WorldWideScience

Sample records for plant-derived biologics seminar

  1. Biological Physics : Poincaré seminar

    CERN Document Server

    Bio-physique : séminaire Poincaré

    2011-01-01

    This new volume in the Poincaré Seminar Series, describing recent developments at the interface between physics and biology, is directed towards a broad audience of physicists, biologists, and mathematicians. Both the theoretical and experimental aspects are covered, and particular care is devoted to the pedagogical nature of the presentations. The first survey article, by Jean-Francois Joanny and Jacques Prost, describes the theoretical advances made in the study of "active gels", with applications to liquid crystals and cell motility. Jasper van der Gucht and Cécile Sykes then report on recent advances made with biomimetic model systems in the understanding of cytokinesis. The next article, by Jonathon Howard, presents several molecular models for motor proteins, which are compared with experimental results for kinesin. David Lacoste and Kirone Mallick then show theoretically that similar ratchet models of motor proteins naturally satisfy a fundamental time-reversal symmetry, the Gallavotti-Cohen fluctuat...

  2. Quantification of the plant-derived hallucinogen Salvinorin A in conventional and non-conventional biological fluids by gas chromatography/mass spectrometry after Salvia divinorum smoking.

    Science.gov (United States)

    Pichini, Simona; Abanades, Sergio; Farré, Magí; Pellegrini, Manuela; Marchei, Emilia; Pacifici, Roberta; Torre, Rafael de la; Zuccaro, Piergiorgio

    2005-01-01

    A gas chromatography method with mass spectrometric detection is described for the determination of Salvinorin A, the main active ingredient of the hallucinogenic mint Salvia divinorum. The method was validated in plasma, urine, saliva and sweat using 17-alpha-methyltestosterone as internal standard. The analytes were extracted from biological matrices with chloroform/isopropanol (9:1, v/v). Chromatography was performed on a 5% phenyl methyl silicone capillary column and analytes were determined in the selected ion monitoring mode. The method was validated over the concentration range 0.015-5 microg/mL plasma, urine and saliva and 0.01-5 microg/patch in the case of sweat. Mean recoveries ranged between 77.1 and 92.7% for Salvinorin A in different biological matrices, with precision and accuracy always better than 15%. The method was applied to the analysis of urine, saliva and sweat from two consumers after smoking 75 mg plant leaves to verify the presence of the active ingredient of S. divinorum in human biological fluids as a biomarker of plant consumption. Salvinorin A was detected in urine (2.4 and 10.9 ng/mL) and saliva (11.1 and 25.0 ng/mL), but not in sweat patches from consumers.

  3. Proceedings of the 182nd basic science seminar (The workshop on neutron structural biology ) 'New frontiers of structural biology advanced by solution scattering'

    Energy Technology Data Exchange (ETDEWEB)

    Fujiwara, Satoru (ed.) [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    2001-03-01

    182nd advanced science seminar (the workshop on neutron structural biology) was held in February 9-10, 2000 at Tokai. Thirty-six participants from universities, research institutes, and private companies took part in the workshop, and total of 24 lectures were given. This proceedings collects abstracts, the figures and tables, which the speakers used in their lectures. The proceedings contains two reviews from the point of view of x-ray and neutron scatterings, and six subjects (21 papers) including neutron and x-ray scattering in the era of structure genomics, structural changes detected with solution scattering, a new way in structural biology opened by neutron crystallography and neutron scattering, x-ray sources and detectors, simulation and solution scattering, and neutron sources and detectors. (Kazumata, Y.)

  4. 2013 Gordon Research Conference on metals in biology and seminar on bioinorganic chemistry

    Energy Technology Data Exchange (ETDEWEB)

    Rosenzweig, Amy C. [Northwestern Univ., Evanston, IL (United States)

    2013-01-25

    Typical topics for lectures and posters include: biochemical and biophysical characterization of new metal containing proteins, enzymes, nucleic acids, factors, and chelators from all forms of life; synthesis, detailed characterization, and reaction chemistry of biomimetic compounds; novel crystal and solution structures of biological molecules and synthetic metal-chelates; discussions of the roles that metals play in medicine, maintenance of the environment, and biogeochemical processes; metal homeostasis; application of theory and computations to the structure and mechanism of metal-containing biological systems; and novel applications of spectroscopy to metals in biological systems.

  5. Plant-derived nanostructures: types and applications

    Science.gov (United States)

    Plant-derived nanostructures and nanoparticles (NPs) have functional applications in numerous disciplines such as health care, food and feed, cosmetics, biomedical science, energy science, drug-gene delivery, environmental health, and so on. Consequently, it is imperative for res...

  6. Seminar / Piret Kruuspere

    Index Scriptorium Estoniae

    Kruuspere, Piret, 1961-

    1999-01-01

    23.-25. aug. toimus rahvusvaheline seminar, mille üldteemaks teatri suhted urbanistlike struktuuridega. Seminar sai teoks Eesti Teatriuurijate ühenduse, Helsingi Ülikooli ja Tallinnas asuva Soome Instituudi koostöös

  7. Nutrient Control Seminars

    Science.gov (United States)

    These Nutrient Control Seminars will present an extensive state-of-the-technology review of the engineering design and operation of nitrogen and phosphorous control technologies and techniques applied at municipal wastewater treatment plants (WWTPs). These seminars will present ...

  8. Plant-derived recombinant human serum transferrin demonstrates multiple functions.

    Science.gov (United States)

    Brandsma, Martin E; Diao, Hong; Wang, Xiaofeng; Kohalmi, Susanne E; Jevnikar, Anthony M; Ma, Shengwu

    2010-05-01

    Human serum transferrin (hTf) is the major iron-binding protein in human plasma, having a vital role in iron transport. Additionally, hTf has many other uses including antimicrobial functions and growth factor effects on mammalian cell proliferation and differentiation. The multitask nature of hTf makes it highly valuable for different therapeutic and commercial applications. However, the success of hTf in these applications is critically dependent on the availability of high-quality hTf in large amounts. In this study, we have developed plants as a novel platform for the production of recombinant (r)hTf. We show here that transgenic plants are an efficient system for rhTf production, with a maximum accumulation of 0.25% total soluble protein (TSP) (or up to 33.5 microg/g fresh leaf weight). Furthermore, plant-derived rhTf retains many of the biological activities synonymous with native hTf. In particular, rhTf reversibly binds iron in vitro, exhibits bacteriostatic activity, supports cell proliferation in serum-free medium and can be internalized into mammalian cells in vitro. The success of this study validates the future application of plant rhTf in a variety of fields. Of particular interest is the use of plant rhTf as a novel carrier for cell-specific or oral delivery of protein/peptide drugs for the treatment of human diseases such as diabetes.To demonstrate this hypothesis, we have additionally expressed an hTf fusion protein containing glucagon-like peptide 1 (GLP-1) or its derivative in plants. Here, we show that plant-derived hTf-GLP-1 fusion proteins retain the ability to be internalized by mammalian cells when added to culture medium in vitro.

  9. Technical Training Seminar

    CERN Multimedia

    2003-01-01

    Wednesday 19 November From 9:30 to 17:30 - IT Amphitheatre bldg.31 3-004 2003 Data Transmission Design Seminar - TEXAS INSTRUMENTS The one-day 2003 Data Transmission Design Seminar is part of a series of technical seminars produced by Texas Instruments. This series of seminars will introduce system solutions based on different standards according to their respective requirements. It will include topics containing a blend of basic principles and hands-on application examples, along with layout-guidelines. • Basics and Practical Examples of Data-Transmission • Low Voltage Differential Signaling (LVDS) • Connectivity and PC-based Links • Industrial Interfaces • Parallel Bus Systems and Clock-Distribution-Circuits (CDC) This Seminar will be of interest to hardware designers and system engineers dealing with the realization of system- or board-level interfaces based on various transmission standards. Language: English Free seminar, no registration Organiser: John ...

  10. AMAS Robotics Seminar Brief

    Science.gov (United States)

    2011-07-19

    Unclassified Unclassified 19 July 2011 AMAS ROBOTICS SEMINAR BRIEF Aaron Hart, Product Integrator, RS JPO DISTRIBUTION STATEMENT A. Approved for...19-07-2011 to 19-07-2011 4. TITLE AND SUBTITLE robotics seminar brief 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6...12. DISTRIBUTION/AVAILABILITY STATEMENT Approved for public release; distribution unlimited 13. SUPPLEMENTARY NOTES AMAS ROBOTICS SEMINAR BRIEF 14

  11. Plant-derived bioactive compounds produced by endophytic fungi.

    Science.gov (United States)

    Zhao, J; Shan, T; Mou, Y; Zhou, L

    2011-02-01

    Plant endophytic fungi are an important and novel resource of natural bioactive compounds with their potential applications in agriculture, medicine and food industry. In the past two decades, many valuable bioactive compounds with antimicrobial, insecticidal, cytotoxic, and anticancer activities have been successfully discovered from endophytic fungi. During the long period of co-evolution, a friendly relationship was formed between each endophyte and its host plant. Some endophytes have the ability to produce the same or similar bioactive compounds as those originated from their host plants. This review mainly deals with the research progress on endophytic fungi for producing plant-derived bioactive compounds such as paclitaxel, podophyllotoxin, camptothecine, vinblastine, hypericin, and diosgenin. The relations between endophytic fungi and their host plants, biological activities and action mechanisms of these compounds from endophytic fungi, some available strategies for efficiently promoting production of these bioactive compounds, as well as their potential applications in the future will also be discussed. It is beneficial for us to better understand and take advantage of plant endophytic fungi.

  12. The mucosal immune response to plant-derived vaccines.

    Science.gov (United States)

    Hefferon, Kathleen Laura

    2010-10-01

    Transgenic plants present enormous potential as one of the most cost-effective and safe systems for large-scale production of proteins for industrial, pharmaceutical, veterinary and agricultural uses. Heat-stable plant-derived vaccines that are administered orally could in effect enhance vaccine coverage in children and infants, particularly in developing countries. Here we discuss the current status of plant-derived vaccines and their potential to champion the battle against infectious diseases in the least developed countries.

  13. Seminars: didactic proposal for teaching Genetics

    Directory of Open Access Journals (Sweden)

    Cibele Marli Cação Paiva Gouvêa

    2015-12-01

    Full Text Available The aim of this work was to use seminars taught by a group of students of the Biological Sciences of the Federal University of Alfenas and compare with a group that did not taught seminars, showing that the strategy has contributed to the teaching/learning process of the first group, in addition to other skills. The seminars focused on topics from Genetics, were chosen, prepared and presented by students, under the guidance of the professor in charge of the discipline. The seminar presentations were opened to the entire academic community and were followed by discussion with the participants. The results of this study showed that students who presented the seminars have obtained better grades in Genetics than the students that have not presented the seminars, indicating better Genetics knowledge fixation, in addition to Genetics knowledge dissemination to the participant public. The action has promoted the development of skills such as the autonomy of thought and action, the ability to integrate new and old elements of the diverse knowledge areas, the group working and problem solving.

  14. Phytoestrogens: Plant-derived Estrogenic Compounds

    Directory of Open Access Journals (Sweden)

    Nevzat Konar

    2011-12-01

    Full Text Available Estrogen is a hormone, which is produced in ovary and testis; however, it has many biological effects besides the reproductive system. Phytoestrogens are the compounds, which have estrogen-like structure and activities, taking place in structure of various edible plants at different levels and in different compositions. These compounds attracted notice after the first quarter of 20th century upon they had been associated with infertility seen in some of animals fed with alfalfa, and these compounds have been identified in human-derived biological samples and its effects on health have been taken under study in the recent 30 years. These materials have especially antioxidant role in plants while they have activities in animals and humans as estrogen agonist and antagonists. Based on their chemical structure, they may be gathered under especially isoflavon and lignan groups while some of members of coumestan and stilbene groups are also identified as phytoestrogenic compound.

  15. Virtual Seminar Room

    DEFF Research Database (Denmark)

    Forchhammer, Søren Otto; Fosgerau, Anders; Hansen, Peter Søren Kirk

    1999-01-01

    The initial design considerations and research goals for an ATM network based virtual seminar room with 5 sites are presented.......The initial design considerations and research goals for an ATM network based virtual seminar room with 5 sites are presented....

  16. EUROTHERM Seminar No. 18

    CERN Document Server

    Heggs, Peter; Butterworth, David

    1992-01-01

    The Eurotherm Committee was created in 1986 from member countries of the European Community. It has the purpose of organising and coordinating scientific events such as seminars and conferences in the thermal sciences. The series of Eurotherm Seminars established by the Committee has become a popular forum for high-level scientific and technical interchange of ideas in a wide range of specialist topics. While the presentation and publication of papers at the Seminars are encouraged, the primary aim is to stimulate discussion and liaison between specialist groups. The present Chairman of Eurotherm is Professor C.J. Hoogendoorn of the Technical University, Delft (Fax [NL] 15, 783251). Information on Mure Seminars is available from the Secretary, Keith Cornwell, Heriot-Watt University, Edinburgh (Fax [UK] 31, 451, 3129). This particular Seminar No. 18 on the Design and Operation of Heat Exchangers was the first one on this topic and was held at the Universitat der Bundeswehr Hamburg (University of the Federal Ar...

  17. Astronomy Research Seminar

    Science.gov (United States)

    Johson, Jolyon; Genet, Russell; Armstrong, James; Boyce, Grady; Boyce, Pat; Brewer, Mark; Buchheim, Robert; Carro, Joseph; Estrada, Reed; Estrada, Chris; Freed, Rachel; Gillette, Sean; Harshaw, Richard; Hollis, Thomas; Kenney, John; McGaughey, Seven; McNab, Christine; Mohanan, Kakkala; Sepulveda, Babs; Wallace, Dan; Wallen, Vera

    2015-05-01

    Traditional science lectures and labs are often enhanced through project- and team-based learning. Some students go beyond these classroom studies by conducting research, often under the guidance of university professors. A one-semester astronomy research seminar was initiated in 2006 in collaboration with the community of professional and amateur double star astronomers. The result was dozens of jointly-authored papers published in the Journal of Double Star Observations and the Annual Proceedings of the Society of Astronomical Sciences. This seminar, and its affiliated community, launched a series of conferences and books, providing students with additional forums to share their double star research. The original seminar, and its derivatives, enhanced educational careers through college admissions and scholarships. To expand the seminar's reach, it was restructured from a few teams at one school, to many teams, each from a different school. A volunteer from each school became an assistant instructor. Most of them were seminar veterans, experienced astronomers, or science teachers. The assistant instructors, in turn, recruited enthusiastic students for their teams. To avoid student and instructor overload, the seminar focused on its three deliverables: a formal proposal, published paper, and public PowerPoint presentation. Future seminars may offer other astronomical research options such as exoplanet transit or eclipsing binary photometry.

  18. Seminar proceedings. Seminar on piping reliability

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-10-01

    The international seminar brought together the disciplines of probabilistic safety assessment and probabilistic fracture mechanics. The work performed by the joint Nordic Nuclear Safety Research Project NKS/RAK 1.2 and the SLAP project was presented the first day. The second was mainly devoted to the integration of the two disciplines. 11 contributions have been separately indexed.

  19. Agrobacterium tumefaciens responses to plant-derived signaling molecules

    Directory of Open Access Journals (Sweden)

    Sujatha eSubramoni

    2014-07-01

    Full Text Available As a special phytopathogen, Agrobacterium tumefaciens infects a wide range of plant hosts and causes plant tumors also known as crown galls. The complexity of Agrobacterium-plant interaction has been studied for several decades. Agrobacterium pathogenicity is largely attributed to its evolved capabilities of precise recognition and response to plant-derived chemical signals. Agrobacterium perceives plant-derived signals to activate its virulence genes, which are responsible for transferring and integrating its T-DNA (Transferred DNA from its Tumour-inducing (Ti plasmid into the plant nucleus. The expression of T-DNA in plant hosts leads to the production of a large amount of indole-3-acetic acid (IAA, cytokinin (CK and opines. IAA and CK stimulate plant growth, resulting in tumor formation. Agrobacterium utilizes opines as nutrient sources as well as signals in order to activate its quorum sensing (QS to further promote virulence and opine metabolism. Intriguingly, Agrobacterium also recognizes plant-derived signals including -amino butyric acid (GABA and salicylic acid (SA to activate quorum quenching that reduces the level of QS signals, thereby avoiding the elicitation of plant defense and preserving energy. In addition, Agrobacterium hijacks plant-derived signals including SA, IAA, and ethylene (ET to down-regulate its virulence genes located on the Ti plasmid. Moreover, certain metabolites from corn (Zea mays also inhibit the expression of Agrobacterium virulence genes. Here we outline the responses of Agrobacterium to major plant-derived signals that impact Agrobacterium-plant interactions.

  20. Plant-Derived Natural Products for Parkinson's Disease Therapy.

    Science.gov (United States)

    Sengupta, T; Vinayagam, J; Singh, R; Jaisankar, P; Mohanakumar, K P

    2016-01-01

    Plant-derived natural products have made their own niche in the treatment of neurological diseases since time immemorial. Parkinson's disease (PD), the second most prevalent neurodegenerative disorder, has no cure and the treatment available currently is symptomatic. This chapter thoughtfully and objectively assesses the scientific basis that supports the increasing use of these plant-derived natural products for the treatment of this chronic and progressive disorder. Proper considerations are made on the chemical nature, sources, preclinical tests and their validity, and mechanisms of behavioural or biochemical recovery observed following treatment with various plants derived natural products relevant to PD therapy. The scientific basis underlying the neuroprotective effect of 6 Ayurvedic herbs/formulations, 12 Chinese medicinal herbs/formulations, 33 other plants, and 5 plant-derived molecules have been judiciously examined emphasizing behavioral, cellular, or biochemical aspects of neuroprotection observed in the cellular or animal models of the disease. The molecular mechanisms triggered by these natural products to promote cell survivability and to reduce the risk of cellular degeneration have also been brought to light in this study. The study helped to reveal certain limitations in the scenario: lack of preclinical studies in all cases barring two; heavy dependence on in vitro test systems; singular animal or cellular model to establish any therapeutic potential of drugs. This strongly warrants further studies so as to reproduce and confirm these reported effects. However, the current literature offers scientific credence to traditionally used plant-derived natural products for the treatment of PD.

  1. COMBINE 2 seminar

    DEFF Research Database (Denmark)

    Sørensen, Lars Schiøtt; Jacobsen, Kim

    1995-01-01

    A seminar about the COMBINE project was described. Further, the project was described in generel, i.e. the COMBINE´s data model (IDM), the data exchange system (DES) and the different I/O-systems included in COMBINE 2......A seminar about the COMBINE project was described. Further, the project was described in generel, i.e. the COMBINE´s data model (IDM), the data exchange system (DES) and the different I/O-systems included in COMBINE 2...

  2. Plant derived antioxidants and antifibrotic drugs: past, present and future

    Directory of Open Access Journals (Sweden)

    Devaraj Ezhilarasan

    2014-09-01

    Full Text Available Hepatic fibrosis occurs as a wound-healing process after several forms of chronic hepatic injury. Activation and proliferation of hepatic stellate cells play pivotal role in the pathogenesis of hepatic fibrosis. Many researchers, from the therapeutic perspective, have focused their attention on searching for novel agents with inhibitory effects on hepatic stellate cells proliferation and activation to prevent hepatic fibrogenesis and a number of plant derived antioxidants have been tested as anti-fibrogenic agents, they generally suppress proliferation and collagen synthesis. Plants remain an imperative source of novel drugs, novel drug leads and new chemical entities. The plant based drug discovery resulted primarily in the development of antioxidant, anti-cancer and other anti-infectious agents and continues to contribute to the new leads in clinical trials. This review summarizes some of those most important plant derived anti-fibrotic drugs and their beneficial effects on experimentally induced hepatic fibrosis in vitro and in vivo. The plant derived antioxidant compounds described herein are curcumin, silymarin, silibinin, baicalein, resveratrol, salvianolic acids, tetrandine, quercetin and berberine. Studies from ours and as demonstrated by pervious workers much information has been accumulated over the past two decades through in vivo and in vitro. In light of those studies, it has been confirmed that plants derived antioxidants, particularly flavanoids, show a significant influence to block hepatic fibrosis regardless of any etiology. This review outlines recent progress in the use of plant derived drugs against experimentally induced liver fibrosis by in vitro and in vivo studies and summarizes the possible mechanisms anti-fibrotic effects of these compounds.

  3. Preparation for Retirement Seminar

    CERN Multimedia

    HR Department

    2009-01-01

    The Human Resources Department is organizing a preparation for retirement seminar, which will take place on the afternoons of the 11, 13, 25 and 27 November 2009. Similar seminars in the past have always proved highly successful. Retirement marks the end of a person’s working life and the start of a new chapter. This period of transition is experienced differently from one individual to another. In all cases, being well-informed and prepared greatly facilitates the change in lifestyle. We would like to draw your attention to the following information: Staff concerned: All staff members aged 58 and above have been sent a personal invitation to attend. Spouses are welcome. Staff members below 58 who are interested in attending the seminar may also apply. Their applications will be accepted subject to availability of places. Registration: In view of the number of people concerned and the limited capacity of the main auditorium, you are requested to register in advance via ...

  4. Preparation for Retirement Seminar

    CERN Multimedia

    HR Department

    2009-01-01

    The Human Resources Department is organizing a preparation for retirement seminar, which will take place in the afternoons of 11, 13, 25 and 27 November 2009. Similar seminars in the past have always proved highly successful. Retirement marks the end of a person’s working life and the start of a new chapter. This period of transition is experienced differently from one individual to another. In all cases, being well-informed and prepared greatly facilitates the change in lifestyle. We would like to draw your attention to the following information: Staff concerned: All staff members aged 58 and above have been sent a personal invitation to attend. Spouses are welcome. Staff members below 58 who are interested in attending the seminar may also apply. Their applications will be accepted subject to the availability of places. Registration: In view of the number of people concerned and the limited capacity of the Main Auditorium, you are requested to register in advance via Ind...

  5. Preparation for Retirement Seminar

    CERN Multimedia

    HR Department

    2009-01-01

    The Human Resources Department is organizing a preparation for retirement seminar, which will take place on the afternoons of the 11, 13, 25 and 27 November 2009. Similar seminars in the past have always proved highly successful. Retirement marks the end of a person’s working life and the start of a new chapter. This period of transition is experienced differently from one individual to another. In all cases, being well-informed and prepared greatly facilitates the change in lifestyle. We would like to draw your attention to the following information: Staff concerned: All staff members aged 58 and above have been sent a personal invitation to attend. Spouses are welcome. Staff members below 58 who are interested in attending the seminar may also apply. Their applications will be accepted subject to the availability of places. Registration: In view of the number of people concerned and the limited capacity of the Main Auditorium, you are requested to register in advance ...

  6. Preparation for Retirement Seminar

    CERN Multimedia

    HR Department

    2009-01-01

    The Human Resources Department is organizing a preparation for retirement seminar, which will take place on the afternoons of the 11, 13, 25 and 27 November 2009. Similar seminars in the past have always proved highly successful. Retirement marks the end of a person’s working life and the start of a new chapter. This period of transition is experienced differently from one individual to another. In all cases, being well-informed and prepared greatly facilitates the change in lifestyle. We would like to draw your attention to the following information: Staff concerned: All staff members aged 58 and above have been sent a personal invitation to attend. Spouses are welcome. Staff members under the age of 58 who are interested in attending the seminar may also apply. Their applications will be accepted subject to the availability of places. Registration: In view of the number of people concerned and the limited capacity of the Main Auditorium, you are requested to register ...

  7. Preparation for Retirement Seminar

    CERN Multimedia

    HR Department

    2009-01-01

    The Human Resources Department is organizing a preparation for retirement seminar, which will take place on the afternoons of the 11, 13, 25 and 27 November 2009. Similar seminars in the past have always proved highly successful. Retirement marks the end of a person’s working life and the start of a new chapter. This period of transition is experienced differently from one individual to another. In all cases, being well-informed and prepared greatly facilitates the change in lifestyle. We would like to draw your attention to the following information: Staff concerned: All staff members aged 58 and above have been sent a personal invitation to attend. Spouses are welcome. Staff members under the age of 58 who are interested in attending the seminar may also apply. Their applications will be accepted subject to the availability of places. Registration: In view of the number of people concerned and the limited capacity of the Main Auditorium, you are requested to register ...

  8. Preparation for Retirement Seminar

    CERN Multimedia

    HR Department

    2009-01-01

    The Human Resources Department is organizing a preparation for retirement seminar, which will take place on the afternoons of the 11, 13, 25 and 27 November 2009. Similar seminars in the past have always proved highly successful. Retirement marks the end of a person’s working life and the start of a new chapter. This period of transition is experienced differently from one individual to another. In all cases, being well-informed and prepared greatly facilitates the change in lifestyle. We would like to draw your attention to the following information: Staff concerned: All staff members aged 58 and above have been sent a personal invitation to attend. Spouses are welcome. Staff members below 58 who are interested in attending the seminar may also apply. Their applications will be accepted subject to the availability of places. Registration: In view of the number of people concerned and the limited capacity of the Main Auditorium, you are requested to register in advance ...

  9. Plant derived and dietary phenolic antioxidants: anticancer properties.

    Science.gov (United States)

    Roleira, Fernanda M F; Tavares-da-Silva, Elisiário J; Varela, Carla L; Costa, Saul C; Silva, Tiago; Garrido, Jorge; Borges, Fernanda

    2015-09-15

    In this paper, a review of the literature on the phenolic compounds with anticancer activity published between 2008 and 2012 is presented. In this overview only phenolic antioxidant compounds that display significant anticancer activity have been described. In the first part of this review, the oxidative and nitrosative stress relation with cancer are described. In the second part, the plant-derived food extracts, containing identified phenolic antioxidants, the phenolic antioxidants isolated from plants and plant-derived food or commercially available and the synthetic ones, along with the type of cancer and cells where they exert anticancer activity, are described and summarized in tables. The principal mechanisms for their anti-proliferative effects were also described. Finally, a critical analysis of the studies and directions for future research are included in the conclusion. Copyright © 2015 Elsevier Ltd. All rights reserved.

  10. Genetic instability of sugarcane plants derived from meristem cultures

    Directory of Open Access Journals (Sweden)

    Zucchi Maria Imaculada

    2002-01-01

    Full Text Available The RADP (Random amplified polymorphic DNA technique was used to detect tissue-culture-induced variations in sugarcane. Plants of the Brazilian variety RB83-5486 propagated via rhizomes and via meristem cultures were studied. The polymorphism rate for 98 RAPD loci was 6.93% when the plants derived from meristems. Besides, in order to evaluate the influence of the number of subcultures on the generation of somaclonal variation, field-grown RB83-5486 plants derived from 10 meristems were studied after five subcultivations. Although different rates of polymorphism were observed, there was no direct association with the stage of subcultivation. The analysis of plants of two sugarcane varieties cultivated in vitro from meristems showed that variety RB83-5486 was more unstable than variety SP80-185.

  11. TECHNICAL TRAINING SEMINAR

    CERN Multimedia

    Davide Vitè

    2002-01-01

    Wednesday 6 March TECHNICAL TRAINING SEMINAR from 9:30 to 16:45 - IT Amphitheatre - bldg. 31.3.004 Analog Devices DSP Day Thorsten Kistler (Application Engineer), Steffen Boerner (Product Specialist) / ANALOG DEVICES Munich Trying to meet your design challenges, Analog Devices compiles application information and offers chipsets, software, reference designs and mixed-signal, application specific DSPs, for a range of real-time signal processing applications. This seminar will present the latest 16bit fixed-point and 32bit floating-point DSPs (roadmaps; internal architectures, blocks, features benchmarks), with their software, development kits and emulators: Fixed-Point DSP-Family, ADSP-218x and ADSP-219x Blackfin DSP SHARC-Family, 2106x and 2116x TigerSHARC Industrial Contact: François Caloz, Sasco-Spoerle GmbH Language: English Free seminar, no registration Organiser: Davide Vitè / HR-TD / 75141 Davide.Vite@cern.ch Please read the full information on the Technical Training Seminars...

  12. [A seminar for thinking?].

    Science.gov (United States)

    Touzet, Patrick

    2014-01-01

    The sociopolitical context in which we carry out our caregiving profession influences our methods of working. In our world marked by rationalism, thinking about care, in the framework of a seminar, is a way of engaging ourselves and of not simply becoming a functionary of care.

  13. Add value products of honeybee plant-derived origin

    OpenAIRE

    Iop, Silvia C.F.; Ramalhosa, Elsa; Dotto, Dalva M.R.; Cirolini, Andreia; Beltrami, Naiane

    2016-01-01

    Although honey extraction is an ancient practíce, its use as a source of income is more recent. Over the years several techniques have been developed to achieve greater amounts of honey and also to ensure the quality of the product. Furthermore, bees during their life cycle produce wax, royal jelly, pollen and propolis besides honey. Pollen and propolis are such as honey, plant derivatives, while the wax and royal jelly are products secreted by glands of the bees. This chapter aims to pres...

  14. Indoor climate seminar. Sisaeilmastoseminaari

    Energy Technology Data Exchange (ETDEWEB)

    Seppaenen, O. (ed.) (Helsinki Univ. of Technology, Otaniemi (Finland). Lab. of Heating, Ventilation and Air Conditioning)

    1990-01-01

    The national energy research programme LVIS-2000: Future Building Services is concerned with the control of energy use and indoor climate in buildings of the future. The projects were presented at a one day seminar arranged by the Laboratory of Heating and Ventilation of the Technical Research Centre in Finland which is coordinating the programme. The topics presented at the seminar were: The effect of indoor air on health in office buildings, The effect of air temperature on performance of office work, Emissions from building and interior materials, Experiences of odour panels in indoor climate research, Mould spores and bacteries in the indoor air of rural houses, Ventilation systems in future buildings, Demonstration project of ventilation systems in a block of flats.

  15. Indoor climate seminar; Sisaeilmastoseminaari

    Energy Technology Data Exchange (ETDEWEB)

    Seppaenen, O. [ed.] [Helsinki Univ. of Technology, Otaniemi (Finland). Lab. of Heating, Ventilation and Air Conditioning

    1990-12-31

    The national energy research programme LVIS-2000: Future Building Services is concerned with the control of energy use and indoor climate in buildings of the future. The projects were presented at a one day seminar arranged by the Laboratory of Heating and Ventilation of the Technical Research Centre in Finland which is coordinating the programme. The topics presented at the seminar were: The effect of indoor air on health in office buildings, The effect of air temperature on performance of office work, Emissions from building and interior materials, Experiences of odour panels in indoor climate research, Mould spores and bacteries in the indoor air of rural houses, Ventilation systems in future buildings, Demonstration project of ventilation systems in a block of flats.

  16. Preparation for Retirement Seminar

    CERN Multimedia

    HR Department

    2007-01-01

    The Department of Human Resources is organising a preparation for retirement seminar which will take place on the four successive afternoons of 2 to 5 October 2007. Similar seminars in the past have always proved highly successful. Retirement marks the end of one’s working life and the start of a new period of life. This period of transition and change is experienced differently from one individual to another. In any case, being well-informed and prepared greatly facilitates the change in lifestyle. We would like to draw your attention to the following information: Staff concerned: All staff members aged 58 and above as well as those who have retired during the year have been sent a personal invitation to attend. Spouses are welcome. Staff members below 58 who are interested in attending the seminar may also apply. Their applications will be accepted subject to availability of places. Registration: In view of the number of people concerned and the limited capacity of th...

  17. Preparation for retirement seminar

    CERN Multimedia

    HR Department

      The Human Resources Department is organizing a preparation for retirement seminar, which will take place on the afternoons of the 25 and 27 November 2009. Similar seminars in the past have always proved highly successful. Retirement marks the end of a person’s working life and the start of a new chapter. This period of transition is experienced differently from one individual to another. In all cases, being well-informed and prepared greatly facilitates the change in lifestyle. We would like to draw your attention to the following information: Staff concerned: All staff members aged 58 and above have been sent a personal invitation to attend. Spouses are welcome. Staff members under the age of 58 who are interested in attending the seminar may also apply. Their applications will be accepted subject to the availability of places. Registration: In view of the number of people concerned and the limited capacity of the Main Auditorium, you are requested to register in advance via Indico. &a...

  18. TECHNICAL TRAINING SEMINAR

    CERN Multimedia

    Davide VITÈ

    2002-01-01

    Wednesday 6 March   from 9:30 to 16:45 - IT Auditorium - bldg. 31 3-004 Analog Devices DSP Day Thorsten Kistler (Application Engineer), Steffen Boerner (Product Specialist) / ANALOG DEVICES Munich Trying to meet your design challenges, Analog Devices compiles application information and offers chipsets, software, reference designs and mixed-signal, application specific DSPs, for a range of real-time signal processing applications. This seminar will present the latest 16bit fixed-point and 32bit floating-point DSPs (roadmaps; internal architectures, blocks, features benchmarks), with their software, development kits and emulators: Fixed-Point DSP-Family, ADSP-218x and ADSP-219x Blackfin DSP SHARC-Family, 2106x and 2116x TigerSHARC Industrial Contact: François Caloz, Sasco-Spoerle GmbH Language: English Free seminar, no registration Organiser: Davide Vitè / HR-TD / 75141 Davide.Vite@cern.ch Please read the full information on the Technical Training Seminars pages here or con...

  19. TECHNICAL TRAINING SEMINAR

    CERN Multimedia

    Davide Vitè

    2002-01-01

    Wednesday 6 March from 9:30 to 16:45 - IT Auditorium - bldg. 31 3-004 Analog Devices DSP Day Thorsten Kistler (Application Engineer), Steffen Boerner (Product Specialist) / ANALOG DEVICES Munich Trying to meet your design challenges, Analog Devices compiles application information and offers chipsets, software, reference designs and mixed-signal, application specific DSPs, for a range of real-time signal processing applications. This seminar will present the latest 16bit fixed-point and 32bit floating-point DSPs (roadmaps; internal architectures, blocks, features benchmarks), with their software, development kits and emulators: Fixed-Point DSP-Family, ADSP-218x and ADSP-219x Blackfin DSP SHARC-Family, 2106x and 2116x TigerSHARC Industrial Contact: François Caloz, Sasco-Spoerle GmbH Language: English Free seminar, no registration Organiser: Davide Vitè / HR-TD / 75141 Davide.Vite@cern.ch Please read the full information on the Technical Training Seminars pages here or contact the organiser.

  20. Preparation for Retirement Seminar

    CERN Multimedia

    HR Department

    2011-01-01

    The Human Resources Department is organizing a Preparation for Retirement Seminar, which will take place on 18 and 21 October 2011 in the afternoon in the Main Auditorium and on 19 October and 15 and 16 November 2011 in the afternoon in the Council Chamber. Similar seminars in the past have always proved highly successful. Retirement marks the end of a person’s working life and the start of a new chapter. This period of transition is experienced differently from one individual to another. In all cases, being well-informed and prepared greatly facilitates the change in lifestyle. We would like to draw your attention to the following information: Staff concerned: All staff members aged 58 and above have been sent a personal invitation to attend. Spouses are welcome. Staff members under the age of 58 who are interested in attending the seminar may also apply. Their applications will be accepted subject to availability of places. Registration: In view of the number of people concerned, you are ...

  1. Preparation for Retirement Seminar

    CERN Multimedia

    HR Department

    2011-01-01

    The Human Resources Department is organizing a Preparation for Retirement Seminar, which will take place on 18 and 21 October 2011 in the afternoon in the Main Auditorium and on 19 October and 15 and 16 November 2011 in the afternoon in the Council Chamber. Similar seminars in the past have always proved highly successful. Retirement marks the end of a person’s working life and the start of a new chapter. This period of transition is experienced differently from one individual to another. In all cases, being well-informed and prepared greatly facilitates the change in lifestyle. We would like to draw your attention to the following information: Staff concerned: All staff members aged 58 and above have been sent a personal invitation to attend. Spouses are welcome. Staff members under the age of 58 who are interested in attending the seminar may also apply. Their applications will be accepted subject to availability of places. Registration: In view of the number of people concerned, you are r...

  2. Naine kui tarbekaup - seminar inimkaubandusest / Katri Tammekand

    Index Scriptorium Estoniae

    Tammekand, Katri

    2003-01-01

    12. detsembril 2002.a. toimus TPÜ-s sotsiaalteaduskonna üliõpilasnõukogu eestvedamisel ja sotsiaalteaduskonna uuringu- ja arengufondi toetusel seminar "Naine kui tarbekaup - seminar inimkaubandusest"

  3. Virology Interest Group Seminar | Center for Cancer Research

    Science.gov (United States)

    Virology Interest Group Seminar.  September 7th, Building 50, Room 2328 from 3:00 until 4:00.   We will have two presenters. Dr. Vladimir Majerciak: The full transcription map of mouse papillomavirus type 1 (MmuPV1), Tumor Virus RNA Biology Section, RNA Biology Laboratory, NCI Dr. Zhi-Ming Zheng: Viral DNA replication regulates HPV18 transcription and gene expression, Tumor Virus RNA Biology Section, RNA Biology Laboratory, NCI    

  4. Plant-Derived Agents for Counteracting Cisplatin-Induced Nephrotoxicity

    Science.gov (United States)

    Venkataraman, Balaji; Kurdi, Amani; Mahgoub, Eglal; Sadek, Bassem

    2016-01-01

    Cisplatin (CSP) is a chemotherapeutic agent commonly used to treat a variety of malignancies. The major setback with CSP treatment is that its clinical efficacy is compromised by its induction of organ toxicity, particular to the kidneys and ears. Despite the significant strides that have been made in understanding the mechanisms underlying CSP-induced renal toxicity, advances in developing renoprotective strategies are still lacking. In addition, the renoprotective approaches described in the literature reveal partial amelioration of CSP-induced renal toxicity, stressing the need to develop potent combinatorial/synergistic agents for the mitigation of renal toxicity. However, the ideal renoprotective adjuvant should not interfere with the anticancer efficacy of CSP. In this review, we have discussed the progress made in utilizing plant-derived agents (phytochemicals) to combat CSP-induced nephrotoxicity in preclinical studies. Furthermore, we have also presented strategies to utilize phytochemicals as prototypes for the development of novel renoprotective agents for counteracting chemotherapy-induced renal damage.

  5. The Efficacy of Seminar Courses

    Science.gov (United States)

    Tsui, Lisa; Gao, Eleanor

    2007-01-01

    This study explores the relationship between the seminar course model and critical thinking development among students through qualitative data collected from four strategically chosen case study institutions. Results of a cross-case analysis suggest that the seminar approach provides fertile ground for the cultivation of critical thinking skills…

  6. Bioanalysis: challenges and solutions seminar.

    Science.gov (United States)

    Roberts, Andrew

    2011-09-01

    Industry challenges and solutions for bioanalysis were top of the agenda for the Spring Seminar organized by Quotient Bioresearch in Munich, Germany. The seminar was attended by representatives from pharmaceutical and biotechnology organisations across Europe and featured debates and panel discussions from leading industry speakers on new techniques and hot topics, including the latest industry guidelines.

  7. Arbejdspapir til Thesis-seminar

    DEFF Research Database (Denmark)

    Damkjaer, Maja Sonne

    2014-01-01

    Arbejdspapir til Thesis-seminar afholdt ved Forskningsseminar i Forskningsprogrammet: Medier, Kommunikation og Samfund, Institut for Æstetik og Kommunikation, Aarhus Universitet. Afhandlingens teoretiske afsnit.......Arbejdspapir til Thesis-seminar afholdt ved Forskningsseminar i Forskningsprogrammet: Medier, Kommunikation og Samfund, Institut for Æstetik og Kommunikation, Aarhus Universitet. Afhandlingens teoretiske afsnit....

  8. Seminar series on Safety matters

    CERN Multimedia

    HSE

    2010-01-01

    The HSE - Occupational Health & Safety and Environmental Protection - Unit is starting a seminar series on Safety matters. The aim is to invite colleagues from Universities, Industries or Government Agencies to share their experience. The seminars will take place in intervals of several months. Part of the Seminars will be held in the form of a Forum where participants can discuss and share views with persons who manage, teach or research Safety matters elsewhere. You are invited to the first Safety Seminar on 22nd September 2010 at 10h00 in building 40 S2 A1 "Salle Andersson" L’Ecole Polytechnique Fédérale de Lausanne (EPFL) will present the way safety is managed in their research institution. Some aspects of research in physics and chemical laboratories will also be presented. The seminar will be given by Dr Thierry Meyer, Head of OHS at FSB-EPFL and Dr Amela Groso, responsible for the safety of the physics institutes

  9. Technical Training Seminar

    CERN Multimedia

    2003-01-01

    Thursday 4 September From 14:00 to 17:00 - Training Centre Auditorium bldg. 593, room 11 The Summit Design VisualElite 4.0 Release Jean Marie St Paul / SUMMIT DESIGN, Europe, Technical Manager Michel Delcroix / SUMMIT DESIGN, Southern Europe, Sales F-95015 CERGY PONTOISE, France Summit Design is an important EDA digital hardware design tool supplier, and the industry leader in the emerging Electronic System Level design domain. Its VisualElite program has been used at CERN for several years. This seminar will include the highlights of the program's latest release. It will be illustrated how Summit Design products can provide a high-level C/C++ and SystemC functional modelling design and verification environment, enabling engineers to analyse system concepts before the implementation stage. The seminar will show how mixed SystemC and HDL simulation can be done, along with solutions for hardware/software development. • HDL new features: Connectivity Table Editor. Xemacs full integration. New NCsim ...

  10. Preparation for retirement seminar

    CERN Multimedia

    HR Department

    2010-01-01

    (Health insurance and wealth and succession planning) During the preparation for retirement seminar in November 2009, the sessions on health insurance in Switzerland and in France unfortunately had to be postponed. Participants in the seminar also expressed interest in an information session on “How to manage your wealth and organize your succession”. The sessions on health insurance will be held on 16 March 2010 and those on managing wealth and succession on 18 March 2010. Programme for Tuesday 16 March 2010 (TH Theory Conference Room, Building 4/3-006): 09:00 Health insurance in Switzerland by Mr. Sandro Breitenstein, Service de l'Assurance Maladie du Canton de Genève 10:00 Coffee break 10:20 Health insurance in France by Mr. Dominique Curtiaud, Caisse Primaire d'Assurance Maladie de l'Ain Programme for Thursday 18 March 2010 (TH Theory Conference Room, Building 4/3-006): 09:00 How to manage your wealth and organize your succession in Switzerland by Mr. Jean-Marc W...

  11. Technical Training Seminar

    CERN Multimedia

    2003-01-01

    Thursday 4 September From 14:00 to 17:00 - Training Centre Auditorium bldg. 593, room 11 The Summit Design VisualElite 4.0 Release Jean Marie St Paul / SUMMIT DESIGN, Europe, Technical Manager Michel Delcroix / SUMMIT DESIGN, Southern Europe, Sales F-95015 CERGY PONTOISE, France Summit Design is an important EDA digital hardware design tool supplier, and the industry leader in the emerging Electronic System Level design domain. Its VisualElite program has been used at CERN for several years. This seminar will include the highlights of the program's latest release. It will be illustrated how Summit Design products can provide a high-level C/C++ and SystemC functional modelling design and verification environment, enabling engineers to analyse system concepts before the implementation stage. The seminar will show how mixed SystemC and HDL simulation can be done, along with solutions for hardware/software development. • HDL new features: Connectivity Table Editor. Xemacs full integration. New NCsi...

  12. Electromagnetic Simulation Seminar and Opera/Tosca update Seminar

    CERN Multimedia

    IT Department

    2012-01-01

    9 May 2012 Kjell Johnsen Auditorium – Room 30-7-018 Electromagnetic Simulation Seminar & Opera/Tosca update Seminar By Cobham Technical Services – Vector Fields Software Virtual prototyping using electromagnetic simulation software plays an important role in the design stage of many devices and the Opera software has been in use for this purpose at CERN for over a decade. A technical seminar will take place concerning the latest developments in electromagnetic design, analysis and multi-physics applications for large scientific experiments.  Information will be presented on applications such as superconducting magnets and ion-beam sources. The seminar will be presented by engineers/physicists from Cobham Technical Services – Vector Fields Software who develop the Opera program.  It is FREE to attend and is open to both current Opera software users and also those who wish to expand their knowledge and understand better the capabilities on offer. Prog...

  13. Plant derived alternatives for hormone replacement therapy (HRT).

    Science.gov (United States)

    Seidlova-Wuttke, Dana; Jarry, Hubertus; Wuttke, Wolfgang

    2013-12-01

    Abstract Hormone replacement therapy (HRT) has undisputable positive effects on climacteric complaints, in the bone and on body weight but also several undesired side effects. Therefore, plant-derived alternatives are currently promoted. Phytoestrogens - primarily the isoflavones genistein, daidzein and coumestrol, stemming from soy (Glycine max) or red clover (Trifolium pratense) - were suggested to have the desired but not the undesired effects of estrogens. Most recently published placebo-controlled studies question the beneficial effects. When taken at the time of puberty however, phytoestrogens appear to protect against mammary cancer later in life. Extracts from the rhizome of Cimicifuga racemosa (black cohosh) have no estrogenic effects. In a narrow dose range they have beneficial effects on climacteric complaints, which are due to several compounds with dopaminergic, noradrenergic, serotoninergic and GABAergic actions that act together in the hypothalamus. Ecdysone is produced by several plants, including spinach (Spinacia oleracea) and was very early on shown to increase muscle mass. Later it became apparent that spinach extracts containing ecdysone decreased body fat load, thereby reducing secretion of proinflammatory cytokines by visceral adipocytes and oxidative stress. This had beneficial effects on body weight and serum lipids not only in obese postmenopausal but also in premenopausal women and in men. For the above-described plant extracts, solid placebo-controlled clinical trials are available. For other plant extracts claiming beneficial effects on climacteric complaints or postmenopausal diseases, no solid data are available.

  14. Plant-Derived Human Collagen Scaffolds for Skin Tissue Engineering

    Science.gov (United States)

    Willard, James J.; Drexler, Jason W.; Das, Amitava; Roy, Sashwati; Shilo, Shani; Shoseyov, Oded

    2013-01-01

    Tissue engineering scaffolds are commonly formed using proteins extracted from animal tissues, such as bovine hide. Risks associated with the use of these materials include hypersensitivity and pathogenic contamination. Human-derived proteins lower the risk of hypersensitivity, but possess the risk of disease transmission. Methods engineering recombinant human proteins using plant material provide an alternate source of these materials without the risk of disease transmission or concerns regarding variability. To investigate the utility of plant-derived human collagen (PDHC) in the development of engineered skin (ES), PDHC and bovine hide collagen were formed into tissue engineering scaffolds using electrospinning or freeze-drying. Both raw materials were easily formed into two common scaffold types, electrospun nonwoven scaffolds and lyophilized sponges, with similar architectures. The processing time, however, was significantly lower with PDHC. PDHC scaffolds supported primary human cell attachment and proliferation at an equivalent or higher level than the bovine material. Interleukin-1 beta production was significantly lower when activated THP-1 macrophages where exposed to PDHC electrospun scaffolds compared to bovine collagen. Both materials promoted proper maturation and differentiation of ES. These data suggest that PDHC may provide a novel source of raw material for tissue engineering with low risk of allergic response or disease transmission. PMID:23298216

  15. Polymeric Plant-derived Excipients in Drug Delivery

    Directory of Open Access Journals (Sweden)

    Josias H. Hamman

    2009-07-01

    Full Text Available Drug dosage forms contain many components in addition to the active pharmaceutical ingredient(s to assist in the manufacturing process as well as to optimise drug delivery. Due to advances in drug delivery technology, excipients are currently included in novel dosage forms to fulfil specific functions and in some cases they directly or indirectly influence the extent and/or rate of drug release and absorption. Since plant polysaccharides comply with many requirements expected of pharmaceutical excipients such as non-toxicity, stability, availability and renewability they are extensively investigated for use in the development of solid oral dosage forms. Furthermore, polysaccharides with varying physicochemical properties can be extracted from plants at relatively low cost and can be chemically modified to suit specific needs. As an example, many polysaccharide-rich plant materials are successfully used as matrix formers in modified release dosage forms. Some natural polysaccharides have even shown environmental-responsive gelation characteristics with the potential to control drug release according to specific therapeutic needs. This review discusses some of the most important plant-derived polymeric compounds that are used or investigated as excipients in drug delivery systems.

  16. Plant-Derived Agents for Counteracting Cisplatin-Induced Nephrotoxicity

    Directory of Open Access Journals (Sweden)

    Shreesh Ojha

    2016-01-01

    Full Text Available Cisplatin (CSP is a chemotherapeutic agent commonly used to treat a variety of malignancies. The major setback with CSP treatment is that its clinical efficacy is compromised by its induction of organ toxicity, particular to the kidneys and ears. Despite the significant strides that have been made in understanding the mechanisms underlying CSP-induced renal toxicity, advances in developing renoprotective strategies are still lacking. In addition, the renoprotective approaches described in the literature reveal partial amelioration of CSP-induced renal toxicity, stressing the need to develop potent combinatorial/synergistic agents for the mitigation of renal toxicity. However, the ideal renoprotective adjuvant should not interfere with the anticancer efficacy of CSP. In this review, we have discussed the progress made in utilizing plant-derived agents (phytochemicals to combat CSP-induced nephrotoxicity in preclinical studies. Furthermore, we have also presented strategies to utilize phytochemicals as prototypes for the development of novel renoprotective agents for counteracting chemotherapy-induced renal damage.

  17. Drosophila melanogaster "a potential model organism" for identification of pharmacological properties of plants/plant-derived components.

    Science.gov (United States)

    Panchal, Komal; Tiwari, Anand K

    2017-03-18

    Plants/plant-derived components have been used from ancient times to treat/cure several human diseases. Plants and their parts possess several chemical components that play the vital role in the improvement of human health and their life expectancy. Allopathic medicines have been playing a key role in the treatment of several diseases. Though allopathic medicines provide fast relief, long time consumption cause serious health concerns such as hyperallergic reactions, liver damage, etc. So, the study of medicinal plants which rarely cause any side effect is very important to mankind. Plants contain many health benefit properties like antioxidant, anti-aging, neuroprotective, anti-genotoxic, anti-mutagenic and bioinsecticidal activity. Thus, identification of pharmacological properties of plants/plant-derived components are of utmost importance to be explored. Several model organisms have been used to identify the pharmacological properties of the different plants or active components therein and Drosophila is one of them. Drosophila melanogaster "fruit fly" is a well understood, high-throughput model organism being used more than 110 years to study the different biological aspects related to the development and diseases. Most of the developmental and cell signaling pathways and ∼75% human disease-related genes are conserved between human and Drosophila. Using Drosophila, one can easily analyze the pharmacological properties of plants/plant-derived components by performing several assays available with flies such as survivorship, locomotor, antioxidant, cell death, etc. The current review focuses on the potential of Drosophila melanogaster for the identification of medicinal/pharmacological properties associated with plants/plant-derived components.

  18. EUROTHERM Seminar No. 17

    CERN Document Server

    Lockwood, F; Taine, J

    1991-01-01

    This volume contains the selected papers presented at the EUROTHERM SEMINAR No. 17 - Heat Transfer in Radiating and Combusting Systems held at Cascais from October 8th- 10th, 1990. The EUROTHERM COMMITTEE was created by representatives of the member countries of the European Communities for the organization and coordination of European Scientific events in the field of thermal sciences and their applications. The book is focused on the integration of the heat transfer and combustion. These two subjects have traditionally been considered separate disciplines. In reality, the two are closely interwoven. The central purpose of the book is to generate an effective cross fertilisation of the two at both the fundamental and applied levels. The book reports on: mathematical simulations of heat transfer in reacting systems, new measurements of and measurement techniques for the radiation properties of the intervening medium, and data and theoretical analyses which clarify the physical nature of the complex interactio...

  19. TECHNICAL TRAINING SEMINAR

    CERN Multimedia

    Davide Vitè

    2002-01-01

    Wednesday 15 May 14:00 to 16:00 - Training Centre Auditorium - bldg. 593, room 11 Testing Embedded Software and Systems Ian Smith / SEVEN LAYER COMMUNICATIONS LTD, Edinburgh, Scotland The growing use of embedded processors has resulted in considerable challenges for software and system developers, to ensure that the products they produce function as required, without error. The increasing complexity of these products, and the systems they operate in, adds to the difficulty in testing these products effectively. These challenges will apply to the development of equipment and software for use on the LHC project. This seminar is aimed at anyone involved in the development and/or in the verification of embedded hardware, software or systems at CERN. It will provide an introduction to testing embedded products, and some insights into ways to address the growing complexity of modern embedded products. It will also show some of the methods Seven Layer Communications Ltd. have applied in developing effective test fac...

  20. TECHNICAL TRAINING SEMINAR

    CERN Multimedia

    Davide Vitè

    2002-01-01

    Wednesday 22 May From 14:00 to 17:00 - Training Centre Auditorium - bldg. 593, room 11 Reliability, Availability, Maintainability and Safety (RAMS) Philippe Galley, Vincent Brindejonc / LIGERON S.A., Saint Aubin, France This seminar will address Reliability, Availability, Maintainability and Safety (RAMS) engineering concepts to guarantee availability and safety of critical equipments, in particular in a high technology and R&D environment. Applications of these concepts will be presented. 14h00-14h30 Introduction to Reliability, Availability, Maintainability and Safety activities: general introduction to RAMS, basic definitions, integration of RAMS in a large project. 14h40-16h10 RAMS methodologies: Functional Analysis methodologies Preliminary Hazard Analysis Failure Mode Effects and Criticality Analysis (FMECA) Fault Tree Analysis Use of standards for Reliability predictions Reliability Block Diagrams for a system Advanced models, e.g. Markov's Graphs 16h30-17h00 Presentation of the activ...

  1. All India Seminar on Biomedical Engineering 2012

    CERN Document Server

    Bhatele, Mukta

    2013-01-01

    This book is a collection of articles presented by researchers and practitioners, including engineers, biologists, health professionals and informatics/computer scientists, interested in both theoretical advances and applications of information systems, artificial intelligence, signal processing, electronics and other engineering tools in areas related to biology and medicine in the All India Seminar on Biomedical Engineering 2012 (AISOBE 2012), organized by The Institution of Engineers (India), Jabalpur Local Centre, Jabalpur, India during November 3-4, 2012. The content of the book is useful to doctors, engineers, researchers and academicians as well as industry professionals.

  2. Extraction and downstream processing of plant-derived recombinant proteins.

    Science.gov (United States)

    Buyel, J F; Twyman, R M; Fischer, R

    2015-11-01

    Plants offer the tantalizing prospect of low-cost automated manufacturing processes for biopharmaceutical proteins, but several challenges must be addressed before such goals are realized and the most significant hurdles are found during downstream processing (DSP). In contrast to the standardized microbial and mammalian cell platforms embraced by the biopharmaceutical industry, there are many different plant-based expression systems vying for attention, and those with the greatest potential to provide inexpensive biopharmaceuticals are also the ones with the most significant drawbacks in terms of DSP. This is because the most scalable plant systems are based on the expression of intracellular proteins in whole plants. The plant tissue must therefore be disrupted to extract the product, challenging the initial DSP steps with an unusually high load of both particulate and soluble contaminants. DSP platform technologies can accelerate and simplify process development, including centrifugation, filtration, flocculation, and integrated methods that combine solid-liquid separation, purification and concentration, such as aqueous two-phase separation systems. Protein tags can also facilitate these DSP steps, but they are difficult to transfer to a commercial environment and more generic, flexible and scalable strategies to separate target and host cell proteins are preferable, such as membrane technologies and heat/pH precipitation. In this context, clarified plant extracts behave similarly to the feed stream from microbes or mammalian cells and the corresponding purification methods can be applied, as long as they are adapted for plant-specific soluble contaminants such as the superabundant protein RuBisCO. Plant-derived pharmaceutical proteins cannot yet compete directly with established platforms but they are beginning to penetrate niche markets that allow the beneficial properties of plants to be exploited, such as the ability to produce 'biobetters' with tailored

  3. Single Plant Derived Nanotechnology for Synergistic Antibacterial Therapies

    Science.gov (United States)

    Kalluri, Jhansi R.; Gonzalez-Rodriguez, Roberto; Hartman, Phil S.; Loni, Armando; Canham, Leigh T.; Coffer, Jeffery L.

