. Subjects with TG/HDL-C ratios above the median values (>3.29) had significantly higher plasma ADMA, PTH, and phosphorous levels (p=0.04, p=0.02, p=0.01 respectively) and lower eGFR and FMD values (p=0.03, pcardiovascular outcomes [HR: 1.36 (1.11-1.67) (p=0.003)] along with plasma ADMA levels [HR: 1.31 (1.13-1.52) (p<0.001)] and a history of diabetes mellitus [HR: 4.82 (2.80-8.37) (p<0.001)]. This study demonstrates that the elevated TG/HDL-C ratio predicts poor CVD outcome in subjects with CKD. Being a simple, inexpensive, and reproducible marker of CVD risk, the TG/HDL-C ratio may emerge as a novel and reliable indicator among the many well-established markers of CVD risk in CKD. Clinical trial registration number and date: NCT02113462 / 10-04-2014.

  5. MARZ: Manual and Automatic Redshifting Software

    CERN Document Server

    Hinton, Samuel R; Lidman, Chris; Glazebrook, Karl; Lewis, Geraint F

    2016-01-01

    The Australian Dark Energy Survey (OzDES) is a 100-night spectroscopic survey underway on the Anglo-Australian Telescope using the fibre-fed 2-degree-field (2dF) spectrograph. We have developed a new redshifting application Marz with greater usability, flexibility, and the capacity to analyse a wider range of object types than the Runz software package previously used for redshifting spectra from 2dF. Marz is an open-source, client-based, Javascript web-application which provides an intuitive interface and powerful automatic matching capabilities on spectra generated from the AAOmega spectrograph to produce high quality spectroscopic redshift measurements. The software can be run interactively or via the command line, and is easily adaptable to other instruments and pipelines if conforming to the current FITS file standard is not possible. Behind the scenes, a modified version of the Autoz cross-correlation algorithm is used to match input spectra against a variety of stellar and galaxy templates, and automat...

  6. The CNOC2 Field Galaxy Redshift Survey

    CERN Document Server

    Carlberg, R G; Morris, S L; Lin, H; Sawicki, M; Wirth, G; Patton, D; Shepherd, C W; Ellingson, E; Schade, D J; Pritchet, C J; Hartwick, F D A

    1998-01-01

    The CNOC2 field galaxy redshift survey is designed to provide measurements of the evolution of galaxies and their clustering over the redshift range 0 to 0.7. The sample is spread over four sky patches with a total area of about 1.5 square degrees. Here we report preliminary results based on two of the sky patches, and the redshift range of 0.15 to 0.55. We find that galaxy evolution can be statistically described as nearly pure luminosity evolution of early and intermediate SED types, and nearly pure density evolution of the late SED types. The correlation of blue galaxies relative to red galaxies is similar on large scales but drops by a factor of three on scales less than about 0.3/h mpc, approximately the mean scale of virialization. There is a clear, but small, 60%, change in clustering with 1.4 mag of luminosity. To minimize these population effects in our measurement of clustering evolution, we choose galaxies with M_r^{k,e}<= -20 mag as a population whose members are most likely to be conserved wit...

  7. Galaxy Clustering in Early SDSS Redshift Data

    CERN Document Server

    Zehavi, I.; Frieman, Joshua A.; Weinberg, David H.; Mo, Houjun J.; Anderson, Scott F.; Strauss, Michael A.; Annis, James; Bahcall, Neta A.; Bernardi, Mariangela; Briggs, John W.; Brinkmann, Jon; Burles, Scott; Carey, Larry; Castander, Francisco J.; Connolly, J.; Csabai, Istvan; Dalcanton, Julianne J.; Dodelson,Scott; Doi,Mamoru; Eisenstein, Daniel; Evans, Michael L.; Finkbeiner, Douglas P.; Friedman, Scott; Fukugita, Masataka; Gunn, James E.; Hennessy, Greg S.; Hindsley, Robert B.; Ivezic, Zeljko; Kent,Stephen; Knapp, Gillian R.; Kron, Richard; Kunszt, Peter; Lamb, Donald; French Leger, R.; Long, Daniel C.; Loveday, Jon.; Lupton, Robert H.; McKay, Timothy; Meiksin, Avery; Merrelli, Aronne; Munn, Jeffrey A.; Narayanan, Vijay; Newcomb, Matt; Nichol, Robert C.; Owen, Russell; Peoples, John; Pope, Adrian; Rockosi, Constance M.; Schlegel, David; Schneider, Donald P.; Scoccimarro, Roman; Sheth, Ravi K.; Siegmund, Walter; Smee, Stephen; Snir, Yehuda; Stebbins, Albert; Stoughton, Christopher; SubbaRao, Mark; Szalay, Alexander S.; Szapudi, Istvan; Tegmark, Max; Tucker, Douglas L.; Uomoto, Alan; Vanden Berk, Dan; Vogeley, Michael S.; Waddell,Patrick; Yanny, Brian; York, Donald G.; Zehavi, Idit; Blanton, Michael R.; Frieman, Joshua A.; Weinberg, David H.; Mo, Houjun J.; Strauss, Michael A.

    2002-01-01

    We present the first measurements of clustering in the Sloan Digital Sky Survey (SDSS) galaxy redshift survey. Our sample consists of 29,300 galaxies with redshifts 5,700 km/s < cz < 39,000 km/s, distributed in several long but narrow (2.5-5 degree) segments, covering 690 square degrees. For the full, flux-limited sample, the redshift-space correlation length is approximately 8 Mpc/h. The two-dimensional correlation function \\xi(r_p,\\pi) shows clear signatures of both the small-scale, ``fingers-of-God'' distortion caused by velocity dispersions in collapsed objects and the large-scale compression caused by coherent flows, though the latter cannot be measured with high precision in the present sample. The inferred real-space correlation function is well described by a power law, \\xi(r)=(r/6.1+/-0.2 Mpc/h)^{-1.75+/-0.03}, for 0.1 Mpc/h < r < 16 Mpc/h. The galaxy pairwise velocity dispersion is \\sigma_{12} ~ 600+/-100 km/s for projected separations 0.15 Mpc/h < r_p < 5 Mpc/h. When we divide the...

  8. Galaxies at High Redshift and Reionization

    CERN Document Server

    Bunker, Andrew; Ellis, Richard; Lacy, Mark; McMahon, Richard; Eyles, Laurence; Stark, Daniel; Chiu, Kuenley

    2009-01-01

    The quest to discover the most distant galaxies has developed rapidly in the last decade. We are now exploring redshifts of 6 and beyond, when the Universe was less than a billion years old, an epoch when the previously-neutral intergalactic medium was reionized. The continuing discovery of galaxies at progressively higher and higher redshifts has been driven by the availability of large telescopes on the ground and in space, improvements in detector technology, and new search strategies. Over the past 4 years, the Lyman break technique has been shown to be effective in isolating z~6 star-forming i'-drop galaxies through spectroscopic confirmation with large ground-based telescopes (Keck, Gemini and the ESO VLTs). Narrow-band imaging, notably with the wide field of the Subaru telescope, has also produced samples of Lyman-alpha emitters at these redshifts. A The discovery of this i'-drop galaxy population has been used to infer the global star formation rate density at this epoch (z~6), and we are now beginnin...

  9. Clustering-based redshift estimation: application to VIPERS/CFHTLS

    CERN Document Server

    Scottez, V; Granett, B R; Moutard, T; Kilbinger, M; Scodeggio, M; Garilli, B; Bolzonella, M; de la Torre, S; Guzzo, L; Abbas, U; Adami, C; Arnouts, S; Bottini, D; Branchini, E; Cappi, A; Cucciati, O; Davidzon, I; Fritz, A; Franzetti, P; Iovino, A; Krywult, J; Brun, V Le; Fèvre, O Le; Maccagni, D; Małek, K; Marulli, F; Polletta, M; Pollo, A; Tasca, L A M; Tojeiro, R; Vergani, D; Zanichelli, A; Bel, J; Coupon, J; De Lucia, G; Ilbert, O; McCracken, H J; Moscardini, L

    2016-01-01

    We explore the accuracy of the clustering-based redshift estimation proposed by M\\'enard et al. (2013) when applied to VIPERS and CFHTLS real data. This method enables us to reconstruct redshift distributions from measurement of the angular clus- tering of objects using a set of secure spectroscopic redshifts. We use state of the art spectroscopic measurements with iAB 0.5 which allows us to test the accuracy of the clustering-based red- shift distributions. We show that this method enables us to reproduce the true mean color-redshift relation when both populations have the same magnitude limit. We also show that this technique allows the inference of redshift distributions for a population fainter than the one of reference and we give an estimate of the color-redshift mapping in this case. This last point is of great interest for future large redshift surveys which suffer from the need of a complete faint spectroscopic sample.

  10. Exploring the SDSS Photometric Galaxies with Clustering Redshifts

    CERN Document Server

    Rahman, Mubdi; Ménard, Brice; Scranton, Ryan; Schmidt, Samuel J; Morrison, Christopher B; Budavári, Tamás

    2015-01-01

    We apply clustering-based redshift inference to all extended sources from the Sloan Digital Sky Survey photometric catalogue, down to magnitude r = 22. We map the relationships between colours and redshift, without assumption of the sources' spectral energy distributions (SED). We identify and locate star-forming, quiescent galaxies, and AGN, as well as colour changes due to spectral features, such as the 4000 \\AA{} break, redshifting through specific filters. Our mapping is globally in good agreement with colour-redshift tracks computed with SED templates, but reveals informative differences, such as the need for a lower fraction of M-type stars in certain templates. We compare our clustering-redshift estimates to photometric redshifts and find these two independent estimators to be in good agreement at each limiting magnitude considered. Finally, we present the global clustering-redshift distribution of all Sloan extended sources, showing objects up to z ~ 0.8. While the overall shape agrees with that infer...

  11. New insights on the accuracy of photometric redshift measurements

    CERN Document Server

    Massarotti, M; Buzzoni, A; Valls-Gabaud, D

    2001-01-01

    We use the deepest and most complete redshift catalog currently available (the Hubble Deep Field (HDF) North supplemented by new HDF South redshift data) to minimize residuals between photometric and spectroscopic redshift estimates. The good agreement at z_spec 2.0, the systematic shift between photometric and spectroscopic redshifts decreases when the modeling of the absorption by the interstellar and intergalactic media is refined. As a result, in the entire redshift range 0 < z < 6, residuals between photometric and spectroscopic redshifts are roughly halved. For objects fainter than the spectroscopic limit, the main source of uncertainty in photometric redshifts is related to photometric errors, and can be assessed with Monte Carlo simulations.

  12. MAPPING THE GALAXY COLOR–REDSHIFT RELATION: OPTIMAL PHOTOMETRIC REDSHIFT CALIBRATION STRATEGIES FOR COSMOLOGY SURVEYS

    Energy Technology Data Exchange (ETDEWEB)

    Masters, Daniel; Steinhardt, Charles; Faisst, Andreas [Infrared Processing and Analysis Center, California Institute of Technology, Pasadena, CA 91125 (United States); Capak, Peter [Spitzer Science Center, California Institute of Technology, Pasadena, CA 91125 (United States); Stern, Daniel; Rhodes, Jason [Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA 91109 (United States); Ilbert, Olivier [Aix Marseille Universite, CNRS, LAM (Laboratoire dAstrophysique de Marseille) UMR 7326, F-13388, Marseille (France); Salvato, Mara [Max-Planck-Institut für extraterrestrische Physik, Giessenbachstrasse, D-85748 Garching (Germany); Schmidt, Samuel [Department of Physics, University of California, Davis, CA 95616 (United States); Longo, Giuseppe [Department of Physics, University Federico II, via Cinthia 6, I-80126 Napoli (Italy); Paltani, Stephane; Coupon, Jean [Department of Astronomy, University of Geneva ch. dcogia 16, CH-1290 Versoix (Switzerland); Mobasher, Bahram [Department of Physics and Astronomy, University of California, Riverside, CA 92521 (United States); Hoekstra, Henk [Leiden Observatory, Leiden University, P.O. Box 9513, 2300 RA, Leiden (Netherlands); Hildebrandt, Hendrik [Argelander-Institut für Astronomie, Universität Bonn, Auf dem H’´ugel 71, D-53121 Bonn (Germany); Speagle, Josh [Department of Astronomy, Harvard University, 60 Garden Street, MS 46, Cambridge, MA 02138 (United States); Kalinich, Adam [Massachusetts Institute of Technology, Cambridge, MA 02139 (United States); Brodwin, Mark [Department of Physics and Astronomy, University of Missouri, Kansas City, MO 64110 (United States); Brescia, Massimo; Cavuoti, Stefano [Astronomical Observatory of Capodimonte—INAF, via Moiariello 16, I-80131, Napoli (Italy)

    2015-11-01

    Calibrating the photometric redshifts of ≳10{sup 9} galaxies for upcoming weak lensing cosmology experiments is a major challenge for the astrophysics community. The path to obtaining the required spectroscopic redshifts for training and calibration is daunting, given the anticipated depths of the surveys and the difficulty in obtaining secure redshifts for some faint galaxy populations. Here we present an analysis of the problem based on the self-organizing map, a method of mapping the distribution of data in a high-dimensional space and projecting it onto a lower-dimensional representation. We apply this method to existing photometric data from the COSMOS survey selected to approximate the anticipated Euclid weak lensing sample, enabling us to robustly map the empirical distribution of galaxies in the multidimensional color space defined by the expected Euclid filters. Mapping this multicolor distribution lets us determine where—in galaxy color space—redshifts from current spectroscopic surveys exist and where they are systematically missing. Crucially, the method lets us determine whether a spectroscopic training sample is representative of the full photometric space occupied by the galaxies in a survey. We explore optimal sampling techniques and estimate the additional spectroscopy needed to map out the color–redshift relation, finding that sampling the galaxy distribution in color space in a systematic way can efficiently meet the calibration requirements. While the analysis presented here focuses on the Euclid survey, similar analysis can be applied to other surveys facing the same calibration challenge, such as DES, LSST, and WFIRST.

  13. A new method to search for high redshift clusters using photometric redshifts

    CERN Document Server

    Castignani, Gianluca; Celotti, Annalisa; Norman, Colin

    2014-01-01

    We describe a new method (Poisson Probability Method, PPM) to search for high redshift galaxy clusters and groups by using photometric redshift information and galaxy number counts. The method relies on Poisson statistics and is primarily introduced to search for Mpc-scale environments around a specific beacon. The PPM is tailored to both the properties of the FR I radio galaxies in the Chiaberge et al. (2009) sample, that are selected within the COSMOS survey, and on the specific dataset used. We test the efficiency of our method of searching for cluster candidates against simulations. Two different approaches are adopted. i) We use two z~1 X-ray detected cluster candidates found in the COSMOS survey and we shift them to higher redshift up to z=2. We find that the PPM detects the cluster candidates up to z=1.5, and it correctly estimates both the redshift and size of the two clusters. ii) We simulate spherically symmetric clusters of different size and richness, and we locate them at different redshifts (i.e...

  14. Galaxy Mergers and Dark Matter Halo Mergers in LCDM: Mass, Redshift, and Mass-Ratio Dependence

    CERN Document Server

    Stewart, Kyle R; Barton, Elizabeth J; Wechsler, Risa H

    2008-01-01

    We employ a high-resolution LCDM N-body simulation to present merger rate predictions for dark matter halos and investigate how common merger-related observables for galaxies--such as close pair counts, starburst counts, and the morphologically disturbed fraction--likely scale with luminosity, stellar mass, merger mass ratio, and redshift from z=0 to z=4. We provide a simple 'universal' fitting formula that describes our derived merger rates for dark matter halos a function of dark halo mass, merger mass ratio, and redshift, and go on to predict galaxy merger rates using number density-matching to associate halos with galaxies. For example, we find that the instantaneous merger rate of m/M>0.3 mass ratio events into typical L > f L* galaxies follows the simple relation dN/dt=0.03(1+f)(1+z)^2.1 Gyr^-1. Despite the rapid increase in merger rate with redshift, only a small fraction of >0.4 L* high-redshift galaxies (~3% at z=2) should have experienced a major merger (m/M >0.3) in the very recent past (t0.3) in t...

  15. Peculiar velocities in redshift space: formalism, N-body simulations and perturbation theory

    CERN Document Server

    Okumura, Teppei; Vlah, Zvonimir; Desjacques, Vincent

    2013-01-01

    Direct measurements of peculiar velocities of galaxies and clusters of galaxies can in principle provide explicit information on the three dimensional mass distribution, but this information is modulated by the fact that velocity field is sampled at galaxy positions, and is thus probing galaxy momentum. We derive expressions for the cross power spectrum between the density and momentum field and the auto spectrum of the momentum field in redshift space, by extending the distribution function method to these statistics. The resulting momentum cross and auto power spectra in redshift space are expressed as infinite sums over velocity moment correlators in real space, as is the case for the density power spectrum in redshift space. We compare the predictions of the velocity statistics to those measured from N-body simulations for both dark matter and halos. We find that in redshift space linear theory predictions for the density-momentum cross power spectrum as well as for the momentum auto spectrum fail to pred...

  16. Fasting plasma glucose and hemoglobin A1c in identifying and predicting diabetes: the strong heart study.

    Science.gov (United States)

    Wang, Wenyu; Lee, Elisa T; Howard, Barbara V; Fabsitz, Richard R; Devereux, Richard B; Welty, Thomas K

    2011-02-01

    To compare fasting plasma glucose (FPG) and HbA(1c) in identifying and predicting type 2 diabetes in a population with high rates of diabetes. Diabetes was defined as an FPG level ≥ 126 mg/dL or an HbA(1c) level ≥ 6.5%. Data collected from the baseline and second exams (1989-1995) of the Strong Heart Study were used. RESULTS For cases of diabetes identified by FPG ≥ 126 mg/dL, using HbA(1c) ≥ 6.5% at the initial and 4-year follow-up diabetes screenings (or in identifying incident cases in 4 years) among undiagnosed participants left 46% and 59% of cases of diabetes undetected, respectively, whereas for cases identified by HbA(1c) ≥ 6.5%, using FPG ≥ 126 mg/dL left 11% and 59% unidentified, respectively. Age, waist circumference, urinary albumin-to-creatinine ratio, and baseline FPG and HbA(1c) levels were common significant risk factors for incident diabetes defined by either FPG or HbA(1c); triglyceride levels were significant for diabetes defined by HbA(1c) alone, and blood pressure and sibling history of diabetes were significant for diabetes defined by FPG alone. Using both the baseline FPG and HbA(1c) in diabetes prediction identified more people at risk than using either measure alone. CONCLUSIONS Among undiagnosed participants, using HbA(1c) alone in initial diabetes screening identifies fewer cases of diabetes than FPG, and using either FPG or HbA(1c) alone cannot effectively identify diabetes in a 4-year periodic successive diabetes screening or incident cases of diabetes in 4 years. Using both criteria may identify more people at risk. The proposed models using the commonly available clinical measures can be applied to assessing the risk of incident diabetes using either criterion.

  17. Equivalence-principle Analog of the Gravitational Redshift

    CERN Document Server

    Arms, K

    2016-01-01

    What happens when two synchronized clocks on a rigid beam are both given the exact same acceleration profile? Will they remain synchronized? What if we use a rigid-rod Rindler acceleration profile? The special relativity prediction surprises many people. This experimental setup is the special-relativity analog of the gravitational redshift. Just like two clocks higher and lower in a gravitational field lose synchronization, one sees a loss of synchronization in these clocks with `identical' acceleration profiles. To the best of our knowledge this equivalence principle analog has never been directly measured, and current experimental techniques are sensitive enough to measure it. We discuss the origin of the essential physics behind this synchronization loss, and some special conditions which simplify its experimental observation. We discuss the origin of the essential physics behind this synchronization loss, and some special conditions which simplify its experimental observation. If validated this effect wil...

  18. Disk galaxy formation and evolution models up to intermediate redshifts

    CERN Document Server

    Firmani, C

    1999-01-01

    Making use of a seminumerical method we develop a scenario of disk galaxy formation and evolution in the framework of inflationary cold dark matter (CDM) cosmologies. Within the virializing dark matter halos, disks in centrifugal equilibrium are built-up and their galactic evolution is followed through an approach which considers the gravitational interactions among the galaxy components, the turbulence and energy balance of the ISM, the star formation (SF) process due to disk gravitational instabilities, the stellar evolution and the secular formation of a bulge. We find that the main properties and correlations of disk galaxies are determined by the mass, the hierarchical mass aggregation history and the primordial angular momentum. The models follow the same trends across the Hubble sequence than the observed galaxies. The predicted TF relation is in good agreement with the observations except for the standart CDM. While the slope of this relation remains almost constant up to intermediate redshifts, its z...

  19. Prediction of plasma-induced damage distribution during silicon nitride etching using advanced three-dimensional voxel model

    Energy Technology Data Exchange (ETDEWEB)

    Kuboi, Nobuyuki, E-mail: Nobuyuki.Kuboi@jp.sony.com; Tatsumi, Tetsuya; Kinoshita, Takashi; Shigetoshi, Takushi; Fukasawa, Masanaga; Komachi, Jun; Ansai, Hisahiro [Device and Material Research Group, RDS Platform, Sony Corporation, 4-14-1 Asahi-cho, Atsugi, Kanagawa 243-0014 (Japan)

    2015-11-15

    The authors modeled SiN film etching with hydrofluorocarbon (CH{sub x}F{sub y}/Ar/O{sub 2}) plasma considering physical (ion bombardment) and chemical reactions in detail, including the reactivity of radicals (C, F, O, N, and H), the area ratio of Si dangling bonds, the outflux of N and H, the dependence of the H/N ratio on the polymer layer, and generation of by-products (HCN, C{sub 2}N{sub 2}, NH, HF, OH, and CH, in addition to CO, CF{sub 2}, SiF{sub 2}, and SiF{sub 4}) as ion assistance process parameters for the first time. The model was consistent with the measured C-F polymer layer thickness, etch rate, and selectivity dependence on process variation for SiN, SiO{sub 2}, and Si film etching. To analyze the three-dimensional (3D) damage distribution affected by the etched profile, the authors developed an advanced 3D voxel model that can predict the time-evolution of the etched profile and damage distribution. The model includes some new concepts for gas transportation in the pattern using a fluid model and the property of voxels called “smart voxels,” which contain details of the history of the etching situation. Using this 3D model, the authors demonstrated metal–oxide–semiconductor field-effect transistor SiN side-wall etching that consisted of the main-etch step with CF{sub 4}/Ar/O{sub 2} plasma and an over-etch step with CH{sub 3}F/Ar/O{sub 2} plasma under the assumption of a realistic process and pattern size. A large amount of Si damage induced by irradiated hydrogen occurred in the source/drain region, a Si recess depth of 5 nm was generated, and the dislocated Si was distributed in a 10 nm deeper region than the Si recess, which was consistent with experimental data for a capacitively coupled plasma. An especially large amount of Si damage was also found at the bottom edge region of the metal–oxide–semiconductor field-effect transistors. Furthermore, our simulation results for bulk fin-type field-effect transistor side-wall etching

  20. Prediction and optimization of process variables to maximize the Young's modulus of plasma sprayed alumina coatings on AZ31B magnesium alloy

    Directory of Open Access Journals (Sweden)

    D. Thirumalaikumarasamy

    2017-03-01

    Full Text Available Like other manufacturing techniques, plasma spraying has also a non-linear behavior because of the contribution of many coating variables. This characteristic results in finding optimal factor combination difficult. Subsequently, the issue can be solved through effective and strategic statistical procedures integrated with systematic experimental data. Plasma spray parameters such as power, stand-off distance and powder feed rate have significant influence on coating characteristics like Young's modulus. This paper presents the use of statistical techniques in specifically response surface methodology (RSM, analysis of variance, and regression analysis to develop empirical relationship to predict Young's modulus of plasma-sprayed alumina coatings. The developed empirical relationships can be effectively used to predict Young's modulus of plasma-sprayed alumina coatings at 95% confidence level. Response graphs and contour plots were constructed to identify the optimum plasma spray parameters to attain maximum Young's modulus in alumina coatings. A linear regression relationship was established between porosity and Young's modulus of the alumina coatings.

  1. The relation between mass and concentration in X-ray galaxy clusters at high redshift

    Science.gov (United States)

    Amodeo, S.; Ettori, S.; Capasso, R.; Sereno, M.

    2016-05-01

    Context. Galaxy clusters are the most recent, gravitationally bound products of the hierarchical mass accretion over cosmological scales. How the mass is concentrated is predicted to correlate with the total mass in the halo of the cluster, wherein systems at higher mass are less concentrated at given redshift and, for any given mass, systems with lower concentration are found at higher redshifts. Aims: Through a spatial and spectral X-ray analysis, we reconstruct the total mass profile of 47 galaxy clusters observed with Chandra in the redshift range 0.4 0.4, and is well suited to providing the first constraint on the concentration-mass relation at z> 0.7 from X-ray analysis. Methods: Under the assumption that the distribution of the X-ray emitting gas is spherically symmetric and in the hydrostatic equilibrium with the underlined gravitational potential, we combine the deprojected gas density and spectral temperature profiles through the hydrostatic equilibrium equation to recover the parameters that describe a Navarro-Frenk-White total mass distribution. The comparison with results from weak-lensing analysis reveals a very good agreement both for masses and concentrations. The uncertainties are however too large to make any robust conclusion about the hydrostatic bias of these systems. Results: The distribution of concentrations is well approximated by a log-normal function in all the mass and redshift ranges investigated. The relation is well described by the form c ∝ MB(1 + z)C with B = -0.50 ± 0.20, C = 0.12 ± 0.61 (at 68.3% confidence). This relation is slightly steeper than that predicted by numerical simulations (B ~ -0.1) and does not show any evident redshift evolution. We obtain the first constraints on the properties of the concentration-mass relation at z> 0.7 from X-ray data, showing a reasonable good agreement with recent numerical predictions.

  2. GPZ: non-stationary sparse Gaussian processes for heteroscedastic uncertainty estimation in photometric redshifts

    Science.gov (United States)

    Almosallam, Ibrahim A.; Jarvis, Matt J.; Roberts, Stephen J.

    2016-10-01

    The next generation of cosmology experiments will be required to use photometric redshifts rather than spectroscopic redshifts. Obtaining accurate and well-characterized photometric redshift distributions is therefore critical for Euclid, the Large Synoptic Survey Telescope and the Square Kilometre Array. However, determining accurate variance predictions alongside single point estimates is crucial, as they can be used to optimize the sample of galaxies for the specific experiment (e.g. weak lensing, baryon acoustic oscillations, supernovae), trading off between completeness and reliability in the galaxy sample. The various sources of uncertainty in measurements of the photometry and redshifts put a lower bound on the accuracy that any model can hope to achieve. The intrinsic uncertainty associated with estimates is often non-uniform and input-dependent, commonly known in statistics as heteroscedastic noise. However, existing approaches are susceptible to outliers and do not take into account variance induced by non-uniform data density and in most cases require manual tuning of many parameters. In this paper, we present a Bayesian machine learning approach that jointly optimizes the model with respect to both the predictive mean and variance we refer to as Gaussian processes for photometric redshifts (GPZ). The predictive variance of the model takes into account both the variance due to data density and photometric noise. Using the Sloan Digital Sky Survey (SDSS) DR12 data, we show that our approach substantially outperforms other machine learning methods for photo-z estimation and their associated variance, such as TPZ and ANNZ2. We provide a MATLAB and PYTHON implementations that are available to download at https://github.com/OxfordML/GPz.

