WorldWideScience

Sample records for planning specification design

  1. Buffer planning for application-specific networks-on-chip design

    Institute of Scientific and Technical Information of China (English)

    YIN ShouYi; LIU LeiBo; WEI ShaoJun

    2009-01-01

    Networks-on-chip (NoC) is a promising communication architecture for next generation SoC. The size of buffer used In on-chip routers impacts the silicon area and power consumption of NoC dominantly. It is important to plan the total buffer-size and each muter buffer-allocation carefully for an efficient NoC design. In this paper, we propose two buffer planning algorithms for application-specific NoC design. More precisely, given the traffic parameters and performance constraints of target application, the proposed algorithms automatically determine minimal buffer budget and assign the buffer depth for each input channel in different routers. The experimental results show that the proposed algorithms can significantly reduce total buffer usage and guarantee the performance requirements.

  2. Model Commissioning Plan and Guide Specifications

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-03-01

    The objectives of Model Commissioning Plan and Guide Specifications are to ensure that the design team applies commissioning concepts to the design and prepares commissioning specifications and a commission plan for inclusion in the bid construction documents.

  3. Effective Design and Planning Specification of Low Impact Development Practices Using Water Management Analysis Module (WMAM: Case of Malaysia

    Directory of Open Access Journals (Sweden)

    Kamal Ahmed

    2017-02-01

    Full Text Available Developers are increasingly looking for the best management practices to reduce the risk of floods in rapidly growing urban areas. Low impact development (LID is regarded as one of the most suitable solutions for urban stormwater management and thus the U.S. EPA’s (Environmental Protection Agency SWMM5.1 (Storm Water Management Model added the hydrological simulation function for LID structures in 2009. However, SWMM5.1 cannot consider the optimal or best physical specifications of LID design and planning fitted to a study area, nor can it instantly derive the best combination for multiple LID designs and plans. Therefore, in this study, a web-based decision support system (DSS for the EPA’s SWMM 5.1, referred to as the Water Management Analysis Module (WMAM is used to decide the most effective specifications of design and planning parameters for LID structure. This study was carried out over an urban catchment of University Technology Malaysia campus located in Johor, Malaysia. The hydrologic cycles with and without LID were simulated using EPA SWMM5.1. The sensitivity analysis and multiple scenario analysis were performed using WMAM. As a result, the effective specification of LID design parameters indicates that peak flow is reduced to 20.95% and 17.5% for two sub-catchments, S1 (highest by area and S6 (lowest by area by installing an LID structure. Thus, this study provides a tool for the best solution for what values for physical parameters will be the best for a specified LID type and what capacities can achieve the particular objectives using WMAM.

  4. Imaging, virtual planning, design, and production of patient-specific implants and clinical validation in craniomaxillofacial surgery.

    Science.gov (United States)

    Dérand, Per; Rännar, Lars-Erik; Hirsch, Jan-M

    2012-09-01

    The purpose of this article was to describe the workflow from imaging, via virtual design, to manufacturing of patient-specific titanium reconstruction plates, cutting guide and mesh, and its utility in connection with surgical treatment of acquired bone defects in the mandible using additive manufacturing by electron beam melting (EBM). Based on computed tomography scans, polygon skulls were created. Following that virtual treatment plans entailing free microvascular transfer of fibula flaps using patient-specific reconstruction plates, mesh, and cutting guides were designed. The design was based on the specification of a Compact UniLOCK 2.4 Large (Synthes(®), Switzerland). The obtained polygon plates were bent virtually round the reconstructed mandibles. Next, the resections of the mandibles were planned virtually. A cutting guide was outlined to facilitate resection, as well as plates and titanium mesh for insertion of bone or bone substitutes. Polygon plates and meshes were converted to stereolithography format and used in the software Magics for preparation of input files for the successive step, additive manufacturing. EBM was used to manufacture the customized implants in a biocompatible titanium grade, Ti6Al4V ELI. The implants and the cutting guide were cleaned and sterilized, then transferred to the operating theater, and applied during surgery. Commercially available software programs are sufficient in order to virtually plan for production of patient-specific implants. Furthermore, EBM-produced implants are fully usable under clinical conditions in reconstruction of acquired defects in the mandible. A good compliance between the treatment plan and the fit was demonstrated during operation. Within the constraints of this article, the authors describe a workflow for production of patient-specific implants, using EBM manufacturing. Titanium cutting guides, reconstruction plates for fixation of microvascular transfer of osteomyocutaneous bone grafts, and

  5. Human Factors Guidance for Control Room and Digital Human-System Interface Design and Modification, Guidelines for Planning, Specification, Design, Licensing, Implementation, Training, Operation and Maintenance

    Energy Technology Data Exchange (ETDEWEB)

    R. Fink, D. Hill, J. O' Hara

    2004-11-30

    Nuclear plant operators face a significant challenge designing and modifying control rooms. This report provides guidance on planning, designing, implementing and operating modernized control rooms and digital human-system interfaces.

  6. The Learning Design Specification

    NARCIS (Netherlands)

    Olivier, Bill; Tattersall, Colin

    2005-01-01

    Olivier, B. & Tattersall, C. (2005). The Learning Design Specification In: Koper, R. & Tattersall, C., Learning Design: A Handbook on Modelling and Delivering Networked Education and Training (pp. 21-40). Berlin-Heidelberg: Springer Verlag.

  7. The Learning Design Specification

    NARCIS (Netherlands)

    Olivier, Bill; Tattersall, Colin

    2005-01-01

    Olivier, B. & Tattersall, C. (2005). The Learning Design Specification In: Koper, R. & Tattersall, C., Learning Design: A Handbook on Modelling and Delivering Networked Education and Training (pp. 21-40). Berlin-Heidelberg: Springer Verlag.

  8. Specificities of sustainable tourism planning

    Directory of Open Access Journals (Sweden)

    Jegdić Vaso

    2013-01-01

    Full Text Available In the past two decades, companies have been mentioning achievement of sustainability in their activities as a target of companies, governments and non-profit organizations, although measuring the degree to which an organization conducts its activities in a sustainable manner, can be very difficult. Sustainable tourism development requires a process of planning and management that will unite the interests of various stakeholders in a sustainable and strategic way. It requires an understanding of the meaning of sustainable development and guiding values for promoting sustainable tourism. The paper points to the importance of cross-sector partnerships and the roles of different stakeholders in the planning of sustainable tourism projects. Special importance is given to the community of which a willingness to understand the impacts of tourism industry is expected, as well as various procedures of engagement in participatory planning, consensus building and conflict resolution among all stakeholders. The aim of this research is to find an optimal model of planning of sustainable tourism projects that would take into consideration the interests of all stakeholders and reflect the specificities imposed by the acceptance of the concept of sustainable development by all participants in the project.

  9. BUSINESS PLANS INFORMED BY DESIGN

    DEFF Research Database (Denmark)

    Petersen, Sørren Ingomar; Heebøll, John

    2011-01-01

    Today the value created by applying design at a business model and innovation level as opposed to a design and process level is marginal. Interviews with product developers from academia and industry suggest this is due to a lack of design perspective when formulating and evaluating business plans...... types. These were the design of products based on sustainable and on disruptive technologies. In conclusion, we recommend a procedure to align and translate business plan content into inspirational design briefs for enhancing design concept synthesis performance........ To remedy this, we propose including Design Quality Criteria drivers in the formulation of business plans. While auditing entrepreneurial business plans and design briefs content gaps were revealed between them. Strategy and context differences as well as a negative correlation between investors’ business...

  10. Planning as situated design

    DEFF Research Database (Denmark)

    Axel, Erik

    they have to decide who among us does what with what to achieve this. It will be argued that this process contains moral and political aspects, as well as aspects of privilege, and that these aspects as well as the organising of planning takes shape from concrete conditions. It will be argued that even...... into any conceivable detail of the house to be built, still, unanticipated conditions appear during the whole process which must be taken into account. The planning is therefore not a realization of an idea, but a political development in the material and practical existence of the house.......It is common to associate situated activity with concrete, craftlike or manual activity here and now and to reserve theoretical and abstract thinking for activities like theoretical experimentation and systematic planning. Much work has gone into demonstrating that these activities are concrete...

  11. Planning as situated design

    DEFF Research Database (Denmark)

    Axel, Erik

    It is common to associate situated activity with concrete, craftlike or manual activity here and now and to reserve theoretical and abstract thinking for activities like theoretical experimentation and systematic planning. Much work has gone into demonstrating that these activities are concrete...

  12. BUSINESS PLANS INFORMED BY DESIGN

    DEFF Research Database (Denmark)

    Petersen, Sørren Ingomar; Heebøll, John

    2011-01-01

    Today the value created by applying design at a business model and innovation level as opposed to a design and process level is marginal. Interviews with product developers from academia and industry suggest this is due to a lack of design perspective when formulating and evaluating business plans...

  13. Design Specification and Verification

    DEFF Research Database (Denmark)

    Staunstrup, Jørgen

    1997-01-01

    This is chapter 7 in an edited book that presents a number of issues of fundamental importance for the design of integrated hardware software products such as embedded, communication, and multimedia systems. This book is the result of a series of Ph.D. courses on hardware/software co-design held...

  14. Handbook factory planning and design

    CERN Document Server

    Wiendahl, Hans-Peter; Nyhuis, Peter

    2015-01-01

    This handbook introduces a methodical approach and pragmatic concept for the planning and design of changeable factories that act in strategic alliances to supply the ever-changing needs of the global market. In the first part, the change drivers of manufacturing enterprises and the resulting new challenges are considered in detail with focus on an appropriate change potential. The second part concerns the design of the production facilities and systems on the factory levels work place, section, building and site under functional, organisational, architectural and strategic aspects keeping in mind the environmental, health and safety aspects including corporate social responsibility. The third part is dedicated to the planning and design method that is based on a synergetic interaction of process and space. The accompanying project management of the planning and construction phase and the facility management for the effective utilization of the built premises close the book. -        Concise overview o...

  15. PLANNING DESIGN OFCOMPUTER REGION NETWORK

    Institute of Scientific and Technical Information of China (English)

    SongWei; GaoZhuang; GaoSong

    1996-01-01

    In this paper, authors describe the characters and the present situation of computer region network. Moreover, authors put forward the method to plan and design ration ally the computer regional network system depending on the actual situation, in order to share the resources of software and hardware resources of the network in best way and get higher efficiency of information management.

  16. Do more specific plans help you lose weight? Examining the relationship between plan specificity, weight loss goals, and plan content in the context of a weight management programme.

    Science.gov (United States)

    Dombrowski, Stephan U; Endevelt, Ronit; Steinberg, David M; Benyamini, Yael

    2016-11-01

    The conditions under which planning for behaviour change is most effective are not fully understood. In the context of a weight management programme, we examined the interrelationship between plan specificity, type of behaviour planned (diet vs. exercise), and weight loss goals. Prospective design and content analysis of plans formed by participants of a 10-week weight management programme. Participants (n = 239) formulated two plans, for dietary and exercise behaviours, respectively. Plans were rated for specificity by examining the number of plan components. Weight loss goals were assessed by asking how much weight participants intend to lose. Weight was measured objectively each of the 10 weeks. Changes in body mass index (BMI) over time and the interactions between plan specificity and weight loss goals, for all plans and separately for diet and exercise, were estimated using linear mixed models. Plan specificity was unrelated to weight loss, but interacted with weight loss goals in predicting linear change in BMI (t = -2.48): More specific plans were associated with higher decreases in weight in participants with high weight loss goals. Separate interaction tests for plans formulated for diet and exercise change showed that more specific dietary plans, but not exercise plans, were associated with higher decreases in weight in participants with high weight loss goals (t = -2.21). Within a population that is highly motivated to lose weight, the combination of high weight loss goals and formulating detailed plans for changing dietary behaviours may be most effective in supporting weight loss. Statement of contribution What is already known on this subject? More specific plans are associated with increased performance of health-related behaviours. More motivated individuals form more specific plans. The interrelationship between plan specificity, plan content and behaviour-related goals in relation intervention effectiveness has not been explored to date

  17. The utility of 3D printing for surgical planning and patient-specific implant design for complex spinal pathologies: case report.

    Science.gov (United States)

    Mobbs, Ralph J; Coughlan, Marc; Thompson, Robert; Sutterlin, Chester E; Phan, Kevin

    2017-04-01

    OBJECTIVE There has been a recent renewed interest in the use and potential applications of 3D printing in the assistance of surgical planning and the development of personalized prostheses. There have been few reports on the use of 3D printing for implants designed to be used in complex spinal surgery. METHODS The authors report 2 cases in which 3D printing was used for surgical planning as a preoperative mold, and for a custom-designed titanium prosthesis: one patient with a C-1/C-2 chordoma who underwent tumor resection and vertebral reconstruction, and another patient with a custom-designed titanium anterior fusion cage for an unusual congenital spinal deformity. RESULTS In both presented cases, the custom-designed and custom-built implants were easily slotted into position, which facilitated the surgery and shortened the procedure time, avoiding further complex reconstruction such as harvesting rib or fibular grafts and fashioning these grafts intraoperatively to fit the defect. Radiological follow-up for both cases demonstrated successful fusion at 9 and 12 months, respectively. CONCLUSIONS These cases demonstrate the feasibility of the use of 3D modeling and printing to develop personalized prostheses and can ease the difficulty of complex spinal surgery. Possible future directions of research include the combination of 3D-printed implants and biologics, as well as the development of bioceramic composites and custom implants for load-bearing purposes.

  18. Evolving treatment plan quality criteria from institution-specific experience.

    Science.gov (United States)

    Ruan, D; Shao, W; Demarco, J; Tenn, S; King, C; Low, D; Kupelian, P; Steinberg, M

    2012-05-01

    The dosimetric aspects of radiation therapy treatment plan quality are usually evaluated and reported with dose volume histogram (DVH) endpoints. For clinical practicality, a small number of representative quantities derived from the DVH are often used as dose endpoints to summarize the plan quality. National guidelines on reference values for such quantities for some standard treatment approaches are often used as acceptance criteria to trigger treatment plan review. On the other hand, treatment prescription and planning approaches specific to each institution warrants the need to report plan quality in terms of practice consistency and with respect to institution-specific experience. The purpose of this study is to investigate and develop a systematic approach to record and characterize the institution-specific plan experience and use such information to guide the design of plan quality criteria. In the clinical setting, this approach will assist in (1) improving overall plan quality and consistency and (2) detecting abnormal plan behavior for retrospective analysis. The authors propose a self-evolving methodology and have developed an in-house prototype software suite that (1) extracts the dose endpoints from a treatment plan and evaluates them against both national standard and institution-specific criteria and (2) evolves the statistics for the dose endpoints and updates institution-specific criteria. The validity of the proposed methodology was demonstrated with a database of prostate stereotactic body radiotherapy cases. As more data sets are accumulated, the evolving institution-specific criteria can serve as a reliable and stable consistency measure for plan quality and reveals the potential use of the "tighter" criteria than national standards or projected criteria, leading to practice that may push to shrink the gap between plans deemed acceptable and the underlying unknown optimality. The authors have developed a rationale to improve plan quality and

  19. Lesson Plan Design for Facilitating Differentiated Instruction

    Science.gov (United States)

    Baker, Pamela Hudson; Fleming, Louise Conn

    2005-01-01

    This study examines the role of lesson plan design in helping teacher candidates to meet diverse learning needs. The authors studied student teachers who had been taught to use a differential lesson plan to see if they were differentiating in their planning, assessment, and instruction. They concluded that, indeed, lesson plan design does…

  20. 1994 INEL site-specific plan

    Energy Technology Data Exchange (ETDEWEB)

    Couch, B.

    1994-05-01

    This report presents plans for environmental restoration and waste management activities at the Idaho National Engineering Laboratory for fiscal year 1994. This years`s plan focuses on issues affecting the Environmental Restoration and Waste Management Programs. The Environmental Restoration Program is concerned with all aspects of assessment and cleanup of inactive operations. It involves assessing and cleaning up (where necessary) inactive INEL waste areas that could release harmful substances into the environment, as well as safely managing surplus nuclear facilities. The Waste Management program involves treatment, storage, and disposal of radioactive, hazardous, mixed, and industrial waste by DOE activities. This program is designed to protect the safety of INEL employees, the public, and the environment in the design, construction, maintenance, and operation of INEL treatment, storage, and disposal facilities. It operates facilities in a cost-effective, environmentally sound, regulatory compliant, and publicly acceptable manner.

  1. 1994 INEL site-specific plan

    Energy Technology Data Exchange (ETDEWEB)

    Couch, B.

    1994-05-01

    This report presents plans for environmental restoration and waste management activities at the Idaho National Engineering Laboratory for fiscal year 1994. This years`s plan focuses on issues affecting the Environmental Restoration and Waste Management Programs. The Environmental Restoration Program is concerned with all aspects of assessment and cleanup of inactive operations. It involves assessing and cleaning up (where necessary) inactive INEL waste areas that could release harmful substances into the environment, as well as safely managing surplus nuclear facilities. The Waste Management program involves treatment, storage, and disposal of radioactive, hazardous, mixed, and industrial waste by DOE activities. This program is designed to protect the safety of INEL employees, the public, and the environment in the design, construction, maintenance, and operation of INEL treatment, storage, and disposal facilities. It operates facilities in a cost-effective, environmentally sound, regulatory compliant, and publicly acceptable manner.

  2. Experimental Plans and Intensive Numerical Aided Design

    Directory of Open Access Journals (Sweden)

    Yvon Gardan

    2014-09-01

    Full Text Available This paper deals with new methods to optimize design and subsequent phases, notably in SMEs specialized in manufacturing. SMEs use numerical simulation to verify that the design meets the expectations of the specification, following the current traditional process: CAD model, simulation of its behavior, changes in the CAD model... This process suffers from a number of drawbacks: no overall multi-criteria vision, use of CAD software, by nature "constructive, not considering the overall objectives (even with integration of the parameters or with considering the downstream phases. The research centre DINCCS led several projects, relying on industrial cases to consider more efficient approaches. It is proposed to reverse this process by making intensive simulations, based on trade knowledge, before design itself. In order to plan the great number of simulations, automatically designed plan of experiences are used. We discuss the application of this approach to intensive simulations. The stakes are crucial for SMEs, particularly manufacturing ones. Using numerical simulation (optimization intensively, before setting the CAD model, they can get unexpected gains (mass, better use of the means of manufacture.... The results show that the proposed approach is a very promising new way of computer aided design..

  3. Audel carpenter's and builder's math, plans, and specifications

    CERN Document Server

    Miller, Mark Richard

    2005-01-01

    You can count on a good planA successful building or remodeling job requires not only a plan, but also the skill to interpret it and an understanding of the mathematics behind it. Whether you are a builder by trade or a do-it-yourself carpenter by choice, turn to this newly updated guide for easy explanations of the math involved and clear instructions on developing and using the necessary plans and specifications.* Explore the different types of wood products and learn what is best for your purpose* Choose appropriate building materials for weather and other natural factors* Refresh your knowledge of fractions, ratios, geometry, and measurement* Understand how to use basic surveying tools* Become familiar with the design process and recognize various styles of architecture* Learn to read architectural drawings and work with computer design

  4. Of Mechanism Design and Multiagent Planning

    NARCIS (Netherlands)

    Van der Krogt, R.P.J.; De Weerdt, M.M.; Zhang, Y.

    2008-01-01

    Multiagent planning methods are concerned with planning by and for a group of agents. If the agents are selfinterested, they may be tempted to lie in order to obtain an outcome that is more rewarding for them. We therefore study the multiagent planning problem from a mechanism design perspective,

  5. Water NSTF Design, Instrumentation, and Test Planning

    Energy Technology Data Exchange (ETDEWEB)

    Lisowski, Darius D.; Gerardi, Craig D.; Hu, Rui; Kilsdonk, Dennis J.; Bremer, Nathan C.; Lomperski, Stephen W.; Kraus, Adam R.; Bucknor, Matthew D.; Lv, Qiuping; Farmer, Mitchell T.

    2017-08-01

    The following report serves as a formal introduction to the water-based Natural convection Shutdown heat removal Test Facility (NSTF) program at Argonne. Since 2005, this US Department of Energy (DOE) sponsored program has conducted large scale experimental testing to generate high-quality and traceable validation data for guiding design decisions of the Reactor Cavity Cooling System (RCCS) concept for advanced reactor designs. The most recent facility iteration, and focus of this report, is the operation of a 1/2 scale model of a water-RCCS concept. Several features of the NSTF prototype align with the conceptual design that has been publicly released for the AREVA 625 MWt SC-HTGR. The design of the NSTF also retains all aspects common to a fundamental boiling water thermosiphon, and thus is well poised to provide necessary experimental data to advance basic understanding of natural circulation phenomena and contribute to computer code validation. Overall, the NSTF program operates to support the DOE vision of aiding US vendors in design choices of future reactor concepts, advancing the maturity of codes for licensing, and ultimately developing safe and reliable reactor technologies. In this report, the top-level program objectives, testing requirements, and unique considerations for the water cooled test assembly are discussed, and presented in sufficient depth to support defining the program’s overall scope and purpose. A discussion of the proposed 6-year testing program is then introduced, which outlines the specific strategy and testing plan for facility operations. The proposed testing plan has been developed to meet the toplevel objective of conducting high-quality test operations that span across a broad range of single- and two-phase operating conditions. Details of characterization, baseline test cases, accident scenario, and parametric variations are provided, including discussions of later-stage test cases that examine the influence of geometric

  6. Business System Planning Project System Requirements Specification

    Energy Technology Data Exchange (ETDEWEB)

    NELSON, R.E.

    2000-09-08

    The purpose of the Business Systems Planning Project System Requirements Specification (SRS) is to provide the outline and contents of the requirements for the CH2M HILL Hanford Group, Inc. (CHG) integrated business and technical information systems. The SRS will translate proposed objectives into the statement of the functions that are to be performed and data and information flows that they require. The requirements gathering methodology will use (1) facilitated group requirement sessions; (2) individual interviews; (3) surveys; and (4) document reviews. The requirements will be verified and validated through coordination of the technical requirement team and CHG Managers. The SRS document used the content and format specified in Lockheed Martin Services, Inc. Organization Standard Software Practices in conjunction with the Institute of Electrical and Electronics Engineers Standard 8340-1984 for Systems Requirements Documents.

  7. Planning and design of information systems

    CERN Document Server

    Blokdijk, André

    1991-01-01

    Planning and Design of Information Systems provides a theoretical base and a practical method of executing the planning of computerized information systems, and the planning and design of individual applications. The book is organized into five parts, covering the non-technical and nonimplementational part of information systems planning, design, and development. Part I gives the theoretical base for the subsequent parts of the book. It discusses modeling, techniques, notations, boundaries, quality issues and aspects, and decomposition techniques and problems. Part II discusses the needs, prob

  8. 23 CFR 650.207 - Plans, specifications and estimates.

    Science.gov (United States)

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Plans, specifications and estimates. 650.207 Section 650... § 650.207 Plans, specifications and estimates. (a) Emphasis shall be placed on erosion control in the preparation of plans, specifications and estimates. (b) All reasonable steps shall be taken to insure...

  9. Planning and Designing Safe Facilities

    Science.gov (United States)

    Seidler, Todd

    2006-01-01

    Those who manage physical education, athletic, and recreation programs have a number of legal duties that they are expected to carry out. Among these are an obligation to take reasonable precautions to ensure safe programs and facilities for all participants, spectators, and staff. Physical education and sports facilities that are poorly planned,…

  10. Designing a marketing plan that works.

    Science.gov (United States)

    Dienemann, J A; Wintz, L

    1992-01-01

    As healthcare organizations incorporate marketing strategies into daily operations, nurse executives find themselves involved in the process with varying degrees of comfort and success. The authors discuss the nurse executive's role and responsibilities for the success of a marketing plan and describe the importance of recognizing how far marketing has evolved within an organization in order to design a suitable plan successfully.

  11. Specifications in early conceptual design work

    DEFF Research Database (Denmark)

    Hansen, Claus Thorp; Andreasen, Mogens Myrup

    2007-01-01

    specifications, which express attractive product goals, and has to synthesise the product idea. The authors of this paper see a challenge to enhance and improve our understanding of the nature of design specifications as a means to support the synthesis of a product idea. In this empirical study we analyse...... the structure and content of design specifications during early ideation activities, where initial design specifications are formulated and a product idea is synthesised. We have analysed specification documents of 19 teams of novice designers. Our analysis indicates that a productive product design...... specification in early conceptual design consists of few specification statements, which express value, important aspects of product context and articulate key functions. A product design specification, which contains a lot of specification statements about product properties, is not productive to support...

  12. Telecommunications network modelling, planning and design

    CERN Document Server

    Evans, Sharon

    2003-01-01

    Telecommunication Network Modelling, Planning and Design addresses sophisticated modelling techniques from the perspective of the communications industry and covers some of the major issues facing telecommunications network engineers and managers today. Topics covered include network planning for transmission systems, modelling of SDH transport network structures and telecommunications network design and performance modelling, as well as network costs and ROI modelling and QoS in 3G networks.

  13. Smile design--specific considerations.

    Science.gov (United States)

    Morley, J

    1997-09-01

    Smile design is a new discipline that has come to the forefront with the recent popularity of cosmetic dentistry techniques. This article explores some of the principles used in smile design that can enhance the esthetics of any anterior restorative procedure.

  14. Design: The Future of Planning?

    Science.gov (United States)

    2009-05-04

    AVAILABILITY STATEMENT For Example : Distribution statement A: Approved for public release; Distribution is unlimited. 13. SUPPLEMENTARY NOTES A paper...that GST is viewed as a pseudoscience by some The basis of Vego’ s analysis is two simplistic non-peer reviewed critiques of GST.xxvi SOD Failures...not present any examples that detailed cases of successful design application or theoretical cases that speculated how design could be used

  15. Specifications in early conceptual design work

    DEFF Research Database (Denmark)

    Hansen, Claus Thorp; Andreasen, Mogens Myrup

    2007-01-01

    In early conceptual design the design team is working in an uncertain situation, where the understanding of a need is limited and not much is known about the solution space. In this situation the design team has to both analyse need and explore solution space. Thus, the team has to formulate design...... specification in early conceptual design consists of few specification statements, which express value, important aspects of product context and articulate key functions. A product design specification, which contains a lot of specification statements about product properties, is not productive to support...

  16. Optical network design and planning

    CERN Document Server

    Simmons, Jane M

    2014-01-01

    This book takes a pragmatic approach to designing state-of-the-art optical networks for backbone, regional, and metro-core networks.   Algorithms and methodologies related to routing, regeneration, wavelength assignment, subrate-traffic grooming, and protection are presented, with an emphasis on optical-bypass-enabled (or all-optical) networks. There are numerous case studies throughout the text to illustrate the concepts, using realistic networks and traffic sets. A full chapter of economic studies offers guidelines as to when and how optical-bypass technology should be deployed. There is also extensive coverage of recent research to provide insight into how optical networks are likely to evolve. The second edition includes new chapters on dynamic optical networking and flexible/elastic optical networks. There is expanded coverage of new physical-layer technology and its impact on network design, along with enhanced coverage of ROADM architectures, including the colorless, directionless, contentionless, a...

  17. Messy Design: Organic Planning for Blended Learning

    Science.gov (United States)

    Rankin, Andrea; Luzeckyj, Ann; Haggis, Jane; Gare, Callum

    2016-01-01

    In this paper we argue that a messy design process does not mitigate against sharing and transfer of artefacts across educational domains. In fact, such a process can aid in developing a model for learning and teaching that is reusable and authentic. We describe the planning and design of an integrated and interactive blended learning environment…

  18. ITER LHCD plans and design

    Energy Technology Data Exchange (ETDEWEB)

    Bibet, Ph.; Beaumont, B.; Delpech, L.; Ekedahl, A.; Kazarian, F.; Litaudon, X.; Prou, M. [CEA Cadarache, Dept. de Recherches sur la Fusion Controlee (DRFC), 13 - Saint-Paul-lez-Durance (France); Belo, J.H.; Bizarro, J.P.S. [Centro de Fusao Nuclear, Associacao Euratom-IST, Instituto Superior Tecnico, Lisboa (Portugal); Granucci, G. [Associazione EURATOM-ENEA sulla Fusione, Milano (Italy); Kuzikov, S. [Institute of Applied Physics, Nizhny Novgorod (Russian Federation); Mailloux, J. [Euratom/UKAEA Fusion Association, Culham Science Centre, Abingdon (United Kingdom); Mirizzi, F.; Pericoli, V.; Tuccillo, A.A. [Association Euratom-ENEA sulla Fusione, Centro Ricerche Energia Frascati (Italy); Rantamaki, K. [Association Euratom-Tekes, VTT (Finland)

    2005-07-01

    LH waves experimentally exhibit the highest Current Drive efficiency at low plasma temperature, therefore they are the most suitable candidates for controlling the current profile in the off axis part of ITER Steady State plasmas. For this purpose, a 5 GHz, 20 MW CW LH system has been designed, that relies on a generator made of 24 klystrons, 1 MW each, 60 metres long circular oversized transmission lines, one antenna, based on the Passive Active Multi-function (PAM) concept. High reliability of the launcher is achieved, by limiting the power density to 33 MW/m{sup 2}. Together with the overall system description, the present results achieved toward ITER are presented. The different ongoing project are listed. The remaining outstanding problems are depicted. (authors)

  19. Interior design. Mastering the master plan.

    Science.gov (United States)

    Mesbah, C E

    1995-10-01

    Reflecting on the results of the survey, this proposed interior design master planning process addresses the concerns and issues of both CEOs and facility managers in ways that focus on problem-solving strategies and methods. Use of the interior design master plan process further promotes the goals and outcomes expressed in the survey by both groups. These include enhanced facility image, the efficient selection of finishes and furnishings, continuity despite staff changes, and overall savings in both costs and time. The interior design master plan allows administrators and facility managers to anticipate changes resulting from the restructuring of health care delivery. The administrators and facility managers are then able to respond in ways that manage those changes in the flexible and cost-effective manner they are striving for. This framework permits staff members to concentrate their time and energy on the care of their patients--which is, after all, what it's all about.

  20. Towards a theory of product design specifications

    DEFF Research Database (Denmark)

    Hansen, Claus Thorp; Andreasen, Mogens Myrup

    2004-01-01

    The product design specification is an important element in a product development project because it defines the target to be met. One requirement on the product design specification is to articulate and communicate the aspects, which makes the product attractive seen from the users' viewpoint....... In the design methodology literature we find guidelines and methods to compile a product design specification. The contributions are based on the common underlying assumption that it is meaningful and the only feasible approach to interpret the result of a need analysis into a set of technical specifications......, which express the customers¿ need and perception of value. In this paper we will scrutinize this assumption. We outline the roles and tasks of the product design specification in order to identify the requirements on a theory of product design specifications and we identify existing theory elements...

  1. Co-evolutions of planning and design: Risks and benefits of design perspectives in planning systems

    NARCIS (Netherlands)

    Assche, van K.A.M.; Beunen, R.; Duineveld, M.; Jong, de H.C.

    2013-01-01

    We develop an evolutionary perspective on spatial planning to investigate the potential contributions of design approaches to the coordination of spatial organization. After a rearticulation of the concepts of planning and design in this perspective, we distinguish six essential features of the

  2. Embedded systems specification and design languages

    CERN Document Server

    Villar, Eugenio

    2008-01-01

    This book is the latest contribution to the Chip Design Languages series and it consists of selected papers presented at the Forum on Specifications and Design Languages (FDL'07), in September 2007. The book represents the state-of-the-art in research and practice, and it identifies new research directions. It highlights the role of specification and modelling languages, and presents practical experiences with specification and modelling languages.

  3. Project W-314 specific test and evaluation plan for 241-AY-01A pump pit upgrade

    Energy Technology Data Exchange (ETDEWEB)

    Hays, W.H.

    1998-05-19

    This Specific Test and Evaluation Plan (STEP) defines the test and evaluation activities encompassing the upgrade of the 241-AY-0IA Pump Pit for the W-314 Project. The purpose of this Specific Test and Evaluation Plan (STEP) is to provide a detailed written plan for the systematic testing of modifications made to the 241-AY-01A Pump Pit by the W-314 Project. The STEP develops the outline for test procedures that verify the system`s performance to the established Project design criteria. The STEP is a lower tier document based on the W-314 Test and Evaluation Plan (TEP).

  4. Project W-314 specific test and evaluation plan for 241-AY-02A pump pit upgrade

    Energy Technology Data Exchange (ETDEWEB)

    Hays, W.H.

    1998-05-19

    This Specific Test and Evaluation Plan (STEP) defines the test and evaluation activities encompassing the upgrade of the 241-AY-02A Pump Pit for the W-314 Project. The purpose of this Specific Test and Evaluation Plan (STEP) is to provide a detailed written plan for the systematic testing of modifications made to the 241-AY-02A Pump Pit by the W-314 Project. The STEP develops the outline for test procedures that verify the system`s performance to the established Project design criteria. The STEP is a lower tier document based on the W-314 Test and Evaluation Plan (TEP).

  5. A Guide to Food Service Operation Planning with Information on Preparing and Submitting Plans and Specifications.

    Science.gov (United States)

    Ohio State Dept. of Health, Columbus.

    Guidelines are presented for planning a food service operation which is defined as any place kept or maintained for the purpose of preparing or serving meals or lunches for a consideration. Brief discussions are presented pertaining to the value of planning and the preparation and use of plans and specifications. Recommendations and specifications…

  6. Conceptual Design Plan SM-43 Replacement Project

    Energy Technology Data Exchange (ETDEWEB)

    University of California, Los Alamos National Laboratory, SCC Project Office

    2000-11-01

    The Los Alamos National Laboratory Conceptual Design Plan for the SM-43 Replacement Project outlines plans for replacing the SM-43 Administration Building. Topics include the reasons that replacement is considered a necessity; the roles of the various project sponsors; and descriptions of the proposed site and facilities. Also covered in this proposal is preliminary information on the project schedule, cost estimates, acquisition strategy, risk assessment, NEPA strategy, safety strategy, and safeguards and security. Spreadsheets provide further detail on space requirements, project schedules, and cost estimates.

  7. Design in the planning arena : how regional designing influences strategic spatial planning

    NARCIS (Netherlands)

    Kempenaar, Annet

    2017-01-01

    Regional designing is a form of spatial design that engages with the future physical form and arrangement of regions, including its aesthetic appearances and how it can come about. As such it is closely entangled with spatial planning. This thesis studies the influence of regional designing on

  8. Planning to Serve: Using Backwards Planning to Design Service-Learning Lesson Plans in the Preservice Curriculum

    Science.gov (United States)

    Stiler, Gary

    2009-01-01

    The author describes how the Understanding by Design (backwards planning) lesson plan format was used by his preservice K-12 students to develop service-learning lesson plans. Preservice teachers in a multicultural education course were given an assignment to develop service-learning lesson plans using the Understanding by Design planning process.…

  9. Engineered waste-package-system design specification

    Energy Technology Data Exchange (ETDEWEB)

    1983-05-01

    This report documents the waste package performance requirements and geologic and waste form data bases used in developing the conceptual designs for waste packages for salt, tuff, and basalt geologies. The data base reflects the latest geotechnical information on the geologic media of interest. The parameters or characteristics specified primarily cover spent fuel, defense high-level waste, and commercial high-level waste forms. The specification documents the direction taken during the conceptual design activity. A separate design specification will be developed prior to the start of the preliminary design activity.

  10. Interior Design's Role in Educational Specifications.

    Science.gov (United States)

    Keller, Mary Ann

    1986-01-01

    An experienced interior designer, equipped with a well-written educational specification, will specify the best materials and coordinate colors, materials, and furnishings in line with the district's budget. (MLF)

  11. Integrated Energy Design in Master Planning

    DEFF Research Database (Denmark)

    Strømann-Andersen, Jakob Bjørn

    of opportunities and limitations with regard to light, shade, sun and wind. The aim is threefold: (1) to unfold the link between building energy use and urban density, typology and fabric; (2) to analyse how technical scientific knowledge can be integrated in early urban planning and design decisions (IED); and (3...... in character as daylight is taken into account. Furthermore the results suggest that there are limits to urban densification (200-300%) as an energy optimization strategy. The solar energy and daylight potential should be considered, and indeed protected, as a common resource in urban design. The most...

  12. Patient-specific hip prostheses designed by surgeons

    Directory of Open Access Journals (Sweden)

    Coigny Florian

    2016-09-01

    Full Text Available Patient-specific bone and joint replacement implants lead to better functional and aesthetic results than conventional methods [1], [2], [3]. But extracting 3D shape information from CT Data and designing individual implants is demanding and requires multiple surgeon-to-engineer interactions. For manufacturing purposes, Additive Manufacturing offers various advantages, especially for low volume manufacturing parts, such as patient specific implants. To ease these new approaches and to avoid surgeon-to-engineer interactions a new design software approach is needed which offers highly automated and user friendly planning steps.

  13. Station planning and design incorporating modern power system practice

    CERN Document Server

    Martin, PC

    1991-01-01

    The planning and design of new power stations can involve complex interaction between the many engineering disciplines involved as well as environmental, planning, economical, political and social pressures. This volume aims to provide a logical review of the procedures involved in power station development. The engineering aspects are outlined in detail, with examples, showing the basis of the relationships involved together with ""non-engineering"" factors so that the engineer can draw on the information provided for specific projects. The civil engineering and building of power stations are

  14. URPD: a specific product primer design tool.

    Science.gov (United States)

    Chuang, Li-Yeh; Cheng, Yu-Huei; Yang, Cheng-Hong

    2012-06-19

    Polymerase chain reaction (PCR) plays an important role in molecular biology. Primer design fundamentally determines its results. Here, we present a currently available software that is not located in analyzing large sequence but used for a rather straight-forward way of visualizing the primer design process for infrequent users. URPD (yoUR Primer Design), a web-based specific product primer design tool, combines the NCBI Reference Sequences (RefSeq), UCSC In-Silico PCR, memetic algorithm (MA) and genetic algorithm (GA) primer design methods to obtain specific primer sets. A friendly user interface is accomplished by built-in parameter settings. The incorporated smooth pipeline operations effectively guide both occasional and advanced users. URPD contains an automated process, which produces feasible primer pairs that satisfy the specific needs of the experimental design with practical PCR amplifications. Visual virtual gel electrophoresis and in silico PCR provide a simulated PCR environment. The comparison of Practical gel electrophoresis comparison to virtual gel electrophoresis facilitates and verifies the PCR experiment. Wet-laboratory validation proved that the system provides feasible primers. URPD is a user-friendly tool that provides specific primer design results. The pipeline design path makes it easy to operate for beginners. URPD also provides a high throughput primer design function. Moreover, the advanced parameter settings assist sophisticated researchers in performing experiential PCR. Several novel functions, such as a nucleotide accession number template sequence input, local and global specificity estimation, primer pair redesign, user-interactive sequence scale selection, and virtual and practical PCR gel electrophoresis discrepancies have been developed and integrated into URPD. The URPD program is implemented in JAVA and freely available at http://bio.kuas.edu.tw/urpd/.

  15. 75 FR 54031 - Approval and Promulgation of Implementation Plans; Designation of Areas for Air Quality Planning...

    Science.gov (United States)

    2010-09-03

    ...; Designation of Areas for Air Quality Planning Purposes; State of California; PM-10; Redesignation of the Coso Junction Planning Area to Attainment; Approval of PM-10 Maintenance Plan for the Coso Junction Planning... State of California's request to redesignate the Coso Junction planning area (CJPA) to attainment for...

  16. From Design Specification to SystemC

    Directory of Open Access Journals (Sweden)

    Rachid Boudour

    2006-01-01

    Full Text Available In this paper, we present a framework for transforming the design model into SystemC code. Such a framework uses as input UML state machine and object diagrams, which are more and more used as design models in embedded systems. To do this, we have firstly used Poseidon tool for editing the design model and generating the XMI representation, and secondly integrated a transformation module leading to SystemC code. The mapping to SystemC code offers not only a system-level executable specification, but also a means to facilitating the system partitioning in hardware and software parts.

  17. Forum on Specifications and Design Languages 2012

    CERN Document Server

    2014-01-01

    This book brings together a selection of the best papers from the fifteenth edition of the Forum on specification and Design Languages Conference (FDL), which was held in September 2012 at Vienna University of Technology, Vienna, Austria.  FDL is a well-established international forum devoted to dissemination of research results, practical experiences and new ideas in the application of specification, design and verification languages to the design, modeling and verification of integrated circuits, complex hardware/software embedded systems, and mixed-technology systems.  ·         Covers Assertion Based Design, Verification & Debug; ·         Includes language-based modeling and design techniques for embedded systems; ·         Covers design, modeling and verification of mixed physical domain and mixed signal systems that include significant analog parts in electrical and non-electrical domains; ·         Includes formal and semi-formal system level design methods fo...

  18. Designing specificity of protein-substrate interactions

    NARCIS (Netherlands)

    Coluzza, I.; Frenkel, D.

    2004-01-01

    One of the key properties of biological molecules is that they can bind strongly to certain substrates yet interact only weakly with the very large number of other molecules that they encounter. Using a simple lattice model, we test several methods to design molecule-substrate binding specificity. W

  19. Designing specificity of protein-substrate interactions

    NARCIS (Netherlands)

    Coluzza, I.; Frenkel, D.

    2004-01-01

    One of the key properties of biological molecules is that they can bind strongly to certain substrates yet interact only weakly with the very large number of other molecules that they encounter. Using a simple lattice model, we test several methods to design molecule-substrate binding specificity.

  20. Computational network design from functional specifications

    KAUST Repository

    Peng, Chi Han

    2016-07-11

    Connectivity and layout of underlying networks largely determine agent behavior and usage in many environments. For example, transportation networks determine the flow of traffic in a neighborhood, whereas building floorplans determine the flow of people in a workspace. Designing such networks from scratch is challenging as even local network changes can have large global effects. We investigate how to computationally create networks starting from only high-level functional specifications. Such specifications can be in the form of network density, travel time versus network length, traffic type, destination location, etc. We propose an integer programming-based approach that guarantees that the resultant networks are valid by fulfilling all the specified hard constraints and that they score favorably in terms of the objective function. We evaluate our algorithm in two different design settings, street layout and floorplans to demonstrate that diverse networks can emerge purely from high-level functional specifications.

  1. Designing Nonwovens to Meet Pore Size Specifications

    Directory of Open Access Journals (Sweden)

    Glen E. Simmonds

    2007-04-01

    Full Text Available New nonwovens applications in areas such as filtration require a media designed to particular pore size specifications in the 3 to 20 micron range. The purpose of this work was to develop a basis by which to design and construct a fabric with given pore size specifications. While doing so we have provided a validation for two different mathematical models. We have also found that bicomponent spunbonded islands-in-the-sea nonwoven fabrics can be designed very precisely to achieve target pore diameters and porosity. Mathematical models can be used to develop fabric specifications in the standard manufacturing terms of basis weight and fiber diameter. Measured mean flow pore diameters for the test fabrics showed excellent correlation to targeted mean flow pore diameters for both models. The experimental fit to the Bryner model is the better of the two, but requires specification of fabric thickness in addition to basis weight and fiber diameter to achieve actual mean pore diameters that closely match target values. Experimental validation of the influence of fabric thickness on the mean flow pore diameter at constant basis weight and fiber diameter remains open for further investigation. In addition, achieving complete separation of the island and sea polymers along with unbundling of the island fibers remain areas for improvement.

  2. 36 CFR 910.11 - Comprehensive urban planning and design.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Comprehensive urban planning... CORPORATION GENERAL GUIDELINES AND UNIFORM STANDARDS FOR URBAN PLANNING AND DESIGN OF DEVELOPMENT WITHIN THE PENNSYLVANIA AVENUE DEVELOPMENT AREA Urban Planning and Design Concerns § 910.11 Comprehensive urban...

  3. Physical Planning in Place-Making through Design and Image Building

    OpenAIRE

    2013-01-01

    This paper discusses how physical planning works with place-making through urban design to support image creation in a municipality that aims to create a new image for its city. Two large-scale urban development projects in Sweden are analysed. The analysis focuses on official plans and documentation, and expert interviews. It distinguishes how place-making by physical planning happens through aestheticisation, the design of physical environments for specific groups of inhabitants, and by gra...

  4. Plan and Design Meticulously and Promoting Technical Progress

    Institute of Scientific and Technical Information of China (English)

    Miao Chengwu

    1994-01-01

    @@ Plan and design is the key link in captial construction, and the soul of engineering construction. China Petroleum Planning & Engineering Institute (CPPEI) is one of the main undertakers for planning and designing of petroleum industry,the only leading multi-functional institute with the first class design certificate. Now it has been an organization under the China National Petroleum Corporation(CNPC)for making development strategy planning, project evaluations and technical consulting, drawing up project development plan and providing technical recommendations. It can complete plan and design for the oil and gas field facilities, pipeline construction,petroleum relinery and petro-chemical industry engineering at home and abroad. It is also a center of servicing for new technical development and scientific research. Since CPPEI was established in 1978,it has meticulously conducted on planning and designing for the technical progress of petroleum engineering.

  5. Food Design Thinking: A Branch of Design Thinking Specific to Food Design

    Science.gov (United States)

    Zampollo, Francesca; Peacock, Matthew

    2016-01-01

    Is there a need for a set of methods within Design Thinking tailored specifically for the Food Design process? Is there a need for a branch of Design Thinking dedicated to Food Design alone? Chefs are not generally trained in Design or Design Thinking, and we are only just beginning to understand how they ideate and what recourses are available to…

  6. Food Design Thinking: A Branch of Design Thinking Specific to Food Design

    Science.gov (United States)

    Zampollo, Francesca; Peacock, Matthew

    2016-01-01

    Is there a need for a set of methods within Design Thinking tailored specifically for the Food Design process? Is there a need for a branch of Design Thinking dedicated to Food Design alone? Chefs are not generally trained in Design or Design Thinking, and we are only just beginning to understand how they ideate and what recourses are available to…

  7. 7 CFR 1724.53 - Preparation of plans and specifications.

    Science.gov (United States)

    2010-01-01

    ..., including a one-line diagram, plot and foundation plan, grounding plan, and plans and elevations of..., including: (A) A plot plan showing the location of the proposed building plus paving and site...

  8. Salt bridges: geometrically specific, designable interactions.

    Science.gov (United States)

    Donald, Jason E; Kulp, Daniel W; DeGrado, William F

    2011-03-01

    Salt bridges occur frequently in proteins, providing conformational specificity and contributing to molecular recognition and catalysis. We present a comprehensive analysis of these interactions in protein structures by surveying a large database of protein structures. Salt bridges between Asp or Glu and His, Arg, or Lys display extremely well-defined geometric preferences. Several previously observed preferences are confirmed, and others that were previously unrecognized are discovered. Salt bridges are explored for their preferences for different separations in sequence and in space, geometric preferences within proteins and at protein-protein interfaces, co-operativity in networked salt bridges, inclusion within metal-binding sites, preference for acidic electrons, apparent conformational side chain entropy reduction on formation, and degree of burial. Salt bridges occur far more frequently between residues at close than distant sequence separations, but, at close distances, there remain strong preferences for salt bridges at specific separations. Specific types of complex salt bridges, involving three or more members, are also discovered. As we observe a strong relationship between the propensity to form a salt bridge and the placement of salt-bridging residues in protein sequences, we discuss the role that salt bridges might play in kinetically influencing protein folding and thermodynamically stabilizing the native conformation. We also develop a quantitative method to select appropriate crystal structure resolution and B-factor cutoffs. Detailed knowledge of these geometric and sequence dependences should aid de novo design and prediction algorithms.

  9. On the Asymptotic Relative Efficiency of Planned Missingness Designs

    NARCIS (Netherlands)

    Rhemtulla, M.; Savalei, V.; Little, T.D.

    2016-01-01

    In planned missingness (PM) designs, certain data are set a priori to be missing. PM designs can increase validity and reduce cost; however, little is known about the loss of efficiency that accompanies these designs. The present paper compares PM designs to reduced sample (RN) designs that have the

  10. 48 CFR 252.211-7002 - Availability for examination of specifications, standards, plans, drawings, data item...

    Science.gov (United States)

    2010-10-01

    ... examination of specifications, standards, plans, drawings, data item descriptions, and other pertinent... of Provisions And Clauses 252.211-7002 Availability for examination of specifications, standards... the following provision: Availability for Examination of Specifications, Standards, Plans,...

  11. Regional Design in Dutch Transport Planning Strategies

    NARCIS (Netherlands)

    Balz, V.E.; Stead, D.

    2014-01-01

    The last decade has witnessed various trends in decentralization of government responsibilities related to spatial planning in the Netherlands and this has resulted in a differing flexibility of the indicative planning frameworks for transport and spatial development. In this article we investigate

  12. Design for Life. Abortion. A Student's Lesson Plan [and] A Teacher's Lesson Plan [and] A Lawyer's Lesson Plan.

    Science.gov (United States)

    Howard, Estelle; And Others

    One of a series of secondary level teaching units presenting case studies with pro and con analyses of particular legal problems, the document consists of a student's lesson plan, a teacher's lesson plan, and a lawyer's lesson plan for a unit on abortion. The lessons are designed to expose students to the Supreme Court's decision concerning…

  13. How to design a financial planning model.

    Science.gov (United States)

    Hayen, R L

    1983-10-01

    Corporate planning models frequently consist of integrated pro forma income statements, statements of financial position, and cashflow statements. When implemented by utilizing computer-based planning systems, these models allow managers to explore potential decisions in 'what if?' planning analyses. The logic of an integrated financial statement planning model can be arranged following either a 'funds needed to balance approach' or a 'direct approach'. With a funds needed to balance approach total assets are set equal to total liabilities plus equities to satisfy this fundamental accounting identity. Logic in such models is often difficult to validate. In the direct approach, total assets are calculated independently of total liabilities plus equities providing an extremely strong test for model validation prior to using the model to assess 'what if' alternatives. In this paper, the author discusses the logic of integrated financial planning models and their implementation with computer-based planning systems. The funds need to balance approach and the direct approach are described and contrasted to assist corporate planners in evaluating and selecting a method for constructing the logic of corporate planning models.

  14. Hanford Site waste tank farm facilities design reconstitution program plan

    Energy Technology Data Exchange (ETDEWEB)

    Vollert, F.R.

    1994-09-06

    Throughout the commercial nuclear industry the lack of design reconstitution programs prior to the mid 1980`s has resulted in inadequate documentation to support operating facilities configuration changes or safety evaluations. As a result, many utilities have completed or have ongoing design reconstitution programs and have discovered that without sufficient pre-planning their program can be potentially very expensive and may result in end-products inconsistent with the facility needs or expectations. A design reconstitution program plan is developed here for the Hanford waste tank farms facility as a consequence of the DOE Standard on operational configuration management. This design reconstitution plan provides for the recovery or regeneration of design requirements and basis, the compilation of Design Information Summaries, and a methodology to disposition items open for regeneration that were discovered during the development of Design Information Summaries. Implementation of this plan will culminate in an end-product of about 30 Design Information Summary documents. These documents will be developed to identify tank farms facility design requirements and design bases and thereby capture the technical baselines of the facility. This plan identifies the methodology necessary to systematically recover documents that are sources of design input information, and to evaluate and disposition open items or regeneration items discovered during the development of the Design Information Summaries or during the verification and validation processes. These development activities will be governed and implemented by three procedures and a guide that are to be developed as an outgrowth of this plan.

  15. Designing Micro- and Nanoswimmers for Specific Applications.

    Science.gov (United States)

    Katuri, Jaideep; Ma, Xing; Stanton, Morgan M; Sánchez, Samuel

    2017-01-17

    Self-propelled colloids have emerged as a new class of active matter over the past decade. These are micrometer sized colloidal objects that transduce free energy from their surroundings and convert it to directed motion. The self-propelled colloids are in many ways, the synthetic analogues of biological self-propelled units such as algae or bacteria. Although they are propelled by very different mechanisms, biological swimmers are typically powered by flagellar motion and synthetic swimmers are driven by local chemical reactions, they share a number of common features with respect to swimming behavior. They exhibit run-and-tumble like behavior, are responsive to environmental stimuli, and can even chemically interact with nearby swimmers. An understanding of self-propelled colloids could help us in understanding the complex behaviors that emerge in populations of natural microswimmers. Self-propelled colloids also offer some advantages over natural microswimmers, since the surface properties, propulsion mechanisms, and particle geometry can all be easily modified to meet specific needs. From a more practical perspective, a number of applications, ranging from environmental remediation to targeted drug delivery, have been envisioned for these systems. These applications rely on the basic functionalities of self-propelled colloids: directional motion, sensing of the local environment, and the ability to respond to external signals. Owing to the vastly different nature of each of these applications, it becomes necessary to optimize the design choices in these colloids. There has been a significant effort to develop a range of synthetic self-propelled colloids to meet the specific conditions required for different processes. Tubular self-propelled colloids, for example, are ideal for decontamination processes, owing to their bubble propulsion mechanism, which enhances mixing in systems, but are incompatible with biological systems due to the toxic propulsion fuel and

  16. Reflexive Planning as Design and Work

    DEFF Research Database (Denmark)

    Lissandrello, Enza; Grin, John

    2011-01-01

    In recent years, planning theorists have advanced various interpretations of the notion of reflexivity, inspired by American pragmatism, complexity theory, hermeneutics, discursive and collaborative planning. Scholars agree that “reflexivity” has a strong temporal dimension: it not only aims...... to solve present planning problems, but to imagine and understand alternative trajectories for future action. This article explores the practical utility of reflexivity for planners, through a case study that focuses on a project to promote sustainable development in the Port of Amsterdam. Reflexivity...... in planning emerges as a new tool for generating critical knowledge and dialogue that can synthesise the perspectives of multiple actors in a common understanding, existing structural constraints and a collective imagination of alternative future possibilities. Such research highlights the potential...