    2016-01-01

    Multiple new approaches to tackle multidrug resistant infections are urgently needed and under evaluation. One nanotechnology-based approach to delivering new relevant therapeutics involves silicon accumulator plants serving as a viable silicon source in green routes for the fabrication of the nanoscale drug delivery carrier porous silicon (pSi). If the selected plant leaf components contain medicinally-active species as well, then a single substance can provide not only the nanoscale high surface area drug delivery carrier, but the drug itself. With this idea in mind, porous silicon was fabricated from joints of the silicon accumulator plant Bambuseae (Tabasheer) and loaded with an antibacterial extract originating from leaves of the same type of plant (Bambuseae arundinacea). Preparation of porous silicon from Tabasheer includes extraction of biogenic silica from the ground plant by calcination, followed by reduction with magnesium in the presence of sodium chloride, thereby acting as a thermal moderator that helps to retain the mesoporous structure of the feedstock. The purified product was characterized by a combination of scanning electron microscopy (SEM), energy dispersive X-ray analysis (EDX), X-ray diffraction (XRD), Raman spectroscopy, transmission electron microscopy (TEM), and low temperature nitrogen gas adsorption measurements. Antimicrobial activity and minimum inhibitory concentration of a leaf extract of Bambuseae arundinacea was tested against the bacteria Escherichia Coli (E. Coli) and Staphylococcus aureus (S. Aureus), along with the fungus Candida albicans (C. Albicans). A S. aureus active ethanolic leaf extract was loaded into the above Tabasheer-derived porous silicon. Initial studies indicate sustained in vitro antibacterial activity of the extract-loaded plant derived pSi (25 wt %, TGA), as measured by disk diffusion inhibitory zone assays. Subsequent chromatographic separation of this extract revealed that the active antimicrobial species

  4. Detection of contaminating enzymatic activity in plant-derived recombinant biotechnology products.

    Science.gov (United States)

    Brinson, Robert G; Giulian, Gary G; Kelman, Zvi; Marino, John P

    2014-12-02

    Residual impurities in recombinantly produced protein biologics, such as host cell proteins (HCP), can potentially cause unwanted toxic or immunogenic responses in patients. Additionally, undetected impurities found in recombinant proteins used in cell culture may adversely impact basic research and biotechnology applications. Currently, the enzyme-linked immunosorbent assay (ELISA) is the standard for detection of residual HCP contamination in recombinantly produced biologics. Alternatively, two-dimensional liquid chromatography coupled to mass spectrometry is being developed as a tool for assessing this critical quality attribute. Both of these methods rely on the direct detection of HCPs and some previous knowledge of the contaminant. For contaminating enzymes, the mass level of the impurity may fall below the threshold of detection of these methods and underestimate the true impact. To address this point, here we demonstrate facile detection and characterization of contaminating phytase activity in rice-derived recombinant human serum albumin (rHSA) using a sensitive, label-free nuclear magnetic resonance (NMR) spectroscopy assay. We observed varying degrees of phytase contamination in biotechnology-grade rHSA from various manufacturers by monitoring the degradation of adenosine-5'-triphosphate and myo-inositol-1,2,3,4,5,6-hexakisphosphate by (31)P NMR. The observed lot-to-lot variability may result in irreproducible cell culture results and should be evaluated as a possible critical quality attribute in plant-derived biotherapeutics.

  5. TECHNICAL TRAINING SPECIAL SEMINAR

    CERN Multimedia

    Technical Training; Tel. 74924

    2001-01-01

    Wednesday 21 November From 9:00 hrs - bldg. 593 R-010 Linear Design Seminar James Bryant, Eberhard Brunner / ANALOG DEVICES Munich James Bryant, one of the well-known Analog Devices speakers, will present the reasons to use components based on new design processes. Among industrial and high speed applications, a particular focus will be given to single supply and low voltage applications. Eberhard Brunner is the specialist of RF products by Analog Devices. After several years in the US in the component design sector for these products, he will give a tutorial for communication and wireless, and applications based on high speed linear components. 09.00-10.15 Low voltage processes and high precision design techniques; AC and DC signal handling with low voltage and high speed products. 10.30-12.15 How to optimise high speed single supply applications; Single supply products in precision applications; Digital isolation, decoupling and grounding in high speed applications. 13.30-15.15 Communications and wireless, ...

  6. TECHNICAL TRAINING SPECIAL SEMINAR

    CERN Multimedia

    Technical Training; Tel.74924

    2001-01-01

    Wednesday 21 November From 9:00 hrs - Training Centre Auditorium room 11, bldg. 593 Linear Design Seminar James Bryant, Eberhard Brunner / ANALOG DEVICES Munich James Bryant, one of the well-known Analog Devices speakers, will present the reasons to use components based on new design processes. Among industrial and high speed applications, a particular focus will be given to single supply and low voltage applications. Eberhard Brunner is the specialist of RF products by Analog Devices. After several years in the US in the component design sector for these products, he will give a tutorial for communication and wireless, and applications based on high speed linear components. 09.00-10.15 Low voltage processes and high precision design techniques; AC and DC signal handling with low voltage and high speed products. 10.30-12.15 How to optimise high speed single supply applications; Single supply products in precision applications; Digital isolation, decoupling and grounding in high speed applications. 13.30-15.15...

  7. TECHNICAL TRAINING SEMINAR

    CERN Multimedia

    2004-01-01

    Tuesday 3 February 2004 From 09:00 to 13:30 - Training Centre Auditorium - bldg. 593, room 11 USB (Universal Serial Bus) CYPRESS Seminar Claudia Colombini, Field Application Engineer CYPRESS ActiveComp Electronic GmbH D-85077 MANCHING, Germany As a pioneer in USB, CYPRESS sets the standard for cost-effective solutions without sacrificing functionality, performance or reliability. Having shipped over 200 million USB devices, Cypress is the undisputed market leader and demonstrate unmatched USB expertise. With the industry's broadest selection of USB solutions, Cypress has the right silicon, software and support for every USB application, from Low-speed to High-Speed and USB On-The-Go (OTG). • 9:00 - 10:30 Overview of USB systems. USB CYPRESS product overview. Peripherals: Low Speed, Full Speed, High Speed (1.1 and 2.0). Hub Solutions, Embedded Host Solutions, On-The-Go (OTG) and wireless USB. USB Development Tools (first part) • 10:30 - 10:45 coffee • 10:45 - 13:00 (second part)...

  8. TECHNICAL TRAINING SEMINAR

    CERN Multimedia

    2004-01-01

    Tuesday 3 February 2004 From 09:00 to 13:30 - Training Centre Auditorium - bldg. 593, room 11 USB (Universal Serial Bus) CYPRESS Seminar Claudia Colombini, Field Application Engineer CYPRESS ActiveComp Electronic GmbH D-85077 MANCHING, Germany As a pioneer in USB, CYPRESS sets the standard for cost-effective solutions without sacrificing functionality, performance or reliability. Having shipped over 200 million USB devices, Cypress is the undisputed market leader and demonstrate unmatched USB expertise. With the industry's broadest selection of USB solutions, Cypress has the right silicon, software and support for every USB application, from Low-speed to High-Speed and USB On-The-Go (OTG). • 09:00 - 10:30 Overview of USB systems. USB CYPRESS product overview. Peripherals: Low Speed, Full Speed, High Speed (1.1 and 2.0). Hub Solutions, Embedded Host Solutions, On-The-Go (OTG) and wireless USB. USB Development Tools (first part) • 10:30 - 10:45 coffee • 10:45 - 13:00 (second part)...

  9. TECHNICAL TRAINING SEMINAR

    CERN Multimedia

    Davide VITÈ

    2002-01-01

    Wednesday 27 February   from 9:00 to 12:00, LHC Auditorium, bldg. 33 7-018 LabVIEW Real-Time National Instruments, Ennetbaden, Switzerland With LabVIEW Real-Time, you can choose from a variety of RT Series hardware. Add a real-time data acquisition component into a larger measurement and automation system or create a single stand-alone real-time solution with data acquisition, signal conditioning, motion control, RS-232, GPIB instrumentation, and Ethernet connectivity. With the various hardware options, you can create a system to meet your precise needs today, while the modularity of the system means you can add to the solution as your system requirements grow. If you are interested in Reliable and Deterministic systems for Measurement and Automation, you will profit from this seminar. Agenda: Real-Time Overview LabVIEW RT Hardware Platforms - Linux on PXI Programming with LabVIEW RT Real-Time Operating Systems concepts Timing Applications Data Transfer Industrial Contact: Pierre-Andr&ea...

  10. Ethics in Data Sharing (Dagstuhl Seminar 14052)

    OpenAIRE

    Cohen, Julie E.; Dietrich, Sven; Pras, Aiko; Zuck, Lenore D.; Hildebrand Mireille

    2014-01-01

    This report documents the program and the outcomes of Dagstuhl Seminar 14052 "Ethics in Data Sharing". The seminar brought together computer scientists, an ethicist and legal scholars to discuss the topic of "ethics in data sharing."

  11. Preparing for retirement - new seminars

    CERN Multimedia

    Human Resources Department

    2015-01-01

    We would like to take the opportunity to inform you about a new programme related to retirement, organised by the Human Resources Department. Retirement marks the end of a career and the start of a new chapter in life.  In all cases, being well-informed and prepared is necessary to cope successfully with this transition. The programme has been developed for staff members and consists of two seminars: Leaving CERN (half day seminar): short presentations by internal speakers, focusing on what options CERN offers at the end of your career: organised once per year, next session scheduled on 24 November 2015, in the afternoon, enrolment and more information on Indico.   Preparation for retirement (2-day seminar): interactive workshop (in small groups) delivered by external experts, focusing on how to prepare psychologically as well as practically to cope with all the changes retirement brings: organised regularly in 2016, in English or ...

  12. 27 CFR 6.94 - Educational seminars.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Educational seminars. 6.94... OF THE TREASURY LIQUORS âTIED-HOUSEâ Exceptions § 6.94 Educational seminars. An industry member may give or sponsor educational seminars for employees of retailers either at the industry...

  13. Israel Seminar 2002-2003

    CERN Document Server

    Milman, Vitali D

    2004-01-01

    The Israeli GAFA seminar (on Geometric Aspect of Functional Analysis) during the years 2002-2003 follows the long tradition of the previous volumes. It reflects the general trends of the theory. Most of the papers deal with different aspects of the Asymptotic Geometric Analysis. In addition the volume contains papers on related aspects of Probability, classical Convexity and also Partial Differential Equations and Banach Algebras. There are also two expository papers on topics which proved to be very much related to the main topic of the seminar. One is Statistical Learning Theory and the other is Models of Statistical Physics. All the papers of this collection are original research papers.

  14. Israel Seminar 1985-86

    CERN Document Server

    Milman, Vitali

    1987-01-01

    These are the proceedings of the Israel Seminar on the Geometric Aspects of Functional Analysis (GAFA) which was held between October 1985 and June 1986. The main emphasis of the seminar was on the study of the geometry of Banach spaces and in particular the study of convex sets in and infinite-dimensional spaces. The greater part of the volume is made up of original research papers; a few of the papers are expository in nature. Together, they reflect the wide scope of the problems studied at present in the framework of the geometry of Banach spaces.

  15. Consumption and biochemical impact of commercially available plant-derived nutritional supplements. An observational pilot-study on recreational athletes

    Directory of Open Access Journals (Sweden)

    Borrione Paolo

    2012-06-01

    Full Text Available Abstract Background A growing consumption of natural (plant-derived dietary supplements with ergogenic aims, with particular regard for ecdysteroids, phytoestrogens and vegetal sterols, has been registered over the last years among “recreational” athletes. The present study was carried out in order to evaluate the real knowledge of plant-derived nutritional supplements among physically active people as well as their real consumption. Additional aim was to evaluate the effects of these supplements on the health profile of the users. Methods Twenty-three trained subjects who habitually used natural dietary supplements, and 30 matched controls were analyzed for plasma biochemical markers and hormonal profile. Results The laboratory tests revealed the absence of any sign of organ toxicity/damage in both athletes and controls. On the contrary, hormone profiles revealed marked alterations in 15 (65% out of the 23 of investigated athletes. Specifically, 10 males presented increased plasma levels of progesterone, 15 subjects presented abnormal estrogen levels, including 5 (2 F and 3 M presenting a “dramatic” increased estrogen values and 2 two males with increased estrogen levels, increased testosterone levels and associated suppression of luteinizing hormone and follicle-stimulating hormone. Conclusions The results of the present study highlighted that the habitual consumption of plant-derived nutritional supplements is frequently associated with significant hormonal alterations both in male and female subjects. Although these biochemical alterations were not associated with signs or symptoms of organ toxicity/damage at the moment of the study, it cannot be excluded that, in the mid/long-term, these subjects would suffer of health problems secondary to chronic exposure to heavily altered hormonal levels. Further large scale studies are needed to confirm the results of this pilot study as well as to investigate the biological mechanisms at

  16. Israel Seminar 1989-90

    CERN Document Server

    Milman, Vitali

    1991-01-01

    The scope of the Israel seminar in geometric aspects of functional analysis during the academic year 89/90 was particularly wide covering topics as diverse as: Dynamical systems, Quantum chaos, Convex sets in Rn, Harmonic analysis and Banach space theory. The large majority of the papers are original research papers.

  17. Caltech-UCLA Logic Seminar

    CERN Document Server

    Martin, Donald; Steel, John

    1988-01-01

    This is the fourth volume of the proceeding of the Caltech-UCLA Logic Seminar, based mainly on material which was presented and discussed in the period 1981-85, but containing also some very recent results. It includes research papers dealing with determinacy hypotheses and their consequences in descriptive set theory. An appendix contains the new Victoria Delfino Problems.

  18. Music, Art, Drama, Civilization Seminar.

    Science.gov (United States)

    Hampton City School Board, VA.

    This 1-year elective seminar for high school students is to be taught in five units--Introduction, the Ancient World, the Medieval World, the Renaissance, and the Modern World--with emphasis on four basic themes expressed creatively throughout western history: (1) the common man, (2) the individual, (3) religion, and (4) conflict. Instruction on a…

  19. The 16th National Seminar on Crystallography: Abstract of papers

    Science.gov (United States)

    1982-03-01

    The abstracts of the papers received for this seminar are presented. These papers deal with the following subjects: Methods in Crystal Structure Analysis Including Computational Methods; Crystallography in Biology, Biohemistry, and Pharmacology; Atomic Scale Mechanisms, Physical Properties and Structures; Materials Science; Real and Ideal Crystals; Inorganic and Mineralogical Crystallography; Structures of Organic, Organic-Metallic Coordination Compounds and Polymers; Apparatus and Techniques; and Structural Methods Other Than Diffraction.

  20. Molecular and biochemical classification of plant-derived food allergens.

    Science.gov (United States)

    Breiteneder, H; Ebner, C

    2000-07-01

    Molecular biology and biochemical techniques have significantly advanced the knowledge of allergens derived from plant foods. Surprisingly, many of the known plant food allergens are homologous to pathogenesis-related proteins (PRs), proteins that are induced by pathogens, wounding, or certain environmental stresses. PRs have been classified into 14 families. Examples of allergens homologous to PRs include chitinases (PR-3 family) from avocado, banana, and chestnut; antifungal proteins such as the thaumatin-like proteins (PR-5) from cherry and apple; proteins homologous to the major birch pollen allergen Bet v 1 (PR-10) from vegetables and fruits; and lipid transfer proteins (PR-14) from fruits and cereals. Allergens other than PR homologs can be allotted to other well-known protein families such as inhibitors of alpha-amylases and trypsin from cereal seeds, profilins from fruits and vegetables, seed storage proteins from nuts and mustard seeds, and proteases from fruits. As more clinical data and structural information on allergenic molecules becomes available, we may finally be able to answer what characteristics of a molecule are responsible for its allergenicity.

  1. Technical Training seminar: Texas Instruments

    CERN Multimedia

    2006-01-01

    Monday 6 November TECHNICAL TRAINING SEMINAR 14:00 to 17:30 - Training Centre Auditorium (bldg. 593) Texas Instruments Technical Seminar Michael Scholtholt, Field Application Engineer / TEXAS INSTRUMENTS (US, D, CH) POWER - A short approach to Texas Instruments power products Voltage mode vs. current mode control Differentiating DC/DC converters by analyzing control and compensation schemes: line / load regulation, transient response, BOM, board space, ease-of-use Introduction to the SWIFT software FPGA + CPLD power solutions WIRELESS / CHIPCON Decision criteria when choosing a RF platform Introduction to Texas Instruments wireless products: standardized platforms proprietary platforms ( 2.4 GHz / sub 1 GHz) development tools Antenna design: example for 2.4 GHz questions, discussion Industrial partners: Robert Medioni, François Caloz / Spoerle Electronic, CH-1440 Montagny (VD), Switzerland Phone: +41 24 447 0137, email: RMedioni@spoerle.com, http://www.spoerle.com Language: English. Free s...

  2. Technical Training: Technical Training Seminar

    CERN Multimedia

    2004-01-01

    TECHNICAL TRAINING Monique Duval tel. 74924 technical.training@cern.ch Monday 9 February 2004 From 10:00 to 12:00 - IT Auditorium - bldg. 31, 3rd floor ANSOFT High-Frequency Seminar David Prestaux, Application Engineer, ANSOFT F-78535 BUC, France This Technical Training seminar will present two Ansoft application products: Ansoft HFSS and Ansoft Designer. Ansoft HFSS makes use of the Finite Element Method (FEM) to calculate field solutions from first principles. It can accurately predict all high-frequency behaviours such as dispersion, mode conversion, and losses due to materials and radiation. Ansoft Designer is a suite of design tools to fully integrate high-frequency, physics-based electromagnetic simulations into a seamless system-level simulation environment. Ansoft Designer uses a simple interface to give complete control over every design task, by a method allowing multiple solvers, Solver on Demand. • Introduction • Overview of the Ansoft Total solution • Ansoft HFSS 9...

  3. Intracellular reprogramming of expression, glycosylation, and function of a plant-derived antiviral therapeutic monoclonal antibody.

    Directory of Open Access Journals (Sweden)

    Jeong-Hwan Lee

    Full Text Available Plant genetic engineering, which has led to the production of plant-derived monoclonal antibodies (mAb(Ps, provides a safe and economically effective alternative to conventional antibody expression methods. In this study, the expression levels and biological properties of the anti-rabies virus mAb(P SO57 with or without an endoplasmic reticulum (ER-retention peptide signal (Lys-Asp-Glu-Leu; KDEL in transgenic tobacco plants (Nicotiana tabacum were analyzed. The expression levels of mAb(P SO57 with KDEL (mAb(PK were significantly higher than those of mAb(P SO57 without KDEL (mAb(P regardless of the transcription level. The Fc domains of both purified mAb(P and mAb(PK and hybridoma-derived mAb (mAb(H had similar levels of binding activity to the FcγRI receptor (CD64. The mAb(PK had glycan profiles of both oligomannose (OM type (91.7% and Golgi type (8.3%, whereas the mAb(P had mainly Golgi type glycans (96.8% similar to those seen with mAb(H. Confocal analysis showed that the mAb(PK was co-localized to ER-tracker signal and cellular areas surrounding the nucleus indicating accumulation of the mAb(P with KDEL in the ER. Both mAb(P and mAb(PK disappeared with similar trends to mAb(H in BALB/c mice. In addition, mAb(PK was as effective as mAb(H at neutralizing the activity of the rabies virus CVS-11. These results suggest that the ER localization of the recombinant mAb(P by KDEL reprograms OM glycosylation and enhances the production of the functional antivirus therapeutic antibody in the plant.

  4. In silico approach for the discovery of new PPARγ modulators among plant-derived polyphenols

    Directory of Open Access Journals (Sweden)

    Encinar JA

    2015-11-01

    Full Text Available José Antonio Encinar,1 Gregorio Fernández-Ballester,1 Vicente Galiano-Ibarra,2 Vicente Micol1,3 1Molecular and Cell Biology Institute, 2Physics and Computer Architecture Department, Miguel Hernández University, Elche, Spain; 3CIBER: CB12/03/30038 Physiopathology of Obesity and Nutrition, CIBERobn, Instituto de Salud Carlos III, Palma de Mallorca, SpainAbstract: Peroxisome proliferator-activated receptor gamma (PPARγ is a well-characterized member of the PPAR family that is predominantly expressed in adipose tissue and plays a significant role in lipid metabolism, adipogenesis, glucose homeostasis, and insulin sensitization. Full agonists of synthetic thiazolidinediones (TZDs have been therapeutically used in clinical practice to treat type 2 diabetes for many years. Although it can effectively lower blood glucose levels and improve insulin sensitivity, the administration of TZDs has been associated with severe side effects. Based on recent evidence obtained with plant-derived polyphenols, the present in silico study aimed at finding new selective human PPARγ (hPPARγ modulators that are able to improve glucose homeostasis with reduced side effects compared with TZDs. Docking experiments have been used to select compounds with strong binding affinity (ΔG values ranging from -10.0±0.9 to -11.4±0.9 kcal/mol by docking against the binding site of several X-ray structures of hPPARγ. These putative modulators present several molecular interactions with the binding site of the protein. Additionally, most of the selected compounds have favorable druggability and good ADMET properties. These results aim to pave the way for further bench-scale analysis for the discovery of new modulators of hPPARγ that do not induce any side effects. Keywords: virtual screening, molecular docking, high-throughput computing, TZDs, human PPARγ, AutoDock/Vina, ADMET, phenolic compounds

  5. Technical Training: Technical Training Seminar

    CERN Multimedia

    2004-01-01

    Tuesday 30 March TECHNICAL TRAINING SEMINAR From 9:00 to 12:00 and from 13:00 to 16:00 hrs - Council Chamber, Salle B, Salle des Pas Perdus National Instruments (NI) on Tour 2004 Claudia Jüngel, Evrem Yarkin, Joel Clerc, Hervé Baour / NATIONAL INSTRUMENTS The special event NI on Tour 2004, run in Germany, Austria and Switzerland, will be at CERN on March 30. Technical seminars and free introductory courses will be offered all day long in the Council Chamber, Salle B, and Salle des Pas Perdus (buildings 61 and 503). Technical conferences: 09:00 - 12:00 Data acquisition systems on PCs. Industrial measurement and control techniques. 13:00 - 16:00 Advanced LabVIEW software and PXI instrumentation. Measuring instruments and system components for teststand automation. Introductory courses: 09:00 - 12:00 DIAdem: Data analysis and presentation 13:00 - 16:00 Data acquisition with LabVIEW Language: English and French Free special seminar. Registration is recommended with National Instruments Swi...

  6. Technical Training: Technical Training Seminar

    CERN Multimedia

    2004-01-01

    Tuesday 30 March TECHNICAL TRAINING SEMINAR From 9:00 to 12:00 and from 13:00 to 16:00 hrs - Council Chamber, Salle B, Salle des Pas Perdus National Instruments (NI) on Tour 2004 Claudia Jüngel, Evrem Yarkin, Joel Clerc, Hervé Baour / NATIONAL INSTRUMENTS The special event NI on Tour 2004, run in Germany, Austria and Switzerland, will be at CERN on March 30. Technical seminars and free introductory courses will be offered all day long in the Council Chamber, Salle B, and Salle des Pas Perdus (buildings 61 and 503). Technical conferences: 09:00 - 12:00 Data acquisition systems on PCs. Industrial measurement and control techniques. 13:00 - 16:00 Advanced LabVIEW software and PXI instrumentation. Measuring instruments and system components for teststand automation. Introductory courses: 09:00 - 12:00 DIAdem: Data analysis and presentation 13:00 - 16:00 Data acquisition with LabVIEW Language: English and French Free special seminar. Registration is recommended with National Instruments Switzerland (please sp...

  7. Investigating genetic loci that encode plant-derived paleoclimate proxies

    Science.gov (United States)

    Bender, A. L. D.; Suess, M.; Chitwood, D. H.; Bradley, A. S.

    2016-12-01

    Long chain (>C25) n-alkanes in sediments predominantly derive from terrestrial plant waxes. Hydrogen isotope ratios (δD) of leaf wax hydrocarbons correlate with δDH2O of precipitation and are commonly used as paleoclimate proxies. However, biological variability in the isotopic fractionations between water and plant materials also affects the n-alkane δD values. Correct interpretation of this paleoclimate proxy requires that we resolve genetic and environmental effects. Genetic variability underlying differences in leaf wax structure and isotopic composition can be quantitatively determined through the use of model organisms. Interfertile Solanum sect. Lycopersicon (tomato) species provide an ideal model species complex for this approach. We used a set of 76 precisely defined near-isogenic lines (introgression lines [ILs]) in which small genomic regions from the wild tomato relative Solanum pennellii have been introduced into the genome of the domestic tomato, S. lycopersicum. By characterizing quantitative traits of these ILs (leaf wax structure and isotopic composition), we can resolve the degree to which each trait is regulated by genetic versus environmental factors. We present data from two growth experiments conducted with all 76 ILs. In this study, we quantify leaf wax traits, including δD values, δ13C values, and structural metrics including the methylation index (a variable that describes the ratio of iso­- and anteiso- to n-alkanes). Among ILs, δD values vary by up to 35‰ and 60‰ for C31 and C33 n-alkanes, respectively. Many ILs have methylation indices that are discernably different from the parent domesticated tomato (p < 0.001), which suggests that methylation is a highly polygenic trait. This pattern is similar to the genetics that control leaf shape, another trait commonly used as a paleoclimate proxy. Based on our preliminary analysis, we propose candidate genes that control aspects of plant physiology that affect these quantitative

  8. Oxidative Stress and Role of Natural Plant Derived Antioxidants in Animal Reproduction

    Institute of Scientific and Technical Information of China (English)

    ZHONG Rong-zhen; ZHOU Dao-wei

    2013-01-01

    The experimental knowledge on the role of oxidative stress, and beneifcial and detrimental effects of plant derived antioxidants in male and female animal reproduction are reviewed in this article. Free radical-induced oxidative stress in animal reproduction causes great loss to livestock industry. Antioxidant therapy has been implicated to be effective in preventing diseases resulted from oxidative stress. Considering the advantages of lower side effects of natural antioxidants than those of synthetic antioxidants, plants or their extracts have been extensively utilized in animals. Although many advances have been gained on application of plant derived antioxidants in alleviating oxidative stress, debatable issues still exist. Because many opposite effects were observed even using plant extracts containing similar bioactive substances in the same animal species. Therefore, plant derived antioxidants, like free radicals, are“double-edged swords”in animal reproduction, representing that they may exhibit beneifcial or detrimental effects in animal reproduction, including spermatogenesis, semen functions, estrous cycles, ovulation, ovary functions, endometrium, embryo development, and pregnancy. Besides dose-dependent manner as an explanation of plant extracts’ dual function, future studies are needed to investigate the mechanism of double-edged actions of plant derived antioxidants in different animal reproduction systems.

  9. USEPA SEMINARS ON INDOOR AIR VAPOR INTRUSION

    Science.gov (United States)

    This interactive CD has been developed to introduce you to the seminar speakers and their presentation topics. It includes introduction and overview video clips, an interactive class exercise that explains how to interpret and use the new EPA IAVI Guidance, a scrolling seminar vi...

  10. A Seminar On Shanghai Airport Airspace Held

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    <正>A seminar on Shanghai airport airspace, sponsored by the airport’s second-phase project headquarters and East China Air Traffic Administration, was held in Shanghai between March 21 and 23.Present at the seminar were Shanghai Vice-Mayor

  11. China-Spain Urban Transport Seminar

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    <正>The China-Spain Seminar on Urban Transport jointly sponsored by the Chinese Committee of the China-Spain Forum and the Agency of International Cooperation of the Spanish Foreign Ministry was held in Beijing from May 10 to 14, 2004. The Seminar was

  12. 33. MPA seminar 2007. Proceedings; 33. MPA Seminar 2007. Vortraege

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    In a single PDF file, the CD-ROM contains all papers presented at the 33. MPA Seminar in Stuttgart. Subjects: Life management of nuclear facilities: Materials, integrity analysis, fracture mechanics; Behaviour of welds; Material development and qualification for power plants with enhanced steam parameters; monitoring concepts (e.g. state monitoring of components, test concepts); Design of pipelines with flanged joints; Assembly and joining technology for flanged joints; Non-destructive testing in plant engineering; Materials for new nuclear reactors. Many of the papers are available as separate items in this database. [German] In einer einzigen PDF-Datei sind auf der CD-ROM alle Vortraege enthalten, die auf dem 33. MPA-Seminar in Stuttgart gehalten wurden. Die Themenschwerpunkte sind: Lebensdauermanagement kerntechnischer Anlagen - Werkstoffverhalten, Integritaetsanalyse, Bruchmechanik; Verhalten von Schweissverbindungen; Werkstoffentwicklung und -qualifizierung fuer Kraftwerke mit erhoehten Dampfparametern; Ueberwachungskonzepte (z.B. Zustandsueberwachung von Komponenten, Pruefkonzepte); Auslegung von Rohrleitungen mit Flanschverbindungen; Montage- und Dichtungstechnik fuer Flanschverbindungen; Zerstoerungsfreie Pruefung in der Anlagentechnik; Werkstoffe fuer neue Kernreaktoren. Ein grosser Teil der Vortraege wurde separat aufgenommen.

  13. A seminar on graph theory

    CERN Document Server

    Harary, Frank

    2015-01-01

    Presented in 1962-63 by experts at University College, London, these lectures offer a variety of perspectives on graph theory. Although the opening chapters form a coherent body of graph theoretic concepts, this volume is not a text on the subject but rather an introduction to the extensive literature of graph theory. The seminar's topics are geared toward advanced undergraduate students of mathematics.Lectures by this volume's editor, Frank Harary, include ""Some Theorems and Concepts of Graph Theory,"" ""Topological Concepts in Graph Theory,"" ""Graphical Reconstruction,"" and other introduc

  14. Israel Seminar 1996–2000

    CERN Document Server

    Schechtman, Gideon

    2000-01-01

    This volume of original research papers from the Israeli GAFA seminar during the years 1996-2000 not only reports on more traditional directions of Geometric Functional Analysis, but also reflects on some of the recent new trends in Banach Space Theory and related topics. These include the tighter connection with convexity and the resulting added emphasis on convex bodies that are not necessarily centrally symmetric, and the treatment of bodies which have only very weak convex-like structure. Another topic represented here is the use of new probabilistic tools; in particular transportation of measure methods and new inequalities emerging from Poincaré-like inequalities.

  15. 34th Atlanta Executive Seminar

    Science.gov (United States)

    2009-04-23

    Seminar “Supporting the Warfighter in an Era of New Challenges” Atlanta, Georgia 21 - 23 April 2009 Wednesday, April 22, 2009 “A Wall Street ...60L, Blackhawk Colombia : 15 - UH-60L, Blackhawks 360 - Assorted small arms (Numerous Cases) 39 – Armored Security Vehicles 214 - NVDs Chile: Avenger...the Chain  The Good News: Sellers and Buyers Will Be Motivated to Consolidate ($USD, Millions) DoD FY06 DoD FY07 DoD FY08E DoD FY09E Procurment

  16. Israel Seminar 2001-2002

    CERN Document Server

    Schechtman, Gideon

    2003-01-01

    The proceedings of the Israeli GAFA seminar on Geometric Aspect of Functional Analysis during the years 2001-2002 follow the long tradition of the previous volumes. They continue to reflect the general trends of the Theory. Several papers deal with the slicing problem and its relatives. Some deal with the concentration phenomenon and related topics. In many of the papers there is a deep interplay between Probability and Convexity. The volume contains also a profound study on approximating convex sets by randomly chosen polytopes and its relation to floating bodies, an important subject in Classical Convexity Theory. All the papers of this collection are original research papers.

  17. Short communication: an in vitro assessment of the antibacterial activity of plant-derived oils.

    Science.gov (United States)

    Mullen, K A E; Lee, A R; Lyman, R L; Mason, S E; Washburn, S P; Anderson, K L

    2014-09-01

    Nonantibiotic treatments for mastitis are needed in organic dairy herds. Plant-derived oils may be useful but efficacy and potential mechanisms of action of such oils in mastitis therapy have not been well documented. The objective of the current study was to evaluate the antibacterial activity of the plant-derived oil components of Phyto-Mast (Bovinity Health LLC, Narvon, PA), an herbal intramammary product, against 3 mastitis-causing pathogens: Staphylococcus aureus, Staphylococcus chromogenes, and Streptococcus uberis. Plant-derived oils evaluated were Thymus vulgaris (thyme), Gaultheria procumbens (wintergreen), Glycyrrhiza uralensis (Chinese licorice), Angelica sinensis, and Angelica dahurica. Broth dilution testing according to standard protocol was performed using ultrapasteurized whole milk instead of broth. Controls included milk only (negative control), milk + bacteria (positive control), and milk + bacteria + penicillin-streptomycin (antibiotic control, at 1 and 5% concentrations). Essential oil of thyme was tested by itself and not in combination with other oils because of its known antibacterial activity. The other plant-derived oils were tested alone and in combination for a total of 15 treatments, each replicated 3 times and tested at 0.5, 1, 2, and 4% to simulate concentrations potentially achievable in the milk within the pre-dry-off udder quarter. Thyme oil at concentrations ≥2% completely inhibited bacterial growth in all replications. Other plant-derived oils tested alone or in various combinations were not consistently antibacterial and did not show typical dose-response effects. Only thyme essential oil had consistent antibacterial activity against the 3 mastitis-causing organisms tested in vitro. Further evaluation of physiological effects of thyme oil in various preparations on mammary tissue is recommended to determine potential suitability for mastitis therapy. Copyright © 2014 American Dairy Science Association. Published by Elsevier

  18. Plant derived antioxidants and antifibrotic drugs:past, present and future

    Institute of Scientific and Technical Information of China (English)

    Devaraj Ezhilarasan; Etienne Sokal; Sivanesan Karthikeyan; Mustapha Najimi

    2014-01-01

    Hepatic fibrosis occurs as a wound-healing process after several forms of chronic hepatic injury. Activation and proliferation of hepatic stellate cells play pivotal role in the pathogenesis of hepatic fibrosis. Many researchers, from the therapeutic perspective, have focused their attention on searching for novel agents with inhibitory effects on hepatic stellate cells proliferation and activation to prevent hepatic fibrogenesis and a number of plant derived antioxidants have been tested as anti-fibrogenic agents, they generally suppress proliferation and collagen synthesis. Plants remain an imperative source of novel drugs, novel drug leads and new chemical entities. The plant based drug discovery resulted primarily in the development of antioxidant, anti-cancer and other anti-infectious agents and continues to contribute to the new leads in clinical trials. This review summarizes some of those most important plant derived anti-fibrotic drugs and their beneficial effects on experimentally induced hepatic fibrosis in vitro and in vivo. The plant derived antioxidant compounds described herein are curcumin, silymarin, silibinin, baicalein, resveratrol, salvianolic acids, tetrandine, quercetin and berberine. Studies from ours and as demonstrated by pervious workers much information has been accumulated over the past two decades through in vivo and in vitro. In light of those studies, it has been confirmed that plants derived antioxidants, particularly flavanoids, show a significant influence to block hepatic fibrosis regardless of any etiology. This review outlines recent progress in the use of plant derived drugs against experimentally induced liver fibrosis by in vitro and in vivo studies and summarizes the possible mechanisms anti-fibrotic effects of these compounds.

  19. Geneva University - Particle Physics Seminars

    CERN Multimedia

    Université de Genève

    2010-01-01

    GENEVA UNIVERSITY École de physique Département de physique nucléaire et corspusculaire 24, quai Ernest-Ansermet 1211 GENÈVE 4 Tél. (022) 379 62 73 Fax: (022) 379 69 92 Wednesday 13 October 2010 PARTICLE PHYSICS SEMINAR at 17.00 hrs – Stückelberg Auditorium Exotic hadrons, Light Higgs and Dark Forces at BABAR Dr. Bertrand Echenard / California Institute of Technology From spectroscopy to search new physics, B-factories have explored many exciting topics besides establishing CP-violation in B decays. We will review recent results on spectroscopy, exotic hadrons and search for light Higgs. Current searches for dark forces and GeV-scale dark matter particles will also be discussed. Information : http://dpnc.unige.ch/seminaire/annonce.html Organizer : G. Pasztor Wednesday 20 October 2010 PARTICLE PHYSICS SEMINAR at 17.00 hrs – Stückelberg Auditorium The MINOS Experiment, Results and Future Plans Pro...

  20. PREPARATION FOR RETIREMENT - AVS SEMINAR

    CERN Multimedia

    Social Service

    2001-01-01

    The 500 or so participants in the fifth Preparation for Retirement seminar held at the end of March were unfortunately deprived of the planned session on the AVS due to the unavailability of the Director of the Caisse Cantonale Genevoise de Compensation (CCGC). We have since had formal confirmation that because of an extra workload due to important changes in the Swiss tax and social legislation and the implementation this summer of the maternity insurance in Geneva, the CCGC has suspended its participation in preparation for retirement seminars in the international organisations for the time being. Conscious of the necessity of offering a session dedicated to the AVS, it is with pleasure that we can inform you that one of our legal advisers, Mr Lorenz Stampfli, has accepted to lead this session. In order to allow for adequate preparation we have reserved the following date: Wednesday 26 September from 14.00 to 16.00 in the Main Amphitheatre The session will be open to all people already registered and any o...

  1. TECHNICAL TRAINING SEMINAR: National Instruments

    CERN Multimedia

    Monique Duval

    2004-01-01

    From 9:30 to 12:00 and from 13:00 to 16:00 hrs - Council Chamber, Salle B, Salle des Pas Perdus National Instruments (NI) on Tour 2004 Claudia Jüngel, Evrem Yarkin, Joel Clerc, Hervé Baour / NATIONAL INSTRUMENTS The special event NI on Tour 2004, run in Germany, Austria and Switzerland, will be at CERN on March 30. Technical seminars and free introductory courses will be offered all day long in the Council Chamber, Salle B, and Salle des Pas Perdus (buildings 61 and 503). Data acquisition systems on PCs, industrial measurement and control techniques, advanced LabVIEW software and PXI instrumentation, and system components for tests and automation will be presented. Walk-in courses will address DIAdem, LabVIEW and data acquisition. Language: English and French Free seminars and courses, no registration Organisers: Rolf Stampfli / IT-CO / 78102 & 160367 / Rolf.Stampfli@cern.ch Davide Vitè / HR-PMD-ATT / 75141 Davide.Vite@cern.ch For more information and the complete event programme, please visit the...

  2. Seminar on Egypt population policy.

    Science.gov (United States)

    Kantner, J F

    1984-01-01

    The information and viewpoints presented at the Seminar on Egypt Population Policy held in Cairo on October 16-18 were summariezed and critically assessed. The seminar was organized by the International Union for the Scientific Study of Population's Committee on the Utilization ofDemographic Knowlege in Policy Formulation and Planning for the purpose of assessing the policy making the utility of social science and demographc knowledge with specific reference to Egypt's family planning program. The seminar was attended by demographers, social scientists, and experienced policy makers, and the discussion was highly focused. Seminar papers and discussions sought to clarify Egypt's current demographic situation, attempted to use sample survey data to identifyfertility determinants, analyzed Egypt's policyresponses to the population problem, assessed the national family planning program, identified the type of knowledge available for policy making, and noted areas where policy relevant information is lacking. Evidence presented at the seminar indicated that Egyptian fertility is still high and that corrected the total fertility rate for 1980 was close to 6. Since, 1960, fertility declined in all regions of the country, but between 1976-80 the decline decelerated. This deceleration appears to be a temporary phenonemon. There is evidence that the age at marriage is increasing, that the population is motivated to use contraception when desired family size is reached, that contraceptive use is cost sensitive, and that the overall decline in fertility since the 1960s occurred in all parts of the country. Papers which presented analyses of fertility determinants, based on sample survey data, provided little useful insight for policy formulation. The studies indicate that the impact of family planning services on different segments of the population varies, and that these impacts may be increased if social and economic development persists. The preception of the population

  3. Increasing Effectiveness of Strategic Planning Seminars through Learning Style

    Science.gov (United States)

    Yildirim, Nail

    2010-01-01

    This research tests the effectiveness of taking learning style variables from the Kolb learning model in designing strategic planning seminars. We observe in our research that the participants in the seminar--school principals--positively judge the effectiveness of the seminar. The research also tests the seminar's effectiveness in terms of the…

  4. Senior Seminar: Across a Department and across The Years

    Science.gov (United States)

    Greer, Meredith L.; Ross, Chip

    2013-01-01

    The Department of Mathematics at Bates College has offered a senior seminar capstone course for over a dozen years. In this article, we discuss the coexistence of seminar and thesis, our other capstone experience. We discuss in detail the goals of our seminar, various ways we structure the seminar to accomplish those goals, and methods of…

  5. Seminar

    African Journals Online (AJOL)

    abp

    6 mai 2014 ... presentation of lobular, ductal, mixed and special typa breast cancer. ... with hormone replacement therapy: implications for diagnosis, surgical and medical treatment. Endocr Relat Cancer. 2007 ... Sensitivity of MRI versus.

  6. Proceedings of the fifth NUCEF seminar

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-12-01

    The Fifth NUCEF Seminar was held at Tokai Research Establishment, JAERI on February 27, 2001. The NUCEF Seminar aims at the promotion of effective researches and encouragement of research cooperation through the discussions and information exchanges by researchers in the field of the nuclear fuel cycle back-end. This seminar was divided into the following sessions: TRU Chemistry, Radioactive Waste Management, Criticality Safety and Partitioning/Reprocessing. At the panel discussion, important issues connected with the safety research for radioactive waste management were discussed among five speakers from the relevant organization in Japan. The 36 of the presented papers are indexed individually. (J.P.N.)

  7. Combating Pathogenic Microorganisms Using Plant-Derived Antimicrobials: A Minireview of the Mechanistic Basis

    Directory of Open Access Journals (Sweden)

    Abhinav Upadhyay

    2014-01-01

    Full Text Available The emergence of antibiotic resistance in pathogenic bacteria has led to renewed interest in exploring the potential of plant-derived antimicrobials (PDAs as an alternative therapeutic strategy to combat microbial infections. Historically, plant extracts have been used as a safe, effective, and natural remedy for ailments and diseases in traditional medicine. Extensive research in the last two decades has identified a plethora of PDAs with a wide spectrum of activity against a variety of fungal and bacterial pathogens causing infections in humans and animals. Active components of many plant extracts have been characterized and are commercially available; however, research delineating the mechanistic basis of their antimicrobial action is scanty. This review highlights the potential of various plant-derived compounds to control pathogenic bacteria, especially the diverse effects exerted by plant compounds on various virulence factors that are critical for pathogenicity inside the host. In addition, the potential effect of PDAs on gut microbiota is discussed.

  8. Israel Seminar 2004-2005

    CERN Document Server

    Schechtman, Gideon

    2007-01-01

    This collection of original papers related to the Israeli GAFA seminar (on Geometric Aspects of Functional Analysis) during the years 2004-2005 follows the long tradition of the previous volumes that reflect the general trends of the Theory and are a source of inspiration for research. Most of the papers deal with different aspects of the Asymptotic Geometric Analysis, ranging from classical topics in the geometry of convex bodies, to inequalities involving volumes of such bodies or, more generally, log-concave measures, to the study of sections or projections of convex bodies. In many of the papers Probability Theory plays an important role; in some limit laws for measures associated with convex bodies, resembling Central Limit Theorems, are derive and in others probabilistic tools are used extensively. There are also papers on related subjects, including a survey on the behavior of the largest eigenvalue of random matrices and some topics in Number Theory.

  9. Israel Seminar 2006–2010

    CERN Document Server

    Mendelson, Shahar; Milman, Vitali

    2012-01-01

    This collection of original papers related to the Israeli GAFA seminar (on Geometric Aspects of Functional Analysis) from the years 2006 to 2011 continues the long tradition of the previous volumes, which reflect the general trends of Asymptotic Geometric Analysis, understood in a broad sense, and are a source of inspiration for new research. Most of the papers deal with various aspects of the theory, including classical topics in the geometry of convex bodies, inequalities involving volumes of such bodies or more generally, logarithmically-concave measures, valuation theory, probabilistic and isoperimetric problems in the combinatorial setting, volume distribution on high-dimensional spaces and characterization of classical constructions in Geometry and Analysis (like the Legendre and Fourier transforms, derivation and others). All the papers here are original research papers.

  10. Israel Seminar 2011-2013

    CERN Document Server

    Milman, Emanuel

    2014-01-01

    As in the previous Seminar Notes, the current volume reflects general trends in the study of Geometric Aspects of Functional Analysis. Most of the papers deal with different aspects of Asymptotic Geometric Analysis, understood in a broad sense; many continue the study of geometric and volumetric properties of convex bodies and log-concave measures in high-dimensions and in particular the mean-norm, mean-width, metric entropy, spectral-gap, thin-shell and slicing parameters, with applications to Dvoretzky and Central-Limit-type results. The study of spectral properties of various systems, matrices, operators and potentials is another central theme in this volume. As expected, probabilistic tools play a significant role and probabilistic questions regarding Gaussian noise stability, the Gaussian Free Field and First Passage Percolation are also addressed. The historical connection to the field of Classical Convexity is also well represented with new properties and applications of mixed-volumes. The interplay be...

  11. Israel Seminar 2014-2016

    CERN Document Server

    Milman, Emanuel

    2017-01-01

    As in the previous Seminar Notes, the current volume reflects general trends in the study of Geometric Aspects of Functional Analysis, understood in a broad sense. A classical theme in the Local Theory of Banach Spaces which is well represented in this volume is the identification of lower-dimensional structures in high-dimensional objects. More recent applications of high-dimensionality are manifested by contributions in Random Matrix Theory, Concentration of Measure and Empirical Processes. Naturally, the Gaussian measure plays a central role in many of these topics, and is also studied in this volume; in particular, the recent breakthrough proof of the Gaussian Correlation Conjecture is revisited. The interplay of the theory with Harmonic and Spectral Analysis is also well apparent in several contributions. The classical relation to both the primal and dual Brunn-Minkowski theories is also well represented, and related algebraic structures pertaining to valuations and valent functions are discussed. All co...

  12. Aligning seminars with Bologna requirements

    DEFF Research Database (Denmark)

    Lueg, Klarissa; Lueg, Rainer; Lauridsen, Ole

    2016-01-01

    Changes in public policy, such as the Bologna Process, require students to be equipped with multifunctional competencies to master relevant tasks in unfamiliar situations. Achieving this goal might imply a change in many curricula toward deeper learning. As a didactical means to achieve deep...... learning results, the authors suggest reciprocal peer tutoring (RPT); as a conceptual framework the authors suggest the SOLO (Structure of Observed Learning Outcomes) taxonomy and constructive alignment as suggested by Biggs and Tang. Our study presents results from the introduction of RPT in a large...... course. The authors find that RPT produces satisfying learning outcomes, active students, and ideal constructive alignments of the seminar content with the exam, the intended learning outcomes, and the requirements of the Bologna Process. Our data, which comprise surveys and evaluations from both faculty...

  13. Novel Plant-Derived Recombinant Human Interferons with Broad Spectrum Antiviral Activity

    Science.gov (United States)

    2011-10-14

    compared the antiviral activities of more than 1400 plant-derived, hybrid IFNs against three RNA viruses and one DNA virus from four different families...highly pathogenic viruses with varying sensitivities to type I IFN. In particular, the DNA virus , MPXV, was not expected to be as susceptible to the...K.M., Callis, R.T., Stephen, E.L., 1980. Lassa virus infection of rhesus monkeys: pathogenesis and treatment with ribavirin. J. Infect. Dis. 141, 580

  14. Antioxidant Capacity Determination in Plants and Plant-Derived Products: A Review

    OpenAIRE

    2016-01-01

    The present paper aims at reviewing and commenting on the analytical methods applied to antioxidant and antioxidant capacity assessment in plant-derived products. Aspects related to oxidative stress, reactive oxidative species’ influence on key biomolecules, and antioxidant benefits and modalities of action are discussed. Also, the oxidant-antioxidant balance is critically discussed. The conventional and nonconventional extraction procedures applied prior to analysis are also presented, as th...

  15. Alleviation of Boron Stress through Plant Derived Smoke Extracts in Sorghum bicolor

    Directory of Open Access Journals (Sweden)

    Pirzada Khan

    2014-08-01

    Full Text Available Boron is an essential micronutrient necessary for plant growth at optimum concentration. However, at high concentrations boron affects plant growth and is toxic to cells. Aqueous extract of plant-derived smoke has been used as a growth regulator for the last two decades to improve seed germination and seedling vigor. It has been established that plant-derived smoke possesses some compounds that act like plant growth hormones. The present research was the first comprehensive attempt to investigate the alleviation of boron stress with plant-derived smoke aqueous extract on Sorghum (Sorghum bicolor seed. Smoke extracts of five plants, i.e. Cymbopogon jwarancusa, Eucalyptus camaldulensis, Peganum harmala, Datura alba and Melia azedarach each with six dilutions (Concentrated, 1:100, 1:200, 1:300, 1:400 and 1:500 were used. While boron solutions at concentrations of 5, 10, 15, 20 and 25 ppm were used for stress. Among the dilutions of smoke, 1:500 of E. camaldulensis significantly increased germination percentage, root and shoot length, number of secondary roots and fresh weight of root and shoot while, boron stress reduced growth of Sorghum. It was observed that combined effect of boron solution and E. camaldulensis smoke extract overcome inhibition and significantly improved plant growth. Present research work investigated that the smoke solution has the potential to alleviate boron toxicity by reducing the uptake of boron by maintaining integrity of plant cell wall. The present investigation suggested that plant derived smoke has the potential to alleviate boron stress and can be used to overcome yield losses caused by boron stress to plants.

  16. 2007 Plant Metabolic Engineering Gordon Conference and Graduate Research Seminar

    Energy Technology Data Exchange (ETDEWEB)

    Erich Grotewold

    2008-09-15

    Plant Metabolic Engineering is an emerging field that integrates a diverse range of disciplines including plant genetics, genomics, biochemistry, chemistry and cell biology. The Gordon-Kenan Graduate Research Seminar (GRS) in Plant Metabolic Engineering was initiated to provide a unique opportunity for future researcher leaders to present their work in this field. It also creates an environment allowing for peer-review and critical assessment of work without the intimidation usually associated with the presence of senior investigators. The GRS immediately precedes the Plant Metabolic Engineering Gordon Research Conference and will be for and by graduate students and post-docs, with the assistance of the organizers listed.

  17. IFLA pimedate raamatukogude sektsiooni seminar / Marja Kivihall

    Index Scriptorium Estoniae

    Kivihall, Marja, 1975-

    2008-01-01

    27.-28. veebruaril 2008 toimus Horvaatia pealinnas Zagrebis IFLA pimedate raamatukogude sektsiooni ja DAISY Konsortsiumi seminar "Putting libraries for the blind and print disabled on the agenda", kus artikli autor Marja Kivihall esines ettekandega Eesti Pimedate Raamatukogust

  18. Muuseumiprofessionaalide seminar / Ülle Kruus

    Index Scriptorium Estoniae

    Kruus, Ülle

    2003-01-01

    5. II toimus Briti Nõukogu korraldusel Helsingis muuseumi suhetele avalikkusega suunatud seminar "The Public Face of museums". Eestist osalesid Peeter Mauer, Jaanus Plaat, Merike Lang, Tiia Toomet, Agne Trummal, Ülle Kruus

  19. Italian Textile Machinery Seminar in Bangladesh

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    The Association of Italian Textile Machinery Manufacturers (ACIMIT) and the Italian Trade Commission will hold a technological seminar on "Italian textile machinery: the way to improve Bangladesh textile competitiveness"

  20. IFLA pimedate raamatukogude sektsiooni seminar / Marja Kivihall

    Index Scriptorium Estoniae

    Kivihall, Marja, 1975-

    2008-01-01

    27.-28. veebruaril 2008 toimus Horvaatia pealinnas Zagrebis IFLA pimedate raamatukogude sektsiooni ja DAISY Konsortsiumi seminar "Putting libraries for the blind and print disabled on the agenda", kus artikli autor Marja Kivihall esines ettekandega Eesti Pimedate Raamatukogust

  1. Visits Service Launches New Seminar Series

    CERN Multimedia

    2001-01-01

    The CERN Visits Service is launching a new series of seminars for guides, and they are open to everyone. The series kicks off next week with a talk by Konrad Elsener on the CERN neutrinos to Gran Sasso, CNGS, project.

  2. 2015 Cross-Domain Deterrence Seminar Bibliography

    Energy Technology Data Exchange (ETDEWEB)

    Juarez, Anthony [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2016-02-04

    In November 2015, the Center for Global Security Research, NSO, and Global Security program jointly sponsored a seminar investigating questions related to cross-domain deterrence at Lawrence Livermore National Laboratory. At the seminar, experts were asked to moderate discussion based on the four topics below. For each of these topics, we have compiled a short list of literature that will help analysts develop a baseline understanding of the issue.

  3. Distributed Cloud Computing (Dagstuhl Seminar 15072)

    OpenAIRE

    Coady, Yvonne; Kempf, James; McGeer, Rick; Schmid, Stefan

    2015-01-01

    This report documents the program and the outcomes of Dagstuhl Seminar 15072 "Distributed Cloud Computing". A distributed cloud connecting multiple, geographically distributed and smaller datacenters, can be an attractive alternative to today's massive, centralized datacenters. A distributed cloud can reduce communication overheads, costs, and latency's by offering nearby computation and storage resources. Better data locality can also improve privacy. In this seminar, we revisit the vision o...

  4. Fourth Sino-British Local Government Seminar

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    <正>The 4th Sino-British Local Government Seminar jointly sponsored by the CPAFFC, the China International Friendship Cities Association, the China-EU Association and the Local Government International Bureau of the UK (LGIB) was held in Beijing on June 29, 2004. He Luli, vice-chairperson of the Standing Committee of the National People’s Congress, attended the seminar and delivered a speech. CPAFFC President Chen Haosu made a keynote speech. Ken Bodfish,

  5. Experimental Seminar on Nuclear Energy for Teachers

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-02-01

    `Experimental Seminar on Nuclear Energy for Teachers` was conducted and sponsored by the Science and Technology Agency. And in order to understand nuclear energy properly through lectures and experiments with good results inclass, the seminar carried out for teachers of high schools and junior high schools by the Nuclear Technology and Education Center (NuTEC), Japan Atomic Energy Research Institute in 1990 FY to 1997 FY. In this report, details of the seminars in the above period are described and No.1 to 17 of Communication Letters of Experimental Seminar on Nuclear Energy` started at 1992 FY are described also. These letters were prepared for attendant follow-up program. And programs of recent seminars, future`s seminars, impressions and comments from attendants, reports from actual classes and others are described in these letters and they are very useful for educational classes on nuclear energy by other teachers. Therefore contents of the letters are listed and easy to refer. A part of this educational task was transferred to the Radiation Application Development Association in 1997 FY and other parts were transferred in 1998 FY. (author)

  6. Yeast surface display is a novel tool for the rapid immunological characterization of plant-derived food allergens.

    Science.gov (United States)

    Popovic, Milica; Prodanovic, Radivoje; Ostafe, Raluca; Schillberg, Stefan; Fischer, Rainer; Gavrovic-Jankulovic, Marija

    2015-03-01

    High-throughput characterization of allergens relies often on phage display technique which is subject to the limitations of a prokaryotic expression system. Substituting the phage display platform with a yeast surface display could lead to fast immunological characterization of allergens with complex structures. Our objective was to evaluate the potential of yeast surface display for characterization of plant-derived food allergens. The coding sequence of mature actinidin (Act d 1) was cloned into pCTCON2 surface display vector. Flow cytometry was used to confirm localization of recombinant Act d 1 on the surface of yeast cells using rabbit polyclonal antisera IgG and IgE from sera of kiwifruit-allergic individuals. Immunological (dot blot, immunoblot ELISA and ELISA inhibition), biochemical (enzymatic activity in gel) and biological (basophil activation) characterization of Act d 1 after solubilization from the yeast cell confirmed that recombinant Act d 1 produced on the surface of yeast cell is similar to its natural counterpart isolated from green kiwifruit. Yeast surface display is a potent technique that enables fast immunochemical characterization of allergens in situ without the need for protein purification and offers an alternative that could lead to improvement of standard immunodiagnostic and immunotherapeutic approaches.

  7. Technical Training: Technical Training Seminar

    CERN Multimedia

    2004-01-01

    TECHNICAL TRAINING Monique Duval tel. 74924 technical.training@cern.ch Tuesday 3 February 2004 From 09:00 to 13:30 - Training Centre Auditorium - bldg. 593, room 11 USB (Universal Serial Bus) CYPRESS Seminar Claudia Colombini, Field Application Engineer CYPRESS ActiveComp Electronic GmbH D-85077 MANCHING, Germany As a pioneer in USB, CYPRESS sets the standard for cost-effective solutions without sacrificing functionality, performance or reliability. Having shipped over 200 million USB devices, Cypress is the undisputed market leader and demonstrates unmatched USB expertise. With the industry's broadest selection of USB solutions, Cypress has the right silicon, software and support for every USB application, from Low-speed to High-Speed and USB On-The-Go (OTG). 9:00 - 10:30 Overview of USB systems. USB CYPRESS product overview. Peripherals: Low Speed, Full Speed, High Speed (1.1 and 2.0). Hub Solutions, Embedded Host Solutions, On-The-Go (OTG) and wireless USB. USB Development Tools (first part) 10:30 -...

  8. Geneva University - Particle Physics seminar

    CERN Multimedia

    Université de Genève

    2011-01-01

    UNIVERSITE DE GENEVE Ecole de physique Département de physique nucléaire et corspusculaire 24, quai Ernest-Ansermet 1211 Geneva 4 Tel. (022) 379 62 73 Fax (022) 379 69 92 Wednesday 8 June 2011 PARTICLE PHYSICS SEMINAR at 17.00 hrs – Stückelberg Auditorium A Novel Experiment for the Search muon -> eee Prof. Andre Schoening, University of Heidelberg The absence of lepton-flavor changing processes, like the non-observation of the radiative decay mu -> e gamma, has been a miracle since the dawn of the Standard Model of Particle Physics and lead to the introduction of the concept of lepton family numbers. Several experiments in the last decade have shown clear evidence for neutrino oscillations. The neutrino mixing angles measured are known to be large. However, the discovery of lepton flavor violating (LFV) effects in the charged lepton sector is yet owing. After motivating the search for LFV in general I will discuss the physics potential of a search m...

  9. Safety assessment of animal- and plant-derived amino acids as used in cosmetics.

    Science.gov (United States)

    Burnett, Christina; Heldreth, Bart; Bergfeld, Wilma F; Belsito, Donald V; Hill, Ronald A; Klaassen, Curtis D; Liebler, Daniel C; Marks, James G; Shank, Ronald C; Slaga, Thomas J; Snyder, Paul W; Andersen, F Alan

    2014-01-01

    The Cosmetic Ingredient Review Expert Panel (Panel) reviewed the safety of animal- and plant-derived amino acid mixtures, which function as skin and hair conditioning agents. The safety of α-amino acids as direct food additives has been well established, based on extensive research through acute and chronic dietary exposures and the Panel previously has reviewed the safety of individual α-amino acids in cosmetics. The Panel focused its review on dermal irritation and sensitization data relevant to the use of these ingredients in topical cosmetics. The Panel concluded that these 21 ingredients are safe in the present practices of use and concentration as used in cosmetics.