  3. 2-h postchallenge plasma glucose predicts cardiovascular events in patients with myocardial infarction without known diabetes mellitus

    Directory of Open Access Journals (Sweden)

    Henareh Loghman

    2012-08-01

    Full Text Available Abstract Background and purpose The incidence of cardiovascular events remains high in patients with myocardial infarction (MI despite advances in current therapies. New and better methods for identifying patients at high risk of recurrent cardiovascular (CV events are needed. This study aimed to analyze the predictive value of an oral glucose tolerance test (OGTT in patients with acute myocardial infarction without known diabetes mellitus (DM. Methods The prospective cohort study consisted of 123 men and women aged between 31–80 years who had suffered a previous MI 3–12 months before the examinations. The exclusion criteria were known diabetes mellitus. Patients were followed up over 6.03 ± 1.36 years for CV death, recurrent MI, stroke and unstable angina pectoris. A standard OGTT was performed at baseline. Results 2-h plasma glucose (HR, 1.27, 95% CI, 1.00 to 1.62; P  Conclusions In this study population, with previous MI and without known DM, 2-h PG and smoking were significant predictors of CV death, recurrent MI, stroke and unstable angina pectoris, independent of baseline characteristics and medical treatment.

  4. Damage prediction of carbon fibre composite armoured actively cooled plasma-facing components under cycling heat loads

    Energy Technology Data Exchange (ETDEWEB)

    Chevet, G; Schlosser, J; Courtois, X; Escourbiac, F; Missirlian, M [CEA, IRFM, F-13108 Saint Paul Lez Durance (France); Herb, V; Martin, E; Camus, G [LCTS, CNRS UMR 5801, Universite Bordeaux 1, Pessac (France); Braccini, M [SIMaP, CNRS UMR 5266, Grenoble (France)], E-mail: gaelle.chevet@cea.fr

    2009-12-15

    In order to predict the lifetime of carbon fibre composite (CFC) armoured plasma-facing components in magnetic fusion devices, it is necessary to analyse the damage mechanisms and to model the damage propagation under cycling heat loads. At Tore Supra studies have been launched to better understand the damage process of the armoured flat tile elements of the actively cooled toroidal pump limiter, leading to the characterization of the damageable mechanical behaviour of the used N11 CFC material and of the CFC/Cu bond. Up until now the calculations have shown damage developing in the CFC (within the zone submitted to high shear stress) and in the bond (from the free edge of the CFC/Cu interface). Damage is due to manufacturing shear stresses and does not evolve under heat due to stress relaxation. For the ITER divertor, NB31 material has been characterized and the characterization of NB41 is in progress. Finite element calculations show again the development of CFC damage in the high shear stress zones after manufacturing. Stresses also decrease under heat flux so the damage does not evolve. The characterization of the CFC/Cu bond is more complex due to the monoblock geometry, which leads to more scattered stresses. These calculations allow the fabrication difficulties to be better understood and will help to analyse future high heat flux tests on various mock-ups.

  5. High redshift galaxies in the ALHAMBRA survey: I. selection method and number counts based on redshift PDFs

    CERN Document Server

    Viironen, K; López-Sanjuan, C; Varela, J; Chaves-Montero, J; Cristóbal-Hornillos, D; Molino, A; Fernández-Soto, A; Ascaso, B; Cenarro, A J; Cerviño, M; Cepa, J; Ederoclite, A; Márquez, I; Masegosa, J; Moles, M; Oteo, I; Pović, M; Aguerri, J A L; Alfaro, E; Aparicio-Villegas, T; Benítez, N; Broadhurst, T; Cabrera-Caño, J; Castander, J F; Del Olmo, A; Delgado, R M González; Husillos, C; Infante, L; Martínez, V J; Perea, J; Prada, F; Quintana, J M

    2015-01-01

    Context. Most observational results on the high redshift restframe UV-bright galaxies are based on samples pinpointed using the so called dropout technique or Ly-alpha selection. However, the availability of multifilter data allows now replacing the dropout selections by direct methods based on photometric redshifts. In this paper we present the methodology to select and study the population of high redshift galaxies in the ALHAMBRA survey data. Aims. Our aim is to develop a less biased methodology than the traditional dropout technique to study the high redshift galaxies in ALHAMBRA and other multifilter data. Thanks to the wide area ALHAMBRA covers, we especially aim at contributing in the study of the brightest, less frequent, high redshift galaxies. Methods. The methodology is based on redshift probability distribution functions (zPDFs). It is shown how a clean galaxy sample can be obtained by selecting the galaxies with high integrated probability of being within a given redshift interval. However, reach...

  6. The DEEP2 Galaxy Redshift Survey: Design, Observations, Data Reduction, and Redshifts

    Science.gov (United States)

    Newman, Jeffrey A.; Cooper, Michael C.; Davis, Marc; Faber, S. M.; Coil, Alison L.; Guhathakurta, Puragra; Koo, David C.; Phillips, Andrew C.; Conroy, Charlie; Dutton, Aaron A.; Finkbeiner, Douglas P.; Gerke, Brian F.; Rosario, David J.; Weiner, Benjamin J.; Willmer, C. N. A.; Yan, Renbin; Harker, Justin J.; Kassin, Susan A.; Konidaris, N. P.; Lai, Kamson; Madgwick, Darren S.; Noeske, K. G.; Wirth, Gregory D.; Connolly, A. J.; Kaiser, N.; Kirby, Evan N.; Lemaux, Brian C.; Lin, Lihwai; Lotz, Jennifer M.; Luppino, G. A.; Marinoni, C.; Matthews, Daniel J.; Metevier, Anne; Schiavon, Ricardo P.

    2013-09-01

    We describe the design and data analysis of the DEEP2 Galaxy Redshift Survey, the densest and largest high-precision redshift survey of galaxies at z ~ 1 completed to date. The survey was designed to conduct a comprehensive census of massive galaxies, their properties, environments, and large-scale structure down to absolute magnitude MB = -20 at z ~ 1 via ~90 nights of observation on the Keck telescope. The survey covers an area of 2.8 deg2 divided into four separate fields observed to a limiting apparent magnitude of R AB = 24.1. Objects with z 0.7 to be targeted ~2.5 times more efficiently than in a purely magnitude-limited sample. Approximately 60% of eligible targets are chosen for spectroscopy, yielding nearly 53,000 spectra and more than 38,000 reliable redshift measurements. Most of the targets that fail to yield secure redshifts are blue objects that lie beyond z ~ 1.45, where the [O II] 3727 Å doublet lies in the infrared. The DEIMOS 1200 line mm-1 grating used for the survey delivers high spectral resolution (R ~ 6000), accurate and secure redshifts, and unique internal kinematic information. Extensive ancillary data are available in the DEEP2 fields, particularly in the Extended Groth Strip, which has evolved into one of the richest multiwavelength regions on the sky. This paper is intended as a handbook for users of the DEEP2 Data Release 4, which includes all DEEP2 spectra and redshifts, as well as for the DEEP2 DEIMOS data reduction pipelines. Extensive details are provided on object selection, mask design, biases in target selection and redshift measurements, the spec2d two-dimensional data-reduction pipeline, the spec1d automated redshift pipeline, and the zspec visual redshift verification process, along with examples of instrumental signatures or other artifacts that in some cases remain after data reduction. Redshift errors and catastrophic failure rates are assessed through more than 2000 objects with duplicate observations. Sky subtraction is

  7. THE DEEP2 GALAXY REDSHIFT SURVEY: DESIGN, OBSERVATIONS, DATA REDUCTION, AND REDSHIFTS

    Energy Technology Data Exchange (ETDEWEB)

    Newman, Jeffrey A. [Department of Physics and Astronomy, University of Pittsburgh, Pittsburgh, PA 15260 (United States); Cooper, Michael C. [Center for Galaxy Evolution, Department of Physics and Astronomy, University of California, Irvine, 4129 Frederick Reines Hall, Irvine, CA 92697 (United States); Davis, Marc [Department of Astronomy and Physics, University of California, 601 Campbell Hall, Berkeley, CA 94720 (United States); Faber, S. M.; Guhathakurta, Puragra; Koo, David C.; Phillips, Andrew C.; Conroy, Charlie; Harker, Justin J.; Lai, Kamson [UCO/Lick Observatory, University of California, 1156 High Street, Santa Cruz, CA 95064 (United States); Coil, Alison L. [Department of Physics, University of California, San Diego, La Jolla, CA 92093 (United States); Dutton, Aaron A. [Max Planck Institute for Astronomy, Koenigstuhl 17, D-69117 Heidelberg (Germany); Finkbeiner, Douglas P. [Harvard-Smithsonian Center for Astrophysics, Harvard University, 60 Garden St., Cambridge, MA 02138 (United States); Gerke, Brian F. [Lawrence Berkeley National Laboratory, 1 Cyclotron Rd., MS 90R4000, Berkeley, CA 94720 (United States); Rosario, David J. [Max-Planck-Institut fuer Extraterrestrische Physik, Giessenbachstrasse, D-85748 Garching (Germany); Weiner, Benjamin J.; Willmer, C. N. A. [Steward Observatory, University of Arizona, 933 N. Cherry Ave., Tucson, AZ 85721-0065 (United States); Yan Renbin [Department of Physics and Astronomy, University of Kentucky, 505 Rose Street, Lexington, KY 40506-0055 (United States); Kassin, Susan A. [Astrophysics Science Division, Goddard Space Flight Center, Code 665, Greenbelt, MD 20771 (United States); Konidaris, N. P., E-mail: janewman@pitt.edu, E-mail: djm70@pitt.edu, E-mail: m.cooper@uci.edu, E-mail: mdavis@berkeley.edu, E-mail: faber@ucolick.org, E-mail: koo@ucolick.org, E-mail: raja@ucolick.org, E-mail: phillips@ucolick.org [Space Telescope Science Institute, 3700 San Martin Drive, Baltimore, MD 21218 (United States); and others

    2013-09-15

    We describe the design and data analysis of the DEEP2 Galaxy Redshift Survey, the densest and largest high-precision redshift survey of galaxies at z {approx} 1 completed to date. The survey was designed to conduct a comprehensive census of massive galaxies, their properties, environments, and large-scale structure down to absolute magnitude M{sub B} = -20 at z {approx} 1 via {approx}90 nights of observation on the Keck telescope. The survey covers an area of 2.8 deg{sup 2} divided into four separate fields observed to a limiting apparent magnitude of R{sub AB} = 24.1. Objects with z {approx}< 0.7 are readily identifiable using BRI photometry and rejected in three of the four DEEP2 fields, allowing galaxies with z > 0.7 to be targeted {approx}2.5 times more efficiently than in a purely magnitude-limited sample. Approximately 60% of eligible targets are chosen for spectroscopy, yielding nearly 53,000 spectra and more than 38,000 reliable redshift measurements. Most of the targets that fail to yield secure redshifts are blue objects that lie beyond z {approx} 1.45, where the [O II] 3727 A doublet lies in the infrared. The DEIMOS 1200 line mm{sup -1} grating used for the survey delivers high spectral resolution (R {approx} 6000), accurate and secure redshifts, and unique internal kinematic information. Extensive ancillary data are available in the DEEP2 fields, particularly in the Extended Groth Strip, which has evolved into one of the richest multiwavelength regions on the sky. This paper is intended as a handbook for users of the DEEP2 Data Release 4, which includes all DEEP2 spectra and redshifts, as well as for the DEEP2 DEIMOS data reduction pipelines. Extensive details are provided on object selection, mask design, biases in target selection and redshift measurements, the spec2d two-dimensional data-reduction pipeline, the spec1d automated redshift pipeline, and the zspec visual redshift verification process, along with examples of instrumental signatures or

  8. The DEEP2 Galaxy Redshift Survey: Design, Observations, Data Reduction, and Redshifts

    Science.gov (United States)

    Newman, Jeffrey A.; Cooper, Michael C.; Davis, Marc; Faber, S. M.; Coil, Alison L; Guhathakurta, Puraga; Koo, David C.; Phillips, Andrew C.; Conroy, Charlie; Dutton, Aaron A.; Finkbeiner, Douglas P.; Gerke, Brian F.; Rosario, David J.; Weiner, Benjamin J.; Wilmer, C. N. A.; Yan, Renbin; Harker, Justin J.; Kassin, Susan A.; Konidaris, N. P.; Lai, Kamson; Madgwick, Darren S.; Noeske, K. G.; Wirth, Gregory D.; Kirby, Evan N.; Lotz, Jennifer M.

    2013-01-01

    We describe the design and data analysis of the DEEP2 Galaxy Redshift Survey, the densest and largest high-precision redshift survey of galaxies at z approx. 1 completed to date. The survey was designed to conduct a comprehensive census of massive galaxies, their properties, environments, and large-scale structure down to absolute magnitude MB = -20 at z approx. 1 via approx.90 nights of observation on the Keck telescope. The survey covers an area of 2.8 Sq. deg divided into four separate fields observed to a limiting apparent magnitude of R(sub AB) = 24.1. Objects with z approx. galaxies with z > 0.7 to be targeted approx. 2.5 times more efficiently than in a purely magnitude-limited sample. Approximately 60% of eligible targets are chosen for spectroscopy, yielding nearly 53,000 spectra and more than 38,000 reliable redshift measurements. Most of the targets that fail to yield secure redshifts are blue objects that lie beyond z approx. 1.45, where the [O ii] 3727 Ang. doublet lies in the infrared. The DEIMOS 1200 line mm(exp -1) grating used for the survey delivers high spectral resolution (R approx. 6000), accurate and secure redshifts, and unique internal kinematic information. Extensive ancillary data are available in the DEEP2 fields, particularly in the Extended Groth Strip, which has evolved into one of the richest multiwavelength regions on the sky. This paper is intended as a handbook for users of the DEEP2 Data Release 4, which includes all DEEP2 spectra and redshifts, as well as for the DEEP2 DEIMOS data reduction pipelines. Extensive details are provided on object selection, mask design, biases in target selection and redshift measurements, the spec2d two-dimensional data-reduction pipeline, the spec1d automated redshift pipeline, and the zspec visual redshift verification process, along with examples of instrumental signatures or other artifacts that in some cases remain after data reduction. Redshift errors and catastrophic failure rates are assessed

  9. The DEEP2 Galaxy Redshift Survey: Design, Observations, Data Reduction, and Redshifts

    OpenAIRE

    Newman, Jeffrey A.; Kassin, Susan A.; Noeske, K. G.; Lotz, Jennifer M.

    2013-01-01

    We describe the design and data analysis of the DEEP2 Galaxy Redshift Survey, the densest and largest high-precision redshift survey of galaxies at z ~ 1 completed to date. The survey was designed to conduct a comprehensive census of massive galaxies, their properties, environments, and large-scale structure down to absolute magnitude M_B = −20 at z ~ 1 via ~90 nights of observation on the Keck telescope. The survey covers an area of 2.8 deg^2 divided into four separate fields observed to a l...

  10. Predictive Value of Clinical Findings and Plasma Biomarkers after Fourteen Days of Prednisone Treatment for Acute Graft-versus-host Disease.

    Science.gov (United States)

    McDonald, George B; Tabellini, Laura; Storer, Barry E; Martin, Paul J; Lawler, Richard L; Rosinski, Steven L; Schoch, H Gary; Hansen, John A

    2017-08-01

    We examined the hypothesis that plasma biomarkers and concomitant clinical findings after initial glucocorticoid therapy can accurately predict failure of graft-versus-host-disease (GVHD) treatment and mortality. We analyzed plasma samples and clinical data in 165 patients after 14 days of glucocorticoid therapy and used logistic regression and areas under receiver-operating characteristic curves (AUC) to evaluate associations with treatment failure and nonrelapse mortality (NRM). Initial treatment of GVHD was unsuccessful in 49 patients (30%). For predicting GVHD treatment failure, the best clinical combination (total serum bilirubin and skin GVHD stage: AUC, .70) was competitive with the best biomarker combination (T cell immunoglobulin and mucin domain 3 [TIM3] and [interleukin 1 receptor family encoded by the IL1RL1 gene, ST2]: AUC, .73). The combination of clinical features and biomarker results offered only a slight improvement (AUC, .75). For predicting NRM at 1 year, the best clinical predictor (total serum bilirubin: AUC, .81) was competitive with the best biomarker combination (TIM3 and soluble tumor necrosis factor receptor-1 [sTNFR1]: AUC, .85). The combination offered no improvement (AUC, .85). Infection was the proximate cause of death in virtually all patients. We conclude that after 14 days of glucocorticoid therapy, clinical findings (serum bilirubin, skin GVHD) and plasma biomarkers (TIM3, ST2, sTNFR1) can predict failure of GVHD treatment and NRM. These biomarkers reflect counter-regulatory mechanisms and provide insight into the pathophysiology of GVHD reactions after glucocorticoid treatment. The best predictive models, however, exhibit inadequate positive predictive values for identifying high-risk GVHD cohorts for investigational trials, as only a minority of patients with high-risk GVHD would be identified and most patients would be falsely predicted to have adverse outcomes. Copyright © 2017 The American Society for Blood and Marrow

  11. Redshift drift exploration for interacting dark energy

    Energy Technology Data Exchange (ETDEWEB)

    Geng, Jia-Jia; Li, Yun-He; Zhang, Jing-Fei [Northeastern University, Department of Physics, College of Sciences, Shenyang (China); Zhang, Xin [Northeastern University, Department of Physics, College of Sciences, Shenyang (China); Peking University, Center for High Energy Physics, Beijing (China)

    2015-08-15

    By detecting redshift drift in the spectra of the Lyman-α forest of distant quasars, the Sandage-Loeb (SL) test directly measures the expansion of the universe, covering the ''redshift desert'' of 2 redshift drift observations would help break the geometric degeneracies in a meaningful way, thus the measurement precisions of Ω{sub m}, H{sub 0}, w, and γ could be substantially improved using future probes. (orig.)

  12. Detecting Dual AGN at High Redshift

    Science.gov (United States)

    Barrows, Robert S.

    2012-01-01

    The existence of supermassive black holes (SMBHs) in most, if not all, galaxies, along with observations of galaxy mergers, suggests that pairs of SMBHs should exist for some time in the merger remnant. Observational evidence for these systems at kpc-scale separations (i.e. dual AGN) has dramatically increased recently through a combination of spectral and morphological selections. I discuss observations of CXOXBJ142607.6+353351 (CXOJ1426+35), a candidate dual AGN at z=1.175, and put its properties, including significant obscuration, within the context of other candidate/confirmed dual AGN at lower redshifts. Though dual AGN are expected to be more common at higher redshifts, they are more difficult to detect. Furthermore, adding to the difficulties of detection are a number of other physical mechanisms which can mimic the spectroscopic signature of two Type 2 AGN. In particular, I will discuss the possibility of strong outflows from an AGN. These outflow phenomena can be an important feedback mechanism in galaxies and are apparently common in AGN, making them a viable alternative to the dual AGN scenario. Based on our candidate's luminosity and emission line intensities, we find that an outflow is a possibility. If this is the case, such an outflow would be especially strong and has implications for AGN feedback in galaxies. However, the dual AGN scenario cannot be ruled out, and at z=1.175, the two putative AGN could potentially be resolved with Chandra. Other candidate dual AGN at similar redshifts and with significant obscuration could also be confirmed this way. This research was sponsored by the Strategic University Research Partnership Program, the National Aeronautics and Space Administration and the Arkansas NASA EPSCoR program.

  13. Redshift-space distortions around voids

    Science.gov (United States)

    Cai, Yan-Chuan; Taylor, Andy; Peacock, John A.; Padilla, Nelson

    2016-11-01

    We have derived estimators for the linear growth rate of density fluctuations using the cross-correlation function (CCF) of voids and haloes in redshift space. In linear theory, this CCF contains only monopole and quadrupole terms. At scales greater than the void radius, linear theory is a good match to voids traced out by haloes; small-scale random velocities are unimportant at these radii, only tending to cause small and often negligible elongation of the CCF near its origin. By extracting the monopole and quadrupole from the CCF, we measure the linear growth rate without prior knowledge of the void profile or velocity dispersion. We recover the linear growth parameter β to 9 per cent precision from an effective volume of 3( h-1Gpc)3 using voids with radius >25 h-1Mpc. Smaller voids are predominantly sub-voids, which may be more sensitive to the random velocity dispersion; they introduce noise and do not help to improve measurements. Adding velocity dispersion as a free parameter allows us to use information at radii as small as half of the void radius. The precision on β is reduced to 5 per cent. Voids show diverse shapes in redshift space, and can appear either elongated or flattened along the line of sight. This can be explained by the competing amplitudes of the local density contrast, plus the radial velocity profile and its gradient. The distortion pattern is therefore determined solely by the void profile and is different for void-in-cloud and void-in-void. This diversity of redshift-space void morphology complicates measurements of the Alcock-Paczynski effect using voids.

  14. Dark energy with fine redshift sampling

    Science.gov (United States)

    Linder, Eric V.

    2007-03-01

    The cosmological constant and many other possible origins for acceleration of the cosmic expansion possess variations in the dark energy properties slow on the Hubble time scale. Given that models with more rapid variation, or even phase transitions, are possible though, we examine the fineness in redshift with which cosmological probes can realistically be employed, and what constraints this could impose on dark energy behavior. In particular, we discuss various aspects of baryon acoustic oscillations, and their use to measure the Hubble parameter H(z). We find that currently considered cosmological probes have an innate resolution no finer than Δz≈0.2 0.3.

  15. THE LOW-REDSHIFT CARNEGIE SUPERNOVA PROJECT

    Directory of Open Access Journals (Sweden)

    G. Folatelli

    2009-01-01

    Full Text Available We present the low-redshift Carnegie Supernova Project (CSP, an undergoing program to follow up about 250 nearby supernovae (SNe of all types. We brie y describe the observations which yield well-sampled, highly precise optical and near-infrared light curves in a well-understood photometric system, complemented with optical spectroscopy. As one of the main goals of the CSP, we preliminarily present the rst Hubble diagram using a sample of 30 Type-Ia SNe (SNe Ia.

  16. GRB 080913 at redshift 6.7

    DEFF Research Database (Denmark)

    Greiner, J.; Krühler, T.; Fynbo, J. P. U.

    2009-01-01

    We report on the detection by Swift of GRB 080913, and subsequent optical/near-infrared follow-up observations by GROND, which led to the discovery of its optical/NIR afterglow and the recognition of its high-z nature via the detection of a spectral break between the i' and z' bands. Spectroscopy...... obtained at the ESO-VLT revealed a continuum extending down to ¿ = 9400 Å, and zero flux for 7500 Åz = 6.695± 0.025 (95.5% confidence level), making GRB 080913 the highest-redshift gamma-ray burst (GRB) to date, and more distant than...

  17. A catalogue of high redshift clusters

    Directory of Open Access Journals (Sweden)

    R. Juncosa

    2007-01-01

    Full Text Available Distant clusters of galaxies provide a powerful method to study the formation and evolution of galaxies and large scale structure of the Universe. However, the number of known clusters at high redshift (z > 0.5 is still limited. As a preparatory work for detailed studies with GTC, we are building a cata- logue of such objects analyzing public deep wide optical and near-IR surveys. In a region of ~9 square degrees, ~100 new clusters (~ 60 of them at z > 0.5 have been detected.

  18. Seminal plasma concentrations of Anti-Müllerian hormone and inhibin B predict motile sperm recovery from cryopreserved semen in asthenozoospermic men: a prospective cohort study.

    Science.gov (United States)

    Nery, S F; Vieira, M A F; Dela Cruz, C; Lobach, V N M; Del Puerto, H L; Torres, P B; Rocha, A L L; Reis, A B; Reis, F M

    2014-11-01

    The rate of motile sperm recovery after cryopreservation is very variable and difficult to predict. Anti-Müllerian hormone (AMH) and inhibin B are produced by Sertoli cells and released into the seminal plasma, where they could be functional markers of spermatogenesis and sperm resistance to thermal stress. The aim of this study was to evaluate whether seminal plasma levels of AMH and inhibin B predict sperm recovery after cryopreservation. The study included 153 men enrolled prospectively during a semen analysis. The cohort was stratified by the fresh semen characteristics into: normal (n = 52), high sperm count (n = 55), asthenozoospermia (n = 23), and oligozoospermia (n = 23). The main outcome measure was motile sperm recovery rate, defined as post-thaw total motile sperm count × 100/pre-freezing total motile sperm count. In men with asthenozoospermia there was a significant correlation between motile sperm recovery rate and the pre-freezing concentrations of AMH (r = 0.522, p < 0.05) and inhibin B (0.471, p < 0.05). In this group, the areas under the receiver operating characteristic curves of AMH and inhibin B for prediction of ≥50% motile sperm recovery after cryopreservation were, respectively, 0.808 and 0.638. AMH was particularly useful, with sensitivity of 0.85, specificity of 0.80, positive predictive value of 0.84 and negative predictive value of 0.80. The sensitivity, specificity, positive, and negative predictive values of inhibin B for the same outcome were, respectively, 0.62, 0.60, 0.67, and 0.55. The median motile sperm recovery rate was 83% when seminal plasma AMH concentration was ≥0.84 ng/mL, vs. 27% when AMH concentration was <0.84 ng/mL (p < 0.05). In other patient groups, there was no correlation between the two hormone levels in seminal plasma and the motile sperm recovery rate. In conclusion, seminal plasma AMH and inhibin B concentrations correlate with and can be used to predict motile sperm recovery after semen

  19. Redshift distribution of Lyα lines and metal systems

    Science.gov (United States)

    Demiański, M.; Doroshkevich, A. G.; Turchaninov, V.

    2000-11-01

    The observed redshift distribution of Lyα lines and metal systems is examined in order to discriminate and to trace the evolution of structure elements observed in the galaxy distribution, at small redshifts, and to test the theoretical description of structure evolution. We show that the expected evolution of a filamentary component of structure describes quite well the redshift distribution of metal systems and stronger Lyα lines with log(NHi)>=14, at z<=3. The redshift distribution of weaker Lyα lines can be attributed to the population of poorer structure elements (Zel'dovich pancakes), which were formed at high redshifts from the invisible dark matter and non-luminous baryonic matter, and which at lower redshifts are mainly merged and dispersed.

  20. The DEEP Groth Strip Galaxy Redshift Survey. III. Redshift Catalog and Properties of Galaxies

    CERN Document Server

    Weiner, B J; Faber, S M; Willmer, C N A; Vogt, N P; Simard, L; Gebhardt, K; Im, M; Koo, D C; Sarajedini, V L; Wu, K L; Forbes, D A; Gronwall, C; Groth, E J; Illingworth, G D; Kron, R G; Rhodes, J; Szalay, A S; Takamiya, M; Weiner, Benjamin J.; Phillips, Andrew C.; Willmer, Christopher N.A.; Vogt, Nicole P.; Simard, Luc; Gebhardt, Karl; Im, Myungshin; Sarajedini, Vicki L.; Wu, Katherine L.; Forbes, Duncan A.; Gronwall, Caryl; Groth, Edward J.; Rhodes, Jason

    2004-01-01

    The Deep Extragalactic Evolutionary Probe (DEEP) is a series of spectroscopic surveys of faint galaxies, targeted at the properties and clustering of galaxies at redshifts z ~ 1. We present the redshift catalog of the DEEP 1 GSS pilot phase of this project, a Keck/LRIS survey in the HST/WFPC2 Groth Survey Strip. The redshift catalog and data, including reduced spectra, are publicly available through a Web-accessible database. The catalog contains 658 secure galaxy redshifts with a median z=0.65, and shows large-scale structure walls to z = 1. We find a bimodal distribution in the galaxy color-magnitude diagram which persists to z = 1. A similar color division has been seen locally by the SDSS and to z ~ 1 by COMBO-17. For red galaxies, we find a reddening of only 0.11 mag from z ~ 0.8 to now, about half the color evolution measured by COMBO-17. We measure structural properties of the galaxies from the HST imaging, and find that the color division corresponds generally to a structural division. Most red galaxi...