  17. Reflexive Planning as Design and Work

    DEFF Research Database (Denmark)

    Lissandrello, Enza; Grin, John

    2011-01-01

    In recent years, planning theorists have advanced various interpretations of the notion of reflexivity, inspired by American pragmatism, complexity theory, hermeneutics, discursive and collaborative planning. Scholars agree that “reflexivity” has a strong temporal dimension: it not only aims...... to solve present planning problems, but to imagine and understand alternative trajectories for future action. This article explores the practical utility of reflexivity for planners, through a case study that focuses on a project to promote sustainable development in the Port of Amsterdam. Reflexivity...... in planning emerges as a new tool for generating critical knowledge and dialogue that can synthesise the perspectives of multiple actors in a common understanding, existing structural constraints and a collective imagination of alternative future possibilities. Such research highlights the potential...

  18. Designing tomorrow: creative and effective succession planning.

    Science.gov (United States)

    Beglinger, Joan Ellis

    2013-10-01

    This department column is devoted to posing thought-provoking insights about transitions through, to, and from administrative roles in nursing. In this article, I explore an effective approach to succession planning for the role of director of surgical services, implemented in my role as chief nursing officer for a tertiary, acute care hospital. The plan provided a creative solution to the succession challenge and important lessons learned.

  19. Exploring How Experience with Planning Impacts First Grade Students' Planning and Solutions to Engineering Design Problems

    Science.gov (United States)

    Portsmore, Merredith D.

    2010-01-01

    This dissertation presents research that investigated how first grade students' ability to construct solutions and to plan through drawing for engineering design problems is related to their participation in a LEGO-based engineering curriculum with two variations on the instruction for planning. The quasi-experimental design engaged two first…

  20. Marketing Plan for Design Jewelry : Case Anniina Dunder

    OpenAIRE

    Dunder, Mikaela

    2008-01-01

    Jewelry designers might not be as customer-centered as Kotler recommend. Additionally, they are not constantly seeking to grow and make the most profit out of satisfying consumer needs better than competitors. However, it is imperative even for an individual designer to examine what the customers want and demand as well as think of a plan to satisfy this demand. Consequently, the purpose of this study is to create a guideline for a marketing plan for a beginning jewelry designers using jewelr...

  1. Compiler writing system detail design specification. Volume 1: Language specification

    Science.gov (United States)

    Arthur, W. J.

    1974-01-01

    Construction within the Meta language for both language and target machine specification is reported. The elements of the function language as a meaning and syntax are presented, and the structure of the target language is described which represents the target dependent object text representation of applications programs.

  2. ROUTE PLAN DESIGNER FOR TRACTOR GUIDANCE SYSTEMS

    DEFF Research Database (Denmark)

    Sveistrup, Daniel; Jørgensen, Rasmus Nyholm; Green, Ole

    2010-01-01

    Earlier works have shown field trial designs to be very labor extensive, even when combining autoguidancesystems with conventional machinery.Designing routes for semi-automated systems in a controlled manner is both resource demandingand complicated. Different types of auto-guidance systems vary...... was outlined, it took less thanone hour entering the design into the software and generating the auto-guidance files.KeywordsGIS, Auto steering systems, plot trial design, full-scale field trials, Java...

  3. Planning an Injection Mold Design Training Program.

    Science.gov (United States)

    Allyn, Edward P.

    With the increased use of plastics worldwide the shortage of trained personnel in moldmaking and design for plastic injection molds is becoming critical. Local schools and community colleges should provide courses in mold design and mold making, since most workers presently learn while working under experienced designers on the job. Following this…

  4. [Specific care plan in different stages of Alzheimer's disease].

    Science.gov (United States)

    Hein, Christophe; Villars, Hélène; Nourhashemi, Fati

    2011-09-01

    The management and follow-up of patients with Alzheimers disease have stage-specific characteristics. In the mild stage, the key challenges are above all to improve the early diagnosis and the communication of the diagnosis. With the patient's agreement, a follow-up should be scheduled to assess, at each stage of the disease, cognitive and functional decline, and detect psycho-behavioral, nutritional or mobility complications. In the moderate or severe stages, prevention and treatment of caregiver burnout should be included in the follow-up. Finally, in the very severe stage, end of life and ethical issues should be considered. The followup and the intervention plan should be adapted to each patient, and require coordination between health care professionals and social workers. However, the practical aspects of the follow-up and the ways in which those can be improved are yet to be defined.

  5. A Novel CAPP System Based on SML for Variant Design of Process Planning

    Institute of Scientific and Technical Information of China (English)

    ZHAO Haibin; WANG Junying; ZHANG Min

    2006-01-01

    The production model of "multi-specification and low-quantity" is becoming the main trend of manufacturing industry. As a key activity in the manufacturing chain, traditional computer aided process planning (CAPP) system fails to adapt to the production model of customization. Therefore, a novel method for variant design of process planning was proposed to develop CAPP system based on Tabular Layouts of Article Characteristics (Sach-Merk Leisten in German and SML for short). With the support of standard database of master process planning documents which are developed by parameterization technique, and instance process planning for special product (instance product) can be generated automatically by the sub-system of variant design of process planning. Finally, a CAPP system was developed for process design of rotor of steam turbine to validate the feasibility and applicability of the method.

  6. Improved Lesson Planning with Universal Design for Learning (UDL)

    Science.gov (United States)

    Courey, Susan Joan; Tappe, Phyllis; Siker, Jody; LePage, Pam

    2013-01-01

    Efficient lesson planning with universal design for learning (UDL) enables teachers to more effectively meet students' individual needs. In this study, a comparison of lesson plans by teacher candidates in a teacher preparation program before and after UDL training is presented. After training, teachers (n = 45) incorporated more differentiated…

  7. Patient-specific dosimetric endpoints based treatment plan quality control in radiotherapy.

    Science.gov (United States)

    Song, Ting; Staub, David; Chen, Mingli; Lu, Weiguo; Tian, Zhen; Jia, Xun; Li, Yongbao; Zhou, Linghong; Jiang, Steve B; Gu, Xuejun

    2015-11-07

    In intensity modulated radiotherapy (IMRT), the optimal plan for each patient is specific due to unique patient anatomy. To achieve such a plan, patient-specific dosimetric goals reflecting each patient's unique anatomy should be defined and adopted in the treatment planning procedure for plan quality control. This study is to develop such a personalized treatment plan quality control tool by predicting patient-specific dosimetric endpoints (DEs). The incorporation of patient specific DEs is realized by a multi-OAR geometry-dosimetry model, capable of predicting optimal DEs based on the individual patient's geometry. The overall quality of a treatment plan is then judged with a numerical treatment plan quality indicator and characterized as optimal or suboptimal. Taking advantage of clinically available prostate volumetric modulated arc therapy (VMAT) treatment plans, we built and evaluated our proposed plan quality control tool. Using our developed tool, six of twenty evaluated plans were identified as sub-optimal plans. After plan re-optimization, these suboptimal plans achieved better OAR dose sparing without sacrificing the PTV coverage, and the dosimetric endpoints of the re-optimized plans agreed well with the model predicted values, which validate the predictability of the proposed tool. In conclusion, the developed tool is able to accurately predict optimally achievable DEs of multiple OARs, identify suboptimal plans, and guide plan optimization. It is a useful tool for achieving patient-specific treatment plan quality control.

  8. ROUTE PLAN DESIGNER FOR TRACTOR GUIDANCE SYSTEMS

    DEFF Research Database (Denmark)

    Sveistrup, Daniel; Jørgensen, Rasmus Nyholm; Green, Ole

    2010-01-01

    Earlier works have shown field trial designs to be very labor extensive, even when combining autoguidancesystems with conventional machinery.Designing routes for semi-automated systems in a controlled manner is both resource demandingand complicated. Different types of auto-guidance systems vary....... The software works in conjunction with Google Earth to import field boundaries,and for viewing, validating and georeferencing completed field trial designs. The software isplatform independent and online distributed by means of the Java development environment.Two case studies were applied for demonstrating...... was outlined, it took less thanone hour entering the design into the software and generating the auto-guidance files.KeywordsGIS, Auto steering systems, plot trial design, full-scale field trials, Java...

  9. Functional Planning and Design of a Fan Shaped Technical Museum

    Directory of Open Access Journals (Sweden)

    Dr. Lovely K M

    2014-04-01

    Full Text Available The proposed building aims at the development of the built environment. The principal objective of this paper is the functional planning, analysis and design of a fan shaped technical museum. Technical museum is a museum that tells the stories of architecture, engineering and design. The functional planning was done according to the clauses given by Museum Building Design and Exhibition Layout: Patterns of Interactions, ICOM Code of Ethics for Museum, and Key Concepts of Museology. Plan, elevation and section were drawn in AutoCAD 2010. The design involves load calculations and analyzing the whole structure by STAAD.ProV8i. The design methods used in STAAD.ProV8i analysis are limit state design conforming to Indian Standard Code of practice. Also the building was analyzed for all possible load combinations.

  10. The New Schools. Design & Planning Series.

    Science.gov (United States)

    Morisseau, James J.

    This document is one part of a series intended to provide modern pattern books for architects and planners in need of practical solutions to specific problems. Each volume in the series is concerned with structures built for a specific purpose and contains several dozen projects that are good examples of such structures. This volume contains data…

  11. Project specific quality assurance plan, W-151, Tank 241-AZ-101 waste retrieval system. Revision 2

    Energy Technology Data Exchange (ETDEWEB)

    Manthei, M.E.

    1994-11-21

    This project specific quality assurance program plan establishes the responsibility for the implementation of QA requirements, defines and documents the QA requirements associated with design, procurement, and construction, and defines and documents the degree of QA reviews and verifications on the design and construction necessary to assure compliance to project and DOE requirements. Revision 2 updates the QAPP to provide concurrence with approved work scope deletion. In addition, the Quality Assurance Program Index is being updated to reflect the current Quality Assurance Program requirements per DOE Order 5700.6C.

  12. Integration of packaging design and planning into transportation

    Energy Technology Data Exchange (ETDEWEB)

    Jarrell, R.F. (USDOE Richland Field Office, WA (United States))

    1993-01-01

    In the past, numerous programs, projects, and design concepts for packaging and materials production have taken place without all the principal participants being involved in the up-front planning process. Many major facilities and packagings have been designed without the involvement of Transportation professionals. Unfortunately, Transportation has been overlooked and in most cases is a critical element that should have been included in the Planning process. (J.P.N.).

  13. Planning and Design for Eco-Sustainable Farmland Consolidation

    Institute of Scientific and Technical Information of China (English)

    BAO Hai-Jun; WU Yu-Zhe; WU Ci-Fang; XU Bao-Gen

    2005-01-01

    With a view of sustainable development, different kinds of farmland consolidation are reviewed. A planning and design mode for eco-sustainable farmland consolidation, which integrated the ecotypic board, the ecotypic tunnel, the ecotypic island, and the ecotypic boundary, is proposed. Then, an actual case of farmland consolidation, a project located in Yinzhou County, Zhejiang Province, is used to demonstrate the effective application procedures of the planning and design mode.

  14. ROUTE PLAN DESIGNER FOR TRACTOR GUIDANCE SYSTEMS

    DEFF Research Database (Denmark)

    Sveistrup, Daniel; Jørgensen, Rasmus Nyholm; Green, Ole

    2010-01-01

    in their file formats and operationalrequirements, thereby creating an unnecessary burden for the field trial managers and researchersoperating on different computational platforms such as Windows, Mac or Linux.This paper demonstrates a methodological proof of concept for a software solution for assisting....... The software works in conjunction with Google Earth to import field boundaries,and for viewing, validating and georeferencing completed field trial designs. The software isplatform independent and online distributed by means of the Java development environment.Two case studies were applied for demonstrating...... the benefits of the software. 1- a modified fullscalerandomized split-plot design of 840 parcels and 15 treatment combinations. 2 - a maize fieldsetup ensuring a prototype crop-weed detection camera to experience as many crops, weed and soilcolor conditions as possible. For both cases, after the overall layout...

  15. 7 CFR 1753.26 - Plans and specifications (P&S).

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 11 2010-01-01 2010-01-01 false Plans and specifications (P&S). 1753.26 Section 1753... Buildings § 1753.26 Plans and specifications (P&S). (a) For headquarters and commercial office buildings only, the borrower shall prepare preliminary P&S showing the floor plan and general...

  16. Chapter 3. Planning and design for habitat monitoring

    Science.gov (United States)

    Christina D. Vojta; Lyman L. McDonald; C. Kenneth Brewer; Kevin S. McKelvey; Mary M Rowland; Michael I. Goldstein

    2013-01-01

    This chapter provides guidance for designing a habitat monitoring program so that it will meet the monitoring objective, will be repeatable, and will adequately represent habitat within the spatial extent of interest. Although a number of excellent resources are available for planning and designing a monitoring program for wildlife populations (e.g., Busch and Trexler...

  17. Planned Missing Data Designs for Research in Cognitive Development

    Science.gov (United States)

    Rhemtulla, Mijke; Little, Todd D.

    2012-01-01

    Data collection can be the most time- and cost-intensive part of developmental research. This article describes some long-proposed but little-used research designs that have the potential to maximize data quality (reliability and validity) while minimizing research cost. In "planned missing data designs", missing data are used…

  18. Applying Universal Design for Learning to Instructional Lesson Planning

    Science.gov (United States)

    McGhie-Richmond, Donna; Sung, Andrew N.

    2013-01-01

    Universal Design for Learning is a framework for developing inclusive instructional lesson plans. The effects of introducing Universal Design for Learning Principles and Guidelines in a university teacher education program with pre-service and practicing teachers were explored in a mixed methods approach. The results indicate that the study…

  19. Planned Missing Data Designs in Educational Psychology Research

    Science.gov (United States)

    Rhemtulla, Mijke; Hancock, Gregory R.

    2016-01-01

    Although missing data are often viewed as a challenge for applied researchers, in fact missing data can be highly beneficial. Specifically, when the amount of missing data on specific variables is carefully controlled, a balance can be struck between statistical power and research costs. This article presents the issue of planned missing data by…

  20. Planned Missing Data Designs in Educational Psychology Research

    Science.gov (United States)

    Rhemtulla, Mijke; Hancock, Gregory R.

    2016-01-01

    Although missing data are often viewed as a challenge for applied researchers, in fact missing data can be highly beneficial. Specifically, when the amount of missing data on specific variables is carefully controlled, a balance can be struck between statistical power and research costs. This article presents the issue of planned missing data by…

  1. The Hierarchical Specification and Mechanical Verification of the SIFT Design

    Science.gov (United States)

    1983-01-01

    The formal specification and proof methodology employed to demonstrate that the SIFT computer system meets its requirements are described. The hierarchy of design specifications is shown, from very abstract descriptions of system function down to the implementation. The most abstract design specifications are simple and easy to understand, almost all details of the realization were abstracted out, and are used to ensure that the system functions reliably and as intended. A succession of lower level specifications refines these specifications into more detailed, and more complex, views of the system design, culminating in the Pascal implementation. The section describes the rigorous mechanical proof that the abstract specifications are satisfied by the actual implementation.

  2. Life-Cycle Finance and the Design of Pension Plans

    OpenAIRE

    Zvi Bodie; Jérôme Detemple; Marcel Rindisbacher

    2009-01-01

    This article reviews recent scientific literature on consumer financial decisions over the life cycle, outlining its implications for the design of pension plans. It begins with a review of advances in the theory of rational financial planning and wealth management. It then summarizes the recent empirical literature on the actual behavior of households regarding saving, investing, and insuring their consumption in old age. Finally, it briefly comments on the practical implications of the theo...

  3. Interim measure work plan/design for Agra, Kansas.

    Energy Technology Data Exchange (ETDEWEB)

    LaFreniere, L. M.; Environmental Science Division

    2008-11-18

    This Interim Measure Work Plan/Design (IMWP/D) is supplemental to the Argonne document Interim Measure Conceptual Design for Remediation of Source Area Contamination at Agra, Kansas. The IMWP/D includes information required by Kansas Department of Health and Environment (KDHE) Policy BER-RS-029, Policy and Scope of Work for Interim Measures. Specific to Policy BER-RS-029 is the requirement for several documents that will ensure that an adequate amount and type of data are collected for implementation of the IMWP/D and that data quality and safe conditions are prevailed. Such information is included in the IMWP/D as follows: Appendix A: Data Acquisition Plan--Design Testing Requirements; Appendix B: Basis of Design; Appendix C: Permits; Appendix D: Quality Assurance Project Plan; Appendix E: Health and Safety Plan; and Appendix F: Operations, Maintenance, and Monitoring Schedule. The proposed remedial technology for this project is the installation of five large-diameter boreholes (LDBs) in a source area that has been identified on the property formerly used for grain storage by the Commodity Credit Corporation of the U.S. Department of Agriculture (CCC/USDA). The goal of the LDB technology is the remediation of the source area by removal of mass quantities of contaminated soil from the vadose zone and treatment of any remaining contaminated soils that are adjacent to the source area to achieve a carbon tetrachloride concentration below 200 {micro}g/kg. Secondary to the soil remediation is the remediation of groundwater at and adjacent to the source areas. The LDB technology serves the following purposes: (1) The physical removal of contaminated soil from the identified source area. (2) Replacement of less permeable native materials (silty clay, clayey silt, and silty sand) with more permeable materials to facilitate the capture of volatilized contaminants in the vertical borehole. (3) Removal of contaminants volatilized by air sparging (AS) and extracted from the

  4. AFEII Analog Front End Board Design Specifications

    Energy Technology Data Exchange (ETDEWEB)

    Rubinov, Paul; /Fermilab

    2005-04-01

    This document describes the design of the 2nd iteration of the Analog Front End Board (AFEII), which has the function of receiving charge signals from the Central Fiber Tracker (CFT) and providing digital hit pattern and charge amplitude information from those charge signals. This second iteration is intended to address limitations of the current AFE (referred to as AFEI in this document). These limitations become increasingly deleterious to the performance of the Central Fiber Tracker as instantaneous luminosity increases. The limitations are inherent in the design of the key front end chips on the AFEI board (the SVXIIe and the SIFT) and the architecture of the board itself. The key limitations of the AFEI are: (1) SVX saturation; (2) Discriminator to analog readout cross talk; (3) Tick to tick pedestal variation; and (4) Channel to channel pedestal variation. The new version of the AFE board, AFEII, addresses these limitations by use of a new chip, the TriP-t and by architectural changes, while retaining the well understood and desirable features of the AFEI board.

  5. Optimizing Traffic Operation in Designing Specific Upgrades

    Directory of Open Access Journals (Sweden)

    Ebrahim Sangsefidi

    2015-01-01

    Full Text Available Transport forms one of the primary needs in all categories of the population in modern society; it is of paramount concern for traffic engineers, transport planners, and policy makers to understand and evaluate the quality of service being provided by the transport facilities designed by them. This paper presents an investigation in profile geometric design and traffic flow operation on two-lane two-way highways and provides analyses that will help in a better understanding of traffic operation on these facilities to select the optimum profile configuration. The effects of influencing parameters consisting of grade, length of grade, traffic composition, and traffic volume are evaluated and finally a systematic procedure to evaluate flow rate under the base condition is presented. Finally, based on these achievements an algorithm is introduced to select optimum Finished Ground of profile view. Results show that the percentage of heavy vehicles has a contributing effect on traffic operation so that the optimum profile configuration is incredibly affected by this factor. Source data have been obtained from Highway Capacity Manual (HCM as a pioneer document in respect of quantifying the concept of capacity for a transport facility.

  6. An architecture for design and planning of mobile television networks

    Directory of Open Access Journals (Sweden)

    R. Tamayo-Fernández

    2011-12-01

    Full Text Available Mobile television (TV, made possible by the convergence of media, telecommunications and consumer electronicsindustries, is one of the most hyped new mobile services in several countries [1]. The advertised key features ofmobile TV are personalization, interactivity, and most importantly, the ability to watch TV programming while on thego. The deployment of a mobile TV network consists of several stages that require careful planning. There are available simulation packages for designing wireless technologies, however, for mobile TV there are still planning and simulations concerns that have to be addressed in order to identify its design challenges. This article reviews the main parameters that should be taken into account to support the design and planning of a mobile TV network andproposes an architecture for its implementation.

  7. Canadian STARS-Rated Campus Sustainability Plans: Priorities, Plan Creation and Design

    Directory of Open Access Journals (Sweden)

    Lauri Lidstone

    2015-01-01

    Full Text Available The use of integrated sustainability plans is an emerging trend in higher education institutions (HEIs to set sustainability priorities and to create a work plan for action. This paper analyses the sustainability plans of 21 Canadian HEIs that have used the Sustainability Tracking, Assessment and Rating System (STARS from the Association for the Advancement of Sustainability in Higher Education (AASHE. The plans were coded thematically with a focus on the sustainability goals, process of plan creation, and aspects of plan design outlined in the texts. This paper finds that sustainability goals focused on the environmental aspects of sustainability, while social and economic aspects were less emphasized. Further, most plans were described as being created through a broad stakeholder-consultation process, while fewer plans assigned timelines and parties responsible to sustainability goals. This paper contributes to our understanding of the priorities of Canadian HEI institutions at the end of the Decade of Education for Sustainable Development and is useful for practitioners interested in developing their own sustainability plans.

  8. Acoustic design of open plan schools and comparison of requirements

    DEFF Research Database (Denmark)

    Møller Petersen, Claus; Rasmussen, Birgit

    2012-01-01

    between groups and satisfac¬tory speech intelligibility internally in groups. This paper describes the newest Danish requirements and recommendations for such open plan areas and presents the design, measurements and subjective evaluation of two newer Danish schools. According to the users, the general......In the Nordic countries several new schools have open plan areas for teaching and group work. However, to optimize learning efficiency for pupils and working conditions for teachers and to reduce noise levels, such spaces require special acoustic design to obtain sufficient sound attenuation...

  9. A comprehensive scoring system to measure healthy community design in land use plans and regulations.

    Science.gov (United States)

    Maiden, Kristin M; Kaplan, Marina; Walling, Lee Ann; Miller, Patricia P; Crist, Gina

    2017-02-01

    Comprehensive land use plans and their corresponding regulations play a role in determining the nature of the built environment and community design, which are factors that influence population health and health disparities. To determine the level in which a plan addresses healthy living and active design, there is a need for a systematic, reliable and valid method of analyzing and scoring health-related content in plans and regulations. This paper describes the development and validation of a scoring tool designed to measure the strength and comprehensiveness of health-related content found in land use plans and the corresponding regulations. The measures are scored based on the presence of a specific item and the specificity and action-orientation of language. To establish reliability and validity, 42 land use plans and regulations from across the United States were scored January-April 2016. Results of the psychometric analysis indicate the scorecard is a reliable scoring tool for land use plans and regulations related to healthy living and active design. Intraclass correlation coefficients (ICC) scores showed strong inter-rater reliability for total strength and comprehensiveness. ICC scores for total implementation scores showed acceptable consistency among scorers. Cronbach's alpha values for all focus areas were acceptable. Strong content validity was measured through a committee vetting process. The development of this tool has far-reaching implications, bringing standardization of measurement to the field of land use plan assessment, and paving the way for systematic inclusion of health-related design principles, policies, and requirements in land use plans and their corresponding regulations.

  10. PC-based Multiple Information System Interface (PC/MISI) design plan

    Science.gov (United States)

    Dominick, Wayne D. (Editor); Hall, Philip P.

    1985-01-01

    The general design plan for the implementation of a common user interface to multiple remote information systems within a microcomputer-based environment is presented. The intent is to provide a framework for the development of detailed specifications which will be used as guidelines for the actual development of the system.

  11. Development strategies in design and process planning quality assurance context

    Directory of Open Access Journals (Sweden)

    J. Duda

    2010-07-01

    Full Text Available According to the new development strategies, the product development focuses on as much as possible parallel execution of alldevelopment related product life cycle phases, thus creating CE (Concurrent Engineering approach. Its further extension is CEE (CrossEnterprises Engineering approach incorporating the relations between business and engineering activities, so securing also the access tothe resources of cooperating enterprises. Computer integration of product phases can be viewed as functional, informational and complexintegration. The process planning quality is assured on the design and technological process planning stage with the use of methods andsystems processing the data from the other product development phases. The paper presents the methods and systems for design andprocess planning quality assurance in the product life cycle as well as the possibility for the implementation of the presented productdevelopment phases.

  12. Operational research models in warehouse design and planning

    OpenAIRE

    Geraldes, Carla A. S.; Carvalho, Sameiro; Pereira, Guilherme

    2010-01-01

    The design and operation of a warehouse involve many challenging decision problems. In this paper, a literature review on warehousing models is presented. Authors start with a hierarchy of decision problems encountered in setting up warehouse design and planning processes. Next, some operational research decision models and solution algorithms supporting decision making at each discussed level are presented. The aim is to link academic researchers and warehouse practitioners, explaining what ...

  13. An integrated approach for warehouse design and planning

    OpenAIRE

    Pereira, Guilherme; Geraldes, Carla Alexandra Soares; Carvalho, Maria Sameiro

    2011-01-01

    Warehouse design and planning is a great challenge in the field of Supply Chain Management. Inventory level management, warehouse design and operations, and customers’ requirements are examples of important challenges in this context. Throughout this work we discuss a mathematical model aiming to support some warehouse management decisions and inventory decisions. Our aim is to show model’s potentialities and weaknesses when applied to real world problems and to identify challenging research ...

  14. Development of Planning Abilities in Normal Aging: Differential Effects of Specific Cognitive Demands

    Science.gov (United States)

    Köstering, Lena; Stahl, Christoph; Leonhart, Rainer; Weiller, Cornelius; Kaller, Christoph P.

    2014-01-01

    In line with the frontal hypothesis of aging, the ability to plan ahead undergoes substantial change during normal aging. Although impairments on the Tower of London planning task were reported earlier, associations between age-related declines and specific cognitive demands on planning have not been studied. Here we investigated the impact of…

  15. Development of Planning Abilities in Normal Aging: Differential Effects of Specific Cognitive Demands

    Science.gov (United States)

    Köstering, Lena; Stahl, Christoph; Leonhart, Rainer; Weiller, Cornelius; Kaller, Christoph P.

    2014-01-01

    In line with the frontal hypothesis of aging, the ability to plan ahead undergoes substantial change during normal aging. Although impairments on the Tower of London planning task were reported earlier, associations between age-related declines and specific cognitive demands on planning have not been studied. Here we investigated the impact of…

  16. 46 CFR 162.050-21 - Separator: Design specification.

    Science.gov (United States)

    2010-10-01

    ... MATERIALS: SPECIFICATIONS AND APPROVAL ENGINEERING EQUIPMENT Pollution Prevention Equipment § 162.050-21 Separator: Design specification. (a) A separator must be designed to operate in each plane that forms an angle of 22.5° with the plane of its normal operating position. (b) The electrical components of...

  17. Acoustical Considerations in Planning and Design of Library Facilities.

    Science.gov (United States)

    Wrightson, Denelle; Wrightson, John M.

    1999-01-01

    Discusses acoustical demands in public libraries to consider during the design and construction process of new or renovated library space. Topics include intrusive noises; overly reverberant spaces; lack of speech privacy; sound transmission class; noise criteria; reverberation time and noise reduction coefficient; space planning; sound systems;…

  18. Robotic needle steering: design, modeling, planning, and image guidance

    NARCIS (Netherlands)

    Cowan, Noah J.; Goldberg, Ken; Chirikjian, Gregory S.; Fichtinger, Gabor; Alterovitz, Ron; Reed, Kyle B.; Kallem, Vinutha; Park, Wooram; Misra, Sarthak; Okamura, Allison M.; Rosen, Jacob; Hannaford, Blake; Satava, Richard M.

    2010-01-01

    This chapter describes how advances in needle design, modeling, planning, and image guidance make it possible to steer flexible needles from outside the body to reach specified anatomical targets not accessible using traditional needle insertion methods. Steering can be achieved using a variety of m

  19. Ethics, Design and Planning of the Built Environment

    NARCIS (Netherlands)

    Basta, C.; Moroni, S.

    2013-01-01

    The book proposes a set of original contributions in research areas shared by planning theory, architectural research, design and ethical inquiry. The contributors gathered in 2010 at the Ethics of the Built Environment seminar organized by the editors at Delft University of Technology. Both promine

  20. Hanford Integrated Planning Process: 1993 Hanford Site-specific science and technology plan

    Energy Technology Data Exchange (ETDEWEB)

    1993-12-01

    This document is the FY 1993 report on Hanford Site-specific science and technology (S&T) needs for cleanup of the Site as developed via the Hanford Integrated Planning Process (HIPP). It identifies cleanup problems that lack demonstrated technology solutions and technologies that require additional development. Recommendations are provided regarding allocation of funding to address Hanford`s highest-priority technology improvement needs, technology development needs, and scientific research needs, all compiled from a Sitewide perspective. In the past, the S&T agenda for Hanford Site cleanup was sometimes driven by scientists and technologists, with minimal input from the ``problem owners`` (i.e., Westinghouse Hanford Company [WHC] staff who are responsible for cleanup activities). At other times, the problem-owners made decisions to proceed with cleanup without adequate scientific and technological inputs. Under both of these scenarios, there was no significant stakeholder involvement in the decision-making process. One of the key objectives of HIPP is to develop an understanding of the integrated S&T requirements to support the cleanup mission, (a) as defined by the needs of the problem owners, the values of the stakeholders, and the technology development expertise that exists at Hanford and elsewhere. This requires a periodic, systematic assessment of these needs and values to appropriately define a comprehensive technology development program and a complementary scientific research program. Basic to our success is a methodology that is defensible from a technical perspective and acceptable to the stakeholders.

  1. CONCEPTUAL MODEL OF MARKETING STRATEGIC PLANNING SPECIFIC TO PUBLIC ORGANIZATIONS

    Directory of Open Access Journals (Sweden)

    Ionescu Florin Tudor

    2012-12-01

    Full Text Available In public services, the political component of the marketing environment has a major importance, as all decisions adopted within central administration influence both the objectives and measures implemented by units of local government and other public service providers. Any discontinuity in the activity of such entities might result in neglecting the real needs of citizens and slowing the reform process in the public sector. Therefore, all initiatives of public organizations must have a unitary goal and integrate harmoniously within a single process. A tool from the management-marketing literature that both contributes to this purpose and leads to an increased customer satisfaction and organizational performance is strategic marketing planning. This paper presents, firstly, requirements and particularities of this process in the public sector, focusing on the need for bottom-up planning, meaning from the functional levels of public service organizations, to the corporate level, where strategic decisions are taken. To achieve this goal, there should be included in the planning process the clients and other audiences, which can provide useful information about the services they want, the quality or the accessibility thereof, and news about the services they need in the future. There are also mentioned the factors that can influence the quality of strategic marketing planning in public services domain: the importance of marketing within the organization, marketing knowledge of employees in marketing departments and/or of management personnel, the efficiency of activities within the organization, and the manager’s marketing vision. In the final part of the paper there are presented the stages of the conceptual model of strategic marketing planning in public services field: (1 accepting the idea of bottom-up planning, (2 avoid or eliminate discrepancies between measures taken at high levels and executions carried out at operational

  2. Architectural design - Conception and specification of interactive systems

    NARCIS (Netherlands)

    Vissers, C.A.; Ferreira Pires, Luis; Quartel, Dick; van Sinderen, Marten J.

    2016-01-01

    This book presents a design methodology that is practically applicable to the architectural design of a broad range of systems. It is based on fundamental design concepts to conceive and specify the required functional properties of a system, while abstracting from the specific implementation

  3. Design and analysis of advanced flight planning concepts

    Science.gov (United States)

    Sorensen, John A.

    1987-01-01

    The objectives of this continuing effort are to develop and evaluate new algorithms and advanced concepts for flight management and flight planning. This includes the minimization of fuel or direct operating costs, the integration of the airborne flight management and ground-based flight planning processes, and the enhancement of future traffic management systems design. Flight management (FMS) concepts are for on-board profile computation and steering of transport aircraft in the vertical plane between a city pair and along a given horizontal path. Flight planning (FPS) concepts are for the pre-flight ground based computation of the three-dimensional reference trajectory that connects the city pair and specifies the horizontal path, fuel load, and weather profiles for initializing the FMS. As part of these objectives, a new computer program called EFPLAN has been developed and utilized to study advanced flight planning concepts. EFPLAN represents an experimental version of an FPS. It has been developed to generate reference flight plans compatible as input to an FMS and to provide various options for flight planning research. This report describes EFPLAN and the associated research conducted in its development.

  4. Site Planning Here and There: Comparing Western Site Planning and Design and Eastern Feng Shui

    Directory of Open Access Journals (Sweden)

    Mintai Kim

    2004-06-01

    Full Text Available Feng Shui, in comparison with contemporary site design tools, employs a broad range of criteria in the observation and assessment of a site. Feng Shui includes information that is gathered at a different level of awareness and used to define what it is that causes a space to feel the way it does. As a result, Feng Shui may better respond to human needs and perceptions by providing the physical conditions that are comfortable for people using the space. One of the intentions of this study is to close the gap between Western ('here' and Eastern ('there' ideas. This study examines 1 whether or not Feng Shui and Western site planning are comparable, and 2 if Feng Shui can be a valid planning, design and evaluation tool for modern site planning. We examine and compare urban plazas from both Feng Shui and Western site planning perspectives. The study assessed a variety of existing urban places in the Tucson and Phoenix metropolitan areas, and Sedona, Arizona for conditions of human comfort as measured by 1 Feng Shui principles, and 2 contemporary site design recommendations. This study used the principles of Feng Shui as the criteria for evaluation of urban spaces based on human needs for physical comfort. Results of this study indicate that places that are well designed from a Feng Shui point of view are also perceived as well designed from a contemporary site design vantage. The outcome suggests that Feng Shui is a valuable tool in the site design process for Western designers.

  5. 7 CFR 1753.37 - Plans and specifications (P&S).

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 11 2010-01-01 2010-01-01 false Plans and specifications (P&S). 1753.37 Section 1753... Installation of Central Office Equipment § 1753.37 Plans and specifications (P&S). (a) General. (1) Prior to the preparation of P&S, the borrower shall review with the GFR the current and future requirements...

  6. 7 CFR 1753.47 - Plans and specifications (P&S).

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 11 2010-01-01 2010-01-01 false Plans and specifications (P&S). 1753.47 Section 1753... Construction by Contract § 1753.47 Plans and specifications (P&S). (a) General. (1) Prior to the preparation of P&S for the construction project: (i) A review shall be made of the outside plant requirements,...

  7. Why governance will make urban design and planning better: Dealing with the communicative turn in urban planning and design

    NARCIS (Netherlands)

    Rocco de Campos Pereira, R.C.

    2013-01-01

    Designing and planning cities are profoundly political activities. There are no purely value-free or ‘technical’ solutions to urban problems: all decisions in urban development are political decisions insofar they must involve choice, negotiation, friction and divergence and occasionally agreement

  8. Workspace experiments: a journey on planning participatory design

    DEFF Research Database (Denmark)

    Souza da Conceição, Carolina

    in a cooperative design setting. The material was gradually built during a research project, including three workshops emphasizing joint exploration by architects, consulting engineers and health & safety consultants. This method was used because we could discuss, explore, and try out various aspects of the new......, the resource material was well accepted during a training section and some participants were happy they in fact used the time during the session to solve some planning issues for their projects. The material became an asset that streamlined the planning of a participatory process while putting the key themes...

  9. 24 CFR 1003.205 - Eligible planning, urban environmental design and policy-planning-management-capacity building...

    Science.gov (United States)

    2010-04-01

    ... environmental design and policy-planning-management-capacity building activities. 1003.205 Section 1003.205... planning, urban environmental design and policy-planning-management-capacity building activities. (a... cost of such activities under §§ 1003.201 through 1003.204. (b) Policy—planning—management—capacity...

  10. 24 CFR 570.205 - Eligible planning, urban environmental design and policy-planning-management-capacity building...

    Science.gov (United States)

    2010-04-01

    ... environmental design and policy-planning-management-capacity building activities. 570.205 Section 570.205..., urban environmental design and policy-planning-management-capacity building activities. (a) Planning... known or suspected environmental contamination. (5) (6) Policy—planning—management—capacity building...

  11. Effects of preparatory and action planning instructions on situation-specific and general fruit and snack intake.

    Science.gov (United States)

    de Bruijn, Gert-Jan; Nguyen, Minh Hao; Rhodes, Ryan E; van Osch, Liesbeth

    2017-01-01

    Evidence to date suggests heterogeneity in the effects of implementation intentions on health behaviour, including diet. Additional variables and study designs may impact on their effectiveness. Preparatory action, such as making sure fruits are available for consumption, may be an important additional variable. Likewise, most implementation intention research has focused on changes in general intake, yet implementation intention instructions typically require participants to consider behaviour in specific situations. Little is known on how implementation intentions impact situation-specific intake. The present study sought to add to the evidence base by comparing (1) the effects of action planning instructions versus preparatory planning instructions on (2) both situation-specific (as formulated in the implementation intention instruction) and general intake of fruits and in-between meal snack intake frequency. Fruit intake was assessed in average pieces per day, whereas snacking intake was assessed as average frequency in days per week. Using non-probability sampling, 243 undergraduate students who intended to have a healthy diet were randomized to either a standard information control condition, an action planning condition, or a preparatory planning condition. Planning manipulations were based on previous work. Two weeks later, general and situation-specific intake was assessed again in 181 participants. Data were analysed using 2 (time) x 3 (conditions) analyses of variance. Results showed that both planning manipulations were successful in decreasing snack intake frequency in the specified situation, with larger effect sizes for the action planning condition than for the preparatory planning condition. No effects were found on general snack intake frequency or fruit intake. Future planning interventions should more explicitly compare changes in situational and general intake, as well as simultaneously assessed decreases in unhealthy intake and increases in

  12. Transitioning from conceptual design to construction performance specification

    Science.gov (United States)

    Jeffers, Paul; Warner, Mark; Craig, Simon; Hubbard, Robert; Marshall, Heather

    2012-09-01

    On successful completion of a conceptual design review by a funding agency or customer, there is a transition phase before construction contracts can be placed. The nature of this transition phase depends on the Project's approach to construction and the particular subsystem being considered. There are generically two approaches; project retention of design authority and issuance of build to print contracts, or issuance of subsystem performance specifications with controlled interfaces. This paper relates to the latter where a proof of concept (conceptual or reference design) is translated into performance based sub-system specifications for competitive tender. This translation is not a straightforward process and there are a number of different issues to consider in the process. This paper deals with primarily the Telescope mount and Enclosure subsystems. The main subjects considered in this paper are: • Typical status of design at Conceptual Design Review compared with the desired status of Specifications and Interface Control Documents at Request for Quotation. • Options for capture and tracking of system requirements flow down from science / operating requirements and sub-system requirements, and functional requirements derived from reference design. • Requirements that may come specifically from the contracting approach. • Methods for effective use of reference design work without compromising a performance based specification. • Management of project team's expectation relating to design. • Effects on cost estimates from reference design to actual. This paper is based on experience and lessons learned through this process on both the VISTA and the ATST projects.

  13. Surgeon Design Interface for Patient-Specific Concentric Tube Robots.

    Science.gov (United States)

    Morimoto, Tania K; Greer, Joseph D; Hsieh, Michael H; Okamura, Allison M

    2016-06-01

    Concentric tube robots have potential for use in a wide variety of surgical procedures due to their small size, dexterity, and ability to move in highly curved paths. Unlike most existing clinical robots, the design of these robots can be developed and manufactured on a patient- and procedure-specific basis. The design of concentric tube robots typically requires significant computation and optimization, and it remains unclear how the surgeon should be involved. We propose to use a virtual reality-based design environment for surgeons to easily and intuitively visualize and design a set of concentric tube robots for a specific patient and procedure. In this paper, we describe a novel patient-specific design process in the context of the virtual reality interface. We also show a resulting concentric tube robot design, created by a pediatric urologist to access a kidney stone in a pediatric patient.

  14. Generating patient-specific pulmonary vascular models for surgical planning

    Science.gov (United States)

    Murff, Daniel; Co-Vu, Jennifer; O'Dell, Walter G.

    2015-03-01

    Each year in the U.S., 7.4 million surgical procedures involving the major vessels are performed. Many of our patients require multiple surgeries, and many of the procedures include "surgical exploration". Procedures of this kind come with a significant amount of risk, carrying up to a 17.4% predicted mortality rate. This is especially concerning for our target population of pediatric patients with congenital abnormalities of the heart and major pulmonary vessels. This paper offers a novel approach to surgical planning which includes studying virtual and physical models of pulmonary vasculature of an individual patient before operation obtained from conventional 3D X-ray computed tomography (CT) scans of the chest. These models would provide clinicians with a non-invasive, intricately detailed representation of patient anatomy, and could reduce the need for invasive planning procedures such as exploratory surgery. Researchers involved in the AirPROM project have already demonstrated the utility of virtual and physical models in treatment planning of the airways of the chest. Clinicians have acknowledged the potential benefit from such a technology. A method for creating patient-derived physical models is demonstrated on pulmonary vasculature extracted from a CT scan with contrast of an adult human. Using a modified version of the NIH ImageJ program, a series of image processing functions are used to extract and mathematically reconstruct the vasculature tree structures of interest. An auto-generated STL file is sent to a 3D printer to create a physical model of the major pulmonary vasculature generated from 3D CT scans of patients.

  15. Specific primer design for the polymerase chain reaction.

    Science.gov (United States)

    Chuang, Li-Yeh; Cheng, Yu-Huei; Yang, Cheng-Hong

    2013-10-01

    The design of primers has a major impact on the success of PCR in relation to the specificity and yield of the amplified product. Here, we introduce the applications of PCR as well as the definition and characteristics for PCR primer design. Recent primer design tools based on Primer3, along with several computational intelligence-based primer design methods which have been applied in primer design, are also reviewed. In addition, characteristics of population-based methods used in primer design are discussed in detail.

  16. Incorporating climate change projections into riparian restoration planning and design

    Science.gov (United States)

    Perry, Laura G.; Lindsay V. Reynolds,; Beechie, Timothy J.; Collins, Mathias J.; Shafroth, Patrick B.

    2015-01-01

    Climate change and associated changes in streamflow may alter riparian habitats substantially in coming decades. Riparian restoration provides opportunities to respond proactively to projected climate change effects, increase riparian ecosystem resilience to climate change, and simultaneously address effects of both climate change and other human disturbances. However, climate change may alter which restoration methods are most effective and which restoration goals can be achieved. Incorporating climate change into riparian restoration planning and design is critical to long-term restoration of desired community composition and ecosystem services. In this review, we discuss and provide examples of how climate change might be incorporated into restoration planning at the key stages of assessing the project context, establishing restoration goals and design criteria, evaluating design alternatives, and monitoring restoration outcomes. Restoration planners have access to numerous tools to predict future climate, streamflow, and riparian ecology at restoration sites. Planners can use those predictions to assess which species or ecosystem services will be most vulnerable under future conditions, and which sites will be most suitable for restoration. To accommodate future climate and streamflow change, planners may need to adjust methods for planting, invasive species control, channel and floodplain reconstruction, and water management. Given the considerable uncertainty in future climate and streamflow projections, riparian ecological responses, and effects on restoration outcomes, planners will need to consider multiple potential future scenarios, implement a variety of restoration methods, design projects with flexibility to adjust to future conditions, and plan to respond adaptively to unexpected change.

  17. Patient specific optimization-based treatment planning for catheter-based ultrasound hyperthermia and thermal ablation

    Science.gov (United States)

    Prakash, Punit; Chen, Xin; Wootton, Jeffery; Pouliot, Jean; Hsu, I.-Chow; Diederich, Chris J.

    2009-02-01

    A 3D optimization-based thermal treatment planning platform has been developed for the application of catheter-based ultrasound hyperthermia in conjunction with high dose rate (HDR) brachytherapy for treating advanced pelvic tumors. Optimal selection of applied power levels to each independently controlled transducer segment can be used to conform and maximize therapeutic heating and thermal dose coverage to the target region, providing significant advantages over current hyperthermia technology and improving treatment response. Critical anatomic structures, clinical target outlines, and implant/applicator geometries were acquired from sequential multi-slice 2D images obtained from HDR treatment planning and used to reconstruct patient specific 3D biothermal models. A constrained optimization algorithm was devised and integrated within a finite element thermal solver to determine a priori the optimal applied power levels and the resulting 3D temperature distributions such that therapeutic heating is maximized within the target, while placing constraints on maximum tissue temperature and thermal exposure of surrounding non-targeted tissue. This optimizationbased treatment planning and modeling system was applied on representative cases of clinical implants for HDR treatment of cervix and prostate to evaluate the utility of this planning approach. The planning provided significant improvement in achievable temperature distributions for all cases, with substantial increase in T90 and thermal dose (CEM43T90) coverage to the hyperthermia target volume while decreasing maximum treatment temperature and reducing thermal dose exposure to surrounding non-targeted tissues and thermally sensitive rectum and bladder. This optimization based treatment planning platform with catheter-based ultrasound applicators is a useful tool that has potential to significantly improve the delivery of hyperthermia in conjunction with HDR brachytherapy. The planning platform has been extended

  18. Brownfields Recommendations for Sustainable Site Design — Green Landscape Plan

    Science.gov (United States)

    The assessment of conditions contained in this report focuses on site-specific environmental and soil conditions that might affect recommendations related to sustainable landscaping and site design, stormwater management, and stormwater reuse.

  19. Site-specific design optimization of wind turbines

    DEFF Research Database (Denmark)

    Fuglsang, P.; Bak, C.; Schepers, J.G.

    2002-01-01

    This article reports results from a European project, where site characteristics were incorporated into the design process of wind turbines, to enable site-specific design. Two wind turbines of different concept were investigated at six different sites comprising normal flat terrain, offshore...... of a new wind turbine. Both annual energy yield and design-determining loads depended on site characteristics, and this represented a potential for site-specific design. The maximum variation in annual energy yield was 37% and the maximum variation in blade root fatigue loads was 62%. Optimized site...... advantage of high-wind-speed sites. It was not possible to design a single wind turbine for all wind climates investigated, since the differences in the design loads were too large. Multiple-site wind turbines should be designed for generic wind conditions, which cover wind parameters encountered at flat...

  20. 13th Forum for Specification and Design Languages (FDL) conference

    CERN Document Server

    Morawiec, Adam; System Specification and Design Languages : Selected Contributions from FDL 2010

    2012-01-01

    This book brings together a selection of the best papers from the thirteenth edition of the Forum on specification and Design Languages Conference (FDL), which was held in Southampton, UK in September 2010.  FDL is a well established international forum devoted to dissemination of research results, practical experiences and new ideas in the application of specification, design and verification languages to the design, modelling and verification of integrated circuits, complex hardware/software embedded systems, and mixed-technology systems. Covers design verification, automatic synthesis and mechanized debug aids; Includes language-based modeling and design techniques for embedded systems; Covers design, modeling and verification of mixed physical domain and mixed signal systems that include significant analog parts in electrical and non-electrical domains; Includes formal and semi-formal system level design methods for complex embedded systems based on the Unified Modelling Language (UML) and Model Driven E...

  1. Product service system product design task planning with supplier participation

    Directory of Open Access Journals (Sweden)

    Zhongqi Sheng

    2015-12-01

    Full Text Available Product service system is a new-type production system with high-degree integration and overall optimization of product and service. The participation of suppliers in product service system development will greatly shorten the development cycle and enhance the production efficiency. The task planning of product design is one of the key phases of product service system development process, which mainly contains the design task decomposition and the design task allocation. Aiming at product service system product design, this article conducts the decomposition of design tasks, performs the recognition of coupling design task set, and realizes the structured modeling of design tasks. Outsourcing decision-making analysis is conducted on the design tasks obtained through decomposition process so as to confirm the design tasks that need the participation of suppliers. The allocation model of design tasks is constructed, and the suppliers that take part in product service system development are confirmed based on genetic algorithm. Taking the numerical control machine tool as an example, this article conducts the instance analysis and verifies the feasibility of the forenamed methods.

  2. An optimisation model for the warehouse design and planning problem

    OpenAIRE

    Geraldes, Carla A. S.; Carvalho, Sameiro; Pereira, Guilherme

    2011-01-01

    In spite of the importance of warehouses in the field of the supply chain management, there is not a single decision model that integrates all the decisions that concerns the warehouse design and planning problem. A number of warehouse decision support models have been proposed in the literature but considerable difficulties in applying these models still remain, due to the large amount of information to be processed and to the large number of possible alternatives. In this paper we discuss a...

  3. The specifics of marketing in strategic planning of election campaigns in Ukraine

    Directory of Open Access Journals (Sweden)

    O. Y. Shinkarenko

    2015-06-01

    Full Text Available The article considers a number of issues related to common approaches to strategic planning of election campaigns and its specificity in the conditions of modern Ukraine. Examines the role of strategic planning in the process of organizing and conducting election campaigns, various types of strategies used. Provides information on the types of strategies that were used by Ukrainian political parties and blocs in the election period of 2014 to the Verkhovna Rada.In the article the analysis of some (the problem is very wide, to talk about the possibility completely to solve it within a short studies key aspects of strategic planning of election campaigns. And, on the other hand, examples of the use of such approaches in recent election campaigns to be implemented in Ukraine. Strategic planning of election campaigns stands as the most important aspect of their organization, which defines the content of the campaign, we have what you need to send a potential electorate to vote a certain way. The development strategy of the campaign is a necessary stage of its organization, requires the use of experienced creative professionals and a number of methods and technologies designed to achieve the desired candidate or political party participating in the election result. Distinguish the different types and varieties of election campaign strategies, which vary according to the type of elections, the resources, the order of candidates on the configuration of the election campaign, used substantive and technological approaches, as well as the rhythm of the implementation of the election campaign. Determined that in parliamentary elections in 2014, all parties entered the Parliament, including the Opposition bloc, has used various strategies that in some way determined their electoral success.

  4. Automated Design of Application-Specific Smart Camera Architectures

    NARCIS (Netherlands)

    Caarls, W.

    2008-01-01

    Parallel heterogeneous multiprocessor systems are often shunned in embedded system design, not only because of their design complexity but because of the programming burden. Programs for such systems are architecture-dependent: the application developer needs architecture-specific knowledge to imple

  5. Geographic specificity and positionality of public input in transportation: a rural transportation planning case from Central Texas

    Directory of Open Access Journals (Sweden)

    Greg P. Griffin

    2014-01-01

    Full Text Available Current transportation planning processes often incorporate public input, but the types of engagement techniques can affect the ability of practitioners to meaningfully include local ideas. This study incorporates literature integrating communicative rationality with participatory mapping, supported by a case study focusing on two public engagement techniques. A transportation planning process in Central Texas is evaluated in terms of the geographic specificity and positionality of comments received from open-ended responses on a questionnaire and a facilitated mapping session, and reviews this input for relevance to developing a transportation plan. Although all input received from the public can be valuable in the process, location-based comments may be more actionable by transportation planners. Participants’ perceived roles likely affect their level of engagement, which planners can facilitate to maximize the quality of involvement. Planners are advised to understand the positionality of project stakeholders and professionals, designing involvement methods considering geographic specificity appropriate for each project.

  6. Domain Specific Software Architecture for Design Center Automation

    CERN Document Server

    Sinha, Anshuman; Balakrishna, Vijaya

    2008-01-01

    Domain specific software architecture aims at software reuse through construction of domain architecture reference model. The constructed reference model presents a set of individual components and their interaction points. When starting on a new large software project, the design engineer starts with pre-constructed model, which can be easily browsed and picks up opportunities of use in the new solution design. This report discusses application of domain reference design methods by deriving domain specific reference architecture for a product ordering system in a design center. The product in this case is instock and special order blinds from different manufacturers in a large supply store. The development of mature domain specific reference software architecture for this domain is not the objective of this report. However, this report would like to capture the method used in one such process and that is the primary concern of this report. This report lists subjective details of such a process applied to the...