  10. Soil chemical properties as affected by plant derived ash to replace potassium fertilizer and its conversion value

    Directory of Open Access Journals (Sweden)

    John Bako Baon

    2011-08-01

    Full Text Available Potassium chloride (KCl presently used as main source of K, tends to become more expensive, therefore, there is a need for a breakthrough in finding alternative materials to replace KCl. The aim of this paper is to present recent research on the use of plant derived ash to replace KCl fertilizer, especially in relation with soil chemical characteristics and its conversion value. Plant derived ash coming from palm sugar processing unit which use farm waste as main fuel was used in this experiment. Treatments investigated were no K2O application (control, applied with K2O in forms of both KCl and plant derived ash in dosages of 100, 200, 300, 400, 500 and 600 mg kg-1 air dry soil. The mixture of soil with those treatments were then incubated for one year. After incubation period, the soil in pots were divided into two parts, first part was added with 2g urea, while other part was added with 2 g SP 36. Both parts were incubated for two months. Results of this experiment showed that plant derived ash can be used to replaced KCl. To obtain similar soil K content, the amount of K2O in form of plant derived ash needed to be added or its conversion value is 1.44 times the amount of K2O in form of KCl. Use of plant derived ash also increased the content of soil Ca, available P, ratio of Ca/Mg and pH. Plant derived ash did not caused nitrogen loss. Key words: Potassium, fertilizer, plant derived ash, pH, soil.

  11. Freshman Seminars: Interdisciplinary Engagements in Astronomy

    Science.gov (United States)

    Hemenway, M. K.

    2006-08-01

    The Freshman Seminar program at the University of Texas is designed to allow groups of fifteen students an engaging introduction to the University. The seminars introduce students to the resources of the university and allow them to identify interesting subjects for further research or future careers. An emphasis on oral and written communication by the students provides these first-year students a transition to college-level writing and thinking. Seminar activities include field trips to an art museum, a research library, and the Humanities Research Center rare book collection. This paper will report on two seminars, each fifteen weeks in length. In "The Galileo Scandal" students examine Galileo's struggle with the church (including a mock trial). They perform activities that connect his use of the telescope and observations to astronomical concepts. In "Astronomy and the Humanities" students analyze various forms of human expression that have astronomical connections (art, drama, literature, music, poetry, and science fiction); they perform hands-on activities to reinforce the related astronomy concepts. Evaluation of the seminars indicates student engagement and improvement in communication skills. Many of the activities could be used independently to engage students enrolled in standard introductory astronomy classes.

  12. 19th International Seminar on High Energy Physics

    CERN Document Server

    2016-01-01

    "Quarks-2016" is the nineteenth in the series of seminars taking place biennially since 1980 in the Soviet Union and since 1992 in various historical and cultural places of Russia; the previous seminar, "Quarks-2014", was held in Suzdal.

  13. Plant-Derived Polyphenols Interact with Staphylococcal Enterotoxin A and Inhibit Toxin Activity.

    Directory of Open Access Journals (Sweden)

    Yuko Shimamura

    Full Text Available This study was performed to investigate the inhibitory effects of 16 different plant-derived polyphenols on the toxicity of staphylococcal enterotoxin A (SEA. Plant-derived polyphenols were incubated with the cultured Staphylococcus aureus C-29 to investigate the effects of these samples on SEA produced from C-29 using Western blot analysis. Twelve polyphenols (0.1-0.5 mg/mL inhibited the interaction between the anti-SEA antibody and SEA. We examined whether the polyphenols could directly interact with SEA after incubation of these test samples with SEA. As a result, 8 polyphenols (0.25 mg/mL significantly decreased SEA protein levels. In addition, the polyphenols that interacted with SEA inactivated the toxin activity of splenocyte proliferation induced by SEA. Polyphenols that exerted inhibitory effects on SEA toxic activity had a tendency to interact with SEA. In particular, polyphenol compounds with 1 or 2 hexahydroxydiphenoyl groups and/or a galloyl group, such as eugeniin, castalagin, punicalagin, pedunculagin, corilagin and geraniin, strongly interacted with SEA and inhibited toxin activity at a low concentration. These polyphenols may be used to prevent S. aureus infection and staphylococcal food poisoning.

  14. Antioxidant Capacity Determination in Plants and Plant-Derived Products: A Review

    Directory of Open Access Journals (Sweden)

    Aurelia Magdalena Pisoschi

    2016-01-01

    Full Text Available The present paper aims at reviewing and commenting on the analytical methods applied to antioxidant and antioxidant capacity assessment in plant-derived products. Aspects related to oxidative stress, reactive oxidative species’ influence on key biomolecules, and antioxidant benefits and modalities of action are discussed. Also, the oxidant-antioxidant balance is critically discussed. The conventional and nonconventional extraction procedures applied prior to analysis are also presented, as the extraction step is of pivotal importance for isolation and concentration of the compound(s of interest before analysis. Then, the chromatographic, spectrometric, and electrochemical methods for antioxidant and antioxidant capacity determination in plant-derived products are detailed with respect to their principles, characteristics, and specific applications. Peculiarities related to the matrix characteristics and other factors influencing the method’s performances are discussed. Health benefits of plants and derived products are described, as indicated in the original source. Finally, critical and conclusive aspects are given when it comes to the choice of a particular extraction procedure and detection method, which should consider the nature of the sample, prevalent antioxidant/antioxidant class, and the mechanism underlying each technique. Advantages and disadvantages are discussed for each method.

  15. The Last Ten Years of Advancements in Plant-Derived Recombinant Vaccines against Hepatitis B

    Science.gov (United States)

    Joung, Young Hee; Park, Se Hee; Moon, Ki-Beom; Jeon, Jae-Heung; Cho, Hye-Sun; Kim, Hyun-Soon

    2016-01-01

    Disease prevention through vaccination is considered to be the greatest contribution to public health over the past century. Every year more than 100 million children are vaccinated with the standard World Health Organization (WHO)-recommended vaccines including hepatitis B (HepB). HepB is the most serious type of liver infection caused by the hepatitis B virus (HBV), however, it can be prevented by currently available recombinant vaccine, which has an excellent record of safety and effectiveness. To date, recombinant vaccines are produced in many systems of bacteria, yeast, insect, and mammalian and plant cells. Among these platforms, the use of plant cells has received considerable attention in terms of intrinsic safety, scalability, and appropriate modification of target proteins. Research groups worldwide have attempted to develop more efficacious plant-derived vaccines for over 30 diseases, most frequently HepB and influenza. More inspiring, approximately 12 plant-made antigens have already been tested in clinical trials, with successful outcomes. In this study, the latest information from the last 10 years on plant-derived antigens, especially hepatitis B surface antigen, approaches are reviewed and breakthroughs regarding the weak points are also discussed. PMID:27754367

  16. Plant-derived additives in chicken diets as related to physical properties of eggshell

    Directory of Open Access Journals (Sweden)

    Lidia Lewko

    2015-06-01

    Full Text Available The aim of the study was to estimate the impact of the laying hen standard diet with the addition of plant-derived preparation on eggshell quality from selected Polish layer hybrids. The experimental layers were divided into three feeding groups (group I – standard diet, group II – standard diet + 5% dried herbs, group III – standard diet + 5% fresh forage. It was shown that the differences in the quality characteristics of eggshell: weight, density and colour were not statistically significant, whereas such differences (p ≤ 0.05 were confirmed in the case of the thickness. In fact the thinnest (324.15 µm eggshell had laying hens from group I – fed standard diet without plant-derived additives. Difference in comparison to group II was 2.95 µm and in relation with group III – 1.97 µm. Moreover, it was demonstrated that the most durable thus undergoing smallest deformation (27.19 µm were eggshells from laying hens fed standard diet with the addition of 5% dried herbs (group II. The difference was confirmed statistically (p ≤ 0.05 in relation with group I, that is control group fed only standard diet.

  17. The Last Ten Years of Advancements in Plant-Derived Recombinant Vaccines against Hepatitis B

    Directory of Open Access Journals (Sweden)

    Young Hee Joung

    2016-10-01

    Full Text Available Disease prevention through vaccination is considered to be the greatest contribution to public health over the past century. Every year more than 100 million children are vaccinated with the standard World Health Organization (WHO-recommended vaccines including hepatitis B (HepB. HepB is the most serious type of liver infection caused by the hepatitis B virus (HBV, however, it can be prevented by currently available recombinant vaccine, which has an excellent record of safety and effectiveness. To date, recombinant vaccines are produced in many systems of bacteria, yeast, insect, and mammalian and plant cells. Among these platforms, the use of plant cells has received considerable attention in terms of intrinsic safety, scalability, and appropriate modification of target proteins. Research groups worldwide have attempted to develop more efficacious plant-derived vaccines for over 30 diseases, most frequently HepB and influenza. More inspiring, approximately 12 plant-made antigens have already been tested in clinical trials, with successful outcomes. In this study, the latest information from the last 10 years on plant-derived antigens, especially hepatitis B surface antigen, approaches are reviewed and breakthroughs regarding the weak points are also discussed.

  18. A plant-derived anti-nociceptive spray for reduction of pain with photodynamic therapy.

    Science.gov (United States)

    Anseline, William; Grose, Douglas; Smith, Peter; Murray, Stephen; Messieh, Alfonse; Billing, Tania

    2014-12-01

    Photodynamic therapy is an effective tool in the management of some forms of skin cancer and generalized solar dermopathy and can be beneficial in the management of acne vulgaris. When used as an area treatment one of the main limiters is the quite severe burning pain that patients feel during the illumination phase of the treatment. To examine the effectiveness of a plant derived anti-nociceptive spray applied prior to and during large area photodynamic therapy. A split face or left arm versus right arm, placebo controlled trial was performed on 60 patients to assess the effectiveness of the spray in reducing pain perception. There was a statistically significant reduction in pain at all illumination points during the illumination phase but no significant difference in discomfort levels in the first 72 h post illumination. Only large area photodynamic therapy treatment was performed during the study. No conclusions can be drawn for small area treatments. Use of a simple, plant derived anti-nociceptive spray can reduce the discomfort experienced by patients undergoing photodynamic therapy to large areas. Copyright © 2014 Elsevier B.V. All rights reserved.

  19. Plant derived substances with anti-cancer activity: from folklore to practice.

    Science.gov (United States)

    Fridlender, Marcelo; Kapulnik, Yoram; Koltai, Hinanit

    2015-01-01

    Plants have had an essential role in the folklore of ancient cultures. In addition to the use as food and spices, plants have also been utilized as medicines for over 5000 years. It is estimated that 70-95% of the population in developing countries continues to use traditional medicines even today. A new trend, that involved the isolation of plant active compounds begun during the early nineteenth century. This trend led to the discovery of different active compounds that are derived from plants. In the last decades, more and more new materials derived from plants have been authorized and subscribed as medicines, including those with anti-cancer activity. Cancer is among the leading causes of morbidity and mortality worldwide. The number of new cases is expected to rise by about 70% over the next two decades. Thus, there is a real need for new efficient anti-cancer drugs with reduced side effects, and plants are a promising source for such entities. Here we focus on some plant-derived substances exhibiting anti-cancer and chemoprevention activity, their mode of action and bioavailability. These include paclitaxel, curcumin, and cannabinoids. In addition, development and use of their synthetic analogs, and those of strigolactones, are discussed. Also discussed are commercial considerations and future prospects for development of plant derived substances with anti-cancer activity.

  20. PROGRAMME OF SEMINARS MARCH TO JUNE 2004

    CERN Multimedia

    Nathalie Dumeaux

    2004-01-01

    Situation : 09.03.2004 Dates Days Places Available* Bilingual seminars Communication Techniques-1 16, 17, 18 March 3 no Project Management 17, 18, 19 March 3 yes Introduction to Management 23, 24, 25 March 3 yes Communication Techniques-1 8, 9, 10 June 3 yes Quality Management 5, 6, 7 may 3 yes Introduction to Management - Follow-up 22, 23 June 1,5 yes Seminars in English Making Presentations 22, 23 March & 1 April 3 yes Stress Management 22, 23 April 2 yes Chairing or participating in meetings 11, 12, 13 May 3 yes *If you are interested in a seminar where there are no places available, please fill in an application form and we will contact you as soon as a new session is organised. MANAGEMENT & COMMUNICATION Nathalie Dumeaux tel. 781 44 management.communication@cern.ch

  1. Proceedings of the fourth NUCEF seminar

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-07-01

    The 4th NUCEF seminar was held at JAERI Tokai Establishment on 18 February 2000. The NUCEF seminar aims at the promotion of effective researches and the encouragement of research cooperation through the discussions and information exchanges by researchers in the field on the nuclear fuel cycle back-end. This seminar was divided in the following sessions: Criticality Safety, Reprocessing/Partitioning and Radioactive Waste Management. Especially, considering highly regrettable impact of the criticality accident at JCO, the Criticality Safety session including the Dose Evaluation focused on the evaluation of JCO Criticality Accident. This report compiles the papers presented and the related discussions. The 13 of the presented papers are indexed individually. (J.P.N.)

  2. Reliability centered maintenance mini-seminar

    Energy Technology Data Exchange (ETDEWEB)

    Laakso, K.; Simola, K. (eds.) [VTT Automation, Espoo (Finland)

    2000-10-01

    In the Earlier NKS-project RAK-1 (1994-1997), the sub-project RAK-1.4, 'Maintenance Strategies and Ageing' focused on development of methodologies and tools for improving maintenance strategies. In the NKS/SOS-2 project (1998-2001), the maintenance related Nordic co-operation is continued. For exchange of information and as background and for discussions related to maintenance decisions in the NKS/SOS-2 project, a mini-seminar on maintenance strategies with an emphasis on reliability centred maintenance (RCM) approaches was arranged 14.10.1999. The report summarises the topics of the presentations and discussions at the seminar. The transparencies presented at the mini-seminar are enclosed in this report. (au)

  3. Reviving Graduate Seminar Series through Non-Technical Presentations

    Science.gov (United States)

    Madihally, Sundararajan V.

    2011-01-01

    Most chemical engineering programs that offer M.S. and Ph.D. degrees have a common seminar series for all the graduate students. Many would agree that seminars lack student interest, leading to ineffectiveness. We questioned the possibility of adding value to the seminar series by incorporating non-technical topics that may be more important to…

  4. Seminar for Master's Thesis Projects: Promoting Students' Self-Regulation

    Science.gov (United States)

    Miedijensky, Shirley; Lichtinger, Einat

    2016-01-01

    This study presents a thesis seminar model aimed at promoting students' self-regulation. Students' perceptions regarding the contribution of the seminar to their learning process were characterized and the seminar's effect upon their self-regulation expressions was examined. Data was collected using questionnaires and analyzed thematically. The…

  5. (Eds.). Resource-bounded problem solving (Dagstuhl Seminar 14341)

    NARCIS (Netherlands)

    Haxhimusa, Y.; Rooij, I.J.E.I. van; Varma, S.; Wareham, H.T.

    2014-01-01

    This report documents the program and the outcomes of Dagstuhl Seminar 14341 'Resource-bounded Problem Solving'. This seminar is a successor to Dagstuhl Seminar 11351: 'Computer Science & Problem Solving: New Foundations', held in August 2011, which was the first Dagstuhl event to bring together com

  6. L. D. Faddeev's seminar on mathematical physics

    CERN Document Server

    Semenov-Tian-Shansky, Michael

    2000-01-01

    Professor L. D. Faddeev's seminar at Steklov Mathematical Institute (St. Petersburg, Russia) has a record of more than 30 years of intensive work which has helped to shape modern mathematical physics. This collection, honoring Professor Faddeev's 65th anniversary, has been prepared by his students and colleagues. Topics covered in the volume include classical and quantum integrable systems (both analytic and algebraic aspects), quantum groups and generalizations, quantum field theory, and deformation quantization. Included is a history of the seminar highlighting important developments, such a

  7. Fourth international seminar on horizontal steam generators

    Energy Technology Data Exchange (ETDEWEB)

    Tuomisto, H. [ed.] [IVO Group, Vantaa (Finland); Purhonen, H. [ed.] [VTT, Espoo (Finland); Kouhia, V. [ed.] [Lappeenranta Univ. of Technology (Finland)

    1997-12-31

    The general objective of the International Seminars of Horizontal Steam Generator Modelling has been the improvement in understanding of realistic thermal hydraulic behaviour of the generators when performing safety analyses for VVER reactors. The main topics presented in the fourth seminar were: thermal hydraulic experiments and analyses, primary collector integrity, feedwater distributor replacement, management of primary-to-secondary leakage accidents and new developments in the VVER safety technology. The number of participants, representing designers and manufacturers of the horizontal steam generators, plant operators, engineering companies, research organizations, universities and regulatory authorities, was 70 from 10 countries.

  8. A review of Lacan's seminar on anxiety.

    Science.gov (United States)

    Diatkine, Gilbert

    2006-08-01

    The seminar on anxiety marks a turning point in the development of Lacan's thought from several perspectives. First, Lacan implicitly abandons his theory that the unconscious is structured like a language. He also abandons the endeavour to identify Freud's theory with his own. He develops some original new ideas about anxiety, some of which are of great interest, such as the connection between castration anxiety and narcissism; others, such as his denial of the existence of separation anxiety, are absurd. Lacan's main point of divergence from Freud, his rejection of the inner world, also emerges clearly in this seminar.

  9. Recombinant plant-derived pharmaceutical proteins: current technical and economic bottlenecks.

    Science.gov (United States)

    Sabalza, Maite; Christou, Paul; Capell, Teresa

    2014-12-01

    Molecular pharming is a cost-effective platform for the production of recombinant proteins in plants. Although the biopharmaceutical industry still relies on a small number of standardized fermentation-based technologies for the production of recombinant proteins there is now a greater awareness of the advantages of molecular pharming particularly in niche markets. Here we discuss some of the technical, economic and regulatory barriers that constrain the clinical development and commercialization of plant-derived pharmaceutical proteins. We also discuss strategies to increase productivity and product quality/homogeneity. The advantages of whole plants should be welcomed by the industry because this will help to reduce the cost of goods and therefore expand the biopharmaceutical market into untapped sectors.

  10. Prevention of bubonic and pneumonic plague using plant-derived vaccines.

    Science.gov (United States)

    Alvarez, M Lucrecia; Cardineau, Guy A

    2010-01-01

    Yersinia pestis, the causative agent of bubonic and pneumonic plague, is an extremely virulent bacterium but there are currently no approved vaccines for protection against this organism. Plants represent an economical and safer alternative to fermentation-based expression systems for the production of therapeutic proteins. The recombinant plague vaccine candidates produced in plants are based on the two most immunogenic antigens of Y. pestis: the fraction-1 capsular antigen (F1) and the low calcium response virulent antigen (V) either in combination or as a fusion protein (F1-V). These antigens have been expressed in plants using all three known possible strategies: nuclear transformation, chloroplast transformation and plant-virus-based expression vectors. These plant-derived plague vaccine candidates were successfully tested in animal models using parenteral, oral, or prime/boost immunization regimens. This review focuses on the recent research accomplishments towards the development of safe and effective pneumonic and bubonic plague vaccines using plants as bioreactors.

  11. Simultaneous removal of phenanthrene and cadmium from contaminated soils by saponin, a plant-derived biosurfactant.

    Science.gov (United States)

    Song, Saisai; Zhu, Lizhong; Zhou, Wenjun

    2008-12-01

    Batch experiments were conducted to evaluate the performance of saponin, a plant-derived biosurfactant, for simultaneously removing phenanthrene and cadmium from the combined contaminated soils. Results showed that phenanthrene was desorbed from the contaminated soils by saponin with the partition of phenanthrene into surfactant micelle, meanwhile cadmium was effectively removed from the contaminated soils by the complexation of cadmium with the external carboxyl groups of saponin micelle. The efficiencies of saponin for the removal of phenanthrene and cadmium from the contaminated soils were greater than that of Triton X100 and citric acid, respectively. At concentration of 3750 mg/L, saponin has a removal rate of 87.7% and 76.2% of cadmium and phenanthrene, respectively, from the combined contaminated soil. The removals of cadmium and phenanthrene from the soils were not obviously constrained each other. Thus, saponin has the potential for the removal of heavy metal and PAHs from the combined contaminated soils.

  12. Interspecific transfer of pyrrolizidine alkaloids: An unconsidered source of contaminations of phytopharmaceuticals and plant derived commodities.

    Science.gov (United States)

    Nowak, Melanie; Wittke, Carina; Lederer, Ines; Klier, Bernhard; Kleinwächter, Maik; Selmar, Dirk

    2016-12-15

    Many plant derived commodities contain traces of toxic pyrrolizidine alkaloids (PAs). The main source of these contaminations seems to be the accidental co-harvest of PA-containing weeds. Yet, based on the insights of the newly described phenomenon of the horizontal transfer of natural products, it is very likely that the PA-contaminations may also be due to an uptake of the alkaloids from the soil, previously being leached out from rotting PA-plants. The transfer of PAs was investigated using various herbs, which had been mulched with dried plant material from Senecio jacobaea. All of the acceptor plants exhibited marked concentrations of PAs. The extent and the composition of the imported PAs was dependent on the acceptor plant species. These results demonstrate that PAs indeed are leached out from dried Senecio material into the soil and confirm their uptake by the roots of the acceptor plants and the translocation into the leaves.

  13. Antibacterial activity of commercially available plant-derived essential oils against oral pathogenic bacteria.

    Science.gov (United States)

    Bardají, D K R; Reis, E B; Medeiros, T C T; Lucarini, R; Crotti, A E M; Martins, C H G

    2016-01-01

    This work investigated the antibacterial activity of 15 commercially available plant-derived essential oils (EOs) against a panel of oral pathogens. The broth microdilution method afforded the minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) of the assayed EOs. The EO obtained from Cinnamomum zeylanicum (Lauraceae) (CZ-EO) displayed moderate activity against Fusobacterium nucleatum (MIC and MBC = 125 μg/mL), Actinomyces naeslundii (MIC and MBC = 125 μg/mL), Prevotella nigrescens (MIC and MBC = 125 μg/mL) and Streptococcus mutans (MIC = 200 μg/mL; MBC = 400 μg/mL). (Z)-isosafrole (85.3%) was the main chemical component of this oil. We did not detect cinnamaldehyde, previously described as the major constituent of CZ-EO, in specimens collected in other countries.

  14. Sequestration of plant-derived glycosides by leaf beetles: A model system for evolution and adaptation

    Directory of Open Access Journals (Sweden)

    Wilhelm Boland

    2015-12-01

    Full Text Available Leaf beetles have developed an impressive repertoire of toxins and repellents to defend themselves against predators. Upon attack, the larvae discharge small droplets from glandular reservoirs on their back. The reservoirs are “bioreactors” performing the late reactions of the toxin-production from plant-derived or de novo synthesised glucosides. The import of the glucosides into the bioreactor relies on a complex transport system. Physiological studies revealed a functional network of transporters guiding the glucosides through the larval body into the defensive system. The first of the involved transporters has been identified and characterised concerning selectivity, tissue distribution, and regulation. The development of a well-tuned transport system, perfectly adjusted to the compounds provided by the food plants, provides the functional basis for the leaf beetle defenses and their local adaptation to their host plants.

  15. Plant-derived compounds stimulate the decomposition of organic matter in arctic permafrost soils

    Science.gov (United States)

    Wild, Birgit; Gentsch, Norman; Čapek, Petr; Diáková, Kateřina; Alves, Ricardo J. Eloy; Bárta, Jiři; Gittel, Antje; Hugelius, Gustaf; Knoltsch, Anna; Kuhry, Peter; Lashchinskiy, Nikolay; Mikutta, Robert; Palmtag, Juri; Schleper, Christa; Schnecker, Jörg; Shibistova, Olga; Takriti, Mounir; Torsvik, Vigdis L.; Urich, Tim; Watzka, Margarete; Šantrůčková, Hana; Guggenberger, Georg; Richter, Andreas

    2016-05-01

    Arctic ecosystems are warming rapidly, which is expected to promote soil organic matter (SOM) decomposition. In addition to the direct warming effect, decomposition can also be indirectly stimulated via increased plant productivity and plant-soil C allocation, and this so called “priming effect” might significantly alter the ecosystem C balance. In this study, we provide first mechanistic insights into the susceptibility of SOM decomposition in arctic permafrost soils to priming. By comparing 119 soils from four locations across the Siberian Arctic that cover all horizons of active layer and upper permafrost, we found that an increased availability of plant-derived organic C particularly stimulated decomposition in subsoil horizons where most of the arctic soil carbon is located. Considering the 1,035 Pg of arctic soil carbon, such an additional stimulation of decomposition beyond the direct temperature effect can accelerate net ecosystem C losses, and amplify the positive feedback to global warming.

  16. Hydroquinone; A novel bioactive compound from plant-derived smoke can cue seed germination of lettuce

    Science.gov (United States)

    Kamran, Muhammad; Khan, Abdul L.; Ali, Liaqat; Hussain, Javid; Waqas, Muhammad; Al-Harrasi, Ahmed; Imran, Qari M.; Kim, Yoon-Ha; Kang, Sang-Mo; Yun, Byung-Wook; Lee, In-Jung

    2017-05-01

    Plant-derived smoke has been known to play an important role in distribution and growth of vegetation. Using a proficiently designed furnace, we extracted smoke from the leaves of four plant viz. Helianthus annuus, Aloe vera, Ginkgo biloba, and Cymbopogon jwarancusa. Smoke dilutions obtained from these plants were obtained in different concentrations to identify potential lettuce growth promoting smoke solution. Results revealed that smoke obtained from Ginkgo biloba significantly enhanced the lettuce seed germination. This solution was then partitioned into ethyl acetate, dichloromethane, n-hexane, chloroform and ether fractions. Ethyl acetate fraction was found to be potent to enhance seed germination. This fraction was subjected to column chromatography and spectroscopic techniques to obtain compound 1. This compound was identified as hydroquinone using 1D and 2D NMR techniques. At low concentrations (5, 10 and 20 ppm), compound 1 enhanced the lettuce seed germination; however, higher concentrations inhibited its growth as compared to control.

  17. Discovery and resupply of pharmacologically active plant-derived natural products: A review.

    Science.gov (United States)

    Atanasov, Atanas G; Waltenberger, Birgit; Pferschy-Wenzig, Eva-Maria; Linder, Thomas; Wawrosch, Christoph; Uhrin, Pavel; Temml, Veronika; Wang, Limei; Schwaiger, Stefan; Heiss, Elke H; Rollinger, Judith M; Schuster, Daniela; Breuss, Johannes M; Bochkov, Valery; Mihovilovic, Marko D; Kopp, Brigitte; Bauer, Rudolf; Dirsch, Verena M; Stuppner, Hermann

    2015-12-01

    Medicinal plants have historically proven their value as a source of molecules with therapeutic potential, and nowadays still represent an important pool for the identification of novel drug leads. In the past decades, pharmaceutical industry focused mainly on libraries of synthetic compounds as drug discovery source. They are comparably easy to produce and resupply, and demonstrate good compatibility with established high throughput screening (HTS) platforms. However, at the same time there has been a declining trend in the number of new drugs reaching the market, raising renewed scientific interest in drug discovery from natural sources, despite of its known challenges. In this survey, a brief outline of historical development is provided together with a comprehensive overview of used approaches and recent developments relevant to plant-derived natural product drug discovery. Associated challenges and major strengths of natural product-based drug discovery are critically discussed. A snapshot of the advanced plant-derived natural products that are currently in actively recruiting clinical trials is also presented. Importantly, the transition of a natural compound from a "screening hit" through a "drug lead" to a "marketed drug" is associated with increasingly challenging demands for compound amount, which often cannot be met by re-isolation from the respective plant sources. In this regard, existing alternatives for resupply are also discussed, including different biotechnology approaches and total organic synthesis. While the intrinsic complexity of natural product-based drug discovery necessitates highly integrated interdisciplinary approaches, the reviewed scientific developments, recent technological advances, and research trends clearly indicate that natural products will be among the most important sources of new drugs also in the future.

  18. Adiponectin and plant-derived mammalian adiponectin homolog exert a protective effect in murine colitis

    KAUST Repository

    Arsenescu, Violeta

    2011-04-11

    Background: Hypoadiponectinemia has been associated with states of chronic inflammation in humans. Mesenteric fat hypertrophy and low adiponectin have been described in patients with Crohn\\'s disease. We investigated whether adiponectin and the plant-derived homolog, osmotin, are beneficial in a murine model of colitis. Methods: C57BL/6 mice were injected (i.v.) with an adenoviral construct encoding the full-length murine adiponectin gene (AN+DSS) or a reporter-LacZ (Ctr and V+DSS groups) prior to DSS colitis protocol. In another experiment, mice with DSS colitis received either osmotin (Osm+DSS) or saline (DSS) via osmotic pumps. Disease progression and severity were evaluated using body weight, stool consistency, rectal bleeding, colon lengths, and histology. In vitro experiments were carried out in bone marrow-derived dendritic cells. Results: Mice overexpressing adiponectin had lower expression of proinflammatory cytokines (TNF, IL-1β), adipokines (angiotensin, osteopontin), and cellular stress and apoptosis markers. These mice had higher levels of IL-10, alternative macrophage marker, arginase 1, and leukoprotease inhibitor. The plant adiponectin homolog osmotin similarly improved colitis outcome and induced robust IL-10 secretion. LPS induced a state of adiponectin resistance in dendritic cells that was reversed by treatment with PPARγ agonist and retinoic acid. Conclusion: Adiponectin exerted protective effects during murine DSS colitis. It had a broad activity that encompassed cytokines, chemotactic factors as well as processes that assure cell viability during stressful conditions. Reducing adiponectin resistance or using plant-derived adiponectin homologs may become therapeutic options in inflammatory bowel disease. © 2011 Springer Science+Business Media, LLC.

  19. REMINDER Preparation for Retirement Programme - AVS Seminar

    CERN Multimedia

    Social Service

    2001-01-01

    The AVS seminar, which had to be cancelled in March this year, will be held on: Wednesday 26 September from 14:00 to 16:00 in the Main Amphitheatre The session will be led by Mr. Lorenz STAMPFLI. The session is open to all people already registered and any other person who is interested, without the need to register.

  20. REMINDER PREPARATION FOR RETIREMENT PROGRAMME - AVS SEMINAR

    CERN Multimedia

    Social Service

    2001-01-01

    The AVS seminar, which had to be cancelled in March this year, will be held on: Wednesday 26 September from 14:00 to 16:00 in the Main Amphitheatre The session will be led by Mr. Lorenz STAMPFLI. The session is open to all people already registered and any other person who is interested, without the need to register.

  1. Third international seminar on horizontal steam generators

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-12-31

    The Third International Seminar on Horizontal Steam Generators held on October 18-20, 1994 in Lappeenranta, consisted of six sessions dealing with the topics: thermal hydraulic experiments and analyses, primary collector integrity, management of primary-to-secondary leakage accidents, feedwater collector replacement and discussion of VVER-440 steam generator safety issues.

  2. NASA STI Program Seminar: Electronic documents

    Science.gov (United States)

    1994-01-01

    The theme of this NASA Scientific and Technical Information Program Seminar was electronic documents. Topics covered included Electronic Documents Management at the CASI, the Impact of Electronic Publishing on User Expectations and Searching Image Record Management, Secondary Publisher Considerations for Electronic Journal Literature, and the Technical Manual Publishing On Demand System (TMPODS).

  3. Video Conferencing for a Virtual Seminar Room

    DEFF Research Database (Denmark)

    Forchhammer, Søren; Fosgerau, A.; Hansen, Peter Søren K.;

    2002-01-01

    A PC-based video conferencing system for a virtual seminar room is presented. The platform is enhanced with DSPs for audio and video coding and processing. A microphone array is used to facilitate audio based speaker tracking, which is used for adaptive beam-forming and automatic camera...

  4. PRAGUE SEMINAR ON LANGUAGE TEACHING AIMS, 1967.

    Science.gov (United States)

    FRIED, VILEM

    AN INTERNATIONAL SEMINAR, WHOSE PURPOSE IT WAS TO DISCUSS THE STRUCTURAL DIFFERENCES IN LANGUAGE TEACHING AIMS, IS REPORTED ON IN THIS ARTICLE. THE THREE PAPERS PRESENTED BY IVAN POLDAUF, VALENTINA ZETLINA, AND JOHN B. CARROLL ARE REVIEWED FOR THEIR DISCUSSIONS ON LINGUISTICS, DIDACTICS, AND PSYCHOLOGY. THE DISCUSSION FOLLOWING THE PRESENTATION OF…

  5. Active Magnetic Bearings. Postgraduate Seminar on Electromechanics

    Energy Technology Data Exchange (ETDEWEB)

    Lantto, E.; Tommila, V.; Arkkio, A.

    2007-07-01

    The papers in the seminar on electromagnetics are published only as power point slides. The titles of the different papers are: Introduction to magnetic bearings, Magnetic field and forces, Actuators, amplifiers and sensors, System theory, rotordynamics and control, Diagnostics, applications and standardisation.

  6. Report on Fulbright Summer Seminar on Indonesia.

    Science.gov (United States)

    Christenson, Charles Elroy

    This resource packet was compiled by a participant in the Fulbright Summer Seminar on Indonesia. The materials provide information for teaching about the diaspora of Hinduism and Islamic beliefs throughout the southeast Asia archipelagoes and their influence on art and culture. The handouts supplement information on Indonesia as part of an Asian…

  7. The Budding Yeast “Saccharomyces cerevisiae” as a Drug Discovery Tool to Identify Plant-Derived Natural Products with Anti-Proliferative Properties

    Science.gov (United States)

    Qaddouri, Bouchra; Guaadaoui, Abdelkarim; Bellirou, Ahmed; Hamal, Abdellah; Melhaoui, Ahmed; Brown, Grant W.; Bellaoui, Mohammed

    2011-01-01

    The budding yeast Saccharomyces cerevisiae is a valuable system to study cell-cycle regulation, which is defective in cancer cells. Due to the highly conserved nature of the cell-cycle machinery between yeast and humans, yeast studies are directly relevant to anticancer-drug discovery. The budding yeast is also an excellent model system for identifying and studying antifungal compounds because of the functional conservation of fungal genes. Moreover, yeast studies have also contributed greatly to our understanding of the biological targets and modes of action of bioactive compounds. Understanding the mechanism of action of clinically relevant compounds is essential for the design of improved second-generation molecules. Here we describe our methodology for screening a library of plant-derived natural products in yeast in order to identify and characterize new compounds with anti-proliferative properties. PMID:19596744

  8. The Budding Yeast “Saccharomyces cerevisiae” as a Drug Discovery Tool to Identify Plant-Derived Natural Products with Anti-Proliferative Properties

    Directory of Open Access Journals (Sweden)

    Bouchra Qaddouri

    2011-01-01

    Full Text Available The budding yeast Saccharomyces cerevisiae is a valuable system to study cell-cycle regulation, which is defective in cancer cells. Due to the highly conserved nature of the cell-cycle machinery between yeast and humans, yeast studies are directly relevant to anticancer-drug discovery. The budding yeast is also an excellent model system for identifying and studying antifungal compounds because of the functional conservation of fungal genes. Moreover, yeast studies have also contributed greatly to our understanding of the biological targets and modes of action of bioactive compounds. Understanding the mechanism of action of clinically relevant compounds is essential for the design of improved second-generation molecules. Here we describe our methodology for screening a library of plant-derived natural products in yeast in order to identify and characterize new compounds with anti-proliferative properties.

  9. CPI values of terrestrial higher plant-derived long-chain n-alkanes: a potential paleoclimatic proxy

    Institute of Scientific and Technical Information of China (English)

    Zhiguo RAO; Zhaoyu ZHU; Suping WANG; Guodong JIA; Mingrui QIANG; Yi WU

    2009-01-01

    Carbon Preference Index (CPI values) of higher plant-derived long-chain n-alkanes extracted from 62 surface soil samples in eastern China exhibited a specific pattern of variations, namely gradual increase with the increasing latitudes. Such regular variations existed in both forest soil and grassland soil. Our data implied that CPI values of higher plant-derived long-chain n-alkanes had a certain connection with climatic conditions, and such a connection was not influenced by vegetation types. Together with previous data from marine sediments, loess/ paleosol sequences, tertiary red clay and modern plants, our observation made us conclude that CPI values of higher plant-derived long-chain n-alkanes may be used as an excellent proxy for paleoclimatic studies.

  10. First international seminar on farming of invertebrates and other minillvestock

    Directory of Open Access Journals (Sweden)

    Cicogna, M.

    1992-01-01

    Full Text Available At this Seminar, held in the Philippines, minilivestock was defined as small-animal species, used as food, feed or source of revenue in given parts of the world, usually ignored by scientists trainedin industrialized countries, but very suitable and promising for small producers. The biology and use of tropical land and water snails and of manureworms, as well as different aspects of insect farming and use of insects for sericulture, food, feed or for collectors, were discussed. Sociological and extension problems connected with rural development were considered. Recent experiences of butterfly farming, tropical snail farming, use of termites and the raising of cricetoma orguinea pig for meat production were also reported. Conclusions and recommendations were drafted concerning terminology, sociological aspects, animal requirements and research, education and training needs. Minilivestock appears as a challenging new branch of animal production that offers a considerable potential for rural development, but calls for further experimental work for the optimization of production systems.

  11. Applied Ecology Seminar. Training Manual.

    Science.gov (United States)

    Office of Water Program Operations (EPA), Cincinnati, OH. National Training and Operational Technology Center.

    Presented is material on planning, administering, collecting, evaluating, interpreting, and reporting biological data related to water quality studies in both fresh and marine waters. Topics include aquatic ecology, water pollution, taxonomy, bacteriology, bioassays, water quality enhancement, and administration of water quality standards. Each of…

  12. Biologic

    CERN Document Server

    Kauffman, L H

    2002-01-01

    In this paper we explore the boundary between biology and the study of formal systems (logic). In the end, we arrive at a summary formalism, a chapter in "boundary mathematics" where there are not only containers but also extainers ><, entities open to interaction and distinguishing the space that they are not. The boundary algebra of containers and extainers is to biologic what boolean algebra is to classical logic. We show how this formalism encompasses significant parts of the logic of DNA replication, the Dirac formalism for quantum mechanics, formalisms for protein folding and the basic structure of the Temperley Lieb algebra at the foundations of topological invariants of knots and links.

  13. International Seminar on Gasification 2008

    Energy Technology Data Exchange (ETDEWEB)

    Held, Joergen (ed.)

    2008-11-15

    In total 20 international and national experts were invited to give presentations (The PPT-presentations are collected in this volume).The seminar was divided into three parts: Production technologies; Applications - Gas turbines and gas Engines - Biomethane as vehicle fuel- Syngas in industrial processes; Strategy, policy and vision. Production of synthetic fuels through gasification of biomass is expected to develop rapidly due to political ambitions related to the strong fossil fuel dependency, especially within the transportation sector, security of supply issues and the growing environmental concern. Techniques that offer a possibility to produce high quality fuels in an efficient and sustainable way are of great importance. In this context gasification is expected to play a central part. The indirect gasification concept has been further developed in recent years and there are now pilot and demonstration plants as well as commercial plants in operation. The RandD activities at the semi-industrial plant in Guessing, Austria have resulted in the first commercial plant, in Oberwart. The design data is 8.5 MW{sub th} and 2.7 MW{sub e} which gives an electric efficiency of 32 % and the possibility to produce biomethane. In this scale conventional CHP production based on combustion of solid biomass and the steam cycle would result in a poor electric efficiency. Metso Power has complemented the 12 MW{sub th} CFB-boiler at Chalmers University of Technology, Gothenburg, Sweden with a 2 MW{sub th} indirect gasifier. The gasifier is financed by Gothenburg Energy and built for RD purposes. Gothenburg Energy in collaboration with E.ON Sweden will in a first stage build a 20 MW plant for biomethane production (as vehicle fuel and for grid injection) in Gothenburg based on the indirect gasification technology. The plant is expected to be in operation in 2012. The next stage involves an 80 MW plant with a planned start of operation in 2015. Indirect gasification of biomass

  14. International Seminar on Gasification 2008

    Energy Technology Data Exchange (ETDEWEB)

    Held, Joergen (ed.)

    2008-11-15

    In total 20 international and national experts were invited to give presentations (The PPT-presentations are collected in this volume).The seminar was divided into three parts: Production technologies; Applications - Gas turbines and gas Engines - Biomethane as vehicle fuel- Syngas in industrial processes; Strategy, policy and vision. Production of synthetic fuels through gasification of biomass is expected to develop rapidly due to political ambitions related to the strong fossil fuel dependency, especially within the transportation sector, security of supply issues and the growing environmental concern. Techniques that offer a possibility to produce high quality fuels in an efficient and sustainable way are of great importance. In this context gasification is expected to play a central part. The indirect gasification concept has been further developed in recent years and there are now pilot and demonstration plants as well as commercial plants in operation. The RandD activities at the semi-industrial plant in Guessing, Austria have resulted in the first commercial plant, in Oberwart. The design data is 8.5 MW{sub th} and 2.7 MW{sub e} which gives an electric efficiency of 32 % and the possibility to produce biomethane. In this scale conventional CHP production based on combustion of solid biomass and the steam cycle would result in a poor electric efficiency. Metso Power has complemented the 12 MW{sub th} CFB-boiler at Chalmers University of Technology, Gothenburg, Sweden with a 2 MW{sub th} indirect gasifier. The gasifier is financed by Gothenburg Energy and built for RD purposes. Gothenburg Energy in collaboration with E.ON Sweden will in a first stage build a 20 MW plant for biomethane production (as vehicle fuel and for grid injection) in Gothenburg based on the indirect gasification technology. The plant is expected to be in operation in 2012. The next stage involves an 80 MW plant with a planned start of operation in 2015. Indirect gasification of biomass

  15. Nanocoating with plant-derived pectins activates osteoblast response in vitro

    Science.gov (United States)

    Folkert, J; Meresta, A; Gaber, T; Miksch, K; Buttgereit, F; Detert, J; Pischon, N; Gurzawska, K

    2017-01-01

    A new strategy to improve osseointegration of implants is to stimulate adhesion of bone cells, bone matrix formation, and mineralization at the implant surface by modifying surface coating on the nanoscale level. Plant-derived pectins have been proposed as potential candidates for surface nanocoating of orthopedic and dental titanium implants due to 1) their osteogenic stimulation of osteoblasts to mineralize and 2) their ability to control pectin structural changes. The aim of this study was to evaluate in vitro the impact of the nanoscale plant-derived pectin Rhamnogalacturonan-I (RG-I) from potato on the osteogenic response of murine osteoblasts. RG-I from potato pulps was isolated, structurally modified, or left unmodified. Tissue culture plates were either coated with modified RG-I or unmodified RG-I or – as a control – left uncoated. The effect of nanocoating on mice osteoblast-like cells MC3T3-E1 and primary murine osteoblast with regard to proliferation, osteogenic response in terms of mineralization, and gene expression of Runt-related transcription factor 2 (Runx2), alkaline phosphate (Alpl), osteocalcin (Bglap), α-1 type I collagen (Col1a1), and receptor activator of NF-κB ligand (Rankl) were analyzed after 3, 7, 14, and 21 days, respectively. Nanocoating with pectin RG-Is increased proliferation and mineralization of MC3T3-E1 and primary osteoblast as compared to osteoblasts cultured without nanocoating. Moreover, osteogenic transcriptional response of osteoblasts was induced by nanocoating in terms of gene induction of Runx2, Alpl, Bglap, and Col1a1 in a time-dependent manner – of note – to the highest extent under the PA-coating condition. In contrast, Rankl expression was initially reduced by nanocoating in MC3T3-E1 or remained unaltered in primary osteoblast as compared to the uncoated controls. Our results showed that nanocoating of implants with modified RG-I beneficially 1) supports osteogenesis, 2) has the capacity to improve

  16. Clean coal technologies---An international seminar: Seminar evaluation and identification of potential CCT markets

    Energy Technology Data Exchange (ETDEWEB)

    Guziel, K.A.; Poch, L.A.; Gillette, J.L.; Buehring, W.A.

    1991-07-01

    The need for environmentally responsible electricity generation is a worldwide concern. Because coal is available throughout the world at a reasonable cost, current research is focusing on technologies that use coal with minimal environmental effects. The United States government is supporting research on clean coal technologies (CCTs) to be used for new capacity additions and for retrofits to existing capacity. To promote the worldwide adoption of US CCTs, the US Department of Energy, the US Agency for International Development, and the US Trade and Development Program sponsored a two-week seminar titled Clean Coal Technologies -- An International Seminar. Nineteen participants from seven countries were invited to this seminar, which was held at Argonne National Laboratory in June 1991. During the seminar, 11 US CCT vendors made presentations on their state-of-the-art and commercially available technologies. The presentations included technical, environmental, operational, and economic characteristics of CCTs. Information on financing and evaluating CCTs also was presented, and participants visited two CCT operating sites. The closing evaluation indicated that the seminar was a worthwhile experience for all participants and that it should be repeated. The participants said CCT could play a role in their existing and future electric capacity, but they agreed that more CCT demonstration projects were needed to confirm the reliability and performance of the technologies.

  17. Programme of Seminars January to March 2004

    CERN Multimedia

    2004-01-01

    If you wish to participate in one of the following courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at: http://www.cern.ch/Training/ or fill in an "application for training" form available from your Divisional Secretariat or from your DTO (Divisional Training Officer). Applications will be accepted in the order of their receipt. MANAGEMENT & COMMUNICATION Nathalie Dumeaux tel. 78144 management.communication@cern.ch Situation : 20.01.2004 DatesDaysPlaces Available** Bilingual seminars Communication Techniques-1/Techniques de communication-1 16, 17, 18 March 3 non Project Management/Gestion de projet 17, 18, 19 March 3 oui Seminars in English Communicating effectively 22, 23 January & 19, 20 February 4 yes Performance Appraisal MAPS 4, 5, 6 February 3 yes Performance Appraisal -MAPS 11, 12, 13 February 3 yes Séminaires en Français Formation à l'entreti...

  18. Rapid Analytical Method for the Determination of Aflatoxins in Plant-Derived Dietary Supplement and Cosmetic Oils

    Science.gov (United States)

    Consumption of edible oils derived from conventional crop plants is increasing because they are generally regarded as more healthy alternatives to animal based fats and oils. More recently there has been increased interest in the use of alternative specialty plant-derived oils, including those from...

  19. Seminar at the University of Texas

    CERN Document Server

    Rosenthal, Haskell

    1988-01-01

    The articles in this volume are based on talks given in a seminar at Austin during 1986-87. They range from those dealing with fresh research and discoveries to exposition and new proofs of older results. The main topics and themes include geometric and analytic properties of infinite-dimensional Banach spaces and their convex subsets as well as some aspects of Banach spaces associated with harmonic analysis and Banach algebras.

  20. 1990 fuel cell seminar: Program and abstracts

    Energy Technology Data Exchange (ETDEWEB)

    1990-12-31

    This volume contains author prepared short resumes of the presentations at the 1990 Fuel Cell Seminar held November 25-28, 1990 in Phoenix, Arizona. Contained herein are 134 short descriptions organized into topic areas entitled An Environmental Overview, Transportation Applications, Technology Advancements for Molten Carbonate Fuel Cells, Technology Advancements for Solid Fuel Cells, Component Technologies and Systems Analysis, Stationary Power Applications, Marine and Space Applications, Technology Advancements for Acid Type Fuel Cells, and Technology Advancement for Solid Oxide Fuel Cells.

  1. Seminar on waste treatment and disposal

    Energy Technology Data Exchange (ETDEWEB)

    Sneve, Malgorzata Karpow; Snihs, Jan Olof

    1999-07-01

    Leading abstract. A seminar on radioactive waste treatment and disposal was held 9 - 14 November 1998 in Oskarshamn, Sweden. The objective of the seminar was to exchange information on national and international procedures, practices and requirements for waste management. This information exchange was intended to promote the development of a suitable strategy for management of radioactive waste in Northwest Russia to be used as background for future co-operation in the region. The seminar focused on (1) overviews of international co-operation in the waste management field and national systems for waste management, (2) experiences from treatment of low- and intermediate-level radioactive waste, (3) the process of determining the options for final disposal of radioactive waste, (4) experiences from performance assessments and safety analysis for repositories intended for low- and intermediate level radioactive waste, (5) safety of storage and disposal of high-level waste. The seminar was jointly organised and sponsored by the Swedish Radiation Protection Institute (SSI), the Norwegian Radiation Protection Authority (NRPA), the Nordic Nuclear Safety Research (NKS) and the European Commission. A Russian version of the report is available. In brief, the main conclusions are: (1) It is the prerogative of the Russian federal Government to devise and implement a waste management strategy without having to pay attention to the recommendations of the meeting, (2) Some participants consider that many points have already been covered in existing governmental documents, (3) Norway and Sweden would like to see a strategic plan in order to identify how and where to co-operate best, (4) There is a rigorous structure of laws in place, based on over-arching environmental laws, (5) Decommissioning of submarines is a long and complicated task, (6) There are funds and a desire for continued Norway/Sweden/Russia co-operation, (7) Good co-operation is already taking place.

  2. Seminar: Music Therapy in Dementia Care

    DEFF Research Database (Denmark)

    Ridder, Hanne Mette Ochsner

    2009-01-01

    This seminar presents music therapy in person centered dementia care. In the first part focus is on research and documentation. How can short term music therapy document changes in symptoms of depression? Is Dementia Care Mapping a valid assessment tool for documenting group music therapy......? In the next part focus is on clinical music therapy – in group work as well as in individual work – and how the music therapist works in the interdisciplinary field....

  3. Civilian Crisis Response Models (Dagstuhl Seminar 13041)

    OpenAIRE

    Katzy, Bernhard; Lechner, Ulrike

    2013-01-01

    This report documents the program and the outcomes of Dagstuhl Seminar 13041 "Civilian Crisis Response Models". The vulnerability of modern societies to the threats of man made and natural disaster increases and scale and number of disasters are expected to rise. The earthquakes of Haiti with its subsequent Cholera epidemics, the natural disasters in Pakistan as well as the ongoing situation in Japan illustrate the need for effective and efficient crisis and disaster response organization...

  4. High temperature electronics and instrumentation seminar proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Veneruso, A.F.; Arnold, C.; Simpson, R.S. (eds.)

    1980-05-01

    This seminar was tailored to address the needs of the borehole logging industry and to stimulate the development and application of this technology, for logging geothermal, hot oil and gas, and steam injection wells. The technical sessions covered the following topics: hybrid circuits, electronic devices, transducers, cables and connectors, materials, mechanical tools and thermal protection. Thirty-eight papers are included. Separate entries were prepared for each one. (MHR)

  5. High temperature electronics and instrumentation seminar proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Veneruso, A.F.; Arnold, C.; Simpson, R.S. (eds.)

    1980-05-01

    This seminar was tailored to address the needs of the borehole logging industry and to stimulate the development and application of this technology, for logging geothermal, hot oil and gas, and steam injection wells. The technical sessions covered the following topics: hybrid circuits, electronic devices, transducers, cables and connectors, materials, mechanical tools and thermal protection. Thirty-eight papers are included. Separate entries were prepared for each one. (MHR)

  6. Seminar: Music Therapy in Dementia Care

    DEFF Research Database (Denmark)

    Ridder, Hanne Mette Ochsner

    2009-01-01

    This seminar presents music therapy in person centered dementia care. In the first part focus is on research and documentation. How can short term music therapy document changes in symptoms of depression? Is Dementia Care Mapping a valid assessment tool for documenting group music therapy......? In the next part focus is on clinical music therapy – in group work as well as in individual work – and how the music therapist works in the interdisciplinary field....

  7. A plant derived multifunctional tool for nanobiotechnology based on Tomato bushy stunt virus.

    Science.gov (United States)

    Grasso, Simone; Lico, Chiara; Imperatori, Francesca; Santi, Luca

    2013-06-01

    Structure, size, physicochemical properties and production strategies make many plant viruses ideal protein based nanoscaffolds, nanocontainers and nano-building blocks expected to deliver a multitude of applications in different fields such as biomedicine, pharmaceutical chemistry, separation science, catalytic chemistry, crop pest control and biomaterials science. Functionalization of viral nanoparticles through modification by design of their external and internal surfaces is essential to fully exploit the potentiality of these objects. In the present paper we describe the development of a plant derived multifunctional tool for nanobiotechnology based on Tomato bushy stunt virus. We demonstrate the ability of this system to remarkably sustain genetic modifications and in vitro chemical derivatizations of its outer surface, which resulted in the successful display of large chimeric peptides fusions and small chemical molecules, respectively. Moreover, we have defined physicochemical conditions for viral swelling and reversible viral pore gating that we have successfully employed for foreign molecules loading and retention in the inner cavity of this plant virus nanoparticles system. Finally, a production and purification strategy from Nicotiana benthamiana plants has been addressed and optimized.

  8. Cardioprotective Potentials of Plant-Derived Small Molecules against Doxorubicin Associated Cardiotoxicity

    Directory of Open Access Journals (Sweden)

    Shreesh Ojha

    2016-01-01

    Full Text Available Doxorubicin (DOX is a potent and widely used anthracycline antibiotic for the treatment of several malignancies. Unfortunately, the clinical utility of DOX is often restricted due to the elicitation of organ toxicity. Particularly, the increased risk for the development of dilated cardiomyopathy by DOX among the cancer survivors warrants major attention from the physicians as well as researchers to develop adjuvant agents to neutralize the noxious effects of DOX on the healthy myocardium. Despite these pitfalls, the use of traditional cytotoxic drugs continues to be the mainstay treatment for several types of cancer. Recently, phytochemicals have gained attention for their anticancer, chemopreventive, and cardioprotective activities. The ideal cardioprotective agents should not compromise the clinical efficacy of DOX and should be devoid of cumulative or irreversible toxicity on the naïve tissues. Furthermore, adjuvants possessing synergistic anticancer activity and quelling of chemoresistance would significantly enhance the clinical utility in combating DOX-induced cardiotoxicity. The present review renders an overview of cardioprotective effects of plant-derived small molecules and their purported mechanisms against DOX-induced cardiotoxicity. Phytochemicals serve as the reservoirs of pharmacophore which can be utilized as templates for developing safe and potential novel cardioprotective agents in combating DOX-induced cardiotoxicity.

  9. The Antitumor Activity of Plant-Derived Non-Psychoactive Cannabinoids.

    Science.gov (United States)

    McAllister, Sean D; Soroceanu, Liliana; Desprez, Pierre-Yves

    2015-06-01

    As a therapeutic agent, most people are familiar with the palliative effects of the primary psychoactive constituent of Cannabis sativa (CS), Δ(9)-tetrahydrocannabinol (THC), a molecule active at both the cannabinoid 1 (CB1) and cannabinoid 2 (CB2) receptor subtypes. Through the activation primarily of CB1 receptors in the central nervous system, THC can reduce nausea, emesis and pain in cancer patients undergoing chemotherapy. During the last decade, however, several studies have now shown that CB1 and CB2 receptor agonists can act as direct antitumor agents in a variety of aggressive cancers. In addition to THC, there are many other cannabinoids found in CS, and a majority produces little to no psychoactivity due to the inability to activate cannabinoid receptors. For example, the second most abundant cannabinoid in CS is the non-psychoactive cannabidiol (CBD). Using animal models, CBD has been shown to inhibit the progression of many types of cancer including glioblastoma (GBM), breast, lung, prostate and colon cancer. This review will center on mechanisms by which CBD, and other plant-derived cannabinoids inefficient at activating cannabinoid receptors, inhibit tumor cell viability, invasion, metastasis, angiogenesis, and the stem-like potential of cancer cells. We will also discuss the ability of non-psychoactive cannabinoids to induce autophagy and apoptotic-mediated cancer cell death, and enhance the activity of first-line agents commonly used in cancer treatment.

  10. Solubilization properties of polycyclic aromatic hydrocarbons by saponin, a plant-derived biosurfactant.

    Science.gov (United States)

    Zhou, Wenjun; Yang, Juanjuan; Lou, Linjie; Zhu, Lizhong

    2011-05-01

    The enhanced solubilization of polycyclic aromatic hydrocarbons (PAHs) by saponin, a plant-derived non-ionic biosurfactant, was investigated. The results indicated that the solubilization capabilities of saponin for PAHs were greater than some representative synthetic non-ionic surfactants and showed strong dependence on solution pH and ionic strength. The molar solubilization ratio (MSR) of saponin for phenanthrene was about 3-6 times of those of the synthetic non-ionic surfactants, and decreased by about 70% with the increase of solution pH from 4.0 to 8.0, but increased by approximately 1 times with NaCl concentration increased from 0.01 to 1.0 M. Heavy metal ions can enhance saponin solubilization for phenanthrene and the corresponding MSR values increased by about 25% with the presence of 0.01 M of Cd2+ or Zn2+. Saponin is more effective in enhancing PAHs solubilization than synthetic non-ionic surfactants and has potential application in removing organic pollutants from contaminated soils.