  1. Imaging of Three Possible Low Redshift Analogs to High Redshift Compact Red Galaxies

    CERN Document Server

    Shih, Hsin-Yi

    2011-01-01

    As part of a larger program to identify and characterize possible low-redshift analogs to massive compact red galaxies found at high redshift, we have examined the morphologies of three low-redshift compact galaxies drawn from the sample of Trujillo et al. (2009). Using deeper and higher resolution images, we have found faint and relatively extensive outer structures in addition to the compact cores identified in the earlier measurements. One object appears to have a small companion that may be involved in an ongoing minor merger of the sort that could be responsible for building up the outer parts of these galaxies. The ages of the dominant stellar populations in these objects are found to be around 2--4 Gyr, in good agreement with the previous estimates. The presence of diffuse outer structures in these galaxies indicates that truly compact and massive red galaxies are exceedingly rare at low redshift. The relatively young stellar populations suggest that the accretion of the extensive outer material must o...

  2. Linear redshift space distortions for cosmic voids based on galaxies in redshift space

    CERN Document Server

    Chuang, Chia-Hsun; Liang, Yu; Font-Ribera, Andreu; Zhao, Cheng; McDonald, Patrick; Tao, Charling

    2016-01-01

    Cosmic voids found in galaxy surveys are defined based on the galaxy distribution in redshift space. We show that the large scale distribution of voids in redshift space traces the fluctuations in the dark matter density field \\delta(k) (in Fourier space with \\mu being the line of sight projected k-vector): \\delta_v^s(k) = (1 + \\beta_v \\mu^2) b^s_v \\delta(k), with a beta factor that will be in general different than the one describing the distribution of galaxies. Only in case voids could be assumed to be quasi-local transformations of the linear (Gaussian) galaxy redshift space field, one gets equal beta factors \\beta_v=\\beta_g=f/b_g with f being the growth rate, and b_g, b^s_v being the galaxy and void bias on large scales defined in redshift space. Indeed, in our mock void catalogs we measure void beta factors being in good agreement with the galaxy one. Further work needs to be done to confirm the level of accuracy of the beta factor equality between voids and galaxies, but in general the void beta factor...

  3. TK Modeler version 1.0, a Microsoft® Excel®-based modeling software for the prediction of diurnal blood/plasma concentration for toxicokinetic use.

    Science.gov (United States)

    McCoy, Alene T; Bartels, Michael J; Rick, David L; Saghir, Shakil A

    2012-07-01

    TK Modeler 1.0 is a Microsoft® Excel®-based pharmacokinetic (PK) modeling program created to aid in the design of toxicokinetic (TK) studies. TK Modeler 1.0 predicts the diurnal blood/plasma concentrations of a test material after single, multiple bolus or dietary dosing using known PK information. Fluctuations in blood/plasma concentrations based on test material kinetics are calculated using one- or two-compartment PK model equations and the principle of superposition. This information can be utilized for the determination of appropriate dosing regimens based on reaching a specific desired C(max), maintaining steady-state blood/plasma concentrations, or other exposure target. This program can also aid in the selection of sampling times for accurate calculation of AUC(24h) (diurnal area under the blood concentration time curve) using sparse-sampling methodologies (one, two or three samples). This paper describes the construction, use and validation of TK Modeler. TK Modeler accurately predicted blood/plasma concentrations of test materials and provided optimal sampling times for the calculation of AUC(24h) with improved accuracy using sparse-sampling methods. TK Modeler is therefore a validated, unique and simple modeling program that can aid in the design of toxicokinetic studies.

  4. A study of high-redshift AGN feedback in SZ cluster samples

    Science.gov (United States)

    Bîrzan, L.; Rafferty, D. A.; Brüggen, M.; Intema, H. T.

    2017-10-01

    We present a study of active galactic nucleus (AGN) feedback at higher redshifts (0.3 samples of clusters from the South Pole Telescope and Atacama Cosmology Telescope surveys. In contrast to studies of nearby systems, we do not find a separation between cooling flow (CF) clusters and non-CF clusters based on the radio luminosity of the central radio source (cRS). This lack may be due to the increased incidence of galaxy-galaxy mergers at higher redshift that triggers AGN activity. In support of this scenario, we find evidence for evolution in the radio-luminosity function of the cRS, while the lower luminosity sources do not evolve much, the higher luminosity sources show a strong increase in the frequency of their occurrence at higher redshifts. We interpret this evolution as an increase in high-excitation radio galaxies (HERGs) in massive clusters at z > 0.6, implying a transition from HERG-mode accretion to lower power low-excitation radio galaxy (LERG)-mode accretion at intermediate redshifts. Additionally, we use local radio-to-jet power scaling relations to estimate feedback power and find that half of the CF systems in our sample probably have enough heating to balance cooling. However, we postulate that the local relations are likely not well suited to predict feedback power in high-luminosity HERGs, as they are derived from samples composed mainly of lower luminosity LERGs.

  5. Estimating Photometric Redshifts with Artificial Neural Networks and Multi-Parameters

    Institute of Scientific and Technical Information of China (English)

    Li-Li Li; Yan-Xia Zhang; Yong-Heng Zhao; Da-Wei Yang

    2007-01-01

    We calculate photometric redshifts from the Sloan Digital Sky Survey Data Release 2 (SDSS DR2) Galaxy Sample using artificial neural networks(ANNs).Different input sets based on various parameters(e.g.magnitude,color index,flux information)are explored.Mainly,parameters from broadband photometry are utilized and their performances in redshift prediction are compared.While any parameter may be easily incorporated in the input,our results indicate that using the dereddened magnitudes often produces more accurate photometric redshifts than using the Petrosian magnitudes or model magnitudes as input.but the model magnitudes are superior to the Petrosian magnitudes.Also,better performance results when more effective parameters are used in the training set.The method is tested on a sample of 79 346 galaxies from the SDSS DR2.When using 19 parameters based on the dereddened magnitudes,the rms error in redshift estimation is σz=0.020184.The ANN is highly competitive tool compared to the traditional template-fitting methods when a 1arge and representative training set is available.

  6. The Space Density of High-Redshift QSOs in the GOODS Survey

    CERN Document Server

    Cristiani, S; Bauer, F; Brandt, W N; Chatzichristou, E T; Fontanot, F; Grazian, A; Koekemoer, A M; Lucas, R A; Monaco, P; Nonino, M; Padovani, P; Stern, D; Tozzi, P; Treister, E; Urry, C M; Vanzella, E

    2004-01-01

    We present a sample of 17 high-redshift (3.5redshifts we estimate that the final sample will contain between two and four QSOs with 4redshift, moderate-luminosity (M_{145}=~-23) QSOs is observed with respect to predictions based on a) the extrapolation of the z~2.7 luminosity function (LF), according to a pure luminosity evolution calibrated by the results of the Sloan Digital Sky Survey; and b) a constant universal efficiency in the formation of super-massive black holes (SMBHs) in dark-matter halos. Evidence is gathered in favor of a density evolution of the LF at high redshift and of a suppress...

  7. Empirical solutions to the high-redshift overproduction of stars in modeled dwarf galaxies

    CERN Document Server

    White, Catherine E; Ferguson, Henry C

    2014-01-01

    Both numerical hydrodynamic and semi-analytic cosmological models of galaxy formation struggle to match observed star formation histories of galaxies in low-mass halos (M$_{\\rm{H}} \\lesssim 10^{11}$ \\msun), predicting more star formation at high redshift and less star formation at low redshift than observed. The fundamental problem is that galaxies' gas accretion and star formation rates are too closely coupled in the models: the accretion rate largely drives the star formation rate. Observations point to gas accretion rates that outpace star formation at high redshift, resulting in a buildup of gas and a delay in star formation until lower redshifts. We present three empirical adjustments of standard recipes in a semi-analytic model motivated by three physical scenarios that could cause this decoupling: 1) the mass loading factors of outflows driven by stellar feedback may have a steeper dependence on halo mass at earlier times, 2) the efficiency of star formation may be lower in low mass halos at high redsh...

  8. Gravitational wave source counts at high redshift and in models with extra dimensions

    CERN Document Server

    García-Bellido, Juan; Trashorras, Manuel

    2016-01-01

    Gravitational wave (GW) source counts have been recently shown to be able to test how gravitational radiation propagates with the distance from the source. Here, we extend this formalism to cosmological scales, i.e. the high redshift regime, and we also allow for models with large or compactified extra dimensions like in the Kaluza-Klein (KK) model. We found that in the high redshift regime one would potentially expect two windows where observations above the minimum signal-to-noise threshold can be made, assuming there are no higher order corrections in the redshift dependence of the signal-to-noise $S/N(z)$ for the expected prediction. Furthermore, we also considered the case of intermediate redshifts, i.e. $0

  9. Detection of Large-Scale Structure in a $B<17^{m}$ Galaxy Redshift Survey

    CERN Document Server

    Ratcliffe, A; Broadbent, A J; Parker, Q A; Watson, F G; Oates, A P; Fong, R; Collins, C A

    1996-01-01

    We report on results from the Durham/UKST Galaxy Redshift Survey where we have found large scale ``cellular'' features in the galaxy distribution. These have spatial 2-point correlation function power significantly in excess of the predictions of the standard cold dark matter cosmological model^{1}, supporting the previous observational results from the APM survey^{2,3}. At smaller scales, the 1-D pairwise galaxy velocity dispersion is measured to be \\bf 387^{+96}_{-62} kms^{-1} which is also inconsistent with the prediction of the standard cold dark matter model^{1}. Finally, the survey has produced the most significant detection yet of large scale redshift space distortions due to dynamical infall of galaxies^{4}. An estimate of \\bf \\Omega^{0.6}/b = 0.55 \\pm 0.12 is obtained which is consistent either with a low density Universe or a critical density Universe where galaxies are biased tracers of the mass.

  10. Effects of the sources of reionization on 21-cm redshift-space distortions

    CERN Document Server

    Majumdar, Suman; Mellema, Garrelt; Chapman, Emma; Abdalla, Filipe B; Lee, Kai-Yan; Iliev, Ilian T; Dixon, Keri L; Datta, Kanan K; Ciardi, Benedetta; Fernandez, Elizabeth R; Jelić, Vibor; Koopmans, Léon V E; Zaroubi, Saleem

    2015-01-01

    The observed 21-cm signal from the epoch of reionization will be distorted along the line-of-sight by the peculiar velocities of matter particles. These redshift-space distortions will affect the contrast in the signal and will also make it anisotropic. This anisotropy contains information about the cross-correlation between the matter density field and the neutral hydrogen field, and could thus potentially be used to extract information about the sources of reionization. In this paper, we study a collection of simulated reionization scenarios assuming different models for the sources of reionization. We show that the 21-cm anisotropy is best measured by the quadrupole moment of the power spectrum. We find that, unless the properties of the reionization sources are extreme in some way, the quadrupole moment evolves very predictably as a function of global neutral fraction. This predictability implies that redshift-space distortions are not a very sensitive tool for distinguishing between reionization sources....

  11. Redshift or adduct stabilization -- a computational study of hydrogen bonding in adducts of protonated carboxylic acids

    DEFF Research Database (Denmark)

    Olesen, Solveig Gaarn; Hammerum, Steen

    2009-01-01

    changes and the redshift favor the Z OH group, matching the results of NBO and AIM calculations. This reflects that the thermochemistry of adduct formation is not a good measure of the hydrogen bond strength in charged adducts, and that the ionic interactions in the E and Z adducts of protonated......It is generally expected that the hydrogen bond strength in a D-H-A adduct is predicted by the difference between the proton affinities of D and A, measured by the adduct stabilization, and demonstrated by the IR redshift of the D-H bond stretching vibrational frequency. These criteria do...... not always yield consistent predictions, as illustrated by the hydrogen bonds formed by the E and Z OH groups of protonated carboxylic acids. The delta-PA and the stabilization of a series of hydrogen bonded adducts indicate that the E OH group forms the stronger hydrogen bonds, whereas the bond length...

  12. Redshift drift constraints on holographic dark energy

    Science.gov (United States)

    He, Dong-Ze; Zhang, Jing-Fei; Zhang, Xin

    2017-03-01

    The Sandage-Loeb (SL) test is a promising method for probing dark energy because it measures the redshift drift in the spectra of Lyman- α forest of distant quasars, covering the "redshift desert" of 2 ≲ z ≲ 5, which is not covered by existing cosmological observations. Therefore, it could provide an important supplement to current cosmological observations. In this paper, we explore the impact of SL test on the precision of cosmological constraints for two typical holographic dark energy models, i.e., the original holographic dark energy (HDE) model and the Ricci holographic dark energy (RDE) model. To avoid data inconsistency, we use the best-fit models based on current combined observational data as the fiducial models to simulate 30 mock SL test data. The results show that SL test can effectively break the existing strong degeneracy between the present-day matter density Ωm0 and the Hubble constant H 0 in other cosmological observations. For the considered two typical dark energy models, not only can a 30-year observation of SL test improve the constraint precision of Ωm0 and h dramatically, but can also enhance the constraint precision of the model parameters c and α significantly.

  13. Redshift drift constraints on holographic dark energy

    CERN Document Server

    He, Dong-Ze; Zhang, Xin

    2016-01-01

    The Sandage-Loeb (SL) test is a promising method for probing dark energy because it measures the redshift drift in the spectra of Lyman-$\\alpha$ forest of distant quasars, covering the "redshift desert" of $2\\lesssim z\\lesssim5$, which is not covered by existing cosmological observations. Therefore, it could provide an important supplement to current cosmological observations. In this paper, we explore the impact of SL test on the precision of cosmological constraints for two typical holographic dark energy models, i.e., the original holographic dark energy (HDE) model and the Ricci holographic dark energy (RDE) model. To avoid data inconsistency, we use the best-fit models based on current combined observational data as the fiducial models to simulate 30 mock SL test data. The results show that SL test can effectively break the existing strong degeneracy between the present-day matter density $\\Omega_{m0}$ and the Hubble constant $H_0$ in other cosmological observations. For the considered two typical dark e...

  14. Quasar Elemental Abundances at High Redshifts

    DEFF Research Database (Denmark)

    Dietrich, M.; Hamann, F.; Shields, J. C.

    2003-01-01

    We examine rest-frame ultraviolet spectra of 70 high redshift quasars (z>3.5) to study the chemical enrichment history of the gas closely related to the quasars, and thereby estimate the epoch of first star formation. The fluxes of several ultraviolet emission lines were investigated within...... the framework of the most recent photoionization models to estimate the metallicity of the gas associated with the high-z quasars. Standard photoionization parameters and the assumption of secondary nitrogen enrichment indicate an average abundance of Z/Z_sol = 4 to 5 in the line emitting gas. Assuming a time...... scale of t_evol = 0.5 - 0.8 Gyrs for the chemical enrichment of the gas, the first major star formation for quasars with z>=4 should have started at a redshift of z_f = 6 - 8, corresponding to an age of the universe of several 10^8 yrs (H_o = 65 km/s/Mpc, Omega_M = 0.3, Omega_Lambda = 0.7). We note...

  15. Survey For Very High-Redshift Quasars

    Science.gov (United States)

    Lemley, S.; MacAlpine, G.

    1997-12-01

    I will present the results from the deep, three color survey for very high redshift quasars. The survey involved direct imaging through Gunn gri filters using a 2048 x 2048 STIS ccd chip and Cerro Tololo's Curtis Scmidt Telescope. Quasar candidates in the range 4.0 < z < 5.4 were selected based on the detection of the Lyman alpha line and the strong drop in the spectrum blueward of this. Because of this response, quasars are clearly located away from the stellar locus on g - r vs. r - i diagrams. Quasar candidates in this redshift range have large values of g - r and small values of r - i. To confirm the candidates as quasars, the multi-fiber spectroscope Hydra, located on the WIYN telescope, was used. To date, spectral confirmation has been completed for ten degrees out of the approximately fifteen square degress of survey area. Several quasars were discovered, and I will present their spectra and information on the viability of this technique.

  16. Quasar Elemental Abundances at High Redshifts

    CERN Document Server

    Dietrich, M; Shields, J C; Constantin, A; Heidt, J; Jäger, K; Vestergaard, M; Wagner, S J

    2003-01-01

    We examine rest-frame ultraviolet spectra of 70 high redshift quasars (z>3.5) to study the chemical enrichment history of the gas closely related to the quasars, and thereby estimate the epoch of first star formation. The fluxes of several ultraviolet emission lines were investigated within the framework of the most recent photoionization models to estimate the metallicity of the gas associated with the high-z quasars. Standard photoionization parameters and the assumption of secondary nitrogen enrichment indicate an average abundance of Z/Z_sol = 4 to 5 in the line emitting gas. Assuming a time scale of t_evol = 0.5 - 0.8 Gyrs for the chemical enrichment of the gas, the first major star formation for quasars with z>=4 should have started at a redshift of z_f = 6 - 8, corresponding to an age of the universe of several 10^8 yrs (H_o = 65 km/s/Mpc, Omega_M = 0.3, Omega_Lambda = 0.7). We note that this also appears to be the era of re-ionization of the universe. Finally, there is some evidence for a positive lum...

  17. Redshift drift exploration for interacting dark energy

    CERN Document Server

    Geng, Jia-Jia; Zhang, Jing-Fei; Zhang, Xin

    2015-01-01

    By detecting redshift drift in the spectra of Lyman-$\\alpha$ forest of distant quasars, Sandage-Loeb (SL) test directly measures the expansion of the universe, covering the "redshift desert" of $2 \\lesssim z \\lesssim5$. Thus this method is definitely an important supplement to the other geometric measurements and will play a crucial role in cosmological constraints. In this paper, we quantify the ability of SL test signal by a CODEX-like spectrograph for constraining interacting dark energy. Four typical interacting dark energy models are considered: (\\romannumeral1) $Q=\\gamma H\\rho_c$, (\\romannumeral2) $Q=\\gamma H\\rho_{de}$, (\\romannumeral3) $Q=\\gamma H_0\\rho_c$, and (\\romannumeral4) $Q=\\gamma H_0\\rho_{de}$. The results show that for all the considered interacting dark energy models, relative to the current joint SN+BAO+CMB+$H_0$ observations, the constraints on $\\Omega_m$ and $H_0$ would be improved by about 60\\% and 30--40\\%, while the constraints on $w$ and $\\gamma$ would be slightly improved, with a 30-y...

  18. Redshift-space distortions around voids

    CERN Document Server

    Cai, Yan-Chuan; Peacock, John A; Padilla, Nelson

    2016-01-01

    We have derived estimators for the linear growth rate of density fluctuations using the cross-correlation function of voids and haloes in redshift space, both directly and in Fourier form. In linear theory, this cross-correlation contains only monopole and quadrupole terms. At scales greater than the void radius, linear theory is a good match to voids traced out by haloes in N-body simulations; small-scale random velocities are unimportant at these radii, only tending to cause small and often negligible elongation of the redshift-space cross-correlation function near its origin. By extracting the monopole and quadrupole from the cross-correlation function, we measure the linear growth rate without prior knowledge of the void profile or velocity dispersion. We recover the linear growth parameter $\\beta$ to 9% precision from an effective volume of 3(Gpc/h)^3 using voids with radius greater than 25Mpc/h. Smaller voids are predominantly sub-voids, which may be more sensitive to the random velocity dispersion; the...

  19. The Low-Redshift Intergalactic Medium

    CERN Document Server

    Shull, J M; Stocke, J T; Penton, Steven V.; Stocke, John T.

    1999-01-01

    The low-redshift Ly-alpha forest of absorption lines provides a probe of large-scale baryonic structures in the intergalactic medium, some of which may be remnants of physical conditions set up during the epoch of galaxy formation. We discuss our recent Hubble Space Telescope (HST) observations and interpretation of low-z Ly-alpha clouds toward nearby Seyferts and QSOs, including their frequency, space density, estimated mass, association with galaxies, and contribution to Omega-baryon. Our HST/GHRS detections of 70 Ly-alpha absorbers with N_HI > 10^12.6 cm-2 along 11 sightlines covering pathlength Delta(cz) = 114,000 km/s show f(>N_HI) ~ N_HI^{-0.63 +- 0.04} and a line frequency dN/dz = 200 +- 40 for N_HI > 10^12.6 cm-2 (one every 1500 km/s of redshift). A group of strong absorbers toward PKS 2155-304 may be associated with gas (400-800) h_75^-1 kpc from 4 large galaxies, with low metallicity (< 0.003 solar) and D/H < 2 x 10^-4. At low-z, we derive a metagalactic ionizing radiation field from AGN of J_...

  20. The environment of low redshift quasar pairs

    CERN Document Server

    Sandrinelli, Angela; Treves, Aldo; Farina, Emanuele Paolo; Uslenghi, Michela

    2014-01-01

    We investigate the properties of the galaxy environment of a sample of 14 low redshift (z $<$ 0.85) quasar physical pairs extracted from SDSS DR10 archives. The pairs have a systemic radial velocity difference $\\Delta V_\\parallel \\leqslant$ 600 $km \\ s^{-1}$ (based on [OIII]5007 \\AA \\ line) and projected distance $ R_\\bot \\leqslant$ 600 kpc. The physical association of the pairs is statistically confirmed at a level of $\\sim$ 90 %. For most of the images of these quasars we are able to resolve their host galaxies that turn out to be on average similar to those of quasars not in pairs. We also found that quasars in a pair are on average in region of modest galaxy overdensity extending up 0.5 Mpc from the QSO. This galaxy overdensity is indistinguishable from that of a homogeneous sample of isolated quasars at the same redshift and with similar host galaxy luminosity. These results, albeit derived from a small (but homogeneous) sample of objects, suggest that the rare activation of two quasars with small phy...

  1. The relativistic geoid: redshift and acceleration potential

    Science.gov (United States)

    Philipp, Dennis; Lämmerzahl, Claus; Puetzfeld, Dirk; Hackmann, Eva; Perlick, Volker

    2017-04-01

    We construct a relativistic geoid based on a time-independent redshift potential, which foliates the spacetime into isochronometric surfaces. This relativistic potential coincides with the acceleration potential for isometric congruences. We show that the a- and u- geoid, defined in a post-Newtonian framework, coincide also in a more general setup. Known Newtonian and post-Newtonian results are recovered in the respective limits. Our approach offers a relativistic definition of the Earth's geoid as well as a description of the Earth itself (or observers on its surface) in terms of an isometric congruence. Being fully relativistic, this notion of a geoid can also be applied to other compact objects such as neutron stars. By definition, this relativistic geoid can be determined by a congruence of Killing observers equipped with standard clocks by comparing their frequencies as well as by measuring accelerations of objects that follow the congruence. The redshift potential gives the correct result also for frequency comparison through optical fiber links as long as the fiber is at rest w.r.t. the congruence. We give explicit expressions for the relativistic geoid in the Kerr spacetime and the Weyl class of spacetimes. To investigate the influence of higher order mass multipole moments we compare the results for the Schwarzschild case to those obtained for the Erez-Rosen and q-metric spacetimes.

  2. Clustering-based redshift estimation: application to VIPERS/CFHTLS

    Science.gov (United States)

    Scottez, V.; Mellier, Y.; Granett, B. R.; Moutard, T.; Kilbinger, M.; Scodeggio, M.; Garilli, B.; Bolzonella, M.; de la Torre, S.; Guzzo, L.; Abbas, U.; Adami, C.; Arnouts, S.; Bottini, D.; Branchini, E.; Cappi, A.; Cucciati, O.; Davidzon, I.; Fritz, A.; Franzetti, P.; Iovino, A.; Krywult, J.; Le Brun, V.; Le Fèvre, O.; Maccagni, D.; Małek, K.; Marulli, F.; Polletta, M.; Pollo, A.; Tasca, L. A. M.; Tojeiro, R.; Vergani, D.; Zanichelli, A.; Bel, J.; Coupon, J.; De Lucia, G.; Ilbert, O.; McCracken, H. J.; Moscardini, L.

    2016-10-01

    We explore the accuracy of the clustering-based redshift estimation proposed by Ménard et al. when applied to VIMOS Public Extragalactic Redshift Survey (VIPERS) and Canada-France-Hawaii Telescope Legacy Survey (CFHTLS) real data. This method enables us to reconstruct redshift distributions from measurement of the angular clustering of objects using a set of secure spectroscopic redshifts. We use state-of-the-art spectroscopic measurements with iAB 0.5 which allows us to test the accuracy of the clustering-based redshift distributions. We show that this method enables us to reproduce the true mean colour-redshift relation when both populations have the same magnitude limit. We also show that this technique allows the inference of redshift distributions for a population fainter than the reference and we give an estimate of the colour-redshift mapping in this case. This last point is of great interest for future large-redshift surveys which require a complete faint spectroscopic sample.

  3. The-wiZZ: Clustering redshift estimation for everyone

    CERN Document Server

    Morrison, Christopher B; Schmidt, Samuel J; Baldry, Ivan K; Bilicki, Maciej; Choi, Ami; Erben, Thomas; Schneider, Peter

    2016-01-01

    We present The-wiZZ, an open source and user-friendly software for estimating the redshift distributions of photometric galaxies with unknown redshifts by spatially cross-correlating them against a reference sample with known redshifts. The main benefit of The-wiZZ is in separating the angular pair finding and correlation estimation from the computation of the output clustering redshifts allowing anyone to create a clustering redshift for their sample without the intervention of an "expert". It allows the end user of a given survey to select any sub-sample of photometric galaxies with unknown redshifts, match this sample's catalog indices into a value-added data file, and produce a clustering redshift estimation for this sample in a fraction of the time it would take to run all the angular correlations needed to produce a clustering redshift. We show results with this software using photometric data from the Kilo-Degree Survey (KiDS) and spectroscopic redshifts from the Galaxy and Mass Assembly (GAMA) survey ...

  4. The need for accurate redshifts in supernova cosmology

    CERN Document Server

    Calcino, Josh

    2016-01-01

    Recent papers have shown that a small systematic redshift shift ($\\Delta z\\sim 10^{-5}$) in measurements of type Ia supernovae can cause a significant bias ($\\sim$1\\%) in the recovery of cosmological parameters. Such a redshift shift could be caused, for example, by a gravitational redshift due to the density of our local environment. The sensitivity of supernova data to redshift shifts means supernovae make excellent probes of inhomogeneities. We therefore invert the analysis, and try to diagnose the nature of our local gravitational environment by fitting for $\\Delta z$ as an extra free parameter alongside the usual cosmological parameters.

  5. On The Relativity of Redshifts: Does Space Really "Expand"?

    CERN Document Server

    Lewis, Geraint F

    2016-01-01

    In classes on cosmology, students are often told that photons stretch as space expands, but just how physical is this picture? Does space really expand? In this article, we explore the notion of the redshift of light with Einstein's general theory of relativity, showing that the core underpinning principles reveal that redshifts are both simpler and more complex than you might naively think. This has significant implications for the observed redshifting of photons as they travel across the universe, often refereed to as the cosmological redshift, and for the idea of expanding space.

  6. Increased plasma citrulline in mice marks diet-induced obesity and may predict the development of the metabolic syndrome

    NARCIS (Netherlands)

    Sailer, M.; Dahlhoff, C.; Giesbertz, P.; Eidens, M.K.; Wit, de N.J.W.; Rubio-Aliaga, I.; Boekschoten, M.V.; Müller, M.R.; Daniel, H.