  7. Homolog-specific PCR primer design for profiling splice variants.

    Science.gov (United States)

    Srivastava, Gyan Prakash; Hanumappa, Mamatha; Kushwaha, Garima; Nguyen, Henry T; Xu, Dong

    2011-05-01

    To study functional diversity of proteins encoded from a single gene, it is important to distinguish the expression levels among the alternatively spliced variants. A variant-specific primer pair is required to amplify each alternatively spliced variant individually. For this purpose, we developed a new feature, homolog-specific primer design (HSPD), in our high-throughput primer and probe design software tool, PRIMEGENS-v2. The algorithm uses a de novo approach to design primers without any prior information of splice variants or close homologs for an input query sequence. It not only designs primer pairs but also finds potential isoforms and homologs of the input sequence. Efficiency of this algorithm was tested for several gene families in soybean. A total of 187 primer pairs were tested under five different abiotic stress conditions with three replications at three time points. Results indicate a high success rate of primer design. Some primer pairs designed were able to amplify all splice variants of a gene. Furthermore, by utilizing combinations within the same multiplex pool, we were able to uniquely amplify a specific variant or duplicate gene. Our method can also be used to design PCR primers to specifically amplify homologs in the same gene family. PRIMEGENS-v2 is available at: http://primegens.org.

  8. Robust Path Planning and Feedback Design Under Stochastic Uncertainty

    Science.gov (United States)

    Blackmore, Lars

    2008-01-01

    Autonomous vehicles require optimal path planning algorithms to achieve mission goals while avoiding obstacles and being robust to uncertainties. The uncertainties arise from exogenous disturbances, modeling errors, and sensor noise, which can be characterized via stochastic models. Previous work defined a notion of robustness in a stochastic setting by using the concept of chance constraints. This requires that mission constraint violation can occur with a probability less than a prescribed value.In this paper we describe a novel method for optimal chance constrained path planning with feedback design. The approach optimizes both the reference trajectory to be followed and the feedback controller used to reject uncertainty. Our method extends recent results in constrained control synthesis based on convex optimization to solve control problems with nonconvex constraints. This extension is essential for path planning problems, which inherently have nonconvex obstacle avoidance constraints. Unlike previous approaches to chance constrained path planning, the new approach optimizes the feedback gain as wellas the reference trajectory.The key idea is to couple a fast, nonconvex solver that does not take into account uncertainty, with existing robust approaches that apply only to convex feasible regions. By alternating between robust and nonrobust solutions, the new algorithm guarantees convergence to a global optimum. We apply the new method to an unmanned aircraft and show simulation results that demonstrate the efficacy of the approach.

  9. Robust Path Planning and Feedback Design Under Stochastic Uncertainty

    Science.gov (United States)

    Blackmore, Lars

    2008-01-01

    Autonomous vehicles require optimal path planning algorithms to achieve mission goals while avoiding obstacles and being robust to uncertainties. The uncertainties arise from exogenous disturbances, modeling errors, and sensor noise, which can be characterized via stochastic models. Previous work defined a notion of robustness in a stochastic setting by using the concept of chance constraints. This requires that mission constraint violation can occur with a probability less than a prescribed value.In this paper we describe a novel method for optimal chance constrained path planning with feedback design. The approach optimizes both the reference trajectory to be followed and the feedback controller used to reject uncertainty. Our method extends recent results in constrained control synthesis based on convex optimization to solve control problems with nonconvex constraints. This extension is essential for path planning problems, which inherently have nonconvex obstacle avoidance constraints. Unlike previous approaches to chance constrained path planning, the new approach optimizes the feedback gain as wellas the reference trajectory.The key idea is to couple a fast, nonconvex solver that does not take into account uncertainty, with existing robust approaches that apply only to convex feasible regions. By alternating between robust and nonrobust solutions, the new algorithm guarantees convergence to a global optimum. We apply the new method to an unmanned aircraft and show simulation results that demonstrate the efficacy of the approach.

  10. Mining Domain-Specific Design Patterns: A Case Study †

    Directory of Open Access Journals (Sweden)

    Vassiliki Gkantouna

    2017-02-01

    Full Text Available Domain-specific design patterns provide developers with proven solutions to common design problems that arise, particularly in a target application domain, facilitating them to produce quality designs in the domain contexts. However, research in this area is not mature and there are no techniques to support their detection. Towards this end, we propose a methodology which, when applied on a collection of websites in a specific domain, facilitates the automated identification of domain-specific design patterns. The methodology automatically extracts the conceptual models of the websites, which are subsequently analyzed in terms of all of the reusable design fragments used in them for supporting common domain functionalities. At the conceptual level, we consider these fragments as recurrent patterns consisting of a configuration of front-end interface components that interrelate each other and interact with end-users to support certain functionality. By performing a pattern-based analysis of the models, we locate the occurrences of all the recurrent patterns in the various website designs which are then evaluated towards their consistent use. The detected patterns can be used as building blocks in future designs, assisting developers to produce consistent and quality designs in the target domain. To support our case, we present a case study for the educational domain.

  11. Transportation Systems: Critical Infrastructure and Key Resources Sector-Specific Plan as Input to the National Infrastructure Protection Plan

    Science.gov (United States)

    2007-05-01

    Sector-Specific Plan To address the threat of a novel influenza virus with pandemic potential, the President, on November 1, 2005, announced the...Transportation Security SD Security Directive SIDA Security Identification Display Area SIPT Security Integrated Product Team SLFC State and Local Fusion

  12. Ethics, design and planning of the built environment

    CERN Document Server

    Moroni, Stefano

    2013-01-01

    The book proposes a set of original contributions in research areas shared by planning theory, architectural research, design and ethical inquiry. The contributors gathered in 2010 at the Ethics of the Built Environment seminar organized by the editors at Delft University of Technology. Both prominent and emerging scholars presented their researches in the areas of aesthetics, technological risks, planning theory and architecture. The scope of the seminar was highlighting shared lines of ethical inquiry among the themes discussed, in order to identify perspectives of innovative interdisciplinary research. After the seminar all seminar participants have elaborated their proposed contributions. Some of the most prominent international authors in the field were subsequently invited to join in with this inquiry. Claudia Basta teaches "Network Infrastructures and Mobility" at Wageningen University. Between 2009 and 2011 she worked as Coordinator of the 3TU Centre of Excellence for Ethics and Technology of Delft Un...

  13. A NEW METRIC APPROACH IN DESIGN PROCESS PLANNING

    Institute of Scientific and Technical Information of China (English)

    刘溪涓; 倪炎榕; 蒋寿伟

    2002-01-01

    Poor plans of design project are often caused by the difficulties in realizing the underlying complexities and immeasurable characteristics in the deisgn process. To overcome this diffculty, a metric approach based on the tasks analysis model of task importance degree was proposed. The model suggests that importance of a task can be measured through the influence to the project incurred by the imaginary failure of the task, which can be measured through three parts: the critical degree of a task to the whole project, the direct cost by the failure of a task, and the indirect cost on the other tasks affected by the failure of the task. The Analytic Hierarchy Process approach was applied to determine the critical degree and Case-based Reasoning idea was used in detecting the implied error in the task. As an application case, a review work planning was given and some conclusions were arrived at.

  14. Should I Be Following a Specific Diet or Nutrition Plan for My Lupus?

    Science.gov (United States)

    ... well with lupus Living well with lupus Should I be following a specific diet or nutrition plan ... a diet that will lower inflammation? What can I do about the weight gain from prednisone? Should ...

  15. Computer aided process planning and die design in simulation environment in sheet metal forming

    Science.gov (United States)

    Tisza, Miklós; Lukács, Zsolt

    2013-12-01

    During the recent 10-15 years, Computer Aided Process Planning and Die Design evolved as one of the most important engineering tools in sheet metal forming, particularly in the automotive industry. This emerging role is strongly emphasized by the rapid development of Finite Element Modeling, as well. The purpose of this paper is to give a general overview about the recent achievements in this very important field of sheet metal forming and to introduce some special results in this development activity. Therefore, in this paper, an integrated process simulation and die design system developed at the University of Miskolc, Department of Mechanical Engineering will be analyzed. The proposed integrated solutions have great practical importance to improve the global competitiveness of sheet metal forming in the very important segment of industry. The concept described in this paper may have specific value both for process planning and die design engineers.

  16. The San Luis Valley Project : Closed Basin Division : Design and planning of the project

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This design and planning document for the Closed Basin Division is a public information packet. The packet describes the planning process, design of the project,...

  17. Planning acetabular fracture reduction using patient-specific multibody simulation of the hip

    Science.gov (United States)

    Oliveri, Hadrien; Boudissa, Mehdi; Tonetti, Jerome; Chabanas, Matthieu

    2017-03-01

    Acetabular fractures are a challenge in orthopedic surgery. Computer-aided solutions were proposed to segment bone fragments, simulate the fracture reduction or design the osteosynthesis fixation plates. This paper addresses the simulation part, which is usually carried out by freely moving bone fragments with six degrees of freedom to reproduce the pre-fracture state. Instead we propose a different paradigm, closer to actual surgeon's requirements: to simulate the surgical procedure itself rather than the desired result. A simple, patient-specific, biomechanical multibody model is proposed, integrating the main ligaments and muscles of the hip joint while accounting for contacts between bone fragments. Main surgical tools and actions can be simulated, such as clamps, Schanz screws or traction of the femur. Simulations are computed interactively, which enables clinicians to evaluate different strategies for an optimal surgical planning. Six retrospective cases were studied, with simple and complex fracture patterns. After interactively building the models from preoperative CT, gestures from the surgical reports were reproduced. Results of the simulations could then be compared with postoperative CT data. A qualitative study shows the model behavior is excellent and the simulated reductions fit the observed data. A more quantitative analysis is currently being completed. Two cases are particularly significant, for which the surgical reduction actually failed. Simulations show it was indeed not possible to reduce these fractures with the chosen approach. Had our simulator being used, a better planning may have avoided a second surgery to these patients.

  18. Design specifications for manufacturability of MCM-C multichip modules

    Energy Technology Data Exchange (ETDEWEB)

    Allen, C.; Blazek, R.; Desch, J.; Elarton, J.; Kautz, D.; Markley, D.; Morgenstern, H.; Stewart, R.; Warner, L.

    1995-06-01

    The scope of this document is to establish design guidelines for electronic circuitry packaged as multichip modules of the ceramic substrate variety, although many of these guidelines are applicable to other types of multichip modules. The guidelines begin with prerequisite information which must be developed between customer and designer of the multichip module. The core of the guidelines focuses on the many considerations that must be addressed during the multichip module design. The guidelines conclude with the resulting deliverables from the design which satisfy customer requirements and/or support the multichip module fabrication and testing processes. Considerable supporting information, checklists, and design constraints are captured in specific appendices and used as reference information in the main body text. Finally some real examples of multichip module design are presented.

  19. Economic market design and planning for electric power systems

    CERN Document Server

    Mili, Lamine

    2010-01-01

    Discover cutting-edge developments in electric power systems. Stemming from cutting-edge research and education activities in the field of electric power systems, this book brings together the knowledge of a panel of experts in economics, the social sciences, and electric power systems. In ten concise and comprehensible chapters, the book provides unprecedented coverage of the operation, control, planning, and design of electric power systems. It also discusses:. A framework for interdisciplinary research and education;. Modeling electricity markets;. Alternative economic criteria and proactiv.

  20. Mechanism design and motion planning of M-Cubes robot

    Institute of Scientific and Technical Information of China (English)

    Xia Ping; Zhu Xinjian; Fei Yanqiong; Xu Bing

    2007-01-01

    A homogeneous and lattice self-reconfigurable robot module is designed, and each module is composed of a center body and six connection planes which can independently rotate. A module can independently connect or disconnect with other modules, and then change its connection by collaborating with other modules. We discuss how to describe and discover configuration of robot. Furthermore, we describe its motion planning based on the appraisal function and the adjacency matrix which is effective to solve the computationally difficult problem and optimize the system motion path during the self-reconfiguration process. Finally, a simulation experiment is demonstrated, which verifies the correctness of locomotion method.

  1. 40 CFR Appendix B to Subpart I of... - Allowance for Facilities Planning and Design

    Science.gov (United States)

    2010-07-01

    ... allowance under § 35.2025 for facilities planning and design. The Step 2+3, Step 3 and Step 7 grant... reimburse the grantee for costs actually incurred for facilities planning or design. Rather, the allowance... for Facilities Planning and Design Building cost Allowance as a percentage of building cost* $100,000...

  2. Robust Design of Reliability Test Plans Using Degradation Measures.

    Energy Technology Data Exchange (ETDEWEB)

    Lane, Jonathan Wesley; Lane, Jonathan Wesley; Crowder, Stephen V.; Crowder, Stephen V.

    2014-10-01

    With short production development times, there is an increased need to demonstrate product reliability relatively quickly with minimal testing. In such cases there may be few if any observed failures. Thus, it may be difficult to assess reliability using the traditional reliability test plans that measure only time (or cycles) to failure. For many components, degradation measures will contain important information about performance and reliability. These measures can be used to design a minimal test plan, in terms of number of units placed on test and duration of the test, necessary to demonstrate a reliability goal. Generally, the assumption is made that the error associated with a degradation measure follows a known distribution, usually normal, although in practice cases may arise where that assumption is not valid. In this paper, we examine such degradation measures, both simulated and real, and present non-parametric methods to demonstrate reliability and to develop reliability test plans for the future production of components with this form of degradation.

  3. Patient-specific independent 3D GammaPlan quality assurance for Gamma Knife Perfexion radiosurgery.

    Science.gov (United States)

    Mamalui-Hunter, Maria; Yaddanapudi, Sridhar; Zhao, Tianyu; Mutic, Sasa; Low, Daniel A; Drzymala, Robert E

    2013-01-07

    One of the most important aspects of quality assurance (QA) in radiation therapy is redundancy of patient treatment dose calculation. This work is focused on the patient-specific time and 3D dose treatment plan verification for stereotactic radiosurgery using Leksell Gamma Knife Perfexion (LGK PFX). The virtual model of LGK PFX was developed in MATLAB, based on the physical dimensions provided by the manufacturer. The ring-specific linear attenuation coefficients (LAC) and output factors (OFs) reported by the manufacturer were replaced by the measurement-based collimator size-specific OFs and a single LAC = 0.0065 mm-1. Calculation depths for each LGK PFX shot were obtained by ray-tracing technique, and the dose calculation formalism was similar to the one used by GammaPlan treatment planning software versions 8 and 9. The architecture of the QA process was based on the in-house online database search of the LGK PFX database search for plan-specific information. A series of QA phantom plans was examined to verify geometric and dosimetric accuracy of the software. The accuracy of the QA process was further evaluated through evaluation of a series of patient plans. The shot time/focus point dose verification for each shot took less than 1 sec/shot with full 3D isodose verification taking about 30 sec/shot on a desktop PC. GammaPlan database access time took less than 0.05 sec. The geometric accuracy (location of the point of maximum dose) of the phantom and patient plan was dependent on the resolution of the original dose matrix and was of the order of 1 dose element. Dosimetric accuracy of the independently calculated phantom and patient point (focus) doses was within 3.5% from the GammaPlan, with the mean = 2.3% and SD= 1.1%. The process for independent pretreatment patient-specific Gamma Knife Perfexion time and dose verification was created and validated.

  4. Specification, Design, and Analysis of Advanced HUMS Architectures

    Science.gov (United States)

    Mukkamala, Ravi

    2004-01-01

    During the two-year project period, we have worked on several aspects of domain-specific architectures for HUMS. In particular, we looked at using scenario-based approach for the design and designed a language for describing such architectures. The language is now being used in all aspects of our HUMS design. In particular, we have made contributions in the following areas. 1) We have employed scenarios in the development of HUMS in three main areas. They are: (a) To improve reusability by using scenarios as a library indexing tool and as a domain analysis tool; (b) To improve maintainability by recording design rationales from two perspectives - problem domain and solution domain; (c) To evaluate the software architecture. 2) We have defined a new architectural language called HADL or HUMS Architectural Definition Language. It is a customized version of xArch/xADL. It is based on XML and, hence, is easily portable from domain to domain, application to application, and machine to machine. Specifications written in HADL can be easily read and parsed using the currently available XML parsers. Thus, there is no need to develop a plethora of software to support HADL. 3) We have developed an automated design process that involves two main techniques: (a) Selection of solutions from a large space of designs; (b) Synthesis of designs. However, the automation process is not an absolute Artificial Intelligence (AI) approach though it uses a knowledge-based system that epitomizes a specific HUMS domain. The process uses a database of solutions as an aid to solve the problems rather than creating a new design in the literal sense. Since searching is adopted as the main technique, the challenges involved are: (a) To minimize the effort in searching the database where a very large number of possibilities exist; (b) To develop representations that could conveniently allow us to depict design knowledge evolved over many years; (c) To capture the required information that aid the

  5. Specification, Design, and Analysis of Advanced HUMS Architectures

    Science.gov (United States)

    Mukkamala, Ravi

    2004-01-01

    During the two-year project period, we have worked on several aspects of domain-specific architectures for HUMS. In particular, we looked at using scenario-based approach for the design and designed a language for describing such architectures. The language is now being used in all aspects of our HUMS design. In particular, we have made contributions in the following areas. 1) We have employed scenarios in the development of HUMS in three main areas. They are: (a) To improve reusability by using scenarios as a library indexing tool and as a domain analysis tool; (b) To improve maintainability by recording design rationales from two perspectives - problem domain and solution domain; (c) To evaluate the software architecture. 2) We have defined a new architectural language called HADL or HUMS Architectural Definition Language. It is a customized version of xArch/xADL. It is based on XML and, hence, is easily portable from domain to domain, application to application, and machine to machine. Specifications written in HADL can be easily read and parsed using the currently available XML parsers. Thus, there is no need to develop a plethora of software to support HADL. 3) We have developed an automated design process that involves two main techniques: (a) Selection of solutions from a large space of designs; (b) Synthesis of designs. However, the automation process is not an absolute Artificial Intelligence (AI) approach though it uses a knowledge-based system that epitomizes a specific HUMS domain. The process uses a database of solutions as an aid to solve the problems rather than creating a new design in the literal sense. Since searching is adopted as the main technique, the challenges involved are: (a) To minimize the effort in searching the database where a very large number of possibilities exist; (b) To develop representations that could conveniently allow us to depict design knowledge evolved over many years; (c) To capture the required information that aid the

  6. 7 CFR 1753.7 - Plans and specifications (P&S).

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 11 2010-01-01 2010-01-01 false Plans and specifications (P&S). 1753.7 Section 1753.7... specifications (P&S). (a) The P&S consist of an RUS contract form, the appropriate RUS specifications, and such... standards and specifications listed in 7 CFR part 1755 shall be included in the P&S. When RUS has...

  7. The design of a low specific fuel consumption turbocompound engine

    Energy Technology Data Exchange (ETDEWEB)

    Wilson, D.E.

    1986-01-01

    Continued emphasis has been placed on reducing the specific fuel consumption (sfc) of heavy-duty diesel engines. Through design improvements, engines with sfc levels of 200 g/kW-hr are now reaching the consumer. With the addition of turbocompounding, sfc can be reduced below 185 g/kW-hr. This paper describes the concept, design, and initial performance test of an 11.3 liter, 6 cylinder non-insulated turbocompound engine. Improvements in the turbocharged engine design resulted in a rated sfc of 192 g/kW-hr. The turbocompound engine demonstrated an sfc of 182 g/kW-hr at the same rating.

  8. Overview of energy-conserving development planning and design techniques based on five case studies

    Energy Technology Data Exchange (ETDEWEB)

    1980-06-01

    Findings and recommendations are presented of a review of five case studies of ways to conserve energy through development planning and site design in communities. Two approaches were used. In the first approach, a conventional, pre-existing plan was analyzed to determine potential energy use. Once energy-conservation options were identified and evaluated, the conventional plan was modified by employing those options. This approach was used in The Woodlands, Burke Center, and Radisson studies. In the second approach, energy-conservation options are independently identified and evaluated. Those options that passed specific criteria screening were then utilized in developing one or more totally new plans based on energy objectives. This approach was used in Greenbrier and Shenandoah. Radisson is a new town on the outskirts of Syracuse, New York. Greenbrier is a 3000 acre planned community adjacent to Norfolk and Virginia Beach. Shenandoah is a proposed new town in the Atlanta urbanized area. The Woodlands is a new community under development north of Houston. Burke Center is a residential planned unit development in Fairfax County, Virgnia. (MCW)

  9. Specific PCR product primer design using memetic algorithm.

    Science.gov (United States)

    Yang, Cheng-Hong; Cheng, Yu-Huei; Chuang, Li-Yeh; Chang, Hsueh-Wei

    2009-01-01

    To provide feasible primer sets for performing a polymerase chain reaction (PCR) experiment, many primer design methods have been proposed. However, the majority of these methods require a relatively long time to obtain an optimal solution since large quantities of template DNA need to be analyzed. Furthermore, the designed primer sets usually do not provide a specific PCR product size. In recent years, evolutionary computation has been applied to PCR primer design and yielded promising results. In this article, a memetic algorithm (MA) is proposed to solve primer design problems associated with providing a specific product size for PCR experiments. The MA is compared with a genetic algorithm (GA) using an accuracy formula to estimate the quality of the primer design and test the running time. Overall, 50 accession nucleotide sequences were sampled for the comparison of the accuracy of the GA and MA for primer design. Five hundred runs of the GA and MA primer design were performed with PCR product lengths of 150-300 bps and 500-800 bps, and two different methods of calculating T(m) for each accession nucleotide sequence were tested. A comparison of the accuracy results for the GA and MA primer design showed that the MA primer design yielded better results than the GA primer design. The results further indicate that the proposed method finds optimal or near-optimal primer sets and effective PCR products in a dry dock experiment. Related materials are available online at http://bio.kuas.edu.tw/ma-pd/. 2009 American Institute of Chemical Engineers

  10. Systematic design of mouse Vh gene family-specific oligonucleotides

    NARCIS (Netherlands)

    Seijen, AM; Seijen, HG; Bos, NA

    2001-01-01

    Kabat's database has often been used to design mouse Vh gene-specific 5 ' primers. The emphasis was mostly on constructing a universal (degenerate) 5 ' primer or 5 ' primer set, which would be able to match every mouse Vh gene. We were interested in finding oligonucleotides that could be used as pri

  11. 46 CFR 162.050-25 - Cargo monitor: Design specification.

    Science.gov (United States)

    2010-10-01

    ..., AND MATERIALS: SPECIFICATIONS AND APPROVAL ENGINEERING EQUIPMENT Pollution Prevention Equipment § 162... cause formation of static electricity. (e) A monitor must be designed to operate in each plane that forms an angle of 22.5° with the plane of its normal operating position. (f) Each monitor must...

  12. Application software, domain-specific languages, and language design assistants

    NARCIS (Netherlands)

    J. Heering (Jan)

    2000-01-01

    textabstractWhile application software does the real work, domain-specific languages (DSLs) are tools to help produce it efficiently, and language design assistants in turn are meta-tools to help produce DSLs quickly. DSLs are already in wide use (HTML for web pages, Excel macros for spreadsheet

  13. Domain-specific language design requires feature descriptions

    NARCIS (Netherlands)

    A. van Deursen (Arie); P. Klint (Paul)

    2001-01-01

    textabstractA domain-specific language (DSL) provides a notation tailored towards an application domain and is based on the relevant concepts and features of that domain. As such, a DSL is a means to describe and generate members of a family of programs in the domain. A prerequisite for the design

  14. Baseline design of an OTEC pilot plantship. Volume C. Specifications

    Energy Technology Data Exchange (ETDEWEB)

    Glosten, L. R.; Bringloe, Thomas; Soracco, Dave; Fenstermacher, Earl; Magura, Donald; Sander, Olof; Richards, Dennis; Seward, Jerry

    1979-05-01

    Volume C is part of a three-volume report that presents a baseline engineering design of an Ocean Thermal Energy Conversion (OTEC) plantship. This volume provides the specifications for the hull, cold-water pipe, ship outfitting and machinery, OTEC power system, electrical system, and folded-tube heat exchangers.

  15. Systematic design of mouse Vh gene family-specific oligonucleotides

    NARCIS (Netherlands)

    Seijen, AM; Seijen, HG; Bos, NA

    2001-01-01

    Kabat's database has often been used to design mouse Vh gene-specific 5 ' primers. The emphasis was mostly on constructing a universal (degenerate) 5 ' primer or 5 ' primer set, which would be able to match every mouse Vh gene. We were interested in finding oligonucleotides that could be used as pri

  16. A design guide and specification for small explosive containment structures

    Energy Technology Data Exchange (ETDEWEB)

    Marchand, K.A.; Cox, P.A.; Polcyn, M.A. [Southwest Research Institute, San Antonio, TX (United States)

    1994-12-01

    The design of structural containments for testing small explosive devices requires the designer to consider the various aspects of the explosive loading, i.e., shock and gas or quasistatic pressure. Additionally, if the explosive charge has the potential of producing damaging fragments, provisions must be made to arrest the fragments. This may require that the explosive be packed in a fragment attenuating material, which also will affect the loads predicted for containment response. Material also may be added just to attenuate shock, in the absence of fragments. Three charge weights are used in the design. The actual charge is used to determine a design fragment. Blast loads are determined for a {open_quotes}design charge{close_quotes}, defined as 125% of the operational charge in the explosive device. No yielding is permitted at the design charge weight. Blast loads are also determined for an over-charge, defined as 200% of the operational charge in the explosive device. Yielding, but no failure, is permitted at this over-charge. This guide emphasizes the calculation of loads and fragments for which the containment must be designed. The designer has the option of using simplified or complex design-analysis methods. Examples in the guide use readily available single degree-of-freedom (sdof) methods, plus static methods for equivalent dynamic loads. These are the common methods for blast resistant design. Some discussion of more complex methods is included. Generally, the designer who chooses more complex methods must be fully knowledgeable in their use and limitations. Finally, newly fabricated containments initially must be proof tested to 125% of the operational load and then inspected at regular intervals. This specification provides guidance for design, proof testing, and inspection of small explosive containment structures.

  17. Pilot test specific test plan for the removal of arsenic Socorro, New Mexico.

    Energy Technology Data Exchange (ETDEWEB)

    Collins, Sue S.; Aragon, Malynda Jo; Everett, Randy L.; Siegel, Malcolm Dean; Aragon, Alicia R.; Dwyer, Brian P.; Marbury, Justin Luke

    2006-03-01

    Sandia National Laboratories (SNL) is conducting pilot scale evaluations of the performance and cost of innovative drinking water treatment technologies designed to meet the new arsenic maximum contaminant level (MCL) of 10 {micro}g/L (effective January 2006). As currently envisioned, pilots tests may include multiple phases. Phase I tests will involve side-by-side comparisons of several commercial technologies primarily using design parameters suggested by the Vendors. Subsequent tests (Phase II) may involve repeating some of the original tests, testing the same commercial technologies under different conditions and testing experimental technologies or additional commercial technologies. This Pilot Test Specific Test Plan (PTSTP) was written for Phase I of the Socorro Springs Pilot. The objectives of Phase I include evaluation of the treatment performance of five adsorptive media under ambient pH conditions (approximately 8.0) and assessment of the effect of contact time on the performance of one of the media. Addenda to the PTSTP may be written to cover Phase II studies and supporting laboratory studies. The Phase I demonstration began in the winter of 2004 and will last approximately 9 months. The information from the test will help the City of Socorro choose the best arsenic treatment technology for the Socorro Springs well. The pilot demonstration is a project of the Arsenic Water Technology Partnership program, a partnership between the American Water Works Association (AWWA) Research Foundation, SNL, and WERC (A Consortium for Environmental Education and Technology Development).

  18. Incorporating Age-Specific Plans of Care to Achieve Optimal Perioperative Outcomes.

    Science.gov (United States)

    Mower, Juliana

    2015-10-01

    When developing a nursing plan of care, a perioperative nurse identifies nursing diagnoses during the preoperative patient assessment. The ability to identify age-specific outcomes (ie, infant/child, adolescent, adult, elderly adult) in addition to those that are universally applicable is a major responsibility of the perioperative RN. Having an individualized plan of care is one of the best ways to determine whether desired patient outcomes have been successfully attained. Nursing care plans address intraoperative and postoperative risks and allow for a smooth transfer of care throughout the perioperative experience. A good nursing care plan also includes education for the patient and his or her caregiver. Within an overall plan of care, the use of methods such as a concept or mind map can visually demonstrate the relationships between systems, nursing diagnoses, nursing interventions, and desirable outcomes.

  19. Spatial Planning as a Design Discipline: A Paradigm for Western Europe?

    NARCIS (Netherlands)

    Needham, D.B.

    2000-01-01

    There is an implicit paradigm in the theory of spatial planning, which we call `spatial planning as a design discipline'. It is implicit in much of planning theory, and the exposition here is in many respects an ordering of ideas from planning theory which have been in circulation for many years.

  20. Reliability and Factorial Validity of Non-Specific and Tennis-Specific Pre-Planned Agility Tests; Preliminary Analysis

    Science.gov (United States)

    Sekulic, Damir; Uljevic, Ognjen; Peric, Mia; Spasic, Miodrag; Kondric, Miran

    2017-01-01

    Abstract Agility is an important quality in tennis, yet there is an evident lack of studies focussing on the applicability of tennis-specific agility performances and comparing them to equivalent non-specific agility performances. The aim of this study was to evaluate the reliability and factorial validity of three tests of pre-planned agility, performed in specific (with a tennis racquet) and non-specific (without a tennis racquet) conditions. The sample consisted of 33 tennis players (13 males and 20 females; age: 18.3 ± 1.1 years and 18.6 ± 1.3 years; body height: 185.4 ± 51 cm and 169.3 ± 4.2 cm, 74.0 ± 4.4 kg and 61.2 ± 3.1 kg, respectively). The variables comprised three agility tests: a 20-yard test, a T-test and the Illinois test, all performed in both specific and non-specific conditions. Between-subject and within-subject reliability were found to be high (Cronbach Alpha: 0.93 to 0.98; Coefficient of Variation: 3 to 8%), with better within-subject reliability and stability of the measurement for specific tests. Pearson’s product moment correlations between the non-specific and specific agility performances were high (r ≥0.84), while factor analysis extracted only one significant latent dimension on the basis of the Guttman-Kaiser criterion. The results of the 20-yard test were better when the test was conducted in the specific conditions (t-test = 2.66; p test, superior results were recorded in the non-specific conditions (t-test = 2.96; p test duration (about 20 s) and non-specific locomotion forms such as rotational movements. Considering the findings of the present study, when testing tennis-specific pre-planned agility, we suggest using tests of short duration (less than 10 s) and sport-specific types of locomotion. PMID:28210343

  1. Designing Star Quality S.O.S. Lesson Plans. Tips

    Science.gov (United States)

    Small, Ruth V.

    2007-01-01

    Once a lesson plan has been submitted to S.O.S., it goes to two independent evaluators, who review every part of the plan, from the title to related standards, using a common rubric. Each section of the lesson plan is rated as either Acceptable, Needs Improvement, or Unacceptable. The collective ratings of all sections of the lesson plan are then…

  2. Specific issues of the design for the elderly

    Science.gov (United States)

    Sebesi, S. B.; Groza, H. L.; Ianoşi, A.; Dimitrova, A.; Mândru, D.

    2016-08-01

    The actual demographic studies show that number of the elderly people is increasing constantly. Considering their motor, sensorial and cognitive constrains and restrictions, a new field of Assistive Technology is developing, focussed on the design and development of a wide range of devices, apparatus, equipment and systems dedicated to their independent and safe life. In this paper, a systematisation of existing gero-technical systems is proposed, emphasising the today trends in this field. The specific issues of designing this kind of products are identified and analysed. Two approaches of the authors are finally presented: wearable suits for aging and disabilities simulation and tele-monitoring of the elderly.

  3. Preoperative planning and designing of a fluorocompatible endourology operating room.

    Science.gov (United States)

    Sabnis, Ravindra B; Mishra, Shashikant; Sharma, Rajan; Desai, Mahesh R

    2009-10-01

    A dedicated fluoroscopic-compatible operating room (OR) for endourologic procedures, such as percutaneous nephrolithotomy and ureteroscopy, is structurally and functionally different from the general OR. Publications with practical details are scarce, imposing a challenge in construction of such an OR. We outline a practical approach for the design and construction of a modern flourocompatible endourology OR. There were no publications related to a dedicated endourology OR in Medline. A search was then performed for English language articles on OR designing, fluoroscopy in the OR, data archiving, and data relay. We also surveyed the existing endourology OR in different hospitals and analyzed the available technology for audiovisual capture and relay in surgery. This article was then prepared, covering the relevant areas on designing a dedicated flourocompatible endourology OR. Close cooperation and interaction between an architect and expert construction manager for designing, development, and construction of an OR are necessary. Strategic equipment placement with booms is essential to increase the efficiency and safety within the surgical space. Distinct features of an endourology OR are thickness of the walls for radiation protection, wide OR gate, central floor water exit drain, flourocompatible rotatable OR table, C-arm unit, minimum three hanging thin-film transistor (TFT) screen monitors, and endoscopic equipment supported on a boom. The anesthetic boom should be retractable and movable from one end of the OR table to other. The OR should have an electronic workstation strategically located at one corner for data capture, archiving, and telementoring. Data relay of the OR procedure is facilitated by a control room located in the vicinity of the OR. Designing the layout of the OR is extremely important, necessitating thoughtful planning to provide hassle-free movement, comfort to the surgeon, and efficient data archiving and transmission during a surgical

  4. 7 CFR 1724.54 - Requirements for RUS approval of plans and specifications.

    Science.gov (United States)

    2010-01-01

    ... specifications for transmission construction projects which are not based on RUS approved line design data or do... building design meets the Uniform Federal Accessibility Standards (See § 1724.51(e)(1)(i)). (g... DESIGN POLICIES AND PROCEDURES Electric System Design § 1724.54 Requirements for RUS approval of...

  5. Transfer cask system design activities: status and plan

    Energy Technology Data Exchange (ETDEWEB)

    Locke, D., E-mail: darren.locke@f4e.europa.eu [Fusion for Energy Agency (F4E), Torres Diagonal Litoral B3, Josep Pla 2, 08019 Barcelona (Spain); Gutierrez, C. Gonzalez; Damiani, C.; Gracia, V. [Fusion for Energy Agency (F4E), Torres Diagonal Litoral B3, Josep Pla 2, 08019 Barcelona (Spain); Friconneau, J.-P.; Martins, J.-P.; Blight, J. [ITER Organisation, CS 90 046, 13067St. Paul Lez Durance Cedex (France)

    2011-10-15

    The ITER Cask and Plug Remote Handling System (CPRHS), a.k.a. Transfer Cask System, is a critical element of the ITER Remote Maintenance System (IRMS) devoted to transportation of components between the Tokamak building and Hot Cell. Due to the necessary confinement of contaminated components the CPRHS is defined as Safety Importance Class 1 (SIC-1) plus the mobile nature of the CPRHS brings with it a significant number of complex interfaces with other ITER sub-systems. With a total CPRHS fleet in excess of 20 units, including seven typologies, the management of design and procurement needs to be carefully planned and implemented to ensure compliance with ITER's requirements. Fusion for Energy (F4E) and its beneficiaries/contractors are currently working under ITER Task Agreements (ITAs) on the conceptual design of the CPRHS and, following the signing of the Procurement Arrangement (PA) in mid 2012, will take responsibility for the entire CPRHS fleet. F4E must, therefore, develop a robust strategy to meet the needs of both ITER machine assembly (for which a number of CPRHS units will be utilised) and the remote maintenance of ITER. Within this context this paper will present the status of the current CPRHS design activities, highlight some of the significant issues which will be faced during procurement and present the overall strategy which is being implemented by F4E in order to meet these challenging objectives.

  6. Rationale and Design of the Access Specification Language RASP

    Directory of Open Access Journals (Sweden)

    Mark Evered

    2014-05-01

    Full Text Available In this paper we describe the formal specification language RASP for expressing fine-grained access control constraints in information systems. The design of the language is motivated by a number of IS case studies which demonstrate the complexity of the access constraints which arise if minimal (need-to-know access is to be strictly enforced. RASP supports modularity, parameterization, role acquisition, constraint expressions and a symmetrical approach to role transitions and attribute transitions. No existing access control specification language supports all of these complex, realistic requirements.

  7. Environmental restoration and waste management site-specific plan for Richland Operations Office. [Contains glossary

    Energy Technology Data Exchange (ETDEWEB)

    1991-09-01

    This document was prepared to implement and support the US Department of Energy-Headquarters (DOE-HQ) national plan. The national plan, entitled Environmental Restoration and Waste Management Five-Year Plan (DOE 1990b) (hereinafter referred to as the DOE-HQ Five-Year Plan) is the cornerstone of the US Department of Energy's (DOE) long-term strategy in environmental restoration and waste management. The DOE-HQ Five-Year Plan addresses overall philosophy and environmental and waste-related activities under the responsibilities of the DOE Office of Environmental Restoration and Waste Management. The plan also reaffirms DOE-HQ goals to bring its nuclear sites into environmental compliance in cooperation with its regulators and the public, and to clean up and restore the environment by 2019 (the commitment for the Hanford Site is for one year sooner, or 2018). This document is part of the site-specific plan for the US Department of Energy-Richland Operations Office (DOE-RL). It is the first revision of the original plan, which was dated December 1989 (DOE-RL 1989a). This document is a companion document to the Overview of the Hanford Cleanup Five-Year Plan (DOE-RL 1989d) and The Hanford Site Environmental Restoration and Waste Management Five-Year Plan Activity Data Sheets (DOE-RL 1991). Although there are three documents that make up the complete DOE-RL plan, this detailed information volume was prepared so it could be used as a standalone document. 71 refs., 40 figs., 28 tabs.

  8. Simulated Prosthesis Overlay for Patient-Specific Planning of Transcatheter Aortic Valve Implantation Procedures.

    Science.gov (United States)

    Sündermann, Simon H; Gessat, Michael; Maier, Willibald; Kempfert, Jörg; Frauenfelder, Thomas; Nguyen, Thi D L; Maisano, Francesco; Falk, Volkmar

    2015-01-01

    We tested the hypothesis that simulated three-dimensional prosthesis overlay procedure planning may support valve selection in transcatheter aortic valve implantation (TAVI) procedures. Preoperative multidimensional computed tomography (MDCT) data sets from 81 consecutive TAVI patients were included in the study. A planning tool was developed, which semiautomatically creates a three-dimensional model of the aortic root from these data. Three-dimensional templates of the commonly used TAVI implants are spatially registered with the patient data and presented as graphic overlay. Fourteen physicians used the tool to perform retrospective planning of TAVI procedures. Results of prosthesis sizing were compared with the prosthesis size used in the actually performed procedure, and the patients were accordingly divided into three groups: those with equal size (concordance with retrospective planning), oversizing (retrospective planning of a smaller prosthesis), and undersizing (retrospective planning of a larger prosthesis). In the oversizing group, 85% of the patients had new pacemaker implantation. In the undersizing group, in 66%, at least mild paravalvular leakage was observed (greater than grade 1 in one third of the cases). In 46% of the patients in the equal-size group, neither of these complications was observed. Three-dimensional prosthesis overlay in MDCT-derived patient data for patient-specific planning of TAVI procedures is feasible. It may improve valve selection compared with two-dimensional MDCT planning and thus yield better outcomes.

  9. NATO Conference on Manpower Planning and Organization Design

    CERN Document Server

    Niehaus, Richard

    1978-01-01

    This volume is the proceedings of the conference entitled "Manpower Planning and Organization Design" which was held in Stresa, Italy, 20-24 June 1977. The Conference was sponsored by the NATO Scientific Affairs Division and organized jointly through the Special Programs Panels on Human Factors and on Systems Science. Two Conference Directors were appointed with overall responsibilities for the programme and for policy, and they were assisted in their tasks by a small advisory panel consisting of Professor A. Charnes (University of Texas), Professor W.W. Cooper (Carnegie Mellon University, now at Harvard University) and Dr. F.A. Heller (TavistQck Institute of Human Relations). Professor R. Florio of Bergamo kindly agreed to become Administrative Director and, as such, was responsible for all the local arrangements. The Conference Directors were further assisted by "national points of contact" appointed from each of the member countries of NATO. These national representatives played a substantial part in the s...

  10. Sustainable green inner-wall design for flexible floor plan

    Science.gov (United States)

    Tawil, N. M.; Husaini, H. A.; Ani, A. I.; Basri, H.; Saleh, R. M.

    2013-06-01

    The rises of house price in the market is so drastic that it effects the younger generation nowadays especially young executives and young couples who could not afford to buy their first home. The factors that determine the house price presumably are the interior and exterior structural of the house itself. So to lessen the house price, we have to minimize the usage of wet construction thus the idea of having a sustainable green inner-wall implemented into the house with a flexible floor plan. This concept is user-friendly as it is built on needs and the ownership's affordability. They can design the interior of the house however they want with using minimal cost because it does not involve wet construction.

  11. Current trends in health facility planning, design, and construction.

    Science.gov (United States)

    Beale, Craig; Kittredge, Frank D

    2014-01-01

    It is critical now more than ever for today's healthcare facilities to serve as more than just a backdrop to the care provided--they can, and should, be an integral part of that care. In addition to promoting efficacy, delighting the senses, and placing patients and families at ease, facilities need to be high-performing, sustainable, and healthy environments. Creating today's healthcare facilities requires breaking through barriers in unexpected ways, and it often requires looking outside the healthcare profession for guidance. In this article, we explore current trends in health facility planning, design, and construction. Our focus is on the buildings that serve as venues for the provision of healthcare services across the full continuum, from prevention to critical care. In particular, we discuss four current broad trends and conclude with thoughts on future developments.

  12. Sustainable winter cities: Future directions for planning, policy and design

    Science.gov (United States)

    Pressman, Norman E. P.

    Attempts to generate a "climate-responsive" northern urban form are part of a relatively recent phenomenon and field of investigation. In conjunction with the international "winter cities" movement, the need has been established for explicit, systematic inquiry directed toward national and local action to improve the comfort and lifestyles of all northern inhabitants. It is important to recognize that winter-induced discomforts exist and that they must be acknowledged in planning theory and practice. For northern cities to function more satisfactorily, the negative impacts of winter must be reduced while its beneficial characteristics are enhanced. While not all summer activities can or should be abandoned during winter, proper micro-climatic control is essential if human life is to be retained outside. The outdoor season should be extended since so much indoor isolation occurs. The main principles to be incorporated in exemplary "winter city" design should be contact with nature, year-round usability, user participation, cultural continuity, and the creation of comfortable micro-climatic conditions throughout much of the city's open spaces. All valuable sources of inspiration must be harnessed in the attempt to mediate between organic regionalism and internationalism, on the one hand, and romanticism and pragmatic realism, on the other. Creating optimum conditions for human well-being, habitation, work and intellectual development in each of the four seasons is vital under harsh environments. Adopting a climate-sensitive approach to planning policy and urban design can render everyday life less stressful, especially during the lengthy winter periods found in many northern latitude and high altitude settings.

  13. Constructing a modern cytology laboratory: A toolkit for planning and design.

    Science.gov (United States)

    Roberson, Janie; Wrenn, Allison; Poole, John; Jaeger, Andrew; Eltoum, Isam A

    2013-01-01

    Constructing or renovating a laboratory can be both challenging and rewarding. UAB Cytology (UAB CY) recently undertook a project to relocate from a building constructed in 1928 to new space. UAB CY is part of an academic center that provides service to a large set of patients, support training of one cytotechnology program and one cytopathology fellowship training program and involve actively in research and scholarly activity. Our objectives were to provide a safe, aesthetically pleasing space and gain efficiencies through lean processes. The phases of any laboratory design project are Planning, Schematic Design (SD), Design Development (DD), Construction Documents (CD) and Construction. Lab personnel are most critical in the Planning phase. During this time stakeholders, relationships, budget, square footage and equipment were identified. Equipment lists, including what would be relocated, purchased new and projected for future growth ensure that utilities were matched to expected need. A chemical inventory was prepared and adequate storage space was planned. Regulatory and safety requirements were discussed. Tours and high level process flow diagrams helped architects and engineers understand the laboratory daily work. Future needs were addressed through a questionnaire which identified potential areas of growth and technological change. Throughout the project, decisions were driven by data from the planning phase. During the SD phase, objective information from the first phase was used by architects and planners to create a general floor plan. This was the basis of a series of meetings to brainstorm and suggest modifications. DD brings more detail to the plans with engineering, casework, equipment specifics, finishes. Design changes should be completed at this phase. The next phase, CD took the project from the lab purview into purely technical mode. Construction documents were used by the contractor for the bidding process and ultimately the Construction

  14. Constructing a modern cytology laboratory: A toolkit for planning and design

    Directory of Open Access Journals (Sweden)

    Janie Roberson

    2013-01-01

    Full Text Available Introduction: Constructing or renovating a laboratory can be both challenging and rewarding. UAB Cytology (UAB CY recently undertook a project to relocate from a building constructed in 1928 to new space. UAB CY is part of an academic center that provides service to a large set of patients, support training of one cytotechnology program and one cytopathology fellowship training program and involve actively in research and scholarly activity. Our objectives were to provide a safe, aesthetically pleasing space and gain efficiencies through lean processes. Methods: The phases of any laboratory design project are Planning, Schematic Design (SD, Design Development (DD, Construction Documents (CD and Construction. Lab personnel are most critical in the Planning phase. During this time stakeholders, relationships, budget, square footage and equipment were identified. Equipment lists, including what would be relocated, purchased new and projected for future growth ensure that utilities were matched to expected need. A chemical inventory was prepared and adequate storage space was planned. Regulatory and safety requirements were discussed. Tours and high level process flow diagrams helped architects and engineers understand the laboratory daily work. Future needs were addressed through a questionnaire which identified potential areas of growth and technological change. Throughout the project, decisions were driven by data from the planning phase. During the SD phase, objective information from the first phase was used by architects and planners to create a general floor plan. This was the basis of a series of meetings to brainstorm and suggest modifications. DD brings more detail to the plans with engineering, casework, equipment specifics, finishes. Design changes should be completed at this phase. The next phase, CD took the project from the lab purview into purely technical mode. Construction documents were used by the contractor for the bidding

  15. Environmental restoration and waste management Site-Specific Plan for the Oak Ridge Reservation. FY 1993

    Energy Technology Data Exchange (ETDEWEB)

    1993-01-15

    The United States Department of Energy (DOE) is committed to achieving and maintaining environmental regulatory compliance while responding to public concerns and emphasizing waste minimization. DOE publishes the Environmental Restoration and Waste Management Five-Year Plan (FYP) annually to document its progress towards these goals. The purpose of this Site-Specific Plan (SSP) is to describe the activities undertaken to implement the FYP goals at the DOE Oak Ridge Field Office (DOE/OR) installations and programs specifically for the Oak Ridge Reservation (ORR) and surrounding areas. This SSP addresses activities and goals to be accomplished during FY93 even through the FYP focuses on FY94.

  16. Transforming Multidisciplinary Customer Requirements to Product Design Specifications

    Science.gov (United States)

    Ma, Xiao-Jie; Ding, Guo-Fu; Qin, Sheng-Feng; Li, Rong; Yan, Kai-Yin; Xiao, Shou-Ne; Yang, Guang-Wu

    2017-09-01

    With the increasing of complexity of complex mechatronic products, it is necessary to involve multidisciplinary design teams, thus, the traditional customer requirements modeling for a single discipline team becomes difficult to be applied in a multidisciplinary team and project since team members with various disciplinary backgrounds may have different interpretations of the customers' requirements. A new synthesized multidisciplinary customer requirements modeling method is provided for obtaining and describing the common understanding of customer requirements (CRs) and more importantly transferring them into a detailed and accurate product design specifications (PDS) to interact with different team members effectively. A case study of designing a high speed train verifies the rationality and feasibility of the proposed multidisciplinary requirement modeling method for complex mechatronic product development. This proposed research offersthe instruction to realize the customer-driven personalized customization of complex mechatronic product.

  17. On Design and Implementation of the Distributed Modular Audio Recognition Framework: Requirements and Specification Design Document

    OpenAIRE

    Mokhov, Serguei A.

    2009-01-01

    We present the requirements and design specification of the open-source Distributed Modular Audio Recognition Framework (DMARF), a distributed extension of MARF. The distributed version aggregates a number of distributed technologies (e.g. Java RMI, CORBA, Web Services) in a pluggable and modular model along with the provision of advanced distributed systems algorithms. We outline the associated challenges incurred during the design and implementation as well as overall specification of the p...

  18. Tree Climbing Robot Design, Kinematics and Motion Planning

    CERN Document Server

    Lam, Tin Lun

    2012-01-01

    Climbing robot is a challenging research topic that has gained much attention from researchers. Most of the robots reported in the literature are designed to climb on manmade structures, but seldom robots are designed for climbing natural environment such as trees. Trees and manmade structures are very different in nature. It brings different aspects of technical challenges to the robot design. In this book, you can find a collection of the cutting edge technologies in the field of tree-climbing robot and the ways that animals climb. It provides a valuable reference for robot designers to select appropriate climbing methods in designing tree-climbing robots for specific purposes. Based on the study, a novel bio-inspired tree-climbing robot with several breakthrough performances has been developed and presents in this book. It is capable of performing various actions that is impossible in the state-of-the-art tree-climbing robots, such as moving between trunk and branches. This book also proposes several appro...

  19. A retrospective analysis for patient-specific quality assurance of volumetric-modulated arc therapy plans

    Energy Technology Data Exchange (ETDEWEB)

    Li, Guangjun [Radiation Physics Center, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan (China); Wu, Kui [Department of Radiotherapy, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province (China); Peng, Guang; Zhang, Yingjie [Radiation Physics Center, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan (China); Bai, Sen, E-mail: baisen@scu.edu.cn [Radiation Physics Center, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan (China)

    2014-01-01

    Volumetric-modulated arc therapy (VMAT) is now widely used clinically, as it is capable of delivering a highly conformal dose distribution in a short time interval. We retrospectively analyzed patient-specific quality assurance (QA) of VMAT and examined the relationships between the planning parameters and the QA results. A total of 118 clinical VMAT cases underwent pretreatment QA. All plans had 3-dimensional diode array measurements, and 69 also had ion chamber measurements. Dose distribution and isocenter point dose were evaluated by comparing the measurements and the treatment planning system (TPS) calculations. In addition, the relationship between QA results and several planning parameters, such as dose level, control points (CPs), monitor units (MUs), average field width, and average leaf travel, were also analyzed. For delivered dose distribution, a gamma analysis passing rate greater than 90% was obtained for all plans and greater than 95% for 100 of 118 plans with the 3%/3-mm criteria. The difference (mean ± standard deviation) between the point doses measured by the ion chamber and those calculated by TPS was 0.9% ± 2.0% for all plans. For all cancer sites, nasopharyngeal carcinoma and gastric cancer have the lowest and highest average passing rates, respectively. From multivariate linear regression analysis, the dose level (p = 0.001) and the average leaf travel (p < 0.001) showed negative correlations with the passing rate, and the average field width (p = 0.003) showed a positive correlation with the passing rate, all indicating a correlation between the passing rate and the plan complexity. No statistically significant correlation was found between MU or CP and the passing rate. Analysis of the results of dosimetric pretreatment measurements as a function of VMAT plan parameters can provide important information to guide the plan parameter setting and optimization in TPS.

  20. BERLinPro Booster Cavity Design, Fabrication and Test Plans

    Energy Technology Data Exchange (ETDEWEB)

    Burrill, Andrew [HZB; Anders, W [HZB; Frahm, A. [HZB; Knobloch, Jens [HZB; Neumann, Axel [HZB; Ciovati, Gianluigi [JLAB; Kneisel, Peter K. [JLAB; Turlington, Larry D. [JLAB

    2014-12-01

    The bERLinPro project, a 100 mA, 50 MeV superconducting RF (SRF) Energy Recovery Linac (ERL) is under construction at Helmholtz-Zentrum Berlin for the purpose of studying the technical challenges and physics of operating a high current, c.w., 1.3 GHz ERL. This machine will utilize three unique SRF cryomodules for the injector, booster and linac module respectively. The booster cryomodule will contain three 2-cell SRF cavities, based on the original design by Cornell University, and will be equipped with twin 115 kW RF power couplers in order to provide the appropriate acceleration to the high current electron beam. This paper will review the status of the fabrication of the 4 booster cavities that have been built for this project by Jefferson Laboratory and look at the challenges presented by the incorporation of fundamental power couplers capable of delivering 115 kW. The test plan for the cavities and couplers will be given along with a brief overview of the cryomodule design.