  11. Simultaneous removal of phenanthrene and cadmium from contaminated soils by saponin, a plant-derived biosurfactant

    Energy Technology Data Exchange (ETDEWEB)

    Song Saisai [Department of Environmental Science, Zhejiang University, Hangzhou, Zhejiang 310028 (China); Zhu Lizhong [Department of Environmental Science, Zhejiang University, Hangzhou, Zhejiang 310028 (China)], E-mail: zlz@zju.edu.cn; Zhou Wenjun [Department of Environmental Science, Zhejiang University, Hangzhou, Zhejiang 310028 (China)

    2008-12-15

    Batch experiments were conducted to evaluate the performance of saponin, a plant-derived biosurfactant, for simultaneously removing phenanthrene and cadmium from the combined contaminated soils. Results showed that phenanthrene was desorbed from the contaminated soils by saponin with the partition of phenanthrene into surfactant micelle, meanwhile cadmium was effectively removed from the contaminated soils by the complexation of cadmium with the external carboxyl groups of saponin micelle. The efficiencies of saponin for the removal of phenanthrene and cadmium from the contaminated soils were greater than that of Triton X100 and citric acid, respectively. At concentration of 3750 mg/L, saponin has a removal rate of 87.7% and 76.2% of cadmium and phenanthrene, respectively, from the combined contaminated soil. The removals of cadmium and phenanthrene from the soils were not obviously constrained each other. Thus, saponin has the potential for the removal of heavy metal and PAHs from the combined contaminated soils. - Saponin has great potential for the simultaneous removal of cadmium and phenanthrene from the combined contaminated soils.

  12. Investigations of plant-derived products with the in vitro comet assay

    Directory of Open Access Journals (Sweden)

    Luc Verschaeve

    2015-08-01

    It is impossible to perform a wide range of tests for screening purposes and often only the Ames assay is performed, which is insufficient. Furthermore, this test is most probably not the best choice when plant extracts need to be tested, because they often contain high amounts of histidine and have antibacterial properties. We have participated in many screening programs of medicinal plants and used different genotoxicity tests (mainly Ames assay, Vitotox test, micronucleus test and comet assay. Or results revealed that a combination of the Vitotox test and comet assay provides sufficiently reliable data with respect to genotoxicity as well as antigenotoxicity. This holds true for the testing of (medicinal plant extracts but also other plant derived products, for example those aimed at identifying novel TB chemotherapeutic drugs. The investigation of smoke and smoke compounds as enhancers of seed germination and smoke treated plants provides another example in which the comet assay proved to be valuable in the assessment of potential adverse health effects resulting from such treatment.

  13. Antibacterial activities of plant-derived compounds and essential oils toward Cronobacter sakazakii and Cronobacter malonaticus.

    Science.gov (United States)

    Fraňková, Adéla; Marounek, Milan; Mozrová, Věra; Weber, Jaroslav; Klouček, Pavel; Lukešová, Daniela

    2014-10-01

    Cronobacter sakazakii and C. malonaticus are opportunistic pathogens that cause infections in children and immunocompromised adults. In the present study, the antibacterial activity of 19 plant-derived compounds, 5 essential oils, and an extract of propolis were assessed against C. sakazakii and C. malonaticus. The effects of most of these antimicrobials have not been reported previously. Both strains were susceptible to thymol, carvacrol, thymoquinone, p-cymene, linalool, camphor, citral, eugenol, and trans-cinnamaldehyde as well as cinnamon, lemongrass, oregano, clove, and laurel essential oils; their minimum inhibitory concentrations varied between 0.1 and 2.0 mg/mL. As an alternative treatment method, vapors of the volatiles were tested as an indirect treatment. Vapors of trans-cinnamaldehyde, eugenol, oregano, and cinnamon essential oils inhibited both tested strains, while vapors of linalool were only active against C. sakazakii. To our knowledge, this study is the first time that the inhibitory activity of the vapors of these compounds and essential oils has been reported against Cronobacter spp.

  14. In silico approach for the discovery of new PPARγ modulators among plant-derived polyphenols.

    Science.gov (United States)

    Encinar, José Antonio; Fernández-Ballester, Gregorio; Galiano-Ibarra, Vicente; Micol, Vicente

    2015-01-01

    Peroxisome proliferator-activated receptor gamma (PPARγ) is a well-characterized member of the PPAR family that is predominantly expressed in adipose tissue and plays a significant role in lipid metabolism, adipogenesis, glucose homeostasis, and insulin sensitization. Full agonists of synthetic thiazolidinediones (TZDs) have been therapeutically used in clinical practice to treat type 2 diabetes for many years. Although it can effectively lower blood glucose levels and improve insulin sensitivity, the administration of TZDs has been associated with severe side effects. Based on recent evidence obtained with plant-derived polyphenols, the present in silico study aimed at finding new selective human PPARγ (hPPARγ) modulators that are able to improve glucose homeostasis with reduced side effects compared with TZDs. Docking experiments have been used to select compounds with strong binding affinity (ΔG values ranging from -10.0±0.9 to -11.4±0.9 kcal/mol) by docking against the binding site of several X-ray structures of hPPARγ. These putative modulators present several molecular interactions with the binding site of the protein. Additionally, most of the selected compounds have favorable druggability and good ADMET properties. These results aim to pave the way for further bench-scale analysis for the discovery of new modulators of hPPARγ that do not induce any side effects.

  15. The endocannabinoid system and plant-derived cannabinoids in diabetes and diabetic complications.

    Science.gov (United States)

    Horváth, Béla; Mukhopadhyay, Partha; Haskó, György; Pacher, Pál

    2012-02-01

    Oxidative stress and inflammation play critical roles in the development of diabetes and its complications. Recent studies provided compelling evidence that the newly discovered lipid signaling system (ie, the endocannabinoid system) may significantly influence reactive oxygen species production, inflammation, and subsequent tissue injury, in addition to its well-known metabolic effects and functions. The modulation of the activity of this system holds tremendous therapeutic potential in a wide range of diseases, ranging from cancer, pain, neurodegenerative, and cardiovascular diseases to obesity and metabolic syndrome, diabetes, and diabetic complications. This review focuses on the role of the endocannabinoid system in primary diabetes and its effects on various diabetic complications, such as diabetic cardiovascular dysfunction, nephropathy, retinopathy, and neuropathy, particularly highlighting the mechanisms beyond the metabolic consequences of the activation of the endocannabinoid system. The therapeutic potential of targeting the endocannabinoid system and certain plant-derived cannabinoids, such as cannabidiol and Δ9-tetrahydrocannabivarin, which are devoid of psychotropic effects and possess potent anti-inflammatory and/or antioxidant properties, in diabetes and diabetic complications is also discussed.

  16. Effects of feeding plant-derived agents on the colonization of Campylobacter jejuni in broiler chickens.

    Science.gov (United States)

    Kurekci, Cemil; Al Jassim, Rafat; Hassan, Errol; Bishop-Hurley, Sharon L; Padmanabha, Jagadish; McSweeney, Christopher S

    2014-09-01

    The aim of this work was to test the potential use of plant-derived extracts and compounds to control Campylobacter jejuni in broiler chickens. Over a 7-wk feeding period, birds were fed a commercial diet with or without plant extracts (Acacia decurrens, Eremophila glabra), essential oil [lemon myrtle oil (LMO)], plant secondary compounds [terpinene-4-ol and α-tops (including α-terpineol, cineole, and terpinene-4-ol)], and the antibiotic virginiamycin. Traditional culture and real-time quantitative PCR techniques were used to enumerate the numbers of C. jejuni in chicken fecal and cecal samples. In addition, BW and feed intake were recorded weekly for the calculation of BW gain and feed conversion ratio. The mean log10 counts of C. jejuni were similar (P > 0.05) across treatments. However, significantly lower levels of fecal Campylobacter counts (P 0.05) in BW gain were obtained for dietary supplementation, except for the E. glabra extract, which had a negative impact (P < 0.001) on BW, resulting in sporadic death. Results from this study suggest that supplemental natural compounds used in the current study did not reduce the shedding of C. jejuni to desired levels.

  17. Plant-Derived Tick Repellents Activate the Honey Bee Ectoparasitic Mite TRPA1

    Directory of Open Access Journals (Sweden)

    Guangda Peng

    2015-07-01

    Full Text Available We have identified and characterized the TRPA1 channel of Varroa destructor (VdTRPA1, a major ectoparasitic mite of honey bee. One of the two VdTRPA1 isoforms, VdTRPA1L, was activated by a variety of plant-derived compounds, including electrophilic compounds, suggesting that chemical activation profiles are mostly shared between arthropod TRPA1 channels. Nevertheless, carvacrol and α-terpineol activated VdTRPA1L but not a honey bee noxious-stimuli-sensitive TRPA, AmHsTRPA, and Drosophila melanogaster TRPA1. Activation of VdTRPA1L in D. melanogaster taste neurons by the above compounds was sufficient to modify the gustatory behaviors. Carvacrol and α-terpineol repelled V. destructor in a laboratory assay, and α-terpineol repressed V. destructor entry for reproduction into the brood cells in hives. Understanding the functions of parasite TRP channels not only gives clues about the evolving molecular and cellular mechanisms of parasitism but also helps in the development of control methods.

  18. Plants-Derived Neuroprotective Agents: Cutting the Cycle of Cell Death through Multiple Mechanisms

    Directory of Open Access Journals (Sweden)

    Taiwo Olayemi Elufioye

    2017-01-01

    Full Text Available Neuroprotection is the preservation of the structure and function of neurons from insults arising from cellular injuries induced by a variety of agents or neurodegenerative diseases (NDs. The various NDs including Alzheimer’s, Parkinson’s, and Huntington’s diseases as well as amyotropic lateral sclerosis affect millions of people around the world with the main risk factor being advancing age. Each of these diseases affects specific neurons and/or regions in the brain and involves characteristic pathological and molecular features. Hence, several in vitro and in vivo study models specific to each disease have been employed to study NDs with the aim of understanding their underlying mechanisms and identifying new therapeutic strategies. Of the most prevalent drug development efforts employed in the past few decades, mechanisms implicated in the accumulation of protein-based deposits, oxidative stress, neuroinflammation, and certain neurotransmitter deficits such as acetylcholine and dopamine have been scrutinized in great detail. In this review, we presented classical examples of plant-derived neuroprotective agents by highlighting their structural class and specific mechanisms of action. Many of these natural products that have shown therapeutic efficacies appear to be working through the above-mentioned key multiple mechanisms of action.

  19. Solubilization properties of polycyclic aromatic hydrocarbons by saponin, a plant-derived biosurfactant

    Energy Technology Data Exchange (ETDEWEB)

    Zhou Wenjun, E-mail: wenjunzhou@zju.edu.cn [Department of Environmental Science, Zhejiang University, Hangzhou, Zhejiang 310028 (China); Zhejiang Provincial Key Laboratory of Organic Pollution Process and Control, Hangzhou, Zhejiang 310028 (China); Yang Juanjuan; Lou Linjie [Department of Environmental Science, Zhejiang University, Hangzhou, Zhejiang 310028 (China); Zhu Lizhong [Department of Environmental Science, Zhejiang University, Hangzhou, Zhejiang 310028 (China); Zhejiang Provincial Key Laboratory of Organic Pollution Process and Control, Hangzhou, Zhejiang 310028 (China)

    2011-05-15

    The enhanced solubilization of polycyclic aromatic hydrocarbons (PAHs) by saponin, a plant-derived non-ionic biosurfactant, was investigated. The results indicated that the solubilization capabilities of saponin for PAHs were greater than some representative synthetic non-ionic surfactants and showed strong dependence on solution pH and ionic strength. The molar solubilization ratio (MSR) of saponin for phenanthrene was about 3-6 times of those of the synthetic non-ionic surfactants, and decreased by about 70% with the increase of solution pH from 4.0 to 8.0, but increased by approximately 1 times with NaCl concentration increased from 0.01 to 1.0 M. Heavy metal ions can enhance saponin solubilization for phenanthrene and the corresponding MSR values increased by about 25% with the presence of 0.01 M of Cd{sup 2+} or Zn{sup 2+}. Saponin is more effective in enhancing PAHs solubilization than synthetic non-ionic surfactants and has potential application in removing organic pollutants from contaminated soils. - Highlights: > The enhanced solubilization of PAHs by saponin was investigated in this study. > Saponin showed great solubilization capability for PAHs. > Saponin is more effective in enhancing HOCs solubilization at lower solution pH. > Increasing ionic strength can enhance HOCs solubilization in saponin solution. > Heavy metal ions can also enhance phenanthrene solubilization in saponin solution. - Saponin showed different solubilization properties for PAHs from the synthetic non-ionic surfactants and anionic rhamnolipid biosurfactants.

  20. Plant-derived natural medicines for the management of depression: an overview of mechanisms of action.

    Science.gov (United States)

    Farahani, Marzieh Sarbandi; Bahramsoltani, Roodabeh; Farzaei, Mohammad Hosein; Abdollahi, Mohammad; Rahimi, Roja

    2015-01-01

    Depression is a serious widespread psychiatric disorder that affects approximately 17% of people all over the world. Exploring the neurological mechanisms of the antidepressant activity of plant-derived agents could have a crucial role in developing natural drugs for the management of depression. The aim of the present study is to review the neurological mechanisms of action of antidepressant plants and their constituents. For this purpose, electronic databases, including PubMed, Science Direct, Scopus, and Cochrane Library, were searched from 1966 to October 2013. The results showed that several molecular mechanisms could be proposed for the antidepressant activity of medicinal plants and their constituents. Hypericum species could normalize brain serotonin level. Liquiritin and isoliquiritin from Glycyrrhiza uralensis rhizome act via the noradrenergic system. Rosmarinus officinalis and curcumin from Curcuma longa interact with D1 and D2 receptors as well as elevate the brain dopamine level. Sida tiagii and Aloysia gratissima involve γ-aminobutyric acid and N-methyl-D-aspartate receptors, respectively. Fuzi polysaccharide-1 from Aconitum carmichaeli could affect brain-derived neurotrophic factor signaling pathways. Psoralidin from Psoralea corylifolia seed modulate the hypothalamic-pituitary-adrenal axis. The total glycosides of Paeonia lactiflora demonstrate an inhibitory effect on both subtypes of monoamine oxidase. 3,6'-Di-o-sinapoyl-sucrose and tenuifoliside A from Polygala tenuifolia exhibit cytoprotective effects on neuronal cells. Further preclinical and clinical trials evaluating their safety, bioefficacy, and bioavailability are suggested to prove the valuable role of natural drugs in the management of depressive disorders.

  1. Quality of Experience: From Assessment to Application (Dagstuhl Seminar 15022)

    OpenAIRE

    De Moor, Katrien; Fiedler, Markus; Reichl, Peter; Varela, Martín

    2015-01-01

    This report provides an overview of the program, discussions and outcomes of Dagstuhl Seminar 15022 "Quality of Experience: From Assessment to Application", which took place from 4 - 7 January 2015 at Schloss Dagstuhl - Leibniz Center for Informatics. The seminar and the challenges that were addressed have their roots in the earlier Dagstuhl Seminars 09192 "From Quality of Service to Quality of Experience" and 12181 "Quality of Experience: From User Perception to Instrumental Metrics". The ma...

  2. Graph Drawing with Algorithm Engineering Methods (Dagstuhl Seminar 11191)

    OpenAIRE

    Demetrescu, Camil; Kaufmann, Michael; Kobourov, Stephen; Mutzel, Petra

    2011-01-01

    This report documents the program and the outcomes of Dagstuhl Seminar 11191 ``Graph Drawing with Algorithm Engineering Methods''. We summarize the talks, open problems, and working group discussions.

  3. Plant-derived SAC domain of PAR-4 (Prostate Apoptosis Response 4 exhibits growth inhibitory effects in prostate cancer cells

    Directory of Open Access Journals (Sweden)

    Shayan eSarkar

    2015-10-01

    Full Text Available The gene Par-4 (Prostate Apoptosis Response 4 was originally identified in prostate cancer cells undergoing apoptosis and its product Par-4 showed cancer specific pro-apoptotic activity. Particularly, the SAC domain of Par-4 (SAC-Par-4 selectively kills cancer cells leaving normal cells unaffected. The therapeutic significance of bioactive SAC-Par-4 is enormous in cancer biology; however, its large scale production is still a matter of concern. Here we report the production of SAC-Par-4-GFP fusion protein coupled to translational enhancer sequence (5′ AMV and apoplast signal peptide (aTP in transgenic Nicotiana tabacum cv. Samsun NN plants under the control of a unique recombinant promoter M24. Transgene integration was confirmed by genomic DNA PCR, Southern and Northern blotting, Real-time PCR and Nuclear run-on assays. Results of Western blot analysis and ELISA confirmed expression of recombinant SAC-Par-4-GFP protein and it was as high as 0.15% of total soluble protein. In addition, we found that targeting of plant recombinant SAC-Par-4-GFP to the apoplast and endoplasmic reticulum (ER was essential for the stability of plant recombinant protein in comparison to the bacterial derived SAC-Par-4. Deglycosylation analysis demonstrated that ER-targeted SAC-Par-4-GFP-SEKDEL undergoes O-linked glycosylation unlike apoplast-targeted SAC-Par-4-GFP. Furthermore, various in vitro studies like mammalian cells proliferation assay (MTT, apoptosis induction assays, and NF-κB suppression suggested the cytotoxic and apoptotic properties of plant-derived SAC-Par-4-GFP against multiple prostate cancer cell lines. Additionally, pre-treatment of MAT-LyLu prostate cancer cells with purified SAC-Par-4-GFP significantly delayed the onset of tumor in a syngeneic rat prostate cancer model. Taken altogether, we proclaim that plant made SAC-Par-4 may become a useful alternate therapy for effectively alleviating cancer in the new era.

  4. Plant-derived pectin nanocoatings to prevent inflammatory cellular response of osteoblasts following Porphyromonas gingivalis infection

    Science.gov (United States)

    Meresta, Anna; Folkert, Justyna; Gaber, Timo; Miksch, Korneliusz; Buttgereit, Frank; Detert, Jacqueline; Pischon, Nicole; Gurzawska, Katarzyna

    2017-01-01

    Background Bioengineered plant-derived Rhamnogalacturonan-Is (RG-Is) from pectins are potential candidates for surface nanocoating of medical devices. It has recently been reported that RG-I nanocoatings may prevent bacterial infection and improve the biocompatibility of implants. The aim of the study was to evaluate in vitro impact of bioengineered RG-I nanocoatings on osteogenic capacity and proinflammatory cytokine response of murine osteoblasts following Porphyromonas gingivalis infection. Methods Murine MC3T3-E1 osteoblasts and isolated primary calvarial osteoblasts from C57BL/6J (B6J osteoblasts) mice were infected with P. gingivalis and incubated on tissue culture polystyrene plates with or without nanocoatings of unmodified RG-Is isolated from potato pulps (PU) or dearabinanated RG-Is (PA). To investigate a behavior of infected osteoblasts cultured on RG-Is cell morphology, proliferation, metabolic activity, mineralization and osteogenic and pro-inflammatory gene expression were examined. Results Following P. gingivalis infection, PA, but not PU, significantly promoted MC3T3-E1 and BJ6 osteoblasts proliferation, metabolic activity, and calcium deposition. Moreover, Il-1b, Il-6, TNF-α, and Rankl gene expressions were downregulated in cells cultured on PU and to a higher extent on PA as compared to the corresponding control, whereas Runx, Alpl, Col1a1, and Bglap gene expressions were upregulated vice versa. Conclusion Our data clearly showed that pectin RG-Is nanocoating with high content of galactan (PA) reduces the osteoblastic response to P. gingivalis infection in vitro and may, therefore, reduce a risk of inflammation especially in immunocompromised patients with rheumatoid or periodontal disorders. PMID:28138240

  5. Preventative and Curative Effects of Several Plant Derived Agents Against Powdery Mildew Disease of Okra

    Directory of Open Access Journals (Sweden)

    Moustafa Hemdan Ahmed MOHARAM

    2012-08-01

    Full Text Available The preventative and curative effects of some plant derived agents based on plant extracts or essential oils were studied at different concentrations against Erysiphe cichoracearum DC. ex Merat, the causal pathogen of okra powdery mildew by the detached leaf-disk and potted plants bioassays. Through detached leaf-disk assay, the highest mean preventative effect (97.74% was recorded by neem seed oil followed by jojoba oil (89.82% and extract of Rynoutria sachalinensis (82.77%. Neem seed oil at 1% was the most effective agent followed by jojoba oil and extract of R. sachalinensis at 1.5% and 2%, respectively, where they suppressed E. cichoracearum completely. Potted plants assay revealed that neem seed oil, jojoba oil and extract of R. sachalinensis as well as the fungicide (active ingredient dinocap showed higher preventative efficacy at all leaf olds treated after 7 and 14 days of inoculation as compared with extracts of henna and garlic. Moreover, the preventative efficacy partly remained apparent after 14 days of inoculation at all leaf olds tested. In field trials through 2010 and 2011 growing seasons, when the first symptoms of powdery mildew appeared naturally, 1.5% jojoba oil, 2% extract of R. sachalinensis and 1% neem seed oil were sprayed individually twice on grown plants to evaluate their efficacy on controlling powdery mildew, growth and yield of okra. Resulted showed that neem seed oil was the most effective agent and highly decreased the disease severity to 29.92%, recorded the highly curative effect (68.15% and also improved plant growth and pods yield.

  6. Hormonal action of plant derived and anthropogenic non-steroidal estrogenic compounds: phytoestrogens and xenoestrogens.

    Science.gov (United States)

    Lóránd, T; Vigh, E; Garai, J

    2010-01-01

    Herbivorous and omnivorous vertebrates have evolved in the presence of a variety of phytoestrogens, i.e., plant-derived compounds that can mimic, modulate or disrupt the actions of endogenous estrogens. Since the discovery of the estrus-inducing effects of some plant products in 1926, considerable effort has been devoted to the isolation and structural and pharmacological characterization of phytoestrogens. Recently, agricultural and industrial pollution has added anthropogenic estrogenic compounds to the list of environmental estrogens. Unlike phytoestrogens, these xenoestrogens tend to accumulate and persist in adipose tissue for decades and may cause long-lasting, adverse endocrine effects. Here we review the endocrine effects of known phytoestrogens and xenoestrogens with special emphasis on molecular structure-activity relationships. Phytoestrogens include flavonoids, isoflavonoids, chalcons, coumestans, stilbenes, lignans, ginsenosides and other saponins, as well as the recently discovered tetrahydrofurandiols. Fungal estrogenic compounds may enter the food chain via infested crops. Since some phytoestrogens have been shown to display organ-specific actions, pharmaceutical estrogen analogues with similar properties (selective estrogen receptor modulators, SERMs) are also discussed. Xenoestrogens include dichlorodiphenyltrichloroethane (DDT) and its metabolites, bisphenols, alkylphenols, dichlorophenols, methoxychlor, chlordecone, polychlorinated benzol derivatives (PCBs), and dioxins. While most of these compounds act through estrogen receptors alpha and beta, some of their effects may be mediated by other nuclear or membrane-bound receptors or receptor-independent mechanisms. Some might also interfere with the production and metabolism of ovarian estrogens. Better understanding of the molecular pharmacology of phyto- and xenoestrogens may result in the development of novel compounds with therapeutic utility and improved environmental protection.

  7. Plant-derived anticancer agents: a promising treatment for bone metastasis

    Science.gov (United States)

    Juárez, Patricia

    2014-01-01

    Bone metastasis is a very frequent complication of advanced cancer, and it remains an incurable disease. Current therapies that have been approved for the treatment of bone metastases delay the occurrence of skeletal-related events and can extend the patient's lifespan by a few years. However, they will not cure or cause the regression of established bone metastases, and new side effects are emerging after prolonged treatment. Thus, new therapies are severely needed. There are compelling evidences from in vitro and in vivo preclinical studies that support the use of compounds derived from plants to treat several forms of cancers including bone metastasis. More than 25% of the drugs used during the past 20 years were directly derived from plants, whereas another 25% are chemically altered natural products. Still, only 5–15% of the ∼250 000 higher plants have ever been investigated for bioactive compounds. There is a growing interest for the study of anticancer drugs with relatively low side effects that target specific key signaling pathways that control the establishment and progression of the cancer metastasis. Therefore, further studies are needed to identify new natural compounds with high efficiency in cancer prevention and treatment. Extensive reviews about plant-derived agents and their use in cancer have been published, but none when it comes to the treatment of bone metastases. Only a few of these compounds have been evaluated for the treatment of bone metastasis; here we describe some of the most prominent ones that are having the potential to reach the clinic soon.

  8. Impressions from the 3rd Nordcode Seminar & Workshop

    DEFF Research Database (Denmark)

    Lenau, Torben Anker; Boelskifte, Per; Hansen, Claus Thorp

    2005-01-01

    This paper summarises the purpose and contents of the 3rd Nordcode Seminar and Workshop. First, the workshop assignments are described. Second, the paper briefly presents the topics of the keynote speeches and all presentations of the working papers that took place in the seminar....

  9. 2015 Cross-Domain Deterrence Seminar Summary Report

    Energy Technology Data Exchange (ETDEWEB)

    Juarez, A. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2016-01-11

    Lawrence Livermore National Laboratory (LLNL) hosted the 2nd Annual Cross-Domain Deterrence Seminar on November 17th, 2015 in Livermore, CA. The seminar was sponsored by LLNL’s Center for Global Security Research (CGSR), National Security Office (NSO), and Global Security program. This summary covers the seminar’s panels and subsequent discussions.

  10. Total Quality Management (TQM) Awareness Seminar. Revision 8

    Science.gov (United States)

    1990-04-18

    TOTAL QUALITY MANAGEMENT (TQM) Awareness Seminar 0 Copyright 1990, BoozAllen & Hamilton Inc. PREPARED FOR...additional TOM training and Identify potential sources for TOM training. Total Quality Management ii1 TOTAL QUALITY MANAGEMENT (TQM) AWARENESS SEMINAR I...DOD Path to Total Quality Management 11. UNDERSTANDING TOTAL QUALITY MANAGEMENT : THE TQM IMPERATIVE " Exercise: Bead Box * History of

  11. China-Spain Investment & Trade Seminar Held in Barcelona

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    @@ On April 24,the China-Spain Investment & Trade Seminar was jointly held in Barcelona,Spain.As the first event of the Chinese Products Promotion Week (Europe),the seminar aims to help the Chinese export enterprises and local governments learn about relevant laws and regulations and product quality standards of the EU.

  12. Proceedings of the Twenty Second Nordic Seminar on Computational Mechanics

    DEFF Research Database (Denmark)

    This book contains the proceedings of the Twenty Second Nordic Seminar on Computational Mechanics (NSCM22), taking event 22-23 October 2009 at Aalborg University, Denmark. The papers presented at the Optimization Seminar in Honour of Niels Olhoff, held 21 October 2009 at Aalborg University, Denmark...

  13. Integrating Webinar and Blogging Technologies into Chemistry Seminar

    Science.gov (United States)

    Hamstra, Dan; Kemsley, Jyllian N.; Murray, Desmond H.; Randall, David W.

    2011-01-01

    We report successfully integrating webinar and blogging into an undergraduate chemistry and biochemistry seminar course. Commercial collaboration software linked speaker-operated slides with two-way voice and video effectively connecting the audience and presenter from different states. Student responses to the technology and seminar content were…

  14. 2016 Electrochemistry Gordon Research Conference and Gordon Research Seminar

    Science.gov (United States)

    2016-02-23

    2016 Electrochemistry Gordon Research Conference & Gordon Research Seminar Operational Summary The Gordon Research Conference (GRC) and Gordon...Research Seminar (GRS) on Electrochemistry were held at the Ventura Beach Marriott in Ventura, California from January 9-15, 2016. The meeting covered...TO THE ABOVE ADDRESS. Gordon Research Conferences, Inc. 512 Liberty Lane West Kingston, RI 02892 -1502 ABSTRACT Final Report: 2016 Electrochemistry

  15. Organizing a Campus Seminar on Careers in Entertainment.

    Science.gov (United States)

    Walt Disney Productions, Anaheim, CA.

    Developed by Walt Disney Productions as part of a project granted by the Career Education Program of the Office of Education, this handbook is designed to help college and university fine arts departments in planning and carrying out an on-campus seminar on careers in entertainment. Sections include Why Hold a Seminar on Careers in Entertainment?,…

  16. Correct and efficient accelerator programming (Dagstuhl Seminar 13142)

    NARCIS (Netherlands)

    Cohen, Albert; Donaldson, Alistair F.; Huisman, Marieke; Katoen, Joost P.

    2013-01-01

    This report documents the program and the outcomes of Dagstuhl Seminar 13142 “Correct and Efficient Accelerator Programming”. The aim of this Dagstuhl seminar was to bring together researchers from various sub-disciplines of computer science to brainstorm and discuss the theoretical foundations, des

  17. Correct and Efficient Accelerator Programming (Dagstuhl Seminar 13142)

    NARCIS (Netherlands)

    Cohen, A.; Donaldson, A.F.; Huisman, Marieke; Katoen, Joost P.

    2013-01-01

    This report documents the program and the outcomes of Dagstuhl Seminar 13142 “Correct and Efficient Accelerator Programming‿. The aim of this Dagstuhl seminar was to bring together researchers from various sub-disciplines of computer science to brainstorm and discuss the the- oretical foundations, d

  18. Improving Higher Education in Developing Countries. EDI Seminar Series.

    Science.gov (United States)

    Ransom, Angela; And Others

    This volume is the result of a policy seminar on Improvement and Innovation in Higher Education in Developing Countries, organized by the Economic Development Institute and the Population and Human Resources Department of the World Bank in collaboration with the Institute of Strategic and International Studies of Malaysia. The seminar was held in…

  19. CAFIU Delegation at "nderstanding Myanmar" International Seminar

    Institute of Scientific and Technical Information of China (English)

    YaoJianguo

    2004-01-01

    The International Seminar on "Understanding Myanmar" was held in Yangon by Myanmar Institute of Strategic and International Studies during January 27-30. More than 40 representatives from 17 countries attended the seminar. They are UN representatives in Myanmar and experts, scholars,

  20. Having a Graduate Seminar "With" Rather Than "From"

    Science.gov (United States)

    Morris, William E.

    1975-01-01

    The educational objectives and techniques for the graduate seminar are outlined and illustrated with material from a successful seminar on The World of John Donne. Included is discussion of selecting an appropriate topic, use of guest lecturers, students working as a team, and the teacher's role. Emphasis is on shared research. (JT)

  1. Interaction and Collective Movement Processing : Report from Dagstuhl Seminar 14132

    NARCIS (Netherlands)

    2014-01-01

    This report documents the program and the outcomes of Dagstuhl Seminar 14132 “Interaction and Collective Movement Processing”. This seminar brought together a group of 30 scientists with varied backgrounds, but with a shared interest in computations involved in the processing of moving entity data,

  2. Nordic seminar on biomass gasification and combustion

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1993-12-31

    The report comprises a collection of papers from a seminar arranged as a part of the Nordic Energy Research Program. The aim of this program is to strengthen the basic competence in the energy field at universities and research organizations in the Nordic countries. In the program 1991-1994 six areas are selected for cooperation such as energy and society, solid fuels, district heating, petroleum technology, bioenergy and environment, and fuel cells. The topics deal both with biomass combustion and gasification, and combustion of municipal solid waste (MSW) and refuse derived fuel (RDF). A number of 11 papers are prepared. 97 refs., 91 figs., 11 tabs.

  3. Fuel Cell Seminar, 1992: Program and abstracts

    Energy Technology Data Exchange (ETDEWEB)

    1992-12-31

    This year`s theme, ``Fuel Cells: Realizing the Potential,`` focuses on progress being made toward commercial manufacture and use of fuel cell products. Fuel cell power plants are competing for market share in some applications and demonstrations of market entry power plants are proceeding for additional applications. Development activity on fuel cells for transportation is also increasing; fuel cell products have potential in energy and transportation industries, with very favorable environmental impacts. This Seminar has the purpose of fostering communication by providing a forum for the international community interested in development, application, and business opportunities related fuel cells. Over 190 technical papers are included, the majority being processed for the data base.

  4. Glasses and grains : Poincaré seminar

    CERN Document Server

    Rivasseau, Vincent; Duplantier, Bertrand

    2011-01-01

    This tenth volume in "The Poincare Seminar Series" describes recent developments at one of the most challenging frontiers in statistical physics - the deeply related fields of glassy dynamics, especially near the glass transition, and of the statics and dynamics of granular systems. These fields are marked by a vigorous interchange between experiment, theory, and numerical studies, all of which are well represented by the leading experts who have contributed articles to this volume. These articles are also highly pedagogical, as befits their origin in lectures to a broad scientific a

  5. Efficacy of Plant-Derived and Synthetic Compounds on Clothing as Repellents Against Ixodes scapularis and Amblyomma americanum (Acari: Ixodidae)

    Science.gov (United States)

    2012-01-01

    efÞcacy of the repellent deet against Aedes aegypti . J. Am. Mosq. Control Assoc. 14: 178Ð182. Robbins, P. J., and M. G. Cherniack. 1986. Review of...VECTOR CONTROL , PEST MANAGEMENT, RESISTANCE, REPELLENTS Efficacy of Plant-Derived and Synthetic Compounds on Clothing as Repellents Against Ixodes...4 Division of Vector-BorneDiseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention

  6. Present and future potential of plant-derived products to control arthropods of veterinary and medical significance

    OpenAIRE

    George, David; Finn, Robert; Graham, Kirsty; Sparagano, Olivier

    2014-01-01

    The use of synthetic pesticides and repellents to target pests of veterinary and medical significance is becoming increasingly problematic. One alternative approach employs the bioactive attributes of plant-derived products (PDPs). These are particularly attractive on the grounds of low mammalian toxicity, short environmental persistence and complex chemistries that should limit development of pest resistance against them. \\ud \\ud Several pesticides and repellents based on PDPs are already av...

  7. Effects of phytoestrogens and other plant-derived compounds on mesenchymal stem cells, bone maintenance and regeneration.

    Science.gov (United States)

    Schilling, Tatjana; Ebert, Regina; Raaijmakers, Nadja; Schütze, Norbert; Jakob, Franz

    2014-01-01

    Phytoestrogens and other plant-derived compounds and extracts have been developed for the treatment of menopause-related complaints and disorders, e.g. hot flushes and osteoporosis. Since estrogens have been discussed to enhance the risk for hormone-sensitive cancers, research activities try to find alternatives. Phytoestrogens like genistein and resveratrol as well as other plant-derived compounds are capable of substituting for estrogens to some extent. Their effects on mesenchymal stem cells and the tissues derived therefrom have been investigated in vitro and in preclinical settings. Besides their well-known estrogenic, i.e. mainly antiresorptive effects on bone via estrogen receptor (ER) signalling, they also directly or indirectly affect osteogenic and adipogenic pathways. As a novel mechanism, phytoestrogens and plant-derived saponins and flavonoids like kaempferol and xanthohumol have been described to reciprocally affect the osteogenic versus the adipogenic differentiation pathway. Both, ER-mediated and other pathways mediate a shift towards osteogenesis by inhibiting PPARγ and C/EBPα, the key adipogenic transcription factors (TFs), while stimulating the key osteogenic TFs Runx2 and Sp7. Besides ER signalling, the broad spectrum of molecular mechanisms supporting osteogenesis comprises the modulation of PPARγ, Wnt/β-catenin, and Sirt1 signalling, which inversely influence the transcription or transactivation of osteogenic versus adipogenic TFs. Preventing the age- and hormone deficiency-related shift towards adipogenesis without provoking adverse estrogenic effects represents a very promising strategy for treating bone loss and other metabolic diseases beyond bone. Research on plant-derived compounds will have to be pursued in vitro as well as in preclinical studies and controlled clinical trials in humans are urgently needed. This article is part of a Special Issue entitled 'Phytoestrogens'.

  8. Rapid inactivation of Salmonella Enteritidis on shell eggs by plant-derived antimicrobials.

    Science.gov (United States)

    Upadhyaya, Indu; Upadhyay, Abhinav; Kollanoor-Johny, Anup; Baskaran, Sangeetha Ananda; Mooyottu, Shankumar; Darre, Michael J; Venkitanarayanan, Kumar

    2013-12-01

    Salmonella Enteritidis is a common foodborne pathogen transmitted to humans largely by consumption of contaminated eggs. The external surface of eggs becomes contaminated with Salmonella Enteritidis from various sources on farms, the main sources being hens' droppings and contaminated litter. Therefore, effective egg surface disinfection is critical to reduce pathogens on eggs and potentially control egg-borne disease outbreaks. This study investigated the efficacy of GRAS (generally recognized as safe) status, plant-derived antimicrobials (PDA), namely trans-cinnamaldehyde (TC), carvacrol (CR), and eugenol (EUG), as an antimicrobial wash for rapidly killing Salmonella Enteritidis on shell eggs in the presence or absence of chicken droppings. White-shelled eggs inoculated with a 5-strain mixture of nalidixic acid (NA) resistant Salmonella Enteritidis (8.0 log cfu/mL) were washed in sterile deionized water containing each PDA (0.0, 0.25, 0.5, or 0.75%) or chlorine (200 mg/kg) at 32 or 42°C for 30 s, 3 min, or 5 min. Approximately 6.0 log cfu/mL of Salmonella Enteritidis was recovered from inoculated and unwashed eggs. The wash water control and chlorine control decreased Salmonella Enteritidis on eggs by only 2.0 log cfu/mL even after washing for 5 min. The PDA were highly effective in killing Salmonella Enteritidis on eggs compared with controls (P Salmonella Enteritidis to undetectable levels as rapidly as within 30 s of washing, whereas TC (0.75%) completely inactivated Salmonella Enteritidis on eggs washed at 42°C for 30 s (P Salmonella Enteritidis was detected in any PDA or chlorine wash solution; however, substantial pathogen populations (~4.0 log cfu/mL) survived in the antibacterial-free control wash water (P Salmonella Enteritidis on eggs to undetectable levels in the presence of 3% chicken droppings at 32°C (P Salmonella Enteritidis on shell eggs. Sensory and quality studies of PDA-washed eggs need to be conducted before recommending their use.

  9. Plant-derived pectin nanocoatings to prevent inflammatory cellular response of osteoblasts following Porphyromonas gingivalis infection

    Directory of Open Access Journals (Sweden)

    Meresta A

    2017-01-01

    Full Text Available Anna Meresta,1 Justyna Folkert,1 Timo Gaber,2 Korneliusz Miksch,1 Frank Buttgereit,2 Jacqueline Detert,2 Nicole Pischon,3,* Katarzyna Gurzawska3,4,* 1Environmental Biotechnology Department, Faculty of Power and Environmental, Silesian University of Technology, Gliwice, Poland; 2Department of Rheumatology and Clinical Immunology, 3Department of Periodontology, Charité University Medicine, Berlin, Germany; 4Oral Surgery Department, The School of Dentistry, University of Birmingham, Birmingham, UK *These authors contributed equally to this work Background: Bioengineered plant-derived Rhamnogalacturonan-Is (RG-Is from pectins are potential candidates for surface nanocoating of medical devices. It has recently been reported that RG-I nanocoatings may prevent bacterial infection and improve the biocompatibility of implants. The aim of the study was to evaluate in vitro impact of bioengineered RG-I nanocoatings on osteogenic capacity and proinflammatory cytokine response of murine osteoblasts following Porphyromonas gingivalis infection.Methods: Murine MC3T3-E1 osteoblasts and isolated primary calvarial osteoblasts from C57BL/6J (B6J osteoblasts mice were infected with P. gingivalis and incubated on tissue culture polystyrene plates with or without nanocoatings of unmodified RG-Is isolated from potato pulps (PU or dearabinanated RG-Is (PA. To investigate a behavior of infected osteoblasts cultured on RG-Is cell morphology, proliferation, metabolic activity, mineralization and osteogenic and pro-inflammatory gene expression were examined.Results: Following P. gingivalis infection, PA, but not PU, significantly promoted MC3T3-E1 and BJ6 osteoblasts proliferation, metabolic activity, and calcium deposition. Moreover, Il-1b, Il-6, TNF-α, and Rankl gene expressions were downregulated in cells cultured on PU and to a higher extent on PA as compared to the corresponding control, whereas Runx, Alpl, Col1a1, and Bglap gene expressions were upregulated vice

  10. Evaluation of the anti-Listeria potentials of some plant-derived triterpenes.

    Science.gov (United States)

    Penduka, Dambudzo; Mosa, Rebamang; Simelane, Mthokozisi; Basson, Albert; Okoh, Anthony; Opoku, Andy

    2014-07-23

    Listeriosis is a fatal disease caused by pathogenic Listeria bacteria and it is most prevalent in immune-compromised individuals. The increase in numbers of immune-compromised individuals against a background of Listeria antibiotic resistance, limits listeriosis treatment options. This therefore calls for research into substitute treatments, of which, medicinal plants derived compounds offer a viable alternative. The broth microdilution assay was used to determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of three plant triterpenes namely 3β-hydroxylanosta-9,24-dien-21-oic acid, methyl-3β-hydroxylanosta-9,24-dien-21-oate and 3β-acetylursolic acid, against Listeria monocytogenes, Listeria ivanovii and Listeria grayi species. The chequerboard method was used to assess the interactions between the triterpenes and conventional antibiotics: ampicillin, neomycin, gentamicin and penicillin G. The lactate dehydrogenase membrane damage method was used to assess the triterpenes' membrane damaging potentials against the Listeria bacteria. The triterpenes' MIC values were found to range from 0.185 to 1.67 mg/ml while, the MBC determination assay results revealed that the test triterpenes were bacteriostatic against the Listeria bacteria. The interactions involving 3β-hydroxylanosta-9,24-dien-21-oic acid were mainly additive with ampicillin and synergistic with neomycin, gentamicin and penicillin G. The interactions involving methyl-3β-hydroxylanosta-9,24-dien-21-oate were mainly antagonistic with ampicillin, indifferent with neomycin, ranging from synergistic to indifference with gentamicin and synergistic with penicillin G. The interactions involving 3β-acetylursolic acid were mainly indifferent with ampicillin, synergistic with neomycin and gentamicin while ranging between synergistic and additive with penicillin G. The low levels of cytosolic lactate dehydrogenase released from the cells treated with 4× MIC concentration

  11. Seminar on Financing Education: The Budgetary Process Under Pressure. Proceedings of a Seminar (Ottawa, Ontario, March 1-2, 1976).

    Science.gov (United States)

    Canadian Teachers' Federation, Ottawa (Ontario).

    The purpose of this seminar was to give members of the Canadian Teachers' Federation a better understanding of the educational budgetary process. The proceedings of the seminar included welcoming remarks by Russell D. Mosher followed by two addresses--"The Political Context of Budgeting" by Dr. Peter Atherton and "Resource…

  12. Programme of Seminars September to December 2003

    CERN Multimedia

    2003-01-01

    Dates Jours/ Days Places Disponibles*/ Places Available* Séminaires bilingues/Bilingual seminars Gestion de la qualité/Quality Management 10, 11, 12 November 3 oui Managing a CERN unit - to be a Manager/ Gérer une unité au CERN - Etre Manager (Module 3) 11, 12 November 2 non Gestion des risques /Risk Management 11, 12 December 2 oui Seminars in English Communicating effectively in your team 19, 20 November 2 yes Performance Appraisal Training MAPS 26, 27, 28 November 3 yes Managing by Project 3, 4 December 3 no Making Presentations 1, 2 December & 12 January 2004 3 yes Performance Appraisal Training MAPS 8, 9, 10 December 3 no Séminaires en Français Formation à l'entretien d'appréciation MAPS 26, 27, 28 novembre 3 non Formation à l'entretien d'appréciation MAPS 8, 9, 10 décembre 3 oui Animer ou participer à une ré...

  13. Wind Turbine Tribology Seminar - A Recap

    Energy Technology Data Exchange (ETDEWEB)

    Errichello, R.; Sheng, S.; Keller, J.; Greco, A.

    2012-02-01

    Tribology is the science and engineering of interacting surfaces in relative motion. It includes the study and application of the principles of friction, lubrication, and wear. It is an important phenomenon that not only impacts the design and operation of wind turbine gearboxes, but also their subsequent maintenance requirements and overall reliability. With the major growth and increasing dependency on renewable energy, mechanical reliability is an extremely important issue. The Wind Turbine Tribology Seminar was convened to explore the state-of-the-art in wind turbine tribology and lubricant technologies, raise industry awareness of a very complex topic, present the science behind each technology, and identify possible R&D areas. To understand the background of work that had already been accomplished, and to consolidate some level of collective understanding of tribology by acknowledged experts, the National Renewable Energy Laboratory (NREL), Argonne National Laboratory (ANL), and the U.S. Department of Energy (DOE) hosted a wind turbine tribology seminar. It was held at the Renaissance Boulder Flatiron Hotel in Broomfield, Colorado on November 15-17, 2011. This report is a summary of the content and conclusions. The presentations given at the meeting can be downloaded. Interested readers who were not at the meeting may wish to consult the detailed publications listed in the bibliography section, obtain the cited articles in the public domain, or contact the authors directly.

  14. Geneva University - Next Particle Physics Seminars

    CERN Multimedia

    Université de Genève

    2010-01-01

    GENEVA UNIVERSITY École de physique Département de physique nucléaire et corspusculaire 24, quai Ernest-Ansermet 1211 GENEVA 4 Tel. (022) 379 62 73 Fax (022) 379 69 92 Wednesday 17 November 2010 PARTICLE PHYSICS SEMINAR at 17-00 hrs – Stückelberg Auditorium Results on CP-Violation in The B_s and B_d systems at the Tevatron Dr. Iain Bertram, Lancaster Results will be presented from the investigation of CP-violation in B mesons at the Tevatron. The evidence for an anomalous likes-sign dimuon charge asymmetry will be presented, along with the latest results on CP violation in the Bs -> J/Psi Phi system. The implications of these results and the possibility of confirming them in the future will also be discussed. Information : http://dpnc.unige.ch/seminaire/annonce.html Organizer : G. Pasztor Wednesday 1st December 2010 PARTICLE PHYSICS SEMINAR at 17-00 hrs – Stückelberg Auditorium PAMELA - A COSMIC RAY OBSERVATO...

  15. Seminar on Detectors and measurements techniques

    Energy Technology Data Exchange (ETDEWEB)

    Holm, E. (ed.) [Risoe National Lab., Roskilde (Denmark)

    2002-07-01

    A Nordic Seminar on detectors and radionuclide measurement techniques was held in Lund, Sweden, May 3-4, 2001. The objective was to highlight recent progress and problems for techniques to study environmental radioactivity. It covered the aspect of detector sample geometry's and methods for evaluation of gamma gamma pulse height distributions. Within the field of alpha-spectrometric techniques gridded ionisation chambers, semiconductor detectors and a general description for analysis of alpha-particle-spectra were presented. Recent development in mass spectrometric techniques, AMS (Accelerator Mass Spectrometry) and ICPMS (Inductively Coupled Plasma mass Spectrometry) for long-lived radionuclides was described. Principles for analysis of beta particle emitters, especially by liquid scintillation were presented. The seminar also covered radiochemistry such advantages and disadvantages between ion exchange, solvent extraction and extraction chromatography. The use of controlled laboratory conditions for discerning the dynamics of accumulation in organisms was demonstrated. Other techniques such as neutron activation were also shown to be useful analytical tool for certain long-lived radionuclides. The results of the intercalibration exercises within the Nordic countries showed the importance of such analytical quality control. (au)

  16. DESAIN MODUL CONTENT MANAGEMENT SYSTEM UNTUK APLIKASI SISTEM INFORMASI SEMINAR ILMIAH

    OpenAIRE

    Ilham, Amil Ahmad

    2014-01-01

    Pelaksanaan seminar dan konferensi yang semakin meningkat dari tahun ke tahun membuat panitia pelaksananya sering kesulitan dalam menyebarkan informasi seminar. Website menjadi salah satu alternatif penyebaran informasi yang cepat dan efektif, namun dibutuhkan pemahaman web programming terlebih dahulu untuk membangun sebuah website. Karena keterbatasan tersebut, para pelaksana seminar biasanya menggunakan jasa webmaster untuk membangun sistem informasi seminar. Untuk mengatasi masalah terseb...

  17. Role of seminars in educational process of secondary schools and high schools.

    Directory of Open Access Journals (Sweden)

    Yefremov S.V.

    2011-03-01

    Full Text Available The seminar and classification of seminars in secondary school were considered. It was analysed the groups of the seminars, types of the seminars by means of activity, by deductive aim. The seminar is the form of independent scientific and research work which enables the reception of scientific and informative skills during preparation for seminar. Choice of small quantity of a material for a seminar gives possibility for pupils to take the floor with his report, generalizing and proving his point of view and developing logical thinking.

  18. Skin Antiageing and Systemic Redox Effects of Supplementation with Marine Collagen Peptides and Plant-Derived Antioxidants: A Single-Blind Case-Control Clinical Study.

    Science.gov (United States)

    De Luca, Chiara; Mikhal'chik, Elena V; Suprun, Maxim V; Papacharalambous, Michael; Truhanov, Arseniy I; Korkina, Liudmila G

    2016-01-01

    Recently, development and research of nutraceuticals based on marine collagen peptides (MCPs) have been growing due to their high homology with human collagens, safety, bioavailability through gut, and numerous bioactivities. The major concern regarding safety of MCPs intake relates to increased risk of oxidative stress connected with collagen synthesis (likewise in fibrosis) and to ROS production by MCPs-stimulated phagocytes. In this clinical-laboratory study, fish skin MCPs combined with plant-derived skin-targeting antioxidants (AO) (coenzyme Q10 + grape-skin extract + luteolin + selenium) were administered to volunteers (n = 41). Skin properties (moisture, elasticity, sebum production, and biological age) and ultrasonic markers (epidermal/dermal thickness and acoustic density) were measured thrice (2 months before treatment and before and after cessation of 2-month oral intake). The supplementation remarkably improved skin elasticity, sebum production, and dermal ultrasonic markers. Metabolic data showed significant increase of plasma hydroxyproline and ATP storage in erythrocytes. Redox parameters, GSH/coenzyme Q10 content, and GPx/GST activities were unchanged, while NO and MDA were moderately increased within, however, normal range of values. Conclusions. A combination of MCPs with skin-targeting AOs could be effective and safe supplement to improve skin properties without risk of oxidative damage.

  19. Skin Antiageing and Systemic Redox Effects of Supplementation with Marine Collagen Peptides and Plant-Derived Antioxidants: A Single-Blind Case-Control Clinical Study

    Directory of Open Access Journals (Sweden)

    Chiara De Luca

    2016-01-01

    Full Text Available Recently, development and research of nutraceuticals based on marine collagen peptides (MCPs have been growing due to their high homology with human collagens, safety, bioavailability through gut, and numerous bioactivities. The major concern regarding safety of MCPs intake relates to increased risk of oxidative stress connected with collagen synthesis (likewise in fibrosis and to ROS production by MCPs-stimulated phagocytes. In this clinical-laboratory study, fish skin MCPs combined with plant-derived skin-targeting antioxidants (AO (coenzyme Q10 + grape-skin extract + luteolin + selenium were administered to volunteers (n=41. Skin properties (moisture, elasticity, sebum production, and biological age and ultrasonic markers (epidermal/dermal thickness and acoustic density were measured thrice (2 months before treatment and before and after cessation of 2-month oral intake. The supplementation remarkably improved skin elasticity, sebum production, and dermal ultrasonic markers. Metabolic data showed significant increase of plasma hydroxyproline and ATP storage in erythrocytes. Redox parameters, GSH/coenzyme Q10 content, and GPx/GST activities were unchanged, while NO and MDA were moderately increased within, however, normal range of values. Conclusions. A combination of MCPs with skin-targeting AOs could be effective and safe supplement to improve skin properties without risk of oxidative damage.

  20. 17th Poincaré Seminar 2013

    CERN Document Server

    Duplantier, Bertrand; Raimond, Jean-Michel; Rivasseau, Vincent

    2016-01-01

    This fourteenth volume in the Poincaré Seminar Series is devoted to Niels Bohr, his foundational contributions to understanding atomic structure and quantum theory and their continuing importance today. This book contains the following chapters: - Tomas Bohr, Keeping Things Open; - Olivier Darrigol, Bohr's Trilogy of 1913; -John Heilbron, The Mind that Created the Bohr Atom; - Serge Haroche & Jean-Michel Raimond, Bohr's Legacy in Cavity QED; - Alain Aspect, From Einstein, Bohr, Schrödinger to Bell and Feynman: a New Quantum Revolution?; - Antoine Browaeys, Interacting Cold Rydberg Atoms: A Toy Many-Body System; - Michel Bitbol & Stefano Osnaghi, Bohr´s Complementarity and Kant´s Epistemology. Dating from their origin in lectures to a broad scientific audience these seven chapters are of high educational value. This volume is of general interest to physicists, mathematicians and historians.

  1. 13th New Mexico Analysis Seminar

    CERN Document Server

    Marcantognini, Stefania; Stokolos, Alexander; Urbina, Wilfredo

    2016-01-01

    Covering a range of subjects from operator theory and classical harmonic analysis to Banach space theory, this book contains survey and expository articles by leading experts in their corresponding fields, and features fully-refereed, high-quality papers exploring new results and trends in spectral theory, mathematical physics, geometric function theory, and partial differential equations. Graduate students and researchers in analysis will find inspiration in the articles collected in this volume, which emphasize the remarkable connections between harmonic analysis and operator theory. Another shared research interest of the contributors of this volume lies in the area of applied harmonic analysis, where a new notion called chromatic derivatives has recently been introduced in communication engineering. The material for this volume is based on the 13th New Mexico Analysis Seminar held at the University of New Mexico, April 3-4, 2014 and on several special sections of the Western Spring Sectional Meeting at th...

  2. Seminar on building codes and standards

    Energy Technology Data Exchange (ETDEWEB)

    1980-01-01

    A seminar was conducted for state building code officials and state energy officials to discuss the following: status of the states regulatory activities for energy conservation standards for buildings; the development, administration, and enforcement processes for energy conservation standards affecting new construction; lighting and thermal standards for existing buildings; status of the development and implementation of the Title III Program, Building Energy Performance Standards (BEPS); and current status of the State Energy Conservation Program. The welcoming address was given by John Wenning and the keynote address was delivered by John Millhone. Four papers presented were: Building Energy Performance Standards Development, James Binkley; Lighting Standards in Existing Buildings, Dorothy Cronheim; Implementation of BEPS, Archie Twitchell; Sanctions for Building Energy Performance Standards, Sue Sicherman.

  3. Different effects of plant-derived dissolved organic matter (DOM) and urea on the priming of soil organic carbon.

    Science.gov (United States)

    Qiu, Qingyan; Wu, Lanfang; Ouyang, Zhu; Li, Binbin; Xu, Yanyan

    2016-03-01

    Soil organic carbon (SOC) mineralization is important for the regulation of the global climate and soil fertility. Decomposition of SOC may be significantly affected by the supply of plant-derived labile carbon (C). To investigate the impact of plant-derived dissolved organic matter (DOM) and urea (N) additions on the decomposition of native SOC as well as to elucidate the underlying mechanisms of priming effects (PEs), a batch of incubation experiments was conducted for 250 days by application of (13)C-labeled plant-derived DOM and urea to soils. The direction of PE induced by the addition of DOM was different from the addition of N, i.e. it switched from negative to positive in DOM-amended soils, whereas in the N-treated soil it switched from positive to negative. Adding DOM alone was favorable for soil C sequestration (59 ± 5 mg C per kg soil), whereas adding N alone or together with DOM accelerated the decomposition of native SOC, causing net C losses (-62 ± 4 and -34 ± 31 mg C per kg soil, respectively). These findings indicate that N addition and its interaction with DOM are not favorable for soil C sequestration. Adding DOM alone increased the level of dissolved organic carbon (DOC), but it did not increase the level of soil mineral N. Changes in the ratio of microbial biomass carbon (MBC) to microbial biomass nitrogen (MBN) and microbial metabolic quotient (qCO2) after the addition of DOM and N suggest that a possible shift in the microbial community composition may occur in the present study. Adding DOM with or without N increased the activities of β-glucosidase and urease. Changes in the direction and magnitude of PE were closely related to changes in soil C and N availability. Soil C and N availability might influence the PE through affecting the microbial biomass and extracellular enzyme activity as well as causing a possible shift in the microbial community composition.

  4. Rakvere õpetajate seminar aegade tuules / Ilmar Järg

    Index Scriptorium Estoniae

    Järg, Ilmar

    2007-01-01

    Sel suvel tähistab Rakvere Õpetajate Seminar ja hilisem Rakvere Pedagoogiline Kool, mis suleti 50 aastat tagasi, 95. aastapäeva. Silmapaistvaim Rakveres töötanud õpetajate õpetajatest oli legendaarne koolimees Voldemar Raam

  5. Monterey Strategy Seminar: Day 1: Capabilities Based Planning.

    OpenAIRE

    Russell, James A; Pulsipher, Lashley; Zellen, Barry; Lavoy, Peter R.; Clary, Christopher

    2004-01-01

    Monterey Strategy Seminar: Day 1: Capabilities Based Planning. Day 2: Dissuasion in the U.S. Defense Strategy. Day 3: Global Strike Warfare Naval Postgraduate School Center for Contemporary Conflict (CCC)

  6. Proceedings of the 8. Nordic seminar on radioecology

    Energy Technology Data Exchange (ETDEWEB)

    Ilus, E. [STUK (FI)] (ed.)