    2013-01-01

    Article About the Authors Metrics Comments Related Content Abstract Introduction Results Discussion Materials and Methods Supporting Information Acknowledgments Author Contributions References Reader Comments (0) Figures Abstract In humans, plasma amino acid concentrations of branched-chain amino ac

  7. Intraoperative ICG plasma disappearance rate helps to predict absence of early postoperative complications after orthotopic liver transplantation

    NARCIS (Netherlands)

    Vos, J. J.; Scheeren, T. W. L.; Lukes, D. J.; de Boer, M. T.; Hendriks, H. G. D.; Wietasch, J. K. G.

    2013-01-01

    Early postoperative complications after orthotopic liver transplantation (OLT) are a common problem in intensive care medicine. Adequate assessment of initial graft function remains difficult, however, plasma disaperance rate of indocyanine green (PDRICG) may have an additional diagnostic and

  8. Integrated Prediction and Mitigation Methods of Materials Damage and Lifetime Assessment during Plasma Operation and Various Instabilities in Fusion Devices

    Energy Technology Data Exchange (ETDEWEB)

    Hassanein, Ahmed [Purdue Univ., West Lafayette, IN (United States)

    2015-03-31

    This report describes implementation of comprehensive and integrated models to evaluate plasma material interactions during normal and abnormal plasma operations. The models in full3D simulations represent state-of-the art worldwide development with numerous benchmarking of various tokamak devices and plasma simulators. In addition, significant number of experimental work has been performed in our center for materials under extreme environment (CMUXE) at Purdue to benchmark the effect of intense particle and heat fluxes on plasma-facing components. This represents one-year worth of work and resulted in more than 23 Journal Publications and numerous conferences presentations. The funding has helped several students to obtain their M.Sc. and Ph.D. degrees and many of them are now faculty members in US and around the world teaching and conducting fusion research. Our work has also been recognized through many awards.

  9. The Subaru FMOS galaxy redshift survey (FastSound). IV. New constraint on gravity theory from redshift space distortions at z ˜ 1.4

    Science.gov (United States)

    Okumura, Teppei; Hikage, Chiaki; Totani, Tomonori; Tonegawa, Motonari; Okada, Hiroyuki; Glazebrook, Karl; Blake, Chris; Ferreira, Pedro G.; More, Surhud; Taruya, Atsushi; Tsujikawa, Shinji; Akiyama, Masayuki; Dalton, Gavin; Goto, Tomotsugu; Ishikawa, Takashi; Iwamuro, Fumihide; Matsubara, Takahiko; Nishimichi, Takahiro; Ohta, Kouji; Shimizu, Ikkoh; Takahashi, Ryuichi; Takato, Naruhisa; Tamura, Naoyuki; Yabe, Kiyoto; Yoshida, Naoki

    2016-06-01

    We measure the redshift-space correlation function from a spectroscopic sample of 2783 emission line galaxies from the FastSound survey. The survey, which uses the Subaru Telescope and covers a redshift range of 1.19 parallel and perpendicular to the line of sight and its quadrupole moment. RSD has been extensively used to test general relativity on cosmological scales at z < 1. Adopting a ΛCDM cosmology with the fixed expansion history and no velocity dispersion (σv = 0), and using the RSD measurements on scales above 8 h-1 Mpc, we obtain the first constraint on the growth rate at the redshift, f (z)σ8(z) = 0.482 ± 0.116 at z ˜ 1.4 after marginalizing over the galaxy bias parameter b(z)σ8(z). This corresponds to 4.2 σ detection of RSD. Our constraint is consistent with the prediction of general relativity fσ8 ˜ 0.392 within the 1 σ confidence level. When we allow σv to vary and marginalize over it, the growth rate constraint becomes fσ _8=0.494^{+0.126}_{-0.120}. We also demonstrate that by combining with the low-z constraints on fσ8, high-z galaxy surveys like the FastSound can be useful to distinguish modified gravity models without relying on CMB anisotropy experiments.

  10. Plasma high-mobility group box 1 levels predict mortality after ST-segment elevation myocardial infarction

    DEFF Research Database (Denmark)

    Sørensen, Morten V; Pedersen, Sune; Møgelvang, Rasmus

    2011-01-01

    We evaluated the potential association between plasma high-mobility group box 1 (HMGB1) levels and outcome in patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention.......We evaluated the potential association between plasma high-mobility group box 1 (HMGB1) levels and outcome in patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention....

  11. Redshift and luminosity evolution of the intrinsic alignments of galaxies in Horizon-AGN

    Science.gov (United States)

    Chisari, N.; Laigle, C.; Codis, S.; Dubois, Y.; Devriendt, J.; Miller, L.; Benabed, K.; Slyz, A.; Gavazzi, R.; Pichon, C.

    2016-09-01

    Intrinsic galaxy shape and angular momentum alignments can arise in cosmological large-scale structure due to tidal interactions or galaxy formation processes. Cosmological hydrodynamical simulations have recently come of age as a tool to study these alignments and their contamination to weak gravitational lensing. We probe the redshift and luminosity evolution of intrinsic alignments in Horizon-AGN between z = 0 and 3 for galaxies with an r-band absolute magnitude of Mr ≤ -20. Alignments transition from being radial at low redshifts and high luminosities, dominated by the contribution of ellipticals, to being tangential at high redshift and low luminosities, where discs dominate the signal. This cannot be explained by the evolution of the fraction of ellipticals and discs alone: intrinsic evolution in the amplitude of alignments is necessary. The alignment amplitude of elliptical galaxies alone is smaller in amplitude by a factor of ≃2, but has similar luminosity and redshift evolution as in current observations and in the non-linear tidal alignment model at projected separations of ≳1 Mpc. Alignments of discs are null in projection and consistent with current low-redshift observations. The combination of the two populations yields an overall amplitude a factor of ≃4 lower than observed alignments of luminous red galaxies with a steeper luminosity dependence. The restriction on accurate galaxy shapes implies that the galaxy population in the simulation is complete only to Mr ≤ -20. Higher resolution simulations will be necessary to avoid extrapolation of the intrinsic alignment predictions to the range of luminosities probed by future surveys.

  12. Prediction

    CERN Document Server

    Sornette, Didier

    2010-01-01

    This chapter first presents a rather personal view of some different aspects of predictability, going in crescendo from simple linear systems to high-dimensional nonlinear systems with stochastic forcing, which exhibit emergent properties such as phase transitions and regime shifts. Then, a detailed correspondence between the phenomenology of earthquakes, financial crashes and epileptic seizures is offered. The presented statistical evidence provides the substance of a general phase diagram for understanding the many facets of the spatio-temporal organization of these systems. A key insight is to organize the evidence and mechanisms in terms of two summarizing measures: (i) amplitude of disorder or heterogeneity in the system and (ii) level of coupling or interaction strength among the system's components. On the basis of the recently identified remarkable correspondence between earthquakes and seizures, we present detailed information on a class of stochastic point processes that has been found to be particu...

  13. Clustering in Redshift Space Linear Theory

    CERN Document Server

    Zaroubi, S; Zaroubi, Saleem; Hoffman, Yehuda

    1993-01-01

    The clustering in redshift space is studied here to first order within the framework of gravitational instability. The distortion introduced by the peculiar velocities of galaxies results in anisotropy in the galaxy distribution and mode-mode coupling when analyzed in Fourier space. An exact linear calculation of the full covariance matrix in both the real and Fourier space is presented here. The explicit dependence on $\\Omeg$ and the biasing parameter is calculated and its potential use as a probe of these parameters is analyzed. It is shown that Kaiser's formalism can be applied only to a data set that subtends a small solid angle on the sky, and therefore cannot be used in the case of all sky surveys. The covariance matrix in the real space is calculated explicitly for {\\it CDM} model, where the behavior along and perpendicular to the line of sight is shown.

  14. High-Redshift Astrophysics Using Every Photon

    Science.gov (United States)

    Breysse, Patrick; Kovetz, Ely; Rahman, Mubdi; Kamionkowski, Marc

    2017-01-01

    Large galaxy surveys have dramatically improved our understanding of the complex processes which govern gas dynamics and star formation in the nearby universe. However, we know far less about the most distant galaxies, as existing high-redshift observations can only detect the very brightest sources. Intensity mapping surveys provide a promising tool to access this poorly-studied population. By observing emission lines with low angular resolution, these surveys can make use of every photon in a target line to study faint emitters which are inaccessible using traditional techniques. With upcoming carbon monoxide experiments in mind, I will demonstrate how an intensity map can be used to measure the luminosity function of a galaxy population, and in turn how these measurements will allow us to place robust constraints on the cosmic star formation history. I will then show how cross-correlating CO isotopologue lines will make it possible to study gas dynamics within the earliest galaxies in unprecedented detail.

  15. Magnetic fields during high redshift structure formation

    CERN Document Server

    Schleicher, Dominik R G; Schober, Jennifer; Schmidt, Wolfram; Bovino, Stefano; Federrath, Christoph; Niemeyer, Jens; Banerjee, Robi; Klessen, Ralf S

    2012-01-01

    We explore the amplification of magnetic fields in the high-redshift Universe. For this purpose, we perform high-resolution cosmological simulations following the formation of primordial halos with \\sim10^7 M_solar, revealing the presence of turbulent structures and complex morphologies at resolutions of at least 32 cells per Jeans length. Employing a turbulence subgrid-scale model, we quantify the amount of unresolved turbulence and show that the resulting turbulent viscosity has a significant impact on the gas morphology, suppressing the formation of low-mass clumps. We further demonstrate that such turbulence implies the efficient amplification of magnetic fields via the small-scale dynamo. We discuss the properties of the dynamo in the kinematic and non-linear regime, and explore the resulting magnetic field amplification during primordial star formation. We show that field strengths of \\sim10^{-5} G can be expected at number densities of \\sim5 cm^{-3}.

  16. Observations of the High Redshift Universe

    CERN Document Server

    Ellis, Richard S

    2007-01-01

    (Abridged) In these lectures aimed for non-specialists, I review progress in understanding how galaxies form and evolve. Both the star formation history and assembly of stellar mass can be empirically traced from redshifts z~6 to the present, but how the various distant populations inter-relate and how stellar assembly is regulated by feedback and environmental processes remains unclear. I also discuss how these studies are being extended to locate and characterize the earlier sources beyond z~6. Did early star-forming galaxies contribute significantly to the reionization process and over what period did this occur? Neither theory nor observations are well-developed in this frontier topic but the first results presented here provide important guidance on how we will use more powerful future facilities.

  17. Cosmographic analysis from distance indicator and dynamical redshift drift

    CERN Document Server

    Zhang, Ming-Jian; Xia, Jun-Qing

    2016-01-01

    Cosmography is a model-independent description to the cosmic evolution, but suffers a serious convergence issue in confront of the supernova data, especially for high redshift $z>1$. To ensure data in the convergence radius, $y=z/(1+z)$ redshift was defined. However, discussions about the usefulness of $y$-redshift and the leading cause of the issue are commonly absent. In the present paper, we study the cosmography in both $z$ and $y$ redshift using the supernova and mock redshift drift data. By introducing the bias-variance tradeoff, we reveal that the large bias square between cosmography and Union2.1 supernova data is the "chief culprit" of convergence issue. Moreover, expansion up to higher order and introduction of the $y$-redshift both are not effective to reconcile this contradiction. Minimizing risk, it suggests that Taylor expansion up to the second term is a better choice for available supernova data. Forecast from future supernova data and redshift drift shows that redshift drift can give much tig...

  18. Gamma photometric redshifts for long gamma-ray bursts

    CERN Document Server

    Bagoly, Z; Mészáros, A; Mészáros, P; Horváth, I; Balázs, L G; Vavrek, R

    2003-01-01

    It is known that the soft tail of the gamma-ray bursts' spectra show excesses from the exact power-law dependence. In this article we show that this departure can be detected in the peak flux ratios of different BATSE DISCSC energy channels. This effect allows to estimate the redshift of the bright long gamma-ray bursts in the BATSE Catalog. A verification of these redshifts is obtained for the 8 GRB which have both BATSE DISCSC data and measured optical spectroscopic redshifts. There is good correlation between the measured and esti redshifts, and the average error is $\\Delta z \\approx 0.33$. The method is similar to the photometric redshift estimation of galaxies in the optical range, hence it can be called as "gamma photometric redshift estimation". The estimated redshifts for the long bright gamma-ray bursts are up to $z \\simeq 4$. For the the faint long bursts - which should be up to $z \\simeq 20$ - the redshifts cannot be determined unambiguously with this method.

  19. Probing the sparse tails of redshift distributions with Voronoi tessellations

    Science.gov (United States)

    Granett, B. R.

    2017-01-01

    We introduce an empirical galaxy photometric redshift algorithm based upon the Voronoi tessellation density estimator in the space of redshift and photometric parameters. Our aim is to use sparse survey datasets to estimate the full shape of the redshift distribution that is defined by the degeneracies in galaxy photometric properties and redshift. We describe the algorithm implementation and provide a proof of concept using the first public data release from the VIMOS Public Extragalactic Redshift Survey (VIPERS PDR-1). We validate the method by comparing against the standard empirical redshift distribution code Trees for Photo-Z (TPZ) on both mock and real data. We find that the Voronoi tessellation algorithm accurately recovers the full shape of the redshift distribution quantified by its second moment and inferred redshift confidence intervals. The analysis allows us to properly account for galaxies in the tails of the distributions that would otherwise be classified as catastrophic outliers. The source code is publicly available at http://bitbucket.org/bengranett/tailz.

  20. Note on Redshift Distortion in Fourier Space

    Institute of Scientific and Technical Information of China (English)

    Yan-Chuan Cai; Jun Pan

    2007-01-01

    We explore features of redshift distortion in Fourier analysis of N-body simulations.The phases of the Fourier modes of dark matter density fluctuation are generally shifted by the peculiar motion along the line of sight, the induced phase shift is stochastic and has a probability distribution function (PDF) that is symmetric about the peak at zero shift and whose exact shape depends on the wave vector, except on very large scales where phases are invariant by linear perturbation theory. Analysis of the phase shifts motivates our phenomenological models for the bispectrum in redshift space. Comparison with simulations shows that our toy models are very successful in modeling bispectrum of equilateral and isosceles triangles at large scales. In the second part we compare the monopole of the power spectrum and bispectrum in the radial and plane-parallel distortion to test the plane-parallel approximation.We confirm the results of Scoccimarro that difference of power spectrum is at the level of 10%, and, in the reduced bispectrum, the difference is as small as a few percent. However, on the plane perpendicular to the line of sight of kz = 0, the difference in power spectrum between the radial and plane-parallel approximation can be more than ~ 10%, and even worse on very small scales. Such difference is prominent for bispectrum, especially for configurations of tilted triangles. Non-Gaussian signals under the radial distortion on small scales are systematically biased downside than are in the plane-parallel approximation, with amplitudes depending on the opening angle of the sample point to the observer. This observation gives warning to the practice of using the power spectrum and bispectrum measured on the kz = 0 plane as estimates of the real space statistics.

  1. The Rise and Fall of the Star Formation Histories of Blue Galaxies at Redshifts 0.2 < z < 1.4

    Science.gov (United States)

    Pacifici, Camilla; Kassin, Susan A.; Weiner, Benjamin; Charlot, Stéphane; Gardner, Jonathan P.

    2013-01-01

    Popular cosmological scenarios predict that galaxies form hierarchically from the merger of many progenitors, each with their own unique star formation history (SFH). We use a sophisticated approach to constrain the SFHs of 4517 blue (presumably star-forming) galaxies with spectroscopic redshifts in the range 0.2 declining SFHs widely used to interpret observed galaxy spectral energy distributions may not be appropriate to constrain the physical parameters of star-forming galaxies at intermediate redshifts.

  2. Dusty Star Forming Galaxies and Supermassive Black Holes at High Redshifts: In- Situ Coevolution

    Science.gov (United States)

    Mancuso, Claudia

    2016-10-01

    We have exploited the continuity equation approach and the star-formation timescales derived from the observed 'main sequence' relation (Star Formation Rate vs Stellar Mass), to show that the observed high abundance of galaxies with stellar masses ≥ a few 10^10 M⊙ at redshift z ≥ 4 implies the existence of a galaxy population featuring large star formation rates (SFRs) ψ ≥ 10^2 M⊙ yr^-1 in heavily dust-obscured conditions. These galaxies constitute the high-redshift counterparts of the dusty star-forming population already surveyed for z ≤ 3 in the Far-InfraRed (FIR) band by the Herschel space observatory. We work out specific predictions for the evolution of the corresponding stellar mass and SFR functions out to z ∼10, elucidating that the number density at z ≤ 8 for SFRs ψ ≥ 30 M⊙ yr^-1 cannot be estimated relying on the UltraViolet (UV) luminosity function alone, even when standard corrections for dust extinction based on the UV slope are applied. We compute the number counts and redshift distributions (including galaxy-scale gravitational lensing) of this galaxy population, and show that current data from AzTEC-LABOCA, SCUBA-2 and ALMA-SPT surveys are already digging into it. We substantiate how an observational strategy based on a color preselection in the far-IR or (sub-)mm band with Herschel and SCUBA-2, supplemented by photometric data via on-source observations with ALMA, can allow to reconstruct the bright end of the SFR functions out to z ≤ 8. In parallel, such a challenging task can be managed by exploiting current UV surveys in combination with (sub-)mm observations by ALMA and NIKA2. The same could be done with radio observations by SKA and its precursors. In particular we have worked out predictions for the radio counts of star-forming galaxies down to nJy levels, along with redshift distributions down to the detection limits of the phase 1 Square Kilometer Array MID telescope (SKA1-MID) and of its precursors. To do that we

  3. How Accurately Can We Measure Galaxy Environment at High Redshift Using Only Photometric Redshifts?

    Science.gov (United States)

    Florez, Jonathan; Jogee, Shardha; Sherman, Sydney; Papovich, Casey J.; Finkelstein, Steven L.; Stevans, Matthew L.; Kawinwanichakij, Lalitwadee; Ciardullo, Robin; Gronwall, Caryl; SHELA/HETDEX

    2017-06-01

    We use a powerful synergy of six deep photometric surveys (Herschel SPIRE, Spitzer IRAC, NEWFIRM K-band, DECam ugriz, and XMM X-ray) and a future optical spectroscopic survey (HETDEX) in the Stripe 82 field to study galaxy evolution during the 1.9 nearest neighbor densities, and galaxy counts within some projected aperture) at different photometric redshifts to cosmological simulations in order to quantify the uncertainty in our estimates of environment. We also explore how robustly one can recover the variation of galaxy properties with environment, when using only photometric redshifts. In the era of large photometric surveys, this work has broad implications for studies addressing the impact of environment on galaxy evolution at early cosmic epochs. We acknowledge support from NSF grants AST-1614798, AST-1413652 and NSF GRFP grant DGE-1610403.

  4. Rotating shallow water modeling of planetary,astrophysical and plasma vortical structures (plasma transport across a magnetic field,model of the jupiter's GRS, prediction of existence of giant vortices in spiral galaxies

    Directory of Open Access Journals (Sweden)

    M. V. Nezlin

    1999-01-01

    Full Text Available Three kinds of results have been described in this paper. Firstly, an experimental study of the Rossby vortex meridional drift on the rotating shallow water has been carried out. Owing to the stringent physical analogy between the Rossby vortices and drift vortices in the magnetized plasma, the results obtained have allowed one to make a conclusion that the transport rate of the plasma, trapped by the drift vortices, across the magnetic field is equivalent to the “gyro-Bohm” diffusion coefficient. Secondly, a model of big vortices of the type of the Great Red Spot of Jupiter, dominating in the atmospheres of the outer planets, has been produced. Thirdly, the rotating shallow water modeling has been carried out of the hydrodynamical generation mechanism of spiral structures in galaxies. Trailing spiral waves of various azimuthal modes, generated by a shear flow between fast rotating “nucleus” and slow rotating periphery, were produced. The spirals are similar to those existing in the real galaxies. The hydrodynamical concept of the spiral structure formation in galaxies has been substantiated. Strong anticyclonic vortices between the spiral arms of the structures under study have been discovered for the first time. The existence of analogous vortices in real galaxies has been predicted. (This prediction has been reliably confirmed recently in special astronomical observations, carried out on the basis of the mentioned laboratory modeling and the prediction made – see the paper by A. Fridman et al. (Astrophysics and Space Science, 1997, 252, 115.

  5. Galaxy clustering with photometric surveys using PDF redshift information

    Science.gov (United States)

    Asorey, J.; Carrasco Kind, M.; Sevilla-Noarbe, I.; Brunner, R. J.; Thaler, J.

    2016-06-01

    Photometric surveys produce large-area maps of the galaxy distribution, but with less accurate redshift information than is obtained from spectroscopic methods. Modern photometric redshift (photo-z) algorithms use galaxy magnitudes, or colours, that are obtained through multiband imaging to produce a probability density function (PDF) for each galaxy in the map. We used simulated data to study the effect of using different photo-z estimators to assign galaxies to redshift bins in order to compare their effects on angular clustering and galaxy bias measurements. We found that if we use the entire PDF, rather than a single-point (mean or mode) estimate, the deviations are less biased, especially when using narrow redshift bins. When the redshift bin widths are Δz = 0.1, the use of the entire PDF reduces the typical measurement bias from 5 per cent, when using single point estimates, to 3 per cent.

  6. Galaxy clustering with photometric surveys using PDF redshift information

    CERN Document Server

    Asorey, J; Sevilla-Noarbe, I; Brunner, R J; Thaler, J

    2016-01-01

    Photometric surveys produce large-area maps of the galaxy distribution, but with less accurate redshift information than is obtained from spectroscopic methods. Modern photometric redshift (photo-z) algorithms use galaxy magnitudes, or colors, that are obtained through multi-band imaging to produce a probability density function (PDF) for each galaxy in the map. We used simulated data to study the effect of using different photo-z estimators to assign galaxies to redshift bins in order to compare their effects on angular clustering and galaxy bias measurements. We found that if we use the entire PDF, rather than a single-point (mean or mode) estimate, the deviations are less biased, especially when using narrow redshift bins. When the redshift bin widths are $\\Delta z=0.1$, the use of the entire PDF reduces the typical measurement bias from 5%, when using single point estimates, to 3%.

  7. Calibrating photometric redshift distributions with cross-correlations

    CERN Document Server

    Schulz, A E

    2009-01-01

    The next generation of proposed galaxy surveys will increase the number of galaxies with photometric redshifts by two orders of magnitude, drastically expanding both redshift range and detection threshold from the current state of the art. Obtaining spectra for a fair sub-sample of this new data could be cumbersome and expensive. However, adequate calibration of the true redshift distribution of galaxies is vital to tapping the potential of these surveys. We examine a promising alternative to direct spectroscopic follow up: calibration of the redshift distribution of photometric galaxies via cross-correlation with an overlapping spectroscopic survey whose members trace the same density field. We review the theory, develop a pipeline, apply it to mock data from N-body simulations, and examine the properties of this redshift distribution estimator. We demonstrate that the method is effective, but the estimator is weakened by two factors. 1) The correlation function of the spectroscopic sample must be measured i...

  8. High-Redshift Radio Galaxies from Deep Fields

    Indian Academy of Sciences (India)

    C. H. Ishwara-Chandra; S. K. Sirothia; Y. Wadadekar; S. Pal

    2011-12-01

    Most of the radio galaxies with > 3 have been found using the red-shift spectral index correlation.We have started a programme with the Giant Metrewave Radio Telescope (GMRT) to exploit this correlation at flux density levels about 100 times deeper than the known high-redshift radio galaxies, with an aim to detect candidate high-redshift radio galaxies. Here we present results from the deep 150 MHz observations of LBDS-Lynx field, which has been imaged at 327, 610 and 1412 MHz with the Westerbork Synthesis Radio Telescope (WSRT) and at 1400 and 4860 MHz with the Very Large Array (VLA). We find about 150 radio sources with spectra steeper than 1. About two-thirds of these are not detected in Sloan Digital Sky Survey (SDSS), hence are strong candidate high-redshift radio galaxies, which need to be further explored with deep infra-red imaging and spectroscopy to estimate the red-shift.

  9. An Analysis of gravitational redshift from rotating body

    CERN Document Server

    Dubey, Anuj Kumar

    2014-01-01

    Gravitational redshift is generally calculated without considering the rotation of a body. Neglecting the rotation, the geometry of space time can be described by using the spherically symmetric Schwarzschild geometry. Rotation has great effect on general relativity, which gives new challenges on gravitational redshift. When rotation is taken into consideration spherical symmetry is lost and off diagonal terms appear in the metric. The geometry of space time can be then described by using the solutions of Kerr family. In the present paper we discuss the gravitational redshift for rotating body by using Kerr metric. The numerical calculations has been done under Newtonian approximation of angular momentum. It has been found that the value of gravitational redshift is influenced by the direction of spin of central body and also on the position (latitude) on the central body at which the photon is emitted. The variation of gravitational redshift from equatorial to non - equatorial region has been calculated and ...

  10. Constraints on the $\\Lambda$CDM model with redshift tomography

    CERN Document Server

    Cai, Rong-Gen; Tang, Bo

    2013-01-01

    Recently released Planck data favor a lower value of the Hubble constant and a higher value of the fraction matter density in the standard $\\Lambda$CDM model, which are discrepant with some of the low-redshift measurements. Within the context of this cosmology, we examine the consistency of the estimated values for the Hubble constant and fraction matter density with redshift tomography. Using the SNe Ia, Hubble parameter, BAO and CMB data, which are divided into three bins, we find no statistical evidence for any tension in the three redshift bins, although there exists a 1.4$\\sigma$ deviation of the Hubble constant in the middle redshift from the one in the high redshift bin.

  11. Gravitational redshift and asymmetric redshift-space distortions for stacked clusters

    CERN Document Server

    Cai, Yan-Chuan; Cole, Shaun; Frenk, Carlos

    2016-01-01

    We derive the expression for the observed redshift in the weak field limit in the observer's past light cone, including all relativistic terms up to second order in velocity. We then apply it to compute the cluster-galaxy cross-correlation functions (CGCF) using N-body simulations. The CGCF is asymmetric along the line of sight (LOS) owing to the presence of the small second order terms such as the gravitational redshift (GRedshift). We identify two systematics in the modelling of the GRedshift signal in stacked clusters. First, it is affected by the morphology of dark matter haloes and the large-scale cosmic-web. The non-spherical distribution of galaxies around the central halo and the presence of neighbouring clusters systematically reduce the GRedshift signal. This bias is approximately 20% for $M_{\\rm min}\\simeq 10^{14} {\\rm M_{\\odot}}/h$, and is more than 50% for haloes with $M_{\\rm min}\\simeq 2\\times 10^{13} {\\rm M_{\\odot}}/h$ at $r>$4 Mpc/$h$. Second, the best-fit gravitational redshift profiles as we...

  12. The Merger Rate to Redshift One from Kinematic Pairs Caltech Faint Galaxy Redshift Survey XI

    CERN Document Server

    Carlberg, R G; Patton, D R; Blandford, R D; Hogg, D W; Yee, H K C; Morris, S L; Lin, H; Cowie, L L; Hu, E; Songaila, A; Cohen, Judith G.; Blandford, Roger; Hogg, David W.; Cowie, Lennox L.; Hu, Esther; Songaila, Antoinette

    2000-01-01

    The rate of mass accumulation due to galaxy merging depends on the mass, density, and velocity distribution of galaxies in the near neighborhood of a host galaxy. The fractional luminosity in kinematic pairs combines all of these effects in a single estimator which is relatively insensitive to population evolution. Here we use a k-corrected and evolution compensated volume-limited sample drawing about 300 redshifts from CFGRS and 3000 from CNOC2 to measure the rate and redshift evolution of merging. We identify kinematic pairs with projected separations less than either 50 or 100 \\hkpc and rest-frame velocity differences of less than 1000\\kms. The fractional luminosity in pairs is modeled as f_L(Delta v,r_p,M_r^{ke})(1+z)^{m_L} where [f_L,m_L] are [0.14+/-0.07,0+/-1.4] and [0.37+/-0.7,0.1+/-0.5] for r_p= 0.2 M*) is 0.02+/-0.01(1+z)^{0.1+/-0.5} M*~Gyr^{-1}. Present day high-luminosity galaxies therefore have accreted approximately 0.15M* of their mass over the approximately 7 Gyr to redshift one. (abridged)

  13. Modulation of plasma metabolite biomarkers of MAPK pathway with the MEK inhibitor RO4987655: pharmacodynamic and predictive potential in metastatic melanoma.