  1. Evolving strategies for optimal care management and plan benefit designs.

    Science.gov (United States)

    Cruickshank, John M

    2012-11-01

    As a prevalent, complex disease, diabetes presents a challenge to managed care. Strategies to optimize type 2 diabetes care management and treatment outcomes have been evolving over the past several years. Novel economic incentive programs (eg, those outlined in the Patient Protection and Affordable Care Act of 2010 that tie revenue from Medicare Advantage plans to the quality of healthcare delivered) are being implemented, as are evidence-based interventions designed to optimize treatment, reduce clinical complications, and lower the total financial burden of the disease. Another step that can improve outcomes is to align managed care diabetes treatment algorithms with national treatment guidelines. In addition, designing the pharmacy benefit to emphasize the overall value of treatment and minimize out-of-pocket expenses for patients can be an effective approach to reducing prescription abandonment. The implementation of emerging models of care that encourage collaboration between providers, support lifestyle changes, and engage patients to become partners in their own treatment also appears to be effective.

  2. Integrating planning and design optimization for thermal power generation in developing economies: Designs for Vietnam

    Science.gov (United States)

    Pham, John Dinh Chuong

    In the twenty first century, global warming and climate change have become environmental issues worldwide. There is a need to reduce greenhouse gas emissions from thermal power plants through improved efficiency. This need is shared by both developed and developing countries. It is particularly important in rapidly developing economies (for example, Vietnam, South Korea, and China) where there is very significant need to increase generation capacity. This thesis addresses improving thermal power plant efficiency through an improved planning process that emphasizes integrated design. With the integration of planning and design considerations of key components in thermal electrical generation, along with the selection of appropriate up-to-date technologies, greater efficiency and reduction of emissions could be achieved. The major barriers to the integration of overall power plant optimization are the practice of individual island tendering packages, and the lack of coordinating efforts between major original equipment manufacturers (OEM). This thesis assesses both operational and design aspects of thermal power plants to identify opportunities for energy saving and the associated reduction of CO2 emissions. To demonstrate the potential of the integrated planning design approach, three advanced thermal power plants, using anthracite coal, oil and gas as their respective fuel, were developed as a case study. The three plant formulations and simulations were performed with the cooperation of several leading companies in the power industry including Babcock & Wilcox, Siemens KWU, Siemens-Westinghouse Power Corporation, Hitachi, Alstom Air Preheater, TLT-Covent, and ABB Flakt. The first plant is a conventional W-Flame anthracite coal-fired unit for base load operation. The second is a supercritical oil-fired plant with advanced steam condition, for two shifting and cycling operations. The third plant is a gas-fired combined cycle unit employing a modern steam-cooled gas

  3. Planning and initiation of detailed engineering design for the Great Plains coal gasification project. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1980-01-01

    During the course of detailed engineering it was expected that preliminary engineering documents would need to be modified. In a number of instances, however, especially for flow diagrams and specifications, the revised preliminary engineering documents became the final approved for construction (AFC) documents. P and ID's and plot plans were updated as a result of the detailed piping design. Equipment data sheets which initially contained basic process data were made mechanically complete and then further updated to reflect the equipment actually purchased. The initial issue of the preliminary engineering documents represent a necessary baseline for monitoring project design changes. Foundation work, equipment specifications and status of engineering in the various process operations are discussed.

  4. Smoking-specific communication and children's smoking onset: An extension of the theory of planned behaviour

    NARCIS (Netherlands)

    Hiemstra, J.M.; Otten, R.; Schayck, O.C.P. van; Engels, R.C.M.E.

    2012-01-01

    The aim of this study was to test whether maternal smoking-specific communication and parental smoking related to smoking cognitions (i.e. attitude, self-efficacy and social norm) derived from the Theory of Planned Behaviour in association with smoking onset during preadolescence. A total of 1478 pa

  5. 40 CFR Appendix F to Part 112 - Facility-Specific Response Plan

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 21 2010-07-01 2010-07-01 false Facility-Specific Response Plan F Appendix F to Part 112 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS...., topography, drainage); (5) Location of the material discharged (i.e., on a concrete pad or directly on the...

  6. Hellsgate Big Game Winter Range Wildlife Mitigation Site Specific Management Plan for the Hellsgate Project.

    Energy Technology Data Exchange (ETDEWEB)

    Berger, Matthew T.; Judd, Steven L.

    1999-01-01

    This report contains a detailed site-specific management plan for the Hellsgate Winter Range Wildlife Mitigation Project. The report provides background information about the mitigation process, the review process, mitigation acquisitions, Habitat Evaluation Procedures (HEP) and mitigation crediting, current habitat conditions, desired future habitat conditions, restoration/enhancements efforts and maps.

  7. Smoking-specific communication and children's smoking onset: An extension of the theory of planned behaviour

    NARCIS (Netherlands)

    Hiemstra, J.M.; Otten, R.; Schayck, O.C.P. van; Engels, R.C.M.E.

    2012-01-01

    The aim of this study was to test whether maternal smoking-specific communication and parental smoking related to smoking cognitions (i.e. attitude, self-efficacy and social norm) derived from the Theory of Planned Behaviour in association with smoking onset during preadolescence. A total of 1478

  8. Environmental Restoration Site-Specific Plan for the Portsmouth Gaseous Diffusion Plant, FY 93

    Energy Technology Data Exchange (ETDEWEB)

    1993-01-15

    The purpose of this Site-Specific Plan (SSP) is to describe past, present, and future activities undertaken to implement Environmental Restoration and Waste Management goals at the Portsmouth Gaseous Diffusion Plant (PORTS). The SSP is presented in sections emphasizing Environmental Restoration description of activities, resources, and milestones.

  9. A Framework for Multi-Robot Motion Planning from Temporal Logic Specifications

    DEFF Research Database (Denmark)

    Koo, T. John; Li, Rongqing; Quottrup, Michael Melholt;

    2012-01-01

    -time Temporal Logic, Computation Tree Logic, and -calculus can be preserved. Motion planning can then be performed at a discrete level by considering the parallel composition of discrete abstractions of the robots with a requirement specification given in a suitable temporal logic. The bisimilarity ensures...

  10. 41 CFR 101-26.506 - Interior planning and design services.

    Science.gov (United States)

    2010-07-01

    ... design services. 101-26.506 Section 101-26.506 Public Contracts and Property Management Federal Property... SOURCES AND PROGRAM 26.5-GSA Procurement Programs § 101-26.506 Interior planning and design services. In... various phases of interior planning and design. These services will be provided either directly or...

  11. Empirical Test of the Know, See, Plan, Do Model for Curriculum Design in Leadership Education

    Science.gov (United States)

    Martin, Beth Ann; Allen, Scott J.

    2016-01-01

    This research assesses the Know, See, Plan, portions of the Know, See, Plan, Do (KSPD) model for curriculum design in leadership education. There were 3 graduate student groups, each taught using 1 of 3 different curriculum designs (KSPD and 2 control groups). Based on a pretest, post-test design, students' performance was measured to assess their…

  12. Rational Design of Antirheumatic Prodrugs Specific for Sites of Inflammation

    Science.gov (United States)

    Onuoha, Shimobi C.; Ferrari, Mathieu; Sblattero, Daniele

    2015-01-01

    Objective Biologic drugs, such as the anti–tumor necrosis factor (anti‐TNF) antibody adalimumab, have represented a breakthrough in the treatment of rheumatoid arthritis. Yet, concerns remain over their lack of efficacy in a sizable proportion of patients and their potential for systemic side effects such as infection. Improved biologic prodrugs specifically targeted to the site of inflammation have the potential to alleviate current concerns surrounding biologic anticytokine therapies. The purpose of this study was to design, construct, and evaluate in vitro and ex vivo the targeting and antiinflammatory capacity of activatable bispecific antibodies. Methods Activatable dual variable domain (aDVD) antibodies were designed and constructed to target intercellular adhesion molecule 1 (ICAM‐1), which is up‐regulated at sites of inflammation, and anti‐TNF antibodies (adalimumab and infliximab). These bispecific molecules included an external arm that targets ICAM‐1 and an internal arm that comprises the therapeutic domain of an anti‐TNF antibody. Both arms were linked to matrix metalloproteinase (MMP)–cleavable linkers. The constructs were tested for their ability to bind and neutralize both in vitro and ex vivo targets. Results Intact aDVD constructs demonstrated significantly reduced binding and anti‐TNF activity in the prodrug formulation as compared to the parent antibodies. Human synovial fluid and physiologic concentrations of MMP enzyme were capable of cleaving the external domain of the antibody, revealing a fully active molecule. Activated antibodies retained the same binding and anti‐TNF inhibitory capacities as the parent molecules. Conclusion The design of a biologic prodrug with enhanced specificity for sites of inflammation (synovium) and reduced specificity for off‐target TNF is described. This construct has the potential to form a platform technology that is capable of enhancing the therapeutic index of drugs for the treatment of

  13. A Video Specific Instruction Set Architecture for ASIP design

    Directory of Open Access Journals (Sweden)

    Zheng Shen

    2007-01-01

    Full Text Available This paper describes a novel video specific instruction set architecture for ASIP design. With single instruction multiple data (SIMD instructions, two destination modes, and video specific instructions, an instruction set architecture is introduced to enhance the performance for video applications. Furthermore, we quantify the improvement on H.263 encoding. In this paper, we evaluate and compare the performance of VS-ISA, other DSPs (digital signal processors, and conventional SIMD media extensions in the context of video coding. Our evaluation results show that VS-ISA improves the processor's performance by approximately 5x on H.263 encoding, and VS-ISA outperforms other architectures by 1.6x to 8.57x in computing IDCT.

  14. Advanced Wet Tantalum Capacitors: Design, Specifications and Performance

    Science.gov (United States)

    Teverovsky, Alexander

    2017-01-01

    Insertion of new types of commercial, high volumetric efficiency wet tantalum capacitors in space systems requires reassessment of the existing quality assurance approaches that have been developed for capacitors manufactured to MIL-PRF-39006 requirements. The specifics of wet electrolytic capacitors is that leakage currents flowing through electrolyte can cause gas generation resulting in building up of internal gas pressure and rupture of the case. The risk associated with excessive leakage currents and increased pressure is greater for high value advanced wet tantalum capacitors, but it has not been properly evaluated yet. This presentation gives a review of specifics of the design, performance, and potential reliability risks associated with advanced wet tantalum capacitors. Problems related to setting adequate requirements for DPA, leakage currents, hermeticity, stability at low and high temperatures, ripple currents for parts operating in vacuum, and random vibration testing are discussed. Recommendations for screening and qualification to reduce risks of failures have been suggested.

  15. Compressive imaging system design using task-specific information.

    Science.gov (United States)

    Ashok, Amit; Baheti, Pawan K; Neifeld, Mark A

    2008-09-01

    We present a task-specific information (TSI) based framework for designing compressive imaging (CI) systems. The task of target detection is chosen to demonstrate the performance of the optimized CI system designs relative to a conventional imager. In our optimization framework, we first select a projection basis and then find the associated optimal photon-allocation vector in the presence of a total photon-count constraint. Several projection bases, including principal components (PC), independent components, generalized matched-filter, and generalized Fisher discriminant (GFD) are considered for candidate CI systems, and their respective performance is analyzed for the target-detection task. We find that the TSI-optimized CI system design based on a GFD projection basis outperforms all other candidate CI system designs as well as the conventional imager. The GFD-based compressive imager yields a TSI of 0.9841 bits (out of a maximum possible 1 bit for the detection task), which is nearly ten times the 0.0979 bits achieved by the conventional imager at a signal-to-noise ratio of 5.0. We also discuss the relation between the information-theoretic TSI metric and a conventional statistical metric like probability of error in the context of the target-detection problem. It is shown that the TSI can be used to derive an upper bound on the probability of error that can be attained by any detection algorithm.

  16. Novel Designs for Application Specific MEMS Pressure Sensors

    DEFF Research Database (Denmark)

    Fragiacomo, Giulio; Reck, Kasper; Lorenzen, Lasse Vestergaard

    2010-01-01

    In the framework of developing innovative microfabricated pressure sensors, we present here three designs based on different readout principles, each one tailored for a specific application. A touch mode capacitive pressure sensor with high sensitivity (14 pF/bar), low temperature dependence...... and high capacitive output signal (more than 100 pF) is depicted. An optical pressure sensor intrinsically immune to electromagnetic interference, with large pressure range (0-350 bar) and a sensitivity of 1 pm/bar is presented. Finally, a resonating wireless pressure sensor power source free...

  17. Integrating Cloud-Computing-Specific Model into Aircraft Design

    Science.gov (United States)

    Zhimin, Tian; Qi, Lin; Guangwen, Yang

    Cloud Computing is becoming increasingly relevant, as it will enable companies involved in spreading this technology to open the door to Web 3.0. In the paper, the new categories of services introduced will slowly replace many types of computational resources currently used. In this perspective, grid computing, the basic element for the large scale supply of cloud services, will play a fundamental role in defining how those services will be provided. The paper tries to integrate cloud computing specific model into aircraft design. This work has acquired good results in sharing licenses of large scale and expensive software, such as CFD (Computational Fluid Dynamics), UG, CATIA, and so on.

  18. Design and Evaluation of Tumor-Specific Dendrimer Epigenetic Therapeutics

    Science.gov (United States)

    Zong, Hong; Shah, Dhavan; Selwa, Katherine; Tsuchida, Ryan E; Rattan, Rahul; Mohan, Jay; Stein, Adam B; Otis, James B; Goonewardena, Sascha N

    2015-01-01

    Histone deacetylase inhibitors (HDACi) are promising therapeutics for cancer. HDACi alter the epigenetic state of tumors and provide a unique approach to treat cancer. Although studies with HDACi have shown promise in some cancers, variable efficacy and off-target effects have limited their use. To overcome some of the challenges of traditional HDACi, we sought to use a tumor-specific dendrimer scaffold to deliver HDACi directly to cancer cells. Here we report the design and evaluation of tumor-specific dendrimer–HDACi conjugates. The HDACi was conjugated to the dendrimer using an ester linkage through its hydroxamic acid group, inactivating the HDACi until it is released from the dendrimer. Using a cancer cell model, we demonstrate the functionality of the tumor-specific dendrimer–HDACi conjugates. Furthermore, we demonstrate that unlike traditional HDACi, dendrimer–HDACi conjugates do not affect tumor-associated macrophages, a recently recognized mechanism through which drug resistance emerges. We anticipate that this new class of cell-specific epigenetic therapeutics will have tremendous potential in the treatment of cancer. PMID:26246996

  19. Mod-5A wind turbine generator program design report. Volume 4: Drawings and specifications, book 2

    Science.gov (United States)

    1984-01-01

    The design, development and analysis of the 7.3 MW MOD-5A wind turbine generator is documented. There are four volumes. This volume contains the drawings and specifications that were developed in preparation for building the MOD-5A wind turbine generator. This is the second book of volume four. Some of the items it contains are specs for the emergency shutdown panel, specs for the simulator software, simulator hardware specs, site operator terminal requirements, control data system requirements, software project management plan, elastomeric teeter bearing requirement specs, specs for the controls electronic cabinet, and specs for bolt pretensioning.

  20. Flexibility in Flood Management Design: Proactive Planning Under Climate Change Uncertainty

    Science.gov (United States)

    Smet, K.; de Neufville, R.; van der Vlist, M.

    2015-12-01

    This paper presents an innovative, value-enhancing procedure for effective planning and design of long-lived flood management infrastructure given uncertain future flooding threats due to climate change. Designing infrastructure that can be adapted over time is a method to safeguard the efficacy of current design decisions given uncertainty about rates and future impacts of climate change. This paper explores the value of embedding "options" in a physical structure, where an option is the right but not the obligation to do something at a later date (e.g. over-dimensioning a floodwall foundation now facilitates a future height addition in response to observed increases in sea level; building of extra pump bays in a pumping station now enables the addition of pumping capacity whenever increased precipitation warrants an expansion.) The proposed procedure couples a simulation model that captures future climate induced changes to the hydrologic operating environment of a structure, with an economic model that estimates the lifetime economic performance of alternative investments. The economic model uses Real "In" Options analysis, a type of cash flow analysis that quantifies the implicit value of options and the flexibility they provide. This procedure is demonstrated using replacement planning for the multi-functional pumping station IJmuiden on the North Sea Canal in the Netherlands. Flexibility in design decisions is modelled, varying the size and specific options included in the new structure. Results indicate that the incorporation of options within the structural design has the potential to improve its economic performance, as compared to more traditional, "build it once and build it big" designs where flexibility is not an explicit design criterion. The added value resulting from the incorporation of flexibility varies with the range of future conditions considered, as well as the options examined. This procedure could be applied more broadly to explore

  1. Water-related planning and design at energy firms

    Energy Technology Data Exchange (ETDEWEB)

    Abbey, D; Lucero, F

    1980-11-01

    Water related planning and design at energy firms are examined. By identifying production alternatives and specifying the cost of these alternatives under a variety of conditions, one gains insight into the future pattern of water use in the energy industry and the response of industry to water-related regulation. In Part II, the three principal decisions of industry that affect water allocation are reviewed: where to build plants, where to get water, and how much water to use. The cost of water use alternatives is reviewed. Part III presents empirical data to substantiate the inferences derived from engineering/economic analysis. The source of water, type of cooling system, and pattern of discharge for electric plants constructed during the 1970s or projected to come on line in this decade are reported. In the 1970s in the US, there was a trend away from once-through cooling toward use of evaporative cooling. Freshwater, as a source of supply, and discharge of effluent were standard practice. In the 1980s, almost all new capacity in the states and basins surveyed will use evaporative cooling. It is pointed out that a thorough understanding of industrial water use economics and water markets is a precursor to successful regulation.

  2. Hayabusa 2 extension plan: Asteroid selection and trajectory design

    Science.gov (United States)

    Sarli, Bruno Victorino; Tsuda, Yuichi

    2017-09-01

    The Hayabusa 2 mission is targeted to explore the asteroid (162173) 1999 JU3 and return surface as well as sub-surface samples through a novel impactor. Upon its return, at the end of 2020, the spacecraft will release the capsule for Earth re-entry and drift away from the planet. Based on the current mission profile, the spacecraft is expected to retain 30 kg of xenon propellant for trajectory maneuvers after the capsule is released. This remaining fuel can be used to extend the mission and improve its scientific return by exploring a new target. Work herein outlines an extension plan for Hayabusa 2, detailing the target selection process and its subsequent trajectory design. Due to final Earth escape trajectory, considering the excess velocity and orbital geometry, the only available extension option is an asteroid flyby. One of the most important trajectory characteristic is to maximize the spacecraft's optical detection capabilities. As a result the asteroid 2001 WR1 is identified as the most promising target candidate. The resulting trajectory uses all the available xenon with 100% duty cycle. Furthermore, the extension lasts for 932 days and offers 1.57 days of optical navigation time for a flyby on June 27, 2023.

  3. Refining SCJ Mission Specifications into Parallel Handler Designs

    Directory of Open Access Journals (Sweden)

    Frank Zeyda

    2013-05-01

    Full Text Available Safety-Critical Java (SCJ is a recent technology that restricts the execution and memory model of Java in such a way that applications can be statically analysed and certified for their real-time properties and safe use of memory. Our interest is in the development of comprehensive and sound techniques for the formal specification, refinement, design, and implementation of SCJ programs, using a correct-by-construction approach. As part of this work, we present here an account of laws and patterns that are of general use for the refinement of SCJ mission specifications into designs of parallel handlers used in the SCJ programming paradigm. Our notation is a combination of languages from the Circus family, supporting state-rich reactive models with the addition of class objects and real-time properties. Our work is a first step to elicit laws of programming for SCJ and fits into a refinement strategy that we have developed previously to derive SCJ programs.

  4. A drug-specific nanocarrier design for efficient anticancer therapy

    Science.gov (United States)

    Shi, Changying; Guo, Dandan; Xiao, Kai; Wang, Xu; Wang, Lili; Luo, Juntao

    2015-01-01

    The drug-loading properties of nanocarriers depend on the chemical structures and properties of their building blocks. Here, we customize telodendrimers (linear-dendritic copolymer) to design a nanocarrier with improved in vivo drug delivery characteristics. We do a virtual screen of a library of small molecules to identify the optimal building blocks for precise telodendrimer synthesis using peptide chemistry. With rationally designed telodendrimer architectures, we then optimize the drug binding affinity of a nanocarrier by introducing an optimal drug-binding molecule (DBM) without sacrificing the stability of the nanocarrier. To validate the computational predictions, we synthesize a series of nanocarriers and evaluate systematically for doxorubicin delivery. Rhein-containing nanocarriers have sustained drug release, prolonged circulation, increased tolerated dose, reduced toxicity, effective tumor targeting and superior anticancer effects owing to favourable doxorubicin-binding affinity and improved nanoparticle stability. This study demonstrates the feasibility and versatility of the de novo design of telodendrimer nanocarriers for specific drug molecules, which is a promising approach to transform nanocarrier development for drug delivery. PMID:26158623

  5. Design Patterns for Self-Adaptive RTE Systems Specification

    Directory of Open Access Journals (Sweden)

    Mouna Ben Said

    2014-01-01

    Full Text Available The development of self-adaptive real-time embedded (RTE systems is an increasingly hard task due to the growing complexity of both hardware and software and the high variability of the execution environment. Different approaches, platforms, and middleware have been proposed in the field, from low to high abstraction level. However, there is still a lack of generic and reusable designs for self-adaptive RTE systems that fit different system domains, lighten designers’ task, and decrease development cost. In this paper, we propose five design patterns for self-adaptive RTE systems modeling resulting from the generalization of relevant existing adaptation-related works. Combined together, the patterns form the design of an adaptation loop composed of five adaptation modules. The proposed solution offers a modular, reusable, and flexible specification of these modules and enables the separation of concerns. It also permits dealing with concurrency, real-time features, and adaptation cost relative to the adaptation activities. To validate our solution, we applied it to a complex case study, a cross-layer self-adaptive object tracking system, to show patterns utilization and prove the solution benefits.

  6. Planned missing designs to optimize the efficiency of latent growth parameter estimates

    NARCIS (Netherlands)

    Rhemtulla, M.; Jia, F.; Wu, W.; Little, T.D.

    2014-01-01

    We examine the performance of planned missing (PM) designs for correlated latent growth curve models. Using simulated data from a model where latent growth curves are fitted to two constructs over five time points, we apply three kinds of planned missingness. The first is item-level planned missingn

  7. An integrated in silico approach to design specific inhibitors targeting human poly(a-specific ribonuclease.

    Directory of Open Access Journals (Sweden)

    Dimitrios Vlachakis

    Full Text Available Poly(A-specific ribonuclease (PARN is an exoribonuclease/deadenylase that degrades 3'-end poly(A tails in almost all eukaryotic organisms. Much of the biochemical and structural information on PARN comes from the human enzyme. However, the existence of PARN all along the eukaryotic evolutionary ladder requires further and thorough investigation. Although the complete structure of the full-length human PARN, as well as several aspects of the catalytic mechanism still remain elusive, many previous studies indicate that PARN can be used as potent and promising anti-cancer target. In the present study, we attempt to complement the existing structural information on PARN with in-depth bioinformatics analyses, in order to get a hologram of the molecular evolution of PARNs active site. In an effort to draw an outline, which allows specific drug design targeting PARN, an unequivocally specific platform was designed for the development of selective modulators focusing on the unique structural and catalytic features of the enzyme. Extensive phylogenetic analysis based on all the publicly available genomes indicated a broad distribution for PARN across eukaryotic species and revealed structurally important amino acids which could be assigned as potentially strong contributors to the regulation of the catalytic mechanism of PARN. Based on the above, we propose a comprehensive in silico model for the PARN's catalytic mechanism and moreover, we developed a 3D pharmacophore model, which was subsequently used for the introduction of DNP-poly(A amphipathic substrate analog as a potential inhibitor of PARN. Indeed, biochemical analysis revealed that DNP-poly(A inhibits PARN competitively. Our approach provides an efficient integrated platform for the rational design of pharmacophore models as well as novel modulators of PARN with therapeutic potential.

  8. Designing a Repetitive Group Sampling Plan for Weibull Distributed Processes

    Directory of Open Access Journals (Sweden)

    Aijun Yan

    2016-01-01

    Full Text Available Acceptance sampling plans are useful tools to determine whether the submitted lots should be accepted or rejected. An efficient and economic sampling plan is very desirable for the high quality levels required by the production processes. The process capability index CL is an important quality parameter to measure the product quality. Utilizing the relationship between the CL index and the nonconforming rate, a repetitive group sampling (RGS plan based on CL index is developed in this paper when the quality characteristic follows the Weibull distribution. The optimal plan parameters of the proposed RGS plan are determined by satisfying the commonly used producer’s risk and consumer’s risk at the same time by minimizing the average sample number (ASN and then tabulated for different combinations of acceptance quality level (AQL and limiting quality level (LQL. The results show that the proposed plan has better performance than the single sampling plan in terms of ASN. Finally, the proposed RGS plan is illustrated with an industrial example.

  9. 75 FR 2091 - Approval and Promulgation of Implementation Plans and Designation of Areas for Air Quality...

    Science.gov (United States)

    2010-01-14

    ... quality design value. Shelby County, Tennessee was originally designated as a marginal nonattainment area... for Air Quality Planning Purposes; Arkansas; Redesignation of the Crittenden County, Arkansas Portion... Arkansas, through the Arkansas Department of Environmental Quality (ADEQ), submitted a request...

  10. Translating research into practice through user-centered design: An application for osteoarthritis healthcare planning.

    Science.gov (United States)

    Carr, Eloise Cj; Babione, Julie N; Marshall, Deborah

    2017-08-01

    To identify the needs and requirements of the end users, to inform the development of a user-interface to translate an existing evidence-based decision support tool into a practical and usable interface for health service planning for osteoarthritis (OA) care. We used a user-centered design (UCD) approach that emphasized the role of the end-users and is well-suited to knowledge translation (KT). The first phase used a needs assessment focus group (n=8) and interviews (n=5) with target users (health care planners) within a provincial health care organization. The second phase used a participatory design approach, with two small group sessions (n=6) to explore workflow, thought processes, and needs of intended users. The needs assessment identified five design recommendations: ensuring the user-interface supports the target user group, allowing for user-directed data explorations, input parameter flexibility, clear presentation, and provision of relevant definitions. The second phase identified workflow insights from a proposed scenario. Graphs, the need for a visual overview of the data, and interactivity were key considerations to aid in meaningful use of the model and knowledge translation. A UCD approach is well suited to identify health care planners' requirements when using a decision support tool to improve health service planning and management of OA. We believe this is one of the first applications to be used in planning for health service delivery. We identified specific design recommendations that will increase user acceptability and uptake of the user-interface and underlying decision support tool in practice. Our approach demonstrated how UCD can be used to enable knowledge translation. Copyright © 2017 Elsevier B.V. All rights reserved.

  11. Toward optimizing patient-specific IMRT QA techniques in the accurate detection of dosimetrically acceptable and unacceptable patient plans.

    Science.gov (United States)

    McKenzie, Elizabeth M; Balter, Peter A; Stingo, Francesco C; Jones, Jimmy; Followill, David S; Kry, Stephen F

    2014-12-01

    The authors investigated the performance of several patient-specific intensity-modulated radiation therapy (IMRT) quality assurance (QA) dosimeters in terms of their ability to correctly identify dosimetrically acceptable and unacceptable IMRT patient plans, as determined by an in-house-designed multiple ion chamber phantom used as the gold standard. A further goal was to examine optimal threshold criteria that were consistent and based on the same criteria among the various dosimeters. The authors used receiver operating characteristic (ROC) curves to determine the sensitivity and specificity of (1) a 2D diode array undergoing anterior irradiation with field-by-field evaluation, (2) a 2D diode array undergoing anterior irradiation with composite evaluation, (3) a 2D diode array using planned irradiation angles with composite evaluation, (4) a helical diode array, (5) radiographic film, and (6) an ion chamber. This was done with a variety of evaluation criteria for a set of 15 dosimetrically unacceptable and 9 acceptable clinical IMRT patient plans, where acceptability was defined on the basis of multiple ion chamber measurements using independent ion chambers and a phantom. The area under the curve (AUC) on the ROC curves was used to compare dosimeter performance across all thresholds. Optimal threshold values were obtained from the ROC curves while incorporating considerations for cost and prevalence of unacceptable plans. Using common clinical acceptance thresholds, most devices performed very poorly in terms of identifying unacceptable plans. Grouping the detector performance based on AUC showed two significantly different groups. The ion chamber, radiographic film, helical diode array, and anterior-delivered composite 2D diode array were in the better-performing group, whereas the anterior-delivered field-by-field and planned gantry angle delivery using the 2D diode array performed less well. Additionally, based on the AUCs, there was no significant difference

  12. Stochastic sensors designed for assessment of biomarkers specific to obesity.

    Science.gov (United States)

    Cioates Negut, Catalina; Stefan-van Staden, Raluca-Ioana; Ungureanu, Eleonora-Mihaela; Udeanu, Denisa Ioana

    2016-09-01

    Two stochastic sensors based on the following oleamides: 1-adamantyloleamide and N,N-dimethyl-N-(2-oleylamidoethyl)amine physically immobilized on graphite paste were designed. The sensors were able to determine simultaneously from the whole blood of Wistar rats three biomarkers specific to obesity: leptin, interleukin-6 (IL-6) and plasminogen activator inhibitor 1 (PAI-1). The whole blood samples were obtained from Wistar rats treated with oleoylethanolamide (OEA), (Z)-N-[(1S)-2-hidroxy-1-(phenylmethyl) ethyl]-9octadecenamide (OLA), and with the aqueous solution of 1% Tween 80 used as solvent for oleamides formulations (control samples). The proposed sensors were very sensitive and reliable for the assay of obesity biomarkers in whole blood of rats.

  13. An overview of field-specific designs of microbial EOR

    Energy Technology Data Exchange (ETDEWEB)

    Robertson, E.P.; Bala, G.A.; Fox, S.L.; Jackson, J.D.; Thomas, C.P. [Idaho National Engineering Lab., Idaho Falls, ID (United States)

    1995-12-31

    The selection and design of an MEOR process for application in a specific field involves geological, reservoir, and biological characterization. Microbially mediated oil recovery mechanisms (bigenic gas, biopolymers, and biosurfactants) are defined by the types of microorganisms used. The engineering and biological character of a given reservoir must be understood to correctly select a microbial system to enhance oil recovery. This paper discusses the methods used to evaluate three fields with distinct characteristics and production problems for the applicability of MEOR would not be applicable in two of the three fields considered. The development of a microbial oil recovery process for the third field appeared promising. Development of a bacterial consortium capable of producing the desired metabolites was initiated, and field isolates were characterized.

  14. Phase Transitions in Planning Problems: Design and Analysis of Parameterized Families of Hard Planning Problems

    Science.gov (United States)

    Hen, Itay; Rieffel, Eleanor G.; Do, Minh; Venturelli, Davide

    2014-01-01

    There are two common ways to evaluate algorithms: performance on benchmark problems derived from real applications and analysis of performance on parametrized families of problems. The two approaches complement each other, each having its advantages and disadvantages. The planning community has concentrated on the first approach, with few ways of generating parametrized families of hard problems known prior to this work. Our group's main interest is in comparing approaches to solving planning problems using a novel type of computational device - a quantum annealer - to existing state-of-the-art planning algorithms. Because only small-scale quantum annealers are available, we must compare on small problem sizes. Small problems are primarily useful for comparison only if they are instances of parametrized families of problems for which scaling analysis can be done. In this technical report, we discuss our approach to the generation of hard planning problems from classes of well-studied NP-complete problems that map naturally to planning problems or to aspects of planning problems that many practical planning problems share. These problem classes exhibit a phase transition between easy-to-solve and easy-to-show-unsolvable planning problems. The parametrized families of hard planning problems lie at the phase transition. The exponential scaling of hardness with problem size is apparent in these families even at very small problem sizes, thus enabling us to characterize even very small problems as hard. The families we developed will prove generally useful to the planning community in analyzing the performance of planning algorithms, providing a complementary approach to existing evaluation methods. We illustrate the hardness of these problems and their scaling with results on four state-of-the-art planners, observing significant differences between these planners on these problem families. Finally, we describe two general, and quite different, mappings of planning

  15. The design and implementation of decision support tools of proton beam therapy treatment planning of brain cancer patients

    Science.gov (United States)

    Le, Anh; Documet, Jorge; Joseph, Anika; Schulte, Reinhard; Liu, Brent

    2008-03-01

    Last year, we presented methodology to perform knowledge-based medical imaging informatics research on specific clinical scenarios where brain tumor patients are treated with Proton Beam Therapy (PT). In this presentation, we demonstrate the design and implementation of quantification and visualization tools to develop the knowledge base for therapy treatment planning based on DICOM-RT-ION objects. Proton Beam Therapy (PT) is a particular treatment that utilizes energized charged particles, protons, to deliver dose to the target region. Similar to traditional Radiation Therapy (RT), complex clinical imaging and informatics data are generated during the treatment process that guide the planning and the success of the treatment. Therefore, an Electronic Patient Record (ePR) System has been developed to standardize and centralize clinical imaging and informatics data and properly distribute data throughout the treatment duration. To further improve treatment planning process, we developed a set of decision support tools to improve the QA process in treatment planning process. One such example is a tool to assist in the planning of stereotactic PT cases where CT and MR images need to be analyzed simultaneously during treatment plan assessment. These tools are add-on features for DICOM standard ePR system of brain cancer patients and improve the clinical efficiency of PT treatment planning. Additional outcome data collected for PT cases are included in the overall DICOM-RT-ION database design as knowledge to enhance outcomes analysis for future PT adopters.

  16. Designing Spaces: Visualizing, Planning, and Building. Seeing and Thinking Mathematically in the Middle Grades.

    Science.gov (United States)

    Kleiman, Glenn; Zweig, Karen

    In this unit of the Seeing and Thinking Mathematically series, students use geometry to analyze buildings from around the world, design and build their own house models, create plans for their designs, and build from each other's plans. Students start out the unit building with cubes and later move to other geometric shapes. As they learn to…

  17. Planned Missing Data Designs with Small Sample Sizes: How Small Is Too Small?

    Science.gov (United States)

    Jia, Fan; Moore, E. Whitney G.; Kinai, Richard; Crowe, Kelly S.; Schoemann, Alexander M.; Little, Todd D.

    2014-01-01

    Utilizing planned missing data (PMD) designs (ex. 3-form surveys) enables researchers to ask participants fewer questions during the data collection process. An important question, however, is just how few participants are needed to effectively employ planned missing data designs in research studies. This article explores this question by using…

  18. Family and Consumer Sciences: A Facility Planning and Design Guide for School Systems.

    Science.gov (United States)

    Maryland State Dept. of Education, Baltimore.

    This document presents design concepts and considerations for planning and developing middle and high school family and consumer sciences education facilities. It includes discussions on family and consumer sciences education trends and the facility planning process. Design concepts explore multipurpose laboratories and spaces for food/nutrition…

  19. Origins Space Telescope: Telescope Design and Instrument Specifications

    Science.gov (United States)

    Meixner, Margaret; Carter, Ruth; Leisawitz, David; Dipirro, Mike; Flores, Anel; Staguhn, Johannes; Kellog, James; Roellig, Thomas L.; Melnick, Gary J.; Bradford, Charles; Wright, Edward L.; Zmuidzinas, Jonas; Origins Space Telescope Study Team

    2017-01-01

    The Origins Space Telescope (OST) is the mission concept for the Far-Infrared Surveyor, one of the four science and technology definition studies of NASA Headquarters for the 2020 Astronomy and Astrophysics Decadal survey. The renaming of the mission reflects Origins science goals that will discover and characterize the most distant galaxies, nearby galaxies and the Milky Way, exoplanets, and the outer reaches of our Solar system. This poster will show the preliminary telescope design that will be a large aperture (>8 m in diameter), cryogenically cooled telescope. We will also present the specifications for the spectrographs and imagers over a potential wavelength range of ~10 microns to 1 millimeter. We look forward to community input into this mission definition over the coming year as we work on the concept design for the mission. Origins will enable flagship-quality general observing programs led by the astronomical community in the 2030s. We welcome you to contact the Science and Technology Definition Team (STDT) with your science needs and ideas by emailing us at firsurveyor_info@lists.ipac.caltech.edu.

  20. Polyamide platinum anticancer complexes designed to target specific DNA sequences.

    Science.gov (United States)

    Jaramillo, David; Wheate, Nial J; Ralph, Stephen F; Howard, Warren A; Tor, Yitzhak; Aldrich-Wright, Janice R

    2006-07-24

    Two new platinum complexes, trans-chlorodiammine[N-(2-aminoethyl)-4-[4-(N-methylimidazole-2-carboxamido)-N-methylpyrrole-2-carboxamido]-N-methylpyrrole-2-carboxamide]platinum(II) chloride (DJ1953-2) and trans-chlorodiammine[N-(6-aminohexyl)-4-[4-(N-methylimidazole-2-carboxamido)-N-methylpyrrole-2-carboxamido]-N-methylpyrrole-2-carboxamide]platinum(II) chloride (DJ1953-6) have been synthesized as proof-of-concept molecules in the design of agents that can specifically target genes in DNA. Coordinate covalent binding to DNA was demonstrated with electrospray ionization mass spectrometry. Using circular dichroism, these complexes were found to show greater DNA binding affinity to the target sequence: d(CATTGTCAGAC)(2), than toward either d(GTCTGTCAATG)(2,) which contains different flanking sequences, or d(CATTGAGAGAC)(2), which contains a double base pair mismatch sequence. DJ1953-2 unwinds the DNA helix by around 13 degrees , but neither metal complex significantly affects the DNA melting temperature. Unlike simple DNA minor groove binders, DJ1953-2 is able to inhibit, in vitro, RNA synthesis. The cytotoxicity of both metal complexes in the L1210 murine leukaemia cell line was also determined, with DJ1953-6 (34 microM) more active than DJ1953-2 (>50 microM). These results demonstrate the potential of polyamide platinum complexes and provide the structural basis for designer agents that are able to recognize biologically relevant sequences and prevent DNA transcription and replication.

  1. The Development of Educational Specifications. School Planning Guide--Series 3R.

    Science.gov (United States)

    Pearson, Douglas L.

    This publication has been developed to assist local boards of education, superintendents, and their staffs in the organization and development of educational specifications. Part 1 presents a conceptual and operating primer on what educational specifications are--the purpose, the process, the personnel, and the product. Part 2 is designed to…

  2. A new specifically designed forceps for chest drain insertion.

    LENUS (Irish Health Repository)

    Andrews, Emmet

    2012-02-03

    Insertion of a chest drain can be associated with serious complications. It is recommended that the drain is inserted with blunt dissection through the chest wall but there is no specific instrument to aid this task. We describe a new reusable forceps that has been designed specifically to facilitate the insertion of chest drains.A feasibility study of its use in patients who required a chest drain as part of elective cardiothoracic operations was undertaken. The primary end-point was successful and accurate placement of the drain. The operators also completed a questionnaire rating defined aspects of the procedure. The new instrument was used to insert the chest drain in 30 patients (19 male, 11 female; median age 61.5 years (range 16-81 years)). The drain was inserted successfully without the trocar in all cases and there were no complications. Use of the instrument rated as significantly easier relative to experience of previous techniques in all specified aspects. The new device can be used to insert intercostal chest drains safely and efficiently without using the trocar or any other instrument.

  3. Evolution of design considerations in complex craniofacial reconstruction using patient-specific implants.

    Science.gov (United States)

    Peel, Sean; Bhatia, Satyajeet; Eggbeer, Dominic; Morris, Daniel S; Hayhurst, Caroline

    2017-06-01

    Previously published evidence has established major clinical benefits from using computer-aided design, computer-aided manufacturing, and additive manufacturing to produce patient-specific devices. These include cutting guides, drilling guides, positioning guides, and implants. However, custom devices produced using these methods are still not in routine use, particularly by the UK National Health Service. Oft-cited reasons for this slow uptake include the following: a higher up-front cost than conventionally fabricated devices, material-choice uncertainty, and a lack of long-term follow-up due to their relatively recent introduction. This article identifies a further gap in current knowledge - that of design rules, or key specification considerations for complex computer-aided design/computer-aided manufacturing/additive manufacturing devices. This research begins to address the gap by combining a detailed review of the literature with first-hand experience of interdisciplinary collaboration on five craniofacial patient case studies. In each patient case, bony lesions in the orbito-temporal region were segmented, excised, and reconstructed in the virtual environment. Three cases translated these digital plans into theatre via polymer surgical guides. Four cases utilised additive manufacturing to fabricate titanium implants. One implant was machined from polyether ether ketone. From the literature, articles with relevant abstracts were analysed to extract design considerations. In all, 19 frequently recurring design considerations were extracted from previous publications. Nine new design considerations were extracted from the case studies - on the basis of subjective clinical evaluation. These were synthesised to produce a design considerations framework to assist clinicians with prescribing and design engineers with modelling. Promising avenues for further research are proposed.

  4. 41 CFR 102-76.20 - What issues must Federal agencies consider in providing site planning and landscape design services?

    Science.gov (United States)

    2010-07-01

    ... agencies consider in providing site planning and landscape design services? 102-76.20 Section 102-76.20... What issues must Federal agencies consider in providing site planning and landscape design services? In providing site planning and design services, Federal agencies must— (a) Make the site planning and...

  5. Essays on Infrastructure Design and Planning for Clean Energy Systems

    Science.gov (United States)

    Kocaman, Ayse Selin

    The International Energy Agency estimates that the number of people who do not have access to electricity is nearly 1.3 billion and a billion more have only unreliable and intermittent supply. Moreover, current supply for electricity generation mostly relies on fossil fuels, which are finite and one of the greatest threats to the environment. Rising population growth rates, depleting fuel sources, environmental issues and economic developments have increased the need for mathematical optimization to provide a formal framework that enables systematic and clear decision-making in energy operations. This thesis through its methodologies and algorithms enable tools for energy generation, transmission and distribution system design and help policy makers make cost assessments in energy infrastructure planning rapidly and accurately. In Chapter 2, we focus on local-level power distribution systems planning for rural electrification using techniques from combinatorial optimization. We describe a heuristic algorithm that provides a quick solution for the partial electrification problem where the distribution network can only connect a pre-specified number of households with low voltage lines. The algorithm demonstrates the effect of household settlement patterns on the electrification cost. We also describe the first heuristic algorithm that selects the locations and service areas of transformers without requiring candidate solutions and simultaneously builds a two-level grid network in a green-field setting. The algorithms are applied to real world rural settings in Africa, where household locations digitized from satellite imagery are prescribed. In Chapter 3 and 4, we focus on power generation and transmission using clean energy sources. Here, we imagine a country in the future where hydro and solar are the dominant sources and fossil fuels are only available in minimal form. We discuss the problem of modeling hydro and solar energy production and allocation, including

  6. 78 FR 20868 - Approval and Promulgation of Implementation Plans; Designation of Areas for Air Quality Planning...

    Science.gov (United States)

    2013-04-08

    ... INFORMATION CONTACT: Wienke Tax, U.S. Environmental Protection Agency, Air Planning Office, Region IX, (415... Air Quality Planning Purposes; State of California; PM 10 ; Redesignation of the South Coast Air Basin.... Email: tax.wienke@epa.gov . 3. Mail or Deliver: Wienke Tax (Air-2), U.S. Environmental Protection Agency...

  7. Progress in the design of manufacturing plan and planning new product development in indefinite situations

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ How to embed those indefinite situations and nonlinear factors derived from a complicated industry environment into the production planning and new product development (NPD) planning, and the further establishment of fuzzy decision models, are very important issues in decision-making in manufacturing and operation administration.

  8. SU-E-T-603: PBS Prostate Plan Robustness: A Tool for Patient Specific Setup Tolerance

    Energy Technology Data Exchange (ETDEWEB)

    Tang, S; Song, L; Chen, C; Chang, C; Chon, B; Tsai, H; Soffen, E; Cahlon, O; Mah, D [Procure Proton Therapy Center, Somerset, NJ (United States)

    2015-06-15

    Purpose: Fiducial markers are commonly used for setup of prostate patients using orthogonal radiographs. After aligned with the markers, the displacement of the bony anatomy relative to the planned DRR can be up to 10 mm. Such offset can potentially have significant dosimetric effects because it changes the radiological path length of protons in differing amounts of bone. It is imperative to develop a method to evaluate its impact on target coverage and hence establish patient specific setup tolerance for prostate proton PBS treatment. Methods: Prostate patients were planned in RayStation according to the PCG protocol with bi-lateral beams. The primary planning objectives are: (1) 100% of CTV receives full prescription dose; (2) 98% of the prescription dose covers at least 98% of the PTV; (3) OARs meet criteria per protocol. For each patient 108 dose perturbations were automatically generated using an in-house script, which considered the isocenter shifting in S-I and A-P directions (up to ±15 mm with an interval of 6mm) as well as the range uncertainty (±3.5%). The target coverage was evaluated on the contour shifted along with prostate to mimic the daily treatment. Results: The minimum CTV coverage as a function of offsets in S-I and A-P directions is presented in a 2D contour map. The offsets along A-P direction generally have greater impact than along S-I direction. Both the CTV D98%>98% or CTV V98%>98% are achievable for most patients if the offset is <10 mm in either direction despite of range uncertainties. Conclusion: We developed a method to evaluate the plan robustness for proton PBS prostate treatment. It can provide patient specific setup tolerance of bony structure offset. For our current planning approach, a 1 cm displacement is acceptable. This approach can be generalized to other target structures that move relative to bony anatomy.

  9. MODIS Information, Data, and Control System (MIDACS) system specifications and conceptual design

    Science.gov (United States)

    Han, D.; Salomonson, V.; Ormsby, J.; Ardanuy, P.; Mckay, A.; Hoyt, D.; Jaffin, S.; Vallette, B.; Sharts, B.; Folta, D.

    1988-01-01

    The MODIS Information, Data, and Control System (MIDACS) Specifications and Conceptual Design Document discusses system level requirements, the overall operating environment in which requirements must be met, and a breakdown of MIDACS into component subsystems, which include the Instrument Support Terminal, the Instrument Control Center, the Team Member Computing Facility, the Central Data Handling Facility, and the Data Archive and Distribution System. The specifications include sizing estimates for the processing and storage capacities of each data system element, as well as traffic analyses of data flows between the elements internally, and also externally across the data system interfaces. The specifications for the data system, as well as for the individual planning and scheduling, control and monitoring, data acquisition and processing, calibration and validation, and data archive and distribution components, do not yet fully specify the data system in the complete manner needed to achieve the scientific objectives of the MODIS instruments and science teams. The teams have not yet been formed; however, it was possible to develop the specifications and conceptual design based on the present concept of EosDIS, the Level-1 and Level-2 Functional Requirements Documents, the Operations Concept, and through interviews and meetings with key members of the scientific community.

  10. Analysis of Design Basis Events in a Preliminary Specific Design of PGSFR

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Kwi Lim; Ha, Kwi Seok [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2014-05-15

    KAERI(Korea Atomic Energy Research Institute) has been developing a preliminary specific design of the PGSFR(Prototype Gen-IV Sodium-cooled Fast Reactor), which is a pool type sodium cooled fast reactor with a thermal power of 392.2 MW. Many alterations were made on a preliminary specific design of the PGSFR compared with a conceptual design: a heat removal capability of the DHRS was decreased, the DHXs were submerged in a cold pool, a pressure drop through the core was increased, and a shape of a redon was changed to a peanut type, etc. For identification of safety characteristics including the design changes, 5 DBE's(Design Bases Events) were analyzed using MARS-LMR code. The representative DBE's are TOP(Transient of Over Power), LOF(Loss Of Flow), LOHS(Loss Of Heat Sink), Reactor Vessel Leak and Pipe Break accidents. The representative DBE's were analyzed using the MARS-LMR code. As a result, it was identified that the PGSFR were appropriately tripped by the RPS(Reactor Protection System) and cooled by the DHRS. But a high cladding temperature was estimated in a pipe break accident. Therefore, integrity of the structure should be evaluated in the further study.

  11. Design Reconstitution Program Plan and procedures for K Basins

    Energy Technology Data Exchange (ETDEWEB)

    Laney, T.

    1995-01-12

    This document establishes a systematic program to establish, organize, and document the design basis and design requirement information for the K Basins where existing design information is inadequate. The Design Reconstitution Program involves identifying and retrieving design information from identified source documents; evaluating, verifying, and validating the design information; resolving discrepancies; regenerating missing critical design information; and preparing and issuing a summary document of the design information. Upon completion, the design requirements shall be evaluated with the facility as-found configuration to verify the adequacy of appropriate design requirements with the as-found configuration and to document and resolve any discovered discrepancies. Once the design requirement (design analysis, calculation, design basis) comparison is made and discrepancies resolved (dispositioned, implemented, and incorporated as required), the as-found condition of a drawing then becomes an as-built drawing that is released into the engineering release system. This as-built drawing is then the accurate accounting of the field configuration that is consistent with the design requirements (recovered through the design reconstitution program) and is used with high confidence to make valid engineering, operational, and maintenance decisions.

  12. Examining pre-service science teachers' developing pedagogical design capacity for planning and supporting task-based classroom discussions

    Science.gov (United States)

    Ross, Danielle Kristina

    Teachers face many challenges as we move forward into the age of the Next Generation Science Standards (NGSS) (Achieve, Inc., 2013). The NGSS aim to develop a population of scientifically literate and talented students who can participate in the "innovation-driven economy" (p. 1). In order to meet these goals, teachers must provide students with opportunities to engage in science and engineering practices (SEPs) and learn core ideas of these disciplines. This study followed pre-service secondary science teachers as they participated in a secondary science teacher preparation program intended to support the development of their pedagogical design capacity (Brown, 2009) related to planning and supporting whole-class taskbased discussions. Teacher educators in this program designed an intervention that aimed in supporting this development. This study examined a particular dimension of PDC -- specifically, PSTs effective use of resources to plan science lessons in which students engage in a high demand task, participate in SEPs, and discuss their work in a whole-class setting. In order to examine the effectiveness of the intervention, I had to define PDC a priori. I measured PDC by documenting how/whether PSTs engaged in the following instructional planning practices: developing Learning Goals, selecting and/or designing challenging tasks, anticipating student thinking, planning for monitoring student thinking, imagining the discussion storyline, planning questions, and planning marking strategies. Analyses showed a significant difference between baseline lesson plan scores and Instructional Performance scores. These findings suggest these patterns and changes were directly linked to the teacher preparation program. The mean increase in Instructional Performance scores during the course of the teacher preparation year further supports the effect of the teacher preparation coursework. Pre-service teachers with high pedagogical design capacity continually integrated the

  13. Measurement of Spray Drift with a Specifically Designed Lidar System.

    Science.gov (United States)

    Gregorio, Eduard; Torrent, Xavier; Planas de Martí, Santiago; Solanelles, Francesc; Sanz, Ricardo; Rocadenbosch, Francesc; Masip, Joan; Ribes-Dasi, Manel; Rosell-Polo, Joan R

    2016-04-08

    Field measurements of spray drift are usually carried out by passive collectors and tracers. However, these methods are labour- and time-intensive and only provide point- and time-integrated measurements. Unlike these methods, the light detection and ranging (lidar) technique allows real-time measurements, obtaining information with temporal and spatial resolution. Recently, the authors have developed the first eye-safe lidar system specifically designed for spray drift monitoring. This prototype is based on a 1534 nm erbium-doped glass laser and an 80 mm diameter telescope, has scanning capability, and is easily transportable. This paper presents the results of the first experimental campaign carried out with this instrument. High coefficients of determination (R² > 0.85) were observed by comparing lidar measurements of the spray drift with those obtained by horizontal collectors. Furthermore, the lidar system allowed an assessment of the drift reduction potential (DRP) when comparing low-drift nozzles with standard ones, resulting in a DRP of 57% (preliminary result) for the tested nozzles. The lidar system was also used for monitoring the evolution of the spray flux over the canopy and to generate 2-D images of these plumes. The developed instrument is an advantageous alternative to passive collectors and opens the possibility of new methods for field measurement of spray drift.

  14. LARES: A New Satellite Specifically Designed for Testing General Relativity

    Directory of Open Access Journals (Sweden)

    Antonio Paolozzi

    2015-01-01

    Full Text Available It is estimated that today several hundred operational satellites are orbiting Earth while many more either have already reentered the atmosphere or are no longer operational. On the 13th of February 2012 one more satellite of the Italian Space Agency has been successfully launched. The main difference with respect to all other satellites is its extremely high density that makes LARES not only the densest satellite but also the densest known orbiting object in the solar system. That implies that the nongravitational perturbations on its surface will have the smallest effects on its orbit. Those design characteristics are required to perform an accurate test of frame dragging and specifically a test of Lense-Thirring effect, predicted by General Relativity. LARES satellite, although passive, with 92 laser retroreflectors on its surface, was a real engineering challenge in terms of both manufacturing and testing. Data acquisition and processing are in progress. The paper will describe the scientific objectives, the status of the experiment, the special feature of the satellite and separation system including some manufacturing issues, and the special tests performed on its retroreflectors.