    2002-04-01

    This report contains proceedings of the 8th Nordic Seminar on Radioecology held on February 25-28, 2001 in Rovaniemi, Finland. The Seminar was arranged by STUK - Radiation and Nuclear Safety Authority of Finland and supported by the NKS. The Seminar was intended to be a 'final forum' of the four-year NKS radioecology project BOK-2, Radioecological and Environmental Consequences, which was focused on the consequences of releases of man-made radionuclides into the environment. The programme of the Seminar consisted of 3 invited lectures, 31 oral presentations and 22 poster presentations dealing with marine, terrestrial and freshwater radioecology, methods, foodstuffs, models, whole-body counting and doses to man. (au)

  7. Special Issue: Selected Articles from the 1994 NORCHIP Seminar

    DEFF Research Database (Denmark)

    1996-01-01

    This Special Issue of Analog Integrated Circuits and Signal Processing presents extended versions of selected papers from the 12th NORCHIP Seminar which was held November 8-9, 1994, in Gothenburg, Sweden....

  8. Artificial and Computational Intelligence in Games: Integration (Dagstuhl Seminar 15051)

    OpenAIRE

    Lucas, Simon M.; Mateas, Michael; Preuss, Mike; Spronck, Pieter; Togelius, Julian

    2015-01-01

    This report documents Dagstuhl Seminar 15051 "Artificial and Computational Intelligence in Games: Integration". The focus of the seminar was on the computational techniques used to create, enhance, and improve the experiences of humans interacting with and within virtual environments. Different researchers in this field have different goals, including developing and testing new AI methods, creating interesting and believable non-player characters, improving the game production pipeline, study...

  9. Representation, Analysis and Visualization of Moving Objects (Dagstuhl Seminar 12512)

    OpenAIRE

    Gudmundsson, Joachim; Laube, Patrick; Van Loon, Emiel

    2013-01-01

    From December 16 to December 21, 2012, the Dagstuhl Seminar 12512 "Representation, Analysis and Visualization of Moving Objects" was held in Schloss Dagstuhl -- Leibniz Center for Informatics. The major goal of this seminar was to bring together the diverse and fast growing, research community that is involved in developing better computational techniques for spatio-temporal object representation, data mining, and visualization of moving object data. The participants included experts from fie...

  10. High School and Community College Astronomy Research Seminar

    Science.gov (United States)

    Genet, Russell M.; Boyce, Pat; Buchheim, Robert; Collins, Dwight; Freed, Rachel; Harshaw, Richard; Johnson, Jolyon; Kenney, John; Wallen, Vera

    2016-06-01

    For the past decade, Cuesta College has held an Astronomy Research Seminar. Teams of high school and community college students, with guidance from instructors and advanced amateur astronomers, have made astronomical observations, reduced their data, and submitted their research results to appropriate journals. A variety of projects, using modest-aperture telescopes equipped with low-cost instruments, are within reach of motivated students. These include double star astrometry, variable star photometry, and exoplanet transit timing. Advanced scientific knowledge and mastery of sophisticated experimental skills are not required when the students are immersed within a supportive community of practice. The seminar features self-paced, online learning units, an online textbook (the Small Telescope Astronomical Research Handbook), and a supportive website sponsored by the Institute for Student Astronomical Research (www.In4StAR.org). There are no prerequisites for the seminar. This encourages everyone—including underrepresented minorities and persons with disabilities—to participate. Each participant contributes as their time, talents, and experience dictates, thus replicating the modern, professional research team. Our spring 2015 seminar was the largest yet. Volunteer assistant instructors provided local in-person leadership, while the entire seminar met online for PowerPoint presentations on proposed projects and final research results. Some 37 students from eight schools finished the seminar as coauthors of 19 papers published in the January 2016 volume of the Journal of Double Star Observations. Robotic telescopes devoted to student research are coming online at both Concordia University and the Boyce Astronomical Robotic Observatory, as is a central online sever that will provide students with uniform, cost-free reduction and analysis software. The seminar has motivated many of its graduates to pursue careers in science, engineering, and medicine, often with

  11. ORGANIZATIONAL METHODS OF SEMINAR-DISPUTE ON ECONOMICS SPECIALTIES

    Directory of Open Access Journals (Sweden)

    Tatiana ANDREEVA

    2015-12-01

    Full Text Available Actuality. The topic of teaching economic disciplines has always been relevant and useful. The article considers the technique of organization and of the seminar-dispute on economic subjects. In this paper there are also identified criteria for evaluating the participants of the seminar-dispute. Methods of teaching economic disciplines in higher education are held by holding lectures and seminars. The seminar provides an opportunity to determine the degree of independence and responsibility, to rise creativity in every student. The purpose is to disclose the main objectives of the seminar-dispute, which as a result of the preliminary work on the program material, the teacher and students are in a situation of direct active communication during performance of students on topics arising between discussion and generalizations by teacher, bu solving the problem of cognitive, developmental and educational character that imparted methodological and practical skills to students. Methods. Logical and descriptive, monographic, analysis and synthesis. Results. It should be concluded that in preparation for the seminar, students acquire the skills to work with the book, read the analysis, selection of the main and necessary speeches for the report, , and systematizing the selected materials. Students learn to clearly express their thoughts, work out the ability to speak without papers to prove their beliefs, to establish contact with the audience, etc. Accordingly, it is best to choose the topics of the seminar where the student must not only learn certain information, but also find a solution. One of the most popular forms of classes in the framework of methodological approaches to the teaching of economic disciplines is a seminar-dispute.

  12. Plant-Derived Anti-Inflammatory Compounds: Hopes and Disappointments regarding the Translation of Preclinical Knowledge into Clinical Progress

    Directory of Open Access Journals (Sweden)

    Robert Fürst

    2014-01-01

    Full Text Available Many diseases have been described to be associated with inflammatory processes. The currently available anti-inflammatory drug therapy is often not successful or causes intolerable side effects. Thus, new anti-inflammatory substances are still urgently needed. Plants were the first source of remedies in the history of mankind. Since their chemical characterization in the 19th century, herbal bioactive compounds have fueled drug development. Also, nowadays, new plant-derived agents continuously enrich our drug arsenal (e.g., vincristine, galantamine, and artemisinin. The number of new, pharmacologically active herbal ingredients, in particular that of anti-inflammatory compounds, rises continuously. The major obstacle in this field is the translation of preclinical knowledge into evidence-based clinical progress. Human trials of good quality are often missing or, when available, are frequently not suitable to really prove a therapeutical value. This minireview will summarize the current situation of 6 very prominent plant-derived anti-inflammatory compounds: curcumin, colchicine, resveratrol, capsaicin, epigallocatechin-3-gallate (EGCG, and quercetin. We will highlight their clinical potential and/or pinpoint an overestimation. Moreover, we will sum up the planned trials in order to provide insights into the inflammatory disorders that are hypothesized to be beneficially influenced by the compound.

  13. Sulakultuur. d-Fusion seminar Helsingis = The culture of fusion. d-Fusion seminar in Helsinki / Inga Raukas

    Index Scriptorium Estoniae

    Raukas, Inga, 1967-

    2001-01-01

    Kaasaegsete linnakultuuride sulandumine ja hajumine. Seminar ja videonäitus Finlandia Talos 7.-8. juulini 2001. Seminari korraldanud arhitektuuribüroo Ocean North installatsioone ja Töölö jalgpallistaadioni projekt

  14. Sulakultuur. d-Fusion seminar Helsingis = The culture of fusion. d-Fusion seminar in Helsinki / Inga Raukas

    Index Scriptorium Estoniae

    Raukas, Inga, 1967-

    2001-01-01

    Kaasaegsete linnakultuuride sulandumine ja hajumine. Seminar ja videonäitus Finlandia Talos 7.-8. juulini 2001. Seminari korraldanud arhitektuuribüroo Ocean North installatsioone ja Töölö jalgpallistaadioni projekt

  15. Accelerated approach of discovering plant-derived drug leads for treatment of tuberculosis

    CSIR Research Space (South Africa)

    Naidoo, D

    2010-09-01

    Full Text Available and screened for biological activity. the active fractions were analysed by uPLc-toF-dAd- MS for uV, accurate mass and MS-MS fragmentation data to identify the compounds present. By using the data to search the dictionary of natural products, scientists... screening results, only fraction A10 had inhibitory activity against the drug sensitive strain. other fractions were inactive. the uPLc-toF-dAd-MS data generated for the crude extract A1 and the fractions A10 and A11 are shown in Figure 2. Figure 2...

  16. Seminare mit Klinischem Bezug und Integrierte Seminare: Bestandsaufnahme zur Umsetzung der (neuen ÄAppO ["Integrated Seminars" versus "Seminars with Clinical Context" - Analysis of the Effects of the Medical Licensure Act (ÄAppO

    Directory of Open Access Journals (Sweden)

    Ball, Sabine

    2008-08-01

    Full Text Available [english] The new Medical Licensure Act (Approbationsordnung für Ärzte 2002, ÄAppO involves several changes to preclinical education: In particular, the new “seminars with clinical context” and “integrated seminars” stipulated by the ÄAppO are points of discussion. Since there are only a few publications on this topic, it is the target of this article to describe the “new” seminars and to comment on their implementation. We contacted all 36 German medical faculties and, using a semistandardized questionnaire (rate of return: 50%, surveyed them about their implementation and appreciation of these seminars. Thirty-nine percent of medical faculties combine both seminars into one course. In the remaining faculties, there seems to be a close conceptual connection between these seminars, so that the actual difference between the two remains blurred. In many cases, the new seminars are integrated into preexisting seminars and practical training courses. Only two out of three medical faculties seem to have concrete instructions in the curriculum regarding the implementation of these seminars. The integration of clinical content in preclinical education enjoys a high acceptance among students and teaching staff alike. However, there has been criticism that, by fulfilling the concrete legal requirements of the new ÄAppO, students are overburdened in terms of time and content and the faculties’ teaching capacity is overstretched. Nevertheless, we can conclude that the requirements of the ÄAppO concerning implementation of the new seminars are being fulfilled. [german] Die neue Approbationsordnung für Ärzte vom 27.06.2002 brachte auch für den vorklinischen Bereich einige Neuerungen mit sich. So sind insbesondere die nun eingeführten „Seminare mit Klinischem Bezug“ bzw. „Integrierten Seminare“ nach § 2 Abs. 2 zu nennen. Da bisher nur wenige Publikationen zu diesem zentralen Thema des Einbezugs von Klinischem in die Vorklinik

  17. Plant-derived alternative treatments for the aging male: facts and myths.

    Science.gov (United States)

    Wuttke, Wolfgang; Jarry, Hubertus; Seidlova-Wuttke, Dana

    2010-06-01

    Soy- or red clover- derived products containing isoflavones have been amply studied in climacteric and postmenopausal women, and confusing contradicting results have been published. The beneficial effects on climacteric complaints, cholesterol and the development of osteoporosis are marginally at best and there are no uterine and mammary safety studies. In males, however, isoflavones may protect the prostate to make them less prone to develop cancer. Cell biological and animal experimental data support this notion. Clinical data about possible beneficial effects on cholesterol or in the bone are largely missing. Hence, soy or red clover products containing the mild estrogenic isoflavones with a slightly higher affinity to the estrogen receptor of the beta in comparison to the alpha subtype may prove to have some beneficial effects in males.

  18. EDUCATION OF AGRICULTURISTS THROUGH SPECIALIST SEMINARS

    Directory of Open Access Journals (Sweden)

    Kristina Svržnjak

    2006-12-01

    Full Text Available According to the National programme of agriculture and rural areas (2003. it is pointed out that the social-economic development of rural areas is remarkably interfered by their unsuitable educational structure and puts them behind with city inhabitants. It is also pointed out that the offer of programmes for professional development of education and improvement due to specific needs for education of adult rural population (especially farmers is proportionately low. Therefore, general needs for improvement of educational structure of farmers and rural population are extended, especially through the system of permanent professional education and improvement for requirements of family farming and rural population as are specialist seminars at College of Agriculture in Križevci for farmers. Such training colleges have been conducting here since 2004. Until now, 298 trainees have finished such form of education. They were organised in collaboration with 9 agricultural associations. Sex, age and educational structure of trainees as well as average number of people engaged in farming for 213 trainees organized in collaboration with 6 agricultural associations were analysed by this study. They finished training colleges during 2004th and 2005th year. Analysed data was obtained from questionnaire that summaries the most frequent comments and suggestions as the most important guidance for further organisation of such form of education.

  19. Seminar on setting up your own business

    CERN Multimedia

    DSU Department

    2008-01-01

    Organised by the French-Swiss Foundation for Research and Technology (FFRST), in partnership with CERN, and open to all CERN personnel: Friday 7 March 2008, from 9.00 a.m. to 4.00 p.m. in the Globe of Science and Innovation Are you interested in setting up your own business? Have you already taken any steps in that direction? Do you wish to develop a business plan based on your own professional expertise? If so, you are cordially invited to take part in this seminar, at which you will have the opportunity to: hear first-hand accounts from former members of the CERN personnel who have become entrepreneurs and talk about their experience and needs in terms of financial support, find out about the possibilities for obtaining support at the national level (in Switzerland and France) through presentations of the CTI Start-up and OSEO programmes, have discussions with the relevant Swiss and French regional authorities responsible for supporting start-ups in innovative technolog...

  20. Seminar on setting up your own business

    CERN Multimedia

    DSU Department

    2008-01-01

    Organised by the French-Swiss Foundation for Research and Technology (FFRST), in partnership with CERN, and open to all CERN personnel: Friday 7 March 2008, from 9.00 a.m. to 4.00 p.m. in the Globe of Science and Innovation Are you interested in setting up your own business? Have you already taken any steps in that direction? Do you wish to develop a business plan based on your own professional expertise? If so, then you are cordially invited to take part in this seminar at which you will have the opportunity to: hear first-hand accounts from former members of the CERN personnel who have become entrepreneurs and talk about their experience and needs in terms of financial support, find out about the possibilities of obtaining support at national level (in Switzerland and France) through presentations of the CTI Start-up and OSEO programmes, have discussions with the relevant Swiss and French regional authorities responsible for supporting start-ups in innovative technologies...

  1. External Meeting: Geneva University - Particle physics seminar

    CERN Document Server

    Université de Genève

    2011-01-01

    UNIVERSITE DE GENEVE Ecole de physique Département de physique nucléaire et corspusculaire 24, quai Ernest-Ansermet 1211 GENEVE 4 Tél: (022) 379 62 73 Fax: (022) 379 69 92 Wednesday 22 June 2011 PARTICLE PHYSICS SEMINAR at 17.00 hrs – Stückelberg Auditorium Indication of νμ→νe appearance in the T2K experiment Indication de la transition νμ→νe dans l’expérience T2K Par Prof. Alain Blondel - DPNC, Université de Genève The T2K neutrino experiment in Japan has searched for νμ → νe appearance in data taken since the start-up in 2010 till11 March 2011. Six events pass all selection criteria at the far detector situated at 295 km while 1.5±0.3(syst.) would be expected if θ13=0 . This is equivalent to an indication of a non zero value of θ13 at a significance of 2.5σ. This process is particu...

  2. Geneva University: seminar of particle physics

    CERN Multimedia

    Geneva University

    2012-01-01

    GENEVA UNIVERSITY École de physique Département de physique nucléaire et corspusculaire 24, quai Ernest-Ansermet 1211 Genève 4 Tél.: (022) 379 62 73 Fax: (022) 379 69 92 Wednesday 9 May 2012 SEMINAR OF PARTICLE PHYSICS 11h15 - Science III, Auditoire 1S081 30 The Search for the Magnetic Monopole Dr Philippe Mermod - University of Geneva, DPNC It has long been realised that the existence of a magnetic monopole would be sufficient to explain the quantisation of electric charge, and to symmetrise Maxwell's equations. Furthermore, the monopole is an essential ingredient in Grand Unification theories. Primordial monopoles would have been produced in the Early Universe and still be present today, either in cosmic rays or trapped in matter. Monopoles of accessible masses would also be pair-produced at high-energy accelerators. Their remarkable properties can be exploited to devise various means of direct detection. After reviewin...

  3. Report of the European Energy Law Seminar 2013; Verslag European Energy Law Seminar 2013

    Energy Technology Data Exchange (ETDEWEB)

    Hanema, D.M.; Boekholt, H.D.; Mueller, H.K. [Groningen Centre of Energy Law CGEL, Rijksuniversiteit Groningen, Groningen (Netherlands)

    2013-05-15

    In Noordwijk aan Zee, Netherlands, the 26th European Energy Law Seminar was held, May 27-28, 2013. On the first day, the following topics were dealt with: consumer protection and market liberalization in the energy sector, competition and the energy sector, and the European Network Regulation. The second day was devoted to renewable energy and state aid, investments in the infrastructure and its protection, and security of supply. The presentations were given in English. In this article the titles and summaries of the presentations are given in Dutch [Dutch] Op 27 en 28 mei 2013 vond te Noordwijk aan Zee het 26e European Energy Law Seminar plaats. Op de eerste dag werden de volgende onderwerpen besproken: consumentenbescherming en marktliberalisatie binnen de energiesector, mededingingsrecht en de energiesector, en de Europese Netwerk Regulering. Op de tweede dag werd aandacht besteed aan duurzame energiebronnen en staatssteun, investeringen in de infrastructuur en de bescherming hiervan, en leveringszekerheid. De voordrachten hebben allen plaatsgehad in het Engels. In dit artikel wordt per presentatie de titel en een samenvatting van de inhoud in het Nederlands gegeven.

  4. Plant-derived immunomodulators: An insight on their preclinical evaluation and clinical trials

    Directory of Open Access Journals (Sweden)

    Ibrahim eJantan

    2015-08-01

    Full Text Available The phagocyte-microbe interactions in the immune system is a defence mechanism but when excessively or inappropriately deployed can harm host tissues and participate in the development of different non-immune and immune chronic inflammatory diseases such as autoimmune problems, allergies, some rheumatoid disorders, cancers and others. Immunodrugs include organic synthetics, biological agents such as cytokines and antibodies acting on single targets or pathways have been used to treat immune-related diseases but with limited success. Most of immunostimulants and immunosuppressants in clinical use are the cytotoxic drugs which possess serious side effects. There is a growing interest to use herbal medicines as multi-component agents to modulate the complex immune system in the prevention of infections rather than treating the immune-related diseases. Many therapeutic effects of plant extracts have been suggested to be due to their wide array of immunomodulatory effects and influence on the immune system of the human body. Phytochemicals such as flavonoids, polysaccharides, lactones, alkaloids, diterpenoids and glycosides, present in several plants, have been reported to be responsible for the plants immunomodulating properties. Thus the search for natural products of plant origin as new leads for development of potent and safe immunosuppressant and immunostimulant agents is gaining much major research

  5. Formulating blackberry leaf mixtures for preparation of infusions with plant derived sources of sweeteners.

    Science.gov (United States)

    Komes, Draženka; Belščak-Cvitanović, Ana; Ljubičić, Ivan; Durgo, Ksenija; Cindrić, Iva Juranović; Bušić, Arijana; Vojvodić, Aleksandra

    2014-05-15

    Herbal mixtures composed of blackberry leaf and natural sweeteners (dried apples, prunes, figs, raisins, apricots, carrot and sweet potato, stevia leaves and liquorice root) were developed. Their nutritive and bioactive profile, biological activity and sensory properties were determined. Formulated mixtures exhibited lower total polyphenol content (259.09-350.00 mg GAE/L) when compared to plain blackberry leaf, but contained higher content of chlorogenic, ferulic, p-coumaric, rosmarinic acids and quercetin, as well as some macroelements (Ca, K, Mg) and microelements (Ba, Na). Stevia addition to formulated mixtures ensured higher polyphenolic content. Dried carrot exhibited the highest (0.988 g/g) and liquorice the lowest (0.087 g/g) content of total sugars but it contributed to the sweetness with 574.48 mg/L of glycyrrhizic acid derivatives. Plain blackberry leaf extract exhibited cytotoxic and antioxidative activity on human colon cancer cells. Formulated mixtures exhibited improved flavour profile and balanced sweetness in relation to plain blackberry leaf infusion.

  6. In vitro inhibitory effects of plant-derived by-products against Cryptosporidium parvum

    Directory of Open Access Journals (Sweden)

    Teichmann Klaus

    2016-01-01

    Full Text Available Disposal of organic plant wastes and by-products from the food or pharmaceutical industries usually involves high costs. In the present study, 42 samples derived from such by-products were screened in vitro against Cryptosporidium parvum, a protozoan parasite that may contaminate drinking water and cause diarrhoea. The novel bioassay was previously established in the microtitre plate format. Human ileocaecal adenocarcinoma (HCT-8 cell cultures were seeded with C. parvum oocysts and parasite development was monitored by an indirect fluorescent antibody technique (IFAT and microscopic assessment for clusters of secondary infection (CSI. Minimum inhibitory concentrations (MICs and potential detrimental effects on the host cells were determined. An ethanolic extract from olive (Olea europaea pomace, after oil pressing and phenol recovery, reproducibly inhibited C. parvum development (MIC = 250–500 μg mL−1, IC50 = 361 (279–438 μg mL−1, IC90 = 467 (398–615 μg mL−1. Accordingly, tyrosol, hydroxytyrosol, trans-coniferyl alcohol and oleuropein were selected as reference test compounds, but their contributions to the observed activity of the olive pomace extract were insignificant. The established test system proved to be a fast and efficient assay for identifying anti-cryptosporidial activities in biological waste material and comparison with selected reference compounds.

  7. In vitro inhibitory effects of plant-derived by-products against Cryptosporidium parvum

    Science.gov (United States)

    Teichmann, Klaus; Kuliberda, Maxime; Schatzmayr, Gerd; Pacher, Thomas; Zitterl-Eglseer, Karin; Joachim, Anja; Hadacek, Franz

    2016-01-01

    Disposal of organic plant wastes and by-products from the food or pharmaceutical industries usually involves high costs. In the present study, 42 samples derived from such by-products were screened in vitro against Cryptosporidium parvum, a protozoan parasite that may contaminate drinking water and cause diarrhoea. The novel bioassay was previously established in the microtitre plate format. Human ileocaecal adenocarcinoma (HCT-8) cell cultures were seeded with C. parvum oocysts and parasite development was monitored by an indirect fluorescent antibody technique (IFAT) and microscopic assessment for clusters of secondary infection (CSI). Minimum inhibitory concentrations (MICs) and potential detrimental effects on the host cells were determined. An ethanolic extract from olive (Olea europaea) pomace, after oil pressing and phenol recovery, reproducibly inhibited C. parvum development (MIC = 250–500 μg mL−1, IC50 = 361 (279–438) μg mL−1, IC90 = 467 (398–615) μg mL−1). Accordingly, tyrosol, hydroxytyrosol, trans-coniferyl alcohol and oleuropein were selected as reference test compounds, but their contributions to the observed activity of the olive pomace extract were insignificant. The established test system proved to be a fast and efficient assay for identifying anti-cryptosporidial activities in biological waste material and comparison with selected reference compounds. PMID:27627637

  8. Advanced analytical techniques for the extraction and characterization of plant-derived essential oils by gas chromatography with mass spectrometry.

    Science.gov (United States)

    Waseem, Rabia; Low, Kah Hin

    2015-02-01

    In recent years, essential oils have received a growing interest because of the positive health effects of their novel characteristics such as antibacterial, antifungal, and antioxidant activities. For the extraction of plant-derived essential oils, there is the need of advanced analytical techniques and innovative methodologies. An exhaustive study of hydrodistillation, supercritical fluid extraction, ultrasound- and microwave-assisted extraction, solid-phase microextraction, pressurized liquid extraction, pressurized hot water extraction, liquid-liquid extraction, liquid-phase microextraction, matrix solid-phase dispersion, and gas chromatography (one- and two-dimensional) hyphenated with mass spectrometry for the extraction through various plant species and analysis of essential oils has been provided in this review. Essential oils are composed of mainly terpenes and terpenoids with low-molecular-weight aromatic and aliphatic constituents that are particularly important for public health.

  9. Rapid analytical method for the determination of aflatoxins in plant-derived dietary supplement and cosmetic oils.

    Science.gov (United States)

    Mahoney, Noreen; Molyneux, Russell J

    2010-04-14

    Consumption of edible oils derived from conventional crop plants is increasing because they are generally regarded as healthier alternatives to animal-based fats and oils. More recently, there has been increased interest in the use of alternative specialty plant-derived oils, including those from tree nuts (almonds, pistachios, and walnuts) and botanicals (borage, evening primrose, and perilla) both for direct human consumption (e.g., as salad dressings) and for the preparation of cosmetics, soaps, and fragrance oils. This has raised the issue as to whether or not exposure to aflatoxins can result from such oils. Although most crops are subject to analysis and control, it has generally been assumed that plant oils do not retain aflatoxins due to the high polarity and lipophobicity of these compounds. There is virtually no scientific evidence to support this supposition, and available information is conflicting. To improve the safety and consistency of botanicals and dietary supplements, research is needed to establish whether or not oils used directly, or in the formulation of products, contain aflatoxins. A validated analytical method for the analysis of aflatoxins in plant-derived oils is essential to establish the safety of dietary supplements for consumption or cosmetic use that contain such oils. The aim of this research was therefore to develop an HPLC method applicable to a wide variety of oils from different plant sources spiked with aflatoxins, thereby providing a basis for a comprehensive project to establish an intra- and interlaboratory validated analytical method for the analysis of aflatoxins in dietary supplements and cosmetics formulated with plant oils.

  10. Design and Analysis of Randomized and Approximation Algorithms (Dagstuhl Seminar 11241)

    OpenAIRE

    Dyer, Martin; Feige, Uriel; Frieze, Alan M.; Karpinski, Marek

    2011-01-01

    The Dagstuhl Seminar on ``Design and Analysis of Randomized and Approximation Algorithms'' (Seminar 11241) was held at Schloss Dagstuhl between June 13--17, 2011. There were 26 regular talks and several informal and open problem session contributions presented during this seminar. Abstracts of the presentations have been put together in this seminar proceedings document together with some links to extended abstracts and full papers.

  11. Black Nitrogen or Plant-Derived Organic Nitrogen - which Form is More Efficiently Sequestered in Soils?

    Science.gov (United States)

    López-Martín, María; Velasco-Molina, Marta; Knicker, Heike

    2014-05-01

    and approached those of the pots with fresh grass litter supporting the mobilization of black nitrogen and its uptake by plants. Our results point to the suggestion that N in PyOM and humified SOM have comparable biochemical stability. In order to test this hypothesis, a further experiment was set up mixtures of soil and humified 15N grass residues or aged 15N grass char to which fresh PyOM or fresh grass residues, respectively, were added. In addition solid-state 15N NMR spectroscopy was applied to disclose the nature of the sequestered N. REFERENCES Knicker, H., Almendros, G., González-Vila, F.J., Martín, F., Lüdemann, H.-D., 1996. 13C- and 15N-NMR spectroscopic examination of the transformation of organic nitrogen in plant biomass during thermal treatment. Soil Biology and Biochemistry, 28, 1053-1060.

  12. NKS/SOS-1 seminar on safety analysis

    Energy Technology Data Exchange (ETDEWEB)

    Lauridsen, K. [Risoe National Lab., Roskilde (Denmark); Anderson, K. [Karinta-Konsult (Sweden); Pulkkinen, U. [VTT Automation (Finland)

    2001-05-01

    The report describes presentations and discussions at a seminar held at Risoe on March 22-23, 2000. The title of the seminar was NKS/SOS-1 - Safety Analysis. It dealt with issues of relevance for the safety analysis for the entire nuclear safety field (notably reactors and nuclear waste repositories). Such issues were: objectives of safety analysis, risk criteria, decision analysis, expert judgement and risk communication. In addition, one talk dealt with criteria for chemical industries in Europe. The seminar clearly showed that the concept of risk is multidimensional, which makes clarity and transparency essential elements in risk communication, and that there are issues of common concern between different applications, such as how to deal with different kinds of uncertainty and expert judgement. (au)

  13. The effects of participating in the 3rd Nordcode seminar

    DEFF Research Database (Denmark)

    Hansen, Claus Thorp

    My motivation for co-organise and participate in the 3’rd Nordcode seminar was threefold. Firstly, it gave me an opportunity to get insight into the Nordcode research area, which is defined as communicative product design seen from a Nordic perspective. Secondly, I would learn about state......-of-the-art, current research questions and research methods within this research area. Thirdly, I had a change to meet and discuss with Nordic colleagues. In the invitation to the 3’rd Nordcode seminar “Design communication” the organisers outlined the seminar theme as follows: “Design is about communication in many...... to ensure good design. Topics include: · Semantic and aesthetic functions – How do products communicate? And how do designers communicate their thoughts about design intensions? · User involvement - How can users be involved in the design process? · User centred design - How can user requirements be handled...

  14. Texas Instruments Technical Seminar: Power Management and Wireless

    CERN Multimedia

    2006-01-01

    Monday 6 November TECHNICAL TRAINING SEMINAR 14:00 to 17:30 - Training Centre Auditorium (bldg. 593) Texas Instruments Technical Seminar: Power Management and Wireless Michael Scholtholt, Field Application Engineer / TEXAS INSTRUMENTS (US, D, CH) The range of power management products available today offers the possibility to find the best solution for each application. To select the right product it is therefore necessary to understand system requirements, how power supply products work, and where they differentiate. This Technical Training Seminar will also present an overview of how to choose the right RF platform based on markets and applications: nowadays almost everbody has at least one wireless product in use, and this tendency seems to increase significantly. Power Management Voltage mode vs. current mode control Differentiating DC/DC converters by analyzing control and compensation schemes: line / load regulation, transient response, BOM, board space, ease-of-use Introduction to evaluati...

  15. Texas Instruments Technical Seminar: Power Management and Wireless

    CERN Multimedia

    2006-01-01

    Monday 6 November TECHNICAL TRAINING SEMINAR 14:00 to 17:30 - Training Centre Auditorium (bldg. 593) Texas Instruments Technical Seminar: Power Management and Wireless Michael Scholtholt, Field Application Engineer / TEXAS INSTRUMENTS (US, D, CH) The range of power management products available today offers the possibility to find the best solution for each application. To select the right product it is therefore necessary to understand system requirements, how power supply products work, and where they differentiate. This Technical Training Seminar will also present an overview of how to choose the right RF platform based on markets and applications: nowadays almost everbody has at least one wireless product in use, and this tendency seems to increase significantly. Power Management Voltage mode vs. current mode control Differentiating DC/DC converters by analyzing control and compensation schemes: line / load regulation, transient response, BOM, board space, ease-of-use Introduction to evalu...

  16. Using the Nominal Group Technique to Select the Most Appropriate Topics for Postgraduate Research Students' Seminars

    Science.gov (United States)

    Jones, Sandra C.

    2004-01-01

    In 2003, the Faculty of Health & Behavioural Sciences at our university offered a series of postgraduate research seminars. The series of seminars, selected by a three-person faculty team, received a mixed reaction--some seminars attracted a large proportion of the students whereas others were poorly attended. Thus, it was decided to continue…

  17. IACTalks: an on-line archive of astronomy-related seminars

    DEFF Research Database (Denmark)

    Knapen, Johan H.; Pérez Prieto, Jorge A.; Shahbaz, Tariq

    2012-01-01

    We present IACTalks, a free and open access seminars archive (http://iactalks.iac.es) aimed at promoting astronomy and the exchange of ideas by providing high-quality scientific seminars to the astronomical community. The archive of seminars and talks given at the Instituto de Astrofi\\'isica de...

  18. An Evaluation of a Career Development Seminar Using Crites' Career Maturity Inventory.

    Science.gov (United States)

    Ganster, Daniel C.; Lovell, John E.

    Holland's (1973) theory served as a basis for designing a 15-hour career development seminar for 24 undergraduate students. A Solomon four-group design (Campbell and Stanley, 1963) was employed to evaluate the effectiveness of the seminar, with the Career Maturity Inventory (Crites, 1973) serving as the dependent measure. Seminar participants…

  19. Why Manufacturers Do--and Do Not--Attend Educational Seminars. SBDC Professional Enrichment.

    Science.gov (United States)

    Swanson, David

    Examination of numerous studies of executives of small manufacturing firms in Iowa offered insights on their attitudes and actions regarding educational seminars. Findings showed that 62.7 percent of manufacturers attended at least one seminar in the last year. The term "seminar" had a better customer satisfaction rating than…

  20. Manual for participants in the solar heating/cooling seminars

    Energy Technology Data Exchange (ETDEWEB)

    1976-01-01

    This manual was intended as a text for participants in the Solar Heating/Cooling seminars presented in conjunction with the ERDA Transportable Solar Laboratory in various regions of the US. The seminar was designed to introduce the practical aspects of solar heating/cooling systems to HVAC contractors, architects, engineers, and other interested individuals. The two-day course enabled the attendees to assess potential solar applications in their geographic area, including tools to do a preliminary design of the system and to analyze its economic benefits. (WDM)

  1. Guest speakers in a professional development seminar series.

    Science.gov (United States)

    Zorek, Joseph A; Katz, Norman L; Popovich, Nicholas G

    2011-03-10

    To evaluate the impact guest speakers have on student development in a professional development seminar series. Over a 5-semester period, presentations were given by 18 guest speakers as part of a professional development seminar series. A 28-item survey instrument was constructed and administered to 68 students to assess the impact of the guest speakers on the students' professional development. Forty-six (68%) students completed the survey instrument, and the results demonstrated the value of the guest speakers, most notably in the areas of career development and professional responsibility. Exposing pharmacy students to guest speakers from varied pharmacy career paths positively impacted students' knowledge of career options and professional development.

  2. Rondeau Seminars amalgamated mid-sagittal (lateral) cephalometric analysis.

    Science.gov (United States)

    Palencar, Adrian J

    2014-01-01

    The author presents a comprehensive International Association for Orthodontics--Rondeau Seminars Amalgamated Mid-sagittal (Lateral) Cephalometric Analysis. Norms on the Cephalometric Data Sheet are age and gender specific for the Caucasian population and the postings are color coded for visual attraction. If the patient is ofa different ethnic group, the Norms should be adjusted accordingly. This Cephalometric Analysis is comprised often Sections, in alphabetical order and twenty nine Factors. The author expanded Rondeau Seminars Cephalometric Analysis by only six Factors, thus fulfilling the requirement for the case presentation for the Fellow of the IAO and the Diplomate ofthe IBO.

  3. Seminar on Employment and Development of Town Women

    Institute of Scientific and Technical Information of China (English)

    1995-01-01

    IN October 1994, the All-China Women’s Federation held a seminar on the employment and development of town women in Shanghai, China’s largest city. The seminar was also a preparatory meeting for the ’95 NGO Forum on women’s employment. More than 70 people, including the presidents of the provincial women’s federations, the municipal women’s federations and some leaders of the state departments concerned attended this meeting. Chen Muhua, Vice-Chairwoman of the Standing Committee of the NPC, the

  4. Preclinical and first-in-human evaluation of PRX-105, a PEGylated, plant-derived, recombinant human acetylcholinesterase-R

    Energy Technology Data Exchange (ETDEWEB)

    Atsmon, Jacob [Clinical Research Center, Tel Aviv Sourasky Medical Center, Tel Aviv (Israel); Sackler Faculty of Medicine, Tel Aviv University (Israel); Brill-Almon, Einat; Nadri-Shay, Carmit; Chertkoff, Raul; Alon, Sari [Protalix Biotherapeutics, Science Park, Carmiel (Israel); Shaikevich, Dimitri; Volokhov, Inna; Haim, Kirsten Y. [Clinical Research Center, Tel Aviv Sourasky Medical Center, Tel Aviv (Israel); Sackler Faculty of Medicine, Tel Aviv University (Israel); Bartfeld, Daniel [Protalix Biotherapeutics, Science Park, Carmiel (Israel); Shulman, Avidor, E-mail: avidors@protalix.com [Protalix Biotherapeutics, Science Park, Carmiel (Israel); Ruderfer, Ilya; Ben-Moshe, Tehila; Shilovitzky, Orit [Protalix Biotherapeutics, Science Park, Carmiel (Israel); Soreq, Hermona [Department of Biological Chemistry, Institute of Life Sciences, The Hebrew University of Jerusalem (Israel); Shaaltiel, Yoseph [Protalix Biotherapeutics, Science Park, Carmiel (Israel)

    2015-09-15

    PRX-105 is a plant-derived recombinant version of the human ‘read-through’ acetylcholinesterase splice variant (AChE-R). Its active site structure is similar to that of the synaptic variant, and it displays the same affinity towards organophosphorus (OP) compounds. As such, PRX-105 may serve as a bio-scavenger for OP pesticides and chemical warfare agents. To assess its potential use in prophylaxis and treatment of OP poisoning we conducted several preliminary tests, reported in this paper. Intravenous (IV) PRX-105 was administered to mice either before or after exposure to an OP toxin. All mice who received an IV dose of 50 nmol/kg PRX-105, 2 min before being exposed to 1.33 × LD{sub 50} and 1.5 × LD{sub 50} of toxin and 10 min after exposure to 1.5 × LD{sub 50} survived. The pharmacokinetic and toxicity profiles of PRX-105 were evaluated in mice and mini-pigs. Following single and multiple IV doses (50 to 200 mg/kg) no deaths occurred and no significant laboratory and histopathological changes were observed. The overall elimination half-life (t{sub ½}) in mice was 994 (± 173) min. Additionally, a first-in-human study, to assess the safety, tolerability and pharmacokinetics of the compound, was conducted in healthy volunteers. The t{sub ½} in humans was substantially longer than in mice (average 26.7 h). Despite the small number of animals and human subjects who were assessed, the fact that PRX-105 exerts a protective and therapeutic effect following exposure to lethal doses of OP, its favorable safety profile and its relatively long half-life, renders it a promising candidate for treatment and prophylaxis against OP poisoning and warrants further investigation. - Highlights: • PRX-105 is a PEGylated plant-derived recombinant human acetylcholinesterase-R. • PRX-105 is a promising bio-scavenger for organophosphorous toxins at lethal doses. • PRX-105 was shown to protect animals both prophylactically and post-poisoning. • First-in-human study

  5. A Seminar in Mathematical Model-Building.

    Science.gov (United States)

    Smith, David A.

    1979-01-01

    A course in mathematical model-building is described. Suggested modeling projects include: urban problems, biology and ecology, economics, psychology, games and gaming, cosmology, medicine, history, computer science, energy, and music. (MK)

  6. Sal k 4, a new allergen of Salsola kali, is profilin: a predictive value of conserved conformational regions in cross-reactivity with other plant-derived profilins.

    Science.gov (United States)

    Assarehzadegan, Mohammad Ali; Amini, Akram; Sankian, Mojtaba; Tehrani, Mohsen; Jabbari, Farahzad; Varasteh, Abdolreza

    2010-01-01

    The aim of this study was to investigate a new allergen of Salsola kali, Sal k 4, and to investigate the predictive value of the conserved conformational regions in cross-reactivity with other plant-derived profilins. The Sal k 4-coding sequence was cloned, expressed, and purified by one-step Ni2+ affinity chromatography to recover high-purity target protein. We assessed cross-reactivity and predicted conserved conformational regions among rSal k 4 and other plant-derived profilins. Immunodetection and inhibition assays using 30 individual sera from S. kali allergic patients indicated that purified rSal k 4 might be the same as that in the crude extract. The results of inhibition assays among rSal k 4 and other plant-derived profilins were in accordance with the homology of the predicted conserved conformational regions. Amino acid sequence homology analysis showed that a high degree of IgE cross-reactivity among plant-derived profilins might depend on the predicted conserved conformational regions.

  7. Seminar on K-Theory, Arithmetic and Geometry

    CERN Document Server

    1987-01-01

    This volume of research papers is an outgrowth of the Manin Seminar at Moscow University, devoted to K-theory, homological algebra and algebraic geometry. The main topics discussed include additive K-theory, cyclic cohomology, mixed Hodge structures, theory of Virasoro and Neveu-Schwarz algebras.

  8. Ice Cream Seminars for Graduate Students: Imparting Chemical Information Literacy

    Science.gov (United States)

    Garritano, Jeremy R.

    2007-01-01

    This article provides information on a chemical information literacy program designed primarily for new graduate students. The full implementation of this program is discussed, including defining its purpose, topics covered, content presented, methods of marketing, and evaluation. The result is a series of voluntary seminars given biweekly…

  9. Proceedings from the Nordcode Seminar. Participation and Dialogue

    Directory of Open Access Journals (Sweden)

    Liv Merete Nielsen

    2012-08-01

    Full Text Available This issue of FORMakademisk is the result of a cooperative effort involving the Nordcode research network, the Department of Product Design at Akershus University College and the FORMakademisk. It builds on the Participation and Dialogue seminar, held in May 2010, which was supported by Nordforsk, The Norwegian Research Council and Kjeller Science Park.

  10. Communicating about Sexuality: An Interdisciplinary Undergraduate Honors Seminar.

    Science.gov (United States)

    Rozema, Hazel J.

    A course in the honors program (a sophomore level social science seminar) at Millikin University offers an interdisciplinary approach to communication and sexuality, functions as a course in the Gender Studies Minor curriculum, and provides a needed source of sex education for the campus. The purpose of the course is to facilitate communication…

  11. 1982 UCC-ND/GAT environmental protection seminar: proceedings

    Energy Technology Data Exchange (ETDEWEB)

    1983-04-01

    This environmental protection seminar was divided into seven sessions: (1) general environmental protection, (2) air and water pollution control, (3) spill control and countermeasures, (4) toxic materials control, (5) hazardous materials control, (6) environmental protection projects, and (7) cost benefit analysis. Separate abstracts have been prepared for the 41 papers presented therein. (ACR)

  12. A SEMINAR-DISCUSSION-BASED APPROACH TOWARD LINGUISTICS

    Institute of Scientific and Technical Information of China (English)

    郎勇

    2002-01-01

    In this article, based on the experience of many years of teaching Linguistics courses to undergraduates, postgraduates and in-service teacher trainees, we argue that taking a seminar-discussion-based approach is a better way to achieve students' full involvement and understanding.

  13. Seminar in Language and Language Learning. Final Report.

    Science.gov (United States)

    Washington Univ., Seattle.

    Collected here are ten unpublished work papers from a 1962 Seminar in Seattle, held for the purpose of evaluating the interdisciplinary needs of the doctoral candidate who is receiving special training to organize the teaching of foreign languages in schools and universities. Authors are Dwight L. Bolinger (linguistics), John B. Carroll (programed…

  14. Fulbright-Hays Seminars Abroad Program: Malaysia 1995. Participants' Reports.

    Science.gov (United States)

    Malaysian-American Commission on Educational Exchange, Kuala Lumpur.

    These reports and lesson plans were developed by teachers and coordinators who traveled to Malaysia during the summer of 1995 as part of the U.S. Department of Education's Fulbright-Hays Seminars Abroad Program. Sections of the report include: (1) "Gender and Economics: Malaysia" (Mary C. Furlong); (2) "Malaysia: An Integrated,…

  15. Mexico 1996. Fulbright-Hays Summer Seminar Abroad 1996 (Mexico).

    Science.gov (United States)

    Lopez, Salvador

    This paper shares the impressions of a participant from the 1996 Fulbright-Hays Summer Seminars Abroad Program in Mexico. These impressions address several current interest topics about international relations with Mexico including: (1) immigration; (2) politics; (3) education; (4) the economy; (5) the environment; (6) the media; (7) religion; and…

  16. Teaching Critical Thinking: Using Seminars for 21st Century Literacy

    Science.gov (United States)

    Roberts, Terry; Billings, Laura

    2012-01-01

    Help students meet today's literacy demands with this new book from Terry Roberts and Laura Billings. The authors show how a seminar approach can lead students deeper into a text and improve their speaking, listening, and writing skills, as recommended by the Common Core State Standards. Roberts and Billings provide easy-to-follow information on…

  17. Seminar of contemporary Estonian literature and translation in Hungary

    Index Scriptorium Estoniae

    2002-01-01

    Sept-st 2002 töötab Budapesti ülikoolis soome-ugri kateedri juures tänapäeva eesti kirjanduse ja tõlkimise seminar, asutatud ülikooli ja Eesti Instituudi koostöö tulemusena. Põhiorganisaatoriks oli Eesti Instituut Ungaris

  18. National seminar on tree improvement, January 8, 1981

    Energy Technology Data Exchange (ETDEWEB)

    1981-01-01

    Twenty one papers are presented from this seminar held at Kumarapumal Farm Science Centre, Tiruchira. An introductory paper gives a resume of tree improvement work in Tamil Nadu University and this is followed by papers on improvement of eucalypts (11), Casuarina, teak (3) and other species (3 papers on sandal, cashew and gamma irradiation of amla (Emblica officinalis seeds)).

  19. Socio-Technical Security Metrics (Dagstuhl Seminar 14491)

    NARCIS (Netherlands)

    Gollmann, Dieter; Herley, Cormac; Koenig, Vincent; Pieters, Wolter; Sasse, Martina Angela

    2015-01-01

    This report documents the program and the outcomes of Dagstuhl Seminar 14491 "Socio-Technical Security Metrics". In the domain of safety, metrics inform many decisions, from the height of new dikes to the design of nuclear plants. We can state, for example, that the dikes should be high enough to gu

  20. Seminar on Sanitation for Restaurant Owners and Managers. Unit II.

    Science.gov (United States)

    Threlkeld, Joyce C.

    Intended for use in conducting short seminars on sanitation for restaurant owners and managers, unit two of the curriculum guide is organized to provide four hours of classroom instruction. Four major concepts are emphasized. The first concept, providing sanitary conditions in food service establishments, discusses safe use and storage of cleaning…

  1. Seminar On Sanitation for Restaurant Owners and Managers. Unit I.

    Science.gov (United States)

    Threlkeld, Joyce C.

    Intended for use in conducting short seminars on sanitation for restaurant owners and managers, the conceptual outline is organized to provide four hours of classroom instruction. Two major concepts are emphasized. The first concept, the effect of sanitary practices on the financial profits of food service, focuses on: (1) service and quality to…

  2. A Successful Senior Seminar: Unsolved Problems in Number Theory

    Science.gov (United States)

    Styer, Robert

    2014-01-01

    The "Unsolved Problems in Number Theory" book by Richard Guy provides nice problems suitable for a typical math major. We give examples of problems that have worked well in our senior seminar course and some nice results that senior math majors can obtain.

  3. Best-effort Support for a Virtual Seminar Room

    DEFF Research Database (Denmark)

    Sharp, Robin; Todirica, Edward Alexandru

    2002-01-01

    This paper describes the RTMM Virtual Seminar Room, an interactive distributed multimedia application based on a platform with a simple middleware architecture, using best effort scheduling and a best effort network service. Emphasis has been placed on achieving low latency in all parts...

  4. Hamlet on the Macintosh: An Experimental Seminar That Worked.

    Science.gov (United States)

    Strange, William C.

    1987-01-01

    Describes experimental college Shakespeare seminar that used Macintosh computers and software called ELIZA and ADVENTURE to develop character dialogs and adventure games based on Hamlet's characters and plots. Programming languages are examined, particularly their relationship to metaphor, and the use of computers in humanities is discussed. (LRW)

  5. 11th International Seminar on Stability Problems for Stochastic Models

    CERN Document Server

    Zolotarev, Vladimir

    1989-01-01

    Traditionally the Stability seminar, organized in Moscow but held in different locations, has dealt with a spectrum of topics centering around characterization problems and their stability, limit theorems, probabil- ity metrics and theoretical robustness. This volume likewise focusses on these main topics in a series of original and recent research articles.

  6. Proceedings of the 1986 seminar on nuclear data

    Energy Technology Data Exchange (ETDEWEB)

    Nakagawa, Tsuneo; Asami, Tetsuo (eds.)

    1987-02-15

    The seminar focused on problems with nuclear data and reactor constants and their sensitivity analyses. The poster session concerned recent measurements of neutron cross sections and computer codes for theoretical calculations. Separate abstracts were prepared for 34 papers in these proceedings. (DWL)

  7. Exploring seminar learning in relation to students, teachers and context

    NARCIS (Netherlands)

    Spruijt, A.

    2014-01-01

    Seminar learning Veterinarians nowadays need to be equipped with knowledge and skills such as critical scientific thinking, analysing information, problem solving, and making decisions. Development of these skills demands other instructional methods than the traditional ‘transmission of knowledge’ t

  8. GCLR Web Seminars as a Venue for Transformative Educational Policy

    Science.gov (United States)

    Angay-Crowder, Tuba; Albers, Peggy; Pace, Christi L.; Jung, Jin Kyeong Frances; Hwang, Ju A.; Pang, Myoung Eun

    2014-01-01

    This article features a discussion about the significance of global perspectives in shaping critical literacy through a web seminar project, Global Conversations in Literacy Research (GCLR). Ubiquitous media and worldwide communication via Internet change the perceptions about literacy and language, urging critical discussions around literacy…

  9. Hamlet on the Macintosh: An Experimental Seminar That Worked.

    Science.gov (United States)

    Strange, William C.

    1987-01-01

    Describes experimental college Shakespeare seminar that used Macintosh computers and software called ELIZA and ADVENTURE to develop character dialogs and adventure games based on Hamlet's characters and plots. Programming languages are examined, particularly their relationship to metaphor, and the use of computers in humanities is discussed. (LRW)

  10. Seminar "Pargid ja aiad". Näitus "Kaotatud paradiis"

    Index Scriptorium Estoniae

    2006-01-01

    29. IX Euroopa muinsuskaitsepäevade raames toimus Toomemäe pargi 200. aastapäevale pühendatud seminar. Tartu Ülikooli Ajaloomuuseumis avati Tartumaa rüütlimõisate parke tutvustav näitus "Kaotatud paradiis", mis põhines maastikuarhitekt Nele Nuti magistritööks kogutud andmetel

  11. Seminar of contemporary Estonian literature and translation in Hungary

    Index Scriptorium Estoniae

    2002-01-01

    Sept-st 2002 töötab Budapesti ülikoolis soome-ugri kateedri juures tänapäeva eesti kirjanduse ja tõlkimise seminar, asutatud ülikooli ja Eesti Instituudi koostöö tulemusena. Põhiorganisaatoriks oli Eesti Instituut Ungaris

  12. Enhancing Leadership Education: Insights from a Seminar Evaluation

    Science.gov (United States)

    Lyman, Linda L.; Gardner, Dianne C.

    2008-01-01

    Definitions are central to both the practice and the power of leadership. This deceptively simple supposition was the basis for an elective doctoral leadership seminar at Illinois State University designed and taught by Lyman in Fall 2005, and replicated by Gardner in Spring 2007. The authors featured the same texts and stimulated students'…

  13. Serious Games: A Seminar Map for International Business Schools

    Science.gov (United States)

    Witte, Anne E.

    2014-01-01

    One business school addressed the "zeitgeist" of the financial crisis by introducing in its inaugural seminar the cultural and ethical values too often absent from the types of transactions students are trained to manage. Drawing from cross-cultural and communication studies, the author tested "serious games"--cultural…

  14. Seminar "Pargid ja aiad". Näitus "Kaotatud paradiis"

    Index Scriptorium Estoniae

    2006-01-01

    29. IX Euroopa muinsuskaitsepäevade raames toimus Toomemäe pargi 200. aastapäevale pühendatud seminar. Tartu Ülikooli Ajaloomuuseumis avati Tartumaa rüütlimõisate parke tutvustav näitus "Kaotatud paradiis", mis põhines maastikuarhitekt Nele Nuti magistritööks kogutud andmetel

  15. Ice Cream Seminars for Graduate Students: Imparting Chemical Information Literacy

    Science.gov (United States)

    Garritano, Jeremy R.

    2007-01-01

    This article provides information on a chemical information literacy program designed primarily for new graduate students. The full implementation of this program is discussed, including defining its purpose, topics covered, content presented, methods of marketing, and evaluation. The result is a series of voluntary seminars given biweekly…

  16. The 2nd Seminar on Standardization Cooperation in Northeast Asia

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    @@ The 2nd Seminar on Standardization Cooperation in Northeast Asia(2003) was held in Beijing from Oct 30th - Oct 31st, which was the succession of the first one in Korea, 2002, with the participants coming from the standardization circles in China, Japan and Korea.

  17. Structuring an Undergraduate Mathematics Seminar Dealing with Options and Hedging

    Science.gov (United States)

    Prevot, K. J.

    2006-01-01

    Offering mathematics majors the opportunity to engage in current, real-world applications can be an important enhancement to their undergraduate course curriculum. Instead of focusing on the traditional topic areas in pure and/or applied mathematics, one may structure a seminar course for senior mathematics majors by concentrating on a specific…

  18. Seminar `EurepGAP Certification & Smallholders' : Nairobi, 22 November, 2006

    NARCIS (Netherlands)

    Joosten, F.J.; Jansen, D.M.

    2006-01-01

    The main aim of the Seminar 'EurepGAP certification & smallholders' was to share experiences with the introduction and institutionalisation of quality systems such as EurepGAP between stakeholders in the export_oriented horticultural sectors of Kenya, Tanzania, Ethiopia, Zambia, and Uganda. By s

  19. Gender, land use and environmental management; introduction to a seminar

    NARCIS (Netherlands)

    Bruijn, de M.E.; Halsema, van I.; Hombergh, van den H.

    1997-01-01

    Gender, land use and environmental management in developing countries intersect in a complex setting in which culture, economics and politics interfere. This collective volume - the product of a seminar organized in Amsterdam in May 1995 - unravels these complexities. The introductory chapter (gende

  20. Material Feminist Practices in a Body Politics Seminar

    Science.gov (United States)

    Stein, Rachel

    2014-01-01

    In this article, Rachel Stein focuses on two course projects in which students apply materialist feminist practices within a capstone women's studies seminar entitled Body Politics. Undertaking these projects, students become more critically aware of gendered materialities that they had previously taken for granted as they deconstruct material…

  1. Effect of Silane Coupling Agent on Tribological Properties of Hemp Fiber-Reinforced Plant-Derived Polyamide 1010 Biomass Composites.

    Science.gov (United States)

    Nishitani, Yosuke; Kajiyama, Tetsuto; Yamanaka, Toshiyuki

    2017-09-05

    We have studied the effects of silane coupling agents used for the surface treatment of fiber on the tribological properties of hemp fiber (HF) reinforced plant-derived polyamide 1010 (PA1010) biomass composites. Hemp fibers were surface-treated by two surface treatment methods: (a) alkali treatment by sodium hydroxide solution and (b) surface treatment by silane coupling agents. Three types of silane coupling agents, namely aminosilane, epoxysilane and ureidosilane were used. These HF/PA1010 biomass composites were extruded using a twin extruder, and injection-molded. The mechanical and tribological properties were evaluated by the ring-on-plate type sliding wear test. It was found that tribological properties of HF/PA1010 biomass composites improved with the surface treatment by the silane coupling agent. This may be attributed to the change in the mode of friction and wear mechanism by the interfacial adhesion between fiber and matrix polymer according to the type of silane coupling agent used. In particular, the ureidosilane coupling agent showed the best improvement effect for the tribological properties of these biomass composites in this study.

  2. The Plant-Derived Bauhinia bauhinioides Kallikrein Proteinase Inhibitor (rBbKI) Attenuates Elastase-Induced Emphysema in Mice.

    Science.gov (United States)

    Martins-Olivera, Bruno Tadeu; Almeida-Reis, Rafael; Theodoro-Júnior, Osmar Aparecido; Oliva, Leandro Vilela; Neto Dos Santos Nunes, Natalia; Olivo, Clarice Rosa; Vilela de Brito, Marlon; Prado, Carla Máximo; Leick, Edna Aparecida; Martins, Mílton de Arruda; Oliva, Maria Luiza Vilela; Righetti, Renato Fraga; Tibério, Iolanda de Fátima Lopes Calvo

    2016-01-01

    Background. Elastase mediates important oxidative actions during the development of chronic obstructive pulmonary disease (COPD). However, few resources for the inhibition of elastase have been investigated. Our study evaluated the ability of the recombinant plant derived Bauhinia bauhinioides Kallikrein proteinase Inhibitor (rBbKI) to modulate elastase-induced pulmonary inflammation. Methods. C57Bl/6 mice were given intratracheal elastase (ELA group) or saline (SAL group) and were treated intraperitoneally with rBbKI (ELA-rBbKI and SAL-rBbKI groups). At day 28, the following analyses were performed: (I) lung mechanics, (II) exhaled nitric oxide (ENO), (III) bronchoalveolar lavage fluid (BALF), and (IV) lung immunohistochemical staining. Results. In addition to decreasing mechanical alterations and alveolar septum disruption, rBbKI reduced the number of cells in the BALF and decreased the cellular expression of TNF-α, MMP-9, MMP-12, TIMP-1, eNOS, and iNOS in airways and alveolar walls compared with the ELA group. rBbKI decreased the volume proportion of 8-iso-PGF2α, collagen, and elastic fibers in the airways and alveolar walls compared with the ELA group. A reduction in the number of MUC-5-positive cells in the airway walls was also observed. Conclusion. rBbKI reduced elastase-induced pulmonary inflammation and extracellular matrix remodeling. rBbKI may be a potential pharmacological tool for COPD treatment.

  3. Plant-derived flavone Apigenin: The small-molecule with promising activity against therapeutically resistant prostate cancer.