    Science.gov (United States)

    Ang, Joo Ern; Pal, Akos; Asad, Yasmin J; Henley, Alan T; Valenti, Melanie; Box, Gary; de Haven Brandon, Alexis; Revell, Victoria; Skene, Debra J; Venturi, Miro; Rueger, Ruediger; Meresse, Valerie; Eccles, Suzanne A; de Bono, Johann S; Kaye, Stanley B; Workman, Paul; Banerji, Udai; Raynaud, Florence I

    2017-06-21

    MAPK pathway activation is frequently observed in human malignancies, including melanoma, and is associated with sensitivity to MEK inhibition and changes in cellular metabolism. Using quantitative mass spectrometry-based metabolomics, we identified in preclinical models 21 plasma metabolites including amino acids, propionylcarnitine, phosphatidylcholines and sphingomyelins that were significantly altered in two B-RAF mutant melanoma xenografts and that were reversed following a single dose of the potent and selective MEK inhibitor RO4987655. Treatment of non-tumour bearing animals and mice bearing the PTEN null U87MG human glioblastoma xenograft elicited plasma changes only in amino acids and propionylcarnitine. In patients with advanced melanoma treated with RO4987655, on-treatment changes of amino acids were observed in patients with disease progression and not in responders. In contrast, changes in phosphatidylcholines and sphingomyelins were observed in responders. Furthermore, pre-treatment levels of 7 lipids identified in the preclinical screen were statistically significantly able to predict objective responses to RO4987655. The RO4987655 treatment-related changes were greater than baseline physiological variability in non-treated individuals. This study provides evidence of a translational exo-metabolomic plasma readout predictive of clinical efficacy together with pharmacodynamic utility following treatment with a signal transduction inhibitor. Copyright ©2017, American Association for Cancer Research.

  14. Development of a Rat Plasma and Brain Extracellular Fluid Pharmacokinetic Model for Bupropion and Hydroxybupropion Based on Microdialysis Sampling, and Application to Predict Human Brain Concentrations.

    Science.gov (United States)

    Cremers, Thomas I F H; Flik, Gunnar; Folgering, Joost H A; Rollema, Hans; Stratford, Robert E

    2016-05-01

    Administration of bupropion [(±)-2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-one] and its preformed active metabolite, hydroxybupropion [(±)-1-(3-chlorophenyl)-2-[(1-hydroxy-2-methyl-2-propanyl)amino]-1-propanone], to rats with measurement of unbound concentrations by quantitative microdialysis sampling of plasma and brain extracellular fluid was used to develop a compartmental pharmacokinetics model to describe the blood-brain barrier transport of both substances. The population model revealed rapid equilibration of both entities across the blood-brain barrier, with resultant steady-state brain extracellular fluid/plasma unbound concentration ratio estimates of 1.9 and 1.7 for bupropion and hydroxybupropion, respectively, which is thus indicative of a net uptake asymmetry. An overshoot of the brain extracellular fluid/plasma unbound concentration ratio at early time points was observed with bupropion; this was modeled as a time-dependent uptake clearance of the drug across the blood-brain barrier. Translation of the model was used to predict bupropion and hydroxybupropion exposure in human brain extracellular fluid after twice-daily administration of 150 mg bupropion. Predicted concentrations indicate that preferential inhibition of the dopamine and norepinephrine transporters by the metabolite, with little to no contribution by bupropion, would be expected at this therapeutic dose. Therefore, these results extend nuclear imaging studies on dopamine transporter occupancy and suggest that inhibition of both transporters contributes significantly to bupropion's therapeutic efficacy.

  15. Changes in plasma chemokine C-C motif ligand 2 levels during treatment with eicosapentaenoic acid predict outcome in patients undergoing surgery for colorectal cancer liver metastasis

    Science.gov (United States)

    Volpato, Milene; Perry, Sarah L; Marston, Gemma; Ingram, Nicola; Cockbain, Andrew J.; Burghel, Heather; Jake, Mann; Lowes, David; Wilson, Erica; Droop, Alastair; Randerson-Moor, Juliette; Coletta, P Louise; Hull, Mark A

    2016-01-01

    The mechanism of the anti-colorectal cancer (CRC) activity of the omega-3 fatty acid eicosapentaenoic acid (EPA) is not understood. We tested the hypothesis that EPA reduces expression of chemokine C-C motif ligand 2 (CCL2), a pro-inflammatory chemokine with known roles in metastasis. We measured CCL2 in clinical samples from a randomized trial of EPA in patients undergoing liver surgery for CRC liver metastasis (LM) and preclinical models. Genome-wide transcriptional profiling of tumors from EPA-treated patients was performed. EPA decreased CCL2 synthesis by CRC cells in a dose-dependent manner. CCL2 was localized to malignant epithelial cells in human CRCLM. EPA did not reduce CCL2 content in human or mouse tumors compare to control. However, EPA treatment was associated with decreased plasma CCL2 levels compared with controls (P=0.04). Reduction in plasma CCL2 following EPA treatment predicted improved disease-free survival (HR 0.32; P=0.003). Lack of ‘CCL2 response’ was associated with a specific CRCLM gene expression signature. In conclusion, reduction in plasma CCL2 in patients with CRCLM treated with EPA predicts better clinical outcome and a specific tumor gene expression profile. Further work is needed to validate CCL2 as a therapeutic response biomarker for omega-3 fatty acid treatment of CRC patients. PMID:27058904

  16. Pentraxin 3 plasma levels at graft-versus-host disease onset predict disease severity and response to therapy in children given haematopoietic stem cell transplantation.

    Science.gov (United States)

    Dander, Erica; De Lorenzo, Paola; Bottazzi, Barbara; Quarello, Paola; Vinci, Paola; Balduzzi, Adriana; Masciocchi, Francesca; Bonanomi, Sonia; Cappuzzello, Claudia; Prunotto, Giulia; Pavan, Fabio; Pasqualini, Fabio; Sironi, Marina; Cuccovillo, Ivan; Leone, Roberto; Salvatori, Giovanni; Parma, Matteo; Terruzzi, Elisabetta; Pagni, Fabio; Locatelli, Franco; Mantovani, Alberto; Fagioli, Franca; Biondi, Andrea; Garlanda, Cecilia; Valsecchi, Maria Grazia; Rovelli, Attilio; D'Amico, Giovanna

    2016-12-13

    Acute Graft-versus-Host Disease (GvHD) remains a major complication of allogeneic haematopoietic stem cell transplantation, with a significant proportion of patients failing to respond to first-line systemic corticosteroids. Reliable biomarkers predicting disease severity and response to treatment are warranted to improve its management. Thus, we sought to determine whether pentraxin 3 (PTX3), an acute-phase protein produced locally at the site of inflammation, could represent a novel acute GvHD biomarker. Using a murine model of the disease, we found increased PTX3 plasma levels after irradiation and at GvHD onset. Similarly, plasma PTX3 was enhanced in 115 pediatric patients on day of transplantation, likely due to conditioning, and at GvHD onset in patients experiencing clinical symptoms of the disease. PTX3 was also found increased in skin and colon biopsies from patients with active disease. Furthermore, PTX3 plasma levels at GvHD onset were predictive of disease outcome since they resulted significantly higher in both severe and therapy-unresponsive patients. Multiple injections of rhPTX3 in the murine model of GvHD did not influence the disease course. Taken together, our results indicate that PTX3 constitutes a biomarker of GvHD severity and therapy response useful to tailor treatment intensity according to early risk-stratification of GvHD patients.

  17. Pentraxin 3 plasma levels at graft-versus-host disease onset predict disease severity and response to therapy in children given haematopoietic stem cell transplantation

    Science.gov (United States)

    Dander, Erica; De Lorenzo, Paola; Bottazzi, Barbara; Quarello, Paola; Vinci, Paola; Balduzzi, Adriana; Masciocchi, Francesca; Bonanomi, Sonia; Cappuzzello, Claudia; Prunotto, Giulia; Pavan, Fabio; Pasqualini, Fabio; Sironi, Marina; Cuccovillo, Ivan; Leone, Roberto; Salvatori, Giovanni; Parma, Matteo; Terruzzi, Elisabetta; Pagni, Fabio; Locatelli, Franco; Mantovani, Alberto; Fagioli, Franca; Biondi, Andrea; Garlanda, Cecilia; Valsecchi, Maria Grazia; Rovelli, Attilio; D'Amico, Giovanna

    2016-01-01

    Acute Graft-versus-Host Disease (GvHD) remains a major complication of allogeneic haematopoietic stem cell transplantation, with a significant proportion of patients failing to respond to first-line systemic corticosteroids. Reliable biomarkers predicting disease severity and response to treatment are warranted to improve its management. Thus, we sought to determine whether pentraxin 3 (PTX3), an acute-phase protein produced locally at the site of inflammation, could represent a novel acute GvHD biomarker. Using a murine model of the disease, we found increased PTX3 plasma levels after irradiation and at GvHD onset. Similarly, plasma PTX3 was enhanced in 115 pediatric patients on day of transplantation, likely due to conditioning, and at GvHD onset in patients experiencing clinical symptoms of the disease. PTX3 was also found increased in skin and colon biopsies from patients with active disease. Furthermore, PTX3 plasma levels at GvHD onset were predictive of disease outcome since they resulted significantly higher in both severe and therapy-unresponsive patients. Multiple injections of rhPTX3 in the murine model of GvHD did not influence the disease course. Taken together, our results indicate that PTX3 constitutes a biomarker of GvHD severity and therapy response useful to tailor treatment intensity according to early risk-stratification of GvHD patients. PMID:27893415

  18. A PARAMETRIC STUDY OF POSSIBLE SOLUTIONS TO THE HIGH-REDSHIFT OVERPRODUCTION OF STARS IN MODELED DWARF GALAXIES

    Energy Technology Data Exchange (ETDEWEB)

    White, Catherine E. [Department of Physics and Astronomy, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218 (United States); Somerville, Rachel S. [Department of Physics and Astronomy, Rutgers University, 136 Frelinghuysen Road, Piscataway, NJ 08854 (United States); Ferguson, Henry C. [Space Telescope Science Institute, 3700 San Martin Drive, Baltimore, MD 21218 (United States)

    2015-02-01

    Both numerical hydrodynamic and semi-analytic cosmological models of galaxy formation struggle to match observed star formation histories of galaxies in low-mass halos (M {sub H} ≲ 10{sup 11} M {sub ☉}), predicting more star formation at high redshift and less star formation at low redshift than observed. The fundamental problem is that galaxies' gas accretion and star formation rates are too closely coupled in the models: the accretion rate largely drives the star formation rate. Observations point to gas accretion rates that outpace star formation at high redshift, resulting in a buildup of gas and a delay in star formation until lower redshifts. We present three empirical adjustments of standard recipes in a semi-analytic model motivated by three physical scenarios that could cause this decoupling: (1) the mass-loading factors of outflows driven by stellar feedback may have a steeper dependence on halo mass at earlier times, (2) the efficiency of star formation may be lower in low-mass halos at high redshift, and (3) gas may not be able to accrete efficiently onto the disk in low-mass halos at high redshift. These new recipes, once tuned, better reproduce the evolution of f {sub *}≡ M {sub *}/M {sub H} as a function of halo mass as derived from abundance matching over redshifts z = 0 to 3, though they have different effects on cold gas fractions, star formation rates, and metallicities. Changes to gas accretion and stellar-driven winds are promising, while direct modification of the star formation timescale requires drastic measures that are not physically well motivated.

  19. Long Gamma-Ray Bursts without Visible Supernovae A Case Study of Redshift Estimators and Alleged Novel Objects

    CERN Document Server

    Dado, Shlomo; De Rújula, A; Plaga, Rainer

    2008-01-01

    It has been argued that the observational limits on a supernova (SN) associated with GRB 060614 convincingly exclude a SN akin to SN 1998bw as its originator and provide evidence for a new class of long-duration GRBs. We discuss this issue in the contexts of indirect "redshift estimators" and of the fireball and cannonball models of GRBs. The latter explains the unusual properties of GRB 060614: at its debated but favored low redshift (0.125), they are predicted, as opposed to exceptional, if the associated core-collapse SN is of a recently discovered, very faint type. We take the occasion to discuss the association between GRBs and SNe.

  20. Machine-z: Rapid Machine Learned Redshift Indicator for Swift Gamma-ray Bursts

    CERN Document Server

    Ukwatta, T N; Gehrels, N

    2015-01-01

    Studies of high-redshift gamma-ray bursts (GRBs) provide important information about the early Universe such as the rates of stellar collapsars and mergers, the metallicity content, constraints on the re-ionization period, and probes of the Hubble expansion. Rapid selection of high-z candidates from GRB samples reported in real time by dedicated space missions such as Swift is the key to identifying the most distant bursts before the optical afterglow becomes too dim to warrant a good spectrum. Here we introduce "machine-z", a redshift prediction algorithm and a "high-z" classifier for Swift GRBs based on machine learning. Our method relies exclusively on canonical data commonly available within the first few hours after the GRB trigger. Using a sample of 284 bursts with measured redshifts, we trained a randomized ensemble of decision trees (random forest) to perform both regression and classification. Cross-validated performance studies show that the correlation coefficient between machine-z predictions and ...

  1. Detecting Massive, High-Redshift Galaxy Clusters Using the Thermal Sunyaev-Zel'dovich Effect

    Science.gov (United States)

    Adams, Carson; Steinhardt, Charles L.; Loeb, Abraham; Karim, Alexander; Staguhn, Johannes; Erler, Jens; Capak, Peter L.

    2017-01-01

    We develop the thermal Sunyaev-Zel'dovich (SZ) effect as a direct astrophysical measure of the mass distribution of dark matter halos. The SZ effect increases with cosmological distance, a unique astronomical property, and is highly sensitive to halo mass. We find that this presents a powerful methodology for distinguishing between competing models of the halo mass function distribution, particularly in the high-redshift domain just a few hundred million years after the Big Bang. Recent surveys designed to probe this epoch of initial galaxy formation such as CANDELS and SPLASH report an over-abundance of highly massive halos as inferred from stellar ultraviolet (UV) luminosities and the stellar mass to halo mass ratio estimated from nearby galaxies. If these UV luminosity to halo mass relations hold to high-redshift, observations estimate several orders of magnitude more highly massive halos than predicted by hierarchical merging and the standard cosmological paradigm. Strong constraints on the masses of these galaxy clusters are essential to resolving the current tension between observation and theory. We conclude that detections of thermal SZ sources are plausible at high-redshift only for the halo masses inferred from observation. Therefore, future SZ surveys will provide a robust determination between theoretical and observational predictions.

  2. Average and dispersion of the luminosity-redshift relation in the concordance model

    Energy Technology Data Exchange (ETDEWEB)

    Ben-Dayan, I. [DESY Hamburg (Germany). Theory Group; Gasperini, M. [Bari Univ. (Italy). Dipt. di Fisica; Istituto Nazionale di Fisica Nucleare, Bari (Italy); Marozzi, G. [College de France, 75 - Paris (France); Geneve Univ. (Switzerland). Dept. de Physique Theorique and CAP; Nugier, F. [Ecole Normale Superieure CNRS, Paris (France). Laboratoire de Physique Theorique; Veneziano, G. [College de France, 75 - Paris (France); CERN, Geneva (Switzerland). Physics Dept.; New York Univ., NY (United States). Dept. of Physics

    2013-03-15

    Starting from the luminosity-redshift relation recently given up to second order in the Poisson gauge, we calculate the effects of the realistic stochastic background of perturbations of the so-called concordance model on the combined light-cone and ensemble average of various functions of the luminosity distance, and on their variance, as functions of redshift. We apply a gauge-invariant light-cone averaging prescription which is free from infrared and ultraviolet divergences, making our results robust with respect to changes of the corresponding cutoffs. Our main conclusions, in part already anticipated in a recent letter for the case of a perturbation spectrum computed in the linear regime, are that such inhomogeneities not only cannot avoid the need for dark energy, but also cannot prevent, in principle, the determination of its parameters down to an accuracy of order 10{sup -3} - 10{sup -5}, depending on the averaged observable and on the regime considered for the power spectrum. However, taking into account the appropriate corrections arising in the non-linear regime, we predict an irreducible scatter of the data approaching the 10% level which, for limited statistics, will necessarily limit the attainable precision. The predicted dispersion appears to be in good agreement with current observational estimates of the distance-modulus variance due to Doppler and lensing effects (at low and high redshifts, respectively), and represents a challenge for future precision measurements.

  3. Average and dispersion of the luminosity-redshift relation in the concordance model

    Energy Technology Data Exchange (ETDEWEB)

    Ben-Dayan, I. [DESY Hamburg (Germany). Theory Group; Gasperini, M. [Bari Univ. (Italy). Dipt. di Fisica; Istituto Nazionale di Fisica Nucleare, Bari (Italy); Marozzi, G. [College de France, 75 - Paris (France); Geneve Univ. (Switzerland). Dept. de Physique Theorique and CAP; Nugier, F. [Ecole Normale Superieure CNRS, Paris (France). Laboratoire de Physique Theorique; Veneziano, G. [College de France, 75 - Paris (France); CERN, Geneva (Switzerland). Physics Dept.; New York Univ., NY (United States). Dept. of Physics

    2013-03-15

    Starting from the luminosity-redshift relation recently given up to second order in the Poisson gauge, we calculate the effects of the realistic stochastic background of perturbations of the so-called concordance model on the combined light-cone and ensemble average of various functions of the luminosity distance, and on their variance, as functions of redshift. We apply a gauge-invariant light-cone averaging prescription which is free from infrared and ultraviolet divergences, making our results robust with respect to changes of the corresponding cutoffs. Our main conclusions, in part already anticipated in a recent letter for the case of a perturbation spectrum computed in the linear regime, are that such inhomogeneities not only cannot avoid the need for dark energy, but also cannot prevent, in principle, the determination of its parameters down to an accuracy of order 10{sup -3} - 10{sup -5}, depending on the averaged observable and on the regime considered for the power spectrum. However, taking into account the appropriate corrections arising in the non-linear regime, we predict an irreducible scatter of the data approaching the 10% level which, for limited statistics, will necessarily limit the attainable precision. The predicted dispersion appears to be in good agreement with current observational estimates of the distance-modulus variance due to Doppler and lensing effects (at low and high redshifts, respectively), and represents a challenge for future precision measurements.

  4. ALMA redshifts of millimeter-selected galaxies from the SPT survey: The redshift distribution of dusty star-forming galaxies

    CERN Document Server

    Weiss, A; Marrone, D P; Vieira, J D; Aguirre, J E; Aird, K A; Aravena, M; Ashby, M L N; Bayliss, M; Benson, B A; Bethermin, M; Biggs, A D; Bleem, L E; Bock, J J; Bothwell, M; Bradford, C M; Brodwin, M; Carlstrom, J E; Chang, C L; Chapman, S C; Crawford, T M; Crites, A T; de Haan, T; Dobbs, M A; Downes, T P; Fassnacht, C D; George, E M; Gladders, M D; Gonzalez, A H; Greve, T R; Halverson, N W; Hezaveh, Y D; High, F W; Holder, G P; Holzapfel, W L; Hoover, S; Hrubes, J D; Husband, K; Keisler, R; Lee, A T; Leitch, E M; Lueker, M; Luong-Van, D; Malkan, M; McIntyre, V; McMahon, J J; Mehl, J; Menten, K M; Meyer, S S; Murphy, E J; Padin, S; Plagge, T; Reichardt, C L; Rest, A; Rosenman, M; Ruel, J; Ruhl, J E; Schaffer, K K; Shirokoff, E; Spilker, J S; Stalder, B; Staniszewski, Z; Stark, A A; Story, K; Vanderlinde, K; Welikala, N; Williamson, R

    2013-01-01

    Using the Atacama Large Millimeter/submillimeter Array (ALMA), we have conducted a blind redshift survey in the 3 mm atmospheric transmission window for 26 strongly lensd dusty star-forming galaxies (DSFGs) selected with the South Pole Telescope (SPT). The sources were selected to have S_1.4mm>20 mJy and a dust-like spectrum and, to remove low-z sources, not have bright radio (S_843MHz=3.5. This finding is in contrast to the redshift distribution of radio-identified DSFGs, which have a significantly lower mean redshift of =2.3 and for which only 10-15% of the population is expected to be at z>3. We discuss the effect of gravitational lensing on the redshift distribution and compare our measured redshift distribution to that of models in the literature.

  5. Increased plasma citrulline in mice marks diet-induced obesity and may predict the development of the metabolic syndrome.

    Directory of Open Access Journals (Sweden)

    Manuela Sailer

    Full Text Available In humans, plasma amino acid concentrations of branched-chain amino acids (BCAA and aromatic amino acids (AAA increase in states of obesity, insulin resistance and diabetes. We here assessed whether these putative biomarkers can also be identified in two different obesity and diabetic mouse models. C57BL/6 mice with diet-induced obesity (DIO mimic the metabolic impairments of obesity in humans characterized by hyperglycemia, hyperinsulinemia and hepatic triglyceride accumulation. Mice treated with streptozotocin (STZ to induce insulin deficiency were used as a type 1 diabetes model. Plasma amino acid profiling of two high fat (HF feeding trials revealed that citrulline and ornithine concentrations are elevated in obese mice, while systemic arginine bioavailability (ratio of plasma arginine to ornithine + citrulline is reduced. In skeletal muscle, HF feeding induced a reduction of arginine levels while citrulline levels were elevated. However, arginine or citrulline remained unchanged in their key metabolic organs, intestine and kidney. Moreover, the intestinal conversion of labeled arginine to ornithine and citrulline in vitro remained unaffected by HF feeding excluding the intestine as prime site of these alterations. In liver, citrulline is mainly derived from ornithine in the urea cycle and DIO mice displayed reduced hepatic ornithine levels. Since both amino acids share an antiport mechanism for mitochondrial import and export, elevated plasma citrulline may indicate impaired hepatic amino acid handling in DIO mice. In the insulin deficient mice, plasma citrulline and ornithine levels also increased and additionally these animals displayed elevated BCAA and AAA levels like insulin resistant and diabetic patients. Therefore, type 1 diabetic mice but not DIO mice show the "diabetic fingerprint" of plasma amino acid changes observed in humans. Additionally, citrulline may serve as an early indicator of the obesity-dependent metabolic

  6. Increased plasma citrulline in mice marks diet-induced obesity and may predict the development of the metabolic syndrome.

    Science.gov (United States)

    Sailer, Manuela; Dahlhoff, Christoph; Giesbertz, Pieter; Eidens, Mena K; de Wit, Nicole; Rubio-Aliaga, Isabel; Boekschoten, Mark V; Müller, Michael; Daniel, Hannelore

    2013-01-01

    In humans, plasma amino acid concentrations of branched-chain amino acids (BCAA) and aromatic amino acids (AAA) increase in states of obesity, insulin resistance and diabetes. We here assessed whether these putative biomarkers can also be identified in two different obesity and diabetic mouse models. C57BL/6 mice with diet-induced obesity (DIO) mimic the metabolic impairments of obesity in humans characterized by hyperglycemia, hyperinsulinemia and hepatic triglyceride accumulation. Mice treated with streptozotocin (STZ) to induce insulin deficiency were used as a type 1 diabetes model. Plasma amino acid profiling of two high fat (HF) feeding trials revealed that citrulline and ornithine concentrations are elevated in obese mice, while systemic arginine bioavailability (ratio of plasma arginine to ornithine + citrulline) is reduced. In skeletal muscle, HF feeding induced a reduction of arginine levels while citrulline levels were elevated. However, arginine or citrulline remained unchanged in their key metabolic organs, intestine and kidney. Moreover, the intestinal conversion of labeled arginine to ornithine and citrulline in vitro remained unaffected by HF feeding excluding the intestine as prime site of these alterations. In liver, citrulline is mainly derived from ornithine in the urea cycle and DIO mice displayed reduced hepatic ornithine levels. Since both amino acids share an antiport mechanism for mitochondrial import and export, elevated plasma citrulline may indicate impaired hepatic amino acid handling in DIO mice. In the insulin deficient mice, plasma citrulline and ornithine levels also increased and additionally these animals displayed elevated BCAA and AAA levels like insulin resistant and diabetic patients. Therefore, type 1 diabetic mice but not DIO mice show the "diabetic fingerprint" of plasma amino acid changes observed in humans. Additionally, citrulline may serve as an early indicator of the obesity-dependent metabolic impairments.

  7. The K20 survey. IV. The redshift distribution of Ks<20 galaxies a test of galaxy formation models

    CERN Document Server

    Cimatti, A; Mignoli, M; Daddi, E; Menci, N; Poli, F; Fontana, A; Renzini, A; Zamorani, G; Broadhurst, T J; Cristiani, S; D'Odorico, S; Giallongo, E; Gilmozzi, R

    2002-01-01

    We present the redshift distribution of a complete sample of 480 galaxies with Ks1 and z>1.5 respectively. A ``blind'' comparison is made with the predictions of a set of the most recent LambdaCDM hierarchical merging and pure luminosity evolution (PLE) models. The hierarchical merging models overpredict and underpredict the number of galaxies at low-z and high-z respectively, whereas the PLE models match the median redshift and the low-z distribution, still being able to follow the high-z tail of N(z). We briefly discuss the implications of this comparison and the possible origins of the observed discrepancies. We make the redshift distribution publicly available.

  8. Probing cosmology and gravity with redshift-space distortions around voids

    CERN Document Server

    Hamaus, Nico; Lavaux, Guilhem; Wandelt, Benjamin D

    2015-01-01

    Cosmic voids in the large-scale structure of the Universe affect the peculiar motions of objects in their vicinity. Although these motions are difficult to observe directly, the clustering pattern of their surrounding tracers in redshift space is influenced in a unique way. This allows to investigate the interplay between densities and velocities around voids, which is solely dictated by the laws of gravity. With the help of N-body simulations and derived mock-galaxy catalogs we calculate the average density fluctuations inside and outside voids identified with a watershed algorithm in redshift space and compare the results with the expectation from general relativity and the LCDM model of cosmology. We find that simple linear-theory predictions work remarkably well in describing the dynamics of voids even on relatively small scales. Adopting a Bayesian inference framework, we determine the full posterior probability distribution of our model parameters and forecast the achievable accuracy on measurements of ...

  9. HI Fluctuations at Large Redshifts: III – Simulating the Signal Expected at GMRT

    Indian Academy of Sciences (India)

    Somnath Bharadwaj; Pennathur Sridharan Srikant

    2004-03-01

    We simulate the distribution of neutral hydrogen (HI) at the redshifts = 1.3 and 3.4 using a cosmological N-body simulation along with a prescription for assigning HI masses to the particles. The HI is distributed in clouds whose properties are consistent with those of the damped Lyman- absorption systems (DLAs) seen in quasar spectra. The clustering properties of these clouds are identical to those of the dark matter. We use this to simulate the redshifted HI emission expected at 610 MHz and 325 MHz, two of the observing bands at the GMRT. These are used to predict the correlations expected between the complex visibilities measured at different baselines and frequencies in radio-interferometric observations with the GMRT. The visibility correlations directly probe the power spectrum of HI fluctuations at the epoch when the HI emission originated, and this holds the possibility of using HI observations to study large-scale structures at high .