  15. Revisiting software specification and design for large astronomy projects

    Science.gov (United States)

    Wiant, Scott; Berukoff, Steven

    2016-07-01

    The separation of science and engineering in the delivery of software systems overlooks the true nature of the problem being solved and the organization that will solve it. Use of a systems engineering approach to managing the requirements flow between these two groups as between a customer and contractor has been used with varying degrees of success by well-known entities such as the U.S. Department of Defense. However, treating science as the customer and engineering as the contractor fosters unfavorable consequences that can be avoided and opportunities that are missed. For example, the "problem" being solved is only partially specified through the requirements generation process since it focuses on detailed specification guiding the parties to a technical solution. Equally important is the portion of the problem that will be solved through the definition of processes and staff interacting through them. This interchange between people and processes is often underrepresented and under appreciated. By concentrating on the full problem and collaborating on a strategy for its solution a science-implementing organization can realize the benefits of driving towards common goals (not just requirements) and a cohesive solution to the entire problem. The initial phase of any project when well executed is often the most difficult yet most critical and thus it is essential to employ a methodology that reinforces collaboration and leverages the full suite of capabilities within the team. This paper describes an integrated approach to specifying the needs induced by a problem and the design of its solution.

  16. Planning and Design of Water Resources Systems Under Climate Change and Variability

    Science.gov (United States)

    Strzepek, K. M.

    2014-12-01

    Regional and local water supplies and demands are impacted by global and national systems: climate, economics, population and energy as well as policies: development, energy, and environmental. These drivers can result in complex interactions that require deeper understanding in order to provide actionable information for water planners and stakeholders to develop strategic plans in the face of a changing and growing world. To add more complexity to this issue is the fact that all these drivers are uncertain and the type of uncertainty is not the same. This talk will address approaches to Water Resource Planning at sub-national water regions, national levels and trans-boundary river basins under a non-stationary hydro-climatic future. Additionally the talk will address the design of specific water resource projects such as reservoirs and hydroplants that are being designed now but will operate far in the future when the hydro-climatology will be very different. Examples will be drawn from recent work in Africa, Eastern Europe and Central Asia, and North America and some insights and outstanding questions will be presented.

  17. Strategic by Design: Iterative Approaches to Educational Planning

    Science.gov (United States)

    Chance, Shannon

    2010-01-01

    Linear planning and decision-making models assume a level of predictability that is uncommon today. Such models inadequately address the complex variables found in higher education. When academic organizations adopt paired-down business strategies, they restrict their own vision. They fail to harness emerging opportunities or learn from their own…

  18. Strategic by Design: Iterative Approaches to Educational Planning

    Science.gov (United States)

    Chance, Shannon

    2010-01-01

    Linear planning and decision-making models assume a level of predictability that is uncommon today. Such models inadequately address the complex variables found in higher education. When academic organizations adopt paired-down business strategies, they restrict their own vision. They fail to harness emerging opportunities or learn from their own…

  19. Educational Trends Shaping School Planning, Design, Construction, Funding and Operation

    Science.gov (United States)

    Stevenson, Kenneth R.

    2010-01-01

    What does the future hold for educators and facilities professionals when it comes to planning, building, funding, and operating school facilities? No one can absolutely know beforehand. However, there are many, many indicators of where public education in the United States may well be destined. These indicators take the form of already occurring…

  20. An online planning tool for designing terrace layouts

    Science.gov (United States)

    A web-based conservation planning tool, WebTERLOC (web-based Terrace Location Program), was developed to provide multiple terrace layout options using digital elevation model (DEM) and geographic information systems (GIS). Development of a terrace system is complicated by the time-intensive manual ...

  1. Design tool for offshore wind farm cluster planning

    DEFF Research Database (Denmark)

    Hasager, Charlotte Bay; Madsen, Peter Hauge; Giebel, Gregor

    2015-01-01

    an investigation of the wake influence between dual operation twin farms was possible. Furthermore both micro- and mesoscale wake models have been compared to satellite-based wind farm wake data in the North Sea. Regarding the planning of the electrical grid, both inter-array and long-distance cables were modelled...

  2. Solid Waste Operations Complex W-113, Detail Design Report (Title II). Volume 3: Specifications

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-09-01

    The Solid Waste Retrieval Facility--Phase 1 (Project W113) will provide the infrastructure and the facility required to retrieve from Trench 04, Burial ground 4C, contact handled (CH) drums and boxes at a rate that supports all retrieved TRU waste batching, treatment, storage, and disposal plans. This includes (1) operations related equipment and facilities, viz., a weather enclosure for the trench, retrieval equipment, weighing, venting, obtaining gas samples, overpacking, NDE, NDA, shipment of waste and (2) operations support related facilities, viz., a general office building, a retrieval staff change facility, and infrastructure upgrades such as supply and routing of water, sewer, electrical power, fire protection, roads, and telecommunication. Title I design for the operations related equipment and facilities was performed by Raytheon/BNFL, and that for the operations support related facilities including infrastructure upgrade was performed by KEH. These two scopes were combined into an integrated W113 Title II scope that was performed by Raytheon/BNFL. Volume 3 is a compilation of the construction specifications that will constitute the Title II materials and performance specifications. This volume contains CSI specifications for non-equipment related construction material type items, performance type items, and facility mechanical equipment items. Data sheets are provided, as necessary, which specify the equipment overall design parameters.

  3. Applying Quality Function Deployment in Industrial Design Curriculum Planning

    Science.gov (United States)

    Liu, Shuo-Fang; Lee, Yann-Long; Lin, Yi-Zhi; Tseng, Chien-Feng

    2013-01-01

    Industrial design is a discipline that combines multiple professional fields. Enterprise demands for industrial design competencies also change over time; thus, the curriculum of industrial design education should be compatible with the current demands of the industry. However, scientific approaches have not been previously employed to plan…

  4. Applying Quality Function Deployment in Industrial Design Curriculum Planning

    Science.gov (United States)

    Liu, Shuo-Fang; Lee, Yann-Long; Lin, Yi-Zhi; Tseng, Chien-Feng

    2013-01-01

    Industrial design is a discipline that combines multiple professional fields. Enterprise demands for industrial design competencies also change over time; thus, the curriculum of industrial design education should be compatible with the current demands of the industry. However, scientific approaches have not been previously employed to plan…

  5. Effective strategy making: Co-designing scenarios as a tool for effective strategic planning

    Directory of Open Access Journals (Sweden)

    Jan Vogelij

    2015-08-01

    making together a product and collaboration towards a strategy, defined as a common exploration of possibilities. The interactions of the participants in the strategy making process, potentially creating trust and enhancing social cohesion, may be more important than the resulting concept for a development strategy. Therefore our attention focused on the way strategies are made in the black box of specific processes. The interactions aiming at co-ownership and collaboration are central in this novel ’interactions approach’.The resulting strategy does not necessarily contain (infra structural projects; a spatial strategy concerns a selected localised policy and argumentative framework for future development.Societal relevanceBeing a planning consultant with over forty years of experience in practice, the author highly values practical applicability in society. Understanding of practice-related factors for effectiveness of strategy making is important because effective public management saves costs for society; a framework expressing the aimed-for direction of development provides clarity for private initiatives; an agreed strategy helps to coordinate sector policies; several EU and national subsidies for projects require a locally agreed structural frame.Because a development vision concerns the direction of an envisaged development, its effectiveness is defined in terms of performance of the argumentative framework based on the story lines developed in the discussions during the strategy making process. Our search aims at identifying recommendations for enhanced chances for performing strategies in praxis.ApproachA theoretical frame was composed based on literature in the fields of planning theory, policy analysis and design. Research questions were formulated concerning the importance of the process related variables: open process management, coownership, co-design, the application of scenarios and visualizations. Concerning the importance of the place related

  6. Phase Startup Initiative Phases 3 and 4 Test Plan and Test Specification ( OCRWM)

    Energy Technology Data Exchange (ETDEWEB)

    PAJUNEN, A.L.; LANGEVIN, M.J.

    2000-08-07

    Construction for the Spent Nuclear Fuel (SNF) Project facilities is continuing per the Level III Baseline Schedule, and installation of the Fuel Retrieval System (FRS) and Integrated Water Treatment System (IWTS) in K West Basin is now complete. In order to accelerate the project, a phased start up strategy to initiate testing of the FRS and IWTS early in the overall project schedule was proposed (Williams 1999). Wilkinson (1999) expands the definition of the original proposal into four functional testing phases of the Phased Startup Initiative (PSI). Phases 1 and 2 are based on performing functional tests using dummy fuel. This test plan provides overall guidance for Phase 3 and 4 tests, which are performed using actual irradiated N fuel assemblies. The overall objective of the Phase 3 and 4 testing is to verify how the FRS and IWTS respond while processing actual fuel. Conducting these tests early in the project schedule will allow identification and resolution of equipment and process problems before they become activities on the start-up critical path. The specific objectives of this test plan are to: Define the Phase 3 and 4 test scope for the FRS and IWTS; Provide detailed test requirements that can be used to write the specific test procedures; Define data required and measurements to be taken. Where existing methods to obtain these do not exist, enough detail will be provided to define required additional equipment; and Define specific test objectives and acceptance criteria.

  7. High Specification Offshore Blades: Work Package: 1B: Blades Design

    OpenAIRE

    Brown, Richard; Fletcher, Timothy; Galbraith, Roderick; York, Christopher

    2008-01-01

    This report outlines the current state of the art in offshore wind turbine blade aerodynamic design, along with the key technical limitations and possible technologies which may improve the aerodynamic design of blades and turbine rotors in the future. It is suggested that there are three principal areas in which aerodynamic improvements can be made to the design of offshore wind turbine systems: improved rotor system and blade tip design for operation at higher tip speeds, optimisation of wi...

  8. Exploiting Linkage Information and Problem-Specific Knowledge in Evolutionary Distribution Network Expansion Planning.

    Science.gov (United States)

    Luong, Ngoc Hoang; Poutré, Han La; Bosman, Peter A N

    2017-04-07

    This article tackles the Distribution Network Expansion Planning (DNEP) problemthat has to be solved by distribution network operators to decide which, where, and/or when enhancements to electricity networks should be introduced to satisfy the future power demands. Because of many real-world details involved, the structure of the problem is not exploited easily using mathematical programming techniques, for which reason we consider solving this problem with evolutionary algorithms (EAs). We compare three types of EAs for optimizing expansion plans: the classic genetic algorithm (GA), the estimation-of-distribution algorithm (EDA), and the Gene-pool Optimal Mixing Evolutionary Algorithm (GOMEA). Not fully knowing the structure of the problem, we study the effect of linkage learning through the use of three linkage models: univariate, marginal product, and linkage tree. We furthermore experiment with the impact of incorporating different levels of problem-specific knowledge in the variation operators. Experiments show that the use of problem-specific variation operators is far more important for the classic GA to find high-quality solutions. In all EAs, the marginal product model and its linkage learning procedure have difficulty in capturing and exploiting the DNEP problemstructure. GOMEA, especiallywhen combined with the linkage tree structure, is found to have the most robust performance by far, even when an out-of-the-box variant is used that does not exploit problem-specific knowledge. Based on experiments, we suggest that when selecting optimization algorithms for power system expansion planning problems, EAs that have the ability to effectively model and efficiently exploit problem structures, such as GOMEA, should be given priority, especially in the case of black-box or grey-box optimization.

  9. Urban Planning and Management Information Systems Analysis and Design Based on GIS

    Science.gov (United States)

    Xin, Wang

    Based on the analysis of existing relevant systems on the basis of inadequate, after a detailed investigation and research, urban planning and management information system will be designed for three-tier structure system, under the LAN using C/S mode architecture. Related functions for the system designed in accordance with the requirements of the architecture design of the functional relationships between the modules. Analysis of the relevant interface and design, data storage solutions proposed. The design for small and medium urban planning information system provides a viable building program.

  10. A Cultural Heritage, Preservation Master Plan: Postoccupancy of Emporion to Evaluate Theme Park versus Environmental Design

    OpenAIRE

    Saura Carulla, Magdalena

    2012-01-01

    In spite of market pragmatics, the urban, architectural and environmental protection and conservation ideas of the Emporion master plan were quickly implemented in actual planning. (1) Previous research conducted at Technical University of Catalonia set the design requirements for policy-making required in any sort of master plan. One of the goals was to predict a successful use of space through a natural and historic lanscapes. Social and cultural factors determined one set of parameters for...

  11. Design of Logistics Route Planning for Printing Enterprises Based on Baidu Map

    Directory of Open Access Journals (Sweden)

    Da Zhong-Yue

    2017-01-01

    Full Text Available As traditional printing industry is facing fierce competition in the market and logistics becomes a new sources of growth, the traditional printing enterprises want to build and improve their logistics system. So in this paper, the author has designed the logistics planning system based on the Baidu map development kit. It has the function of route planning and location tracking. This system meet the printing enterprise logistics route planning and tracking demand.

  12. Bayes factor design analysis: Planning for compelling evidence.

    Science.gov (United States)

    Schönbrodt, Felix D; Wagenmakers, Eric-Jan

    2017-03-01

    A sizeable literature exists on the use of frequentist power analysis in the null-hypothesis significance testing (NHST) paradigm to facilitate the design of informative experiments. In contrast, there is almost no literature that discusses the design of experiments when Bayes factors (BFs) are used as a measure of evidence. Here we explore Bayes Factor Design Analysis (BFDA) as a useful tool to design studies for maximum efficiency and informativeness. We elaborate on three possible BF designs, (a) a fixed-n design, (b) an open-ended Sequential Bayes Factor (SBF) design, where researchers can test after each participant and can stop data collection whenever there is strong evidence for either [Formula: see text] or [Formula: see text], and (c) a modified SBF design that defines a maximal sample size where data collection is stopped regardless of the current state of evidence. We demonstrate how the properties of each design (i.e., expected strength of evidence, expected sample size, expected probability of misleading evidence, expected probability of weak evidence) can be evaluated using Monte Carlo simulations and equip researchers with the necessary information to compute their own Bayesian design analyses.

  13. Cooperative Planning, Uncertainty, and Managerial Control in Concurrent Design

    OpenAIRE

    Victoria L. Mitchell; Barrie R. Nault

    2007-01-01

    We examine whether cooperative planning and uncertainty affect the magnitude of rework in concurrent engineering projects with upstream and downstream operations, and explore the impact of such rework on project delays. Using survey data from a sample of 120 business process (BP) redesign and related information technology (IT) development projects in healthcare and telecommunications, our results indicate that upstream (BP) rework and downstream (IT) rework is mediated and mitigated by coope...

  14. How can we better plan for the unplanned? Designing and operating more robust public transport systems

    NARCIS (Netherlands)

    Cats, O.

    2015-01-01

    Traditionally, transport systems have been designed to perform well under normal conditions assuming that everything works as planned. As anyone that uses public transport can testify, deviations from planning are a recurrent phenomenon. Investments in public transport are therefore increasingly mot

  15. Reliability-Based Optimal Design of Experiment Plans for Offshore Structures

    DEFF Research Database (Denmark)

    Sørensen, John Dalsgaard; Faber, M. H.; Kroon, I. B.

    1993-01-01

    Design of cost optimal experiment plans on the basis of a preposterior analysis is discussed. In particular the planning of on-site response measurements on offshore structures in order to update probabilistic models for fatigue life estimation is addressed. Special emphasis is given to modelling...

  16. Smoking-specific communication and children's smoking onset: an extension of the theory of planned behaviour.

    Science.gov (United States)

    Hiemstra, Marieke; Otten, Roy; van Schayck, Onno C P; Engels, Rutger C M E

    2012-01-01

    The aim of this study was to test whether maternal smoking-specific communication and parental smoking related to smoking cognitions (i.e. attitude, self-efficacy and social norm) derived from the Theory of Planned Behaviour in association with smoking onset during preadolescence. A total of 1478 pairs of mothers and children participated (mean age: 10.11; standard deviation = 0.78). Structural equation models in Mplus were used to examine whether smoking-specific communication influences children's smoking cognitions, which in turn, affect smoking onset. A positive association was found between pro-smoking attitudes and smoking onset. Smoking-specific communication and parental smoking were related to smoking cognitions. Specifically, frequency of communication was negatively associated with pro-smoking attitudes, social norms of mother and best friend. Quality of communication related negatively to pro-smoking attitudes and positively to self-efficacy and norms of friends. Parental smoking was positively associated with pro-smoking attitudes and norms of mother and (best) friends. Additionally, more frequent communication and higher levels of parental smoking were associated with higher smoking onset. In conclusion, smoking-specific communication and parental smoking were associated with smoking cognitions and smoking onset. Already during preadolescence, parents contribute to shaping the smoking cognitions of their children, which may be predictive of smoking later in life.

  17. 75 FR 27944 - Approval and Promulgation of Implementation Plans; Designation of Areas for Air Quality Planning...

    Science.gov (United States)

    2010-05-19

    ... Air Quality Planning Purposes; State of California; PM-10; Determination of Attainment for the Coso... determination that the Coso Junction nonattainment area (CJNA) has attained the 24-hour National Ambient Air... monitoring data for the PM-10 NAAQS from 2006-2008. In addition, reported data in EPA's Air Quality System...

  18. Implementation Plan for Chemical Industry R&D Roadmap for Nanomaterials by Design

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2006-04-01

    The purpose of this effort is to develop an implementation plan to realize the vision and goals identified in the Chemical Industry R&D Roadmap for Nanomaterials By Design: From Fundamentals to Function.

  19. Revising the South African guidelines for human settlement planning and design (the red book)

    CSIR Research Space (South Africa)

    Van Niekerk, Willemien

    2015-11-01

    Full Text Available The Guidelines for Human Settlement Planning and Design, commonly known as the Red Book, is a South African publication aimed at providing practical guidance to built environment professionals in support of the creation of sustainable and vibrant...

  20. The Virtual and the Real in Planning and Urban Design: Perspectives, Practices and Applications

    NARCIS (Netherlands)

    Yamu, Claudia; Poplin, Alenka; Devisch, Oswald; de Roo, Gert

    2017-01-01

    The Virtual and the Real: Perspectives, Practices and Applications for the Built Environment explores the merging relationship between physical and virtual spaces in planning and urban design. Technological advances such as smart sensors, interactive screens, locative media and evolving computation

  1. Guidelines for the integrated planning and design of underground coal mines.

    CSIR Research Space (South Africa)

    Fourie, GA

    2001-11-01

    Full Text Available Mine planning and design involves the compilation and integration of all relevant geological, geotechnical, mining, engineering and economic data into a single document to define and describe the exploitation strategy for a particular mineral...

  2. The Virtual and the Real in Planning and Urban Design: Perspectives, Practices and Applications

    NARCIS (Netherlands)

    Yamu, Claudia; Poplin, Alenka; Devisch, Oswald; de Roo, Gert

    2017-01-01

    The Virtual and the Real: Perspectives, Practices and Applications for the Built Environment explores the merging relationship between physical and virtual spaces in planning and urban design. Technological advances such as smart sensors, interactive screens, locative media and evolving computation

  3. Design verification and validation plan for the cold vacuum drying facility

    Energy Technology Data Exchange (ETDEWEB)

    NISHIKAWA, L.D.

    1999-06-03

    The Cold Vacuum Drying Facility (CVDF) provides the required process systems, supporting equipment, and facilities needed for drying spent nuclear fuel removed from the K Basins. This document presents the both completed and planned design verification and validation activities.

  4. Planned Missing Data Designs in Educational Psychology Research

    NARCIS (Netherlands)

    Rhemtulla, M.; Hancock, G.R.

    2016-01-01

    Although missing data are often viewed as a challenge for applied researchers, in fact missing data can be highly beneficial. Specifically, when the amount of missing data on specific variables is carefully controlled, a balance can be struck between statistical power and research costs. This articl

  5. Libraries for Schools and Universities. Design & Planning Series.

    Science.gov (United States)

    Wild, Friedemann

    This document is one part of a series intended to provide modern pattern books for architects and planners in need of practical solutions to specific problems. Each volume in the series is concerned with structures built for a specific purpose and contains several dozen projects, none more than a few years old, that are good examples of such…

  6. Designing for user experiences in specific contexts: contributions from contextmapping

    NARCIS (Netherlands)

    Schifferstein, H.N.J.; Sleeswijk Visser, F.

    2013-01-01

    In saturated consumer markets, consumer choices often depend on subtle product differences that contribute positively to their user experiences. Hence, it is important for designers to be able to create products that elicit different experiences. In this chapter we discuss a design approach that tak

  7. Specific Cooperative Analysis and Design in General Hypermedia Development

    DEFF Research Database (Denmark)

    Grønbæk, Kaj; Mogensen, Preben Holst

    1994-01-01

    Cooperative analysis and design is often considered only to be applicable in settings where a system is being developed solely for the ‘user’ participants in the process. This paper, however, argues that there are quite good prospects in applying cooperative analysis and design techniques in spec...

  8. 33 CFR 154.1225 - Specific response plan development and evaluation criteria and other requirements for fixed...

    Science.gov (United States)

    2010-07-01

    ... development and evaluation criteria and other requirements for fixed facilities that handle, store, or... MATERIAL IN BULK Response Plans for Animal Fats and Vegetable Oils Facilities § 154.1225 Specific response plan development and evaluation criteria and other requirements for fixed facilities that handle,...

  9. The future of the IMS Learning Design specification: a critical look

    NARCIS (Netherlands)

    Sloep, Peter

    2009-01-01

    P. B. Sloep (2009). The future of the IMS Learning Design specification: a critical look. Presentation at the IMS Learning Design seminar 'The future of IMS Learning Design'. December, 10, 2009, Wollongong, Australia: University of Wollongong.

  10. Iteration in instructional design : an empirical study on the specification of training simulators

    NARCIS (Netherlands)

    Verstegen, D.M.L.

    2004-01-01

    Instructional design and development methods prescribe how specifications for advanced instructional products, such as training simulators, should be designed. In practice, however, the design process is disturbed by many 'pragmatic' factors, such as conflicting constraints, interference from manage

  11. Iteration in instructional design : an empirical study on the specification of training simulators

    NARCIS (Netherlands)

    Verstegen, D.M.L.

    2004-01-01

    Instructional design and development methods prescribe how specifications for advanced instructional products, such as training simulators, should be designed. In practice, however, the design process is disturbed by many 'pragmatic' factors, such as conflicting constraints, interference from manage

  12. The future of the IMS Learning Design specification: a critical look

    NARCIS (Netherlands)

    Sloep, Peter

    2009-01-01

    P. B. Sloep (2009). The future of the IMS Learning Design specification: a critical look. Presentation at the IMS Learning Design seminar 'The future of IMS Learning Design'. December, 10, 2009, Wollongong, Australia: University of Wollongong.

  13. [Dementia-friendly hospital wards : Expert recommendations for planning and design].

    Science.gov (United States)

    Büter, K; Motzek, T; Dietz, B; Hofrichter, L; Junge, M; Kopf, D; von Lützau-Hohlbein, H; Traxler, S; Zieschang, T; Marquardt, G

    2017-01-01

    Hospitals face great challenges in the necessity of providing care for the rising number of elderly patients with dementia. The adaptation of the spatial environment represents an important component to improve the care situation of patients with dementia. For more than 30 years research results from long-term care have provided evidence on the therapeutic effect of numerous architectural features on people with dementia. Due to specific medical and organizational requirements in hospitals, the transferability of these findings is, however, limited. An interdisciplinary workshop with experts from the fields of medicine, nursing, gerontology, self-help and architecture was conducted in July 2015. Based on existing research findings and experiences from pilot projects, the spatial requirements for dementia-friendly hospital wards were collated, suggested solutions were discussed from different perspectives and finally design recommendations were derived. The article gives a first comprehensive overview of architectural measures that are required for the design of dementia-friendly hospital wards. The recommendations provided range from architectural criteria, such as the size and spatial structure of hospital wards, to interior design elements, including orientation and navigation aids and the use of light and colors. Furthermore, information about the planning process are given.

  14. Study on Design Specifications and Wear Behavior of MCC

    Institute of Scientific and Technical Information of China (English)

    ZHU Shou-xing; ZHU Shi-gen

    2006-01-01

    Main design parameters of MCC (metallic card clothing)which include front angle, base width, tooth pitch, and tooth point dimensions are discussed to investigate the carding effect of MCC. Experimental results show that type C machine has the best carding effect, which is not ascribed to single factor control but the integrated design optimization and good performance of wire teeth. In comparison with the teeth design, the wire performance is another important factor that influences the performance of modern high efficient production carding machine.

  15. Artefact specification, design, and production as a process of communication

    DEFF Research Database (Denmark)

    Galle, Per

    1999-01-01

    for the success of communication carry over to the artefact production process. The purpose of the analysis is to provide a conceptual background for the study of various aspects of artefact production, such as design, or the development of computer-based tools for collaborative design, product modelling......The co-operative process of specifying, designing, and producing an artefact is analysed in terms of communication among the agents involved. By way of introduction, I offer a brief analysis of communication in general, outlining conditions for its success, while avoiding simplistic assumptions...

  16. Specification and development of choreography fragments for a choreography designer

    OpenAIRE

    Schilling, Joas

    2014-01-01

    This thesis specifies choreography fragments. Also the process of extracting them from an existing choreography as well as importing them into another choreography is defined. Then these choreography fragments are implemented for a choreography designer, that was written by Oliver Sonnauer. The implementation also connects the choreography designer with a repository for fragments called Fragmento, which can be used to version, share and reuse fragments easily.

  17. IMS Learning Design Specification (version 1.0)

    NARCIS (Netherlands)

    Koper, Rob; Olivier, Bill; Anderson, Thor

    2003-01-01

    Information Model is the core document with the actual specification, the other documents and schema's are derived from the Information Model. When you see any inconsistency between documents, look at the Information Model for the correct interpretation.

  18. FEL Design Studies at LBNL: Activities and Plans

    Energy Technology Data Exchange (ETDEWEB)

    Corlett, John N.; Fawley, W.; Lidia, S.; Padmore, H.; Penn, G.; Pogorelov, I.; Qiang, J.; Sannibale, F.; Staples, J.; Steier, C.; Venturini, M.; Wan, W.; Wilcox, R.; Zholents, A.

    2007-03-01

    LBNL staff are currently pursuing R&D for future x-ray FELs, and participate in two FEL construction projects. Our strategy is to address the most fundamental challenges, which are the cost-drivers and performance limitations of FEL facilities. An internally funded R&D program is aimed at investigating accelerator physics and technologies in three key areas: (1) Theoretical study, modeling, and experimental development of low emittance, high quantum efficiency cathodes; (2) Design studies of electron beam delivery systems, including emittance manipulations, high-resolution modeling of 6-D phase space, and low-emittance beam transport; and (3) Design studies of optical manipulations of electron beams for seeded and SASE FELs, providing short x-ray pulses of variable duration, synchronous with the seed and pump laser sources, and also long transform-limited pulses with a narrow bandwidth. Design studies of means for production of attosecond x-ray pulses at various wavelengths. We are collaborators in the FERMI{at}Elettra seeded FEL facility under construction at Sincrotrone Trieste, Italy, participating in accelerator design and FEL physics studies, and mechanical and electrical engineering. We are participating in the LCLS project at SLAC, implementing our design of stabilized timing and synchronization systems. Here we outline our long-term objectives, and current activities.

  19. Comparison of a Restricted and Unrestricted Vegan Diet Plan with a Restricted Omnivorous Diet Plan on Health-Specific Measures

    OpenAIRE

    Richard J. Bloomer; Gunnels, Trint A; Schriefer, JohnHenry M.

    2015-01-01

    Background: We have previously noted beneficial health outcomes when individuals follow a dietary restriction plan in accordance with the Daniel Fast (DF). This is true whether individuals eliminate all animal products or include small amounts of meat and dairy in their plan. The present study sought to compare anthropometric and biochemical measures of health in individuals following a traditional DF (i.e., restricted vegan) or modified DF (i.e., restricted omnivorous; inclusive of ad libitu...

  20. Designing Lesson Plan Based on Critical Thinking for Language Classes

    Directory of Open Access Journals (Sweden)

    Norwanto Norwanto

    2016-07-01

    Full Text Available Critical thinking includes a process of reasoning in thinking as stated by some scholars. In the process, there is universal standard to follow: clarity, accuracy, precision, relevance, depth, breadth, logic, and fairness. In language classes, critical thinking creates active classes. To bring critical thinking to classes, Bloom’s Taxonomy and critical thinking strategies can be working definition in order critical thinking to be applied to pedagogical materials in a practical way. Steps for critical thinking teaching includes five steps: (1 determining learning objectives, (2 teaching through questioning, (3 practicing before assessing, (4 reviewing, refining, and improving, and (5 providing feedback and assessment of learning. A lesson plan should reflect these five steps.

  1. Workspace experiments: a journey on planning participatory design

    DEFF Research Database (Denmark)

    Souza da Conceição, Carolina; Broberg, Ole

    2017-01-01

    resource material with its prototypes and thus mediate communication among the different participants of the process, content and format being gradually developed through participation. Results: The result was a flexible resource material for designers as a tool to help building a participatory process...

  2. The Effectiveness of Self-regulatory Speech Training for Planning and Problem Solving in Children with Specific Language Impairment.

    Science.gov (United States)

    Abdul Aziz, Safiyyah; Fletcher, Janet; Bayliss, Donna M

    2016-08-01

    Self-regulatory speech has been shown to be important for the planning and problem solving of children. Our intervention study, including comparisons to both wait-list and typically developing controls, examined the effectiveness of a training programme designed to improve self-regulatory speech, and consequently, the planning and problem solving performance of 87 (60 males, 27 females) children aged 4-7 years with Specific Language Impairment (SLI) who were delayed in their self-regulatory speech development. The self-regulatory speech and Tower of London (TOL) performance of children with SLI who received the intervention initially or after a waiting period was compared with that of 80 (48 male, 32 female) typically developing children who did not receive any intervention. Children were tested at three time points: Time 1- prior to intervention; Time 2 - after the first SLI group had received training and the second SLI group provided a wait-list control; and Time 3 - when the second SLI group had received training. At Time 1 children with SLI produced less self-regulatory speech and were impaired on the TOL relative to the typically developing children. At Time 2, the TOL performance of children with SLI in the first training group improved significantly, whereas there was no improvement for the second training group (the wait-list group). At Time 3, the second training group improved their TOL performance and the first group maintained their performance. No significant differences in TOL performance were evident between typically developing children and those with SLI at Time 3. Moreover, decreases in social speech and increases in inaudible muttering following self-regulatory speech training were associated with improvements in TOL performance. Together, the results show that self-regulatory speech training was effective in increasing self-regulatory speech and in improving planning and problem solving performance in children with SLI.

  3. Electromagnetic sunscreen model: design of experiments on particle specifications.

    Science.gov (United States)

    Lécureux, Marie; Deumié, Carole; Enoch, Stefan; Sergent, Michelle

    2015-10-01

    We report a numerical study on sunscreen design and optimization. Thanks to the combined use of electromagnetic modeling and design of experiments, we are able to screen the most relevant parameters of mineral filters and to optimize sunscreens. Several electromagnetic modeling methods are used depending on the type of particles, density of particles, etc. Both the sun protection factor (SPF) and the UVB/UVA ratio are considered. We show that the design of experiments' model should include interactions between materials and other parameters. We conclude that the material of the particles is a key parameter for the SPF and the UVB/UVA ratio. Among the materials considered, none is optimal for both. The SPF is also highly dependent on the size of the particles.

  4. Formal design specification of a Processor Interface Unit

    Science.gov (United States)

    Fura, David A.; Windley, Phillip J.; Cohen, Gerald C.

    1992-01-01

    This report describes work to formally specify the requirements and design of a processor interface unit (PIU), a single-chip subsystem providing memory-interface bus-interface, and additional support services for a commercial microprocessor within a fault-tolerant computer system. This system, the Fault-Tolerant Embedded Processor (FTEP), is targeted towards applications in avionics and space requiring extremely high levels of mission reliability, extended maintenance-free operation, or both. The need for high-quality design assurance in such applications is an undisputed fact, given the disastrous consequences that even a single design flaw can produce. Thus, the further development and application of formal methods to fault-tolerant systems is of critical importance as these systems see increasing use in modern society.

  5. Power Supply System for the Atlas Experiment: Design Specifications, Implementation, Test and First Results

    Science.gov (United States)

    Lazzaroni, M.; Citterio, M.; Latorre, S.; Lanza, A.; Cova, P.; Delmonte, N.; Giuliani, F.

    2014-06-01

    The planned upgrade of instrumentation sensitivity in the ATLAS experiment of the Large Hadron Collider (LHC), at CERN, calls for a new type of power distribution architecture. Moreover, power supplies require DC-DC power converters able to work in very hostile environment and maintaining high level of Reliability, Availability, Maintainability and Safety (denoted as RAMS requirements) during the experimental activity. Two main issues need to be discussed: first, electronic devices and equipment must operate in very high background of both charged and neutral particles and high static magnetic field and, second, the increase of the radiation background and the requirements of new front-end electronics are indeed incompatible with the current capability of the actual distribution system. The APOLLO R&D collaboration, funded by the Italian Istituto Nazionale di Fisica Nucleare (INFN), aims to study dedicated topologies of both distribution system and DC-DC power converters and to design, build and test demonstrators, developing the needed technology for the industrialization phase. The collaboration has designed a 3kW, 280V-12V converter (MC) based on the Switch in Line architecture (SIL), a DC to DC phase-shifted converter characterized by a disposition in line of the MOSFETs with good soft switching performances, and in the last year many steps have been taken to enhance the power dissipation and the reliability and to improve the general features of the designed converter. In particular a new water heat sink was designed on the basis of TFD simulation accounting for the layout of the specific converter. Experimental activities in order to characterize both thermal and electrical features of the MC confirm the correctness of the adopted design criteria.

  6. Automated Tactical Symbology System (TACSYM): System Design Specifications

    Science.gov (United States)

    1984-03-01

    138. Personal Demand 39. Microphones 89. CBR 139. Repair Parts 40. Target Designator 90. Chemical 140. Wire 41. Visual Station 91. Combined Arms...allmi for modification of the database. Insertion and removal of data from the database is controlled by DATABsE . C. 2.1.4 Software Suppot t. The

  7. Tissue-specific designs of stem cell hierarchies

    NARCIS (Netherlands)

    Visvader, Jane E; Clevers, Hans

    Recent work in the field of stem cell biology suggests that there is no single design for an adult tissue stem cell hierarchy, and that different tissues employ distinct strategies to meet their self-renewal and repair requirements. Stem cells may be multipotent or unipotent, and can exist in

  8. Tissue-specific designs of stem cell hierarchies

    NARCIS (Netherlands)

    Visvader, Jane E; Clevers, Hans

    2016-01-01

    Recent work in the field of stem cell biology suggests that there is no single design for an adult tissue stem cell hierarchy, and that different tissues employ distinct strategies to meet their self-renewal and repair requirements. Stem cells may be multipotent or unipotent, and can exist in quiesc

  9. Discussion on the application of planning management to urban planning design%谈规划管理对城市规划设计的影响

    Institute of Scientific and Technical Information of China (English)

    廉东涛

    2015-01-01

    概述了城市规划管理和城市规划设计的意义,分析了城市规划管理的发展趋势,从规划设计目标、规划原则、用地管理、社会功能等方面,探讨了城市规划管理对规划设计的影响,可促进城市经济和建设的不断发展。%This paper summarized the significance of urban planning management and urban planning design,analyzed the development trend of urban planning management,from planning design target,planning principles,land management,social function and other aspects,discussed the influence of urban planning management to planning design,could promote the continuous development of urban economy and construction.

  10. The ILC Beam Delivery System - Conceptual Design and RD Plans

    Energy Technology Data Exchange (ETDEWEB)

    Seryi, Andrei; /SLAC

    2005-05-27

    The Beam Delivery System of the ILC has many stringent and sometimes conflicting requirements. To produce luminosity, the beams must be focused to nanometer size. To provide acceptable detector backgrounds, particles far from the beam core must be collimated. Unique beam diagnostics and instrumentation are required to monitor parameters of the colliding beams such as the energy spectrum and polarization. The detector and beamline components must be protected against errant beams. After collision, the beams must also be transported to the beam dumps safely and with acceptable losses. An international team is actively working on the design of the ILC Beam Delivery System in close collaboration. Details of the design, recent progress and remaining challenges will be summarized in this paper.

  11. Languages for Specific Purposes. Program Design and Evaluation.

    Science.gov (United States)

    Mackay, Ronald, Ed.; Palmer, Joe Darwin, Ed.

    This collection of research on curriculum and program development in languages for special purposes (LSP) contains the following papers: (1) "LSP Curriculum Development--From Policy to Practice," by Ronald Mackay and Maryse Bosquet; (2) "The Problem of Needs Assessment in English for Specific Purposes: Some Theoretical and Practical…

  12. The new autonomous house: design and planning for sustainability

    Energy Technology Data Exchange (ETDEWEB)

    Vale, Brenda; Vale, Robert

    2000-07-01

    This book describes the philosophy, design and construction of a 4-bedroom residence in the British Midlands without mains water or sewerage, but with the means to produce power from the sun and the wind, and the facilities to collect drinking-water from the rain. The New Autonomous House has a simple but revolutionary message -- that it is possible to live in a home which is inexpensive, kind to the planet, and which liberates its owner from utility bills. (Author)

  13. Designing a Strategic Plan through an Emerging Knowledge Generation Process: The ATM Experience

    Science.gov (United States)

    Zanotti, Francesco

    2012-01-01

    Purpose: The aim of this contribution is to describe a new methodology for designing strategic plans and how it was implemented by ATM, a public transportation agency based in Milan, Italy. Design/methodology/approach: This methodology is founded on a new system theory, called "quantum systemics". It is based on models and metaphors both…

  14. 75 FR 62026 - Approval and Promulgation of Implementation Plans and Designation of Areas for Air Quality...

    Science.gov (United States)

    2010-10-07

    ... under subpart 1, based upon their 8-hour ambient air quality design values. Knox County (which is a part... are attained if the design value is 0.084 ppm or below. The data must be collected and quality-assured... for Air Quality Planning Purposes; Tennessee; Redesignation of the Knoxville 8-Hour...

  15. Planned Missing Data Designs for Spline Growth Models in Salivary Cortisol Research

    NARCIS (Netherlands)

    Hogue, C.M.; Pornprasertmanit, S.; Fry, M.D.; Rhemtulla, M.; Little, T.D.

    2013-01-01

    Salivary cortisol is often used as an index of physiological and psychological stress in exercise science and psychoneuroendocrine research. A primary concern when designing research studies examining cortisol stems from the high cost of analysis. Planned missing data designs involve intentionally o

  16. Designing a Strategic Plan through an Emerging Knowledge Generation Process: The ATM Experience

    Science.gov (United States)

    Zanotti, Francesco

    2012-01-01

    Purpose: The aim of this contribution is to describe a new methodology for designing strategic plans and how it was implemented by ATM, a public transportation agency based in Milan, Italy. Design/methodology/approach: This methodology is founded on a new system theory, called "quantum systemics". It is based on models and metaphors both…

  17. Planned Missing Data Designs for Spline Growth Models in Salivary Cortisol Research

    Science.gov (United States)

    Hogue, Candace M.; Pornprasertmanit, Sunthud; Fry, Mary D.; Rhemtulla, Mijke; Little, Todd D.

    2013-01-01

    Salivary cortisol is often used as an index of physiological and psychological stress in exercise science and psychoneuroendocrine research. A primary concern when designing research studies examining cortisol stems from the high cost of analysis. Planned missing data designs involve intentionally omitting a random subset of observations from data…

  18. Planned Missing Data Designs for Spline Growth Models in Salivary Cortisol Research

    Science.gov (United States)

    Hogue, Candace M.; Pornprasertmanit, Sunthud; Fry, Mary D.; Rhemtulla, Mijke; Little, Todd D.

    2013-01-01

    Salivary cortisol is often used as an index of physiological and psychological stress in exercise science and psychoneuroendocrine research. A primary concern when designing research studies examining cortisol stems from the high cost of analysis. Planned missing data designs involve intentionally omitting a random subset of observations from data…

  19. Facility Planning and Curriculum Design--The Impact of Environment on Teaching and Learning.

    Science.gov (United States)

    Niece, Richard

    1988-01-01

    Facility planning and curriculum design, key ingredients of effective schooling, should complement one another. The open-classroom concept failed because of poor coordination between facility design and instructional practice. Aesthetic qualities of learning environments express certain values and affect teacher energy and student creativity.…

  20. An Agent-based Strategy for Deploying Analysis Models into Specification and Design for Distributed APS Systems

    CERN Document Server

    de Santa-Eulalia, Luis Antonio; Frayret, Jean-Marc

    2011-01-01

    Despite the extensive use of the agent technology in the Supply Chain Management field, its integration with Advanced Planning and Scheduling (APS) tools still represents a promising field with several open research questions. Specifically, the literature falls short in providing an integrated framework to analyze, specify, design and implement simulation experiments covering the whole simulation cycle. Thus, this paper proposes an agent-based strategy to convert the 'analysis' models into 'specification' and 'design' models combining two existing methodologies proposed in the literature. The first one is a recent and unique approach dedicated to the 'analysis' of agent-based APS systems. The second one is a well-established methodological framework to 'specify' and 'design' agent-based supply chain systems. The proposed conversion strategy is original and is the first one allowing simulation analysts to integrate the whole simulation development process in the domain of distributed APS.

  1. Environmental Management Waste Management Facility (EMWMF) Site-Specific Health and Safety Plan, Oak Ridge, Tennessee

    Energy Technology Data Exchange (ETDEWEB)

    Flynn, N.C. Bechtel Jacobs

    2008-04-21

    The Bechtel Jacobs Company LLC (BJC) policy is to provide a safe and healthy workplace for all employees and subcontractors. The implementation of this policy requires that operations of the Environmental Management Waste Management Facility (EMWMF), located one-half mile west of the U.S. Department of Energy (DOE) Y-12 National Security Complex, be guided by an overall plan and consistent proactive approach to environment, safety and health (ES&H) issues. The BJC governing document for worker safety and health, BJC/OR-1745, 'Worker Safety and Health Program', describes the key elements of the BJC Safety and Industrial Hygiene (IH) programs, which includes the requirement for development and implementation of a site-specific Health and Safety Plan (HASP) where required by regulation (refer also to BJC-EH-1012, 'Development and Approval of Safety and Health Plans'). BJC/OR-1745, 'Worker Safety and Health Program', implements the requirements for worker protection contained in Title 10 Code of Federal Regulations (CFR) Part 851. The EMWMF site-specific HASP requirements identifies safe operating procedures, work controls, personal protective equipment, roles and responsibilities, potential site hazards and control measures, site access requirements, frequency and types of monitoring, site work areas, decontamination procedures, and outlines emergency response actions. This HASP will be available on site for use by all workers, management and supervisors, oversight personnel and visitors. All EMWMF assigned personnel will be briefed on the contents of this HASP and will be required to follow the procedures and protocols as specified. The policies and procedures referenced in this HASP apply to all EMWMF operations activities. In addition the HASP establishes ES&H criteria for the day-to-day activities to prevent or minimize any adverse effect on the environment and personnel safety and health and to meet standards that define acceptable

  2. A review of design issues specific to hypersonic flight vehicles

    Science.gov (United States)

    Sziroczak, D.; Smith, H.

    2016-07-01

    This paper provides an overview of the current technical issues and challenges associated with the design of hypersonic vehicles. Two distinct classes of vehicles are reviewed; Hypersonic Transports and Space Launchers, their common features and differences are examined. After a brief historical overview, the paper takes a multi-disciplinary approach to these vehicles, discusses various design aspects, and technical challenges. Operational issues are explored, including mission profiles, current and predicted markets, in addition to environmental effects and human factors. Technological issues are also reviewed, focusing on the three major challenge areas associated with these vehicles: aerothermodynamics, propulsion, and structures. In addition, matters of reliability and maintainability are also presented. The paper also reviews the certification and flight testing of these vehicles from a global perspective. Finally the current stakeholders in the field of hypersonic flight are presented, summarizing the active programs and promising concepts.

  3. Reprogrammable Controller Design From High-Level Specification

    Directory of Open Access Journals (Sweden)

    M. Benmohammed

    2003-10-01

    Full Text Available Existing techniques in high-level synthesis mostly assume a simple controller architecture model in the form of a single FSM. However, in reality more complex controller architectures are often used. On the other hand, in the case of programmable processors, the controller architecture is largely defined by the available control-flow instructions in the instruction set. With the wider acceptance of behavioral synthesis, the application of these methods for the design of programmable controllers is of fundamental importance in embedded system technology. This paper describes an important extension of an existing architectural synthesis system targeting the generation of ASIP reprogrammable architectures. The designer can then generate both style of architecture, hardwired and programmable, using the same synthesis system and can quickly evaluate the trade-offs of hardware decisions.

  4. Implementation and Deployment of the IMS Learning Design Specification

    Directory of Open Access Journals (Sweden)

    Gilbert Paquette

    2005-06-01

    Full Text Available Knowledge management in organizations, the learning objects paradigm, the advent of a new web generation, and the “Semantic Web” are major actual trends that reveal a potential for a renewed distance learning pedagogy. First and foremost is the use of educational modelling languages and instructional engineering methods to help decide how to aggregate learning objects in learning and knowledge management environments. This article proposes a set of tools under implementation, such as a graphic Learning Design Editor and a delivery system, using learning object repositories to create IMS-LD online environments. We also propose a strategy for the deployment of learning design tools and methods in learning organizations.

  5. Rational design of a triple helix-specific intercalating ligand.

    Science.gov (United States)

    Escudé, C; Nguyen, C H; Kukreti, S; Janin, Y; Sun, J S; Bisagni, E; Garestier, T; Hélène, C

    1998-03-31

    DNA triple helices offer new perspectives toward oligonucleotide-directed gene regulation. However, the poor stability of some of these structures might limit their use under physiological conditions. Specific ligands can intercalate into DNA triple helices and stabilize them. Molecular modeling and thermal denaturation experiments suggest that benzo[f]pyrido[3, 4-b]quinoxaline derivatives intercalate into triple helices by stacking preferentially with the Hoogsteen-paired bases. Based on this model, it was predicted that a benzo[f]quino[3,4-b]quinoxaline derivative, which possesses an additional aromatic ring, could engage additional stacking interactions with the pyrimidine strand of the Watson-Crick double helix upon binding of this pentacyclic ligand to a triplex structure. This compound was synthesized. Thermal denaturation experiments and inhibition of restriction enzyme cleavage show that this new compound can indeed stabilize triple helices with great efficiency and specificity and/or induce triple helix formation under physiological conditions.

  6. Computer Aided Control System Design Using Frequency Domain Specifications

    Science.gov (United States)

    1976-06-01

    the algorithm to check for satisfaction of these particular specifications as the compensator parameters are varied. 25 Ill- TJE MINIMIZATION TECHNIQUE...used in this work was developed originally ty M. J. Eox, [4], and is capable of finding the tinimum cf a general nonlinear cost function, composed of...repeatedly if necessary, halfway in tcward the centroid of the ether already accepted vertices, until ultimately a feasible point is found. Continued

  7. DATA MANAGEMENT PLANNING IN ENGINEERING DESIGN AND MANUFACTURING RESEARCH

    DEFF Research Database (Denmark)

    Darlington, Mansur; Howard, Thomas J.; Ball, Alex

    2011-01-01

    There is a growing interest in maximizing the value of research data through their sharing and re-use. This desire is hampered by the prevailing culture in data management during the research activity which largely ignores the potential for re-use, and by a lack of understanding of the character...... of research data and of the barriers to and opportunities for their re-use. The work reported here characterizes engineering design and manufacture research data and explores the context of their development and current management. Insights from the work have resulted in the authors proposing a number of new...... approaches and tools which provide the basis for better management practice....

  8. DATA MANAGEMENT PLANNING IN ENGINEERING DESIGN AND MANUFACTURING RESEARCH

    DEFF Research Database (Denmark)

    Darlington, Mansur; Howard, Thomas J.; Ball, Alex;

    2011-01-01

    There is a growing interest in maximizing the value of research data through their sharing and re-use. This desire is hampered by the prevailing culture in data management during the research activity which largely ignores the potential for re-use, and by a lack of understanding of the character...... of research data and of the barriers to and opportunities for their re-use. The work reported here characterizes engineering design and manufacture research data and explores the context of their development and current management. Insights from the work have resulted in the authors proposing a number of new...... approaches and tools which provide the basis for better management practice....

  9. NASIS data base management system - IBM 360/370 OS MVT implementation. 4: Program design specifications

    Science.gov (United States)

    1973-01-01

    The design specifications for the programs and modules within the NASA Aerospace Safety Information System (NASIS) are presented. The purpose of the design specifications is to standardize the preparation of the specifications and to guide the program design. Each major functional module within the system is a separate entity for documentation purposes. The design specifications contain a description of, and specifications for, all detail processing which occurs in the module. Sub-modules, reference tables, and data sets which are common to several modules are documented separately.

  10. Internet plan and planning

    Directory of Open Access Journals (Sweden)

    Kahriman Emina

    2008-01-01

    Full Text Available Paper discuss specific features of internet plan as well as planning as management process in general in the contemporary environment. No need to stress out that marketing plan and marketing planning is core activity in approaching to market. At the same time, there are a lot specific c request in preparing marketing plan comparing to business planning due to marketing plan is an essential part. The importance of internet plan and planning rely on specific features of the internet network but as a part of general corporate as well as marketing strategy.

  11. AUTMOD3: The Integration of Design and Planning Tools for Automatic Modular Construction

    Directory of Open Access Journals (Sweden)

    Ramiro Diez

    2008-11-01

    Full Text Available Europe is facing a fast growing need for affordable, high quality housing, which can not be solved by means of traditional or conventional building technology and its associated methods of construction. One of the solutions to this problem is the application of high quality modular construction, which defines a new building process as the assembly of pre-fabricated modules in the construction site. As part of this philosophy, AUTMOD3 is an automatic modular construction software environment, developed in the frame of the EU project FutureHome. The system seamlessly integrates architectural design, planning and simulation tools in a wellknown CAD program commonly used by designers. Architectural design using previously defined 3D and 2D modules or modularisation of the traditional building design are the main objectives of the AUTMOD3 design tool. The production planning and the on-site modular assembly planning are the main task to be performed by the planning tool. The AUTMOD3 assembly planning tool generates the trajectories, which can be applied directly to a robotized crane develop in the project FutureHome.

  12. 14 CFR 91.705 - Operations within airspace designated as Minimum Navigation Performance Specification Airspace.

    Science.gov (United States)

    2010-01-01

    ... Minimum Navigation Performance Specification Airspace. 91.705 Section 91.705 Aeronautics and Space FEDERAL... Operations within airspace designated as Minimum Navigation Performance Specification Airspace. (a) Except as... airspace designated as Minimum Navigation Performance Specifications airspace unless— (1) The aircraft...

  13. Search for efficient complete and planned missing data designs for analysis of change.

    Science.gov (United States)

    Wu, Wei; Jia, Fan; Rhemtulla, Mijke; Little, Todd D

    2016-09-01

    The design of longitudinal data collection is an essential component of any study of change. A well-designed study will maximize the efficiency of statistical tests and minimize the cost of available resources (e.g., budget). Two families of designs have been used to collect longitudinal data: complete data (CD) and planned missing (PM) designs. This article proposes a systematic and flexible procedure named SEEDMC (SEarch for Efficient Designs using Monte Carlo Simulation) to search for efficient CD and PM designs for growth-curve modeling under budget constraints. This procedure allows researchers to identify efficient designs for multiple effects separately and simultaneously, and designs that are robust to MCAR attrition. SEEDMC is applied to identify efficient designs for key change parameters in linear and quadratic growth models. The identified efficient designs are summarized and the strengths and possible extensions of SEEDMC are discussed.

  14. Bridging the Planning Gap: Linking Conceptual Army Design to Military Decision-Making

    Science.gov (United States)

    2011-05-19

    art, French postmodern philosophy, social sciences, psychology, architecture , urban planning, and…ancient Chinese military thinking.” For this...bringing two “separate but closely related” activities together is not limited to architecture alone. 2 Understanding the history of detailed and...Design,” 10. 96 Bryan Lawson, How Designers Think: The Design Process Demystified, 4th Ed., (Boston MA: Architectural Press, 2006), 109. 44 If

  15. Plečnik’s plans for the design of Novi trg

    Directory of Open Access Journals (Sweden)

    Andreja Jan

    1994-01-01

    Full Text Available Plečnik’s rearrangement of the centre of Ljubljana is a process, which had already begun in the time of his journey to Italy. The process developed alongside the architectural and urban design plan. The planning of Novi trg (New market as an important public place shows the development of an architectural idea trough a long period by which a space was monumentalized and idea connections with the city found.