    Science.gov (United States)

    Ganai, Shabir Ahmad

    2017-01-01

    Prostate cancer is the second leading cause of cancer related deaths in men in the United States. Mounting evidences suggest that in the pathophysiology of prostate cancer epigenetic modifications play a considerable role. Histone deacetylases (HDACs) have strong crosstalk with prostate cancer progression as they regulate various genes meant for tumour suppression. HDACs are emerging as striking molecular targets for anticancer drugs and therapy as their aberrant expression has been implicated in several cancers. Histone deacetylase inhibitors (HDACi), the small molecules interfering HDACs are the propitious chemotherapeutic agents as they tune the altered acetylation homeostasis for attenuating disease signalling. More than 20 HDACi have entered into the clinical trials and 4 have crossed the journey by gaining FDA approval for treating distinct haematological malignancies including multiple myeloma. Despite the therapeutic benefits, the synthetic HDACi cause detrimental side effects like atrial fibrillation, raising concerns regarding their applicability. Taking these facts into consideration the current article focused on plant-derived HDAC inhibitor Apigenin and its marvelous role in prostate cancer therapy. Moreover, the article sheds light on Apigenin induced apoptosis in various prostate cancer models. The defined inhibitor provokes apoptotic signaling in these models by multiple mechanisms like restraining HDACs, declining the levels of antiapoptotic proteins. Importantly, Apigenin hampers NF-κB signalling and down-modulates its regulated gene products for bringing therapeutic effect. Furthermore, Apigenin shows synergistic effect in combinatorial therapy and induces apoptosis even in prostate cancer models resistant to conventional therapeutic regimens. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  4. The Plant-Derived Bauhinia bauhinioides Kallikrein Proteinase Inhibitor (rBbKI Attenuates Elastase-Induced Emphysema in Mice

    Directory of Open Access Journals (Sweden)

    Bruno Tadeu Martins-Olivera

    2016-01-01

    Full Text Available Background. Elastase mediates important oxidative actions during the development of chronic obstructive pulmonary disease (COPD. However, few resources for the inhibition of elastase have been investigated. Our study evaluated the ability of the recombinant plant derived Bauhinia bauhinioides Kallikrein proteinase Inhibitor (rBbKI to modulate elastase-induced pulmonary inflammation. Methods. C57Bl/6 mice were given intratracheal elastase (ELA group or saline (SAL group and were treated intraperitoneally with rBbKI (ELA-rBbKI and SAL-rBbKI groups. At day 28, the following analyses were performed: (I lung mechanics, (II exhaled nitric oxide (ENO, (III bronchoalveolar lavage fluid (BALF, and (IV lung immunohistochemical staining. Results. In addition to decreasing mechanical alterations and alveolar septum disruption, rBbKI reduced the number of cells in the BALF and decreased the cellular expression of TNF-α, MMP-9, MMP-12, TIMP-1, eNOS, and iNOS in airways and alveolar walls compared with the ELA group. rBbKI decreased the volume proportion of 8-iso-PGF2α, collagen, and elastic fibers in the airways and alveolar walls compared with the ELA group. A reduction in the number of MUC-5-positive cells in the airway walls was also observed. Conclusion. rBbKI reduced elastase-induced pulmonary inflammation and extracellular matrix remodeling. rBbKI may be a potential pharmacological tool for COPD treatment.

  5. In Vitro Evaluation of Sub-Lethal Concentrations of Plant-Derived Antifungal Compounds on FUSARIA Growth and Mycotoxin Production

    Directory of Open Access Journals (Sweden)

    Caterina Morcia

    2017-07-01

    Full Text Available Phytopathogenic fungi can lead to significant cereal yield losses, also producing mycotoxins dangerous for human and animal health. The fungal control based on the use of synthetic fungicides can be complemented by "green" methods for crop protection, based on the use of natural products. In this frame, the antifungal activities of bergamot and lemon essential oils and of five natural compounds recurrent in essential oils (citronellal, citral, cinnamaldehyde, cuminaldehyde and limonene have been evaluated against three species of mycotoxigenic fungi (Fusarium sporotrichioides, F. graminearum and F. langsethiae responsible for Fusarium Head Blight in small-grain cereals. The natural products concentrations effective for reducing or inhibiting the in vitro fungal growth were determined for each fungal species and the following scale of potency was found: cinnamaldehyde > cuminaldehyde > citral > citronellal > bergamot oil > limonene > lemon oil. Moreover, the in vitro mycotoxin productions of the three Fusaria strains exposed to sub-lethal concentrations of the seven products was evaluated. The three fungal species showed variability in response to the treatments, both in terms of inhibition of mycelial growth and in terms of modulation of mycotoxin production that can be enhanced by sub-lethal concentrations of some natural products. This last finding must be taken into account in the frame of an open field application of some plant-derived fungicides.

  6. Treponema pallidum putative novel drug target identification and validation: rethinking syphilis therapeutics with plant-derived terpenoids.

    Science.gov (United States)

    Dwivedi, Upendra N; Tiwari, Sameeksha; Singh, Priyanka; Singh, Swati; Awasthi, Manika; Pandey, Veda P

    2015-02-01

    Syphilis, a slow progressive and the third most common sexually transmitted disease found worldwide, is caused by a spirochete gram negative bacteria Treponema pallidum. Emergence of antibiotic resistant T. pallidum has led to a search for novel drugs and their targets. Subtractive genomics analyses of pathogen T. pallidum and host Homo sapiens resulted in identification of 126 proteins essential for survival and viability of the pathogen. Metabolic pathway analyses of these essential proteins led to discovery of nineteen proteins distributed among six metabolic pathways unique to T. pallidum. One hundred plant-derived terpenoids, as potential therapeutic molecules against T. pallidum, were screened for their drug likeness and ADMET (absorption, distribution, metabolism, and toxicity) properties. Subsequently the resulting nine terpenoids were docked with five unique T. pallidum targets through molecular modeling approaches. Out of five targets analyzed, D-alanine:D-alanine ligase was found to be the most promising target, while terpenoid salvicine was the most potent inhibitor. A comparison of the inhibitory potential of the best docked readily available natural compound, namely pomiferin (flavonoid) with that of the best docked terpenoid salvicine, revealed that salvicine was a more potent inhibitor than that of pomiferin. To the best of our knowledge, this is the first report of a terpenoid as a potential therapeutic molecule against T. pallidum with D-alanine:D-alanine ligase as a novel target. Further studies are warranted to evaluate and explore the potential clinical ramifications of these findings in relation to syphilis that has public health importance worldwide.

  7. Creating Online Lessons: A Faculty Development Seminar Series

    Directory of Open Access Journals (Sweden)

    Deborah Sleight, PhD

    2003-02-01

    Full Text Available The World Wide Web is being used increasingly to deliver instruction in medical education. Consequently, there is a need to train faculty in developing and implementing online instruction. We developed and implemented a seminar series to teach faculty to create educationally sound, well designed online instruction. Instruction was delivered to 15 participants via a six session seminar on developing web based lessons, supplemented with web-based instruction. First, the participants learned the basics of instructional design via a web based module. They then completed content outlines for their online lessons prior to the first seminar. Lesson development, web site development and the use of a web based instructional shell to implement the online lessons were each taught in two two hour sessions. Eight participants developed online lessons and four actually implemented them. Feedback was mostly positive, with suggestions for improvement. All eight participants who completed the series said they would recommend it to their colleagues. Because a longitudinal workshop type of seminar series requires a large amount of participant time outside of class, a six month seminar series may be too long. It is important at the beginning of the series to help participants select topics suitable for online instruction and to help them narrow their topics. We may change the attendance guidelines so faculty would attend only the session on instructional design and have their staff attend the technical sessions on web site design, HTML editing and online course delivery systems. This would better match the actual practice of faculty designing the instruction and staff developing it. HTML (Browser version of the article

  8. Priming in permafrost soils: High vulnerability of arctic soil organic carbon to increased input of plant-derived compounds

    Science.gov (United States)

    Wild, Birgit; Gentsch, Norman; Capek, Petr; Diakova, Katerina; Alves, Ricardo; Barta, Jiri; Gittel, Antje; Guggenberger, Georg; Lashchinskiy, Nikolay; Knoltsch, Anna; Mikutta, Robert; Santruckova, Hana; Schnecker, Jörg; Shibistova, Olga; Takriti, Mounir; Urich, Tim; Watzka, Margarete; Richter, Andreas

    2015-04-01

    Arctic ecosystems are warming rapidly, resulting in a stimulation of both plant primary production and soil organic matter (SOM) decomposition. In addition to this direct stimulation, SOM decomposition might also be indirectly affected by rising temperatures mediated by the increase in plant productivity. Higher root litter production for instance might decrease SOM decomposition by providing soil microorganisms with alternative C and N sources ("negative priming"), or might increase SOM decomposition by facilitating microbial growth and enzyme production ("positive priming"). With about 1,700 Pg of organic C stored in arctic soils, and 88% of that in horizons deeper than 30 cm, it is crucial to understand the controls on SOM decomposition in different horizons of arctic permafrost soils, and thus the vulnerability of SOM to changes in C and N availability in a future climate. We here report on the vulnerability of SOM in arctic permafrost soils to an increased input of plant-derived organic compounds, and on its variability across soil horizons and sites. We simulated an increased input of plant-derived compounds by amending soil samples with 13C-labelled cellulose or protein, and compared the mineralization of native, unlabelled soil organic C (SOC) to unamended control samples. Our experiment included 119 individual samples of arctic permafrost soils, covering four sites across the Siberian Arctic, and five soil horizons, i.e., organic topsoil, mineral topsoil, mineral subsoil and cryoturbated material (topsoil material buried in the subsoil by freeze-thaw processes) from the active layer, as well as thawed material from the upper permafrost. Our findings suggest that changes in C and N availability in Arctic soils, such as mediated by plants, have a high potential to alter the decomposition of SOM, but also point at fundamental differences between soil horizons. In the organic topsoil, SOC mineralization increased by 51% after addition of protein, but was not

  9. How plants sense wounds: damaged-self recognition is based on plant-derived elicitors and induces octadecanoid signaling.

    Directory of Open Access Journals (Sweden)

    Martin Heil

    Full Text Available BACKGROUND: Animal-derived elicitors can be used by plants to detect herbivory but they function only in specific insect-plant interactions. How can plants generally perceive damage caused by herbivores? Damaged-self recognition occurs when plants perceive molecular signals of damage: degraded plant molecules or molecules localized outside their original compartment. METHODOLOGY/PRINCIPAL FINDINGS: Flame wounding or applying leaf extract or solutions of sucrose or ATP to slightly wounded lima bean (Phaseolus lunatus leaves induced the secretion of extrafloral nectar, an indirect defense mechanism. Chemically related molecules that would not be released in high concentrations from damaged plant cells (glucose, fructose, salt, and sorbitol did not elicit a detectable response, excluding osmotic shock as an alternative explanation. Treatments inducing extrafloral nectar secretion also enhanced endogenous concentrations of the defense hormone jasmonic acid (JA. Endogenous JA was also induced by mechanically damaging leaves of lima bean, Arabidopsis, maize, strawberry, sesame and tomato. In lima bean, tomato and sesame, the application of leaf extract further increased endogenous JA content, indicating that damaged-self recognition is taxonomically widely distributed. Transcriptomic patterns obtained with untargeted 454 pyrosequencing of lima bean in response to flame wounding or the application of leaf extract or JA were highly similar to each other, but differed from the response to mere mechanical damage. We conclude that the amount or concentration of damaged-self signals can quantitatively determine the intensity of the wound response and that the full damaged-self response requires the disruption of many cells. CONCLUSIONS/SIGNIFICANCE: Numerous compounds function as JA-inducing elicitors in different plant species. Most of them are, contain, or release, plant-derived molecular motifs. Damaged-self recognition represents a taxonomically

  10. Plant-Derived MINA-05 Inhibits Human Prostate Cancer Proliferation In Vitro and Lymph Node Spread In Vivo

    Directory of Open Access Journals (Sweden)

    Kate Vandyke

    2007-04-01

    Full Text Available Few treatment options exist for metastatic prostate cancer (PC that becomes hormone refractory (HRPC. In vitro, plant-derived MINA-05 caused dose-dependent decreases in cell numbers in HRPC cell lines LNCaPC4-2B and PC-3, and in androgen-sensitive LNCaP-FGC, DuCaP, and LAPC-4, by WST-1 assay. MINA-05 pretreatment significantly decreased clonogenic survival in agar and on plastic at 1 × and 2 × IC50 for PC-3 (P < .05 and P < .001, respectively, and at 1/2 ×, 1 ×, and 2 × IC50 for LNCaP-FGC cells (P < .001. MINA-05 also induced G2M arrest of LNCaP-FGC and PC-3 cells (by flow cytometry and caused some apoptosis in LNCaPFGC (sub-G1, peak on flow, expression of activated caspase-3 but not in PC-3 cells. Western blotting indicated that these cell cycle changes were associated with decreased levels of regulatory proteins cyclin B1 and cdc25C. MINA-05 given daily by gavage for 39 days did not diminish primary orthotopic PC-3 growth in nude mice, but decreased the extent of lymph node invasion at higher doses. We conclude that MINA-05 induces G2M arrest, inhibits cell growth, reduces PC cell re-growth in vitro, and reduces lymph node invasion after orthotopic PC-3 cell implantation in vivo. It has potential as an adjuvant treatment for patients with PC.

  11. Simultaneous catabolism of plant-derived aromatic compounds results in enhanced growth for members of the Roseobacter lineage.

    Science.gov (United States)

    Gulvik, Christopher A; Buchan, Alison

    2013-06-01

    Plant-derived aromatic compounds are important components of the dissolved organic carbon pool in coastal salt marshes, and their mineralization by resident bacteria contributes to carbon cycling in these systems. Members of the roseobacter lineage of marine bacteria are abundant in coastal salt marshes, and several characterized strains, including Sagittula stellata E-37, utilize aromatic compounds as primary growth substrates. The genome sequence of S. stellata contains multiple, potentially competing, aerobic ring-cleaving pathways. Preferential hierarchies in substrate utilization and complex transcriptional regulation have been demonstrated to be the norm in many soil bacteria that also contain multiple ring-cleaving pathways. The purpose of this study was to ascertain whether substrate preference exists in S. stellata when the organism is provided a mixture of aromatic compounds that proceed through different ring-cleaving pathways. We focused on the protocatechuate (pca) and the aerobic benzoyl coenzyme A (box) pathways and the substrates known to proceed through them, p-hydroxybenzoate (POB) and benzoate, respectively. When these two substrates were provided at nonlimiting carbon concentrations, temporal patterns of cell density, gene transcript abundance, enzyme activity, and substrate concentrations indicated that S. stellata simultaneously catabolized both substrates. Furthermore, enhanced growth rates were observed when S. stellata was provided both compounds simultaneously compared to the rates of cells grown singly with an equimolar concentration of either substrate alone. This simultaneous-catabolism phenotype was also demonstrated in another lineage member, Ruegeria pomeroyi DSS-3. These findings challenge the paradigm of sequential aromatic catabolism reported for soil bacteria and contribute to the growing body of physiological evidence demonstrating the metabolic versatility of roseobacters.

  12. Present and future potential of plant-derived products to control arthropods of veterinary and medical significance

    Science.gov (United States)

    2014-01-01

    The use of synthetic pesticides and repellents to target pests of veterinary and medical significance is becoming increasingly problematic. One alternative approach employs the bioactive attributes of plant-derived products (PDPs). These are particularly attractive on the grounds of low mammalian toxicity, short environmental persistence and complex chemistries that should limit development of pest resistance against them. Several pesticides and repellents based on PDPs are already available, and in some cases widely utilised, in modern pest management. Many more have a long history of traditional use in poorer areas of the globe where access to synthetic pesticides is often limited. Preliminary studies support that PDPs could be more widely used to target numerous medical and veterinary pests, with modes of action often specific to invertebrates. Though their current and future potential appears significant, development and deployment of PDPs to target veterinary and medical pests is not without issue. Variable efficacy is widely recognised as a restraint to PDPs for pest control. Identifying and developing natural bioactive PDP components in place of chemically less-stable raw or 'whole’ products seems to be the most popular solution to this problem. A limited residual activity, often due to photosensitivity or high volatility, is a further drawback in some cases (though potentially advantageous in others). Nevertheless, encapsulation technologies and other slow-release mechanisms offer strong potential to improve residual activity where needed. The current review provides a summary of existing use and future potential of PDPs against ectoparasites of veterinary and medical significance. Four main types of PDP are considered (pyrethrum, neem, essential oils and plant extracts) for their pesticidal, growth regulating and repellent or deterrent properties. An overview of existing use and research for each is provided, with direction to more extensive reviews

  13. Preclinical and first-in-human evaluation of PRX-105, a PEGylated, plant-derived, recombinant human acetylcholinesterase-R.

    Science.gov (United States)

    Atsmon, Jacob; Brill-Almon, Einat; Nadri-Shay, Carmit; Chertkoff, Raul; Alon, Sari; Shaikevich, Dimitri; Volokhov, Inna; Haim, Kirsten Y; Bartfeld, Daniel; Shulman, Avidor; Ruderfer, Ilya; Ben-Moshe, Tehila; Shilovitzky, Orit; Soreq, Hermona; Shaaltiel, Yoseph

    2015-09-15

    PRX-105 is a plant-derived recombinant version of the human 'read-through' acetylcholinesterase splice variant (AChE-R). Its active site structure is similar to that of the synaptic variant, and it displays the same affinity towards organophosphorus (OP) compounds. As such, PRX-105 may serve as a bio-scavenger for OP pesticides and chemical warfare agents. To assess its potential use in prophylaxis and treatment of OP poisoning we conducted several preliminary tests, reported in this paper. Intravenous (IV) PRX-105 was administered to mice either before or after exposure to an OP toxin. All mice who received an IV dose of 50nmol/kg PRX-105, 2min before being exposed to 1.33×LD50 and 1.5×LD50 of toxin and 10min after exposure to 1.5×LD50 survived. The pharmacokinetic and toxicity profiles of PRX-105 were evaluated in mice and mini-pigs. Following single and multiple IV doses (50 to 200mg/kg) no deaths occurred and no significant laboratory and histopathological changes were observed. The overall elimination half-life (t½) in mice was 994 (±173) min. Additionally, a first-in-human study, to assess the safety, tolerability and pharmacokinetics of the compound, was conducted in healthy volunteers. The t½ in humans was substantially longer than in mice (average 26.7h). Despite the small number of animals and human subjects who were assessed, the fact that PRX-105 exerts a protective and therapeutic effect following exposure to lethal doses of OP, its favorable safety profile and its relatively long half-life, renders it a promising candidate for treatment and prophylaxis against OP poisoning and warrants further investigation.

  14. NKS/SOS-1 Seminar on Safety analysis. Report from a seminar held on 22-23 March 2000 Risø National Laboratory, Roskilde, DK

    DEFF Research Database (Denmark)

    The report describes presentations and discussions at a seminar held at Risø on March 22-23, 2000. The title of the seminar was NKS/SOS-1 – Safety Analysis. It dealt with issues of relevance for the safety analysis for the entire nuclear safety field (notably reactors and nuclear waste repositories...

  15. Romanistik ohne Latein? Zu einer Empfehlung der Konferenz der Romanischen Seminare (Romance Studies without Latin? On a Recommendation from the Conference of Romance Seminars)

    Science.gov (United States)

    Neumeister, Sebastian

    1973-01-01

    Reaction to a February 19, 1972 recommendation of the Konferenz der Romanischen Seminare der Bundesrepublik Deutschland und West-Berlins in Deutschen Romanistenverband'' (Conference of Romance Seminars of the Federal Republic of Germany and West Berlin of the German Association of Romance Philologists) to discontinue the Latin prerequisite for…

  16. MANAGEMENT & COMMUNICATION: Programme of Seminars September to December 2003

    CERN Multimedia

    2003-01-01

    If you wish to participate in one of the following courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at: http://www.cern.ch/Training/ or fill in an "application for training" form available from your Divisional Secretariat or from your DTO (Divisional Training Officer). Applications will be accepted in the order of their receipt. MANAGEMENT & COMMUNICATION Nathalie Dumeaux tel. 78144 management.communication@cern.ch Situation : 13.10.2003 Dates Days Places Available Bilingual seminars Interpersonal Communication (Module 1-CM) 21, 22, 23 October 3 non* Managing a CERN unit - to be a Manager (Module 2) 28, 29 October 2 non Quality Management 10, 11, 12 November 3 oui Managing a CERN unit - to be a Manager (Module 3) 11, 12 November 2 non Risk Management 11, 12 December 2 oui Seminars In English Communicating Effectively (first part) 12, 13 November & 4...

  17. Management & communication: Programme of Seminars October to December 2004

    CERN Multimedia

    Nathalie Dumeaux

    2004-01-01

    If you wish to participate in one of the following courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at: http://www.cern.ch/Training/ or fill in an 'application for training' form available from your Divisional Secretariat or from your DTO (Divisional Training Officer). Applications will be accepted in the order of their receipt. Situation : 11.10.2004 Bilingual seminar Dates Days Places available Communication Techniques - 1 20, 21, 22 October 3 oui Quality Management 8, 9 November 2 oui Risk Management 6, 7 December 2 oui Project Management - Case Study 22 November 1 oui Seminars in English Communicating effectively in your team 14, 15 October 2 yes Performance Appraisal - MAPS 24, 25, 26 November 3 yes Performance Appraisal - MAPS 8, 9, 10 December 3 yes Séminaires en Français Appréciation des performances - MAPS 1, 2, 3 d&eacut...

  18. Einstein, 1905-2005 : Poincaré seminar

    CERN Document Server

    Darrigol, Olivier; Duplantier, B; Rivasseau, Vincent; Einstein 1905-2005 : séminaire Poincaré

    2006-01-01

    The Poincaré Seminar is held twice a year at the Institute Henri Poincaré in Paris. The goal of this seminar is to provide up-to-date information about general topics of great interest in physics. Both the theoretical and experimental results are covered, with some historical background. Particular care is devoted to the pedagogical nature of the presentation. This volume is devoted to Einstein's 1905 papers and their legacy. After a presentation of Einstein's epistemological approach to physics, and the genesis of special relativity, a centenary perspective is offered. The geometry of relativistic spacetime is explained in detail. Single photon experiments are presented, as a spectacular realization of Einstein's light quanta hypothesis. A previously unpublished lecture by Einstein, which presents an illuminating point of view on statistical physics in 1910, at the dawn of quantum mechanics, is reproduced. The volume ends with an essay on the historical, physical and mathematical aspects of Brownian motion...

  19. Management & Communication: Programme of Seminars January to March 2004

    CERN Document Server

    2004-01-01

    If you wish to participate in one of the following courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at: http://www.cern.ch/Training/ or fill in an "application for training" form available from your Divisional Secretariat or from your DTO (Divisional Training Officer). Applications will be accepted in the order of their receipt. MANAGEMENT & COMMUNICATION Nathalie Dumeaux tel. 78144 management.communication@cern.ch Situation : 20.01.2004 DatesDaysPlaces Available** Bilingual seminars Communication Techniques-1/Techniques de communication-1 16, 17, 18 March 3 non Project Management/Gestion de projet 17, 18, 19 March 3 oui Seminars in English Communicating effectively 22, 23 January & 19, 20 February 4 yes Performance Appraisal MAPS 4, 5, 6 February 3 yes Performance Appraisal -MAPS 11, 12, 13 February 3 yes Séminaires en Français Formation à l'entreti...

  20. Cryogenic Safety HSE Seminar | 21 - 23 September 2016

    CERN Multimedia

    2016-01-01

    With the LHC being the world’s largest superconducting installation, it’s not surprising that CERN is a world leader in cryogenic safety. On 21 and 22 September, over 100 experts in cryogenic safety will be coming to CERN to take part in CERN’s first Cryogenic Safety Seminar, which aims to stimulate collaboration and further the state of the art in this increasingly important field.  

  1. US-Swedish Seminar on Function Spaces and Applications

    CERN Document Server

    Peetre, Jaak; Sagher, Yoram; Wallin, Hans

    1988-01-01

    This seminar is a loose continuation of two previous conferences held in Lund (1982, 1983), mainly devoted to interpolation spaces, which resulted in the publication of the Lecture Notes in Mathematics Vol. 1070. This explains the bias towards that subject. The idea this time was, however, to bring together mathematicians also from other related areas of analysis. To emphasize the historical roots of the subject, the collection is preceded by a lecture on the life of Marcel Riesz.

  2. Effects of Koto Performance Seminar on Music Teacher Training

    OpenAIRE

    伊藤, 真; 平山, 裕基

    2017-01-01

    Music teachers need to have wide range of knowledge and teaching skills. This includes knowledge of world music such as Japanese traditional music, methods of instruction and performance skill. The department of Music Culture Education in Hiroshima University provides a variety of lectures and seminars on Japanese traditional music as a part of music teacher training, of which playing the koto (a long Japanese zither with 13 strings) is especially stressed as a continuous learning opportunity...

  3. Computer Science in Sport - Special emphasis: Football (Dagstuhl Seminar 11271)

    OpenAIRE

    Lames, Martin; McGarry, Tim; Nebel, Bernhard; Roemer, Karen

    2011-01-01

    This report documents the program and the outcomes of Dagstuhl Seminar 11271 ``Computer Science in Sport - Special emphasis: Football''. There were five sessions over the course of three days focusing on separate specific aspects on the relevance, applications and current issues pertaining to computer science in sport. The first session on the first day was about RoboCup -- the history, types of games and robots used, and the current topics relevant to machine learning, tracking and pla...

  4. Interaktiivse filmi näitus ja seminar Tartus

    Index Scriptorium Estoniae

    2004-01-01

    12. II viidi TÜ raamatukogus läbi Chris Halesi (Inglismaa) ja Teijo Pellineni (Soome) juhtimisel show "Cause and Effect". 13. II Tartu Kunstimajas seminar "Interaktiivne narratiiv ja digitaalne film", kus esinevad Chris Hales, Morten Schjudt (Taani) ja Klaas Kuitenbrouwer (Holland). Korraldaja: Tartu Kõrgema Kunstikooli meedia- ja reklaamikunsti osakond. Avatakse kõrgema kunstikooli üliõpilaste interaktiivse filmi projektide näitus "In-Cinema"

  5. EAPD interim seminar and workshop in Brussels May 9 2015

    OpenAIRE

    van Loveren, C.; van Palenstein Helderman, W.

    2016-01-01

    Aim This was to collect information for the 9th European Academy of Paediatric Dentistry Interim Seminar and Workshops to discuss the state of art on non-invasive caries therapy to be used if possible to formulate clinical guidelines by European experts in paediatric dentistry Methods Based on systematic reviews and additional papers were assessed for methods to prevent caries initiation and caries progression both in the state of pre-cavitation and cavitation without invasive technologies. R...

  6. Interaktiivse filmi näitus ja seminar Tartus

    Index Scriptorium Estoniae

    2004-01-01

    12. II viidi TÜ raamatukogus läbi Chris Halesi (Inglismaa) ja Teijo Pellineni (Soome) juhtimisel show "Cause and Effect". 13. II Tartu Kunstimajas seminar "Interaktiivne narratiiv ja digitaalne film", kus esinevad Chris Hales, Morten Schjudt (Taani) ja Klaas Kuitenbrouwer (Holland). Korraldaja: Tartu Kõrgema Kunstikooli meedia- ja reklaamikunsti osakond. Avatakse kõrgema kunstikooli üliõpilaste interaktiivse filmi projektide näitus "In-Cinema"

  7. [The value of mandatory seminars in the education of pre-registration house officers

    DEFF Research Database (Denmark)

    Henriksen, A.H.; Ringsted, C.; Pedersen-Reng, S.

    2008-01-01

    INTRODUCTION: There are advantages and disadvantages of general mandatory seminars in the education of pre-registration house officers. The seminars are highly rated by the pre-registration house officers, but we do not know what value they represent for the pre-registration house officers. The aim...... of this study was to explore this further. MATERIALS AND METHODS: Four focus group interviews with five junior doctors were conducted. Three themes were discussed: the advantages of the seminars, the disadvantages of the seminars and the needs or wishes concerning both the seminars and education generally...... and require feedback and supervision. CONCLUSION: The results reflect the pre-registration house officers' social needs and need for tools to manage complex situations and their need for recognition. The value of the seminars must be seen in terms of facilitating and supporting the development of both...

  8. Management & Communication: Programme of Seminars September to December 2004

    CERN Multimedia

    Nathalie Dumeaux

    2004-01-01

    Situation : 13.07.2004 Bilingual seminars Dates Days Places Available Project Management 13, 14, 15 September 3 oui Introduction to Management 20, 21, 22 September 3 oui Managing by project 28, 29 September 2 oui Project Management Case study 8 October 1 oui Communication Techniques - 1 20, 21, 22 October 3 oui Quality Management 8, 9 November 2 oui Risk Management 6, 7 December 2 oui Seminars in English Communicating effectively 20 September, 1 october + 2, 3 November 4 yes Communicating effectively in your team 14, 15 October 2 yes Séminaires en Français Communiquer efficacement 21, 22 septembre + 12, 13 octobre 4 oui Techniques d'exposé et de présentation 27, 28 septembre + 18 octobre 3 oui Animer ou participer à une réunion de travail 15, 16, 17 novembre 3 oui * If you are interested in a seminar where there are no places available, please fill in an application form and we will contact you as soon as a new session is organised. MANAGEMENT & COMMUNICA...

  9. Engineering Integration: Building a Quick and Effective Faculty Seminar

    Directory of Open Access Journals (Sweden)

    Kate Peterson

    2012-12-01

    Full Text Available In the spring of 2010, the Science & Engineering Library of the University of Minnesota-Twin Cities partnered with the Information Literacy Librarian and offered a faculty seminar to the College of Science and Engineering. The seminar’s goals included 1. refreshing and expanding faculty’s knowledge of information and 21st century literacies and 2. creating a community of faculty committed to developing student skills in finding, evaluating and synthesizing information in their academic coursework and into their professional careers. Overall, the seminar increased faculty understanding of services and expertise of the libraries, and 21st century literacies. It also developed and strengthened ties between individual faculty members and their subject librarians, leading to a mix of outcomes from a faculty member partnering on a grant the Libraries applied for to course integrated instruction sessions to faculty participating in an e-textbook pilot. This seminar provides a strong model for re-framing information literacy in the context of teaching and learning in science and engineering, giving librarians an opportunity to strengthen relationships and increase liaison effectiveness.

  10. Preparation for Retirement Seminar – A few places left

    CERN Multimedia

    2007-01-01

    There are a few places left for the preparation for retirement seminar, which will take place on the four successive afternoons of 2 to 5 October 2007. Staff concerned: All staff members aged 58 and above, as well as those who have retired during the year, who have been sent a personal invitation to attend. Spouses are welcome. Staff members below 58 who are interested in attending the seminar may also apply. Their applications will be accepted subject to availability of places. Registration: In view of the number of people concerned and the limited capacity of the Main Auditorium, you are requested to register in advance via Indico at the following address: http://indico.cern.ch/conferenceDisplay.py?confId=16835 You may register for all the sessions or only for the subjects of interest to you. If you envisage retiring in the coming two or three years, I strongly encourage you to register for this seminar. All related information is available on Indico. Enrico CHIAVERI H...

  11. Preparation for Retirement Seminar – A few places left

    CERN Multimedia

    2007-01-01

    There are a few places left for the preparation for retirement seminar, which will take place on the four successive afternoons of 2 to 5 October 2007. Staff concerned: All staff members aged 58 and above as well as those who have retired during the year have been sent a personal invitation to attend. Spouses are welcome. Staff members below 58 who are interested in attending the seminar may also apply. Their applications will be accepted subject to availability of places. Registration: In view of the number of people concerned and the limited capacity of the main auditorium, you are requested to register in advance via Indico at the following address: http://indico.cern.ch/conferenceDisplay.py?confId=16835 You may register for all the sessions or only for the subjects of interest to you. If you envisage retiring in the coming two or three years, I strongly encourage you to register for this seminar. All related information is available on Indico. Enrico CHIAVERI Head, H...

  12. Seminar 2.0: Learning With Skype and Video Podcasts

    Science.gov (United States)

    Wessel, Paul; Anderson, Tiffany; Austin, Regan; Benediktsdottir, Asdis; Chandler, Michael T.; Conley, Michaela M.; Kim, Seung-Sep; Michaud, Robert L.; Rumpf, M. Elise; Sleeper, Jonathan D.; Weiss, Jonathan R.

    2009-04-01

    Graduate seminars typically involve reviewing key papers, ranging from seminal contributions by pioneers to the latest cutting-edge results published in journals such as Nature, Science, and Geophysical Research Letters. Ideally, guest lecturers are invited to add specific expertise and stimulate discussions. However, the increasing costs for travel make this an expensive proposition. Recent improvements in free videoconferencing over the Internet make it possible to invite distant experts to participate in seminars without involving expensive and time-consuming travel. Tools to record video conferences allow anyone to combine narrations with slide presentations and prepare merged video files for distribution over the Internet (i.e., podcasts). This brief report discusses such an experiment in a graduate seminar on advanced plate tectonics in the Department of Geology and Geophysics at University of Hawai`i at Manoa's (UHM) School of Ocean and Earth Science and Technology (SOEST). The podcasts are freely available from iTunes (UHM; SOEST; Public Course Lectures) and from http://www.soest.hawaii.edu/pwessel/podcasts.

  13. Development and Sequential Analysis of a New Multi-Agent, Anti-Acne Formulation Based on Plant-Derived Antimicrobial and Anti-Inflammatory Compounds

    Science.gov (United States)

    Saviuc, Crina; Ciubucă, Bianca; Dincă, Gabriela; Bleotu, Coralia; Drumea, Veronica; Chifiriuc, Mariana-Carmen; Popa, Marcela; Gradisteanu Pircalabioru, Gratiela; Marutescu, Luminita; Lazăr, Veronica

    2017-01-01

    The antibacterial and anti-inflammatory potential of natural, plant-derived compounds has been reported in many studies. Emerging evidence indicates that plant-derived essential oils and/or their major compounds may represent a plausible alternative treatment for acne, a prevalent skin disorder in both adolescent and adult populations. Therefore, the purpose of this study was to develop and subsequently analyze the antimicrobial activity of a new multi-agent, synergic formulation based on plant-derived antimicrobial compounds (i.e., eugenol, β-pinene, eucalyptol, and limonene) and anti-inflammatory agents for potential use in the topical treatment of acne and other skin infections. The optimal antimicrobial combinations selected in this study were eugenol/β-pinene/salicylic acid and eugenol/β-pinene/2-phenoxyethanol/potassium sorbate. The possible mechanisms of action revealed by flow cytometry were cellular permeabilization and inhibition of efflux pumps activity induced by concentrations corresponding to sub-minimal inhibitory (sub-MIC) values. The most active antimicrobial combination represented by salycilic acid/eugenol/β-pinene/2-phenoxyethanol/potassium sorbate was included in a cream base, which demonstrated thermodynamic stability and optimum microbiological characteristics. PMID:28106736

  14. Effect of addition of plants-derived polyamide 11 elastomer on the mechanical and tribological properties of hemp fiber reinforced polyamide 1010 composites

    Science.gov (United States)

    Mukaida, Jun; Nishitani, Yosuke; Kitano, Takeshi

    2015-05-01

    For the purpose of developing the new engineering materials such as structural materials and tribomaterials based on all plants-derived materials, the effect of the addition of plant-derived polyamide 11 Elastomer (PA11E) on the mechanical and tribological properties of hemp fiber(HF) reinforced polyamide 1010 (HF/PA1010) composites was investigated. PA1010 and PA11E (except the polyether groups used as soft segment) were made from plant-derived castor oil. Hemp fiber was surface-treated by two types of treatment: alkali treatment by NaOH solution and surface treatment by ureido silane coupling agent. HF/PA1010/PA11E ternary composites were extruded by a twin screw extruder and injection-molded. Their mechanical properties such as tensile, bending, Izod impact and tribological properties by ring-on-plate type sliding wear testing were evaluated. The effect of the addition of PA11E on the mechanical and tribological properties of HF/PA1010 composite differed for each property. Izod impact strength and specific wear rate improved with the addition of PA11E although tensile strength, modulus, and friction coefficient decreased with PA11E. It follows from these results that it may be possible to develop the new engineering materials with sufficient balance between mechanical and tribological properties.

  15. Development and Sequential Analysis of a New Multi-Agent, Anti-Acne Formulation Based on Plant-Derived Antimicrobial and Anti-Inflammatory Compounds

    Directory of Open Access Journals (Sweden)

    Crina Saviuc

    2017-01-01

    Full Text Available The antibacterial and anti-inflammatory potential of natural, plant-derived compounds has been reported in many studies. Emerging evidence indicates that plant-derived essential oils and/or their major compounds may represent a plausible alternative treatment for acne, a prevalent skin disorder in both adolescent and adult populations. Therefore, the purpose of this study was to develop and subsequently analyze the antimicrobial activity of a new multi-agent, synergic formulation based on plant-derived antimicrobial compounds (i.e., eugenol, β-pinene, eucalyptol, and limonene and anti-inflammatory agents for potential use in the topical treatment of acne and other skin infections. The optimal antimicrobial combinations selected in this study were eugenol/β-pinene/salicylic acid and eugenol/β-pinene/2-phenoxyethanol/potassium sorbate. The possible mechanisms of action revealed by flow cytometry were cellular permeabilization and inhibition of efflux pumps activity induced by concentrations corresponding to sub-minimal inhibitory (sub-MIC values. The most active antimicrobial combination represented by salycilic acid/eugenol/β-pinene/2-phenoxyethanol/potassium sorbate was included in a cream base, which demonstrated thermodynamic stability and optimum microbiological characteristics.

  16. 2011 Photosynthesis Gordon Research Conference & Seminar (June 11-17, 2011, Davidson College, Davidson, North Carolina)

    Energy Technology Data Exchange (ETDEWEB)

    Prof. Krishna Niyogi

    2011-06-17

    Photosynthesis is the biological process that converts solar energy into chemical energy. Elucidation of the mechanisms of photosynthetic energy conversion at a molecular level is fundamentally important for understanding the biology of photosynthetic organisms, for optimizing biological solar fuels production, and for developing biologically inspired approaches to solar energy conversion. The 2011 Gordon Conference on Photosynthesis will present cutting-edge research focusing on the biochemical aspects of photosynthesis, including: (1) structure, assembly, and function of photosynthetic complexes; (2) the mechanism of water splitting by PSII; (3) light harvesting and quenching; (4) alternative electron transport pathways; (5) biosynthesis of pigments and cofactors; and (6) improvement of photosynthesis for bioenergy and food production. Reflecting the interdisciplinary nature of photosynthesis research, a diverse group of invited speakers will represent a variety of scientific approaches to investigate photosynthesis, such as biochemistry, molecular genetics, structural biology, systems biology, and spectroscopy. Highly interactive poster sessions provide opportunities for graduate students and postdocs to present their work and exchange ideas with leaders in the field. One of the highlights of the Conference is a session featuring short talks by junior investigators selected from the poster presentations. The collegial atmosphere of the Photosynthesis GRC, with programmed discussion sessions as well as informal gatherings in the afternoons and evenings, enables participants to brainstorm, exchange ideas, and forge new collaborations. For the second time, this Conference will be immediately preceded by a Gordon Research Seminar on Photosynthesis (June 11-12, 2011, at the same location), with a focus on 'Photosynthesis, Bioenergy, and the Environment.' The GRS provides an additional opportunity for graduate students and postdocs to present their research

  17. Climate technology initiative capacity building seminar: best practice in climate technology and energy efficiency in central and eastern Europe. Seminar Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Pichl, P. [ed.

    2000-08-01

    The Capacity Building Seminar on 'Best Practice in Climate Technology and Energy Efficiency in Central and Eastern Europe', held 6-10 December 1999 in Marienthal/Ostritz in Germany, was a very successful event in the framework of the CLIMATE TECHNOLOGY INITIATIVE (CTI). One reason for that is that the seminar allowed delegates from 22 nations, from Kazakhstan to Estonia, come together for an exchange of opinions about 'Energy Efficiency and Climate Protection' and all related issues. A reason is that this seminar provided an excellent starting point for future networking in Central and Eastern Europe and Asia. The colleagues who got to know each other at the seminar will meet again in future workshops and seminars. They can now contact a colleague from abroad to get information about special questions of Energy Efficiency when they need it. A third reason - and the most important one for the entire co-operation within the CTI organisation - is the special character of the seminar as a starting point for multitude of activities on Energy Efficiency and Climate Protection. At the end of the Ostritz seminar eleven delegations stated that they would organise follow up workshops in their own countries to go deeper into the details and to co-operate on a higher level. It may be that these workshops will be followed by others in other European regions. (orig./GL)

  18. A May American Economic Review Papers Seminar and an Analytic Project for Advanced Undergraduates

    Science.gov (United States)

    Elliott, Catherine S.

    2004-01-01

    The author describes two learning activities for teaching economics at the advanced undergraduate level: a May American Economic Review (AER) papers seminar and an analytic project. Both activities help students learn to "do economics." The May AER papers seminar promotes in-depth synthesis and interpretation on the basis of printed session papers…

  19. Psychopathology and causal explanation in practice. A critical note on Heidegger's Zollikon Seminars

    NARCIS (Netherlands)

    Meynen, G.; Verburgt, J.H.P.

    2009-01-01

    From 1959 until 1969, Heidegger lectured to psychiatrists and psychiatry students at the University of Zurich Psychiatric Clinic and in Zollikon. The transcriptions of these lectures were published as the Zollikon Seminars. In these seminars Heidegger is highly critical of psychoanalysis, because of

  20. State Education & Environment Roundtable (SEER) Seminar (10th, Annapolis, Maryland, December 3-7, 2000).

    Science.gov (United States)

    Lieberman, Gerald A.; Hoody, Linda L.

    This document reports on the 10th seminar of the State Education and Environment Roundtable (SEER). It consists of brief overviews of the daily discussions and presentations that were made at the seminar. Topics discussed include measuring success through student assessment, the Bay Schools Project (BSP), and a co-sponsored educational forum with…

  1. State Education & Environment Roundtable (SEER) Seminar (9th, San Diego, California, May 21-25, 2000).

    Science.gov (United States)

    Lieberman, Gerald A.; Hoody, Linda L.

    This document reports on the 9th seminar of the State Education and Environment Roundtable (SEER). It consists of brief overviews of the daily discussions and presentations that were made at the seminar. Topics discussed include connecting service learning and the Environment as an Integrated Context for learning (EIC), and reports from states on…

  2. State Education & Environment Roundtable (SEER) Seminar (11th, Des Moines, Iowa, May 20-24, 2001).

    Science.gov (United States)

    Lieberman, Gerald A.; Hoody, Linda L.

    This document reports on the 11th seminar of the State Education and Environment Roundtable (SEER). It consists of brief overviews of the daily discussions and presentations that were made at the seminar. Topics discussed include potential partnerships with national language arts organizations and associations, how environmental justice issues…

  3. Analysis, Test and Verification in The Presence of Variability (Dagstuhl Seminar 13091)

    DEFF Research Database (Denmark)

    2014-01-01

    This report documents the program and the outcomes of Dagstuhl Seminar 13091 “Analysis, Test and Verification in The Presence of Variability”. The seminar had the goal of consolidating and stimulating research on analysis of software models with variability, enabling the design of variability-awa...

  4. Writing Seminars in the Content Area: In Search of Hemingway, Salinger, and Steinbeck.

    Science.gov (United States)

    Workman, Brooke

    Intended for high school and college literature instructors, this book contains materials for intensive semester-long seminars on the lives and works of three American authors: Ernest Hemingway, J. D. Salinger, and John Steinbeck. Each seminar revolves around seven papers the students are required to write and defend aloud in front of the rest of…

  5. The Influence of a Collaborative Doctoral Seminar on Emerging Teacher Educator-Researchers

    Science.gov (United States)

    Dinkelman, Todd; Cuenca, Alexandar; Butler, Brandon; Elfer, Charles; Ritter, Jason; Powell, Dave; Hawley, Todd

    2012-01-01

    Over a 7-year period, graduate teaching assistants participated in a teacher education doctoral seminar designed to develop emergent scholarship and practice in teacher education. Six former students in the seminar, all now assistant professors, joined Dinkelman in an open-ended, far-ranging, month-long conversation captured in a threaded, online…

  6. Environmental Education Research. Seminar Report (London, England, United Kingdom, December 3, 1991).

    Science.gov (United States)

    Council for Environmental Education, London (England).

    The seminar aimed to improve the degree and quality of Environmental Education Research (EER) in the context of global environmental change with particular emphasis on the role of the social sciences. The report is divided into six sections and appendices. Section 1, an introduction, includes the seminar background, aim, objectives, and chair's…

  7. Virtual seminar room-modelling and experimentation in horizontal and vertical integration

    DEFF Research Database (Denmark)

    Forchhammer, Søren; Fosgerau, Anders; Hansen, Peter Søren Kirk;

    1999-01-01

    The initial design considerations and research goals for an ATM network based virtual seminar room with five sites are presented. The basic observation behind the design of the virtual seminar room is, that besides the constant growth in available bandwidth for transmission in communication netwo...... the applications to provide, in a broad sense, a high and reliable quality presented at the human computer interface...

  8. The 11th Seminar of the International Association for Tibetan Studies held in Bonn, Germany

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ The Eleventh Seminar of the IATS was held from 27th August-2nd September 2006 in K?nigswinter near Bonn of Germany. The sponsor of the Seminar was IATS and the convenor was the Institut für rientund Asienwissenschaften der Universit?t Bonn, Germany.

  9. Student Teaching Seminars: Ideas for a Collaborative and Meaningful Culminating Experience

    Science.gov (United States)

    Councill, Kimberly H.; Baumgartner, Christopher M.

    2017-01-01

    The student teaching seminar is a crucial component in the final course work of the music education curriculum, though research that examines the structure and content of this important course is minimal. In this article, we provide in-depth descriptions of sample seminar activities, assessments, resources, and suggestions for creating a…

  10. Complexity Theory 101 for Educators: A Fictional Account of a Graduate Seminar

    Science.gov (United States)

    McMurtry, Angus

    2008-01-01

    The following fictional account of a seminar on complexity science and its relevance for education makes use of several real events. The first is an actual seminar that took place during the spring of 2005, in the Department of Secondary Education at the University of Alberta. The second is the collective creation of the Complexity and Education…

  11. IACTalks: an on-line archive of astronomy-related seminars

    DEFF Research Database (Denmark)

    Knapen, Johan H.; Pérez Prieto, Jorge A.; Shahbaz, Tariq

    2012-01-01

    Canarias goes back to 2008. Over 360 talks and seminars are now freely available by streaming over the internet. We describe the user interface, which includes two video streams, one showing the speaker, the other the presentation. A search function is available, and seminars are indexed by keywords...

  12. Report of the EEA Scientific Committee. Seminar on Environment, Human Health and Well-Being

    DEFF Research Database (Denmark)

    van denHove, Sybille; Martin, Jock; Jarosinska, Dorota

    This report provides a summary of discussion at the European Environment Agency’s Scientific Committee Seminar on 12 February 2014 in Copenhagen.......This report provides a summary of discussion at the European Environment Agency’s Scientific Committee Seminar on 12 February 2014 in Copenhagen....

  13. Arbejdsmiljøseminarer som en metode til at skabe motivation, ansvar og ejerskab til sikkerhedsarbejdet

    DEFF Research Database (Denmark)

    Pedersen, Louise

    2011-01-01

    arbejdsmiljøseminarer som en ny metode til på en meningsfuld måde systematisk at involvere mellemlederne og de ansatte i virksomhedernes sikkerhedsarbejde og dermed potentielt at fremme deres motivation, ansvar og ejerskab til dette. Arbejdsmiljøseminarer tager udgangspunkt i de ansattes faglige ekspertise og...

  14. The Seminar Practicum: A Community Based Instructional System for Paraprofessional Education.

    Science.gov (United States)

    Powers, Thomas F.; And Others

    The instructional system which emerged from the Pennsylvania State University three-year project was a seminar practicum for Hotel and Food Service paraprofessional workers which provides work experience, a set of self-instructional modules, subject matter, a weekly seminar discussion, and encourages minority/lower income students. A summary of…

  15. The "Other" Syllabus: Rendering Teaching Politics Visible in the Graduate Pedagogy Seminar

    Science.gov (United States)

    Bailey, Lucy E.

    2010-01-01

    The author has explored the pedagogical possibilities of exploring doubt and ambiguity in graduate seminars in feminist pedagogy and teaching methods that she has been responsible for leading in several large public university settings. In these settings, faculty instituted the seminars in the graduate curriculum because they recognized the…

  16. 48 CFR 2452.222-70 - Accessibility of meetings, conferences, and seminars to persons with disabilities.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Accessibility of meetings, conferences, and seminars to persons with disabilities. 2452.222-70 Section 2452.222-70 Federal Acquisition... (e.g., sign language interpreters) for each meeting, conference, or seminar in light of the known...

  17. Psychopathology and causal explanation in practice. A critical note on Heidegger's Zollikon Seminars

    NARCIS (Netherlands)

    Meynen, G.; Verburgt, J.H.P.

    2009-01-01

    From 1959 until 1969, Heidegger lectured to psychiatrists and psychiatry students at the University of Zurich Psychiatric Clinic and in Zollikon. The transcriptions of these lectures were published as the Zollikon Seminars. In these seminars Heidegger is highly critical of psychoanalysis, because of

  18. Final report. CIRP seminar on micro and nano technology. November 2003

    DEFF Research Database (Denmark)

    Hansen, Hans Nørgaard; Alting, Leo

    This final reports contains a description of the 1st international CIRP seminar on micro and nano technology held at DTU in November 2003.......This final reports contains a description of the 1st international CIRP seminar on micro and nano technology held at DTU in November 2003....

  19. The Swedish electric and hybrid vehicle R, D and D program. Seminar no. 2, June 1999

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-09-01

    This publication presents a selection of the ongoing and finalised projects in form of abstracts, within the KFB RDD-program Electric- and Hybride Vehicles. These projects were presented at the second project manager seminar 14-15 June 1999. The first project manager seminar was held 20-21 October 1998

  20. Internationalizing the Business Curriculum at Small Colleges: The Introductory Seminar Approach.

    Science.gov (United States)

    Greenfield, Gerald Michael

    The University of Wisconsin-Parkside offered an experimental course on international business in seminar form as a means of trying an interdisciplinary venture in a new area without commitment to a course structure. The seminar was developed as part of the international studies program, which draws on existing courses in several disciplines, and…

  1. Formative Evaluation of the Intel Seeing Reason Seminars (U.S.). Summary Report

    Science.gov (United States)

    Wexler, Dara; Culp, Katie McMillan

    2004-01-01

    During the summer and fall of 2003, Education Development Center's Center for Children and Technology (CCT) undertook a formative evaluation of Seeing Reason: Mindful Mapping of Cause & Effect, an Intel Teach to the Future professional development seminar. Intel's seminars are designed to introduce teachers to software tools that they can use to…

  2. Network attack detection and defense: securing industrial control systems for critical infrastructures (Dagstuhl Seminar 14292)

    NARCIS (Netherlands)

    Dacer, Marc; Kargl, Frank; König, Hartmut; Valdes, Alfonso

    2014-01-01

    This report documents the program and the outcomes of Dagstuhl Seminar 14292 “Network Attack Detection and Defense: Securing Industrial Control Systems for Critical Infrastructures”. The main objective of the seminar was to discuss new approaches and ideas for securing industrial control systems. It

  3. Critical Conversations about Big Ideas in Art Using Paideia Seminar: A Focus on Early Elementary Settings

    Science.gov (United States)

    Paul, Kristina Ayers; Tay, Juliana

    2016-01-01

    Paideia Seminar is a method for facilitating Socratic discussions about different types of texts, whether they be texts in the literal sense of the word or any other object that represents ideas or values. In this article, we describe how teachers can implement Paideia Seminar to spark deep thinking and rich discussion among early elementary…

  4. Educational Programming: A Seminar for Young Adults with Cleft Lip and/or Palate.

    Science.gov (United States)

    Imhoff, Michael; And Others

    1981-01-01

    The social service staff of the H. K. Cooper Clinic (Lancaster, Pennsylvania) conducted a seminar for young adults with cleft lip and palate (CL/P) and their families. The seminar was designed to respond to questions and concerns regarding the impact of CL/P on employment, social relations, and genetics. (SB)

  5. Educational Programming: A Seminar for Young Adults with Cleft Lip and/or Palate.

    Science.gov (United States)

    Imhoff, Michael; And Others

    1981-01-01

    The social service staff of the H. K. Cooper Clinic (Lancaster, Pennsylvania) conducted a seminar for young adults with cleft lip and palate (CL/P) and their families. The seminar was designed to respond to questions and concerns regarding the impact of CL/P on employment, social relations, and genetics. (SB)

  6. Intellectual Curiosity in Action: A Framework to Assess First-Year Seminars in Liberal Arts Settings

    Science.gov (United States)

    Kolb, Kenneth H.; Longest, Kyle C.; Barnett, Jenna C.

    2014-01-01

    Fostering students' intellectual curiosity is a common goal of first-year seminar programs--especially in liberal arts settings. The authors propose an alternative method to assess this ambiguous, value-laden concept. Relying on data gathered from pre- and posttest in-depth interviews of 34 students enrolled in first-year seminars, they construct…

  7. Proceedings on the seminar on small hydroelectric installations: Practice report and current development; Beitraege zum Seminar Kleinwasserkraft: Praxis und aktuelle Entwicklung

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-12-31

    This seminar on small hydroelectric installations informs on aspects of construction and administrative aspects. But above all, questions of machinery are dealt with. The book gives an overview of turbine types, topical recent developments in the sector of small hydroelectric power stations, and modern opportunities for fast and inexpensive design of power station components. Beyond the discussion of technical issues, the seminar wants to further contacts between science, turbine manufacturers, consultants and plant operators. (orig.) [Deutsch] Das Seminar Kleinwasserkraft gibt eine Uebersicht ueber bauliche Gestaltung und behoerdliche Aspekte. Vorallem behandelt es aber maschinenbauliche Problemstellungen. Es zeigt einen Ueberblick ueber Turbinentypen, aktuelle Neuentwicklungen im Kleinwassersektor, sowie moderne Moeglichkeiten zum schnellen und preiswerten Design von Kraftwerkskomponenten. Neben dem technischen Teil dient das Seminar auch der Foerderung des Kontakts zwischen Wissenschaft, Turbinenherstellern, Consultants und Anlagenbetreibern. (orig.)

  8. Seminar in Critical Inquiry Twenty-first Century Nuclear Systems

    Energy Technology Data Exchange (ETDEWEB)

    LeMone, D. V.

    2002-02-25

    Critical Inquiry, has not only been successful in increasing university student retention rate but also in improving student academic performance beyond the initial year of transition into the University. The seminar course herein reviewed is a balanced combination of student personal and academic skill development combined with a solid background in modern nuclear systems. It is a valid premise to assume that entering students as well as stakeholders of the general public demonstrate equal levels of capability. Nuclear systems is designed to give a broad and basic knowledge of nuclear power, medical, industrial, research, and military systems (nuclear systems) in 20-25 hours.

  9. PREFACE: XV International Seminar on Physics and Chemistry of Solids

    Science.gov (United States)

    Kotur, Bogdan; Brągiel, Piotr

    2011-03-01

                      Logo     Logo The XV International Seminar on Physics and Chemistry of Solids (ISPCS15) was held from 7-10 June 2009 in Szklarska Poręba. Over eighty participants joined together in this mountain resort, at the foot of Szrenica peak, in the Polish part of the Sudety range. The majority or participants, in accordance with Seminar tradition, were from Ukraine and Poland. The pleasant and warm atmosphere created by the organizers was conducive to fruitful discussions, making new contacts and to joyful gatherings with friends. Even the rainy weather could not change that. Lectures and communications mainly covered the fields of solid state physics and chemistry, and possible applications. This time, however, a new section was introduced - one devoted to modern topics in liquid chemistry. Sometimes such a look over the borders of scientific specialties leads to interesting insights and original research solutions. Some of the papers presented during ISPCS15 are collected in this volume. Their diversity is representative of both the scope and character of this Seminar. The majority of the papers are research reports, but a review article and a paper focussed on problems connected with environmental protection are also included. This Conference has functioned for over a decade due to the permanent support of the rectors of both co-organizing universities: Professor Ivan Vakarchuk from Ivan Franko National University of Lviv and Professor Zygmunt Bąk from Jan Dlugosz University in Częstochowa. It is our pleasure, on behalf of the all participants of the past Seminars, to express our gratitude for this assistance. We would also like to thank all the invited speakers who kindly accepted our invitation, namely Professors Roman Gladyshevskii (Ivan Franko National University, Lviv, Ukraine), Mihaela Gulea (Laboratoire de Chimie Moleculare et Thioorganique, CAEN, France), Osama I Abd El-Salam (National Research

  10. The assessment of the level of knowledge and the use of plant-derived preparations among people reporting to the Rehabilitation Clinic in Lublin

    Directory of Open Access Journals (Sweden)

    Magdalena Amarowicz

    2015-05-01

    Full Text Available The use of plant-derived compounds in medicine arouses more and more interest. Most plants contain numerous active ingredients that may have therapeutic effects on the human body. For many years, herbs have been used as medicinal agents. However, it is necessary to learn about the chemical content of the plant as well as how they work on the human body. The aim of this study was to evaluate the use of preparations containing plant extracts and the assessment of respondents’ knowledge about plant resources with medicinal properties. The study group consisted of people who visited the Rehabilitation Department in Lublin. Respondents voluntarily filled out the questionnaire consisting of 21 questions. 33 persons were examined in total. More than 77% of those who participated in the study have ever applied preparations of plant origin. More than half rated their level of knowledge about medicinal plants as small. Respondents gained knowledge about data on herbs and herbal supplements from several sources. None of the respondents considers preparations containing plant extracts as fully safe for the body and no one would use it without consulting a doctor first. The majority of respondents (over 63% rated the effectiveness of the plant-derived compounds as good. Over 90% of respondents noticed positive effects of the use of plant supplements. Most respondents did not use compounds of plant origin which might slow down the body’s aging process or improve memory and concentration. However, more than half of the respondents applied preparations containing sedative plant extracts. As seen in the studies and the discussion above, the prevalence of the use of plant-derived compounds among respondents is relatively large. Respondents do not have sufficient knowledge of these substances. Almost all respondents notice the positive impact of plant compounds on the body. There is a need for educational campaigns among society to enrich the knowledge on the

  11. Teamwork Seminar Practice to Foster Diversified Thinking and Leadership Among Students

    Science.gov (United States)

    Maruyama, Naoki; Yoshida, Kazumi; Yamao, Hidenori

    A new course entitled “Mechanical Engineering Seminar” has begun in the Department of Mechanical Engineering, Mie University. This course consists of three parts, a teamwork seminar, a creative design seminar and a comprehensive achievement examination. Its aim is to foster a broad social and international outlook, ethical thinking, autonomy, partnership, leadership, presentation ability, originality, overall creativity in students, and to help them become aware of their real ability. The teaching method used in this seminar is based on problem-based learning (PBL) , and pro-active student participation is required. The purpose of this paper is to report the features, teaching method and educational effectiveness of the teamwork seminar, which seeks to educate students with a broad, diversified outlook. The results of a student questionnaire show that these new fields of study stimulate students' will to learn, and they express general satisfaction with the seminar.