  10. Modeling the large-scale redshift-space 3-point correlation function of galaxies

    CERN Document Server

    Slepian, Zachary

    2016-01-01

    We present a configuration-space model of the large-scale galaxy 3-point correlation function (3PCF) based on leading-order perturbation theory and including redshift space distortions (RSD). This model should be useful in extracting distance-scale information from the 3PCF via the Baryon Acoustic Oscillation (BAO) method. We include the first redshift-space treatment of biasing by the baryon-dark matter relative velocity. Overall, on large scales the effect of RSD is primarily a renormalization of the 3PCF that is roughly independent of both physical scale and triangle opening angle; for our adopted $\\Omega_{\\rm m}$ and bias values, the rescaling is a factor of $\\sim 1.8$. We also present an efficient scheme for computing 3PCF predictions from our model, important for allowing fast exploration of the space of cosmological parameters in future analyses.

  11. Galactic synchrotron emission and the FIR-radio correlation at high redshift

    CERN Document Server

    Schober, Jennifer; Klessen, Ralf S

    2016-01-01

    Galactic magnetic fields in the local Universe are strong and omnipresent. Now evidence accumulates that galaxies were magnetized already in the early Universe. Theoretical scenarios including the turbulent small-scale dynamo predict magnetic energy densities comparable to the one of turbulence. Based on the assumption of this energy equipartition, we determine the galactic synchrotron flux as a function of redshift. The conditions in the early Universe are different from the present day, in particular the galaxies have more intense star formation. To cover a large range of conditions we consider models based on two different types of galaxies: one model galaxy comparable to the Milky Way and one typical high-z starburst galaxy. We include a model of the steady state cosmic ray spectrum and find that synchrotron emission can be detected up to cosmological redshifts with current and future radio telescopes. Turbulent dynamo theory is in agreement with the origin of the observed correlation between the far-infr...

  12. Deriving Photometric Redshifts using Fuzzy Archetypes and Self-Organizing Maps. I. Methodology

    CERN Document Server

    Speagle, Joshua S

    2015-01-01

    We propose a method to substantially increase the flexibility and power of template fitting-based photometric redshifts by transforming a large numbers of galaxy spectral templates into a corrresponding collection of "fuzzy archetypes" using a suitable set of perturbative priors designed to account for empirical variation in dust attenuation and emission line strengths. To bypass widely seperated degeneracies in parameter space (e.g., the redshift-reddening degeneracy), we train Self-Organizing Maps (SOMs) on a large "model catalogs" generated from appropriate Monte Carlo sampling of our fuzzy archetypes to cluster the predicted observables in a topologically smooth fashion. Subsequent sampling over the SOM then allows full reconstruction of the relevant probability distribution functions (PDFs) using the associated set of inverse mappings from the SOM to the underlying model parameters. This combined approach enables the multi-modal exploration of known variation among galaxy spectral energy distributions (S...

  13. Constraining High Redshift X-ray Sources with Next Generation 21 cm Power Spectrum Measurements

    CERN Document Server

    Ewall-Wice, Aaron; Mesinger, Andrei; Dillon, Joshua S; Liu, Adrian; Pober, Jonathan

    2015-01-01

    We use the Fisher matrix formalism and semi-numerical simulations to derive quantitative predictions of the constraints that power spectrum measurements on next-generation interferometers, such as the Hydrogen Epoch of Reionization Array (HERA) and the Square Kilometre Array (SKA), will place on the characteristics of the X-ray sources that heated the high redshift intergalactic medium. Incorporating observations between $z=5$ and $z=25$, we find that the proposed 331 element HERA and SKA phase 1 will be capable of placing $\\lesssim 10\\%$ constraints on the spectral properties of these first X-ray sources, even if one is unable to perform measurements within the foreground contaminated "wedge" or the FM band. When accounting for the enhancement in power spectrum amplitude from spin temperature fluctuations, we find that the observable signatures of reionization extend well beyond the peak in the power spectrum usually associated with it. We also find that lower redshift degeneracies between the signatures of ...

  14. Fundamental Mechanisms, Predictive Modeling, and Novel Aerospace Applications of Plasma Assisted Combustion. Overview of OSU Research Plan

    Science.gov (United States)

    2009-11-04

    need to keep the l if d i ti b tp asma un orm ur ng en re urs • We know that preheating will improve plasma uniformity • Sustaining plasma in a...0C sc arge p asmas n 2-a r an CxHy air mixtures, at P ~ 0.1 - 1 atm, T=300-800 K 500 600 700 800 P=40 torr, ν=40 kHz Air Air, model Outcome: kinetic...coup ng e ween p asma kinetics and flame chemistry is most important Laboratory for Advanced Fluid Dynamics and Combustion Research 0.0 0.3 0.6 0.9

  15. ALMA REDSHIFTS OF MILLIMETER-SELECTED GALAXIES FROM THE SPT SURVEY: THE REDSHIFT DISTRIBUTION OF DUSTY STAR-FORMING GALAXIES

    Energy Technology Data Exchange (ETDEWEB)

    Weiss, A. [Max-Planck-Institut fuer Radioastronomie, Auf dem Huegel 69, D-53121 Bonn (Germany); De Breuck, C.; Aravena, M.; Biggs, A. D. [European Southern Observatory, Karl-Schwarzschild Strasse, D-85748 Garching bei Muenchen (Germany); Marrone, D. P.; Bothwell, M. [Steward Observatory, University of Arizona, 933 North Cherry Avenue, Tucson, AZ 85721 (United States); Vieira, J. D.; Bock, J. J. [California Institute of Technology, 1200 E. California Blvd., Pasadena, CA 91125 (United States); Aguirre, J. E. [University of Pennsylvania, 209 South 33rd Street, Philadelphia, PA 19104 (United States); Aird, K. A. [University of Chicago, 5640 South Ellis Avenue, Chicago, IL 60637 (United States); Ashby, M. L. N.; Bayliss, M. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Benson, B. A.; Bleem, L. E.; Carlstrom, J. E.; Chang, C. L. [Kavli Institute for Cosmological Physics, University of Chicago, 5640 South Ellis Avenue, Chicago, IL 60637 (United States); Bethermin, M. [Laboratoire AIM-Paris-Saclay, CEA/DSM/Irfu - CNRS - Universite Paris Diderot, CEA-Saclay, Orme des Merisiers, F-91191 Gif-sur-Yvette (France); Bradford, C. M. [Jet Propulsion Laboratory, 4800 Oak Grove Drive, Pasadena, CA 91109 (United States); Brodwin, M. [Department of Physics and Astronomy, University of Missouri, 5110 Rockhill Road, Kansas City, MO 64110 (United States); Chapman, S. C. [Department of Physics and Atmospheric Science, Dalhousie University, Halifax, NS B3H 3J5 Canada (Canada); and others

    2013-04-10

    Using the Atacama Large Millimeter/submillimeter Array, we have conducted a blind redshift survey in the 3 mm atmospheric transmission window for 26 strongly lensed dusty star-forming galaxies (DSFGs) selected with the South Pole Telescope. The sources were selected to have S{sub 1.4{sub mm}} > 20 mJy and a dust-like spectrum and, to remove low-z sources, not have bright radio (S{sub 843{sub MHz}} < 6 mJy) or far-infrared counterparts (S{sub 100{sub {mu}m}} < 1 Jy, S{sub 60{sub {mu}m}} < 200 mJy). We robustly detect 44 line features in our survey, which we identify as redshifted emission lines of {sup 12}CO, {sup 13}CO, C I, H{sub 2}O, and H{sub 2}O{sup +}. We find one or more spectral features in 23 sources yielding a {approx}90% detection rate for this survey; in 12 of these sources we detect multiple lines, while in 11 sources we detect only a single line. For the sources with only one detected line, we break the redshift degeneracy with additional spectroscopic observations if available, or infer the most likely line identification based on photometric data. This yields secure redshifts for {approx}70% of the sample. The three sources with no lines detected are tentatively placed in the redshift desert between 1.7 < z < 2.0. The resulting mean redshift of our sample is z-bar = 3.5. This finding is in contrast to the redshift distribution of radio-identified DSFGs, which have a significantly lower mean redshift of z-bar = 2.3 and for which only 10%-15% of the population is expected to be at z > 3. We discuss the effect of gravitational lensing on the redshift distribution and compare our measured redshift distribution to that of models in the literature.

  16. Galaxy Mergers and Dark Matter Halo Mergers in LCDM: Mass, Redshift, and Mass-Ratio Dependence

    Energy Technology Data Exchange (ETDEWEB)

    Stewart, Kyle R.; Bullock, James S.; Barton, Elizabeth J.; /UC, Irvine; Wechsler, Risa H.; /KIPAC, Menlo Park /SLAC

    2009-08-03

    We employ a high-resolution LCDM N-body simulation to present merger rate predictions for dark matter halos and investigate how common merger-related observables for galaxies - such as close pair counts, starburst counts, and the morphologically disturbed fraction - likely scale with luminosity, stellar mass, merger mass ratio, and redshift from z = 0 to z = 4. We provide a simple 'universal' fitting formula that describes our derived merger rates for dark matter halos a function of dark halo mass, merger mass ratio, and redshift, and go on to predict galaxy merger rates using number density-matching to associate halos with galaxies. For example, we find that the instantaneous merger rate of m/M > 0.3 mass ratio events into typical L {approx}> fL{sub *} galaxies follows the simple relation dN/dt {approx_equal} 0.03(1+f)Gyr{sup -1} (1+z){sup 2.1}. Despite the rapid increase in merger rate with redshift, only a small fraction of > 0.4L{sub *} high-redshift galaxies ({approx} 3% at z = 2) should have experienced a major merger (m/M > 0.3) in the very recent past (t < 100 Myr). This suggests that short-lived, merger-induced bursts of star formation should not contribute significantly to the global star formation rate at early times, in agreement with observational indications. In contrast, a fairly high fraction ({approx} 20%) of those z = 2 galaxies should have experienced a morphologically transformative merger within a virial dynamical time. We compare our results to observational merger rate estimates from both morphological indicators and pair-fraction based determinations between z = 0-2 and show that they are consistent with our predictions. However, we emphasize that great care must be made in these comparisons because the predicted observables depend very sensitively on galaxy luminosity, redshift, overall mass ratio, and uncertain relaxation timescales for merger remnants. We show that the majority of bright galaxies at z = 3 should have undergone a

  17. DES Science Portal: Computing Photometric Redshifts

    Energy Technology Data Exchange (ETDEWEB)

    Gschwend, Julia [LIneA, Rio de Janeiro

    2016-01-01

    An important challenge facing photometric surveys for cosmological purposes, such as the Dark Energy Survey (DES), is the need to produce reliable photometric redshifts (photo-z). The choice of adequate algorithms and configurations and the maintenance of an up-to-date spectroscopic database to build training sets, for example, are challenging tasks when dealing with large amounts of data that are regularly updated and constantly growing. In this paper, we present the first of a series of tools developed by DES, provided as part of the DES Science Portal, an integrated web-based data portal developed to facilitate the scientific analysis of the data, while ensuring the reproducibility of the analysis. We present the DES Science Portal photometric redshift tools, starting from the creation of a spectroscopic sample to training the neural network photo-z codes, to the final estimation of photo-zs for a large photometric catalog. We illustrate this operation by calculating well calibrated photo-zs for a galaxy sample extracted from the DES first year (Y1A1) data. The series of processes mentioned above is run entirely within the Portal environment, which automatically produces validation metrics, and maintains the provenance between the different steps. This system allows us to fine tune the many steps involved in the process of calculating photo-zs, making sure that we do not lose the information on the configurations and inputs of the previous processes. By matching the DES Y1A1 photometry to a spectroscopic sample, we define different training sets that we use to feed the photo-z algorithms already installed at the Portal. Finally, we validate the results under several conditions, including the case of a sample limited to i<22.5 with the color properties close to the full DES Y1A1 photometric data. This way we compare the performance of multiple methods and training configurations. The infrastructure presented here is an effcient way to test several methods of

  18. The Feasibility of Constraining Dark Energy Using LAMOST Redshift Survey

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    We consider using future redshift surveys with the Large Sky Area MultiObject Fiber Spectroscopic Telescope (LAMOST) to constrain the equation of state of dark energy ω. We analyze the Alcock & Paczynski (AP) effect imprinted on the two-point correlation function of galaxies in redshift space. The Fisher matrix analysis is applied to estimate the expected error bounds of ω0 and ωa from galaxy redshift surveys, ω0 and ωa being the two parameters in the equation of state parametrization ω(z) = ω0 + ωaz/(1 -+ z). Strong degeneracies between ω0 and ωa are found. The direction of the degeneracy in ω0 - ωa plane, however, rotates counter-clockwise as the redshift increases. LAMOST can potentially contribute in the redshift range up to 0.5. In combination with other high redshift surveys, such as the proposed KiloAperture Optical Spectrograph project (KAOS), the joint constraint derived from galaxy surveys at different redshift ranges is likely to efficiently break the degeneracy of ω0 and ωa. We do not anticipate that the nature of dark energy can be well constrained with LAMOST alone, but it may help to reduce the error bounds expected from other observations, such as the Supernova/Acceleration Probe (SNAP).

  19. Calibrating galaxy redshifts using absorption by the surrounding intergalactic medium

    Science.gov (United States)

    Rakic, Olivera; Schaye, Joop; Steidel, Charles C.; Rudie, Gwen C.

    2011-07-01

    Rest-frame UV spectral lines of star-forming galaxies are systematically offset from the galaxies' systemic redshifts, probably because of large-scale outflows. We calibrate galaxy redshifts measured from rest-frame UV lines by utilizing the fact that the mean H I Lyα absorption profiles around the galaxies, as seen in spectra of background objects, must be symmetric with respect to the true galaxy redshifts if the galaxies are oriented randomly with respect to the lines of sight to the background objects. We use 15 bright QSOs at z≈ 2.5-3 and more than 600 foreground galaxies with spectroscopic redshifts at z≈ 1.9-2.5. All galaxies are within 2 Mpc proper from the lines of sight to the background QSOs. We find that Lyα emission and ISM absorption redshifts require systematic shifts of ? and ?, respectively. Assuming a Gaussian distribution, we put 1σ upper limits on possible random redshift offsets of ? for Lyα and ? for ISM redshifts. For the small subset (Technology, the University of California and NASA, and was made possible by the generous financial support of the W.M. Keck Foundation.

  20. High-redshift major mergers weakly enhance star formation

    Science.gov (United States)

    Fensch, J.; Renaud, F.; Bournaud, F.; Duc, P.-A.; Agertz, O.; Amram, P.; Combes, F.; Di Matteo, P.; Elmegreen, B.; Emsellem, E.; Jog, C. J.; Perret, V.; Struck, C.; Teyssier, R.

    2017-02-01

    Galaxy mergers are believed to trigger strong starbursts. This is well assessed by observations in the local Universe. However, the efficiency of this mechanism has poorly been tested so far for high-redshift, actively star-forming, galaxies. We present a suite of pc-resolution hydrodynamical numerical simulations to compare the star formation process along a merging sequence of high- and low-redshift galaxies, by varying the gas mass fraction between the two models. We show that, for the same orbit, high-redshift gas-rich mergers are less efficient than low-redshift ones at producing starbursts; the star formation rate excess induced by the merger and its duration are both around 10 times lower than in the low gas fraction case. The mechanisms that account for the star formation triggering at low redshift - the increased compressive turbulence, gas fragmentation, and central gas inflows - are only mildly, if not at all, enhanced for high gas fraction galaxy encounters. Furthermore, we show that the strong stellar feedback from the initially high star formation rate in high-redshift galaxies does not prevent an increase of the star formation during the merger. Our results are consistent with the observed increase of the number of major mergers with increasing redshift being faster than the respective increase in the number of starburst galaxies.

  1. Plasma IL-6/IL-10 Ratio and IL-8, LDH, and HBDH Level Predict the Severity and the Risk of Death in AIDS Patients with Pneumocystis Pneumonia.

    Science.gov (United States)

    Sun, Jia; Su, Junwei; Xie, Yirui; Yin, Michael T; Huang, Ying; Xu, Lijun; Zhou, Qihui; Zhu, Biao

    2016-01-01

    Objective. To identify blood biomarkers to predict severity and mortality in AIDS PCP patients. Methods. Biomarkers including clinical parameters and plasma inflammatory cytokines were assessed in 32 HIV-infected patients with Pneumocystis pneumonia (PCP) at time of admission. Predictive value of the biomarkers for clinical severity and in-hospital mortality was evaluated by corresponding ROC curve. Results. Levels of CRP, WBC, LDH, HBDH, and Ferritin were significantly higher in the severe and nonsurvivor AIDS PCP patients. These important biochemical indicators have inverse correlation with oxygenation index, especially levels of LDH (P = 0.008, R (2) = 0.258), HBDH (P = 0.001, R (2) = 0.335), and Ferritin (P = 0.005, R (2) = 0.237). Plasma IL-8 and IL-6 levels were significantly higher in patients with PaO2/FiO2 ≤ 200 mmHg and nonsurvivors than in those with PaO2/FiO2 > 200 mmHg and survivors. Severe and nonsurvival groups showed higher ratio of mean IL-6/IL-10 level (1.78 ± 1.56, P < 0.001; 1.11 ± 0.72, P = 0.043), larger AUC (95% CI 0.781-1.000, P < 0.001; 95% CI 0.592-0.917, P = 0.043), and more significantly inverse correlation with the oxygenation index. Conclusion. Plasma IL-8, LDH, and HBDH levels and IL-6/IL-10 ratio could be helpful for early evaluation of the severity and predicting fatal outcomes in AIDS PCP patients.

  2. Plasma IL-6/IL-10 Ratio and IL-8, LDH, and HBDH Level Predict the Severity and the Risk of Death in AIDS Patients with Pneumocystis Pneumonia

    Directory of Open Access Journals (Sweden)

    Jia Sun

    2016-01-01

    Full Text Available Objective. To identify blood biomarkers to predict severity and mortality in AIDS PCP patients. Methods. Biomarkers including clinical parameters and plasma inflammatory cytokines were assessed in 32 HIV-infected patients with Pneumocystis pneumonia (PCP at time of admission. Predictive value of the biomarkers for clinical severity and in-hospital mortality was evaluated by corresponding ROC curve. Results. Levels of CRP, WBC, LDH, HBDH, and Ferritin were significantly higher in the severe and nonsurvivor AIDS PCP patients. These important biochemical indicators have inverse correlation with oxygenation index, especially levels of LDH (P=0.008, R2=0.258, HBDH (P=0.001, R2=0.335, and Ferritin (P=0.005, R2=0.237. Plasma IL-8 and IL-6 levels were significantly higher in patients with PaO2/FiO2 ≤ 200 mmHg and nonsurvivors than in those with PaO2/FiO2 > 200 mmHg and survivors. Severe and nonsurvival groups showed higher ratio of mean IL-6/IL-10 level (1.78 ± 1.56, P<0.001; 1.11 ± 0.72, P=0.043, larger AUC (95% CI 0.781–1.000, P<0.001; 95% CI 0.592–0.917, P=0.043, and more significantly inverse correlation with the oxygenation index. Conclusion. Plasma IL-8, LDH, and HBDH levels and IL-6/IL-10 ratio could be helpful for early evaluation of the severity and predicting fatal outcomes in AIDS PCP patients.

  3. Cellular Levels of HIV Unspliced RNA from Patients on Combination Antiretroviral Therapy with Undetectable Plasma Viremia Predict the Therapy Outcome

    NARCIS (Netherlands)

    Pasternak, A.O.; Jurriaans, S.; Bakker, M.; Prins, J.M.; Berkhout, B.; Lukashov, V.V.

    2009-01-01

    Background: Combination antiretroviral therapy (cART), the standard of care for HIV-1 infection, is considered to be successful when plasma viremia remains below the detection limit of commercial assays. Yet, cART fails in a substantial proportion of patients after the apparent success. No laborator

  4. Plasma proteomics classifiers improve risk prediction for renal disease in patients with hypertension or type 2 diabetes

    NARCIS (Netherlands)

    Pena, Michelle J.; Jankowski, Joachim; Heinze, Georg; Kohl, Maria; Heinzel, Andreas; Bakker, Stephan J. L.; Gansevoort, Ron T.; Rossing, Peter; de Zeeuw, Dick; Heerspink, Hiddo J. Lambers; Jankowski, Vera

    2015-01-01

    OBJECTIVE: Micro and macroalbuminuria are strong risk factors for progression of nephropathy in patients with hypertension or type 2 diabetes. Early detection of progression to micro and macroalbuminuria may facilitate prevention and treatment of renal diseases. We aimed to develop plasma proteomics

  5. Plasma levels of HDL subpopulations and remnant lipoproteins predict the extent of angiographically defined disease in post-menopausal women

    Science.gov (United States)

    The association of coronary heart disease (CHD) with subpopulations of triglyceride (TG)-rich lipoproteins and high-density lipoproteins (HDL) is established in men, but has not been well characterized in women. Plasma HDL subpopulation concentrations, quantified by 2-dimensional gel electrophoresis...

  6. Plasma proteomics classifiers improve risk prediction for renal disease in patients with hypertension or type 2 diabetes

    NARCIS (Netherlands)

    Pena, Michelle J.; Jankowski, Joachim; Heinze, Georg; Kohl, Maria; Heinzel, Andreas; Bakker, Stephan J. L.; Gansevoort, Ron T.; Rossing, Peter; de Zeeuw, Dick; Heerspink, Hiddo J. Lambers; Jankowski, Vera

    2015-01-01

    OBJECTIVE: Micro and macroalbuminuria are strong risk factors for progression of nephropathy in patients with hypertension or type 2 diabetes. Early detection of progression to micro and macroalbuminuria may facilitate prevention and treatment of renal diseases. We aimed to develop plasma proteomics

  7. Persistent high levels of plasma oxidized low-density lipoprotein after acute myocardial infarction predict stent restenosis

    NARCIS (Netherlands)

    T. Naruko; M. Ueda; S. Ehara; A. Itoh; K. Haze; N. Shirai; Y. Ikura; M. Ohsawa; H. Itabe; Y. Kobayashi; H. Yamagishi; M. Yoshiyama; J. Yoshikawa; A.E. Becker

    2006-01-01

    Objective-Recently, elevated levels of plasma oxidized low-density lipoprotein (LDL) have been shown to relate to plaque instability in human atherosclerotic lesions. We investigated prospectively patients admitted with acute myocardial infarction (AMI) who underwent primary coronary stenting to eva

  8. β-FIBRINOGEN PROMOTER-455 G/A (HaeⅢ) POLYMORPHISM PREDICTION OF PLASMA FIBRINOGEN BUT NOT OF ISCHEMIC CEREBROVASCULAR DISEASE

    Institute of Scientific and Technical Information of China (English)

    毕胜; 王德生; 李国忠; 温世荣; 潘尚哈

    2004-01-01

    Objective The-455 G/A (HaeⅢ) polymorphism of β-fibrinogen gene influences levels of plasma fibrinogen. We further investigated whether it influences the risk of ischemic cerebrovascular disease. Methods We accumulated 134 acute ischemic cerebrovascular disease (ICVD) cases and compared their -455 G/A status with a control group (n = 166). The β-fibrinogen gene -455 G/A polymorphism was analyzed for all subjects by PCR-RFLP with the restrictive enzyme HaeⅢ. Results Plasma fibrinogen was higher in AA homozygous participants (341 mg/dL) than in participants carrying the G allele: GA (290 mg/dL), GG (298 mg/dL) in the control group. Plasma fibrinogen was also higher in AA homozygous patients (353 mg/dL) than in cases carrying the G allele: GA (287mg/dL), GG (302 mg/dL) in the ICVD group. However, there was no significant association between β-fibrinogen gene -455 G/A polymorphism and ICVD group. Conclusions Although a small effect cannot be excluded, β-fibrinogen gene -455 G/A polymorphism is an independent predictor of plasma fibrinogen, but not of ischemic cerebrovascular disease.

  9. A new method of modelling early plasma creatinine changes predicts 1-year graft function after kidney transplantation

    DEFF Research Database (Denmark)

    Krogstrup, Nicoline V; Bibby, Bo Martin; Aulbjerg, Camilla;

    2016-01-01

    BACKGROUND: Delayed graft function after renal transplantation is associated with inferior long-term outcome. To evaluate the impact of slow onset graft function, we aimed to model and correlate early changes in plasma creatinine (p-cr) with long-term graft function. MATERIALS: In a single centre...

  10. Predictive value of plasma copeptin level for the risk and mortality of heart failure: a meta-analysis.

    Science.gov (United States)

    Yan, Jian-Jun; Lu, Ying; Kuai, Zheng-Ping; Yong, Yong-Hong

    2017-02-28

    Epidemiologic studies are inconsistent regarding the association between plasma copeptin level and heart failure (HF). The aim of this study was to perform a meta-analysis to determine whether high level of copeptin is correlated with incidence of HF and mortality in patients with HF. We searched PUBMED and EMBASE databases for studies conducted from 1966 through May 2016 to identify studies reporting hazard ratio (HR) estimates with 95% confidence intervals (CIs) for the association between plasma copeptin level and HF. A random-effects model was used to combine study-specific risk estimates. A total of 13 studies were included in the meta-analysis, with five studies on the incidence of HF and eight studies on the mortality of patients with HF. For incidence of HF, the summary HR indicated a borderline positive association of high plasma copeptin level with HF risk (HR, 1.60; 95% CI, 0.90-2.85). Furthermore, an increase of 1 standard deviation in log copeptin level was associated with a 17% increase in the risk of incident HF (HR, 1.17; 95% CI, 1.02-1.33). For all-cause mortality of patients with HF, we also found a significant association between elevated plasma copeptin level and increased mortality of HF (HR, 1.76; 95% CI, 1.33-2.33). Our dose-response analysis indicated that an increment in copeptin level of 1 pmol/l was associated with a 3% increase in all-cause mortality (HR, 1.03; 95% CI, 1.01-1.05). In conclusion, our results suggest that elevated plasma copeptin level is associated with an increased risk of HF and all-cause mortality in patients with HF.

  11. VizieR Online Data Catalog: Galaxy Redshifts (Rood 1980)

    Science.gov (United States)

    Rood, H. J.

    1995-10-01

    The Catalog of Galaxy Redshifts was compiled by Dr. Rood to enter the most accurate redshift for each entry in the Uppsala General Catalog of Galaxies below 15000 km/s, plus some fainter galaxies in the fields of rich clusters, plus some southern galaxies. The catalog is 99 percent complete for declinations north of -2.5deg and blue magnitude (Pmag) brighter than 13. The present documentation is mostly adapted from the "Documentation of the Machine-Readable Version of the Catalog of Galaxy Redshifts" by Theresa A. Nagy and Robert S. Hill, May 1981, prepared for NASA GSFC, Greenbelt, No SSD-T-5069-0013-81. (1 data file).

  12. Are GRBs the same at high and low redshift?

    CERN Document Server

    Littlejohns, O M; Willingale, R; O'Brien, P T; Evans, P A; Levan, A J

    2013-01-01

    Due to their highly luminous nature, gamma-ray bursts (GRBs) are useful tools in studying the early Universe (up to z = 10). We consider whether the available subset of Swift high redshift GRBs are unusual when compared to analogous simulations of a bright low redshift sample. By simulating data from the Burst Alert Telescope (BAT; Barthelmy et al. 2005) the light curves of these bright bursts are obtained over an extensive range of redshifts, revealing complicated evolution in properties of the prompt emission such as T90.

  13. VERDI: A Web Database System for Redshift Surveys

    Science.gov (United States)

    Wirth, G. D.; Patton, D. R.