  16. Path Specific Register Design to Reduce Standby Power Consumption

    Directory of Open Access Journals (Sweden)

    Emre Salman

    2011-04-01

    Full Text Available A methodology is proposed to design low leakage registers by considering the type of timing path, i.e., short or long, and type of register, i.e., launching or capturing. Three different dual threshold voltage registers are developed where each register trades, depending upon the timing path, a different timing constraint for reducing the leakage current. For example, the first proposed register is used as a launching register in a noncritical path, trading clock-to-Q delay for leakage current. Other timing constraints such as setup and hold times are maintained the same not to introduce any timing violations. Alternatively, the second and third registers, trade, respectively, setup time and hold time for leakage current while maintaining clock-to-Q delay constant. The effect of the proposed methodology on leakage current is investigated for four technology nodes. The overall reduction in the leakage current of a register can exceed 90% while maintaining the clock frequency and other design parameters such as area and dynamic power the same. Three ISCAS 89 benchmark circuits are utilized to evaluate the methodology, demonstrating, on average, 23% reduction in the overall leakage current.

  17. Planning a World Wide Web based design computer system supporting a collaborative design process

    DEFF Research Database (Denmark)

    Sørensen, Lars Schiøtt

    1996-01-01

    An early planning of a WWW-based CAD-system is the major of this publication. Different approaches are discussed and the final "solution" for the system is described in a general way.......An early planning of a WWW-based CAD-system is the major of this publication. Different approaches are discussed and the final "solution" for the system is described in a general way....

  18. Planning a World Wide Web based design computer system supporting a collaborative design process

    DEFF Research Database (Denmark)

    Sørensen, Lars Schiøtt

    1996-01-01

    An early planning of a WWW-based CAD-system is the major of this publication. Different approaches are discussed and the final "solution" for the system is described in a general way.......An early planning of a WWW-based CAD-system is the major of this publication. Different approaches are discussed and the final "solution" for the system is described in a general way....

  19. The HAL 9000 Space Operating System Real-Time Planning Engine Design and Operations Requirements

    Science.gov (United States)

    Stetson, Howard; Watson, Michael D.; Shaughnessy, Ray

    2012-01-01

    In support of future deep space manned missions, an autonomous/automated vehicle, providing crew autonomy and an autonomous response planning system, will be required due to the light time delays in communication. Vehicle capabilities as a whole must provide for tactical response to vehicle system failures and space environmental effects induced failures, for risk mitigation of permanent loss of communication with Earth, and for assured crew return capabilities. The complexity of human rated space systems and the limited crew sizes and crew skills mix drive the need for a robust autonomous capability on-board the vehicle. The HAL 9000 Space Operating System[2] designed for such missions and space craft includes the first distributed real-time planning / re-planning system. This paper will detail the software architecture of the multiple planning engine system, and the interface design for plan changes, approval and implementation that is performed autonomously. Operations scenarios will be defined for analysis of the planning engines operations and its requirements for nominal / off nominal activities. An assessment of the distributed realtime re-planning system, in the defined operations environment, will be provided as well as findings as it pertains to the vehicle, crew, and mission control requirements needed for implementation.

  20. Exemplary Design Envelope Specification for Standard Modular Hydropower Technology

    Energy Technology Data Exchange (ETDEWEB)

    Witt, Adam M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Smith, Brennan T. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Tsakiris, Achilleas [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Univ. of Tennessee, Knoxville, TN (United States); Papanicolaou, Thanos [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Univ. of Tennessee, Knoxville, TN (United States); Pries, Jason L. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Burress, Timothy A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Stewart, Kevin M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Lee, Kyutae [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); DeNeale, Scott T. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Bevelhimer, Mark S. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Pracheil, Brenda M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); McManamay, Ryan A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Ekici, Kivanc [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Univ. of Tennessee, Knoxville, TN (United States); Kutz, Benjamin [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Univ. of Tennessee, Knoxville, TN (United States); Curd, Shelaine L. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Bishop, Norm [Knight Piesold, Denver, CO (United States); Welch, Tim [U.S. Department of Energy (DOE), Washington, DC (United States). Office of Energy Efficiency and Renewable Energy (EERE); Rabon, Daniel [U.S. Department of Energy (DOE), Washington, DC (United States). Office of Energy Efficiency and Renewable Energy (EERE); Fernandez, Alisha [McKeown and Associates, Moberly, MO (United States)

    2017-02-01

    Hydropower is an established, affordable renewable energy generation technology supplying nearly 18% of the electricity consumed globally. A hydropower facility interacts continuously with the surrounding water resource environment, causing alterations of varying magnitude in the natural flow of water, energy, fish, sediment, and recreation upstream and downstream. A universal challenge in facility design is balancing the extraction of useful energy and power system services from a stream with the need to maintain ecosystem processes and natural environmental function. On one hand, hydroelectric power is a carbon-free, renewable, and flexible asset to the power system. On the other, the disruption of longitudinal connectivity and the artificial barrier to aquatic movement created by hydraulic structures can produce negative impacts that stress fresh water environments. The growing need for carbon-free, reliable, efficient distributed energy sources suggests there is significant potential for hydropower projects that can deploy with low installed costs, enhanced ecosystem service offerings, and minimal disruptions of the stream environment.

  1. Rational Design of CXCR4 Specific Antibodies with Elongated CDRs

    Science.gov (United States)

    2015-01-01

    The bovine antibody (BLV1H12) which has an ultralong heavy chain complementarity determining region 3 (CDRH3) provides a novel scaffold for antibody engineering. By substituting the extended CDRH3 of BLV1H12 with modified CXCR4 binding peptides that adopt a β-hairpin conformation, we generated antibodies specifically targeting the ligand binding pocket of CXCR4 receptor. These engineered antibodies selectively bind to CXCR4 expressing cells with binding affinities in the low nanomolar range. In addition, they inhibit SDF-1-dependent signal transduction and cell migration in a transwell assay. Finally, we also demonstrate that a similar strategy can be applied to other CDRs and show that a CDRH2-peptide fusion binds CXCR4 with a Kd of 0.9 nM. This work illustrates the versatility of scaffold-based antibody engineering and could greatly expand the antibody functional repertoire in the future. PMID:25041362

  2. The Run-2 ATLAS Trigger System: Design, Performance and Plan

    CERN Document Server

    zur Nedden, Martin; The ATLAS collaboration

    2016-01-01

    In high-energy physics experiments, online selection is crucial to select interesting collisions from the large data volume. The ATLAS experiment at the Large Hadron Collider (LHC) utilizes the trigger system that consists of a hardware Level-1 (L1) and a software based high-level trigger (HLT), reducing the event rate from the design bunch-crossing rate of 40 MHz to an average recording rate of about 1000 Hz. The ATLAS trigger has been successfully collecting collision data during the first run of the LHC (Run-1) between 2009-2013 at a centre-of-mass energy between 900 GeV and 8 TeV. In the second run of LHC (Run-2) starting from 2015, the LHC operates at centre-of-mass energy of 13 TeV and provides a higher luminosity of collisions. Also, the number of collisions occurring in a same bunch crossing increases. The ATLAS trigger system has to cope with these challenges, while maintaining or even improving the efficiency to select relevant physics processes. In this talk, first we will review the ATLAS trigger ...

  3. The Run-2 ATLAS Trigger System: Design, Performance and Plan

    CERN Document Server

    zur Nedden, Martin; The ATLAS collaboration

    2016-01-01

    In high-energy physics experiments, online selection is crucial to select interesting collisions from the large data volume. The ATLAS experiment at the Large Hadron Collider (LHC) utilizes the trigger system that consists of a hardware Level-1 (L1) and a software based high-level trigger (HLT), reducing the event rate from the design bunch-crossing rate of 40 MHz to an average recording rate of about 1000 Hz. In the LHC Run-2 starting from in 2015, the LHC operates at centre-of-mass energy of 13 TeV providing a luminosity up to $1.2 \\cdot 10^{34} {\\rm cm^{-2}s^{-1}}$. The ATLAS trigger system has to cope with these challenges, while maintaining or even improving the efficiency to select relevant physics processes. In this paper, the ATLAS trigger system for LHC Run-2 is reviewed. Secondly, the impressive performance improvements in the HLT trigger algorithms used to identify leptons, hadrons and global event quantities like missing transverse energy is shown. Electron, muon and photon triggers covering trans...

  4. Comparison of a Restricted and Unrestricted Vegan Diet Plan with a Restricted Omnivorous Diet Plan on Health-Specific Measures

    Directory of Open Access Journals (Sweden)

    Richard J. Bloomer

    2015-07-01

    Full Text Available Background: We have previously noted beneficial health outcomes when individuals follow a dietary restriction plan in accordance with the Daniel Fast (DF. This is true whether individuals eliminate all animal products or include small amounts of meat and dairy in their plan. The present study sought to compare anthropometric and biochemical measures of health in individuals following a traditional DF (i.e., restricted vegan or modified DF (i.e., restricted omnivorous; inclusive of ad libitum meat and skim milk consumption, with those following an unrestricted vegan diet plan. Methods: 35 subjects (six men; 29 women; 33 ± 2 years; range: 18–67 years completed a 21-day diet plan. Subjects reported to the lab for pre- (day 1 and post-intervention testing (day 22 in a 10 h fasted state. Blood samples were collected and assayed for complete blood count, metabolic panel, lipid panel, insulin, HOMA-IR, C-reactive protein, and oxidative stress biomarkers (malondialdehyde, advanced oxidation protein products, and nitrate/nitrite. Heart rate and blood pressure were measured and body composition was determined via dual energy X-ray absorptiometry. Subjects’ self-reported compliance, mental and physical health, and satiety in relation to the dietary modification were recorded. Results: No interaction effects were noted for our outcome measures (p > 0.05. However, subjects in the traditional DF group reported an approximate 10% increase in perceived mental and physical health, with a 25% reduction in malondialdehyde and a 33% reduction in blood insulin. Systolic BP was reduced approximately 7 mmHg in subjects assigned to the traditional DF, with an approximate 5 mmHg reduction in subjects assigned to the modified DF and the unrestricted vegan plan. A small (2 mmHg reduction in diastolic BP was noted for subjects in both DF groups; a slight increase in diastolic BP was noted for subjects assigned to the unrestricted vegan group. An approximate 20

  5. Comparison of a Restricted and Unrestricted Vegan Diet Plan with a Restricted Omnivorous Diet Plan on Health-Specific Measures.

    Science.gov (United States)

    Bloomer, Richard J; Gunnels, Trint A; Schriefer, JohnHenry M

    2015-07-14

    We have previously noted beneficial health outcomes when individuals follow a dietary restriction plan in accordance with the Daniel Fast (DF). This is true whether individuals eliminate all animal products or include small amounts of meat and dairy in their plan. The present study sought to compare anthropometric and biochemical measures of health in individuals following a traditional DF (i.e., restricted vegan) or modified DF (i.e., restricted omnivorous; inclusive of ad libitum meat and skim milk consumption), with those following an unrestricted vegan diet plan. 35 subjects (six men; 29 women; 33 ± 2 years; range: 18-67 years) completed a 21-day diet plan. Subjects reported to the lab for pre- (day 1) and post-intervention testing (day 22) in a 10 h fasted state. Blood samples were collected and assayed for complete blood count, metabolic panel, lipid panel, insulin, HOMA-IR, C-reactive protein, and oxidative stress biomarkers (malondialdehyde, advanced oxidation protein products, and nitrate/nitrite). Heart rate and blood pressure were measured and body composition was determined via dual energy X-ray absorptiometry. Subjects' self-reported compliance, mental and physical health, and satiety in relation to the dietary modification were recorded. No interaction effects were noted for our outcome measures (p > 0.05). However, subjects in the traditional DF group reported an approximate 10% increase in perceived mental and physical health, with a 25% reduction in malondialdehyde and a 33% reduction in blood insulin. Systolic BP was reduced approximately 7 mmHg in subjects assigned to the traditional DF, with an approximate 5 mmHg reduction in subjects assigned to the modified DF and the unrestricted vegan plan. A small (2 mmHg) reduction in diastolic BP was noted for subjects in both DF groups; a slight increase in diastolic BP was noted for subjects assigned to the unrestricted vegan group. An approximate 20% reduction was noted in total and LDL cholesterol

  6. Psychosocial Risks Generated By Assets Specific Design Software

    Science.gov (United States)

    Remus, Furtună; Angela, Domnariu; Petru, Lazăr

    2015-07-01

    The human activity concerning an occupation is resultant from the interaction between the psycho-biological, socio-cultural and organizational-occupational factors. Tehnological development, automation and computerization that are to be found in all the branches of activity, the level of speed in which things develop, as well as reaching their complexity, require less and less physical aptitudes and more cognitive qualifications. The person included in the work process is bound in most of the cases to come in line with the organizational-occupational situations that are specific to the demands of the job. The role of the programmer is essencial in the process of execution of ordered softwares, thus the truly brilliant ideas can only come from well-rested minds, concentrated on their tasks. The actual requirements of the jobs, besides the high number of benefits and opportunities, also create a series of psycho-social risks, which can increase the level of stress during work activity, especially for those who work under pressure.

  7. Reflecting through the designing: a brief analysis of the teacher’s planning process

    Directory of Open Access Journals (Sweden)

    Francesca Anello

    2017-01-01

    Full Text Available The aim of this work is to study the conditions in which teachers plan and execute educational actions in the classroom and to find out which difficulties they encountered during the development of the planned teaching action. The “concrete operations” that 15 teachers in the Palermo area had accomplished, were highlighted before, during and after every structured activity to promote the pupils’ oral expression. Specifically, the research, which is collocated in the case study, had the function of verifying forty descriptors. These were grouped in the five cardinal points of the ADDIE model (Analysis, Design, Development, Implementation, Evaluation, with a motivated group of teachers that were formed during the action-research. To check intentions and behaviors of teachers, tools for self-analysis were built, individual notes and shared reports of the practice were used. The teachers found that the proposed projected device, initially, designed with 40 descriptors was not practical and chose only 20 of these. A simplified and flexible model is now available for the didactical preparation of the activities.Riflettere attraverso la progettazione: breve analisi del processo di programmazione didattica dell’insegnanteL’obiettivo del contributo è indagare le condizioni in cui gli insegnanti pianificano e realizzano un intervento in classe, e quali difficoltà incontrano nelle fasi di sviluppo dell’azione didattica programmata. Sono state evidenziate le “operazioni concrete” che 15 insegnanti del territorio di Palermo hanno compiuto prima, durante e dopo un’attività strutturata per promuovere negli alunni l’espressione orale. Nello specifico la ricerca, che si colloca nella tipologia dello studio di caso, si è occupata di verificare la funzionalità di 40 descrittori, raggruppati nei cinque punti cardine del modello ADDIE (Analysis, Design, Development, Implementation, Evaluation, con un gruppo motivato di insegnanti che si

  8. Nez Perce Tribal Hatchery Project : Combined-Planning & Design and Operations & Maintenance Reports, 2000 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Larson, Roy Edward; Walker, Grant W.

    2002-12-31

    Nez Perce Tribal Hatchery (NPTH) Year-2000 Combined Maintenance and Operations (O&M) and Planning and Design (P&D) contract is hereby completed based on this annual report patterned after the Statement of Work (SOW) for the project as contracted with Bonneville Power Administration. Primary project activities focused on completion of the Northwest Power Planning Council Step-3 process that: (1) Accepted final design, (2) Authorized a capital construction amount of $16,050,000, and (3) Authorized contractor selection, and (4) Provided construction site dedication, and (5) Implemented construction activities over an anticipated 2-year period of July 2000 through October 2002.

  9. Application of the PRECEDE-PROCEED Planning Model in Designing an Oral Health Strategy.

    Science.gov (United States)

    Binkley, Catherine J; Johnson, Knowlton W

    2013-11-01

    Although the poor oral health of adults with intellectual and developmental disabilities (IDD) constitutes a significant health disparity in the United States, few interventions to date have produced lasting results. Moreover, there is minimal application of planning models to inform and design a theory-based strategy that has the potential to be effective and sustainable in this population. The PRECEDE-PROCEED planning model is being used to design and evaluate an oral health strategy for adults with IDD. The PRECEDE component involves assessing social, epidemiological, behavioral, environmental, educational, and ecological factors that informed the development of an intervention with underlying social cognitive theory assumptions. The PROCEED component consists of pilot-testing and evaluating the implementation of the strategy, its impact on mediators and outcomes of the population under study. A The PRECEDE assessment and strategy design results are presented including a conceptual framework and oral health strategy that are linked to social cognitive theory and Health Action Process Approach. We have developed a strategy consisting of a planned actions, capacity building, environmental adaptations, and caregiver reinforcement within group homes. The strategy is designed to increase caregiver self-efficacy, outcome expectancies, and behavioral capability, and also to create environmental influences that will lead to improved self-care behavior of the adult with IDD. It is anticipated that this strategy will improve the oral health and quality of life, including respiratory health, of individuals with IDD. The planned PROCEED component of the planning model includes a description of an in-process pilot study to refine the oral health strategy, along with a future randomized controlled clinical trial to demonstrate its effectiveness. The application of the PRECEDE-PROCEED planning model presented here demonstrates the feasibility of this planning model for

  10. Empowering the Design and the Sharing of Learning Plans by Means of Net Technologies: The IAMEL System

    Science.gov (United States)

    Bottino, Rosa Maria; Ott, Michela; Tavella, Mauro

    This paper reports on the research work carried out by the authors in the framework of the IAMEL project, supported by the Italian Ministry of Education. The project was mainly aimed at enhancing the teaching/learning of mathematics by providing teachers with specific e-learning platforms endowed with a number of dedicated tools supporting the setting-up and the carrying-out of specific in-field experiments. One of the main results of the project was the development of a methodology to carry out the design of educational interventions; such a methodology was based on a conceptual goal-oriented framework and on different authoring tools among which the IAMEL system, an online tool fully described in the paper that allows both the production and the sharing of pedagogical plans and consents the design and the modeling of educational interventions with different levels of granularity and scope.

  11. De novo design of protein homo-oligomers with modular hydrogen bond network-mediated specificity

    Science.gov (United States)

    Boyken, Scott E.; Chen, Zibo; Groves, Benjamin; Langan, Robert A.; Oberdorfer, Gustav; Ford, Alex; Gilmore, Jason; Xu, Chunfu; DiMaio, Frank; Pereira, Jose Henrique; Sankaran, Banumathi; Seelig, Georg; Zwart, Peter H.; Baker, David

    2017-01-01

    In nature, structural specificity in DNA and proteins is encoded quite differently: in DNA, specificity arises from modular hydrogen bonds in the core of the double helix, whereas in proteins, specificity arises largely from buried hydrophobic packing complemented by irregular peripheral polar interactions. Here we describe a general approach for designing a wide range of protein homo-oligomers with specificity determined by modular arrays of central hydrogen bond networks. We use the approach to design dimers, trimers, and tetramers consisting of two concentric rings of helices, including previously not seen triangular, square, and supercoiled topologies. X-ray crystallography confirms that the structures overall, and the hydrogen bond networks in particular, are nearly identical to the design models, and the networks confer interaction specificity in vivo. The ability to design extensive hydrogen bond networks with atomic accuracy is a milestone for protein design and enables the programming of protein interaction specificity for a broad range of synthetic biology applications. PMID:27151862

  12. Effect of a Disease-Specific Planning Intervention on Surrogate Understanding of Patient Goals for Future Medical Treatment

    Science.gov (United States)

    Kirchhoff, Karin T.; Hammes, Bernard J.; Kehl, Karen A.; Briggs, Linda A.; Brown, Roger L.

    2010-01-01

    Context Patients with life-limiting illnesses, and their families, struggle with complex treatment decisions as these patients approach the last few years of life. Surrogates often do not clearly understand the patient's goals for future medical treatments. Objectives To determine if a disease-specific planning process can improve surrogate understanding of such patient goals for future, medical treatments. Design, Setting, and Participants A multisite randomized controlled trial conducted between January 1, 2004 and July 31, 2007 in 6 outpatient clinics of large community or university health systems in 3 Wisconsin cities. Subjects were patients with either chronic congestive heart failure or chronic renal disease and their surrogate decision makers. Participants had to be competent, English-speaking adults at least 18 years of age. Intervention Trained health professionals conducted a structured, patient-centered interview intended to promote informed decision making and to result in the completion of a document clarifying the goals of the patient with regard to four disease-specific health outcome situations and to the degree of decision-making latitude granted to the surrogate. Measurements Surrogate understanding of patient goals for care with regard to four expected, disease-specific outcomes situations and of the degree of surrogate latitude in decision making. Results Three hundred thirteen patient-surrogate pairs completed the study. As measured by Kappa (κ) scores and in all four situations and in the degree of latitude, intervention group surrogates demonstrated a significantly higher degree of understanding of patient goals than control group surrogates. Intervention group κ scores ranged from 0.61 to 0.78, while control group κ scores ranged from 0.07 to 0.28. Conclusion Surrogates in the intervention group had a significantly better understanding of patient goals and preferences than surrogates in the control group. This finding is the first step

  13. Applying the Art of Systems and Organizational Architecting in Order to Implement Operational Design into Marine Corps Planning Doctrine

    Science.gov (United States)

    2011-09-01

    Making Process OEF Operation Enduring Freedom OIF Operational Iraqi Freedom OPORDS Operational Orders RSE Rapid Systems Engineering TTPs Tactics...and Complexity, A Platform for Designing Business Architecture and elements of Rapid Systems Engineering ( RSE ) as applied by Professor Gary Langford...planning process combines elements of business design (Gharajedaghi, 2006) and RSE (Langford, 2006) to create a more robust design-planning continuum

  14. SP-Designer: a user-friendly program for designing species-specific primer pairs from DNA sequence alignments.

    Science.gov (United States)

    Villard, Pierre; Malausa, Thibaut

    2013-07-01

    SP-Designer is an open-source program providing a user-friendly tool for the design of specific PCR primer pairs from a DNA sequence alignment containing sequences from various taxa. SP-Designer selects PCR primer pairs for the amplification of DNA from a target species on the basis of several criteria: (i) primer specificity, as assessed by interspecific sequence polymorphism in the annealing regions, (ii) the biochemical characteristics of the primers and (iii) the intended PCR conditions. SP-Designer generates tables, detailing the primer pair and PCR characteristics, and a FASTA file locating the primer sequences in the original sequence alignment. SP-Designer is Windows-compatible and freely available from http://www2.sophia.inra.fr/urih/sophia_mart/sp_designer/info_sp_designer.php. © 2013 John Wiley & Sons Ltd.

  15. Mission Design Evaluation Using Automated Planning for High Resolution Imaging of Dynamic Surface Processes from the ISS

    Science.gov (United States)

    Knight, Russell; Donnellan, Andrea; Green, Joseph J.

    2013-01-01

    A challenge for any proposed mission is to demonstrate convincingly that the proposed systems will in fact deliver the science promised. Funding agencies and mission design personnel are becoming ever more skeptical of the abstractions that form the basis of the current state of the practice with respect to approximating science return. To address this, we have been using automated planning and scheduling technology to provide actual coverage campaigns that provide better predictive performance with respect to science return for a given mission design and set of mission objectives given implementation uncertainties. Specifically, we have applied an adaptation of ASPEN and SPICE to the Eagle-Eye domain that demonstrates the performance of the mission design with respect to coverage of science imaging targets that address climate change and disaster response. Eagle-Eye is an Earth-imaging telescope that has been proposed to fly aboard the International Space Station (ISS).

  16. Mission Design Evaluation Using Automated Planning for High Resolution Imaging of Dynamic Surface Processes from the ISS

    Science.gov (United States)

    Knight, Russell; Donnellan, Andrea; Green, Joseph J.

    2013-01-01

    A challenge for any proposed mission is to demonstrate convincingly that the proposed systems will in fact deliver the science promised. Funding agencies and mission design personnel are becoming ever more skeptical of the abstractions that form the basis of the current state of the practice with respect to approximating science return. To address this, we have been using automated planning and scheduling technology to provide actual coverage campaigns that provide better predictive performance with respect to science return for a given mission design and set of mission objectives given implementation uncertainties. Specifically, we have applied an adaptation of ASPEN and SPICE to the Eagle-Eye domain that demonstrates the performance of the mission design with respect to coverage of science imaging targets that address climate change and disaster response. Eagle-Eye is an Earth-imaging telescope that has been proposed to fly aboard the International Space Station (ISS).

  17. Planning for School Emergencies.

    Science.gov (United States)

    Della-Giustina, Daniel E.

    This document is designed to provide civil leaders and school administrators with a resource that will enable them to develop comprehensive contingency plans for specific emergency situations. A discussion of disaster and emergency management planning includes an outline of the objectives of emergency planning that were established for this guide.…

  18. Computer-Designed Splints for Surgical Transfer of 3D Orthognathic Planning.

    Science.gov (United States)

    Zinser, Max; Zoeller, Joachim

    2015-10-01

    Advances in computers and imaging have permitted the adoption of three-dimensional (3D) planning protocols in orthognathic surgery, which may allow a paradigm shift when the computer-assisted planning can be transferred properly. The purpose of this investigation was to introduce an innovative clinical protocol using computer-aided designed and computer-aided manufactured (CAD/CAM) surgical splints for surgical transfer of 3D orthognathic planning compared with the classic technique using arbitrary occlusal splints. The clinical protocols consisted of computed tomography (CT) or cone-beam CT (CBCT) maxillofacial imaging, bone segmentation, 3D diagnosis, computer-assisted surgical treatment planning, and CAD/CAM surgical splints (group A) and manufacture of arbitrary occlusal splints (group B) for intraoperative surgical planning transfer. The observed patients underwent bimaxillary osteotomies and, if necessary, an additional genioplasty. Both techniques were evaluated by applying 13 hard tissue parameters to compare the 3D orthognathic planning (T0) with the postoperative result (T1) using 3D cephalometry. The CAD/CAM splints showed significant better precision for the maxilla (ΔT orthognathic planning, which is more precise compared with the conventional arbitrary occlusal splints.

  19. Planning for a program design for energy environmental analysis. Final report, draft

    Energy Technology Data Exchange (ETDEWEB)

    Denton, J; Saaty, T; Blair, P; Ma, F; Buneman, P

    1976-04-01

    The objective of the work reported here is to assist BER/ERDA in program planning with respect to a regional assessment study program for energy environmental analysis. The focus of the work was to examine the use of operational gaming fof regional assessment studies. Specific concerns were gaming applications (1) in regional assessment or management and direction of regional assessments; (2) for achieving a higher level of public understanding of environmental, health, and safety problems of energy; (3) with respect to the supply of adequately trained manpower for energy; (4) with respect to computational requirements; and (5) with respect to current state-of-the-art in computer simulation. In order to investigate these concerns and examine the feasibility of using operational gaming in a regional assessment study program, a Regional Energy Environment Game (REEG) was designed and implemented on an IBM 370/168 digital computer employing APL (A Programming Language). The applicability of interactive operational gaming has been demonstrated by the REEG as applied to a region consisting of Delaware, Maryland, New Jersey, Pennsylvania, and the District of Columbia.

  20. Therapeutic modulation of endogenous gene function by agents with designed DNA-sequence specificities

    NARCIS (Netherlands)

    Uil, T.G.; Haisma, H.J.; Rots, Marianne

    2003-01-01

    Designer molecules that can specifically target pre-determined DNA sequences provide a means to modulate endogenous gene function. Different classes of sequence-specific DNA-binding agents have been developed, including triplex-forming molecules, synthetic polyamides and designer zinc finger protein

  1. Dynamic supply chain network design with capacity planning and multi-period pricing

    DEFF Research Database (Denmark)

    Fattahi, Mohammad; Mahootchi, Masoud; Govindan, Kannan

    2015-01-01

    This paper addresses a new problem in designing and planning a multi-echelon and multi-product supply chain network over a multi-period horizon in which customer zones have price-sensitive demands. Based on price-demand relationships, a generic method is presented to obtain price levels...

  2. 75 FR 26685 - Approval and Promulgation of Implementation Plans and Designation of Areas for Air Quality...

    Science.gov (United States)

    2010-05-12

    ... subpart 1, based upon their 8-hour ambient air quality design values. Northern Kentucky (as part of the bi... Air Quality Planning Purposes; Kentucky; Redesignation of the Kentucky Portion of the Cincinnati... Energy and Environment Cabinet, Division for Air Quality (DAQ), submitted a request to redesignate...

  3. Design and implementation of a financial planning and tracking system for the Nova Project

    Energy Technology Data Exchange (ETDEWEB)

    Holcomb, F.

    1982-01-01

    The Nova project is a 185 million dollar DOE funded project to build an experimental facility to demonstrate the thermonuclear ignition of laser fusion targets. This paper describes the design and implementation considerations for the project's computerized performance measurement financial planning and tracking system and critiques its actual operation.

  4. PC-based Multiple Information System Interface (PC/MISI) detailed design and implementation plan

    Science.gov (United States)

    Dominick, Wayne D. (Editor); Hall, Philip P.

    1985-01-01

    The design plan for the personal computer multiple information system interface (PC/MISI) project is discussed. The document is intended to be used as a blueprint for the implementation of the system. Each component is described in the detail necessary to allow programmers to implement the system. A description of the system data flow and system file structures is given.

  5. Optimal Assignment Methods in Three-Form Planned Missing Data Designs for Longitudinal Panel Studies

    Science.gov (United States)

    Jorgensen, Terrence D.; Rhemtulla, Mijke; Schoemann, Alexander; McPherson, Brent; Wu, Wei; Little, Todd D.

    2014-01-01

    Planned missing designs are becoming increasingly popular, but because there is no consensus on how to implement them in longitudinal research, we simulated longitudinal data to distinguish between strategies of assigning items to forms and of assigning forms to participants across measurement occasions. Using relative efficiency as the criterion,…

  6. Urban Planning for a Renewable Energy Future: Methodological Challenges and Opportunities from a Design Perspective

    Directory of Open Access Journals (Sweden)

    Han Vandevyvere

    2012-06-01

    Full Text Available Urban planning for a renewable energy future requires the collaboration of different disciplines both in research and practice. In the present article, the planning of a renewable energy future is approached from a designer’s perspective. A framework for analysis of the planning questions at hand is first proposed. The framework considers two levels of inquiry: the technical environmental aspect, and its wider embedding in sustainable development. Furthermore, life cycle analysis and exergy studies are discussed for their application potential in design. An altered trias energetica as proposed in earlier publications appears to remain a robust concept for low exergy, renewable energy based urban design. When considering sustainable development, environmental assessments shall be completed by an inquiry of the socio-cultural, economical, juridical, aesthetical and ethical aspects characterizing the planning or decision process. The article then presents a number of practical design principles that can help envisioning a built environment that can be sustained on the basis of renewable energy sources. In accordance with the altered trias energetica concept, elements of passive urban energy design, exergetic optimization of energy provision systems and the sourcing of renewable energy are identified, and their respective potentials assessed.

  7. The Green Book: Planning and design guidelines for adapting South African settlement to climate change

    CSIR Research Space (South Africa)

    Van Niekerk, Cornelia W

    2016-09-01

    Full Text Available The purpose of this IDRC funded project is to the develop a set of guidelines by March 2019 – called the Green Book – to adapt existing and future South African settlements to climatic changes. The Green Book is to be used as a planning and design...

  8. 78 FR 16792 - Designation of Areas for Air Quality Planning Purposes; State of California; Imperial Valley...

    Science.gov (United States)

    2013-03-19

    ... (see, e.g., the PM 10 area designations in 40 CFR 81.305 for Coso Junction planning area, Owens Valley... before a rule may take effect, the agency promulgating the rule must submit a rule report, which includes... States. EPA will submit a report containing this action and other required information to the U.S. Senate...

  9. K Basin sludge packaging design criteria (PDC) and safety analysis report for packaging (SARP) approval plan

    Energy Technology Data Exchange (ETDEWEB)

    Brisbin, S.A.

    1996-03-06

    This document delineates the plan for preparation, review, and approval of the Packaging Design Crieteria for the K Basin Sludge Transportation System and the Associated on-site Safety Analysis Report for Packaging. The transportation system addressed in the subject documents will be used to transport sludge from the K Basins using bulk packaging.

  10. The implementation of the integrated design process in the hole-plan system

    Science.gov (United States)

    Ruy, Won-Sun; Ko, Dae-Eun; Yang, Young-Soon

    2012-12-01

    All current shipyards are using the customized CAD/CAM programs in order to improve the design quality and increase the design efficiency. Even though the data structures for ship design and construction are almost completed, the implementation related to the ship design processes are still in progress so that it has been the main causes of the bottleneck and delay during the middle of design process. In this study, we thought that the hole-plan system would be a good example which is remained to be improved. The people of outfitting division who don't have direct authority to edit the structural panels, should request the hull design division to install the holes for the outfitting equipment. For acceptance, they should calculate the hole position, determine the hole type, and find the intersected contour of panel. After consideration of the hull people, the requested holes are manually installed on the hull structure. As the above, many processes are needed such as communication and discussion between the divisions, drawings for hole-plan, and the consideration for the structural or production compatibility. However this iterative process takes a lot of working time and requires mental pressure to the related people and cross-division conflict. This paper will handle the hole-plan system in detail to automate the series of process and minimize the human efforts and time-consumption.

  11. Strategies in architectural design and urban planning in the context of energy efficiency in buildings

    Directory of Open Access Journals (Sweden)

    Vuksanović Dušan

    2007-01-01

    Full Text Available Some of the design concepts in architecture and urban planning, created on demands of energy efficiency, that apply in early stages of design process a schematic design, i.e. in the phase of creating the basis of architectural or planning solution, are analyzed in this paper. These design strategies have a role to be comprehensive enough to provide application of their key potentials, but at the same time they need to remain simple enough and not burden a designer with inadequate number of information. Design models for passive heating, passive cooling and natural lighting that refer to the buildings mainly have been considered, together with the principles for the settlements or building groups. Guiding a design concept towards the one of described design principles e.g. their application within the diurnal and seasonal cycles, depends on local climatic conditions and type of building (residential, commercial or educational. The presentation of a model is followed by the explanation of the phenomena of impacts/influences (climate program and answers (the concept, passive components related to a certain strategy, and by the illustration of a strategy on a realized object (case study. Issues of design strategies on energy efficiency are considered through different levels, e.g. through spatial organization, form and added components of buildings, as well as structure and characteristics of elements of external structures - facades and roofs.

  12. Planning and Designing Facilities. Facility Design and Development--Part 1

    Science.gov (United States)

    Hypes, Michael G.

    2006-01-01

    Before one begins the planning process for a new facility, it is important to determine if there is a need for a new facility. The demand for a new facility can be drawn from increases in the number of users, the type of users, and the type of events to be conducted in the facility. A feasibility study should be conducted to analyze the legal…

  13. Pediatric investigation plans for specific immunotherapy: Questionable contributions to childhood health.

    Science.gov (United States)

    Rose, Klaus; Kopp, Matthias Volkmar

    2015-12-01

    Allergen-specific immunotherapy (SIT) is the only disease-modifying treatment for children, adolescents, and adults with allergic diseases. The EU has a combined system of national and EU-wide marketing authorization for all medicines. Germany introduced a new therapy allergen ordinance in 2008. Allergen products manufacturers had to apply for marketing authorization application for the major allergen groups (grass group, birch group, mites group, bee/wasp venom). Due to the EU pediatric regulation, in force since 2007, manufacturers had also to submit a pediatric investigation plan (PIP) for each allergen product. We investigated the allergic rhinoconjunctivitis (ARC) standard PIP, developed jointly by the European Medicines Agency (EMA) and the German Paul Ehrlich Institut (PEI). We analyzed the 118 EMA PIP decisions, looked for SIT trials in children in www.clinicaltrials.gov, and further analyzed EMA/EU justifications. The PIPs request a 1-year dose-finding study in adults, a 5-year placebo-controlled (PC) efficacy & safety (E&S) study in adults, and a 5-year PC E&S study in children. Fifty-eight PIP development programs will have to be performed until 2031. But children benefit even more from SIT for ARC than adults. There is no convincing medical/scientific justification for PC E&S studies in children in the relevant EMA documents. The PIP requirement to withhold effective treatment to thousands of children in the placebo group over a 5-year period raises profound concerns. The EMA justifications are formalistic and lack scientific foundation. A critical academic review of the ARC PIPs and the entire PIP system is urgently needed.

  14. Preliminary design of the Carrisa Plains solar central receiver power plant. Volume II. Plant specifications

    Energy Technology Data Exchange (ETDEWEB)

    Price, R. E.

    1983-12-31

    The specifications and design criteria for all plant systems and subsystems used in developing the preliminary design of Carrisa Plains 30-MWe Solar Plant are contained in this volume. The specifications have been organized according to plant systems and levels. The levels are arranged in tiers. Starting at the top tier and proceeding down, the specification levels are the plant, system, subsystem, components, and fabrication. A tab number, listed in the index, has been assigned each document to facilitate document location.

  15. Optimal Design of Multiple Stresses Accelerated Life Test Plan Based on Transforming the Multiple Stresses to Single Stress

    Institute of Scientific and Technical Information of China (English)

    GAO Liang; CHEN Wenhua; QIAN Ping; PAN Jun; HE Qingchuan

    2014-01-01

    For planning optimum multiple stresses accelerated life test plans, a commonly followed guiding principle is that all parameters of the life-stress relationship should be estimated, and the number of the stress level combinations must be no less than the number of parameters of the life-stress relationship. However, the general objective of an accelerated life test(ALT) is to assess thep-th quantile of the product life distribution under normal stress. For this objective,estimating all model parameters is not necessary, and this will increase the cost of test. Based on the theoretical conclusion that the stress level combinations of the optimum multiple stresses ALT plan locate on a straight line through the origin of coordinate, it is proposed that a design idea of planning the optimum multiple stresses ALT plan through transforming the problem of designing an optimum multiple stresses ALT plan to designing an optimum single stress ALT plan. Moreover, a method of planning the optimum multiple stresses ALT plan which can avoid estimating all model parameters is established. An example shows that, the proposed plan which only has two stress level combinations could achieve an accuracy no less than the traditional plan, and save the test time and cost on one stress level combination at least; when the actual product life is less than the design value, even the deviation of the model initial parameters value is up to 20%, the variance of the estimation of thep-th quantile of the proposed plan is still smaller than the traditional plans approximately 25%. A design method is provided for planning the optimum multiple stresses ALT which uses the statistical optimum degenerate test plan as the optimum multiple stresses accelerated life test plan.

  16. The importance of specific human capital, planning and familiarity in Dutch small firm ownership transfers : a seller’s perspective

    NARCIS (Netherlands)

    Teeffelen, Lex van; Uhlaner, Lorraine; Driessen, Martijn

    2011-01-01

    This study focuses on the transfer process and the importance of human capital and succession planning as firm resource from the seller’s perspective. It further differentiates amongst two types of human capital - specific and generic - to predict the transfer duration, obtained price and satisf

  17. Theory of Planned Behavior: Sensitivity and Specificity in Predicting Graduation and Drop-Out among College and University Students?

    Science.gov (United States)

    Fichten, Catherine S.; Amsel, Rhonda; Jorgensen, Mary; Nguyen, Mai Nhu; Budd, Jillian; King, Laura; Jorgensen, Shirley; Asuncion, Jennison

    2016-01-01

    We examined sensitivity and specificity when using the three theory of planned behavior (TPB) scales (Perceived Behavioral Control, Subjective Norms, Attitude) to predict graduation and drop-out in a longitudinal study of 252 college and university students with disabilities and in a separate cross-sectional study of a random sample of 1380…

  18. The national strategic plan for federal aquaculture research, specific goal #4: Improve production efficiency and well-being

    Science.gov (United States)

    The 2014-2019 National Strategic Plan for Federal Aquaculture Research identifies a series of specific goals that identify research priorities for Federal agency and interagency research programs. Collectively, these priorities define research activities with the broad outcome of supporting aquacul...

  19. OTS/CafeOBJ2JML: An attempt to combine Design By Contract with Behavioral Specifications

    CERN Document Server

    Triantafyllou, Nikolaos; Frangos, Panayiotis

    2012-01-01

    Design by Constract (DBC) has influenced the development of formal specification languages that allow the mix of specification and implementation code, like Eiffel, the Java Modeling Language (JML) and Spec#. Meanwhile algebraic specification languages have been developing independently and offer full support for specification and verification of design for large and complex systems in a mathematical rigorous way. However there is no guarantee that the final implementation will comply to the specification. In this paper we proposed the use of the latter for the specification and verification of the systems design and then by presenting a translation between the two, the use of the former to ensure that the implementation respects the specification and thus enjoy the verified properties.

  20. Improvement of tool support of the spatial approach to regional planning: problems, specifics, trends

    Directory of Open Access Journals (Sweden)

    Nataliya Gennadievna Yushkova

    2015-01-01

    Full Text Available The emerging imperatives of innovation economic development in Russia determine the content of conceptual and institutional constraints to the development of regional economic systems (RES. They consider the regional planning system as a leading priority in its inseparable unity with modern public administration tasks. However, the practice of development of long-term plans in the RF subjects proves that the innovation challenges of economic policy are not reflected properly in them or they are significantly distorted. The following reasons reduce the effectiveness of modernization processes in the RF subjects and hamper the appropriate reaction of RES on their impact: the lack of coordination between socio-economic and spatial regional plans, the imbalance of interaction between state authorities engaged in long-term planning, the lack of real prerequisites for the implementation of innovation initiatives in the regions. Systematization and analysis of long-term plans make it possible to substantiate the consistency of the spatial approach to regional planning expressed in the dominance of the transformational function that synchronizes the configuration and parameters of RES, and to establish ways to integrate spatial components in the system of regional planning through optimization of its tool support. The change in the content of the instrumentation support is based on the synthesis of the predominant basic characteristics of the existing tools used in isolated subsystems of regional planning of socio-economic and territorial development. The study has established a system of tool support for regional planning that adapts to the changes in both internal and external factors in the development of RES. Three main groups of tools: organizing, regulating, and coordinating are defined by their typing in accordance with the groups of management functions. The article proposes the modeling of combinations of tools that are subordinated to the

  1. Designing for Culturally Contextualized Learning Activity Planning: Matching Learning Theories and Practice

    Science.gov (United States)

    de Carvalho, Aparecido Fabiano Pinatti; Anacleto, Junia Coutinho; de Almeida Neris, Vania Paula

    Helping teachers in their activities has been an issue more and more explored in Computer Science. However, in order to support teachers effectively, it is necessary to understand their needs and to design tools that they can easily manage. One of those needs is undoubtedly to put in practice pedagogical principles. This paper presents the design of PACO-T, a tool for helping teachers in planning learning activities (LAs) supported by common sense knowledge, based on PACO, a seven-step textual framework for planning pedagogically suitable LAs. The design was based on the results of a case study carried out to investigate how teachers can plan LAs following PACO steps, using common sense knowledge from a common sense knowledge base collaboratively built through the web. Moreover, the interface design was ruled by a Web Design Pattern Language, attempting to improve the usability of the tool. PACO-T aims to help teachers to put in practice the recommendation for contextualizing LAs to the target group, found in several learning theories.

  2. General systems theory, cultural change, and a human science foundation for planning and design

    Energy Technology Data Exchange (ETDEWEB)

    Motloch, J.L.; Woodfin, T.

    1993-12-31

    This paper integrates the knowledge-base concerning systems, their behavior and structure, and the management of complex systems - to provide insight to physical planning and design in equilibrium and rapidly-changing conditions. It contributes to the redefinition of the professions of physical planning and design; and the establishment of their human science foundations. This paper begins with a description of general systems theory, and the types of organizational structures that emerge in systems that are either in a state of equilibrium, controlled change, or chaos. It addresses the changes in system dynamics that occur as a culture moves from a condition of equilibrium or slow evolutionary change, to one of profound, rapid change. Conceptual approaches to decision-making to address these changing conditions are explored, with a focus on strategies to manage change and retard its rate, or conversely to maximize rate of change with reduced ability to manage that change. The paper presents the recent history of South Africa, Value Systems Theory and the differential manner in which people image the world - in an effort to establish intergroup harmony. It introduces problems that are emerging due to different value systems and need satisfaction; and on-going efforts to facilitate rapid paradigmatic change through equilibrium processes. The paper addresses recent efforts at the national level, roadblocks to change, and {open_quotes}change triggers{close_quotes} that can facilitate that change. It addresses case-study research to identify urbanization {open_quotes}delivery models{close_quotes} that can facilitate change at the local community-planning level. This paper develops the scientific basis within which to address urban planning and design as community facilitation, and as the management of ecological and human health. It establishes the need for a human science foundation for physical planning and design. 116 refs.

  3. Predicting changes in blood flow in patient-specific operative plans for treating aortoiliac occlusive disease.

    Science.gov (United States)

    Wilson, Nathan M; Arko, Frank R; Taylor, Charles A

    2005-07-01

    Traditionally, a surgeon will select a procedure for a particular patient on the basis of past experience with patients with a similar state of disease. The experience gained from this patient will be selectively used when treating the next patient with similar symptoms. This article describes a surgical planning system that was developed to enable a vascular surgeon to create and test alternative operative plans prior to surgery for a given patient. One-dimensional and three-dimensional hemodynamic (i.e., blood flow) simulations were performed for rest and exercise for operative plans for two aorto-femoral bypass patients and compared with actual postoperative data. The information obtained from one-dimensional (volume flow distribution and pressure losses) and three-dimensional (flow, pressure, and wall shear stress) hemodynamic simulations may be clinically relevant to vascular surgeons planning interventions.

  4. Design and construction coordination problems and planning for design-build project new users

    National Research Council Canada - National Science Library

    Shen, Fang-Ying; Chang, Andrew S; Ibbs, William

    2010-01-01

    ... to be encountered in execution by new users. This paper investigates coordination problems arising from design and construction concurrence and solutions by studying five ongoing DB projects and interviewing nine major contract parties...

  5. Patient-specific positioning guides do not consistently achieve the planned implant position in UKA.

    Science.gov (United States)

    van Leeuwen, Justin A M J; Röhrl, Stephan M

    2017-03-01

    To investigate whether the intended preoperative planning corresponded with the postoperative component position after medial UKA using patient-specific positioning guides (PSPGs). Twenty-five consecutive UKAs performed with the PSPG technique (Signature™) were included. Two independent observers performed postoperative CT measurements. The preoperative angles for the femoral component were defined in the frontal plane as 0°. In the first eight cases, a femoral component with single peg was inserted, and the flexion of the femoral component was set to 5°. In the last 17 cases, a twin-peg component was used and flexion set to 10°. In the axial plane, the femoral component was on average set at 2.5° internal rotation. The preoperative tibial component angles in the frontal and axial plane were defined as 0° and in the sagittal plane as 4° in flexion. The postoperative femoral component angles were on average 0.8° of valgus (SD 3.2, range 12.2° valgus to 5.1° varus, n.s., CI -2.1 to 0.6), 5.0° of flexion (SD 3.9, range 10.2° flexion to 6.0° extension, p = 0.001, CI -5.3 to -1.5) and 4.0° of internal rotation (SD 1.7, range 1.4° to 6.9° int.rot., p < 0.001, CI -4.7 to -3.4). The tibial component angles were on average 3.0° of varus (SD 1.9, range 1.3° valgus to 6.8° varus, p < 0.001, CI 2.2 to 3.8), 3.2° of flexion (SD 2.4°, 6.7° flex to 1.8° ext, n.s., CI -0.2 to 1.7) and 2.7° of internal rotation (SD 7.0, range 16.6° int.rot. to 10.7° ext.rot., n.s., CI -5.6 to 0.2). This study showed no agreement between preoperative planning and postoperative component alignment (p < 0.05) for the femoral component angle in sagittal and axial plane and for the tibial component angle in the coronal plane. Although the results did not show significant difference for the tibial component angle in the axial plane, a considerable range of the component angles was found varying from 17° internal to 11° external rotation. This study suggests that the

  6. Design of the real time systems using temporal logic specifications: a case study

    Directory of Open Access Journals (Sweden)

    A. Ursu

    1996-07-01

    Full Text Available An implementation method for real time systems is proposed in this article. The implementation starts with the design of the functional specifications of the systems behaviour. The functional specifications are introduced as a set of rules describing the partial time ordering of the actions performed by the system. These rules are then written in terms of temporal logic formulae. The temporal logic formulae are checked using Z.Manna-P.Wolper satisfiability analysis procedure [1]. It is known that this procedure generates a state-graph which can be regarded as a state- based automaton of the system. The sate-based automaton is used then to generate the dual (inverted automaton of the system. The dual automaton is called action-based automaton and can be created using the procedure proposed by authors in [4,5]. Using the action-based automaton of the system the design method introduced in [5,6] is applied to implement the system driver in a systematic manner which can be computerised. The method proposed in this paper is an efficient complementation and generalisation of the results [4,5,6] mentioned above. The method is used for a case study. An elevator control system is designed using the proposed method. The design is carried out in a systematic manner which includes: a design of functional specifications, b design of temporal logic specifications, c satisfiability analysis of temporal logic specifications, d design of the state-based automaton of the specifications, e design of the action-based automaton of the system, f design of the transition activation conditions, g design of the action activation conditions, h design of the functional model of the elevator control system, i implementation of the elevator's actions, j design of the elevator control system driver.

  7. Adapt Design: A Methodology for Enabling Modular Design for Mission Specific SUAS

    Science.gov (United States)

    2016-08-24

    the application of this approach are presented via the design of several SUAS. The capability of the design paradigm is assessed through a...is succinctly explained via an analogy to Lego® depicted in Figure 2. Lego® bricks contain a number of modular parts that can be constructed into...stakeholders drives a need for providing users with a small set of inputs that can fully capture the mission, without requiring detailed knowledge of

  8. An operational information systems architecture for assessing sustainable transportation planning: principles and design.

    Science.gov (United States)

    Borzacchiello, Maria Teresa; Torrieri, Vincenzo; Nijkamp, Peter

    2009-11-01

    This paper offers the description of an integrated information system framework for the assessment of transportation planning and management. After an introductory exposition, in the first part of the paper, a broad overview of international experiences regarding information systems on transportation is given, focusing in particular on the relationship between transportation system's performance monitoring and the decision-making process, and on the importance of this connection in the evaluation and planning process, in Italian and European cases. Next, the methodological design of an information system to support efficient and sustainable transportation planning and management aiming to integrate inputs from several different data sources is presented. The resulting framework deploys modular and integrated databases which include data stemming from different national or regional data banks and which integrate information belonging to different transportation fields. For this reason, it allows public administrations to account for many strategic elements that influence their decisions regarding transportation, both from a systemic and infrastructural point of view.

  9. Design and implementation of motion planning of inspection and maintenance robot for ITER-like vessel

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Hesheng; Lai, Yinping [Department of Automation, Shanghai Jiao Tong University, Shanghai 200240 (China); Key Laboratory of System Control and Information Processing, Ministry of Education of China (China); Chen, Weidong, E-mail: wdchen@sjtu.edu.cn [Department of Automation, Shanghai Jiao Tong University, Shanghai 200240 (China); Key Laboratory of System Control and Information Processing, Ministry of Education of China (China); Cao, Qixin [Institute of Robotics, Shanghai Jiao Tong University, Shanghai 200240 (China)

    2015-12-15

    Robot motion planning is a fundamental problem to ensure the robot executing the task without clashes, fast and accurately in a special environment. In this paper, a motion planning of a 12 DOFs remote handling robot used for inspecting the working state of the ITER-like vessel and maintaining key device components is proposed and implemented. Firstly, the forward and inverse kinematics are given by analytic method. The work space and posture space of this manipulator are both considered. Then the motion planning is divided into three stages: coming out of the cassette mover, moving along the in-vessel center line, and inspecting the D-shape section. Lastly, the result of experiments verified the performance of the motion design method. In addition, the task of unscrewing/screwing the screw demonstrated the feasibility of system in function.

  10. RELOCATION OF HOME APPLIANCES FACTORY BY USING SYSTEMATICAL LAYOUT PLANNING (SLP COMBINED WITH FLOW ANALYSIS AND ASSEMBLY PROCESS DESIGN

    Directory of Open Access Journals (Sweden)

    Yosef Adji Baskoro

    2011-12-01

    Full Text Available Every manufacturing company must have experiencing building a layout. Fred.E Meyers has stated that only death and taxes are certain, there exist a third certainty-a plant layout will change, thus many methods to generate layout are established and each has its own purposes and benefits. This research focused on the design of manufacturing facilities supported by in-depth analysis of Assembly process design with a high stresses on the Systematical Layout Planning ( SLP and Flow Analysis method to facilitate an outcome of layout accordingly to the system needs. This is a real case study conducts with an objective of generating a recommendation layout for Home Appliances Company specifically for television plant

  11. RELOCATION OF HOME APPLIANCES FACTORY BY USING SYSTEMATICAL LAYOUT PLANNING (SLP COMBINED WITH FLOW ANALYSIS AND ASSEMBLY PROCESS DESIGN

    Directory of Open Access Journals (Sweden)

    Yosef Adji Baskoro

    2011-12-01

    Full Text Available Every manufacturing company must have experiencing building a layout. Fred.E Meyers has stated that only death and taxes are certain, there exist a third certainty-a plant layout will change, thus many methods to generate layout are established and each has its own purposes and benefits. This research focused on the design of manufacturing facilities supported by in-depth analysis of Assembly process design with a high stresses on the Systematical Layout Planning ( SLP and Flow Analysis method to facilitate an outcome of layout accordingly to the system needs. This is a real case study conducts with an objective of generating a recommendation layout for Home Appliances Company specifically for television plant.