  12. IACTalks: an on-line archive of astronomy-related seminars

    CERN Document Server

    Knapen, Johan H; Shahbaz, Tariq; Ferré-Mateu, Anna; Caon, Nicola; Almeida, Cristina Ramos; Tingley, Brandon; Luridiana, Valentina; Flores-Cacho, Inés; Creevey, Orlagh; Torres, Arturo Manchado; Trujillo, Ignacio; Osorio, Maria Rosa Zapatero; Martínez, Francisco Sánchez; Molina, Francisco López; Díaz, Gabriel Pérez; Briganti, Miguel; Bonet, Inés

    2012-01-01

    We present IACTalks, a free and open access seminars archive (http://iactalks.iac.es) aimed at promoting astronomy and the exchange of ideas by providing high-quality scientific seminars to the astronomical community. The archive of seminars and talks given at the Instituto de Astrofi\\'isica de Canarias goes back to 2008. Over 360 talks and seminars are now freely available by streaming over the internet. We describe the user interface, which includes two video streams, one showing the speaker, the other the presentation. A search function is available, and seminars are indexed by keywords and in some cases by series, such as special training courses or the 2011 Winter School of Astrophysics, on secular evolution of galaxies. The archive is made available as an open resource, to be used by scientists and the public.

  13. Gene Expression Response of Salmonella enterica Serotype Enteritidis Phage Type 8 to Subinhibitory Concentrations of the Plant-Derived Compounds Trans-Cinnamaldehyde and Eugenol

    Directory of Open Access Journals (Sweden)

    Anup Kollanoor Johny

    2017-09-01

    Full Text Available Background:Salmonella Enteritidis phage type 8 (PT8 is a major poultry-associated Salmonella strain implicated in foodborne outbreaks in the United States. We previously reported that two plant-derived compounds generally recognized as safe (GRAS, trans-cinnamaldehyde (TC, and eugenol (EG, significantly reduced S. Enteritidis colonization in broiler and layer chickens. To elucidate potential PT8 genes affected by TC and EG during colonization, a whole-genome microarray analysis of the bacterium treated with TC and EG was conducted.Results:S. Enteritidis PT8 was grown in Luria-Bertani broth at 37°C to an OD600 of ~0.5. Subinhibitory concentrations (SICs; concentration that does not inhibit bacterial growth of TC (0.01%; 0.75 mM or EG (0.04%; 2.46 mM were then added to the culture. S. Enteritidis PT8 RNA was extracted before and 30 min after TC or EG addition. Labeled cDNA from three replicate experiments was subsequently hybridized to a microarray of over 99% of S. Enteritidis PT4 genes, and the hybridization signals were quantified. The plant-derived compounds down-regulated (P < 0.005 expression of S. Enteritidis PT8 genes involved in flagellar motility, regulation of the Salmonella Pathogenicity Island 1, and invasion of intestinal epithelial cells. TC and EG also suppressed transcription of genes encoding multiple transport systems and outer membrane proteins. Moreover, several metabolic and biosynthetic pathways in the pathogen were down-regulated during exposure to the plant-derived compounds. Both TC and EG stimulated the transcription of heat shock genes, such as dnaK, dnaJ, ibpB, and ibpA in S. Enteritidis PT8 (P < 0.005. The results obtained from microarray were validated using a quantitative real-time PCR.Conclusion: The plant-derived compounds TC and EG exert antimicrobial effects on S. Enteritidis PT8 by affecting multiple genes, including those associated with virulence, colonization, cell membrane composition, and transport

  14. Effectiveness of modified seminars as a teaching-learning method in pharmacology

    Science.gov (United States)

    Palappallil, Dhanya Sasidharan; Sushama, Jitha; Ramnath, Sai Nathan

    2016-01-01

    Context: Student-led seminars (SLS) are adopted as a teaching-learning (T-L) method in pharmacology. Previous studies assessing the feedback on T-L methods in pharmacology points out that the traditional seminars consistently received poor feedbacks as they were not favorite among the students. Aims: This study aimed to obtain feedback on traditional SLS, introduce modified SLS and compare the modified seminars with the traditional ones. Settings and Design: This was a prospective interventional study done for 2 months in medical undergraduates of fifth semester attending Pharmacology seminars at a Government Medical College in South India. Subjects and Methods: Structured questionnaire was used to elicit feedback from participants. The responses were coded on 5-point Likert scale. Modifications in seminar sessions such as role plays, quiz, tests, group discussion, and patient-oriented problem-solving exercises were introduced along with SLS. Statistical Analysis Used: The data were analyzed using SPSS version 16. The descriptive data were expressed using frequencies and percentages. Wilcoxon signed rank test, and Friedman tests were used to compare traditional with modified seminars. Results: The participants identified interaction as the most important component of a seminar. Majority opined that the teacher should summarize at the end of SLS. Student feedback shows that modified seminars created more interest, enthusiasm, and inspiration to learn the topic when compared to traditional SLS. They also increased peer coordination and group dynamics. Students opined that communication skills and teacher-student interactions were not improved with modified seminars. Conclusions: Interventions in the form of modified SLS may be adopted to break the monotony of traditional seminars through active participation, peer interaction, and teamwork. PMID:27563587

  15. Recorded interactive seminars and follow-up discussions as an effective method for distance learning.

    Science.gov (United States)

    Miller, Kenneth T; Hannum, Wallace M; Proffit, William R

    2011-03-01

    Previous studies have suggested that, although orthodontic residents prefer to be live and interactive in a seminar, they learn almost as much when watching a previously recorded interactive seminar and following up with live discussion. Our objective was to test the effectiveness and acceptability of using previously recorded interactive seminars and different types of live follow-up discussions. Residents at schools participating from a distance completed preseminar readings and at their convenience watched streaming video of some or all recordings of 4 interactive seminar sequences consisting of 6 seminars each. Afterward, distant residents participated in 1 of 4 types of interaction: local follow-up discussion, videoconference, teleconference, and no discussion. The effectiveness of the seminar sequences was tested by pretest and posttest scores. Acceptability was evaluated from ratings of aspects of the seminar and discussion experience. Open-ended questions allowed residents to express what they liked and to suggest changes in their experiences. In each seminar sequence, test scores of schools participating through recordings and follow-up discussions improved more than those participating live and interactive. After viewing, residents preferred local follow-up discussion, which was not statistically different from participating live and interactive both locally and from a distance. Videoconference and teleconference discussions were both more acceptable to residents than no follow-up discussion, which was found to be significantly below all methods tested. When residents are live and interactive in a seminar, there does not appear to be a significant difference between being local vs at a distance. Recorded interactive seminars with follow-up discussions are also an effective and acceptable method of distance learning. Residents preferred local follow-up discussion, but, at a distance, they preferred videoconference to both teleconference and no discussion

  16. Management & Communication - Programme of Seminars September to December 2003

    CERN Multimedia

    Nathalie Dumeaux

    2003-01-01

    Situation : 23.09.2003 Dates Days Available Séminaires bilingues/Bilingual seminars Managing a CERN unit - to be a Manager/ Gérer une unité au CERN - Etre Manager (Module 1) 7, 8, 9, 10 octobre 3 non Communication interpersonnelle/ Interpersonal Communication (Module 1-CM) 21, 22, 23 octobre 3 non Managing a CERN unit - to be a Manager/ Gérer une unité au CERN - Etre Manager (Module 2) 28, 29 octobre 2 non Gestion de la qualité/Quality Management 10, 11, 12 novembre 3 oui Managing a CERN unit - to be a Manager/ Gérer une unité au CERN - Etre Manager (Module 3) 11, 12 novembre 2 non Gestion des risques /Risk Management 11, 12 décembre 2 oui Seminars In English Communicating Effectively (first part) 12, 13 November 4 yes Communicating Effectively (second part) 11, 12 December Communicating effectively in your team 19, 20 November 2 no Performance Appraisal Training MAPS 26, 27, 28 November 3 yes Managing by Project 3, 4 December 3 n...

  17. 5th Seminar on Stochastic Processes, Random Fields and Applications

    CERN Document Server

    Russo, Francesco; Dozzi, Marco

    2008-01-01

    This volume contains twenty-eight refereed research or review papers presented at the 5th Seminar on Stochastic Processes, Random Fields and Applications, which took place at the Centro Stefano Franscini (Monte Verità) in Ascona, Switzerland, from May 30 to June 3, 2005. The seminar focused mainly on stochastic partial differential equations, random dynamical systems, infinite-dimensional analysis, approximation problems, and financial engineering. The book will be a valuable resource for researchers in stochastic analysis and professionals interested in stochastic methods in finance. Contributors: Y. Asai, J.-P. Aubin, C. Becker, M. Benaïm, H. Bessaih, S. Biagini, S. Bonaccorsi, N. Bouleau, N. Champagnat, G. Da Prato, R. Ferrière, F. Flandoli, P. Guasoni, V.B. Hallulli, D. Khoshnevisan, T. Komorowski, R. Léandre, P. Lescot, H. Lisei, J.A. López-Mimbela, V. Mandrekar, S. Méléard, A. Millet, H. Nagai, A.D. Neate, V. Orlovius, M. Pratelli, N. Privault, O. Raimond, M. Röckner, B. Rüdiger, W.J. Runggaldi...

  18. Proceedings of the First APEC Coal Flow Seminar

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-10-04

    This proceedings includes papers presented at the First APEC Coal Flow Seminar held at Tokyo in October, 1994. In this seminar, two keynote speeches were presented, and three panel discussions were held. `Role of coal in energy supply and demand` and `Coal: the only long term option` were presented as keynote speeches. `Role of coal in energy supply and demand,` `Forecast for coal demand,` and `Forecast for coal supply` were discussed in the panel discussions. The objective of the Panel 1 was to put into focus the role of coal in the APEC region against the backdrop of the world situation. The key issue which came out of the discussion was the difference between Europe and Asia. China was identified as the main reason for the difference. The objective of the Panel 2 was to look at the forecast for coal demand in the APEC region, with particular focus on Asia. In the Panel 3, representatives from five leading coal producing countries presented their views on coal reserves and production. 121 figs., 96 tabs.

  19. Genotoxicity testing of 3,4,5-trimethylfuran-2(5H)-one, a compound from plant-derived smoke with germination inhibitory activity.

    Science.gov (United States)

    Light, Marnie E; Anthonissen, Roel; Maes, Annemarie; Verschaeve, Luc; Pošta, Martin; Van Staden, Johannes

    2015-01-15

    Plant-derived smoke and certain smoke compounds improve seed germination and enhance seedling growth of many species. Thus, smoke-infused water and the active smoke-derived compounds have the potential to be used in different agricultural and horticultural applications. However, despite these interesting and potentially practical properties, it should also be ascertained whether such compounds may pose a health risk, particularly if they are to be used in the production of food or fodder crops. Amongst some of the aspects that would be important to understand are any possible genotoxic properties that the compounds may possess due to potential carry-over effects. Here, we report on a genotoxicity study of 3,4,5-trimethylfuran-2(5H)-one, a compound from plant-derived smoke previously shown to have germination inhibitory activity. Using two in vitro tests, namely the bacterial VITOTOX® test (with/without S9 metabolic activation) and the cytome assay on human C3A cells, no genotoxicity or toxicity was found. Furthermore, these results support a previous study where a related smoke-derived compound with germination promoting properties was investigated.

  20. Synergistic relationship between the Columbia University Appetitive Behavior Seminar and the satiating effect of cholecystokinin.

    Science.gov (United States)

    Smith, Gerard P

    2013-12-01

    Synergism between the Columbia University Appetitive Behavior Seminar and the research program of Smith and Gibbs on the satiating effect of cholecystokinin during the past 40 years is described. The Seminar was synergistic with the research program in five ways. First, the steady parade of speakers gave us a window on the varied and interesting work going on in the field. Second, the Seminar was the kind of audience for presentations of the work-in-progress on CCK that scientists hope for and rarely find. Criticism by members of the Seminar was relentless and constructive, and ideas for further experiments or new ways to tackle problematic data poured forth. Third, members of the Seminar did experiments that facilitated the experimental success of the research program. Fourth, members of the Seminar tutored us on topics that we wanted to import into the research program on CCK. Fifth, and probably most important, members of the Seminar gave us the encouragement, good humor, and friendship so necessary for coping with the struggles of the scientific life.

  1. Dietary Regulation of Keap1/Nrf2/ARE Pathway: Focus on Plant-Derived Compounds and Trace Minerals

    Directory of Open Access Journals (Sweden)

    Amanda L. Stefanson

    2014-09-01

    Full Text Available It has become increasingly evident that chronic inflammation underpins the development of many chronic diseases including cancer, cardiovascular disease and type 2 diabetes. Oxidative stress is inherently a biochemical dysregulation of the redox status of the intracellular environment, which under homeostatic conditions is a reducing environment, whereas inflammation is the biological response to oxidative stress in that the cell initiates the production of proteins, enzymes, and other compounds to restore homeostasis. At the center of the day-to-day biological response to oxidative stress is the Keap1/Nrf2/ARE pathway, which regulates the transcription of many antioxidant genes that preserve cellular homeostasis and detoxification genes that process and eliminate carcinogens and toxins before they can cause damage. The Keap1/Nrf2/ARE pathway plays a major role in health resilience and can be made more robust and responsive by certain dietary factors. Transient activation of Nrf2 by dietary electrophilic phytochemicals can upregulate antioxidant and chemopreventive enzymes in the absence of actual oxidative stress inducers. Priming the Keap1/Nrf2/ARE pathway by upregulating these enzymes prior to oxidative stress or xenobiotic encounter increases cellular fitness to respond more robustly to oxidative assaults without activating more intense inflammatory NFκB-mediated responses.

  2. Arts, health & wellbeing: reflections on a national seminar series and building a UK research network

    Science.gov (United States)

    Stickley, Theo; Parr, Hester; Atkinson, Sarah; Daykin, Norma; Clift, Stephen; De Nora, Tia; Hacking, Sue; Camic, Paul M; Joss, Tim; White, Mike; Hogan, Susan J

    2017-01-01

    Abstract An account is provided of a UK national seminar series on Arts, Health and Wellbeing funded by the Economic and Social Research Council during 2012–13. Four seminars were organised addressing current issues and challenges facing the field. Details of the programme and its outputs are available online. A central concern of the seminar programme was to provide a foundation for creating a UK national network for researchers in the field to help promote evidence-based policy and practice. With funding from Lankelly Chase Foundation, and the support of the Royal Society for Public Health, a Special interest Group for Arts, Health and Wellbeing was launched in 2015. PMID:28163778

  3. Proceedings of the 33. AMOP technical seminar on environmental contamination and response

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2009-07-01

    Environment Canada's technical seminars on its Arctic and Marine Oilspill Program (AMOP) has evolved into an international technical forum about oil spills in any environment as well as other spill-related topics. The conference addresses issues such as preventing, assessing, containing, and cleaning up spills of hazardous materials. It also deals with solutions for remediating and rehabilitating contaminated sites. The 15 sessions of the conference were entitled: (1) physical and chemical properties of oil and behaviour of oil spills, (2) shoreline response (3) chemical, biological, radiological-nuclear and explosives (CBRNE) response, (5) remediation, restoration and rehabilitation of hazardous materials spills, (6) remediation, restoration and rehabilitation of oil spills, (7) oil spill contingency planning, preparation and prevention, (8) oil spill modelling, (9) Joint Industry Program (JIP) on oil spill response for Arctic and ice-covered waters, (10) contingency planning, preparation and prevention of hazardous materials spills, (11) hazardous and noxious substances, (12) case histories and recent hazardous material spill experiences, (13) response technologies and countermeasures for oil spills, (14) case histories and recent oil spill experiences, and (15) fate and effect of oil. The conference also included a poster session with papers. The conference featured 74 presentations, of which 53 have been catalogued separately for inclusion in this database. refs., tabs., figs.

  4. Integration of Ethics across the Curriculum: From First Year through Senior Seminar.

    Science.gov (United States)

    Gasparich, Gail E; Wimmers, Larry

    2014-12-01

    The Fisher College of Science and Mathematics (FCSM) at Towson University (TU) has integrated authentic research experiences throughout the curriculum from first year STEM courses through advanced upper-level classes and independent research. Our observation is that training in both responsible conduct of research (RCR) and bioethics throughout the curriculum was an effective strategy to advance the cognitive and psychosocial development of the students. As students enter TU they generally lack the experience and tools to assess their own competence, to apply ethical debates, to investigate scientific topics from an ethical perspective, or to integrate ethics into final conclusions. Student behavior and development follow cognitive models such as described in the theories put forth by Piaget, Kohlberg, and Erikson, both for initial learning and for how concepts are understood and adopted. Three examples of this ethics training integration are described, including a cohort-based course for first year students in the STEM Residential Learning Community, a cohort-based course for community college students that are involved in an NIH-funded Bridges to the Baccalaureate program, and a senior seminar in Bioethics in the Molecular Biology, Biochemistry and Bioinformatics Program. All three focus on different aspects of RCR and bioethics training, providing opportunities for students to learn about the principles of effective decision-making, critical and analytical thinking, problem solving, and communication with increasing degrees of complexity as they move through the curriculum.

  5. Integration of Ethics across the Curriculum: From First Year through Senior Seminar

    Directory of Open Access Journals (Sweden)

    Gail E. Gasparich

    2014-10-01

    Full Text Available The Fisher College of Science and Mathematics (FCSM at Towson University (TU has integrated authentic research experiences throughout the curriculum from first year STEM courses through advanced upper-level classes and independent research. Our observation is that training in both responsible conduct in research (RCR and bioethics throughout the curriculum was an effective strategy to advance the cognitive and psychosocial development of the students. As students enter TU they generally lack the experience and tools to assess their own competence, to apply ethical debates, to investigate scientific topics from an ethical perspective, or to integrate ethics into final conclusions. Student behavior and development follow cognitive models such as described in the theories put forth by Piaget, Kohlberg, and Erikson, both for initial learning and for how concepts are understood and adopted. Three examples of this ethics training integration are described, including a cohort-based course for first year students in the STEM Residential Learning Community, a cohort-based course for community college students that are involved in an NIH-funded Bridges to the Baccalaureate program, and a senior seminar in Bioethics in the Molecular Biology, Biochemistry and Bioinformatics Program. All three focus on different aspects of RCR and bioethics training, providing opportunities for students to learn about the principles of effective decision-making, critical and analytical thinking, problem solving, and communication with increasing degrees of complexity as they move through the curriculum.

  6. China will Hold Seminar to Greet the World Standards Day

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    @@ Here comes 2004, the 35th session of the World Standards Day. The theme of this session is"Standards Connect the World", which is precisely a good turning point not only for the domestic economy to connect rails gradually with international, but also for national government to consummate and strengthen the standardization management system, to advance standardization work, and to raise the standardization level, after China's entrance into the World Trade Organization. Therefore, when the 35th session of the World Standards Day is arriving, sponsored by the SAC (Standardization Administration of China) and organized by CAS (China Association for Standardization), China will hold a seminar on October 14 in the Great Hall of the People.

  7. Proceedings of the Second APEC Coal Flow Seminar Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-12-05

    This proceedings includes papers presented at the Second APEC Coal Flow Seminar held at Shanghai in December, 1995. Three keynote speeches were presented, and two panel discussions were held. `Medium-term outlook for coal trade,` `Energy and the environment,` and `Progress with environmental control technology and technical exchanges between economies` were presented as keynote speeches. In the panel discussions, `Achieving low environmental impact from coal production and utilization` and `How to tackle environmental issues related to coal` were discussed. The Panel 1 was divided into Part 1 and Part 2. In the Part 1, overview of current environmental protection policy measures was discussed in relation to coal production and use in economies where coal consumption has been increasing significantly. In the Part 2, overview of current environmental protection policy measures was discussed in relation to coal production and use in major coal producing and consuming economies. 38 refs., 64 figs., 31 tabs.

  8. 2005 CNPC S&E International Seminar on Borehole Technology

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    @@ From 23rd to 24th in September, the 2005 CNPC S&E International Seminar on Borehole Technology was held in Beijing. Invited by CNPC S&E, 68 honorable guests from 14 countries in Central Asia, Africa, North and South Americas and Southeast Asia and more than 100 representatives for the embassies in the People's Republic of China from 13 countries discussed the trend,progress and utilization of borehole technology and the service strength of CNPC's borehole technology together.The honorable attendees can further know the technical strength of CNPC S&E through this communication,and therefore find out the best cooperation way to create a higher value for the oil company in one hand, and improve the force and popularity of CNPC S&E in the international market on the other hand.

  9. Particle Physics Seminar: Towards 3+1 Neutrino Mixing

    CERN Multimedia

    Geneva University

    2011-01-01

    GENEVA UNIVERSITY Ecole de physique Département de physique nucléaire et corspusculaire 24, quai Ernest-Ansermet 1211 Genève 4 Tél.: (022) 379 62 73 Fax: (022) 379 69 92 Wednesday  12 October  2011 PARTICLE PHYSICS SEMINAR at 17.00 hrs – Stückelberg Auditorium “Towards 3+1 Neutrino Mixing” Par Prof. Carlo Giunti, INFN Torino I will review the recent experimental indications in favor of  short-baseline neutrino oscillations. I will discuss their interpretation in the framework of neutrino mixing schemes with one or more sterile neutrinos which have masses around the eV scale. Taking into account also cosmological constraints, I will present arguments in favor of 3+1 neutrino mixing with one sterile neutrino at the eV scale. Information : http://dpnc.unige.ch/seminaire/annonce.html Organizer : G. Pasztor

  10. Proceedings of the Third APEC Coal Flow Seminar

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-11-26

    This proceedings includes papers presented at the Third APEC Coal Flow Seminar held at Terrigal, Australia in November, 1996. Keynote addresses, three sessions for discussions, and presentations by members economies are included. `Future investment requirements for coal in the APEC region,` `Barriers to investment across the APEC region coal chain,` `International commercial financier`s perspective on coal,` `The role of advanced coal technologies in greenhouse gas abatement and financing its development and uptake,` `Investment issues affecting the uptake of clean coal technology (CCT),` `Role of multilateral development banks in financing CCT to reduce greenhouse gas emissions,` and `Strategies for addressing regional coal issues` were presented as keynote addresses. In the sessions, investment issues facing coal power development, financing coal and investment, and investment strategies for CCT were discussed. 58 refs., 42 figs., 40 tabs.

  11. Accelerating Innovation... in Medicine | Seminar by Eleanor Blakely | 10 July

    CERN Multimedia

    2014-01-01

    Reflections and perspectives on 60 years of particle therapy, by Eleanor A. Blakely, Ph.D., Senior Staff Biophysicist, Ernest Orlando Lawrence Berkeley National Laboratory, is the first of a new series of seminars proposed by the Medical Applications Team.   Thursday 10 July 4.30 p.m. - 5.30 p.m. (*) CERN Main Auditorium Please register at: https://indico.cern.ch/event/326070/   Dr John H. Lawrence successfully treated the first patient with proton therapy in September 1954, the very month and year CERN was created. The treatment of certain cancers and metabolic and neurological diseases followed with protons and alpha particle beams produced in his brother Ernest's Nobel-Prize-winning accelerators. Recent successes in the treatment of specific cancers with heavier ions such as carbon are being reported in several continents. This presentation will briefly review the six decades of the entwined histories of CERN and the Lawrence Berkeley National Laboratory in dev...

  12. A Graduate Seminar on Social Problems: Community Professionals and the Urban Community as Laboratory

    Science.gov (United States)

    Manis, Jerome G.; And Others

    1974-01-01

    A melding of community professionals, graduate students, and sociology faculty to identify and study urban community problems proved to be a viable technique for an experimental seminar program. (Author/KM)

  13. Distant Echo of a Strong Voice: Reflections on Margaret Mead's Evaluation of the Salzburg Seminar.

    Science.gov (United States)

    Patton, Michael Quinn

    2003-01-01

    Comments on the evaluation by Margaret Mead of the first Salzburg Seminar (1947). Notes the strength and clarity of Mead's evaluation report, which was written without the aid of the many tools on which today's evaluators draw. (SLD)

  14. SPECIAL SEMINAR - The NOTTE experiment, or how to become a Total Solar Eclipse chaser

    CERN Document Server

    CERN. Geneva

    2007-01-01

    The seminar will be followed by a brief presentation of future camps for solar eclipse chasers and scientists organized in 2008 in Russia, Kazakhstan, China and Mongolia, in 2009 in Shanghai and on the Easter Island in 2010.

  15. Monterey Strategy Seminar: Day 2: Dissuasion in the U.S. Defense Strategy.

    OpenAIRE

    Russell, James A; Pulsipher, Lashley; Zellen, Barry; Lavoy, Peter R.; Clary, Christopher

    2004-01-01

    Monterey Strategy Seminar: Day 1: Capabilities Based Planning. Day 2: Dissuasion in the U.S. Defense Strategy. Day 3: Global Strike Warfare Naval Postgraduate School Center for Contemporary Conflict (CCC)

  16. Uudised : Duo Veski ئ Kalluste Londonis. Rahvusvaheline seminar EMAs. Heliloojate suaree / Igor Garshnek

    Index Scriptorium Estoniae

    Garšnek, Igor, 1958-

    2000-01-01

    Duo Veski ئ Kalluste annab 5. nov. kontserdi Londoni kuninglikus muusikakolledzhis VI Briti saksofonikongressi raames. 23. ja 24. okt. toimus EMAs "Tempuse" programmi raames seminar "Public relations and Fundraising". 30. okt. toimunud Heliloojate Liidu töökoosolekust

  17. The Swedish electric and hybrid vehicle R, D and D program. Seminar October 1998

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-12-01

    This publication presents a selection of the ongoing projects in the form of abstracts, within the KFB RDD-program Electric- and Hybrid Vehicles. These projects were presented at a project manager seminar 20-21 October 1998

  18. Uudised : Duo Veski ئ Kalluste Londonis. Rahvusvaheline seminar EMAs. Heliloojate suaree / Igor Garshnek

    Index Scriptorium Estoniae

    Garšnek, Igor, 1958-

    2000-01-01

    Duo Veski ئ Kalluste annab 5. nov. kontserdi Londoni kuninglikus muusikakolledzhis VI Briti saksofonikongressi raames. 23. ja 24. okt. toimus EMAs "Tempuse" programmi raames seminar "Public relations and Fundraising". 30. okt. toimunud Heliloojate Liidu töökoosolekust

  19. Freshman seminars. Do they help pre-nursing students adjust to college life?

    Science.gov (United States)

    Raingruber, Bonnie

    2004-01-01

    One purpose of this phenomenological study was to identify challenges pre-nursing students face as they enter college. A second purpose was to evaluate the effectiveness of a Freshman seminar in helping students develop a sense of belonging on campus. An interpretive analysis was completed of 20 student essays focused on these challenges and the effectiveness of the Freshman seminar. Students reported that three major challenges confronted them as they transitioned from high school to college. These challenges were to "make the space on campus my own," "get used to the way things are done in college," and "get a sense of who I really am." The Freshman seminar helped pre-nursing students settle into a new environment and better prepare themselves for nursing school. Strategies used in the freshman seminar are also applicable to service delivery settings.

  20. 07071 Report on Dagstuhl Seminar -- Web Information Retrieval and Linear Algebra Algorithms

    OpenAIRE

    Frommer, Andreas; Mahoney, Michael W.; Szyld, Daniel B.

    2007-01-01

    A seminar concentrating on the intersection of the fields of information retrieval and other web-related aspects with numerical and applied linear algebra techniques was held with the attendance of scientists from industry and academia.

  1. Expansion of the Role of Population Education Called for at the Regional Consultative Seminar.

    Science.gov (United States)

    Population Education Newsletter and Forum, 1986

    1986-01-01

    Provides an overview of the deliberations, issues, and recommendations that occurred during a seminar on population education in Bangkok in 1986. Identifies specific actions that need to be taken in educational programs in Asia and in the Pacific. (ML)

  2. The obesity and fatty liver are reduced by plant-derived Pediococcus pentosaceus LP28 in high fat diet-induced obese mice.

    Directory of Open Access Journals (Sweden)

    Xingrong Zhao

    Full Text Available We evaluated the effect of an oral administration of a plant-derived lactic acid bacterium, Pediococcus pentosaceus LP28 (LP28, on metabolic syndrome by using high fat diet-induced obese mice. The obese mice were divided into 2 groups and fed either a high fat or regular diet for 8 weeks. Each group was further divided into 3 groups, which took LP28, another plant-derived Lactobacillus plantarum SN13T (SN13T or no lactic acid bacteria (LAB. The lean control mice were fed a regular diet without inducing obesity prior to the experiment. LP28 reduced body weight gain and liver lipid contents (triglyceride and cholesterol, in mice fed a high fat diet for 8 weeks (40%, 54%, and 70% less than those of the control group without LAB, and P = 0.018, P<0.001, and P = 0.021, respectively, whereas SN13T and the heat treated LP28 at 121°C for 15 min were ineffective. Abdominal visceral fat in the high fat diet mice fed with LP28 was also lower than that without LAB by 44%, although it was not significant but borderline (P = 0.076. The sizes of the adipocytes and the lipid droplets in the livers were obviously decreased. A real-time PCR analyses showed that lipid metabolism-related genes, such as CD36 (P = 0.013, SCD1 encoding stearoyl-CoA desaturase 1 (not significant but borderline, P = 0.066, and PPARγ encoding peroxisome proliferator-activated receptor gamma (P = 0.039, were down-regulated by taking LP28 continuously, when compared with those of the control group. In conclusion, LP28 may be a useful LAB strain for the prevention and reduction of the metabolic syndrome.

  3. Determining the Origin and Fate of Particulate Plant-Derived Organic Matter in the Rhone River (France) : A Lipid Tracer Review

    Science.gov (United States)

    Galeron, M. A.; Amiraux, R.; Charriere, B.; Radakovitch, O.; Raimbault, P.; Garcia, N.; Lagadec, V.; Vaultier, F.; Rontani, J. F.

    2014-12-01

    A number of lipid tracers including fatty acids, hydroxyacids, n-alkanols, sterols and triterpenoids were used to determine the origin and fate of suspended particulate organic matter (POM) collected in the Rhone River (France), with a main focus on phytosterols, such as sitosterol, desmosterol, brassicasterol and cholesterol. This seasonal survey (April 2011 to May 2013) revealed a year-round strong terrigenous contribution to the plant derived particulate organic matter (POM) with significant algal inputs observed in March and attributed to phytoplanktonic blooms likely dominated by diatoms. Specific sitosterol and cholesterol degradation products were quantified and used to estimate the part of biotic and abiotic degradation of POM within the river. Plant-derived organic matter appears to be mainly affected by photo-oxidation and autoxidation (free radical oxidation), while organic matter of human origin, evidenced by the presence of coprostanol, is clearly more prone to bacterial degradation. Despite the involvement of an intense autoxidation inducing homolytic cleavage of peroxy bonds, a significant proportion of hydroperoxides is still intact in higher plant debris. These compounds could play a role in the degradation of terrestrial material by inducing an intense autoxidation upon its arrival at sea. Although sitosterol has been commonly used as a tracer of the terrestrial origin of POM in rivers, we show here that is it also found in phytoplankton, which highlights the need to use different tracers to determine the origin of POM in rivers. As part of the set of tracers we use, we have identified betulin to be an interesting candidate, although limited to a number of angiosperms species. Not only can we trace betulin to an unequivocal terrestrial origin, we also identified its specific degradation products, allowing us to trace the degradation state of angiosperm particulate debris in rivers, as well as the type of degradation undergone.

  4. The reactivity of plant-derived organic matter and the potential importance of priming effects along the lower Amazon River

    Science.gov (United States)

    Ward, Nicholas D.; Bianchi, Thomas S.; Sawakuchi, Henrique O.; Gagne-Maynard, William; Cunha, Alan C.; Brito, Daimio C.; Neu, Vania; Matos Valerio, Aline; Silva, Rodrigo; Krusche, Alex V.; Richey, Jeffrey E.; Keil, Richard G.

    2016-06-01

    Here we present direct measurements of the biological breakdown of 13C-labeled substrates to CO2 at seven locations along the lower Amazon River, from Óbidos to the mouth. Dark incubation experiments were performed at high and low water periods using vanillin, a lignin phenol derived from vascular plants, and at the high water period using four different 13C-labeled plant litter leachates. Leachates derived from oak wood were degraded most slowly with vanillin monomers, macrophyte leaves, macrophyte stems, and whole grass leachates being converted to CO2 1.2, 1.3, 1.7, and 2.3 times faster, respectively, at the upstream boundary, Óbidos. Relative to Óbidos, the sum degradation rate of all four leachates was 3.3 and 2.6 times faster in the algae-rich Tapajós and Xingu Rivers, respectively. Likewise, the leachates were broken down 3.2 times more quickly at Óbidos when algal biomass from the Tapajós River was simultaneously added. Leachate reactivity similarly increased from Óbidos to the mouth with leachates breaking down 1.7 times more quickly at Almeirim (midway to the mouth) and 2.8 times more quickly across the river mouth. There was no discernible correlation between in situ nutrient levels and remineralization rates, suggesting that priming effects were an important factor controlling reactivity along the continuum. Further, continuous measurements of CO2, O2, and conductivity along the confluence of the Tapajós and Amazon Rivers and the Xingu and Jarauçu Rivers revealed in situ evidence for enhanced O2 drawdown and CO2 production along the mixing zone of these confluences.

  5. 30. MPA-Seminar 'Safety and reliability in energy technology' in conjunction with the 9th German-Japanese seminar. Vol. 2 (Papers 27-53); 30. MPA-Seminar 'Sicherheit und Verfuegbarkeit in der Energietechnik' in Verbindung mit dem 9. Deutsch-Japanischen Seminar. Bd. 2 (Vortraege 27-53)

    Energy Technology Data Exchange (ETDEWEB)

    Roos, E. (comp.)

    2004-07-01

    he 30th MPA-seminar on ''Safety and Availability in Energy Engineering'' was held in conjuction with the 9th German-Japanese Seminar. The 52 contributions were published in two volumes. Volume 1 contains the contributions to the following sessions: fracture mechanics, fatigue, welding, environmental impact and European research projects. Volume 2 contains contributions of sessions 6-9: high-temperature application, modelling-simulation, ageing management and non-destructive testing. (uke)

  6. Evaluation of usefulness of seminar as a learning tool at medical undergraduate level

    Directory of Open Access Journals (Sweden)

    Diwanshu Sharma

    2016-10-01

    Conclusions: Many of the students feel that this technique of seminar programme is helpful for them in the long run. Thus teaching by way of seminar could be an effective learning method as it involves the three major domains of teaching i.e., cognitive, affective and psychomotor skills and is thus well -accepted among the medical students. [Int J Basic Clin Pharmacol 2016; 5(5.000: 2143-2145

  7. NKS/SOS-1 seminar on quality assurance; NKS/SOS-1 seminarium om kvalitetssaekring

    Energy Technology Data Exchange (ETDEWEB)

    Hammar, L. [ES-Konsult (Sweden); Wahlstroem, B. [VTT Automation (Finland)

    2001-02-01

    The backgrounds and the conduct of the seminar is described. Summaries are given of all presentations and slides shown are appended. An account is given of discussions on different quality issues which were conducted during the seminar in separate groups. Concluding remarks made by the Chairman of NKS are reproduced. Further conclusions will be presented in the main report from the project 'Views on quality assurance at Finnish and Swedish nuclear power plants and the Halden reactor'. (au)

  8. 30. MPA-Seminar 'Safety and reliability in energy technology' in conjunction with the 9th German-Japanese seminar. Vol. 1 (Papers 1-26); 30. MPA-Seminar 'Sicherheit und Verfuegbarkeit in der Energietechnik' in Verbindung mit dem 9. Deutsch-Japanischen Seminar. Bd. 1 (Vortraege 1-26)

    Energy Technology Data Exchange (ETDEWEB)

    Roos, E. (comp.)

    2004-07-01

    The 30th MPA-seminar on ''Safety and Availability in Energy Engineering'' was held in conjuction with the 9th German-Japanese Seminar. The 52 contributions were published in two volumes. Volume 1 contains the contributions to the following sessions: fracture mechanics, fatigue, welding, environmental impact and European research projects. Volume 2 contains contributions of sessions 6-9: high-temperature application, modelling-simulation, ageing management and non-destructive testing. (uke)

  9. East Africa seminar and workshop of remote sensing of natural resources and environment

    Science.gov (United States)

    Deutsch, Morris

    1975-01-01

    Report on total program covering East Africa Seminar and Workshop on remote sensing of natural resources and the environment held in Nairobi, Kenya, March 21 April 3, 1974, attended by participants from 10 English-speaking African nations. Appendices are included for Seminar proceedings, workshop lectures and outlines, field trip reports and critiques by participants, and reports on potential applications of an operational earth resources satellite for the participating countries.

  10. Toxicological Evaluation of Realistic Emissions of Source Aerosols (TERESA): Application to Power Plant-Derived PM2.5

    Energy Technology Data Exchange (ETDEWEB)

    Annette Rohr

    2007-02-28

    This report documents progress made on the subject project during the period of September 1, 2007 through February 28, 2007. The TERESA Study is designed to investigate the role played by specific emissions sources and components in the induction of adverse health effects by examining the relative toxicity of coal combustion and mobile source (gasoline and/or diesel engine) emissions and their oxidative products. The study involves on-site sampling, dilution, and aging of coal combustion emissions at three coal-fired power plants, as well as mobile source emissions, followed by animal exposures incorporating a number of toxicological endpoints. The DOE-EPRI Cooperative Agreement (henceforth referred to as ''the Agreement'') for which this technical progress report has been prepared covers the performance and analysis of field experiments at the first TERESA plant, located in the Upper Midwest and henceforth referred to as Plant 0, and at two additional coal-fired power plants (Plants 1 and 2) utilizing different coal types and with different plant configurations. During this reporting period, fieldwork was completed at Plant 2, located in the Midwest. The following scenarios were completed: (1) July 19-22: POS (oxidized + SOA); (2) July 25-28: PONS (oxidized + neutralized + SOA); (3) August 8-13: P (primary); (4) August 14-15: POS; (5) August 16-17: POS (MI rats); (6) August 28-31: OS (oxidized + SOA, without primary particles); (7) September 1-4: O (oxidized, no primary particles); (8) September 6-9: S (SOA, no primary particles); and (9) September 19-22: PO (oxidized). Results indicated some biological effects with some scenarios. Also during this reporting period, the annual meeting of the TERESA Technical Advisory Committee was held at the Harvard School of Public Health in Boston. During the next reporting period, data analyses will continue for Plant 2 as well as for pooled data from all three plants. Manuscripts documenting the overall

  11. Proceedings of the summary seminar within the NKS-B programme 2002-2005[Radioecology

    Energy Technology Data Exchange (ETDEWEB)

    Ilus, E. (ed.) [Radiation and Nuclear Safety Authority, STUK (Finland)

    2006-04-15

    This report contains the proceedings of the NKS-B Summary Seminar held on 24-25 October 2005 in Tartu, Estonia. The aim of the seminar was to provide a forum for presenting and discussing the results obtained in the NKS-B programme during the project period 2002 - 2005. The main attention was focused on radioecology and measurement techniques including presentations on the work done in the Projects INDOFERN (New Indicator Organisms for Environmental Radioactivity), LABINCO (Intercomparison of Laboratory Analyses of Radionuclides in Environmental Samples) and ECODOSES (Improving Radiological Assessments of Doses to Humans from Terrestrial Ecosystems). The total number of presentations in the seminar was 27. The seminar was also the final seminar of the four-year INDOFERN Project. The objective of the project was to identify new indicator organisms and biomarkers for assessment of environmental radioactivity in normal and emergency situations. The goal was to search new useful organisms accumulating effectively and specifically certain radionuclides in various Nordic ecosystems (forest, fresh water, marine), and to compare their indicator value to those of the earlier known indicators. The project yielded new data on the occurrence and transport of radionuclides in a wide scale of Nordic ecosystems. A summary of the whole project, and summaries of the work done in all the participating laboratories were presented in 13 presentations in the seminar.

  12. FOREWORD: International Scientific Seminars on "Fundamental and Applied Problems of Photonics and Condensed Matter Physics"

    Science.gov (United States)

    Yurchenko, Stanislav; Ryzhii, Viktor

    2015-01-01

    International Scientific Seminars ''Fundamental and Applied Problems of Photonics and Condensed Matter Physics'' were held in Bauman Moscow State Technical University (BMSTU) in May - June 2014. The idea of the Seminars was to organize a series of meetings between young scientists and discuss actual problems and the latest results in Photonics and Condensed Matter Physics. There were eight Sessions: Modern Problems of Condensed Matter Physics; Laser Physics; Spectroscopy of Condensed Matter; Terahertz Optical Technology; Optical Signals Processing; Physics of Optical Strong Correlated Systems; Complex Dusty Plasma Physics; Biomediacal Applications of Photonics. Seminars were organized by the young group of scientists and students from Research and Educational Center ''Photonics and Infrared Technology'' at BMSTU. It brought a significant contribution to the development of youth science in the field of Physics and Photonics in Russia. More than 100 young scientists and students participated in the Seminars in spring - summer 2014. The International Scientific Seminars were supported by the Russian Foundation for Basic Research (grant # 14-08-06030-g). This volume contains proceedings of the International Scientific Seminars ''Fundamental and Applied Problems of Photonics and Condensed Matter Physics''. Stanislav Yurchenko and Viktor Ryzhii Bauman Moscow State Technical University

  13. TOXICOLOGICAL EVALUATION OF REALISTIC EMISSIONS OF SOURCE AEROSOLS (TERESA): APPLICATION TO POWER PLANT-DERIVED PM2.5

    Energy Technology Data Exchange (ETDEWEB)

    Annette C. Rohr; Petros Koutrakis; John Godleski

    2011-03-31

    (BAL) fluid cytology and biochemistry; (3) blood cytology; (4) in vivo oxidative stress in heart and lung tissue; and (5) heart and lung histopathology. In addition, at one plant, cardiac arrhythmias and heart rate variability (HRV) were evaluated in a rat model of myocardial infarction. Statistical analyses included analyses of variance (ANOVA) to determine differences between exposed and control animals in response to different scenario/plant combinations; univariate analyses to link individual scenario components to responses; and multivariate analyses (Random Forest analyses) to evaluate component effects in a multipollutant setting. Results from the power plant studies indicated some biological responses to some plant/scenario combinations. A number of significant breathing pattern changes were observed; however, significant clinical changes such as specific irritant effects were not readily apparent, and effects tended to be isolated changes in certain respiratory parameters. Some individual exposure scenario components appeared to be more strongly and consistently related to respiratory parameter changes; however, the specific scenario investigated remained a better predictor of response than individual components of that scenario. Bronchoalveolar lavage indicated some changes in cellularity of BAL fluid in response to the POS and PONS scenarios; these responses were considered toxicologically mild in magnitude. No changes in blood cytology were observed at any plant or scenario. Lung oxidative stress was increased with the POS scenario at one plant, and cardiac oxidative stress was increased with the PONS scenario also at one plant, suggesting limited oxidative stress in response to power plant emissions with added atmospheric constituents. There were some mild histological findings in lung tissue in response to the P and PONS scenarios. Finally, the MI model experiments indicated that premature ventricular beat frequency was increased at the plant studied

  14. TOXICOLOGICAL EVALUATION OF REALISTIC EMISSIONS OF SOURCE AEROSOLS (TERESA): APPLICATION TO POWER PLANT-DERIVED PM2.5

    Energy Technology Data Exchange (ETDEWEB)

    Annette C. Rohr; Petros Koutrakis; John Godleski

    2011-03-31

    (BAL) fluid cytology and biochemistry; (3) blood cytology; (4) in vivo oxidative stress in heart and lung tissue; and (5) heart and lung histopathology. In addition, at one plant, cardiac arrhythmias and heart rate variability (HRV) were evaluated in a rat model of myocardial infarction. Statistical analyses included analyses of variance (ANOVA) to determine differences between exposed and control animals in response to different scenario/plant combinations; univariate analyses to link individual scenario components to responses; and multivariate analyses (Random Forest analyses) to evaluate component effects in a multipollutant setting. Results from the power plant studies indicated some biological responses to some plant/scenario combinations. A number of significant breathing pattern changes were observed; however, significant clinical changes such as specific irritant effects were not readily apparent, and effects tended to be isolated changes in certain respiratory parameters. Some individual exposure scenario components appeared to be more strongly and consistently related to respiratory parameter changes; however, the specific scenario investigated remained a better predictor of response than individual components of that scenario. Bronchoalveolar lavage indicated some changes in cellularity of BAL fluid in response to the POS and PONS scenarios; these responses were considered toxicologically mild in magnitude. No changes in blood cytology were observed at any plant or scenario. Lung oxidative stress was increased with the POS scenario at one plant, and cardiac oxidative stress was increased with the PONS scenario also at one plant, suggesting limited oxidative stress in response to power plant emissions with added atmospheric constituents. There were some mild histological findings in lung tissue in response to the P and PONS scenarios. Finally, the MI model experiments indicated that premature ventricular beat frequency was increased at the plant studied

  15. TOXICOLOGICAL EVALUATION OF REALISTIC EMISSIONS OF SOURCE AEROSOLS (TERESA): APPLICATION TO POWER PLANT-DERIVED PM2.5

    Energy Technology Data Exchange (ETDEWEB)

    Annette Rohr

    2005-09-30

    implanted telemeters and blood chemistry (complete blood count, circulating cytokines (interleukins-1 and -6), C-reactive protein (CRP), tumor necrosis factor alpha (TNF-{alpha}), and endothelin-1). Only a subset of exposure data was available at the time of preparation of this report. Continuous PM{sub 2.5} mass (TEOM) results indicate a mass concentration of 14 {micro}g/m{sup 3} for the primary particle scenario, and a range of 151 to 385 {micro}g/m{sup 3} for the oxidized emissions scenarios. Toxicological results obtained to date from Plant 1 indicate subtle biological responses to some of the exposure scenarios. We observed statistically significant changes in several breathing pattern parameters, including tidal volume and frequency. For one scenario (oxidized emissions + SOA), we observed a significant increase in Enhanced Pause (Penh), a parameter that may reflect airflow restriction. However, the respiratory changes are very subtle and do not present a clear picture of a particular respiratory effect (e.g., airway restriction, sensory irritation, or pulmonary irritation). A significant increase in lung chemiluminescence (a marker of oxidative stress in lung tissue) in exposed animals (vs. air-exposed controls) was observed in animals exposed to oxidized emissions + SOA. No changes were observed in heart tissue, nor in any other scenario. Stage II assessments were conducted to the secondary + SOA scenario; ECG and blood analysis data are pending. Planning was initiated for Plant 2, located in the Midwest. Because of the requirement for both the FGD and the SCR to be concurrently operational for appropriate reaction conditions, fieldwork at Plant 2 is scheduled for Summer 2006. During the next reporting period, we will complete all remaining exposure and toxicological analyses for Plant 1, and the next semiannual report will include a detailed description of these data and their interpretation. We are also in the process of preparing a topical report for Plant 0.

  16. TOXICOLOGICAL EVALUATION OF REALISTIC EMISSIONS OF SOURCE AEROSOLS (TERESA): APPLICATION TO POWER PLANT-DERIVED PM2.5

    Energy Technology Data Exchange (ETDEWEB)

    Annette Rohr

    2004-12-02

    tended to be slightly higher. Exposure concentrations were about 249 {micro}g/m{sup 3} PM, of which 87 {micro}g/m{sup 3} was sulfate and approximately 110 {micro}g/m{sup 3} was secondary organic material ({approx}44%). Results indicated subtle differences in breathing pattern between exposed and control (sham) animals, but no differences in other endpoints (in vivo chemiluminescence, blood cytology, bronchoalveolar lavage fluid analysis). It was suspected that primary particle losses may have been occurring in the venturi aspirator/orifice sampler; therefore, the stack sampling system was redesigned. The modified system resulted in no substantial increase in particle concentration in the emissions, leading us to conclude that the electrostatic precipitator at the power plant has high efficiency, and that the sampled emissions are representative of those exiting the stack into the atmosphere. This is important, since the objective of the Project is to carry out exposures to realistic coal combustion-derived secondary PM arising from power plants. During the next reporting period, we will document and describe the remainder of the fieldwork at Plant 0, which we expect to be complete by mid-November 2004. This report will include detailed Phase I toxicological findings for all scenarios run, and Phase II toxicological findings for one selected scenario. Depending upon the outcome of the ongoing fieldwork at Plant 0 (i.e. the biological effects observed), not all the proposed scenarios may be evaluated. The next report is also expected to include preliminary field data for Plant 1, located in the Southeast.

  17. TOXICOLOGICAL EVALUATION OF REALISTIC EMISSIONS OF SOURCE AEROSOLS (TERESA): APPLICATION TO POWER PLANT-DERIVED PM2.5

    Energy Technology Data Exchange (ETDEWEB)

    Annette Rohr

    2006-03-31

    emissions + SOA scenarios (POS). There was a fair amount of day-to-day variation in mass concentration, even within a given exposure round; this is likely due to the inherent variation in the power plant operation. Concentrations of ozone, NO{sub x} and SO{sub 2}, and carbonyls were below 50 ppb. Total sulfate concentration ranged from 82 to 175 {micro}g/m{sup 3}. Elemental data suggest substantial day-to-day variations which again provide insight about the inherent variations attributed to plant operation. All elements were present at low concentrations except for sulfur. Other prominent elements were: Si, Br, Ca, K, La and Cu. SOA was speciated using GC-MS, with typical {alpha}-pinene oxidation products being observed. Toxicological results obtained to date from Plant 1 indicate some biological responses to some exposure scenarios. We observed pulmonary function changes, increased oxidative stress, and increases in cardiac arrhythmias in response to certain scenarios. For the oxidative stress endpoint, an increase in chemiluminescence occurred only in those scenarios including SOA. More detailed statistical modeling also points to the importance of organic material in these scenarios; additional analyses are currently underway to better understand this finding. Fieldwork for Plant 2, located in the Midwest, is scheduled for June-September 2006, and logistical planning is now underway. During the next reporting period, we will complete fieldwork at Plant 2. A draft topical report for Plant 0 was submitted to DOE-NETL in December 2005, with the final report to be submitted in April, 2006. We will also complete a topical report for Plant 1 by June 30, 2006.

  18. 2nd Nordic NJF Seminar on Reindeer Husbandry Research "Reindeer herding and land use management - Nordic perspectives"

    Directory of Open Access Journals (Sweden)

    Päivi Soppela

    2015-06-01

    Full Text Available The 2nd NJF Seminar on Reindeer Husbandry Research was held at the Arctic Centre, University of Lapland, Rovaniemi, Finland from 19 to 21 October 2014. The seminar was organised under the framework of Reindeer Husbandry Research Section of NJF (Nordic Association of Agricultural Scientists, established in 2012. Over 100 Nordic and international delegates including researchers, managers, educators, students and reindeer herders participated in the seminar.

  19. Transforming growth factor-β signaling and cancer: the 28th Sapporo Cancer Seminar, 25-27 June 2008.

    Science.gov (United States)

    Miyazono, Kohei

    2009-02-01

    The Sapporo Cancer Seminars have been held annually since 1981. The 28th Sapporo Cancer Seminar was held on 26-27 June 2008 at the Hokkaido University Conference Hall, focusing on transforming growth factor (TGF)-β signaling and cancer. More than 150 scientists participated in the seminar, and it provided a great deal of information on the role of TGF-β signaling in carcinogenesis and tumor metastasis. The possible use of TGF-β antagonists for treatment of cancers was also discussed at the seminar.

  20. FOREWORD: CCM Second International Seminar: Pressure Metrology from 1 kPa to 1 GPa

    Science.gov (United States)

    Molinar, G. F.

    1994-01-01

    The Comité Consultatif pour la Masse et les Grandeurs Apparentées (CCM), through its High Pressure and Medium Pressure Working Groups, organized this Second International Seminar on Pressure Metrology from 1 kPa to 1 GPa, which was held at the Laboratoire National d'Essais (LNE), Paris, France, from 2 to 4 June 1993. The scope of the seminar was to review the state of the art of pressure measurements in the 1 kPa to I GPa pressure range and to present innovative contributions by standards laboratories, universities and industry. The seminar was organized in six sessions: liquid-column manometers; piston gauge pressure standards; properties of liquids and gases relevant to pressure metrology; pressure transducers and transfer standards; pressure standard comparison (methods and results); dynamic pressure measurements. Each session opened with the presentation of a review paper on major requirements in that field and, at the end of the seminar, a general discussion was organized on the actual limits of accuracy of static and dynamic pressure measurements in fluid media, and the fundamental problems in pressure metrology between 1 kPa and 1 GPa. The seminar was attended by sixty scientists from twenty-four countries, all working in the field of pressure measurements. Forty-nine papers were presented. The participation of scientists from so many countries indicates the importance of pressure metrology from the scientific and industrial points of view. Most papers were presented by scientists from national standards laboratories, with eight papers from universities and four from industry. Eleven papers reported the results of cooperative work involving metrological institutions dealing with high pressure, generally national standards laboratories, an indication that scientific links are already well established at this level. Links are also strengthening between industry and standards laboratories. Although industrial participation at the seminar was relatively small

  1. YoungRad-seminar. Proceedings. Seminar for young scientists in the fields of radiophysics, radiochemistry, radioecology, radiation protection and related fields

    Energy Technology Data Exchange (ETDEWEB)

    Straelberg, E.; Sidhu, R. [Institute for Energy Technology (Norway); Petersen, R. [Technological Univ. of Denmark (Denmark); Salminen, S. [Univ. of Helsinki (Finland)

    2007-09-15

    To provide an inspiring working environment for young students and scientists, it is important that they at an early stage can take part in a network of scientists working in their fields of interest. However, within each of the five Nordic countries the network of people involved in the fields of radiophysics, radiochemistry, radioecology, radiation protection and other related fields is rather small. Educational networking is a key factor in keeping young researchers motivated to continue working within these fields, and to recruit new students. For that reason the first YoungRad-seminar was held in Helsinki 14-15 December 2006. 43 young participants including MSc and PhD students at universities, researchers at different institutes and personnel from Nordic authorities took part in the seminar. All Nordic countries except Iceland were represented. The seminar was divided into four sessions including oral and poster presentations. In addition two senior researchers were invited to speak about Nordic radioecology and NKS. This report contains the abstracts and presentations made at the seminar. (au)

  2. Changes & Challenges: Hot Topics in a New Era of Schools. Proceedings of the Education Law Association Winter Seminar (Park City, UT, March 15-18, 2001). Seminar Outlines.

    Science.gov (United States)

    Education Law Association, Dayton, OH.

    The following are outlines presented by individuals at the Education Law Association 2001 winter seminar: "Academic Freedom and the Religiously Affiliated University" (the freedom to teach, research, and publish has never been--and still is not--without limits); "How Random and Suspicionless May School Searches Be" (random and suspicionless drug…

  3. Advancing Successful Physics Majors - The Physics First Year Seminar Experience

    Science.gov (United States)

    Deibel, Jason; Petkie, Douglas

    In 2012, the Wright State University physics curriculum introduced a new year-long seminar course required for all new physics majors. The goal of this course is to improve student retention and success via building a community of physics majors and provide them with the skills, mindset, and advising necessary to successfully complete a degree and transition to the next part of their careers. This new course sequence assembles a new cohort of majors annually. To prepare each cohort, students engage in a variety of activities that span from student success skills to more specific physics content while building an entrepreneurial mindset. Students participate in activities including study skills, career night, course planning, campus services, and a department social function. More importantly, students gain exposure to programming, literature searches, data analysis, technical writing, elevator pitches, and experimental design via hands-on projects. This includes the students proposing, designing, and conducting their own experiments. Preliminary evidence indicates increased retention, student success, and an enhanced sense of community among physics undergraduate students, The overall number of majors and students eventually completing their physics degrees has nearly tripled. Associate Professor, Department of Physics.

  4. The Higgs seminar, by those who were there

    CERN Multimedia

    2012-01-01

    If the Higgs boson was treated like a rock star by the international media, take a moment to imagine the ambiance that reigned at CERN - home to the beast... When Rolf Heuer, CERN Director-General, appeared in the first-floor corridor of the Main Building, at 7.15 a.m. on Wednesday 4 July, he was met with applause from a horde of Cernois. In that moment, there was no doubt: the day would be exceptional. And it was. For us at CERN more than any other. The proof? Hear it straight from the horse's mouth...   "One might have thought that being far from the Main Auditorium last Wednesday the atmosphere would be less electrified but actually this was not true: when the seminar started, sacred silence was kept, interrupted only by warm and loud applauses, big smiles, cheerful whistling, hand shaking… one could say there was really ‘something’ in the air. A mixture of scientific enthusiasm, joy, curiosity and big amounts of rocking excitement… F...