    The Victoria Explorer for Redshift Databases on the Internet (VERDI) is a Web-based data retrieval system which allows users to access tabular data, images, and spectra of astronomical objects and to perform queries on the underlying database. We developed VERDI for use with the CNOC2 Field Galaxy Redshift Survey, but designed it to be generally applicable to deep galaxy redshift surveys. The software is freely available at http://astrowww.phys.uvic.ca/~cnoc, can easily be reconfigured and customized by the user, and performs well enough to support databases of many thousands of objects.

  14. Gravitational redshift from rotating body having intense magnetic field

    CERN Document Server

    Dubey, Anuj Kumar

    2016-01-01

    It is well known fact that gravitational field can alter the space-time structure and gravitational redshift is its one example. Electromagnetic field can also alter the space-time similar to gravitational field. So electromagnetic field can give rise to an additional effect on gravitational redshift. There are many objects in nature, like neutron stars, magnetars etc which have high amount of rotation and magnetic field. In the present paper we will derive the expression of gravitational redshift from rotating body having intense magnetic field by using the action function of the electromagnetic fields.

  15. Extracting Information from the Gravitational Redshift of Compact Rotating Objects

    Indian Academy of Sciences (India)

    Paul D. Nuñez; Marek Nowakowski

    2010-06-01

    Essential macroscopic internal properties of compact objects can be related to each other with the help of General Relativity. A somewhat familiar example is the relationship between the compactness / and the gravitational redshift for nonrotating bodies. Rotation poses new challenges when trying to relate observed or potentially observed quantities such as the graviational redshift, mass, radius, and angular velocity. Using a perturbative approach, we present an analytical approximation whose purpose is to relate these quantities. Two main results are highlighted: Derivation of a new maximal angular velocity depending only on the mass of the object and a possible estimate of the radius from a measurement of the gravitational redshift.

  16. Exhausting the Information: Novel Bayesian Combination of Photometric Redshift PDFs

    CERN Document Server

    Kind, M Carrasco

    2014-01-01

    The estimation and utilization of photometric redshift (photo-z) PDFs has become increasingly important over the last few years. Primarily this is because of the prominent role photo-z PDFs play in enabling photometric survey data to be used to make cosmological constraints, especially when compared to single estimates. Currently there exist a wide variety of algorithms to compute photo-z's, each with their own strengths and weaknesses. In this paper, we present a novel and efficient Bayesian framework that combines the results from different photo-z techniques into a more powerful and robust estimate by maximizing the information from the photometric data. To demonstrate this we use a supervised machine learning technique based on prediction trees and a random forest, an unsupervised method based on self organizing maps and a random atlas, and a standard template fitting method but can be easily extend to other existing techniques. We use data from the DEEP2 survey and more than $10^6$ galaxies from the SDSS...

  17. Redshifted 21-cm Signals in the Dark Ages

    CERN Document Server

    Kim, Juhan

    2009-01-01

    We have carried out semianalytic simulations to build redshifted 21-cm maps in the dark ages. An entropy-floor model is adopted for planting protogalaxies in simulated minihaloes. The model allocates gas quantities such as baryonic mass and temperature to every $N$-body particle and extensively exploits the particle nature of the data in the subsequent analysis. We have found that the number density of simulated minihaloes in the early universe is well described by the Sheth & Tormen function and consequently the signal powers of simulated minihaloes are far greater than the Press & Schechter prediction presented by Furlanetto (2006b). Even though the matter power spectrum measured in the halo particles at $z=15$ is about an order of magnitude smaller than the intergalactic medium (IGM), the 21-cm signal fluctuations of haloes are, to the contrary, one order of magnitude higher than the embedding adiabatic IGM on scales, $k\\lesssim 10 h{\\rm Mpc}^{-1}$. But their spectral shapes are almost same to each...

  18. Broadband Observations of High Redshift Blazars

    CERN Document Server

    Paliya, Vaidehi S; Fabian, A C; Stalin, C S

    2016-01-01

    We present a multi-wavelength study of four high redshift blazars, S5 0014+81 ($z=3.37$), CGRaBS J0225+1846 ($z=2.69$), BZQ J1430+4205 ($z=4.72$), and 3FGL J1656.2$-$3303 ($z=2.40$), using the quasi-simultaneous data from {\\it Swift}, {\\it NuSTAR}, and {\\it Fermi}-Large Area Telescope (LAT) and also the archival {\\it XMM-Newton} observations. Other than 3FGL J1656.2$-$3303, none of the sources were known as $\\gamma$-ray emitters and our analysis of $\\sim$7.5 years of LAT data reveals the first time detection of the statistically significant $\\gamma$-ray emission from CGRaBS J0225+1846. We generate the broadband spectral energy distributions (SED) of all the objects, centering at the epoch of {\\it NuSTAR} observations and reproduce them using a one zone leptonic emission model. The optical$-$UV emission in all the objects can be explained by the radiation from the accretion disk, whereas, X-ray to $\\gamma$-ray window of the SEDs are found to be dominated by the inverse Compton scattering off the broad line reg...

  19. The IMF from Low to High Redshift

    CERN Document Server

    Greggio, Laura

    2012-01-01

    From time to time, and quite more frequently in recent years, claims appear favoring a variable Initial Mass Function (IMF), one way or another, either in time or space. In this chapter we add our two pennies of wisdom, illustrating how the IMF affects various properties of galaxies and galaxy clusters. We start by showing that even relatively small variations of the IMF slope have large effects on the demography of stellar populations, moving the bulk of the stellar mass from one end to the other of the distribution. We then point out how the slope of the IMF in different mass ranges controls specific major properties of galaxies and clusters. The slope of the IMF below ~1 solar mass controls the M/L ratio of local ellipticals, whereas the slope between ~1 and ~1.4 solar masses controls the evolution with redshift of such ratio, hence of the fundamental plane of elliptical galaxies. Similarly, the slope between ~1 and ~40 solar masses drives the ratio of the global metal mass in clusters of galaxies to their...

  20. Compact Quiescent Galaxies at Intermediate Redshifts

    CERN Document Server

    Hsu, Li-Yen; Shih, Hsin-Yi

    2014-01-01

    From several searches of the area common to the Sloan Digital Sky Survey and the United Kingdom Infrared Telescope Infrared Deep Sky Survey, we have identified objects that have properties similar to those of the luminous quiescent compact galaxies found at z > 2. Here we present our results of 22 galaxies between z ~ 0.4 and z ~ 0.9 based on observations with the Keck I, Keck II and Subaru telescopes on Mauna Kea. By exploring sizes, morphologies, and stellar populations of these galaxies, we found that most of the galaxies we identified actually formed most of their stars at z 2 in the literature. Several of these young objects appear to be disk-like or possibly prolate. This lines up with several previous studies, which found that massive quiescent galaxies at high redshifts often have disk-like morphologies. If these galaxies were to be confirmed to be disks, their formation would be more likely caused by gas accretion than by major mergers. On the other hand, if these galaxies were to be confirmed to be...

  1. Predicted changes in fatty acid intakes, plasma lipids, and cardiovascular disease risk following replacement of trans fatty acid-containing soybean oil with application-appropriate alternatives.

    Science.gov (United States)

    Lefevre, Michael; Mensink, Ronald P; Kris-Etherton, Penny M; Petersen, Barbara; Smith, Kim; Flickinger, Brent D

    2012-10-01

    The varied functional requirements satisfied by trans fatty acid (TFA)--containing oils constrains the selection of alternative fats and oils for use as potential replacements in specific food applications. We aimed to model the effects of replacing TFA-containing partially hydrogenated soybean oil (PHSBO) with application-appropriate alternatives on population fatty acid intakes, plasma lipids, and cardiovascular disease (CVD) risk. Using the National Health and Nutrition Examination Survey 24-hour dietary recalls for 1999-2002, we selected 25 food categories, accounting for 86 % of soybean oil (SBO) and 79 % of TFA intake for replacement modeling. Before modeling, those in the middle quintile had a mean PHSBO TFA intake of 1.2 % of energy. PHSBO replacement in applications requiring thermal stability by either low-linolenic acid SBO or mid-oleic, low-linolenic acid SBO decreased TFA intake by 0.3 % of energy and predicted CVD risk by 0.7-0.8 %. PHSBO replacement in applications requiring functional properties with palm-based oils reduced TFA intake by 0.8 % of energy, increased palmitic acid intake by 1.0 % of energy, and reduced predicted CVD risk by 0.4 %, whereas replacement with fully hydrogenated interesterified SBO reduced TFA intake by 0.7 % of energy, increased stearic acid intake by 1.0 % of energy, and decreased predicted CVD risk by 1.2 %. PHSBO replacement in both thermal and functional applications reduced TFA intake by 1.0 % of energy and predicted CVD risk by 1.5 %. Based solely on changes in plasma lipids and lipoproteins, all PHSBO replacement models reduced estimated CVD risk, albeit less than previously reported using simpler replacement models.

  2. Predicting Zonal Flows -- A Comprehensive Reynolds-Stress Response-Functional from First-Principles-Plasma-Turbulence Computations

    CERN Document Server

    Guertler, Niels

    2011-01-01

    Turbulence driven zonal flows play an important role in fusion devices since they improve plasma confinement by limiting the level of anomalous transport. Current theories mostly focus on flow excitation but do not self-consistently describe the nearly stationary zonal flow turbulence equilibrium state. First-principles two-fluid turbulence studies are used to construct a Reynolds stress response functional from observations in turbulent states. This permits, for the first time, a reliable charting of zonal flow turbulence equilibria.

  3. Reduction in plasma cell proliferation after initial therapy in newly diagnosed multiple myeloma measures treatment response and predicts improved survival.

    Science.gov (United States)

    Larsen, Jeremy T; Chee, Cheng E; Lust, John A; Greipp, Philip R; Rajkumar, S Vincent

    2011-09-08

    Standard myeloma treatment response criteria are determined principally by changes in the monoclonal protein. Reduction in the size of the proliferative component of malignant plasma cells may be an additional metric of assessing response to therapy. We retrospectively analyzed 176 patients with newly diagnosed myeloma with a measurable plasma cell labeling index (PCLI) at diagnosis and repeat measurement 4 months after initiation of therapy. PCLI response was defined as a ≥ 60% reduction. Baseline PCLI is an independent prognostic factor; therefore, we categorized patients into 3 groups: PCLI ≥ 3% (high), ≥ 1% (intermediate), and compared with 29 months in nonresponders (P = .02). Improved median overall survival with PCLI response occurred in the high initial PCLI group (28 vs 7 months; P = .003) and intermediate group (64 vs 24 months; P = .002). The application of PCLI response and serum M-spike response together provided further prognostic information. On multivariate analysis, the prognostic value of PCLI response was independent of β(2)-microglobulin, elevated creatinine, serum M-spike response, and baseline PCLI. We conclude that a significant reduction in plasma cell proliferation in patients with newly diagnosed myeloma is an important predictor of survival.

  4. The Doppler Effect: A Consideration of Quasar Redshifts.

    Science.gov (United States)

    Gordon, Kurtiss J.

    1980-01-01

    Provides information on the calculation of the redshift to blueshift ratio introduced by the transverse Doppler effect at relativistic speeds. Indicates that this shift should be mentioned in discussions of whether quasars are "local" rather than "cosmological" objects. (GS)

  5. Using quasars as standard clocks for measuring cosmological redshift.

    Science.gov (United States)

    Dai, De-Chang; Starkman, Glenn D; Stojkovic, Branislav; Stojkovic, Dejan; Weltman, Amanda

    2012-06-08

    We report hitherto unnoticed patterns in quasar light curves. We characterize segments of the quasar's light curves with the slopes of the straight lines fit through them. These slopes appear to be directly related to the quasars' redshifts. Alternatively, using only global shifts in time and flux, we are able to find significant overlaps between the light curves of different pairs of quasars by fitting the ratio of their redshifts. We are then able to reliably determine the redshift of one quasar from another. This implies that one can use quasars as standard clocks, as we explicitly demonstrate by constructing two independent methods of finding the redshift of a quasar from its light curve.

  6. Structure of the Universe at Small and High Redshifts

    Science.gov (United States)

    Doroshkevich, A.; Turchaninov, V.

    1998-12-01

    The approximate theoretical description of the formation and evolution of the structure of the universe proposed by Demianski and Doroshkevich (1998) is compared with observed and simulated matter distribution at small and high redshifts. It is found that for the CDM-like power spectrum and suitable parameters of the cosmological model the effective matter compression reaches at small redshifts the observed scales Rwall ~20 - 25h^{-1}Mpc with the typical mean separation of wall-like elements DSLSS 50 - 70h^{-1}Mpc. We show that the same theoretical model explains well both the redshift, temperature and NHI distributions of absorption lines observed in the spectra of quasars at redshifts 2 <= z <= 3.5. The models with 0.3 <= Omega_m <= 0.5 give better description of the observed structure parameters.

  7. Gravitational Redshift of Emission Lines in the AGN Spectra

    CERN Document Server

    Bon, Nataša; Marziani, Paola; Jovanović, Predrag

    2016-01-01

    The detection of gravitationally redshifted optical emission lines has been reported just for a few active galaxies. In this paper we give a short overview of studies that analyzed or exploited the detection of the gravitational redshift in optical AGN spectra. In addition, we tested the consistency of gravitational redshift as the physical origin of the redward shifts observed in their spectra using a sample of $\\approx$ 50 Hamburg-ESO intermediate to high redshift quasars that are among the most luminous quasars known ($10^{47} \\lesssim L \\lesssim 10^{48}$ erg/s), and are expected to host very massive black holes. To this aim we modeled the line profile with accretion disk models around a black hole.

  8. Photometric Redshift with Bayesian Priors on Physical Properties of Galaxies

    CERN Document Server

    Tanaka, Masayuki

    2015-01-01

    We present a proof-of-concept analysis of photometric redshifts with Bayesian priors on physical properties of galaxies. This concept is particularly suited for upcoming/on-going large imaging surveys, in which only several broad-band filters are available and it is hard to break some of the degeneracies in the multi-color space. We construct model templates of galaxies using a stellar population synthesis code and apply Bayesian priors on physical properties such as stellar mass and star formation rate. These priors are a function of redshift and they effectively evolve the templates with time in an observationally motivated way. We demonstrate that the priors help reduce the degeneracy and deliver significantly improved photometric redshifts. Furthermore, we show that a template error function, which corrects for systematic flux errors in the model templates as a function of rest-frame wavelength, delivers further improvements. One great advantage of our technique is that we simultaneously measure redshifts...

  9. The Doppler Effect: A Consideration of Quasar Redshifts.

    Science.gov (United States)

    Gordon, Kurtiss J.

    1980-01-01

    Provides information on the calculation of the redshift to blueshift ratio introduced by the transverse Doppler effect at relativistic speeds. Indicates that this shift should be mentioned in discussions of whether quasars are "local" rather than "cosmological" objects. (GS)

  10. Direct Determination of Expansion History Using Redshift Distortions

    CERN Document Server

    Song, Yong-Seon

    2012-01-01

    We investigate direct determination of expansion history using redshift distortions without plugging into detailed cosmological parameters. The observed spectra in redshift space include a mixture of information: fluctuations of density-density and velocity-velocity spectra, and distance measures of perpendicular and parallel components to the line of sight. Unfortunately it is hard to measure all the components simultaneously without any specific prior assumption. Common prior assumptions include a linear/quasi-linear model of redshift distortions or a model for the shape of the power spectra, which eventually breaks down on small scales at later epochs where nonlinear structure formation disturbs coherent growth. The degeneracy breaking between the effect of cosmic distances and redshift distortions for example depends on the prior we assume. As an alternative approach is to utilize the cosmological principle inscribed in the heart of the Friedmann-Lema\\^itre-Robertson-Walker (hereafter FLRW) universe, that...

  11. Photometric redshifts for supernovae Ia in the Supernova Legacy Survey

    CERN Document Server

    Palanque-Delabrouille, Nathalie; Pascal, S; Rich, J; Guy, J; Bazin, G; Astier, P; Balland, C; Basa, S; Carlberg, R G; Conley, A; Fouchez, D; Hardin, D; Hook, I M; Howell, D A; Pain, R; Perrett, K; Pritchet, C J; Regnault, N; Sullivan, M

    2009-01-01

    We present a method using the SALT2 light curve fitter to determine the redshift of Type Ia supernovae in the Supernova Legacy Survey (SNLS) based on their photometry in g', r', i' and z'. On 289 supernovae of the first three years of SNLS data, we obtain a precision $\\sigma_{\\Delta z/(1+z)} = 0.022$ on average up to a redshift of 1.0, with a higher precision of 0.016 for z0.45. The rate of events with $|\\Delta z|/(1+z)>0.15$ (catastrophic errors) is 1.4%. Both the precision and the rate of catastrophic errors are better than what can be currently obtained using host galaxy photometric redshifts. Photometric redshifts of this precision may be useful for future experiments which aim to discover up to millions of supernovae Ia but without spectroscopy for most of them.

  12. Increased plasma C-reactive protein level predicts rapid progression of non-target atherosclerotic lesions in patients with stable angina after stenting

    Institute of Scientific and Technical Information of China (English)

    XU Yan-lu; MA Wei-hua; YAO Min; LIU Hai-bo; WU Yong-jian; CHEN Jue; YOU Shi-jie; DAI Jun; XIA Ran; GAO Run-lin; LI Jian-jun; XU Bo; ZHUCheng-gang; YANG Yue-jin; CHEN Ji-lin; QIAO Shu-bing; YUAN Jin-qing; QIN Xue-wen

    2011-01-01

    Background Although the role of C-reactive protein (CRP) in predicting rapid progression of atherosclerotic lesions has been intensively studied in unstable coronary artery disease, the data from patients with stable angina (SA) are largely absent. The present study evaluated a middle-size patient cohort who underwent percutaneous coronary intervention (PCI) with stent implantation and follow-up coronary angiography (CAG) and tested the hypothesis that increased plasma level of high-sensitive CRP would indicate rapid progression of de novo non-target coronary artery lesions in Chinese patients with SA.Methods The study population comprised of 311 consecutive patients with chronic SA who underwent coronary stent implantation on initial admission and angiographic follow-up ((8.5±1.2) months). Rapid angiographic progression of non-target lesion was angiographically assessed and the patients were classified into two groups according to whether the progression existed or not. The relation of plasma CRP levels to the progression of atherosclerosis was investigated.Results Baseline demographic, clinical, and angiographic data were similar in patients with and without progression.Rapid angiographic progression of non-target lesions occurred in 136 patients (43.7%) at follow-up: 77 had a ≥10%diameter reduction of pre-existing stenosis ≥50%, 26 had a ≥30% diameter reduction of a pre-existing stenosis <50%, 64 developed a new lesion ≥30% in a previously normal segment, and 4 had progression of a lesion to total occlusion.Progression of non-target lesions was not associated with target lesion restenosis formation. High-sensitive CRP levels were markedly higher in progression patients than in non-progression ones (1.60 (0.80-3.46) mg/L vs. 0.96 (0.55-1.87)mg/L, P <0.001). Multivariate regression analysis showed that plasma CRP independently predicted rapid angiographic progression of non-target lesions (P=0.001). High-sensitive CRP levels above 1.32 mg

  13. The redshift evolution of massive galaxy clusters in the MACSIS simulations

    Science.gov (United States)

    Barnes, David J.; Kay, Scott T.; Henson, Monique A.; McCarthy, Ian G.; Schaye, Joop; Jenkins, Adrian

    2017-02-01

    We present the MAssive ClusterS and Intercluster Structures (MACSIS) project, a suite of 390 clusters simulated with baryonic physics that yields realistic massive galaxy clusters capable of matching a wide range of observed properties. MACSIS extends the recent BAryons and HAloes of MAssive Systems simulation to higher masses, enabling robust predictions for the redshift evolution of cluster properties and an assessment of the effect of selecting only the hottest systems. We study the observable-mass scaling relations and the X-ray luminosity-temperature relation over the complete observed cluster mass range. As expected, we find that the slope of these scaling relations and the evolution of their normalization with redshift depart significantly from the self-similar predictions. However, for a sample of hot clusters with core-excised temperatures kBT ≥ 5 keV, the normalization and the slope of the observable-mass relations and their evolution are significantly closer to self-similar. The exception is the temperature-mass relation, for which the increased importance of non-thermal pressure support and biased X-ray temperatures leads to a greater departure from self-similarity in the hottest systems. As a consequence, these also affect the slope and evolution of the normalization in the luminosity-temperature relation. The median hot gas profiles show good agreement with observational data at z = 0 and z = 1, with their evolution again departing significantly from the self-similar prediction. However, selecting a hot sample of clusters yields profiles that evolve significantly closer to the self-similar prediction. In conclusion, our results show that understanding the selection function is vital for robust calibration of cluster properties with mass and redshift.

  14. Undetectable plasma viral load predicts normal survival in HIV-2-infected people in a West African village

    Directory of Open Access Journals (Sweden)

    Ricard Dominique

    2010-05-01

    Full Text Available Abstract Background There have been no previous studies of the long-term survival and temporal changes in plasma viral load among HIV-2 infected subjects. Methods 133 HIV-2 infected and 158 HIV-uninfected subjects from a rural area in North-west Guinea-Bissau, West Africa were enrolled into a prospective cohort study in 1991 and followed-up to mid-2009. Data were collected on four occasions during that period on HIV antibodies, CD4% and HIV-2 plasma viral load. Results Median age (interquartile range [IQR] of HIV-2 infected subjects at time of enrollment was 47 (36, 60 years, similar to that of HIV-uninfected control subjects, 49 (38, 62 (p = 0.4. Median (IQR plasma viral load and CD4 percentage were 347 (50, 4,300 copies/ml and 29 (22, 35 respectively. Overall loss to follow-up to assess vital status was small, at 6.7% and 6.3% for HIV-2 infected and uninfected subjects respectively. An additional 17 (12.8% and 16 (10.1% of HIV-2 infected and uninfected subjects respectively were censored during follow-up due to infection with HIV-1. The mortality rate per 100 person-years (95% CI was 4.5 (3.6, 5.8 among HIV-2 infected subjects compared to 2.1 (1.6, 2.9 among HIV-uninfected (age-sex adjusted rate ratio 1.9 (1.3, 2.8, p Viral load measurements were available for 98%, 78%, 77% and 61% HIV-2 infected subjects who were alive and had not become super-infected with HIV-1, in 1991, 1996, 2003 and 2006 respectively. Median plasma viral load (RNA copies per ml (IQR did not change significantly over time, being 150 (50, 1,554; n = 77 in 1996, 203 (50, 2,837; n = 47 in 2003 and 171 (50, 497; n = 31 in 2006. Thirty seven percent of HIV-2 subjects had undetectable viraemia ( Conclusions A substantial proportion of HIV-2 infected subjects in this cohort have stable plasma viral load, and those with an undetectable viral load (37% at study entry had a normal survival rate. However, the sequential laboratory findings need to be interpreted with caution given

  15. Plasma pentraxin 3 levels do not predict coronary events but reflect metabolic disorders in patients with coronary artery disease in the CARE trial.

    Science.gov (United States)

    Miyazaki, Tetsuro; Chiuve, Stephanie; Sacks, Frank M; Ridker, Paul M; Libby, Peter; Aikawa, Masanori

    2014-01-01

    Chronic inflammation closely associates with obesity, metabolic syndrome, diabetes mellitus, and atherosclerosis. Evidence indicates that the immunomodulator pentraxin 3 (PTX3) may serve as a biomarker of these cardiometabolic disorders, but whether PTX3 predicts cardiovascular complications is unknown. We examined the association of plasma PTX3 levels with recurrent coronary events via a prospective, nested, case-control design in the CARE trial. Among 4159 patients who had a prior myocardial infarction 3 to 20 months before enrollment and also had total cholesterol levels metabolic disorders. Low plasma PTX3 levels correlated with high body-mass index, waist circumference, and triglycerides; and with low HDL cholesterol. Overall, PTX3 levels correlated inversely with the number of metabolic syndrome components. PTX3 levels also correlated inversely with apoCIII and tissue plasminogen activator, but did not associate with CRP. Although the study further links low PTX3 levels with various features associated with metabolic syndrome, the results do not indicate that PTX3 can predict recurrent coronary events among MI survivors.

  16. An Empirical Model for the Galaxy Luminosity and Star-Formation Rate Function at High Redshift

    CERN Document Server

    Mashian, Natalie; Loeb, Abraham

    2015-01-01

    Using the most recent measurements of the ultraviolet (UV) luminosity functions (LFs) and dust estimates of early galaxies, we derive updated dust-corrected star-formation rate functions (SFRFs) at z~4-8, which we model to predict the evolution to higher redshifts, z>8. We employ abundance matching techniques to calibrate a relation between galaxy star formation rate (SFR) and host halo mass M{_h} by mapping the shape of the observed SFRFs at z~4-8 to that of the halo mass function. The resulting scaling law remains roughly constant over this redshift range. We apply the average SFR-M{_h} relation to reproduce the observed SFR functions at 4 10 indicate that JWST will be able to detect galaxies out to z~15 with an extensive treasury sized program. We also derive the redshift evolution of the star formation rate density and associated reionization history by galaxies for which we find that the inclusion of galaxies with SFRs well below the current detection limit leads to a fully reionized universe by z~6.5 an...

  17. Diagnosing galactic feedback with the line broadening in the low redshift Lyman-alpha forest

    CERN Document Server

    Viel, M; Bolton, J S; Kim, T -S; Puchwein, E; Nasir, F; Wakker, B P

    2016-01-01

    We compare the low redshift (z ~ 0.1) Lyman-alpha forest from hydrodynamical simulations with data from the Cosmic Origin Spectrograph (COS). We find tension between the observed number of lines with b-parameters in the range 25-45 km/s and the predictions from simulations that incorporate either vigorous feedback from active galactic nuclei or that exclude feedback altogether. The gas in these simulations is, respectively, either too hot to contribute to the Lyman-alpha absorption or too cold to produce the required line widths. Matching the observed b-parameter distribution therefore requires feedback processes that thermally or turbulently broaden the absorption features without collisionally (over-)ionising hydrogen. This suggests the Lyman-alpha forest b-parameter distribution is a valulable diagnostic of galactic feedback in the low redshift Universe. We furthermore confirm the low redshift Lyman-alpha forest column density distribution is better reproduced by an ultraviolet background with an HI photo-...

  18. Deriving photometric redshifts using fuzzy archetypes and self-organizing maps - I. Methodology

    Science.gov (United States)

    Speagle, Joshua S.; Eisenstein, Daniel J.

    2017-07-01

    We propose a method to substantially increase the flexibility and power of template fitting-based photometric redshifts by transforming a large number of galaxy spectral templates into a corresponding collection of 'fuzzy archetypes' using a suitable set of perturbative priors designed to account for empirical variation in dust attenuation and emission-line strengths. To bypass widely separated degeneracies in parameter space (e.g. the redshift-reddening degeneracy), we train self-organizing maps (SOMs) on large 'model catalogues' generated from Monte Carlo sampling of our fuzzy archetypes to cluster the predicted observables in a topologically smooth fashion. Subsequent sampling over the SOM then allows full reconstruction of the relevant probability distribution functions (PDFs). This combined approach enables the multimodal exploration of known variation among galaxy spectral energy distributions with minimal modelling assumptions. We demonstrate the power of this approach to recover full redshift PDFs using discrete Markov chain Monte Carlo sampling methods combined with SOMs constructed from Large Synoptic Survey Telescope ugrizY and Euclid YJH mock photometry.