  12. SIMULATION BASED PLANNING FOR DESIGN OF WASHING MACHINE USING H/W & S/W CO DESIGN

    Directory of Open Access Journals (Sweden)

    Rajesh Kumar Garg

    2010-11-01

    Full Text Available A simulator is designed and developed or helping embedded system development team to plan their time schedule, work flow etc. and distribute human resources and their efforts over various phasesof washing machine development. The simulator helps in identifying development phases of washing machine for successful operations of overall system. The development process of washing machine has beendone in a cost effective way by planning and managing and simulating the system. The simulator gives the results in form of critical and near-critical phases while considering the rest of phases as concurrent development activities. The simulator has been a handytool for engineers in developing the system in an optimal manner. Hardware/Software Codesign approach in which both hardware and software designers’ work together to develop a system is used inthis work.

  13. The Planning and Digital Design for Welding Production Line of the Car Rear Floor

    Directory of Open Access Journals (Sweden)

    Zhang Chun-Yan

    2013-06-01

    Full Text Available The last two sub-assembly welding production line of the car rear floor is designed in this paper. Firstly, the welding production line of the car rear floor is complete planned and designed from global aspect by analysis the structure of body-in-white and the car rear floor; Secondly, each working position fixture are designed and the location of all fixture are arranged according to location and spot welding requirements with the CATIA software. Finally, the conveying appliance of welding production line for the car rear floor are detailed planed, according to the production program, the economic requirements to complete a three-dimensional design of delivery devices, ergonomic simulation and dynamic interference checking in the process of material transportation are realized in virtual simulation platform DELMIA software, to ensure the production line design is reasonable and feasible from theory.

  14. Formulation of a parametric systems design framework for disaster response planning

    Science.gov (United States)

    Mma, Stephanie Weiya

    The occurrence of devastating natural disasters in the past several years have prompted communities, responding organizations, and governments to seek ways to improve disaster preparedness capabilities locally, regionally, nationally, and internationally. A holistic approach to design used in the aerospace and industrial engineering fields enables efficient allocation of resources through applied parametric changes within a particular design to improve performance metrics to selected standards. In this research, this methodology is applied to disaster preparedness, using a community's time to restoration after a disaster as the response metric. A review of the responses from Hurricane Katrina and the 2010 Haiti earthquake, among other prominent disasters, provides observations leading to some current capability benchmarking. A need for holistic assessment and planning exists for communities but the current response planning infrastructure lacks a standardized framework and standardized assessment metrics. Within the humanitarian logistics community, several different metrics exist, enabling quantification and measurement of a particular area's vulnerability. These metrics, combined with design and planning methodologies from related fields, such as engineering product design, military response planning, and business process redesign, provide insight and a framework from which to begin developing a methodology to enable holistic disaster response planning. The developed methodology was applied to the communities of Shelby County, TN and pre-Hurricane-Katrina Orleans Parish, LA. Available literature and reliable media sources provide information about the different values of system parameters within the decomposition of the community aspects and also about relationships among the parameters. The community was modeled as a system dynamics model and was tested in the implementation of two, five, and ten year improvement plans for Preparedness, Response, and Development

  15. Potentials for site-specific design of MW sized wind turbines

    DEFF Research Database (Denmark)

    Thomsen, K.; Fuglsang, P.; Schepers, G.

    2001-01-01

    The potential for site specific design of MW sized wind turbines is quantified by comparing design loads for wind turbines installed at a range of different sites. The sites comprise on-shore normal flat terrain stand-alone conditions and wind farm conditions together with offshore and mountainous...... complex terrain wind farms. The design loads are established for a 1 MW active stall regulated wind turbine with the aeroelastic code HAWC. The load analysis is limited to fatigue loads. We do not consider ultimate loads in this paper. The results illustrate the differences in design wind conditions...... for different sites and the related differences in design loads for the 1 MW wind turbine. Based on the difference in the design loads, the potentials for site specific design of the wind turbine main components are identified. The results show that the variation in aerodynamically driven loads and energy...

  16. 18th edition of the Forum on specification and Design Languages Conference

    CERN Document Server

    Wille, Robert

    2016-01-01

    This book brings together a selection of the best papers from the eighteenth edition of the Forum on specification and Design Languages Conference (FDL), which took place on September 14-16, 2015, in Barcelona, Spain. FDL is a well-established international forum devoted to dissemination of research results, practical experiences and new ideas in the application of specification, design and verification languages to the design, modeling and verification of integrated circuits, complex hardware/software embedded systems, and mixed-technology systems. Covers Assertion Based Design, Verification & Debug; Includes language-based modeling and design techniques for embedded systems; Covers design, modeling and verification of mixed physical domain and mixed signal systems that include significant analog parts in electrical and non-electrical domains; Includes formal and semi-formal system level design methods for complex embedded systems based on the Unified Modelling Language (UML) and Model Driven Engineering...

  17. 17th edition of the Forum on specification and Design Languages Conference

    CERN Document Server

    Pasaje, Julio

    2016-01-01

    This book brings together a selection of the best papers from the seventeenth edition of the Forum on specification and Design Languages Conference (FDL), which took place on October 14-16, 2014, in Munich, Germany.  FDL is a well-established international forum devoted to dissemination of research results, practical experiences and new ideas in the application of specification, design and verification languages to the design, modeling and verification of integrated circuits, complex hardware/software embedded systems, and mixed-technology systems.   •Covers Assertion Based Design, Verification & Debug; •Includes language-based modeling and design techniques for embedded systems; •Covers design, modeling and verification of mixed physical domain and mixed signal systems; •Includes formal and semi-formal system level design methods for complex embedded systems based on the Unified Modelling Language (UML) and Model Driven Engineering (MDE); •Covers parallel architectures – both as platforms f...

  18. A Review of Dental Implant Treatment Planning and Implant Design Based on Bone Density

    Directory of Open Access Journals (Sweden)

    Torkzaban

    2013-06-01

    Full Text Available Context A key determinant for clinical success is the diagnosis of the bone density in a potential implant site. The percentage of bone-implant contact is related to bone density, and the axial stress contours around an implant are affected by the density of bone. Evidence Acquisition A number of reports have emphasized the importance of the quality of bone on the survival of dental implants. The volume and density of the recipient bone have also been shown to be determining criteria to establish proper treatment plans with adequate number of implants and sufficient surface area. Previous clinical reports that did not alter the protocol of treatment related to bone density had variable survival rates. To the contrary, altering the treatment plan to compensate for soft bone types has provided similar survival rates in all bone densities. Results When bone density decreases and bone become softer, the implant surface in contact with the bone decreases, therefore treatment plan should be modified by changing the drilling protocol, using gradual loading and reducing the force on the prosthesis or increasing the loading area with increasing implant number, implant position, implant size, implant design (deeper and more threads with more pitch, squared shape and implant body surface condition. Conclusions Once the prosthetic option, key implant position, and patient force factors have been determined, the bone density in the implant sites should be evaluated to modify the treatment plan. Inappropriate implant number or design in poor quality bone results in higher failure rates. Changing the treatment plan and implant design is suggested, based on bone density to achieve higher survival rates.

  19. Planning Coverage Campaigns for Mission Design and Analysis: CLASP for DESDynl

    Science.gov (United States)

    Knight, Russell L.; McLaren, David A.; Hu, Steven

    2013-01-01

    Mission design and analysis presents challenges in that almost all variables are in constant flux, yet the goal is to achieve an acceptable level of performance against a concept of operations, which might also be in flux. To increase responsiveness, automated planning tools are used that allow for the continual modification of spacecraft, ground system, staffing, and concept of operations, while returning metrics that are important to mission evaluation, such as area covered, peak memory usage, and peak data throughput. This approach was applied to the DESDynl mission design using the CLASP planning system, but since this adaptation, many techniques have changed under the hood for CLASP, and the DESDynl mission concept has undergone drastic changes. The software produces mission evaluation products, such as memory highwater marks, coverage percentages, given a mission design in the form of coverage targets, concept of operations, spacecraft parameters, and orbital parameters. It tries to overcome the lack of fidelity and timeliness of mission requirements coverage analysis during mission design. Previous techniques primarily use Excel in ad hoc fashion to approximate key factors in mission performance, often falling victim to overgeneralizations necessary in such an adaptation. The new program allows designers to faithfully represent their mission designs quickly, and get more accurate results just as quickly.

  20. Next generation safeguards initiative (NGSI) program plan for safeguards by design

    Energy Technology Data Exchange (ETDEWEB)

    Demuth, Scott F [Los Alamos National Laboratory; Budlong - Sylvester, Kory [Los Alamos National Laboratory; Lockwood, Dunbar [DOE/NA-243

    2010-01-01

    Safeguards by Design (SBD) is defined as the incorporation of safeguards features early in the design phase of a new nuclear facility in order to avoid the need to redesign the facility at a later date, or retrofit the completed facility. Not only can SBD avoid the need for redesign or retrofit, but consideration of safeguards features early in the facility design effort can provide for a more efficient and effective safeguards design. A program has been initiated by the United States Department of Energy during the past several years to develop, demonstrate and institutionalization SBD. This plan has been developed in parallel with a similar effort at the IAEA while taking into account their achievements and future plans. The United States SBD program is focused on (1) identification of best practices that satisfy existing safeguards requirements, (2) identification of advanced concepts where best practices can be improved, and (3) institutionalizing SBD by gaining its acceptance as a global norm for the design of new nuclear facilities. SBD guidance documents are being prepared as an aid to industry for their design activities, to describe the relationship between requirements, best practices, and advanced concepts. SBD 'lessons learned' studies have been conducted to help identify the existing best practices and potential areas for improvement. Finally, acceptance as a global norm is being pursued by way of international workshops, engagement with industry and the IAEA, and setting an example by way of its use in new nuclear facilities in the United States.

  1. Literature Review of Domestic Research on Tourism Landscape Design Planning and Design%国内旅游景观规划设计研究综述

    Institute of Scientific and Technical Information of China (English)

    高宏鑫; 张述林; 夏冬林

    2015-01-01

    The research on tourism landscape planning and design has increasingly emphasized the rapid improvement of tourism and further development of tourism planning system theory. Many domestic scholars have carried out research around the multi-faceted in the field. Based on analysis and consolidation of recent literature research published in domestic journals , this study conducted a review and evaluation on domestic tourism landscape planning and design. It summarized six aspects of research focus: tourism landscape planning and design theory, culture with tourism landscape planning and design, tourism landscape planning and design of rural region, method of tourism landscape planning and design, tourism landscape planning and design development arising problems and countermeasures , the future directions of tourism landscape planning and design. After that, the author has made some comments on the current research in this field and also made several references in order to provide some inspiration on tourism landscape planning and design research.%基于近些年发表于国内刊物上相关研究文献的整理与分析,对国内旅游景观规划设计研究内容进行了回顾与评析,总结出六个方面的研究关注点:旅游景观规划设计的理论、旅游景观规划设计与文化、乡村地域旅游景观规划设计、旅游景观规划设计方法、旅游景观规划设计发展中产生的问题与对策和旅游景观规划设计未来发展方向,并对研究工作提出了三点建议。

  2. Plan for the design, development, and implementation, and operation of the National Water Information System

    Science.gov (United States)

    Edwards, M.D.

    1987-01-01

    The Water Resources Division of the U.S. Geological Survey is developing a National Water Information System (NWIS) that will integrate and replace its existing water data and information systems of the National Water Data Storage and Retrieval System, National Water Data Exchange, National Water-Use Information, and Water Resources Scientific Information Center programs. It will be a distributed data system operated as part of the Division 's Distributed Information System, which is a network of computers linked together through a national telecommunication network known as GEONET. The NWIS is being developed as a series of prototypes that will be integrated as they are completed to allow the development and implementation of the system in a phased manner. It also is being developed in a distributed manner using personnel who work under the coordination of a central NWIS Project Office. Work on the development of the NWIS began in 1983 and it is scheduled for completion in 1990. This document presents an overall plan for the design, development, implementation, and operation of the system. Detailed discussions are presented on each of these phases of the NWIS life cycle. The planning, quality assurance, and configuration management phases of the life cycle also are discussed. The plan is intended to be a working document for use by NWIS management and participants in its design and development and to assist offices of the Division in planning and preparing for installation and operation of the system. (Author 's abstract)

  3. HAL/SM system functional design specification. [systems analysis and design analysis of central processing units

    Science.gov (United States)

    Ross, C.; Williams, G. P. W., Jr.

    1975-01-01

    The functional design of a preprocessor, and subsystems is described. A structure chart and a data flow diagram are included for each subsystem. Also a group of intermodule interface definitions (one definition per module) is included immediately following the structure chart and data flow for a particular subsystem. Each of these intermodule interface definitions consists of the identification of the module, the function the module is to perform, the identification and definition of parameter interfaces to the module, and any design notes associated with the module. Also described are compilers and computer libraries.

  4. Engaging Gatekeepers, Optimizing Decision Making, and Mitigating Bias: Design Specifications for Systemic Diversity Interventions.

    Science.gov (United States)

    Vinkenburg, Claartje J

    2017-06-01

    In this contribution to the Journal of Applied Behavioral Science Special Issue on Understanding Diversity Dynamics in Systems: Social Equality as an Organization Change Issue, I develop and describe design specifications for systemic diversity interventions in upward mobility career systems, aimed at optimizing decision making through mitigating bias by engaging gatekeepers. These interventions address the paradox of meritocracy that underlies the surprising lack of diversity at the top of the career pyramid in these systems. I ground the design specifications in the limited empirical evidence on "what works" in systemic interventions. Specifically, I describe examples from interventions in academic settings, including a bias literacy program, participatory modeling, and participant observation. The design specifications, paired with inspirational examples of successful interventions, should assist diversity officers and consultants in designing and implementing interventions to promote the advancement to and representation of nondominant group members at the top of the organizational hierarchy.

  5. System design specification Brayton Isotope Power System (BIPS) Flight System (FS), and Ground Demonstration System (GDS)

    Energy Technology Data Exchange (ETDEWEB)

    1976-06-14

    The system design specification for ground demonstration, development, and flight qualification of a Brayton Isotope Power System (BIPS) is presented. The requirements for both a BIPS conceptual Flight System (FS) and a Ground Demonstration System (GDS) are defined.

  6. Reliability-Based Design and Planning of Inspection and Monitoring of Offshore Wind Turbines

    DEFF Research Database (Denmark)

    Marquez-Dominguez, Sergio

    Maintaining and developing a sustainable wind industry is the main motivation of this PhD thesis entitled “Reliability-based design and planning of inspection and monitoring of offshore wind turbines”. In this thesis, statistical methods and probability theory are important mathematical tools used...... and offshore wind turbine foundations with the aim of improving the design, decreasing structural costs and increasing benefits. Recently, wind energy technology has started to adopt risk and reliability based inspection planning (RBI) as a methodology based on Bayesian decision theories together...... produced by the natural phenomena, i.e. wind and waves. This load interaction has an important influence on the dynamical behaviour as well as on the fatigue damage of the wind turbine structure, influencing its reliability and stability. In summation, wind, currents and sea loads can be considered...

  7. Planning staff training design%员工培训设计策划

    Institute of Scientific and Technical Information of China (English)

    陈公行

    2014-01-01

    a scientific staff training needs through careful planning design. First of all, to determine the training objectives, design and then can carry out training courses, and choose a suitable training methods, training teacher's role can not be ignored, according to the last write a complete training plan.%一个科学的员工培训需要经过周密的设计策划。首先要确定培训的目标,然后才能够进行培训课程的设计,同时还有选择一个合适的培训方法,培训师的作用也不可忽视,根据这些最后编写有一个完整的培训计划书。

  8. CONVEX CONTROLLER DESIGN APPLIED TO AC INDUCTION MOTOR TO SATISFY MULTIPLE SIMULTANEOUS SPECIFICATIONS

    Institute of Scientific and Technical Information of China (English)

    LEE Seung-Ju; SUN Dong; MILLS James K

    2006-01-01

    The application of a closed-loop specification oriented feedback control design method,which addresses the design of controllers to satisfy multiple simultaneous conflicting closed-loop performance specifications is presented. The proposed approach is well suited to the design of controllers which must meet a set of conflicting performance specifications. Gain tuning is central to the design process, however, the tuning process is greatly simplified over that presented by the problem of tuning a PID controller for example. The proposed control method is applied to an AC induction motor, with an inner-loop flux vector controller applied to design a position control system. Experimental results verify the effectiveness of this method.

  9. Exploiting linkage information and problem-specific knowledge in evolutionary distribution network expansion planning

    NARCIS (Netherlands)

    N.H. Luong (Ngoc Hoang); J.A. La Poutré (Han); P.A.N. Bosman (Peter)

    2017-01-01

    textabstractThis article tackles the Distribution Network Expansion Planning (DNEP) problem that has to be solved by distribution network operators to decide which, where, and/or when enhancements to electricity networks should be introd uced to satisfy the future power demands. Because of many

  10. Plans and Specifications for a Full-Scale Towing Model Validation Experiment

    Science.gov (United States)

    1989-05-01

    extreme tension statistics of towing hawsers. Doctoral dissertation, Massachusetts Institute of Technology, Department of Ocean Engineering, Cambridge...ship’s speed, as read from the installed speed log, every ten minutes 135 TESI PLAN - NAVSEA TWO BODY TOWING EXPERIMENT 3. Environmental Data a. Log wind

  11. Better Educational Website Interface Design: The Implications from Gender-Specific Preferences in Graduate Students

    Science.gov (United States)

    Hsu, Yu-chang

    2006-01-01

    This study investigated graduate students gender-specific preferences for certain website interface design features, intending to generate useful information for instructors in choosing and for website designers in creating educational websites. The features investigated in this study included colour value, major navigation buttons placement, and…

  12. 11. Strategic planning.

    Science.gov (United States)

    2014-05-01

    There are several types of planning processes and plans, including strategic, operational, tactical, and contingency. For this document, operational planning includes tactical planning. This chapter examines the strategic planning process and includes an introduction into disaster response plans. "A strategic plan is an outline of steps designed with the goals of the entire organisation as a whole in mind, rather than with the goals of specific divisions or departments". Strategic planning includes all measures taken to provide a broad picture of what must be achieved and in which order, including how to organise a system capable of achieving the overall goals. Strategic planning often is done pre-event, based on previous experience and expertise. The strategic planning for disasters converts needs into a strategic plan of action. Strategic plans detail the goals that must be achieved. The process of converting needs into plans has been deconstructed into its components and includes consideration of: (1) disaster response plans; (2) interventions underway or planned; (3) available resources; (4) current status vs. pre-event status; (5) history and experience of the planners; and (6) access to the affected population. These factors are tempered by the local: (a) geography; (b) climate; (c) culture; (d) safety; and (e) practicality. The planning process consumes resources (costs). All plans must be adapted to the actual conditions--things never happen exactly as planned.

  13. Single Event Testing on Complex Devices: Test Like You Fly Versus Test-Specific Design Structures

    Science.gov (United States)

    Berg, Melanie D.; Label, Kenneth

    2016-01-01

    We present a mechanism for evaluating complex digital systems targeted for harsh radiation environments such as space. Focus is limited to analyzing the single event upset (SEU) susceptibility of designs implemented inside Field Programmable Gate Array (FPGA) devices. Tradeoffs are provided between application-specific versus test-specific test structures.

  14. Optimal multitrial prediction combination and subject-specific adaptation for minimal training brain switch designs

    NARCIS (Netherlands)

    Spyrou, L.; Blokland, Y.M.; Farquhar, J.D.R.; Bruhn, J.

    2016-01-01

    Brain-Computer Interface systems are traditionally designed by taking into account user-specific data to enable practical use. More recently, subject independent (SI) classification algorithms have been developed which bypass the subject specific adaptation and enable rapid use of the system. A brai

  15. Single Event Testing on Complex Devices: Test Like You Fly versus Test-Specific Design Structures

    Science.gov (United States)

    Berg, Melanie; LaBel, Kenneth A.

    2014-01-01

    We present a framework for evaluating complex digital systems targeted for harsh radiation environments such as space. Focus is limited to analyzing the single event upset (SEU) susceptibility of designs implemented inside Field Programmable Gate Array (FPGA) devices. Tradeoffs are provided between application-specific versus test-specific test structures.

  16. Integral stormwater management master plan and design in an ecological community.

    Science.gov (United States)

    Che, Wu; Zhao, Yang; Yang, Zheng; Li, Junqi; Shi, Man

    2014-09-01

    Urban stormwater runoff nearly discharges directly into bodies of water through gray infrastructure in China, such as sewers, impermeable ditches, and pump stations. As urban flooding, water shortage, and other environment problems become serious, integrated water environment management is becoming increasingly complex and challenging. At more than 200ha, the Oriental Sun City community is a large retirement community located in the eastern side of Beijing. During the beginning of its construction, the project faced a series of serious water environment crises such as eutrophication, flood risk, water shortage, and high maintenance costs. To address these issues, an integral stormwater management master plan was developed based on the concept of low impact development (LID). A large number of LID and green stormwater infrastructure (GSI) approaches were designed and applied in the community to replace traditional stormwater drainage systems completely. These approaches mainly included bioretention (which captured nearly 85th percentile volume of the annual runoff in the site, nearly 5.4×10(5)m(3) annually), swales (which functioned as a substitute for traditional stormwater pipes), waterscapes, and stormwater wetlands. Finally, a stormwater system plan was proposed by integrating with the gray water system, landscape planning, an architectural master plan, and related consultations that supported the entire construction period. After more than 10 years of planning, designing, construction, and operation, Oriental Sun City has become one of the earliest modern large-scale LID communities in China. Moreover, the project not only addressed the crisis efficiently and effectively, but also yielded economic and ecological benefits.

  17. Ftklipse - Design and Implementation of an Extendable Computer Forensics Environment: Specification Design Document

    CERN Document Server

    Laverdière, Marc-André; Tsapa, Suhasini; Benredjem, Djamel

    2009-01-01

    The purpose of this work is to design and implement a plugin-based environment that allows to integrate forensic tools working together to support programming tasks and addition of new tools. Integration is done through GUI components. The end-system environment must have user friendly GUI, configuration capabilities, plug-in capabilities to insert/inject new tools, case management, and chain of custody capabilities, along with evidence gathering capabilities, evidence preservation capabilities, and, finally report generation capabilities. A subset of these requirements has been implemented in Ftklipse, an open-source project, which is detailed throughout the rest of this document.

  18. Informing General CSCW Product Development through Cooperative Design in Specific Work Domains

    DEFF Research Database (Denmark)

    Grønbæk, Kaj; Mogensen, Preben Holst

    1997-01-01

    and general development activities supported transfer of work domain knowledge into general features of the product being developed. Mutual challenging characterized the interaction between specific cooperative analysis and design activities and general development activities. Prototypes, scenarios, materials......Cooperative analysis and design is often considered only to be applicable in settings where a system is being developed solely for the ’user‘ participants in the process. This paper, however, argues that there are quite good prospects in applying cooperative analysis and design techniques...... in specific use settings to inform development of general CSCW products. We describe and discuss the application of cooperative – i.e., participatory – analysis and design techniques in a project developing a general cooperative hypermedia framework as well as specific hypermedia applications to support...

  19. Designing specific protein-protein interactions using computation, experimental library screening, or integrated methods.

    Science.gov (United States)

    Chen, T Scott; Keating, Amy E

    2012-07-01

    Given the importance of protein-protein interactions for nearly all biological processes, the design of protein affinity reagents for use in research, diagnosis or therapy is an important endeavor. Engineered proteins would ideally have high specificities for their intended targets, but achieving interaction specificity by design can be challenging. There are two major approaches to protein design or redesign. Most commonly, proteins and peptides are engineered using experimental library screening and/or in vitro evolution. An alternative approach involves using protein structure and computational modeling to rationally choose sequences predicted to have desirable properties. Computational design has successfully produced novel proteins with enhanced stability, desired interactions and enzymatic function. Here we review the strengths and limitations of experimental library screening and computational structure-based design, giving examples where these methods have been applied to designing protein interaction specificity. We highlight recent studies that demonstrate strategies for combining computational modeling with library screening. The computational methods provide focused libraries predicted to be enriched in sequences with the properties of interest. Such integrated approaches represent a promising way to increase the efficiency of protein design and to engineer complex functionality such as interaction specificity.

  20. Development of the Plan for Improvement of the Competitiveness of KALIMER Design against the Competing Reactor Design in Gen IV

    Energy Technology Data Exchange (ETDEWEB)

    Sim, Yoon Sub; Kim, Yeong Il; Hong, Ser Gi (and others)

    2005-11-15

    A fast reactor has a good transmutation capability and it enables breeding of fuel and use of a closed fuel cycle. By these characteristics of a fast reactor, the limited uranium resources of the world can be much more effectively utilized and the nuclear wastes of a high level of radioactivity and toxicity from the current nuclear power reactors of LWRs and HWRs can be drastically reduced in its volume and the management of the wastes can be easily treated. Also electricity can be generated more effectively since a fast reactor has the feature of high operation temperature. These features of a fast reactor makes it inevitable on a long term basis to construct fast reactors in Korea. The domestic fast reactor technology level, however, is at the level of coming out of a beginning stage and needs utilization of international expertise. Recently an international cooperation program called GIF has been formulated and our KALIMER was selected as one of the two reference designs for the international joint R and D works with JSFR of Japan. In the current frame of the GIF program, the two selected reference designs are supposed to be evaluated against each other in future and one design is to be finally selected. To make the international cooperation program directed more useful to our fast reactor technology development, it is required to strengthen the competitiveness of KALIMER so that it can be selected. To meet the necessity, a study was made to enhance the competitiveness of KALIMER. The design characteristics of JSFR was investigated and relatively weak points and strong points of KALIMER were identified. Also the GenIV SFR design requirements were applied to two designs to evaluate the level of requirements satisfaction. Based on these investigation results, a plan for improving the weak features and strengthening the strong points of the KALIMER design has been developed.

  1. Patient specific quality assurance of RapidArc pre treatment plans using semiflex 0.125 cc ionization chamber

    Science.gov (United States)

    Kumar, S. A. Syam; Vivekanandan, Nagarajan

    2017-01-01

    Patient specific pre-treatment quality assurance for RapidArc plans were analyzed for hundred patients for different sites. Verification plan was created for each treatment plan in Eclipse 8.6 treatment planning system with the semiflex ionization chamber and the octavius phantom. Absolute point dose were measured for head and neck, thorax and abdomen cases using semiflex (0.125 cc) ionization chamber. Positive absolute mean dose variation of 0.56% was observed with thorax cases with a standard deviation (SD) of ±1.13 between the plans with a range of -1.78% to 2.70%. Negative percentage dose errors were found with head and neck and abdomen cases, with a mean variation of -0.43% (SD±1.50), (range -3.25% to 2.85%) and -0.35% (SD±1.48), (range -3.10% to 2.65%) for head and neck and abdomen cases respectively. Evaluation has been done using PTW verisoft software by keeping the passing criteria as 3 mm DTA, 3% DD, for 95% of the evaluated dose points. The maximum percentage value failed in gamma analysis was found to be 4.95, 4.75, and 4.88 for head and neck, thorax, and abdomen cases respectively. In all the cases analyzed the percentage dose points failed the gamma criteria is less than 5%. On the basis of the studies performed it can be concluded that the semiflex ionization chamber having a volume of 0.125 cc can be used efficiently for measuring the pre-treatment quality assurance of RapidArc plans for all the sites.

  2. Planning Considerations for a Mars Sample Receiving Facility: Summary and Interpretation of Three Design Studies

    Science.gov (United States)

    Beaty, David W.; Allen, Carlton C.; Bass, Deborah S.; Buxbaum, Karen L.; Campbell, James K.; Lindstrom, David J.; Miller, Sylvia L.; Papanastassiou, Dimitri A.

    2009-10-01

    It has been widely understood for many years that an essential component of a Mars Sample Return mission is a Sample Receiving Facility (SRF). The purpose of such a facility would be to take delivery of the flight hardware that lands on Earth, open the spacecraft and extract the sample container and samples, and conduct an agreed-upon test protocol, while ensuring strict containment and contamination control of the samples while in the SRF. Any samples that are found to be non-hazardous (or are rendered non-hazardous by sterilization) would then be transferred to long-term curation. Although the general concept of an SRF is relatively straightforward, there has been considerable discussion about implementation planning. The Mars Exploration Program carried out an analysis of the attributes of an SRF to establish its scope, including minimum size and functionality, budgetary requirements (capital cost, operating costs, cost profile), and development schedule. The approach was to arrange for three independent design studies, each led by an architectural design firm, and compare the results. While there were many design elements in common identified by each study team, there were significant differences in the way human operators were to interact with the systems. In aggregate, the design studies provided insight into the attributes of a future SRF and the complex factors to consider for future programmatic planning.

  3. Planning considerations for a Mars Sample Receiving Facility: summary and interpretation of three design studies.

    Science.gov (United States)

    Beaty, David W; Allen, Carlton C; Bass, Deborah S; Buxbaum, Karen L; Campbell, James K; Lindstrom, David J; Miller, Sylvia L; Papanastassiou, Dimitri A

    2009-10-01

    It has been widely understood for many years that an essential component of a Mars Sample Return mission is a Sample Receiving Facility (SRF). The purpose of such a facility would be to take delivery of the flight hardware that lands on Earth, open the spacecraft and extract the sample container and samples, and conduct an agreed-upon test protocol, while ensuring strict containment and contamination control of the samples while in the SRF. Any samples that are found to be non-hazardous (or are rendered non-hazardous by sterilization) would then be transferred to long-term curation. Although the general concept of an SRF is relatively straightforward, there has been considerable discussion about implementation planning. The Mars Exploration Program carried out an analysis of the attributes of an SRF to establish its scope, including minimum size and functionality, budgetary requirements (capital cost, operating costs, cost profile), and development schedule. The approach was to arrange for three independent design studies, each led by an architectural design firm, and compare the results. While there were many design elements in common identified by each study team, there were significant differences in the way human operators were to interact with the systems. In aggregate, the design studies provided insight into the attributes of a future SRF and the complex factors to consider for future programmatic planning.

  4. 住宅小区规划设计%Planning and Designing of Residential District

    Institute of Scientific and Technical Information of China (English)

    陈云

    2014-01-01

    With the development of urbanization, higher re-quirements in the planning and designing of residential district are put forward with the growing material and cultural needs. This paper introduces the basic features and elements of the planning and designing of residential district, analyzes the pro-blems existing in the residential district planning, puts forward the corresponding optimization countermeasures, which has a certain reference value.%随着城市化进程不断推进,日益增长的物质文化需求对住宅小区的规划设计提出了更高的要求。本文介绍了住宅小区规划设计的基本特点和要素,分析了住宅小区规划中存在的问题,提出了相应的优化对策,具有一定的借鉴价值。

  5. From ergonomics to design specifications: contributions to the design of a processing machine in a tire company.

    Science.gov (United States)

    Moraes, A S P; Arezes, P M; Vasconcelos, R

    2012-01-01

    The development of ergonomics' recommendations, guidelines and standards are attempts to promote the integration of ergonomics into industrial contexts. Such developments result from several sources and professionals and represent the effort that has been done to develop healthier and safer work environments. However, the availability of large amount of data and documents regarding ergonomics does not guarantee their applicability. The main goal of this paper is to use a specific case to demonstrate how ergonomics criteria were developed in order to contribute to the design of workplaces. Based on the obtained results from research undertaken in a tire company, it was observed that the ergonomics criteria should be presented as design specifications in order to be used by engineers and designers. In conclusion, it is observed that the multiple constraint environment impeded the appliance of the ergonomics criteria. It was also observed that the knowledge on technical design and the acquaintance with ergonomic standards, the level of integration in the design team, and the ability to communicate with workers and other technical staff have paramount importance in integrating ergonomics criteria into the design process.

  6. Design Process of a Campus Plan: A Case Study of Duzce University Konuralp Campus

    Directory of Open Access Journals (Sweden)

    Ozgur Yerli

    2017-04-01

    Full Text Available Humanity have always felt the need to alter the environment they inhabit. In our modern era, this desire continues to exhibit itself in more urban landscapes. As a microcosm of the cityscape, university campuses contribute many cultural and economic advantages to the urban population. Moreover they bring under control to the urban growth and generally provides open and green spaces to the city. In this paper, Düzce University Konuralp Campus, located north of the Düzce City, was considered as our study area. Here we describe the Konuralp campus design which was developed in "Duzce University Konuralp Campus Development Plan Urban Design Competition". The method of the study consist of three steps. Some analyses like location, topography (ecological wind corridors and the meeting point of the valleys, spatial zoning, design axes and circulation were performed at the first step. In the second step it has been tried to specify how to apply the steps for designing kind of these campus projects. The concept of the design was created and constructed for the project. In the last step the design was visualized with 3D aplications and presented here. The aim of the study is how to design a campus which is sustainable and accessible. Consequently, the campus design was realized which had some design principles based on pedestrian priority. Educational buildings were separated from social buildings, sports center and cultural centers by using a-pedestrian walkways. In the middle of the working area campus square was designed which contains some land uses such as ceremony area, student center, amphitheatre and library. Finally a sustainable and accessible campus design was developed for Duzce University.

  7. Educational Specifications for Administrative and Support Areas in School Buildings: Considerations in Planning.

    Science.gov (United States)

    Everett, Ronald E.

    1986-01-01

    Educational specifications should contain the following factors for each activity space: objectives, activities, persons to be accommodated, space requirements, spatial relationships, equipment, and special environmental treatments. A list of specifics for administrative areas and food service areas are representative of decisions that must be…

  8. Design-based stereology: Planning, volumetry and sampling are crucial steps for a successful study.

    Science.gov (United States)

    Tschanz, Stefan; Schneider, Jan Philipp; Knudsen, Lars

    2014-01-01

    Quantitative data obtained by means of design-based stereology can add valuable information to studies performed on a diversity of organs, in particular when correlated to functional/physiological and biochemical data. Design-based stereology is based on a sound statistical background and can be used to generate accurate data which are in line with principles of good laboratory practice. In addition, by adjusting the study design an appropriate precision can be achieved to find relevant differences between groups. For the success of the stereological assessment detailed planning is necessary. In this review we focus on common pitfalls encountered during stereological assessment. An exemplary workflow is included, and based on authentic examples, we illustrate a number of sampling principles which can be implemented to obtain properly sampled tissue blocks for various purposes. Copyright © 2013 Elsevier GmbH. All rights reserved.

  9. Statistical issues in quality control of proteomic analyses: good experimental design and planning.

    Science.gov (United States)

    Cairns, David A

    2011-03-01

    Quality control is becoming increasingly important in proteomic investigations as experiments become more multivariate and quantitative. Quality control applies to all stages of an investigation and statistics can play a key role. In this review, the role of statistical ideas in the design and planning of an investigation is described. This involves the design of unbiased experiments using key concepts from statistical experimental design, the understanding of the biological and analytical variation in a system using variance components analysis and the determination of a required sample size to perform a statistically powerful investigation. These concepts are described through simple examples and an example data set from a 2-D DIGE pilot experiment. Each of these concepts can prove useful in producing better and more reproducible data. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  10. Development of an integrated CAD-FEA system for patient-specific design of spinal cages.

    Science.gov (United States)

    Zhang, Mingzheng; Pu, Fang; Xu, Liqiang; Zhang, Linlin; Liang, Hang; Li, Deyu; Wang, Yu; Fan, Yubo

    2017-03-01

    Spinal cages are used to create a suitable mechanical environment for interbody fusion in cases of degenerative spinal instability. Due to individual variations in bone structures and pathological conditions, patient-specific cages can provide optimal biomechanical conditions for fusion, strengthening patient recovery. Finite element analysis (FEA) is a valuable tool in the biomechanical evaluation of patient-specific cage designs, but the time- and labor-intensive process of modeling limits its clinical application. In an effort to facilitate the design and analysis of patient-specific spinal cages, an integrated CAD-FEA system (CASCaDeS, comprehensive analytical spinal cage design system) was developed. This system produces a biomechanical-based patient-specific design of spinal cages and is capable of rapid implementation of finite element modeling. By comparison with commercial software, this system was validated and proven to be both accurate and efficient. CASCaDeS can be used to design patient-specific cages with a superior biomechanical performance to commercial spinal cages.

  11. Optimization Model and Algorithm Design for Airline Fleet Planning in a Multiairline Competitive Environment

    Directory of Open Access Journals (Sweden)

    Yu Wang

    2015-01-01

    Full Text Available This paper presents a multiobjective mathematical programming model to optimize airline fleet size and structure with consideration of several critical factors severely affecting the fleet planning process. The main purpose of this paper is to reveal how multiairline competitive behaviors impact airline fleet size and structure by enhancing the existing route-based fleet planning model with consideration of the interaction between market share and flight frequency and also by applying the concept of equilibrium optimum to design heuristic algorithm for solving the model. Through case study and comparison, the heuristic algorithm is proved to be effective. By using the algorithm presented in this paper, the fleet operational profit is significantly increased compared with the use of the existing route-based model. Sensitivity analysis suggests that the fleet size and structure are more sensitive to the increase of fare price than to the increase of passenger demand.

  12. Planning and design of a green city in Kaixian for population relocation of Three Gorges Project

    Institute of Scientific and Technical Information of China (English)

    ZENG Wei; JIANG Jia-long; John KOCH-SCHULTE; Neol LEE

    2008-01-01

    We describe the green space system planning and design of a new Kaixian City for migrants in the Three Gorges Reservoir area of P.R.China. The goal of the project was to provide a high quality settlement for migrants relocated from the old Kaixian City that had a history of over one thousand years and from other places with different traditional cultures. Our efforts focused on conceiving affordable strategies to increase green areas, improve waterfront landscapes, deal with water level fluctuation,integrate diverse folk cultures, and encourage bicycling as an environmentally-friendly form of urban transportation.The new city is anticipated to benefit from the green space systems with an improved eco-environment, enriched tourism resources, cheap landscaping costs, relief from traffic pressure, and in other ways. The planning philosophies employed could be useful in the engineering and construction of other cities in the Three Gorges Reservoir area.

  13. GRAPHICS DATA STRUCTURES IN MICROCOMPUTER AIDED DESIGN FOR OPEN PIT PLANNING

    Institute of Scientific and Technical Information of China (English)

    吴力心

    1991-01-01

    This paper discribes the importance and necessity of the study on the data structures for displaying the mining field using the interactive technology in open pit design and planning,based upon the grid block model. The commonly used data structures--rectangular array structure and quadtree structure ,are analyzed. Two compressed data structures--compressed circular link array structure and compressed doubly-linked circular array structure,are proposed,which are much more suitable for displaying the regularly gridded block model. When the two compressed data structures are adopted,the storage space can be tremendously saved and the algorithms are simple,while the requirements of the accuracy and the manipulating speed will be both satisfied for the interactive open pit short range plan formulation.

  14. Nez Perce Tribal Hatchery Project; Operations and Maintenance and Planning and Design, 2002 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Larson, Roy Edward; Walker, Grant W.; Penney, Aaron K. (Nez Perce Tribe, Lapwai, ID)

    2005-12-01

    This report fulfills the contract obligations based on the Statement of Work (SOW) for the project as contracted with Bonneville Power Administration (BPA). Nez Perce Tribal Hatchery (NPTH) Year-2002 annual report combines information from two contracts with a combined value of $3,036,014. Bonneville Power Administration identifies them as follows; (1) Part I--Operations and Maintenance--Project No. 1983-350-00, Contract No. 4504, and $2,682,635 which includes--Equipment costs of $1,807,105. (2) Part II--Planning and Design--Project No. 1983-35-04, Contract No. 4035, $352,379 for Clearwater Coho Restoration Master Plan development Based on NPPC authorization for construction and operation of NPTH, the annual contracts were negotiated for the amounts shown above under (1) and (2). Construction contracts were handled by BPA until all facilities are completed and accepted.

  15. Specification and Design of Electrical Flight System Architectures with SysML

    Science.gov (United States)

    McKelvin, Mark L., Jr.; Jimenez, Alejandro

    2012-01-01

    Modern space flight systems are required to perform more complex functions than previous generations to support space missions. This demand is driving the trend to deploy more electronics to realize system functionality. The traditional approach for the specification, design, and deployment of electrical system architectures in space flight systems includes the use of informal definitions and descriptions that are often embedded within loosely coupled but highly interdependent design documents. Traditional methods become inefficient to cope with increasing system complexity, evolving requirements, and the ability to meet project budget and time constraints. Thus, there is a need for more rigorous methods to capture the relevant information about the electrical system architecture as the design evolves. In this work, we propose a model-centric approach to support the specification and design of electrical flight system architectures using the System Modeling Language (SysML). In our approach, we develop a domain specific language for specifying electrical system architectures, and we propose a design flow for the specification and design of electrical interfaces. Our approach is applied to a practical flight system.

  16. Five features of value-based insurance design plans were associated with higher rates of medication adherence.

    Science.gov (United States)

    Choudhry, Niteesh K; Fischer, Michael A; Smith, Benjamin F; Brill, Gregory; Girdish, Charmaine; Matlin, Olga S; Brennan, Troyen A; Avorn, Jerry; Shrank, William H

    2014-03-01

    Value-based insurance design (VBID) plans selectively lower cost sharing to increase medication adherence. Existing plans have been structured in a variety of ways, and these variations could influence the effectiveness of VBID plans. We evaluated seventy-six plans introduced by a large pharmacy benefit manager during 2007-10. We found that after we adjusted for the other features and baseline trends, VBID plans that were more generous, targeted high-risk patients, offered wellness programs, did not offer disease management programs, and made the benefit available only for medication ordered by mail had a significantly greater impact on adherence than plans without these features. The effects were as large as 4-5 percentage points. These findings can provide guidance for the structure of future VBID plans.

  17. Incorporating operational flexibility into electric generation planning Impacts and methods for system design and policy analysis

    Science.gov (United States)

    Palmintier, Bryan S.

    This dissertation demonstrates how flexibility in hourly electricity operations can impact long-term planning and analysis for future power systems, particularly those with substantial variable renewables (e.g., wind) or strict carbon policies. Operational flexibility describes a power system's ability to respond to predictable and unexpected changes in generation or demand. Planning and policy models have traditionally not directly captured the technical operating constraints that determine operational flexibility. However, as demonstrated in this dissertation, this capability becomes increasingly important with the greater flexibility required by significant renewables (>= 20%) and the decreased flexibility inherent in some low-carbon generation technologies. Incorporating flexibility can significantly change optimal generation and energy mixes, lower system costs, improve policy impact estimates, and enable system designs capable of meeting strict regulatory targets. Methodologically, this work presents a new clustered formulation that tractably combines a range of normally distinct power system models, from hourly unit-commitment operations to long-term generation planning. This formulation groups similar generators into clusters to reduce problem size, while still retaining the individual unit constraints required to accurately capture operating reserves and other flexibility drivers. In comparisons against traditional unit commitment formulations, errors were generally less than 1% while run times decreased by several orders of magnitude (e.g., 5000x). Extensive numerical simulations, using a realistic Texas-based power system show that ignoring flexibility can underestimate carbon emissions by 50% or result in significant load and wind shedding to meet environmental regulations. Contributions of this dissertation include: 1. Demonstrating that operational flexibility can have an important impact on power system planning, and describing when and how these

  18. Site characterization plan conceptual design report for a high-level nuclear waste repository in salt, vertical emplacement mode: Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    1987-12-01

    This Conceptual Design Report describes the conceptual design of a high-level nuclear waste repository in salt at a proposed site in Deaf Smith County, Texas. Waste receipt, processing, packing, and other surface facility operations are described. Operations in the shafts underground are described, including waste hoisting, transfer, and vertical emplacement. This report specifically addresses the vertical emplacement mode, the reference design for the repository. Waste retrieval capability is described. The report includes a description of the layout of the surface, shafts, and underground. Major equipment items are identified. The report includes plans for decommissioning and sealing of the facility. The report discusses how the repository will satisfy performance objectives. Chapters are included on basis for design, design analyses, and data requirements for completion of future design efforts. 105 figs., 52 tabs.

  19. Custom-Designed Molecular Scissors for Site-Specific Manipulation of the Plant and Mammalian Genomes

    Science.gov (United States)

    Kandavelou, Karthikeyan; Chandrasegaran, Srinivasan

    Zinc finger nucleases (ZFNs) are custom-designed molecular scissors, engineered to cut at specific DNA sequences. ZFNs combine the zinc finger proteins (ZFPs) with the nonspecific cleavage domain of the FokI restriction enzyme. The DNA-binding specificity of ZFNs can be easily altered experimentally. This easy manipulation of the ZFN recognition specificity enables one to deliver a targeted double-strand break (DSB) to a genome. The targeted DSB stimulates local gene targeting by several orders of magnitude at that specific cut site via homologous recombination (HR). Thus, ZFNs have become an important experimental tool to make site-specific and permanent alterations to genomes of not only plants and mammals but also of many other organisms. Engineering of custom ZFNs involves many steps. The first step is to identify a ZFN site at or near the chosen chromosomal target within the genome to which ZFNs will bind and cut. The second step is to design and/or select various ZFP combinations that will bind to the chosen target site with high specificity and affinity. The DNA coding sequence for the designed ZFPs are then assembled by polymerase chain reaction (PCR) using oligonucleotides. The third step is to fuse the ZFP constructs to the FokI cleavage domain. The ZFNs are then expressed as proteins by using the rabbit reticulocyte in vitro transcription/translation system and the protein products assayed for their DNA cleavage specificity.

  20. Design for Additive Bio-Manufacturing: From Patient-Specific Medical Devices to Rationally Designed Meta-Biomaterials

    Directory of Open Access Journals (Sweden)

    Amir A. Zadpoor

    2017-07-01

    Full Text Available Recent advances in additive manufacturing (AM techniques in terms of accuracy, reliability, the range of processable materials, and commercial availability have made them promising candidates for production of functional parts including those used in the biomedical industry. The complexity-for-free feature offered by AM means that very complex designs become feasible to manufacture, while batch-size-indifference enables fabrication of fully patient-specific medical devices. Design for AM (DfAM approaches aim to fully utilize those features for development of medical devices with substantially enhanced performance and biomaterials with unprecedented combinations of favorable properties that originate from complex geometrical designs at the micro-scale. This paper reviews the most important approaches in DfAM particularly those applicable to additive bio-manufacturing including image-based design pipelines, parametric and non-parametric designs, metamaterials, rational and computationally enabled design, topology optimization, and bio-inspired design. Areas with limited research have been identified and suggestions have been made for future research. The paper concludes with a brief discussion on the practical aspects of DfAM and the potential of combining AM with subtractive and formative manufacturing processes in so-called hybrid manufacturing processes.

  1. Design for Additive Bio-Manufacturing: From Patient-Specific Medical Devices to Rationally Designed Meta-Biomaterials.

    Science.gov (United States)

    Zadpoor, Amir A

    2017-07-25

    Recent advances in additive manufacturing (AM) techniques in terms of accuracy, reliability, the range of processable materials, and commercial availability have made them promising candidates for production of functional parts including those used in the biomedical industry. The complexity-for-free feature offered by AM means that very complex designs become feasible to manufacture, while batch-size-indifference enables fabrication of fully patient-specific medical devices. Design for AM (DfAM) approaches aim to fully utilize those features for development of medical devices with substantially enhanced performance and biomaterials with unprecedented combinations of favorable properties that originate from complex geometrical designs at the micro-scale. This paper reviews the most important approaches in DfAM particularly those applicable to additive bio-manufacturing including image-based design pipelines, parametric and non-parametric designs, metamaterials, rational and computationally enabled design, topology optimization, and bio-inspired design. Areas with limited research have been identified and suggestions have been made for future research. The paper concludes with a brief discussion on the practical aspects of DfAM and the potential of combining AM with subtractive and formative manufacturing processes in so-called hybrid manufacturing processes.

  2. Design for Additive Bio-Manufacturing: From Patient-Specific Medical Devices to Rationally Designed Meta-Biomaterials

    Science.gov (United States)

    Zadpoor, Amir A.

    2017-01-01

    Recent advances in additive manufacturing (AM) techniques in terms of accuracy, reliability, the range of processable materials, and commercial availability have made them promising candidates for production of functional parts including those used in the biomedical industry. The complexity-for-free feature offered by AM means that very complex designs become feasible to manufacture, while batch-size-indifference enables fabrication of fully patient-specific medical devices. Design for AM (DfAM) approaches aim to fully utilize those features for development of medical devices with substantially enhanced performance and biomaterials with unprecedented combinations of favorable properties that originate from complex geometrical designs at the micro-scale. This paper reviews the most important approaches in DfAM particularly those applicable to additive bio-manufacturing including image-based design pipelines, parametric and non-parametric designs, metamaterials, rational and computationally enabled design, topology optimization, and bio-inspired design. Areas with limited research have been identified and suggestions have been made for future research. The paper concludes with a brief discussion on the practical aspects of DfAM and the potential of combining AM with subtractive and formative manufacturing processes in so-called hybrid manufacturing processes. PMID:28757572

  3. [Sampling plan, weighting process and design effects of the Brazilian Oral Health Survey].

    Science.gov (United States)

    Silva, Nilza Nunes da; Roncalli, Angelo Giuseppe

    2013-12-01

    To present aspects of the sampling plan of the Brazilian Oral Health Survey (SBBrasil Project). with theoretical and operational issues that should be taken into account in the primary data analyses. The studied population was composed of five demographic groups from urban areas of Brazil in 2010. Two and three stage cluster sampling was used. adopting different primary units. Sample weighting and design effects (deff) were used to evaluate sample consistency. In total. 37,519 individuals were reached. Although the majority of deff estimates were acceptable. some domains showed distortions. The majority (90%) of the samples showed results in concordance with the precision proposed in the sampling plan. The measures to prevent losses and the effects the cluster sampling process in the minimum sample sizes proved to be effective for the deff. which did not exceeded 2. even for results derived from weighting. The samples achieved in the SBBrasil 2010 survey were close to the main proposals for accuracy of the design. Some probabilities proved to be unequal among the primary units of the same domain. Users of this database should bear this in mind, introducing sample weighting in calculations of point estimates, standard errors, confidence intervals and design effects.

  4. Design and performance analysis of global path planning techniques for autonomous mobile robots in grid environments

    Directory of Open Access Journals (Sweden)

    Imen Chaari

    2017-03-01

    Full Text Available This article presents the results of the 2-year iroboapp research project that aims at devising path planning algorithms for large grid maps with much faster execution times while tolerating very small slacks with respect to the optimal path. We investigated both exact and heuristic methods. We contributed with the design, analysis, evaluation, implementation and experimentation of several algorithms for grid map path planning for both exact and heuristic methods. We also designed an innovative algorithm called relaxed A-star that has linear complexity with relaxed constraints, which provides near-optimal solutions with an extremely reduced execution time as compared to A-star. We evaluated the performance of the different algorithms and concluded that relaxed A-star is the best path planner as it provides a good trade-off among all the metrics, but we noticed that heuristic methods have good features that can be exploited to improve the solution of the relaxed exact method. This led us to design new hybrid algorithms that combine our relaxed A-star with heuristic methods which improve the solution quality of relaxed A-star at the cost of slightly higher execution time, while remaining much faster than A* for large-scale problems. Finally, we demonstrate how to integrate the relaxed A-star algorithm in the robot operating system as a global path planner and show that it outperforms its default path planner with an execution time 38% faster on average.

  5. Specific Modifications to Contract Policy for Staff Members and Project Associates related to the Human Resources Plan and LHC Completion

    CERN Document Server

    2003-01-01

    As agreed at the Committee meetings last December, the Management hereby submits two specific proposals to adjust staff contract policy and a third concerning appointments of Project Associates, following indications given in the Human Resources Plan presented last December. These proposals are limited to changes which are urgently required for the implementation of the HR Plan and the completion of the LHC. Other aspects concerning contract policy, raised by Internal Task Force 4 last year, and in particular the policy and procedures governing the award of indefinite contracts, require more in-depth study on which the Management will report progress on the clarification of these wider policy issues later in the year to TREF. After discussion at TREF in February 2003, the Management hereby submits these proposals for approval by the Finance Committee (paragraph 2.1 below) and by the Council (paragraphs 2.2 and 3.1 below), for entry into force on 1 April 2003.

  6. Using Space Weather Variability in Evaluating the Radiation Environment Design Specifications for NASA's Constellation Program

    Science.gov (United States)

    Coffey, Victoria N.; Blackwell, William C.; Minow, Joseph I.; Bruce, Margaret B.; Howard, James W.