  5. Technical Training Seminar: Physicists in the world of finance

    CERN Multimedia

    Davide Vitè

    2006-01-01

    Monday 27 February TECHNICAL TRAINING SEMINAR from 14:00 to 16:00, Council Chamber (bldg. 503) Physicists in the world of finance Oliver Cooke, Zhengyun Hu / LEHMAN BROTHERS (UK) Two PhD physicists will talk about their experiences of working in investment banking, describing what investment banks do and the jobs which attract physicists and engineers. They will introduce the derivatives markets, and explain the need for advanced modelling. In particular, they will present the many modelling techniques used, including Monte Carlo simulation, solving PDEs, stochastic calculus and data analysis. They will describe a typical day for a physicist in the world of finance, and present a case study in which they will show how they used an idea from physics to solve a finance problem. After a PhD and CERN fellowship on OPAL in the 1990s, Oliver Cooke moved to finance. He was initially a mathematical modeller of derivatives, and now is an exotic derivatives trader at Lehman Brothers in London. He will be j...

  6. Proceedings of the international seminar on atomic processes in plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Kato, Takako; Murakami, Izumi [eds.

    2000-01-01

    The International Seminar on Atomic Processes in Plasmas (ISAPP), a satellite meeting to the ICPEAC was held July 28-29 at the National Institute for Fusion Science in Toki, Gifu, Japan. About 110 scientists attended the ISAPP meeting and discussed atomic processes and atomic data required for fusion research. This Proceedings book includes the papers of the talks, posters and panel discussion given at the meeting. The invited talks described the super configuration array method for complex spectra, near-LTE atomic kinetics, R-matrix calculations, the binary-encounter dipole model for electron-impact ionization of molecules, other calculations of molecular processes, the ADAS project and the NIFS atomic data-base, and a survey of the role of molecular processes in divertor plasmas. On the experimental side crossed-beam ion-ion collision-experiments for charge transfer, and storage-ring and EBIT measurements of ionization, excitation and dielectronic recombination cross-sections were presented, and atomic processes important for x-ray laser experiments and x-ray spectroscopy of astrophysical plasmas were described. The new method of plasma polarization spectroscopy was outlined. There was also a spectroscopic study of particle transport in JT-60U, new results for detached plasmas, and a sketch of the first hot plasma experiments with the Large Helical Device recently completed at NIFS. The 63 of the presented papers are indexed individually. (J.P.N.)

  7. Proceedings of the Rome seminar on environmental geochemistry

    Energy Technology Data Exchange (ETDEWEB)

    Marini, L.; Ottonello, G. [eds.

    1998-12-31

    The paper collected in this book represent most part of the lectures given by invited speakers at the Seminar on Environmental Geochemistry, held in Rome (May 22-26, 1996) under the sponsorship of the `Dipartimento della Protezione Civile` (Ministry of the Interiors), the `Consiglio Nazionale delle Ricerche` (Strategic Projects `Geologia delle grandi aree urbane` e `Carta Geochimica d`Italia`); the University of Genoa and the `Gruppo informale di geochimica`. In deciding to assemble the Proceedings, there was the difficulty of molding the various expertise necessary to deal with the geochemical aspects of environmental problems and of presenting them in a logical sequence. In fact, Geochemistry is a vast subject, strictly connected with Physical Chemistry and Mathematics in its theoretical aspects, but also with Hydrology, Urban Geology, Chemical Engineering, and even Administration in its applicative aspects. It was then decided to privilege at first the theoretical aspects of water-rock interactions processes relevant to environmental control. Indeed, most part of the book is covered by three articles dealing with the numerical aspects of reactive flow and transport in natural systems, the role of metal-organic complexing and of surface-controlled reaction kinetics.

  8. Riddle of light: a seminar course for scientists and humanists

    Science.gov (United States)

    Stoicheff, Boris P.

    2000-06-01

    Recently a new program of `First Year Seminar Courses' was initiated in the Faculty of Arts and Science at the University of Toronto to introduce in-coming undergraduates to the excitement of university scholarship. These are full- year elective courses, and in each course students work closely with a faculty member in groups of no more than 20 students. I shall review my experiences in these past three years in organizing a course on light, optics, and photonics. The primary aim was to use the rich story of light to bring together students of a variety of intellectual interests, in the hope of demonstrating the valuable knowledge that the cultures of the humanists and scientists can bring to an understanding of the modern world. As we are all aware, the story of light is so all- embracing that this course included not only the science of light and optics, with lasers and photonics, but light in the open air, astronomy, religion, literature, art, architecture, film, stage, health and medicine, with several of the topics discussed by guest speakers. After a brief review of the story of light from its earliest beginnings, an outline of the course will be given along with the many contributions by the students and evaluation of their efforts.

  9. Proceedings of the joint Russian-American hydrogeology seminar

    Energy Technology Data Exchange (ETDEWEB)

    Tsang, C.F. [ed.] [Lawrence Berkeley National Lab., CA (United States); Mironenko, V. [ed.] [Russian Academy of Sciences, St. Petersburg (Russian Federation). Inst. of Environmental Geology; Pozdniakov, S. [ed.] [Moscow State Univ. (Russian Federation)

    1997-12-31

    Hydrogeology research has been very active in both Russia and the US because of the concerns for migration of radioactive and chemical contaminants in soils and geologic formations, as well as for water problems related to mining and other industrial operations. Russian hydrogeologists have developed various analysis and field testing techniques, sometimes in parallel with US counterparts. These Proceedings come out of a Seminar held to bring together a small group (about 15) of active Russian researchers in geologic flow and transport associated with the disposal of radioactive and chemical wastes either on the soils or through deep injection wells, with a corresponding group (about 25) of American hydrogeologists. The meeting was intentionally kept small to enable informal, detailed and in-depth discussions on hydrogeological issues of common interest. Out of this interaction, the authors hope that, firstly, they will have learned from each other and secondly, that research collaborations will be established where there is the opportunity. This proceedings presents the summaries and viewgraphs from the presentations. What cannot be conveyed here is the warm and cooperative atmosphere of these interactions, both inside and outside the formal sessions, which may well lead to future collaborations.

  10. A seminar on gardens for the health of the skin.

    Science.gov (United States)

    Ryan, Terence J; Matts, Paul J; Snyder, Brad; Orr, Vanya

    2014-05-01

    This is a report on a seminar held on January 12, 2013, at the Regional Dermatology Training Centre in Tanzania, sponsored by the International Society of Dermatology as part of its Taskforce Program for Skin Care for All: Community Dermatology. There were four themes: (i) Gardens attached to health centers increase their attractiveness and result in increased attendance and, thus, increase the utilization of effective skin care interventions. Literature on the positive effect of greenery surrounding health centers on health and the environment is reviewed. (ii) Adding an expert on agriculture to the staff of health centers in Rwanda has provided nutrition and safe medicines. (iii) In southern India, these interventions are channeled through the empowerment of tribal women in an area noted for anxiety due to unemployment in the tea and forestry industry. The gardens are used for teaching about nutrition and herbal medicines, and the women are further attracted by childcare facilities. (iv) Measuring barrier function defects gives early warning of malnutrition of the skin after damage by trauma or by ultraviolet radiation. Higher cost research techniques may help to provide the science required to produce its evidence base. In conclusion, Gardens for health should be adopted as policy by skin care providers.

  11. Neurospin Seminar: From the Proton to the Human Brain

    CERN Document Server

    CERN. Geneva

    2016-01-01

    From the Proton to the Human Brain Speaker: Prof Denis Le Bihan Abstract: The understanding of the human brain is one of the main scientific challenges of the 21st century. In the early 2000s the French Atomic Energy Commission (CEA) launched a program to conceive and build a “human brain explorer”, the first human MRI scanner operating at 11.7T. This scanner was envisioned to be part of the ambitious Iseult project, bridging together industrial and academic partners to push the limits of molecular neuroimaging, from mouse to man, using Ultra-High Field (UHF) MRI. In this seminar a summary of the main features of this magnet, and the neuroscience and medical targets of NeuroSpin where this outstanding instrument will be installed in 2017 will be surveyed. The unprecedented resolution and the new contrasts allowed by such UHF magnets, in combination with innovative concepts in physics and neurobiology, will allow to explore the human brain at a mesoscale at which everything remains to d...

  12. RJH seminar; Seminaire RJH du 7 mars 2003

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-07-01

    This document gathers the slides that have been presented at the Jules Horowitz reactor (RJH) seminar. RJH is the next experimental reactor to be built in France, it will be commissioned in 2013. Its main characteristics are: - power: 100 MW - coolant and moderator: water (input water temperature 25 C, exit water temperature 41 C), down to up flow inside the core - reflector: water and beryllium - maximal enrichment: 19,75 % - mass of {sup 235}U: 21 kg - fast neutron flux (>0,907 MeV): 6,4.10{sup 14} n.cm{sup -2}.s{sup -1} - thermal neutron flux (<0,625 eV) inside the reflector on aluminium block: 7,3.10{sup 14} n.cm{sup -2}.s{sup -1}. The contributions can be classed into 6 topics: 1) presentation of RJH, 2) site studies, 3) its irradiation capacities, 4) calculation tools for its design (neutronic, photonic, fluid flow and heat transfer), 5) materials (aluminium alloys, mechanical resistance, welding, corrosion resistance), and 6) UMo nuclear fuel (fabrication, reprocessing). (A.C.)

  13. Metabolic Engineering of Plant-derived (E)-β-farnesene Synthase Genes for a Novel Type of Aphid-resistant Genetically Modified Crop Plants

    Institute of Scientific and Technical Information of China (English)

    Xiu-Dao Yu; John Pickett; You-Zhi Ma; Toby Bruce; Johnathan Napier; Huw D.Jones; Lan-Qin Xia

    2012-01-01

    Aphids are major agricultural pests that cause significant yield losses of crop plants each year.Excessive dependence on insecticides for long-term aphid control is undesirable because of the development of insecticide resistance,the potential negative effects on non-target organisms and environmental pollution.Transgenic crops engineered for resistance to aphids via a non-toxic mode of action could be an efficient alternative strategy.(E)-β-Farnesene (EβF) synthases catalyze the formation of EβF,which for many pest aphids is the main component of the alarm pheromone involved in the chemical communication within these species.EβF can also be synthesized by certain plants but is then normally contaminated with inhibitory compounds.Engineering of crop plants capable of synthesizing and emitting EβF could cause repulsion of aphids and also the attraction of natural enemies that use EβF as a foraging cue,thus minimizing aphid infestation.In this review,the effects of aphids on host plants,plants' defenses against aphid herbivory and the recruitment of natural enemies for aphid control in an agricultural setting are briefly introduced.Furthermore,the plant-derived EβF synthase genes cloned to date along with their potential roles in generating novel aphid resistance via genetically modified approaches are discussed.

  14. Production of a plant-derived immunogenic protein targeting ApoB100 and CETP: toward a plant-based atherosclerosis vaccine.

    Science.gov (United States)

    Salazar-Gonzalez, Jorge Alberto; Rosales-Mendoza, Sergio; Romero-Maldonado, Andrea; Monreal-Escalante, Elizabeth; Uresti-Rivera, Edith Elena; Bañuelos-Hernández, Bernardo

    2014-12-01

    In an effort to initiate the development of a plant-based vaccination model against atherosclerosis, a cholera toxin B subunit (CTB)-based chimeric protein was designed to target both ApoB100 and CETP epitopes associated with immunotherapeutic effects in atherosclerosis. Epitopes were fused at the C-terminus of CTB to yield a protein called CTB:p210:CETPe. A synthetic gene coding for CTB:p210:CETPe was successfully transferred to tobacco plants with no phenotypic alterations. Plant-derived CTB:p210:CETPe was expressed and assembled in the pentameric form. This protein retained the target antigenic determinants, as revealed by GM1-ELISA and Western blot analyses. Higher expresser lines reached recombinant protein accumulation levels up to 10 µg/g fresh weight in leaf tissues and these lines carry a single insertion of the transgene as determined by qPCR. Moreover, when subcutaneously administered, the biomass from these CTB:p210:CETPe-producing plants was able to elicit humoral responses in mice against both ApoB100 and CETP epitopes and human serum proteins. These findings evidenced for the first time that atherosclerosis-related epitopes can be expressed in plants retaining immunogenicity, which opens a new path in the molecular farming field for the development of vaccines against atherosclerosis.

  15. Efficacy of plant-derived antimicrobials as antimicrobial wash treatments for reducing enterohemorrhagic Escherichia coli O157:H7 on apples.

    Science.gov (United States)

    Baskaran, Sangeetha Ananda; Upadhyay, Abhinav; Kollanoor-Johny, Anup; Upadhyaya, Indu; Mooyottu, Shankumar; Roshni Amalaradjou, Mary Anne; Schreiber, David; Venkitanarayanan, Kumar

    2013-09-01

    This study investigated the efficacy of 3 GRAS-status, plant-derived antimicrobials (PDAs), trans-cinnamaldehyde (TC), carvacrol (CR), and β-resorcylic acid (BR) applied as an antimicrobial wash for killing Escherichia coli O157:H7 on apples. "Red delicious" apples inoculated with a 5 strain mixture of E. coli O157:H7 were subjected to washing in sterile deionized water containing 0% PDA (control), 0.15% TC, 0.35% TC, 0.15% CR, 0.30% CR, 0.5% BR, or 1% BR for 1, 3, and 5 min at 23 °C in the presence and absence of 1% soil, and surviving pathogen populations on apples were enumerated at each specified time. All PDAs were more effective in reducing E. coli O157:H7 compared to the water wash treatment (P reduced the pathogen by 4- to 5-log CFU/apple in 5 min. Chlorine (1%) was the most effective treatment reducing the pathogen on apples to undetectable levels in 1 min (P water and treatment solutions containing TC and chlorine, in the presence of 1% soil (P usage. © 2013 Institute of Food Technologists®

  16. Conducting correlation seminars in basic sciences at KIST Medical College, Nepal

    Directory of Open Access Journals (Sweden)

    P. Ravi Shankar

    2011-10-01

    Full Text Available KIST Medical College is a new medical school in Lalitpur, Nepal. In Nepal, six basic science subjects are taught together in an integrated organ system-based manner with early clinical exposure and community medicine. Correlation seminars are conducted at the end of covering each organ system. The topics are decided by the core academic group (consisting of members from each basic science department, the Department of Community Medicine, the academic director, and the clinical and program coordinators considering the public health importance of the condition and its ability to include learning objectives from a maximum number of subjects. The learning objectives are decided by individual departments and finalized after the meeting of the core group. There are two student coordinators for each seminar and an evaluation group evaluates each seminar and presenter. Correlation seminars help students revise the organ system covered and understand its clinical importance, promote teamwork and organization, and supports active learning. Correlation seminars should be considered as a learning modality by other medical schools.

  17. Assessing outcomes and perceived benefits of a professional development seminar series.

    Science.gov (United States)

    Zueger, Patrick M; Katz, Norman L; Popovich, Nicholas G

    2014-10-15

    To evaluate the outcomes of alumni who were enrolled in a professional development seminar series during their doctor of pharmacy program. A weekly development seminar series was administered over 5 semesters with the goal of bringing academic advisees together to help develop performance-based abilities, prepare them for entry into the profession after graduation, and provide exposure to different career opportunities. A survey instrument containing 39 Likert-type scale items, 2 open-ended questions, and a 10-item demographic survey was created and content-validated to assess the effect of the seminar series on alumni advisees' perceived outcomes and professional development since their graduation. The survey was electronically forwarded to advisees from the graduating classes of 2005 to 2012, and response data was collected with Qualtrics, a web-based survey service. A total of 36 percent of alumni responded to the survey. Respondents cited exposure to career alternatives and opportunities, development of presentation and communication skills, networking, and the importance of advisor/mentor relationships as benefits of the seminar series. The professional development seminar series has demonstrated a positive impact on alumni advisees' career development and professional outcomes, most notably relating to career path exposure, communication skills, and advisor/mentor relationships.

  18. Meaningful learning: students' perceptions of a new form of case seminar in pathology.

    Science.gov (United States)

    Weurlander, Maria; Masiello, Italo; Söderberg, Magnus; Wernerson, Annika

    2009-06-01

    Student-centred activities have been developed in a pathology course for medical students. This study reports on students' perceptions of a new form of case seminar as a way to learn pathology. The seminar was evaluated through open-ended questionnaires and the data was analysed with a qualitative content analysis approach. All students reported that the case seminar was a positive learning experience. Four aspects of importance for learning were identified: motivational, knowledge construction, contextual and collaborative aspects. The motivational aspects concerned an increase in interest and motivation to learn, while the knowledge construction aspects included enhancing memory formation and facilitation of understanding. The case seminar also seems to help the students relate the textbook knowledge to a real world context and future profession, which can be described as the contextual aspects of learning. According to the students in our study, the work in small groups resulted in positive collaborative aspects of learning. The new case seminar could be an effective teaching and learning activity. It can be used in a traditional course as a complement to lectures and does not require a major change in the course design. It is also well suited for integrated curricula.

  19. Development of a seminar on medical professionalism accompanying the dissection course.

    Science.gov (United States)

    Shiozawa, T; Griewatz, J; Hirt, B; Zipfel, S; Lammerding-Koeppel, M; Herrmann-Werner, A

    2016-11-01

    Medical professionalism is an increasingly important issue in medical education. The dissection course represents a profound experience for undergraduate medical students, which may be suitable to address competencies such as self-reflection and professional behavior. Based on a needs assessment, a seminar on medical professionalism was developed to parallel the dissection course. The conceptual framework for the teaching intervention is experiential learning. Specific learning goals and an interview guideline were formulated. After a pilot run, peer-teaching was introduced. Over three terms (winter 2012/13, 2013/14, 2014/15), an average of 129 students voluntarily participated in the seminar, corresponding to 40% of the student cohort. The evaluation (n=38) shows a majority of students agreeing that the seminar offers support with this extraordinary situation in general and also that the seminar helps them to become first impressions on how to cope with death and dying in their later professional life as a doctor, and, that it also provides them the means to reflect upon their own coping mechanisms. Although not yet implemented as an obligatory course, the seminar is appreciated and positively evaluated. Medical professionalism is an implicit aspect of the dissection course. To emphasize its importance, a teaching intervention to explicitly discuss this topic is advisable. Copyright © 2016 Elsevier GmbH. All rights reserved.

  20. Year-Round Education Dream and Reality. A Report of the National Seminar on Year-Round Education (7th, Denver, Colorado, May 11-14, 1975).

    Science.gov (United States)

    National Council on Year-Round Education.

    This seminar report contains the speeches of the two featured speakers (Dr. Calvin M. Frazier and Dr. Charles E. Silberman), the seminar papers of nearly 90 presenters, and biographical information on the speakers and presenters. (IRT)

  1. Overseas Development of Chinese Industry:Enterprises + Projects——The Second Session of "China Overseas Investment Seminar" is Scheduled to be Held in Beijing November This Year

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    @@ The se cond session of "China Overseas Investment Seminar" will be held on November 2 to 3, 2010 in Beijing's China World Trade Centre. The seminar is organized by China Industrial Overseas Development and Planning Association.

  2. Intensive chemistry seminar, group ability composition, and students' achievement

    Science.gov (United States)

    Fakhreddine, Fatima Hassan

    Intensive Chemistry Seminar (ICS) is an optional, supplemental, honors-level program for chemistry and biochemistry majors. The program emphasizes academic excellence in a challenging yet supportive chemistry rich learning environment that brings together a community of freshmen sharing the same interests. At the heart of ICS are intensive discussion sessions where students work in small groups on worksheets of carefully chosen problems that are direct application of the concepts covered in the main general chemistry course. Central to the success of such learning environment are interactions among students. A key element affecting the depth of such interactions is the relative ability levels of group members. The main focus of this study is to investigate the relationship between. group ability composition and chemistry knowledge acquisition within the ICS sessions. However, the study also compares the achievement of the ICS students with achievement of the non-ICS students. Our data analyses show that chemistry knowledge acquisition within the ICS sessions was significantly enhanced when group members' selection occurred from a Zone of Proximal Development perspective. Our analyses show that students' attitude toward the ICS is overwhelmingly positive and that the benefits of the program extend beyond academic achievement. In practice, our significant results have important applications in college level, cooperative learning practices with objectives similar to those of ICS. Our results show that Vygotsky's ZPD theory seems to be very appropriate for the design and application of cooperative learning environments. Finally, the significant beneficial outcomes of the ICS program should strongly support its integration into the general chemistry I and II majors' sections curriculums.

  3. Biochemistry in an Undergraduate Writing-Intensive First-Year Program: Seminar Courses in Drugs and Bioethics

    Science.gov (United States)

    Mills, Kenneth V.

    2015-01-01

    The College of the Holy Cross offers a universal first-year program called Montserrat, in which first-year students participate in a living-learning experience anchored by a yearlong seminar course. The seminar courses are part of a thematic cluster of four to eight courses; students in the cluster live together in a common dormitory and…

  4. The effects of participating in the 3rd Nordcode seminar - a personal reflection

    DEFF Research Database (Denmark)

    My motivation for co-organise and participate in the 3’rd Nordcode seminar was threefold. Firstly, it gave me an opportunity to get insight into the Nordcode research area, which is defined as communicative product design seen from a Nordic perspective. Secondly, I would learn about state......-of-the-art, current research questions and research methods within this research area. Thirdly, I had a change to meet and discuss with Nordic colleagues. In the invitation to the 3’rd Nordcode seminar “Design communication” the organisers outlined the seminar theme as follows: “Design is about communication in many...... to ensure good design. Topics include: · Semantic and aesthetic functions – How do products communicate? And how do designers communicate their thoughts about design intensions? · User involvement - How can users be involved in the design process? · User centred design - How can user requirements be handled...

  5. Final report from the NKS NordThreat seminar in Asker

    Energy Technology Data Exchange (ETDEWEB)

    Eikelmann, I.M.H.; Selnaes, OE.G. (eds.) (Norwegian Radiation Protection Authority (Norway))

    2009-11-15

    Changes in the international security environment have lead to an increased attention towards the need to revise various threat assessments in the Nordic countries. Together with recent events such as incidents at Nordic nuclear power plants, orphan sources and accidents involving nuclear powered vessels, this has given a good opportunity for an exchange of information and opinions. The NKS-B NordThreat seminar took place at Sem gjestegaard in Asker outside Oslo, Norway on 30 - 31 October 2008. Main topics in the seminar were: 1) National threat assessments 2) Potential hazards 3) Experience from previous incidents 4) Public perception of nuclear and radiological threats and information challenges 5) Challenges for future preparedness. There were about 40 participants at the seminar. These were mainly members of the NKS organisations, invited speakers and representatives from various Norwegian emergency preparedness organisations. (author)

  6. SEMINAR ABOUT SERIOUS GAMES AND VIRTUAL WORLDS: An Experience of International Collaboration And Reflection

    Directory of Open Access Journals (Sweden)

    Wolfram LAASER

    2011-08-01

    Full Text Available The educational possibilities of ICT, dizzying and exponentially growing every day, offer multiple alternatives of mediation for teaching, learning and communication.Thus, the inclusion of video games and virtual worlds into educational context represents a qualitative leap that claims to significantly boost ways of communication and knowledge representation of the scenarios involved. Aware of this reality, in the framework of the Master of Technology Enhanced Learning at the National University of Cordoba, Argentina, a virtual seminar was offered to students to address the issue on the basis of invited lectures of worldwide recognized experts. The format chosen for the seminar allowed the treatment of subjects not only through reading assignments and web quests to be discussed collaboratively but also included the state of the art experience of developers working in the field. The paper describes didactic design and technical solutions of the seminar format.

  7. Vertical and horizontal liners. Expert seminar; Vertikale und horizontale Abdichtungssysteme. Fachseminar

    Energy Technology Data Exchange (ETDEWEB)

    Rosenberg, M.; Schulz, T. [comps.

    2000-07-01

    The seminar presented new findings in the fields of surface coverings and alternative liners, vertical liners (with a contribution on developments in Great Britain), and basic constructive problems of liner systems. Another session discussed problems, experience and developments of sealing walls, especially quality assurance measures during sealing wall construction. Apart from presenting a status report, the seminar also intended to provide a basis for an exchange of experience between the attendants. [German] Ein Schwerpunkt des diesjaehrigen Deponieseminars ist die Darstellung von neuen Erkenntnissen und Erfahrungen mit Oberflaechenabdichtungen und mit alternativen Dichtungssystemen fuer Deponien. Weiterhin werden vertikale Abdichtungen behandelt, fuer die ein Beitrag ueber Entwicklungen in Grossbritannien vorliegt sowie grundsaetzliche konstruktive Fragen zu Abdichtungssystemen. Der weitere Seminarschwerpunkt behandelt Problemstellungen, Erfahrungen und Entwicklungen der Dichtwandtechnologie, insbesondere Qualitaetssicherungsmassnahmen waehrend des Dichtwandbaus. Das Ziel des Seminars ist es, einerseits den Stand der Technik und der Forschung darzustellen, andererseits aber die Moeglichkeit zu bieten, Erfahrungen und Informationen auszutauschen. (orig.)

  8. Topicality and the Structure of Interactive Talk in Face-to-Face Seminar Discussions: Implications for Research in Distributed Learning Media

    Science.gov (United States)

    Gibson, Will; Hall, Andy; Callery, Peter

    2006-01-01

    This article examines the structure of topic movement within face-to-face postgraduate university seminar discussion forums through a conversation analytic approach. The analysis of 12 audio recordings of seminars showed that in spite of clear differences in the management style of sessions by seminar leaders there were important consistencies in…

  9. GammaSem Proceedings. A Nordic seminar for users of gamma spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Straalberg, E. (ed.) (Institute for Energy Technolgy (Norway)); Berg, K. (National Institute of Radiation Protection (Denmark)); Dowdall, M. (Norwegian Radiation Protection Authority (Norway)) (and others)

    2010-11-15

    The project GammaSem was proposed to the NKS in 2008. The aim of the project was to arrange two seminars for users of gamma spectrometry, in 2009 and 2010. The seminars were meant to provide a forum for discussions and sharing of information on practical issues concerning gamma spectrometry and initiate a network of gamma spectrometry users in the Nordic countries. Such a Nordic network should strengthen the collaboration between laboratories and improve all participants' competence in practical gamma spectrometry. Both seminars' focus was practical challenges met by the users themselves, rather than theoretical matters. Scientists and users of gamma spectrometry from all five Nordic countries were invited to the seminar, as well as scientist from the Baltic countries. A total of 65 people signed up for GammaSem 2010; representing 30 different universities, commercial companies, research institutes and authorities. The working group concept as presented at last year's GammaSem, has not worked out as intended. The reason for this is probably because most of the laboratories that signed up to join the working groups, signed up because they wanted to learn more about the different subjects. In combination with the fact that no funding was made available for the working groups, it was difficult to establish goals on what to achieve. None of the working groups applied for funding from the NKS (or elsewhere) to establish separate projects. There is a big need for more cooperation and for training within the field of gamma spectrometry. This fact has been proved through these two seminars, both by the many different topics that have been discussed, but also by the huge interest for participating in the suggested series of workshop. The GammaSem seminars have thus provided a much welcomed starting point for a broader Nordic collaboration. (Author)

  10. Report on the seminar: An investigation of Calvin' s principles of Biblical interpretation

    Directory of Open Access Journals (Sweden)

    B. G. Armstrong

    1998-01-01

    Full Text Available This article serves as a report on the seminar on 'Calvin the Preacher', held at the University of Pretoria during the Fifth South-African Congres of Calvin Research. In the seminar, where various examples of Calvin's interpretation were discussed, the basic principles of Calvin's method were enumerated.  Although the discussions ranged far and wide, a valuable insight was gained in Calvin's methods. At the same time it became clear that Calvin's principles of Biblical interpretation had to receive more attention.

  11. Workflow in the operating room: review of Arrowhead 2004 seminar on imaging and informatics (Invited Paper)

    Science.gov (United States)

    Lemke, Heinz U.; Ratib, Osman M.; Horii, Steven C.

    2005-04-01

    This review paper is based on the 2004 UCLA Seminar on Imaging and Informatics (http://www.radnet.ucla.edu/Arrowhead2004/) which is a joint endeavour between the UCLA and the CARS organization, focussing on workflow analysis tools and the digital operating room. Eleven specific presentations of the Arrowhead Seminar have been summarized in this review referring to redesigning perioperative care for a high velocity OR, intraoperative ultrasound process and model, surgical workflow and surgical PACS, an integrated view , interactions in the surgical OR, workflow automation strategies and target applications, visualisation solutions for the operating room, navigating the fifth dimension, and design of digital operating rooms and interventional suites

  12. Pacific Armies Management Seminar III, held 14-18 January 1980, Honolulu, Hawaii.

    Science.gov (United States)

    1980-01-01

    Panel Discussion: "Operations Management" 1830-2130 Optional Dinner and Show - Tama’s Hula Nani Show, Hale Koa Hotel Thursday, 17 Jan 80 0755- Call to...Hale Koa Hotel , Major General Wolff, Commander, US Army Western Command, Closing Remarks 10 PAC?..IC ARMIES 14ANAGEMIENT SE~ INAR- t 1.4-18 Janu1ary...Armies Management Seminar. 47 PANEL ASSIGNMENTS PACIFIC ARMIES MANGEMENT SEMINAR - III 14-18 January 1980 PANEL 1 PANEL II *Col THAWAN Sawaengpan *Col

  13. Seminar on Cooperation Between Chinese And Spanish Enterprises Held in Seville

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    <正>On November 29,2007 the Seminar on Cooperation between Chinese and Spanish Enterprises jointly sponsored by the CPAFFC,the Chinese Committee of the China-Spain Forum(CSF) and the Autonomous Government of Andalucia Region of Spain was held in the Office of the president of Andalucia in Seville,capital of the region.The seminar,an extension of the Fourth Meeting of the China-Spain Forum,aimed at boosting cooperation between the localities and small and medium-sized enterprises of the two countries in a practical and innovative spirit.

  14. Advanced energy sources and conversion techniques. Proceedings of a seminar. Volume 1. [35 papers

    Energy Technology Data Exchange (ETDEWEB)

    None

    1958-11-01

    The Seminar was organized as a series of tutorial presentations and round table discussions on a technical level to implement the following: (a) to identify and explore present and projected needs for energy sources and conversion techniques for military applications; (b) to exchange information on current and planned efforts in these fields; (c) to examine the effect of anticipated scientific and technological advances on these efforts; and (d) to present suggested programs aimed at satisfying the military needs for energy sources and conversion techniques. Volume I contains all of the unclassified papers presented at the Seminar. (W.D.M.)

  15. Seminar on Internationalization of China National Technical Standards Was Held in Beijing

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    @@ On May 26th, the seminar on the internationalization of China national technical standards, hosted by the professional management office on research of important technical standards, jointly organized and implemented by Ministry of Science and Technology of the People'Republic of China, General Administration for Quality Supervision, Inspection and Quarantine of P.R. China (AQSIQ) and Standardization Administration of China (SAC), was held in Beijing. The theme of the seminar was to explore the road for the internationalization of China national technical standards.

  16. Rumen microbial abundance and fermentation profile during severe subacute ruminal acidosis and its modulation by plant derived alkaloids in vitro.

    Science.gov (United States)

    Mickdam, Elsayed; Khiaosa-Ard, Ratchaneewan; Metzler-Zebeli, Barbara U; Klevenhusen, Fenja; Chizzola, Remigius; Zebeli, Qendrim

    2016-06-01

    Rumen microbiota have important metabolic functions for the host animal. This study aimed at characterizing changes in rumen microbial abundances and fermentation profiles using a severe subacute ruminal acidosis (SARA) in vitro model, and to evaluate a potential modulatory role of plant derived alkaloids (PDA), containing quaternary benzophenanthridine and protopine alkaloids, of which sanguinarine and chelerythrine were the major bioactive compounds. Induction of severe SARA strongly affected the rumen microbial composition and fermentation variables without suppressing the abundance of total bacteria. Protozoa and fungi were more sensitive to the low ruminal pH condition than bacteria. Induction of severe SARA clearly depressed degradation of fiber (P < 0.001), which came along with a decreased relative abundance of fibrolytic Ruminococcus albus and Fibrobacter succinogenes (P < 0.001). Under severe SARA conditions, the genus Prevotella, Lactobacillus group, Megasphaera elsdenii, and Entodinium spp. (P < 0.001) were more abundant, whereas Ruminobacter amylophilus was less abundant. SARA largely suppressed methane formation (-70%, P < 0.001), although total methanogenic 16S rRNA gene abundance was not affected. According to principal component analysis, Methanobrevibacter spp. correlated to methane concentration. Addition of PDA modulated ruminal fermentation under normal conditions such as enhanced (P < 0.05) concentration of total SCFA, propionate and valerate, and increased (P < 0.05) degradation of crude protein compared with the unsupplemented control diet. Our results indicate strong shifts in the microbial community during severe SARA compared to normal conditions. Supplementation of PDA positively modulates ruminal fermentation under normal ruminal pH conditions.

  17. Assessing saffron (Crocus sativus L.) adulteration with plant-derived adulterants by diffuse reflectance infrared Fourier transform spectroscopy coupled with chemometrics.

    Science.gov (United States)

    Petrakis, Eleftherios A; Polissiou, Moschos G

    2017-01-01

    Saffron, the dried red stigmas of the plant Crocus sativus L., is well-known as one of the most important and expensive spices worldwide. It is thus highly susceptible to fraudulent practices that employ, among others, plant-derived adulterants. This study presents an application of diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) and chemometric techniques for evaluating adulteration of saffron with six characteristic adulterants of plant origin, i.e. C. sativus stamens, calendula, safflower, turmeric, buddleja, and gardenia. The proposed method involved a three-step process for the detection of adulteration as well as for the identification and quantification of adulterants. Partial least squares discriminant analysis (PLS-DA) was applied to perform authentication of saffron based on mid-infrared fingerprints (4000-600cm(-1)), resulting in 99% correct classification of pure saffron and saffron adulterated at 5-20% (w/w) levels. Adulterant identification in positive samples was performed with high sensitivity and specificity by a six-class PLS-DA model, with spectroscopic data from the region 2000-600cm(-1). Subsequently, partial least squares (PLS) regression models were built for the quantification of each adulterant. By using synergy interval PLS (siPLS) for variable selection, models with improved performance were developed, with detection limits ranging from 1.0% to 3.1% (w/w). The results obtained illustrate that this strategy based on DRIFTS has the potential to complement existing methodologies for the rapid and cost-effective assessment of typical saffron frauds.

  18. Heat-precipitation allows the efficient purification of a functional plant-derived malaria transmission-blocking vaccine candidate fusion protein.

    Science.gov (United States)

    Beiss, Veronique; Spiegel, Holger; Boes, Alexander; Kapelski, Stephanie; Scheuermayer, Matthias; Edgue, Gueven; Sack, Markus; Fendel, Rolf; Reimann, Andreas; Schillberg, Stefan; Pradel, Gabriele; Fischer, Rainer

    2015-07-01

    Malaria is a vector-borne disease affecting more than two million people and accounting for more than 600,000 deaths each year, especially in developing countries. The most serious form of malaria is caused by Plasmodium falciparum. The complex life cycle of this parasite, involving pre-erythrocytic, asexual and sexual stages, makes vaccine development cumbersome but also offers a broad spectrum of vaccine candidates targeting exactly those stages. Vaccines targeting the sexual stage of P. falciparum are called transmission-blocking vaccines (TBVs). They do not confer protection for the vaccinated individual but aim to reduce or prevent the transmission of the parasite within a population and are therefore regarded as an essential tool in the fight against the disease. Malaria predominantly affects large populations in developing countries, so TBVs need to be produced in large quantities at low cost. Combining the advantages of eukaryotic expression with a virtually unlimited upscaling potential and a good product safety profile, plant-based expression systems represent a suitable alternative for the production of TBVs. We report here the high level (300 μg/g fresh leaf weight (FLW)) transient expression in Nicotiana benthamiana leaves of an effective TBV candidate based on a fusion protein F0 comprising Pfs25 and the C0-domain of Pfs230, and the implementation of a simple and cost-effective heat treatment step for purification that yields intact recombinant protein at >90% purity with a recovery rate of >70%. The immunization of mice clearly showed that antibodies raised against plant-derived F0 completely blocked the formation of oocysts in a malaria transmission-blocking assay (TBA) making F0 an interesting TBV candidate or a component of a multi-stage malaria vaccine cocktail.

  19. Comparative efficacy of plant-derived essential oils for managing ambrosia beetles (Coleoptera: Curculionidae: Scolytinae) and their corresponding mass spectral characterization.

    Science.gov (United States)

    Ranger, Christopher M; Reding, Michael E; Oliver, Jason B; Schultz, Peter B; Moyseenko, James J; Youssef, Nadeer

    2011-10-01

    Ambrosia beetles (Coleoptera: Curculionidae: Scolytinae) pose a significant challenge to producers of ornamental nursery stock. Conventional insecticides are commonly used for management purposes, but plant-derived essential oils also may discourage ambrosia beetles from initiating attacks. To identify promising commercially available products, field-based efficacy trials were conducted in Ohio in 2009 and 2010 with the following products: Armorex (Soil Technologies), Cinnacure (Proguard, Inc.), EcoTrol (EcoSMART Technologies, Inc.), and Veggie Pharm (Pharm Solutions, Inc.). Potted Magnolia virginiana L. were first injected with 75 ml of 5% ethanol to ensure ambrosia beetle pressure on experimental trees. Mixtures of each product (10% in water) and a water control were applied until runoff and attacks occurring under field conditions were quantified at 1, 4, 7, and 14 d after treatment (DAT). Ambrosia beetle attacks generally increased over time but at differing rates depending on the particular treatment. In 2009, Armorex and Veggie Pharm were associated with the lowest cumulative attacks 14 DAT. In 2010, Armorex and Cinnacure were associated with the fewest attacks 14 DAT. Solid phase microextraction-gas chromatography-mass spectrometry was used to characterize the volatile compounds associated with each product. Allyl isothiocyanate, a compound with known repellent and insecticidal properties, was unique and predominant in Armorex. These experiments identified commercially available botanicals containing plant essential oils with activity against ambrosia beetles, along with demonstrating the usefulness of ethanol-injection to ensure ambrosia beetle pressure under field conditions. Characterizing the constituents of efficacious botanically based products could also lead to the development of improved botanical insecticides.

  20. Optimized Blanching Reduces the Host Cell Protein Content and Substantially Enhances the Recovery and Stability of Two Plant-Derived Malaria Vaccine Candidates.

    Science.gov (United States)

    Menzel, Stephan; Holland, Tanja; Boes, Alexander; Spiegel, Holger; Bolzenius, Johanna; Fischer, Rainer; Buyel, Johannes F

    2016-01-01

    Plants provide an advantageous expression platform for biopharmaceutical proteins because of their low pathogen burden and potential for inexpensive, large-scale production. However, the purification of target proteins can be challenging due to issues with extraction, the removal of host cell proteins (HCPs), and low expression levels. The heat treatment of crude extracts can reduce the quantity of HCPs by precipitation thus increasing the purity of the target protein and streamlining downstream purification. In the overall context of downstream process (DSP) development for plant-derived malaria vaccine candidates, we applied a design-of-experiments approach to enhance HCP precipitation from Nicotiana benthamiana extracts generated after transient expression, using temperatures in the 20-80°C range, pH values of 3.0-8.0 and incubation times of 0-60 min. We also investigated the recovery of two protein-based malaria vaccine candidates under these conditions and determined their stability in the heat-treated extract while it was maintained at room temperature for 24 h. The heat precipitation of HCPs was also carried out by blanching intact plants in water or buffer prior to extraction in a blender. Our data show that all the heat precipitation methods reduced the amount of HCP in the crude plant extracts by more than 80%, simplifying the subsequent DSP steps. Furthermore, when the heat treatment was performed at 80°C rather than 65°C, both malaria vaccine candidates were more stable after extraction and the recovery of both proteins increased by more than 30%.

  1. Intranasal vaccination with a plant-derived H5 HA vaccine protects mice and ferrets against highly pathogenic avian influenza virus challenge.

    Science.gov (United States)

    Major, Diane; Chichester, Jessica A; Pathirana, Rishi D; Guilfoyle, Kate; Shoji, Yoko; Guzman, Carlos A; Yusibov, Vidadi; Cox, Rebecca J

    2015-01-01

    Highly pathogenic avian influenza H5N1 infection remains a public health threat and vaccination is the best measure of limiting the impact of a potential pandemic. Mucosal vaccines have the advantage of eliciting immune responses at the site of viral entry, thereby preventing infection as well as further viral transmission. In this study, we assessed the protective efficacy of hemagglutinin (HA) from the A/Indonesia/05/05 (H5N1) strain of influenza virus that was produced by transient expression in plants. The plant-derived vaccine, in combination with the mucosal adjuvant (3',5')-cyclic dimeric guanylic acid (c-di-GMP) was used for intranasal immunization of mice and ferrets, before challenge with a lethal dose of the A/Indonesia/05/05 (H5N1) virus. Mice vaccinated with 15 μg or 5 μg of adjuvanted HA survived the viral challenge, while all control mice died within 10 d of challenge. Vaccinated animals elicited serum hemagglutination inhibition, IgG and IgA antibody titers. In the ferret challenge study, all animals vaccinated with the adjuvanted plant vaccine survived the lethal viral challenge, while 50% of the control animals died. In both the mouse and ferret models, the vaccinated animals were better protected from weight loss and body temperature changes associated with H5N1 infection compared with the non-vaccinated controls. Furthermore, the systemic spread of the virus was lower in the vaccinated animals compared with the controls. Results presented here suggest that the plant-produced HA-based influenza vaccine adjuvanted with c-di-GMP is a promising vaccine/adjuvant combination for the development of new mucosal influenza vaccines.

  2. Optimized blanching reduces the host cell protein content and substantially enhances the recovery and stability of two plant derived malaria vaccine candidates

    Directory of Open Access Journals (Sweden)

    Stephan eMenzel

    2016-02-01

    Full Text Available Plants provide an advantageous expression platform for biopharmaceutical proteins because of their low pathogen burden and potential for inexpensive, large-scale production. However, the purification of target proteins can be challenging due to issues with extraction, the removal of host cell proteins (HCPs, and low expression levels. The heat treatment of crude extracts can reduce the quantity of HCPs by precipitation thus increasing the purity of the target protein and streamlining downstream purification. In the overall context of downstream process development for plant-derived malaria vaccine candidates, we applied a design-of-experiments approach to enhance HCP precipitation from Nicotiana benthamiana extracts generated after transient expression, using temperatures in the 20−80°C range, pH values of 3.0−8.0 and incubation times of 0−60 min. We also investigated the recovery of two protein-based malaria vaccine candidates under these conditions and determined their stability in the heat-treated extract while it was maintained at room temperature for 24 h. The heat precipitation of HCPs was also carried out by blanching intact plants in water or buffer prior to extraction in a blender. Our data show that all the heat precipitation methods reduced the amount of HCP in the crude plant extracts by more than 80%, simplifying the subsequent downstream processing steps. Furthermore, when the heat treatment was performed at 80°C rather than 65°C, both malaria vaccine candidates were more stable after extraction and the recovery of both proteins increased by more than 30%.

  3. Comparative analysis of mosquito (Diptera: Culicidae: Aedes aegypti Liston) responses to the insecticide Temephos and plant derived essential oil derived from Piper betle L.

    Science.gov (United States)

    Vasantha-Srinivasan, Prabhakaran; Senthil-Nathan, Sengottayan; Ponsankar, Athirstam; Thanigaivel, Annamalai; Edwin, Edward-Sam; Selin-Rani, Selvaraj; Chellappandian, Muthiah; Pradeepa, Venkatraman; Lija-Escaline, Jalasteen; Kalaivani, Kandaswamy; Hunter, Wayne B; Duraipandiyan, Veeramuthu; Al-Dhabi, Naif Abdullah

    2017-05-01

    Resistance to treatments with Temephos or plant derived oil, Pb-CVO, between a field collected Wild Strain (WS) and a susceptible Laboratory Strain (LS) of Ae. aegypti were measured. The Temephos (0.1mg/L) showed the greatest percentage of mosquito mortality compared to Pb-CVO (1.5mg/L) in LS Ae. aegypti. However, WS Ae. aegypti was not significantly affected by Temephos (0.1mg/L) treatment compare to the Pb-CVO (1.5mg/L). However, both strains (LS and WS) when treated with Pb-CVO (1.5mg/L) displayed steady larval mortality rate across all instars. The LC50 of Temephos was 0.027mg in LS, but increased in WS to 0.081mg/L. The LC50 of Pb-CVO treatment was observed at concentrations of 0.72 and 0.64mg/L for LS and WS strains respectively. The enzyme level of α- and β-carboxylesterase was reduced significantly in both mosquito strains treated with Pb-CVO. Whereas, there was a prominent deviation in the enzyme ratio observed between LS and WS treated with Temephos. The GST and CYP450 levels were upregulated in the LS, but decreased in WS, after treatment with Temephos. However, treatment with Pb-CVO caused both enzyme levels to increase significantly in both the strains. Visual observations of the midgut revealed cytotoxicity from sub-lethal concentrations of Temephos (0.04mg/L) and Pb-CVO (1.0mg/L) in both strains of Ae. aegypti compared to the control. The damage caused by Temephos was slightly less in WS compared to LS mosquito strains. Copyright © 2017 Elsevier Inc. All rights reserved.

  4. Inactivation of pathogenic viruses by plant-derived tannins: strong effects of extracts from persimmon (Diospyros kaki on a broad range of viruses.

    Directory of Open Access Journals (Sweden)

    Kyoko Ueda

    Full Text Available Tannins, plant-derived polyphenols and other related compounds, have been utilized for a long time in many fields such as the food industry and manufacturing. In this study, we investigated the anti-viral effects of tannins on 12 different viruses including both enveloped viruses (influenza virus H3N2, H5N3, herpes simplex virus-1, vesicular stomatitis virus, Sendai virus and Newcastle disease virus and non-enveloped viruses (poliovirus, coxsachievirus, adenovirus, rotavirus, feline calicivirus and mouse norovirus. We found that extracts from persimmon (Diospyros kaki, which contains ca. 22% of persimmon tannin, reduced viral infectivity in more than 4-log scale against all of the viruses tested, showing strong anti-viral effects against a broad range of viruses. Other tannins derived from green tea, acacia and gallnuts were effective for some of the viruses, while the coffee extracts were not effective for any of the virus. We then investigated the mechanism of the anti-viral effects of persimmon extracts by using mainly influenza virus. Persimmon extracts were effective within 30 seconds at a concentration of 0.25% and inhibited attachment of the virus to cells. Pretreatment of cells with the persimmon extracts before virus infection or post-treatment after virus infection did not inhibit virus replication. Protein aggregation seems to be a fundamental mechanism underlying the anti-viral effect of persimmon tannin, since viral proteins formed aggregates when purified virions were treated with the persimmon extracts and since the anti-viral effect was competitively inhibited by a non-specific protein, bovine serum albumin. Considering that persimmon tannin is a food supplement, it has a potential to be utilized as a safe and highly effective anti-viral reagent against pathogenic viruses.

  5. Inactivation of pathogenic viruses by plant-derived tannins: strong effects of extracts from persimmon (Diospyros kaki) on a broad range of viruses.

    Science.gov (United States)

    Ueda, Kyoko; Kawabata, Ryoko; Irie, Takashi; Nakai, Yoshiaki; Tohya, Yukinobu; Sakaguchi, Takemasa

    2013-01-01

    Tannins, plant-derived polyphenols and other related compounds, have been utilized for a long time in many fields such as the food industry and manufacturing. In this study, we investigated the anti-viral effects of tannins on 12 different viruses including both enveloped viruses (influenza virus H3N2, H5N3, herpes simplex virus-1, vesicular stomatitis virus, Sendai virus and Newcastle disease virus) and non-enveloped viruses (poliovirus, coxsachievirus, adenovirus, rotavirus, feline calicivirus and mouse norovirus). We found that extracts from persimmon (Diospyros kaki), which contains ca. 22% of persimmon tannin, reduced viral infectivity in more than 4-log scale against all of the viruses tested, showing strong anti-viral effects against a broad range of viruses. Other tannins derived from green tea, acacia and gallnuts were effective for some of the viruses, while the coffee extracts were not effective for any of the virus. We then investigated the mechanism of the anti-viral effects of persimmon extracts by using mainly influenza virus. Persimmon extracts were effective within 30 seconds at a concentration of 0.25% and inhibited attachment of the virus to cells. Pretreatment of cells with the persimmon extracts before virus infection or post-treatment after virus infection did not inhibit virus replication. Protein aggregation seems to be a fundamental mechanism underlying the anti-viral effect of persimmon tannin, since viral proteins formed aggregates when purified virions were treated with the persimmon extracts and since the anti-viral effect was competitively inhibited by a non-specific protein, bovine serum albumin. Considering that persimmon tannin is a food supplement, it has a potential to be utilized as a safe and highly effective anti-viral reagent against pathogenic viruses.

  6. 2015 Liquid Crystals Gordon Research Conference and Gordon Research Seminar

    Science.gov (United States)

    2015-10-20

    physics, chemistry , and biology of systems that possess liquid crystallinity will be emphasized. The conference will bring together an outstanding group...supramolecular chemistry and multifunctional materials, (iii) liquid crystalline glasses and metastable phases, (iv) liquid crystallinity in biological...USA) "Templating Polymers with Lyotropic Liquid Crystals via Photopolymerization Using a Gemini Surfactant " 11:55 am - 12:00 pm Discussion 12:00 pm

  7. Essential Oils from Thyme (Thymus vulgaris): Chemical Composition and Biological Effects in Mouse Model.

    Science.gov (United States)

    Vetvicka, Vaclav; Vetvickova, Jana

    2016-12-01

    Thymus species are popular spices and contain volatile oils as main chemical constituents. Recently, plant-derived essential oils are gaining significant attention due to their significant biological activities. Seven different thymus-derived essential oils were compared in our study. First, we focused on their chemical composition, which was followed up by testing their effects on phagocytosis, cytokine production, chemotaxis, edema inhibition, and liver protection. We found limited biological activities among tested oils, with no correlation between composition and biological effects. Similarly, no oils were effective in every reaction. Based on our data, the tested biological use of these essential oils is questionable.

  8. This Is Not an Article: A Reflection on Creative Research Dialogues (This Is Not a Seminar)

    Science.gov (United States)

    Adams, Lyndall; Kueh, Christopher; Newman-Storen, Renee; Ryan, John

    2015-01-01

    This is Not a Seminar (TINAS) is a multidisciplinary forum established in 2012 at Edith Cowan University (ECU) in Australia to support practice-led and practice-based Higher Degree by Research students. The Faculty of Education and Arts at ECU includes cohorts of postgraduate research students in, for example, performance, design, writing and…

  9. Research Challenges in Intervehicular Communication: Lessons of the 2010 Dagstuhl Seminar

    NARCIS (Netherlands)

    Dressler, Falko; Kargl, Frank; Ott, Jörg; Tonguz, Ozan K.; Wischof, Lars

    2011-01-01

    Intervehicle communication has become an extremely hot topic in networking research, opening up new research challenges well beyond those of classical mobile ad hoc network research. In October 2010, a Dagstuhl seminar has been organized bringing together many of the internationally leading experts

  10. Eesti ja läti vana kirjakeele seminar / Väino Klaus

    Index Scriptorium Estoniae

    Klaus, Väino, 1949-

    2003-01-01

    Seminar "Läti ja eesti kirjakeele ühised juured" 18. 10. 2002 Eesti Keele Instituudis, kus räägiti varase kirjakeele tekke sarnastest mõjutajatest, Piibli ja muu vaimuliku kirjanduse tõlkimisest ning latgale kirjakeelest

  11. THE DEVELOPMENT OF COMMUNICATIVE COMPETENCES VIA CROSS-CURRICULAR ECTS SEMINARS

    Directory of Open Access Journals (Sweden)

    María Luisa Pérez Cañado

    2011-04-01

    Full Text Available This article describes an innovative experience in the development of cross-curricular generic and subject-specific competencies carried out via a system of ECTS seminars which has been developed within the degree in English Philology at the University of Jaén during the academic year 2008-2009. The aim of these seminars has been to reinforce coordination amongst professors, to overcome the oftentimes worrying individualism which characterizes teaching practices at tertiary level, and to make the transition from the transmission of information model based on ex-cathedra lecturing to a more critical and significant learning based on competencies and not merely on contents. After justifying the need for an experience of this type and describing its development, contents, and evaluation, the article goes on to present the results of the descriptive study which has accompanied it. The outcomes of the investigation have revealed that the ECTS seminar system has been highly beneficial for the participating students. The latter have been aware of the existence, development, and usefulness of a set of generic and specific competencies which are essential for the English philologist. We consider that, in our immediate context, these ECTS seminars have constituted an important first step in the integration, teaching, and assessment of competencies in the curriculum.

  12. Proceedings of the seminar on leak before break in reactor piping and vessels

    Energy Technology Data Exchange (ETDEWEB)

    Faidy, C. [ed.] [Electricite de France, Villeurbanne (France); Gilles, P. [ed.] [Framatome, Paris (France)

    1997-04-01

    The objective of the seminar was to present the current state of the art in Leak-Before-Break (LBB) methodology development, validation, and application in an international forum. With particular emphasis on industrial applications and regulatory policies, the seminar provided an opportunity to compare approaches, experiences, and codifications developed by different countries. The seminar was organized into four topic areas: status of LBB applications; technical issues in LBB methodology; complementary requirements (leak detection and inspection); LBB assessment and margins. As a result of this seminar, an improved understanding of LBB gained through sharing of different viewpoints from different countries, permits consideration of: simplified pipe support design and possible elimination of loss-of-coolant-accident (LOCA) mechanical consequences for specific cases; defense-in-depth type of applications without support modifications; support of safety cases for plants designed without the LOCA hypothesis. In support of these activities, better estimates of the limits to the LBB approach should follow, as well as an improvement in codifying methodologies. Selected papers are indexed separately for inclusion in the Energy Science and Technology Database.

  13. In Search of Ernest Hemingway: A Model for Teaching a Literature Seminar.

    Science.gov (United States)

    Workman, Brooke

    Intended for use every day for a semester, this secondary seminar handbook provides a schedule, lesson plans, materials for classroom distribution, and a bibliography for a course designed to teach critical reading and basic writing skills through an in-depth study of Ernest Hemingway. Because the course requires that students write seven position…

  14. A Feminist Approach to Teaching Community Psychology: The Senior Seminar Project

    Science.gov (United States)

    Silva, Janelle M.

    2015-01-01

    Since the 1960s, women's centers on college campuses have provided a wide variety of resources. Unfortunately, not all colleges and universities house women's centers, despite the need for such spaces for their students. In this article, Janelle M. Silva describes a senior seminar grounded in feminist pedagogy and community psychology principles…

  15. China: Tradition and Transformation. Curriculum Projects. Fulbright-Hays Summer Seminars Abroad Program, 2002 (China).

    Science.gov (United States)

    National Committee on United States-China Relations, New York, NY.

    This collection of 15 curriculum projects is the result of a summer seminar in China for teachers and scholars. Projects in the collection are: (1) "Perspectives on Modern Political/Social Issues in China" (Sandy Conlon); (2) "Ancient History X Projects/China" (Michael Corey); (3) "Education and Development: China, a Case Study" (Marcia J. Frost);…

  16. Negotiating Accountability during Student Teaching: The Influence of an Inquiry-Based Student Teaching Seminar

    Science.gov (United States)

    Cuenca, Alexander

    2014-01-01

    Drawing on the work of Russian literary critic, Mikhail Bakhtin, this article explores how an inquiry-based social studies student teaching seminar helped three preservice teachers negotiate the pressures of standards-based reforms during student teaching. The author first examines how initial perceptions of standardization and high-stakes testing…

  17. Findings from an Independent Evaluation of the AMNH's Online Seminars on Science Course: "Sharks and Rays"

    Science.gov (United States)

    Inverness Research, 2008

    2008-01-01

    Inverness Research studied the American Museum of Natural History (AMNH) Seminars on Science program for eight years, from its inception in 1998 to 2006. This paper presents teacher survey ratings for Sharks and Rays, along with profiles of three teachers who took the course. Fifteen course takers from nine states who responded to the annual…

  18. Mehr als eine politische Lehrstunde : V. Baltische Studenten-Seminar in Darmstadt

    Index Scriptorium Estoniae

    2010-01-01

    16.-21. novembrini 2010 toimunud viienda balti üliõpilasseminari keskpunktis oli teemadekompleks demokraatiast Baltimaades. Arutleti ka demokraatiakogemuse üle kahel viimasel sajandil Saksamaal. Jugendherberges alanud seminar jätkus Darmstadtis ja lõppes Saksa-Balti Seltsi 60nda juubeli tähistamisega. Viie päeva temaatika haaras Baltimaade ja Euroopa kultuuri, poliitikat ja ajalugu

  19. Seminar on Adult Education: ED925.33, Winter Quarter 1971. Bibliography.

    Science.gov (United States)

    Ohliger, John

    Beginning with the seminar textbook itself ("Pedagogy of the Oppressed," by Paulo Freire), this annotated bibliography goes on to list and describe (usually through excerpted passages) 45 articles and other works by or about Ivan Illich, his colleagues, and the Center for Intercultural Documentation at Cuernavaca, Mexico. Fifty other…

  20. Proceedings Norwegian-Polish Seminar on Measures to Reduce the Pollution of the Environment

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-07-01

    The report presents papers presented at the Norwegian-Polish Seminar on Measures to Reduce the Pollution of the Environment held in Oslo on the 25th August 1998. The report contains also a chairman report on discussions during the meeting. (Author)