  19. Interpreting the observed UV continuum slopes of high-redshift galaxies

    CERN Document Server

    Wilkins, Stephen M; Coulton, William; Croft, Rupert; Di Matteo, Tiziana; Khandai, Nishikanta; Feng, Yu

    2013-01-01

    The observed UV continuum slope of star forming galaxies is strongly affected by the presence of dust. Its observation is then a potentially valuable diagnostic of dust attenuation, particularly at high-redshift where other diagnostics are currently inaccesible. Interpreting the observed UV continuum slope in the context of dust attenuation is often achieved assuming the empirically calibrated Meurer et al. (1999) relation. Implicit in this relation is the assumption of an intrinsic UV continuum slope ($\\beta=-2.23$). However, results from numerical simulations suggest that the intrinsic UV continuum slopes of high-redshift star forming galaxies are bluer than this, and moreover vary with redshift. Using values of the intrinsic slope predicted by numerical models of galaxy formation combined with a Calzetti et al. (2000) reddening law we infer UV attenuations ($A_{1500}$) $0.35-0.5\\,{\\rm mag}$ ($A_{V}$: $0.14-0.2\\,{\\rm mag}$ assuming Calzetti et al. 2000) greater than simply assuming the Meurer relation. This...

  20. The relation between mass and concentration in X-ray galaxy clusters at high redshift

    CERN Document Server

    Amodeo, Stefania; Capasso, Raffaella; Sereno, Mauro

    2016-01-01

    Galaxy clusters are the most recent, gravitationally-bound products of the hierarchical mass accretion over cosmological scales. How the mass is concentrated is predicted to correlate with the total mass in the cluster's halo, with systems at higher mass being less concentrated at given redshift and for any given mass, systems with lower concentration are found at higher redshifts. Through a spatial and spectral X-ray analysis, we reconstruct the total mass profile of 47 galaxy clusters observed with Chandra in the redshift range $0.40.4$, and is well suited to provide the first constraint on the concentration--mass relation at $z>0.7$ from X-ray analysis. Under the assumptions that the distribution of the X-ray emitting gas is spherically symmetric and in hydrostatic equilibrium, we combine the deprojected gas density and spectral temperature profiles through the hydrostatic equilibrium equation to recover the parameters that describe a NFW total mass distribution. The comparison with results from weak lensi...

  1. Redshift-space distortions in massive neutrino and evolving dark energy cosmologies

    CERN Document Server

    Upadhye, Amol; Pope, Adrian; Heitmann, Katrin; Habib, Salman; Finkel, Hal; Frontiere, Nicholas

    2015-01-01

    Large-scale structure surveys in the coming years will measure the redshift-space power spectrum to unprecedented accuracy, allowing for powerful new tests of the LambdaCDM picture as well as measurements of particle physics parameters such as the neutrino masses. We extend the Time-RG perturbative framework to redshift space, computing the power spectrum P_s(k,mu) in massive neutrino cosmologies with time-dependent dark energy equations of state w(z). Time-RG is uniquely capable of incorporating scale-dependent growth into the P_s(k,mu) computation, which is important for massive neutrinos as well as modified gravity models. Although changes to w(z) and the neutrino mass fraction both affect the late-time scale-dependence of the non-linear power spectrum, we find that the two effects depend differently on the line-of-sight angle mu. Finally, we use the HACC N-body code to quantify errors in the perturbative calculations. For a LambdaCDM model at redshift z=1, our procedure predicts the monopole~(quadrupole) ...

  2. The distribution of neutral hydrogen around high-redshift galaxies and quasars in the EAGLE simulation

    CERN Document Server

    Rahmati, Alireza; Bower, Richard G; Crain, Robert A; Furlong, Michelle; Schaller, Matthieu; Theuns, Tom

    2015-01-01

    The observed high covering fractions of neutral hydrogen (HI) with column densities above $\\sim 10^{17} \\rm{cm}^{-2}$ around Lyman-Break Galaxies (LBGs) and bright quasars at redshifts z ~ 2-3 has been identified as a challenge for simulations of galaxy formation. We use the EAGLE cosmological, hydrodynamical simulation, which has been shown to reproduce a wide range of galaxy properties and for which the subgrid feedback was calibrated without considering gas properties, to study the distribution of HI around high-redshift galaxies. We predict the covering fractions of strong HI absorbers ($N_{\\rm{HI}} \\gtrsim 10^{17} \\rm{cm}^{-2}$) inside haloes to increase rapidly with redshift but to depend only weakly on halo mass. For massive ($M_{200} \\gtrsim 10^{12} {\\rm M_{\\odot}}$) halos the covering fraction profiles are nearly scale-invariant and we provide fitting functions that reproduce the simulation results. While efficient feedback is required to increase the HI covering fractions to the high observed values...

  3. Stacking for machine learning redshifts applied to SDSS galaxies

    OpenAIRE

    Zitlau, Roman; Hoyle, Ben; Paech, Kerstin; Weller, Jochen; Rau, Markus Michael; Seitz, Stella

    2016-01-01

    We present an analysis of a general machine learning technique called 'stacking' for the estimation of photometric redshifts. Stacking techniques can feed the photometric redshift estimate, as output by a base algorithm, back into the same algorithm as an additional input feature in a subsequent learning round. We shown how all tested base algorithms benefit from at least one additional stacking round (or layer). To demonstrate the benefit of stacking, we apply the method to both unsupervised...

  4. Cosmological simulations of the high-redshift radio universe

    OpenAIRE

    Kawata, Daisuke; Gibson, Brad K.; Windhorst, Rogier A.

    2004-01-01

    Using self-consistent cosmological simulations of disc galaxy formation, we analyse the 1.4 GHz radio flux from high-redshift progenitors of present-day normal spirals within the context of present-day and planned next-generation observational facilities. We demonstrate that while current radio facilities such as the Very Large Array (VLA) are unlikely to trace these progenitors beyond redshifts z

  5. Prediction of alpha1-adrenoceptor occupancy in the human prostate from plasma concentrations of silodosin, tamsulosin and terazosin to treat urinary obstruction in benign prostatic hyperplasia.

    Science.gov (United States)

    Yamada, Shizuo; Kato, Yasuhiro; Okura, Takashi; Kagawa, Yoshiyuki; Kawabe, Kazuki

    2007-07-01

    Alpha1-adrenoceptor antagonists are clinically useful for the improvement of urinary obstruction due to benign prostatic hyperplasia (BPH), and their therapeutic effects are mediated through the blockade of prostatic alpha(1)-adrenoceptors. The present study was undertaken to predict the magnitude and duration of alpha(1)-adrenoceptor occupancy in the human prostate after oral alpha(1)-adrenoceptor antagonists. Prostatic alpha(1)-adrenoceptor-binding parameters of silodosin were estimated by measuring specific [(3)H]prazosin binding in rat prostate after oral administration of this drug. The plasma concentration of silodosin after oral administration in rats and healthy volunteers was measured using a high-performance liquid chromatographic method. The alpha(1)-adrenoceptor-binding affinities (K(i)) of silodosin, tamsulosin, and terazosin in the human prostate and plasma concentrations of tamsulosin and terazosin were obtained from the literature. Using the alpha(1)-adrenoceptor binding parameters of silodosin in rat prostate, alpha(1)-adrenoceptor occupancy in the human prostate was estimated to be around 60-70% at 1-6 h after oral administration of silodosin at doses of 3.0, 8.1, and 16.1 micromol. Thereafter, the receptor occupancy was periodically decreased, to 24% (8.1 micromol) and 54% (16.1 micromol) 24 h later. A similar magnitude and time course of alpha(1)-adrenoceptor occupancy by silodosin in the human prostate were estimated using alpha(1)-adrenoceptor-binding affinities (K(i)) in the human prostate. Despite about two orders of differences in the plasma unbound concentrations after clinically effective oral dosages of silodosin, tamsulosin, and terazosin, there was a comparable magnitude of prostatic alpha(1)-adrenoceptor occupancy by these drugs. In conclusion, the prediction of alpha(1)-adrenoceptor occupancy in the human prostate by alpha(1)-adrenoceptor antagonists may provide the rationale for the optimum dosage regimen of these drugs in the

  6. The predictive value of plasma B-type natriuretic peptide levels on outcome in children with pulmonary hypertension undergoing congenital heart surgery

    Directory of Open Access Journals (Sweden)

    Ayse Baysal

    2014-09-01

    Full Text Available Background and objectives: In children undergoing congenital heart surgery, plasma brain natriuretic peptide levels may have a role in development of low cardiac output syndrome that is defined as a combination of clinical findings and interventions to augment cardiac output in children with pulmonary hypertension. Methods: In a prospective observational study, fifty-one children undergoing congenital heart surgery with preoperative echocardiographic study showing pulmonary hypertension were enrolled. The plasma brain natriuretic peptide levels were collected before operation, 12, 24 and 48 h after operation. The patients enrolled into the study were divided into two groups depending on: (1 Development of LCOS which is defined as a combination of clinical findings or interventions to augment cardiac output postoperatively; (2 Determination of preoperative brain natriuretic peptide cut-off value by receiver operating curve analysis for low cardiac output syndrome. The secondary end points were: (1 duration of mechanical ventilation ≥72 h, (2 intensive care unit stay >7days, and (3 mortality. Results: The differences in preoperative and postoperative brain natriuretic peptide levels of patients with or without low cardiac output syndrome (n = 35, n = 16, respectively showed significant differences in repeated measurement time points (p = 0.0001. The preoperative brain natriuretic peptide cut-off value of 125.5 pg mL−1 was found to have the highest sensitivity of 88.9% and specificity of 96.9% in predicting low cardiac output syndrome in patients with pulmonary hypertension. A good correlation was found between preoperative plasma brain natriuretic peptide level and duration of mechanical ventilation (r = 0.67, p = 0.0001. Conclusions: In patients with pulmonary hypertension undergoing congenital heart surgery, 91% of patients with preoperative plasma brain natriuretic peptide levels above 125.5 pg mL−1 are at risk of developing low cardiac

  7. Identification of a liver cirrhosis signature in plasma for predicting hepatocellular carcinoma risk in a population-based cohort of hepatitis B carriers.

    Science.gov (United States)

    Liu, Chia-Chi; Wang, Ya-Hui; Chuang, Eric Y; Tsai, Mong-Hsun; Chuang, Ya-Hui; Lin, Chih-Lin; Liu, Chun-Jen; Hsiao, Bo-Yu; Lin, Shi-Ming; Liu, Li-Yu; Yu, Ming-Whei

    2014-01-01

    Liver cirrhosis is a critical state in the natural course of hepatocellular carcinoma (HCC). We sought to investigate the potential of in-depth proteomics to reveal plasma protein signatures that reflect common networks/pathways of liver cirrhosis, and to determine whether the cirrhosis-related signature in plasma is linked to the development of HCC among hepatitis B virus (HBV) carriers. We first compared plasma protein profiles using a 174-antibody microarray system between three groups of HBV carriers with different Child's grades of cirrhosis, which revealed a panel of 45 differentially expressed proteins with a high accuracy for discriminating Child's B/C. Ingenuity Pathway Analysis identified two main up-regulated networks connecting the 45 proteins that were most enriched for genes in the pathway of hepatic stellate cell activation. A parsimonious subset of 11 pathway-based proteins was then selected for quantification to correlate with HCC risk among 49 HCC cases and 50 controls in a nested case-control study within a 16-yr follow-up cohort of HBV carriers. A high risk score derived from a principal component analysis, which was used to extract the cluster structure of the 11 proteins, was associated with HCC (odds ratio = 4.83, 95% confidence interval: 1.26-18.56) even after adjustment for viral and clinical variables, implying the involvement of a pattern of coordinated proteins. Stepwise logistic regression on the 11 proteins revealed ICAM-2 as an independent predictor for HCC. These findings may give further insight into the pathobiology of hepatocarcinogenesis, allow testing of the cirrhosis-related plasma protein signature as a potential predictive biomarker for HCC.

  8. Modeling of plasma-induced damage during the etching of ultimately-scaled transistors in ULSI circuits--A model prediction of damage in three dimensional structures

    Science.gov (United States)

    Eriguchi, Koji

    2014-10-01

    An increasing demand for high performance field-effect transistors (FETs) leads to the aggressive critical dimension shrinkage and the currently-emerging three dimensional (3D) geometry. Plasma processing is widely used also in the scaled- and 3D-FET (e.g. FinFET) manufacturing, where precise control of the reaction on the (sidewall) surfaces is a prime issue. In this study, damage creation mechanism during plasma etching--plasma-induced physical damage (PPD)--was investigated in such structures on the basis of the PPD range theory, atomistic simulations, and experiments. Compared to PPD in planar FETs (e.g. Si recess [2,3]), a stochastic modeling and atomistic simulations predicted that, during etching of ``fins'' in a 3D-FET, the following two mechanisms are responsible for damage creation in addition to an ion impact on the sidewall at an oblique incident angle: 1) incoming ions penetrate into the Si substrate and undergo scattering by Si atoms in the lateral direction even if the incident angle is normal to the surface and 2) some of Si atoms and ions sputtered at the surface being etched impact on the sidewall with energies sufficient to break Si-Si bonds. These straggling and sputtering processes are stochastic and fundamental, thus, result in 3D structure damage (``fin-damage''). The ``fin-damage'' induced by straggling was modeled by the PPD range theory. Molecular dynamics simulations clarified the mechanisms under the various plasma conditions. Quantum mechanical calculations showed that created defect structures play the role of a carrier trap site, which was experimentally verified by an electrical measurement. Since they are intrinsic natures of etching, both straggling and sputtering noted here should be implemented to design a low-damage etching process. This work was supported in part by Grant-in-Aid for Scientific Research (B) 23360321 from JSPS and STARC project.

  9. On the realistic validation of photometric redshifts

    Science.gov (United States)

    Beck, R.; Lin, C.-A.; Ishida, E. E. O.; Gieseke, F.; de Souza, R. S.; Costa-Duarte, M. V.; Hattab, M. W.; Krone-Martins, A.

    2017-07-01

    Two of the main problems encountered in the development and accurate validation of photometric redshift (photo-z) techniques are the lack of spectroscopic coverage in the feature space (e.g. colours and magnitudes) and the mismatch between the photometric error distributions associated with the spectroscopic and photometric samples. Although these issues are well known, there is currently no standard benchmark allowing a quantitative analysis of their impact on the final photo-z estimation. In this work, we present two galaxy catalogues, Teddy and Happy, built to enable a more demanding and realistic test of photo-z methods. Using photometry from the Sloan Digital Sky Survey and spectroscopy from a collection of sources, we constructed data sets that mimic the biases between the underlying probability distribution of the real spectroscopic and photometric sample. We demonstrate the potential of these catalogues by submitting them to the scrutiny of different photo-z methods, including machine learning (ML) and template fitting approaches. Beyond the expected bad results from most ML algorithms for cases with missing coverage in the feature space, we were able to recognize the superiority of global models in the same situation and the general failure across all types of methods when incomplete coverage is convoluted with the presence of photometric errors - a data situation which photo-z methods were not trained to deal with up to now and which must be addressed by future large-scale surveys. Our catalogues represent the first controlled environment allowing a straightforward implementation of such tests. The data are publicly available within the COINtoolbox (https://github.com/COINtoolbox/photoz_catalogues).

  10. The DEEP2 Galaxy Redshift Survey: Redshift Identification of Single-Line Emission Galaxies

    CERN Document Server

    Kirby, E N; Faber, S M; Koo, D C; Weiner, B J; Cooper, M C

    2007-01-01

    We present two methods for determining spectroscopic redshifts of galaxies in the \\deep survey which display only one identifiable feature, an emission line, in the observed spectrum ("single-line galaxies"). First, we assume each single line is one of the four brightest lines accessible to DEEP2: Halpha, [OIII] 5007, Hbeta, or [OII] 3727. Then, we supplement spectral information with BRI photometry. The first method, parameter space proximity (PSP), calculates the distance of a single-line galaxy to galaxies of known redshift in (B-R), (R-I), R, observed wavelength parameter space. The second method is an artificial neural network (ANN). Prior information, such as allowable line widths and ratios, rules out one or more of the four lines for some galaxies in both methods. Based on analyses of evaluation sets, both methods are nearly perfect at identifying blended [OII] doublets. Of the lines identified as Halpha in the PSP and ANN methods, 91.4% and 94.2% respectively are accurate. Although the methods are no...

  11. On the Number of Galaxies at High Redshift

    Directory of Open Access Journals (Sweden)

    Lorenzo Zaninetti

    2015-09-01

    Full Text Available The number of galaxies at a given flux as a function of the redshift, z, is derived when the z-distance relation is non-standard. In order to compare different models, the same formalism is also applied to the standard cosmology. The observed luminosity function for galaxies of the zCOSMOS catalog at different redshifts is modeled by a new luminosity function for galaxies, which is derived by the truncated beta probability density function. Three astronomical tests, which are the photometric maximum as a function of the redshift for a fixed flux, the mean value of the redshift for a fixed flux, and the luminosity function for galaxies as a function of the redshift, compare the theoretical values of the standard and non-standard model with the observed value. The tests are performed on the FORS Deep Field (FDF catalog up to redshift z = 1.5 and on the zCOSMOS catalog extending beyond z = 4. These three tests show minimal differences between the standard and the non-standard models.

  12. Photometric redshifts for the SDSS Data Release 12

    Science.gov (United States)

    Beck, Róbert; Dobos, László; Budavári, Tamás; Szalay, Alexander S.; Csabai, István

    2016-08-01

    We present the methodology and data behind the photometric redshift data base of the Sloan Digital Sky Survey (SDSS) Data Release 12. We adopt a hybrid technique, empirically estimating the redshift via local regression on a spectroscopic training set, then fitting a spectrum template to obtain K-corrections and absolute magnitudes. The SDSS spectroscopic catalogue was augmented with data from other, publicly available spectroscopic surveys to mitigate target selection effects. The training set is comprised of 1976 978 galaxies, and extends up to redshift z ≈ 0.8, with a useful coverage of up to z ≈ 0.6. We provide photometric redshifts and realistic error estimates for the 208 474 076 galaxies of the SDSS primary photometric catalogue. We achieve an average bias of overline{Δ z_{norm}} = {5.84 × 10^{-5}}, a standard deviation of σ(Δznorm) = 0.0205, and a 3σ outlier rate of Po = 4.11 per cent when cross-validating on our training set. The published redshift error estimates and photometric error classes enable the selection of galaxies with high-quality photometric redshifts. We also provide a supplementary error map that allows additional, sophisticated filtering of the data.

  13. Improving photometric redshifts with Ly$\\alpha$ tomography

    CERN Document Server

    Schmittfull, Marcel

    2016-01-01

    Forming a three dimensional view of the Universe is a long-standing goal of astronomical observations, and one that becomes increasingly difficult at high redshift. In this paper we discuss how tomography of the intergalactic medium (IGM) at $z\\simeq 2.5$ can be used to estimate the redshifts of massive galaxies in a large volume of the Universe based on spectra of galaxies in their background. Our method is based on the fact that hierarchical structure formation leads to a strong dependence of the halo density on large-scale environment. A map of the latter can thus be used to refine our knowledge of the redshifts of halos and the galaxies and AGN which they host. We show that tomographic maps of the IGM at a resolution of $2.5\\,h^{-1}$Mpc can determine the redshifts of more than 90 per cent of massive galaxies with redshift uncertainty $\\Delta z/(1+z)=0.01$. Higher resolution maps allow such redshift estimation for lower mass galaxies and halos.

  14. Cosmological parameters from a million photometric redshifts of SDSS LRGs

    CERN Document Server

    Blake, C; Bridle, S; Lahav, O; Blake, Chris; Collister, Adrian; Bridle, Sarah; Lahav, Ofer

    2006-01-01

    We analyze MegaZ-LRG, a new photometric-redshift catalogue of Luminous Red Galaxies (LRGs) based on the imaging data of the Sloan Digital Sky Survey (SDSS) 4th Data Release. MegaZ-LRG, presented in a companion paper, contains > 10^6 photometric redshifts derived with ANNz, an Artificial Neural Network method, constrained by a spectroscopic sub-sample of ~13,000 galaxies obtained by the 2dF-SDSS LRG and Quasar (2SLAQ) survey. The catalogue spans the redshift range 0.4redshift error ~ 0.03(1+z). We present the first cosmological parameter fits to galaxy angular power spectra from a photometric redshift survey. Combining the redshift slices with appropriate covariances, we determine the matter density Omega_m and baryon density Omega_b in the combinations Omega_m h = 0.20+/-0.03 and Omega_b/Omega_m = 0.14+/-0.04. These results are in agreement with and independent of the latest studies of the Cosmic Microwave Background radiation, and their precision is comparable to analyses of conte...

  15. The Hubble series: Convergence properties and redshift variables

    CERN Document Server

    Cattoen, Celine

    2007-01-01

    In cosmography, cosmokinetics, and cosmology it is quite common to encounter physical quantities expanded as a Taylor series in the cosmological redshift z. Perhaps the most well-known exemplar of this phenomenon is the Hubble relation between distance and redshift. However, we now have considerable high-z data available, for instance we have supernova data at least back to redshift z=1.75. This opens up the theoretical question as to whether or not the Hubble series (or more generally any series expansion based on the z-redshift) actually converges for large redshift? Based on a combination of mathematical and physical reasoning, we argue that the radius of convergence of any series expansion in z is less than or equal to 1, and that z-based expansions must break down for z>1, corresponding to a universe less than half its current size. Furthermore, we shall argue on theoretical grounds for the utility of an improved parameterization y=z/(1+z). In terms of the y-redshift we again argue that the radius of con...

  16. The Hubble series: convergence properties and redshift variables

    Energy Technology Data Exchange (ETDEWEB)

    Cattoen, Celine; Visser, Matt [School of Mathematics, Statistics, and Computer Science, Victoria University of Wellington, PO Box 600, Wellington (New Zealand)

    2007-12-07

    In cosmography, cosmokinetics and cosmology, it is quite common to encounter physical quantities expanded as a Taylor series in the cosmological redshift z. Perhaps the most well-known exemplar of this phenomenon is the Hubble relation between distance and redshift. However, we now have considerable high-z data available; for instance, we have supernova data at least back to redshift z {approx} 1.75. This opens up the theoretical question as to whether or not the Hubble series (or more generally any series expansion based on the z-redshift) actually converges for large redshift. Based on a combination of mathematical and physical reasonings, we argue that the radius of convergence of any series expansion in z is less than or equal to 1, and that z-based expansions must break down for z > 1, corresponding to a universe less than half of its current size. Furthermore, we shall argue on theoretical grounds for the utility of an improved parametrization y = z/(1 + z). In terms of the y-redshift, we again argue that the radius of convergence of any series expansion in y is less than or equal to 1, so that y-based expansions are likely to be good all the way back to the big bang (y = 1), but that y-based expansions must break down for y < -1, now corresponding to a universe more than twice its current size.

  17. Is there a redshift cutoff for submillimetre galaxies?

    CERN Document Server

    Raymond, G; Dye, S; Carlberg, R; Sullivan, M

    2008-01-01

    We present new optical and infrared photometry for a statistically complete sample of seven 1.1 mm selected sources with accurate Submillimetre Array coordinates. We determine photometric redshifts for four of the seven sources of 4.47, 4.50, 1.49 and 0.64. Of the other three sources two are undetected at optical wavelengths down to the limits of very deep Subaru and Canada-France-Hawaii Telescope images ($\\sim$27 mag AB, i band) and the photometry of the remaining source is corrupted by a bright nearby galaxy. The sources with the highest redshifts are at higher redshifts than all but one of the $\\sim$200 sources taken from the largest recent 850 $\\mu$m surveys, which may indicate that 1.1 mm surveys are more efficient at finding sources at very high redshifts than 850 $\\mu$m surveys. We investigate the evolution of the number density with redshift of our sample using a banded $V_{e}/V_{a}$ analysis and find no evidence for a redshift cutoff, although the number of sources is very small. We also perform the ...

  18. Photometric redshifts of galaxies from SDSS and 2MASS

    Institute of Scientific and Technical Information of China (English)

    Tao Wang; Jia-Sheng Huang; Qiu-Sheng Gu

    2009-01-01

    In order to find the physical parameters which determine the accuracy of pho- tometric redshifts, we compare the spectroscopic and photometric redshifts (photo-z's) for a large sample of ~ 80 000 SDSS-2MASS galaxies. Photo-z's in this paper are es- timated by using the artificial neural network photometric redshift method (ANNz). For a subset of~40000 randomly selected galaxies, we find that the photometric redshift recovers the spectroscopic redshifi distribution very well with rms of 0.016. Our main results are as follows: (1) Using magnitudes directly as input parameters produces more accurate photo-z's than using colors; (2) The inclusion of 2MASS (3, H, Ks) bands does not improve photo-z's significantly, which indicates that near infrared data might not be important for the low-redshift sample; (3) Adding the concentration index (essentially the steepness of the galaxy brightness profile) as an extra input can improve the photo-z's estimation up to~10 percent; (4) Dividing the sample into early- and late-type galaxies by using the concentration index, normal and abnormal galaxies by using the emission line flux ratios, and red and blue galaxies by using color index (g - r), we can improve the accuracy of photo-z's significantly; (5) Our analysis shows that the outliers (where there is a big difference between the spectroscopic and photometric redshifts) are mainly correlated with galaxy types, e.g., most outliers are late-type (blue) galaxies.

  19. Spectral Confusion for Cosmological Surveys of Redshifted C II Emission

    Science.gov (United States)

    Kogut, A.; Dwek, E.; Moseley, S. H.

    2015-01-01

    Far-infrared cooling lines are ubiquitous features in the spectra of star-forming galaxies. Surveys of redshifted fine-structure lines provide a promising new tool to study structure formation and galactic evolution at redshifts including the epoch of reionization as well as the peak of star formation. Unlike neutral hydrogen surveys, where the 21 cm line is the only bright line, surveys of redshifted fine-structure lines suffer from confusion generated by line broadening, spectral overlap of different lines, and the crowding of sources with redshift. We use simulations to investigate the resulting spectral confusion and derive observing parameters to minimize these effects in pencilbeam surveys of redshifted far-IR line emission. We generate simulated spectra of the 17 brightest far-IR lines in galaxies, covering the 150-1300 µm wavelength region corresponding to redshifts 0 C II] line and other lines. Although the [C II] line is a principal coolant for the interstellar medium, the assumption that the brightest observed lines in a given line of sight are always [C II] lines is a poor approximation to the simulated spectra once other lines are included. Blind line identification requires detection of fainter companion lines from the same host galaxies, driving survey sensitivity requirements. The observations require moderate spectral resolution 700 < R < 4000 with angular resolution between 20? and 10', sufficiently narrow to minimize confusion yet sufficiently large to include a statistically meaningful number of sources.

  20. Spectroscopy of moderately high-redshift RCS-1 clusters

    CERN Document Server

    Gilbank, David G; Blindert, K; Ellingson, E; Gladders, M D; Yee, H K C

    2007-01-01

    We present spectroscopic observations of 11 moderately high-redshift (z~0.7- 1.0) clusters from the first Red-Sequence Cluster Survey (RCS-1). We find excellent agreement between the red-sequence estimated redshift and the spectroscopic redshift, with a scatter of 10% at z>0.7. At the high-redshift end (z>~0.9) of the sample, we find two of the systems selected are projections of pairs of comparably rich systems, with red-sequences too close to discriminate in (R-z') colour. In one of these systems, the two components are close enough to be physically associated. For a subsample of clusters with sufficient spectroscopic members, we examine the correlation between B_gcR (optical richness) and the dynamical mass inferred from the velocity dispersion. We find these measurements to be compatible, within the relatively large uncertainties, with the correlation established at lower redshift for the X-ray selected CNOC1 clusters and also for a lower redshift sample of RCS-1 clusters. Confirmation of this and calibra...