    2007-01-01

    NASA's Constellation program, initiated to fulfill the Vision for Space Exploration, will create a new generation of vehicles for servicing low Earth orbit, the Moon, and beyond. Space radiation specifications for space system hardware are necessarily conservative to assure system robustness for a wide range of space environments. Spectral models of solar particle events and trapped radiation belt environments are used to develop the design requirements for estimating total ionizing radiation dose, displacement damage, and single event effects for Constellation hardware. We first describe the rationale using the spectra chosen to establish the total dose and single event design environmental specifications for Constellation systems. We then compare variability of the space environment to the spectral design models to evaluate their applicability as conservative design environments and potential vulnerabilities to extreme space weather events

  7. A Strategy for Material-specific e-Textile Interaction Design

    DEFF Research Database (Denmark)

    Gowrishankar, Ramyah; Bredies, Katharina; Ylirisku, Salu

    2017-01-01

    The interaction design of e-Textile products are often characterized by conventions adopted from electronic devices rather than developing interactions that can be specific to e-Textiles. We argue that textile materials feature a vast potential for the design of novel digital interactions....... Especially the shape-reformation capabilities of textiles may inform the design of expressive and aesthetically rewarding applications. In this chapter, we propose ways in which the textileness of e-Textiles can be better harnessed. We outline an e-Textile Interaction Design strategy that is based...... on defining the material-specificity of e-Textiles as its ability to deform in ways that match the expectations we have of textile materials. It embraces an open-ended exploration of textile-related interactions (for e.g. stretching, folding, turning-inside-out etc.) and their potential for electronic...

  8. SU-E-T-120: Analytic Dose Verification for Patient-Specific Proton Pencil Beam Scanning Plans

    Energy Technology Data Exchange (ETDEWEB)

    Chang, C; Mah, D [ProCure Proton Therapy Centers, Somerset, NJ (United States)

    2015-06-15

    Purpose: To independently verify the QA dose of proton pencil beam scanning (PBS) plans using an analytic dose calculation model. Methods: An independent proton dose calculation engine is created using the same commissioning measurements as those employed to build our commercially available treatment planning system (TPS). Each proton PBS plan is exported from the TPS in DICOM format and calculated by this independent dose engine in a standard 40 x 40 x 40 cm water tank. This three-dimensional dose grid is then compared with the QA dose calculated by the commercial TPS, using standard Gamma criterion. A total of 18 measured pristine Bragg peaks, ranging from 100 to 226 MeV, are used in the model. Intermediate proton energies are interpolated. Similarly, optical properties of the spots are measured in air over 15 cm upstream and downstream, and fitted to a second-order polynomial. Multiple Coulomb scattering in water is approximated analytically using Preston and Kohler formula for faster calculation. The effect of range shifters on spot size is modeled with generalized Highland formula. Note that the above formulation approximates multiple Coulomb scattering in water and we therefore chose not use the full Moliere/Hanson form. Results: Initial examination of 3 patient-specific prostate PBS plans shows that agreement exists between 3D dose distributions calculated by the TPS and the independent proton PBS dose calculation engine. Both calculated dose distributions are compared with actual measurements at three different depths per beam and good agreements are again observed. Conclusion: Results here showed that 3D dose distributions calculated by this independent proton PBS dose engine are in good agreement with both TPS calculations and actual measurements. This tool can potentially be used to reduce the amount of different measurement depths required for patient-specific proton PBS QA.

  9. Designs of precoding for LTE TDD using cell specific reference signals

    DEFF Research Database (Denmark)

    Sun, Fan; Lu, Lu; Sørensen, Troels Bundgaard

    2010-01-01

    We design non-codebook-based Multiple-Input Multiple-Output (MIMO) precoding schemes using multiple cell-specific reference signals patterns for the time division duplex (TDD) mode of LTE, where channel reciprocity can be exploited. Previously proposed non-codebookbased precoding schemes typically...... use UE specific reference signals for demodulation. Cell specific reference signals are however always allocated for the transmission of common control signalling, mobility measurements and downlink channel quality measurements. In order to save the resources occupied by UE specific reference signals......, and to simplify UE implementation, a precoder-estimation scheme and a codebook-assisted scheme are designed. The codebook-assisted scheme has the novelty of using a codebook in equalization. Link throughput simulations indicate that the codebook-assisted scheme is preferable compared to the precoder...

  10. Designing patient-specific 3D printed craniofacial implants using a novel topology optimization method.

    Science.gov (United States)

    Sutradhar, Alok; Park, Jaejong; Carrau, Diana; Nguyen, Tam H; Miller, Michael J; Paulino, Glaucio H

    2016-07-01

    Large craniofacial defects require efficient bone replacements which should not only provide good aesthetics but also possess stable structural function. The proposed work uses a novel multiresolution topology optimization method to achieve the task. Using a compliance minimization objective, patient-specific bone replacement shapes can be designed for different clinical cases that ensure revival of efficient load transfer mechanisms in the mid-face. In this work, four clinical cases are introduced and their respective patient-specific designs are obtained using the proposed method. The optimized designs are then virtually inserted into the defect to visually inspect the viability of the design . Further, once the design is verified by the reconstructive surgeon, prototypes are fabricated using a 3D printer for validation. The robustness of the designs are mechanically tested by subjecting them to a physiological loading condition which mimics the masticatory activity. The full-field strain result through 3D image correlation and the finite element analysis implies that the solution can survive the maximum mastication of 120 lb. Also, the designs have the potential to restore the buttress system and provide the structural integrity. Using the topology optimization framework in designing the bone replacement shapes would deliver surgeons new alternatives for rather complicated mid-face reconstruction.

  11. Integration of social vulnerability into emergency management plans: designing of evacuation routes against flood disasters

    Science.gov (United States)

    Aroca-Jimenez, Estefanía; Bodoque, Jose Maria; Garcia, Juan Antonio; Diez-Herrero, Andres

    2017-04-01

    Flash floods are highly spatio-temporal localized flood events characterized by reaching a high peak flow in a very short period of time, i.e., generally with times of concentration lower than six hours. Its short duration, which limits or even voids any warning time, means that flash floods are considered to be one of the most destructive natural hazards with the greatest capacity to generate risk, either in terms of the number of people affected globally or the proportion of individual fatalities. The above highlights the importance of a realistic and appropriate design of evacuation strategies in order to reduce flood-related losses, being evacuation planning considered of critical importance for disaster management. Traditionally, evacuation maps have been based on flood-prone areas, shelters or emergency residences location and evacuation routes information. However, evacuation plans rarely consider the spatial distribution of vulnerable population (i.e., people with special needs, mobility constraints or economic difficulties), which usually require assistance from emergency responders. The goal of this research is to elaborate an evacuation map against the occurrence of flash floods by combining geographic information (e.g. roads, health facilities location, sanitary helicopters) and social vulnerability patterns, which are previously obtained from socioeconomic variables (e.g. population, unemployment, dwelling characteristics). To do this, ArcGis Network Analyst tool is used, which allows to calculate the optimal evacuation routes. The methodology proposed here is implemented in the region of Castilla y León (94,230 km2). Urban areas prone to flash flooding are identified taking into account the following requirements: i) city centers are crossed by rivers or streams with a longitudinal slope higher than 0.01 m m-1; ii) city centers are potentially affected by flash floods; and iii) city centers are affected by an area with low or exceptional probability

  12. Integrating the theory of planned behavior and attitude functions: implications for health campaign design.

    Science.gov (United States)

    Wang, Xiao

    2009-07-01

    This study argues that the integration of the theory of planned behavior and attitude functions can provide a more detailed theoretical explanation and more precise practical guidance regarding behavioral prediction. Relying on a survey of 549 undergraduate students, this research found that individuals' intentions to regularly participate in physical activity were predicted by their utilitarian and self-esteem maintenance attitudes, the effects of which were further moderated by individuals' strength of self-monitoring and self-esteem, respectively. In addition to theoretical implications, this research indicates that campaign planners should consider the use of more-detailed attitude constructs and design functionally matched messages according to the target's personality traits.

  13. How do Teachers Design a Class about Stereotypes?--An Analysis of a Lesson Plan

    Institute of Scientific and Technical Information of China (English)

    郑哲; 田琳

    2015-01-01

    Due to the development of international trade, an increasing number of Africans immigrated to Guangzhou in China. At the same time, most Chinese locals’impressions of Africans come from media, friends and family, which could result in stereo⁃typed stories (Byram, 1997, p. 36). Under this circumstance, the paper designs and analyzes a lesson plan which aims at challeng⁃ing university students’stereotypes of the Africans in Guangzhou. Through the analysis, some suggestions are proposed to facilitate the conduct of the similar culture class and the limitations are outlined.

  14. Application of multiple criteria decision methods in space exploration initiative design and planning

    Science.gov (United States)

    Masud, Abu S. M.

    1991-01-01

    Fellowship activities were directed towards the identification of opportunities for application of the Multiple Criteria Decision Making (MCDM) techniques in the Space Exploration Initiative (SEI) domain. I identified several application possibilities and proposed demonstration application in these three areas: evaluation and ranking of SEI architectures, space mission planning and selection, and space system design. Here, only the first problem is discussed. The most meaningful result of the analysis is the wide separation between the two top ranked architectures, indicating a significant preference difference between them. It must also be noted that the final ranking reflects, to some extent, the biases of the evaluators and their understanding of the architecture.

  15. Smile design and treatment planning with the help of a comprehensive esthetic evaluation form.

    Science.gov (United States)

    Calamia, John R; Levine, Jonathan B; Lipp, Mitchell; Cisneros, George; Wolff, Mark S

    2011-04-01

    Even if a clinician possesses basic knowledge in esthetic dentistry and clinical skills, many cases presenting in modern dental practices simply cannot be restored to both the clinician's and the patient's expectations without incorporating the perspectives and assistance of several dental disciplines. Besides listening carefully to chief complaints, clinicians must also be able to evaluate the patient's physical, biologic, and esthetic needs. This article demonstrates the use of a smile evaluation form designed at New York University that assists in developing esthetic treatment plans that might incorporate any and all dental specialties in a simple and organized fashion.

  16. Design and evaluation of a specific primer pair for the diagnosis and identification of Acanthamoeba polyphaga.

    Science.gov (United States)

    Ortega-Rivas, Antonio; Lorenzo-Morales, Jacob; Martinez-Carretero, Enrique; Villa Lloberas, Mercedes; Valladares Hernández, Basilio; del Castillo-Remiro, Antonio

    2004-05-01

    Random amplified polymorphism DNA (RAPD) is a useful tool for species identification. The obtained band patterns can be used for specific primer pair design that may be useful for species diagnosis. In this study, a distinctive a 962-bp band in A. polyphaga band patterns was found, by using the OPC20 primer (ACTTCGCCAC). The DNA fragment was used to design a specific primer pair that was useful for the identification of different isolates as A. polyphaga species. A case of A. polyphaga in disseminated acanthamoebiasis affecting mesenteric nodes is also reported.

  17. Method for Predicting the Energy Characteristics of Li-Ion Cells Designed for High Specific Energy

    Science.gov (United States)

    Bennett, William, R.

    2012-01-01

    Novel electrode materials with increased specific capacity and voltage performance are critical to the NASA goals for developing Li-ion batteries with increased specific energy and energy density. Although performance metrics of the individual electrodes are critically important, a fundamental understanding of the interactions of electrodes in a full cell is essential to achieving the desired performance, and for establishing meaningful goals for electrode performance in the first place. This paper presents design considerations for matching positive and negative electrodes in a viable design. Methods for predicting cell-level performance, based on laboratory data for individual electrodes, are presented and discussed.

  18. Mod-5A wind turbine generator program design report. Volume 4: Drawings and specifications, book 3

    Science.gov (United States)

    1984-01-01

    The design, development and analysis of the 7.3 MW MOD-5A wind turbine generator is documented. This volume contains the drawings and specifications developed for the final design. This volume is divided into 5 books of which this is the third, containing drawings 47A380074 through 47A380126. A full breakdown parts listing is provided as well as a where used list.

  19. Environmental Restoration and Waste Management Site-Specific Plan for Fiscal Year 1993

    Energy Technology Data Exchange (ETDEWEB)

    1993-03-01

    The Idaho National Engineering Laboratory (INEL) is a US Department of Energy (DOE) multiprogram laboratory whose primary mission has been to research nuclear technologies. Working with these technologies and conducting other types of research generates waste, including radioactive and/or hazardous wastes. While most of the waste treatment, storage, and disposal practices have been effective, some practices have led to the release of contaminants to the environment. As a result, DOE has developed (1) an Environmental Restoration (ER) Program to identify and, where necessary, cleanup releases from inactive waste sites and (2) a Waste Management (WM) Program to safely treat, store, and dispose of DOE wastes generated from current and future activities in an environmentally sound manner. This document describes the plans for FY 1993 for the INEL`s ER and WM programs as managed by DOE`s Idaho Field Office (DOE-ID).

  20. Climate Change, Coastal Vulnerability and the Need for Adaptation Alternatives: Planning and Design Examples from Egypt and the USA

    OpenAIRE

    S Jeffress Williams; Nabil Ismail

    2015-01-01

    Planning and design of coastal protection for high-risk events with low to moderate or uncertain probabilities are a challenging balance of short- and long-term cost vs. protection of lives and infrastructure. The pervasive, complex, and accelerating impacts of climate change on coastal areas, including sea-level rise, storm surge and tidal flooding, require full integration of the latest science into strategic plans and engineering designs. While the impacts of changes occurring are global, ...

  1. Planning and Design of Botanical Garden%植物园的规划设计及要点

    Institute of Scientific and Technical Information of China (English)

    李增宝

    2016-01-01

    从选址、分区两个大方面论述了植物园的规划设计应遵循的原则,并从七个具体方面阐述了植物园规划设计要点。%This paper discusses the planning and design of the botanical garden from two aspects,the seven aspects of the planning and design of the botanical garden.

  2. AN INNOVATIVE APPROACH FOR PLANNING AND EXECUTION OF PRE-EXPERIMENTAL RUNS FOR DESIGN OF EXPERIMENTS

    Directory of Open Access Journals (Sweden)

    Arsalan Farooq, Muhammad

    2016-09-01

    Full Text Available This paper addresses the study of the pre-experimental planning phase of the Design of Experiments (DoE in order to improve the final product quality. The pre-experimental planning phase includes a clear identification of the problem statement, selection of control factors and their respective levels and ranges. To improve production quality based on the DoE a new approach for the pre-experimental planning phase, called Non-Conformity Matrix (NCM, is presented. This article also addresses the key steps of the pre-experimental runs considering a consumer goods manufacturing process. Results of the application for an industrial case show thatthis methodology can support a clear definition ofthe problem and also a correct identification of the factor ranges in particular situations. The proposed new approach allows modeling the entire manufacturing system holistically and correctly defining the factor ranges and respective levels for a more effective application of DoE. This new approach can be a useful resource for both research and industrial practitioners who are dedicated to large DoE projects with unknown factor interactions, when the operational levels and ranges are not completely defined.

  3. Review: Improving the Impact of Plant Science on Urban Planning and Design

    Directory of Open Access Journals (Sweden)

    Peter C. Wootton-Beard

    2016-11-01

    Full Text Available Urban planning is a vital process in determining the functionality of future cities. It is predicted that at least two thirds of the world’s citizens will reside in towns and cities by the middle of this century, up from one third in the middle of the previous century. Not only is it essential to provide space for work and dwelling, but also for their well-being. Well-being is inextricably linked with the surrounding environment, and natural landscapes have a potent positive effect. For this reason, the inclusion and management of urban green infrastructure has become a topic of increasing scientific interest. Elements of this infrastructure, including green roofs and façades are of growing importance to operators in each stage of the planning, design and construction process in urban areas. Currently, there is a strong recognition that “green is good”. Despite the positive recognition of urban greenery, and the concerted efforts to include more of it in cities, greater scientific attention is needed to better understand its role in the urban environment. For example, many solutions are cleverly engineered without giving sufficient consideration to the biology of the vegetation that is used. This review contends that whilst “green is good” is a positive mantra to promote the inclusion of urban greenery, there is a significant opportunity to increase the contribution of plant science to the process of urban planning through both green infrastructure, and biomimicry.

  4. MAHIS-based analysis and design of financial investment planning system

    Institute of Scientific and Technical Information of China (English)

    Ren Guisheng; Li Chunsheng

    2008-01-01

    In financial investment planning, a large number of components that interact in varying and complex ways are involved. This leads to complex behavior that is difficult to understand, predict and manage. A single intelligent technique can not solve the complicated and elaborate investment planning problems. It is necessary to study those problems synthetically by combining the multiple intelligent techniques. We employed fussy algorithms, genetic algorithms, etc. to solve complicated financial portfolio management in this paper. We analyse and design an agent-based hybrid intelligent system by following the methodology for constructing agent-based hybrid intelligent system (MAHIS). The system starts with the financial risk tolerance evaluation based on fussy algorithms. Asset allocation, portfolio selections, interest predictions, and ordered weighted averaging can be conducted by using hybrid intelligent techniques. The planning agent in the system can easily access all the intelligent processing agents, including the agents of financial risk tolerance assessment, asset allocation, portfolio selection, interest prediction, and decision aggregation. Overall system robustness is facilitated.

  5. Study on Site Specific Design Earthquake Ground Motion of Nuclear Power Plants in China1

    Institute of Scientific and Technical Information of China (English)

    Zhou Bochang; Li Xiaojun; Li Yaqi

    2008-01-01

    The main technical backgrounds and requirements are introduced with regard to earthquake ground motion design parameters in several domestic and American standards,codes and guides involved in the seismic analysis and design activities of nuclear power plants in China.Based on the research results from site seismic safety evaluation of domestic nuclear power plant projects in the last years,characteristics and differences of site specific design spectra are analyzed in comparison with standard response spectra,and the suitability of standard response spectra for domestic nuclear power plant projects is discussed.

  6. Mod-5A Wind Turbine Generator Program Design Report. Volume 4: Drawings and Specifications, Book 1

    Science.gov (United States)

    1984-01-01

    The design, development and analysis of the 7.3 MW MOD-5A wind turbine generator is documented. Volume 4 contains the drawings and specifications that were developed in preparation for building the MOD-5A wind turbine generator. This is the first of five books of volume four. It contains structural design criteria, generator step-up transformer specs, specs for design, fabrication and testing of the system, specs for the ground control enclosure, systems specs, slip ring specs, and control system specs.

  7. Application of objective provision tree to development of standard review plan for sodium-cooled fast reactor nuclear design

    Energy Technology Data Exchange (ETDEWEB)

    Bae, Moo-Hoon; Suh, Namduk; Choi, Yongwon; Shin, Andong [Korea Institute of Nuclear Safety, Daejon (Korea, Republic of)

    2016-06-15

    A systematic methodology was developed for the standard review plan for sodium-cooled fast reactor nuclear design. The process is first to develop an objective provision tree of sodium-cooled fast reactor for the reactivity control safety function. The provision tree is generally developed by designer to confirm whether the design satisfies the defense-in-depth concept. Then applicability of the current standard review plan of nuclear design for light water reactor to sodium-cooled fast reactor was evaluated and complemented by the developed objective provision tree.

  8. Patient-Specific Simulation of Implant Placement and Function for Cochlear Implantation Surgery Planning

    DEFF Research Database (Denmark)

    Ceresa, Mario; Mangado Lopez, Nerea; Dejea Velardo, Hector;

    2014-01-01

    We present a framework for patient specific electrical stimulation of the cochlea, that allows to perform in-silico analysis of implant placement and function before surgery. A Statistical Shape Model (SSM) is created from high-resolution human μCT data to capture important anatomical details...

  9. Management of business process design in global implementation of enterprise resource planning systems

    DEFF Research Database (Denmark)

    Rahimi, Fatemeh

    Investments in global enterprise resource planning (ERP) systems are typically carried out as a part of the globalization process in multinational corporations (MNCs). Global ERP systems support integration and control in MNCs in an important way by establishing a common language across an MNC....... As process and data standardization are among the primary drivers of ERP consolidation efforts, business process design is an important concern when implementing global ERP systems. This PhD study addresses three research questions that develop understanding, support, and improvement of the practice...... of business process design in the course of a global ERP implementation in MNCs. In light of existing theoretical and practical challenges, the research questions focus on three business process management (BPM) capabilities: alignment, governance, and method. Drawing on extensive literature reviews...

  10. New Design of Mobile Robot Path Planning with Randomly Moving Obstacles

    Directory of Open Access Journals (Sweden)

    T. A. Salih

    2013-05-01

    Full Text Available The navigation of a mobile robot in an unknown environment has always been a very challenging task. In order to achieve safe and autonomous navigation, the mobile robot needs to sense the surrounding environment and plans a collision-free path. This paper focuses on designing and implementing a mobile robot which has the ability of navigating smoothly in an unknown environment, avoiding collisions, without having to stop in front of obstacles, detecting leakage of combustible gases and transmitting a message of detection results to the civil defense unit automatically through the Internet to the E-mail. This design uses the implementation of artificial neural network (ANN on a new technology represented by Field Programmable Analog Array (FPAA for controlling the motion of the robot. The robot with the proposed controller is tested and has completed the required objective successfully.

  11. A tool for design of primers for microRNA-specific quantitative RT-qPCR.

    Science.gov (United States)

    Busk, Peter K

    2014-01-28

    MicroRNAs are small but biologically important RNA molecules. Although different methods can be used for quantification of microRNAs, quantitative PCR is regarded as the reference that is used to validate other methods. Several commercial qPCR assays are available but they often come at a high price and the sequences of the primers are not disclosed. An alternative to commercial assays is to manually design primers but this work is tedious and, hence, not practical for the design of primers for a larger number of targets. I have developed the software miRprimer for automatic design of primers for the method miR-specific RT-qPCR, which is one of the best performing microRNA qPCR methods available. The algorithm is based on an implementation of the previously published rules for manual design of miR-specific primers with the additional feature of evaluating the propensity of formation of secondary structures and primer dimers. Testing of the primers showed that 76 out of 79 primers (96%) worked for quantification of microRNAs by miR-specific RT-qPCR of mammalian RNA samples. This success rate corresponds to the success rate of manual primer design. Furthermore, primers designed by this method have been distributed to several labs and used successfully in published studies. The software miRprimer is an automatic and easy method for design of functional primers for miR-specific RT-qPCR. The application is available as stand-alone software that will work on the MS Windows platform and in a developer version written in the Ruby programming language.

  12. Using Behavioral Science to Design a Peer Comparison Intervention for Postabortion Family Planning in Nepal.

    Science.gov (United States)

    Spring, Hannah; Datta, Saugato; Sapkota, Sabitri

    2016-01-01

    Despite the provision of free and subsidized family planning services and clients' demonstrated intentions to delay pregnancies, family planning uptake among women who receive abortion and postabortion services at Sunaulo Parivar Nepal (SPN), one of Nepal's largest non-governmental sexual and reproductive health (SRH) providers, remains low. Through meetings, interviews, and observations with SPN's stakeholders, service providers, and clients at its 36 SRH centers, we developed hypotheses about client- and provider-side barriers that may inhibit postabortion family planning (PAFP) uptake. On the provider side, we found that the lack of benchmarks (such as the performance of other facilities) against which providers could compare their own performance and the lack of feedback on the performance were important barriers to PAFP uptake. We designed several variants of three interventions to address these barriers. Through conversations with team members at SPN's centralized support office and service providers at SPN centers, we prioritized a peer-comparison tool that allows providers at one center to compare their performance with that of other similar centers. We used feedback from the community of providers on the tools' usability and features to select a variant of the tool that also leverages and reinforces providers' strong intrinsic motivation to provide quality PAFP services. In this paper, we detail the process of identifying barriers and creating an intervention to overcome those barriers. The intervention's effectiveness will be tested with a center-level, stepped-wedge randomized control trial in which SPN's 36 centers will be randomly assigned to receive the intervention at 1-month intervals over a 6-month period. Existing medical record data will be used to monitor family planning uptake.

  13. Assessing cost-effectiveness of specific LID practice designs in response to large storm events

    Science.gov (United States)

    Chui, Ting Fong May; Liu, Xin; Zhan, Wenting

    2016-02-01

    Low impact development (LID) practices have become more important in urban stormwater management worldwide. However, most research on design optimization focuses on relatively large scale, and there is very limited information or guideline regarding individual LID practice designs (i.e., optimal depth, width and length). The objective of this study is to identify the optimal design by assessing the hydrological performance and the cost-effectiveness of different designs of LID practices at a household or business scale, and to analyze the sensitivity of the hydrological performance and the cost of the optimal design to different model and design parameters. First, EPA SWMM, automatically controlled by MATLAB, is used to obtain the peak runoff of different designs of three specific LID practices (i.e., green roof, bioretention and porous pavement) under different design storms (i.e., 2 yr and 50 yr design storms of Hong Kong, China and Seattle, U.S.). Then, life cycle cost is estimated for the different designs, and the optimal design, defined as the design with the lowest cost and at least 20% peak runoff reduction, is identified. Finally, sensitivity of the optimal design to the different design parameters is examined. The optimal design of green roof tends to be larger in area but thinner, while the optimal designs of bioretention and porous pavement tend to be smaller in area. To handle larger storms, however, it is more effective to increase the green roof depth, and to increase the area of the bioretention and porous pavement. Porous pavement is the most cost-effective for peak flow reduction, followed by bioretention and then green roof. The cost-effectiveness, measured as the peak runoff reduction/thousand Dollars of LID practices in Hong Kong (e.g., 0.02 L/103 US s, 0.15 L/103 US s and 0.93 L/103 US s for green roof, bioretention and porous pavement for 2 yr storm) is lower than that in Seattle (e.g., 0.03 L/103 US s, 0.29 L/103 US s and 1.58 L/103 US s for

  14. Towards the formal specification of the requirements and design of a processor interface unit: HOL listings

    Science.gov (United States)

    Fura, David A.; Windley, Phillip J.; Cohen, Gerald C.

    1993-01-01

    This technical report contains the HOL listings of the specification of the design and major portions of the requirements for a commercially developed processor interface unit (or PIU). The PIU is an interface chip performing memory interface, bus interface, and additional support services for a commercial microprocessor within a fault-tolerant computer system. This system, the Fault-Tolerant Embedded Processor (FTEP), is targeted towards applications in avionics and space requiring extremely high levels of mission reliability, extended maintenance-free operation, or both. This report contains the actual HOL listings of the PIU specification as it currently exists. Section two of this report contains general-purpose HOL theories that support the PIU specification. These theories include definitions for the hardware components used in the PIU, our implementation of bit words, and our implementation of temporal logic. Section three contains the HOL listings for the PIU design specification. Aside from the PIU internal bus (I-Bus), this specification is complete. Section four contains the HOL listings for a major portion of the PIU requirements specification. Specifically, it contains most of the definition for the PIU behavior associated with memory accesses initiated by the local processor.

  15. A Practical Approach for Integrating Automatically Designed Fixtures with Automated Assembly Planning

    Energy Technology Data Exchange (ETDEWEB)

    Calton, Terri L.; Peters, Ralph R.

    1999-07-20

    This paper presents a practical approach for integrating automatically designed fixtures with automated assembly planning. Product assembly problems vary widely; here the focus is on assemblies that are characterized by a single base part to which a number of smaller parts and subassemblies are attached. This method starts with three-dimension at CAD descriptions of an assembly whose assembly tasks require a fixture to hold the base part. It then combines algorithms that automatically design assembly pallets to hold the base part with algorithms that automatically generate assembly sequences. The designed fixtures rigidly constrain and locate the part, obey task constraints, are robust to part shape variations, are easy to load, and are economical to produce. The algorithm is guaranteed to find the global optimum solution that satisfies these and other pragmatic conditions. The assembly planner consists of four main elements: a user interface, a constraint system, a search engine, and an animation module. The planner expresses all constraints at a sequencing level, specifying orders and conditions on part mating operations in a number of ways. Fast replanning enables an interactive plan-view-constrain-replan cycle that aids in constrain discovery and documentation. The combined algorithms guarantee that the fixture will hold the base part without interfering with any of the assembly operations. This paper presents an overview of the planners, the integration approach, and the results of the integrated algorithms applied to several practical manufacturing problems. For these problems initial high-quality fixture designs and assembly sequences are generated in a matter of minutes with global optimum solutions identified in just over an hour.

  16. Planning Coverage Campaigns for Mission Design and Analysis: Clasp for the Proposed DESDynI Mission

    Science.gov (United States)

    Knight, Russell; McLaren, David; Hu, Steven

    2012-01-01

    Mission design and analysis present challenges in that almost all variables are in constant flux, yet the goal is to achieve an acceptable level of performance against a concept of operations, which might also be in flux. To increase responsiveness, our approach is to use automated planning tools that allow for the continual modification of spacecraft, ground system, staffing, and concept of operations while returning metrics that are important to mission evaluation, such as area covered, peak memory usage, and peak data throughput. We have applied this approach to DESDynI (Deformation, Ecosystem Structure, and Dynamics of Ice) mission design concept using the CLASP (Compressed Large-scale Activity Scheduler/Planner) planning system [7], but since this adaptation many techniques have changed under the hood for CLASP and the DESDynI mission concept has undergone drastic changes, including that it has been renamed the Earth Radar Mission. Over the past two years, we have run more than fifty simulations with the CLASP-DESDynI adaptation, simulating different mission scenarios with changing parameters including targets, swaths, instrument modes, and data and downlink rates. We describe the evolution of simulations through the DESDynI MCR (Mission Concept Review) and afterwards.

  17. Water Resilience by Design: A water infrastructure planning framework for developing sustainable water management strategies

    Science.gov (United States)

    Brown, C.; Ray, P. A.; Freeman, S.

    2016-12-01

    Societal need for improved water management and concerns for the long-term sustainability of water resources systems are prominent around the world. The continued susceptibility of society to the harmful effects of hydrologic variability, pervasive concerns related to climate change and the emergent awareness of devastating effects of current practice on aquatic ecosystems all illustrate our limited understanding of how water ought to be managed in a dynamic world. To address these challenges, new problem solving approaches are required that acknowledge uncertainties, incorporate best available information, and link engineering design principles, typically based on determinism, with our best geoscience-based understanding of planetary change. In this presentation, we present and demonstrate a framework for developing water planning and management strategies that are resilient in the face of future uncertainties and our limited ability to anticipate the future. The approach begins with stakeholder engagement and decision framing to elicit relevant context, uncertainties, choices and connections that drive planning and serve as an entry point to exploring possible futures. The result is the development of water strategies that are informed by the best available predictive information and designed to perform well over a future of change. Examples from around the world are presented to illustrate the methodology.

  18. Visual design and verification tool for collision-free dexterous patient specific neurosurgical instruments

    Science.gov (United States)

    Hess, Maggie; Eastwood, Kyle; Linder, Bence; Bodani, Vivek; Lasso, Andras; Looi, Thomas; Fichtinger, Gabor; Drake, James

    2016-03-01

    PURPOSE: In many minimally invasive neurosurgical procedures, the surgical workspace is a small tortuous cavity that is accessed using straight, rigid instruments with limited dexterity. Specifically considering neuroendoscopy, it is often challenging for surgeons, using standard instruments, to reach multiple surgical targets from a single incision. To address this problem, continuum tools are under development to create highly dexterous minimally invasive instruments. However, this design process is not trivial, and therefore, a user-friendly design platform capable of easily incorporating surgeon input is needed. METHODS: We propose a method that uses simulation and visual verification to design continuum tools that are patient and procedure specific. Our software module utilizes pre-operative scans and virtual threedimensional (3D) patient models to intuitively aid instrument design. The user specifies basic tool parameters and the parameterized tools and trocar are modeled within the virtual patient. By selecting and dragging the instrument models, the tools are instantly reshaped and repositioned. The tool geometry and surgical entry points are then returned as outputs to undergo optimization. We have completed an initial validation of the software by comparing a simulation of a physical instrument's reachability to the corresponding virtual design. RESULTS AND CONCLUSION: The software was assessed qualitatively by two neurosurgeons, who design tools for an intraventricular endoscopic procedure. Further, validation experiments comparing the design of a virtual instrument to a physical tool demonstrate that the software module functions correctly. Thus, our platform permits user-friendly, application specific design of continuum instruments. These instruments will give surgeons much more flexibility in developing future minimally invasive procedures.

  19. Buffer Rod Design for Measurement of Specific Gravity in the Processing of Industrial Food Batters

    DEFF Research Database (Denmark)

    Fox, Paul D.; Smith, Penny Probert

    2002-01-01

    A low cost perspex buffer rod design for the measurement of specific gravity during the processing of industrial food batters is reported. Operation was conducted in pulsed mode using a 2.25 MHz, 15 mm diameter transducer and the intensity and an analytic calibration curve relating buffer rod...

  20. Progress report:Specifications and design criteria for innovative corrosion monitoring and (downhole) sensor systems

    NARCIS (Netherlands)

    Zhang, X.; Akemu, A.

    2010-01-01

    The objective of this sub-project is to establish specifications and design criteria for corrosion monitoring and corrosion sensor systems used in CO2 storage wells; this includes sensitivity analysis and an evaluation of technological maturity. In the Year 1 programme, we review the tools deployed

  1. Mod-5A wind turbine generator program design report. Volume 4: Drawings and specifications, book 5

    Science.gov (United States)

    1984-01-01

    The design, development and analysis of the 7.3 MW MOD-5A wind turbine generator is documented. There are four volumes. This volume contains the drawings and specifications that were developed in preparation for building the MOD-5A wind turbine generator. Detail drawings of several assemblies and subassemblies are given. This is the fifth book of volume 4.

  2. Production of specific structured lipids by enzymatic interesterification: optimization of the reaction by response surface design

    DEFF Research Database (Denmark)

    Xu, Xuebing; Skands, Anja Rebecca Havegaard; Adler-Nissen, Jens;

    1998-01-01

    Rapeseed oil and capric acid were interesterified in solvent-free media catalyzed by Lipozyme IM (Rhizomucor miehei) to produce specific-structured lipids (SSLs). The process was optimized by response surface design concerning the effects of acyl migration and the by-products of diacylglycerols...

  3. IMS Learning Design: How specifications could change the current e-learning landscape (in russian)

    NARCIS (Netherlands)

    Burgos, Daniel; Berbegal, Nidia; Griffiths, David; Tattersall, Colin; Koper, Rob

    2005-01-01

    Please refer to the original article: Burgos, D., Berbegal, N., Griffiths, D., Tattersall, C., Koper, Rob. (2005) IMS Learning Design: How specifications could change the current e-learning landscape, in e-Learning World, issue 2, March-April 2005. ISSN: 1811-069X. Moscow: Moscow State University

  4. Design, synthesis, and characterization of nucleosomes containing site-specific DNA damage.

    Science.gov (United States)

    Taylor, John-Stephen

    2015-12-01

    How DNA damaged is formed, recognized, and repaired in chromatin is an area of intense study. To better understand the structure activity relationships of damaged chromatin, mono and dinucleosomes containing site-specific damage have been prepared and studied. This review will focus on the design, synthesis, and characterization of model systems of damaged chromatin for structural, physical, and enzymatic studies.

  5. Site specific health and safety plan, 233-S decontamination and decommissioning

    Energy Technology Data Exchange (ETDEWEB)

    J. E. Fasso

    1997-12-31

    The deactivated 233-S Plutonium Concentration Facility, located in the 200 Area at the Hanford Site, is the subject of this Health and Safety Plan.The 233-S Facility operated from January 1952 until July 1967 at which time the building entered the U.S. Department of Energy`s Surplus Facility Management Program as a retired facility. The facility has since undergone severe degradation due to exposure to extreme weather conditions. Additionally, the weather caused existing cracks in concrete structures of the building to lengthen, thereby increasing the potential for failed confinement of the radioactive material in the building. Differential settlement has also occurred causing portions of the facility to separate from the main building structure, increasing the potential for release of radioactive material to the environment. An expedited response is proposed to remove this threat and ensure protection of human health and the environment. On this premise it is intended that the 233-S Facility removal action be performed as a Comprehensive Environmental Response, Compensation, and Liability Act of 1980 Time-Critical Project being conducted under the Pilot Hanford Environmental Restoration (ER) Initiative

  6. Classifications for Coastal Wetlands Planning, Protection and Restoration Act (CWPPRA) site-specific projects: 2010

    Science.gov (United States)

    Jones, William R.; Garber, Adrienne

    2013-01-01

    The Coastal Wetlands Planning, Protection and Restoration Act (CWPPRA) funds over 100 wetland restoration projects across Louisiana. Integral to the success of CWPPRA is its long-term monitoring program, which enables State and Federal agencies to determine the effectiveness of each restoration effort. One component of this monitoring program is the classification of high-resolution, color-infrared aerial photography at the U.S. Geological Survey’s National Wetlands Research Center in Lafayette, Louisiana. Color-infrared aerial photography (9- by 9-inch) is obtained before project construction and several times after construction. Each frame is scanned on a photogrametric scanner that produces a high-resolution image in Tagged Image File Format (TIFF). By using image-processing software, these TIFF files are then orthorectified and mosaicked to produce a seamless image of a project area and its associated reference area (a control site near the project that has common environmental features, such as marsh type, soil types, and water salinities.) The project and reference areas are then classified according to pixel value into two distinct classes, land and water. After initial land and water ratios have been established by using photography obtained before and after project construction, subsequent comparisons can be made over time to determine land-water change.

  7. Rational design of antibodies targeting specific epitopes within intrinsically disordered proteins

    Science.gov (United States)

    Sormanni, Pietro; Aprile, Francesco A.; Vendruscolo, Michele

    2015-01-01

    Antibodies are powerful tools in life sciences research, as well as in diagnostic and therapeutic applications, because of their ability to bind given molecules with high affinity and specificity. Using current methods, however, it is laborious and sometimes difficult to generate antibodies to target specific epitopes within a protein, in particular if these epitopes are not effective antigens. Here we present a method to rationally design antibodies to enable them to bind virtually any chosen disordered epitope in a protein. The procedure consists in the sequence-based design of one or more complementary peptides targeting a selected disordered epitope and the subsequent grafting of such peptides on an antibody scaffold. We illustrate the method by designing six single-domain antibodies to bind different epitopes within three disease-related intrinsically disordered proteins and peptides (α-synuclein, Aβ42, and IAPP). Our results show that all these designed antibodies bind their targets with good affinity and specificity. As an example of an application, we show that one of these antibodies inhibits the aggregation of α-synuclein at substoichiometric concentrations and that binding occurs at the selected epitope. Taken together, these results indicate that the design strategy that we propose makes it possible to obtain antibodies targeting given epitopes in disordered proteins or protein regions. PMID:26216991

  8. Rational design of antibodies targeting specific epitopes within intrinsically disordered proteins.

    Science.gov (United States)

    Sormanni, Pietro; Aprile, Francesco A; Vendruscolo, Michele

    2015-08-11

    Antibodies are powerful tools in life sciences research, as well as in diagnostic and therapeutic applications, because of their ability to bind given molecules with high affinity and specificity. Using current methods, however, it is laborious and sometimes difficult to generate antibodies to target specific epitopes within a protein, in particular if these epitopes are not effective antigens. Here we present a method to rationally design antibodies to enable them to bind virtually any chosen disordered epitope in a protein. The procedure consists in the sequence-based design of one or more complementary peptides targeting a selected disordered epitope and the subsequent grafting of such peptides on an antibody scaffold. We illustrate the method by designing six single-domain antibodies to bind different epitopes within three disease-related intrinsically disordered proteins and peptides (α-synuclein, Aβ42, and IAPP). Our results show that all these designed antibodies bind their targets with good affinity and specificity. As an example of an application, we show that one of these antibodies inhibits the aggregation of α-synuclein at substoichiometric concentrations and that binding occurs at the selected epitope. Taken together, these results indicate that the design strategy that we propose makes it possible to obtain antibodies targeting given epitopes in disordered proteins or protein regions.

  9. Individual characteristics of language learners in lesson planning for specific purposes

    Science.gov (United States)

    Ivleva, N. V.

    2016-04-01

    This paper provides a summary of internationally recognized methods and approaches in teaching foreign languages with the focus on teaching foreign languages for specific purposes. It also covers the idea of mastering a foreign language through knowing speech units which are necessary for individual language learners in the professional area with due regard to criteria provided by the author. The criteria were developed on the basis of the theory on adaptation of complex systems and also observation in the teaching process.

  10. Enriching Peptide Libraries for Binding Affinity and Specificity Through Computationally Directed Library Design.

    Science.gov (United States)

    Foight, Glenna Wink; Chen, T Scott; Richman, Daniel; Keating, Amy E

    2017-01-01

    Peptide reagents with high affinity or specificity for their target protein interaction partner are of utility for many important applications. Optimization of peptide binding by screening large libraries is a proven and powerful approach. Libraries designed to be enriched in peptide sequences that are predicted to have desired affinity or specificity characteristics are more likely to yield success than random mutagenesis. We present a library optimization method in which the choice of amino acids to encode at each peptide position can be guided by available experimental data or structure-based predictions. We discuss how to use analysis of predicted library performance to inform rounds of library design. Finally, we include protocols for more complex library design procedures that consider the chemical diversity of the amino acids at each peptide position and optimize a library score based on a user-specified input model.

  11. Specificity of Methylation Assays in Cancer Research: A Guideline for Designing Primers and Probes

    Directory of Open Access Journals (Sweden)

    Zeinab Barekati

    2010-01-01

    Full Text Available DNA methylation is an epigenetic regulation mechanism of genomic function, and aberrant methylation pattern has been found to be a common event in many diseases and human cancers. A large number of cancer studies have been focused on identification of methylation changes as biomarkers (i.e., breast cancer. However, still clinical use of them is very limited because of lack of specificity and sensitivity for diagnostic test. This highlights the critical need for specific primer and probe design to avoid false-positive detection of methylation profiling. The guideline and online web tools that are introduced in this paper might help to perform a successful experiment and to develop specific diagnosis biomarkers by designing right primer pair and probe prior to experimental step.

  12. Advanced energy design and operation technologies research: Recommendations for a US Department of Energy multiyear program plan

    Energy Technology Data Exchange (ETDEWEB)

    Brambley, M.R.; Crawley, D.B.; Hostetler, D.D.; Stratton, R.C.; Addision, M.S.; Deringer, J.J.; Hall, J.D.; Selkowitz, S.E.

    1988-12-01

    This document describes recommendations for a multiyear plan developed for the US Department of Energy (DOE) as part of the Advanced Energy Design and Operation Technologies (AEDOT) project. The plan is an outgrowth of earlier planning activities conducted for DOE as part of design process research under the Building System Integration Program (BSIP). The proposed research will produce intelligent computer-based design and operation technologies for commercial buildings. In this document, the concept is explained, the need for these new computer-based environments is discussed, the benefits are described, and a plan for developing the AEDOT technologies is presented for the 9-year period beginning FY 1989. 45 refs., 37 figs., 9 tabs.

  13. Understanding of Student Task Interpretation, Design Planning, and Cognitive Strategies during Engineering Design Activities in Grades 9-12. Final Report. Research in Engineering and Technology Education

    Science.gov (United States)

    Lawanto, Oenardi

    2011-01-01

    The objective of this study was to describe the task interpretation of students engaged in a design activity and determine the extent to which students translate their understanding of their design task to their planning and cognitive strategies. Twenty-nine students at one Colorado high school participated in this study. Students worked…

  14. Design, Specification, and Synthesis of Aircraft Electric Power Systems Control Logic

    Science.gov (United States)

    Xu, Huan

    Cyber-physical systems integrate computation, networking, and physical processes. Substantial research challenges exist in the design and verification of such large-scale, distributed sensing, actuation, and control systems. Rapidly improving technology and recent advances in control theory, networked systems, and computer science give us the opportunity to drastically improve our approach to integrated flow of information and cooperative behavior. Current systems rely on text-based specifications and manual design. Using new technology advances, we can create easier, more efficient, and cheaper ways of developing these control systems. This thesis will focus on design considerations for system topologies, ways to formally and automatically specify requirements, and methods to synthesize reactive control protocols, all within the context of an aircraft electric power system as a representative application area. This thesis consists of three complementary parts: synthesis, specification, and design. The first section focuses on the synthesis of central and distributed reactive controllers for an aircraft elec- tric power system. This approach incorporates methodologies from computer science and control. The resulting controllers are correct by construction with respect to system requirements, which are formulated using the specification language of linear temporal logic (LTL). The second section addresses how to formally specify requirements and introduces a domain-specific language for electric power systems. A software tool automatically converts high-level requirements into LTL and synthesizes a controller. The final sections focus on design space exploration. A design methodology is proposed that uses mixed-integer linear programming to obtain candidate topologies, which are then used to synthesize controllers. The discrete-time control logic is then verified in real-time by two methods: hardware and simulation. Finally, the problem of partial observability and

  15. Classifications for Coastal Wetlands Planning, Protection and Restoration Act site-specific projects: 2008 and 2009

    Science.gov (United States)

    Jones, William R.; Garber, Adrienne

    2012-01-01

    The Coastal Wetlands Planning, Protection and Restoration Act (CWPPRA) funds over 100 wetland restoration projects across Louisiana. Integral to the success of CWPPRA is its long-term monitoring program, which enables State and Federal agencies to determine the effectiveness of each restoration effort. One component of this monitoring program is the analysis of high-resolution, color-infrared aerial photography at the U.S. Geological Survey's National Wetlands Research Center in Lafayette, Louisiana. Color-infrared aerial photography (9- by 9-inch) is obtained before project construction and several times after construction. Each frame is scanned on a photogrametric scanner that produces a high-resolution image in Tagged Image File Format (TIFF). By using image-processing software, these TIFF files are then orthorectified and mosaicked to produce a seamless image of a project area and its associated reference area (a control site near the project that has common environmental features, such as marsh type, soil types, and water salinities.) The project and reference areas are then classified according to pixel value into two distinct classes, land and water. After initial land and water ratios have been established by using photography obtained before and after project construction, subsequent comparisons can be made over time to determine land-water change. Several challenges are associated with the land-water interpretation process. Primarily, land-water classifications are often complicated by the presence of floating aquatic vegetation that occurs throughout the freshwater systems of coastal Louisiana and that is sometimes difficult to differentiate from emergent marsh. Other challenges include tidal fluctuations and water movement from strong winds, which may result in flooding and inundation of emergent marsh during certain conditions. Compensating for these events is difficult but possible by using other sources of imagery to verify marsh conditions for other

  16. Processing of hand-related verbs specifically affects the planning and execution of arm reaching movements.

    Directory of Open Access Journals (Sweden)

    Giovanni Mirabella

    Full Text Available Even though a growing body of research has shown that the processing of action language affects the planning and execution of motor acts, several aspects of this interaction are still hotly debated. The directionality (i.e. does understanding action-related language induce a facilitation or an interference with the corresponding action?, the time course, and the nature of the interaction (i.e. under what conditions does the phenomenon occur? are largely unclear. To further explore this topic we exploited a go/no-go paradigm in which healthy participants were required to perform arm reaching movements toward a target when verbs expressing either hand or foot actions were shown, and to refrain from moving when abstract verbs were presented. We found that reaction times (RT and percentages of errors increased when the verb involved the same effector used to give the response. This interference occurred very early, when the interval between verb presentation and the delivery of the go signal was 50 ms, and could be elicited until this delay was about 600 ms. In addition, RTs were faster when subjects used the right arm than when they used the left arm, suggesting that action-verb understanding is left-lateralized. Furthermore, when the color of the printed verb and not its meaning was the cue for movement execution the differences between RTs and error percentages between verb categories disappeared, unequivocally indicating that the phenomenon occurs only when the semantic content of a verb has to be retrieved. These results are compatible with the theory of embodied language, which hypothesizes that comprehending verbal descriptions of actions relies on an internal simulation of the sensory-motor experience of the action, and provide a new and detailed view of the interplay between action language and motor acts.

  17. Patient-specific stopping power calibration for proton therapy planning based on single-detector proton radiography.

    Science.gov (United States)

    Doolan, P J; Testa, M; Sharp, G; Bentefour, E H; Royle, G; Lu, H-M

    2015-03-07

    A simple robust optimizer has been developed that can produce patient-specific calibration curves to convert x-ray computed tomography (CT) numbers to relative stopping powers (HU-RSPs) for proton therapy treatment planning. The difference between a digitally reconstructed radiograph water-equivalent path length (DRRWEPL) map through the x-ray CT dataset and a proton radiograph (set as the ground truth) is minimized by optimizing the HU-RSP calibration curve. The function of the optimizer is validated with synthetic datasets that contain no noise and its robustness is shown against CT noise. Application of the procedure is then demonstrated on a plastic and a real tissue phantom, with proton radiographs produced using a single detector. The mean errors using generic/optimized calibration curves between the DRRWEPL map and the proton radiograph were 1.8/0.4% for a plastic phantom and -2.1/ - 0.2% for a real tissue phantom. It was then demonstrated that these optimized calibration curves offer a better prediction of the water equivalent path length at a therapeutic depth. We believe that these promising results are suggestive that a single proton radiograph could be used to generate a patient-specific calibration curve as part of the current proton treatment planning workflow.

  18. OPEN COURSEWARE IN DESIGN AND PLANNING EDUCATION AND UTILIZATION OF DISTANCE EDUCATION OPPORTUNITY: Anadolu University Experience

    Directory of Open Access Journals (Sweden)

    Hicran Hanım HALAC

    2013-01-01

    Full Text Available Depending on the evolving technological possibilities, distance and online education applications have gradually gained more significance in the education system. Regarding the issues, such as advancements in the server services, disc capacity, cloud computing opportunities resulting from the increase in the number of the broadband internet users, web design applications; and increase in the number of mobile device and social media users and the time spent on the internet, traditional reading and working habits as well as the preferred information resources of man have considerably changed. In accordance with these changes, it has become an inevitable necessity to improve the higher education courses and learning materials. Any higher education system, which fails to keep up with these requirements, will inevitably have difficulties in providing the students with the necessary knowledge and skills within an appropriate workload frame. Within this context, one of the fields to benefit from distance and online education opportunities is undoubtedly “architecture and design education”. Although the use of computer technologies is inevasible and highly intensive in this field, the speed of conformance with the rapid technological changes and the adoption of the advancements is considerably slow compared to others. However, it is still among the fields where the technological opportunities are utilized at most. Thereby, distance and online education technologies present an essential potential to help students achieve the required planning and architectural knowledge and skills. In this respect, this article evaluates the distance and online education opportunities for design and planning education through the experience of Anadolu University.

  19. Three-dimensional seismic survey planning based on the newest data acquisition design technique; Saishin no data shutoku design ni motozuku sanjigen jishin tansa keikaku

    Energy Technology Data Exchange (ETDEWEB)

    Minehara, M.; Nakagami, K.; Tanaka, H. [Japan National Oil Corp., Tokyo (Japan). Technology Research Center

    1996-10-01

    Theory of parameter setting for data acquisition is arranged, mainly as to the seismic generating and receiving geometry. This paper also introduces an example of survey planning for three-dimensional land seismic exploration in progress. For the design of data acquisition, fundamental parameters are firstly determined on the basis of the characteristics of reflection records at a given district, and then, the layout of survey is determined. In this study, information through modeling based on the existing interpretation of geologic structures is also utilized, to reflect them for survey specifications. Land three-dimensional seismic survey was designed. Ground surface of the surveyed area consists of rice fields and hilly regions. The target was a nose-shaped structure in the depth about 2,500 m underground. A survey area of 4km{times}5km was set. Records in the shallow layers could not obtained when near offset was not ensured. Quality control of this distribution was important for grasping the shallow structure required. In this survey, the seismic generating point could be ensured more certainly than initially expected, which resulted in the sufficient security of near offset. 2 refs., 2 figs.

  20. Exploring governance learning: How policymakers draw on evidence, experience and intuition in designing participatory flood risk planning.

    Science.gov (United States)

    Newig, Jens; Kochskämper, Elisa; Challies, Edward; Jager, Nicolas W

    2016-01-01

    The importance of designing suitable participatory governance processes is generally acknowledged. However, less emphasis has been put on how decision-makers design such processes, and how they learn about doing so. While the policy learning literature has tended to focus on the substance of policy, little research is available on learning about the design of governance. Here, we explore different approaches to learning among German policymakers engaged in implementing the European Floods Directive. We draw on official planning documents and expert interviews with state-level policymakers to focus on learning about the procedural aspects of designing and conducting participatory flood risk management planning. Drawing on the policy learning and evidence-based governance literatures, we conceptualise six types of instrumental 'governance learning' according to sources of learning (endogenous and exogenous) and modes of learning (serial and parallel). We empirically apply this typology in the context of diverse participatory flood risk management planning processes currently unfolding across the German federal states. We find that during the first Floods Directive planning cycle, policymakers have tended to rely on prior experience in their own federal states with planning under the Water Framework Directive to inform the design and carrying out of participatory processes. In contrast, policymakers only sporadically look to experiences from other jurisdictions as a deliberate learning strategy. We argue that there is scope for more coordinated and systematic learning on designing effective governance, and that the latter might benefit from more openness to experimentation and learning on the part of policymakers.